Effect of verapamil on acute coxsackievirus B3 murine myocarditis.
The effect of verapamil (Ver) on CVB3 murine myocarditis was investigated. It was found that Ver could aggravate the myocardial inflammation, increase the viral replication in myocardium, and raise mortality in mice with viral myocarditis when the drug was injected within the first 6 days after the CVB3 inoculation.
Xu
Y
Y
Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Shanghai Medical University.
Yang
Y Z
YZ
Chen
H Z
HZ
Jin
P Y
PY
Guo
Q
Q
Zhao
W Z
WZ
Yang
J H
JH
Cai
Q X
QX
Zhou
Y C
YC
D000208:Acute Disease; D000818:Animals; D003384:Coxsackievirus Infections / Q000188:drug therapy*; D029822:Enterovirus B, Human / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009205:Myocarditis / Q000188:drug therapy* / Q000382:microbiology; D014700:Verapamil / Q000494:pharmacology* / Q000627:therapeutic use; D014779:Virus Replication / Q000187:drug effects*
D014700:Verapamil