Treponema denticola and Porphyromonas gingivalis as prognostic markers following periodontal treatment.
Subgingival plaque samples were collected from individuals with advanced periodontitis before and 3 to 11 weeks after scaling and root planing periodontal treatment. The plaque levels of Treponema denticola and Porphyromonas gingivalis antigens were measured before and after treatment by a quantitative immunoassay procedure using monoclonal antibodies specific for these oral bacteria. A decrease in mean levels of T. denticola (P less than .05) and P. gingivalis antigens (P less than .09) were observed following periodontal therapy. Improved health, as measured by a decrease in probing depth, was associated with a decrease in T. denticola antigen (P less than .05). These results suggest that the T. denticola levels of successfully treated sites decreased, while non-responding sites had levels of this microbial marker which were equal to or greater than the pre-treatment levels. These results provide additional evidence that T. denticola is associated with human adult severe periodontal disease, and can serve as a prognostic marker for disease recurrence.
Simonson
L G
LG
Naval Dental Research Institute, Great Lakes, IL.
Robinson
P J
PJ
Pranger
R J
RJ
Cohen
M E
ME
Morton
H E
HE
D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000382:microbiology / Q000628:therapy; D015415:Biomarkers; D015169:Colony Count, Microbial; D003773:Dental Plaque / Q000382:microbiology / Q000517:prevention & control; D012534:Dental Scaling; D005260:Female; D005884:Gingival Hemorrhage / Q000382:microbiology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010514:Periodontal Pocket / Q000382:microbiology / Q000628:therapy; D010518:Periodontitis / Q000382:microbiology* / Q000628:therapy*; D016966:Porphyromonas gingivalis / Q000302:isolation & purification*; D011379:Prognosis; D016745:Root Planing; D014208:Treponema / Q000302:isolation & purification*
D015415:Biomarkers