title: Effects of the diet consumed during the pregnancy on the lipids content in maternal and fetal rat lungs.
abstract: This study was designed to determine if the quantity of lipids in the diet fed to pregnant rats would affect the deposition of fat in the fetal lung. Wistar rats were fed with two different diets during pregnancy: Standard Diet (StD; 4.000 cal/g) and High Fat Carbohydrate Free Diet (HFCFD; 6.000 cal/g). The rats consumed daily the same amount of calories from these different diets. The concentrations of triglycerides (TG), phospholipids (PL), total, esterified and free cholesterol (TC, EC and FC, respectively) were determined in serum and lung from pregnant rats as well as from their 19 day old fetuses. In the serum of rats fed with HFCFD, the cholesterol concentration increased in relation to that of rats fed with StD. In pregnant rat lung, the PL concentrations decreased and the TC, EC and FC concentrations increased with HFCFD in relation to StD. The triglycerides were not modified in any case. The lipidic composition of the sera and fetal lung were not changed by the two diets consumed by pregnant rats. This may be a biological protective mechanism to assure an adequate synthesis of alveolar surfactant.
authors.affiliation: Cátedra de Anatomía y Fisiología, Facultad de Química, Bioquímica y Farmacia Universidad Nacional de San Luis, Argentina.
authors.forename: M S
authors.initials: MS
authors.lastname: Ojeda
authors.forename: N
authors.initials: N
authors.lastname: Gomez
authors.forename: M S
authors.initials: MS
authors.lastname: Gimenez
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D002788:Cholesterol Esters / Q000378:metabolism; D004032:Diet; D002149:Energy Intake; D005260:Female; D005333:Fetus; D050356:Lipid Metabolism; D008055:Lipids / Q000032:analysis; D008168:Lung / Q000196:embryology / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000378:metabolism
chemical_list: D002788:Cholesterol Esters; D008055:Lipids; D010743:Phospholipids; D011506:Proteins; D014280:Triglycerides; D002784:Cholesterol