Neurokinin concentrations in cerebrospinal fluid. A preliminary study in Parkinson's disease.
Immunoreactive neurokinin A was measured in the cerebrospinal fluid of twelve patients with Parkinson's disease and eleven normal subjects, using a sensitive and precise extraction/concentration radioimmunoassay method. The mean value obtained in Parkinson's disease patients (13.2 +/- 4.6 pmol/l) was lower than that of the controls (17.4 +/- 5.9). The tendency toward a significant decrease (p = 0.085) found in this preliminary study could indicate that neurokinin A containing neurons are involved in the pathophysiology of Parkinson's disease. In addition, the establishment of reference values for neurokinin A in cerebrospinal fluid may provide a basis for further studies of this neuropeptide in neurological disorders.
Galard
R
R
Department of Biochemistry, Valle Hebrón General Hospital, Barcelona, Spain.
Catalán
R
R
Montalbán
J
J
Molins
A
A
Miquel
F
F
Castellanos
J M
JM
D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015288:Neurokinin A / Q000134:cerebrospinal fluid*; D010300:Parkinson Disease / Q000134:cerebrospinal fluid*; D011863:Radioimmunoassay; D012016:Reference Values
D015288:Neurokinin A