[Monoclonal antibody A12 against gastric cancer produced in immuno-reconstituted nude mice].
A monoclonal antibody (mAb) A12 against gastric cancer was prepared in immuno-reconstituted nude mice from human ductal adenocarcinoma of stomach, Sy86B. mAb A12 could react with the majority of gastric cancer tissues (24/27-88.9%) but only cross react with a few normal tissues tested. The corresponding antigen of mAb A12 (antigen A12) was expressed at higher levels and usually in more than 50% of the cancer cells. mAb A12 may be a valid preparation in targeting therapy of gastric cancer. Preliminary analysis of antigen A12 showed that it is a oncofetal antigen probably of glycolipid or glycoprotein in nature.
Wei
S M
SM
Beijing Institute for Cancer Research.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000276:immunology* / Q000473:pathology; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D013274:Stomach Neoplasms / Q000276:immunology* / Q000473:pathology
D000911:Antibodies, Monoclonal