[Clinical application of 31P MRS to malignant liver tumors--with an emphasis on evaluation of response to therapy].
Malignant liver tumors in 19 cases (13 hepatomas and 6 metastatic tumors) were studied by 31P magnetic resonance (MR) spectroscopy. Five healthy volunteers were also studied. Volume localization was performed using the ISIS sequence. Compared with normal liver, the MR spectra of malignant tumors showed an elevated phosphomonoester (PME) peak relative to beta ATP (p less than 0.005), and tumors were slightly alkaline (pH 7.32 +/- 0.08) before therapy. Nine cases of hepatomas responding to chemoembolization showed extremely reduced signal intensity of spectra. Tumor pH was compared before and after therapy in four cases that showed good response to therapy, and was elevated in all of them. Three metastatic tumors with good response showed reductions in PME and ATP after therapy. MR spectroscopy with adequate localization technique is useful in demonstrating the response of malignant tumors to therapy.
Saeki
M
M
Department of Radiology, St. Marianna University School of Medicine.
Ashida
H
H
Imamura
K
K
Fukui
A
A
Ishizuka
K
K
Kuwabara
M
M
Wakabayashi
M
M
Ishikawa
T
T
Iwabuchi
S
S
Mizuguchi
A
A
D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000628:therapy; D016461:Chemoembolization, Therapeutic; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000556:secondary / Q000628:therapy; D009682:Magnetic Resonance Spectroscopy; D012189:Retrospective Studies