title: [Synthesis and benzodiazepine receptor binding studies of pyridazino[3,4-b]indoles].
abstract: A series of methyl 9H-pyridazino[3,4-b]indole-3-carboxylates and related compounds were synthesized using a Diels-Alder reaction of methyl 3-(1H-indol-3-yl)-2-propenoates and dibenzyl azodicarboxylate. Several compounds were found to have high affinity for the benzodiazepine receptor. Their structure-activity relationships are discussed.
authors.affiliation: Sankyo Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Shimoji
authors.forename: K
authors.initials: K
authors.lastname: Tomita
authors.forename: T
authors.initials: T
authors.lastname: Karube
authors.forename: T
authors.initials: T
authors.lastname: Kamioka
mesh_terms: D000818:Animals; D007211:Indoles / Q000138:chemical synthesis* / Q000378:metabolism; D011724:Pyridazines / Q000138:chemical synthesis* / Q000378:metabolism; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D007211:Indoles; D011724:Pyridazines; D011963:Receptors, GABA-A