The expression of the EBV latent membrane protein (LMP-1) is independent of CD23 and bcl-2 in Reed-Sternberg cells in Hodgkin's disease.
A series of 33 cases of Hodgkin's disease was investigated for the presence of the EBV encoded latent gene product LMP-1 and of CD23 using immunohistochemical techniques. The expression of bcl-2 was examined in a subset of cases. LMP-1 was detected in the Reed-Sternberg cells in 15 cases. Although LMP-1 is known to upregulate CD23 and bcl-2, there was no correlation between the expression of LMP-1 and the detection of CD23 and bcl-2 in Reed-Sternberg cells.
Armstrong
A A
AA
Department of Veterinary Pathology, University of Glasgow, UK.
Gallagher
A
A
Krajewski
A S
AS
Jones
D B
DB
Wilkins
B S
BS
Onions
D E
DE
Jarrett
R F
RF
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000032:analysis; D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis*; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006689:Hodgkin Disease / Q000276:immunology / Q000382:microbiology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000032:analysis; D019253:Proto-Oncogene Proteins c-bcl-2; D011961:Receptors, Fc / Q000032:analysis; D017455:Receptors, IgE; D016539:Reed-Sternberg Cells / Q000276:immunology* / Q000382:microbiology; D014412:Tumor Virus Infections / Q000276:immunology*; D014763:Viral Matrix Proteins
D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; D000951:Antigens, Neoplasm; D000956:Antigens, Viral; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D011961:Receptors, Fc; D017455:Receptors, IgE; D014763:Viral Matrix Proteins