Enteropathy-associated T-cell lymphoma in a renal transplant patient with evidence of Epstein-Barr virus involvement.
The clinical and histological findings in a 54-year-old patient with enteropathy-associated T-cell lymphoma (EATL) occurring 18 years after renal transplantation are presented. Ten years after adult-onset coeliac disease the patient developed medium to large T-cell non-Hodgkin's lymphoma of the small intestine. Epstein-Barr virus (EBV) genome was detected by polymerase chain reaction in the lymphoma tissue and localized via Epstein-Barr virus RNAs in situ hybridization to some of the tumour cells. This is the first case report of EBV-positive EATL occurring in the setting of immunosuppression.
Borisch
B
B
Institute of Pathology, University of Berne, Switzerland.
Hennig
I
I
Horber
F
F
Bürki
K
K
Laissue
J
J
D001483:Base Sequence; D002051:Burkitt Lymphoma / Q000737:chemistry / Q000150:complications* / Q000473:pathology; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D006801:Humans; D007165:Immunosuppression Therapy; D017403:In Situ Hybridization; D007414:Intestinal Neoplasms / Q000737:chemistry / Q000150:complications* / Q000473:pathology; D007421:Intestine, Small / Q000737:chemistry / Q000382:microbiology / Q000473:pathology; D016030:Kidney Transplantation / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000737:chemistry / Q000150:complications* / Q000473:pathology; D008875:Middle Aged; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics
D004279:DNA, Viral; D012367:RNA, Viral