[The effect of the delta sleep-inducing peptide on seizure activity].
The delta-sleep-inducing peptide (DSIP) suppressed seizure activity in the cat cortical strychnine-induced seizure foci. The DSIP delayed development of corazol kindling in rats, prevented seizure induced with bicucullin and other agents in mice. The DSIP effect was shown to be realised through the action upon reticular black substance. The DSIP seems to take part in endogenous control of the brain excitability.
SHandra
A A
AA
Godlevskiĭ
L S
LS
Mazarati
A M
AM
Oleshko
A A
AA
Mikhaleva
I I
II
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002415:Cats; D003701:Delta Sleep-Inducing Peptide / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004569:Electroencephalography / Q000187:drug effects; D007696:Kindling, Neurologic / Q000187:drug effects / Q000502:physiology; D008297:Male; D008636:Mesencephalon / Q000737:chemistry / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D013997:Time Factors
D003701:Delta Sleep-Inducing Peptide
Vliianie del'ta-son-indutsiruiushchego peptida na sudorozhnuiu aktivnost'.