Haematological and erythrocyte membrane changes induced by amiodarone, in rats.
The effect of Amiodarone (AD), a cationic amphiphilic drug, on erythrocytes and leucocytes was studied. Treatment of rats with AD showed a significant decrease in the red cell count and the level of Hemoglobin. Amiodarone altered the fluidity of the erythrocyte membrane followed by a decrease in the activities of membrane bound enzymes like (Na+, K+)-ATPase, Acetylcholine esterase and NADH dehydrogenase. A slight increase in the leucocyte count was also observed in the treated animals.
Padmavathy
B
B
Department of Biochemistry, University of Madras.
Devraj
N S
NS
Devraj
H
H
D000638:Amiodarone / Q000494:pharmacology*; D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D004906:Erythrocyte Count / Q000187:drug effects*; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000201:enzymology; D006454:Hemoglobins / Q000378:metabolism; D007958:Leukocyte Count / Q000187:drug effects*; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood / Q000378:metabolism
D006454:Hemoglobins; D010743:Phospholipids; D002784:Cholesterol; D000254:Sodium-Potassium-Exchanging ATPase; D000638:Amiodarone