[The effect of different body allowances of aldosterone on serotonin and cAMP metabolism in the tissues of rats with a disordered trophic function of the nervous system].
Effect of aldosterone on the content of serotonin, cAMP, and the activity of 5-hydroxytryptophane decarboxylase was studied in different rat tissues (hypothalamus, kidneys, tibial muscles) in norm and following the lesion of sciatic nerve in nonadrenalectomized and adrenalectomized animals, that is in conditions of severe deficiency of endogenous aldosterone. In nonadrenalectomized rats, exogenous aldosterone exerted either very little effect or no effect on the tissues metabolism of serotonin and cAMP. Aldosterone induced changes in the content of considered substances against the background of adrenalectomy in animals with intact sciatic nerve. These changes were observed usually only in hypothalamus and kidneys and reached their peak 60 or 90 min following the aldosterone administration. The changes in serotonin and cAMP tissues metabolism under the chronic stimulation of nervous system periphery with aldosterone may be an additional factor which enables further aggravation of trophic state of tissues and organs and alteration of their sensitivity to hormones, in particular, aldosterone.
Azhipa
Ia I
IaI
Egorova
L K
LK
D000315:Adrenalectomy; D000450:Aldosterone / Q000494:pharmacology*; D000818:Animals; D001142:Aromatic-L-Amino-Acid Decarboxylases / Q000187:drug effects / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism*; D008297:Male; D009422:Nervous System Diseases / Q000378:metabolism*; D051381:Rats; D012584:Sciatic Nerve / Q000293:injuries / Q000502:physiology; D012701:Serotonin / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution / Q000187:drug effects
D012701:Serotonin; D000450:Aldosterone; D000242:Cyclic AMP; D001142:Aromatic-L-Amino-Acid Decarboxylases
Vliianie raznoĭ obespechenosti organizma alsoteronom na obmen serotonina i tsAMF v tkaniakh krys pri narushenii troficheskoĭ funktsii nervnoĭ sistemy.