[erb-B oncogene in human oral squamous cell carcinomas].
erb-B gene is an oncogene from avian leukosis virus. The carcinogenic capability of erb-B is due to the close similarity of expressional proteins to the epidermal growth factor receptor (EGFr). In this study the amplification and the over-expression of erb-B were found in human oral squamous (cell carcinomas by DNA and RNA dot blot hybridization). Results showed that erb-B was correlated with the oral epidermoid tumors but not with group of non-epidermoid tumors in the head and neck region. Southern blotting analysis showed that there were rearrangement of erb-B gene in the tumor genosomes, which is perhaps one of the ways to activate the proto-oncogene of erb-B.
Li
B
B
Wang
M
M
Wen
Y
Y
Chen
J
J
D001354:Avian Leukosis Virus / Q000235:genetics; D015139:Blotting, Southern; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D004273:DNA, Neoplasm / Q000032:analysis; D066246:ErbB Receptors; D006801:Humans; D009062:Mouth Neoplasms / Q000235:genetics*; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics*
D004273:DNA, Neoplasm; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D066246:ErbB Receptors