Tcrb-V3+ T-cell deletion and a new mouse mammary tumor provirus, Mtv-44.
Genes encoding endogenous superantigens causing Tcrb-V3+ T-cell deletion co-segregate with mouse mammary tumor proviruses (Mtv), Mtv-3, Mtv-6, and Mtv-13. In addition Mtv-1 has been implicated in deletion of these T cells. We have examined levels of Tcrb-V3+ T cells and Mtv integrations in the following offspring and their parental strains, [(CBA-T6 x NZW)F1 x CBA], [(CBA x C3H/He)F1 x CBA], and [(B10.S (9R) x NOD]F1 mice. We show that a new Mtv (Mtv-44) from NZW mice and Mtv-1 from C3H/He mice cosegregate with genes encoding ligands for partial deletion of Tcrb-V3+ T cells and that some NOD mice have an additional Mtv (Mtv-45) which is closely linked to Mtv-3.
Fairchild
S
S
Transplantation Biology Section, MRC Clinical Research Centre, Harrow, Middlesex, England.
Rosenwasser
O A
OA
Dyson
P J
PJ
Tomonari
K
K
D000818:Animals; D000956:Antigens, Viral / Q000235:genetics*; D015139:Blotting, Southern; D002872:Chromosome Deletion; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D008024:Ligands; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics* / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D011533:Proviruses / Q000235:genetics; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*; D013601:T-Lymphocytes / Q000502:physiology*
D000956:Antigens, Viral; D008024:Ligands; D016693:Receptors, Antigen, T-Cell, alpha-beta