High and low affinity NGF receptor mRNAs in human foetal spinal cord and ganglia.
The cellular localization of mRNAs encoding the low affinity NGF receptor (here referred to as LANR) and the putative high affinity receptor for NGF, trk, have been studied in the human foetal spinal and sympathetic ganglia, and spinal cord, using in situ hybridization. The receptor mRNAs were highly expressed in the spinal and sympathetic ganglia, with most but not all neurons expressing both LANR and trk mRNA. Spinal nerve rootlets distal to the spinal ganglia expressed LANR but not trk mRNA, confirming the presence of the low affinity receptor in developing Schwann cells. In the spinal cord, LANR mRNA was found throughout the medial and lateral motor columns while, trk mRNA was detected in scattered cells in the dorsal aspect of developing grey matter.
Wetmore
C
C
Department of Histology, Karolinska Institute, Stockholm, Sweden.
Bygdeman
M
M
Olson
L
L
D005333:Fetus; D005727:Ganglia, Spinal / Q000196:embryology / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D009414:Nerve Growth Factors / Q000378:metabolism; D009474:Neurons / Q000502:physiology*; D015513:Oncogene Proteins / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000096:biosynthesis / Q000235:genetics*; D017475:Receptors, Nerve Growth Factor; D013116:Spinal Cord / Q000196:embryology / Q000502:physiology*
D009414:Nerve Growth Factors; D015513:Oncogene Proteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D017475:Receptors, Nerve Growth Factor; C065400:oncogene protein trk