Proteolysis, proteasomes and antigen presentation.
Proteins presented to the immune system must first be cleaved to small peptides by intracellular proteinases. Proteasomes are proteolytic complexes that degrade cytosolic and nuclear proteins. These particles have been implicated in ATP-ubiquitin-dependent proteolysis and in the processing of intracellular antigens for cytolytic immune responses.
Goldberg
A L
AL
Department of Cellular and Molecular Physiology, Harvard Medical School, Boston, Massachusetts.
Rock
K L
KL
D000255:Adenosine Triphosphate / Q000378:metabolism / Q000494:pharmacology; D000938:Antigen-Presenting Cells / Q000276:immunology*; D000941:Antigens / Q000276:immunology / Q000378:metabolism*; D010450:Endopeptidases / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology; D014452:Ubiquitins / Q000494:pharmacology
D000941:Antigens; D011506:Proteins; D014452:Ubiquitins; D000255:Adenosine Triphosphate; D010450:Endopeptidases