In vitro activity of l-ofloxacin against norfloxacin-resistant coagulase-negative staphylococci.
The in vitro activity of l-ofloxacin was determined against coagulase-negative staphylococci that were induced to norfloxacin resistance. l-Ofloxacin was the most active agent tested with an MIC90 of 4 micrograms/ml compared with greater than 128, 32, and 128 micrograms/ml for norfloxacin, ciprofloxacin, and enoxacin, respectively. Rifampin-resistant, coagulase-negative staphylococci were not cross-resistant to the quinolones tested. Among the rifampin-resistant organisms tested, l-ofloxacin was also the most active agent with an MIC90 of 0.25 micrograms/ml.
Foleno
B
B
Microbiology Research, R.W. Johnson Pharmaceutical Research Institute, Raritan, New Jersey 08869.
Fu
K P
KP
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003030:Coagulase / Q000378:metabolism; D004352:Drug Resistance, Microbial; D008826:Microbial Sensitivity Tests; D009643:Norfloxacin / Q000494:pharmacology*; D015242:Ofloxacin / Q000494:pharmacology*; D015363:Quinolones / Q000494:pharmacology; D013210:Staphylococcus / Q000187:drug effects* / Q000201:enzymology
D000900:Anti-Bacterial Agents; D003030:Coagulase; D015363:Quinolones; D015242:Ofloxacin; D009643:Norfloxacin