Diazepam antagonizes effects on dopamine metabolism produced by PCP receptor agonists.
1. Male rats were injected with either saline, diazepam, MK-801, or diazepam plus MK-801. 2. In previous work with phencyclidine (PCP), diazepam significantly reduced the increase in homovanillic acid (HVA) in olfactory tubercle and prefrontal cortex. 3. Diazepam also lowered the HVA increase following MK-801 in caudate, olfactory tubercle, and prefrontal cortex. 4. Benzodiazepine receptors may modify dopaminergic function at PCP receptors that affect dopamine neurotransmission.
Bowers
M B
MB
Department of Psychiatry, Yale University, New Haven, CT.
Morton
J B
JB
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology*; D016291:Dizocilpine Maleate / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D006719:Homovanillic Acid / Q000378:metabolism; D008297:Male; D010622:Phencyclidine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051381:Rats; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology*; D017478:Receptors, Phencyclidine
D017981:Receptors, Neurotransmitter; D017478:Receptors, Phencyclidine; D016291:Dizocilpine Maleate; D010622:Phencyclidine; D003975:Diazepam; D004298:Dopamine; D006719:Homovanillic Acid