[A pharmacological analysis of the role of GABA- and opioidergic systems in the development of brain edema].
Opioid receptors blocker naloxone potentiated edematous effect of GABA-receptors blockers in experiments on rats. In combination with bicuculline and picrotoxine that agent leads to increased content of water in the brain and decreased brain tissue density. At the same time naloxone prevented GABA-antagonists activation of oxidative processes in brain mitochondria.
Novikov
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VE
Iasnetsov
V V
VV
Sharov
A N
AN
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D001929:Brain Edema / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D009270:Naloxone / Q000494:pharmacology; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000502:physiology; D011957:Receptors, Opioid / Q000187:drug effects* / Q000502:physiology; D012663:Semicarbazides / Q000494:pharmacology
D001640:Bicuculline; D009270:Naloxone; D010852:Picrotoxin; D011963:Receptors, GABA-A; D011957:Receptors, Opioid; D012663:Semicarbazides; C005151:thiosemicarbazide
Farmakologicheskiĭ analiz roli GAMK- i opioidergicheskikh sistem v razvitii oteka golovnogo mozga.