title: Kininogenase activity of rSMT3, a rat submandibular gland tonin.
abstract: rSMT3, a tonin like angiotensin II generating enzyme present in rSMG presents a potent oxytocic effect on the isolated rat uterus, which was blocked by a B2 bradykinin receptor antagonist. Under optimal conditions of pH, rSMT3 liberates kinin at rate 19-fold greater than angiotensin II.
authors.affiliation: Department of Physiology and Biophysics, Universidade Federal de Minas Gerais, Belo Horizonte; São Paulo, Brazil.
authors.forename: G W
authors.initials: GW
authors.lastname: Araujo
authors.forename: A M
authors.initials: AM
authors.lastname: Silva
authors.forename: J B
authors.initials: JB
authors.lastname: Pesquero
authors.forename: C J
authors.initials: CJ
authors.lastname: Lindsey
authors.forename: W T
authors.initials: WT
authors.lastname: Beraldo
authors.forename: J L
authors.initials: JL
authors.lastname: Pesquero
mesh_terms: D000804:Angiotensin II / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D001681:Biological Assay; D001794:Blood Pressure / Q000187:drug effects; D001920:Bradykinin / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D005260:Female; D066298:In Vitro Techniques; D007610:Kallikreins / Q000378:metabolism*; D007700:Kinetics; D007704:Kininogens / Q000494:pharmacology; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012504:Saralasin / Q000494:pharmacology; D013363:Submandibular Gland / Q000201:enzymology*; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000187:drug effects / Q000502:physiology
chemical_list: D007704:Kininogens; D000804:Angiotensin II; D007703:Peptidyl-Dipeptidase A; D007610:Kallikreins; D012504:Saralasin; D001920:Bradykinin