Buprenorphine attenuates the effects of cocaine on adrenocorticotropin (ACTH) secretion and mood states in man.
Adrenocorticotropin (ACTH) levels in plasma increased rapidly to 105% above baseline within 5 minutes after intravenous injection of cocaine (30 mg) in cocaine-dependent men. The time course of ACTH stimulation paralleled increases in plasma cocaine levels and self-reports of salient drug effects on mood states and did not occur after placebo administration. An opioid mixed agonist-antagonist, buprenorphine (4 mg/day sublingually), suppressed the acute cocaine-induced stimulation of both ACTH and euphoria. Buprenorphine's suppression of postcocaine ACTH and euphoria were not related to differences in plasma cocaine levels or cocaine-induced alterations of cardiovascular function.
Mendelson
J H
JH
Alcohol and Drug Abuse Research Center, McLean Hospital-Harvard Medical School, Belmont, Massachusetts 02178.
Teoh
S K
SK
Mello
N K
NK
Ellingboe
J
J
D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000328:Adult; D000339:Affect / Q000187:drug effects*; D002047:Buprenorphine / Q000097:blood / Q000494:pharmacology*; D003042:Cocaine / Q000037:antagonists & inhibitors* / Q000097:blood; D005059:Euphoria / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D019966:Substance-Related Disorders / Q000523:psychology
D002047:Buprenorphine; D000324:Adrenocorticotropic Hormone; D003042:Cocaine