Detection of human papillomavirus (HPV) DNA type 6/11 in a conjunctival papilloma by in situ hybridization with biotinylated probes.
Four cases of conjunctival papilloma in two different patients were examined by in situ hybridization for HPV DNA type 6/11, 16/18 and 31/33/51. Formalin-fixed and paraffin-embedded tissues were hybridized by biotinylated probes. One tumor and one of its recurrences showed nuclear positivity for HPV 6/11 in the superficial cells of the epithelium. The results suggest that HPV type 6/11 may be etiologic agent of conjunctival papillomas. The benign behavior of these neoplasms may be related to the etiologic role of this type of HPV.
Mincione
G P
GP
Istituto di anatomia e istologia patologica, Università di Firenze.
Taddei
G L
GL
Wolovsky
M
M
Calzolari
A
A
Mincione
F
F
D000293:Adolescent; D000328:Adult; D001710:Biotin; D003230:Conjunctival Neoplasms / Q000737:chemistry / Q000382:microbiology*; D015344:DNA Probes, HPV; D004273:DNA, Neoplasm / Q000032:analysis*; D004279:DNA, Viral / Q000032:analysis*; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D009364:Neoplasm Recurrence, Local; D010212:Papilloma / Q000737:chemistry / Q000382:microbiology*; D027383:Papillomaviridae / Q000145:classification / Q000302:isolation & purification* / Q000472:pathogenicity
D015344:DNA Probes, HPV; D004273:DNA, Neoplasm; D004279:DNA, Viral; D001710:Biotin