Developmental regulation of annexin II (Lipocortin 2) in human brain and expression in high grade glioma.
In experiments to identify molecules that might be important in the pathogenesis of glioblastoma multiforme, the most common malignant brain tumor, we found that annexin II (Lipocortin 2, p36), a likely second messenger in several different mitogenic pathways, was highly expressed in tumor tissue of glioblastoma multiforme (9 of 9) and highly anaplastic astrocytoma (2 of 6), but not in astrocytomas of lower pathological grade (0 of 6). We also detected high levels of annexin II expression in fetal brain during the period when radial glia proliferate, although annexin II expression was not detected in normal adult brain. These data demonstrate that annexin II expression is developmentally regulated in the human central nervous system and suggest that the early progenitor radial glia share important characteristics with highly malignant glial tumors.
Reeves
S A
SA
Department of Neurological Surgery, School of Medicine, University of California, San Francisco 94143.
Chavez-Kappel
C
C
Davis
R
R
Rosenblum
M
M
Israel
M A
MA
D000595:Amino Acid Sequence; D017306:Annexin A2 / Q000032:analysis* / Q000235:genetics; D001254:Astrocytoma / Q000378:metabolism*; D001483:Base Sequence; D001921:Brain / Q000378:metabolism*; D001932:Brain Neoplasms / Q000378:metabolism*; D066246:ErbB Receptors / Q000032:analysis / Q000235:genetics; D005333:Fetus / Q000378:metabolism; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis / Q000235:genetics; D005909:Glioblastoma / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000032:analysis
D017306:Annexin A2; D005904:Glial Fibrillary Acidic Protein; D012333:RNA, Messenger; D066246:ErbB Receptors