[Nasopharyngeal carcinoma (NPC) mortality rate in two districts of Guangdong Province and their relation to IgA antibody level against EB virus capsid antigen].
Based upon the retrospective investigation data, the NPC mortality rate in the Pearl River Delta was found to be twice as high as that of Chaoshan district. The positive rate of IgA/VCA antibody in the Pearl River Delta was also found to be significantly higher than that in the Chaoshan district by viro-serological screening. The IgA/VCA antibody positive rate and mortality rate were concomitantly increased with age in the bracket of 30-59. Accordingly, the authors assume that activation of infected EB virus might be an important factor in the process of etiology-pathogenesis of NPC.
Zong
Y S
YS
Shantou University Medical College, Guangdong.
D000328:Adult; D000956:Antigens, Viral / Q000276:immunology*; D002213:Capsid / Q000276:immunology; D036022:Capsid Proteins; D002681:China / Q000453:epidemiology; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000276:immunology / Q000401:mortality*; D012189:Retrospective Studies
D000956:Antigens, Viral; D036022:Capsid Proteins; C041788:Epstein-Barr viral capsid antigen; D007070:Immunoglobulin A