title: [Neonatal herpes: recurrence after treatment with acyclovir].
abstract: A case of cutaneous herpes relapse with meningitis is reported in a 1.5 month-old infant treated during the first three weeks of life with acyclovir (ACV) for a neonatal herpes infection. Such a relapse has previously been described in older children as well as in adults. In this case report, there was immunological response to herpes virus infection, 2.5 months after the onset of the infection. The relapse is discussed taking into account the mechanism of action of ACV, the age of the patient and the immunological response profile. Because of the high risk of neurological involvement, we suggest that the relapse should be treated with ACV for a period of time longer than actually recommended.
authors.affiliation: Service de pédiatrie B, hôpital Saint-Vincent-de-Paul, Paris, France.
authors.forename: M A
authors.initials: MA
authors.lastname: Le Gall
authors.forename: J F
authors.initials: JF
authors.lastname: Boccara
authors.forename: C
authors.initials: C
authors.lastname: Francoual
authors.forename: M
authors.initials: M
authors.lastname: Houang
authors.forename: P
authors.initials: P
authors.lastname: Lebon
authors.forename: J
authors.initials: J
authors.lastname: Badoual
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use*; D000284:Administration, Oral; D006561:Herpes Simplex / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D007275:Injections, Intravenous; D008297:Male; D012008:Recurrence; D012874:Skin Diseases, Infectious / Q000188:drug therapy*
chemical_list: D000212:Acyclovir
vernacular_title: Herpès néonatal: rechute après traitement par acyclovir.