title: [Effect of hypoosmotic stimulation of the gastrointestinal mucosa on the activity of NA+, K+-atpase of epithelial cells in the small intestine and kidney in rats].
abstract: The experiments on Wistar rats have shown that intragestral injection with mannitol hypotonic solution (20 mmol/l) causes the significant activation of Na+, K(+)-ATPase of duodenum and distal intestine epithelial cells, kidney cortex cells, but does not affect the brain cortex of Na+, K(+)-ATPase activity. Simultaneously the activator of enzyme (AE) enters blood serum of rats, its activity is revealed by blood serum addition to homogenates of tissues of control rats. It is assumed that AE is produced in duodenal and intestinal mucosa released to blood after stimulation of mucosal surface by hypotonic solutions and included into the osmoregulation processes on the Na+, K(+)-ATPase level.
authors.forename: M S
authors.initials: MS
authors.lastname: Iaremenko
authors.forename: O M
authors.initials: OM
authors.lastname: Prokopenko
authors.forename: G L
authors.initials: GL
authors.lastname: Vavilova
authors.forename: O M
authors.initials: OM
authors.lastname: Kharlamova
mesh_terms: D000818:Animals; D004848:Epithelium; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects / Q000201:enzymology; D007038:Hypotonic Solutions; D007413:Intestinal Mucosa / Q000166:cytology / Q000187:drug effects / Q000201:enzymology; D007421:Intestine, Small / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D007672:Kidney Cortex / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D008353:Mannitol / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects* / Q000378:metabolism
chemical_list: D007038:Hypotonic Solutions; D008353:Mannitol; D000254:Sodium-Potassium-Exchanging ATPase
vernacular_title: Vplyv giposmotychnoĭ stymuliatsiĭ slyzovoĭ poverkhni shlunkovo- kyshkovogo traktu na aktyvnist Na+, K+- ATFazy v klitynakh epiteliiu tonkoĭ kyshky ta nyrok shchuriv.