title: Isolation of novel lignans, heteroclitins F and G, from the stems of Kadsura heteroclita, and anti-lipid peroxidative actions of heteroclitins A-G and related compounds in the in vitro rat liver homogenate system.
abstract: From the stems of Kadsura heteroclita, two new lignans named heteroclitins F and G were isolated and their structures were determined by various spectroscopic means including an X-ray diffraction method. Dibenzocyclooctadiene type lignans and related compounds isolated from the stems of K. heteroclita, potently inhibited the lipid peroxidation in the rat liver homogenate stimulated by Fe(2+)-ascorbic acid, CCl4-reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) and adenosine 5'-diphosphate-NADPH.
authors.affiliation: Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
authors.forename: X W
authors.initials: XW
authors.lastname: Yang
authors.forename: H
authors.initials: H
authors.lastname: Miyashiro
authors.forename: M
authors.initials: M
authors.lastname: Hattori
authors.forename: T
authors.initials: T
authors.lastname: Namba
authors.forename: Y
authors.initials: Y
authors.lastname: Tezuka
authors.forename: T
authors.initials: T
authors.lastname: Kikuchi
authors.forename: D F
authors.initials: DF
authors.lastname: Chen
authors.forename: G J
authors.initials: GJ
authors.lastname: Xu
authors.forename: T
authors.initials: T
authors.lastname: Hori
authors.forename: M
authors.initials: M
authors.lastname: Extine
mesh_terms: D000818:Animals; D066298:In Vitro Techniques; D017705:Lignans; D008031:Lignin / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats
chemical_list: D017705:Lignans; D010936:Plant Extracts; D008031:Lignin