title: Evidence for tachykinin NK-2B-like receptors in guinea-pig alveolar macrophages.
abstract: Mammalian tachykinins dose-dependently activate guinea-pig alveolar macrophages, by interacting with tachykinin NK-2 receptors, mainly. By evaluating the effects of different NK-2 tachykinin receptor antagonists, we now provide evidence that tachykinin NK-2 receptors in guinea-pig alveolar macrophages meet the pharmacological criteria used to define the NK-2B subtype.
authors.affiliation: Dept. Pharmacology, Univ. Florence, Firenze, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Brunelleschi
authors.forename: E
authors.initials: E
authors.lastname: Ceni
authors.forename: R
authors.initials: R
authors.lastname: Fantozzi
authors.forename: C A
authors.initials: CA
authors.lastname: Maggi
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008262:Macrophage Activation / Q000502:physiology; D016676:Macrophages, Alveolar / Q000378:metabolism*; D008969:Molecular Sequence Data; D017981:Receptors, Neurotransmitter / Q000037:antagonists & inhibitors / Q000145:classification* / Q000502:physiology; D018039:Receptors, Tachykinin; D015320:Tachykinins / Q000037:antagonists & inhibitors / Q000502:physiology*
chemical_list: D017981:Receptors, Neurotransmitter; D018039:Receptors, Tachykinin; D015320:Tachykinins