A comparison of itraconazole and griseofulvin in the treatment of tinea corporis and tinea cruris: a double-blind study.
A total of 40 patients with clinically and mycologically documented tinea corporis or tinea cruris were treated with 100 mg/day itraconazole (n = 19) or 500 mg/day griseofulvin (n = 21) for 15 days. Of the itraconazole-treated patients, 83.3% were healed or markedly improved, i.e. 'responders', after 15 days compared with 85.7% of griseofulvin-treated patients. At 15 days after the end of treatment, 88.2% of itraconazole- and 80.9% of griseofulvin-treated patients were classed as 'responders'. The mycological cure rate (both microscopy and culture negative) was generally lower than the clinical response rate. Both treatments were equally effective at the end of 15 days' treatment with 66.7% of patients cured, but itraconazole was superior to griseofulvin at the 15-day follow-up visit (77.8% of itraconazole-treated patients compared with 66.7% of griseofulvin-treated patients were cured). Both therapies were well tolerated; only one patient treated with itraconazole reported minor side-effects (dizziness, headache and gastro-intestinal disturbances). The results confirm those of earlier comparative trials and suggest that griseofulvin-treated patients are more at risk of relapse than are itraconazole-treated patients.
Panagiotidou
D
D
Department of Dermatology, University of Thessaloniki, Greece.
Kousidou
T
T
Chaidemenos
G
G
Karakatsanis
G
G
Kalogeropoulou
A
A
Teknetzis
A
A
Chatzopoulou
E
E
Michailidis
D
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006118:Griseofulvin / Q000627:therapeutic use*; D006801:Humans; D017964:Itraconazole; D007654:Ketoconazole / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D013045:Species Specificity; D014005:Tinea / Q000188:drug therapy* / Q000382:microbiology; D014249:Trichophyton / Q000302:isolation & purification
D000935:Antifungal Agents; D017964:Itraconazole; D006118:Griseofulvin; D007654:Ketoconazole