title: Influence of the electrical stimulation of the medial amygdala on adrenocortical sensitivity to adrenocorticotrophin in hypophysectomized rats.
abstract: The effects of electrical stimulation of medial amygdala on the adrenocortical sensitivity to adrenocorticotrophin (ACTH) were investigated in hypophysectomized rats. The intravenous injection of ACTH increased the rates of 14C transfer from 14C-l-acetate into corticosterone and cortisol in the adrenal slices of hypophysectomized rats. The electrical stimulation of the medial amygdala produced a further increase in the rates of 14C transfer from 14C-l-acetate into corticosterone and cortisol. From these results, it might be suggested that the medial amygdala was capable of enhancing the adrenocortical steroidogenesis in response to ACTH.
authors.affiliation: Department of Physiology, Kochi Medical School, Nankoku, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Saito
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: H
authors.initials: H
authors.lastname: Kaba
authors.forename: F
authors.initials: F
authors.lastname: Okutani
authors.forename: G Z
authors.initials: GZ
authors.lastname: Yu
authors.forename: K
authors.initials: K
authors.lastname: Seto
authors.forename: F
authors.initials: F
authors.lastname: Kimura
authors.forename: M
authors.initials: M
authors.lastname: Kawakami
authors.forename: S
authors.initials: S
authors.lastname: Roberts
mesh_terms: D000085:Acetates / Q000378:metabolism; D000302:Adrenal Cortex / Q000187:drug effects* / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000679:Amygdala / Q000502:physiology*; D000818:Animals; D003345:Corticosterone / Q000378:metabolism; D004558:Electric Stimulation; D006854:Hydrocortisone / Q000378:metabolism; D007016:Hypophysectomy; D051381:Rats
chemical_list: D000085:Acetates; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone; D006854:Hydrocortisone