title: EEG findings in West syndrome a follow-up of 20 patients.
abstract: Clinical and EEG findings of 36 patients with West syndrome (WS) were reported. Twenty patients (7 males, 13 females; mean age 7.4 months at the first EEG examination) were followed for a mean period of 19.3 months. Fifty per cent of the 8 cases with cryptogenic SW showed a full recovery, 2 cases showed persistence of psychomotor retardation or seizures and 2 of both these features. At the end of follow-up period, 92% of the 12 patients with symptomatic WS showed a psychomotor retardation and 75% a persistence of seizures. EEG pattern was a typical hypsarrhythmic one in 11 patients and atypical in the remaining cases. The typical pattern correlated with a better outcome with full recovery in 27.3% compared with 11.1% in the group with atypical EEG. Moreover EEG monitoring was useful for the evaluation of therapeutic response and in the follow-up of the disease, showing a correlation with clinical course, incidence of spasms and outcome.
authors.affiliation: Department of Clinical Neurophysiology, 2nd School of Medicine, University of Naples, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Vacca
authors.forename: F A
authors.initials: FA
authors.lastname: de Falco
authors.forename: S
authors.initials: S
authors.lastname: Natale
authors.forename: E
authors.initials: E
authors.lastname: del Giudice
authors.forename: A
authors.initials: A
authors.lastname: Romano
authors.forename: F
authors.initials: F
authors.lastname: Latte
authors.forename: L
authors.initials: L
authors.lastname: Bianchi
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use; D000927:Anticonvulsants / Q000627:therapeutic use; D004569:Electroencephalography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008607:Intellectual Disability / Q000209:etiology; D008297:Male; D011596:Psychomotor Disorders / Q000209:etiology; D013036:Spasms, Infantile / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D000324:Adrenocorticotropic Hormone