Biodistribution of Lipiodol following hepatic arterial injection.
Thirteen patients undergoing selective coeliac angiography before insertion of an indwelling hepatic arterial cannula underwent injection of 3 ml radiolabelled Lipiodol (2 MBq 131I) into the hepatic artery at the end of the procedure. At subsequent laparotomy 1-9 days later, biopsies were taken from normal liver and metastases. The radioactivity of this material was measured to establish the tumour:liver ratios. Two patients with large metastases (> 10 cm in diameter) had low ratios. In the remainder, the median ratio at 24 h was 1.5:1 (range 1.1-2.5:1; n = 5) and 2.6:1 (range 1.5-64.0:1; n = 6) at 3-9 days. Four patients underwent single photon emission computed tomography, which confirmed selective retention of Lipiodol in small metastases, although no activity was detected in a large deposit (> 15 cm) 10 days after injection. The tumour:liver ratio in the other three patients increased from 3.0-5.6:1 on day 1 to 4.5-7.2:1 on day 6. This study suggests that Lipiodol may be a useful therapeutic delivery agent to small colorectal liver metastases.
Hind
R E
RE
University Surgical Unit, Southampton General Hospital, UK.
Loizidou
M
M
Perring
S
S
Fleming
J
J
Batty
V
V
Birch
S
S
Taylor
I
I
D006801:Humans; D007457:Iodine Radioisotopes / Q000378:metabolism; D007459:Iodized Oil / Q000493:pharmacokinetics*; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000556:secondary; D011859:Radiography; D015899:Tomography, Emission-Computed, Single-Photon
D007457:Iodine Radioisotopes; D007459:Iodized Oil