[Approach to studying natural oligopeptides in the area of structure relationship to function].
Structure and structure-function relations of naturally occurring oligopeptides and peptide receptors are discussed. An approach to inferring function of low-molecular peptides in the direction from their structure is postulated. Diverse biological activities of oligopeptides supposedly arise from a limited number of preferable spatial structures which may exist under physiological conditions. Each particular function of an oligopeptide is connected with a definite spatial structure, belonging to the set of the low-energy conformations. A method is suggested for constructing a synthetic analogue with a predetermined physiologically active conformation, prior to all chemical and biological tests.
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D009842:Oligopeptides / Q000737:chemistry* / Q000378:metabolism; D011487:Protein Conformation; D011956:Receptors, Cell Surface / Q000378:metabolism; D013329:Structure-Activity Relationship
D009842:Oligopeptides; D011956:Receptors, Cell Surface
Podkhod k issledovaniiu prirodnykh oligopeptidov v napravlenii ot struktury k funktsii.