title: The role of standard-dose etoposide in the management of non-small cell lung cancer.
abstract: Etoposide remains an integral component of therapy for non-small cell lung cancer. Its single-agent activity, and, hence, its activity in combination therapy, need to be reassessed in light of several reports of increased activity at higher doses. Although no effective means of overcoming resistance to etoposide appear to exist, topoisomerase II levels may predict sensitivity to treatment. Biologic response modifiers appear to add little or nothing to standard etoposide chemotherapy for non-small cell lung cancer. Continuous low-dose etoposide infusions do not appear to exhibit the same degree of activity as has been observed with prolonged oral dosing. The availability of effective means of reducing hematologic and emetic side effects of chemotherapy may permit rational trials of more intensive therapy.
authors.affiliation: H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa 33612.
authors.forename: J C
authors.initials: JC
authors.lastname: Ruckdeschel
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000556:secondary / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D004334:Drug Administration Schedule; D005047:Etoposide / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000628:therapy
chemical_list: D005047:Etoposide