[The effects of intracoronary injection of nitroglycerin on the coronary circulation: evaluation using a Doppler catheter].
To evaluate the effects of intracoronary injection of nitroglycerin (NTG) on the coronary circulation, we measured the flow velocity of the coronary artery using a Doppler catheter. The Doppler catheter was introduced into the region proximal to the left anterior descending artery (LAD) via an 8F guide catheter positioned at the orifice of the left coronary artery. We measured the flow velocity at a point of 3 mm distal to the catheter tip. One mg (2 ml) of NTG was injected via the 8F guide catheter for 10 sec, followed by injection of 3 ml of normal saline. Then the increasing rate of the diastolic coronary flow velocity in the LAD was calculated. Five ml of iopamidol (dye) was also injected for comparison. The subjects consisted of 14 normal persons (G-N), and 12 patients with angina pectoris accompanying critical stenoses of the LAD, who had no ECG changes or no abnormalities by left ventriculography. The subjects with angina pectoris were subclassified as 90% stenoses (G-A: 5 patients), and 99% stenoses (G-B: 7 patients) in the LAD. 1. After intracoronary injection of NTG, the aortic pressure dropped to various degrees in G-N. In 7 of the normal subjects, who had less than a 20% aortic pressure drop, the increased diastolic flow velocity was more rapid than the control diastolic flow velocity 30 sec after the peak velocity.(ABSTRACT TRUNCATED AT 250 WORDS)
Matsuura
Y
Y
Cardiovascular Division, Osaka National Hospital.
Morioka
T
T
Chin
W
W
Kurihara
T
T
Asao
M
M
Hayashi
T
T
Fukushima
M
M
Imaizumi
M
M
Furukawa
T
T
D000787:Angina Pectoris / Q000503:physiopathology; D001011:Aorta / Q000503:physiopathology; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002404:Catheterization / Q000295:instrumentation; D003326:Coronary Circulation / Q000187:drug effects*; D003331:Coronary Vessels; D006801:Humans; D007269:Injections, Intra-Arterial; D017078:Laser-Doppler Flowmetry / Q000295:instrumentation; D005996:Nitroglycerin / Q000008:administration & dosage / Q000494:pharmacology*
D005996:Nitroglycerin