Transmembrane protein oligomers of caprine arthritis-encephalitis lentivirus are immunodominant in goats with progressive arthritis.
To dissect mechanisms of caprine arthritis-encephalitis lentivirus-induced arthritis, an undefined immunodominant viral glycoprotein, gp90 (G. C. Johnson, A. F. Barbet, P. Klevjer-Anderson, and T. C. McGuire, Infect. Immun. 41:657-665, 1983), was characterized. Monoclonal antibody to gp90 and specific antiserum to env gene products demonstrated that gp90 was a transmembrane protein (TM) dimer. Goats with progressive arthritis had high antibody titers to oligomeric and monomeric (38-kDa) TM.
McGuire
T C
TC
Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman 99164-7040.
Knowles
D P
DP
Davis
W C
WC
Brassfield
A L
AL
Stem
T A
TA
Cheevers
W P
WP
D000818:Animals; D000911:Antibodies, Monoclonal; D001168:Arthritis / Q000209:etiology / Q000276:immunology / Q000662:veterinary; D016088:Arthritis-Encephalitis Virus, Caprine / Q000276:immunology*; D015686:Gene Products, env / Q000276:immunology*; D006023:Glycoproteins / Q000276:immunology*; D006031:Glycosylation; D015511:Goat Diseases; D006041:Goats; D016056:Immunodominant Epitopes; D016180:Lentivirus Infections / Q000276:immunology*; D014764:Viral Proteins / Q000276:immunology*
D000911:Antibodies, Monoclonal; D015686:Gene Products, env; D006023:Glycoproteins; D016056:Immunodominant Epitopes; D014764:Viral Proteins