Cisplatin neuropathy: clinical course and neurophysiological findings.
Sixteen patients treated with cisplatin (CDDP) 40 mg/m2 on days 1-5 every 4 weeks for three courses (cumulative dose 600 mg/m2) were clinically and neurophysiologically tested before, during and 1, 3, 6, 9 and 12 months after CDDP administration. The first symptoms of polyneuropathy occurred in 4 of 9 patients after the second course (cumulative dose 400 mg/m2). One month after treatment 1 of 9 patients was asymptomatic, 5 complained of symptoms and 3 showed clinical and neurophysiological signs of polyneuropathy. Three months after CDDP all patients were affected. Clinical and neurophysiological signs of severity progression were noted up to 6 months after treatment with CDDP.
LoMonaco
M
M
Institute of Neurology, Università Cattolica S. Cuore, Rome, Italy.
Milone
M
M
Batocchi
A P
AP
Padua
L
L
Restuccia
D
D
Tonali
P
P
D000200:Action Potentials / Q000502:physiology; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D002945:Cisplatin / Q000009:adverse effects*; D004576:Electromyography; D005260:Female; D006801:Humans; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000503:physiopathology; D011930:Reaction Time
D002945:Cisplatin