title: The physiological role of estradiol 17-sulfate during pregnancy.
abstract: To clarify the physiological role of estradiol 17-sulfate (ES) during pregnancy, experiments were conducted and the following results were obtained: (1) serum or urinary ES levels rose as a function of gestational age; (2) placental microsomes showed fairly high 2- and 4-hydroxylase activity for ES; and (3) the catechol products, 2- and 4-hydroxy-ES, had a strong inhibitory effect upon the in vitro production of lipid peroxides. These results suggest that ES acts as a precursor to the catechol metabolites which maintain normal gestation. This is coincident with the negative correlation of serum levels in ES and lipid peroxides observed in late pregnancy.
authors.affiliation: Hokkaido Institute of Pharmaceutical Sciences, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Yoshizawa
authors.forename: K
authors.initials: K
authors.lastname: Takanashi
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: H
authors.initials: H
authors.lastname: Honjo
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: N
authors.initials: N
authors.lastname: Sakuragi
authors.forename: S
authors.initials: S
authors.lastname: Fujimoto
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004958:Estradiol / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000652:urine; D004966:Estrogens, Conjugated (USP) / Q000378:metabolism*; D005260:Female; D006801:Humans; D006900:Hydroxylation; D008054:Lipid Peroxides / Q000097:blood; D008861:Microsomes / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy / Q000502:physiology*; D013739:Testosterone / Q000378:metabolism
chemical_list: D004966:Estrogens, Conjugated (USP); D008054:Lipid Peroxides; C048615:estradiol 17-sulfate; D013739:Testosterone; D004958:Estradiol