title: [Anti-polynuclear neutrophil cytoplasmic antibodies of the perinuclear type or p-ANCA].
abstract: Some neutrophil cytoplasmic auto-antibodies produce perinuclear immuno staining of alcohol-fixed neutrophils called P-Anca pattern. These autoantibodies show chiefly reactivity with myeloperoxidase in Elisa but other specificities have been detected (elastase, cathepsin, lactoferrin). These P-Anca anti-MPO are more frequent with renal angiitis but P-Anca (anti-MPO negative) are associated with other diseases without renal failure (rheumatoid arthritis, Gougerot-Sjogren and ulceritis colitis).
authors.affiliation: Laboratoire d'Immunologie, CHU Purpan, Toulouse.
authors.forename: F
authors.initials: F
authors.lastname: Oksman
authors.forename: C
authors.initials: C
authors.lastname: Soler
authors.forename: C
authors.initials: C
authors.lastname: Goudable
authors.forename: J
authors.initials: J
authors.lastname: Pourrat
authors.forename: J M
authors.initials: JM
authors.lastname: Suc
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000032:analysis / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G; D007674:Kidney Diseases / Q000276:immunology*; D009195:Peroxidase / Q000276:immunology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D001324:Autoantigens; D007074:Immunoglobulin G; D009195:Peroxidase
vernacular_title: Les anticorps anti-cytoplasme des polynucléaires neutrophiles de type périnucléaire ou P-Anca.