[The action of pyrogenal and endogenous pyrogen on visceral afferent systems].
Pyrogenal in the dose 5 mcg increased the adrenaline release in dogs. Interleukin-1 increased the noradrenaline release. Neither capsaicin, nor M- and N-cholinoreceptor blockade, nor pre-decentralization of the inferior mesenteric ganglion, abolished the effects. Mechanical and chemical stimuli during continuous perfusion of the colon with subliminal doses of pyrogenal increased the adrenaline release, too. A possible direct effect of endotoxins on peripheral adrenergic neurons, is discussed.
Gurin
V N
VN
Reprintseva
V M
VM
D000344:Afferent Pathways / Q000187:drug effects / Q000502:physiology; D000818:Animals; D003106:Colon / Q000294:innervation; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000378:metabolism; D005728:Ganglia, Sympathetic / Q000187:drug effects / Q000502:physiology; D007375:Interleukin-1 / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism; D011749:Pyrogens / Q000494:pharmacology* / Q000502:physiology; D014781:Viscera / Q000294:innervation*
D007375:Interleukin-1; D008070:Lipopolysaccharides; D011749:Pyrogens; C009136:pyrogenal; D009638:Norepinephrine; D004837:Epinephrine
Deĭstvie pirogenala i éndogennogo pirogena na vistseral'nye afferentnye sistemy.