title: Herpes simplex types 1 and 2: latency in the genital tract of guinea pigs.
abstract: Guinea pigs were infected with herpes simplex virus (HSV) intravaginally and then sacrificed during latent infection. Virus was recovered from the ganglia, spinal cord and genital tissues by co-cultivation after 1-6 weeks in culture. The virus could not be recovered from the genital tract during the first week of co-cultivation, nor from homogenized genital tissue. Cultivation of genital tissues with acyclovir did not reduce the recovery of HSV. Thus, HSV appeared to establish a truly latent infection in the genital tract and not a persistent infection as previously described.
authors.affiliation: Virology Laboratory, Veterans Affairs Medical Center, West Haven, CT 06516.
authors.forename: M L
authors.initials: ML
authors.lastname: Landry
authors.forename: C
authors.initials: C
authors.lastname: Bull
mesh_terms: D000212:Acyclovir / Q000494:pharmacology; D000818:Animals; D005260:Female; D005724:Ganglia / Q000382:microbiology; D005836:Genitalia, Female / Q000382:microbiology*; D006168:Guinea Pigs; D006561:Herpes Simplex / Q000382:microbiology; D018139:Simplexvirus / Q000302:isolation & purification*; D013116:Spinal Cord / Q000382:microbiology
chemical_list: D000212:Acyclovir