title: Blood pressure response to acute changes in dietary sodium in young Zimbabwean men.
abstract: OBJECTIVE
  The primary objective of this study was to determine the effect of acute alterations in sodium intake upon the blood pressure and hormone levels of young Zimbabwean men.
  
  
  METHODS
  Blood pressure, 24-h urinary electrolyte excretion and plasma concentrations of angiotensin II, aldosterone, and atrial natriuretic peptide were measured in normotensive black medical students. Three sets of measurements were taken: (1) during free access to sodium (baseline); (2) after 4 days on a low-sodium diet (10 mmol/day); and (3) after 4 days on a high-sodium diet (800 mmol/day).
  
  
  METHODS
  Blood pressure was measured by random zero sphygmomanometry, hormone levels by radioimmunoassay, and urinary electrolytes by flame photometry.
  
  
  RESULTS
  The low-sodium diet caused the range of pulse pressure to narrow, with a decrease in systolic blood pressure (SBP) and an increase in diastolic blood pressure (DBP). With the introduction of the high-sodium diet, SBP increased and DBP decreased. Mean arterial pressure did not change. At the same time, angiotensin II and aldosterone decreased. Plasma atrial natriuretic peptide did not change. A subgroup of the men on the high-sodium diet also received 100 mmol potassium/day. The increase in SBP associated with high sodium was significantly attenuated by the presence of added potassium.
  
  
  CONCLUSIONS
  SBP of young black Zimbabwean men is lowered by dietary sodium restriction and rises with a large increase in dietary sodium for a short duration, but mean arterial pressure does not change due to the opposing decreases in DBP.
authors.affiliation: University of Zimbabwe, Harare.
authors.forename: J
authors.initials: J
authors.lastname: Mufunda
authors.forename: J E
authors.initials: JE
authors.lastname: Chimoskey
authors.forename: J
authors.initials: J
authors.lastname: Matenga
authors.forename: C
authors.initials: C
authors.lastname: Musabayane
authors.forename: H V
authors.initials: HV
authors.lastname: Sparks
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood; D000704:Analysis of Variance; D000804:Angiotensin II / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D003971:Diastole / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004573:Electrolytes / Q000097:blood; D006801:Humans; D008297:Male; D012016:Reference Values; D012982:Sodium, Dietary / Q000008:administration & dosage*; D013599:Systole / Q000187:drug effects / Q000502:physiology; D015030:Zimbabwe
chemical_list: D004573:Electrolytes; D012982:Sodium, Dietary; D000804:Angiotensin II; D000450:Aldosterone; D009320:Atrial Natriuretic Factor