Exploring the pathways of homologous recombination.
There has been significant progress in elucidating the mechanisms by which meiotic and mitotic recombination occur. Double-strand breaks in particular have been the object of attention in studies on meiotic gene conversion, site-specific mitotic recombination, the repair of transposon excision and the transformation of cells with linearized DNA. A combination of genetic analysis and physical studies of molecular recombination intermediates have established that double-strand breaks can occur by two different mechanisms.
Haber
J E
JE
Rosenstiel Center, Brandeis University, Waltham, Massachusetts 02254.
D000818:Animals; D004260:DNA Repair / Q000235:genetics; D004251:DNA Transposable Elements; D004277:DNA, Single-Stranded / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D008540:Meiosis / Q000235:genetics; D008938:Mitosis / Q000235:genetics; D008957:Models, Genetic; D011995:Recombination, Genetic; D012689:Sequence Homology, Nucleic Acid
D004251:DNA Transposable Elements; D004277:DNA, Single-Stranded