The incidence and consequences of cytomegalovirus transmission via blood transfusion to low birth weight, premature infants in north east Scotland.
In a 2-year study involving 133 premature low birth weight (less than 1,500 g) infants, the impact of CMV infection via blood transfusion was assessed. 8.4% (7 out of 83) of transfused infants and 10% (7 out of 70) of those exposed to seropositive blood acquired CMV. In those less than 1,250 g the infection rate rose to 13.2% (7 out of 46). Seropositive infants were at a higher risk of acquiring CMV infection than seronegative ones. CMV infection did not give rise to specific immediate morbidity, and no deaths were attributed to CMV. The only source of nosocomial CMV infection was the transfused seropositive blood. Based on these findings, it was possible to formulate a CMV transfusion policy to premature infants in our region.
Galea
G
G
Aberdeen and North East of Scotland, Blood Transfusion Service, Royal Infimary, Foresterhill, UK.
Urbaniak
S J
SJ
D000914:Antibodies, Viral / Q000032:analysis; D001724:Birth Weight; D001803:Blood Transfusion / Q000592:standards; D003428:Cross Infection / Q000453:epidemiology / Q000517:prevention & control / Q000635:transmission*; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000453:epidemiology / Q000517:prevention & control / Q000635:transmission*; D004198:Disease Susceptibility; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007112:Immunity, Maternally-Acquired; D016867:Immunocompromised Host; D015994:Incidence; D007226:Infant Mortality; D007230:Infant, Low Birth Weight / Q000276:immunology; D007231:Infant, Newborn; D007234:Infant, Premature / Q000276:immunology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology; D012606:Scotland / Q000453:epidemiology; D065227:Transfusion Reaction
D000914:Antibodies, Viral