Fistularin 3 and 11-ketofistularin 3. Feline leukemia virus active bromotyrosine metabolites from the marine sponge Aplysina archeri.
Two brominated tyrosine metabolites, fistularin 3 [1] and a new compound 11-ketofistularin 3 [2] have been isolated from a marine sponge, Aplysina archeri. Their structures were determined on the basis of spectral data. Both compounds inhibited the growth of feline leukemia virus.
Gunasekera
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Harbor Branch Oceanographic Institution, Inc., Fort Pierce, Florida 34946.
Cross
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D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007555:Isoxazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005256:Leukemia Virus, Feline / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D011161:Porifera / Q000378:metabolism*; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D007555:Isoxazoles; C076217:11-ketofistularin 3; D014443:Tyrosine; C076216:fistularin 3