title: Regressing atypical histiocytosis, a regressing cutaneous phase of Ki-1-positive anaplastic large cell lymphoma. Immunocytochemical, nucleic acid, and cytogenetic studies of a new case in view of current opinion.
abstract: BACKGROUND
  Regressing atypical histiocytosis is a rare multifocal cutaneous tumor characterized by large, spontaneously regressing, ulcerating skin nodules. Although initially self-remitting, the condition may progress to systemic lymphoma.
  
  
  METHODS
  Using material from one patient, an attempt was made to clarify the nature of this condition with immunophenotyping, genotyping, and chromosome studies.
  
  
  RESULTS
  Immunophenotyping studies indicated the condition was of T-cell lineage, although T-cell receptor gene studies showed polyclonal rearrangement. This case progressed to systemic lymphoma.
  
  
  CONCLUSIONS
  The authors believe regressing atypical histiocytosis is a regressing phase of Ki-1-positive anaplastic large cell lymphoma of the skin.
authors.affiliation: Department of Dermatology, University Hospital of Wales, Heath Park, Cardiff, United Kingdom.
authors.forename: R J
authors.initials: RJ
authors.lastname: Motley
authors.forename: B
authors.initials: B
authors.lastname: Jasani
authors.forename: A M
authors.initials: AM
authors.lastname: Ford
authors.forename: C H
authors.initials: CH
authors.lastname: Poynton
authors.forename: J E
authors.initials: JE
authors.lastname: Calonje-Daly
authors.forename: P J
authors.initials: PJ
authors.lastname: Holt
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000378:metabolism*; D000951:Antigens, Neoplasm / Q000378:metabolism*; D004273:DNA, Neoplasm / Q000378:metabolism*; D005260:Female; D015329:Gene Rearrangement, T-Lymphocyte; D015614:Histiocytosis / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D007621:Karyotyping; D017730:Ki-1 Antigen; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D016410:Lymphoma, T-Cell, Cutaneous / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D009365:Neoplasm Regression, Spontaneous / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D012333:RNA, Messenger / Q000378:metabolism; D012334:RNA, Neoplasm / Q000378:metabolism*; D012075:Remission, Spontaneous; D012871:Skin Diseases / Q000473:pathology*; D012878:Skin Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology*
chemical_list: D015703:Antigens, CD; D000951:Antigens, Neoplasm; D004273:DNA, Neoplasm; D017730:Ki-1 Antigen; D012333:RNA, Messenger; D012334:RNA, Neoplasm