Erythrocyte sodium-lithium countertransport in Chinese: its relationship to family history of hypertension.
Rates of sodium (Na+)-stimulated lithium (Li+) efflux (Na(+)-Li+ countertransport) and ouabain-sensitive Na+ efflux (Na+ pump) were determined in erythrocytes of Chinese normotensive and hypertensive subjects. Near-maximal rate of Na(+)-Li+ countertransport was found to be significantly higher in hypertensive than normotensive subjects. No significant difference was observed for the rate of Na+ pump between them. A second series of study involved normotensive subjects without and with hypertensive parent(s) (group A and B, respectively) and hypertensive subjects (group C). We found that the rate of Na(+)-Li+ countertransport in group A was significantly lower than that of group B and C, while no difference existed between group B and C. No significant difference was observed for the rate of Na+ pump among the three groups. Our results suggested that Na(+)-Li+ countertransport activity could be a genetic marker for essential hypertension in Chinese, similar to that as proposed in Caucasians.
Lau
Y T
YT
Department of Physiology, Chang Gung Medical College, Tao-Yuan, Taiwan, Republic of China.
Wu
D
D
Liang
H C
HC
Chen
M C
MC
D000328:Adult; D000368:Aged; D044466:Asian People; D001693:Biological Transport, Active; D002681:China; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000235:genetics; D007700:Kinetics; D008094:Lithium / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012964:Sodium / Q000097:blood*; D000254:Sodium-Potassium-Exchanging ATPase / Q000502:physiology
D008094:Lithium; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase