title: Case report 720. Multicentric mixed tumor of bone with pulmonary involvement.
abstract: A man presented with a mass in the left first metacarpal bone. Later, his chest radiograph showed extensive, bilateral, rounded opacities in both lungs with enlarged hilar lymph nodes, and he developed expanding lesions in the left radius, ulna, and metacarpal bones. The pulmonary lesions were treated with radiotherapy and cytotoxic agents, and the tumor mass in the first metacarpal was debulked. All biopsies showed similar features of a mixed tumor (pleomorphic adenoma) with metastatic or embolic pulmonary involvement; ultrastructural and immunocytochemical investigations supported this unique diagnosis. The patient remains well 15 years after the initial diagnosis. It is possible that the myoepithelial elements in this case had been displaced intraosseously during development. We are not aware of a similar case in the literature.
authors.affiliation: Department of Anatomical Pathology, Groote Schuur Hospital, Cape Town, Republic of South Africa.
authors.forename: A G
authors.initials: AG
authors.lastname: Rose
authors.forename: N G
authors.initials: NG
authors.lastname: Heselson
authors.forename: R K
authors.initials: RK
authors.lastname: Marks
authors.forename: D
authors.initials: D
authors.lastname: Kranold
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary*; D008297:Male; D008663:Metacarpus; D009373:Neoplasms, Germ Cell and Embryonal / Q000000981:diagnostic imaging* / Q000473:pathology / Q000556:secondary; D011859:Radiography; D011884:Radius