Leukotriene receptors in the skin of rats differ from those of mouse skin or rat stomach strip.
To compare the receptors for cysteinyl-leukotriene (cys-LT) in rat skin with those in other tissues, we investigated the effects of specific cys-LT receptor antagonists (FPL 55712, LY171883, MCI-826 and L-648051) on cys-LT-induced cutaneous reactions in rats and mice, and on cys-LT-induced contractile responses in rat stomach smooth muscle. We also studied the effects of these drugs on homologous passive cutaneous anaphylaxis. The four cys-LT receptor antagonists dose dependently inhibited cys-LT-induced cutaneous reactions in mouse ear, but failed to inhibit passive cutaneous anaphylaxis and the histamine-induced cutaneous reaction. In rats, only MCI-826 inhibited cys-LT-induced cutaneous reactions although the other three drugs failed to inhibit these reactions. In contrast, the cys-LT-induced contractile responses of rat stomach smooth muscle were inhibited by all these drugs in a concentration-dependent manner. These results suggest that cys-LT receptors in rat skin have an affinity different from that of receptors in mouse skin and rat stomach. They also suggest that cys-LTs are not involved in passive cutaneous anaphylaxis in mice and rats.
Miura
T
T
Department of Pharmacology, Gifu Pharmaceutical University, Japan.
Inagaki
N
N
Goto
S
S
Yoshida
K
K
Nagai
H
H
Koda
A
A
D000098:Acetophenones / Q000494:pharmacology; D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D009119:Muscle Contraction / Q000187:drug effects; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D011971:Receptors, Immunologic / Q000032:analysis / Q000187:drug effects*; D018077:Receptors, Leukotriene; D013189:SRS-A / Q000494:pharmacology; D012867:Skin / Q000737:chemistry*; D013045:Species Specificity; D013270:Stomach / Q000737:chemistry / Q000187:drug effects* / Q000502:physiology; D013777:Tetrazoles / Q000494:pharmacology; D013844:Thiazoles / Q000494:pharmacology
D000098:Acetophenones; D011971:Receptors, Immunologic; D018077:Receptors, Leukotriene; D013189:SRS-A; D013777:Tetrazoles; D013844:Thiazoles; C077265:MCI 826; C044660:LY 171883