Postnatal blockade of cortical activity by tetrodotoxin does not disrupt the formation of vibrissa-related patterns in the rat's somatosensory cortex.
Neuronal activity has been shown to influence pattern formation in the visual system. In the present study, we determined whether or not this was also true in the somatosensory system by silencing the primary somatosensory cortex of rats with tetrodotoxin (TTX) for the first 7-11 days of life. Application of TTX during this period did not prevent the formation of the normal vibrissa-related pattern in S-I as visualized by either staining cortical sections for cytochrome oxidase, demonstration of the pattern with an antibody directed against serotonin, or labelling of thalamocortical axons with the carbocyanine dye, Di-I. These results indicate that neither peripherally evoked nor spontaneous activity are required for qualitatively normal pattern formation in the rat's primary somatosensory cortex.
Chiaia
N L
NL
Department of Anatomy, Medical College of Ohio, Toledo 43699.
Fish
S E
SE
Bauer
W R
WR
Bennett-Clarke
C A
CA
Rhoades
R W
RW
D000818:Animals; D003576:Electron Transport Complex IV / Q000032:analysis; D006651:Histocytochemistry; D051381:Rats; D012701:Serotonin / Q000032:analysis; D013003:Somatosensory Cortex / Q000187:drug effects* / Q000254:growth & development; D013779:Tetrodotoxin / Q000494:pharmacology*; D014738:Vibrissae / Q000294:innervation*
D012701:Serotonin; D013779:Tetrodotoxin; D003576:Electron Transport Complex IV