title: Dose-dependent vitamin D3, 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3-induced hypercalcemia and hyperphosphatemia, and the correlative changes in the activity of ultimobranchial and parathyroid glands of the toad, Bufo andersoni Boulenger.
abstract: Vitamin D3, 25(OH) vitamin D3 and 1,25 (OH)2D3 were administered daily to unfed male Bufo andersoni for 15 days which resulted in a significant hypercalcemia and hyperphosphatemia in a dose-dependent fashion. 1,25(OH)2D3 is more potent than the other metabolites. The treatment activated ultimobranchial gland but induced degenerative changes in parathyroid of the toads.
authors.affiliation: The National Academy of Sciences, Allahabad, India.
authors.forename: K
authors.initials: K
authors.lastname: Swarup
authors.forename: A K
authors.initials: AK
authors.lastname: Pandey
authors.forename: N
authors.initials: N
authors.lastname: Hasan
authors.forename: V K
authors.initials: VK
authors.lastname: Das
mesh_terms: D000818:Animals; D002025:Bufonidae; D002112:Calcifediol / Q000494:pharmacology*; D002117:Calcitriol / Q000494:pharmacology*; D002118:Calcium / Q000097:blood; D002762:Cholecalciferol / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006934:Hypercalcemia / Q000097:blood / Q000139:chemically induced*; D008297:Male; D010280:Parathyroid Glands / Q000187:drug effects / Q000378:metabolism*; D010710:Phosphates / Q000097:blood*; D014460:Ultimobranchial Body / Q000187:drug effects / Q000378:metabolism*
chemical_list: D010710:Phosphates; D002762:Cholecalciferol; D002117:Calcitriol; D002112:Calcifediol; D002118:Calcium