VIP inhibits CCK-induced gallbladder contraction involving a beta-adrenoceptor mediated pathway in the rainbow trout, Oncorhynchus mykiss, in vivo.
The effects of VIP on CCK-induced contractions of the gallbladder were studied in the rainbow trout, Oncorhynchus mykiss, in vivo. Gallbladder pressures were measured via a catheter inserted into the gallbladder, and drugs were injected through a catheter in the dorsal aorta. CCK-induced contractions of the gallbladder wall were reduced in a dose-dependent manner by VIP. The effect of VIP was inhibited by the beta-adrenergic antagonist sotalol, indicating an adrenergic link in the VIP inhibition of the CCK-induced contraction. It is suggested that activation of VIP nerves could facilitate postprandial filling/refilling of the gallbladder despite the increased plasma levels of CCK during this period.
Aldman
G
G
Department of Zoophysiology, University of Göteborg, Sweden.
Holmgren
S
S
D000818:Animals; D002766:Cholecystokinin; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D005704:Gallbladder / Q000502:physiology*; D016473:Gallbladder Emptying / Q000502:physiology; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D013015:Sotalol / Q000494:pharmacology; D014337:Trout / Q000502:physiology*; D014660:Vasoactive Intestinal Peptide / Q000502:physiology*
D011943:Receptors, Adrenergic, beta; D014660:Vasoactive Intestinal Peptide; D002766:Cholecystokinin; D013015:Sotalol