[Gastric emptying and metabolic acidosis. III. Study of gastric retention of a sodium citrate solution using an experimental model of metabolic acidosis in rats].
The gastric emptying of sodium citrate solution 0.25 mEq/ml was studied in rats with metabolic acidosis induced by orogastric infusion of 0.5 M ammonium chloride solution. Two control groups were used: one infused with 0.5 M sodium chloride and the other with water. The 3 solutions content was 2 ml/100 g weight of the animal. Six hours after the infusion, there was a moderate metabolic acidosis in the group with ammonium citrate. This 6 hour interval marked the beginning of the gastric emptying study. The test meal (sodium citrate 0.25 mEq/ml) was utilized containing 6 mg% red fenol as a marker. The gastric emptying of sodium citrate was studied at 5, 10, 20 and 30 minutes after the infusion, and the results showed no differences between the 3 groups. The data suggest that the duodenal receptors to pH were more effective do determine the pattern of gastric response than the acidosis.
Baracat
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Departamento de Pediatria e Núcleo de Medicina e Cirurgia Experimental da Faculdade de Ciências Médicas da Universidade Estadual de Campinas, FCM-UNICAMP, SP.
Collares
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D000136:Acid-Base Equilibrium / Q000187:drug effects / Q000502:physiology; D000138:Acidosis / Q000097:blood / Q000139:chemically induced / Q000378:metabolism*; D000643:Ammonium Chloride; D000818:Animals; D001639:Bicarbonates / Q000097:blood; D002951:Citrates / Q000378:metabolism*; D019343:Citric Acid; D004195:Disease Models, Animal; D005260:Female; D005746:Gastric Emptying; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000097:blood; D017693:Sodium Bicarbonate
D001639:Bicarbonates; D002951:Citrates; D000643:Ammonium Chloride; D019343:Citric Acid; D017693:Sodium Bicarbonate; D012964:Sodium
Esvaziamento gástrico e acidose metabólica. III. Estudo da retenção gástrica de uma soluçao de citrato de sódio, utilizando um modelo experimental de acidose metabólica em ratos.