title: Oxidative stress and ageing in the fungus Podospora anserina.
abstract: The ageing phenomenon exhibited by the ascomycetous fungus Podospora anserina can be either delayed or induced by either different carbon sources or effectors. As these effects seem to have analogy to catabolite-repression of respiratory genes, experiments concerning respiratory functions have been carried out. Ageing is parallelled by switching from cytochrome c-oxidase-mediated respiration to alternative, cyanide-resistant respiration for reasons still unknown. The latter is always accompanied by appearance of the phenol oxidizing enzyme laccase (EC 1.10.3.2), which seems to act as an alternative oxidase. The existence of a second, non-mitochondrially encoded respiratory pathway relieves the selective pressure on mitochondria leading to disintegrated, non-functional mtDNA and thereby whole mitochondria which accumulate in the hyphal cells. Mutants lacking cytochrome c-oxidase aa3 or laccase have stable mitochondrial populations and live eternally.
authors.affiliation: Berlin University of Technology, Dept. Microbiology and Genetics, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Frese
authors.forename: U
authors.initials: U
authors.lastname: Stahl
mesh_terms: D004272:DNA, Mitochondrial / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000502:physiology; D005658:Fungi / Q000378:metabolism / Q000502:physiology*; D042845:Laccase; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism*; D010088:Oxidoreductases / Q000502:physiology; D010101:Oxygen Consumption
chemical_list: D004272:DNA, Mitochondrial; D010088:Oxidoreductases; D042845:Laccase; D003576:Electron Transport Complex IV