[The acquisition in dogs of temporal regulation by differentiated reinforcement of the response duration using an exteroceptive component and the pharmacological modulation of this reflex (diazepam, clozapine)].
Transformation of expectation phenomenon into the phenomenon of temporal regulation is usually achieved by the suppression of preliminary factors or by means of their physical modification. Our studies show that such transformation can be obtained in dogs using Kupalov paradigm with the presentation of additional stimuli. These stimuli strictly identical, from the physical point of view, to the signals which interrupt expectation are randomly introduced into the temporal limit. Absence of the reinforcement in response to the additional stimulus impels the animal to include temporal regulation in its behaviour, and an additional negative discriminative stimulus promotes an expression of active character of inhibition. These circumstances make our pattern closer to DRRD (differential reinforcement of response duration). In order to evaluate the merits of this procedure the influence was studied of anxiolytic (diazepam) and neuroleptic (closepine) on the stabilized reaction of experimental animals. The increase of responses duration by closepine and their shortening by diazepam as well as the influence of these pharmacological substances on the frequency of responses in dependence of dose, confirm the results of the previous studies of DRRD and DRL (differential reinforcement of low rate of responses) and prove differential sensitivity of our procedure to pharmacological substances.
Bruviller
J
J
Department of Physiology, Medical Faculty of University, Namur, Belgium.
Chleid
E
E
Guer
H
H
Mersier
M
M
D000818:Animals; D003024:Clozapine / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D003975:Diazepam / Q000494:pharmacology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007266:Inhibition, Psychological; D008297:Male; D011434:Proprioception / Q000187:drug effects / Q000502:physiology*; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology*; D012054:Reinforcement, Psychology; D013997:Time Factors; D013998:Time Perception / Q000187:drug effects / Q000502:physiology*
D003024:Clozapine; D003975:Diazepam
Vyrabotka u sobak vremennóĭ reguliatsii putem differentsirovannogo podkrepleniia dlitel'nosti otveta s ispol'zovaniem éksterotseptivnogo komponenta i farmakologicheskaia moduliatsiia étogo refleksa (diazepam, klozepin).