Borage or primrose oil added to standardized diets are equivalent sources for gamma-linolenic acid in rats.
The aim of this study was to evaluate the effect of different doses and sources of dietary gamma-linolenic acid (GLA) on the tissue phospholipid fatty acid composition. Rats fed four different levels of GLA (2.3, 4.6, 6.4 and 16.2 g of GLA/kg diet) in the form of either borage oil or evening primrose oil during 6 wk were compared with animals fed corn oil. The levels of dihomo-gamma-linolenic acid (DHLA) and GLA showed a significant dose-related increase in liver, erythrocyte and aorta phospholipids. Moreover, the arachidonic acid/DHLA ratios in tissues decreased with increasing intake of dietary GLA. There was no significant difference in tissue GLA and DHLA levels within groups given equal amounts of dietary GLA either as borage oil or evening primrose oil. The amount of dietary GLA administered did not significantly influence prostaglandin E2 production in stimulated aortic rings and thromboxane B2 levels in serum; however, an increase in prostaglandin E1 derived from DHLA was observed in the supernatants of stimulated aorta.
Raederstorff
D
D
F. Hoffmann-La Roche Ltd., Department of Vitamin and Nutrition Research, Basel, Switzerland.
Moser
U
U
D015126:8,11,14-Eicosatrienoic Acid / Q000097:blood; D000704:Analysis of Variance; D000818:Animals; D001011:Aorta / Q000737:chemistry; D001682:Biological Availability; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D015232:Dinoprostone / Q000032:analysis; D004912:Erythrocytes / Q000737:chemistry; D005227:Fatty Acids / Q000032:analysis; D005228:Fatty Acids, Essential / Q000494:pharmacology*; D005526:Food, Formulated / Q000592:standards; D008041:Linoleic Acids; D008042:Linolenic Acids / Q000097:blood / Q000494:pharmacology*; D008099:Liver / Q000737:chemistry; D008297:Male; D031665:Oenothera biennis; D010743:Phospholipids / Q000737:chemistry; D010938:Plant Oils / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013929:Thromboxane B2 / Q000097:blood; D017965:gamma-Linolenic Acid
D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D005228:Fatty Acids, Essential; D008041:Linoleic Acids; D008042:Linolenic Acids; D010743:Phospholipids; D010938:Plant Oils; C028498:evening primrose oil; D013929:Thromboxane B2; D017965:gamma-Linolenic Acid; C079363:borage oil; D015126:8,11,14-Eicosatrienoic Acid; D015232:Dinoprostone