Direct evidence for mediation of an anticonflict effect of baclofen by GABAb receptors.
The present article reports an experiment on the effects of baclofen (0, 0.5, 1.0, and 2.0 mg/kg) on punished drinking in rats and the modification of these by delta-amino-n-valeric acid (DANVA) (0 and 10.0 mg/kg). Baclofen significantly enhanced punished drinking and this increase was abolished by DANVA, which had no intrinsic anxiogenic activity. It is concluded that GABAb receptors probably mediate this effect of baclofen and that such receptors may be a potential site of anxiolytic drug action.
Shephard
R A
RA
Behavioural Analysis and Behavioural Biology Research Centre, University of Ulster Jordanstown Newtownabbey, Northern Ireland, UK.
Wedlock
P
P
Wilson
N E
NE
D000596:Amino Acids / Q000494:pharmacology; D021542:Amino Acids, Neutral; D000818:Animals; D001007:Anxiety / Q000139:chemically induced* / Q000503:physiopathology; D001418:Baclofen / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D003220:Conflict, Psychological; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000145:classification / Q000187:drug effects* / Q000502:physiology
D000596:Amino Acids; D021542:Amino Acids, Neutral; D011963:Receptors, GABA-A; C013809:5-aminovaleric acid; D001418:Baclofen