Intragenic suppression: Stalker, a retrovirus-like transposable element, can compensate for a deficiency at the cut locus of Drosophila melanogaster.
A number of mutations at the cut locus were induced by non-precise excision of a silent P-element insertion which resulted in deletions at the regulatory region of the locus. Unexpectedly, a reversion of one of these mutations was found, which appears as a result of insertion of Stalker (a retrovirus-like mobile element) near the 1.3 kb deletion. Thus an insertion of a retrovirus-like mobile element can suppress the deficiency at the regulatory region of a gene.
Mogila
V A
VA
Institute of Gene Biology, Academy of Sciences of the USSR, Moscow, Russia.
Ladvishenko
A B
AB
Simonova
O B
OB
Gerasimova
T I
TI
D000818:Animals; D003433:Crosses, Genetic; D004252:DNA Mutational Analysis; D004251:DNA Transposable Elements / Q000235:genetics; D003673:Defective Viruses / Q000235:genetics*; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D018398:Homeodomain Proteins; D017403:In Situ Hybridization; D008297:Male; D016254:Mutagenesis, Insertional; D009419:Nerve Tissue Proteins / Q000172:deficiency / Q000235:genetics*; D009687:Nuclear Proteins / Q000172:deficiency / Q000235:genetics*; D012045:Regulatory Sequences, Nucleic Acid; D012190:Retroviridae / Q000235:genetics*; D013489:Suppression, Genetic; D014157:Transcription Factors
D004251:DNA Transposable Elements; D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors; C066381:ct protein, Drosophila