Absence of maternal behavior in rats with lithium/pilocarpine seizure-induced brain damage: support of MacLean's triune brain theory.
Female rats, with and without maternal experience, received limbic seizure-inducing (SC) injections of lithium and pilocarpine. Following the subsequent parturitions, these rats displayed a complete absence of maternal behavior. Rats that did not display seizures after receiving the lithium/pilocarpine injections displayed behaviors that were comparable to normal controls. Although the multifocal limbic, thalamic, and cingulate damage abolished maternal care, there was no evidence of aberrant effects upon fecundity, litter size, or mammary function; infanticide was negligible. The pattern of brain damage involves the evolutionarily more recent thalamocingulate system of mammals and supports MacLean's theory that these pathways are required for normal mother-offspring interaction.
Peredery
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Behavioral Neuroscience Laboratory, Laurentian University, Sudbury, Ontario, Canada.
Persinger
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MA
Blomme
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Parker
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G
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000187:drug effects; D002712:Chlorides / Q000494:pharmacology*; D004569:Electroencephalography / Q000187:drug effects*; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology; D007696:Kindling, Neurologic / Q000187:drug effects* / Q000502:physiology; D008032:Limbic System / Q000187:drug effects / Q000502:physiology; D008094:Lithium / Q000494:pharmacology*; D018021:Lithium Chloride; D008425:Maternal Behavior; D009410:Nerve Degeneration / Q000187:drug effects* / Q000502:physiology; D010862:Pilocarpine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D002712:Chlorides; D010862:Pilocarpine; D008094:Lithium; D018021:Lithium Chloride