Concentration of plasminogen activators and inhibitor in the human endometrium at different phases of the menstrual cycle.
The concentrations of tissue plasminogen activator (t-PA), urokinase plasminogen activator (u-PA) and plasminogen activator inhibitor (PAI-1) have been determined in endometrial curettings obtained from 46 subfertile women during proliferative, early or late secretory phases of the menstrual cycle. t-PA activity and antigen concentrations was significantly higher (P < 0.001) in late secretory endometrium than in proliferative or early secretory endometrium. Higher concentrations of PAI-1 antigen (P < 0.05) were also noted in late secretory phase than in proliferative and early secretory endometrium. However, u-PA concentration was not significantly different and no PAI activity could be demonstrated in the menstrual phases studied. Zymography studies confirmed the presence of both t-PA and u-PA in the endometrium. Ovarian hormonal patterns may therefore influence the activity of plasminogen activators especially of t-PA in the endometrium during various phases of the menstrual cycle.
Koh
S C
SC
Department of Obstetrics and Gynaecology, National University of Singapore, National University Hospital.
Wong
P C
PC
Yuen
R
R
Chua
S E
SE
Ng
B L
BL
Ratnam
S S
SS
D000328:Adult; D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D005498:Follicular Phase / Q000378:metabolism; D006801:Humans; D007247:Infertility, Female / Q000378:metabolism*; D008183:Luteal Phase / Q000378:metabolism; D008297:Male; D008597:Menstrual Cycle / Q000378:metabolism*; D017395:Plasminogen Activator Inhibitor 1 / Q000096:biosynthesis*; D010960:Plasminogen Activators / Q000096:biosynthesis*; D011817:Rabbits; D010959:Tissue Plasminogen Activator / Q000096:biosynthesis; D014568:Urokinase-Type Plasminogen Activator / Q000096:biosynthesis
D017395:Plasminogen Activator Inhibitor 1; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator