Tissue specific expression of angiotensin converting enzyme.
Angiotensin converting enzyme (ACE) is a component of the renin-angiotensin system and is critical in the homeostatic control of systemic blood pressure. There are two isozymes of ACE that result from two distinct promoter regions with the single ACE gene. In this article, we discuss the biochemistry of tissue specific promoter recognition as exemplified by the ACE gene.
Bernstein
K E
KE
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322.
Howard
T E
TE
Shai
S Y
SY
Langford
K G
KG
Balogh
R
R
D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D005091:Exons; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D007438:Introns; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D007703:Peptidyl-Dipeptidase A / Q000235:genetics / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D013737:Testis / Q000201:enzymology; D014018:Tissue Distribution
D007527:Isoenzymes; D004247:DNA; D007703:Peptidyl-Dipeptidase A