[Macrophage activation syndrome and dysgammaglobulinemia. Role of the Epstein-Barr virus].
The case of a five-year-old boy with macrophage activation syndrome and Epstein-Barr virus infection is reported. Several unusual features were found, including an early major increase in IgA levels, persistent oligoclonal gammapathy, and delayed development of anti-EA antibodies accompanied with an increase in anti-VCA antibodies. Despite the negative family history, an immune deficit and Purilo syndrome are discussed as possible diagnoses in this child.
François
B
B
Unité d'Hématologie et d'Oncologie Pédiatrique, Hôpital Trousseau, Paris.
Gouraud
F
F
Garbarg-Chenon
A
A
Despretz
P
P
Leverger
G
G
D015139:Blotting, Southern; D002675:Child, Preschool; D004854:Herpesvirus 4, Human; D006801:Humans; D006942:Hypergammaglobulinemia / Q000097:blood / Q000209:etiology* / Q000276:immunology; D007070:Immunoglobulin A; D008262:Macrophage Activation; D008297:Male; D014412:Tumor Virus Infections / Q000097:blood / Q000150:complications* / Q000276:immunology
D007070:Immunoglobulin A
Syndrome d'activation macrophagique et dysgammaglobulinémie. Rôle du virus d'Epstein-Barr.