title: [Value of multiple cortical perforations for the rehabilitation of massive deep-frozen bone allografts. Experimental study in sheep].
abstract: Incorporation of massive cortical bone allografts in human is slow and remains incomplete. Late biopsies of implanted allografts or histological studies of explanted allografts always show the partial substitution of necrotic bone by new bone from the host. The aim of the present study was to evaluate the effect of drilling the massive deep-frozen cortical allografts in order to induce osteogenesis. Thirteen sheep were operated on and a standard segment of the proximal ulna was removed and the gap filled either by an unperforated allograft or by a perforated one. Based on histological and microradiographic examination, a quite complete substitution of the perforated allografts was observed but in this model no statistically significant difference was observed between perforated and unperforated allografts. Further study is needed to assess the effect of the perforations.
authors.affiliation: Départment d'orthopédie et de traumatologie, hôpital de Hautepierre, Strasbourg.
authors.forename: P
authors.initials: P
authors.lastname: Simon
authors.forename: S R
authors.initials: SR
authors.lastname: Babin
authors.forename: C
authors.initials: C
authors.lastname: Delloye
authors.forename: D
authors.initials: D
authors.lastname: Schmitt
mesh_terms: D000818:Animals; D016025:Bone Transplantation; D015925:Cryopreservation; D005069:Evaluation Studies as Topic; D012756:Sheep; D014184:Transplantation, Homologous
vernacular_title: Intérêt des multiperforations corticales dans la réhabitation des allogreffes osseuses massives cryoconservées. Etude expérimentale chez le mouton.