Application of a synthetic analogue of leu-enkephalin (Dalargin) in alcohol withdrawal.
The effects of 1 mg of a synthetic analogue of leu-enkephalin (Dalargin) injected intramuscular twice daily for 3 consecutive days were studied in 20 patients with alcohol withdrawal syndrome. The results suggest that the therapeutic effects of Dalargin in alcohol withdrawal syndrome are mainly connected with the changes in the dopamine-, serotonin-, GABA- and opioid-ergic neurotransmitters systems.
Aliyev
N A
NA
Mental Hospital, Baku Azerbaijan.
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D004298:Dopamine / Q000097:blood; D016308:Enkephalin, Leucine-2-Alanine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000431:Ethanol / Q000009:adverse effects*; D006801:Humans; D008297:Male; D012701:Serotonin / Q000097:blood; D013375:Substance Withdrawal Syndrome / Q000097:blood / Q000188:drug therapy*; D013565:Sympatholytics / Q000008:administration & dosage*; D005680:gamma-Aminobutyric Acid / Q000097:blood
D013565:Sympatholytics; D012701:Serotonin; D000431:Ethanol; D005680:gamma-Aminobutyric Acid; D016308:Enkephalin, Leucine-2-Alanine; D000324:Adrenocorticotropic Hormone; C040996:enkephalin-Leu, Ala(2)-Arg(6)-; D004298:Dopamine