title: Assessment of a new modified soft jelly capsule containing nonoxynol as spermicide contraceptive.
abstract: The mean rupture time, after its vaginal insertion, of a new modified soft jelly capsule containing nonoxynol-9 (DF-486) was investigated in 40 women. The subjects were randomly allocated to 8 study groups. The capsules remained in the vagina from 2-13 minutes. Vaginal infection, vaginal dryness, and multiparity, were recorded. Capsule rupture was not observed at minute 2; 20% of capsules that remained in the vagina 3 minutes suffered rupture, as did 80% of capsules that remained 4, 5 and 7 minutes, and 100% of those remaining 9 minutes or more. The mean rupture time of the studied capsules was 8.2 minutes with 95% confidence limits of 6.2 and 8.8 minutes. At minutes 2-7, vaginal infection, dryness and tone diminution probably accounted for lack of rupture; after minute 7, these factors did not influence capsule rupture.
authors.affiliation: Department of Reproductive Biology, University of Coahuila, School of Medicine, Torreon, Mexico.
authors.forename: R
authors.initials: R
authors.lastname: Recio
authors.forename: S
authors.initials: S
authors.lastname: Bassol
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D002214:Capsules; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D017137:Nonoxynol; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000009:adverse effects; D013089:Spermatocidal Agents / Q000008:administration & dosage* / Q000009:adverse effects; D013997:Time Factors
chemical_list: D002214:Capsules; D013089:Spermatocidal Agents; D017137:Nonoxynol; D011092:Polyethylene Glycols