[Role of local peptide regulators in the maturation of ovarian follicles].
Follicular maturation and ovulation are triggered by pituitary hormones, specifically, follicle stimulating hormone (FSH) and luteinizing hormone (LH). Nevertheless ovarian response to gonadotropins is systematic and not targeted. Adequate physiological response, i.e. maturation of a single dominant follicle and a single ovulation, is dependent on local modulation of the response by local paracrine and autocrine regulators. Presently, we may conclude TGF alpha and IGF-I and II are implied in growth of cellular components of the follicles: granulosa and theca cells. TGF beta and activins stimulate cellular differentiation with production of estrogens and inhibins. TGF alpha is the single local factor which accelerates the meiotic competence acquisition. Finally, follistatin seems to be a powerful atretic factor for cohort follicles and luteinizing agent for dominant follicle.
Franchimont
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D028341:Activins; D002454:Cell Differentiation / Q000187:drug effects; D005260:Female; D038681:Follistatin; D006023:Glycoproteins / Q000494:pharmacology; D006107:Granulosa Cells / Q000187:drug effects* / Q000502:physiology; D006133:Growth Substances / Q000494:pharmacology*; D006801:Humans; D007265:Inhibins / Q000494:pharmacology; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology; D007335:Insulin-Like Growth Factor II / Q000494:pharmacology; D013799:Theca Cells / Q000187:drug effects* / Q000502:physiology; D016211:Transforming Growth Factor alpha / Q000494:pharmacology
D038681:Follistatin; D006023:Glycoproteins; D006133:Growth Substances; D016211:Transforming Growth Factor alpha; D028341:Activins; D007265:Inhibins; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II
Le rôle des régulateurs peptidiques locaux dans la maturation des follicules ovariens.