[HLA antigens in persons with a predisposition to frequent sympathetic-adrenal paroxysms].
Comparison of the rate of HLA antigens I in 81 patients with frequently occurring sympathoadrenal paroxysms (SAP) associated with vegetovascular dystonia and 113 healthy subjects revealed the increase of the number of antigen B12 carriers among the patients as compared to the healthy subjects' group. The number of antigens A9, B35 in SAP patients was elevated whereas that of B18, B38 and B40 decreased. SAP related to age-associated hormonal rearrangements were marked by antigens Cw4 and A1, the grave SAP patterns by B12, SAP without nocturnal paroxysms and the early disease onset by the lack of antigen A19. The dominant gene that determines the onset of SAP is localizes in the HLA area. It may be associated with a hypothetical gene analogous to the locus implicated in the determination of the threshold of neuromuscular excitability of rats. It is not excluded that such a relationship is mediated via the blood content of Mg2+.
Ismagilov
M F
MF
Tananov
A T
AT
Kurmyshkin
A A
AA
D000307:Adrenal Gland Diseases / Q000453:epidemiology / Q000235:genetics / Q000276:immunology*; D000328:Adult; D001342:Autonomic Nervous System Diseases / Q000453:epidemiology / Q000235:genetics / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D004198:Disease Susceptibility / Q000453:epidemiology / Q000276:immunology; D004421:Dystonia / Q000453:epidemiology / Q000235:genetics / Q000276:immunology; D005260:Female; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000097:blood* / Q000235:genetics; D006801:Humans; D008297:Male; D013564:Sympathetic Nervous System; D013577:Syndrome
D015415:Biomarkers; D006680:HLA Antigens
Antigeny HLA u lits so sklonnost'iu k chastym simpatiko-adrenalovym paroksizmam.