Improving placental blood flow in pre-eclampsia with prostaglandin A1.
Prostaglandin A1 is a potent hypotensive, peripheral vasodilator, a weak oxytocic, antiplatelet aggregator. It improves the renal hemodynamics. Its effect on placental circulation was evaluated (expressed as systolic/diastolic ratio and umbilical artery resistance index) in 20 women with severe pre-eclampsia and 10 normotensive pregnant women, by using the Doppler technique. Moreover, another 10 women with severe pre-eclampsia received dextrose 5% as a placebo for comparative purposes. Significant improvements in both parameters studied were observed in the women with severe pre-eclampsia. The beneficial changes differed significantly from the recorded values when using dextrose in pre-eclampsia or prostaglandin A1 in normotensive subjects. Such promising data add another important perspective to prostaglandin A1 in severe pre-eclampsia and may open up new avenues for its use in other situations with compromised placental flow.
Toppozada
M
M
Department of Obstetrics and Gynecology, University of Alexandria, Egypt.
Medhat
I
I
Sallam
H
H
Ismail
A A
AA
el-Badawy
E S
ES
Abd Rabbo
S
S
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D003971:Diastole / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000098:blood supply; D006801:Humans; D010920:Placenta / Q000098:blood supply; D011225:Pre-Eclampsia / Q000188:drug therapy* / Q000503:physiopathology; D011247:Pregnancy; D011454:Prostaglandins A / Q000627:therapeutic use*; D012039:Regional Blood Flow; D013599:Systole / Q000187:drug effects; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000502:physiology; D014655:Vascular Resistance / Q000187:drug effects
D011454:Prostaglandins A