title: [The significance of the mu- and delta-opiate receptors in realizing enkephalin action on the course of hypoxic hypoxia].
abstract: New enkephalins analogues have been synthesized. They are characterized by linear, cyclic and branched peptide chain. A relationship has been established between antihypoxic activity of opioid peptides an their interaction with opiate receptors. Compounds efficiently interacting with mu-receptors irrespective of delta-receptors affinity, promote longer survival of mice in hypoxia. The antihypoxic effect of opioids is proportional to their specificity to mu-receptors.
authors.forename: G K
authors.initials: GK
authors.lastname: Zoloev
authors.forename: E S
authors.initials: ES
authors.lastname: Argintaev
authors.forename: I V
authors.initials: IV
authors.lastname: Bobrova
authors.forename: M G
authors.initials: MG
authors.lastname: Shil'nikov
authors.forename: V S
authors.initials: VS
authors.lastname: Pavlenko
authors.forename: N A
authors.initials: NA
authors.lastname: Abisova
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical; D004745:Enkephalins / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D006168:Guinea Pigs; D000860:Hypoxia / Q000188:drug therapy* / Q000401:mortality; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011957:Receptors, Opioid / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D004745:Enkephalins; D011957:Receptors, Opioid
vernacular_title: Znachenie miu- i del'ta-opiatnykh retseptorov v realizatsii deĭstviia énkefalinov na techenie gipoksicheskoĭ gipoksii.