title: Intracellular synthesis of varicella-zoster virus.
abstract: Varicella-zoster virus, a reclusive alpha-herpesvirus, can be isolated and propagated in a limited number of human cell lines. Under in vitro conditions, the virus is strongly cell-associated and, therefore, difficult to recover in a truly cell-free state. The general replication cycle includes the three phases called immediate early, early, and late. An example of an early viral protein is a putative protein kinase called open reading frame (ORF) 47. An example of a late protein is the preponderant viral glycoprotein (ORF 68) designated VZV gpI.
authors.affiliation: Department of Pediatrics, University of Iowa, College of Medicine, Iowa City.
authors.forename: C
authors.initials: C
authors.lastname: Grose
authors.forename: T I
authors.initials: TI
authors.lastname: Ng
mesh_terms: D000595:Amino Acid Sequence; D002460:Cell Line; D015870:Gene Expression; D005814:Genes, Viral; D014645:Herpesvirus 3, Human / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D008969:Molecular Sequence Data; D014764:Viral Proteins / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics; D014779:Virus Replication
chemical_list: D014764:Viral Proteins