A new, semi-automated system for the micro-scale synthesis of [195mPt]cisplatin suitable for clinical studies.
A new, semi-automated system for the microscale synthesis of [195mPt]cisplatin has been developed. Radiochemical yields of up to 70% of pure [195mPt]cisplatin can be obtained routinely e.g. 555-629 MBq (15-17 mCi) from 925 MBq (25 mCi) of [195mPt]Pt metal. Chemical losses during synthesis, and radiation exposure of personnel, have been minimized. These increased yields are the consequence of the elimination of most transfers, and enhanced yields at most steps: ammination losses decreased from 27 to 7%, and at the diiodo- to di-acquo- conversion, from 34 to 11%. The versatility of such a system is discussed.
Anand
D
D
Radiopharmacy Program, University of Southern California, Los Angeles 90033.
Wolf
W
W
D002945:Cisplatin / Q000138:chemical synthesis*; D008722:Methods
D002945:Cisplatin