title: Effect of age and sex on glomerular filtration rate measured by 51Cr-EDTA.
abstract: 1. The effect of age and sex on glomerular filtration rate (GFR) was measured by the 51Cr-EDTA radioisotopic method in 76 normal individuals (43 women and 33 men). 2. Age has a significant effect on GFR. Subjects aged 41 to 60 years have GFR values [104.5 +/- 16.5 ml min-1 (1.73 m2)-1, N = 43] lower than younger individuals aged 20 to 40 years [116.6 +/- 11.2 ml min-1 (1.73 m2)-1, N = 33]. GFR decreases after 40 years of age by approximately 6.0 ml min-1 (1.73 m2)-1 per decade. 3. GFR values in women [105.9 +/- 16.0 ml min-1 (1.73 m2)-1, N = 43] were lower when compared to men [114.8 +/- 14.3 ml min-1 (1.73 m2)-1, N = 33]. 4. We conclude that the effect of sex and age must be taken into account when establishing reference values for GFR.
authors.affiliation: Serviço de Endocrinologia, Hospital de Clínicas de Porto Alegre, Brasil.
authors.forename: J L
authors.initials: JL
authors.lastname: Gross
authors.forename: R
authors.initials: R
authors.lastname: Friedman
authors.forename: M J
authors.initials: MJ
authors.lastname: Azevedo
authors.forename: S P
authors.initials: SP
authors.lastname: Silveiro
authors.forename: M
authors.initials: M
authors.lastname: Pecis
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology*; D002860:Chromium Radioisotopes; D004492:Edetic Acid; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012727:Sex Characteristics
chemical_list: D002860:Chromium Radioisotopes; D004492:Edetic Acid