Mitotic checkpoints.
Entry into mitosis is triggered by activation of maturation promoting factor and a complex of p34cdc2 kinase and cyclin B. Activation induces nuclear lamina breakdown, chromosome condensation and mitotic spindle assembly. Exit from mitosis is initiated by the degradation of cyclin B and the subsequent inactivation of maturation-promoting factor. A more thorough understanding of the checkpoints for initiation of and exit from mitosis has evolved during the past few years.
Nishimoto
T
T
Kyushu University, Fukuoka, Japan.
Uzawa
S
S
Schlegel
R
R
D000818:Animals; D016213:Cyclins / Q000502:physiology; D020558:GTP Phosphohydrolases / Q000502:physiology; D006801:Humans; D008938:Mitosis / Q000235:genetics / Q000502:physiology*; D008954:Models, Biological; D010744:Phosphoric Monoester Hydrolases / Q000502:physiology; D011494:Protein Kinases / Q000502:physiology
D016213:Cyclins; D011494:Protein Kinases; D010744:Phosphoric Monoester Hydrolases; D020558:GTP Phosphohydrolases