[A simultaneous study of intestinal permeability and the test of H2 in the expired breath of celiac children].
Permeability test with sugars (PTS) as a non-invasive diagnostic tool is of special interest in pediatric patients. This study evaluated the relationship between PTS and antigliadin antibodies (AA) with the intestinal biopsy and studied whether an altered expired hydrogen test (EHT) could interfere in this relation in celiac patients. Thirty children (13 girls, 17 boys) with diagnosis of celiac disease (ESPGAN criteria) were divided into three groups according to this histopathology: Group A (n = 23) normal biopsy; Group B (n = 7) biopsy grade III or IV; Group C (n = 25) controls. The intestinal permeability test showed significative differences (p < 0.01) of Group B (0.159 +/- 0.03) with Group A (0.048 +/- 0.005) and with the control Group C (0.039 +/- 0.002). The cut-off for the Youden maximum index (0.75) was 0.092 and ROC SE 0.87 +/- 0.7. The results of the AA were related to those of the PTS. The variance analysis showed that the results of the expired hydrogen test do not interfere statistically on the good correlation of PTS with the histology. The PTS is a good indicator of the status of intestinal mucosa. There is a good correlation between PTS and AA in celiac children. A pathological expired hydrogen test seems not to interfere with the correlation found between PTS and histological damage in our series.
Marina
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O
Servicio de Gastroenterología y Nutrición Infantil, Hospital Infantil La Paz, Madrid, España.
Fernández-Calle
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P
Codoceo
R
R
Martín
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M
Polanco
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I
D000293:Adolescent; D000704:Analysis of Variance; D001706:Biopsy; D001944:Breath Tests; D002446:Celiac Disease / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*; D002463:Cell Membrane Permeability; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006859:Hydrogen / Q000032:analysis*; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000473:pathology; D007792:Lactulose; D008297:Male; D012210:Rhamnose
D007792:Lactulose; D006859:Hydrogen; D012210:Rhamnose
Estudio simultáneo de la permeabilidad intestinal y la prueba de H2 en aire espirado en niños celíacos.