Sensitivity of in vivo MRS of the N-delta proton in proximal histidine of deoxymyoglobin.
The sensitivity of in vivo MRS of the N-delta proton of the proximal histidine of deoxymyoglobin in human skeletal muscles is discussed. Longitudinal relaxation time T1 of this deoxymyoglobin signal was measured in cuffed human forearms at 1.5 T and found to be 9.9 ms. Deoxymyoglobin spectra can be obtained from a forearm in seconds. The detection sensitivity of deoxymyoglobin in fully ischemic skeletal muscles and that of 31P MRS of PCr in normal resting muscles are compared.
Wang
Z
Z
Department of Radiology, University of Pennsylvania, Philadelphia 19104.
Wang
D J
DJ
Noyszewski
E A
EA
Bogdan
A R
AR
Haselgrove
J C
JC
Reddy
R
R
Zimmerman
R A
RA
Leigh
J S
JS
D000328:Adult; D000818:Animals; D002417:Cattle; D005260:Female; D005542:Forearm / Q000098:blood supply; D006639:Histidine / Q000378:metabolism*; D006801:Humans; D007511:Ischemia / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D009132:Muscles / Q000098:blood supply / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D009211:Myoglobin / Q000031:analogs & derivatives* / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D010758:Phosphorus; D011522:Protons
D009211:Myoglobin; D011522:Protons; C055547:deoxymyoglobin; D010725:Phosphocreatine; D010758:Phosphorus; D006639:Histidine