title: [The conditioned-reflex mechanism of the development of tolerance for and dependence on narcotic agents].
abstract: At the beginning the term "tolerance" determinations, given in different source of literature, have been considered. Further, the history of conditioned of tolerance and abuse creation from psycho-active drugs have been discussed. The hart of the article contains the critical points of the current representation of neurophysiological theory in the field of behavior, interaction mechanisms between live systems and drugs. The point of view, dominating in pharmacology science that tolerance is the direct result of drug substances intervention into the organism, has been opposed. Separation of primary and secondary physiological effects of drugs, allowed to the authors to conclude that the dominant role belongs to the state living system and to the presence of necessities during the motivation creations for the second drug use and to the tolerance changing.
authors.forename: V L
authors.initials: VL
authors.lastname: Tsibul'skiĭ
authors.forename: V P
authors.initials: VP
authors.lastname: Belyĭ
mesh_terms: D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D004198:Disease Susceptibility / Q000503:physiopathology; D004361:Drug Tolerance; D006801:Humans; D009294:Narcotics / Q000009:adverse effects / Q000494:pharmacology; D009293:Opioid-Related Disorders / Q000209:etiology* / Q000503:physiopathology; D015990:Placebo Effect; D012018:Reflex / Q000187:drug effects / Q000502:physiology; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology
chemical_list: D009294:Narcotics
vernacular_title: Uslovnoreflektornyĭ mekhanizm razvitiia tolerantnosti i zavisimosti ot narkoticheskikh sredstv.