title: Immuno-lectin histochemistry and ultrastructure in two cases of globoid cell leukodystrophy (Krabbe's disease).
abstract: Two cases of globoid cell leukodystrophy (Krabbe's disease) have been studied by means of conventional histological, immunohistochemical and ultrastructural methods. Lectins specific for several different carbohydrates, Ricinus communis (RCA-1), peanut agglutinin (PNA), wheat germ agglutinin (WGA) and Concanavalin A (Con A) have been utilized both at optical and ultrastructural level. In both cases a strong positive labeling of the globoid cells could be observed light-microscopically. Ultrastructurally immunogold deposits only of RCA-I and WGA in the typical Krabbe's inclusions have been clearly demonstrated.
authors.affiliation: Klinikum Steglitz, Freie Universität Berlin, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Figols
authors.forename: C
authors.initials: C
authors.lastname: Zimmer
authors.forename: R
authors.initials: R
authors.lastname: Warzok
authors.forename: J
authors.initials: J
authors.lastname: Cervos-Navarro
mesh_terms: D000116:Acetylgalactosamine / Q000032:analysis; D000117:Acetylglucosamine / Q000032:analysis; D001786:Blood Glucose / Q000032:analysis; D001921:Brain / Q000473:pathology*; D003593:Cytoplasm / Q000648:ultrastructure; D005690:Galactose / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D002479:Inclusion Bodies / Q000648:ultrastructure; D007223:Infant; D007965:Leukodystrophy, Globoid Cell / Q000235:genetics / Q000473:pathology*; D008297:Male; D008358:Mannose / Q000032:analysis; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000473:pathology; D019158:N-Acetylneuraminic Acid; D009474:Neurons / Q000473:pathology; D011975:Receptors, Mitogen / Q000032:analysis*; D012794:Sialic Acids / Q000032:analysis
chemical_list: D001786:Blood Glucose; D011975:Receptors, Mitogen; D012794:Sialic Acids; D019158:N-Acetylneuraminic Acid; D000116:Acetylgalactosamine; D008358:Mannose; D000117:Acetylglucosamine; D005690:Galactose