title: Coarse-spray immunization of one-day-old broilers against enteric reovirus infections.
abstract: Coarse-spray (CS) administration of a commercial S1133 reovirus vaccine was evaluated in 1-day-old specific-pathogen-free broilers for prevention of clinical infection induced by intratracheal challenge with two enteric reovirus isolates. In Expt. 1, chickens were challenged at 4 days of age with either the 2408 or CO8 isolate. In Expt. 2, chickens were challenged at 7 days of age with either isolate. In Expt. 3, chickens were challenged at 3, 5, or 7 days of age with the 2408 isolate. In Expt. 1, vaccinated birds showed significant protection against challenge with either isolate at 4 days of age as measured by morbidity, mortality, gross lesions, and body weight. In Expt. 2, vaccinated birds showed greater protection against challenge at 7 days of age. In Expt. 3, resistance in vaccinated birds increased with time between vaccination and challenge. Vaccinated birds challenged at 3 days of age showed no significant protection, whereas vaccinated birds challenged at 5 or 7 days of age had increased resistance. This vaccine did not induce a drop in weight gain, morbidity, mortality, or microscopic lesions in the tendons.
authors.affiliation: Poultry Science Department, Auburn University, Alabama 36849-5416.
authors.forename: J J
authors.initials: JJ
authors.lastname: Giambrone
authors.forename: T
authors.initials: T
authors.lastname: Dormitorio
authors.forename: S B
authors.initials: SB
authors.lastname: Lockaby
mesh_terms: D000336:Aerosols; D000818:Animals; D002645:Chickens; D004751:Enteritis / Q000473:pathology / Q000517:prevention & control / Q000662:veterinary; D011201:Poultry Diseases / Q000473:pathology / Q000517:prevention & control*; D012087:Reoviridae / Q000276:immunology*; D012088:Reoviridae Infections / Q000473:pathology / Q000517:prevention & control / Q000662:veterinary*; D013047:Specific Pathogen-Free Organisms; D014611:Vaccination / Q000662:veterinary; D014765:Viral Vaccines / Q000008:administration & dosage
chemical_list: D000336:Aerosols; D014765:Viral Vaccines