Hypertensive therapy--effect on coronary risk factors.
Antihypertensive agents, particularly diuretics and beta-blockers, can "worsen" certain coronary risk factors, e.g. plasma lipids, which could theoretically offset the benefit of lowering blood pressure. However, the use of such surrogate markers may be inappropriate; propranolol has been shown to significantly decrease the frequency of myocardial infarction (MI) as evidenced by the appearance of Q-waves on ECG, and diuretics have significantly reduced the frequency of clinical MI in the elderly patient with isolated systolic hypertension.
Hansson
L
L
Department of Medicine, University of Göteborg, Ostra Hospital, Sweden.
D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D003327:Coronary Disease / Q000139:chemically induced* / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D012307:Risk Factors
D000959:Antihypertensive Agents