Transient decrease in rat striatal D2 dopamine receptor mRNA level after acute haloperidol treatment.
Acute haloperidol administration decreases the number of rat striatal D2 dopamine receptor (D2-receptor). The potential involvement of decreased D2-receptor gene transcription in the above process was examined using Northern blot analysis. There was a dose- and time-dependent transient decrement in the level of striatal D2-receptor mRNA after haloperidol. The decrease in transcription may be mediated via blockade of D2-receptor, since S(-)-sulpiride but not the inactive enantiomer R(+)-sulpiride produced the inhibition.
Sakata
M
M
Laboratory of Neurosciences, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808.
Prasad
C
C
D000818:Animals; D015152:Blotting, Northern; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology*; D015536:Down-Regulation / Q000187:drug effects; D006220:Haloperidol / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D012333:RNA, Messenger / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D017448:Receptors, Dopamine D2 / Q000096:biosynthesis* / Q000187:drug effects / Q000235:genetics; D013997:Time Factors
D012333:RNA, Messenger; D017448:Receptors, Dopamine D2; D006220:Haloperidol