title: Involvement of Ca2+ uptake by a reticulum-like store in the control of transmitter release.
abstract: At an identified neuro-neuronal synapse of Aplysia, 2,5-diterbutyl 1,4-benzohydroquinone, a selective blocker of the reticulum Ca2+ pump, was found to potentiate evoked quantal release of acetylcholine through an increased accumulation of Ca2+ in the presynaptic neuron during depolarization without any accompanying changes in the presynaptic Ca2+ current. We conclude that a rapid Ca2+ buffering system, similar to that associated with the endoplasmic reticulum, must be present in the nerve terminal and play a role in the control of Ca2+ which reaches the release system.
authors.affiliation: Laboratoire de Neurobiologie Cellulaire et Moléculaire, C.N.R.S., Gif-sur-Yvette, France.
authors.forename: P
authors.initials: P
authors.lastname: Fossier
authors.forename: G
authors.initials: G
authors.lastname: Baux
authors.forename: L E
authors.initials: LE
authors.lastname: Trudeau
authors.forename: L
authors.initials: L
authors.lastname: Tauc
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001048:Aplysia; D002118:Calcium / Q000378:metabolism*; D004533:Egtazic Acid / Q000494:pharmacology; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D005071:Evoked Potentials / Q000187:drug effects; D019835:FMRFamide; D005724:Ganglia / Q000502:physiology; D006873:Hydroquinones / Q000494:pharmacology*; D066298:In Vitro Techniques; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009479:Neuropeptides / Q000494:pharmacology; D013569:Synapses / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D000975:Antioxidants; D006873:Hydroquinones; D009479:Neuropeptides; C019359:2,5-di-tert-butylhydroquinone; D004533:Egtazic Acid; D019835:FMRFamide; D002118:Calcium