title: Anti-inflammatory activity of gallic acid.
abstract: Gallic acid was found to possess antiinflammatory activity towards zymosan-induced acute food pad swelling in mice. In vitro studies on the mode of action of gallic acid revealed that this compound interferes with the functioning of polymorphonuclear leukocytes (PMNs). Scavenging of superoxide anions, inhibition of myeloperoxidase release and activity as well as a possible interference with the assembly of active NADPH-oxidase may account for the inhibition of inflammatory process by gallic acid. Structure-activity relationship analysis showed that the o-dihydroxy group of gallic acid is important for the inhibitory activity in vitro.
authors.affiliation: Research Centre for Natural Products and Phytopharmaceuticals, Faculty of Pharmacy, University of Utrecht, The Netherlands.
authors.forename: B H
authors.initials: BH
authors.lastname: Kroes
authors.forename: A J
authors.initials: AJ
authors.lastname: van den Berg
authors.forename: H C
authors.initials: HC
authors.lastname: Quarles van Ufford
authors.forename: H
authors.initials: H
authors.lastname: van Dijk
authors.forename: R P
authors.initials: RP
authors.lastname: Labadie
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology*; D005707:Gallic Acid / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008163:Luminescent Measurements; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology; D009195:Peroxidase / Q000378:metabolism; D011817:Rabbits; D017382:Reactive Oxygen Species / Q000378:metabolism; D012756:Sheep; D013329:Structure-Activity Relationship
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D017382:Reactive Oxygen Species; D005707:Gallic Acid; D009195:Peroxidase