title: Interaction of amyloid beta protein (25-35) with tachykinin receptors.
abstract: Amyloid beta protein (25-35) failed to significantly interact with tachykinin NK1 (rat forebrain, guinea-pig ileum) NK2 (rabbit pulmonary artery, hamster trachea) or NK-3 (guinea-pig cortex) receptors, as determined by radioligand binding and functional assays. A weak interaction (Ki 14.8 microM) was detected with NK2 receptors in rat small intestine. It appears unlikely that direct interaction with tachykinin receptors may account for the reported ability of amyloid beta protein (25-35) to affect neuronal survival.
authors.affiliation: Pharmacology and Chemistry Department, A. Menarini Pharmaceuticals, Florence, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Rovero
authors.forename: R
authors.initials: R
authors.lastname: Patacchini
authors.forename: A R
authors.initials: AR
authors.lastname: Renzetti
authors.forename: M
authors.initials: M
authors.lastname: Brown
authors.forename: J
authors.initials: J
authors.lastname: Mizrahi
authors.forename: C A
authors.initials: CA
authors.lastname: Maggi
authors.forename: A
authors.initials: A
authors.lastname: Giachetti
mesh_terms: D000595:Amino Acid Sequence; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D006168:Guinea Pigs; D007082:Ileum / Q000378:metabolism; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000378:metabolism*; D016548:Prosencephalon / Q000378:metabolism; D011651:Pulmonary Artery / Q000378:metabolism; D051381:Rats; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D018039:Receptors, Tachykinin; D015320:Tachykinins / Q000378:metabolism*; D014132:Trachea / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; D017981:Receptors, Neurotransmitter; D018039:Receptors, Tachykinin; D015320:Tachykinins; C074636:amyloid beta-protein (25-35)