[Nitrogen oxide is not an agent of endothelium-mediated arterial dilatation to an increase in the blood flow rate].
I. v. administration of inhibitors of endothelium-mediated synthesis of the oxide of nitrogen raised the arterial blood pressure, constricted the femoral artery and decreased the acetylcholine- and ATP-induced vaso-dilatation in anesthetized cats. However, the dilatation induced by an increased blood flow velocity, was not affected. The data obtained suggest that the endothelium-dependent arterial dilatation is not mediated by oxide of nitrogen formed from L-arginine.
Mel'kumiants
A M
AM
Balashov
S A
SA
Klimachev
A N
AN
Kartamyshev
S P
SP
Khaiutin
V M
VM
D000109:Acetylcholine / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002415:Cats; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D005263:Femoral Artery / Q000187:drug effects / Q000502:physiology*; D019335:Nitroarginine; D009589:Nitrogen Oxides / Q000037:antagonists & inhibitors / Q000378:metabolism*; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*; D019323:omega-N-Methylarginine
D009589:Nitrogen Oxides; D019335:Nitroarginine; D019323:omega-N-Methylarginine; D000255:Adenosine Triphosphate; D001120:Arginine; D000109:Acetylcholine
Oksid azota ne iavliaetsia mediatorom oposreduemoĭ éndoteliem dilatatsii arteriĭ na povyshenie skorosti krovotoka.