[Study by in situ hybridization of the prevalence of herpes virus as cofactors of the tumoral development of papillomatous lesions of the anogenital region in seropositive and seronegative men against HIV].
Infection with specific types of HPV has emerged as necessary but not sufficient factor in the neoplastic transformation of anogenital condylomas. Some viruses (HIV, Herpes viridae: HSV, CMV, EBV) might act as cofactors in the neoplastic changes and cancer. To study the prevalence of these viral pathogens in anogenital lesions, biopsies were obtained from HIV seropositive or seronegative men and tested using in situ hybridization technique. Infection by "high risk" HPV, HSV and CMV are facilitated in patients immunocompromised by HIV. Presence of CMV is more frequent in high risk HPV-induced lesions than in low risk HPV lesions.
Bernard
C
C
Laboratoire de Virologie, CHU St-Jacques, Besançon.
Mougin
C
C
Rossel
M
M
Laurent
R
R
Lab
M
M
D001005:Anus Neoplasms / Q000209:etiology* / Q000382:microbiology; D003587:Cytomegalovirus; D005834:Genital Neoplasms, Male / Q000209:etiology* / Q000382:microbiology; D006679:HIV Seropositivity / Q000150:complications*; D006564:Herpesviridae; D004854:Herpesvirus 4, Human; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D027383:Papillomaviridae; D018139:Simplexvirus; D014412:Tumor Virus Infections / Q000150:complications*
Etude par hybridation in situ de la prévalence des Herpès virus comme cofacteurs de l'évolution tumorale des lésions papillomateuses du tractus anogénital chez des hommes sérologiquement positifs et négatifs vis-à-vis du HIV.