[Treatment of acute secretory diarrhea with casein: an effect of beta-casomorphins?].
A patient with acute secretory diarrhea refractory to conventional therapy received calcium caseinate as sole nutrient, based on the recognized development of constipation and fecaloma in patients receiving this agent. Complete remission of diarrhea followed within 10 days. An inhibition of intestinal motility mediated by B-casomorphins released after hydrolysis of casein in the intestinal tract may be the mechanism involved in this effect. These exorphins have varying effects upon the opioid receptors of the intestinal tract.
Charlin
V
V
Departamento de Nutrición, Facultad de Medicina, Universidad de Chile, Hospital Clínico José Joaquín Aguirre, Santiago.
Defilippi
C
C
Vargas
V
V
Borghesi
L
L
Gómez
E
E
D000208:Acute Disease; D000368:Aged; D002364:Caseins / Q000494:pharmacology / Q000627:therapeutic use*; D003967:Diarrhea / Q000188:drug therapy*; D004723:Endorphins / Q000494:pharmacology*; D006801:Humans; D008297:Male
D002364:Caseins; D004723:Endorphins; C021968:beta-casomorphins
Tratamiento con caseína en diarrea secretora aguda: una acción de las beta-casomorfinas?