t(6;12)(q23;q13) and t(10;16)(q22;p11) in a phyllodes tumor of breast.
Cytogenetic analysis of short-term cultures from a phyllodes tumor showed clonal chromosome changes including t(6;12)(q23;q13) and t(10;16)(q22;p11). This is the first reported karyotype in this tumor type. We discuss the breakpoints of these translocations in relation to the involvement of possible candidate genes.
Birdsall
S H
SH
Section of Cell and Experimental Pathology, Institute of Cancer Research, Sutton, Surrey, England.
MacLennan
K A
KA
Gusterson
B A
BA
D000328:Adult; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002879:Chromosomes, Human, Pair 10; D002881:Chromosomes, Human, Pair 12; D002885:Chromosomes, Human, Pair 16; D002896:Chromosomes, Human, Pair 6; D005260:Female; D006801:Humans; D007621:Karyotyping; D003557:Phyllodes Tumor / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic