title: In vitro susceptibility of avian Escherichia coli and Pasteurella multocida to danofloxacin and five other antimicrobials.
abstract: The in vitro susceptibility of Escherichia coli and Pasteurella multocida isolated from poultry was determined to danofloxacin, a novel fluoroquinolone, and five other commonly used antimicrobials. A total of 1737 E. coli field isolates and 107 P. multocida isolates were tested by veterinary diagnostic laboratories in Europe, Japan, South Africa, and North America during the period 1989-91. The antimicrobial susceptibility of these isolates was determined using the Sensititre broth microdilution technique. The minimum inhibitory concentrations (MIC) of danofloxacin, furaltadone, lincomycin, oxytetracycline, spectinomycin, and trimethoprim:sulfamethoxazole that prevented growth of 90% of the bacteria were 0.25 > 64, > 64, > 64, > 128, and > 16 micrograms/ml, respectively, against E. coli isolates and 0.25, 64, 64, 16, 128, and 8 micrograms/ml, respectively, against P. multocida isolates. Danofloxacin demonstrated considerable in vitro potency against these important poultry pathogens, many of which showed extensive resistance to the other antimicrobials tested.
authors.affiliation: Animal Health Group, Pfizer Inc., New York, New York 10017-5755.
authors.forename: D L
authors.initials: DL
authors.lastname: Raemdonck
authors.forename: A C
authors.initials: AC
authors.lastname: Tanner
authors.forename: S T
authors.initials: ST
authors.lastname: Tolling
authors.forename: S L
authors.initials: SL
authors.lastname: Michener
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002645:Chickens / Q000382:microbiology*; D004926:Escherichia coli / Q000187:drug effects*; D024841:Fluoroquinolones; D008826:Microbial Sensitivity Tests / Q000662:veterinary; D016979:Pasteurella multocida / Q000187:drug effects*; D011201:Poultry Diseases / Q000188:drug therapy / Q000382:microbiology; D015363:Quinolones / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D015363:Quinolones; C068581:danofloxacin