title: Physical dependence on diazepam: precipitation of abstinence syndromes by peripheral and central benzodiazepine receptor antagonists.
abstract: This work was performed to compare withdrawal symptoms induced by the administration of the central vs. peripheral benzodiazepine antagonists in rats treated chronically with diazepam (15 mg/kg, SC) for 8 days. Withdrawal was expressed as motor, autonomic, and behavioral signs. Significant withdrawal occurred after the administration of both flumazenil (15 and 20 mg/kg, IP) and PK11195 (5 and 10 mg/kg, IP). With these doses, PK11195 induced diarrhea and decreased motor activity more than did flumazenil. These preliminary results suggest that peripheral benzodiazepine receptors are involved in the withdrawal syndrome in diazepam-dependent rats.
authors.affiliation: Department of Physiology and Pharmacology, Faculty of Medicine, Espinardo, Murcia, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Martinez
authors.forename: M J
authors.initials: MJ
authors.lastname: Fargeas
authors.forename: L
authors.initials: L
authors.lastname: Bueno
mesh_terms: D000818:Animals; D003975:Diazepam / Q000008:administration & dosage / Q000009:adverse effects*; D058787:GABA-A Receptor Antagonists; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects; D013375:Substance Withdrawal Syndrome; D019966:Substance-Related Disorders
chemical_list: D058787:GABA-A Receptor Antagonists; D011963:Receptors, GABA-A; D003975:Diazepam