[The structural organization and neurochemical mechanisms of the participation of the nucleus accumbens in the interaction of the limbic and motor systems and in the regulation of motor behavior].
The review of own and literature data devoted to structural and neurochemical organization of the nucleus accumbens (Acc) as well as spatial organization of their projection fibers in comparison with nucleus caudatus (neostriatum) has been presented. The facts concerned with correlations revealed between both the cell clusters and histochemical compartments as well as the compartmental organization of afferent and efferent striatal connections were analyzed. The presented data propose the existence of sensorimotor and limbic parts of the dorsal and ventral striatum, which are involved in the parallelly functioning systems. The common and different signs of these two systems and its role in the regulation of the movement behaviour has been proposed. A lot of attention also was payed to the Acc and the neostriatum interaction. The many pathways by which Acc can influence neostriatum functions and therefore the motor activity controlled by the neostriatum are discussed. It was shown that the Acc can influence on the striatal synaptic DA release. The sign of this influence depended upon DA/glutamic acid interactions in the Acc. It was stressed that the influence of Acc on striatal DA-ergic system is very likely mediated via kainate/quisqualate (but not NMDA) inputs of the neostriatum. The balance of DA-ergic mechanisms of neostriatum and Acc as important basis of animals adequate behaviour in conditioning situation was proposed. The disbalance of these mechanisms could leads to pathology.
Shapovalova
K B
KB
Gorbachevskaia
A I
AI
Saul'skaia
N B
NB
D000344:Afferent Pathways / Q000033:anatomy & histology / Q000502:physiology; D000818:Animals; D004525:Efferent Pathways / Q000033:anatomy & histology / Q000502:physiology; D008032:Limbic System / Q000502:physiology*; D008124:Locomotion / Q000502:physiology; D009043:Motor Activity / Q000502:physiology*; D009044:Motor Cortex / Q000502:physiology*; D009490:Neurosecretory Systems / Q000033:anatomy & histology* / Q000502:physiology; D009714:Nucleus Accumbens / Q000033:anatomy & histology* / Q000502:physiology
Strukturnaia organizatsiia i neĭrokhimicheskie mekhanizmy uchastiia prilezhashchego iadra vo vzaimodeĭstvii limbicheskoĭ i motornoĭ sistem i v reguliatsii dvigatel'nogo povedeniia.