Hepatic rhabdomyomatous tumor: late sequel of a fetal rhabdomyomatous nephroblastoma.
A mesenchymal tumor with the macroscopic and microscopic features of a fetal rhabdomyoma arose in the liver of a 14-year-old boy. Thirteen years previously this boy had been treated for a fetal rhabdomyomatous nephroblastoma with nephrectomy and--for subsequent peritoneal disseminations--with surgical excision, radiotherapy, and chemotherapy. The unusual hepatic location of the rhabdomyomatous tumor in this patient supports the view that this mature tumor developed from a metastasis of the original nephroblastoma. As such, this case may represent an example of irreversible change of a malignant process into a benign tumor probably caused by the action of systemic chemotherapy.
van der Kwast
T H
TH
Department of Pathology, Erasmus University, Rotterdam, The Netherlands.
ten Kate
F J
FJ
Vuzevski
V D
VD
Madern
G C
GC
Terpstra
O T
OT
D000293:Adolescent; D006801:Humans; D007680:Kidney Neoplasms / Q000378:metabolism / Q000473:pathology*; D008113:Liver Neoplasms / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009124:Muscle Proteins / Q000378:metabolism; D016609:Neoplasms, Second Primary / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D012207:Rhabdomyoma / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D013997:Time Factors; D009396:Wilms Tumor / Q000378:metabolism / Q000473:pathology*
D009124:Muscle Proteins