On the role of bradykinin in secretion from vascular endothelial cells.
Bradykinin will induce, in perfused rat hindlegs, the acute release from endothelial cells of tissue-type plasminogen activator and of von Willebrand factor. This release is mediated by B2-receptors, requires the influx of extracellular calcium, and is modulated by cyclic nucleotides. A possible role of bradykinin in the physiological regulation of plasma levels of tissue-type plasminogen activator is discussed.
Emeis
J J
JJ
Gaubius Laboratory IVVO-TNO, Leiden, The Netherlands.
Tranquille
N
N
D015124:8-Bromo Cyclic Adenosine Monophosphate / Q000494:pharmacology; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology; D001920:Bradykinin / Q000494:pharmacology*; D002118:Calcium / Q000502:physiology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000502:physiology*; D006152:Cyclic GMP / Q000031:analogs & derivatives / Q000494:pharmacology / Q000502:physiology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D006614:Hindlimb / Q000098:blood supply; D007700:Kinetics; D008297:Male; D009599:Nitroprusside / Q000494:pharmacology; D010477:Perfusion; D051381:Rats; D017208:Rats, Wistar; D018002:Receptors, Bradykinin; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology; D010959:Tissue Plasminogen Activator / Q000378:metabolism*; D014841:von Willebrand Factor / Q000378:metabolism*
D002121:Calcium Channel Blockers; D018002:Receptors, Bradykinin; D017981:Receptors, Neurotransmitter; D014841:von Willebrand Factor; D009599:Nitroprusside; D005576:Colforsin; D015124:8-Bromo Cyclic Adenosine Monophosphate; C016276:8-bromocyclic GMP; D009320:Atrial Natriuretic Factor; D000242:Cyclic AMP; D010959:Tissue Plasminogen Activator; D006152:Cyclic GMP; D001920:Bradykinin; D002118:Calcium