title: Association between leprosy and hepatitis B infection. A survey in Goiânia, central Brazil.
abstract: This investigation presents the results of hepatitis B virus screening among leprosy patients conducted in central Brazil as a preliminary information for a HBV vaccination programme. The main objectives were to assess the seroprevalence of HBV serum markers among lepromatous patients and to analyse institutionalization as risk factor for HBV infection in this population. Two groups of lepromatous patients were studied, 83 outpatients and 171 institutionalized ones. Screening for HBV serum markers included the detection of HBsAg, anti-HBc by radioimmune assay (RIA). The prevalence of carrier state (HBsAg) was 4.8% and 8.8% among outpatients and institutionalized, respectively, (p > 0.05). Seroprevalence of exposure (all markers) was statistically significant different between outpatients (16.9%) and institutionalized ones (50.3%). Institutionalized patients had an almost four fold risk of HBV infection when compared to the outpatients, and the highest risks were among patients with more than 21 years of residence in the colony, after adjusting for age and sex.
authors.affiliation: Unity of Hepatology, Hospital das Clínicas/UFG, Goiânia, Brazil.
authors.forename: H
authors.initials: H
authors.lastname: Rosa
authors.forename: A P
authors.initials: AP
authors.lastname: Costa
authors.forename: M L
authors.initials: ML
authors.lastname: Ferraz
authors.forename: S C
authors.initials: SC
authors.lastname: Pedroza
authors.forename: A L
authors.initials: AL
authors.lastname: Andrade
authors.forename: C M
authors.initials: CM
authors.lastname: Martelli
authors.forename: F
authors.initials: F
authors.lastname: Zicker
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001938:Brazil / Q000453:epidemiology; D002648:Child; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology* / Q000276:immunology; D006510:Hepatitis B Antibodies / Q000097:blood; D006511:Hepatitis B Antigens / Q000097:blood; D006801:Humans; D007297:Inpatients / Q000706:statistics & numerical data; D007918:Leprosy / Q000453:epidemiology* / Q000276:immunology; D015439:Leprosy, Borderline / Q000453:epidemiology / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010045:Outpatients / Q000706:statistics & numerical data; D015995:Prevalence; D016036:Seroepidemiologic Studies
chemical_list: D015415:Biomarkers; D006510:Hepatitis B Antibodies; D006511:Hepatitis B Antigens