title: [Myorelaxants and intracranial pressure (ICP) in neurosurgery. Preliminary clinical results of pipecurium bromide (Arduan) on ICP and on cerebral perfusion pressure (CPP)].
abstract: Pipecurium bromide, a new non-depolarizing myorelaxant, was administered intravenously, at a dose of 0.06 mg/kg, to 10 patients suffering from expansive endocranial lesions, who had been anesthetised to undergo neurosurgery. The following parameters were recorded simultaneously, before and after drug administration: intracranial pressure, mean arterial blood pressure, central venous pressure, heart rate and end tidal CO2. No statistically significant changes in the above parameters were observed following the administration of the myorelaxant; these observations, which were considered together with the long duration of action, confirm that pipecurium bromide is a valuable tool in anesthesia for neurosurgery.
authors.affiliation: Istituto di Anestesia e Rianimazione, Università degli Studi di Roma La Sapienza.
authors.forename: G
authors.initials: G
authors.lastname: Di Giugno
authors.forename: M
authors.initials: M
authors.lastname: Sanfilippo
authors.forename: P
authors.initials: P
authors.lastname: Orfei
authors.forename: G
authors.initials: G
authors.lastname: Rosa
mesh_terms: D000328:Adult; D000368:Aged; D015113:Androstane-3,17-diol / Q000031:analogs & derivatives* / Q000494:pharmacology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D006801:Humans; D007427:Intracranial Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D017300:Pipecuronium; D010879:Piperazines / Q000494:pharmacology*
chemical_list: D009466:Neuromuscular Blocking Agents; D010879:Piperazines; D017300:Pipecuronium; D015113:Androstane-3,17-diol
vernacular_title: Miorilassanti e pressione intracranica (PIC) in neurochirurgia. Risultati clinici preliminari del bromuro di pipecurium (Arduan) sulla PIC e sulla pressione di perfusione cerebrale (PPC).