Influence of the electrical stimulation of the medial amygdala on adrenocortical sensitivity to adrenocorticotrophin in hypophysectomized rats.
The effects of electrical stimulation of medial amygdala on the adrenocortical sensitivity to adrenocorticotrophin (ACTH) were investigated in hypophysectomized rats. The intravenous injection of ACTH increased the rates of 14C transfer from 14C-l-acetate into corticosterone and cortisol in the adrenal slices of hypophysectomized rats. The electrical stimulation of the medial amygdala produced a further increase in the rates of 14C transfer from 14C-l-acetate into corticosterone and cortisol. From these results, it might be suggested that the medial amygdala was capable of enhancing the adrenocortical steroidogenesis in response to ACTH.
Saito
H
H
Department of Physiology, Kochi Medical School, Nankoku, Japan.
Sato
T
T
Kaba
H
H
Okutani
F
F
Yu
G Z
GZ
Seto
K
K
Kimura
F
F
Kawakami
M
M
Roberts
S
S
D000085:Acetates / Q000378:metabolism; D000302:Adrenal Cortex / Q000187:drug effects* / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000679:Amygdala / Q000502:physiology*; D000818:Animals; D003345:Corticosterone / Q000378:metabolism; D004558:Electric Stimulation; D006854:Hydrocortisone / Q000378:metabolism; D007016:Hypophysectomy; D051381:Rats
D000085:Acetates; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone; D006854:Hydrocortisone