Angiotensin II rapidly modulates the renal peripheral benzodiazepine receptor.
The effects of acute exposure to angiotensin II (AII) on the renal peripheral benzodiazepine receptor were studied in rats. As little as 37.5 micrograms of AII injected s.c. over an 80 min period caused immediate reductions in [3H]Ro5-4864 binding. Scatchard analysis revealed that the reduction in [3H]Ro5-4864 binding induced by AII was due to a drop in receptor density or Bmax. The influence of AII on the peripheral benzodiazepine receptor is similar to that of stress.
Holmes
P V
PV
Schrier Research Laboratory, Department of Psychology, Brown University, Providence, RI 02912.
Drugan
R C
RC
D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D001570:Benzodiazepinones / Q000378:metabolism; D001667:Binding, Competitive / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000502:physiology*
D001570:Benzodiazepinones; D011963:Receptors, GABA-A; D000804:Angiotensin II; C028513:4'-chlorodiazepam; D009638:Norepinephrine