The Na+/H+ antiporter in oncology in the light of the spontaneous regression of cancer and cell metabolism.
Multiple metabolic and biochemical interrelationships, as well as the most recent views on mechanisms of malignant cell growth, proliferation, and oncogen activity mediated by the Na+/H+ antiporter, can be integrated from the unitarian point of view of the dynamics of the hydrogen ion to parallel pH-related mechanisms involved in the Spontaneous Regression (SR) of some malignant tumors. Also, pH-related growth inhibitors of the amiloride series are considered as possible agents to be used in the adjuvant and co-adjuvant treatment of some human tumors as well as in the control of the metastatic process and in overcoming cancer multidrug resistance (MDR).
Harguindey
S
S
Clinica La Esperanza, Vitoria, Spain.
Cragoe
E J
EJ
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008954:Models, Biological; D009365:Neoplasm Regression, Spontaneous / Q000503:physiopathology*; D009369:Neoplasms / Q000150:complications / Q000378:metabolism; D011522:Protons; D012964:Sodium / Q000378:metabolism; D017923:Sodium-Hydrogen Exchangers
D002352:Carrier Proteins; D011522:Protons; D017923:Sodium-Hydrogen Exchangers; D012964:Sodium