title: [Identification of a segment of the gene for the substance B receptor in the human DNA genome using the polymerase chain reaction].
abstract: Polymerase chain reaction was applied to human genomic DNA using primers corresponding to the rat substance P receptor cDNA. As a result, a fragment of 94 b.p. was isolated identical to the fragment 771-864 of the above-mentioned cDNA, with the exception of the G796----A substitution (Val----Ile in the amino acid sequence). A comparison of the established sequence with the published structures of tachykinin receptors of NK-1, NK-2 and NK-3 types allows its assignment to the substance P receptor (NK-1 tachykinin receptor) gene detected in the human genome.
authors.forename: A A
authors.initials: AA
authors.lastname: Barinov
authors.forename: A B
authors.initials: AB
authors.lastname: Kuriatov
authors.forename: I B
authors.initials: IB
authors.lastname: Mertsalov
authors.forename: L O
authors.initials: LO
authors.lastname: Martsen
authors.forename: V I
authors.initials: VI
authors.lastname: Tsetlin
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D004247:DNA; D015894:Genome, Human; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D018040:Receptors, Neurokinin-1; D017981:Receptors, Neurotransmitter / Q000235:genetics*; D018039:Receptors, Tachykinin; D012689:Sequence Homology, Nucleic Acid; D015320:Tachykinins / Q000378:metabolism
chemical_list: D018040:Receptors, Neurokinin-1; D017981:Receptors, Neurotransmitter; D018039:Receptors, Tachykinin; D015320:Tachykinins; D004247:DNA
vernacular_title: Identifikatsiia uchastka gena retseptora veshchestva P v genomnoĭ DNK cheloveka s pomoshch'iu polimeraznoĭ tsepnoĭ reaktsii.