title: Antibody responses to avian encephalomyelitis virus vaccines when administered by different routes.
abstract: Antibody responses to a commercial avian encephalomyelitis virus (AEV) vaccine administered by different routes were measured by an enzyme-linked immunosorbent assay (ELISA). Responses to single doses of vaccine administered by the ocular route to 10% of a flock were comparable with those obtained when all birds received a single dose in the drinking water. However, ocular vaccination of 5% of the flock resulted in significantly lower responses than those obtained when 10% were vaccinated. Maternal antibody was shown by the ELISA to persist in chickens from vaccinated flocks for up to 21 days after hatching. Day-old chickens with serum absorbances of < 0.3 at 492 nm, as determined by the ELISA, were shown to be susceptible to intracerebral challenge with the neurotropic Van Roekel strain of AEV.
authors.affiliation: Faculty of Medicine, University of Newcastle, Callaghan, New South Wales.
authors.forename: D R
authors.initials: DR
authors.lastname: Shafren
authors.forename: G A
authors.initials: GA
authors.lastname: Tannock
authors.forename: P J
authors.initials: PJ
authors.lastname: Groves
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D002645:Chickens; D004326:Drinking; D001350:Encephalomyelitis Virus, Avian / Q000276:immunology*; D004769:Enterovirus Infections / Q000517:prevention & control / Q000662:veterinary*; D007112:Immunity, Maternally-Acquired; D009883:Ophthalmic Solutions; D011201:Poultry Diseases / Q000517:prevention & control*; D013047:Specific Pathogen-Free Organisms; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D009883:Ophthalmic Solutions; D014765:Viral Vaccines