Uptake of 2-fluoro-2-deoxy-D-[U-14C]-glucose during chemotherapy in murine Lewis lung tumor.
Mice bearing intramuscular Lewis lung tumor were treated with BCNU and doxorubicin (ADM) to study chemotherapy-induced changes in the uptake of 2-fluoro-2-deoxy-[U-14C]glucose (FDG). A decreased FDG uptake, tumor regression and a diminished proportion of aneuploid versus diploid cells as evaluated by DNA flow cytometry were seen after treatment with BCNU but not with ADM; HPLC indicated that most of the 14C activity in tumors was from FDG6-phosphate. The results suggest that changes in FDG uptake reflect the effectiveness of antitumor therapy. FDG may be valuable in follow-up studies of cancer treatment.
Minn
H
H
Department of Oncology and Radiotherapy, Turku University Central Hospital, Finland.
Kangas
L
L
Kellokumpu-Lehtinen
P
P
Klemi
P
P
Sipilä
H
H
Vuorinen
J
J
Härkönen
P
P
Lähde
M
M
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002330:Carmustine / Q000627:therapeutic use; D003847:Deoxyglucose / Q000031:analogs & derivatives* / Q000378:metabolism; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D005434:Flow Cytometry; D019788:Fluorodeoxyglucose F18; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D011877:Radionuclide Imaging
D019788:Fluorodeoxyglucose F18; D004317:Doxorubicin; D000255:Adenosine Triphosphate; D003847:Deoxyglucose; D005952:Glucose-6-Phosphatase; D002330:Carmustine