[The effect of acute alcoholization on the neuronal activity of the normal ventromedial hypothalamus and in pharmacological actions on the brain monoaminergic and opiate systems].
In experiments on white outbred male rats the specificity was studied of the influence and mechanisms of action of acute alcoholization (30%-solution of ethanol, intraperitoneally, 0.7 g/kg) on the activity of functionally different neurones of the ventromedial hypothalamus. Experimental results showed that the neurones, the activity of which lowered after saturation (I-st type), increased the discharges frequency at administration of ethanol. Nerve cells, the activity of which increased (II-nd type) and did not change (III-nd type) after saturation, had inhibitory character of reaction in response to alcoholization. The increase of serotonin content in the brain elicited by intraperitoneal administration of 5-OTPh (50 mg/kg) blockaded the action of ethanol on the nerve cells of the I-st type and did not change the effect of the alcohol on the neurones of the II-nd and III-nd types. Preliminary lowering of the noradrenaline level in the brain (disulphiram, intraperitoneally, 100 mg/kg) and blockade of opiate receptors (nalorphine, 5 mg/kg) fully eliminated ethanol influence on the activity of all types of neurones.
Gasanov
G G
GG
Kuliev
E I
EI
Agaeva
T F
TF
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000435:Alcoholic Intoxication / Q000503:physiopathology*; D000818:Animals; D004221:Disulfiram / Q000494:pharmacology; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology; D007033:Hypothalamus, Middle / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D009269:Nalorphine / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects* / Q000502:physiology; D011957:Receptors, Opioid / Q000187:drug effects* / Q000502:physiology; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000502:physiology
D011941:Receptors, Adrenergic; D011957:Receptors, Opioid; D011985:Receptors, Serotonin; D000431:Ethanol; D006916:5-Hydroxytryptophan; D004221:Disulfiram; D009269:Nalorphine
Vliianie ostroĭ alkogolizatsii na neĭronnuiu aktivnost' ventromedial'nogo gipotalamusa v norme i pri farmakologicheskikh vozdeĭstviiakh na monoaminergicheskie i opiatnuiu sistemy mozga.