Antilipoxygenase activity of amyrin triterpenes.
Triterpenes--alpha-amyrin acetate, beta-amyrin acetate and beta-amyrin were tested for their effects on the synthesis of 5-lipoxygenase products in human neutrophils. All the triterpenes reduced 5-HETE synthesis without effect on LTB4 synthesis. The relative effects suggest that 5-HETE inhibition can explain the antiarthritic activity possessed by these compounds.
Kweifio-Okai
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Department of Anatomy and Physiology, Royal Melbourne Institute of Technology, Bundoora, Australia.
Macrides
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TA
D005260:Female; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000096:biosynthesis; D066298:In Vitro Techniques; D007975:Leukotriene B4 / Q000096:biosynthesis; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects* / Q000201:enzymology; D009828:Oleanolic Acid / Q000031:analogs & derivatives; D014315:Triterpenes / Q000494:pharmacology*
D006893:Hydroxyeicosatetraenoic Acids; D016859:Lipoxygenase Inhibitors; D014315:Triterpenes; D007975:Leukotriene B4; C022022:5-hydroxy-6,8,11,14-eicosatetraenoic acid; D009828:Oleanolic Acid; C036380:beta-amyrin