Sural nerve immunoreactivity for nerve growth factor receptor in a case of localized hypertrophic neuropathy.
Immunoreactivity for nerve growth factor receptor (NGFR) was examined using a monoclonal antibody against human NGFR in the sural nerve of a 24-year-old woman, affected by localized hypertrophic neuropathy (LHN). NGFR expression was correlated with electron microscopy and with immunoreactivity for S-100 protein, laminin, HLA-DR, HNK-1, P0 glycoprotein and neurofilament peptides. Our results indicate that in LHN most of whorl-forming cells are NGFR positive and S-100 protein or HLA-DR negative. These data along with the ultrastructural features suggest their origin from perineurium.
Sciacco
M
M
Institute of Neurology, Centro Dino Ferrari, University of Milan, Italy.
Scarpini
E
E
Baron
P L
PL
Doronzo
R
R
Moggio
M
M
Passerini
D
D
Scarlato
G
G
D000328:Adult; D005260:Female; D006801:Humans; D006984:Hypertrophy / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D009419:Nerve Tissue Proteins / Q000276:immunology / Q000378:metabolism; D009422:Nervous System Diseases / Q000276:immunology / Q000473:pathology*; D011956:Receptors, Cell Surface / Q000276:immunology / Q000378:metabolism*; D017475:Receptors, Nerve Growth Factor; D013497:Sural Nerve / Q000276:immunology / Q000473:pathology*
D009419:Nerve Tissue Proteins; D011956:Receptors, Cell Surface; D017475:Receptors, Nerve Growth Factor