Comparative sequence analyses of Epstein-Barr virus nuclear antigen-2 and -3B genes of a fresh Epstein-Barr virus-2 isolate.
The nucleotide sequence of Epstein-Barr virus (EBV) nuclear antigen (EBNA)-2 and EBNA-3B regions of an EBV-2 isolate in Japan was analyzed. The deduced amino acid sequences of EBNA-2 and EBNA-3B of the isolate and a prototype EBV-2 strain AG876 were identical, but the number of the repeated sequence in EBNA-3B was variable as that of IR-3 in EBNA-1. The remarkably well-conserved sequence seems to suggest that the structure of the EBNA-2 and EBNA-3B genes of EBV-2 is crucial for their function in virus replication.
Inoue
N
N
Department of Virology, National Institute of Health, Tokyo, Japan.
Kikuta
H
H
Yanagi
K
K
D000956:Antigens, Viral / Q000235:genetics*; D001483:Base Sequence; D002467:Cell Nucleus / Q000276:immunology*; D004268:DNA-Binding Proteins / Q000235:genetics*; D019309:Epstein-Barr Virus Nuclear Antigens; D005814:Genes, Viral; D004854:Herpesvirus 4, Human / Q000276:immunology*; D008969:Molecular Sequence Data
D000956:Antigens, Viral; D004268:DNA-Binding Proteins; D019309:Epstein-Barr Virus Nuclear Antigens