[The use of MPG in preventing the post-reperfusion injury of an epigastric island flap: an experimental study in rats].
The objective of this work was to study the protective effects of the free radical scavenger N2-mercaptopropionylglycine used in a rat model of reperfusion of epigastric island flaps submitted to transient occlusion of their vascular pedicles. In one group the epigastic vein of the flap was occluded for 5 hours. In the second group the epigastric artery was occluded for 21 hours and in the third group both the epigastric vein and artery were occluded for 8 hours. The scavenger or equivalent volume of saline solution was injected 10 minutes before the vascular occlusion and 10 minutes before declamping. The flap viability was assessed on the seventh day after flap reperfusion. In the three types of vascular occlusion a significant, and differential, increase of the areas of flap survival was observed. The protective effect of N2-mercaptopropionylglycine in reperfusion injuries was demonstrated.
Fontana
C
C
Divisão de Cirurgia, Plástica e Queimaduras, Faculdade de Medicina, Universidade de S. Paulo.
Komatsu
C A
CA
Pigozzi
E
E
Gemperli
R
R
Ferreira
M C
MC
D000818:Animals; D004353:Drug Evaluation, Preclinical; D008297:Male; D008866:Microsurgery / Q000379:methods; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000517:prevention & control*; D013524:Surgical Flaps / Q000379:methods*; D008625:Tiopronin / Q000627:therapeutic use*
D008625:Tiopronin
O uso de MPG na proteção da lesão pósreperfusão do retalho epigástrico em ilha: estudo experimental em rato.