[The significance of the mu- and delta-opiate receptors in realizing enkephalin action on the course of hypoxic hypoxia].
New enkephalins analogues have been synthesized. They are characterized by linear, cyclic and branched peptide chain. A relationship has been established between antihypoxic activity of opioid peptides an their interaction with opiate receptors. Compounds efficiently interacting with mu-receptors irrespective of delta-receptors affinity, promote longer survival of mice in hypoxia. The antihypoxic effect of opioids is proportional to their specificity to mu-receptors.
Zoloev
G K
GK
Argintaev
E S
ES
Bobrova
I V
IV
Shil'nikov
M G
MG
Pavlenko
V S
VS
Abisova
N A
NA
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004745:Enkephalins / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D006168:Guinea Pigs; D000860:Hypoxia / Q000188:drug therapy* / Q000401:mortality; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011957:Receptors, Opioid / Q000187:drug effects*; D013329:Structure-Activity Relationship
D004745:Enkephalins; D011957:Receptors, Opioid
Znachenie miu- i del'ta-opiatnykh retseptorov v realizatsii deĭstviia énkefalinov na techenie gipoksicheskoĭ gipoksii.