[Demonstration of delta sleep inducing peptide in a strain of human small cell lung cancer by immunocytology].
The "delta sleep inducing peptide" (DSIP) is a regulatory peptide localized in the brain, the hypophysis and some endocrine cells of the gut. The present immunological study, performed with a monoclonal antibody to DSIP, provides evidence for the presence of DSIP-like immunoreactivity (DSIP-LI) in a strain of small cell carcinoma. The specificity of the immunoreaction was assessed by the tests using heterologous antigen known to be secreted by these cells. The DSIP could play a role in the course of this disease.
Paulin
C
C
C.P. Laboratoire d'Histologie, C.N.R.S.-U.R.A. n. 1454, Faculté de Médecine Lyon Sud, Oullins.
Charnay
Y
Y
D018288:Carcinoma, Small Cell / Q000378:metabolism* / Q000473:pathology; D003701:Delta Sleep-Inducing Peptide / Q000737:chemistry*; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000737:chemistry
D003701:Delta Sleep-Inducing Peptide
Mise en évidence par immunocytologie du delta sleep inducing peptide dans une lignée de cancer pulmonaire à petites cellules humain.