Islet amyloid polypeptide-producing pancreatic islet cell tumor. A clinical and biochemical characterization.
Islet amyloid peptide (IAPP) or amylin is a recently discovered polypeptide without settled physiology in man. We present a patient with an endocrine pancreatic tumor secreting huge amounts of IAPP-like immunoreactivity (20,000 mol/l) and a concomitant development of diabetes mellitus. The release of insulin and pancreatic polypeptide (PP) was totally absent after an oral glucose load and a mixed meal, respectively. Tumor secretion of IAPP-like immunoreactivity seemed to be influenced by cholinergic mechanisms and by nutrients. The observed effects on insulin and PP secretion by high circulating levels of IAPP-like immunoreactivity may be of beneficial value for further studies of the physiology of IAPP in man.
Stridsberg
M
M
Dept. of Clinical Chemistry, Ludwig Institute for Cancer Research, Uppsala, Sweden.
Wilander
E
E
Oberg
K
K
Lundqvist
G
G
Eriksson
B
B
D007516:Adenoma, Islet Cell / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D000682:Amyloid / Q000032:analysis / Q000378:metabolism*; D002850:Chromatography, Gel; D006801:Humans; D058228:Islet Amyloid Polypeptide; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D011863:Radioimmunoassay / Q000379:methods
D000682:Amyloid; D058228:Islet Amyloid Polypeptide