[Sidnofen-dependent pre- and postsynaptic activation of peripheral adrenergic transmission].
The psychostimulant sydnophen causes a spontaneous activity and increases contractile responses evoked by noradrenaline (NA) and field stimulation in rat vas deferens. The effects of the agent are independent of its ability to inhibit MAO activity. The sydnophen-induced spontaneous activity is blocked not only by alpha-adrenoceptor antagonists such as phentolamine and prazosin, but by guanethidine that blocks presynaptic neuronal NA release. Analysis of dose-response NA action has indicated that sydnophen enhances adrenoceptor sensitivity (the dissociation constant changes from 10.10(-6) M to 2.7.10(-6) M). Experimental findings suggest that sydnophen has activating presynaptic and postsynaptic action.
Babskaia
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D000818:Animals; D000928:Antidepressive Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004558:Electric Stimulation; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects* / Q000502:physiology; D013558:Sydnones / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology; D014649:Vas Deferens / Q000187:drug effects / Q000294:innervation / Q000502:physiology
D000928:Antidepressive Agents; D011941:Receptors, Adrenergic; D013558:Sydnones; C013271:sydnophen
Sidnofenzavisimaia pre- i postsinapticheskaia aktivatsiia perifericheskoĭ adrenergicheskoĭ peredachi.