[The influence of epiphysectomy and melatonin on the antidepressive effect in disordered function of the beta-adrenergic mechanisms in rats].
After chronic administration of beta-adrenoblocker propranolol (1 mg/kg, 14 days) reorganization of time course of forced swimming with decrease of rhythmical index of depression was observed. Pinealectomy slightly attenuated, and melatonin (1 mg/kg) potentiated this effect. As proposed, antidepressive properties of beta-adrenoblockade primarily are not connected with pharmacological denervation of the pineal gland.
Arushanian
E B
EB
Beĭer
E V
EV
D000818:Animals; D003863:Depression / Q000503:physiopathology / Q000517:prevention & control*; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D005082:Physical Exertion / Q000187:drug effects / Q000502:physiology; D010870:Pineal Gland / Q000502:physiology* / Q000601:surgery; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000187:drug effects* / Q000502:physiology; D013550:Swimming; D013997:Time Factors
D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D008550:Melatonin
Vliianie épifizéktomii i melatonina na antidepressivnyĭ éffekt pri narushenii funktsii beta-adrenergicheskikh mekhanizmov u krys.