Nerve growth factor precursors in the rat thyroid and hippocampus.
A nerve growth factor (NGF) precursor form of about 24 kDa was identified in homogenates of rat thyroid and hippocampus by immunoprecipitation using three sera raised against a synthetic peptide that reproduces the sequence -71 to -46 of the proNGF molecule. Besides this species, a 31 kDa protein, as well as a cleavage product of 12 kDa were also immunoprecipitated in both tissues by one of these sera.
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INSERM U 298, CHRU, Angers, France.
D000818:Animals; D006168:Guinea Pigs; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D008970:Molecular Weight; D009414:Nerve Growth Factors / Q000096:biosynthesis* / Q000276:immunology; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000276:immunology; D010446:Peptide Fragments / Q000276:immunology; D011467:Prostate / Q000378:metabolism; D011498:Protein Precursors / Q000096:biosynthesis* / Q000276:immunology; D051381:Rats; D012160:Retina / Q000166:cytology / Q000378:metabolism; D013737:Testis / Q000378:metabolism; D013961:Thyroid Gland / Q000378:metabolism*
D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D010446:Peptide Fragments; D011498:Protein Precursors