[Ca2+]i effects of bradykinin B2 receptor activation in PC12 cells.
In PC12 cells, activation of B2 receptors by bradykinin promotes an elevation of cytosolic Ca2+ by two mechanisms: IP3 mediated release of Ca2+ from intracellular stores and stimulation of multiple Ca2+ influx pathways. Since these events can have different kinetics and spatial localizations they can induce diversified effects in different cell areas.
Grohovaz
F
F
B. Ceccarelli Ctr, Dept Pharmacology, University of Milano, Italy.
Zacchetti
D
D
D' Andrea
P
P
Lorenzon
P
P
Meldolesi
J
J
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D002110:Caffeine / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D002217:Carbachol / Q000494:pharmacology; D004533:Egtazic Acid / Q000494:pharmacology; D007700:Kinetics; D009414:Nerve Growth Factors / Q000494:pharmacology; D016716:PC12 Cells; D018002:Receptors, Bradykinin; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology*
D009414:Nerve Growth Factors; D018002:Receptors, Bradykinin; D017981:Receptors, Neurotransmitter; D002110:Caffeine; D004533:Egtazic Acid; D000255:Adenosine Triphosphate; D002217:Carbachol; D001920:Bradykinin; D002118:Calcium