Expressions of receptor gene for hepatocyte growth factor in kidney after unilateral nephrectomy and renal injury.
The renal expressions of the receptor gene (c-met) for hepatocyte growth factor (HGF) were examined in unilateral nephrectomy (UNX), renal ischemia or folic acid administration. The levels of c-met mRNA were increased rapidly in all rat models at 6h after the operations. On the other hand, the expression of c-met mRNA in a kidney cell line (MDCK cells) was down-regulated for 8 h after HGF addition, indicating that c-met mRNA induction in rat models may be independent of the stimulated production of HGF. The stimulated expression of c-met in these models suggest that HGF may play an important role in renal hypertrophy after UNX and regeneration after ischemic or nephrotoxic injury.
Ishibashi
K
K
Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
Sasaki
S
S
Sakamoto
H
H
Hoshino
Y
Y
Nakamura
T
T
Marumo
F
F
D000818:Animals; D005492:Folic Acid / Q000494:pharmacology; D015870:Gene Expression / Q000187:drug effects; D017228:Hepatocyte Growth Factor / Q000494:pharmacology*; D007511:Ischemia / Q000235:genetics; D007668:Kidney / Q000098:blood supply / Q000293:injuries / Q000502:physiology*; D008297:Male; D009392:Nephrectomy; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D019859:Proto-Oncogene Proteins c-met; D011519:Proto-Oncogenes; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D011956:Receptors, Cell Surface / Q000235:genetics*; D013997:Time Factors
D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D017228:Hepatocyte Growth Factor; D005492:Folic Acid; D019859:Proto-Oncogene Proteins c-met