title: Induction of NGF by isoproterenol, 4-methylcatechol and serum occurs by three distinct mechanisms.
abstract: Evidence is provided that isoproterenol, 4-methylcatechol and serum induce NGF by three separate mechanisms. Isoproterenol and 4-methylcatechol induced NGF and NGF mRNA in mouse fibroblast L929 cells in either the presence or absence of serum. Propranolol prevented NGF induction by isoproterenol, but not by 4-methylcatechol or serum. All possible combinations of these inducers resulted in additive increases in the levels of NGF and NGF mRNA.
authors.affiliation: Cephalon, Inc., West Chester, PA 19380.
authors.forename: S
authors.initials: S
authors.lastname: Carswell
authors.forename: E K
authors.initials: EK
authors.lastname: Hoffman
authors.forename: K
authors.initials: K
authors.lastname: Clopton-Hartpence
authors.forename: H M
authors.initials: HM
authors.lastname: Wilcox
authors.forename: M E
authors.initials: ME
authors.lastname: Lewis
mesh_terms: D000818:Animals; D002396:Catechols / Q000494:pharmacology*; D002478:Cells, Cultured; D006736:Horses / Q000276:immunology; D007106:Immune Sera / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology*; D007739:L Cells / Q000378:metabolism; D051379:Mice; D009414:Nerve Growth Factors / Q000096:biosynthesis*; D011433:Propranolol / Q000494:pharmacology; D012333:RNA, Messenger / Q000096:biosynthesis
chemical_list: D002396:Catechols; D007106:Immune Sera; D009414:Nerve Growth Factors; D012333:RNA, Messenger; C018599:4-methylcatechol; D011433:Propranolol; D007545:Isoproterenol