[Changes in T cell subsets and the expression of receptors of transferrin and interleukin-2 in chronic active hepatitis].
The changes of T-cell subsets and expression of transferrin receptor (TFR) and interleukin-2 receptor (IL 2 R) of peripheral blood lymphocyte from patients with chronic active hepatitis (ACH) and chronic serious hepatitis (CSH) were studied. The results showed that T3+ cells were decreased. (P less than 0.01) and T8+ cells were significantly increased (P less than 0.01) in patients with CAH and CSH. TH/TS ratio was markedly decreased in both groups of patients (P less than 0.01). The data also showed that TFR and IL 2 R were in a state of high-expression in resting T-cell, but no obvious changes could be found in the expression of receptor of PHA-stimulated T cells of patients, as compared the controls. The results suggested that some inhibitory factor may be present in the serum of CAH and CSH patients.
Tang
W
W
Institut of Liver Disease, Tongji Medical University, Wuhan.
D016516:CD4-CD8 Ratio; D006509:Hepatitis B / Q000276:immunology* / Q000378:metabolism; D006521:Hepatitis, Chronic / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D011990:Receptors, Transferrin / Q000032:analysis*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D015375:Receptors, Interleukin-2; D011990:Receptors, Transferrin