Adjuvant properties of propionibacterium avidum KP-40 in vaccination against endemic viral and bacterial infections. I. Swine immunized with live attenuated Aujeszky's disease virus vaccine and experimentally infected with virulent viruses.
Forty 5-month old swine were treated with immunomodulating Propionibacterium avidum KP-40 (PA) and/or immunized with live attenuated Aujeszky's disease (AD) virus vaccine (SuivacA); 8 weeks later all animals were infected with virulent AD viruses (NIA-3). Seven of 10 swine vaccinated without PA developed mild/moderate symptoms of infection with 3- to 5-day fever and a temporary halt in weight gain. Application of PA together with the vaccine lowered the morbidity rate, shortened the period of fever and speeded recovery. Only low levels of virus-neutralizing IgG antibodies were found in vaccinated swine and application of PA did not influence antibody titers.
Markowska-Daniel
I
I
Department of Swine Diseases, National Institute of Veterinary Research, Pulawy, Poland.
Pejsak
Z
Z
Szmigielski
S
S
Jeljaszewicz
J
J
Pulverer
G
G
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D005069:Evaluation Studies as Topic; D011558:Herpesvirus 1, Suid / Q000276:immunology*; D007074:Immunoglobulin G / Q000096:biosynthesis; D011424:Propionibacterium / Q000276:immunology*; D011557:Pseudorabies / Q000517:prevention & control; D013552:Swine; D013553:Swine Diseases / Q000517:prevention & control; D014613:Vaccines, Attenuated / Q000008:administration & dosage; D014765:Viral Vaccines / Q000008:administration & dosage*
D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D007074:Immunoglobulin G; D014613:Vaccines, Attenuated; D014765:Viral Vaccines