Diverse classes of T-cell lymphomas arise in T-lymphocyte-inductive epitheliomas of the mouse salivary gland.
During the course of serial transplantations of polyomavirus-induced C3H-Bittner salivary gland epitheliomas in F1-hybrid mice, three tumor sublines were found which gave rise to T-cell lymphomas of host origin. The lymphomas resembled spontaneous AKR/J thymic lymphomas in their expression of lymphoid differentiation antigens, and they may represent sequential stages in the differentiation of immature T lymphocytes. We found no evidence that polyomavirus directly induced the lymphomas, rather, the lymphomagenic events paralleled those which occur in spontaneous AKR/J thymic lymphomas.
Harrod
F A
FA
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235-9048.
Kettman
J R
JR
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D015139:Blotting, Southern; D004247:DNA / Q000032:analysis; D004273:DNA, Neoplasm / Q000032:analysis; D016679:Genome, Viral; D008213:Lymphocyte Activation / Q000502:physiology*; D016399:Lymphoma, T-Cell / Q000737:chemistry / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D010641:Phenotype; D011120:Polyomavirus / Q000235:genetics; D012468:Salivary Gland Neoplasms / Q000737:chemistry / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D013601:T-Lymphocytes / Q000737:chemistry / Q000276:immunology / Q000502:physiology*; D013950:Thymus Gland / Q000276:immunology; D013953:Thymus Neoplasms / Q000276:immunology / Q000382:microbiology / Q000473:pathology
D015415:Biomarkers; D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; D004247:DNA