IP3 receptor: localization to plasma membrane of T cells and cocapping with the T cell receptor.
Immune responses in lymphocytes require cellular accumulation of large amounts of calcium (Ca2+) from extracellular sources. In the T cell tumor line Jurkat, receptors for the Ca(2+)-releasing messenger inositol 1,4,5-trisphosphate (IP3) were localized to the plasma membrane (PM). Capping of the T cell receptor-CD3 complex, which is associated with signal transduction, was accompanied by capping of IP3 receptors. The IP3 receptor on T cells appears to be responsible for the entry of Ca2+ that initiates proliferative responses.
Khan
A A
AA
Johns Hopkins University School of Medicine, Department of Neuroscience, Baltimore, MD 21205.
Steiner
J P
JP
Klein
M G
MG
Schneider
M F
MF
Snyder
S H
SH
D015703:Antigens, CD / Q000378:metabolism; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis / Q000378:metabolism*; D002051:Burkitt Lymphoma; D017252:CD3 Complex; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism*; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D005455:Fluorescent Antibody Technique; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism*; D053496:Inositol 1,4,5-Trisphosphate Receptors; D007700:Kinetics; D011948:Receptors, Antigen, T-Cell / Q000032:analysis / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000032:analysis / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear; D015290:Second Messenger Systems; D013601:T-Lymphocytes / Q000276:immunology*
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D015220:Calcium Channels; C506926:ITPR1 protein, human; D053496:Inositol 1,4,5-Trisphosphate Receptors; D011948:Receptors, Antigen, T-Cell; D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; D003208:Concanavalin A; D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium