title: [2 patients with brain metastases who became pregnant during phenytoin administration].
abstract: Two young women taking phenytoin because of symptomatic brain metastases are described. Both patients, one with end-stage lung cancer and the other in complete remission after intensive chemotherapeutic treatment of a choriocarcinoma, became pregnant while using oral contraceptives in combination with phenytoin. One patient had the child, but died a year after the metastases became apparent, in the other the pregnancy was terminated. When prescribing phenytoin, attention should be paid to fertility--even in patients with end-stage cancer or after intensive, possibly sterilising, chemotherapeutic treatment.
authors.affiliation: Academisch Ziekenhuis, afd. Interne Oncologie, Groningen.
authors.forename: W T
authors.initials: WT
authors.lastname: van der Graaf
authors.forename: A J
authors.initials: AJ
authors.lastname: van Loon
authors.forename: P E
authors.initials: PE
authors.lastname: Postmus
authors.forename: D T
authors.initials: DT
authors.lastname: Sleijfer
mesh_terms: D000032:Abortion, Therapeutic; D000328:Adult; D001932:Brain Neoplasms / Q000556:secondary*; D002289:Carcinoma, Non-Small-Cell Lung / Q000556:secondary*; D002822:Choriocarcinoma / Q000556:secondary*; D003278:Contraceptives, Oral, Hormonal / Q000037:antagonists & inhibitors*; D004336:Drug Antagonism; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D010672:Phenytoin / Q000494:pharmacology* / Q000627:therapeutic use; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic; D014594:Uterine Neoplasms / Q000473:pathology
chemical_list: D003278:Contraceptives, Oral, Hormonal; D010672:Phenytoin
vernacular_title: Twee patiënten met hersenmetastasen die zwanger werden tijdens fenytoïnegebruik.