Isolation of novel lignans, heteroclitins F and G, from the stems of Kadsura heteroclita, and anti-lipid peroxidative actions of heteroclitins A-G and related compounds in the in vitro rat liver homogenate system.
From the stems of Kadsura heteroclita, two new lignans named heteroclitins F and G were isolated and their structures were determined by various spectroscopic means including an X-ray diffraction method. Dibenzocyclooctadiene type lignans and related compounds isolated from the stems of K. heteroclita, potently inhibited the lipid peroxidation in the rat liver homogenate stimulated by Fe(2+)-ascorbic acid, CCl4-reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) and adenosine 5'-diphosphate-NADPH.
Yang
X W
XW
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
Miyashiro
H
H
Hattori
M
M
Namba
T
T
Tezuka
Y
Y
Kikuchi
T
T
Chen
D F
DF
Xu
G J
GJ
Hori
T
T
Extine
M
M
D000818:Animals; D066298:In Vitro Techniques; D017705:Lignans; D008031:Lignin / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats
D017705:Lignans; D010936:Plant Extracts; D008031:Lignin