title: In vivo exposure to ultraviolet radiation enhances pathogenic effects of murine leukemia virus, LP-BM5, in murine acquired immunodeficiency syndrome.
abstract: LP-BM5 murine leukemia virus (MuLV) induces an immunodeficiency syndrome (MAIDS) in C57BL/6 mice which resembles immunological abnormalities observed in early stages of human AIDS. In our study, MAIDS virus-infected mice were exposed to low doses of ultraviolet radiation (UVR) before and after virus inoculation and compared with MAIDS-infected but not UVR-exposed mice. In all tested parameters (blood IgM levels; mitogenic responses to PHA, ConA, LPS and anti-mu; MLR; antigenic response to SRBC; enlargement and histopathologic changes of the spleen) we observed the same trend: changes due to MAIDS infection were more pronounced in the UVR-exposed group than in the unexposed group. Statistically significant differences between these two groups were seen for mitogenic responses at two different time points after virus inoculation. These results demonstrate that in vivo UVR exposure enhances the immunosuppressive effects of a retroviral infection. UVR exposure may affect the progression of AIDS in a similar manner.
authors.affiliation: Photomedicine Program, Lovelace Medical Foundation, Albuquerque, NM 87108.
authors.forename: C M
authors.initials: CM
authors.lastname: Brozek
authors.forename: G M
authors.initials: GM
authors.lastname: Shopp
authors.forename: S L
authors.initials: SL
authors.lastname: Ryan
authors.forename: P M
authors.initials: PM
authors.lastname: Gillespie
authors.forename: D F
authors.initials: DF
authors.lastname: Kusewitt
authors.forename: M S
authors.initials: MS
authors.lastname: Rajagopalan
authors.forename: K D
authors.initials: KD
authors.lastname: Ley
authors.forename: R D
authors.initials: RD
authors.lastname: Ley
mesh_terms: D000818:Animals; D005260:Female; D007075:Immunoglobulin M / Q000097:blood; D009052:Leukemia Virus, Murine / Q000472:pathogenicity / Q000528:radiation effects*; D008213:Lymphocyte Activation / Q000528:radiation effects; D008214:Lymphocytes / Q000276:immunology / Q000528:radiation effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D016183:Murine Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D014466:Ultraviolet Rays
chemical_list: D007075:Immunoglobulin M