Erythrocyte Ca, Na/K-ATPase in long-term streptozotocin diabetic rats. Effect of good glycemic control and a Ca antagonist.
This study evaluated the effect of chronic hyperglycemia on erythrocyte membrane Ca and Na/K-ATPase activities in streptozotocin-induced diabetic rats. The activity of Ca-ATPase was significantly lower in diabetic than in normal rats. Good glycemic control by insulin restored the Ca-ATPase activity to normal. By contrast, diltiazem, a calcium entry blocker, had no effect on the enzyme activity. Calmodulin stimulated Ca-ATPase activity in all groups of rats. Na/K-ATPase activity was not altered in diabetic rats, and no effects of either insulin or diltiazem treatments were observed. The results suggest that erythrocyte Ca-ATPase activity is decreased in diabetic rats and is normalized by good glycemic control.
Reddi
A S
AS
Department of Medicine, University of Medicine and Dentistry of New Jersey--New Jersey Medical School, Newark 07103.
Dasmahapatra
A
A
Jyothirmayi
G N
GN
Jayasundaramma
B
B
D000818:Animals; D001786:Blood Glucose / Q000032:analysis* / Q000187:drug effects / Q000502:physiology; D002118:Calcium / Q000037:antagonists & inhibitors*; D000252:Calcium-Transporting ATPases / Q000097:blood*; D002147:Calmodulin / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000188:drug therapy* / Q000201:enzymology; D004110:Diltiazem / Q000494:pharmacology / Q000627:therapeutic use*; D004912:Erythrocytes / Q000201:enzymology*; D006442:Glycated Hemoglobin / Q000032:analysis; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood*; D013311:Streptozocin; D013997:Time Factors
D001786:Blood Glucose; D002118:Calcium; D000252:Calcium-Transporting ATPases; D002147:Calmodulin; D004110:Diltiazem; D006442:Glycated Hemoglobin; D000254:Sodium-Potassium-Exchanging ATPase; D013311:Streptozocin