Case report: severe symptomatic hyponatremia associated with lisinopril therapy.
A 63-year-old white female who was being treated for hypertension with lisinopril presented with seizures, altered mental status, and a serum sodium of 101 mEq/L. Serum sodium prior to initiation of lisinopril therapy was 137 mEq/L. The hyponatremia was corrected and did not recur after lisinopril was stopped. The hyponatremia may have been a result of polydipsia and inappropriate antidiuresis secondary to ACE-inhibitor therapy.
Subramanian
D
D
Department of Medicine, Baylor College of Medicine, Houston, Texas.
Ayus
J C
JC
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D000959:Antihypertensive Agents / Q000009:adverse effects*; D004656:Enalapril / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007010:Hyponatremia / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D017706:Lisinopril; D001523:Mental Disorders / Q000209:etiology*; D008875:Middle Aged; D012640:Seizures / Q000209:etiology*; D012964:Sodium / Q000097:blood
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D004656:Enalapril; D012964:Sodium; D017706:Lisinopril