title: Lack of association between cytomegalovirus infection, HLA matching and the vanishing bile duct syndrome after liver transplantation.
abstract: In this study we evaluated the association between cytomegalovirus infection alone or in relation to human leukocyte antigen matching and the development of vanishing bile duct syndrome, a form of chronic hepatic allograft rejection. A total of 81 consecutive liver transplant recipients were studied. Cytomegalovirus infection developed in 46 recipients (57%), and vanishing bile duct syndrome occurred in 9 recipients (11%). Cytomegalovirus infection developed in only five of the nine patients with vanishing bile duct syndrome. Univariate analysis of pretransplant recipient/donor cytomegalovirus serological tests and human leukocyte antigen typing showed they were not significant risk factors for the development of vanishing bile duct syndrome. Time-dependent analysis of cytomegalovirus infection after transplantation as a risk factor for vanishing bile duct syndrome, in a multivariate analysis with human leukocyte antigen match, showed no statistical significance. In our study, no association was found between cytomegalovirus infection alone or in relation to class I or II human leukocyte antigen match and the subsequent development of vanishing bile duct syndrome.
authors.affiliation: Division of Infectious Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905.
authors.forename: C V
authors.initials: CV
authors.lastname: Paya
authors.forename: R H
authors.initials: RH
authors.lastname: Wiesner
authors.forename: P E
authors.initials: PE
authors.lastname: Hermans
authors.forename: J J
authors.initials: JJ
authors.lastname: Larson-Keller
authors.forename: D M
authors.initials: DM
authors.lastname: Ilstrup
authors.forename: R A
authors.initials: RA
authors.lastname: Krom
authors.forename: S B
authors.initials: SB
authors.lastname: Moore
authors.forename: J
authors.initials: J
authors.lastname: Ludwig
authors.forename: T F
authors.initials: TF
authors.lastname: Smith
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D000704:Analysis of Variance; D001649:Bile Duct Diseases / Q000150:complications*; D003586:Cytomegalovirus Infections / Q000209:etiology / Q000276:immunology / Q000503:physiopathology*; D005260:Female; D006650:Histocompatibility Testing; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D016031:Liver Transplantation / Q000276:immunology; D008297:Male; D016016:Proportional Hazards Models; D012307:Risk Factors; D013577:Syndrome; D013997:Time Factors
chemical_list: D000212:Acyclovir