Fructose 2,6-bisphosphate in developing rat brain.
Fructose 2,6-bisphosphate (Fru-2,6-P2) levels and 6-phosphofructo-1-kinase and 6-phosphofructo-2-kinase activities have been studied in rat brain during development from embryonal to adult state. Fru-2,6-P2 increases slightly from day 16 of gestation, reaching a maximum 24 h after birth, remaining quite constant during postnatal development. In contrast with 6-phosphofructo-1-kinase, which increases progressively after the first week of age, 6-phosphofructo-2-kinase remains unaltered throughout the period studied. The role of Fru-2,6-P2 in controlling cerebral glycolysis is discussed.
Ambrosio
S
S
Departament de Ciències Fisiològiques, Universitat de Barcelona, Spain.
Ventura
F
F
Bartrons
R
R
D000818:Animals; D001921:Brain / Q000196:embryology / Q000201:enzymology / Q000254:growth & development*; D001923:Brain Chemistry / Q000502:physiology*; D005260:Female; D005635:Fructosediphosphates / Q000096:biosynthesis*; D010732:Phosphofructokinase-1 / Q000378:metabolism; D025481:Phosphofructokinase-2; D010770:Phosphotransferases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D005635:Fructosediphosphates; C027652:fructose 2,6-diphosphate; D010770:Phosphotransferases; D025481:Phosphofructokinase-2; D010732:Phosphofructokinase-1