Regional hemodynamic effects of a kinin antagonist in awake normotensive rats.
We evaluated the effects of the B2-receptor antagonist Ac-D-Arg[Hyp3,D-Phe7,Leu8]-bradykinin on mean blood pressure (MBP) and Doppler mesenteric blood flow (DMBF). The antagonist, at a dose able to completely block the hemodynamic effects of exogenous bradykinin, increased MBP by 3 +/- 1% and decreased DMBF by 12 +/- 3%. These responses persisted after pharmacological neuro-hormonal blockade. Our results suggest that the kallikrein-kinin system plays a role in the regulation of mesenteric blood flow in rats.
Madeddu
P
P
Clinica Medica and Farmacologia, Sassari University, Italy.
Anania
V
V
Parpaglia
P P
PP
Demontis
M P
MP
Varoni
M V
MV
Fattaccio
M C
MC
Glorioso
N
N
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001920:Bradykinin / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018002:Receptors, Bradykinin; D017981:Receptors, Neurotransmitter / Q000037:antagonists & inhibitors; D012039:Regional Blood Flow / Q000187:drug effects; D013152:Splanchnic Circulation / Q000187:drug effects
D018002:Receptors, Bradykinin; D017981:Receptors, Neurotransmitter; C078645:bradykinin, acetyl-Arg-Hyp(3)-Phe(7)-Leu(8)-; D001920:Bradykinin