[Hodgkin's disease in HIV infection--detection of Epstein-Barr virus DNA in tongue epithelium and lymphoma].
We present an HIV-infected patient with lymphadenopathy syndrome in whom an unusually aggressive case of Hodgkin's disease developed. Examination of tissue excised from the lymphoma and of epithelial cells scraped from the tongue of the patient revealed Epstein-Barr virus (EBV). The relationship between an enhanced replication of EBV in the epithelium of the tongue and the elevated frequency of Hodgkin's lymphomas containing EBV-DNA among HIV-infected patients is discussed.
Näher
H
H
Universitäts-Hautklinik Heidelberg.
Hartmann
M
M
Helfrich
S
S
Petzoldt
D
D
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D004279:DNA, Viral / Q000032:analysis*; D004848:Epithelium / Q000473:pathology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006689:Hodgkin Disease / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D009061:Mouth Mucosa / Q000473:pathology; D016133:Polymerase Chain Reaction; D014059:Tongue / Q000473:pathology*; D014412:Tumor Virus Infections / Q000188:drug therapy / Q000473:pathology*; D014779:Virus Replication / Q000187:drug effects / Q000502:physiology*
D004279:DNA, Viral
Morbus Hodgkin bei HIV-Infektion--Nachweis von Epstein-Barr-Virus-DNA in Zungenepithel und Lymphom.