[A study of cyclic nucleotide acids in the serum in patients with myasthenia gravis].
The levels of cAMP and cGMP in serum of 100 patients with myasthenia gravis have been measured by 125I-RIA. The results showed that cAMP and cGMP were higher in the patients than in the controls significantly (P < 0.001). In 33 cases of these patients after using anticholinesterase drugs and prednisone, the levels of cAMP and cGMP reduced significantly. According to our study, we presumed that there would be cyclic nucleotide acid metabolic disturbances in patients with MG and cAMP might play a regulatory role in morbidity of MG.
Xu
J Z
JZ
Department of Neurology, Tongji Hospital, Tongji Medical University, Hubei.
D000242:Cyclic AMP / Q000097:blood*; D006152:Cyclic GMP / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D009157:Myasthenia Gravis / Q000097:blood* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use; D011729:Pyridostigmine Bromide / Q000627:therapeutic use
D000242:Cyclic AMP; D006152:Cyclic GMP; D011729:Pyridostigmine Bromide; D011241:Prednisone