title: Sequence of the nucleocapsid protein gene of Machupo virus: close relationship with another South American pathogenic arenavirus, Junín.
abstract: The sequence of the nucleocapsid (N) protein of Machupo virus (causative agent of Bolivian haemorrhagic fever) has been determined, and used to infer a phylogenetic relationship to other arenaviruses. The relationship of the virus to Junín and Tacaribe viruses, together with previous demonstrations of antigenic similarity and cross-protection by heterologous viruses, suggest that vaccines developed against Argentine haemorrhagic fever might also be effective against the Bolivian disease.
authors.affiliation: Public Health Laboratory Service, Centre for Applied Microbiology and Research, Salisbury, U.K.
authors.forename: C M
authors.initials: CM
authors.lastname: Griffiths
authors.forename: S M
authors.initials: SM
authors.lastname: Wilson
authors.forename: J C
authors.initials: JC
authors.lastname: Clegg
mesh_terms: D000595:Amino Acid Sequence; D006477:Arenaviruses, New World / Q000145:classification / Q000235:genetics*; D001483:Base Sequence; D002213:Capsid / Q000235:genetics*; D004279:DNA, Viral; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral; D014758:Viral Core Proteins / Q000235:genetics*
chemical_list: D004279:DNA, Viral; D012367:RNA, Viral; D014758:Viral Core Proteins