In-vitro activity of daptomycin against a worldwide collection of methicillin-resistant Staphylococcus aureus.
Minimum inhibitory and minimum bactericidal concentrations (MIC and MBC) of daptomycin and of vancomycin have been compared against 80 strains of methicillin-resistant Staphylococcus aureus isolated from many parts of the world. In the presence of 30 mg/l of Ca++, daptomycin at 4 mg/l killed all the strains tested, and was only slightly less active than vancomycin.
Brumfitt
W
W
Department of Medical Microbiology, Royal Free Hospital School of Medicine, London, UK.
Hamilton-Miller
J M
JM
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017576:Daptomycin; D014943:Global Health; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000494:pharmacology; D013045:Species Specificity; D013211:Staphylococcus aureus / Q000187:drug effects*; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D010455:Peptides; D014640:Vancomycin; D017576:Daptomycin