Virus infections complicating bone marrow transplantation.
Virus infections account for considerable morbidity in bone marrow transplant (BMT) recipients. In all ages, members of the herpes virus group are the predominant pathogens. Of these, cytomegalovirus is pre-eminent in being the most frequent cause of death due to infection associated with the transplant procedure. Considerable effort is being invested in the development of preventative and therapeutic strategies to control this virus. Other potentially life-threatening virus infections may be acquired on the transplant unit as a result of cross-infection and can be caused by enteroviruses, rotaviruses and adenoviruses. Prevention of these infections is best achieved by implementation of strict infection-control measures.
Rogers
T R
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Department of Medical Microbiology, Charing Cross and Westminster Medical School, London.
D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D003586:Cytomegalovirus Infections / Q000209:etiology / Q000517:prevention & control; D015774:Ganciclovir / Q000627:therapeutic use; D006086:Graft vs Host Disease; D006561:Herpes Simplex / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D009503:Neutropenia / Q000150:complications; D012136:Respiratory Syncytial Viruses; D012141:Respiratory Tract Infections / Q000209:etiology / Q000517:prevention & control; D010253:Respirovirus Infections / Q000209:etiology / Q000517:prevention & control; D014019:Tissue Donors; D014777:Virus Diseases / Q000209:etiology* / Q000517:prevention & control
D015774:Ganciclovir; D000212:Acyclovir