title: Genetic predisposing factors in non-insulin dependent diabetes with persistent albuminuria.
abstract: We designed this study to elucidate a possible involvement of genetic factors which influence the progression of renal dysfunction in patients with non-insulin dependent diabetes mellitus (NIDDM). A total of 328 patients was randomly selected in the Tokai University Hospital. They had been cared for in our hospital as NIDDM for the past five years, until April, 1989. Fifty-six patients with persistent albuminuria, and an equal number of patients without persistent albuminuria were included in this study. No significant differences were observed between the two groups in terms of age, estimated period of illness, blood pressure, body-mass index, HbAlc, blood glucose, total cholesterol, triglyceride level and mean blood pressure. The family histories obtained by questionnaires revealed that there might be some genetic predisposing factors leading to the onset of nephropathy in patients with NIDDM, especially in cases with paternal high blood pressure. It is suggested that paternal hypertension might be related to the development of nephropathy in patients with NIDDM.
authors.affiliation: Department of Internal Medicine, School of Medicine, Tokai University, Kanagawa, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Takeda
authors.forename: K
authors.initials: K
authors.lastname: Ohta
authors.forename: M
authors.initials: M
authors.lastname: Hagiwara
authors.forename: K
authors.initials: K
authors.lastname: Hori
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: D
authors.initials: D
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: H
authors.initials: H
authors.lastname: Machimura
authors.forename: M
authors.initials: M
authors.lastname: Yagame
authors.forename: H
authors.initials: H
authors.lastname: Kaneshige
mesh_terms: D000368:Aged; D000419:Albuminuria / Q000150:complications / Q000235:genetics*; D017920:Antiporters / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics*; D003928:Diabetic Nephropathies / Q000097:blood / Q000150:complications / Q000235:genetics*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics; D008094:Lithium / Q000097:blood; D008297:Male; D008875:Middle Aged; D012964:Sodium / Q000097:blood; D011795:Surveys and Questionnaires
chemical_list: D017920:Antiporters; C045885:sodium-lithium countertransporter; D008094:Lithium; D012964:Sodium