title: Pharmacological profiles of the GABA and acetylcholine receptors from the nematode, Ascaris suum.
abstract: The pharmacological profiles of the acetylcholine and GABA receptors of Ascaris muscle have been investigated. Acetylcholine excites the muscle through activation of a nicotinic receptor which resembles the mammalian ganglionic receptor. DMPP is a potent agonist and alpha-bungarotoxin is a weak antagonist. GABA inhibits the muscle through activation of a chloride-linked receptor which in terms of agonist profile resembles the mammalian GABA-A receptor. However, bicuculline is inactive and picrotoxin is a very weak antagonist. Avermectin acts as a non-competitive antagonist at this GABA receptor with an IC-50 value in the low microM range.
authors.affiliation: Department of Physiology and Pharmacology, University of Southampton, U.K.
authors.forename: R J
authors.initials: RJ
authors.lastname: Walker
authors.forename: L
authors.initials: L
authors.lastname: Colquhoun
authors.forename: L
authors.initials: L
authors.lastname: Holden-Dye
mesh_terms: D000818:Animals; D017165:Ascaris suum / Q000378:metabolism*; D001640:Bicuculline / Q000494:pharmacology; D018680:Cholinergic Antagonists; D018756:GABA Antagonists; D058787:GABA-A Receptor Antagonists; D007559:Ivermectin / Q000031:analogs & derivatives / Q000494:pharmacology; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000494:pharmacology; D010276:Parasympatholytics / Q000494:pharmacology; D010277:Parasympathomimetics / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000378:metabolism*; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D001640:Bicuculline; D018680:Cholinergic Antagonists; D018756:GABA Antagonists; D058787:GABA-A Receptor Antagonists; D007559:Ivermectin; D009943:Organophosphorus Compounds; D010276:Parasympatholytics; D010277:Parasympathomimetics; D010852:Picrotoxin; D011950:Receptors, Cholinergic; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; C061388:3-aminopropylphosphinic acid; C019264:avermectin