[Effect of small doses of L-dopa on synergic tonic reaction in patients with childhood cerebral palsy].
As many as 8 patients aged 8-19 years suffering from infantile cerebral paralysis (ICP) with torsion dystonia, akinetic, rigid, spastic and hypotonically atactic syndromes were examined for the maximum amplitude of EMG activity of the musculus tibialis anterior in voluntary rear flexion of the foot and in Strümpell's tibial synkinesia before treatment and after intake of small doses of L-DOPA (nakom, 62 mg/day). It has been established that the amplitude of voluntary EMG activity and the rate of impulse transmission in efferents of the tibial nerve remained practically unchanged during treatment; in all the cases, the synergic EMG activity, discharges of EMG and prolonged activity decreased; the scope of active movements in the talocrural joint increased by 10-20 degrees. The greatest decrease of synergic EMG activity (by 40%) was recorded in patients with rigid muscle tone, the mean in patients with spastic and spastic -dystonic (by 25-33%), the least one (17%) in muscle hypotonia. It is assumed that voluntary and synergic automatic movements have varying neuromediator supply. The effect of L-DOPA is realized via changes in the function of suprasegmental brain structures regulating polysynaptic postural reflexes with primary action on extensors. The effects of the subcortical nuclei, stem and cerebellar systems are made possible by dopamine neuromediation to a different measure.
Brin
I L
IL
Bakhteev
K K
KK
Naĭdel'
A V
AV
D000293:Adolescent; D000328:Adult; D002547:Cerebral Palsy / Q000188:drug therapy* / Q000503:physiopathology; D002648:Child; D004576:Electromyography; D006801:Humans; D007866:Leg; D007980:Levodopa / Q000008:administration & dosage*; D009068:Movement / Q000187:drug effects* / Q000502:physiology; D009119:Muscle Contraction / Q000187:drug effects* / Q000502:physiology; D009123:Muscle Hypotonia / Q000503:physiopathology; D009127:Muscle Rigidity / Q000503:physiopathology; D009132:Muscles / Q000187:drug effects* / Q000294:innervation / Q000503:physiopathology; D009431:Neural Conduction / Q000187:drug effects / Q000502:physiology; D013979:Tibial Nerve / Q000187:drug effects / Q000503:physiopathology
D007980:Levodopa
Vliianie malykh doz L-dopa na sinergicheskuiu tonicheskuiu reaktsiiu u bol'nykh detskim tserebral'nym paralichom.