title: Influence of T-actemodulin on herpes simplex virus infection.
abstract: The aim of the investigation was to study the direct influence of T-actemodulin (TAM) on the Herpes Simplex Virus (HSV) infection in vitro and in vivo. HSV-1 (strain Vic) and HSV-2 (strain Nissa) were used in the experiments in vitro. The experiments were performed using multicycle and singlecycle growth tests. Seventy-five patients suffering from HSV infections (labialis and genitalis) were locally treated by 0.04% TAM-containing hydrophilic gel or water-washable cream (applied every 3 h). The results showed that TAM: decreased the infectious virus titre; reduced the infectious virus yield at the end of the single cycle of the virus replication; prolonged the latent period; and exerted an irreversible inhibitory effect on the infectious virus titre when applied at immediate early intervals after the infection. No relapses were observed in 84% of the patients treated with TAM. Eight percent of the patients were with only reduced relapses and in 8% of the patients TAM had a mild effect. TAM exerted a preventive effect against the disease when the treatment was initiated in the period of paresthesia.
authors.affiliation: Laboratory of Virology, Faculty of Biology, University Sofia, Bulgaria.
authors.forename: T
authors.initials: T
authors.lastname: Varadinova
authors.forename: M
authors.initials: M
authors.lastname: Trashlieva
authors.forename: Z
authors.initials: Z
authors.lastname: Kemileva
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002478:Cells, Cultured; D002648:Child; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D005260:Female; D006558:Herpes Genitalis / Q000188:drug therapy; D006560:Herpes Labialis / Q000188:drug therapy; D006561:Herpes Simplex / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011817:Rabbits; D018139:Simplexvirus / Q000187:drug effects; D013949:Thymus Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013951:Thymus Hormones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D013949:Thymus Extracts; D013951:Thymus Hormones