title: Repression of the viral latent promoter BC-R2 in Epstein-Barr virus negative cell lines.
abstract: The regulation of the latent promoter BC-R2 of Epstein-Barr virus (EBV) was examined using the chloramphenicol acetyl transferase (CAT) gene reporter system. A 5' deletion analysis of BC-R2 promoter sequences has been used to characterize a region, described previously as a transcriptional enhancer in EBV positive cell lines, which can repress the BC-R2 transcriptional activity in EBV negative cell lines.
authors.affiliation: Laboratoire de Génétique des Virus Oncogènes, URA 1301 CNRS, Institut Gustave Roussy, Villejuif, France.
authors.forename: B
authors.initials: B
authors.lastname: Klonjkowski
authors.forename: D
authors.initials: D
authors.lastname: Walls
authors.forename: P
authors.initials: P
authors.lastname: Gilardi-Hebenstreit
authors.forename: M
authors.initials: M
authors.lastname: Perricaudet
mesh_terms: D002051:Burkitt Lymphoma; D002460:Cell Line; D015500:Chloramphenicol O-Acetyltransferase / Q000235:genetics / Q000378:metabolism*; D004261:DNA Replication; D004742:Enhancer Elements, Genetic; D005091:Exons; D017353:Gene Deletion; D015967:Gene Expression Regulation, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D010957:Plasmids; D011401:Promoter Regions, Genetic; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured
chemical_list: D011993:Recombinant Fusion Proteins; D015500:Chloramphenicol O-Acetyltransferase