Serotonin enhances the beta-adrenergic response in rat brain cortical slices.
Serotonin increased the isoproterenol-induced cyclic AMP accumulation in rat brain cortical slices but did not itself stimulate the production of cyclic AMP in this area. This effect appeared to be inhibited by the 5-HT2 receptor antagonist, ritanserin. This potentiation was not observed in the hippocampus. These data reinforce the hypothesis of a coupling between the noradrenergic and serotonergic systems, which may be involved in the mechanism of action of antidepressant drugs.
Morin
D
D
Département de Pharmacologie, Faculté de Médecine de Paris XII, Créteil, France.
Sapena
R
R
Zini
R
R
Tillement
J P
JP
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects*; D000242:Cyclic AMP / Q000096:biosynthesis / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology*; D013268:Stimulation, Chemical
D000928:Antidepressive Agents; D011943:Receptors, Adrenergic, beta; D012701:Serotonin; D000242:Cyclic AMP; D007545:Isoproterenol