The rate of DNA damage and aging.
A new theory of aging based on the rate of DNA damage is presented, and the relationship between the rate of oxidative DNA damage and maximum life span (MLS) of mammalian species is explored. In humans the level of oxidative DNA damage, as measured by urinary biomarkers, can be modulated by caloric restriction and dietary composition. Consequently, longevity may depend not only on the basal metabolic rate but also on dietary caloric intake and the type of diet. The theory may provide the basis for a practical approach for reduction of degenerative diseases in general, extension of life expectancy, and optimization of individual lifestyles.
Simic
M G
MG
Department of Pharmacology and Toxicology, School of Pharmacy, University of Maryland, Baltimore 21201.
D000375:Aging / Q000502:physiology*; D000818:Animals; D004249:DNA Damage; D002149:Energy Intake; D005609:Free Radicals; D006801:Humans; D006878:Hydroxides / Q000378:metabolism; D017665:Hydroxyl Radical; D007700:Kinetics; D008954:Models, Biological
D005609:Free Radicals; D006878:Hydroxides; D017665:Hydroxyl Radical