Copper-zinc superoxide dismutase in cerebrospinal fluid: implications for oxygen-radical stress in the central nervous system.
We determined the concentration of copper zinc superoxide dismutase (CuZnSOD) in cerebrospinal fluid (CSF) and plasma of 36 persons without neurological illness or with various central and peripheral nervous system disorders not supposed to generate abnormal radical formation. The CuZnSOD concentration in CSF was significantly higher compared with plasma, suggesting the presence of a high oxygen-radical load on the central nervous system. Our data may be considered to reflect normal values.
Laboyrie
P M
PM
Department of Neurology, University Hospital, State University Leiden, The Netherlands.
Roos
R A
RA
Verspaget
H W
HW
D000328:Adult; D001921:Brain / Q000201:enzymology*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration / Q000502:physiology*; D012016:Reference Values; D013482:Superoxide Dismutase / Q000134:cerebrospinal fluid*
D013482:Superoxide Dismutase