Brain tryptophan uptake and sodium-potassium ATPase activity in long-term streptozotocin diabetic rats.
Serum, liver and brain tryptophan concentrations and brain Na+K(+)-ATPase activity were studied in streptozotocin diabetic rats after an acute tryptophan load. Results show that tryptophan administration in the experimental diabetic group produces a generalized fall in tryptophan uptake in all the brain regions studied, though it does not increase serum and hepatic tryptophan concentrations. These parameters are normalized in insulin-treated diabetic rats. With regard to Na+K(+)-ATPase, diabetic animals showed a diminished and unchanged activity; whereas, the other two experimental groups showed a gradual decrease and a negative correlation with brain tryptophan uptake.
Atienza
G
G
Department of Physiology, Faculty of Biology, University of Santiago de Compostela, La Coruña, Spain.
Andres
M D
MD
Rebolledo
E
E
Aldegunde
M
M
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000201:enzymology / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects / Q000378:metabolism*; D013997:Time Factors; D014364:Tryptophan / Q000097:blood / Q000378:metabolism*
D007328:Insulin; D014364:Tryptophan; D000254:Sodium-Potassium-Exchanging ATPase