[Effect of cadmium on certain factors of lipid metabolism in the aorta and myocardium of rats].
The goal of the research was to examine the effects of cadmium chloride on the levels of selected components of the lipid metabolism in the homogenates of the aorta and the cardiac muscle. Our experiments were carried out on white rats of the Wistar breed subdivided into three experimental groups. Group I were the control animals. The rats of Group II and Group III received the doses of per os, water solution of the cadmium chloride, of 0.88 mg CdCl2 x 2.5H2O per kg of the body weight and 8.8 mg CdCl2 x 2.5H2O per kg of the body weight, respectively, 3 times a week for 3 months. The concentration of total cholesterol was determined in the aorta homogenates and the concentrations of free fatty acids, triglycerides, phospholipids and total cholesterol were determined in the cardiac muscle homogenates. On the basis of our results we found the increase of the total cholesterol concentrations in the aorta homogenates. We also observed the tendency to increase the total cholesterol level in the cardiac muscle homogenates. Such results indicate that atherosclerotic changes of vessels are possible in conclusion of a chronic cadmium poisoning. No changes in the concentrations of the lipid components which are energetically important for the heart were found. Besides, the decrease of the phospholipid concentration resulting from the cadmium chloride poisoning was observed in the cardiac muscle homogenates. That may indicate a change of the activities of the respective enzymatic systems in the cardiac muscle under the influence of cadmium which also causes damages of biological membranes.
Janik
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Miedzywydziałowej Katedry Patofizjologii, Akademii Medycznej im. M. Kopernika, Krakowie.
D000818:Animals; D001011:Aorta / Q000378:metabolism*; D002104:Cadmium / Q000494:pharmacology*; D019256:Cadmium Chloride; D002712:Chlorides / Q000494:pharmacology*; D002784:Cholesterol / Q000032:analysis; D050356:Lipid Metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D002712:Chlorides; D002104:Cadmium; D002784:Cholesterol; D019256:Cadmium Chloride
Wpływ kadmu na niektóre wskaźniki przemiany lipidowej w aorcie i mieśniu sercowym szczurów.