title: [Myocardial beta-adrenergic receptors and left ventricular hypertrophy induced by pressure overload in man].
abstract: In experimental models, the characteristics of beta-adrenoceptors in left ventricular hypertrophy (LVH) due to pressure overload remain controversial and no data are still available in man. We investigated right auricular (RA) and left ventricular (LV) beta-adrenoceptors characteristics (125 I cyanopindolol binding) in two groups of patients undergoing valve replacement without heart failure (LV ejection fraction > 55%). Height patients with mitral stenosis (mean age: 64 +/- 4 years) and without LVH (LV mass index < 120 g/m2) constituted the control group and 13 patients with aortic stenosis (mean age: 66 +/- 4 years) and LVH (LV mass index > 150 g/m2) the study group. The results are: [table: see text] These results show that, in man, LVH due to pressure overload does not induce variation of total number beta-adrenoceptors, but is associated with a selective decrease in left ventricular beta 1-adrenoceptors.
authors.affiliation: Laboratoire de pharmacologie médicale et clinique, INSERM U317, faculté de médecine, Toulouse.
authors.forename: M
authors.initials: M
authors.lastname: Galinier
authors.forename: J M
authors.initials: JM
authors.lastname: Sénard
authors.forename: G
authors.initials: G
authors.lastname: Dréan
authors.forename: P
authors.initials: P
authors.lastname: Valet
authors.forename: Y
authors.initials: Y
authors.lastname: Glock
authors.forename: P
authors.initials: P
authors.lastname: Dalous
authors.forename: D
authors.initials: D
authors.lastname: Roux
authors.forename: J
authors.initials: J
authors.lastname: Puel
authors.forename: J L
authors.initials: JL
authors.lastname: Montastruc
authors.forename: J P
authors.initials: JP
authors.lastname: Bounhoure
mesh_terms: D000368:Aged; D002395:Catecholamines / Q000097:blood; D015536:Down-Regulation; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000032:analysis*; D013564:Sympathetic Nervous System / Q000503:physiopathology
chemical_list: D002395:Catecholamines; D011943:Receptors, Adrenergic, beta
vernacular_title: Récepteurs bêta-adrénergiques myocardiques et hypertrophie ventriculaire gauche induite par une surcharge barométrique chez l'homme.