Effects in vitro of two marine substances, chlorolissoclimide and dichlorolissoclimide, on a non-small-cell bronchopulmonary carcinoma line (NSCLC-N6).
The antiproliferative activity of two nitrogenous labdane cytotoxic substances from Lissoclinum voeltzkowi Michaelson (Urochordata), dichlorolissoclimide (P2) and chlorolissoclimide (P1), was studied in vitro on a continuous human non-small-cell bronchopulmonary carcinoma line (NSCLC-N6) at the cell cycle level. This antiproliferative effect resulted from a blockade of G1 phase cells. Mortality occurred, regardless of the degree of cell ploidy, with cell transition to an out-of-cycle situation characteristic of a G1D terminal maturation state.
Malochet-Grivois
C
C
Substances Marines à Activités Biologiques, faculté de Pharmacie, Nantes, France.
Roussakis
C
C
Robillard
N
N
Biard
J F
JF
Riou
D
D
Débitus
C
C
Verbist
J F
JF
D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000473:pathology; D004224:Diterpenes / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005434:Flow Cytometry; D016193:G1 Phase / Q000187:drug effects; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013388:Succinimides / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D004224:Diterpenes; D013388:Succinimides; C079664:dichlorolissoclimide; C079665:chlorolissoclimide