Survey on spontaneous peripheral neuropathy in aging rats.
The incidence of peripheral neuropathy in rats (Charles River bred, caesarean derived, Sprague-Dawley origin) obtained from long term studies over a 10 year period is reported. The survey included peripheral nerve samples from 14,237 males and 13,668 females. The incidence of peripheral neuropathy is 23% in untreated males and 18% in untreated females at 80-104 weeks of age. The total incidence in all rats in the survey was somewhat higher in males than females. The light and electron microscopic features of age-related peripheral neuropathy in rats is described. The peripheral neuropathy was spontaneous in origin and was age-related.
Majeed
S K
SK
Huntingdon Research Center Ltd., England.
D000375:Aging / Q000473:pathology*; D000818:Animals; D005260:Female; D006651:Histocytochemistry; D008297:Male; D008928:Mitochondria / Q000648:ultrastructure; D009410:Nerve Degeneration; D009474:Neurons / Q000648:ultrastructure; D010523:Peripheral Nervous System Diseases / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley