title: Inhibition of ingestive behavior following fourth ventricle bombesin injection in chronic decerebrate rats.
abstract: To test the hypothesis that the effects of 4th ventricle bombesin (BN) injection on feeding require interaction with forebrain neural systems, intraoral sucrose (0.1 M) was measured in tube-fed control and tube-fed supracollicular decerebrate rats after 4th ventricle injections of 1, 5, 10, 20, and 50 ng BN. Fourth ventricle injections of all doses of BN reliably suppressed sucrose intake in both control and chronic decerebrate rats. These results indicate that caudal brain stem afferent signals produced by 4th ventricle BN injections are integrated by the local neural circuitry of the caudal brain stem, independent of the forebrain systems, to modulate ingestive behavior.
authors.affiliation: Department of Psychology, University of Wyoming, Laramie 82071.
authors.forename: F W
authors.initials: FW
authors.lastname: Flynn
authors.forename: L
authors.initials: L
authors.lastname: Robillard
mesh_terms: D000818:Animals; D001839:Bombesin / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects*; D001931:Brain Mapping; D001933:Brain Stem / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects; D003655:Decerebrate State; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D018004:Receptors, Bombesin; D017981:Receptors, Neurotransmitter / Q000187:drug effects; D013395:Sucrose; D013649:Taste / Q000187:drug effects*
chemical_list: D018004:Receptors, Bombesin; D017981:Receptors, Neurotransmitter; D013395:Sucrose; D001839:Bombesin