Metanephric adenoma.
In a recent survey of more than one hundred childhood renal tumors in our Laboratory files, we identified a unique case characterized by an unusual degree of differentiation and cell maturity. Histologically this case was notable for an orderly array of small and uniformly-packed tubules with a rosette-like configuration. The nuclei were oval, smooth and of a bland appearance. Mitoses were absent. Many glomerular figures were intermingled. This renal tumor picture is somewhat different from that known as tubular Wilms' tumor because of the well-differentiated adenomatous pattern and the absence of any blastema. The term metanephric adenoma is suggested for this tumor, which may represent the benign counterpart of Wilms' tumor.
Brisigotti
M
M
Department of Pathology, Gaslini Research Children's Hospital, Genoa, Italy.
Cozzutto
C
C
Fabbretti
G
G
Sergi
C
C
Callea
F
F
D000236:Adenoma / Q000473:pathology*; D002648:Child; D006651:Histocytochemistry; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D009396:Wilms Tumor / Q000473:pathology