title: Isolation of Getah virus from mosquitos collected on Hainan Island, China, and results of a serosurvey.
abstract: An isolate of Getah virus was obtained from Culex mosquitos collected in Mao'an Village, Baoting County, Hainan Province, China, in 1964. The virus (strain M-1) replicated in laboratory-bred Aedes aegypti and Cx. fatigans (= quinquefasciatus), and was transmitted by laboratory-bred Ae. albopictus to healthy newborn albino mice. Skeletal muscles of newborn albino mice experimentally infected with the virus showed degeneration, atrophy, necrosis, and inflammatory changes of muscle fibers. Antibody prevalence in humans and animals ranged from 10.3% by neutralization tests of samples from healthy people in 1979 to 26.4% by CF tests of samples from people with febrile illnesses in 1982. The high prevalence of antibody in pigs, horses, and goats (17.6% to 37.5%) indicated that infection with Getah or a closely related virus is relatively common in domestic animals.
authors.affiliation: Chinese Academy of Preventive Medicine Institute of Virology, Beijing.
authors.forename: X D
authors.initials: XD
authors.lastname: Li
authors.forename: F X
authors.initials: FX
authors.lastname: Qiu
authors.forename: H
authors.initials: H
authors.lastname: Yang
authors.forename: Y N
authors.initials: YN
authors.lastname: Rao
authors.forename: C H
authors.initials: CH
authors.lastname: Calisher
mesh_terms: D000293:Adolescent; D000328:Adult; D000524:Alphavirus / Q000145:classification / Q000276:immunology / Q000302:isolation & purification*; D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000097:blood*; D002681:China; D003465:Culex / Q000382:microbiology*; D006041:Goats / Q000382:microbiology; D006736:Horses / Q000382:microbiology; D006801:Humans; D051379:Mice; D008875:Middle Aged; D015995:Prevalence; D016036:Seroepidemiologic Studies; D012698:Serologic Tests; D013552:Swine / Q000382:microbiology; D014036:Togaviridae Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology / Q000635:transmission
chemical_list: D000914:Antibodies, Viral