[The effect of splenectomy on the immune status of children with active liver cirrhosis].
A complex study of parameters of the systemic cell humoral immunity, secretory immune system, functional state and phagocytic activity of neutrophils as well as activity of the complement and its C3, C4 components in 28 children with active cirrhosis of the liver has shown that the disease was accompanied by a generalized disturbance of the immunity mechanisms. Splenectomy in these children was shown to have favorable influence on the immune status, to reduce activity of the immunopathological process in the liver. At the same time, splenectomy results in continuous suppression of neutrophilic phagocytosis which may be a cause of the development of postsplenectomy septic conditions.
Mikhaĭlova
Z M
ZM
Gafarov
O
O
Leont'ev
A F
AF
Chistova
L V
LV
D000293:Adolescent; D000917:Antibody Formation; D002648:Child; D002908:Chronic Disease; D006801:Humans; D006975:Hypertension, Portal / Q000276:immunology / Q000601:surgery; D007111:Immunity, Cellular; D007113:Immunity, Innate; D008103:Liver Cirrhosis / Q000276:immunology* / Q000601:surgery; D013154:Spleen / Q000276:immunology*; D013156:Splenectomy
Vliianie splenéktomii na immunnyĭ status deteĭ s aktivnym tsirrozom pecheni.