title: Focal liver disease: comparison of dynamic contrast-enhanced CT and T2-weighted fat-suppressed, FLASH, and dynamic gadolinium-enhanced MR imaging at 1.5 T.
abstract: Dynamic contrast medium-enhanced computed tomography (CT), T2-weighted fat-suppressed spin-echo (T2FS) magnetic resonance (MR) imaging, and breath-hold T1-weighted fast low-angle shot (FLASH) MR imaging before and after dynamic gadopentetate dimeglumine injection were compared in 73 patients with clinically suspected liver disease. Observer confidence for presence of focal lesions was determined by using receiver operating characteristic analysis. For all MR images, hepatic lesion-liver signal-to-noise ratios were evaluated qualitatively. and resolution and presence of artifacts were evaluated qualitatively. Lesion detection was greatest with T2FS (n = 272) and enhanced FLASH (n = 244) and was statistically greater with both of these than with CT (n = 220) and FLASH (n = 219) (P less than .03). Correct lesion characterization was greatest with enhanced FLASH (n = 236) (P less than .01), followed by CT (n = 199), FLASH (n = 164), and T2FS (n = 144). Enhanced FLASH was particularly successful in characterization of 5-mm- to 1.5-cm-diameter lesions as cystic or solid.
authors.affiliation: Department of Radiology, St Boniface General Hospital MRI Facility, Winnipeg, Man., Canada.
authors.forename: R C
authors.initials: RC
authors.lastname: Semelka
authors.forename: J P
authors.initials: JP
authors.lastname: Shoenut
authors.forename: M A
authors.initials: MA
authors.lastname: Kroeker
authors.forename: H M
authors.initials: HM
authors.lastname: Greenberg
authors.forename: F C
authors.initials: FC
authors.lastname: Simm
authors.forename: G Y
authors.initials: GY
authors.lastname: Minuk
authors.forename: R M
authors.initials: RM
authors.lastname: Kroeker
authors.forename: A B
authors.initials: AB
authors.lastname: Micflikier
mesh_terms: D000236:Adenoma / Q000175:diagnosis; D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis; D003560:Cysts / Q000175:diagnosis; D005260:Female; D005682:Gadolinium; D006391:Hemangioma / Q000175:diagnosis; D006801:Humans; D007089:Image Enhancement; D008107:Liver Diseases / Q000175:diagnosis*; D008113:Liver Neoplasms / Q000175:diagnosis / Q000556:secondary; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D005682:Gadolinium