[Modulation of the immune response of HSIAH strain rats with the preparations Nakom and L-dopa. Hereditary stress-induced arterial hypertension].
A morphometrical and cytological study of the iliac lymph nodes was carried out in 5-month-old rats of the NISAG strain (40 animals) given injections of distilled water and drugs L-dopa and Nakom increasing synthesis of catecholamines. Injections to rat-cubs of distilled water which was used for preparing suspensions of the drug resulted in lessening the mass of the lymph nodes in adult animals by 74% as compared with intact rats. The presence of L-dopa returned this index to the level characteristic of intact animals, and administration of Nakom gave its 62% elevation. In all the animals injected water the section area of the cortical substance was decreased while the relative square area of the medullary substance increased. The cortico-medullary index dropped by 53% which suggested a change of the lymph node type. Under the influence of L-dopa and Nakom an inclination to a one-direction reaction was noted: dilatation of marginal sinuses containing great amount of cells; change of the ratio of the medullary and cortical substance at the expense of growing paracortical zone; narrowing of the cortical plateau at the expense of newly formed secondary lymph nodules with a rather typical 2-3 raw arrangement of them. The changes were more pronounced after the administration of Nakom, greater amount of cells of the lymphoid and plasmacytic raw in all zones except the paracortical one where the portion of blasts, middle-size lymphocytes, macrophages, reticular and mitotically dividing cells became less.(ABSTRACT TRUNCATED AT 250 WORDS)
Golubeva
I A
IA
Maslova
L N
LN
Patrusheva
S V
SV
Sklianova
N A
NA
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D002230:Carbidopa / Q000494:pharmacology*; D004338:Drug Combinations; D005260:Female; D006973:Hypertension / Q000276:immunology* / Q000473:pathology; D007083:Iliac Artery; D007980:Levodopa / Q000494:pharmacology*; D008198:Lymph Nodes / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains / Q000276:immunology*; D013312:Stress, Physiological / Q000276:immunology* / Q000473:pathology
D000276:Adjuvants, Immunologic; D004338:Drug Combinations; C009265:carbidopa, levodopa drug combination; D007980:Levodopa; D002230:Carbidopa
Moduliatsiia immunnogo otveta u krys linii NISAG preparatami NAKOM i L-DOFA.