title: [Genetic evidence corroborates Negme's hypothesis about the greater mildness of American trypanosomiasis in Chile].
abstract: Chagas disease is present in northern and central Chile. Not more than 25% of infected individuals have had a pathologic condition presumably due to Trypanosoma cruzi. The majority of individuals with chronic infectious Chagas disease in Chile are asymptomatic in contrast to what has been observed in other South American countries. Historic and paleopathologic evidences suggest that this particular behavior could be explained by a genetic adaptation of Chilean aborigines to T cruzi. Associations between ethnic admixture, presence of Chagas disease, associated cardiac pathology and 4 blood groups (ABO, MNSs, Rh and Duffy) were investigated among inhabitants of San Pedro de Atacama in northern Chile. Cardiac pathology was determined by positive serologic reactions in individuals with abnormal electrocardiographic findings. Individuals with negative serologic results had a significantly greater aboriginal admixture (88%) compared to those with positive serology (66%). This findings supports the hypothesis of genetic adaptation explaining mildness of Chagas disease in Chile.
authors.forename: M
authors.initials: M
authors.lastname: Acuña
authors.forename: F
authors.initials: F
authors.lastname: Rothhammer
authors.forename: R
authors.initials: R
authors.lastname: Moreno
authors.forename: S
authors.initials: S
authors.lastname: Barton
authors.forename: A
authors.initials: A
authors.lastname: Arribada
authors.forename: W
authors.initials: W
authors.lastname: Apt
authors.forename: E
authors.initials: E
authors.lastname: Llop
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D001789:Blood Group Antigens / Q000235:genetics; D002598:Chagas Cardiomyopathy / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics; D014355:Chagas Disease / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D002677:Chile / Q000453:epidemiology; D005787:Gene Frequency; D006801:Humans; D007199:Indians, South American / Q000235:genetics*; D008393:Marriage; D014349:Trypanosoma cruzi / Q000276:immunology
chemical_list: D000913:Antibodies, Protozoan; D001789:Blood Group Antigens
vernacular_title: Evidencias genéticas corroboran la hipótesis de Neghme sobre la mayor benignidad de la tripanosomiasis Americana en Chile.