Hydroxylated kininogens and kinins.
Hydroxyprolyl-3-bradykinin was identified in the digest of purified human high molecular weight (H) kininogen with plasma kallikrein. Hydroxyproline was not detected in the heavy and light chains portions of H kininogen, although they include three possible sites for hydroxylation of proline by proline hydroxylase. The content of hydroxyprolyl-3-bradykinin in H kininogen from individual plasmas varied from 14% to 64% of total kinin. The present results and our previous results indicate that only kinin moity in H kininogen from human and monkey plasmas has been partially hydroxylated post-translationally by proline-4-hydroxylase.
Kato
H
H
National Cardiovascular Center Research Institute, Osaka, Japan.
Enjyoji
K
K
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001665:Binding Sites; D001920:Bradykinin / Q000031:analogs & derivatives / Q000378:metabolism; D006801:Humans; D006900:Hydroxylation; D006909:Hydroxyproline / Q000378:metabolism; D066298:In Vitro Techniques; D007610:Kallikreins / Q000378:metabolism; D007704:Kininogens / Q000737:chemistry / Q000378:metabolism*; D007705:Kinins / Q000378:metabolism*; D011393:Procollagen-Proline Dioxygenase / Q000378:metabolism; D011499:Protein Processing, Post-Translational
D000596:Amino Acids; D007704:Kininogens; D007705:Kinins; C021698:bradykinin, hydroxy-Pro(3)-; D011393:Procollagen-Proline Dioxygenase; D007610:Kallikreins; D006909:Hydroxyproline; D001920:Bradykinin