[Determination of the protonation constants of pipecuronium bromide on the basis of optical rotation as a function of pH values].
Pipecuronium bromide molecule contains two slightly basic nitrogen atoms in its two piperazine rings. Their pK values are quite similar to each other in consequence of their almost equivalent surroundings. Although the potentiometric titration used mostly for determination of pK values of organic compounds can be performed in this case too, but the polarimetric titration applied by us is more advantageous. Change of pH considerably influences the values of optical rotation; consequently, the curve obtained in this way is more utilizable than that of potentiometric titration. Protonation of two nitrogen atoms one after the other changes the optical rotation of the molecule in opposite direction. Consequently, a minimum can be seen on the curve of optical rotation versus pH value. The exact pK values were determined on the basis of the estimated parameters of a curve established corresponding to an equation and fitted to the measuring points. The sequence of deprotonation of nitrogen atoms could only be ascertained on the basis of the curves of polarimetric titration of compounds containing one piperazine ring; on the basis of the pK values and of the changing direction of optical rotation.
Bertháné
S Z
SZ
Richter Gedeon Vegyészeti Gyár Rt., Budapest.
Papné
S Z
SZ
D015113:Androstane-3,17-diol / Q000031:analogs & derivatives* / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D009466:Neuromuscular Blocking Agents / Q000737:chemistry*; D009904:Optical Rotation; D017300:Pipecuronium; D010879:Piperazines / Q000737:chemistry*; D011522:Protons
D009466:Neuromuscular Blocking Agents; D010879:Piperazines; D011522:Protons; D017300:Pipecuronium; D015113:Androstane-3,17-diol
A pipecuronium bromid protonálódási állandóinak meghatározása optikai forgatóképességének pH függése alapán.