title: [The receptor binding of 3H-corticosterone by rat hepatocytes].
abstract: The binding of 3H-corticosterone was studied on rat hepatocytes both in presence of unlabeled corticosterone, obsidan and their absence at 0 degrees-4 degrees C. The analysis of binding by the method of Scatchard showed that there are two types of specific binding sites for 3H-corticosterone. Possible existence of proper glucocorticoid receptors (Ka = 4 x 10(9)M-1, n = 0.52 x 10(-14) mol/mg prot.) has been shown, as well as possibility of 3H-corticosterone interaction with beta-adrenoreceptors (Ka = 1.2 x 10(9)M-1, n = 0.9 x 10(-14) mol/mg prot.) have been demonstrated on hepatocytes.
authors.forename: L E
authors.initials: LE
authors.lastname: Panin
authors.forename: O M
authors.initials: OM
authors.lastname: Trubitsyna
authors.forename: T A
authors.initials: TA
authors.lastname: Tret'iakova
authors.forename: I F
authors.initials: IF
authors.lastname: Usynin
mesh_terms: D000818:Animals; D002469:Cell Separation / Q000379:methods; D002478:Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D003345:Corticosterone / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000378:metabolism; D011965:Receptors, Glucocorticoid / Q000187:drug effects / Q000378:metabolism*; D011987:Receptors, Steroid; D014316:Tritium
chemical_list: D011943:Receptors, Adrenergic, beta; D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; C024357:corticosterone receptor; D014316:Tritium; D011433:Propranolol; D003345:Corticosterone
vernacular_title: Retseptsiia 3H-kortikosterona gepatotsitami kryus.