Lacidipine: a dihydropyridine calcium antagonist with antioxidant activity.
Lacidipine, a new, long-acting antihypertensive dihydropyridine calcium antagonist was tested for potential antioxidant effect in a series of tests that consider specific radical species. A direct quenching of several radical species could be measured. Moreover, in biological membranes deriving from rat brain tissue, lacidipine showed an activity comparable to reference antioxidant compounds like vitamin E.
van Amsterdam
F T
FT
Glaxo Research Laboratories, Verona, Italy.
Roveri
A
A
Maiorino
M
M
Ratti
E
E
Ursini
F
F
D000818:Animals; D000975:Antioxidants; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D004095:Dihydropyridines / Q000494:pharmacology*; D004347:Drug Interactions; D005609:Free Radicals; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D016877:Oxidants; D051381:Rats; D011919:Rats, Inbred Strains; D013481:Superoxides / Q000737:chemistry
D000975:Antioxidants; D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D005609:Free Radicals; D016877:Oxidants; D013481:Superoxides; C060285:lacidipine