title: Oral contraceptives and human papillomavirus infection in cervical intraepithelial neoplasia.
abstract: We report about 142 patients from whom colposcopically directed cervical punch biopsies were taken which showed condylomatous lesions with or without cervical intraepithelial neoplasia (CIN). Fifty-six (39.4%) of these women used oral contraceptives (OC) for at least two years before examination. We used DNA in situ hybridization on all biopsies for detection of human papillomavirus (HPV)-DNA. Among OC users a significant trend towards higher HPV infection rates in high grade CIN (odds ratio 2.9, P less than 0.05) was found, whereas non-users of oral contraceptives had the highest HPV infection rate in condylomatous lesions without CIN (odds ratio 0.5, P less than 0.05). Thus in OC users HPV infection was about 24 times more likely in CIN III as in condyloma, while among non-users the trend was the other way round (7-fold likelihood of HPV positivity in condyloma compared to CIN III). Other known risk factors for cervical carcinoma did not influence HPV infection rates in either group.
authors.affiliation: Second Department of Obstetrics and Gynecology, University of Vienna, Austria.
authors.forename: G
authors.initials: G
authors.lastname: Gitsch
authors.forename: C
authors.initials: C
authors.lastname: Kainz
authors.forename: M
authors.initials: M
authors.lastname: Studnicka
authors.forename: A
authors.initials: A
authors.lastname: Reinthaller
authors.forename: G
authors.initials: G
authors.lastname: Tatra
authors.forename: G
authors.initials: G
authors.lastname: Breitenecker
mesh_terms: D000367:Age Factors; D002584:Cervix Uteri / Q000473:pathology; D003218:Condylomata Acuminata / Q000139:chemically induced* / Q000473:pathology; D003276:Contraceptives, Oral / Q000008:administration & dosage / Q000009:adverse effects*; D015344:DNA Probes, HPV; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D016017:Odds Ratio; D027383:Papillomaviridae / Q000187:drug effects* / Q000302:isolation & purification; D010298:Parity; D011230:Precancerous Conditions / Q000139:chemically induced* / Q000473:pathology; D012306:Risk; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000473:pathology; D014412:Tumor Virus Infections / Q000139:chemically induced* / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000139:chemically induced* / Q000473:pathology; D014626:Vaginal Smears
chemical_list: D003276:Contraceptives, Oral; D015344:DNA Probes, HPV