title: The electrically evoked, tachykinin-mediated contractile response of the isolated rabbit iris sphincter muscle involves NK1 receptors only.
abstract: In the presence of atropine and guanethidine, the electrically evoked contractile response of the rabbit iris sphincter muscle is mediated by tachykinins. Two highly selective NK1 receptor antagonists, (+/-) CP-96,345 and spantide II, concentration dependently inhibited the contraction with pIC50 values of 5.4 and 6.1, respectively. A highly selective NK2 receptor antagonist, actinomycin D, was inactive, while another NK2 receptor antagonist of moderate selectivity, MEN 10,376, produced a slight inhibition of the contraction at high concentrations. Our results suggest that the electrically evoked, tachykinin-mediated contractile response of the rabbit iris sphincter muscle involves NK1 receptors only.
authors.affiliation: Department of Pharmacology, Lund University, Sweden.
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Wang
authors.forename: R
authors.initials: R
authors.lastname: Håkanson
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D005260:Female; D007498:Iris / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D015288:Neurokinin A / Q000378:metabolism*; D011817:Rabbits; D018041:Receptors, Neurokinin-2; D017981:Receptors, Neurotransmitter / Q000187:drug effects* / Q000502:physiology; D015320:Tachykinins / Q000494:pharmacology*
chemical_list: D018041:Receptors, Neurokinin-2; D017981:Receptors, Neurotransmitter; D015320:Tachykinins; D015288:Neurokinin A