title: T1 and T2 of ferritin at different field strengths: effect on MRI.
abstract: Nuclear magnetic relaxation times T1 and T2 were measured in ferritin solutions at field strengths from 0.04 to 1.5 T. T1 was relatively constant, but 1/T2 increased linearly with field strength, in agreement with earlier MRI observations in the monkey brain. This finding supports the theory that ferritin is responsible for T2 shortening in brain nuclei containing iron. The linear dependence of 1/T2 on magnetic field is unique and not explained by present theories of the magnetic properties of ferritin.
authors.affiliation: Neuroimaging Branch, NINDS, National Institutes of Health, Bethesda, Maryland 20892.
authors.forename: J
authors.initials: J
authors.lastname: Vymazal
authors.forename: R A
authors.initials: RA
authors.lastname: Brooks
authors.forename: O
authors.initials: O
authors.lastname: Zak
authors.forename: C
authors.initials: C
authors.lastname: McRill
authors.forename: C
authors.initials: C
authors.lastname: Shen
authors.forename: G
authors.initials: G
authors.lastname: Di Chiro
mesh_terms: D000818:Animals; D001052:Apoferritins / Q000032:analysis / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D019327:Copper Sulfate; D004058:Diffusion; D004578:Electron Spin Resonance Spectroscopy; D005293:Ferritins / Q000032:analysis / Q000737:chemistry*; D007089:Image Enhancement; D007501:Iron / Q000032:analysis; D008279:Magnetic Resonance Imaging / Q000379:methods
chemical_list: D003300:Copper; D005293:Ferritins; D001052:Apoferritins; D007501:Iron; D019327:Copper Sulfate