Regulation of intracellular cyclic AMP concentrations in hepatocytes involves the integrated activation and desensitization of adenylyl cyclase coupled with the action and activation of specific isoforms of cyclic AMP phosphodiesterase.
Houslay
M D
MD
Department of Biochemistry, University of Glasgow, U.K.
Griffiths
S L
SL
Horton
Y M
YM
Livingstone
C
C
Lobban
M
M
Macdonald
F
F
Morris
N
N
Pryde
J
J
Scotland
G
G
Shakur
Y
Y
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism*; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D004789:Enzyme Activation; D006706:Homeostasis; D007527:Isoenzymes / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000378:metabolism*
D007527:Isoenzymes; D000242:Cyclic AMP; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D000262:Adenylyl Cyclases