Role of NK-2 receptors in the antidipsogenic activity of neurokinins in the mouse.
1. The receptors involved in the anti-dipsogenic activity of neurokinin (NK) agonists were investigated in water-deprived mice. 2. Intracerebral administration of agonists selective at all three NK receptors (NK-1, NK-2, NK-3) caused inhibition of drinking in this model. However, only the NK-2 receptor agonist, GR64349, inhibited drinking without producing other behavioural effects. Both NK-1 (GR73632) and NK-3 (senktide) agonists induced a variety of behavioural effects which appeared to compete with the drinking response. 3. The inhibitory effect on drinking observed after central injection of the NK-2 agonist, GR64349, was attenuated by co-administration of the NK-2 antagonist, L-659,877, but not by the NK-1 antagonist, GR82334. 4. These results illustrate that the antidipsogenic activity of the NKs, in mice, is mediated via NK-2 receptors.
Walsh
D M
DM
Neuropharmacology Department, Glaxo Group Research Ltd, Ware, England.
Elliott
P J
PJ
Hagan
R M
RM
D000818:Animals; D004326:Drinking / Q000187:drug effects*; D007276:Injections, Intraventricular; D007705:Kinins / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D018041:Receptors, Neurokinin-2; D017981:Receptors, Neurotransmitter / Q000037:antagonists & inhibitors / Q000502:physiology*; D014868:Water Deprivation
D007705:Kinins; D018041:Receptors, Neurokinin-2; D017981:Receptors, Neurotransmitter