Alpha- and beta-adrenergic receptors in children with essential hypertension.
Platelet alpha 2- and lymphocyte beta-adrenergic receptors were examined in eight children aged 10-16 years with essential hypertension, and in 11 age-matched normotensive children. Both alpha 2- and beta-adrenergic receptor concentrations showed no significant differences between children with essential hypertension and normotensive children. According to other studies, physiological fluctuations in catecholamines determine lymphocyte beta-adrenergic receptor concentrations, although down-regulation in platelet alpha 2-adrenergic receptors has not been observed. The present findings suggest that there may be no abnormalities in alpha 2- and beta-adrenergic receptors in essential hypertension in childhood, although a hyperadrenergic state has been reported to be of some relevance to the pathogenesis of essential hypertension in young adolescents.
Uchiyama
M
M
Department of Pediatrics, Oita Medical University, Japan.
Hayakawa
H
H
Ogawa
T
T
D000293:Adolescent; D001792:Blood Platelets / Q000737:chemistry*; D002648:Child; D004082:Dihydroalprenolol; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D007564:Japan / Q000453:epidemiology; D008214:Lymphocytes / Q000737:chemistry*; D008297:Male; D011942:Receptors, Adrenergic, alpha / Q000737:chemistry*; D011943:Receptors, Adrenergic, beta / Q000737:chemistry*; D014316:Tritium
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D014316:Tritium; D004082:Dihydroalprenolol