Decrease in epinephrine-induced attenuation of platelet adenylate cyclase activity in depressed patients: relation with plasma electrolytes.
We have measured the alpha 2-adrenoceptor-mediated inhibition of platelet membrane adenylate cyclase in depressed patients and control subjects. The results showed a decrease in the forskolin-stimulated adenylate cyclase inhibition of depressed patients compared to the healthy subjects. This suggests a subsensitivity of alpha 2-adrenoceptor in depression. However, this subsensitivity was not correlated to the severity of depression as both severely and moderately depressed patients exhibited the same percent of adenylate cyclase inhibition. The antidepressant drugs treatment induced an increase in the percent of adenylate cyclase inhibition with a trend towards the control values. However, this increase did not equal control value, and moreover both remitted and unremitted patients presented a similar change in their alpha 2-adrenoceptor-mediated adenylate cyclase inhibition. This result raises the question about a simple and direct relation between the clinical status of depression and the power of alpha 2-adrenoceptor-mediated adenylate cyclase inhibition. Plasma magnesium and sodium yielded correlations to this alpha 2-adrenoceptor-mediated adenylate cyclase inhibition suggesting a relation between the platelet adrenergic function and plasma electrolytes.
Karege
F
F
Service de la Recherche Biologique et de Psychopharmacologie Clinique, Universitaires de Psychiatrie de Genève, (IUPG), Chĕne-Bourg, Switzerland.
Bovier
P
P
Widmer
J
J
Gaillard
J M
JM
Tissot
R
R
D000067956:Adenylyl Cyclase Inhibitors; D000262:Adenylyl Cyclases / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology*; D003866:Depressive Disorder / Q000201:enzymology*; D004573:Electrolytes / Q000097:blood*; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism
D000067956:Adenylyl Cyclase Inhibitors; D004573:Electrolytes; D011942:Receptors, Adrenergic, alpha; D000262:Adenylyl Cyclases; D004837:Epinephrine