Effects of methylcobalamin on diabetic neuropathy.
We studied the clinical and neurophysiological effects of methylcobalamin on patients with diabetic neuropathy. In a double-blind study, the active group showed statistical improvement in the somatic and autonomic symptoms with regression of signs of diabetic neuropathy. Motor and sensory nerve conduction studies showed no statistical improvement after 4 months. The drug was easily tolerated by the patients and no side effects were encountered.
Yaqub
B A
BA
Division of Neurology, King Khalid University Hospital, Riyadh, Saudi Arabia.
Siddique
A
A
Sulimani
R
R
D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000503:physiopathology; D003929:Diabetic Neuropathies / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009460:Neurologic Examination / Q000187:drug effects; D010525:Peripheral Nerves / Q000187:drug effects / Q000503:physiopathology; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012026:Reflex, Stretch / Q000187:drug effects / Q000502:physiology; D012677:Sensation / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology; D014805:Vitamin B 12 / Q000031:analogs & derivatives* / Q000627:therapeutic use
C019476:mecobalamin; D014805:Vitamin B 12