Preventive effect of manidipine on severe hypertension and proteinuria induced by the inhibition of endothelial-derived relaxation factor formation in stroke-prone spontaneously hypertensive rats.
The effect of a calcium antagonist, manidipine, on blood pressure and proteinuria induced by the inhibition of endothelial-derived relaxation factor (EDRF) formation was examined. Manidipine attenuated the increase in blood pressure and prevented proteinuria caused by renal damage associated with the inhibition of EDRF formation in stroke-prone spontaneously hypertensive rat (SHRSP) and Wistar Kyoto (WKY) rats.
Nara
Y
Y
Department of Pathology, Shimane Medical University, Izumo, Japan.
Ikeda
K
K
Yamori
Y
Y
D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002561:Cerebrovascular Disorders / Q000209:etiology / Q000378:metabolism*; D004095:Dihydropyridines / Q000627:therapeutic use*; D006973:Hypertension / Q000378:metabolism* / Q000517:prevention & control*; D008297:Male; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D019335:Nitroarginine; D009578:Nitrobenzenes; D010879:Piperazines; D011507:Proteinuria / Q000378:metabolism / Q000517:prevention & control*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D009578:Nitrobenzenes; D010879:Piperazines; D019335:Nitroarginine; D009569:Nitric Oxide; C054218:manidipine; D001120:Arginine