Synthesis and immunological activity of dialkyloamine- and N-piperidinederivatives of dithiocarbamic acid.
A series of aminocarbamic acid derivatives, containing fragments of substituted hydrazine and dithiocarbamic acid, was synthesized. The immunopharmacologic studies showed these that derivatives exerted immunotropic, mainly suppressive effects (PFC, circulating immunoglobulins, E-RFC, A-RFC). Some of these compounds, however, caused significant increase of weight of the popliteal lymph nodes. The immunotropic activity of the newly synthesized preparations is comparable with the action of sodium diethyldithiocarbamate (imuthiol).
Pomorski
J
J
Department of Drugs Chemistry, Medical Academy, Wrocław.
Kowalczyk-Bronisz
S H
SH
Mojsiejewska
D
D
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D004050:Ditiocarb / Q000494:pharmacology; D005260:Female; D007075:Immunoglobulin M / Q000097:blood; D007166:Immunosuppressive Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008198:Lymph Nodes / Q000187:drug effects; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D015394:Molecular Structure; D012397:Rosette Formation; D013329:Structure-Activity Relationship; D013859:Thiocarbamates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D007075:Immunoglobulin M; D007166:Immunosuppressive Agents; D013859:Thiocarbamates; D004050:Ditiocarb