Incorporation of a novel conformationally restricted tyrosine analog into a cyclic, delta opioid receptor selective tetrapeptide (JOM-13) enhances delta receptor binding affinity and selectivity.
Mosberg
H I
HI
College of Pharmacy, University of Michigan, Ann Arbor 48109-1065.
Kroona
H B
HB
D000595:Amino Acid Sequence; D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D006168:Guinea Pigs; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis / Q000494:pharmacology; D010649:Phenylalanine / Q000031:analogs & derivatives; D011957:Receptors, Opioid / Q000187:drug effects* / Q000378:metabolism; D013329:Structure-Activity Relationship; D014443:Tyrosine / Q000031:analogs & derivatives*
D009842:Oligopeptides; D011957:Receptors, Opioid; D014443:Tyrosine; D010649:Phenylalanine