title: Detection of human papillomavirus DNA in seborrheic keratosis by polymerase chain reaction.
abstract: We searched for HPV DNA in 72 cases of seborrheic keratosis (nongenital SK 29, genital SK 43) using polymerase chain reaction. Amplification of HPV DNA was found in 24 (nongenital, 1; genital, 23). HPV DNA type 6 was present in 18 cases and type 11 in four and type 33 in two. Twenty-three (53%) cases of genital region SK and one (3%) case of nongenital region SK contained HPV DNA sequences. Histopathologically, the perinuclear vacuolization of epithelial cells, mitosis and dyskeratotic cells were more marked in HPV DNA-positive SK than those in negative SK (P < 0.01). We suppose HPV may play an important role in epidermal proliferation of SK in the genital region.
authors.affiliation: Department of Dermatology, Nanjing Medical College, People's Republic of China.
authors.forename: W Y
authors.initials: WY
authors.lastname: Zhu
authors.forename: C
authors.initials: C
authors.lastname: Leonardi
authors.forename: N S
authors.initials: NS
authors.lastname: Penneys
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001483:Base Sequence; D015344:DNA Probes, HPV; D004279:DNA, Viral / Q000235:genetics* / Q000302:isolation & purification; D005260:Female; D005835:Genitalia / Q000382:microbiology; D006801:Humans; D017492:Keratosis, Seborrheic / Q000382:microbiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D027383:Papillomaviridae / Q000235:genetics* / Q000302:isolation & purification; D016133:Polymerase Chain Reaction
chemical_list: D015344:DNA Probes, HPV; D004279:DNA, Viral