[The role of lysosomal enzymes in the formation of destructive processes in the gastroduodenal area].
The paper reviews works by the author and his colleagues on the problem of pathogenesis of ulcer formation within the gastroduodenal area. The stomach enzymes active in weakly acid pH zone 4.0-7.0, were shown to play a major part in the mechanisms of ulcer formation. These enzymes are of lysosomal origin and the ulcer formation starts within the mucous-submucous layer's tissues. Destabilizing of the lysosomes and release of autoaggressive lysosomal enzymes occurs under the effect of excessive production of the biogenic amines histamine and serotonin. Adrenal hormones are also involved in the process of ulcer formation.
Amirov
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D000818:Animals; D004195:Disease Models, Animal; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000502:physiology; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008247:Lysosomes / Q000201:enzymology*; D010437:Peptic Ulcer / Q000201:enzymology / Q000209:etiology*
Rol' lizosomal'nykh fermentov v formirovanii destruktivnykh protsessov v gastroduodenal'noĭ zone.