title: Near-haploid clones in a malignant fibrous histiocytoma.
abstract: Near-haploid solid tumors are very rare. In a storiform-pleomorphic malignant fibrous histiocytoma (MFH) of bone, we found three cell populations: one with a near-haploid, a second with a near-diploid, and a third with a near-tetraploid chromosome number. The near-haploid cells had few structural rearrangements: i(12p) and t(13q21q) in one clone, and these two and an additional t(19;?)(p11;?) in another clone. One structurally normal copy of all chromosomes was also present, except that the only chromosome 13 was involved in the t(13q21q). There were also two near-diploid clones, one without the t(19;?) and one with a single copy of this derivative chromosome. This is the first tumor with i(12p) among bone and soft tissue tumors.
authors.affiliation: Department of Clinical Genetics, University Hospital, Lund, Sweden.
authors.forename: C
authors.initials: C
authors.lastname: Orndal
authors.forename: N
authors.initials: N
authors.lastname: Mandahl
authors.forename: B
authors.initials: B
authors.lastname: Carlén
authors.forename: H
authors.initials: H
authors.lastname: Willén
authors.forename: J
authors.initials: J
authors.lastname: Wennerberg
authors.forename: S
authors.initials: S
authors.lastname: Heim
authors.forename: F
authors.initials: F
authors.lastname: Mitelman
mesh_terms: D007446:Chromosome Inversion; D002881:Chromosomes, Human, Pair 12; D005260:Female; D006238:Haploidy; D018219:Histiocytoma, Benign Fibrous / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D008339:Mandibular Neoplasms / Q000235:genetics* / Q000473:pathology; D008854:Microscopy, Electron; D008875:Middle Aged; D014407:Tumor Cells, Cultured