[Dynamics of bioelectric activity of the brain and erythrocyte ultrastructure after intravenous infusion of sodium bicarbonate to oncologic patients].
23 patients with malignant tumors of different location and histogenesis were investigated. There were no metastases in 9 cases. 10 patients had metastases in regional areas and 4--distant. The results were compared with those obtained in 4 patients with nonmalignant diseases. EEG, blood gases, plasma acid--base balance and ultrastructure of erythrocytes were explored before and after intravenous infusion of 4.2% sodium bicarbonate solution. The metabolic alkalosis induced amelioration of EEG, which was changed basically, the condense of pre-membrane layer disappeared or decreased in erythrocytes, and disaggregation of erythrocytes took place in cancer patients vs those with nonmalignant tumors. The results confirm the suggestion of generalized intracellular acidosis in malignant tumor patients. This acidosis can be temporarily avoided or diminished artificially by blood alkalosis.
Davydova
I G
IG
Kassil'
V L
VL
Raĭkhlin
N T
NT
Filippova
N A
NA
D000138:Acidosis / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D000293:Adolescent; D000328:Adult; D001639:Bicarbonates / Q000008:administration & dosage / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D004569:Electroencephalography; D004912:Erythrocytes / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism / Q000503:physiopathology*; D012964:Sodium / Q000008:administration & dosage / Q000494:pharmacology*; D017693:Sodium Bicarbonate
D001639:Bicarbonates; D017693:Sodium Bicarbonate; D012964:Sodium
Dinamika bioélektricheskoĭ aktivnosti golovnogo mozga i ul'trastruktura éritrotsitov pri vnutrivennoĭ infuzii gidrokarbonata natriia u onkologicheskikh bol'nykh.