title: Angiotensin-converting enzyme inhibitors, left ventricular dysfunction, and early heart failure.
abstract: A study was undertaken to examine the effects of the angiotensin-converting enzyme inhibitor lisinopril on exercise performance in 18 patients with major impairment of left ventricular systolic function. The study was a randomized, double-blind, crossover design, and patients received treatment with either once-daily lisinopril (2.5-10 mg) or placebo for a period of 6 weeks. A total of 15 patients completed the study. Compared with placebo, lisinopril had no significant effect on supine or standing blood pressure or heart rate. Although lisinopril had no effect on exercise duration during a low-intensity exercise protocol, in patients undergoing a high-intensity exercise protocol, there was a trend toward improved exercise time and peak oxygen consumption improved significantly. In addition, treatment with lisinopril resulted in an increase in renal blood flow and a reduction in glomerular filtration rate. Moreover, administration of once-daily lisinopril 10 mg resulted in a decrease in plasma concentrations of angiotensin II, aldosterone, and atrial natriuretic peptide, and an increase in plasma concentrations of active renin.
authors.affiliation: Department of Medicine (Cardiology), Hammersmith Hospital, London, United Kingdom.
authors.forename: J G
authors.initials: JG
authors.lastname: Cleland
authors.forename: D
authors.initials: D
authors.lastname: Shah
authors.forename: S
authors.initials: S
authors.lastname: Krikler
authors.forename: G
authors.initials: G
authors.lastname: Frost
authors.forename: C M
authors.initials: CM
authors.lastname: Oakley
mesh_terms: D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II / Q000097:blood; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D009320:Atrial Natriuretic Factor / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D002303:Cardiac Output, Low / Q000097:blood / Q000188:drug therapy*; D004151:Dipeptides / Q000627:therapeutic use*; D004311:Double-Blind Method; D005080:Exercise Test; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D017706:Lisinopril; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects; D010919:Placebos; D012079:Renal Circulation / Q000187:drug effects; D013318:Stroke Volume / Q000187:drug effects; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D004151:Dipeptides; D010919:Placebos; D000804:Angiotensin II; D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D017706:Lisinopril