title: The EGF-inducible protein EIP-1 of migrating normal and malignant rat liver epithelial cells is identical to plasminogen activator inhibitor 1 and is a component of the ECM migration tracks.
abstract: Induction of rat liver epithelial cell migration by epidermal growth factor (EGF) changes the expression pattern of secreted proteins. The expression of the early induced glycoprotein EGF-inducible protein No. 1 (EIP-1) correlates with the migratory behavior of both normal and Ha-ras-transformed, tumorigenic cells and is deposited into the ECM migration tracks. The sequence of two clones from a cDNA library of EGF-induced cells and the amino terminal sequence of the purified protein revealed that EIP-1 is identical to rat plasminogen activator inhibitor 1 (PAI-1). Based on the migration-linked expression pattern of EIP-1/PAI-1 it is proposed that the inhibitor is required for the migration of these cells, but not sufficient to stimulate it.
authors.affiliation: Arbeitsgruppe Zellbiologie, Fakultät für Biologie, Universität Konstanz, Federal Republic of Germany.
authors.forename: T
authors.initials: T
authors.lastname: Seebacher
authors.forename: M
authors.initials: M
authors.lastname: Manske
authors.forename: J
authors.initials: J
authors.lastname: Zoller
authors.forename: J
authors.initials: J
authors.lastname: Crabb
authors.forename: E G
authors.initials: EG
authors.lastname: Bade
mesh_terms: D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002461:Cell Line, Transformed; D002465:Cell Movement; D002478:Cells, Cultured; D003907:Dexamethasone / Q000494:pharmacology; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D005109:Extracellular Matrix / Q000737:chemistry*; D008099:Liver / Q000166:cytology* / Q000378:metabolism; D008114:Liver Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology*; D017395:Plasminogen Activator Inhibitor 1 / Q000032:analysis / Q000096:biosynthesis / Q000737:chemistry*; D014176:Protein Biosynthesis; D011506:Proteins / Q000032:analysis / Q000737:chemistry*; D051381:Rats
chemical_list: D017395:Plasminogen Activator Inhibitor 1; D011506:Proteins; D004815:Epidermal Growth Factor; D003994:Bucladesine; D003907:Dexamethasone