Complexoproductive and antiheparin properties of low density lipoproteins (LDL). I. Interaction of isolated low density lipoproteins with heparin of different molecular weight.
Low density lipoproteins/LDL/ form unsoluble complexes with heparin of different molecular weight in the presence of CaCl2. Quantity of the complexes depends on molecular weight of heparin, concentration of reagents and pH of the reacting medium. The biggest quantity of complexes result from LDL-heparin of the molecular weight 16000, the quantity is smaller with heparin of the molecular weight 5100 and the quantity is smallest with heparin of the molecular weight 3700. Components of LDL--heparin complexes are bound by means of ion and hydrogen bonds.
Skrzydlewski
Z
Z
Department of Instrumental Analysis, Medical University of Bialystok.
Rółkowski
R
R
Worowski
K
K
Lukaszuk
C
C
D002122:Calcium Chloride / Q000008:administration & dosage / Q000494:pharmacology; D004347:Drug Interactions; D019791:Guanidine; D006146:Guanidines / Q000008:administration & dosage / Q000494:pharmacology; D006493:Heparin / Q000008:administration & dosage / Q000494:pharmacology*; D006494:Heparin Antagonists; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007202:Indicators and Reagents / Q000008:administration & dosage / Q000494:pharmacology; D008077:Lipoproteins, LDL / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D008970:Molecular Weight; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology; D014508:Urea / Q000008:administration & dosage / Q000494:pharmacology
D006146:Guanidines; D006494:Heparin Antagonists; D006495:Heparin, Low-Molecular-Weight; D007202:Indicators and Reagents; D008077:Lipoproteins, LDL; C062642:low density lipoprotein-heparin complex; D012965:Sodium Chloride; D014508:Urea; D006493:Heparin; D019791:Guanidine; D002122:Calcium Chloride