Inactivation of the thyrotropin releasing hormone.
Thyrotropin Releasing Hormone (TRH; pyroGlu-His-Pro-NH2) is rapidly hydrolyzed at the pyroGlu-His bond by a heterogeneously distributed ectoenzyme and a TRH-degrading serum enzyme. For these enzymes, the high degree of substrate specificity, the tissue specific hormonal regulation, the unusual tissue and the heterogenous cellular distribution strongly suggests that they serve very specialized functions for the transmission of TRH signals at specific target sites.
Bauer
K
K
Max-Planck-Institut für experimentelle Endokrinologie, Hannover, Germany.
Schulz
M
M
D000818:Animals; D001921:Brain / Q000201:enzymology; D010450:Endopeptidases / Q000502:physiology*; D006801:Humans; D013116:Spinal Cord / Q000201:enzymology; D009435:Synaptic Transmission / Q000502:physiology*; D013973:Thyrotropin-Releasing Hormone / Q000037:antagonists & inhibitors* / Q000502:physiology
D013973:Thyrotropin-Releasing Hormone; D010450:Endopeptidases