Recurrent adult nephroblastoma. Long-term remission after surgery plus adjuvant high-dose chemotherapy, radiation therapy, and allogeneic bone marrow transplantation.
The authors report a case of Stage IV, unfavorable histologic type adult nephroblastoma. The patient was treated with multimodal therapy: combination chemotherapy consisting of cyclophosphamide, doxorubicin, cisplatin, and etoposide succeeded by nephrectomy and radiation therapy. After a disease-free period of 27 months, a pararectal relapse was treated by surgery, high-dose chemotherapy, and allogeneic bone marrow transplantation (BMT). The patient is alive and disease-free 3.5 years after BMT.
Hupperets
P S
PS
Department of Internal Medicine, Academic Hospital Maastricht, The Netherlands.
Havenith
M G
MG
Blijham
G H
GH
D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage; D016026:Bone Marrow Transplantation; D017024:Chemotherapy, Adjuvant; D006801:Humans; D007680:Kidney Neoplasms / Q000628:therapy*; D008297:Male; D012074:Remission Induction / Q000379:methods; D014184:Transplantation, Homologous; D009396:Wilms Tumor / Q000556:secondary* / Q000628:therapy*
D000970:Antineoplastic Agents