Co-expression of the alpha 1 and beta 2 subunit genes of the GABAA receptor in the magnocellular preoptic nucleus.
Co-localization of the alpha 1 and beta 2 subunit mRNAs of the GABAA receptor was examined on serial sections of the rat magnocellular preoptic nucleus using in situ hybridization histochemistry. More than half of the labeled neurons in this nucleus contained both transcripts, while 31.9% and 17.4% of them contained only alpha 1 or beta 2 subunit mRNA, respectively. These results indicate that there may be three GABAA receptor subtypes in this nucleus, with co-localization of the alpha 1 and beta 2 subunits occurring in the most common subtype.
Zhang
J H
JH
Department of Anatomy and Neuroscience, Osaka University Medical School, Japan.
Sato
M
M
Tohyama
M
M
D000818:Animals; D001345:Autoradiography; D005786:Gene Expression Regulation; D006651:Histocytochemistry; D017403:In Situ Hybridization; D008297:Male; D011301:Preoptic Area / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000096:biosynthesis* / Q000235:genetics
D012333:RNA, Messenger; D011963:Receptors, GABA-A