title: Analgosedation raises baroreflex sensitivity in acute myocardial ischaemia.
abstract: Acute local myocardial ischaemia is associated with a decrease in baroreflex sensitivity while electrical instability (vulnerability) of ventricles increases. Co-administration of a benzodiazepine and a potent analgesic (analgosedation) has been found to raise both baroreflex sensitivity and ventricular fibrillation threshold. Pharmacological modulation of neurovegetative ionization of the heart in the early phase of ischaemia is a promising method for preventing sudden coronary death.
authors.affiliation: Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
authors.forename: M
authors.initials: M
authors.lastname: Vrána
authors.forename: Z
authors.initials: Z
authors.lastname: Fejfar
authors.forename: L
authors.initials: L
authors.lastname: Hess
authors.forename: Z
authors.initials: Z
authors.lastname: Blazek
mesh_terms: D000818:Animals; D017704:Baroreflex / Q000187:drug effects* / Q000502:physiology; D016292:Procedural Sedation; D004285:Dogs; D004562:Electrocardiography / Q000187:drug effects; D005283:Fentanyl; D006352:Heart Ventricles / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D008874:Midazolam; D017202:Myocardial Ischemia / Q000503:physiopathology*
chemical_list: D008874:Midazolam; D005283:Fentanyl