Synthesis, structure, and stability of the zinc complex of the dimethyl ester of meso-2,3-dimercaptosuccinic acid.
The dimethyl ester of meso-2,3-dimercaptosuccinic acid (meso-DiMeDMSA) reacts with Zn2+ ions to form protonated and polynuclear complexes. The species [Zn2L3H]- and [Zn2L3]2- are formed at pH values between 3 and 6.5 and have overall formation constants of 10(37.53) and 10(32.52), respectively, whereas the mononuclear complex [ZnL2]2- is formed at physiological pH and has a formation constant of 10(18.06). The mononuclear complex was synthesized and isolated as an ion association complex with the tetramethylammonium ion, [(Me)4N]2[Zn(DiMeDMSA)2], and its structure in solution was determined by low-temperature 1H and 13C NMR spectroscopy. In this structure the Zn2+ ion is tetrahedrally coordinated to four thiolate groups from two meso-DiMeDMSA molecules.
Rivera
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Department of Chemistry, University of Arizona, Tucson 85721.
Fernando
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D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D011199:Potentiometry; D004113:Succimer / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D013696:Temperature; D015032:Zinc / Q000737:chemistry*
C060658:dimethyl mercaptosuccinate; D004113:Succimer; D015032:Zinc