[The effect of an altered hormonal background on the mother-fetus system on the development of the neuroglia].
The method of electron microscopy was used in studying the antero-parietal area of neonatal rats born from mothers treated by desoxycorticosterone-acetate (DOCA) during the last 7 days of gestation (II group) or last 14 days (III group). The animals of the III group were given greater doses of DOCA. The neocortex of experimental newborn rats had accelerated differentiation of glial elements: differentiating glioblasts and astroblasts were noted more frequently, while the III group of animals had in addition single cells looking like oligodendrogliocytes. Processes of differentiation of glioblasts were more pronounced in the III group of rats whose mothers were given greater doses of DOCA and during a longer period of time while processes of proliferation were more pronounced in the neocortex of newborn rats of the II group (mitosis figures most often).
Iurina
N A
NA
Pavlova
I G
IG
D000818:Animals; D000831:Animals, Newborn; D002454:Cell Differentiation / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects / Q000648:ultrastructure; D003900:Desoxycorticosterone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006706:Homeostasis / Q000187:drug effects*; D008854:Microscopy, Electron; D009024:Morphogenesis / Q000187:drug effects; D009457:Neuroglia / Q000187:drug effects* / Q000648:ultrastructure; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats
D003900:Desoxycorticosterone
Vliianie izmennogo gormonal'nogo fona v sisteme mat'--plod na razvitie neĭroglii.