[What have we learned from converting enzyme inhibitors on renin-angiotensin system?].
Angiotensin-converting-enzyme (ACE) inhibitors are now widely used to treat patients with high blood pressure or heart failure. The favourable results obtained with these inhibitors of the renin-angiotensin system suggest that angiotensin II has a noxious effect on the development and/or course of these diseases. ACE inhibitors are usually well tolerated. Their most severe side-effects are mostly foreseeable and therefore avoidable. Chronic blockade of the renin-angiotensin system increasingly seems to be a good therapeutic approach to the protection of the vital organs.
Waeber
B
B
Division d'hypertension, centre hospitalier universitaire Vaudois, Lausanne, Suisse.
Nussberger
J
J
Brunner
H R
HR
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D007703:Peptidyl-Dipeptidase A / Q000502:physiology*; D012084:Renin-Angiotensin System / Q000187:drug effects* / Q000502:physiology
D000806:Angiotensin-Converting Enzyme Inhibitors; D007703:Peptidyl-Dipeptidase A
Qu'est-ce que les inhibiteurs de l'enzyme de conversion nous ont appris sur le système rénine-angiotensine?