title: [Epidemiology of cleft palate and cleft lip inthe Rhône-Alpes/Auvergne/Jura region. Apropos of 903 cases registered 1978-1987].
abstract: Data from the Rhône-Alpes/Auvergne birth defects registry have been used to realise an epidemiological analysis of facial clefts (cleft palate and total cleft lip). Between 1978 and 1987, 903 cases have been ascertained giving an incidence of 0.67 per 1,000 for cleft lips with/without cleft palate (CLP) and 0.44 per 1,000 for cleft palates (CP). Several epidemiological characteristics have been studied: CLP are more frequent in males, and CP are more frequent in females. There is no detectable time trend, and birthweights are significantly lower in affected children than in the general population. There are more twins, more maternal epilepsy and more stimulations of ovulation in the studied sample than in the general population. The ranks of birth are higher in CP and CLP than in general population. The incidence of facial clefts in first degree relatives is 50 to 60 times the one in the general population, which is comparable to the literature findings.
authors.affiliation: Institut européen des génomutations, Lyon, France.
authors.forename: S
authors.initials: S
authors.lastname: Long
authors.forename: E
authors.initials: E
authors.lastname: Robert
authors.forename: B
authors.initials: B
authors.lastname: Laumon
authors.forename: E
authors.initials: E
authors.lastname: Pradat
authors.forename: J M
authors.initials: JM
authors.lastname: Robert
mesh_terms: D002971:Cleft Lip / Q000453:epidemiology*; D002972:Cleft Palate / Q000453:epidemiology*; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010290:Parents; D012042:Registries / Q000706:statistics & numerical data; D012189:Retrospective Studies; D012744:Sex Ratio
vernacular_title: Epidémiologie des fentes labiales et palatines dans la région Rhône-Alpes/Auvergne/Jura. A propos de 903 cas enregistrés entre 1978 et 1987.