title: Effect of synthetic enantiomeric cannabinoids on platelet aggregation.
abstract: The effect of a synthetic pair of enantiomeric cannabinoids on platelet function was evaluated. The nonpsychotropic enantiomer, the 1,1-dimethylheptyl homolog of (+)-(3S,4S)-7-hydroxy-delta-6-tetrahydrocannabinol (HU-211), was found to be more active in inhibiting ADP-induced platelet aggregation than the highly psychotropic (-)-enantiomer (HU-210). The related (+)-(3R,4R) cannabinoid, HU-213, which lacks the 7-hydroxy moiety, exerted its inhibitory effect within a wider range of concentrations. The results indicate a differentiation between psychotropic activity and inhibition of platelet aggregation in the cannabinoid group of compounds.
authors.affiliation: Department of Clinical Biochemistry, Ben Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: I
authors.initials: I
authors.lastname: Nathan
authors.forename: G
authors.initials: G
authors.lastname: Agam
authors.forename: R
authors.initials: R
authors.lastname: Mechoulam
authors.forename: A
authors.initials: A
authors.lastname: Dvilansky
authors.forename: A A
authors.initials: AA
authors.lastname: Livne
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D010976:Platelet Count; D013237:Stereoisomerism
chemical_list: D010975:Platelet Aggregation Inhibitors; C079455:HU 213; D000244:Adenosine Diphosphate; D013759:Dronabinol; C062018:HU 211