title: Specificity of the anticollagenase action of tetracyclines: relevance to their anti-inflammatory potential.
abstract: The concentrations of doxycycline and 4-de-dimethylaminotetracycline required to inhibit 50% of collagenase activity were found to be 15 to 30 microM for human neutrophil and gingival crevicular fluid collagenases. Fibroblast collagenase was relatively resistant to inhibition by tetracyclines; the 50% inhibitory concentrations of doxycycline and 4-de-dimethylaminotetracycline were 280 and 510 microM, respectively.
authors.affiliation: Department of Periodontology, University of Helsinki, Finland.
authors.forename: K
authors.initials: K
authors.lastname: Suomalainen
authors.forename: T
authors.initials: T
authors.lastname: Sorsa
authors.forename: L M
authors.initials: LM
authors.lastname: Golub
authors.forename: N
authors.initials: N
authors.lastname: Ramamurthy
authors.forename: H M
authors.initials: HM
authors.lastname: Lee
authors.forename: V J
authors.initials: VJ
authors.lastname: Uitto
authors.forename: H
authors.initials: H
authors.lastname: Saari
authors.forename: Y T
authors.initials: YT
authors.lastname: Konttinen
mesh_terms: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects / Q000201:enzymology; D006801:Humans; D003012:Microbial Collagenase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology; D013754:Tetracyclines / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D013754:Tetracyclines; D003012:Microbial Collagenase