Effect of oxymetazoline nose drops on vascular permeability of the nasal mucosa in the rabbit after provocation with leukotriene B4.
The effects of oxymetazoline nose drops on the vascular permeability of the nasal mucosa in a provoked inflammatory reaction was studied in anesthetized rabbits. Vascular permeability (125I-albumin) was 53% higher in the leukotriene B4-provoked nostril (LTB4) compared with the vehicle-treated contralateral nostril (p < 0.05). The amount of secretions was, however, not different from the vehicle-treated side. The LTB4-induced increase in permeability was decreased by 22% when oxymetazoline was introduced (p < 0.05), and the amount of secretions was reduced by 22% (p < 0.01). The effect of oxymetazoline on the vascular permeability of the nasal mucosa can be attributed to a vascular constriction (decrease in blood flow) and/or a change in the permeability characteristics. The LTB4-induced increase in vascular permeability was not attenuated by the monoclonal antibody IB4 directed against the neutrophil adhesion complex CD11/CD18. The latter suggests that LTB4-induced vascular permeability does not require CD18-mediated neutrophil adherence in the nasal mucosa.
Bende
M
M
Department of Applied Mechanics and Engineering Sciences-Bioengineering, San Diego, La Jolla, Calif.
Hansell
P
P
Intaglietta
M
M
Arfors
K E
KE
D000281:Administration, Intranasal; D000818:Animals; D000911:Antibodies, Monoclonal / Q000145:classification / Q000276:immunology; D002199:Capillary Permeability / Q000187:drug effects*; D007975:Leukotriene B4 / Q000008:administration & dosage / Q000276:immunology*; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects*; D009299:Nasal Provocation Tests; D010109:Oxymetazoline / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits; D012220:Rhinitis / Q000188:drug therapy / Q000209:etiology / Q000276:immunology*
D000911:Antibodies, Monoclonal; D007975:Leukotriene B4; D010109:Oxymetazoline