title: Arginine induced insulin release in patients with newly onset non-insulin-dependent diabetes mellitus.
abstract: To examine the release of insulin in response to oral glucose, intravenous glucagon and intravenous arginine, we measured the levels of plasma glucose, immuno-reactive insulin (IRI) and C-peptide levels on fasting and following an oral glucose loading (OGTT), intravenous glucagon (GON) and arginine (ARG) infusion test in nine newly diagnosed non-insulin dependent diabetics. Their ages ranged from 38 to 65. The fasting plasma glucose and hemoglobin A1c levels were 240 +/- 14 mg/dl (Mean +/- SEM) and 10.7 +/- 0.54%, respectively. Mean values of the peak C-peptide/fasting C-peptide ratio and peak IRI/fasting IRI ratio were significantly increased, as compared with the basal level (P < 0.05), but not significantly different from those of the OGTT, GON and ARG test. In conclusion, the effect of arginine-induced insulin secretion in non-insulin dependent diabetes mellitus is as good as those of glucose or glucagon.
authors.affiliation: Department of Medicine, Veterans General Hospital-Taipei, R.O.C.
authors.forename: H M
authors.initials: HM
authors.lastname: Cheng
authors.forename: T S
authors.initials: TS
authors.lastname: Jap
authors.forename: K T
authors.initials: KT
authors.lastname: Lee
authors.forename: C F
authors.initials: CF
authors.lastname: Kwok
authors.forename: L T
authors.initials: LT
authors.lastname: Ho
mesh_terms: D000328:Adult; D000368:Aged; D001120:Arginine / Q000494:pharmacology*; D002096:C-Peptide / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged
chemical_list: D002096:C-Peptide; D007328:Insulin; D001120:Arginine