Interstitial pneumonitis induced in guinea-pigs by the antigens of Periplaneta americana.
Data concerning the experimental induction in guinea-pigs of hypersensitivity pneumonitis with a cockroach antigen are presented. A glycoprotein obtained from the chitinous structures of Periplaneta americana was aerosolized daily to guinea-pigs during 12 weeks. The presence of specific antibodies (IgG) was detected by serological techniques; histopathological studies of the lungs showed interstitial infiltrates of macrophages and LT-CD8+ cells, as revealed by the MoAb used. Single non-necrotizing granulomas were characteristic from the 10th week to the end of the experiment. The results from this animal model suggest that this hypersensitivity pneumonitis is a typical delayed-type reaction due to chronic contact with the heterologous glycoproteins of P. americana.
Alonso
A
A
Allergy and Immunology Center, Clinical Hospital, Buenos Aires, Argentina.
Albónico
J F
JF
Belloti
M
M
Mouchián
K
K
Pionetti
C H
CH
Cione
D
D
D000542:Alveolitis, Extrinsic Allergic / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D000818:Animals; D000918:Antibody Specificity; D000941:Antigens / Q000008:administration & dosage / Q000302:isolation & purification; D004195:Disease Models, Animal; D006099:Granuloma / Q000473:pathology; D006168:Guinea Pigs; D007074:Immunoglobulin G / Q000097:blood; D008168:Lung / Q000473:pathology; D010526:Periplaneta / Q000276:immunology*
D000941:Antigens; D007074:Immunoglobulin G