title: [Prophylaxis of cytomegalovirus infections with ganciclovir in kidney transplant recipients].
abstract: In an open-labeled randomized study, prophylactic treatment with ganciclovir (day 15 to day 29) was administered to 23 cytomegalovirus seronegative patients who received a kidney from a cytomegalovirus seropositive donor. Both groups (control = 11, ganciclovir = 12) were similar in age, immunosuppressive treatments, acute rejection episodes and number of steroid pulses. A seroconversion occurred in 10 control patients (91 percent) and in 10 patients of the ganciclovir group (84 percent). A cytomegalovirus disease was observed in 10 control patients (91 percent) and in 8 patients of the ganciclovir group (66 percent). The delay between grafting and cytomegalovirus disease was significantly longer in the ganciclovir than in the control group (78.5 +/- 7.7 vs 46.5 +/- 5.5 days, P < 0.05). In conclusion, in renal transplant recipients who are at high risk of cytomegalovirus disease, prophylactic treatment with ganciclovir delays the onset of the disease and seems to decrease slightly its frequency.
authors.affiliation: Service de Néphrologie, Hôpital Tenon, Paris.
authors.forename: E
authors.initials: E
authors.lastname: Rondeau
authors.forename: B
authors.initials: B
authors.lastname: Bourgeon
authors.forename: M N
authors.initials: MN
authors.lastname: Peraldi
authors.forename: P
authors.initials: P
authors.lastname: Lang
authors.forename: C
authors.initials: C
authors.lastname: Buisson
authors.forename: K M
authors.initials: KM
authors.lastname: Schulte
authors.forename: B
authors.initials: B
authors.lastname: Weill
authors.forename: J D
authors.initials: JD
authors.lastname: Sraer
mesh_terms: D003586:Cytomegalovirus Infections / Q000209:etiology / Q000517:prevention & control*; D015774:Ganciclovir / Q000627:therapeutic use*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*
chemical_list: D015774:Ganciclovir
vernacular_title: Prophylaxie des infections à cytomégalovirus par le ganciclovir chez les receveurs de greffe de rein.