title: Sleep shift dissociates the nocturnal peaks of parathyroid hormone (1-84), nephrogenous cyclic adenosine monophosphate, and prolactin in normal men.
abstract: The secretion of PTH(1-84) and PRL over a 24-h period in normal subjects has been shown to be highly correlated, with changes in PRL occurring approximately 2 h after those in PTH(1-84). It has been postulated that there may be neuroendocrine control common to PTH(1-84) and PRL. As the secretion of PRL is known to be strongly influenced by sleep we investigated the effect of a 7-h acute sleep shift on the nocturnal secretion of PTH(1-84), PRL, and nephrogenous cAMP, a marker of PTH(1-84) bioactivity. Six normal male subjects were studied on two occasions (study A sleep, 0100-0800 h; study B, 0800-1400 h) with samples withdrawn at 30-min intervals. Sleep shift produced the expected shift in PRL secretion to new time of sleep. The overall timing of the PTH(1-84) nocturnal peak (0200-0600 h) was not altered by sleep shift. However, the start of the rise in PTH(1-84) (0200-0300 h) was blunted (P less than 0.05), and the peak of nephrogenous cAMP, coincident with the nocturnal rise in PTH(1-84) in study A, was markedly attenuated (P less than 0.01). Thus whereas the results of this study argue against a direct neuroendocrine link between PTH(1-84) and PRL, it is postulated that sleep shift disrupts a high degree of temporal organization which, under normal conditions, may allow concerted metabolic effects between PTH(1-84) and other hormones over a 24-h period.
authors.affiliation: Institute of Biochemistry, Royal Infirmary, Glasgow, Scotland.
authors.forename: F C
authors.initials: FC
authors.lastname: Logue
authors.forename: W D
authors.initials: WD
authors.lastname: Fraser
authors.forename: D S
authors.initials: DS
authors.lastname: O'Reilly
authors.forename: J
authors.initials: J
authors.lastname: Christie
authors.forename: D A
authors.initials: DA
authors.lastname: Cameron
authors.forename: D C
authors.initials: DC
authors.lastname: Wallace
authors.forename: G H
authors.initials: GH
authors.lastname: Beastall
mesh_terms: D000328:Adult; D002118:Calcium / Q000032:analysis; D002940:Circadian Rhythm; D000242:Cyclic AMP / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008297:Male; D010281:Parathyroid Hormone / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism*; D012890:Sleep / Q000502:physiology*
chemical_list: D010281:Parathyroid Hormone; D011388:Prolactin; D000242:Cyclic AMP; D002118:Calcium