Pharmacokinetics of endogenous substances.
The paper deals with the most relevant aspects related to the pharmacokinetics of the endogenous substances. Homeostatic equilibrium maintaining basal concentration of these substances, renal clearance and its role in preserving such equilibrium, the most appropriate pharmacokinetic analysis, the pharmacokinetic-pharmacodynamic relationships and the lack of specific regulatory aspects are the main items focused on.
Marzo
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A
Department of Drug Metabolism and Pharmacokinetics, Sigma-Tau S.p.A., Pomezia, Roma.
D000818:Animals; D006801:Humans; D007700:Kinetics; D011956:Receptors, Cell Surface / Q000378:metabolism*
D011956:Receptors, Cell Surface