Pathogenesis and pharmacorrection of early postresuscitation cardiac arrhythmia.
Effect of acute lethal blood loss on character and frequency of cardiac arrhythmias in postresuscitation period has been studied. Experiments were carried out on mongrel male rats resuscitated after 4- and 6-min clinical death caused by acute blood loss. Electric cardiac instability was found in early postresuscitation period. Pacemaker migration, paroxysmal ventricular tachycardia, blockades and extrasystole that lead to ventricular fibrillation were observed in 20 percent of cases. Supported by correlative analysis it has been established that the main arrhythmogenic factors are abundance of catecholamines, free fatty acids, dienic conjugates, lactate and inhibition of Ca dependent ATPase. Antiarrhythmogenic effects of antihypoxant gutimin, the beta-adrenoreceptor blocker inderal, antioxidant oxypiridin-6 were noticed after their separate administration before clinical death. The same effect of carnosine and phosphocreatine administered during resuscitation also was noticed.
Dolgikh
V T
VT
Division of Pathophysiology, Medical Institute, Omsk, Russia.
Rusakov
V V
VV
Korpacheva
O V
OV
Sudakova
A N
AN
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000209:etiology* / Q000378:metabolism; D002336:Carnosine / Q000627:therapeutic use; D004562:Electrocardiography; D006164:Guanylthiourea / Q000627:therapeutic use; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010725:Phosphocreatine / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use; D051381:Rats; D012151:Resuscitation / Q000009:adverse effects*; D014700:Verapamil / Q000627:therapeutic use
D000975:Antioxidants; D010725:Phosphocreatine; D002336:Carnosine; D011433:Propranolol; D014700:Verapamil; D006164:Guanylthiourea