Humoral factors in chronic heart failure. A review.
In chronic heart failure, dysregulation of sympathetic nerve system activity and of release of several neurohormones is present. Increased plasma levels of circulating hormones together with other factors have a negative influence on myocardial beta adrenergic receptors and induce cardiac hypertrophy with myocardial fibrosis. ACE inhibitors possess an ability to reverse these phenomena. An endogenous factor with an ACE inhibitory ability was isolated from the bovine left ventricular myocardium.
Kölbel
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1st Department of Medicine, 2nd Medical School, Charles University, Prague, Czechoslovakia.
D006333:Heart Failure / Q000503:physiopathology*; D006439:Hemodynamics / Q000502:physiology*; D006728:Hormones / Q000097:blood*; D006801:Humans; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D012084:Renin-Angiotensin System / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D006728:Hormones; D011943:Receptors, Adrenergic, beta