Inhibitory effects of dihydroagarofuran sesquiterpenes on Epstein-Barr virus activation.
To search for possible antitumor promoters, we carried out a primary screening of thirty-seven dihydroagarofuran sesquiterpenes from Tripterygium wilfordii Hook fil. var. regelii Makino and Euonymus sieboldianus Blume, using their possible inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation which is induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. Some of these sesquiterpenes, triptofordin F-2 (Takaishi et al., 1988), 1,2,6,8,15-pentaacetoxy-9-benzoyloxy-4-hydroxy-beta-dihydroagarofuran and triptogelin A-1 (Takaishi et al., 1990) were observed to significantly inhibit the EBV-EA activation at low doses. Based on the results, the structural requirements for the activity of these compounds were discussed [corrected].
Takaishi
Y
Y
Faculty of Pharmaceutical Sciences, University of Tokushima, Japan.
Ujita
K
K
Tokuda
H
H
Nishino
H
H
Iwashima
A
A
Fujita
T
T
D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000956:Antigens, Viral / Q000187:drug effects*; D002051:Burkitt Lymphoma / Q000188:drug therapy; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004854:Herpesvirus 4, Human / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D012717:Sesquiterpenes / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D016588:Anticarcinogenic Agents; D000956:Antigens, Viral; C033305:Epstein-Barr virus early antigen; D012717:Sesquiterpenes