ORG 2766 fails to improve visual functions in rats with occipital lesions.
Adult rats were trained on a white versus black card discrimination in a circular water tank. Three independent variables were manipulated: lesion (sham, lateral occipital, medial occipital), dose of ORG 2766 administered (0 or 25 micrograms in saline on alternate days for 18 days), and time of administration (during the post-surgical recovery interval or during post-operative testing). Both visual cortical lesions produced a prominent retention deficit and defective pattern vision. Neither post-surgical nor concurrent administration of ORG 2766 improved visual functions. These results, along with a growing body of evidence, challenge the generality of the positive influences of ORG 2766 upon behavioral recovery observed in animals with limbic lesions.
Schmidt
M S
MS
Department of Psychology, Georgia College, Milledgeville 31061.
Chirino-Barcelo
F I
FI
McDaniel
W F
WF
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D004192:Discrimination, Psychological / Q000187:drug effects; D005260:Female; D008297:Male; D009778:Occipital Lobe / Q000033:anatomy & histology / Q000502:physiology*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D012727:Sex Characteristics; D014785:Vision, Ocular / Q000187:drug effects*
D010446:Peptide Fragments; C013765:Org 2766; D000324:Adrenocorticotropic Hormone