Ca2+ influx through voltage- and purinoceptor-operated channels estimated from [Ca2+]c signals (myocytes from guinea-pig urinary bladder).
The rise in free cytosolic calcium was studied by a combination of the techniques of microspectrofluorometry and whole-cell patch clamp. By comparing the membrane currents with their effect on [Ca2+]c, the relative importance of Ca2+ influx could be quantified for both L-type Ca2+ channels and non-selective channels activated by extracellular ATP.
Isenberg
G
G
Department of Physiology, University of Cologne, Germany.
Ganitkevich VYa
Schneider
P
P
D000255:Adenosine Triphosphate / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism / Q000502:physiology*; D002478:Cells, Cultured; D006168:Guinea Pigs; D015640:Ion Channel Gating; D008564:Membrane Potentials / Q000187:drug effects; D009130:Muscle, Smooth / Q000502:physiology*; D011983:Receptors, Purinergic / Q000502:physiology*; D001743:Urinary Bladder / Q000502:physiology*
D015220:Calcium Channels; D011983:Receptors, Purinergic; D000255:Adenosine Triphosphate; D002118:Calcium