[Experimental study on efficiency of enterosorbents in the combined treatment of iron-deficiency anemia in pregnancy].
Efficiency of anti-anemic drug Ferrum Lack when using it alone or together with enterosorbent Uvesorb has been studied on the model of iron deficiency anemia (IDA) in pregnant rats. It is stated that three-fold blood-letting in total volume of 6 ml carried out prior to pregnancy causes symptoms of IDA. Over a period of the whole pregnancy the concentration of hemoglobin and the concentration of erythrocytes were lower than in intact pregnant rats. Tissue hypoxia characterized by disturbance of terminal microcirculation, capillary tissue diffusion and oxygen utilization was observed in pregnant rats with anemia model. Dysfunctional shifts in the system lipid peroxidation (LPO)-antioxidant protection (AOP) as noncompensated process of free-radical oxidation of lipids were revealed in parallel. A comparative estimation of results from treatment in groups of animals which were given and not given enterosorbent Uvesorb together with anti-anemic drug Ferrum Lack permitted determining the presence of anti-anemic and antihypoxic effects in both groups, though the latter was more pronounced in animals which were given enterosorbent. Various results were revealed relative to changes in the LPO-AOP system. When using drug Ferrum Lack alone, the content of products of LPO-lipid hydroperoxides and malonic dialdehyde increased in blood, whereas in group of animals which were given enterosorbent the number of these products was observed to significantly decrease.
Tarakhovskyĭ
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MA
Ovchar
T T
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Soroka
I N
IN
D000747:Anemia, Hypochromic / Q000097:blood / Q000188:drug therapy*; D000818:Animals; D001810:Blood Volume; D015687:Cell Hypoxia / Q000187:drug effects; D004359:Drug Therapy, Combination; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D006454:Hemoglobins / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008954:Models, Biological; D009942:Organometallic Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D011134:Polysaccharides / Q000494:pharmacology / Q000627:therapeutic use*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000188:drug therapy*; D051381:Rats
D006454:Hemoglobins; D009942:Organometallic Compounds; D011134:Polysaccharides; C009766:ferrum lek
Eksperymentalńe obgruntuvannia dotsilńoski zastosuvannia enterosorbentiv u kompleksnomu likuvanni zalizodefitsytnoĭ anemiĭ vagitnykh.