Taurine induces bicuculline/strychnine-insensitive dose-dependent inhibition of cortical visual evoked responses.
Modulatory influences of taurine on cortical visual evoked responses and their susceptibility to GABAergic and glycinergic antagonists were studied in adult rats. Taurine topically administered to the visual cortex produced dose-dependent inhibition of the positive-negative fast component of the cortical visual evoked responses. Neither bicuculline nor strychnine antagonized the taurine effect, as revealed by absence of a shift to right, a change in slope or in the taurine IC50 value in the dose-response curve. Results suggest that taurine-induced depression of cortical responses evoked in the visual cortex are mediated by receptors other than the GABAA and glycine receptors.
Cañas
P
P
Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago.
Hernández
A
A
Pérez
H
H
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005074:Evoked Potentials, Visual / Q000187:drug effects* / Q000502:physiology; D005998:Glycine / Q000502:physiology; D009433:Neural Inhibition / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013331:Strychnine / Q000494:pharmacology*; D013654:Taurine / Q000494:pharmacology* / Q000502:physiology; D014793:Visual Cortex / Q000187:drug effects* / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D013654:Taurine; D005680:gamma-Aminobutyric Acid; D013331:Strychnine; D005998:Glycine; D001640:Bicuculline