title: Hemorrhagic cystitis with herpes simplex virus type 2 in the bladder mucosa.
abstract: A 67-year-old woman who had underlying rheumatoid arthritis and diabetes mellitus had an 8-year history of recurrent hemorrhagic cystitis. During her most recent episode of cystitis, a specimen of urine yielded herpes simplex virus type 2 in culture. A biopsy of the bladder mucosa revealed intranuclear inclusions in multinucleated and mononuclear giant cells that were positive for herpes simplex virus type 2 by immunoperoxidase staining. She had no evidence of infection with herpes simplex virus outside her bladder.
authors.affiliation: Department of Medicine, Montefiore University Hospital, Pittsburgh, Pennsylvania 15213.
authors.forename: M L
authors.initials: ML
authors.lastname: Nguyen
authors.forename: D
authors.initials: D
authors.lastname: Borochovitz
authors.forename: G
authors.initials: G
authors.lastname: Thomas
authors.forename: T
authors.initials: T
authors.lastname: McClure
authors.forename: F L
authors.initials: FL
authors.lastname: Ruben
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications; D003556:Cystitis / Q000150:complications / Q000382:microbiology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D005260:Female; D006470:Hemorrhage / Q000150:complications / Q000382:microbiology*; D006561:Herpes Simplex / Q000150:complications / Q000382:microbiology*; D006801:Humans; D009092:Mucous Membrane / Q000382:microbiology / Q000473:pathology; D012008:Recurrence; D018139:Simplexvirus / Q000302:isolation & purification*; D001743:Urinary Bladder / Q000382:microbiology* / Q000473:pathology