Opsoclonus-myoclonus with Beckwith-Wiedemann syndrome and hepatoblastoma.
The association between Beckwith-Wiedemann syndrome and hepatoblastoma is well established and relatively commonplace. The occurrence of opsoclonus-myoclonus syndrome in individuals with occult neoplasia is also well documented. However, the development of opsoclonus-myoclonus syndrome in an infant with Beckwith-Wiedemann syndrome and hepatoblastoma has not been reported previously. The list of underlying causes of opsoclonus-myoclonus syndrome should be expanded to include hepatoblastoma, particularly in any child with features suggestive of Beckwith-Wiedemann syndrome.
Wilfong
A A
AA
Department of Pediatric Neurology, Baylor College of Medicine, Texas Children's Hospital, Houston 77030.
Parke
J T
JT
McCrary
J A
JA
D001506:Beckwith-Wiedemann Syndrome / Q000175:diagnosis*; D001706:Biopsy; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004831:Epilepsies, Myoclonic / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007223:Infant; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis*; D009460:Neurologic Examination; D015835:Ocular Motility Disorders / Q000175:diagnosis*; D010257:Paraneoplastic Syndromes / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed