title: Dietary gamma-linolenic acid lowers blood pressure and alters aortic reactivity and cholesterol metabolism in hypertension.
abstract: OBJECTIVE
  To determine the effects of dietary gamma-linolenic acid upon blood pressure, aortic reactivity and cholesterol metabolism in spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats.
  
  
  METHODS
  Randomized parallel-group study.
  
  
  METHODS
  SHR and WKY rats were fed a purified diet containing either sesame or borage oil rich in gamma-linolenic acid for 7 weeks. Blood pressure measured by the tail-cuff method and weight were monitored weekly. At the end of the study, intra-arterial pressor responses to norepinephrine and angiotensin II, and reactivity of isolated aortic rings to norepinephrine, angiotensin II, KCl and acetylcholine were determined. Serum cholesterol and triglycerides were measured. Hepatic and intestinal enzymes and receptors of cholesterol metabolism were also measured.
  
  
  RESULTS
  Dietary borage oil significantly decreased blood pressure in SHR and WKY rats compared with sesame oil-fed rats. Pressor responses to norepinephrine and angiotensin II, and aortic reactivity to norepinephrine, angiotensin II, KCl and acetylcholine were not significantly different. The borage oil diet increased serum cholesterol levels in WKY rats and hepatic B-hydroxy-3-methylglutaryl coenzyme A reductase in SHR.
  
  
  CONCLUSIONS
  These data indicate that dietary borage oil has a blood pressure lowering effect in hypertensive and normotensive rats. However, the effect cannot be explained by altered sensitivity to humoral and neural vasoconstrictors or changes in cholesterol metabolism. Other mechanisms should be investigated.
authors.affiliation: Department of Physiological Nursing, University of California, San Francisco 94134-0610.
authors.forename: M M
authors.initials: MM
authors.lastname: Engler
authors.forename: M B
authors.initials: MB
authors.lastname: Engler
authors.forename: S K
authors.initials: SK
authors.lastname: Erickson
authors.forename: S M
authors.initials: SM
authors.lastname: Paul
mesh_terms: D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D001011:Aorta / Q000187:drug effects*; D001786:Blood Glucose / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects*; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage / Q000494:pharmacology*; D004573:Electrolytes / Q000097:blood; D006973:Hypertension / Q000178:diet therapy* / Q000378:metabolism; D008042:Linolenic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000502:physiology; D010938:Plant Oils / Q000494:pharmacology* / Q000627:therapeutic use; D011897:Random Allocation; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012715:Sesame Oil / Q000494:pharmacology* / Q000627:therapeutic use; D014280:Triglycerides / Q000097:blood; D017965:gamma-Linolenic Acid
chemical_list: D001786:Blood Glucose; D004042:Dietary Fats, Unsaturated; D004573:Electrolytes; D008042:Linolenic Acids; D010938:Plant Oils; D014280:Triglycerides; D000804:Angiotensin II; D017965:gamma-Linolenic Acid; D012715:Sesame Oil; D002784:Cholesterol; D009638:Norepinephrine