title: Human herpesvirus 6 (HHV-6) infection in the central nervous system.
abstract: Human herpesvirus 6 (HHV 6) was isolated from patients with exanthema subitum (ES) with a high frequency, and it is now believed that this virus causes ES as a primary infection in childhood. HHV 6 infection is highly prevalent in early childhood and this virus may infect infants through the saliva mainly from mother to child. HHV 6 has a tropism to CD4+ cells and destroys cells in vitro. Although children recover from ES without any sequelae, neurological symptoms associated with exanthema subitum are often observed, and we could detect HHV 6 in the cerebrospinal fluid of ES patients. This result suggests that HHV 6 may invade the central nervous system and cause neurological symptoms.
authors.affiliation: Department of Virology, Osaka University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamanishi
authors.forename: K
authors.initials: K
authors.lastname: Kondo
authors.forename: T
authors.initials: T
authors.lastname: Mukai
authors.forename: T
authors.initials: T
authors.lastname: Kondo
authors.forename: H
authors.initials: H
authors.lastname: Nagafuji
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: T
authors.initials: T
authors.lastname: Okuno
authors.forename: T
authors.initials: T
authors.lastname: Kurata
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis / Q000276:immunology; D001927:Brain Diseases / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000382:microbiology*; D002555:Cerebrospinal Fluid / Q000382:microbiology*; D002675:Child, Preschool; D003588:Cytopathogenic Effect, Viral / Q000276:immunology; D005077:Exanthema Subitum / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000382:microbiology; D005455:Fluorescent Antibody Technique; D006566:Herpesviridae Infections / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000382:microbiology; D015654:Herpesvirus 6, Human / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D066298:In Vitro Techniques; D007223:Infant; D003294:Seizures, Febrile / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000382:microbiology
chemical_list: D000914:Antibodies, Viral