Cyclic pentapeptide endothelin antagonists with high ETA selectivity. Potency- and solubility-enhancing modifications.
Ishikawa
K
K
Fukami
T
T
Nagase
T
T
Fujita
K
K
Hayama
T
T
Niiyama
K
K
Mase
T
T
Ihara
M
M
Yano
M
M
D000595:Amino Acid Sequence; D003500:Cyclization; D016232:Endothelins / Q000378:metabolism; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011487:Protein Conformation; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors* / Q000378:metabolism; D017466:Receptors, Endothelin; D013329:Structure-Activity Relationship
D016232:Endothelins; D010456:Peptides, Cyclic; D011956:Receptors, Cell Surface; D017466:Receptors, Endothelin; C072247:cyclo(Trp-Asp-Pro-Val-Leu)