[Membrane mechanisms of testosterone action].
The experiments on adult Wistar rats have shown that testosterone administration provoke hyperpolarization of hepatocytes and adrenocorticocytes plasmatic membranes. It was discovered that this hyperpolarization was caused by cell Na, K-ATPase activation. Inhibitors of protein biosynthesis prevent both testosterone-induced hyperpolarization and Na, K-ATPase activation. It is shown that some hyperpolarization factor appeared in the cytosol and blood serum under testosterone influence. It was suggested that this mechanism is mediated by cell genome.
Frol'kis
V V
VV
Kobzar'
A L
AL
Tiukhtin
G M
GM
D000302:Adrenal Cortex / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects*; D004789:Enzyme Activation; D066298:In Vitro Techniques; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone; D000254:Sodium-Potassium-Exchanging ATPase
Membrannye mekhanizmy deĭstviia testosterona.