title: Loss of transformed phenotype upon senescence of Rous sarcoma virus-infected chicken neuroretinal cells.
abstract: Success in obtaining permanent Rous sarcoma virus-infected chicken cell lines has been limited because of a senescence phenomenon. We show that a diminished, transformed phenotype, followed by dramatic morphological changes, precedes senescence. These changes are associated with continued expression of pp60v-src, as well as specific alterations in expression of two possible phosphorylated substrates of pp60v-src.
authors.affiliation: Department of Neurobiology and Anatomy, University of Rochester Medical Center, New York 14642.
authors.forename: G M
authors.initials: GM
authors.lastname: Seigel
authors.forename: M F
authors.initials: MF
authors.lastname: Notter
mesh_terms: D000818:Animals; D001358:Avian Sarcoma Viruses / Q000502:physiology*; D015153:Blotting, Western; D002448:Cell Adhesion; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D016922:Cellular Senescence / Q000235:genetics*; D002642:Chick Embryo; D008938:Mitosis; D010641:Phenotype; D010750:Phosphoproteins / Q000378:metabolism; D012160:Retina / Q000382:microbiology*
chemical_list: D010750:Phosphoproteins