title: Hepatic angiomyolipomas with a deceptive trabecular pattern and HMB-45 reactivity.
abstract: We report two cases of giant hepatic angiomyolipoma with a prominent component of epithelioid smooth muscle cells exhibiting a distinctive trabecular arrangement. These cells possessed peripherally vacuolated and centrally condensed hyaline cytoplasm. The nuclei were eccentrically placed in the cytoplasm. Immunohistochemically, they expressed HMB-45 intensely in the central condensed cytoplasm and actin in a perimembranous fashion. Staining for desmin, myoglobin and vimentin was negative. HMB-45 may prove to be a sensitive marker for angiomyolipoma with epithelioid cells. Hepatocellular carcinoma and other hepatic tumours with polygonal clear cells can be readily distinguished by these means.
authors.affiliation: Institute of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong.
authors.forename: W M
authors.initials: WM
authors.lastname: Tsui
authors.forename: A K
authors.initials: AK
authors.lastname: Yuen
authors.forename: K F
authors.initials: KF
authors.lastname: Ma
authors.forename: C C
authors.initials: CC
authors.lastname: Tse
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal; D015415:Biomarkers; D006528:Carcinoma, Hepatocellular / Q000737:chemistry / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006391:Hemangioma / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008067:Lipoma / Q000737:chemistry / Q000473:pathology*; D008113:Liver Neoplasms / Q000737:chemistry / Q000473:pathology*; D008875:Middle Aged
chemical_list: D000911:Antibodies, Monoclonal; D015415:Biomarkers