title: [Meniscal repair with autogenous periosteum and fibrin adhesive system].
abstract: It is well recognized that meniscal tear in the avascular portion is difficult to heal. The purpose of this study is to evaluate the ability of periosteum and fibrin adhesive system (FAS) in promoting the meniscal repair in the avascular zone. Full-thickness defects of 1 x 3 mm were created in the avascular portion of lateral menisci in adult mongrels. The control menisci were left without any treatment. The experimental defects were either repaired with autogenous periosteum or the combination of periosteum and FAS. Histologic and ultrastructural evaluation of the reparative tissue were compared at 4, 8, and 16 weeks postoperatively. The reparative tissue in the control group remained fibrous even at week 16, whereas that in the grafted and graft/FAS groups resembled normal adjacent fibrocartilage. Moreover, the regenerated chondrocytes in the graft/FAS group appeared more mature than those in the grafted group. Our results suggest that periosteum is a potential source of primitive cells from which chondrocytes could be differentiated and developed during the reparative process of meniscal fibrocartilage. As to FAS, it not only acted as a hemostatic agent and a fixant, but also could indirectly accelerate the chondrogenesis of periosteum in the meniscal defects. It is sufficient to conclude that the combination of periosteum and FAS in promoting meniscal defects or severe tears in the avascular portion bears its potential in future clinical application.
authors.affiliation: Department of Orthopedic Surgery, National Taiwan University Hospital.
authors.forename: C L
authors.initials: CL
authors.lastname: Tsai
authors.forename: T K
authors.initials: TK
authors.lastname: Liu
authors.forename: C N
authors.initials: CN
authors.lastname: Liu
authors.forename: A C
authors.initials: AC
authors.lastname: Lim
mesh_terms: D000818:Animals; D004285:Dogs; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D008592:Menisci, Tibial / Q000601:surgery* / Q000648:ultrastructure; D008854:Microscopy, Electron; D010521:Periosteum / Q000637:transplantation*
chemical_list: D015718:Fibrin Tissue Adhesive