Effect of antihypertensive therapy on left ventricular hypertrophy and on its pathophysiologic sequelae.
Recent evidence has shown that a decrease in left ventricular hypertrophy (LVH) by antihypertensive agents suppresses ventricular ectopy, improves ventricular filling, and maintains or even enhances LV function. However, not all antihypertensive drugs reverse LVH or reduce ectopy in spite of their ability to lower blood pressure. Preliminary data suggest that the reversal of LVH is linked to a decrease in cardiovascular morbidity and mortality.
Messerli
F H
FH
Department of Internal Medicine, Ochsner Clinic, New Orleans, LA.
D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology*; D009200:Myocardial Contraction / Q000187:drug effects; D017202:Myocardial Ischemia / Q000188:drug therapy / Q000209:etiology*
D000959:Antihypertensive Agents