Absence of linkage between the angiotensin converting enzyme locus and human essential hypertension.
The angiotensin converting enzyme (ACE) is a key component of the renin angiotensin system that contributes to the regulation of blood pressure (BP). Recent demonstration of linkage between the ACE locus and elevated BP in a rat model of hypertension has further emphasized ACE as a candidate gene in human hypertension. We report the localization of the ACE gene on the genetic map of chromosome 17, and identify an extremely polymorphic marker at the human growth hormone (hGH) locus which shows no recombination with ACE. We have found no evidence to support linkage between the ACE locus and hypertension, which suggests that mutations at the ACE locus do not commonly contribute to the pathogenesis of hypertension in our test population.
Jeunemaitre
X
X
Howard Hughes Medical Institute, University of Utah, Health Sciences Center, Salt Lake City 84112.
Lifton
R P
RP
Hunt
S C
SC
Williams
R R
RR
Lalouel
J M
JM
D001483:Base Sequence; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D004247:DNA / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D013006:Growth Hormone / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000201:enzymology / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D010375:Pedigree; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*
D005819:Genetic Markers; D013006:Growth Hormone; D004247:DNA; D007703:Peptidyl-Dipeptidase A