The effects of thymomodulin and thymolymphotropin on the stress response of neuroendocrine system by gamma-irradiated Wistar rat.
Thymomodulin and Thymolymphotropin, biologically active thymus derivative peptides exert recovery effects on the functionality of some membrane bound, mitochondrial and lysosomal enzymes (monoamine oxidase, ATPase, phosphatases, cytochrome oxidase, succinate oxidase) affected by gamma-irradiation. These drugs exert antistress effect by re-establishing the function of hypothalamus-pituitary-adrenal axis and that of lymphoid organs.
Abraham
A D
AD
Biological Research Institute, Cluj-Napoca, Romania.
Borşa
M
M
Sandu
V D
VD
Puica
C
C
Cicoş
V
V
Uray
Z
Z
D000818:Animals; D001921:Brain / Q000201:enzymology / Q000473:pathology / Q000528:radiation effects; D002462:Cell Membrane / Q000201:enzymology; D005720:Gamma Rays; D008221:Lymphoid Tissue / Q000201:enzymology / Q000473:pathology / Q000528:radiation effects; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D008928:Mitochondria / Q000201:enzymology; D008995:Monoamine Oxidase / Q000378:metabolism; D009490:Neurosecretory Systems / Q000201:enzymology / Q000473:pathology / Q000528:radiation effects*; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000473:pathology / Q000503:physiopathology*; D013949:Thymus Extracts / Q000494:pharmacology*
D013949:Thymus Extracts; C085191:thymolymphotropin; C051006:thymomodulin; D008995:Monoamine Oxidase