title: Correlation of serum metalloproteinase levels with lung cancer metastasis and response to therapy.
abstract: Cancer cells elaborate metalloproteinases which may play a role in invasion and metastasis. The serum level of the M(r) 72,000 type IV collagenase (MMP-2) was measured in 87 lung cancer patients. Stage IV cancer levels were significantly elevated (P less than 0.0001) compared to normal sera. A significant difference (P less than 0.01) was found between enzyme levels in the presence versus the absence of distant metastasis. For 29 patients treated with combination chemotherapy, a positive relationship was noted between response failure and elevated enzyme levels. Serum metalloproteinase levels may provide information relevant to prognosis as well as treatment decisions.
authors.affiliation: Histology Institute, Padova University, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Garbisa
authors.forename: G
authors.initials: G
authors.lastname: Scagliotti
authors.forename: L
authors.initials: L
authors.lastname: Masiero
authors.forename: C
authors.initials: C
authors.lastname: Di Francesco
authors.forename: C
authors.initials: C
authors.lastname: Caenazzo
authors.forename: M
authors.initials: M
authors.lastname: Onisto
authors.forename: M
authors.initials: M
authors.lastname: Micela
authors.forename: W G
authors.initials: WG
authors.lastname: Stetler-Stevenson
authors.forename: L A
authors.initials: LA
authors.lastname: Liotta
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D018288:Carcinoma, Small Cell / Q000097:blood / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology; D020780:Matrix Metalloproteinase 9; D003012:Microbial Collagenase / Q000097:blood*; D009362:Neoplasm Metastasis
chemical_list: D014408:Biomarkers, Tumor; D003012:Microbial Collagenase; D020780:Matrix Metalloproteinase 9