title: CD28 receptor crosslinking induces tyrosine phosphorylation of PLC gamma 1.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121.
authors.forename: J A
authors.initials: JA
authors.lastname: Ledbetter
authors.forename: P S
authors.initials: PS
authors.lastname: Linsley
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D015703:Antigens, CD / Q000502:physiology*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000502:physiology*; D016227:Benzoquinones; D018106:CD28 Antigens; D016466:CHO Cells; D002478:Cells, Cultured; D006224:Cricetinae; D004789:Enzyme Activation; D005786:Gene Expression Regulation; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis; D047029:Lactams, Macrocyclic; D008213:Lymphocyte Activation; D043265:Phosphatidylinositol Diacylglycerol-Lyase; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D010766:Phosphorylation; D010835:Phytohemagglutinins / Q000494:pharmacology; D011499:Protein Processing, Post-Translational; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D011809:Quinones / Q000494:pharmacology; D011940:Receptor Aggregation; D017828:Rifabutin / Q000031:analogs & derivatives; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D016227:Benzoquinones; D018106:CD28 Antigens; D007376:Interleukin-2; D047029:Lactams, Macrocyclic; D010835:Phytohemagglutinins; D011809:Quinones; D017828:Rifabutin; C020754:herbimycin; D011505:Protein-Tyrosine Kinases; D010727:Phosphoric Diester Hydrolases; D043265:Phosphatidylinositol Diacylglycerol-Lyase