Venous and arterial endothelial cells respond differently to thrombin and its endogenous receptor agonist.
The effects of thrombin and a peptide mimicking the amino terminus of its receptor, Res (42-55), on vascular reactivity were compared in isolated canine blood vessels. In saphenous veins contracted with endothelin-1, both thrombin and Res (42-55) caused relaxation in rings with endothelium and contraction in rings without endothelium. In coronary arteries, thrombin caused similar responses while Res (42-55) only caused contraction. These data suggest that different thrombin receptors are present on venous and arterial endothelial cells.
Simonet
S
S
Institut de Recherches Servier, Division of Angiology, Suresnes, France.
Bonhomme
E
E
Laubie
M
M
Thurieau
C
C
Fauchère
J L
JL
Verbeuren
T J
TJ
D000595:Amino Acid Sequence; D000818:Animals; D003331:Coronary Vessels / Q000187:drug effects / Q000502:physiology; D004285:Dogs; D016232:Endothelins / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000502:physiology; D008969:Molecular Sequence Data; D009119:Muscle Contraction / Q000187:drug effects*; D010446:Peptide Fragments / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology*; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism; D018179:Receptors, Thrombin; D012501:Saphenous Vein / Q000187:drug effects / Q000502:physiology; D013917:Thrombin / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects
D016232:Endothelins; D010446:Peptide Fragments; D010455:Peptides; D011956:Receptors, Cell Surface; D018179:Receptors, Thrombin; C072032:thrombin receptor peptide (42-55); D013917:Thrombin