Forestomach papillomas in flaky skin and steel-Dickie mutant mice.
Gastric papillomas were diagnosed in flaky skin (fsn/fsn) and steel-Dickie (Sl/Sld) mutant mice but not littermate controls. Both mutants suffer from severe anemia of differing causes. Immunohistochemical screening and Southern blot analyses failed to detect any evidence of a papillomavirus in the gastric lesions. Phenotypic expression of the fsn and Sld mutant genes may play an essential role in the spontaneous development of forestomach papillomas in these mouse mutants.
Sundberg
J P
JP
Jackson Laboratory, Bar Harbor, ME 04609.
Kenty
G A
GA
Beamer
W G
WG
Adkison
D L
DL
D000740:Anemia / Q000235:genetics / Q000662:veterinary; D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D015139:Blotting, Southern; D015344:DNA Probes, HPV; D004279:DNA, Viral / Q000032:analysis; D006720:Homozygote; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D010212:Papilloma / Q000235:genetics / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D027383:Papillomaviridae / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D010641:Phenotype; D012376:Rodent Diseases / Q000235:genetics / Q000382:microbiology* / Q000473:pathology; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000235:genetics / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*
D000956:Antigens, Viral; D015344:DNA Probes, HPV; D004279:DNA, Viral