Influence of age on the induction of oral tolerance in mice and its adoptive transfer by spleen cells.
1. Seven-week-old B6D2F1 mice were highly susceptible to the induction of oral tolerance to ovalbumin (Ova), whereas 70-week-old mice were totally refractory. 2. Immune responsiveness (secondary antibody formation) to intraperitoneal immunization to Ova was the same in 7-week- or 70-week-old B6D2F1 mice. 3. In B6D2F1 mice, the adoptive transfer of spleen cells from old donors into young recipients hindered, and, reciprocally, transfer of spleen cells from young donors into old recipients facilitated the induction of oral tolerance. 4. In BALB/c mice, which are refractory to oral tolerance to Ova, the adoptive transfer of spleen cells from neonate or young donors into old recipients failed to modify the lack of susceptibility to the induction of oral tolerance.
Lahmann
W M
WM
Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Menezes
J S
JS
Verdolin
B A
BA
Vaz
N M
NM
D000375:Aging / Q000276:immunology*; D000818:Animals; D000906:Antibodies / Q000097:blood; D000918:Antibody Specificity / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007108:Immune Tolerance / Q000276:immunology*; D007114:Immunization / Q000379:methods; D016219:Immunotherapy, Adoptive; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009055:Mouth / Q000276:immunology*; D010047:Ovalbumin / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000276:immunology*
D000906:Antibodies; D010047:Ovalbumin