title: Relative role of B and T lymphocytes in pathogenesis of a murine herpes virus.
abstract: Pathogenesis of a murine herpes virus was investigated in inbred strains (BALB/c, CBA, AKR and C57BL/10) of mice. After intranasal inhalation, virus was found to replicate primarily in the lungs, followed by haematogenous spread to the target organs (adrenal glands and ganglia). AKR (H-2k) were found to be most susceptible to virus infection while CBA (H-2k) mice appeared to be relatively resistant. Infection of B-cell depleted BALB/c mice resulted in detection of lower lung virus titres in B-cell depleted animals as compared to normal intact mice. Moreover, 3 of 12 normal mice in untreated group died of virus infection while deaths did not occur in the B-cell depleted group. Results of T-cell subset depletion experiments in BALB/c mice revealed maximum mortality in the group depleted of both Lyt-2+ and L3T4+ subpopulations. Infectious virus titres were also higher in lungs of T-cell depleted animals.
authors.affiliation: Department of Pathology, Cambridge, U.K.
authors.forename: A K
authors.initials: AK
authors.lastname: Kapoor
authors.forename: A A
authors.initials: AA
authors.lastname: Nash
authors.forename: P
authors.initials: P
authors.lastname: Wildy
authors.forename: J
authors.initials: J
authors.lastname: Phelan
authors.forename: S
authors.initials: S
authors.lastname: Henney
authors.forename: P
authors.initials: P
authors.lastname: Rebello
authors.forename: D
authors.initials: D
authors.lastname: Blaskovic
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D006564:Herpesviridae / Q000472:pathogenicity*; D006566:Herpesviridae Infections / Q000276:immunology*; D008212:Lymphocyte Depletion; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*