title: Confirmation of the localization of the human GABAA receptor alpha 1-subunit gene (GABRA1) to distal 5q by linkage analysis.
abstract: The GABAA receptor is the major inhibitory neurotransmitter receptor in the mammalian brain. To date, 14 genes that encode subunits of this receptor have been identified; these appear to be scattered throughout the human genome and are under investigation as candidate loci for a number of neurological and psychiatric disorders. We report here a highly polymorphic (dC-dA)n repeat within the human alpha 1-subunit gene (GABRA1). Typing of this marker in the Centre d'Etude du Polymorphisme Humain (CEPH) panel of families confirms the previous assignment of the GABRA1 locus to the distal portion of chromosome 5q by demonstrating linkage to the markers CRI-L45 (D5S61) (Zmax = 11.00, theta max = 0.15), CRI-V1022 (D5S54) (Zmax = 7.25, theta max = 0.20), and CRI-P148 (D5S72) (Zmax = 5.71, theta max = 0.24).
authors.affiliation: Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, Imperial College, London, United Kingdom.
authors.forename: K J
authors.initials: KJ
authors.lastname: Johnson
authors.forename: T
authors.initials: T
authors.lastname: Sander
authors.forename: A A
authors.initials: AA
authors.lastname: Hicks
authors.forename: A
authors.initials: A
authors.lastname: van Marle
authors.forename: D
authors.initials: D
authors.lastname: Janz
authors.forename: M J
authors.initials: MJ
authors.lastname: Mullan
authors.forename: B P
authors.initials: BP
authors.lastname: Riley
authors.forename: M G
authors.initials: MG
authors.lastname: Darlison
mesh_terms: D001483:Base Sequence; D002460:Cell Line; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5; D004277:DNA, Single-Stranded; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010375:Pedigree; D011110:Polymorphism, Genetic; D011963:Receptors, GABA-A / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D004277:DNA, Single-Stranded; D011963:Receptors, GABA-A