Padma 28 modifies immunological functions in experimental atherosclerosis in rabbits.
The effect of Padma 28 on selected parameters of humoral and cellular immune reactions in rabbits subjected to experimental atherosclerosis was studied. The drug significantly reduced the size of atherosclerotic plaques in the aorta and restored to a varying extent the immune functions studied. The possible mechanism by which Padma 28 may exert its anti-atherosclerotic action is discussed in the scope of the immunological theory of atherosclerosis.
Giełdanowski
J
J
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław.
Dutkiewicz
T
T
Samochowiec
L
L
Wójcicki
J
J
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology*; D001770:Blood Bactericidal Activity / Q000187:drug effects; D004036:Diet, Atherogenic; D006388:Hemagglutinins / Q000096:biosynthesis; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D010587:Phagocytosis / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D011234:Precipitins / Q000096:biosynthesis; D011817:Rabbits
D006388:Hemagglutinins; D010936:Plant Extracts; D011234:Precipitins; C066069:Padma 28