title: Silicone gel infiltration of a peripheral nerve and constrictive neuropathy following rupture of a breast prosthesis.
abstract: Following rupture of a subpectoral breast prosthesis, massive amounts of silicone gel migrated into the arm of a patient. The patient developed painful paresthesias and decreased sensation in the cutaneous distribution of the superficial radial nerve. Nerve conduction studies showed both an increase in distal latency and decreased amplitude in this nerve compared with the normal opposite side. Subsequent neurolysis confirmed dense fibrosis surrounding the nerve. Silicone droplets also were observed within the thickened epineurium of the median nerve, but no electrophysiologic evidence of neuropathy occurred. Multiple debridements of the subcutaneous tissue of the arm were necessary. In one of these specimens, histologic sections demonstrated silicone gel infiltration of a subcutaneous nerve. This is the first reported case of silicone gel infiltration of a nerve and constrictive neuropathy associated with a prosthesis rupture.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Medical College of Wisconsin, Milwaukee.
authors.forename: J R
authors.initials: JR
authors.lastname: Sanger
authors.forename: H S
authors.initials: HS
authors.lastname: Matloub
authors.forename: N J
authors.initials: NJ
authors.lastname: Yousif
authors.forename: R
authors.initials: R
authors.lastname: Komorowski
mesh_terms: D005260:Female; D005355:Fibrosis; D005549:Foreign-Body Reaction / Q000139:chemically induced / Q000473:pathology; D005782:Gels; D006801:Humans; D008875:Middle Aged; D009408:Nerve Compression Syndromes / Q000139:chemically induced* / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000473:pathology; D019736:Prostheses and Implants / Q000009:adverse effects*; D011475:Prosthesis Failure; D011826:Radial Nerve / Q000473:pathology*; D012828:Silicones / Q000009:adverse effects*
chemical_list: D005782:Gels; D012828:Silicones