Evidence for tachykinin NK-2B-like receptors in guinea-pig alveolar macrophages.
Mammalian tachykinins dose-dependently activate guinea-pig alveolar macrophages, by interacting with tachykinin NK-2 receptors, mainly. By evaluating the effects of different NK-2 tachykinin receptor antagonists, we now provide evidence that tachykinin NK-2 receptors in guinea-pig alveolar macrophages meet the pharmacological criteria used to define the NK-2B subtype.
Brunelleschi
S
S
Dept. Pharmacology, Univ. Florence, Firenze, Italy.
Ceni
E
E
Fantozzi
R
R
Maggi
C A
CA
D000595:Amino Acid Sequence; D000818:Animals; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008262:Macrophage Activation / Q000502:physiology; D016676:Macrophages, Alveolar / Q000378:metabolism*; D008969:Molecular Sequence Data; D017981:Receptors, Neurotransmitter / Q000037:antagonists & inhibitors / Q000145:classification* / Q000502:physiology; D018039:Receptors, Tachykinin; D015320:Tachykinins / Q000037:antagonists & inhibitors / Q000502:physiology*
D017981:Receptors, Neurotransmitter; D018039:Receptors, Tachykinin; D015320:Tachykinins