[Fatty acid compositions of cholesteryl esters. Different species and their correlation with susceptibility to atherosclerosis].
Fatty acid compositions of serum cholesteryl esters (CE) in human and animals were analysed. Polyunsaturated fatty acids (PUFA) were the predominant fatty acids in CE. A close relation between PUFA to saturated fatty acids (P/S) ratio in CE and susceptibility to atherosclerosis (AS) was observed among different species. Animals with high P/S such as tree shrews and rats (P/S 9.0) were AS-resistant, and those with low P/S such as rabbits (P/S 2.9) were susceptible to AS. The P/S ratio in human serum CE (4.9) was between those in the above two kinds of animals, and similar to those in pigs (4.2) and monkeys (3.7). A great physiological significance of abundant PUFA in CE could be expected. As the main part of low density lipoprotein (LDL), CE might provide PUFA to cells efficiently via LDL receptor. It was assumed that PUFA in CE were closely correlated with the metabolism of cholesterol and the development of AS by regulating LDL receptor activity, platelet function and prostaglandin synthesis, all of which would be affected by PUFA in cells.
Chen
W
W
Beijing Institute of Geriatrics.
D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology*; D002645:Chickens; D002788:Cholesterol Esters / Q000737:chemistry*; D004198:Disease Susceptibility; D004285:Dogs; D005227:Fatty Acids / Q000032:analysis*; D005231:Fatty Acids, Unsaturated / Q000032:analysis*; D005260:Female; D006801:Humans; D008253:Macaca mulatta; D008297:Male; D051379:Mice; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity; D013552:Swine; D014418:Tupaiidae
D002788:Cholesterol Esters; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated