Encephalomyocarditis (EMC) virus-induced myocarditis by different virus variants and mouse strains.
The mode of occurrence of encephalomyocarditis (EMC) virus-induced myocarditis in mice was pathologically and virologically investigated using 2 virus variants (highly diabetogenic EMC-D and non-diabetogenic EMC-B) and 2 mouse strains (diabetes-susceptible BALB/c and diabetes-resistant C57BL/6). Mice were inoculated with 10(5) PFU/head of the virus intraperitoneally and observed up to 7 days post inoculation (7DPI). As compared with EMC-B-infected BALB/c and EMC-D-infected C57BL/6 mice, EMC-D-infected BALB/c mice developed marked myocarditis and exhibited a heart virus titer of more than 100 times above that of the others after 4DPI. Electron microscopically, small aggregations of virus-like particles, with 20-25 nm in diameter, were found in the cytoplasm of degenerated cardiomyocytes showing mitochondrial and myofibrillar degeneration in EMC-D-infected BALB/c mice.
Hirasawa
K
K
Department of Biomedical Science, Faculty of Agriculture, University of Tokyo, Japan.
Han
J S
JS
Takeda
M
M
Itagaki
S
S
Doi
K
K
D000818:Animals; D004686:Encephalomyocarditis virus; D004769:Enterovirus Infections / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D006943:Hyperglycemia / Q000382:microbiology / Q000662:veterinary; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008854:Microscopy, Electron / Q000662:veterinary; D009205:Myocarditis / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D012376:Rodent Diseases / Q000097:blood / Q000382:microbiology* / Q000473:pathology; D013045:Species Specificity