Attenuation by the benzodiazepine receptor antagonist, ZK 93 426, of the deficit in spatial navigation induced by nucleus basalis lesions.
The effects of the benzodiazepine receptor antagonist, beta-carboline ZK 93,426 treatment were studied both in NB-lesioned (ibotenic acid) and in unoperated Kuo-Wistar rats in a water maze task. The ZK 93,426 administered in the doses of 1 and 5 mg/kg, 30 min prior to the testing in a water maze apparatus, attenuated the NB lesion-induced spatial navigation deficit, although it had no effect on the performance of unoperated rats. The results suggest functional interactions between GABAergic system and ibotenic acid-induced lesion of the basal forebrain in rats.
Mazurkiewicz
M
M
Department of Neurology, University of Kuopio, Finland.
Sirviö
J
J
Riekkinen
P
P
D000704:Analysis of Variance; D000818:Animals; D002243:Carbolines / Q000494:pharmacology*; D002795:Choline O-Acetyltransferase / Q000032:analysis; D058787:GABA-A Receptor Antagonists; D008297:Male; D011597:Psychomotor Performance / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000502:physiology*; D013028:Space Perception / Q000187:drug effects* / Q000502:physiology; D013377:Substantia Innominata / Q000502:physiology*
D002243:Carbolines; D058787:GABA-A Receptor Antagonists; D011963:Receptors, GABA-A; C042568:ZK 93426; D002795:Choline O-Acetyltransferase