HHV-6 inhibition by two polar compounds.
Dimethyl sulphoxide and dimethyl formamide, two polar compounds and powerful cell differentiation inducers, inhibit HHV-6 infection when added to HHV-6-infected HSB2 cultures. This was established by a delay in the time-course of infection and in the development of virus-induced cytopathic effects. Furthermore, viral titration of supernatants showed a significant reduction (3 log10) of the number of infectious particles. Electron microscopy confirmed that viable cells and extracellular virions were present in the cultures containing the polar compounds, while in the non-treated cultures all cells were lysed and no extracellular virus was evident. The mode of action of these compounds is still unclear and warrants further investigation.
Viza
D
D
U.R.A. C.N.R.S., Laboratoire d'Immunobiologie, Faculté de Médecine, Paris, France.
Aranda-Anzaldo
A
A
Ablashi
D
D
Kramarsky
B
B
D000998:Antiviral Agents / Q000494:pharmacology*; D002213:Capsid / Q000648:ultrastructure; D002460:Cell Line; D002467:Cell Nucleus / Q000382:microbiology / Q000648:ultrastructure; D002470:Cell Survival / Q000187:drug effects; D003588:Cytopathogenic Effect, Viral; D003593:Cytoplasm / Q000382:microbiology / Q000648:ultrastructure; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D004126:Dimethylformamide / Q000494:pharmacology*; D015654:Herpesvirus 6, Human / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure; D006801:Humans; D008854:Microscopy, Electron; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D004126:Dimethylformamide; D004121:Dimethyl Sulfoxide