[Free radicals and their biological significance: present and future].
Free radicals are usually active species which have unpair electron (S) in molecules or Atomic groups. Of the free radicals, O2- and .OH could easily be produced in mammalian cells, by oxidation and reduction cycle catalyzed by fravoproteins and by iron + H2O2 reaction, respectively. Other free radicals would also be produced in mammalian cell, such as amino acid radicals, semiquinone radicals and flavine radicals etc. In general, free radicals cause cell injury though membrane lipid peroxidation and DNA strand cleavage and some other mechanisms.
Nakano
M
M
Photon Medical Research Center, Hamamatsu University, School of Medicine, Japan.
D004249:DNA Damage; D004578:Electron Spin Resonance Spectroscopy; D004579:Electron Transport; D005609:Free Radicals; D006801:Humans; D006878:Hydroxides / Q000032:analysis / Q000378:metabolism*; D007249:Inflammation / Q000378:metabolism; D015227:Lipid Peroxidation; D008861:Microsomes / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D009504:Neutrophils / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000032:analysis / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism
D005609:Free Radicals; D006878:Hydroxides; D017382:Reactive Oxygen Species; D013481:Superoxides