Erythrocyte response to Trypanosoma brucei in experimentally infected dogs.
Trypanosoma brucei infection produced an acute and fatal disease in Nigerian mongrel dogs due to a rapidly developing anaemia. Infected dogs responded with increased reticulocytosis, which was not sustained with chronicity. In comparison the response to artificially-induced haemolytic anaemia was progressive, marked and sustained. The anaemia of T. brucei infection of dogs was either normocytic normochromic in acute infection or microcytic normochromic in chronic infection. Artificially-induced haemolytic anaemia was either macrocytic normochromic or normocytic normochromic. The erythropoietic potential of plasma in vivo in mice increased in T. brucei-infected dogs except at the terminal parasitaemia. The anaemia in Trypanosoma brucei-infected dogs is therefore initially responsive but becomes poorly involved with chronicity.
Omotainse
S O
SO
Nigerian Institute for Trypanosomiasis Research, Plateau State.
Anosa
V O
VO
D000818:Animals; D004283:Dog Diseases / Q000097:blood* / Q000469:parasitology; D004285:Dogs; D004912:Erythrocytes / Q000469:parasitology*; D051379:Mice; D009549:Nigeria; D013997:Time Factors; D014346:Trypanosoma brucei brucei; D014353:Trypanosomiasis, African / Q000097:blood / Q000469:parasitology / Q000662:veterinary*