[Effects of cytomegalovirus infection in pregnant women to fetuses: study with DNA-DNA hybridization method].
DNA of cytomegalovirus (CMV) was examined in 131 placentae and 28 umbilical blood specimens by DNA-DNA hybridization. The result revealed that CMV DNA was detected in 4 of 50 placentae from abnormal fetuses (31 fetal deaths, 19 fetal deformities). 77 placentae from normal fetuses showed negative results. One of 2 cord blood samples from fetal deformities showed CMV DNA positive. 25 umbilical blood samples from normal term newborns showed negative. 4 placentae and 1 cord blood sample from premature infants showed negative results. The results indicate that CMV may play a great role in fetal death and fetal deformity through the infected maternal-fetal circulation.
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Shangdong Medical University, Jinan.
D003587:Cytomegalovirus / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000382:microbiology / Q000635:transmission*; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D005312:Fetal Blood / Q000382:microbiology; D005313:Fetal Death / Q000209:etiology; D005333:Fetus / Q000002:abnormalities; D006801:Humans; D008431:Maternal-Fetal Exchange; D009693:Nucleic Acid Hybridization; D010920:Placenta / Q000382:microbiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology*
D004279:DNA, Viral