Beta--CCE and FG 7142 increase defensiveness during intraspecies encounters in mice.
The effects were ascertained of two partial inverse agonists at benzodiazepine receptors (beta-CCE and FG 7142) on the incidence of timid (defensive-escape), aggressive, sociable and locomotor activities in both timid and aggressive singly-housed male mice, treated with drugs in paired interactions with untreated non-aggressive males. FG 7142 (5 mg/kg) and beta-CCE (8 mg/kg) increased defenses and escapes without producing other behavioral changes in timid mice. FG 7142 (20 mg/kg) and beta-CCE (1-8 mg/kg) moderately increased defenses and alert postures in aggressive mice and this effect was associated with marked reduction of aggressive behavior. FG 7142 (20 and 80 mg/kg) also decreased walking across cage in aggressive mice. It is concluded that beta-CCE and FG 7142 produced behavioral changes which could be interpreted as "anxiogenic".
Sulcová
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A
Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czechoslovakia.
Krsiak
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M
Donát
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D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001007:Anxiety / Q000139:chemically induced; D002243:Carbolines / Q000494:pharmacology*; D004924:Escape Reaction / Q000187:drug effects; D058787:GABA-A Receptor Antagonists; D007398:Interpersonal Relations; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects
D002243:Carbolines; D058787:GABA-A Receptor Antagonists; C035874:FG 7142; C024915:beta-carboline-3-carboxylic acid ethyl ester