Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene.
A new human gene encoding a putative receptor-type tyrosine kinase (RTK) was isolated by screening a placenta cDNA library with a mouse Flt3 probe. The deduced amino acid sequence of the intracellular region of the molecule showed that it was strongly related to the FLT1 and KDR/FLK1 gene products and to a lesser degree to members of the class III RTKs: FMS/CSF1R, PDGFRA/B, KIT, and FLT3. The gene was named FLT4. Cosmid clones of the mouse Flt4 gene were isolated. The human gene was localized to bands q34-q35 of chromosome 5, i.e., slightly telomeric to the CSF1R/PDGRFB tandem of genes, and the mouse homolog to chromosome 11, region A5-B1.
Galland
F
F
Laboratory of Molecular Oncology, U. 119 INSERM, Marseille, France.
Karamysheva
A
A
Mattei
M G
MG
Rosnet
O
O
Marchetto
S
S
Birnbaum
D
D
D000595:Amino Acid Sequence; D000818:Animals; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5; D005796:Genes; D006801:Humans; D051379:Mice / Q000235:genetics*; D008969:Molecular Sequence Data; D005810:Multigene Family; D009693:Nucleic Acid Hybridization; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D011956:Receptors, Cell Surface / Q000235:genetics*; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D040321:Vascular Endothelial Growth Factor Receptor-3
D011956:Receptors, Cell Surface; D011505:Protein-Tyrosine Kinases; D040321:Vascular Endothelial Growth Factor Receptor-3