[Type 6/11 and 16/18 squamous epithelial cancers of the upper respiratory tract and digestive system. An in situ hybridization study].
61 squamous cell cancers (27 laryngeal, 12 hypopharyngeal, 14 tonsillary, 8 tongue) with different keratinization and grading and seven lymph node metastases of HPV 16/18 positive carcinomas were analysed for the presence of HPV-DNA by in situ hybridisation. 65.5% of them were found to be positive. Twelve laryngeal carcinomas (44%), five tonsillary tumours (35.7%), eight tumours of the hypopharynx (66.6%) and three tongue carcinomas (37.5%) were shown to contain HPV 16/18 DNA. The detection rates of HPV 6/11 were lower. 44 of the analysed tumours (72.1%) had a grading G2. 29 of these tumours (65.9%) were HPV positive. Only eight of the patients were no heavy smokers or alcoholic drinkers. One of the lymph node metastases was positive for HPV 16/18. The results indicate that HPV may be involved in the pathogenesis of squamous cell carcinomas of head and neck tumours.
Arndt
O
O
HNO-Abteilung, Marienkrankenhauses Hamburg.
Zeise
K
K
Bauer
I
I
Brock
J
J
D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D003043:Cocarcinogenesis; D015344:DNA Probes, HPV; D004279:DNA, Viral / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000473:pathology / Q000601:surgery; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000601:surgery; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D010039:Otorhinolaryngologic Neoplasms / Q000473:pathology* / Q000601:surgery; D027383:Papillomaviridae / Q000648:ultrastructure*; D014062:Tongue Neoplasms / Q000473:pathology / Q000601:surgery; D014067:Tonsillar Neoplasms / Q000473:pathology / Q000601:surgery; D014412:Tumor Virus Infections / Q000473:pathology* / Q000601:surgery
D015344:DNA Probes, HPV; D004279:DNA, Viral
Humane Papillomviren (HPV) vom Typ 6/11 und 16/18 in Plattenepithelkarzinomen des oberen Atmungs- und Verdauungstraktes. Eine In-situ-Hybridisierungsstudie.