Kininogenase activity of rSMT3, a rat submandibular gland tonin.
rSMT3, a tonin like angiotensin II generating enzyme present in rSMG presents a potent oxytocic effect on the isolated rat uterus, which was blocked by a B2 bradykinin receptor antagonist. Under optimal conditions of pH, rSMT3 liberates kinin at rate 19-fold greater than angiotensin II.
Araujo
G W
GW
Department of Physiology and Biophysics, Universidade Federal de Minas Gerais, Belo Horizonte; São Paulo, Brazil.
Silva
A M
AM
Pesquero
J B
JB
Lindsey
C J
CJ
Beraldo
W T
WT
Pesquero
J L
JL
D000804:Angiotensin II / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D001681:Biological Assay; D001794:Blood Pressure / Q000187:drug effects; D001920:Bradykinin / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D005260:Female; D066298:In Vitro Techniques; D007610:Kallikreins / Q000378:metabolism*; D007700:Kinetics; D007704:Kininogens / Q000494:pharmacology; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012504:Saralasin / Q000494:pharmacology; D013363:Submandibular Gland / Q000201:enzymology*; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000187:drug effects / Q000502:physiology
D007704:Kininogens; D000804:Angiotensin II; D007703:Peptidyl-Dipeptidase A; D007610:Kallikreins; D012504:Saralasin; D001920:Bradykinin