Recurrent genital infection in the guinea pig: differences between herpes simplex types 1 and 2.
Recurrence rates of genital infections are significantly higher for herpes simplex virus (HSV) type 2 than HSV type 1. Reasons for this difference are not known. In this report, multiple strains of HSV-1 and HSV-2 were evaluated in the guinea-pig model. HSV-2 strains showed significantly higher genital lesion recurrence than HSV-1, including HSV-1 McKrae strain which is highly recurrent in ocular infections. HSV-2 strains were also associated with more frequent asymptomatic vaginal virus shedding. Further study showed that HSV-1 strains replicated as well as HSV-2 in both the genital tract and the nervous system during acute infection. In addition, no difference was detected between HSV-1 and HSV-2 in nervous system latency. Thus, a number of possible explanations for the observed difference in genital herpes recurrence rates were examined and excluded.
Landry
M L
ML
Virology Reference Laboratory/151B, VA Medical Center, West Haven, CT 06516.
Myerson
D
D
Bull
C
C
D000208:Acute Disease; D000818:Animals; D005260:Female; D014644:Genetic Variation; D006168:Guinea Pigs; D006558:Herpes Genitalis / Q000150:complications / Q000382:microbiology* / Q000401:mortality; D009422:Nervous System Diseases / Q000150:complications / Q000382:microbiology; D012008:Recurrence; D018139:Simplexvirus / Q000235:genetics* / Q000254:growth & development; D017201:Virus Shedding