Supersensitivity to morphine of the transmurally stimulated vas deferens isolated from ethanol-pretreated mice.
The effect of chronic ethanol pretreatment on the sensitivity of the transmurally stimulated mouse vas deferens to morphine was studied. Vasa deferentia isolated from ethanol-pretreated mice showed supersensitivity to the twitch inhibitory effect of morphine. The affinity of the vas deferens mu-opioid receptors for naloxone was increased. It is concluded that ethanol pretreatment induces mu-opioid receptor alterations which are, at least partially, responsible for the observed supersensitivity to morphine.
Tabach
R
R
Department of Pharmacology, University of Sã Paulo, Brazil.
De Moraes
S
S
D000818:Animals; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology; D017450:Receptors, Opioid, mu / Q000502:physiology; D014649:Vas Deferens / Q000187:drug effects
D017450:Receptors, Opioid, mu; D009270:Naloxone; D000431:Ethanol; D009020:Morphine