[The prostaglandin I2 and thromboxane A2 content of the blood of dogs in the dynamic development of hemorrhagic shock].
The content of prostaglandin I2 (PGI2) and thromboxane (Tx) A2 in the venous blood was studied in 5 dogs in the time course of hemorrhagic shock simulated by a single jet blood-letting from the femoral artery. PGI2 and TxA2 concentrations were estimated by the levels of their stable metabolites in RIA. It was found that acute hemorrhage stimulated the synthesis of prostanoids studied up to the animals' death. However, with the shock progressing, a shift took place in the ratio PGI2/TxA2 from 1:3.8 to 1:5.2, due to a higher rise of TxA2. Possible causes of PGI2 synthesis decrease and TxA2 production increase in hemorrhagic shock were considered. Basing on the data obtained a conclusion has been made on the necessity of exogenous PGI2 (prostacyclin) inclusion into the combined therapy of hemorrhagic shock.
Oborin
A N
AN
Chuklin
S N
SN
Kobrin
T M
TM
D000818:Animals; D001794:Blood Pressure; D004195:Disease Models, Animal; D004285:Dogs; D011464:Epoprostenol / Q000097:blood*; D012771:Shock, Hemorrhagic / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D013928:Thromboxane A2 / Q000097:blood*; D014680:Veins
D013928:Thromboxane A2; D011464:Epoprostenol
Soderzhanie prostaglandina I2 i tromboksana A2 v krovi sobak v dinamike razvitiia gemorragicheskogo shoka.