[The ionic regulation of the receptor binding of S35-tert-butylbicyclophosphorothionate by brain membranes in inbred mice with different emotional stress reactions].
Comparative study of effects of ionic concentrations on [35S]-TBPS binding was performed on brain membranes of inbred mice. It was shown that low concentrations of LiCl (less than 100 mM) were more stimulatory effective in Balb/c (C) mice than in C57Bl/6 (B6) mice. On the contrary, stimulatory activity of NaNO (less than 100 mM) was more pronounced in B6 mice. The revealed line of activity of cations (Li+ > K+ > Na+) and anions (Cl- > or = Br- > I-) makes it possible to doubt interpretation of the obtained data only as affinity of the ions to their channels. We suggest the role of ions as modifiers of surface charge of neuronal membrane, that may be the main cause of the revealed interstrain differences.
Blednov
Iu A
IuA
Nagovitsina
Iu A
IuA
Gordeĭ
M L
ML
Seredenin
S B
SB
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D001643:Bridged Bicyclo Compounds / Q000493:pharmacokinetics*; D019086:Bridged Bicyclo Compounds, Heterocyclic; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D004198:Disease Susceptibility / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D008024:Ligands; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D013045:Species Specificity; D013315:Stress, Psychological / Q000235:genetics / Q000378:metabolism*; D013462:Sulfur Radioisotopes
D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D008024:Ligands; D011956:Receptors, Cell Surface; D013462:Sulfur Radioisotopes; C037476:tert-butylbicyclophosphorothionate
Ionnaia reguliatsiia retseptsii S35-tert-butilbitsiklofosforotionata membranami mozga inbrednykh mysheĭ s razlichnoĭ émotsional'no-stressovoĭ reaktsieĭ.