title: Human choline acetyltransferase (CHAT): partial gene sequence and potential control regions.
abstract: Choline acetyltransferase (CHAT) (EC 2.3.1.6) is the biosynthetic enzyme for the neurotransmitter acetylcholine in the central and peripheral nervous systems. In this study, a human CHAT genomic clone has been isolated and partially sequenced at its 5' end. This fragment contains the first four exons with an ACG initiator codon and potential control regions including TATA, CAAT, GC boxes, and several transcription control sequences. A comparison of the primary structure of CHAT among pig, rat, mouse, and Drosophila is presented.
authors.affiliation: Institut de Chimie Biologique, Faculté de Médecine, Strasbourg, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Toussaint
authors.forename: V
authors.initials: V
authors.lastname: Geoffroy
authors.forename: M
authors.initials: M
authors.lastname: Schmitt
authors.forename: A
authors.initials: A
authors.lastname: Werner
authors.forename: J M
authors.initials: JM
authors.lastname: Garnier
authors.forename: P
authors.initials: P
authors.lastname: Simoni
authors.forename: J
authors.initials: J
authors.lastname: Kempf
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002795:Choline O-Acetyltransferase / Q000235:genetics*; D004247:DNA / Q000235:genetics; D004330:Drosophila; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D051381:Rats; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D013552:Swine
chemical_list: D004247:DNA; D002795:Choline O-Acetyltransferase