Pyrogenic action of endothelin in conscious rabbit.
Injection of 0.3 nmol/kg endothelin(ET)-1 into the ear vein of conscious rabbits induced a significant increase in body temperature. ETB receptor specific agonist, namely 4-Ala-ET-1, also caused an elevation of the body temperature in a dose-dependent manner by injection into the ear vein of rabbit. These results suggest that ET play important roles in regulation of body temperature through selective stimulation of ETB receptor.
Koshi
T
T
Tokyo Research Laboratories, Kowa Co. Ltd., Japan.
Edano
T
T
Arai
K
K
Suzuki
C
C
Ehara
Y
Y
Hirata
M
M
Ohkuchi
M
M
Okabe
T
T
D000704:Analysis of Variance; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D016232:Endothelins / Q000008:administration & dosage / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D007275:Injections, Intravenous; D008297:Male; D011749:Pyrogens / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000502:physiology; D017466:Receptors, Endothelin; D012016:Reference Values; D013997:Time Factors
D016232:Endothelins; D011749:Pyrogens; D011956:Receptors, Cell Surface; D017466:Receptors, Endothelin; C061779:endothelin 1, Ala(1,3,11,15)-; D007213:Indomethacin