title: GABA receptor alterations after chronic lithium administration. Comparison with carbamazepine and sodium valproate.
abstract: 1. Effects of lithium, carbamazepine, sodium valproate and baclofen on GABA receptors were examined in several regions of the rat brain. 2. [3H]Muscimol (MUS) and [3H] (-)baclofen (BAC) were used to label GABAA and GABAB receptors, respectively, in synaptic membranes from rat brain. 3. Single treatment with lithium chloride, carbamazepine or sodium valproate did not change [3H]MUS or [3H]BAC binding in the frontal cortex, hippocampus and thalamus. 4. Following chronic treatment with lithium, carbamazepine or sodium valproate, [3H]BAC binding was significantly increased in the hippocampus but not in the frontal cortex, thalamus or striatum. 5. [3H]Muscimol binding did not change in any region examined after chronic treatment with lithium, carbamazepine or sodium valproate. 6. Single and chronic administration of baclofen did not change [3H]MUS or [3H]BAC binding. 7. One common mechanism of action of mood stabilizers may be mediated by GABAB receptors in the hippocampus.
authors.affiliation: Department of Neuropsychiatry, Yamanashi Medical College, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Motohashi
mesh_terms: D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002220:Carbamazepine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D009118:Muscimol / Q000494:pharmacology; D051381:Rats; D011921:Rats, Inbred WKY; D011963:Receptors, GABA-A / Q000187:drug effects*; D014635:Valproic Acid / Q000494:pharmacology*
chemical_list: D011963:Receptors, GABA-A; D009118:Muscimol; D002220:Carbamazepine; D014635:Valproic Acid; D008094:Lithium; D001418:Baclofen