[The effect of mefenamic acid on the immunity indices and hemostatic system in cancer patients and on the cathepsin D-like protease activity in the tissues in cancer of the large intestine].
The study of the effect of sodium mefenaminate on radiation resistance of rats yielded positive results. Clinical investigations showed mefenamic acid to decrease the activity of cathepsin D-like protease in colonic cancer tissue. The acid failed to affect the proteolytic activity of the normal mucosa. It revealed an immunomodulating activity and influenced the hemostatic system which usually manifested itself in amelioration of hypercoagulation.
Kliachkin
B M
BM
Basargin
S T
ST
Timofeev
I V
IV
Khaliulin
Iu G
IuG
Dorofeev
S A
SA
Alekseenko
L D
LD
Gumeniuk
M L
ML
D000276:Adjuvants, Immunologic / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D002402:Cathepsin D / Q000187:drug effects* / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000097:blood / Q000188:drug therapy / Q000201:enzymology / Q000276:immunology*; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007371:Interferon-gamma / Q000097:blood / Q000187:drug effects; D008175:Lung Neoplasms / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D008528:Mefenamic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000401:mortality / Q000517:prevention & control
D000276:Adjuvants, Immunologic; D008528:Mefenamic Acid; D007371:Interferon-gamma; D002402:Cathepsin D
Vliianie mefenaminovoĭ kisloty na pokazateli immuniteta, sistemu gemostaza onkologicheskikh bol'nykh i na aktivnost' proteazy, podobnoĭ katepsinu D, v tkani raka tolstoĭ kishki.