Failure of a chlordiazepoxide to reproduce the behavioral effects of muscimol administered into the basal forebrain.
Bilateral infusion of the GABAA-receptor agonist muscimol into the basal forebrain was previously found to impair visual conditional discrimination performance in rats. In order to examine whether the GABAergic input into the basal forebrain is active during performance of this task, the benzodiazepine receptor agonist chlordiazepoxide (15, 25, 40 micrograms/0.5 microliters/hemisphere) was bilaterally infused. Surprisingly, chlordiazepoxide did not affect performance. The impact of this result for the understanding of basal forebrain GABAergic functions is discussed.
Dudchenko
P
P
Department of Psychology, Ohio State University, Columbus 43210.
Sarter
M
M
D000818:Animals; D001070:Appetitive Behavior / Q000187:drug effects*; D002707:Chlordiazepoxide / Q000494:pharmacology*; D004193:Discrimination Learning / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009118:Muscimol / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects*; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D011963:Receptors, GABA-A / Q000187:drug effects*; D013377:Substantia Innominata / Q000187:drug effects*; D014796:Visual Perception / Q000187:drug effects*
D011963:Receptors, GABA-A; D009118:Muscimol; D002707:Chlordiazepoxide