Four cases with intrafamilial clustering of hepatitis C virus infection.
Four hepatitis C patients with intrafamilial clustering of hepatitis C virus (HCV) infection are reported. Antibodies to C100-3 antigen, capsid protein of HCV and GOR epitope were tested to detect histories of HCV infection. Transmission of HCV from mother to children, from father to children, and from wife to husband was implicated. Of all family members studied, three were positive for all antibodies, one for only antibody to capsid protein, two for antibodies to capsid protein and GOR epitope but negative for antibody to C100-3 antigen and one vice versa.
Takahashi
M
M
First Department of Internal Medicine, Okayama University Medical School, Japan.
Yamada
G
G
Doi
T
T
Endo
H
H
Nishimoto
H
H
Takaguchi
K
K
Matsueda
K
K
Fujiki
S
S
Mizuno
M
M
Kinoyama
S
S
D000328:Adult; D015415:Biomarkers; D016000:Cluster Analysis; D005260:Female; D016174:Hepacivirus / Q000276:immunology; D006508:Hepatitis Antibodies / Q000097:blood; D006526:Hepatitis C / Q000453:epidemiology* / Q000276:immunology / Q000635:transmission*; D006801:Humans; D008297:Male; D008875:Middle Aged
D015415:Biomarkers; D006508:Hepatitis Antibodies