title: Antisense oligonucleotides: inhibition of liver cell proliferation and in vivo disposition.
abstract: As oligomers inhibited hepatoma growth in vitro. These cells have oligomer-specific binding sites. The oligomers were taken up by liver and have potential for hepatic growth modulation in intact animals.
authors.affiliation: Department of Surgery, University of Pittsburgh, Pennsylvania 15261.
authors.forename: M
authors.initials: M
authors.lastname: Inagaki
authors.forename: K
authors.initials: K
authors.lastname: Togawa
authors.forename: B I
authors.initials: BI
authors.lastname: Carr
authors.forename: K
authors.initials: K
authors.lastname: Ghosh
authors.forename: J S
authors.initials: JS
authors.lastname: Cohen
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular; D002455:Cell Division / Q000187:drug effects*; D002461:Cell Line, Transformed; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D008099:Liver / Q000166:cytology*; D008113:Liver Neoplasms; D016376:Oligonucleotides, Antisense / Q000494:pharmacology*; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism; D051381:Rats; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D016376:Oligonucleotides, Antisense; D016271:Proto-Oncogene Proteins c-myc; D016212:Transforming Growth Factor beta