[The lithium carbonate promotion of urothelial tumors in rats induced with N-butyl-N-(4-hydroxybutyl)-nitrosamine].
The effect of lithium carbonate on promotion of N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced bladder tumors in rats was studied. Lithium carbonate acted as promoter in bladder carcinogenesis resulting in a 6-fold increase in the tumor occurrence as compared to controls. The experiments with sequential injection of the agent showed its promoting effect to be most apparent within 3-6 months following exposure to the carcinogen.
Frolov
A G
AG
Pliss
G B
GB
D000818:Animals; D002085:Butylhydroxybutylnitrosamine / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D016651:Lithium Carbonate / Q000633:toxicity*; D008297:Male; D051381:Rats; D013997:Time Factors; D001743:Urinary Bladder / Q000187:drug effects / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000473:pathology
D002273:Carcinogens; D016651:Lithium Carbonate; D002085:Butylhydroxybutylnitrosamine
Promotsiia karbonatom litiia urotelial'nykh opukholeĭ u krys, indutsirovannykh N-butil-N-(4-gidrokisbutil)-nitrozaminom.