The modulatory effects of prostaglandins on both excitatory and inhibitory non-adrenergic non-cholinergic neurotransmission in guinea-pig airways.
Guinea-pig trachea and bronchi were used to investigate the effects of indomethacin and prostaglandin E2 (PGE2) on non-adrenergic non-cholinergic excitatory (e-NANC) and inhibitory (i-NANC) neurotransmission evoked by electrical field stimulation. Indomethacin potentiated e-NANC responses in bronchi with intact epithelium but had no effect on epithelium-denuded preparations. Inhibitory NANC responses were increased by indomethacin independent of the epithelium. Both i-NANC and e-NANC neurotransmission were suppressed by PGE2 in a dose-dependent manner. These results indicate that endogenous prostaglandins (e.g. PGE2) generated from the epithelium have an inhibitory effect on i-NANC and e-NANC nerve responses in airways. The epithelium is presumably not the only source for generation of prostaglandins that are involved in i-NANC neurotransmission.
Johansson-Rydberg
I G
IG
Department of Pharmacology, Faculty of Health Sciences, University of Linköping, Sweden.
Andersson
R G
RG
Grundström
N
N
D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D001980:Bronchi / Q000187:drug effects / Q000294:innervation; D015232:Dinoprostone / Q000494:pharmacology*; D004558:Electric Stimulation; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009130:Muscle, Smooth / Q000187:drug effects / Q000294:innervation; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology; D014132:Trachea / Q000187:drug effects / Q000294:innervation
D015232:Dinoprostone; D000109:Acetylcholine; D007213:Indomethacin