Quantitative autoradiographic analysis of muscarinic cholinergic and GABAA (benzodiazepine) receptors in the forebrain of rats flown on the Soviet Biosatellite COSMOS 2044.
The quantitative autoradiographic analysis of muscarinic cholinergic and GABAA (benzodiazepine) receptors was performed on selected regions of the cerebral cortex and striatum of rats flown in the Soviet Biosatellite COSMOS 2044. An age- and strain-matched synchronous ground-based control group was employed for comparison. Muscarinic cholinergic receptor density was found to be significantly lower in the striatum of the flight animals as compared with that in the synchronous control group. No significant differences between flight and synchronous control groups were found in the other regions examined. GABAA (benzodiazepine) receptors showed no significant differences between the flight and control groups in any of the regions sampled. Although additional studies are needed to reach definitive conclusions, the decrease in muscarinic cholinergic receptors observed in the striatum suggests spaceflight-related alterations in motor activity.
Hyde
T M
TM
Clinical Brain Disorders Branch, NIMH, St. Elizabeth's, Washington, DC 20032.
Wu
L C
LC
Krasnov
I B
IB
Sigworth
S K
SK
Daunton
N G
NG
D'Amelio
F
F
D000818:Animals; D001345:Autoradiography; D003975:Diazepam / Q000378:metabolism*; D009928:Organ Specificity; D016548:Prosencephalon / Q000378:metabolism*; D011813:Quinuclidinyl Benzilate / Q000378:metabolism*; D051381:Rats; D011963:Receptors, GABA-A / Q000032:analysis / Q000378:metabolism*; D011976:Receptors, Muscarinic / Q000032:analysis / Q000378:metabolism*; D013026:Space Flight; D014316:Tritium
D011963:Receptors, GABA-A; D011976:Receptors, Muscarinic; D014316:Tritium; D011813:Quinuclidinyl Benzilate; D003975:Diazepam