Effect of Sp-cAMP on sperm motility in patients with unexplained infertility.
Sperm motility is one of the most important semen parameters affecting the fertility of an individual. Sp-cAMP, a thiophosphate analogue of c-AMP, is a phosphodiesterase inhibitor controlling the intracellular c-AMP levels which in turn influences sperm motility. The results in our laboratory on a group of suspected subfertile men and fertile donors showed significant enhancement of sperm motility after incubation of washed sperm with various doses of Sp-cAMP.
Agarwal
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Division of Urological Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Loughlin
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KR
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors; D000242:Cyclic AMP / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005298:Fertility; D006801:Humans; D066298:In Vitro Techniques; D007248:Infertility, Male / Q000503:physiopathology*; D008297:Male; D012016:Reference Values; D013081:Sperm Motility / Q000187:drug effects*; D013873:Thionucleotides / Q000494:pharmacology*
D013873:Thionucleotides; C016957:adenosine-3',5'-cyclic phosphorothioate; D000242:Cyclic AMP; D015105:3',5'-Cyclic-AMP Phosphodiesterases