title: Anterograde transport of HSV-1 and HSV-2 in the visual system.
abstract: The anterograde spread of herpesvirus in the visual system subsequent to retinitis has been observed clinically. We compared the ability of two well-studied Herpes simplex virus (HSV) strains to be transported in the anterograde direction in the hamster visual system: strain McIntyre, representing HSV-1, and strain 186, representing HSV-2. Intravitreal injection of HSV-2 labeled more retinorecipient neurons than did HSV-1, suggesting important type differences in the ability of HSV to infect retinorecipient neurons after intravitreal injection. The most likely explanation for our results is that HSV-2 is more efficiently adsorbed than HSV-1 in the retinal ganglion cells. Our results also suggest that HSV may be useful as an anterograde transneuronal tracer for neuroanatomical studies of the visual system.
authors.affiliation: Department of Anatomy and Cell Biology, University of Cincinnati College of Medicine, OH 45267-0521.
authors.forename: R B
authors.initials: RB
authors.lastname: Norgren
authors.forename: J H
authors.initials: JH
authors.lastname: McLean
authors.forename: H C
authors.initials: HC
authors.lastname: Bubel
authors.forename: A
authors.initials: A
authors.lastname: Wander
authors.forename: D I
authors.initials: DI
authors.lastname: Bernstein
authors.forename: M N
authors.initials: MN
authors.lastname: Lehman
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000382:microbiology; D002772:Cholera Toxin; D006224:Cricetinae; D006735:Horseradish Peroxidase; D007150:Immunohistochemistry; D016849:Keratitis, Herpetic / Q000382:microbiology / Q000635:transmission*; D008297:Male; D008647:Mesocricetus; D009457:Neuroglia / Q000382:microbiology; D018139:Simplexvirus; D014795:Visual Pathways / Q000382:microbiology*
chemical_list: D002772:Cholera Toxin; D006735:Horseradish Peroxidase