Effects of lisinopril and low-dose trichlormethiazide on lipoprotein metabolism in patients with mild to moderate hypertension.
Fifty-six hypertensive patients were recruited to participate in a 12 week, randomised, multicentre trial to compare the effects of lisinopril (n = 31) and low-dose trichlormethiazide (n = 25) administration on blood pressure and lipoprotein metabolism. Both systolic and diastolic BPs decreased significantly after administration of lisinopril (5-40mg/day, mean dose 11 mg/day) and trichlormethiazide (2.0-4.0 mg/day, mean dose 2.2 mg/day). There were no significant changes in lipids, lipoproteins or apolipoproteins with either drug for 12 weeks and no significant differences between the two drugs for these parameters. It is concluded that lisinopril and low-dose trichlormethiazide administration are effective antihypertensive measures without any adverse effects after 12 weeks on lipoprotein metabolism in patients with mild to moderate essential hypertension.
Sasaki
J
J
Department of Internal Medicine, Fukuoka University Hospital, Japan.
Tominaga
K
K
Saeki
Y
Y
Kawasaki
K
K
Sumida
I
I
Ikeda
K
K
Kato
Y
Y
Doi
Y
Y
Gondo
K
K
Saku
K
K
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001053:Apolipoproteins / Q000097:blood; D001794:Blood Pressure; D002784:Cholesterol / Q000097:blood; D004151:Dipeptides / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D008074:Lipoproteins / Q000097:blood*; D017706:Lisinopril; D008875:Middle Aged; D014237:Trichlormethiazide / Q000008:administration & dosage* / Q000627:therapeutic use
D000959:Antihypertensive Agents; D001053:Apolipoproteins; D004151:Dipeptides; D008074:Lipoproteins; D002784:Cholesterol; D017706:Lisinopril; D014237:Trichlormethiazide