title: Topoisomerase-targeting antitumor drugs: mechanisms of cytotoxicity and resistance.
authors.forename: L F
authors.initials: LF
authors.lastname: Liu
authors.forename: P
authors.initials: P
authors.lastname: D'Arpa
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002166:Camptothecin / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects; D016923:Cell Death / Q000187:drug effects; D004249:DNA Damage; D004273:DNA, Neoplasm / Q000378:metabolism; D004278:DNA, Superhelical / Q000378:metabolism; D004351:Drug Resistance; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000201:enzymology
chemical_list: D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D004278:DNA, Superhelical; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; D002166:Camptothecin