title: Herpesvirus infection of the respiratory tract in patients with alcoholic hepatitis.
abstract: Respiratory herpesvirus infections have rarely been described in alcoholics. We report four cases of severe respiratory herpesvirus infections in patients with alcoholic liver disease. Two were related to Herpes Simplex Virus and two to Cytomegalovirus. Both chronic alcoholism and severe liver disease induce immunosuppression, which might account for these unusual herpesvirus infections of the respiratory tract. These cases suggest that infections with herpesviruses should be considered in patients with alcoholic liver disease and pulmonary or tracheobronchial disease unresponsive to standard antibiotic therapy. Bronchoscopy, viral culture, and serological tests appear warranted, particularly given the existence of specific therapy.
authors.affiliation: Service d'Hépatologie, Hôpital Beaujon, Clichy, France.
authors.forename: S
authors.initials: S
authors.lastname: Pol
authors.forename: F
authors.initials: F
authors.lastname: Durand
authors.forename: J
authors.initials: J
authors.lastname: Bernuau
authors.forename: J F
authors.initials: JF
authors.lastname: Colin
authors.forename: F
authors.initials: F
authors.lastname: Dubois
authors.forename: M
authors.initials: M
authors.lastname: Hautekeete
authors.forename: C
authors.initials: C
authors.lastname: Rouzioux
authors.forename: C
authors.initials: C
authors.lastname: Degott
authors.forename: B
authors.initials: B
authors.lastname: Rueff
authors.forename: J P
authors.initials: JP
authors.lastname: Benhamou
mesh_terms: D000328:Adult; D003586:Cytomegalovirus Infections / Q000175:diagnosis*; D005260:Female; D006519:Hepatitis, Alcoholic / Q000175:diagnosis*; D006561:Herpes Simplex / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000175:diagnosis*; D012131:Respiratory Insufficiency / Q000175:diagnosis; D012141:Respiratory Tract Infections / Q000175:diagnosis*; D014766:Viremia / Q000175:diagnosis