title: [Small cell carcinoma of the bladder. Small cell lung cancer-associated ganglioside (Fuc GM1) expression].
abstract: A 61-year-old male visited us with chief complaints of macroscopic hematuria and bladder irritation symptoms. Cystoscope, U/S, MRI, and CT showed an extensive non-papillary, wide-based tumor centering around the anterior wall of the bladder. Transabdominal U/S-guided full-thickness biopsy indicated a pT3a (Biopsy) primary small cell carcinoma of the bladder containing neuroendocrine granules. Immunohistochemical studies revealed Fuc GM1, an antigen related to small cell carcinoma of the lung. Neoadjuvant therapy consisted of preoperative irradiation at 50 Gy and intra-arterial infusion chemotherapy with CDDP and THP. Since a follow-up full thickness biopsy indicated pT0 (Biopsy), total cystectomy was performed. Examination of the resected specimen also indicated pathological CR.
authors.affiliation: Department of Urology, Tohoku University School of Medicine.
authors.forename: M
authors.initials: M
authors.lastname: Satoh
authors.forename: S
authors.initials: S
authors.lastname: Orikasa
authors.forename: S
authors.initials: S
authors.lastname: Kawamura
authors.forename: C
authors.initials: C
authors.lastname: Ohyama
authors.forename: S
authors.initials: S
authors.lastname: Saitoh
authors.forename: Y
authors.initials: Y
authors.lastname: Chiba
authors.forename: H
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Mikami
authors.forename: R
authors.initials: R
authors.lastname: Ichinohazama
authors.forename: S
authors.initials: S
authors.lastname: Hakomori
mesh_terms: D018288:Carcinoma, Small Cell / Q000276:immunology* / Q000628:therapy; D003131:Combined Modality Therapy; D005677:G(M1) Ganglioside / Q000031:analogs & derivatives* / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000276:immunology* / Q000628:therapy
chemical_list: D005677:G(M1) Ganglioside; C039123:fucosyl GM1 ganglioside