[Cytomegalovirus retinitis in AIDS. Effectiveness and complications of long-term therapy].
In a retrospective study of the records of 64 patients with AIDS and cytomegalovirus (CMV) retinitis, 47 patients were evaluated regarding the effectiveness of initial virustatic therapy, and 41 patients regarding the anatomical and functional long-term development (maintenance therapy, rate and intervals of recurrences, complications, adverse drug reactions, time of survival, and visual outcome). The average survival time of 45 treated patients was 226 days (31-717 days). More than 90% responded to initial therapy with ganciclovir or foscarnet. Forty-four percent remained free of recurrences until they died (for up to 15 months); 56% had 1 to 4 recurrences, altogether 35 episodes, of which 14 occurred after withdrawal of therapy. Recurrences were treated with high-dose reinduction therapy with good or partial response in more than 80% of cases. Nine patients showed "smouldering retinitis" at a late stage. Two out of 45 patients became blind shortly after diagnosis despite therapy; both showed a course mimicking acute retinal necrosis syndrome with histologically proven CMV disease. None of the 43 patients on maintenance therapy for up to 2 years became blind in both eyes. Only 2 out of 43 patients had a poor visual outcome < 40/100 in the better eye at a late disease stage. Of 60 affected eyes, 11 showed retinal detachment, 14 eyes developed optic atrophy and 12 eyes became blind. Our retrospective study shows that consistent maintenance therapy of patients with CMV retinitis prevents severe deterioration of visual acuity in most cases even in long disease courses and thus maintains quality of life.
Schmitz
K
K
Augenabteilung, Städtisches Krankenhaus, München-Harlaching.
Fabricius
E M
EM
Popescu
M
M
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D003586:Cytomegalovirus Infections / Q000188:drug therapy*; D017245:Foscarnet / Q000008:administration & dosage*; D015774:Ganciclovir / Q000008:administration & dosage*; D006801:Humans; D008134:Long-Term Care; D012008:Recurrence; D012173:Retinitis / Q000188:drug therapy*; D012189:Retrospective Studies; D014792:Visual Acuity / Q000187:drug effects; D014794:Visual Fields / Q000187:drug effects
D017245:Foscarnet; D015774:Ganciclovir
Zytomegalievirusretinitis bei AIDS. Effizienz und Komplikationen der Langzeittherapie.