Mechanisms of action of sodium channel blocker: gate-related receptor hypothesis.
A new hypothesis on mechanisms of action of the sodium channel blocker, the gate-related receptor hypothesis, has been proposed in this paper. Furthermore, a mathematic model and parameter estimation procedure for the kinetics analysis have also been given. Using the model and procedure, modeling and analyzing of cardiac sodium channel blockade by lidocaine and dauricine have been performed. The model-estimated results were not only coincident with those documented, but also provided some new information which may be helpful for understanding mechanism of blocking action of both drugs on sodium channels. The studies suggested that the gate-related receptor hypothesis is good for the elucidation of mechanisms of action of the sodium channel blocker.
Wu
Y J
YJ
Department of Pharmacology, Tongji Medical University, Wuhan, PRC.
Fang
D C
DC
D000470:Alkaloids; D044182:Benzylisoquinolines; D003198:Computer Simulation; D015640:Ion Channel Gating; D007546:Isoquinolines / Q000494:pharmacology; D008012:Lidocaine / Q000494:pharmacology; D008956:Models, Chemical; D015222:Sodium Channels / Q000187:drug effects*; D044005:Tetrahydroisoquinolines
D000470:Alkaloids; D044182:Benzylisoquinolines; D007546:Isoquinolines; D015222:Sodium Channels; D044005:Tetrahydroisoquinolines; C035934:dauricine; D008012:Lidocaine