title: [Successful preparation of mitoxantrone emulsion containing non-ionic contrast medium].
abstract: Mitoxantrone, a new anti-cancer agent, was successfully prepared for Lipiodol emulsion. The mixture of Mitoxantrone and non-ionic contrast medium, Omnipaque 300, was combined with Lipiodol at the ratio of 1:2. When the ratio of Mitoxantrone and Lipiodol was 1:4, microscopic study revealed stabilized water in oil emulsion, which could release the anti-cancer agent slowly. We applied it for a case of hepatocellular carcinoma with good result. Intra-arterial infusion of this emulsion might be considered effective for treatment of hepatocellular carcinoma.
authors.affiliation: Second Dept. of Surgery, Tokyo Medical and Dental University, School of Medicine.
authors.forename: W
authors.initials: W
authors.lastname: Ichikawa
authors.forename: Z
authors.initials: Z
authors.lastname: Nihei
authors.forename: S
authors.initials: S
authors.lastname: Sawai
authors.forename: T
authors.initials: T
authors.lastname: Yamashita
authors.forename: H
authors.initials: H
authors.lastname: Uetake
authors.forename: Y
authors.initials: Y
authors.lastname: Kawachi
authors.forename: R
authors.initials: R
authors.lastname: Hirayama
authors.forename: Y
authors.initials: Y
authors.lastname: Mishima
authors.forename: H
authors.initials: H
authors.lastname: Tamaru
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000473:pathology; D003692:Delayed-Action Preparations; D004359:Drug Therapy, Combination; D004655:Emulsions; D006801:Humans; D007459:Iodized Oil / Q000008:administration & dosage*; D007472:Iohexol / Q000008:administration & dosage*; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008942:Mitoxantrone / Q000008:administration & dosage*
chemical_list: D003692:Delayed-Action Preparations; D004655:Emulsions; D007472:Iohexol; D007459:Iodized Oil; D008942:Mitoxantrone