title: Histologic follow-up of ampullary adenomas in patients with familial adenomatosis coli.
abstract: BACKGROUND
  The major duodenal papilla is a common site of extracolonic adenoma in patients with familial adenomatosis coli (FAC). However, there have been no reports which have systematically discussed histologic change in atypia of ampullary adenomas with time by their location in the papilla.
  
  
  RESULTS
  The major duodenal papillae of 23 patients with FAC were followed endoscopically and histologically for an average of 7.7 years (range, 1 year to 14 years 7 months). Tubular adenomas were detected histologically in 17 of the 23 patients at the first (14) or following examinations (3). They occurred in the orifice and/or ampulla in 11 patients and in the surface of the papilla in 8 patients. Three of the 11 orifice and/or ampulla adenomas contained moderate to severe atypia. There was no histologic change in atypia or malignant transformation during the follow-up period.
  
  
  CONCLUSIONS
  In the patients with FAC, the major duodenal papilla had adenoma, i.e., precancerous lesion, at a high incidence (74%), and it is reported that the ampulla of the papilla tended to have extracolonic carcinoma. Therefore, it is necessary to follow duodenal papillae of patients with FAC carefully and take biopsy specimens repeatedly from various sites, especially from the orifice or ampulla even if the papilla seems to be normal.
authors.affiliation: 1st Department of Pathology, Niigata University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Noda
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
authors.forename: M
authors.initials: M
authors.lastname: Iida
authors.forename: R
authors.initials: R
authors.lastname: Narisawa
authors.forename: I
authors.initials: I
authors.lastname: Kurosaki
authors.forename: M
authors.initials: M
authors.lastname: Iwafuchi
authors.forename: M
authors.initials: M
authors.lastname: Satoh
authors.forename: Y
authors.initials: Y
authors.lastname: Ajioka
mesh_terms: D000236:Adenoma / Q000473:pathology*; D011125:Adenomatous Polyposis Coli / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D014670:Ampulla of Vater / Q000473:pathology*; D001706:Biopsy; D002455:Cell Division; D002471:Cell Transformation, Neoplastic; D002648:Child; D003138:Common Bile Duct Neoplasms / Q000473:pathology*; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged