In vivo interactions of pentylenetetrazole with benzodiazepine receptors: lack of direct correlation between benzodiazepine receptor occupancy and convulsant potency of this drug.
Chavoix
C
C
Département de Biologie, Service Hospitalier Frédéric Joliot, C.E.A., Orsay, France.
Brouillet
E
E
Hantraye
P
P
de la Sayette
V
V
Kunimoto
M
M
Varastet
M
M
Guibert
B
B
Dodd
R H
RH
Fournier
D
D
Naquet
R
R
D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects; D005442:Flumazenil / Q000493:pharmacokinetics; D008297:Male; D010215:Papio; D010433:Pentylenetetrazole / Q000494:pharmacology*; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000502:physiology; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology; D013226:Status Epilepticus / Q000139:chemically induced / Q000503:physiopathology; D014055:Tomography, Emission-Computed
D011963:Receptors, GABA-A; D005442:Flumazenil; D010433:Pentylenetetrazole