DNA image cytometry in stomach carcinoma. Its relation to histomorphologic parameters and its influence on prognosis.
BACKGROUND
The influence of DNA content on the prognosis in stomach cancer is controversial.


METHODS
After curative resection of stomach carcinomas (adenocarcinomas [n = 58]; signet ring cell carcinomas [n = 24]; undifferentiated carcinomas [n = 21]), the influence of the DNA content and histomorphologic parameters on the prognosis was examined.


RESULTS
In the multivariate regression analysis, the prognosis depended on the lymph node status (P = 0.0009), pT stage (P = 0.02), tumor localization (P = 0.03), and histologic type (P = 0.05). The prognosis was independent of the DNA content. Furthermore, the degree of differentiation, operative procedure, safety distance, size of the tumor, and sex and age of the patient also did not influence the prognosis.


CONCLUSIONS
The DNA content of the tumor cells in stomach carcinoma does not influence prognosis.
Böttger
T C
TC
Department of Abdominal and General Surgery, Johannes Gutenberg-University of Mainz, Germany.
Gabbert
H
H
Stöckle
T C
TC
Wellek
S
S
Jauckus
C
C
Grenz
A
A
Junginger
T
T
D000230:Adenocarcinoma / Q000235:genetics / Q000401:mortality / Q000473:pathology; D002288:Adenocarcinoma, Mucinous / Q000235:genetics / Q000401:mortality / Q000473:pathology; D002277:Carcinoma / Q000235:genetics / Q000401:mortality / Q000473:pathology; D003592:Cytophotometry; D004273:DNA, Neoplasm / Q000032:analysis*; D006801:Humans; D011379:Prognosis; D013223:Statistics as Topic; D013274:Stomach Neoplasms / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D016019:Survival Analysis
D004273:DNA, Neoplasm