title: Preparation of the renal function and imaging agent 99mTc-MAG3 starting from S-unprotected mercaptoacetyltriglycine.
abstract: A new approach that obviates inconvenient heating of the labelling solution when preparing the renal function and imaging agent 99mTc-MAG3 is described. The labelling procedure involves reduction of 99mTc-generator eluate with stannous chloride in alkaline solution in the presence of S-unprotected mercaptoacetyltriglycine (MAG3) and the co-ligand sodium tartrate, followed by neutralization with a phosphate buffer solution. After optimization of the kit preparation the radiochemical purity of the radiopharmaceutical amounts to greater than 98%. During the labelling process intermediate Tc-species occur.
authors.affiliation: Central Institute of Nuclear Research, Rossendorf, Dresden, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Noll
authors.forename: B
authors.initials: B
authors.lastname: Johannsen
authors.forename: K
authors.initials: K
authors.lastname: May
authors.forename: H
authors.initials: H
authors.lastname: Spies
mesh_terms: D009842:Oligopeptides / Q000138:chemical synthesis*; D015609:Organotechnetium Compounds / Q000138:chemical synthesis*; D011933:Reagent Kits, Diagnostic; D017263:Technetium Tc 99m Mertiatide
chemical_list: D009842:Oligopeptides; D015609:Organotechnetium Compounds; D011933:Reagent Kits, Diagnostic; D017263:Technetium Tc 99m Mertiatide