title: [H(+)-ATPase and H(+), K(+)-ATPase].
abstract: Two different types of proton transporting ATPases, v-and p-type H(+)-ATPases engage in epithelial ion transport. Properties, function, molecular structure and distribution of these H(+)-ATPase (v-type) and H+, K(+)-ATPase (p-type) are summarized here. Intraorganellar spaces, such as lysosome, synapse, multivesicular body, are acidified by the vacuole-type H(+)-ATPases. Secretion of proton by some types of intercalated cells of kidney collecting tubules is due to H(+)-ATPase. Gastric proton secretion is due to H+, K(+)-ATPase. Proton secretion and absorption of potassium by distal colon is due to p-type ATPase.
authors.affiliation: Department of Pharmaceutical Physiology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University.
authors.forename: N
authors.initials: N
authors.lastname: Takeguchi
mesh_terms: D000818:Animals; D017506:H(+)-K(+)-Exchanging ATPase / Q000502:physiology*; D006801:Humans; D006180:Proton-Translocating ATPases / Q000502:physiology*
chemical_list: D017506:H(+)-K(+)-Exchanging ATPase; D006180:Proton-Translocating ATPases