title: Influence of free radical scavengers on myeloperoxidase activity and lipid peroxidation in acute skin grafts.
abstract: Activated neutrophil granulocytes are an important source of oxygen free radicals in acute skin grafts. Lipid peroxidation and immigration of PMNs, indicating inflammatory mechanisms, affect each other to a variable extent. The effect of the scavengers allopurinol and alpha-D-tocopherol on both lipid peroxidation and neutrophilic infiltration was investigated. A possible mechanism for the superior effect of allopurinol compared to vitamin E was discussed.
authors.affiliation: Department of Dermatology, University of Wuerzburg, Germany.
authors.forename: R K
authors.initials: RK
authors.lastname: Goldstein
authors.forename: A
authors.initials: A
authors.lastname: Augustin
authors.forename: J
authors.initials: J
authors.lastname: Milz
authors.forename: G
authors.initials: G
authors.lastname: Burg
authors.forename: J
authors.initials: J
authors.lastname: Lutz
mesh_terms: D000493:Allopurinol / Q000494:pharmacology; D000818:Animals; D016166:Free Radical Scavengers; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D009336:Necrosis; D009504:Neutrophils / Q000201:enzymology / Q000473:pathology; D009195:Peroxidase / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D016038:Skin Transplantation / Q000009:adverse effects / Q000473:pathology / Q000502:physiology*; D014810:Vitamin E / Q000494:pharmacology
chemical_list: D016166:Free Radical Scavengers; D014810:Vitamin E; D000493:Allopurinol; D009195:Peroxidase