A brief review of the Ah locus.
The Ah locus, first described as a functional polymorphism among inbred strains of mice, encodes the Ah receptor--a ligand dependent transcriptional activator. This paper reviews the work on the Ah receptor and its importance in the expression of cytochrome P-450IA1 and the pleiotropic effects of halogenated aromatic hydrocarbons.
Poland
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A
McArdle Laboratory for Cancer Research, University of Wisconsin, Madison.
Bradfield
C
C
D000818:Animals; D002874:Chromosome Mapping / Q000379:methods; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D006846:Hydrocarbons, Halogenated / Q000494:pharmacology; D011083:Polycyclic Compounds / Q000494:pharmacology; D011110:Polymorphism, Genetic; D018336:Receptors, Aryl Hydrocarbon; D011955:Receptors, Drug / Q000235:genetics* / Q000378:metabolism*
D006846:Hydrocarbons, Halogenated; D011083:Polycyclic Compounds; D018336:Receptors, Aryl Hydrocarbon; D011955:Receptors, Drug; D003577:Cytochrome P-450 Enzyme System