Histochemical and ultrastructural alterations of lysosomes and acid phosphatase reaction in human chronic hypoxic myocardium.
Histochemical and ultrastructural alterations of lysosomes and acid phosphatase reaction were assayed in myocardial human specimens from patients with some acquired and congenital cardiac affections and cardiac failure class II-IV (after NYHA classification). The optic and electron microscopic study of the acid phosphatase (the main lysosomal marker) activity reveals that the intensity and the distribution of the reaction were correlated with the degree of heart failure, being maximum at the IVth degree. The electron microscopic analysis of the lysosomal vacuolar apparatus emphasizes various changes also correlated with the intensity of hypoxia.
Butur
G
G
Victor Babeş, Institute, Bucharest, Romania.
Nicolau
N
N
Laky
D
D
D000135:Acid Phosphatase / Q000032:analysis*; D006330:Heart Defects, Congenital / Q000201:enzymology / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D008247:Lysosomes / Q000648:ultrastructure*; D008854:Microscopy, Electron; D017202:Myocardial Ischemia / Q000201:enzymology / Q000473:pathology*; D009206:Myocardium / Q000201:enzymology / Q000648:ultrastructure*
D000135:Acid Phosphatase