In vivo binding of N1'-([11C]methyl)naltrindole to delta-opioid receptors in mouse brain.
The regional distribution of N1'-([11C]methyl)naltrindole ([11C]MeNTI) in vivo in mouse brain correlates with established delta opioid receptor densities in vitro. [11C]MeNTI binding is blocked by naltrindole, a delta antagonist, but not by cyprodime, a mu antagonist, of by (+/-)-U50,488, a kappa agonist. Thus, [11C]MeNTI selectively labels central delta opioid receptors in vivo in mouse, and shows promise for positron emission tomography studies of delta sites in human brain.
Lever
J R
JR
Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, MD 21205.
Scheffel
U
U
Kinter
C M
CM
Ravert
H T
HT
Dannals
R F
RF
Wagner
H N
HN
Frost
J J
JJ
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002250:Carbon Radioisotopes; D007211:Indoles / Q000378:metabolism*; D008297:Male; D051379:Mice; D009019:Morphinans / Q000378:metabolism*; D011869:Radioligand Assay; D017465:Receptors, Opioid, delta / Q000187:drug effects / Q000378:metabolism*; D014055:Tomography, Emission-Computed
D002250:Carbon Radioisotopes; D007211:Indoles; D009019:Morphinans; D017465:Receptors, Opioid, delta; C074392:N-methylnaltrindole