title: Reaction of the dental pulp to hydroxyapatite.
abstract: The purpose of this study was to evaluate the action of hydroxyapatite (HA) (Osteogen HA Resorb, GBD Marketing Group Inc., Valley Stream, N.Y.) on the dental pulp of rats. Four upper molar pulps in 45 rats were exposed and capped with synthetic HA (Osteogen) with a stereoscopic microscope. Pulps capped with calcium hydroxide (Dycal, L.D. Caulk Co., Milford, Del.) served as controls. The cavities were filled with amalgam, and the molars on each side of the maxilla were protected by the placement of a pedodontic steel crown. Pulp inflammation and dentin repair were compared by histologic observations and computer image analysis after 7, 14, and 28 days. After 7 days a partial acute pulpitis were observed in specimens treated with Osteogen or Dycal. Reparative dentin formation along the pulp walls was also seen. After 14 days the pulpitis was more extensive in the Osteogen-treated teeth than in the control teeth. Dentin formation as measured by morphometric analysis was more pronounced in Osteogen-treated teeth. Neo-odontoblasts were observed after the use of both materials. After 28 days an acute inflammatory reaction was still evident in the Osteogen-treated group. A complete dentinal bridge was observed more frequently with Dycal than with Osteogen. Despite the putative abilities of HA to be osteoconductive, osteogenic, and dentinogenic, the results of this study indicate that it should not be used as a pulp-capping agent because of its tendency to cause scattered dystrophic calcification in the dental pulp, which could interfere with future endodontic treatment.
authors.affiliation: Department of Stomatology, Faculty of Dental Medicine, University of Montreal, Quebec, Canada.
authors.forename: L
authors.initials: L
authors.lastname: Jaber
authors.forename: C
authors.initials: C
authors.lastname: Mascrès
authors.forename: W B
authors.initials: WB
authors.lastname: Donohue
mesh_terms: D000818:Animals; D002126:Calcium Hydroxide / Q000494:pharmacology; D003782:Dental Pulp / Q000187:drug effects*; D003784:Dental Pulp Calcification / Q000139:chemically induced*; D003785:Dental Pulp Capping / Q000009:adverse effects*; D003809:Dentin, Secondary; D017886:Durapatite; D006882:Hydroxyapatites / Q000009:adverse effects*; D008297:Male; D008903:Minerals / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D006882:Hydroxyapatites; D008903:Minerals; C025702:Dycal; D017886:Durapatite; D002126:Calcium Hydroxide