[False rubella diagnosis in pregnancy by IgM enzyme immunoassay].
On the basis of a case report of a false-positive rubella diagnosis in early pregnancy the interpretation of positive IgM is discussed. A primigravida at 14 weeks of gestation showed rubella-specific IgM in an enzyme immunoassay. This result could not be confirmed by an alternative method (hemagglutination-inhibiting test after separating the serum by density gradients into different immunoglobulin classes and removal of the IgG with protein A). The immunological status corresponded with a past rubella infection or with the status after vaccination (IgG-positive). It is therefore recommended to use an additional method in the presence of IgM, especially if an interruption of the pregnancy has to be considered. In the course of the examination a recent cytomegalovirus infection could be detected.
Grüninger
T
T
Maternité Inselhof Triemli, Zürich, Schweiz.
Wunderli
W
W
Böhlen-Bodmer
A E
AE
Dobec
M
M
Keller
A
A
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000175:diagnosis; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007075:Immunoglobulin M / Q000032:analysis*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis* / Q000276:immunology; D012409:Rubella / Q000175:diagnosis* / Q000276:immunology
D000914:Antibodies, Viral; D007075:Immunoglobulin M; C040901:rubella antibodies
Falsche Rubella-Diagnose in der Schwangerschaft aufgrund eines IgM-Enzymimmunoassays.