Sinonasal Schneiderian papillomas: human papillomavirus typing by polymerase chain reaction.
A series of 35 formalin-fixed, paraffin-embedded Schneiderian papillomas (24 inverted, nine cylindrical cell type, and two fungiform) of the nasal cavity were evaluated for the presence of human papillomavirus (HPV) types 6b/11, 16, and 18 DNA sequences using both a highly sensitive and specific modification of the polymerase chain reaction technique and conventional in situ hybridization. The HPV gene sequences (E6-E7 portions) were not detected in any of the 24 inverted or nine cylindrical cell papillomas. One of the fungiform papillomas was positive for HPV 6b/11. We conclude: (a) the origin of most Schneiderian sinonasal papillomas is not associated with HPV infection of these common types, and (b) fungiform papilloma is a distinctive clinicopathologic subtype of Schneiderian papilloma that may be HPV-related.
Sarkar
F H
FH
Department of Pathology, Wayne State University, School of Medicine, Detroit, Michigan.
Visscher
D W
DW
Kintanar
E B
EB
Zarbo
R J
RJ
Crissman
J D
JD
D001483:Base Sequence; D015344:DNA Probes, HPV; D004279:DNA, Viral / Q000737:chemistry*; D006801:Humans; D008969:Molecular Sequence Data; D009300:Nasal Septum; D009669:Nose Neoplasms / Q000382:microbiology* / Q000473:pathology; D010212:Papilloma / Q000382:microbiology* / Q000473:pathology; D027383:Papillomaviridae / Q000145:classification* / Q000302:isolation & purification; D010255:Paranasal Sinus Neoplasms / Q000382:microbiology / Q000473:pathology; D016133:Polymerase Chain Reaction
D015344:DNA Probes, HPV; D004279:DNA, Viral