[Coronary disease of transplanted heart. Physiopathology, prevention].
Coronary artery disease in cardiac transplant recipients is the main cause of mortality after the first postoperative year. This atheroma has unique anatomical features with widespread infiltration of the intima by inflammatory cells. The different physiopathological hypotheses are analysed. Immunological processes are probably responsible, suggesting chronic rejection. The cytomegalovirus could be an inductive mechanism. The classical vascular risk factors probably play a role but their action is not as clear as that of immunological and viral factors. Hyperlipidaemia is a causative mechanism and the predisposing role of steroid therapy is also recognised. From the practical point of view, correction of the classical risk factors is the only available therapeutic possibility at present.
Heim
M
M
Service de médecine interne et endocrinologie, CHU Timone, Marseille.
Nicolino-Peltier
C
C
Metras
D
D
Habib
G
G
Kretmann
B
B
Luccioni
R
R
Bertault-Perez
P
P
D000818:Animals; D003327:Coronary Disease / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D003586:Cytomegalovirus Infections / Q000150:complications; D006084:Graft Rejection; D016027:Heart Transplantation / Q000009:adverse effects* / Q000401:mortality; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D008297:Male; D011817:Rabbits; D012307:Risk Factors
Coronaropathie du coeur greffé. Physiopathologie, prévention.