[The effect of structural analogs of ethylnorantifeine on the autophosphorylation of cAMP-independent protein kinases of neuronal chromatin].
A significant increase in autophosphorylation of cAMP-independent protein kinase No. 11 of brain neuronal chromatin occurs in the presence of ethylnorantifeine and its demethylated analog M1 rather than allyl- and propylnorantifeine. The increase is accompanied by phosphorylation of beta-regulatory and alpha-catalytic subunits of protein kinase No. 11. The nature of the direct action of antifeines on this enzyme correlates with their effects on gene activity and long-term memory storage. Whether neuronal chromatin protein kinase No. 11 is the action target of antifeines in displaying their mnemic effects is discussed in the paper.
Bogdanova
N A
NA
Kulikova
O G
OG
D000818:Animals; D002540:Cerebral Cortex / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology; D002843:Chromatin / Q000737:chemistry / Q000187:drug effects* / Q000201:enzymology; D000242:Cyclic AMP / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D005042:Etimizol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000737:chemistry / Q000187:drug effects* / Q000201:enzymology; D010766:Phosphorylation / Q000187:drug effects; D011494:Protein Kinases / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D051381:Rats
D002843:Chromatin; D000242:Cyclic AMP; D011494:Protein Kinases; D005042:Etimizol
Vliianie strukturnykh analogov étilnorantifeina na autofosforilirovanie tsAMF-nezavisimykh proteinkinaz khromatina neĭronov.