A study of nerve conduction velocity in patients on diphenylhydantoin therapy.
Peripheral nerve conduction studies were performed in 30 epileptics, treated with DPH and results were compared with age and sex matched controls. There was significant reduction in the amplitude of sensory nerve action potential of median (26.65 +/- 14.71 mu v) and superficial radial nerve (25.65 +/- 10.08 mu v) (p < 0.001) in DPH treated group as compared to controls, (median nerve 42.64 +/- 15.93 uv and superficial radial nerve 40.72 +/- 24.74 mu v). The results suggest that DPH causes a subclinical distal axonal neuropathy in therapeutic dosage.
Mehrotra
T N
TN
Dept. of Medicine, L L R M Medical College, Meerut.
Srivastava
S S
SS
Goel
V K
VK
Sood
K
K
Singh
V S
VS
Jain
A K
AK
D000200:Action Potentials / Q000187:drug effects; D004827:Epilepsy / Q000188:drug therapy; D006801:Humans; D009046:Motor Neurons / Q000187:drug effects*; D009431:Neural Conduction / Q000187:drug effects*; D009475:Neurons, Afferent / Q000187:drug effects*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced; D010672:Phenytoin / Q000009:adverse effects* / Q000494:pharmacology; D013997:Time Factors
D010672:Phenytoin