[Immunological effects of live attenuated hepatitis A vaccine].
11,451 health persons were inoculated with live attenuated hepatitis A vaccine (H2 strain) in 3 batches. Among them, 785 were tested for anti-HAV antibody response by ELISA. The results showed that H2-strain vaccine got a quick antibody response (2-5 weeks) and a high seroconversion rate (92.9%). Also, the titers of antibodies to HAV ranged from 1:2 to 1:32. The seroconversion of the first 12 recipients lasted for 3 years. The primary epidemiological studies demonstrated that H2-strain vaccine was effective in preventing hepatitis A. The relation between the positive rate of antibody and different dosage showed that 10(6.5)TCID50 could get a highest seroconversion rate (100%).
Cheng
N L
NL
Zhejiang Academy of Medical Sciences, Hangzhou.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006506:Hepatitis A / Q000517:prevention & control*; D006508:Hepatitis Antibodies / Q000097:blood*; D006507:Hepatovirus / Q000276:immunology*; D006801:Humans; D008297:Male; D014613:Vaccines, Attenuated / Q000276:immunology; D014761:Viral Hepatitis Vaccines / Q000276:immunology*
D006508:Hepatitis Antibodies; D014613:Vaccines, Attenuated; D014761:Viral Hepatitis Vaccines