Ca(2+)-transport ATPases and their regulation in muscle and brain.
Eukaryotic cells express one or more isoforms of a sarco(endo)plasmic reticulum (SERCA) and of a plasma membrane (PMCA) Ca2+ pump. Both the SERCA and PMCA gene transcripts are subject to alternative processing in a differentiation stage-dependent and tissue-dependent manner. The Ca2+ pump isoforms thus generated may present different functional properties. This is exemplified by the SERCA2a and SERCA2b isoforms which differ in their Ca2+ sensitivity. Analysis of the cDNA structures for PMCA1 predicts protein isoforms with variant calmodulin- and phospholipid-binding domains. A comparative study of the tissue-specific mechanisms governing SERCA-PMCA transcript processing and a more detailed study of the functional implication of the PMCA pumps isoform diversity will be challenging subjects for future studies.
Wuytack
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F
Katholieke Universiteit Leuven, Laboratorium voor Fysiologie, Belgium.
Raeymaekers
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L
De Smedt
H
H
Eggermont
J A
JA
Missiaen
L
L
Van Den Bosch
L
L
De Jaegere
S
S
Verboomen
H
H
Plessers
L
L
Casteels
R
R
D017398:Alternative Splicing; D000818:Animals; D001921:Brain / Q000201:enzymology*; D000252:Calcium-Transporting ATPases / Q000235:genetics* / Q000378:metabolism; D002462:Cell Membrane / Q000201:enzymology; D004721:Endoplasmic Reticulum / Q000201:enzymology; D015971:Gene Expression Regulation, Enzymologic; D005810:Multigene Family; D009132:Muscles / Q000201:enzymology*; D012519:Sarcoplasmic Reticulum / Q000201:enzymology; D014158:Transcription, Genetic
D000252:Calcium-Transporting ATPases