Tibial osteomyelitis due to Aspergillus flavus in a heart transplant patient.
Aspergillus flavus was identified as the causative organism of a case of osteomyelitis involving the proximal epiphysis of the left tibia in a heart transplant patient. History revealed a previous pretibial wound due to a fall in the street as the consequence of a sudden cardiac arrest. Surgical debridement combined with fungostatic treatment including amphotericin B and itraconazole was followed by clinical improvement, although the fungus could still be recovered by culture on subsequent samples.
De Vuyst
D
D
Dept. of Bacteriology, University Hospitals, Leuven, Belgium.
Surmont
I
I
Verhaegen
J
J
Vanhaecke
J
J
D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy / Q000382:microbiology; D001231:Aspergillus flavus / Q000302:isolation & purification; D003646:Debridement; D016027:Heart Transplantation; D006801:Humans; D016867:Immunocompromised Host; D017964:Itraconazole; D007654:Ketoconazole / Q000031:analogs & derivatives / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000188:drug therapy / Q000382:microbiology*; D013977:Tibia / Q000382:microbiology*
D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B; D007654:Ketoconazole