Seizures associated with ganciclovir therapy.
A 32-year-old man diagnosed with acquired immunodeficiency syndrome and a disseminated cytomegalovirus infection experienced seizures associated with the administration of ganciclovir. Seizures began 1 month after initiation of therapy and worsened with increasing dosages. Despite phenytoin administration, the seizure-like activity subsided only after discontinuing ganciclovir. After rechallenge with ganciclovir the seizures recurred. Although this case was confounded by numerous patient and disease factors, the Naranjo algorithm produced a score of 7, indicating a probable association between ganciclovir and seizure activity.
Barton
T L
TL
Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284-7766.
Roush
M K
MK
Dever
L L
LL
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D003586:Cytomegalovirus Infections / Q000150:complications; D015774:Ganciclovir / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D012173:Retinitis / Q000150:complications / Q000188:drug therapy; D012640:Seizures / Q000139:chemically induced*
D015774:Ganciclovir