Recent developments in the molecular cloning and characterization of hepatitis C and E viruses.
The molecular properties of the genomes of both hepatitis C virus (HCV) and hepatitis E virus (HEV), the major etiologic agents of non-A, non-B hepatitis, are briefly described. The organization of the genome of each of these viruses is discussed and compared to those of other related or distantly related viruses that contain single-stranded, positive-sense RNA genomes. In the case of HEV, the reactivity of expressed proteins and genetic divergence of geographically distinct isolates are also described within the context of sequence variation, type-common epitopes and type-specific epitopes.
Bradley
D W
DW
Hepatitis Branch, Centers for Disease Control, Atlanta, GA 30333.
Beach
M J
MJ
Purdy
M A
MA
D003001:Cloning, Molecular; D016679:Genome, Viral; D016174:Hepacivirus / Q000235:genetics*; D016752:Hepatitis E virus / Q000235:genetics*