Effect of cis-diaminedichloroplatinum (II) (cis-DDP) on the intracellular Na+/K(+)-ratio in K 562 leukemia cells as revealed by X-ray microanalysis.
Changes of intracellular ionic homeostasis are believed to play a role in the cytostatic action of cis-DDP. It has been observed by means of X-ray microanalysis that cis-DDP did not alter the intracellular Na+/K(+)-ratio of K 562 leukemia cells during incubation periods which lasted shorter than the average doubling time of the cells of nearly 15 h. After 24 h the treated cells displayed at least two main populations in the distribution histogram of the Na+/K(+)-ratio. The results indicated that the passage of cis-DDP through the plasma membrane by itself did not change the monovalent electrolyte balance at the early stage of its action in K 562 cells.
Peschke
T
T
Central Institute of Microbiology and Experimental Therapy, Jena, Germany.
Szállási
Z
Z
Szállási
A
A
Zs-Nagy
I
I
D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology*; D004577:Electron Probe Microanalysis; D006801:Humans; D007938:Leukemia; D011188:Potassium / Q000032:analysis*; D012964:Sodium / Q000032:analysis*; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects*; D014407:Tumor Cells, Cultured
D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D002945:Cisplatin; D011188:Potassium