Drosophila with postponed aging as a model for aging research.
Species of the genus Drosophila, commonly known as "fruitflies," are good model systems for research in aging. Drosophila are extremely well-known genetically, developmentally, and otherwise. They are also genetically analogous to mammalian species in most important respects. Previous work with Drosophila has been hampered by inbreeding depression, but more recent work using selection has created Drosophila with postponed aging that is inherited normally. Genetic transformation has also increased Drosophila life spans in some cases. Several biologic approaches have been applied to the analysis of genetically postponed aging in Drosophila: quantitative genetics, organismal physiology, and protein electrophoresis. Ultimately, these different approaches will be integrated into an overall analysis of aging in Drosophila, one that could be valuable for research with other taxa as well.
Rose
M R
MR
Department of Ecology and Evolutionary Biology, University of California, Irvine 92717.
Nusbaum
T J
TJ
Fleming
J E
JE
D000375:Aging / Q000235:genetics / Q000502:physiology*; D000818:Animals; D004330:Drosophila / Q000235:genetics / Q000502:physiology*; D008954:Models, Biological; D012106:Research