title: Detection of human herpesvirus 6 in tissues involved by sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease).
abstract: After preliminary serologic data demonstrated elevated antibody titers to human herpesvirus (HHV) 6 in patients with sinus histiocytosis with massive lymphadenopathy (SHML) or Rosai-Dorfman disease, tissues were examined from 9 patients with classical SHML to search for evidence of HHV-6 infection. Involved tissues from 7 of the 9 patients had detectable HHV-6 by in situ hybridization: Tissue from 1 had detectable Epstein-Barr virus genome but no HHV-6 and tissue from another had no detectable HHV-6 or Epstein-Barr virus. These studies suggest that HHV-6 and, to a lesser extent, Epstein-Barr virus may be involved in the etiology of SHML.
authors.affiliation: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
authors.forename: P H
authors.initials: PH
authors.lastname: Levine
authors.forename: N
authors.initials: N
authors.lastname: Jahan
authors.forename: P
authors.initials: P
authors.lastname: Murari
authors.forename: M
authors.initials: M
authors.lastname: Manak
authors.forename: E S
authors.initials: ES
authors.lastname: Jaffe
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D002460:Cell Line; D015654:Herpesvirus 6, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D015618:Histiocytosis, Sinus / Q000382:microbiology*; D006801:Humans; D007124:Immunoenzyme Techniques; D009693:Nucleic Acid Hybridization
chemical_list: D000914:Antibodies, Viral