Blockade of GABAB receptors accelerates amygdala kindling development.
The aim of this study was to investigate the putative role of GABAB receptors in the development of amygdala kindling in rats. The effects of the GABAB blocker CGP 35348 and the GABAB agonist baclofen on the progressive development of behavioural seizure symptoms (stages 1-5 classified by Racine) and duration of after-discharges (AD) were studied. CGP 35348 at a dose of 300 mg/kg i.p., which blocks central GABAB receptors, moderately but consistently accelerated the development of behavioural seizure symptoms. CGP 35348 had no marked effect on the duration of ADs corresponding to the different seizure stages. L-baclofen (6 mg/kg i.p.) had a dual effect on kindling development. It retarded the development of the behavioural symptoms, but increased the duration of AD. In conclusion, the results suggest that synaptically-released GABA activated GABAB receptors and thereby exerted a depressant effect on kindling development.
Karlsson
G
G
Research and Development Department, Ciba-Geigy Ltd., Basel, Switzerland.
Klebs
K
K
Hafner
T
T
Schmutz
M
M
Olpe
H R
HR
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D058787:GABA-A Receptor Antagonists; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D051381:Rats
D058787:GABA-A Receptor Antagonists; D009943:Organophosphorus Compounds; C066430:CGP 35348; D001418:Baclofen