Design of a functional hexapeptide antagonist of endothelin.
Cody
W L
WL
Department of Medicinal Chemistry, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan 48106.
Doherty
A M
AM
He
J X
JX
DePue
P L
PL
Rapundalo
S T
ST
Hingorani
G A
GA
Major
T C
TC
Panek
R L
RL
Dudley
D T
DT
Haleen
S J
SJ
D000595:Amino Acid Sequence; D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D016232:Endothelins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000494:pharmacology; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D007295:Inositol Phosphates / Q000378:metabolism; D008969:Molecular Sequence Data; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D009842:Oligopeptides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D010446:Peptide Fragments / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism; D017466:Receptors, Endothelin; D013329:Structure-Activity Relationship; D014661:Vasoconstriction / Q000187:drug effects
D016232:Endothelins; D007295:Inositol Phosphates; D009842:Oligopeptides; D010446:Peptide Fragments; D011956:Receptors, Cell Surface; D017466:Receptors, Endothelin; C076213:PD 142893; D016718:Arachidonic Acid