Aluminum(III) facilitates the oxidation of NADH by the superoxide anion.
Al(III) augments the oxidation of reduced nicotinamide adenine dinucleotide (NADH) by enzymatic or photochemical sources of O2-. Superoxide dismutase, but not catalase, inhibited this action of Al(III). It thus appears that Al(III) forms a complex with O2-, which is a stronger oxidant than is O2- itself and which may contribute to the adverse biological effects of Al(III).
Kong
S
S
Duke University Medical Center, Durham, NC 27710.
Liochev
S
S
Fridovich
I
I
D000535:Aluminum / Q000737:chemistry*; D005609:Free Radicals; D066298:In Vitro Techniques; D009243:NAD / Q000737:chemistry*; D010084:Oxidation-Reduction; D010777:Photochemistry; D013482:Superoxide Dismutase / Q000737:chemistry; D013481:Superoxides / Q000737:chemistry*; D014969:Xanthine Oxidase / Q000737:chemistry
D005609:Free Radicals; D009243:NAD; D013481:Superoxides; D000535:Aluminum; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase