title: Cyclic adenosine 3',5'-monophosphate content and bronchial smooth muscle contractility of hyper- and hypothyroid lungs.
abstract: 1. Male Sprague-Dawley rats were made either hyper- or hypothyroid with thyroxine or 4-methyl-2-thiouracil, respectively. Bronchial smooth muscle (BSM) contractility and lung cyclic adenosine 3',5'-monophosphate (cAMP) content were measured in both conditions. 2. Bronchial smooth muscle contractility was significantly weaker in hyperthyroid rats, while the BSM contractility of hypothyroid rats was the same as controls. 3. The cAMP content of hyperthyroid rat lungs was similar to controls but was decreased in hypothyroid rats. 4. These studies demonstrated that both the hyper- and hypothyroid states affect respiration, although the mechanisms involved with different for each condition.
authors.affiliation: Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur.
authors.forename: B M
authors.initials: BM
authors.lastname: Nabishah
authors.forename: P B
authors.initials: PB
authors.lastname: Morat
authors.forename: A K
authors.initials: AK
authors.lastname: Alias
authors.forename: B A
authors.initials: BA
authors.lastname: Kadir
authors.forename: B A
authors.initials: BA
authors.lastname: Khalid
mesh_terms: D000818:Animals; D001980:Bronchi / Q000502:physiology*; D000242:Cyclic AMP / Q000032:analysis*; D006980:Hyperthyroidism / Q000503:physiopathology*; D007037:Hypothyroidism / Q000503:physiopathology*; D008168:Lung / Q000737:chemistry*; D008297:Male; D008779:Methylthiouracil / Q000494:pharmacology; D009119:Muscle Contraction / Q000502:physiology; D009130:Muscle, Smooth / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013974:Thyroxine / Q000494:pharmacology
chemical_list: D000242:Cyclic AMP; D013974:Thyroxine; D008779:Methylthiouracil