title: Sinonasal Schneiderian papillomas: human papillomavirus typing by polymerase chain reaction.
abstract: A series of 35 formalin-fixed, paraffin-embedded Schneiderian papillomas (24 inverted, nine cylindrical cell type, and two fungiform) of the nasal cavity were evaluated for the presence of human papillomavirus (HPV) types 6b/11, 16, and 18 DNA sequences using both a highly sensitive and specific modification of the polymerase chain reaction technique and conventional in situ hybridization. The HPV gene sequences (E6-E7 portions) were not detected in any of the 24 inverted or nine cylindrical cell papillomas. One of the fungiform papillomas was positive for HPV 6b/11. We conclude: (a) the origin of most Schneiderian sinonasal papillomas is not associated with HPV infection of these common types, and (b) fungiform papilloma is a distinctive clinicopathologic subtype of Schneiderian papilloma that may be HPV-related.
authors.affiliation: Department of Pathology, Wayne State University, School of Medicine, Detroit, Michigan.
authors.forename: F H
authors.initials: FH
authors.lastname: Sarkar
authors.forename: D W
authors.initials: DW
authors.lastname: Visscher
authors.forename: E B
authors.initials: EB
authors.lastname: Kintanar
authors.forename: R J
authors.initials: RJ
authors.lastname: Zarbo
authors.forename: J D
authors.initials: JD
authors.lastname: Crissman
mesh_terms: D001483:Base Sequence; D015344:DNA Probes, HPV; D004279:DNA, Viral / Q000737:chemistry*; D006801:Humans; D008969:Molecular Sequence Data; D009300:Nasal Septum; D009669:Nose Neoplasms / Q000382:microbiology* / Q000473:pathology; D010212:Papilloma / Q000382:microbiology* / Q000473:pathology; D027383:Papillomaviridae / Q000145:classification* / Q000302:isolation & purification; D010255:Paranasal Sinus Neoplasms / Q000382:microbiology / Q000473:pathology; D016133:Polymerase Chain Reaction
chemical_list: D015344:DNA Probes, HPV; D004279:DNA, Viral