Structure and evolution of insulins: implications for receptor binding.
Insulin is a member of a family of hormones, growth factors and neuropeptides which are found in both vertebrates and invertebrates. A common 'insulin fold' is probably adopted by all family members. Although the specificities of receptor binding are different, there is a possibility of co-evolution of polypeptides and their receptors.
Murray-Rust
J
J
Laboratory of Molecular Biology, Birkbeck College, London, UK.
McLeod
A N
AN
Blundell
T L
TL
Wood
S P
SP
D001665:Binding Sites; D005075:Biological Evolution; D006133:Growth Substances / Q000737:chemistry; D007328:Insulin / Q000737:chemistry*; D009479:Neuropeptides / Q000737:chemistry; D011972:Receptor, Insulin / Q000737:chemistry*; D011956:Receptors, Cell Surface / Q000737:chemistry
D006133:Growth Substances; D007328:Insulin; D009479:Neuropeptides; D011956:Receptors, Cell Surface; D011972:Receptor, Insulin