Phospholipids and fatty acids in human brain tumors.
Phospholipid and fatty acid composition of human brain tumors is presented. The white matter contains a greater amount of phosphatidylinositol and a very low level of lysophosphoglycerides, as compared to the grey matter. Glioma and meningioma tumors contain a greater amount of phosphatidylinositol, sphingomyelin, and lysophosphoglycerides, as compared to normal cortex tissue. A significant rise in oleic, linoleic and arachidonic acid content in tumor tissue was observed. It is suggested, that changes in lipid composition, may play a role in structural and functional membrane perturbations in neoplastic cells.
Ledwozyw
A
A
Department of Pathophysiology, Veterinary Faculty of Agricultural Academy, Lublin, Poland.
Lutnicki
K
K
D001932:Brain Neoplasms / Q000378:metabolism*; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D005227:Fatty Acids / Q000378:metabolism*; D005910:Glioma / Q000378:metabolism; D006801:Humans; D008577:Meningeal Neoplasms / Q000378:metabolism; D008579:Meningioma / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*
D005227:Fatty Acids; D010743:Phospholipids