title: The quantitative difference in adrenergic alpha-1, alpha-2 and beta receptors between the prostatic and epididymal ends of dog vas deferens.
abstract: In order to study the regional differences in the distribution of adrenergic receptors of the vas deferens, we measured the amounts of adrenergic alpha-1, alpha-2 and beta receptors in prostatic, intermediate, and epididymal portions of the dog vas deferens using radioligand binding techniques. Saturation experiments with 3H-prazosin, 3H-yohimbine, and 3H-dihydroxy-alprenolol demonstrated that there were significant amounts of adrenergic alpha-1, alpha-2, and beta receptors, respectively, in these three portions. alpha-1 receptors existed most densely in the whole vas deferens. The prostatic portion was found to have the largest amounts of alpha-1 and alpha-2 receptors among three portions studied. beta-Receptors were distributed most densely in the intermediate portion. alpha-1, alpha-2, and beta adrenergic receptors show different distribution patterns throughout the whole length of vas deferens.
authors.affiliation: Second Department of Biochemistry, Akita University School of Medicine.
authors.forename: S
authors.initials: S
authors.lastname: Kondo
authors.forename: M
authors.initials: M
authors.lastname: Kagaya
authors.forename: Y
authors.initials: Y
authors.lastname: Tashima
authors.forename: T
authors.initials: T
authors.lastname: Morita
mesh_terms: D000818:Animals; D004285:Dogs; D004822:Epididymis; D008297:Male; D011467:Prostate; D011869:Radioligand Assay; D011942:Receptors, Adrenergic, alpha / Q000145:classification / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D014018:Tissue Distribution; D014649:Vas Deferens / Q000033:anatomy & histology / Q000378:metabolism*
chemical_list: D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta