[A comparative study of cisapride versus metoclopramide in the treatment of symptomatic hiatal hernia].
Comparative study of the therapeutical effects of cisapride and metoclopramide in 50 patients with symptomatic hiatal hernia was performed. Behaviour of media before and after treatment, of resting pressure and relaxation lower esophageal sphincter, pressure of the primary wave and the number of reflux episodes with pH < 4. The group of patients treated with cisapride had a considerably higher beneficial effect (p < 0.01) than the metoclopramide-treated group. A total of 4 patients were dropped-off the study because of undesirable side effects (diarrhea 2, headache 1, and somnolence 1).
Brizuela
R
R
Servicio de Gastroenterología, Instituto Superior de Medicina Dr. Luis Díaz Soto, Ciudad de La Habana, Cuba.
Nodarse
O
O
García
I
I
León
C
C
Arus
E
E
D000293:Adolescent; D000328:Adult; D020117:Cisapride; D016001:Confidence Intervals; D004341:Drug Evaluation; D005260:Female; D006551:Hernia, Hiatal / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D010880:Piperidines / Q000009:adverse effects / Q000627:therapeutic use*; D011446:Prospective Studies
D010880:Piperidines; D008787:Metoclopramide; D020117:Cisapride
Estudio comparativo del cisapride versus metoclopramida en el tratamiento de la hernia hiatal sintomática.