[Evaluation of the therapeutic activity of fluconazole in acute experimental infection caused by Trypanosoma cruzi].
On hand of information that fluconazole can inhibit Trypanosoma cruzi, infection, an experimental investigation in acutely infected mice treated with 200 mg/kg daily of this drug during one month was carried out. Parasitemia patency, blood culture, sub-inoculation and histologic examination were the parameters used to evaluate the potential therapeutic activity of the drug. The results did not confirm the hypothesis, but it would be desirable to conduct new trials with this and other imidazole compounds.
Campos
R
R
Laboratório de Investigação Médica Parasitologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo.
Amato Neto
V
V
Moreira
A A
AA
de Souza
H B
HB
Okumura
M
M
Pinto
P L
PL
Braz
L M
LM
Silva
M F
MF
Matsubara
L
L
D000208:Acute Disease; D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D014349:Trypanosoma cruzi / Q000187:drug effects
D015725:Fluconazole
Avaliação da atividade terapêutica do fluconazol na infecção aguda, experimental, pelo Trypanosoma cruzi.