Lymphosarcoma in experimentally induced feline immunodeficiency virus infection [corrected].
A cat experimentally infected with feline immunodeficiency virus (FIV) but known to be free of feline leukaemia virus (FeLV) developed lymphosarcoma. The lesions in the liver and kidneys were present nine months after infection, when the cat was 21 months old. The cat had no overt signs of immunodeficiency and it is suggested that the B cell activation induced shortly after FIV infection produced a large pool of proliferating lymphocytes from which the malignant cells emerged.
Callanan
J J
JJ
Department of Veterinary Pathology, University of Glasgow, Bearsden.
McCandlish
I A
IA
O'Neil
B
B
Lawrence
C E
CE
Rigby
M
M
Pacitti
A M
AM
Jarrett
O
O
D000818:Animals; D002415:Cats; D016181:Feline Acquired Immunodeficiency Syndrome / Q000150:complications*; D016089:Immunodeficiency Virus, Feline; D007668:Kidney / Q000473:pathology; D007680:Kidney Neoplasms / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D008297:Male