title: Ubiquitin-positive intraneuronal inclusions in the extramotor cortices of presenile dementia patients with motor neuron disease.
abstract: Ubiquitin-positive intraneuronal inclusions were found in the extramotor cortices of ten presenile dementia patients with motor neuron disease. There were inclusions in the hippocampal granular cells and in the small neurons of the superficial layers of the temporal and frontal cortices. Bunina bodies were present in the anterior horn cells in all cases. These results suggest that ubiquitin-related cytoskeletal abnormalities are common in cerebral non-motor small neurons in these patients.
authors.affiliation: Department of Neurology, Gunma University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Okamoto
authors.forename: N
authors.initials: N
authors.lastname: Murakami
authors.forename: H
authors.initials: H
authors.lastname: Kusaka
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: Y
authors.initials: Y
authors.lastname: Hashizume
authors.forename: Y
authors.initials: Y
authors.lastname: Nakazato
authors.forename: E
authors.initials: E
authors.lastname: Matsubara
authors.forename: S
authors.initials: S
authors.lastname: Hirai
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000378:metabolism*; D003704:Dementia / Q000150:complications / Q000378:metabolism*; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000150:complications / Q000378:metabolism*; D009474:Neurons / Q000737:chemistry*; D014452:Ubiquitins / Q000032:analysis*
chemical_list: D014452:Ubiquitins