title: Reactions of copper complexes with oxygen radicals generated by human neutrophils.
abstract: The intensity of the chemiluminescence of unstimulated human neutrophils in the presence of luminol was used to investigate the effects of low-molecular-weight copper complexes at the cellular level. In different models (superoxide dismutase mimetic activity, inhibition of haematoporphyrin derivative/light-induced lysis of cells), the biological activity of the complexes exceeded the activity of the ligands alone.
authors.affiliation: Research Institute of Molecular Pharmacology, Berlin, FRG.
authors.forename: R F
authors.initials: RF
authors.lastname: Haseloff
authors.forename: S
authors.initials: S
authors.lastname: Gruner
authors.forename: G G
authors.initials: GG
authors.lastname: Wischnewsky
mesh_terms: D003300:Copper / Q000494:pharmacology*; D017324:Hematoporphyrin Derivative; D006415:Hematoporphyrins / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008163:Luminescent Measurements; D008165:Luminol; D008722:Methods; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000097:blood; D013481:Superoxides / Q000097:blood*
chemical_list: D006415:Hematoporphyrins; D013481:Superoxides; D008165:Luminol; D017324:Hematoporphyrin Derivative; D003300:Copper; D013482:Superoxide Dismutase; D007213:Indomethacin