[Psychosine-induced changes in neuromuscular transmission and in the structure of the neuromuscular junction in the frog].
A decrease in the amplitude of miniature and evoked end-plate potentials (MEPPs and EPPs) as well as changes in EPP facilitation and depression during frequency stimulation were observed in psychosine-treated m. cutaneous-pectoris of the frog. Electron-microscopic investigation demonstrated severe changes in synaptic Schwann cells embracing motor terminals and disturbances in the inner mesaxon structure of the myelinated parts of motor terminals.
Vinogradova
I M
IM
Dobretsov
M G
MG
Tomilin
N V
NV
D000818:Animals; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D008854:Microscopy, Electron; D009469:Neuromuscular Junction / Q000187:drug effects*; D011609:Psychosine / Q000494:pharmacology*; D011898:Ranidae; D012583:Schwann Cells / Q000187:drug effects / Q000648:ultrastructure; D013569:Synapses / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects*
D011609:Psychosine
Vyzyvaemye psikhozinom izmeneniia nervno-myshechnoĭ peredachi i struktury nervno-myshechnogo soedineniia u liagushki.