title: The influence of age on susceptibility to motion sickness in monkeys.
abstract: A longitudinal study on the effects of age on the susceptibility to motion sickness in the squirrel monkey was carried out over a 10-year period (1982 to 1991). The typical life span of squirrel monkeys is 15 years. Ten mature male squirrel monkeys of the Bolivian subspecies were found to be susceptible to motion sickness induced by a combination of vertical oscillation at 0.5 Hz and rotation in the horizontal plane at 25 rotations per minute (RPM) in a visually unrestricted environment. Signs of motion sickness were quantified according to a rating scale based on Graybiel's diagnostic criteria. Latency to vomiting/retching and severity of sickness obtained from year 1 (baseline), 3, 5, 7 and 10 were subjected to repeated-measures design analysis. There were no significant differences in the susceptibility level (as measured by latency to vomiting/retching and cumulative sickness scores) in the monkeys throughout the 10-year period. The habituation to 7 consecutive daily exposures remained the same throughout the same period. We conclude that, in the squirrel monkeys from maturity to near the end of their life span, there is no change in susceptibility to motion sickness with aging.
authors.affiliation: Defence and Civil Institute of Environmental Medicine, Toronto, Ontario, Canada.
authors.forename: B S
authors.initials: BS
authors.lastname: Cheung
authors.forename: K E
authors.initials: KE
authors.lastname: Money
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D004198:Disease Susceptibility; D006185:Habituation, Psychophysiologic; D008137:Longitudinal Studies; D008297:Male; D009039:Motion Perception; D009041:Motion Sickness / Q000503:physiopathology*; D012453:Saimiri; D014724:Vestibular Function Tests; D014839:Vomiting / Q000503:physiopathology