title: Properties of the guinea-pig lung platelet-activating factor receptor encoded by the cloned cDNA.
abstract: Platelet-activating factor (PAF) is a naturally occurring phospholipid possessing proinflammatory and shock-inducing activities. Although PAF exerts these functions via specific receptors, the molecular structures of the receptor has not been clarified. We have isolated a cDNA coding for PAF receptor through expression cloning. The PAF receptor expressed in Xenopus laevis oocytes and COS-7 cells showed pharmacological properties consistent with those in previous reports. Sequence analysis revealed that PAF receptor belongs to the superfamily of G-protein-coupled receptors.
authors.affiliation: Department of Physiological Chemistry and Nutrition, Faculty of Medicine, University of Tokyo, Japan.
authors.forename: Z
authors.initials: Z
authors.lastname: Honda
authors.forename: M
authors.initials: M
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Seyama
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
mesh_terms: D000818:Animals; D002460:Cell Line; D003001:Cloning, Molecular; D004247:DNA; D019204:GTP-Binding Proteins / Q000378:metabolism; D006168:Guinea Pigs; D008168:Lung / Q000378:metabolism*; D010972:Platelet Activating Factor / Q000378:metabolism*; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled; D014982:Xenopus laevis
chemical_list: D010972:Platelet Activating Factor; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; C039351:platelet activating factor receptor; D004247:DNA; D019204:GTP-Binding Proteins