title: [The pharmacokinetic study of a daily dose of theophylline].
abstract: Theophylline pharmacokinetics, administered in tablets containing 600 mg in a sustained-release hydrophilic matrix for a once daily intake, was evaluated after being administered to 6 healthy volunteers during 7 days at 8 pm. Plasmatic levels at -2, 0, 2, 3, 4, 6, 8, 10, 12, 14, 18 and 24 hours in relation with 8 pm intake, were obtained at the 7th day of administration. A plasmatic curve was obtained with a maximum concentration at 12 hours of 10.18 mcg/ml, a minimum concentration of 3.27 mcg/ml and an area under the concentration/time curve of 198.4 mcg.h/ml. These data make it evident that the tablet studied shows a release profile without excessive peaks and an average concentration at steady state within therapeutical range, and suggests its use in asthma.
authors.affiliation: Area de Desarrollo Analítico y Farmacéutico, Laboratorios Bagó, Buenos Aires, Argentina.
authors.forename: H J
authors.initials: HJ
authors.lastname: Arenoso
authors.forename: L L
authors.initials: LL
authors.lastname: Dall
authors.forename: J L
authors.initials: JL
authors.lastname: Soutric
authors.forename: J
authors.initials: J
authors.lastname: Martin
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D012016:Reference Values; D013607:Tablets; D013806:Theophylline / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors
chemical_list: D013607:Tablets; D013806:Theophylline
vernacular_title: Estudio farmacocinético de una dosis diaria de teofilina.