Opiate total synthesis and contemporary NIDDK analgesic research-natural and unnatural ligands for computed tomography imaging of receptors in conscious humans. Implications for future advances in the neurosciences.
Rice
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Laboratory of Medicinal Chemistry, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.
D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D004723:Endorphins / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D008024:Ligands; D009316:National Institutes of Health (U.S.); D009462:Neurology; D011957:Receptors, Opioid / Q000187:drug effects*; D012106:Research; D014057:Tomography, X-Ray Computed; D014481:United States
D000700:Analgesics; D004723:Endorphins; D008024:Ligands; D011957:Receptors, Opioid