Diverse receptors for fibroblast growth factors.
The development and maintenance of multicellular organisms requires a complex interplay between cells in different tissues. Many of the factors mediating cell-cell communication are polypeptides, which were originally identified because of their ability to stimulate cell growth. In addition to growth signalling several of these factors have been observed to modulate cell survival, chemotaxis and differentiation both in vitro and in vivo. Fibroblast growth factors are a good example of polypeptide mitogens eliciting a wide variety of responses depending on the target cell type. Our knowledge of the cell surface receptors mediating the effects of FGFs has recently expanded remarkably. Perhaps not surprisingly, the complexity of the FGF family and FGF induced responses is reflected as diversity and redundancy of the FGF receptors.
Partanen
J
J
Department of Pathology, University of Helsinki, Finland.
Vainikka
S
S
Korhonen
J
J
Armstrong
E
E
Alitalo
K
K
D000595:Amino Acid Sequence; D000818:Animals; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000378:metabolism*; D015870:Gene Expression; D006801:Humans; D008024:Ligands; D008969:Molecular Sequence Data; D005810:Multigene Family; D011485:Protein Binding; D011956:Receptors, Cell Surface / Q000145:classification* / Q000235:genetics / Q000378:metabolism; D017468:Receptors, Fibroblast Growth Factor; D016415:Sequence Alignment; D015398:Signal Transduction
D008024:Ligands; D011956:Receptors, Cell Surface; D017468:Receptors, Fibroblast Growth Factor; D005346:Fibroblast Growth Factors