title: V1-receptor mediated GSH efflux by vasopressin from rat hepatocytes.
abstract: Vasopression increases sinusoidal efflux of GSH in the perfused rat liver. The mechanism of this effect was studied in the perfused rat liver and in isolated rat hepatocytes. Vasopressin stimulated GSH efflux in both systems and a V1-receptor antagonist (OPC-21268) significantly inhibited the effect of vasopressin suggesting that vasopressin stimulates GSH efflux from rat hepatocytes via V1-receptor.
authors.affiliation: Division of Health Science, Faculty of Medicine, Tokyo Medical and Dental University, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Sato
authors.forename: J H
authors.initials: JH
authors.lastname: Liu
authors.forename: M
authors.initials: M
authors.lastname: Uchihara
authors.forename: N
authors.initials: N
authors.lastname: Izumi
authors.forename: T
authors.initials: T
authors.lastname: Yauchi
authors.forename: Y
authors.initials: Y
authors.lastname: Sakaj
authors.forename: Y
authors.initials: Y
authors.lastname: Asahina
authors.forename: T
authors.initials: T
authors.lastname: Fukuma
authors.forename: T
authors.initials: T
authors.lastname: Takano
authors.forename: F
authors.initials: F
authors.lastname: Marumo
mesh_terms: D057911:Angiotensin Receptor Antagonists; D000818:Animals; D001692:Biological Transport; D002478:Cells, Cultured; D005978:Glutathione / Q000378:metabolism*; D006003:Glycogen / Q000378:metabolism; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010880:Piperidines / Q000494:pharmacology; D015363:Quinolones / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011945:Receptors, Angiotensin / Q000378:metabolism*; D017483:Receptors, Vasopressin; D014667:Vasopressins / Q000502:physiology*
chemical_list: D057911:Angiotensin Receptor Antagonists; D010880:Piperidines; D015363:Quinolones; D011945:Receptors, Angiotensin; D017483:Receptors, Vasopressin; D014667:Vasopressins; C068644:OPC 21268; D006003:Glycogen; D005978:Glutathione