The effects of melanocortins and electrical fields on neuronal growth.
The effects of the neuropeptide molecules, adrenocorticotrophic hormone or alpha-melanocyte stimulating hormone, on various parameters of in vitro nerve growth, have been studied in the presence and absence of a small applied electric field. Striking effects on rates of nerve growth occurred. Selected concentrations of either substance alone, produced a three- to fourfold increase in nerve growth rate; other concentrations were inhibitory. The applied electric field alone increased rates of growth threefold. Further augmented rates of growth were seen when either neuropeptide was present simultaneously with an applied field. Under these latter conditions, galvanotropic (cathodal) orientation persisted, while nerve branching was suppressed. Given the clinical interest in melanocortin-stimulated nerve regeneration, perhaps a combined electrical and neuropeptide approach would be warranted.
McCaig
C D
CD
School of Biomedical Sciences, Division of Physiology, Marischal College, University of Aberdeen, Scotland.
Stewart
R
R
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D046508:Culture Techniques; D004558:Electric Stimulation; D004566:Electrodes; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology*; D009420:Nervous System / Q000166:cytology / Q000187:drug effects / Q000254:growth & development; D016501:Neurites / Q000502:physiology; D009474:Neurons / Q000166:cytology*; D014982:Xenopus laevis
D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones