Immunohistochemical identification of transforming growth factor-beta and its binding protein in human gastrointestinal carcinoma.
We attempted to clarify the tissue localization of TGF-beta and latent TGF-beta binding protein (LTBP) in human gastrointestinal carcinomas by immunohistochemistry. The immunoreactivity for TGF-beta was observed in both carcinoma cells and stromal cells, particularly in diffuse-type gastric carcinoma. The immunoreactivity for LTBP was observed only in stromal cells. These results suggest that both carcinoma cells and stromal cells may produce TGF-beta, and that only stromal cells may produce LTBP in gastrointestinal carcinoma.
Mizoi
T
T
Department of Pathology and Surgery, Tohoku University School of Medicine, Sendai, Japan.
Ohtani
H
H
Matsuno
S
S
Nagura
H
H
D005770:Gastrointestinal Neoplasms / Q000737:chemistry*; D006801:Humans; D007150:Immunohistochemistry; D011956:Receptors, Cell Surface / Q000032:analysis*; D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta / Q000032:analysis*
D011956:Receptors, Cell Surface; D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta