title: Argyrophilic nucleolar organizer regions in neoplastic and non-neoplastic hepatocytes bearing Mallory bodies.
abstract: The proliferative activity of Mallory bodies (MB)-positive hepatocytes (neoplastic and non-neoplastic) was examined by counting the argyrophilic nucleolar organizer regions (AgNORs). Among 19 cases of hepatocellular carcinoma, the mean number of AgNORs was lower in the MB-positive carcinoma cells than in the negative ones in nine cases, higher in six, and there was no difference in four. In non-neoplastic cases (seven cases of advanced primary biliary cirrhosis and seven cases of alcoholic or nutritional liver injury), the mean number of AgNORs was lower in the MB-positive hepatocytes than that in the negative ones in eight cases, and approximately equal in number in six cases. These findings imply that MB formation does not directly represent the level of proliferative activity of hepatocytes, regardless of whether they are malignant or not.
authors.affiliation: Second Department of Pathology, Kanazawa University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hoso
authors.forename: Y
authors.initials: Y
authors.lastname: Nakanuma
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000737:chemistry / Q000473:pathology*; D002455:Cell Division; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000737:chemistry; D008107:Liver Diseases / Q000378:metabolism / Q000473:pathology*; D008113:Liver Neoplasms / Q000737:chemistry / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009697:Nucleolus Organizer Region / Q000737:chemistry*; D016622:Silver Staining