On the protonophoric activity of oxazolomycin.
By the use of an artificial lipid membrane model we have shown that the antibiotic oxazolomycin (Streptomyces albus) is an effective protonophore at pH < 7.0 but conveys both protons and monovalent cations such as potassium at pH > 7.5 as a passive carrier. The ionophoric properties are suggested to be correlated with its antibacterial, antiviral, and cytotoxic activities.
Grigorjev
P A
PA
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino na Oke, Moscow region.
Schlegel
R
R
Gräfe
U
U
D004573:Electrolytes / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D008566:Membranes / Q000737:chemistry / Q000187:drug effects; D010080:Oxazoles / Q000494:pharmacology*; D011189:Potassium Chloride / Q000737:chemistry; D011522:Protons; D011760:Pyrrolidinones; D013141:Spiro Compounds / Q000494:pharmacology*
D004573:Electrolytes; D010080:Oxazoles; D011522:Protons; D011760:Pyrrolidinones; D013141:Spiro Compounds; C077919:diffusomycin; D011189:Potassium Chloride