IgG paraproteins in neurological diseases: lack of association with neurotropic viral/bacterial antigens.
In this study we tested the hypothesis that IgG paraproteins in neurological diseases might be regarded as an anti-idiotypic response raised by a nervous system antigen associated with certain neurotropic agents. After initial ELISA screen, positive samples from 34 neurological patients who had paraproteins in their CSF and serum on routine IEF investigation, were tested by immunoblot technique for the presence of specific monoclonal immunoglobulin G (IgG) against eight different neurotropic antigens. Only one patient had specific monoclonal IgG against herpes simplex virus. The results of this study did not confirm our hypothesis. Further study of IgM/IgA paraproteins is indicated.
Mavra
M
M
Institute of Neurology, National Hospital, London, England.
Luxton
R
R
Thompson
E J
EJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000942:Antigens, Bacterial / Q000134:cerebrospinal fluid*; D000956:Antigens, Viral / Q000134:cerebrospinal fluid*; D003587:Cytomegalovirus / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D014645:Herpesvirus 3, Human / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000175:diagnosis / Q000276:immunology*; D009460:Neurologic Examination; D010266:Paraproteins / Q000134:cerebrospinal fluid*; D018139:Simplexvirus / Q000276:immunology
D000942:Antigens, Bacterial; D000956:Antigens, Viral; D007074:Immunoglobulin G; D010266:Paraproteins