title: Immunogenicity of enhanced potency inactivated polio vaccine.
abstract: Fifty two children were immunized with two doses of enhanced potency inactivated polio vaccine in order to determine its efficacy. The vaccine was very efficacious with 92.3, 92.3 and 88.3% of the children seroconverting to the three poliovirus types, respectively. The vaccine was equally efficacious whether the two doses were given at 4-week or 8-week intervals or when immunization was started at 6-7 weeks of age or later. The presence of maternal antibodies did not interfere significantly with the seroresponse to two doses of IPV-E. The study recommends that two doses of IPV-E give satisfactory seroconversion rates. Immunization can be started as early as 6 weeks age and the two doses can be given at 4 weeks interval to complete primary immunization against poliomyelitis.
authors.affiliation: Department of Pediatrics, Lady Hardinge Medical College, New Delhi.
authors.forename: J
authors.initials: J
authors.lastname: Singh
authors.forename: R N
authors.initials: RN
authors.lastname: Ravi
authors.forename: A K
authors.initials: AK
authors.lastname: Dutta
authors.forename: S
authors.initials: S
authors.lastname: Kumari
authors.forename: S
authors.initials: S
authors.lastname: Khare
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D011051:Poliomyelitis / Q000517:prevention & control; D017955:Poliovirus / Q000276:immunology*; D011054:Poliovirus Vaccine, Inactivated / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D011054:Poliovirus Vaccine, Inactivated