title: Effect of phosphatidylinositol-specific phospholipase C from Bacillus thuringiensis on solid spinocellular carcinoma.
abstract: Phosphatidylinositol-specific phospholipase C (PIPLC) from Bacillus thuringiensis (0.11 units per ml) inhibited growth of IC-Sofia carcinoma cell line in culture by 64%. The growth of transplanted carcinoma in hamsters was also inhibited by 29% at a dose of 4.9 units of PIPLC/kg animal/day. In addition, degeneration processes and a significant fibrosis of the tumour occurred. The functional, clinical, biochemical and haematological parameters studied were consistent with the established antitumour effect in vivo.
authors.affiliation: Department of Physiology, Institute of Medicine, Plovdiv, Bulgaria.
authors.forename: D
authors.initials: D
authors.lastname: Sarafov
authors.forename: B
authors.initials: B
authors.lastname: Trifonov
authors.forename: A
authors.initials: A
authors.lastname: Ivanov
authors.forename: E
authors.initials: E
authors.lastname: Kamberov
authors.forename: Z
authors.initials: Z
authors.lastname: Zaprjanov
authors.forename: P
authors.initials: P
authors.lastname: Pavlov
authors.forename: E
authors.initials: E
authors.lastname: Georgieva
mesh_terms: D000818:Animals; D001413:Bacillus thuringiensis / Q000201:enzymology*; D002455:Cell Division / Q000187:drug effects*; D006224:Cricetinae; D008297:Male; D008647:Mesocricetus; D009368:Neoplasm Transplantation; D043265:Phosphatidylinositol Diacylglycerol-Lyase; D054801:Phosphoinositide Phospholipase C; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D010727:Phosphoric Diester Hydrolases; D054801:Phosphoinositide Phospholipase C; D043265:Phosphatidylinositol Diacylglycerol-Lyase