Negative inotropic and chronotropic activity of calcium channel ligands possessing a xanthone 1,4-dihydropyridine backbone.
A series of xanthone 1,4-dihydropyridine derivatives were prepared. The compounds were evaluated for inotropic, chronotropic, and calcium antagonist properties.
Chiarini
A
A
Department of Pharmaceutical Sciences, University of Bologna, Italy.
Rampa
A
A
Bisi
A
A
Budriesi
R
R
Valenti
P
P
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D015220:Calcium Channels / Q000187:drug effects*; D003864:Depression, Chemical; D004095:Dihydropyridines / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D008024:Ligands; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects*; D013268:Stimulation, Chemical; D014966:Xanthenes / Q000494:pharmacology*
D015220:Calcium Channels; D004095:Dihydropyridines; D008024:Ligands; D014966:Xanthenes