The role of reactive oxygen species in the pathogenesis of multiple sclerosis.
Although reactive oxygen species are thought to mediate cellular damage in many disease states the role of reactive oxygen species in the pathogenesis of multiple sclerosis is unknown. Data from biochemical, histochemical and pharmacological studies have been evaluated to determine if the necessary conditions exist for the formation of reactive oxygen species during a demyelination episode of multiple sclerosis. This evaluation found that not only do the necessary conditions exist for the formation of reactive oxygen species but that these species may play a significant pathogenic role in this disease. A hypothesis describing a detailed role of reactive oxygen species in the pathogenesis of multiple sclerosis is put forth.
LeVine
S M
SM
Department of Physiology, University of Kansas Medical Center, Kansas City 66160.
D005609:Free Radicals; D006801:Humans; D006878:Hydroxides / Q000378:metabolism; D017665:Hydroxyl Radical; D007501:Iron / Q000378:metabolism; D008954:Models, Biological; D009103:Multiple Sclerosis / Q000209:etiology* / Q000378:metabolism; D009186:Myelin Sheath / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*
D005609:Free Radicals; D006878:Hydroxides; D017382:Reactive Oxygen Species; D017665:Hydroxyl Radical; D007501:Iron