title: The role of atrial natriuretic peptide in natriuresis of fasting.
abstract: OBJECTIVE
  To examine the relation between plasma atrial natriuretic peptide (ANP) and the natriuresis of fasting.
  
  
  METHODS
  ANP, aldosterone and renin were examined during natriuresis of fasting in 25 obese essential hypertensive patients and nine overweight normotensive subjects placed on a supervised 500-KCal diet composed of 50% carbohydrates, 30% fat and 20% protein, and unlimited salt. Twenty-four-hour urinary electrolytes were measured on days 0, 4, 7 and 10 of the diet.
  
  
  RESULTS
  Urinary sodium concentration nearly doubled in the patients on day 4, and increased 1.4-fold in the normotensive controls. Plasma ANP rose nearly threefold in the hypertensives on day 4 and nearly doubled in the normotensives. Patients and controls showed similar patterns of natriuresis and ANP secretion during the diet.
  
  
  CONCLUSIONS
  We conclude that there is a clear association between ANP levels and natriuresis of fasting.
authors.affiliation: Chorley Hypertension Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: E
authors.initials: E
authors.lastname: Maoz
authors.forename: A
authors.initials: A
authors.lastname: Shamiss
authors.forename: E
authors.initials: E
authors.lastname: Peleg
authors.forename: M
authors.initials: M
authors.lastname: Salzberg
authors.forename: T
authors.initials: T
authors.lastname: Rosenthal
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000097:blood*; D005215:Fasting / Q000502:physiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009318:Natriuresis / Q000502:physiology*; D009765:Obesity / Q000150:complications / Q000503:physiopathology*; D012964:Sodium / Q000652:urine
chemical_list: D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012964:Sodium