Lipid-independent therapeutic properties of transdermal 17 B-estradiol on cardiovascular diseases.
A low dose of transdermally administered 17 B-estradiol promptly improved a severe, treatment-unresponsive, cardiac arrhythmia initiated after the menopause in a woman with type-II familial hyperlipoproteinemia. The same treatment normalized the hypertension initiated after ovariectomy, in a woman who was only poorly controlled by anti-hypertensive drugs. These two cases are the first clear report of cardiovascular therapeutic properties of transdermal estradiol via mechanisms independent of lipoprotein modifications.
Cagnacci
A
A
Istituto di Clinica Ostetrica e Ginecologica, Ospedale S. Giovanni di Dio, Gagliari, Italy.
Soldani
R
R
Puccini
E
E
Fioretti
P
P
Melis
G B
GB
D000279:Administration, Cutaneous; D000328:Adult; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D004958:Estradiol / Q000494:pharmacology* / Q000627:therapeutic use; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008055:Lipids / Q000097:blood; D008875:Middle Aged
D008055:Lipids; D004958:Estradiol