[An analysis of heritability of intra-erythrocytic Na+, K+ in 139 twins].
By means of the twin model contributions of shared genes and shared environments for red blood cells Na+ and K+ were analysed by genetic and epidemiologic methods. Determination of zygosity was mainly based on examination of red blood cells system, including ABO blood group, MN blood group, P blood group, Rh blood group and secretor status of saliva, such that the probability a dizygotic pair being identical for all of these indices was less than 0.05. 139 pairs of twin in Nan Kai district Tianjin were investigated containing 74 pairs of monozygotic twins (MZ) and 65 pairs of dizygotic twins(DZ). Several methods of estimating genetic heritability (h2) were used, such as the three methods proposed by Vogel, the Holzinger's method. Levine's method based on model of variance analysis and path analysis. The degrees of compatibility of various h2 were also analysed. The contributions of shared genes, shared environments and twin's own special environments were similar for RBC Na+, h2 = 0.32, C2 = 0.35, u2 = 0.33. The contributions of shared environments were the main cause for RBC K+, C2 = 0.97.
Liu
X
X
Department of Epidemiology, Tianjin Medical College.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D004912:Erythrocytes / Q000737:chemistry; D005260:Female; D006801:Humans; D006973:Hypertension / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood*; D012964:Sodium / Q000097:blood*; D000254:Sodium-Potassium-Exchanging ATPase / Q000235:genetics*; D014427:Twins / Q000235:genetics*
D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium