Liver regeneration following portacaval shunt in rats: 3',5'-cyclic AMP changes in plasma and liver tissue.
Hepatic regeneration following portacaval shunt was evaluated in the light of the changes of 3',5'-cyclic AMP (cAMP) levels in plasma and liver tissue, and also plasma cAMP levels after glucagon administration, using a 70% hepatectomy and portacaval shunt model in rats. Ratios of liver to body weight recovered to 60% of pre-operative ratios 2 weeks after the operation. Plasma cAMP level decreased slightly, but insignificantly, 1 day and 3 days after the operation, then recovered to the pre-operative level. Hepatic cAMP concentration increased for 2 weeks after the operation. Plasma cAMP levels induced after glucagon administration did not increase until 3 days after the operation and were only 50% of pre-operative levels 4 weeks after the operation. From these results, liver regeneration following the portacaval shunt was remarkably delayed, but continued until at least 2 weeks after the operation.
Hata
Y
Y
First Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan.
Yoshikawa
Y
Y
Une
Y
Y
Sasaki
F
F
Nakajima
Y
Y
Takahashi
H
H
Namieno
T
T
Uchino
J
J
D000818:Animals; D000242:Cyclic AMP / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000737:chemistry*; D008115:Liver Regeneration / Q000502:physiology*; D008297:Male; D011167:Portacaval Shunt, Surgical; D051381:Rats; D011919:Rats, Inbred Strains
D000242:Cyclic AMP