[Effects of nitroxyl radicals on pathogenic properties of herpesvirus (the spin-label technique in the study of virus-macrophage interactions)].
The effect of various concentrations of both methyl ether of 5-doxyl-stearic acid (M5DS) and 4-maleimido-TEMPO (4MT) on the pathogenicity of herpes simplex virus (HSV-1) was studied. It is known that the reagents modify the lipid matrix and the proteins of virion envelope. The decrease of the HSV-1 pathogenicity was shown when using the concentration of reagents more 5 x 10(-5) M. HSV-1 having high pathogenicity and cytotoxicity was obtained when the concentrations of the reagents were less 5 x 10(-5) M.
Gorbunov
N V
NV
Nasyrov
R A
RA
Erin
A N
AN
Ivanova
V P
VP
Taros
L Iu
LIu
D000818:Animals; D002478:Cells, Cultured; D003497:Cyclic N-Oxides / Q000494:pharmacology*; D003588:Cytopathogenic Effect, Viral; D008264:Macrophages / Q000382:microbiology*; D051379:Mice; D008808:Mice, Inbred CBA; D018139:Simplexvirus / Q000187:drug effects* / Q000472:pathogenicity; D013057:Spectrum Analysis; D013113:Spin Labels
D003497:Cyclic N-Oxides; D013113:Spin Labels; C017480:4-maleimido-2,2,6,6-tetramethylpiperidinooxyl; C005072:5-doxylstearic acid
Vliianie nitroksil'nykh radikalov na patogennye svoĭstva virusa Gerpesa (metod spinovogo zondirovaniia v issledovanii vzaimodeĭstviia virus-makrofag).