[Changes in the calcium channel of the sarcoplasmic reticulum (the ryanodine receptor) during myocardial ischemia].
We determined 3H-ryanodine binding in isolated rat hearts subjected to aerobic perfusion or to global normothermic ischemia (10-30 min). Ischemia produced a significant reduction in the number of ryanodine binding sites, while the dissociation constant of the binding reaction was unaffected.
Zucchi
R
R
Istituto di Cardiologia, Università degli Studi, Pisa.
Ronca-Testoni
S
S
Yu
G
G
Galbani
P
P
Ronca
G
G
Mariani
M
M
D000332:Aerobiosis; D000818:Animals; D015220:Calcium Channels / Q000378:metabolism*; D066298:In Vitro Techniques; D017202:Myocardial Ischemia / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D011950:Receptors, Cholinergic / Q000378:metabolism*; D019837:Ryanodine Receptor Calcium Release Channel; D012519:Sarcoplasmic Reticulum / Q000378:metabolism*
D015220:Calcium Channels; D011950:Receptors, Cholinergic; D019837:Ryanodine Receptor Calcium Release Channel
Alterazione del canale del calcio del reticolo sarcoplasmatico (recettore della ryanodina) durante ischemia miocardica.