Do we know the site of action of cyclosporin?
The site and mode of action of cyclosporin A (CsA) have been subjects of study ever since CsA was discovered and demonstrated to be a selective suppressor of allograft rejection. In this article, Bernard Erlanger traces progress to date and presents evidence that the site of action is not cytoplasmic cyclophilin but a lymphocyte cell-surface receptor that might be related in structure to cyclophilin.
Erlanger
B F
BF
Dept of Microbiology, Columbia University Health Sciences Center, New York, NY 10032.
D000591:Amino Acid Isomerases / Q000502:physiology*; D000818:Animals; D019703:Calcineurin; D002148:Calmodulin-Binding Proteins / Q000502:physiology; D002352:Carrier Proteins / Q000502:physiology*; D002462:Cell Membrane / Q000502:physiology; D016572:Cyclosporine / Q000494:pharmacology*; D003593:Cytoplasm / Q000502:physiology; D006801:Humans; D007165:Immunosuppression Therapy; D019696:Peptidylprolyl Isomerase; D010749:Phosphoprotein Phosphatases / Q000502:physiology
D002148:Calmodulin-Binding Proteins; D002352:Carrier Proteins; D016572:Cyclosporine; D019703:Calcineurin; D010749:Phosphoprotein Phosphatases; D000591:Amino Acid Isomerases; D019696:Peptidylprolyl Isomerase