The participation of ribosomes in protein glycosylation. Interaction of the ribosome-UDP-N-acetyl-glucosamine complex with dolichol phosphate.
UDP-N-acetylglucosamine can be bound by pure ribosomes. The part of N-acetylglucosamine-1-P can be transferred from the complex ribosome-UDP-N-acetylglucosamine onto dolichol phosphate. Evidence is presented that N-acetylglucosamine bound to dolichol phosphate can be transferred to the nascent peptide synthesized on the ribosome.
Paszkiewicz-Gadek
A
A
Department of General and Organic Chemistry, Institute of Chemistry, Medical Academy, Białystok, Poland.
Porowska
H
H
Gałasiński
W
W
D000117:Acetylglucosamine / Q000378:metabolism; D000818:Animals; D002250:Carbon Radioisotopes; D002845:Chromatography; D004288:Dolichol Phosphates / Q000378:metabolism*; D006023:Glycoproteins / Q000096:biosynthesis* / Q000378:metabolism; D006031:Glycosylation; D008297:Male; D010770:Phosphotransferases / Q000378:metabolism; D014176:Protein Biosynthesis; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012270:Ribosomes / Q000378:metabolism* / Q000502:physiology; D017855:Transferases (Other Substituted Phosphate Groups); D014537:Uridine Diphosphate N-Acetylglucosamine / Q000378:metabolism*
D002250:Carbon Radioisotopes; D004288:Dolichol Phosphates; D006023:Glycoproteins; D011506:Proteins; D014537:Uridine Diphosphate N-Acetylglucosamine; D010770:Phosphotransferases; D017855:Transferases (Other Substituted Phosphate Groups); C023222:UDPacetylglucosamine-dolichyl-phosphate acetylglucosamine-1-phosphate transferase; D000117:Acetylglucosamine