Effect of oat bran on plasma cholesterol and bile acid excretion in nine subjects with ileostomies.
A higher excretion of dry matter, fat, nitrogen, energy, and total bile acids in ileal effluents; a lower plasma low-density-lipoprotein (LDL) and total cholesterols (12.1% and 9.0% lower respectively); but no change in plasma high-density-lipoprotein (HDL) cholesterol or apolipoproteins A-I and B were observed in nine subjects with ileostomies when they consumed an oat-bran, bread-based, high-fiber diet (HFD) as compared with a wheat-flour, bread-based, low-fiber diet (LFD) for 3 wk with a crossover design. Of the nine subjects only the subjects with a low daily excretion of bile acids had an elevated excretion of total bile acids during the HFD compared with the LFD. Total cholesterol, LDL cholesterol, and apolipoprotein B in plasma also decreased by 11.3%, 15.3%, and 10.7%, respectively, after consumption of the HFD for 3 wk.
Zhang
J X
JX
Department of Pathology, University of Umeå, Sweden.
Hallmans
G
G
Andersson
H
H
Bosaeus
I
I
Aman
P
P
Tidehag
P
P
Stenling
R
R
Lundin
E
E
Dahlgren
S
S
D000328:Adult; D000368:Aged; D000924:Anticholesteremic Agents / Q000008:administration & dosage*; D001647:Bile Acids and Salts / Q000378:metabolism*; D001939:Bread; D002635:Chenodeoxycholic Acid / Q000378:metabolism; D002784:Cholesterol / Q000097:blood*; D019826:Cholic Acid; D002793:Cholic Acids / Q000378:metabolism; D004043:Dietary Fiber / Q000008:administration & dosage*; D002523:Edible Grain; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D007081:Ileostomy; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009584:Nitrogen / Q000378:metabolism; D011897:Random Allocation
D000924:Anticholesteremic Agents; D001647:Bile Acids and Salts; D002793:Cholic Acids; D004043:Dietary Fiber; D008055:Lipids; D002635:Chenodeoxycholic Acid; D002784:Cholesterol; D019826:Cholic Acid; D009584:Nitrogen