Regulation of rat renal (Na(+) + K+)-adenosine triphosphatase mRNA levels by corticosterone.
We investigated the mechanisms for glucocorticoid regulation of rat renal NaK-ATPase activity. Our findings suggest that the magnitudes of corticosterone-induced increases in alpha 1 mRNA and beta 1 mRNA levels are similar in the kidney of the adult adrenalectomized rats. The results also suggest that corticosterone restores NaK-ATPase activity in adrenalectomized rats prior to any enhanced sodium delivery.
Klein
L E
LE
Department of Physiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814.
Lo
C S
CS
D000315:Adrenalectomy; D000818:Animals; D003345:Corticosterone / Q000494:pharmacology*; D015870:Gene Expression / Q000187:drug effects; D007668:Kidney / Q000502:physiology*; D007672:Kidney Cortex / Q000201:enzymology; D007679:Kidney Medulla / Q000201:enzymology; D008297:Male; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000235:genetics* / Q000378:metabolism
D012333:RNA, Messenger; D000254:Sodium-Potassium-Exchanging ATPase; D003345:Corticosterone