[Iron absorption in HbH disease].
We have reported that many cases of Hb H disease have a complication of iron overload without a history of multiple blood transfusion or prolonged iron therapy. We determined their iron absorption by 59Fe whole body counting in 13 such cases. Also 10 normal subjects were studied as a control group. The results showed a significant increase in iron absorption to 20.3%, in contrast to 6.9% in the normal control. This was further documented by their RBC incorporation (i.e. the percentage of orally administered) 59Fe recovered in the total RBC mass) on day 14 (13.7% vs 6.1%). The degree of ineffective erythropoiesis might not be severe considering their similar 59Fe utilization by RBC (i.e. the percentage of absorbed 59Fe recovered in the RBC) to the normals (86.3% vs. 84.3%).
Lin
C K
CK
Department of Medicine, Veterans General Hospital, Taipei.
Lin
J S
JS
Chen
S Y
SY
Lo
J G
JG
Chien
C C
CC
Liu
R S
RS
Jiang
M C
MC
Lee
S H
SH
D000042:Absorption; D005260:Female; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008297:Male; D013789:Thalassemia / Q000378:metabolism*
D007501:Iron