A G-rich sequence element common to Dictyostelium genes which differ radically in their patterns of expression.
Removal of a G-rich element from the DIF-inducible, prestalk-, and stalk-specific ecmB gene reduces expression but cell-type specificity is retained. The ecmB element will functionally substitute for a homologous sequence upstream of CP2, a cAMP-inducible gene and is bound by GBF, the factor which interacts with the CP2 G box. These results suggest that the G box may play a similar stimulatory role in these two independently regulated genes where it presumably interacts with different ancillary promoter elements.
Ceccarelli
A
A
Clare Hall Laboratories, Imperial Cancer Research Fund, Potters Bar, Herts, England.
Mahbubani
H J
HJ
Insall
R
R
Schnitzler
G
G
Firtel
R A
RA
Williams
J G
JG
D000818:Animals; D001483:Base Sequence; D000242:Cyclic AMP / Q000494:pharmacology; D004023:Dictyostelium / Q000235:genetics*; D015870:Gene Expression; D005809:Genes, Regulator; D008969:Molecular Sequence Data
D000242:Cyclic AMP