title: Hypothyroidism associated with myeloid neoplasia. About 2 cases.
abstract: We report 2 cases of hypothyroidism in whom the associated haematological disturbances (macrocytic anaemia in both cases, mild leukopenia and thrombopenia in one patient) failed to be corrected by thyroid hormone replacement therapy. Further investigations led to the diagnosis of acute myeloid leukaemia (AML) in the first patient and myelodysplastic syndrome (MDS) in the other. The reasons of the delayed diagnosis and the possible mechanisms explaining this rare combination are discussed. The hypothesis of a purely coincidental association seems most likely.
authors.affiliation: Division of General Internal Medicine, Saint-Luc University Hospital, Brussels.
authors.forename: A L
authors.initials: AL
authors.lastname: Boonen
authors.forename: C
authors.initials: C
authors.lastname: Lefèbvre
authors.forename: M
authors.initials: M
authors.lastname: Lambert
authors.forename: A
authors.initials: A
authors.lastname: Ferrant
authors.forename: J L
authors.initials: JL
authors.lastname: Michaux
authors.forename: E
authors.initials: E
authors.lastname: Coche
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000748:Anemia, Macrocytic / Q000150:complications / Q000209:etiology; D000756:Anemia, Sideroblastic / Q000150:complications* / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000150:complications*; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged