[The cardiovascular effects after kainate administration into the caudal ventral sections of the medulla oblongata].
Kainate destruction of the caudal ventral medulla's neurons raised by 70-90% the level of arterial pressure within 1 hour in anesthetised rats, the heart rate decreasing by 25-30% at the same time. Presection of the vagus at the neck level prevented the development of bradycardia and accelerated the formation of systemic arterial hypertension after administration of kainic acid to the caudal ventral medulla. The role of the vagal component in transmission of control signals from the ventral medullary structures to the heart and vessels, is discussed.
Kul'chitskiĭ
V A
VA
Azev
O A
OA
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D007608:Kainic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects* / Q000502:physiology; D008845:Microinjections; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D014630:Vagus Nerve / Q000187:drug effects / Q000502:physiology
D007608:Kainic Acid
Kardiovaskuliarnye éffekty posle vvedeniia kainata v kaudal'nuiu chast' ventral'nykh otdelov prodolgovatogo mozga.