title: Immunoreactivity for the beta chain of the platelet-derived growth factor receptor in malignant mesothelioma and non-neoplastic mesothelium.
abstract: The results of an immunohistochemical study of platelet-derived growth factor receptor (PDGF-R) beta chain in human non-neoplastic mesothelium (35 cases) and in malignant mesothelioma (33 cases) using a murine monoclonal antibody are reported. In approximately half of the malignant mesotheliomas, there was immunoreactivity in the cytoplasm of the neoplastic cells for the beta chain of the PDGF-R. In some cases, there was also membrane immunoreactivity. There were no statistically significant differences between the various mesothelioma subtypes. Immunoreactivity for PDGF-R beta chain was absent in non-neoplastic mesothelium.
authors.affiliation: Department of Pathology, University Hospital Antwerp, University of Antwerp, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Ramael
authors.forename: C
authors.initials: C
authors.lastname: Buysse
authors.forename: J
authors.initials: J
authors.lastname: van den Bossche
authors.forename: K
authors.initials: K
authors.lastname: Segers
authors.forename: E
authors.initials: E
authors.lastname: van Marck
mesh_terms: D000818:Animals; D004848:Epithelium / Q000737:chemistry*; D006801:Humans; D007150:Immunohistochemistry; D008654:Mesothelioma / Q000737:chemistry* / Q000473:pathology; D051379:Mice; D010982:Platelet-Derived Growth Factor / Q000032:analysis*; D010997:Pleural Neoplasms / Q000737:chemistry* / Q000473:pathology; D011956:Receptors, Cell Surface / Q000032:analysis*; D017479:Receptors, Platelet-Derived Growth Factor
chemical_list: D010982:Platelet-Derived Growth Factor; D011956:Receptors, Cell Surface; D017479:Receptors, Platelet-Derived Growth Factor