Erythrocyte membrane sodium-potassium adenosine triphosphatase activity in affective disorders.
Erythrocyte membrane Na+,K(+)-ATPase activity was studied in drug naive patients with bipolar (BP) mania (n = 62) and unipolar (UP) depression (n = 60) and normal controls (n = 66). Compared to controls there was a significantly decreased Na+,K(+)-ATPase activity in UP depressives but no change in BP manics. However, lithium treatment caused a significant increase in Na+,K(+)-ATPase activity although there was no correlation between plasma lithium levels and enzyme activity. Plasma cortisol correlated inversely with Na+,K(+)-ATPase in UP depressives. Interestingly, the lithium responders [less than 50% Beck Rafaelson's Mania Rating Scale (BRMS) score] showed a significant increase in Na+,K(+)-ATPase activity compared to lithium nonresponders (greater than 50% BRMS score). These observations indicate that monitoring of Na+,K(+)-ATPase activity during lithium therapy is useful to predict a therapeutic response.
Reddy
P L
PL
Department of Neurochemistry, National Institute of Mental Health and Neurosciences, Bangalore, India.
Khanna
S
S
Subhash
M N
MN
Channabasavanna
S M
SM
Rao
B S
BS
D000328:Adult; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy / Q000201:enzymology*; D003866:Depressive Disorder / Q000097:blood / Q000201:enzymology*; D004910:Erythrocyte Membrane / Q000201:enzymology*; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008094:Lithium / Q000627:therapeutic use; D008297:Male; D011388:Prolactin / Q000097:blood; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood*; D013972:Thyrotropin / Q000097:blood
D011388:Prolactin; D013972:Thyrotropin; D013006:Growth Hormone; D008094:Lithium; D000254:Sodium-Potassium-Exchanging ATPase; D006854:Hydrocortisone