title: Pituitary adenoma proliferative indices and risk of recurrence.
abstract: Twenty unselected pituitary adenomas have been examined for proliferative indices (PIs), and anterior pituitary hormone expression. All but two of the tumours were non-functional with proliferative indices from less than 0.1 to 0.5%. Two tumours were null cell adenomas with PIs less than 0.1 and 0.2%. The PIs of the three recurrent tumours was less than 1.0%. Gonadotrophin and TSH immunoreactivity was heterogenous and was found in 12/20 (60%) of the tumours. There was no significant relationship between PI, hormone expression or any other measured parameter. The biological behaviour of pituitary adenomas with a PI of less than 0.1% is uncertain, but those with a PI of greater than 0.1% are more likely to recur although longer follow-up is needed to confirm this.
authors.affiliation: Department of Neurosurgery, Midland Centre for Neurosurgery and Neurology.
authors.forename: P
authors.initials: P
authors.lastname: Carboni
authors.forename: A
authors.initials: A
authors.lastname: Detta
authors.forename: E R
authors.initials: ER
authors.lastname: Hitchcock
authors.forename: R
authors.initials: R
authors.lastname: Postans
mesh_terms: D000236:Adenoma / Q000097:blood / Q000378:metabolism / Q000473:pathology*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000368:Aged; D001973:Bromodeoxyuridine; D002455:Cell Division; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D010911:Pituitary Neoplasms / Q000097:blood / Q000378:metabolism / Q000473:pathology*; D011388:Prolactin / Q000097:blood; D012307:Risk Factors
chemical_list: D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D001973:Bromodeoxyuridine