13-hydroxyoctadecadienoic acid attenuates oedema formation induced by leukotriene B4 in vivo in rabbit skin.
Intradermal 13-hydroxyoctadecadienoic acid (13-HODE; 10(-11)-10(-9) mol/site) inhibited oedema formation induced by the neutrophil-dependent mediator leukotriene B4 (LTB4) in the presence of calcitonin gene-related peptide (CGRP; 10(-11) mol/site) in rabbit skin. In contrast, the responses to the direct acting mediators bradykinin and histamine were unaffected by 13-HODE. 13-HODE failed to induce oedema formation in rabbit skin when injected alone or in the presence of the potent vasodilator CGRP. These results present a novel interaction between 13-HODE and LTB4 that could have important implications in the pathogenesis of inflammation.
Buckley
T L
TL
Department of Pharmacology, Faculty of Pharmacy, University of Utrecht, Netherlands.
Van de Velde
M J
MJ
Henricks
P A
PA
Engels
F
F
Nijkamp
F P
FP
D000704:Analysis of Variance; D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000502:physiology; D004487:Edema / Q000503:physiopathology / Q000517:prevention & control*; D007975:Leukotriene B4 / Q000037:antagonists & inhibitors* / Q000502:physiology; D008041:Linoleic Acids / Q000494:pharmacology*; D011817:Rabbits; D012867:Skin / Q000187:drug effects* / Q000503:physiopathology
D008041:Linoleic Acids; D007975:Leukotriene B4; C024348:13-hydroxy-9,11-octadecadienoic acid; D015740:Calcitonin Gene-Related Peptide