Stool examination and rectal biopsy in the diagnosis and evaluation of therapy of schistosomiasis mansoni.
From each of a group of 217 adult males selected through enzyme-immunoassay or skin-test (Group A), six stool samples were examined by both the Lutz/Hoffman, Pons & Janer (Lutz/HPJ) and Kato/Katz methods. In addition, one oogram of the rectal mucosa was performed. By these methods, schistosomiasis was detected in 44.7%, 47.5% and 40.1% of the individuals respectively. To evaluate the methods in the assessment of cure, the last 40 patients from group A, treated with a single oral dose of oxamniquine at 15 mg/kg were followed up for six months (Group B). The criteria for parasitological cure included three stool examinations by Kato/Katz and Lutz/HPJ methods, one, three and six months post-treatment and a rectal biopsy between the fourth and sixth months post-treatment. The examinations were negative in 87.5%, 90% and 95% of the patients, respectively. The efficacy of oxamniquine was 82.5% when the three methods were considered together and there was no statistically significant difference between the sensitivity of the individual methods.
Rabello
A L
AL
Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Brasil.
Rocha
R S
RS
de Oliveira
J P
JP
Katz
N
N
Lambertucci
J R
JR
D000293:Adolescent; D000328:Adult; D000818:Animals; D001706:Biopsy; D001938:Brazil; D005069:Evaluation Studies as Topic; D005243:Feces / Q000469:parasitology*; D006801:Humans; D008297:Male; D008722:Methods; D008889:Military Personnel; D010073:Oxamniquine / Q000008:administration & dosage; D012007:Rectum / Q000469:parasitology / Q000473:pathology*; D012550:Schistosoma mansoni / Q000302:isolation & purification*; D012555:Schistosomiasis mansoni / Q000175:diagnosis* / Q000188:drug therapy / Q000469:parasitology / Q000473:pathology; D013997:Time Factors
D010073:Oxamniquine