[A comparison of the self-stimulation reaction and of conditioned place preference with fenamine administration in rats].
The reinforcing properties of different doses of amphetamine (1 and 5 mg/kg) were examined using two variants of self-stimulation reaction (in the Skinner box and locomotor self-stimulation in a shuttle box) and place preference test. Amphetamine in dose of 1 mg/kg increased the frequency of self-stimulation in the Skinner box and prolonged the time of rat staying in active zone of a shuttle box to a greater degree than 5 mg/kg of the drug. On the contrary, the aversive phase of self-stimulation, determined by a coefficient of "disagreement", grew higher after 5 mg/kg amphetamine than following 1 mg/kg. The study of effects by place preference test revealed the other regularity: the most positive reinforcing properties possessed the drug in a dose of 5 mg/kg. Thus, there are dissociation between the two doses of amphetamine (1 and 5 mg/kg) in their action on different physiological conditioned responses. The mechanisms of this dissociation are discussed.
Lebedev
A A
AA
Shabanov
P D
PD
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D007026:Hypothalamic Area, Lateral / Q000187:drug effects / Q000502:physiology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012054:Reinforcement, Psychology; D012653:Self Stimulation / Q000187:drug effects* / Q000502:physiology; D013037:Spatial Behavior
D000661:Amphetamine
Soostavlenie reaktsii samostimuliatsii i uslovnogo predpochteniia mesta pri vvedeniia fenamina u krys.