Functional activity of protein C in newborn infants. A report of a study and a review of the literature.
Protein C is lower in newborn infants than in adults. There are conflicting reports regarding functional activity and the presence of des-gamma carboxylated species in the newborn. We have compared protein C activity and antigenic level in newborn infants and found the activity: antigen ratio to be lower than in adults (0.69 versus 1.0). We discuss this finding in relation to the previously published reports.
Ankola
P
P
Department of Pediatrics, New York University Medical Center, NY 10016.
Nardi
M
M
Karpatkin
M
M
D000328:Adult; D002863:Chromogenic Compounds / Q000378:metabolism; D006801:Humans; D007118:Immunoassay; D007231:Infant, Newborn / Q000097:blood*; D007232:Infant, Newborn, Diseases / Q000097:blood; D011486:Protein C / Q000032:analysis*; D011956:Receptors, Cell Surface / Q000032:analysis; D018179:Receptors, Thrombin
D002863:Chromogenic Compounds; D011486:Protein C; D011956:Receptors, Cell Surface; D018179:Receptors, Thrombin