title: [Preoperative regional radiofrequency thermochemotherapy of colorectal cancer: clinical and pathological studies].
abstract: Thirty patients with advanced colorectal cancer were treated preoperatively by combined regional radiofrequency hyperthermia and 5-FU. After the treatment, the gross tumor regressive rate was 76.7%, and the tumor integral resection rate of colorectal cancer was 92.3%. Nine patients with advanced colorectal cancer, considered unoperable and treated with thermochemotherapy, underwent a successful en bloc resection of their tumors. Marked destruction of cancer cells was observed after thermochemotherapy. Moderate-severe damage of cancer cells was observed in 76.9% of patients in the thermochemotherapy group, 33.3% in the chemotherapy group, and 42.3% in the operation group (P less than 0.005). The results indicate that the treatment is more effective in the treatment of colorectal cancer than 5-FU chemotherapy alone.
authors.affiliation: 421st Hospital of People's Liberation Army.
authors.forename: G R
authors.initials: GR
authors.lastname: Wu
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000628:therapy*; D002288:Adenocarcinoma, Mucinous / Q000473:pathology / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D015179:Colorectal Neoplasms / Q000473:pathology / Q000628:therapy*; D003972:Diathermy / Q000379:methods*; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011300:Preoperative Care
chemical_list: D005472:Fluorouracil