title: Retinal periphlebitis in patients with acquired immunodeficiency syndrome with cytomegalovirus retinitis mimics acute frosted retinal periphlebitis.
abstract: Acute frosted retinal periphlebitis is an inflammatory condition of unknown origin characterized by marked perivenular infiltration in otherwise healthy patients. We encountered seven patients with acquired immunodeficiency syndrome who exhibited visual loss associated with an unusual diffuse retinal periphlebitis very similar in appearance to acute frosted retinal periphlebitis. Each patient developed a thick inflammatory infiltrate surrounding the retinal venules, creating a frosted appearance. Two cases were bilateral. All patients had areas of more typical cytomegalovirus retinitis in their involved eye(s). Five of six patients treated with ganciclovir sodium showed improvement not only of the cytomegalovirus retinitis but also of the periphlebitis. Although we do not have histopathologic evidence that cytomegalovirus was the cause of these cases of periphlebitis, we believe that periphlebitis may be a previously unrecognized finding of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome. So far, there is no evidence implicating cytomegalovirus as the cause of acute frosted retinal periphlebitis in healthy patients.
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago.
authors.forename: M F
authors.initials: MF
authors.lastname: Rabb
authors.forename: L M
authors.initials: LM
authors.lastname: Jampol
authors.forename: R H
authors.initials: RH
authors.lastname: Fish
authors.forename: R V
authors.initials: RV
authors.lastname: Campo
authors.forename: W M
authors.initials: WM
authors.lastname: Sobol
authors.forename: N M
authors.initials: NM
authors.lastname: Becker
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D003586:Cytomegalovirus Infections / Q000175:diagnosis*; D015828:Eye Infections, Viral / Q000175:diagnosis*; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D015658:HIV Infections / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D010689:Phlebitis / Q000175:diagnosis*; D012164:Retinal Diseases / Q000175:diagnosis*; D012173:Retinitis / Q000175:diagnosis* / Q000382:microbiology; D014792:Visual Acuity