Biochemical correlates of alpha 1-adrenoceptor activation.
An impressive body of evidence based on radioligand binding, biochemical, functional and structural data supports the existence of two sub-types of the alpha 1-adrenoceptor (alpha 1a and alpha 1b) in the CNS and in peripheral tissues. Both elevate intracellular Ca2+ concentrations, although by different mechanisms, resulting in a cascade of intracellular events dependent upon the cell type involved.
Kendall
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Department of Physiology and Pharmacology, University of Nottingham Medical School, Queen's Medical Centre, U.K.
D000818:Animals; D003001:Cloning, Molecular; D000242:Cyclic AMP / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism; D010741:Phospholipases A / Q000378:metabolism; D011942:Receptors, Adrenergic, alpha / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction
D010716:Phosphatidylinositols; D011942:Receptors, Adrenergic, alpha; D000242:Cyclic AMP; D010741:Phospholipases A