Isoproterenol-induced Mg2+ uptake in liver.
Isoproterenol increased the Mg2+ content of hepatocytes after injection into rats or after addition to collagenase-dispersed hepatocytes. cAMP also the increased cellular Mg2+ content of isolated hepatocytes. This effect was prevented by staurosporine. Phorbol ester had no effect on the Mg2+ content of isolated hepatocytes, and after injection of isoproterenol into rats, protein kinase C of liver was not affected. It was concluded that isoproterenol induced long-term Mg2+ influx via the activation of protein kinase A which can be inhibited by staurosporine.
Günther
T
T
Institute of Molecular Biology and Biochemistry, Free University of Berlin, Germany.
Vormann
J
J
Höllriegl
V
V
D000470:Alkaloids / Q000494:pharmacology; D000818:Animals; D003994:Bucladesine / Q000378:metabolism; D002413:Cations, Divalent; D004789:Enzyme Activation; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism*; D008297:Male; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000378:metabolism; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D019311:Staurosporine; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D000470:Alkaloids; D002413:Cations, Divalent; D047428:Protein Kinase Inhibitors; D003994:Bucladesine; D011494:Protein Kinases; D011493:Protein Kinase C; D019311:Staurosporine; D008274:Magnesium; D007545:Isoproterenol; D013755:Tetradecanoylphorbol Acetate