Hydroxyl radical generation from heart mitochondria damaged by ischemia.
The hydroxyl radicals are known to be a biologically active oxygen species. A remarkable enhancement of hydroxyl radical generation was observed in the mitochondria obtained from ischemic myocardium. The hydroxyl radicals are the primary reactive species leading to cellular damages, such as membrane damages, DNA damages, enzyme inactivation, protein denaturation and so forth. The origin of the hydroxyl radicals appeared in mitochondria was discussed.
Ogura
R
R
Department of Medical Biochemistry, Kurume University School of Medicine, Japan.
D000818:Animals; D004578:Electron Spin Resonance Spectroscopy; D004579:Electron Transport / Q000502:physiology; D005609:Free Radicals; D006878:Hydroxides / Q000378:metabolism*; D017665:Hydroxyl Radical; D066298:In Vitro Techniques; D008929:Mitochondria, Heart / Q000378:metabolism* / Q000473:pathology; D017202:Myocardial Ischemia / Q000378:metabolism* / Q000473:pathology; D051381:Rats
D005609:Free Radicals; D006878:Hydroxides; D017665:Hydroxyl Radical