[Evaluation of the therapeutic activity of itraconazole in chronic infections, experimental and human, by Trypanosoma cruzi].
Other authors have demonstrated that itraconazole has antiparasitic activity against Trypanosoma cruzi both in vitro and in animal acute infection. Because of these observations, we decided to evaluate the chronic phase of this protozoal disease, since it is the most important form under a clinical and assistential point of view. We studied an infected mouse model as well as human cases of Chagas' disease. One hundred mg/kg/day by gastric tube, and 100 or 200 mg/day orally were given, respectively, during three months, without showing any beneficial effect, at least with the adopted methods.
Moreira
A A
AA
Laboratório de Investigação Médica-Parasitologia, do Hospital das Clínicas, da Faculdade de Medicina da Universidade de São Paulo, Brasil.
de Souza
H B
HB
Amato Neto
V
V
Matsubara
L
L
Pinto
P L
PL
Tolezano
J E
JE
Nunes
E V
EV
Okumura
M
M
D000328:Adult; D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008875:Middle Aged
D017964:Itraconazole
Avaliação da atividade terapêutica do itraconazol nas infecções crônicas, experimental e humana, pelo Trypanosoma cruzi.