Acute effects of cadmium on the renin angiotensin system in rats.
The effect of cadmium acetate (1 mg/kg i.p.) on the renin angiotensin system was examined in male Sprague-Dawley rats. Blood pressure, plasma renin activity (PRA) and serum angiotensin converting enzyme (ACE) levels were determined in the rats. Cadmium acetate produced a hypertensive response which was not associated with elevated PRA. However, ACE levels in the serum were significantly decreased in the cadmium-treated group as compared with normal controls (P less than 0.01).
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Division of Pharmacology, Central Drug Research Institute, Lucknow, India.
D000085:Acetates; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000633:toxicity; D000818:Animals; D001794:Blood Pressure; D002104:Cadmium / Q000633:toxicity*; D006973:Hypertension / Q000139:chemically induced; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects*
D000085:Acetates; D000806:Angiotensin-Converting Enzyme Inhibitors; D002104:Cadmium; C028031:cadmium acetate; D007703:Peptidyl-Dipeptidase A; D012083:Renin