Interactions of vitamin D with sodium zeolite A in rats from low and adequate vitamin D colonies.
Weanling rats (21 days old) from either a low vitamin D colony or an adequate vitamin D colony fed either a vitamin D adequate or a vitamin D deprived AIN-76A purified diet were used as a model to investigate interactions of vitamin D status with dietary sodium zeolite A (100 mg/kg body wt/day). Rats with adequate or replete vitamin D status had greater overall body weight gain, dry tibia weights and femur densities and ash weights than rats fed a vitamin D deprived diet. Addition of sodium zeolite A to the diets did not have an effect on plasma calcium, body weight gain or on femur density, ash and percent ash. Dietary sodium zeolite A increased total tibia fat in rats fed the vitamin D adequate diet and decreased total tibia fat in rats fed the vitamin D deprived diet. This effect of sodium zeolite A appeared to be beneficial to bone status in the groups fed adequate vitamin D, since these treatment groups had higher, although not significant, dry tibia weights with and without fat.
Keenan
M J
MJ
School of Human Ecology, Louisiana State University Agricultural Center, Baton Rouge 70803.
Hegsted
M
M
Wozniak
P J
PJ
Bott
J D
JD
Reisenauer
A
A
D000538:Aluminum Silicates / Q000494:pharmacology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D015519:Bone Density / Q000187:drug effects; D002118:Calcium / Q000097:blood; D004032:Diet; D004347:Drug Interactions; D005260:Female; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D014807:Vitamin D / Q000008:administration & dosage / Q000494:pharmacology*; D014808:Vitamin D Deficiency / Q000378:metabolism*; D017641:Zeolites
D000538:Aluminum Silicates; D017641:Zeolites; D014807:Vitamin D; D002118:Calcium