[Effects of Ligustricum Wallichii on acute nephrotoxicity induced by cyclosporine A in rats].
We investigated the influence of cyclosporine A (CsA) on renal function, renin-angiotensin system (RAS) and platelet aggregation in addition to the effect of Ligusticum Wallichii (LW) on CsA actions in SD rats. Infusion of CsA (50 mg/kg, iv) resulted in a significant fall in glomerular filtration rate (GFR) and renal plasma flow (RPF) and a significant increase of plasma renin activity (PRA), angiotensin II (A II) level and percentage platelet aggregation. At the same time, treatment with 20% LW (8 ml/kg, iv) before CsA infusion significantly prevented the decline of GFR and RPF as well as the enhancement of platelet aggregation, but had no influence on CsA-mediated RAS activation. These results suggested that LW may be beneficial to the acute nephrotoxicity induced by CsA.
Liu
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Department of Nephrology, Chang Zheng Hospital, Second Military Medical University, Shanghai.
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D016572:Cyclosporine; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012084:Renin-Angiotensin System / Q000187:drug effects
D004365:Drugs, Chinese Herbal; D010975:Platelet Aggregation Inhibitors; D016572:Cyclosporine