title: Treatment of carcinoma in situ of the cervix experience at the Faculty of Medicine, University of São Paulo.
abstract: The authors studied a total of 334 cases of carcinoma in situ of the cervix (1975-1990). The patients were 19 to 61 years old (mean age, 36.6 years). The following procedures were performed: cervical amputation in 54.5% of cases, cervical enlarged amputation with resection of the adjacent vaginal mucosa in 23.3%, abdominal hysterectomy in 15.3%, electrocauterization in 3.6%, simple conization in 2.4%, and vaginal hysterectomy in 0.9%. Recurrence rates were: 9.8% after cervical amputation, 1.3% after cervical enlarged amputation, 25% after simple conization, 5.8% after abdominal hysterectomy, and 33% after electrocauterization. Recurrences were detected before the 18th month after treatment and none of them was of the invasive type. The treatment procedure with the highest rate of complications was cervical enlarged amputation (16%), followed by simple conization (12%), total abdominal hysterectomy (3.9%), and cervical amputation (2.9%). The authors conclude that, although cervical enlarged amputation was followed by the lowest recurrence rate, it was also the treatment followed by the largest number of complications. On this basis, they recommend cervical amputation or hysterectomy. For young women who wish to have children, simple conization is recommended.
authors.affiliation: Faculdade de Medicina, University of São Paulo, Brasil.
authors.forename: J S
authors.initials: JS
authors.lastname: Souen
authors.forename: J P
authors.initials: JP
authors.lastname: Carvalho
authors.forename: J R
authors.initials: JR
authors.lastname: Filassi
authors.forename: J A
authors.initials: JA
authors.lastname: Marques
authors.forename: A
authors.initials: A
authors.lastname: Ades
authors.forename: J A
authors.initials: JA
authors.lastname: Pinotti
mesh_terms: D000328:Adult; D001938:Brazil / Q000453:epidemiology; D002278:Carcinoma in Situ / Q000453:epidemiology / Q000601:surgery*; D002584:Cervix Uteri / Q000601:surgery; D005260:Female; D006785:Hospitals, University / Q000706:statistics & numerical data; D006801:Humans; D007044:Hysterectomy / Q000379:methods / Q000706:statistics & numerical data; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D013997:Time Factors; D017211:Treatment Failure; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000601:surgery*