Brain Na+ K+ ATPase and cholesterol in acute experimental trypanosomiasis.
Brain Na+ K+ ATPase activity has been found to decrease in experimental trypanosomiasis in rats infected with Trypanosoma congolense. Some physical features that affect membrane fluidity were also observed to be altered. The levels of cholesterol in the brain and free fatty acids in the serum were found to increase in the infected animals. These findings might be relevant to the development of brain lesions.
Nok
A J
AJ
Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria.
Esievo
K A
KA
Ukoha
A I
AI
Ikediobi
C O
CO
Ibrahim
S
S
Martins
O
O
Tekdek
B
B
Omage
J
J
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood; D008297:Male; D008560:Membrane Fluidity; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013816:Thermodynamics; D014348:Trypanosoma congolense; D014353:Trypanosomiasis, African / Q000378:metabolism*
D005230:Fatty Acids, Nonesterified; D002784:Cholesterol; D000254:Sodium-Potassium-Exchanging ATPase