title: [ACTH-independent Cushing's syndrome due to bilateral macronodular adrenal hyperplasia with empty sella turcica and anterior panhypopituitarism].
abstract: A case is presented of Cushing's syndrome due to macronodular bilateral adrenal hyperplasia which is ACTH-independent as was demonstrated by the undetectable basal and after stimulation with metoprolol ACTH plasma levels. High cortisol levels is associated in this patient with empty sella turcica and anterior panhypopituitarism with confirm the exclusive adrenal origin of the hormone hypersecretion and the lack of treatment success with hypophysis ablation in this process.
authors.affiliation: Servicio de Endocrinología, Hospital de Navarra, Pamplona.
authors.forename: E L
authors.initials: EL
authors.lastname: Menéndez Torre
authors.forename: M T
authors.initials: MT
authors.lastname: López Carballo
authors.forename: R
authors.initials: R
authors.lastname: Rodríguez Erdozain
authors.forename: M
authors.initials: M
authors.lastname: Urbieta Echezarreta
authors.forename: J
authors.initials: J
authors.lastname: Lafita Tejedor
authors.forename: L
authors.initials: L
authors.lastname: Forga Llenas
mesh_terms: D000311:Adrenal Glands / Q000473:pathology*; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000368:Aged; D003480:Cushing Syndrome / Q000097:blood / Q000175:diagnosis*; D004652:Empty Sella Syndrome / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D006964:Hyperpituitarism / Q000097:blood / Q000175:diagnosis*; D006965:Hyperplasia / Q000097:blood / Q000175:diagnosis; D008797:Metyrapone; D010903:Pituitary Gland, Anterior
chemical_list: D000324:Adrenocorticotropic Hormone; D008797:Metyrapone
vernacular_title: Síndrome de Cushing ACTH-independiente por hiperplasia adrenal macronodular bilateral con silla turca vacía y panhipopituitarismo anterior.