A serotype 10 human rotavirus.
Rotaviruses with genome rearrangements isolated from a chronically infected immunodeficient child (F. Hundley, M. McIntyre, B. Clark, G. Beards, D. Wood, I. Chrystie, and U. Desselberger, J. Virol 61:3365-3372, 1987) are the first recognized human isolates of serotype 10. This was shown by both a direct enzyme-linked immunosorbent assay and virus neutralization assays using serotype specific monoclonal antibodies. The serotype was confirmed by sequence analysis of the gene encoding VP7, which revealed a 96% amino acid homology to the bovine serotype 10 isolate B223.
Beards
G
G
Regional Virus Laboratory, East Birmingham Hospital, United Kingdom.
Xu
L
L
Ballard
A
A
Desselberger
U
U
McCrae
M A
MA
D000595:Amino Acid Sequence; D000911:Antibodies, Monoclonal; D001483:Base Sequence; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008969:Molecular Sequence Data; D009500:Neutralization Tests; D012401:Rotavirus / Q000145:classification / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D012703:Serotyping / Q000379:methods
D000911:Antibodies, Monoclonal