Hepatitis C virus does not cause nonalcoholic steatohepatitis.
The pathogenesis of nonalcoholic steatohepatitis (NASH) remains poorly understood. Since inflammation and fatty changes are associated with hepatitis C (HCV) infection, we have tested the role of HCV in the genesis of NASH. Five consecutive cases of classic NASH were tested by Abbott anti-c100-3 EIA and polymerase chain reaction (PCR) to detect HCV-RNA. All serum specimens were negative for anti-c100-3 (or anti-HCV EIA) and HCV PCR. Based on this study, we conclude that HCV does not play a causative or contributing role in the pathogenesis of NASH.
Rogers
D W
DW
Department of Medicine, Indiana University School of Medicine, Indianapolis 46202.
Lee
C H
CH
Pound
D C
DC
Kumar
S
S
Cummings
O W
OW
Lumeng
L
L
D000328:Adult; D000368:Aged; D001706:Biopsy; D005234:Fatty Liver / Q000097:blood / Q000209:etiology* / Q000473:pathology; D005260:Female; D016174:Hepacivirus / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D006508:Hepatitis Antibodies / Q000097:blood; D006526:Hepatitis C / Q000097:blood / Q000150:complications* / Q000473:pathology; D018937:Hepatitis C Antibodies; D006801:Humans; D007124:Immunoenzyme Techniques; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000097:blood
D006508:Hepatitis Antibodies; D018937:Hepatitis C Antibodies; D012367:RNA, Viral; C078224:anti-C100-3