Active oxygen species, articular inflammation and cartilage damage.
Rheumatoid arthritis and osteoarthritis are age-related diseases, in which degenerative changes (arthrosis) and superimposed inflammatory reactions (arthritis) lead to progressive destruction of the joints. Active oxygen species derived from various sources play a role in this process, which may be influenced by appropriate treatment with antioxidants and free radical scavengers.
Henrotin
Y
Y
Laboratory of Radioimmunoassay, University Sart-Tilman, Liége, Belgium.
Deby-Dupont
G
G
Deby
C
C
Franchimont
P
P
Emerit
I
I
D000375:Aging / Q000502:physiology*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001168:Arthritis / Q000188:drug therapy / Q000503:physiopathology*; D002358:Cartilage, Articular / Q000254:growth & development / Q000503:physiopathology; D004249:DNA Damage; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D006878:Hydroxides / Q000378:metabolism; D017665:Hydroxyl Radical; D007249:Inflammation; D007596:Joints / Q000254:growth & development / Q000503:physiopathology; D015227:Lipid Peroxidation; D014969:Xanthine Oxidase / Q000378:metabolism
D000975:Antioxidants; D005609:Free Radicals; D006878:Hydroxides; D017665:Hydroxyl Radical; D014969:Xanthine Oxidase