Presence of transplantable T-lymphoid cells in C57BL/6 mice infected with murine AIDS virus.
The Duplan strain of murine leukemia virus induces murine AIDS in C57BL/6 mice. When spleen cells from C57BL/6 mice infected with the virus were transplanted into nude mice, subcutaneous solid tumors at the transplanted sites were formed and splenomegaly and lymphadenopathy were induced. These transplantable cells were Thy-1- CD4+ alpha-beta T-cell receptor-positive T cells and integrated with the pathogenic defective viral genome. These results indicate that neoplastic cells of T-cell lineage were induced by infecting C57BL/6 mice with murine AIDS virus.
Kubo
Y
Y
Department of Viral Oncology, Faculty of Medicine, Kyoto University, Japan.
Nakagawa
Y
Y
Kakimi
K
K
Matsui
H
H
Iwashiro
M
M
Kuribayashi
K
K
Masuda
T
T
Hiai
H
H
Hirama
T
T
Yanagawa
S
S
D000818:Animals; D014408:Biomarkers, Tumor; D002471:Cell Transformation, Neoplastic; D009052:Leukemia Virus, Murine / Q000502:physiology*; D008221:Lymphoid Tissue / Q000382:microbiology / Q000473:pathology / Q000637:transplantation; D051379:Mice; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D016183:Murine Acquired Immunodeficiency Syndrome / Q000382:microbiology* / Q000473:pathology; D009374:Neoplasms, Experimental; D013154:Spleen / Q000382:microbiology / Q000473:pathology / Q000637:transplantation; D013163:Splenomegaly / Q000209:etiology; D013601:T-Lymphocytes / Q000382:microbiology* / Q000637:transplantation; D016662:Virus Integration
D014408:Biomarkers, Tumor