Enhancement of working memory performance in the rat by MDL 26,479, a novel compound with activity at the GABAA receptor complex.
MDL 26,479, a novel triazole compound with action at the GABAA receptor complex, was examined in 2 models of working memory deficit in the rat. MDL 26,479 attenuated a scopolamine-induced acquisition deficit in a T-maze reinforced alternation task. MDL 26,479 also reversed a performance deficit induced by increased delay between sample and choice trials in the same task, suggesting that the compound may have memory enhancing potential. This finding further supports claims that drugs acting at the GABAA receptor complex are of potential use in the treatment of memory disorder.
Moran
P M
PM
Marion Merrell Dow Research Institute, Strasbourg, France.
Kane
J M
JM
Moser
P C
PC
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007858:Learning; D008297:Male; D008568:Memory / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology*; D012016:Reference Values; D012054:Reinforcement, Psychology; D012601:Scopolamine / Q000494:pharmacology; D014230:Triazoles / Q000494:pharmacology*
D000928:Antidepressive Agents; D011963:Receptors, GABA-A; D014230:Triazoles; C065324:suritozole; D012601:Scopolamine