[The effect of carnosine and trolox on cellular chemiluminescence of leukocytes].
The effects of hydrophilic antioxidant carnosine, trolox (6-hydroxy-2.5.7.8-tetramethylchroman-2-carboxylic acid), and superoxide dismutase on the myeloperoxidase activity of leukocytes, superoxide anion and active oxygen species generation have been studied. Physiological concentrations of carnosine have been shown to decrease the ability of human leukocytes to produce chemiluminescence as a result of myeloperoxidase activation. However, the chemiluminescence induced by the generation of the superoxide or its derivatives is unaffected by this process. Trolox does not inhibit the induction of superoxide-dependent chemiluminescence of leukocytes either.
Boldyrev
A A
AA
Department of Clinical Biochemistry, National Research Center, Republic of Cuba.
Stvolinskiĭ
S L
SL
Paskual'
K
K
Romeĭ
Sh
Sh
Del' Kastillo
M D
MD
D000975:Antioxidants / Q000494:pharmacology*; D002336:Carnosine / Q000494:pharmacology*; D002478:Cells, Cultured; D002839:Chromans / Q000494:pharmacology*; D004789:Enzyme Activation; D006801:Humans; D007962:Leukocytes / Q000737:chemistry* / Q000201:enzymology; D008163:Luminescent Measurements; D009195:Peroxidase / Q000378:metabolism
D000975:Antioxidants; D002839:Chromans; D002336:Carnosine; D009195:Peroxidase; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
Vliianie karnozina i troloksa na kletochnuiu khemiliuminestsentsuiu leĭkotsitov.