Regulation of TCR alpha and beta gene allelic exclusion during T-cell development.
Early in their development, most T cells become committed to the expression of one, and only one, TCR alpha beta combination. How do T cells achieve this TCR allelic exclusion? This article discusses the configuration and expression of TCR alpha and beta genes in mature T-cell lines and TCR alpha beta transgenic mice, and proposes three nonexclusive models to account for the significant occurrence of T cells with two productive alpha gene rearrangements.
Malissen
M
M
Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, France.
Trucy
J
J
Jouvin-Marche
E
E
Cazenave
P A
PA
Scollay
R
R
Malissen
B
B
D000483:Alleles; D000818:Animals; D002999:Clone Cells; D004254:DNA Nucleotidyltransferases / Q000235:genetics; D005786:Gene Expression Regulation; D015332:Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor / Q000235:genetics; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*; D013601:T-Lymphocytes / Q000276:immunology*; D045567:VDJ Recombinases
D016693:Receptors, Antigen, T-Cell, alpha-beta; D004254:DNA Nucleotidyltransferases; D045567:VDJ Recombinases