Inhibitory effect of the leukotriene B4 receptor antagonist against hypomagnesic diet-induced dermatitis in hairless rats.
In vivo experiments have shown that magnesium deficiency elicits characteristic skin lesions in the hairless rat. However, the mechanism of the involvement is not clarified. From the results of previous studies, a product derived from arachidonic acid, but not via the cyclooxygenase pathway, has been considered as an etiological cause. In this study, the inhibitory effect of newly produced leukotriene B4 (LTB4) receptor antagonist (LTBRA) against these skin manifestation was examined in hairless mutants given a hypomagnesic diet. Control animals with treatment of LTBRA developed eruptions on their bodies with increasing serum levels of LTB4, but LTBRA-treated animals did not suffer from the cutaneous disorder. Increased serum levels of LTB4 in control rats were significantly higher than those in the pre-treated condition. The diminution of skin lesions by LTBRA strongly indicated that magnesium deficiency dermatitis may involve a lipoxygenase-mediated metabolite of arachidonic acid, presumably LTB4, and that the cutaneous changes in hairless rats fed with hypomagnesic diet might provide an easily identifiable indicator of LTB4-mediated dermatitis.
Hanada
K
K
Department of Dermatology, Hirosaki University School of Medicine, Japan.
Mitsuhashi
Y
Y
Hashimoto
I
I
D000818:Animals; D005260:Female; D007975:Leukotriene B4; D008275:Magnesium Deficiency / Q000150:complications*; D010666:Phenylpropionates / Q000494:pharmacology*; D051381:Rats; D011923:Rats, Nude; D011971:Receptors, Immunologic / Q000037:antagonists & inhibitors* / Q000502:physiology*; D018102:Receptors, Leukotriene B4; D012871:Skin Diseases / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*
D010666:Phenylpropionates; D011971:Receptors, Immunologic; D018102:Receptors, Leukotriene B4; C067523:ONO-LB 457; D007975:Leukotriene B4