Syntheses of leukotriene-derivatives.
Some general synthetic routes for the synthesis of cysteinyl-leukotriene derivatives derived from stable building blocks are described. D6-LTE4, a metabolically stable isotopically labelled mass spectrometric internal standard, 20-hydroxy-LTE4, the unnatural 6-epi-LTE4; LTE3, a LT-derivative with 2-amino-thiophenol as a modified "amino-acid" and 14,15-dehydro-LTA4 were prepared. The compounds were tested in a LT-inhibition assay using a monoclonal antibody.
Bestmann
H J
HJ
Institute of Organic Chemistry, University of Erlangen-Nürnberg, FRG.
Röder
T
T
D003903:Deuterium; D017572:Leukotriene A4; D017999:Leukotriene E4; D015289:Leukotrienes / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D015394:Molecular Structure; D013189:SRS-A / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry
D017572:Leukotriene A4; D015289:Leukotrienes; D013189:SRS-A; D017999:Leukotriene E4; D003903:Deuterium