Treatment of visceral leishmaniasis (kala-azar) with aminosidine (= paromomycin)-antimonial combinations, a pilot study in Bihar, India.
A 20 d drug regimen of aminosidine (= paromomycin) at 12 mg/kg/d in combination with sodium stibogluconate at 20 mg/kg/d proved efficacious and well-tolerated in patients with visceral leishmaniasis in the State of Bihar, India. Eighteen of 22 evaluable patients achieved an ultimate cure. The remaining 4 patients, although not cleared of parasites, had their parasite grade reduced and also improved clinically. This confirms prior findings in Kenyan patients with kala-azar, and indicates that this regimen is a valid alternative to antimonial compounds alone in the State of Bihar, where cases of kala-azar not responding to antimonial drugs and intolerant of pentamidine are increasingly recorded.
Thakur
C P
CP
Patna Medical College, Tripolia Social Service Hospital, India.
Olliaro
P
P
Gothoskar
S
S
Bhowmick
S
S
Choudhury
B K
BK
Prasad
S
S
Kumar
M
M
Verma
B B
BB
D000293:Adolescent; D000328:Adult; D000368:Aged; D000967:Antimony Sodium Gluconate / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007223:Infant; D007898:Leishmaniasis, Visceral / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010303:Paromomycin / Q000627:therapeutic use*; D010865:Pilot Projects
D010303:Paromomycin; D000967:Antimony Sodium Gluconate