title: [Peripheral neuropathy associated with Castleman's lymphoma].
abstract: Castleman's lymphoma is a rare clinicopathological entity and is often difficult to classify nosographically. From the histopathological point of view two variants are recognized, one hyalino-vascular and one plasma cellular. Moreover Castleman's lymphoma may be multifocal or unifocal (located within the thorax in 70% of patients). The plasma cellular variant is often associated with systemic symptoms such as fever, sweating, organomegaly, polyneuropathy, and mono- or polyclonal gammopathy. We describe a rare case of unifocal, plasma cellular-type Castleman's lymphoma located in the mediastinum, asymptomatic at onset but later dominated by neurological symptoms (chronic isolated polyneuropathy whose clinical expression was predominantly motor). A brief review is presented of the main clinico-histological characteristics of Castleman's lymphoma together with some hypotheses about the pathogenesis of the associated neuropathy.
authors.affiliation: Istituto di Clinica medica generale e Terapia medica, Clinica di Ematologia, Università, Ancona.
authors.forename: S
authors.initials: S
authors.lastname: Rupoli
authors.forename: F
authors.initials: F
authors.lastname: Logullo
authors.forename: P
authors.initials: P
authors.lastname: di Bella
authors.forename: S
authors.initials: S
authors.lastname: Cinti
authors.forename: M
authors.initials: M
authors.lastname: Scarpelli
authors.forename: A
authors.initials: A
authors.lastname: Cinciripini
authors.forename: L
authors.initials: L
authors.lastname: Da Lio
authors.forename: P
authors.initials: P
authors.lastname: Leoni
mesh_terms: D000328:Adult; D001706:Biopsy; D005871:Castleman Disease / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D002908:Chronic Disease; D006801:Humans; D008297:Male; D009132:Muscles / Q000473:pathology; D009460:Neurologic Examination; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D013497:Sural Nerve / Q000473:pathology
vernacular_title: Neuropatia periferica associata a linfoma di Castleman.