title: Prognostic significance of tumor deoxyribonucleic acid content in surgically resected small-cell carcinoma of lung.
abstract: The prognostic role of deoxyribonucleic acid flow cytometry was investigated in 53 cases of surgically resected small-cell lung cancer. Deoxyribonucleic acid aneuploidy was detected in 26 patients (49.1%), the remaining tumors being either diploid or tetraploid. Patients with aneuploid tumors had a significantly reduced 2-year survival (38.5%) when compared with patients with diploid or tetraploid tumors (70.3%; p less than 0.05). This finding was independent of tumor stage on multiple logistic regression analysis. Diploid or tetraploid deoxyribonucleic acid content was associated with a particularly good 2-year survival (85%) in N0 or N1 disease. Tumor deoxyribonucleic acid ploidy should be taken into account in planning of management and assessment of prognosis in small-cell lung cancer.
authors.affiliation: Department of Pathology, University of Edinburgh, United Kingdom.
authors.forename: F A
authors.initials: FA
authors.lastname: Carey
authors.forename: U S
authors.initials: US
authors.lastname: Prasad
authors.forename: W S
authors.initials: WS
authors.lastname: Walker
authors.forename: E W
authors.initials: EW
authors.lastname: Cameron
authors.forename: D
authors.initials: D
authors.lastname: Lamb
authors.forename: C C
authors.initials: CC
authors.lastname: Bird
mesh_terms: D018288:Carcinoma, Small Cell / Q000737:chemistry / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D004273:DNA, Neoplasm / Q000032:analysis*; D005434:Flow Cytometry; D006801:Humans; D008175:Lung Neoplasms / Q000737:chemistry / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D008207:Lymphatic Metastasis; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011003:Ploidies; D011013:Pneumonectomy; D011379:Prognosis
chemical_list: D004273:DNA, Neoplasm