Immunoreactivity for the beta chain of the platelet-derived growth factor receptor in malignant mesothelioma and non-neoplastic mesothelium.
The results of an immunohistochemical study of platelet-derived growth factor receptor (PDGF-R) beta chain in human non-neoplastic mesothelium (35 cases) and in malignant mesothelioma (33 cases) using a murine monoclonal antibody are reported. In approximately half of the malignant mesotheliomas, there was immunoreactivity in the cytoplasm of the neoplastic cells for the beta chain of the PDGF-R. In some cases, there was also membrane immunoreactivity. There were no statistically significant differences between the various mesothelioma subtypes. Immunoreactivity for PDGF-R beta chain was absent in non-neoplastic mesothelium.
Ramael
M
M
Department of Pathology, University Hospital Antwerp, University of Antwerp, Belgium.
Buysse
C
C
van den Bossche
J
J
Segers
K
K
van Marck
E
E
D000818:Animals; D004848:Epithelium / Q000737:chemistry*; D006801:Humans; D007150:Immunohistochemistry; D008654:Mesothelioma / Q000737:chemistry* / Q000473:pathology; D051379:Mice; D010982:Platelet-Derived Growth Factor / Q000032:analysis*; D010997:Pleural Neoplasms / Q000737:chemistry* / Q000473:pathology; D011956:Receptors, Cell Surface / Q000032:analysis*; D017479:Receptors, Platelet-Derived Growth Factor
D010982:Platelet-Derived Growth Factor; D011956:Receptors, Cell Surface; D017479:Receptors, Platelet-Derived Growth Factor