title: The repair of tracheal defects using bioabsorbable mesh.
abstract: This study compares the use of synthetic bioabsorbable mesh with that of non-absorbable mesh in repairing tracheal defects. Two patch windows, each 1 cm x 1 cm, were created on the ventral wall of the cervical trachea in 12 adult mongrel dogs. One window was repaired using a bioabsorbable polyglycolic acid (PGA) mesh graft, and the other using a nonabsorbable Marlex mesh (polypropylene mesh; PP mesh) (C. R. Bard, Inc., Billerica, MA) graft. The dogs were killed at intervals from 1 to 35 weeks after surgery. Macroscopically, there was no difference between the two mesh groups until 3 weeks after surgery. At 6 weeks in the PP mesh group, the connective tissue over the mesh was remarkably thick, and after 9 weeks, constriction by scarlike tissue was evident, as compared with the PGA mesh group, which showed no constriction. Microscopically, epithelium covered the whole mesh in both groups at 6 weeks. However, in the PP mesh group, flat and poorly differentiated cells occupied a large area, and after 9 weeks the height of the epithelial cells in the PP mesh group was less than in the PGA mesh group. Furthermore, in the PP mesh group, nonciliated cells occupied a large area even at 15 weeks, and the submucous connective tissue layer was thicker than in the PGA mesh group after 6 weeks. The results indicate that, from the point of view of wound-healing, bioabsorbable mesh may be more adequate for repairing tracheal defects.
authors.affiliation: Department of Artificial Organs, Kyoto University, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Okumura
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Takimoto
authors.forename: T
authors.initials: T
authors.lastname: Kiyotani
authors.forename: Y H
authors.initials: YH
authors.lastname: Lee
authors.forename: Y
authors.initials: Y
authors.lastname: Shimizu
authors.forename: K
authors.initials: K
authors.lastname: Tomihata
authors.forename: Y
authors.initials: Y
authors.lastname: Ikada
authors.forename: K
authors.initials: K
authors.lastname: Shiraki
mesh_terms: D000042:Absorption; D000818:Animals; D001672:Biocompatible Materials; D004285:Dogs; D005069:Evaluation Studies as Topic; D008422:Materials Testing; D011100:Polyglycolic Acid; D011126:Polypropylenes; D013526:Surgical Mesh; D013997:Time Factors; D014132:Trachea / Q000473:pathology / Q000601:surgery*
chemical_list: D001672:Biocompatible Materials; D011126:Polypropylenes; D011100:Polyglycolic Acid