Optimal stimulation of paralyzed muscle after human spinal cord injury.
Muscle properties change profoundly as a result of disuse after spinal cord injury. To study the extent to which these changes can be reversed by electrical stimulation, tibialis anterior muscles in complete spinal cord-injured subjects were stimulated for progressively longer times (15 min, 45 min, 2 h, and 8 h/day) in 6-wk intervals. An index of muscle endurance to repetitive stimulation doubled (from 0.4 to 0.8), contraction and half-relaxation times increased markedly (from 70 to approximately 100 ms), but little or no change was measured in twitch or tetanic tension with increasing amounts of stimulation. The changes observed with 2 h/day of stimulation brought the physiological values close to those for normal (control) subjects. A decrease in the stimulation period produced a reversal of the changes. No effects were observed in the contralateral (unstimulated) muscle at any time, nor was there evidence of decreased numbers of motor units in these subjects secondary to spinal cord injury. Motor unit properties changed in parallel with those of the whole muscle. The occasional spasms occurring in these subjects are not sufficient to maintain normal muscle properties, but these properties can largely be restored by 1-2 h/day of electrical stimulation.
Stein
R B
RB
Division of Neuroscience, University of Alberta, Edmonton, Canada.
Gordon
T
T
Jefferson
J
J
Sharfenberger
A
A
Yang
J F
JF
de Zepetnek
J T
JT
Belanger
M
M
D000222:Adaptation, Physiological; D000328:Adult; D004599:Electric Stimulation Therapy / Q000379:methods*; D005221:Fatigue / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D009046:Motor Neurons / Q000502:physiology; D009119:Muscle Contraction / Q000502:physiology; D009126:Muscle Relaxation / Q000502:physiology; D009410:Nerve Degeneration / Q000502:physiology; D009469:Neuromuscular Junction / Q000502:physiology; D010243:Paralysis / Q000503:physiopathology / Q000628:therapy*; D013119:Spinal Cord Injuries / Q000503:physiopathology / Q000628:therapy*; D009435:Synaptic Transmission / Q000502:physiology