A mouse c-ros genomic clone: identification of a highly conserved 22-amino acid segment in the juxta-membrane domain.
The mouse c-ros protooncogene genomic sequences have been cloned; an analysis of the partial genomic clone revealed a high conservation of the exons encoding the juxta-membrane (JM) and the 5' most protein tyrosine kinase domains. We have identified a segment of 22 amino acids conserved between the human and mouse JM domains; this segment may have a critical role in the function of the c-ros-encoded protein tyrosine kinase receptor.
Narayana
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Department of Hematology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Nagarajan
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L
D000595:Amino Acid Sequence; D000818:Animals; D003001:Cloning, Molecular; D051379:Mice; D008969:Molecular Sequence Data; D011505:Protein-Tyrosine Kinases / Q000737:chemistry / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000235:genetics*; D020794:Receptor Protein-Tyrosine Kinases; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000235:genetics*; D016415:Sequence Alignment
D011518:Proto-Oncogene Proteins; D011956:Receptors, Cell Surface; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases; C483813:Ros1 protein, mouse