Effect of phosphatidylinositol-specific phospholipase C from Bacillus thuringiensis on solid spinocellular carcinoma.
Phosphatidylinositol-specific phospholipase C (PIPLC) from Bacillus thuringiensis (0.11 units per ml) inhibited growth of IC-Sofia carcinoma cell line in culture by 64%. The growth of transplanted carcinoma in hamsters was also inhibited by 29% at a dose of 4.9 units of PIPLC/kg animal/day. In addition, degeneration processes and a significant fibrosis of the tumour occurred. The functional, clinical, biochemical and haematological parameters studied were consistent with the established antitumour effect in vivo.
Sarafov
D
D
Department of Physiology, Institute of Medicine, Plovdiv, Bulgaria.
Trifonov
B
B
Ivanov
A
A
Kamberov
E
E
Zaprjanov
Z
Z
Pavlov
P
P
Georgieva
E
E
D000818:Animals; D001413:Bacillus thuringiensis / Q000201:enzymology*; D002455:Cell Division / Q000187:drug effects*; D006224:Cricetinae; D008297:Male; D008647:Mesocricetus; D009368:Neoplasm Transplantation; D043265:Phosphatidylinositol Diacylglycerol-Lyase; D054801:Phosphoinositide Phospholipase C; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D010727:Phosphoric Diester Hydrolases; D054801:Phosphoinositide Phospholipase C; D043265:Phosphatidylinositol Diacylglycerol-Lyase