[The Askin tumor].
The Askin tumor, a primitive malignant small-cell tumor of the chest wall, is mostly seen among children and adolescents. It is closely related to Ewing's sarcoma of the same location, both tumors showing a chromosomal translocation t(11;22). Its origin from neuroectodermal cells is deducted from several ultrastructural details and from the expression of specific markers like NSE. Pain and deformation of the chest wall are the cardinal clinical signs of the tumor. Chest X-rays will frequently show destruction of ribs and pleural effusions. Effective therapy consists of radical surgery, local radiation and adjuvant chemotherapy. This multimodal concept allows minority of patients to remain disease-free but the overall outcome is rather unfortunate.
Sarkar
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Abteilung Allgemein- und Thoraxchirurgie, Städtischen Klinikums Karlsruhe.
Bähr
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D000328:Adult; D018288:Carcinoma, Small Cell / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D003131:Combined Modality Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D016609:Neoplasms, Second Primary / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D013117:Spinal Cord Compression / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D013125:Spinal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D013899:Thoracic Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D013904:Thoracic Vertebrae / Q000528:radiation effects / Q000601:surgery
Der Askin-Tumor.