[Free radicals in silicosis].
The prolonged inhalation of silicon powders induces an oxidative stress at respiratory system level, due to the formation of free radicals (FR). Free radical origin is either exogenous (as a result of the chemical structure of powders) or endogenous (result of the endocytosis of silicon powders). Bivalent Fe ions are implied in FR generation, and the substances with Fe chelating and antioxidizing actions block the evolution of silicosis.
Surcel
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Institutul de sănătate publică şi cercetări medicale, Cluj-Napoca.
D000975:Antioxidants; D004391:Dust; D005609:Free Radicals; D006801:Humans; D007501:Iron / Q000378:metabolism; D010101:Oxygen Consumption; D012825:Silicon / Q000493:pharmacokinetics; D012829:Silicosis / Q000209:etiology / Q000378:metabolism*
D000975:Antioxidants; D004391:Dust; D005609:Free Radicals; D007501:Iron; D012825:Silicon
Radicali liberi în silicoză.