D-penicillamine therapy associated with rapidly progressive glomerulonephritis.
A 55-year-old woman with advanced rheumatoid arthritis developed rapidly progressive glomerulonephritis with epithelial crescents and pulmonary hemorrhage following treatment with D-penicillamine. D-penicillamine was then withdrawn and a pulse therapy with methylprednisolone halted the progression of kidney and lung damage. We review the other cases previously reported and discuss pathogenesis and treatment of this rare condition.
Macarrón
P
P
Rheumatology Unit, Hospital Virgen de la Salud, Toledo, Spain.
García Díaz
J E
JE
Azofra
J A
JA
Martín de Francisco
J
J
Gonzalez
E
E
Fernandez
G
G
Sampedro
J
J
D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D005260:Female; D005921:Glomerulonephritis / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D006469:Hemoptysis / Q000139:chemically induced; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D010396:Penicillamine / Q000009:adverse effects*
D010396:Penicillamine; D008775:Methylprednisolone