Intraperitoneally injected cholecystokinin-octapeptide activates pica in rats.
Cholecystokinin-octapeptide (CCK-8) was injected intraperitoneally into rats to see if it could cause them to eat kaolin (clay)--a pica behavior which has been shown to indicate gastric distress. In the first study, a single large dose of CCK-8 (20 micrograms/kg) failed to produce pica. In the second study, 4 smaller doses of CCK-8 (8 micrograms/kg), 30 min apart, produced significant ingestion of kaolin compared to the baseline condition of vehicle injections. The pica was comparable to that observed in another group of rats given a toxic dose of LiCl (127 mg/kg, IP). It is concluded that intraperitoneal injections of CCK-8 can induce a state of gastric distress in the rat.
McCutcheon
B
B
Department of Psychology, State University of New York, Albany 12222.
Ballard
M
M
McCaffrey
R J
RJ
D000818:Animals; D002712:Chlorides / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D007616:Kaolin; D008094:Lithium / Q000494:pharmacology; D018021:Lithium Chloride; D008297:Male; D010842:Pica / Q000139:chemically induced*; D051381:Rats; D011919:Rats, Inbred Strains; D012844:Sincalide / Q000494:pharmacology*; D013649:Taste / Q000187:drug effects
D002712:Chlorides; D007616:Kaolin; D008094:Lithium; D018021:Lithium Chloride; D012844:Sincalide