[The morphofunctional characteristics of the adrenal cortical substance after exposure to an adrenocorticolytic agent].
The administration of dioxidine to 1-month-old rats (200 mg/kg i.p.) results in destructive alterations of adrenocorticocytes, damage of their mitochondria, dramatic reduction of activity of succinic- and 3 beta-ol-steroid dehydrogenases. The abolition of the drug is followed within 6, 12, 30 days by progress of alternative changes, inhibition of growth of the adrenals which results 30 days later in atrophy of the whole gland and the cortical substance.
Ryzhavskiĭ
B Ia
BIa
Ivashkov
E A
EA
D015096:3-Hydroxysteroid Dehydrogenases / Q000187:drug effects / Q000378:metabolism; D000302:Adrenal Cortex / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D050356:Lipid Metabolism; D009929:Organ Size / Q000187:drug effects; D011810:Quinoxalines / Q000494:pharmacology*; D051381:Rats; D013385:Succinate Dehydrogenase / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors
D000890:Anti-Infective Agents; D011810:Quinoxalines; C001077:dioxidine; D015096:3-Hydroxysteroid Dehydrogenases; D013385:Succinate Dehydrogenase
Morfofunktsional'naia kharakteristika korkovogo veshchestva nadpochechnikov posle vozdeĭstviia adrenokortikoliticheskim agentom.