Characterization of ACTH mediated suppression of MHC class II expression by murine peritoneal macrophages.
The effect of ACTH on the expression of major histocompatibility complex (MHC) class II (I-A) glycoprotein by murine peritoneal macrophages was evaluated. ACTH suppressed the expression of I-A by macrophages in a time- and dose-dependent manner. ACTH mediated its effect by decreasing the level of I-A mRNA. ACTH suppressed the expression of I-A by macrophages from mice that are susceptible to the in vivo growth of mycobacteria but did not affect the expression of I-A by macrophages from Mycobacterium bovis strain (BCG)-resistant mice. The concentrations of ACTH required to suppress I-A expression were greater than that required for an effect on adrenal steroid production and may be related to the localized production of ACTH by lymphocytes and macrophages.
Zwilling
B S
BS
Department of Microbiology, Ohio State University Columbus 43120-1292.
Lafuse
W P
WP
Brown
D
D
Pearl
D
D
D000324:Adrenocorticotropic Hormone / Q000502:physiology*; D000818:Animals; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010529:Peritoneal Cavity / Q000166:cytology*
D000949:Histocompatibility Antigens Class II; D000324:Adrenocorticotropic Hormone