title: An evaluation of Technegas as a ventilation agent compared with krypton-81 m in the scintigraphic diagnosis of pulmonary embolism.
abstract: A ventilation agent that provides good quality lung images, which is cheap, easy to use and non-toxic, with a low radiation dose, has long been sought. Technegas, an ultrafine aerosol of technetium-99m-labelled carbon, was developed with these qualities in mind. We have studied Technegas in a clinical setting to evaluate some of these qualities. Twenty-five patients referred with a diagnosis of suspected pulmonary embolism were investigated during the same study using both krypton-81 m and Technegas as ventilation agents in conjunction with 99mTc-macroaggregated albumin as a perfusion agent. Technegas provided images which were of satisfactory quality. Images were obtained relatively easily and without discomfort to the patient, and Technegas has the advantage of always being available. A semi-quantitative regional assessment was employed which showed a good correlation (r = 0.499, P less than 0.001) between Technegas and krypton-81 m ventilation. We report on an effect not previously found to be significant, that is lung regions were better ventilated with Technegas than with krypton-81 m. This altered the diagnostic probability rating of pulmonary embolism in a number of patients (n = 3, 12%) compared with krypton-81 m. This effect was also noted in a further 8 patients (32%) without a change in the diagnostic probability. We offer possible explanations for this phenomenon.
authors.affiliation: Department of Nuclear Medicine, Guys Hospital, London, UK.
authors.forename: G
authors.initials: G
authors.lastname: Cook
authors.forename: S E
authors.initials: SE
authors.lastname: Clarke
mesh_terms: D005260:Female; D006108:Graphite; D006801:Humans; D007727:Krypton Radioisotopes; D008168:Lung / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D013670:Sodium Pertechnetate Tc 99m; D014692:Ventilation-Perfusion Ratio / Q000502:physiology
chemical_list: D007727:Krypton Radioisotopes; C056708:Technegas; D006108:Graphite; D013670:Sodium Pertechnetate Tc 99m