Psyllium husk. I: Effect on plasma lipoproteins, cholesterol metabolism, and atherosclerosis in African green monkeys.
Psyllium's effects on plasma and lipoprotein cholesterol concentrations, cholesterol metabolism, and diet-induced atherosclerosis were studied in adult male African green monkeys (Cercopithecus aethiops). Animals were fed for 3.5 y one of three experimental diets: low-cholesterol cellulose (LCC), high-cholesterol cellulose (HCC), or high-cholesterol psyllium (HCP). The LCC and HCP groups had significantly (P less than 0.05) lower plasma cholesterol concentrations (39% lower) at 1 mo than did the HCC group. These responses persisted throughout the study. Plasma cholesterol changes were due to a reduction in intermediate-density and low-density lipoproteins; very-low and high-density-lipoprotein concentrations were similar among groups. Aortic atherosclerosis, evaluated as percent sudanophilia at 3.5 y, was lowest in the LCC group, intermediate in the HCP group, and highest in the HCC group. Cholesterol absorption, neutral steroid and fat excretion, HMGCoA reductase activity (in intestine and liver), and body weight were unrelated to psyllium's hypocholesterolemic effects.
McCall
M R
MR
Department of Food Science, Washington State University, Pullman.
Mehta
T
T
Leathers
C W
CW
Foster
D M
DM
D000818:Animals; D001161:Arteriosclerosis / Q000097:blood / Q000178:diet therapy* / Q000378:metabolism; D002522:Chlorocebus aethiops; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D002791:Cholesterol, Dietary / Q000008:administration & dosage / Q000493:pharmacokinetics; D004036:Diet, Atherogenic; D004043:Dietary Fiber / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005772:Gastrointestinal Transit; D006903:Hydroxymethylglutaryl CoA Reductases / Q000032:analysis; D007408:Intestinal Absorption; D007422:Intestines / Q000201:enzymology; D008074:Lipoproteins / Q000097:blood*; D008099:Liver / Q000201:enzymology; D008297:Male; D010943:Plantago; D010946:Plants, Medicinal; D011897:Random Allocation; D014280:Triglycerides / Q000097:blood
D002791:Cholesterol, Dietary; D004043:Dietary Fiber; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases