[The effect of gamma irradiation on the structure and enzymatic activity of the nuclear membrane of the liver in pregnant rats and their embryos].
Morphological and biochemical investigations of pregnant rats and embryo liver cell nuclei after in vivo irradiation in the doses of 1 and 2 Gr revealed their high radiosensitivity at all stages of gestation and embryonal development. At damaging effect of radiation, we managed to observe sharp accumulation of products of lipid peroxide oxidation and suppression of the activities of such enzymes as cytochrome-c-oxidase, NAD.N-cytochrome-c-reductase, ATPase and RNAase in liver nuclei of pregnant rats and embryos. The changes of such a kind are shown to intensify with the increasing of irradiation doses. The most profound inhibition of the activities of these enzymes in liver nuclei of embryos irradiated in utero was observed during the period of organogenesis (the 13th day of the development) and in fetal period of embryogenesis (the 17th day of the development), as well as at the 13th and 17th day of gestation. The morphological data also demonstrate the high level of cell nucleus sensitivity to the action of radiation during gestation and embryogenesis.
Mirakhmedov
A K
AK
Mirkhamidova
P
P
Shamsutdinova
G T
GT
Filatova
L S
LS
Khamidov
D Kh
DKh
Zbarskiĭ
I B
IB
D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism / Q000528:radiation effects; D002467:Cell Nucleus / Q000201:enzymology / Q000528:radiation effects* / Q000648:ultrastructure; D003576:Electron Transport Complex IV / Q000378:metabolism / Q000528:radiation effects; D004622:Embryo, Mammalian / Q000201:enzymology / Q000528:radiation effects* / Q000648:ultrastructure; D005260:Female; D005720:Gamma Rays; D015227:Lipid Peroxidation / Q000528:radiation effects; D008099:Liver / Q000201:enzymology / Q000528:radiation effects* / Q000648:ultrastructure; D008854:Microscopy, Electron; D009245:NADH Dehydrogenase / Q000378:metabolism / Q000528:radiation effects; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000528:radiation effects*; D051381:Rats; D012260:Ribonucleases / Q000378:metabolism / Q000528:radiation effects; D013997:Time Factors
D009245:NADH Dehydrogenase; D003576:Electron Transport Complex IV; D012260:Ribonucleases; D017301:Ca(2+) Mg(2+)-ATPase
Vliianie gamma-oblucheniia na strukturu i fermentativnuiu aktivnost' iadernoĭ obolochki pecheni beremennykh krys i ikh émbrionov.