[The action of karbogal on the complement system under model conditions and in an animal experiment].
The influence of dimethylperfluorocyclohexane (carbogal) on the hemolytic activity of human blood serum complement was studied in vitro. It has been show that different effects of carbogol on the complement depend on the serum lipid composition. Endotracheal administration of carbogal to rats results in a significant reduction of complement activity in the animal's blood. Significant changes in the hemolytic activity of the complement recorded 21 days after the endotracheal administration of the compound are, probably, associated with the complement depletion after its activation by carbogal particles or with disorders in the complement component synthesis by macrophages.
Bel'tiukov
P P
PP
Boromaz
T A
TA
Galebskaia
L V
LV
Riumina
E V
EV
Sachkov
A V
AV
Shcherbak
I G
IG
D000818:Animals; D001802:Blood Substitutes / Q000008:administration & dosage / Q000494:pharmacology*; D015941:Complement Hemolytic Activity Assay; D003165:Complement System Proteins / Q000032:analysis / Q000187:drug effects*; D003510:Cyclohexanes / Q000008:administration & dosage / Q000494:pharmacology*; D005466:Fluorocarbons / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D016205:Sigmodontinae; D013997:Time Factors; D014132:Trachea
D001802:Blood Substitutes; D003510:Cyclohexanes; D005466:Fluorocarbons; C079130:dimethylperfluorocylohexane; D003165:Complement System Proteins
Vozdeĭstvie karbogala na sistemu komplementa v model'nykh usloviiakh i v éksperimente na zhivotnykh.