title: Structure and evolution of insulins: implications for receptor binding.
abstract: Insulin is a member of a family of hormones, growth factors and neuropeptides which are found in both vertebrates and invertebrates. A common 'insulin fold' is probably adopted by all family members. Although the specificities of receptor binding are different, there is a possibility of co-evolution of polypeptides and their receptors.
authors.affiliation: Laboratory of Molecular Biology, Birkbeck College, London, UK.
authors.forename: J
authors.initials: J
authors.lastname: Murray-Rust
authors.forename: A N
authors.initials: AN
authors.lastname: McLeod
authors.forename: T L
authors.initials: TL
authors.lastname: Blundell
authors.forename: S P
authors.initials: SP
authors.lastname: Wood
mesh_terms: D001665:Binding Sites; D005075:Biological Evolution; D006133:Growth Substances / Q000737:chemistry; D007328:Insulin / Q000737:chemistry*; D009479:Neuropeptides / Q000737:chemistry; D011972:Receptor, Insulin / Q000737:chemistry*; D011956:Receptors, Cell Surface / Q000737:chemistry
chemical_list: D006133:Growth Substances; D007328:Insulin; D009479:Neuropeptides; D011956:Receptors, Cell Surface; D011972:Receptor, Insulin