title: Effects of different dosages and modes of sodium bicarbonate administration during cardiopulmonary resuscitation.
abstract: Systemic acidosis occurs during cardiac arrest and cardiopulmonary resuscitation (CPR). The present study investigated the effect of different modes of sodium bicarbonate administration on blood gas parameters during CPR. Arterial and venous blood gases were obtained during 10 minutes of CPR which was preceded by 3 minutes of unassisted ventricular fibrillation in 36 dogs. Following 1 minute of CPR, the animals received one of four treatments in a randomized and blinded manner: normal saline (NS), sodium bicarbonate bolus dose 1 mEq/kg (B), sodium bicarbonate continuous infusion 0.1 mEq/kg/min (I), and sodium bicarbonate bolus dose (0.5 mEq/kg) plus continuous infusion 0.1 mEq/kg/min (L+I). Eleven dogs completed NS, 8 B, 8 I, and 9 L+I protocol. Following NS infusion, both arterial and venous pH declined consistently over time. Significant differences compared with NS treatment in venous pH were observed at 12 minutes of ventricular fibrillation (L+I, 7.27 +/- 0.05; NS, 7.15 +/- 0.05; B, 7.20 +/- 0.05; I, 7.24 +/- 0.04, each bicarbonate treatment versus NS, and L+I versus B, (P < .05). The B group had an elevated venous PCO2 (mm Hg) concentration following 6 minutes of ventricular fibrillation compared with NS, L+I, and I groups (81 +/- 14 versus 69 +/- 10 versus 68 +/- 10 versus 71 +/- 8, respectively, (P = .07). Arterial pH and PCO2 values showed a similar trend as the venous data with the L+I group demonstrating arterial alkalosis (pH > 7.45) at 12 minutes of ventricular fibrillation.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Pharmacy, Hartford Hospital, CT.
authors.forename: B E
authors.initials: BE
authors.lastname: Bleske
authors.forename: M S
authors.initials: MS
authors.lastname: Chow
authors.forename: H
authors.initials: H
authors.lastname: Zhao
authors.forename: J
authors.initials: J
authors.lastname: Kluger
authors.forename: A
authors.initials: A
authors.lastname: Fieldman
mesh_terms: D000138:Acidosis / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D000818:Animals; D001639:Bicarbonates / Q000008:administration & dosage*; D001769:Blood; D002245:Carbon Dioxide / Q000097:blood; D016887:Cardiopulmonary Resuscitation / Q000379:methods*; D004195:Disease Models, Animal; D004285:Dogs; D006323:Heart Arrest / Q000097:blood / Q000150:complications / Q000628:therapy*; D006863:Hydrogen-Ion Concentration; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D011897:Random Allocation; D012964:Sodium / Q000008:administration & dosage*; D017693:Sodium Bicarbonate; D012965:Sodium Chloride / Q000008:administration & dosage
chemical_list: D001639:Bicarbonates; D002245:Carbon Dioxide; D012965:Sodium Chloride; D017693:Sodium Bicarbonate; D012964:Sodium