The low-chloride cough response is not inhibited by a single, high dose of aspirin.
The effect of a single, high dose of aspirin has been assessed against low chloride cough challenge. The drug does not affect the cough response, suggesting that airway prostaglandin generation is not responsible for the tussive activity of low chloride solution.
Stone
R A
RA
Department of Thoracic Medicine, National Heart and Lung Institute, London.
Barnes
P J
PJ
Fuller
R W
RW
D001241:Aspirin / Q000494:pharmacology*; D001639:Bicarbonates; D002712:Chlorides / Q000008:administration & dosage; D003371:Cough / Q000139:chemically induced / Q000503:physiopathology*; D004311:Double-Blind Method; D006801:Humans; D012964:Sodium; D017693:Sodium Bicarbonate
D001639:Bicarbonates; D002712:Chlorides; D017693:Sodium Bicarbonate; D012964:Sodium; D001241:Aspirin