Epstein-Barr virus-transformed B lymphocytes produce low molecular mass molecules with autocrine growth factor and competence factor activity.
A human Epstein-Barr virus (EBV)-positive lymphoblastoid B cell line, named BA-D10-4, produces a factor of a molecular mass less than 10 kDa that promotes cell proliferation of both BA-D10-4 cells and other human T or B lymphoid cell lines, either EBV-positive or -negative. The factor synergizes with higher molecular mass autocrine growth factors and makes both BA-D10-4 cells and B cell lines from Burkitt's lymphoma, but not cells from T cell leukemia, more responsive to interleukin-1 and interleukin-6. Therefore, this low molecular mass factor seems to be an autocrine growth factor per se and to have the characteristics of a competence factor.
Garzelli
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C
Department of Biomedicine, University of Pisa, Italy.
Bazzichi
A
A
Dayah
A M
AM
Manunta
M
M
Incaprera
M
M
Falcone
G
G
D001402:B-Lymphocytes / Q000378:metabolism*; D002461:Cell Line, Transformed; D002850:Chromatography, Gel; D004247:DNA / Q000096:biosynthesis; D006133:Growth Substances / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology; D004854:Herpesvirus 4, Human; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology; D015850:Interleukin-6 / Q000494:pharmacology; D008970:Molecular Weight
D006133:Growth Substances; D007375:Interleukin-1; D015850:Interleukin-6; D004247:DNA