Neurotensin stimulates the growth and secretion of rat adrenal zona glomerulosa.
Within 2 days neurotensin (NT) and ACTH administrations markedly enhanced the average volume of zona glomerulosa (ZG) cells and plasma aldosterone concentration (PAC) in intact rats. In dexamethasone-treated rats, both NT and ACTH evoked a clearcut ZG-cell hypertrophy, but only NT was able to raise PAC. In conclusion, our findings indicate that NT is a potent stimulator of the growth and secretion of rat ZG in vivo, and suggest that the mechanism underlying this action of NT does not involve the well-known NT-induced stimulation of ACTH release.
Malendowicz
L K
LK
Department of Histology and Embryology, University School of Medical Sciences, Poznan, Poland.
Nussdorfer
G G
GG
Majchrzak
M
M
Nowak
M
M
Lesniewska
B
B
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000450:Aldosterone / Q000378:metabolism*; D000818:Animals; D048429:Cell Size / Q000187:drug effects; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D006984:Hypertrophy; D009496:Neurotensin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012636:Secretory Rate / Q000187:drug effects; D013268:Stimulation, Chemical; D015384:Zona Glomerulosa / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism
D009496:Neurotensin; D000450:Aldosterone; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone