The influence of bilirubin on fluidity and rotational correlation times of human erythrocyte membrane.
The effects of bilirubin on the membrane motion parameters of human erythrocyte membrane were determined by the spin labelled ESR method. It causes a decrease in the order parameter and an increase in the corresponding fluidity of the lipid molecules. Bovine serum albumin was found to inhibit effectively the effects due to bilirubin. The disturbance to the organization of membrane molecules by bilirubin as well as the protective effects of serum albumin are discussed on the basis of the experimental results.
Chen
L X
LX
National Laboratory of Natural and Biomimetic Drugs, Beijing Medical University, China.
Lu
J F
JF
Wang
K
K
D001663:Bilirubin / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000494:pharmacology*; D001665:Binding Sites; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004578:Electron Spin Resonance Spectroscopy; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000502:physiology; D005609:Free Radicals; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008560:Membrane Fluidity / Q000187:drug effects*; D008563:Membrane Lipids / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D013113:Spin Labels
D005609:Free Radicals; D008563:Membrane Lipids; D010743:Phospholipids; D013113:Spin Labels; D012710:Serum Albumin, Bovine; D001663:Bilirubin