Alterations in carbohydrate metabolism by exogenous dexamethasone and corticosterone in post-hatched White Leghorn chicks.
1. Alterations in carbohydrate metabolism in terms of tissue glycogen contents, phosphorylase (EC 2.4.1.1) activity, hepatic glucose-6-phosphatase (6-6-Pase: EC 3.1.3.9) activity and blood glucose have been evaluated in 30-d-old White Leghorn chicks under induced chronic hypocorticalism (by dexamethasone: DXM) and hypercorticalism (by corticosterone: CORT). 2. DXM treatment showed increased tissue glycogen contents and hypoglycaemia with decreased phosphorylase activity while CORT treatment produced a reverse set of changes. 3. Both steroid treatments increased hepatic G-6-Pase activity. These observations have been taken to indicate a definite role for glucocorticoids in regulating carbohydrate metabolism in neonatal chicks. 4. It is suggested that hypo- or hyper-corticalism could influence carbohydrate metabolism by affecting the secretory/activity ratio of pancreatic hormones.
Joseph
J
J
Department of Zoology, Faculty of Science, M.S. University of Baroda, Vadodara, India.
Ramachandran
A V
AV
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D050260:Carbohydrate Metabolism; D002645:Chickens / Q000378:metabolism*; D003345:Corticosterone / Q000494:pharmacology*; D003907:Dexamethasone / Q000494:pharmacology*; D005952:Glucose-6-Phosphatase / Q000187:drug effects / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D006005:Phosphorylases / Q000187:drug effects / Q000378:metabolism; D013737:Testis / Q000187:drug effects / Q000378:metabolism
D001786:Blood Glucose; D003907:Dexamethasone; D006003:Glycogen; D006005:Phosphorylases; D005952:Glucose-6-Phosphatase; D003345:Corticosterone