Multiple genes for Xenopus activin receptor expressed during early embryogenesis.
Four distinct cDNAs for activin receptor designated as XSTK2, 3, 8 and 9 have been cloned from a Xenopus laevis cDNA library. The protein structures deduced from the cDNAs have shown that they all have a putative extracellular ligand-binding domain, a single transmembrane domain and cytoplasmic Ser/Thr kinase domain, except that XSTK2 is extremely similar to the XSTK3 gene but lacks a carboxyl-terminal part of the kinase motif. Northern blot analysis showed that all transcripts are maternally inherited. The levels of transcript for XSTK2, 3 and 8 appeared to fluctuate during early development while those for XSTK9 maintain constant.
Nishimatsu
S
S
Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan.
Oda
S
S
Murakami
K
K
Ueno
N
N
D029404:Activin Receptors; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D015139:Blotting, Southern; D004247:DNA / Q000235:genetics; D004625:Embryo, Nonmammalian / Q000378:metabolism*; D008969:Molecular Sequence Data; D011494:Protein Kinases / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D011956:Receptors, Cell Surface / Q000235:genetics*; D015183:Restriction Mapping; D016415:Sequence Alignment; D014158:Transcription, Genetic; D014981:Xenopus / Q000196:embryology / Q000378:metabolism*
D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D004247:DNA; D011494:Protein Kinases; D029404:Activin Receptors