[Na/H antiporter].
Na/H antiporter located in the plasma membrane is mandatory to maintain cell pH. Two isoforms with different sensitivities to amiloride have been identified. They seem to be products from different mRNAs. The amiloride-sensitive form exists in the non-epithelial cells and the basal membrane of the epithelial cells. The amiloride-resistant form is confined in the apical membrane of the epithelial cells and is important for the vectorial transport of HCO3-. The amiloride-sensitive form has been cloned and sequenced. It is a glycoprotein composed of 815 amino acids. Functional analysis of Na/H antiporter by expressing mutant Na/H antiporter cDNA is in progress.
Takaichi
K
K
Fourth Department of Internal Medicine, University of Tokyo.
D000818:Animals; D002352:Carrier Proteins / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000378:metabolism; D017923:Sodium-Hydrogen Exchangers
D002352:Carrier Proteins; D017923:Sodium-Hydrogen Exchangers