title: Deblocking effect of TRH-T in three cases of chronic progressive multifocal neuropathy.
abstract: Three cases of acquired demyelinating multifocal neuropathy with persistent conduction blocks are reported. In one of them protyreline tartrate (TRH-T) had an evident deblocking effect; similar but milder effects were seen in the other two cases. The course and consistency of this effect is analyzed on the grounds of clinical and electromyographic findings. The nature of the THR-T responsive conduction block is analysed as a mild variant of CIDP with regard to its occurrence in a late and chronic phase without signs of active immune processes.
authors.affiliation: Department of Neurology, University of Milan, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Pinelli
authors.forename: F
authors.initials: F
authors.lastname: Pisano
authors.forename: G
authors.initials: G
authors.lastname: Miscio
authors.forename: F
authors.initials: F
authors.lastname: Ceriani
mesh_terms: D000328:Adult; D003711:Demyelinating Diseases / Q000188:drug therapy*; D004576:Electromyography / Q000187:drug effects; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008475:Median Nerve / Q000187:drug effects; D008875:Middle Aged; D009132:Muscles / Q000294:innervation; D009460:Neurologic Examination / Q000187:drug effects*; D009468:Neuromuscular Diseases / Q000188:drug therapy*; D010292:Paresthesia / Q000188:drug therapy*; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy*; D011930:Reaction Time / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects*; D013973:Thyrotropin-Releasing Hormone / Q000627:therapeutic use*; D014459:Ulnar Nerve / Q000187:drug effects
chemical_list: D013973:Thyrotropin-Releasing Hormone