title: Assignment of the beta-subunit of rod photoreceptor cGMP phosphodiesterase gene PDEB (homolog of the mouse rd gene) to human chromosome 4p16.
abstract: The gene encoding the beta-subunit of rod photoreceptor cGMP phosphodiesterase (gene symbol PDEB, homolog of the mouse rd gene) is mapped to human chromosome 4 using somatic cell hybrids and further localized to the chromosome band 4p16 using in situ hybridization. A mutation in the mouse gene underlies the recessive trait of retinal degeneration in the rd mouse. Thus, the human homolog is a candidate for lesions causing retinal degeneration.
authors.affiliation: Vision Genetics Center, Jules Stein Eye Institute, Los Angeles, California.
authors.forename: J B
authors.initials: JB
authors.lastname: Bateman
authors.forename: I
authors.initials: I
authors.lastname: Klisak
authors.forename: T
authors.initials: T
authors.lastname: Kojis
authors.forename: T
authors.initials: T
authors.lastname: Mohandas
authors.forename: R S
authors.initials: RS
authors.lastname: Sparkes
authors.forename: T S
authors.initials: TS
authors.lastname: Li
authors.forename: M L
authors.initials: ML
authors.lastname: Applebury
authors.forename: C
authors.initials: C
authors.lastname: Bowes
authors.forename: D B
authors.initials: DB
authors.lastname: Farber
mesh_terms: D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000235:genetics*; D000818:Animals; D005075:Biological Evolution; D002871:Chromosome Banding; D002894:Chromosomes, Human, Pair 4; D006801:Humans; D006822:Hybrid Cells; D046911:Macromolecular Substances; D051379:Mice; D010786:Photoreceptor Cells / Q000201:enzymology*
chemical_list: D046911:Macromolecular Substances; D015106:3',5'-Cyclic-GMP Phosphodiesterases