title: Syntenic assignments of visual transduction genes in cattle.
abstract: To establish syntenic relationships of phototransduction genes, we have mapped the genes encoding the alpha-, beta-, and gamma-subunits of rod cGMP phosphodiesterase (PDE) (PDEA, PDEB, PDEG), the alpha'-subunit of cone PDE (PDEA2), and the rod cGMP-gated channel (CNCG) to bovine syntenic groups. The rod cGMP PDE alpha-, beta-, and gamma-subunit genes map to bovine syntenic groups U22, U15 (chromosome 6), and U21 (chromosome 19), respectively. The rod cGMP-gated channel gene also maps to syntenic group U15, and the bovine cone alpha'-subunit gene maps to U26 (chromosome 26). With the exception of the cone PDE alpha'-subunit gene, which has not been mapped in other mammals, all of these genes have been assigned to conserved chromosomal regions shared among bovine, human, and mouse. A compilation of currently known syntenic assignments and predictions regarding future assignments of phototransduction genes in human, mouse, and cattle is presented.
authors.affiliation: Department of Veterinary Pathobiology, Texas A&M University, College Station 77843-4463.
authors.forename: D S
authors.initials: DS
authors.lastname: Gallagher
authors.forename: J E
authors.initials: JE
authors.lastname: Womack
authors.forename: W
authors.initials: W
authors.lastname: Baehr
authors.forename: S J
authors.initials: SJ
authors.lastname: Pittler
mesh_terms: D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern / Q000662:veterinary; D002417:Cattle / Q000235:genetics*; D002874:Chromosome Mapping; D054815:Cyclic Nucleotide-Gated Cation Channels; D004277:DNA, Single-Stranded; D005136:Eye Proteins / Q000235:genetics*; D006801:Humans; D007473:Ion Channels; D008969:Molecular Sequence Data; D010775:Photic Stimulation; D010786:Photoreceptor Cells / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics*; D014785:Vision, Ocular / Q000235:genetics*
chemical_list: D054815:Cyclic Nucleotide-Gated Cation Channels; D004277:DNA, Single-Stranded; D005136:Eye Proteins; D007473:Ion Channels; D015106:3',5'-Cyclic-GMP Phosphodiesterases