title: Photoaffinity labeling of the electroplax sodium channel with a photoreactive mu-conotoxin carrying a radioactive and chromogenic diazirine.
abstract: Photoreactive derivatives of mu-conotoxin GIIIA carrying a radioactive and chromogenic diazirine have been prepared as a photoaffinity labeling reagent for muscle-type sodium channels. When the reagent was photolyzed in the presence of the eel sodium channel, radioactivity was specifically incorporated into the channel protein.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hatanaka
authors.forename: H
authors.initials: H
authors.lastname: Nakayama
authors.forename: Y
authors.initials: Y
authors.lastname: Kanaoka
mesh_terms: D000345:Affinity Labels; D000595:Amino Acid Sequence; D000818:Animals; D020916:Conotoxins; D004557:Electric Organ / Q000378:metabolism* / Q000502:physiology; D004593:Electrophorus; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000737:chemistry*; D010777:Photochemistry; D015222:Sodium Channels / Q000378:metabolism*
chemical_list: D000345:Affinity Labels; D020916:Conotoxins; D010456:Peptides, Cyclic; D015222:Sodium Channels; C046101:conotoxin GIII