[The characteristics of the minute fluctuations in haloperidol-induced catalepsy and the contribution of different sections of the striatum to their formation in rats].
After constant recording of haloperidol catalepsy in rats a rhythmic structure with waves of minute range was observed. On the basis of individual pharmacological sensitivity all rats may be divided in animals with strong rhythmic fluctuations but rapid tolerance (hyperkinetic type) and with weak rhythmicity but delayed adaptation to haloperidol (hypokinetic type). Oscillatory pattern of catalepsy increased after bilateral lesions of dorsal striatum and decreased after ventral striatectomy. As suggested, ventral striatum has a rhythmogenic function which conditions a more easy neuroleptic tolerance.
Arushanian
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EB
Popov
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AV
Popova
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AP
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D002375:Catalepsy / Q000139:chemically induced* / Q000503:physiopathology; D003342:Corpus Striatum / Q000187:drug effects* / Q000503:physiopathology; D004361:Drug Tolerance; D005260:Female; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D010507:Periodicity; D051381:Rats; D013997:Time Factors
D006220:Haloperidol
Osobennosti minutnykh kolebaniĭ galoperidolovoĭ katalepsii i vklad raznykh otdelov striatuma v ikh formirovanie u krys.