title: Chronic active Epstein-Barr virus infection in an adult.
abstract: We report a rare adult case of chronic active Epstein-Barr virus (EBV) infection. A 54-year-old woman was admitted to our hospital with intermittent fever, weight loss, hepatosplenomegaly, pancytopenia and liver disturbance. In serological tests for EBV, anti-virus capsid antigen (VCA)-IgG antibody and anti-early antigen (EA)-IgG antibody were markedly elevated and anti-EBV nuclear antigen (EBNA) antibody was negative. EBV genome was detected in the bone marrow nucleated cells and peripheral lymphocytes by Southern blot hybridization. The patient developed left facial edema, bilateral breast tumor and pneumonia. She died one year after admission in spite of the administration of prednisolone, interferon and acyclovir.
authors.affiliation: Third Department of Internal Medicine, Nara Medical University, Kashihara, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sakamoto
authors.forename: M
authors.initials: M
authors.lastname: Uemura
authors.forename: H
authors.initials: H
authors.lastname: Fukui
authors.forename: M
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: K
authors.initials: K
authors.lastname: Fukui
authors.forename: K
authors.initials: K
authors.lastname: Kinoshita
authors.forename: H
authors.initials: H
authors.lastname: Kojima
authors.forename: T
authors.initials: T
authors.lastname: Matsumori
authors.forename: T
authors.initials: T
authors.lastname: Tsujii
authors.forename: R
authors.initials: R
authors.lastname: Sumazaki
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000956:Antigens, Viral / Q000097:blood; D015139:Blotting, Southern; D001943:Breast Neoplasms / Q000209:etiology; D036022:Capsid Proteins; D002908:Chronic Disease; D004268:DNA-Binding Proteins / Q000097:blood; D004487:Edema / Q000209:etiology; D019309:Epstein-Barr Virus Nuclear Antigens; D005260:Female; D006505:Hepatitis / Q000209:etiology; D006566:Herpesviridae Infections / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D016898:Interferon-alpha / Q000627:therapeutic use; D008099:Liver / Q000473:pathology; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D000956:Antigens, Viral; D036022:Capsid Proteins; D004268:DNA-Binding Proteins; D019309:Epstein-Barr Virus Nuclear Antigens; C041788:Epstein-Barr viral capsid antigen; C033305:Epstein-Barr virus early antigen; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D016898:Interferon-alpha; D011239:Prednisolone; D000212:Acyclovir