Cytogenetical observations in two cases of polymorphous low-grade adenocarcinoma of the salivary glands.
The cytogenetical findings in two cases of cultured salivary polymorphous low-grade adenocarcinoma (PLGA) are reported. The first PLGA was a carcinoma ex pleomorphic adenoma of the parotid gland. This had a pseudodiploid stemline characterized by extensive and complicated structural rearrangements. The chromosomal findings showed many similarities to those in the only previously studied case of PLGA (also a carcinoma ex pleomorphic adenoma of the parotid). The results in both could fit with abnormalities superimposed on those typical of mixed tumors. The second PLGA reported derived from a minor salivary gland. It showed a completely different picture, distinguished by a hypodiploid, almost exclusively numerical, variation and the occurrence of a stemline characterized by only monosomy 22. Etiological differences were proposed as one possible explanation for the cytogenetical differences between the two types of PLGA.
Mark
J
J
Department of Pathology and Cytogenetics, Central Hospital, Skövde, Sweden.
Dahlenfors
R
R
Stenman
G
G
Bende
M
M
Melén
I
I
D008949:Adenoma, Pleomorphic / Q000235:genetics* / Q000473:pathology; D000293:Adolescent; D000368:Aged; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008297:Male; D010307:Parotid Neoplasms / Q000235:genetics* / Q000473:pathology; D012468:Salivary Gland Neoplasms / Q000235:genetics* / Q000473:pathology; D012470:Salivary Glands, Minor
D005819:Genetic Markers