[The effect of intravenous furosemide on the hemodynamic parameters and colloid osmotic pressure in patients with pulmonary edema].
OBJECTIVE
To evaluate the effects of intravenous furosemide over hemodynamics variables and colloid osmotic pressure in patients with pulmonary edema.


METHODS
Eight patients with pulmonary edema, mean age of 58.3 +/- 7.5 years, 6 men, were evaluated. Hemodynamic monitoring was performed by Swan-Ganz catheter in pulmonary artery to obtain RAP and PAWP, in mmHg, and HR, in bpm. Cardiac output (CO) was obtained by thermodilution method. Cardiac index (CI) in L/min/m2, and systolic index, in ml, arose from variables above. Mean arterial pressure (MAP), in mmHg, was obtained through catheterization of radial artery. patients were treated with 20 mg of intravenous furosemide, and hemodynamic variables were measured before and after 5, 15, 30, 60 and 120 minutes. COP was measured in Weil oncometer (IL 196) at same intervals.


RESULTS
A significant reduction of RAP (p = 0.002) and PAWP (p < 0.0001), HR (p = 0.02), COP (p < 0.0001) and gradient between PAWP-COP (p < 0.0001) were observed. RAP and PAWP reduction was greater in the first five minutes and, otherwise, COP reduction was gradual in 120 min. PAWP-COP gradient initially positive, stayed negative during all study. MAP, CI, SI and SVR did not show statistical differences.


CONCLUSIONS
Furosemide administration reduced RAP, PAWP, HR, COP and PAWP-COP gradient, probably by a redistribution of fluid excess in the interstitial to intravascular space, through changes in driving fluid forces, with predominance in colloid osmotic pressure, which reverse fluid from intravascular to interstitial observed in pulmonary edema.
Ramires
J A
JA
Mansur
A de P
Ade P
Lage
S G
SG
César
L A
LA
Tsanaclis
A
A
da Luz
P L
PL
Pileggi
F
F
D000208:Acute Disease; D000368:Aged; D004341:Drug Evaluation; D005260:Female; D005665:Furosemide / Q000008:administration & dosage* / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D009997:Osmotic Pressure / Q000187:drug effects; D011654:Pulmonary Edema / Q000188:drug therapy* / Q000503:physiopathology
D005665:Furosemide
Efeito da furosemida endovenosa sobre os parâmetros hemodinãmicos e na pressão coloidosmótica em pacientes com congestão pulmonar.