[Acute undifferentiated leukemia from the viewpoints of diagnosis and therapy].
Myeloperoxidase (MPO)- and Sudan Black B-not more than 3%-positive, esterase staining-negative, lymphoid, megakaryocyte lineage and erythroid surface marker-negative and electron microscopic platelet peroxidase-negative acute leukemia (AL) was diagnosed as acute undifferentiated leukemia (AUL), and myeloid marker (CD13, CD33), electron microscopic MPO (EMMPO), and DNA analysis of immunoglobulin heavy chain and T cell receptor as well as chemotherapy and its reactivity were examined. Of 239 cases of AL, 10 (4.2%) were AUL, and of these 10 cases, 9 were CD13 or CD33-positive AML-MO (MO) cases. Of 9 cases examined for EMMPO, 4 (44%) were positive, and of 3 cases of MO subjected to DNA analysis, 1 and 1 showed rearrangements of immunoglobulin heavy chain and T cell receptor beta chain, respectively. Of 6 cases of MO on myeloid induction therapy, 1 and 1 showed complete remission (CR) and partial remission (PR), respectively, each having lymphoid genotype, and 4 showed no remission (NR), being 3 of them EMMPO-positive. Of 2 cases on lymphoid induction therapy, 1 and 1 showed CR and NR, respectively, the former being EMMPO-positive MO. BHAC-EM therapy with behenoyl cytosine arabinoside, VP-16 and mitoxantrone performed on 2 cases refractory to any one of both these myeloid and lymphoid induction therapies led to CR in all these 2 cases.
Tsunoda
S
S
Division of Hematology, Omiya Medical Center, Jichi Medical School.
Yoshida
M
M
Takagi
S
S
Sasaki
R
R
Muroi
K
K
Hoshino
M
M
Izumi
T
T
Imagawa
S
S
Ema
H
H
Suzuki
T
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007938:Leukemia / Q000175:diagnosis* / Q000188:drug therapy*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009195:Peroxidase / Q000032:analysis
D009195:Peroxidase