[Liver transplantation associated with combined adjuvant treatment in hepatocellular carcinoma. Feasibility and preliminary results].
Combined adjuvant therapy was prospectively assessed in 7 patients receiving orthotopic liver transplantation for hepatocellular carcinoma complicating cirrhosis. The protocol included hepatic arterial chemotherapy while waiting for transplant, immediate preoperative liver irradiation, and early postoperative chemotherapy. There were no postoperative deaths, and morbidity included mainly hematologic toxicity of chemotherapy. Two patients died of tumor recurrence 6 and 14 months after transplant. The remaining 5 patients are alive and free of disease with a follow-up of 7 to 26 months. These results show the feasibility of aggressive adjuvant therapy in patients transplanted for hepatocellular carcinoma and suggest a possible effect of such a protocol on the prevention of tumor recurrence.
Cherqui
D
D
Hôpital Henri-Mondor, Créteil.
Piedbois
P
P
Duvoux
C
C
Mathieu
D
D
Le Péchoux
C
C
Lauzet
J Y
JY
Métreau
J M
JM
Rotman
N
N
Charlotte
F
F
Julien
M
M
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D004317:Doxorubicin / Q000627:therapeutic use; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D006801:Humans; D007459:Iodized Oil / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008942:Mitoxantrone / Q000627:therapeutic use; D011182:Postoperative Care; D011300:Preoperative Care; D011446:Prospective Studies
D007459:Iodized Oil; D004317:Doxorubicin; D008942:Mitoxantrone
Transplantation hépatique associée à un traitement adjuvant combiné dans le carcinome hépatocellulaire. Faisabilité et résultats préliminaires.