title: Macrophage association of polyomavirus in progressive multifocal leukoencephalopathy: an immunohistochemical and ultrastructural study. Case report.
abstract: Progressive multifocal leukoencephalopathy (PML) in a patient following autologous bone marrow transplantation for a non-Hodgkin's centroblastic lymphoma was studied by immunohistochemistry and transmission electron microscopy. Our observations indicate that a large amount of polyomavirus, most probably JC virus, is taken up and segregated within vacuoles of macrophages by phagocytosis. A relevant role of macrophages in the pathogenesis of PML is emphasized.
authors.affiliation: Immunopathology Laboratory, Karolinska Hospital, Stockholm, Sweden.
authors.forename: R
authors.initials: R
authors.lastname: Mesquita
authors.forename: C
authors.initials: C
authors.lastname: Parravicini
authors.forename: M
authors.initials: M
authors.lastname: Björkholm
authors.forename: M
authors.initials: M
authors.lastname: Ekman
authors.forename: P
authors.initials: P
authors.lastname: Biberfeld
mesh_terms: D001921:Brain / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007577:JC Virus / Q000254:growth & development; D007968:Leukoencephalopathy, Progressive Multifocal / Q000382:microbiology* / Q000473:pathology; D008264:Macrophages / Q000382:microbiology*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D011120:Polyomavirus / Q000254:growth & development*