title: [Iron absorption in HbH disease].
abstract: We have reported that many cases of Hb H disease have a complication of iron overload without a history of multiple blood transfusion or prolonged iron therapy. We determined their iron absorption by 59Fe whole body counting in 13 such cases. Also 10 normal subjects were studied as a control group. The results showed a significant increase in iron absorption to 20.3%, in contrast to 6.9% in the normal control. This was further documented by their RBC incorporation (i.e. the percentage of orally administered) 59Fe recovered in the total RBC mass) on day 14 (13.7% vs 6.1%). The degree of ineffective erythropoiesis might not be severe considering their similar 59Fe utilization by RBC (i.e. the percentage of absorbed 59Fe recovered in the RBC) to the normals (86.3% vs. 84.3%).
authors.affiliation: Department of Medicine, Veterans General Hospital, Taipei.
authors.forename: C K
authors.initials: CK
authors.lastname: Lin
authors.forename: J S
authors.initials: JS
authors.lastname: Lin
authors.forename: S Y
authors.initials: SY
authors.lastname: Chen
authors.forename: J G
authors.initials: JG
authors.lastname: Lo
authors.forename: C C
authors.initials: CC
authors.lastname: Chien
authors.forename: R S
authors.initials: RS
authors.lastname: Liu
authors.forename: M C
authors.initials: MC
authors.lastname: Jiang
authors.forename: S H
authors.initials: SH
authors.lastname: Lee
mesh_terms: D000042:Absorption; D005260:Female; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008297:Male; D013789:Thalassemia / Q000378:metabolism*
chemical_list: D007501:Iron