Decreased phosphodiesterase activity in cholera toxin-induced hypersecretion in suckling rats.
During cholera toxin (CT)-induced hypersecretion in suckling rats, the rise in the intestinal cAMP concentration was found to be accompanied by a decrease in the cAMP-phosphodiesterase activity. The results suggest the involvement of phosphodiesterase (PDE) as one of the factors governing the rise of cAMP.
Aye-Kyaw
Biochemistry Division, Department of Medical Research, Yangon, Myanmar.
Kyi-Kyi-Myint
Tin-OO
Khin-Maung-U
D000818:Animals; D000833:Animals, Suckling; D002772:Cholera Toxin; D000242:Cyclic AMP / Q000032:analysis*; D003967:Diarrhea / Q000139:chemically induced / Q000201:enzymology / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000201:enzymology; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D002772:Cholera Toxin; D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases