title: Synthesis, characterization and biodistribution of the cationic technetium(II) 1,10-phenanthroline chelate.
abstract: [99Tc(phen)3]Cl2 was synthesized by reduction of pertechnetate with sodium borohydride in the presence of an excess of 1,10-phenanthroline and characterized by FAB mass spectrometry, magnetic susceptibility measurements, and i.r./vis/u.v. spectrophotometry. For biodistribution evaluation in mice [99mTc(phen)3]Cl2 could be obtained in a radiochemical purity of 92.5% using a similar procedure. The rather hydrophilic chelate was predominantly excreted by the kidneys. Its low blood retention resulted in a heart/blood activity ratio of 4.2 at 100 min post-injection.
authors.affiliation: Institut für Chemie 1 (Nuklearchemie), Forschungszentrum Jülich GmbH (KFA), Germany.
authors.forename: K
authors.initials: K
authors.lastname: Schwochau
authors.forename: K H
authors.initials: KH
authors.lastname: Linse
authors.forename: Z F
authors.initials: ZF
authors.lastname: Su
mesh_terms: D000818:Animals; D051379:Mice; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D010618:Phenanthrolines / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014018:Tissue Distribution
chemical_list: D015609:Organotechnetium Compounds; D010618:Phenanthrolines; C078195:technetium Tc 99m 1,10-phenanthroline