title: Impaired microcirculation in mild-to-moderate essential arterial hypertension.
abstract: OBJECTIVE
  The aim of this study was to correlate capillary morphology and erythrocyte velocity to blood pressure in mild-to-moderate essential arterial hypertension.
  
  
  METHODS
  Ambulatory blood pressure measurement may provide more precise information about a patient's mean blood pressure than office measurements.
  
  
  METHODS
  Fifteen patients with recently diagnosed, previously untreated mild-to-moderate essential hypertension underwent 24-h ambulatory blood pressure recording and a capillaroscopic examination of finger microcirculation. Erythrocyte velocity was determined by the flying spot technique.
  
  
  RESULTS
  Both mean 24-h ambulatory systolic blood pressure (SBP) and mean 24-h ambulatory diastolic blood pressure (DBP) were significantly inversely correlated with capillary erythrocyte velocity. However, the correlation between erythrocyte velocity and office SBP and office DBP was less significant. Capillary length was related to 24-h ambulatory DBP but not to office DBP. Capillary number was not related to any blood pressure parameter.
  
  
  CONCLUSIONS
  These results indicate that, in patients with mild-to-moderate essential hypertension, erythrocyte velocity is significantly lower than for matched controls. It is also inversely related to mean 24-h ambulatory SBP and 24-h ambulatory DBP.
authors.affiliation: Department of Cardiology and Angiology, University Hospital, Gent, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: Duprez
authors.forename: M
authors.initials: M
authors.lastname: De Buyzere
authors.forename: T
authors.initials: T
authors.lastname: De Backer
authors.forename: J
authors.initials: J
authors.lastname: Vercammen
authors.forename: F
authors.initials: F
authors.lastname: Brusselmans
authors.forename: D L
authors.initials: DL
authors.lastname: Clement
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D015924:Blood Pressure Monitors; D002196:Capillaries / Q000503:physiopathology; D004912:Erythrocytes / Q000502:physiology; D005260:Female; D005385:Fingers / Q000098:blood supply*; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009262:Nails / Q000098:blood supply; D012044:Regression Analysis