title: Cytomegalovirus retinitis complicated by optic neuropathy: a longitudinal study.
abstract: Two cases of suspected cytomegalovirus (CMV) retinitis treated with ganciclovir and followed for 18 and 5 months are presented. Each patient developed optic neuropathy and experienced reduced vision despite effective control of their retinitis. In addition to objective ocular findings, subjective visual function changes (perimetry, contrast sensitivity and accommodation) in long term follow up of AIDS patients are reported for the first time. A discussion of CMV, its treatment and complications follows.
authors.affiliation: VA Medical Center, Kansas City, MO 64128.
authors.forename: T
authors.initials: T
authors.lastname: Harkins
authors.forename: J H
authors.initials: JH
authors.lastname: Maino
mesh_terms: D000065:Accommodation, Ocular; D000328:Adult; D015350:Contrast Sensitivity; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000188:drug therapy; D015828:Eye Infections, Viral / Q000150:complications* / Q000188:drug therapy; D005654:Fundus Oculi; D015774:Ganciclovir / Q000627:therapeutic use; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000150:complications*; D012173:Retinitis / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D014794:Visual Fields
chemical_list: D015774:Ganciclovir