Hypothalamic-pituitary-adrenal axis responsiveness to insulin-induced hypoglycaemia is modified by trypanosome infection in Boran (Bos indicus) cattle.
Ten Boran (Bos indicus) cattle were used to study the stress responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis during trypanosome infection. Five cattle were infected with Trypanosoma congolense IL 1180 by tsetse challenge and five cattle served as controls. All infected animals developed acute trypanosomiasis. Insulin-induced hypoglycaemia (50 per cent of pre-insulin glucose concentration) was used as a stress factor. Acute hypoglycaemia was observed in three infected and three control animals after insulin challenge. Two animals from each group either did not respond or responded slowly. Hypoglycaemia in infected animals completely failed to induce an HPA axis response, while in control animals an HPA axis response was indicated by a significant increase in plasma adrenocorticotrophic hormone (ACTH) and cortisol concentrations (P less than 0.01). The results show that trypanosomiasis in Boran cattle can cause a decrease in the stress responsiveness of the HPA axis as indicated by a blunted ACTH/cortisol response to insulin-induced hypoglycaemia.
Abebe
G
G
International Laboratory for Research on Animal Diseases, ILRAD, Nairobi, Kenya.
Eley
R M
RM
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D002417:Cattle; D006854:Hydrocortisone / Q000097:blood; D007003:Hypoglycemia / Q000139:chemically induced / Q000503:physiopathology / Q000662:veterinary; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D007328:Insulin; D010913:Pituitary-Adrenal System / Q000503:physiopathology*; D013312:Stress, Physiological / Q000503:physiopathology / Q000662:veterinary*; D014354:Trypanosomiasis, Bovine / Q000150:complications* / Q000503:physiopathology
D007328:Insulin; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone