[Antihypertensive effects of highly active atrial natriuretic peptide (haANP) infusion in patients with pregnancy-induced hypertension].
To study the antihypertensive effects of a new synthetic highly active atrial natriuretic peptide (haANP), the effects were observed in patients with moderate and severe pregnancy-induced hypertension (PIH). There were significant decreases in blood pressure (BP) for 10 min after haANP infusion (from 20.46 +/- 1.04/14.15 +/- 1.59 kPa to 18.17 +/- 0.60/11.08 +/- 1.36 kpa; P less than 0.05). 90 min after haANP infusion, BP decrease was the lowest (to 16.00 +/- 1.21/10.5 +/- 0.71 kPa; P less than 0.01), while plasma ANP levels increased 11 folds (from 47.5 +/- 5.5 ng/L to 525.4 +/- 15.6 ng/L). The effects continued for 300 minutes. Antihypertensive effects of magnesium sulphate were relatively relaxed (compared with those of haANP). The results showed strong and rapid antihypertensive effects of haANP. We found that mean RA and ALD levels were significantly decreased after haANP.
Zhang
L
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2nd Hospital, Fourth Military Medical University, Xian.
D000328:Adult; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D009320:Atrial Natriuretic Factor / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D011225:Pre-Eclampsia / Q000188:drug therapy* / Q000503:physiopathology; D011247:Pregnancy; D012084:Renin-Angiotensin System / Q000187:drug effects
D000959:Antihypertensive Agents; D009320:Atrial Natriuretic Factor