G protein-coupled receptors.
The diversity of the G protein-coupled receptor superfamily is now being realised with the molecular cloning of DNA encoding many new receptors and receptor subfamilies. The existing pharmacological definitions of receptor subtypes have been extended dramatically with identification of additional subtypes at the molecular level. Functional analysis of cloned receptors by expression in heterologous cell types has demonstrated that individual receptor subtypes can couple to a variety of different effector systems.
Iismaa
T P
TP
Garvan Institute of Medical Research, St Vincent's Hospital, Sydney, Australia.
Shine
J
J
D000818:Animals; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D013329:Structure-Activity Relationship
D008024:Ligands; D011956:Receptors, Cell Surface; D019204:GTP-Binding Proteins