Synthesis of no carrier added [1-11C]propenoic acid and derivatives.
The reproducible preparation of [1-11C]propenoic acid (acrylic acid) in 45-50% radiochemical yield was made possible by careful control of the temperature and time of the 11C carbonation of ethenylmagnesium bromide. It allowed the obtention of [1-11C]propenoyl chloride and N-[1-11C] substituted propenamides. These latter were highly reactive as it was shown by the obtention of a Michael adduct with secondary amines even at room temperature.
Lasne
M C
MC
Unité de Recherche Associée au CNRS D 0480, Institut des Sciences de la Matière et du Rayonnement, Caen, France.
Cairon
P
P
Barre
L
L
D000179:Acrylates / Q000138:chemical synthesis*; D000577:Amides / Q000138:chemical synthesis*; D002250:Carbon Radioisotopes; D007553:Isotope Labeling
D000179:Acrylates; D000577:Amides; D002250:Carbon Radioisotopes; C026200:acryloyl chloride; C036658:acrylic acid