Preparation and stability of a radioiodinated pentamidine isethionate analog.
Iodopentamidine isethionate was heated for 70 min with [I-123]- or [I-125]-sodium iodide and ammonium sulphate in the absence of solvent at 140 degrees C. The product, [I-123]- or [I-125]-iodopentamidine isethionate, was purified by ion exchange chromatography. It was stable at room temperature in aqueous solution over several days, in human blood in vitro for at least 24 h (showing no binding to either cells or proteins), in urine over at least 15 h, and during nebulization in both ultrasonic and jet nebulizers.
Blower
P J
PJ
Nuclear Medicine Department, Kent and Canterbury Hospital, England.
Smith
C M
CM
Smith
R J
RJ
Moores
G E
GE
O'Doherty
M J
MJ
D000336:Aerosols; D001769:Blood; D001992:Bronchoalveolar Lavage Fluid; D004355:Drug Stability; D006801:Humans; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D007553:Isotope Labeling / Q000379:methods*; D010419:Pentamidine; D014556:Urine
D000336:Aerosols; D007457:Iodine Radioisotopes; D010419:Pentamidine