title: Pattern of 2-deoxy-2-[18F]-fluro-D-glucose accumulation in liver tumours: primary, metastatic and after chemotherapy.
abstract: Eight patients with liver metastases from adenocarcinoma of the colon or rectum, two with suspected hepatic metastases and one with primary hepatoma were studied with 2-deoxy-2-[18F]-fluro-D-glucose (18F-FDG) using positron emission tomography (PET). In five of the patients with metastatic tumour a second examination was performed four weeks after treatment with recombinant interleukin-2 (rIL2) and fluorouracil (5FU). In all tumours (one primary and eight metastatic) the radioactivity was seen to accumulate in a rim around each tumour with a large central area showing no uptake. In the five cases imaged after treatment with rIL2, the appearance of the tumour uptake was the same as before treatment. In the two cases of suspected but not proven metastases, no abnormal accumulation of 18F-FDG was seen.
authors.affiliation: Department of Nuclear Medicine, Aberdeen Royal Infirmary, Foresterhill, UK.
authors.forename: F W
authors.initials: FW
authors.lastname: Smith
authors.forename: S D
authors.initials: SD
authors.lastname: Heys
authors.forename: N T
authors.initials: NT
authors.lastname: Evans
authors.forename: D
authors.initials: D
authors.lastname: Roeda
authors.forename: D
authors.initials: D
authors.lastname: Gvozdanovic
authors.forename: O
authors.initials: O
authors.lastname: Eremin
authors.forename: J R
authors.initials: JR
authors.lastname: Mallard
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary*; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000188:drug therapy; D003110:Colonic Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D003847:Deoxyglucose / Q000031:analogs & derivatives; D019788:Fluorodeoxyglucose F18; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D007376:Interleukin-2 / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000556:secondary; D011994:Recombinant Proteins; D012004:Rectal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D014055:Tomography, Emission-Computed
chemical_list: D007376:Interleukin-2; D011994:Recombinant Proteins; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose; D005472:Fluorouracil