Cytogenetic analysis of an adenoid cystic carcinoma of the Bartholin's gland. A rare, semimalignant tumor of the female genitourinary tract.
Cytogenetic analysis has been performed on short-term cultures from a 56-year-old woman suffering from an adenoid cystic carcinoma of Bartholin's gland. Beside a normal female karyotype, the tumor revealed an abnormal cell line with complex chromosome changes involving the chromosomes 1, 4, 6, 11, 22, and 14. The mainly structural and nonbalanced rearrangements led to the loss of the chromosome segments 1p31----qter, 4q22----q28, 6p12----qter, 11p11.2----pter, 14q24----qter, and 22q13----qter. Clonal numerical aberrations were not observed. To our knowledge, such a tumor has to-date not been cytogenetically investigated.
Kiechle-Schwarz
M
M
Department of Gynecology and Obstetrics, Albert-Ludwigs University, Freiburg, Germany.
Kommoss
F
F
Schmidt
J
J
Lukovic
L
L
Walz
L
L
Bauknecht
T
T
Pfleiderer
A
A
D001472:Bartholin's Glands / Q000473:pathology / Q000601:surgery; D003528:Carcinoma, Adenoid Cystic / Q000235:genetics*; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1; D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D002892:Chromosomes, Human, Pair 22; D002894:Chromosomes, Human, Pair 4; D002896:Chromosomes, Human, Pair 6; D005260:Female; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D014846:Vulvar Neoplasms / Q000235:genetics* / Q000601:surgery