[Antidotal effects of 2,3-dimercaptopropane-1-sulfonate sodium (DMPS) and combined with diazepam on acute poisoning caused by sodium ammonium dimethyl-2-propano-1,3-dithiosulfate monohydrate (SCD)].
In mice, DMPS (250 mg/kg, i.v.) combined with diazepam (1.25 mg/kg, i.p.) could increase LD50 of p. o. SCD 5.3 times. DMPS (62.5 mg/kg, i.v.) antagonized completely the respiratory depression and neuromuscular blockade caused by SCD(7.5 mg/kg, i.v.) in rabbits. SCD (15 mg/kg, i.v.) caused tremor, tonic convulsion and the abnormal paroxysmal discharges in EEG in rabbits. DMPS (0.5 mg/kg, i.c.v) could not eliminate the abnormal paroxysmal discharges in EEG of rabbits. DMPS (62.5 mg/kg, i.v.) combined with diazepam (5 mg/kg, i.v.) completely and rapidly antagonize these toxic symptoms and the abnormal changes in EEG.
Lu
Z Q
ZQ
Department of Pharmacology, Wenzhou Medical College.
Hu
G X
GX
Chen
Z K
ZK
D000818:Animals; D003975:Diazepam / Q000494:pharmacology / Q000627:therapeutic use*; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D007306:Insecticides / Q000506:poisoning*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011041:Poisoning / Q000188:drug therapy; D011817:Rabbits; D013463:Sulfuric Acid Esters / Q000506:poisoning*; D014494:Unithiol / Q000494:pharmacology / Q000627:therapeutic use*
D007306:Insecticides; D013463:Sulfuric Acid Esters; D014494:Unithiol; C049599:S,S'-(2-(dimethylamino)-1,3-propanediyl)thiosulfuric acid ester; D003975:Diazepam