Effect of dexfenfluramine on energy expenditure in man.
A short review has been made of the experimental studies performed in man, in which the effect of dexfenfluramine (D-F) on resting energy expenditure has been explored. It appears that the extent to which D-F possesses thermogenic properties (in addition to its anorectic effect) still remains controversial. Some investigators found either no significant increase in energy expenditure in response to the drug or a moderate effect in post-absorptive and/or postprandial state. It may be reasonable to assume that the supplementary weight loss observed with D-F as compared to a placebo can be primarily attributed to its anorectic effect rather than to its putative thermogenic effect.
Schutz
Y
Y
Institute of Physiology, Faculty of Medicine, University of Lausanne, Switzerland.
Munger
R
R
Dériaz
O
O
Jéquier
E
E
D000328:Adult; D001481:Basal Metabolism / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects*; D005260:Female; D005277:Fenfluramine / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009765:Obesity / Q000188:drug therapy / Q000378:metabolism
D005277:Fenfluramine