[Significance of ED50 and therapeutic indexes of various radiation-protective agent groups].
Radioprotective agents are divided in 3 groups: (1) cystamine, AET, cystaphos, gammaphos, and thiogammaphos with ED50 (the dose that gives a half of the maximal protective effect) of 10(3)-10(1.6) mumol/kg and therapeutic index K = LD50/ED50 = 10(0)-10(1.6); (2) 5-methoxytryptamine, phenylephrine, serotonin, and norepinephrine with ED50 = 10(1)-10(0) mumol/kg and K = 10(1.8)-10(2,6); (3) clonidine and isoprenaline with ED50 = 10(-0.5)-10(-0.8) mumol/kg and K = 10(3)-10(4). Possible causes of these differences and advantages of low ED50 and high K are discussed.
Kulinskiĭ
V I
VI
Kovtun
V Iu
VIu
Klimova
A D
AD
Iashunskiĭ
V G
VG
D008735:5-Methoxytryptamine / Q000008:administration & dosage; D004999:Amifostine / Q000008:administration & dosage; D000818:Animals; D003000:Clonidine / Q000008:administration & dosage; D003538:Cystamine / Q000008:administration & dosage; D003539:Cystaphos / Q000008:administration & dosage; D005260:Female; D007545:Isoproterenol / Q000008:administration & dosage; D051379:Mice; D009638:Norepinephrine / Q000008:administration & dosage; D010656:Phenylephrine / Q000008:administration & dosage; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D012701:Serotonin / Q000008:administration & dosage; D000338:beta-Aminoethyl Isothiourea / Q000008:administration & dosage
D011837:Radiation-Protective Agents; D000338:beta-Aminoethyl Isothiourea; D010656:Phenylephrine; D012701:Serotonin; D008735:5-Methoxytryptamine; D007545:Isoproterenol; D004999:Amifostine; D003000:Clonidine; D003538:Cystamine; D009638:Norepinephrine; D003539:Cystaphos
Znacheniia ED50 i terapevticheskie indeksy razlichnykh grupp radioprotektorov.