title: Detection of herpes simplex virus type-2 DNA and human papilloma virus DNA sequences in cervical carcinoma tissue by molecular hybridization.
abstract: Biopsy samples from one hundred and two patients with squamous cell carcinoma of the uterine cervix and tissues from twelve healthy normal cervical tissues (post hysterectomy) were examined for HSV-type 2 and HPV-11 DNA sequences by molecular hybridization technique. In the carcinoma tissue extracts 53% contained HSV-2 DNA, 27% -HSV-1-DNA and 36% showed HPV-11 gene sequences while 5.7% were found to contain both HPV and HSV-2 DNA. Biopsies from healthy cervix were completely negative for HSV-2 and HPV-11 DNA sequences.
authors.affiliation: Regional Cancer Centre, Medical College Campus, Trivandrum, India.
authors.forename: V
authors.initials: V
authors.lastname: Thankamani
authors.forename: T V
authors.initials: TV
authors.lastname: Kumari
authors.forename: D M
authors.initials: DM
authors.lastname: Vasudevan
mesh_terms: D001483:Base Sequence; D001706:Biopsy; D002584:Cervix Uteri / Q000737:chemistry / Q000473:pathology; D004279:DNA, Viral / Q000032:analysis* / Q000235:genetics; D005260:Female; D006801:Humans; D009693:Nucleic Acid Hybridization; D027383:Papillomaviridae / Q000235:genetics*; D018139:Simplexvirus / Q000235:genetics*; D002583:Uterine Cervical Neoplasms / Q000737:chemistry / Q000235:genetics* / Q000473:pathology
chemical_list: D004279:DNA, Viral