Binding of strychnocarpine and related beta-carbolines to brain receptors in vitro.
The affinity of strychnocarpine and related beta-carbolines for serotonin, benzodiazepine, tryptamine, opiate and GABA receptors in rat brain was studied. Strychnocarpine showed a low to very low affinity for all the receptors tested. The weak binding to tryptamine receptors might explain part of the tremorigenic effects found earlier in the in vivo studies.
Strömbom
J
J
Department of Pharmacognosy, University of Uppsala, Sweden.
Jokela
R
R
Saano
V
V
Rolfsen
W
W
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002243:Carbolines / Q000737:chemistry / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011963:Receptors, GABA-A / Q000378:metabolism; D011985:Receptors, Serotonin / Q000378:metabolism
D002243:Carbolines; D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D011985:Receptors, Serotonin; C029066:strychnocarpine