title: Use of the urinary protein creatinine index to assess proteinuria in renal transplant patients.
abstract: The use of 24-h urine protein collections for the assessment of proteinuria in renal transplant patients has been compared with the protein creatinine index (PCI) obtained from spot urine samples. Paired data from 148 patients showed a correlation of 0.77 (P less than 0.001) between 24-h protein excretion and the PCI. A PCI of 750 identified proteinuria of greater than 1.0 g/24 h with a sensitivity of 89% and a specificity of 93%. The predictive value of a positive test was 81% and that of a negative test 96%. Similar performance was observed for the detection of proteinuria of differing severities ranging from 0.5 g/24 h to 2.0 g/24 h. The use of spot testing was popular with both patients and staff, and reduced the sample handling cost to 15% of that of 24-h urine collection. We recommend that PCI be adopted as the standard outpatient test for the assessment of proteinuria following renal transplantation.
authors.affiliation: Department of Renal Medicine, St James's University Hospital, Leeds, UK.
authors.forename: E H
authors.initials: EH
authors.lastname: Dyson
authors.forename: E J
authors.initials: EJ
authors.lastname: Will
authors.forename: A M
authors.initials: AM
authors.lastname: Davison
authors.forename: A H
authors.initials: AH
authors.lastname: O'Malley
authors.forename: H T
authors.initials: HT
authors.lastname: Shepherd
authors.forename: R G
authors.initials: RG
authors.lastname: Jones
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003404:Creatinine / Q000652:urine*; D005069:Evaluation Studies as Topic; D006801:Humans; D016030:Kidney Transplantation / Q000502:physiology*; D008875:Middle Aged; D011507:Proteinuria / Q000175:diagnosis* / Q000652:urine
chemical_list: D003404:Creatinine