Effect of dibutyryl cyclic AMP-treatment on prostaglandin F2 alpha-stimulated phosphoinositide hydrolysis in cultured rat astrocytes.
Dibutyryl cyclic AMP (dBcAMP)-treatment of cultured rat astrocytes induced changes in astrocyte morphology followed by the potentiation of prostaglandin F2 alpha (PGF2 alpha)-stimulated phosphoinositide (PI) hydrolysis. The potentiation was observed in astrocytes of the cerebral cortex, cerebellum, and hippocampus. The dBcAMP-treatment induced agonists-specific changes in PI hydrolysis; e.g., the potentiation of norepinephrine-effect and the reduction of the carbachol-effect. Coincubations of carbachol or norepinephrine with PGF2 alpha produced additive responses.
Kitanaka
J
J
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Baba
A
A
D000818:Animals; D001253:Astrocytes / Q000187:drug effects* / Q000378:metabolism; D003994:Bucladesine / Q000494:pharmacology*; D002478:Cells, Cultured; D015237:Dinoprost / Q000494:pharmacology*; D006868:Hydrolysis; D010716:Phosphatidylinositols / Q000378:metabolism*; D051381:Rats
D010716:Phosphatidylinositols; D003994:Bucladesine; D015237:Dinoprost