[Changes in activity of G-6-pase, APase, and gamma-GTPase in liver and blood serum of rats exposed to nuarimol and NDEA].
The effect of simultaneous administration of N-diethylnitrosamine (NDEA) and Nuarimol on the activity of gamma-GTPase, G-6-Pase ans APase in the liver and serum of Wistar rats was investigated in the 2-weeks experiment. The two-stage hepato-cancerogenesis model was used with NDEA as initiating agent. The possible promoting potential of Nuarimol (DDT analogue) was checked in this experiment. gamma-GTPase and G-6-Pase activities were measured by biochemical and histochemical methods and AP-ase activity was measured by a biochemical method only. The occurrence of gamma-GTPase positive foci found by histochemical methods was partly confirmed by colorimetric methods. This suggest the need for further examination of this enzyme in conditions of prolonged exposure to Nuarimol.
Wiadrowska
B
B
Zakładu Toksykologii Srodowiskowej Państwowego Zakładu Higieny, Warszawie.
Ludwicki
J K
JK
Palut
D
D
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D004052:Diethylnitrosamine / Q000633:toxicity*; D005260:Female; D005659:Fungicides, Industrial / Q000633:toxicity*; D020558:GTP Phosphohydrolases / Q000378:metabolism; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D011743:Pyrimidines / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
D005659:Fungicides, Industrial; D011743:Pyrimidines; D004052:Diethylnitrosamine; D000469:Alkaline Phosphatase; D005952:Glucose-6-Phosphatase; D020558:GTP Phosphohydrolases; C067672:nuarimol
Zmiany aktywności G-6-Pazy, Apazy i gamma-GTPazy w watrobie i surowicy krwi szczurów narazonych na nuarimaol i NDEA.