Calcitriol: a hematolymphopoietrope?
A MEDLINE search of the English-language literature was conducted using the indexing terms 'immunology, calcitriol and vitamin D' to identify studies indicating a role for calcitriol as a primary immunomodulator. Sixty-six papers published between January 1956 and June 1991 were identified. Forty-five of these reports are cited in this review. The data strongly suggest an endocrine, autocrine and/or paracrine role for calcitriol in immune regulation. No unifying hypothesis has yet emerged explaining this collection of data. This paper provides a brief review of immune properties currently attributed to calcitriol.
Neiberger
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D002117:Calcitriol / Q000276:immunology* / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D006801:Humans; D007111:Immunity, Cellular; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism; D008264:Macrophages / Q000276:immunology; D009000:Monocytes / Q000276:immunology / Q000378:metabolism; D018167:Receptors, Calcitriol; D011987:Receptors, Steroid / Q000378:metabolism
D016207:Cytokines; D018167:Receptors, Calcitriol; D011987:Receptors, Steroid; D002117:Calcitriol