title: Disseminated Pneumocystis carinii infection in a hemophiliac patient with acquired immunodeficiency syndrome.
abstract: A case of disseminated Pneumocystis carinii (PC) infection in a 28-year-old Japanese male hemophiliac with acquired immunodeficiency syndrome (AIDS) is reported. The patient had displayed a high fever and diffuse faint interstitial infiltrates on chest X-ray films without dyspnea three months before his death. At that time, no PC was detected after four consecutive induced sputum tests. Serum anti-cytomegalovirus (CMV) IgM was positive by EIA. No treatment for PC and CMV was given at the patient's request. Autopsy findings disclosed disseminated PC infection consisting of granulomas with caseation-like necrosis and frothy exudate in the lungs and disseminated organized calcification in the blood vessels of extrapulmonary organs. PC cysts and/or trophozoites were detected in these lesions.
authors.affiliation: Department of Pathology, University of Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Wakabayashi
authors.forename: S
authors.initials: S
authors.lastname: Oka
authors.forename: K
authors.initials: K
authors.lastname: Shimada
authors.forename: I
authors.initials: I
authors.lastname: Nakano
authors.forename: T
authors.initials: T
authors.lastname: Iwatsubo
authors.forename: S
authors.initials: S
authors.lastname: Mori
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000473:pathology; D000328:Adult; D002114:Calcinosis / Q000150:complications / Q000473:pathology; D003586:Cytomegalovirus Infections / Q000150:complications / Q000473:pathology; D016469:Fungemia / Q000150:complications / Q000473:pathology; D006099:Granuloma / Q000150:complications / Q000473:pathology; D006467:Hemophilia A / Q000150:complications* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D011020:Pneumonia, Pneumocystis / Q000150:complications / Q000473:pathology*; D013154:Spleen / Q000473:pathology