title: Functions of cytochrome c in regulation of electron transfer and protein folding.
abstract: Cytochrome c, a "mobile electron carrier" of the mitochondrial respiratory chain, also occurs in detectable amounts in the cytosol, and can receive electrons from cytochromes present in endoplasmic reticulum and plasma membranes as well as from superoxide and ascorbate. The pigment was found to dissociate from mitochondrial membranes in liver and kidney when rats were subjected to heat exposure and starvation, respectively. Treating cytochrome c with hydroxylamine gives a partially deaminated product with altered redox properties; decreased stimulation of respiration by deficient mitochondria, increased reduction by superoxide, and complete loss of reducibility by plasma membranes. Mitochondria isolated from brown adipose tissue of cold-exposed rats are found to be sub-saturated with cytochrome c. The ability of cytochrome c to reactivate reduced ribonuclease is now reinterpreted as a molecular chaperone role for the hemoprotein.
authors.affiliation: Department of Biochemistry, Indian Institute of Science, Bangalore.
authors.forename: T
authors.initials: T
authors.lastname: Ramasarma
authors.forename: B K
authors.initials: BK
authors.lastname: Rasheed
authors.forename: S
authors.initials: S
authors.lastname: Vijaya
authors.forename: R S
authors.initials: RS
authors.lastname: Puranam
authors.forename: V
authors.initials: V
authors.lastname: Shivaswamy
authors.forename: A S
authors.initials: AS
authors.lastname: Gaikwad
authors.forename: C K
authors.initials: CK
authors.lastname: Kurup
mesh_terms: D000818:Animals; D003574:Cytochrome c Group / Q000737:chemistry / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism; D004579:Electron Transport; D007668:Kidney / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism; D008954:Models, Biological; D011487:Protein Conformation; D013347:Subcellular Fractions / Q000378:metabolism
chemical_list: D003574:Cytochrome c Group