title: Long-term decrease in body fat and in brown adipose tissue in capsaicin-desensitized rats.
abstract: Previous studies showed that atrophy of brown adipose tissue (BAT) of capsaicin-desensitized rats occurs rapidly and persists for up to 28 days. The rats do not, however, become any more obese than control rats, despite the frequent association of atrophied BAT with obesity. The objective of the present study was to assess longer-term effects of capsaicin desensitization on BAT and on energy balance. Rats were studied at 2.5, 3.5, and 8 mo after treatment. Major effects at 8 mo, mostly seen to a lesser extent at 3.5 mo but not at 2.5 mo, were a marked reduction in body weight that was largely attributable to a reduction in body fat but also to some stunting of growth and an atrophy or lack of growth of BAT (reduced weight and content of protein, DNA, cytochrome oxidase, and uncoupling protein). Resting metabolic rates and food intake at 8 mo were reduced in proportion to the smaller body size. We suggest that the lack of trophic influence of sensory neuropeptides on BAT proposed previously may extend to other organs, including white adipose tissue, and contribute to the reduced adiposity and the smaller body size of capsaicin-desensitized rats.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, University of Ottawa, Ontario, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Cui
authors.forename: J
authors.initials: J
authors.lastname: Himms-Hagen
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology*; D002001:Adipose Tissue, Brown / Q000033:anatomy & histology*; D000818:Animals; D001823:Body Composition; D001831:Body Temperature; D001835:Body Weight / Q000187:drug effects; D002211:Capsaicin / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D004361:Drug Tolerance; D003576:Electron Transport Complex IV / Q000378:metabolism; D004734:Energy Metabolism; D008297:Male; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D011506:Proteins; D004247:DNA; D003576:Electron Transport Complex IV; D002211:Capsaicin