Expression of HLA-DR in intrahepatic cholangiocarcinoma.
Expression of HLA-DR was investigated immunohistochemically in 20 cases of intrahepatic cholangiocarcinoma, as well as 9 normal livers that had been obtained at autopsy. Five of the nine normal livers had peribiliary glands that showed HLA-DR. Positive staining for HLA-DR on tumor cells was observed in 6 of 13 cases of cholangiocarcinoma of the hepatic hilus and in only 1 of 7 cases of peripheral cholangiocellular carcinoma. In cholangiocarcinomas of the hepatic hilus, the 5-year survival rate for tumors that had positive staining for HLA-DR was better than that for tumors that had negative staining. Based on these results, the presence or absence of HLA-DR on tumor cells could have a pathologic significance for intrahepatic cholangiocarcinoma.
Torii
A
A
Department of Surgery II, Nagoya University, School of Medicine, Japan.
Harada
A
A
Nakao
A
A
Nonami
T
T
Nakayama
A
A
Ito
M
M
Takagi
H
H
D002759:Adenoma, Bile Duct / Q000276:immunology*; D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis; D001650:Bile Duct Neoplasms / Q000276:immunology*; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis*; D006500:Hepatic Duct, Common / Q000276:immunology*; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000276:immunology; D008113:Liver Neoplasms / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis
D000906:Antibodies; D015295:Antigens, Tumor-Associated, Carbohydrate; D006684:HLA-DR Antigens