Anterograde transport of HSV-1 and HSV-2 in the visual system.
The anterograde spread of herpesvirus in the visual system subsequent to retinitis has been observed clinically. We compared the ability of two well-studied Herpes simplex virus (HSV) strains to be transported in the anterograde direction in the hamster visual system: strain McIntyre, representing HSV-1, and strain 186, representing HSV-2. Intravitreal injection of HSV-2 labeled more retinorecipient neurons than did HSV-1, suggesting important type differences in the ability of HSV to infect retinorecipient neurons after intravitreal injection. The most likely explanation for our results is that HSV-2 is more efficiently adsorbed than HSV-1 in the retinal ganglion cells. Our results also suggest that HSV may be useful as an anterograde transneuronal tracer for neuroanatomical studies of the visual system.
Norgren
R B
RB
Department of Anatomy and Cell Biology, University of Cincinnati College of Medicine, OH 45267-0521.
McLean
J H
JH
Bubel
H C
HC
Wander
A
A
Bernstein
D I
DI
Lehman
M N
MN
D000818:Animals; D001921:Brain / Q000166:cytology / Q000382:microbiology; D002772:Cholera Toxin; D006224:Cricetinae; D006735:Horseradish Peroxidase; D007150:Immunohistochemistry; D016849:Keratitis, Herpetic / Q000382:microbiology / Q000635:transmission*; D008297:Male; D008647:Mesocricetus; D009457:Neuroglia / Q000382:microbiology; D018139:Simplexvirus; D014795:Visual Pathways / Q000382:microbiology*
D002772:Cholera Toxin; D006735:Horseradish Peroxidase