Correlation of serum metalloproteinase levels with lung cancer metastasis and response to therapy.
Cancer cells elaborate metalloproteinases which may play a role in invasion and metastasis. The serum level of the M(r) 72,000 type IV collagenase (MMP-2) was measured in 87 lung cancer patients. Stage IV cancer levels were significantly elevated (P less than 0.0001) compared to normal sera. A significant difference (P less than 0.01) was found between enzyme levels in the presence versus the absence of distant metastasis. For 29 patients treated with combination chemotherapy, a positive relationship was noted between response failure and elevated enzyme levels. Serum metalloproteinase levels may provide information relevant to prognosis as well as treatment decisions.
Garbisa
S
S
Histology Institute, Padova University, Italy.
Scagliotti
G
G
Masiero
L
L
Di Francesco
C
C
Caenazzo
C
C
Onisto
M
M
Micela
M
M
Stetler-Stevenson
W G
WG
Liotta
L A
LA
D014408:Biomarkers, Tumor / Q000097:blood*; D018288:Carcinoma, Small Cell / Q000097:blood / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology; D020780:Matrix Metalloproteinase 9; D003012:Microbial Collagenase / Q000097:blood*; D009362:Neoplasm Metastasis
D014408:Biomarkers, Tumor; D003012:Microbial Collagenase; D020780:Matrix Metalloproteinase 9