The influence of normobaric hyperoxia on anti-oxidant enzymes activities and peroxidation product levels in rat lungs.
The aim of this study was to investigate superoxide dismutase, glutathione peroxidase, glutathione reductase, catalase and glucose-6-phosphate dehydrogenase as well as malondialdehyde, conjugated dienes and hydroperoxide levels in rat lungs after 12-, 24-, and 48-h normobaric hyperoxia. It was stated that activities of the above-mentioned enzymes and peroxidation products are increased as early as after 12 hours of hyperoxia. It is suggested that normobaric hyperoxia can induce anti-oxidant enzymes and lipid peroxidation as early as in 12th hour of hyperoxia.
Ledwozyw
A
A
Department of Pathophysiology, Agricultural University, Lublin, Poland.
Borowicz
B
B
D000818:Animals; D002374:Catalase / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D007527:Isoenzymes / Q000378:metabolism; D007700:Kinetics; D015227:Lipid Peroxidation / Q000187:drug effects*; D008168:Lung / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010100:Oxygen / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D013997:Time Factors
D007527:Isoenzymes; D008315:Malondialdehyde; D005954:Glucosephosphate Dehydrogenase; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D010100:Oxygen