Abnormalities in Na+/H+ antiporter activity in diabetic nephropathy.
In hypertensive humans and the spontaneously hypertensive rat, increased cellular Na+/H+ antiport activity has been demonstrated in leukocytes, platelets, skeletal muscle, and vascular smooth muscle cells. This membrane abnormality may be associated with medial thickening of resistance vessels. A similar membrane transport abnormality has also been demonstrated in leukocytes and fibroblasts from type 1 diabetic patients with nephropathy. This membrane transport marker of hypertension may indicate a predisposition to essential hypertension in such patients and may lead to diabetic nephropathy, possibly from mesangial expansion.
Ng
L L
LL
Department of Pharmacology, Leicester Royal Infirmary, United Kingdom.
Davies
J E
JE
D015415:Biomarkers; D002352:Carrier Proteins / Q000378:metabolism*; D003928:Diabetic Nephropathies / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000378:metabolism; D066298:In Vitro Techniques; D017136:Ion Transport; D011499:Protein Processing, Post-Translational; D011522:Protons; D012964:Sodium / Q000378:metabolism*; D017923:Sodium-Hydrogen Exchangers
D015415:Biomarkers; D002352:Carrier Proteins; D011522:Protons; D017923:Sodium-Hydrogen Exchangers; D012964:Sodium