title: [Typhoid fever in school children: by what measures is the modification of the clinical course due to oral vaccination?].
abstract: The clinical course of infection by Salmonellae was compared between patients who had been vaccinated against typhoid fever using the Ty21a vaccine and those who had not. Of 2566 bacteriological confirmed cases 84% were infected with S typhi, 14% with S paratyphi B and 2% with S paratyphi A. Among patients with typhoid fever, 34% were treated in hospital, 3.5% had relapses, 5.4% developed complications and 1 patient died (0.05%). Among patients with paratyphoid fever, 18% were treated in hospital, 0.6% had relapses, 1.4% developed complications and there were no deaths. These figures were similar among vaccinated and non-vaccinated cases. A slightly greater proportion of vaccinated cases were treated in hospital (38 vs 30%). Thus, use of oral vaccination against typhoid fever does not alter the clinical course of infection with Salmonellae.
authors.affiliation: Programa de Control de Fiebre Tifoidea, Ministerio de Salud, Chile, Santiago.
authors.forename: R
authors.initials: R
authors.lastname: Contreras
authors.forename: C
authors.initials: C
authors.lastname: Ferreccio
authors.forename: V
authors.initials: V
authors.lastname: Sotomayor
authors.forename: L
authors.initials: L
authors.lastname: Astroza
authors.forename: G
authors.initials: G
authors.lastname: Berríos
authors.forename: E
authors.initials: E
authors.lastname: Ortiz
authors.forename: C
authors.initials: C
authors.lastname: Palomino
authors.forename: I
authors.initials: I
authors.lastname: Prenzel
authors.forename: M E
authors.initials: ME
authors.lastname: Pinto
authors.forename: M
authors.initials: M
authors.lastname: Levine
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D010284:Paratyphoid Fever / Q000453:epidemiology / Q000503:physiopathology* / Q000517:prevention & control; D012482:Salmonella paratyphi A; D012484:Salmonella paratyphi B; D014435:Typhoid Fever / Q000453:epidemiology / Q000503:physiopathology* / Q000517:prevention & control; D014436:Typhoid-Paratyphoid Vaccines / Q000008:administration & dosage
chemical_list: D014436:Typhoid-Paratyphoid Vaccines
vernacular_title: Fiebre tifoidea en escolares: en que medida la clinica es modificada por el uso de una vacuna oral?