Avian retroviral recombinant expressing foreign envelope delays tumour formation of ASV-A-induced sarcoma.
An avian recombinant retrovirus expressing subgroup A envelope glycoprotein antigenicity, RAV-0-A1, significantly delayed sarcoma induction in chickens after challenge with ASV-A. When tumours were formed, significantly smaller tumours resulted. The mechanism of protection does not appear to be interference mediated, since virus was not detected in the chickens. Protection was correlated with both neutralizing and complement-dependent cytotoxic antibodies (CDCA).
Wright
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Viral Oncology Laboratory, VA Medical Center, Salt Lake City, UT.
Bennett
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D000375:Aging / Q000502:physiology; D000818:Animals; D001358:Avian Sarcoma Viruses / Q000235:genetics / Q000276:immunology*; D002645:Chickens; D007114:Immunization; D001357:Sarcoma, Avian / Q000382:microbiology / Q000517:prevention & control*; D014614:Vaccines, Synthetic / Q000235:genetics / Q000627:therapeutic use*; D014759:Viral Envelope Proteins / Q000235:genetics / Q000276:immunology*; D014765:Viral Vaccines / Q000627:therapeutic use*
D014614:Vaccines, Synthetic; D014759:Viral Envelope Proteins; D014765:Viral Vaccines