title: Induction of constitutive heat shock protein 73 mRNA in the dentate gyrus by seizures.
abstract: We examined the effects of generalized seizures on heat shock protein (hsp) mRNA induction in the rat brain using in situ hybridization. Seizures induced by electroconvulsive shock, electrical or cocaine kindling caused a selective induction of the constitutive hsp 73 gene in the dentate gyrus. In these seizure paradigms, not thought to induce widespread tissue damage, neither the heat-inducible hsp 72 gene nor a member of the hsp 90 family (hsp 84) were induced. Hsp 73 may play a role in the adaptation and/or in the maintenance of dentate granule cell integrity following seizures.
authors.affiliation: Clinical Neuroendocrinology Branch, National Institutes of Health, Bethesda, MD 20892.
authors.forename: M L
authors.initials: ML
authors.lastname: Wong
authors.forename: S R
authors.initials: SR
authors.lastname: Weiss
authors.forename: P W
authors.initials: PW
authors.lastname: Gold
authors.forename: S Q
authors.initials: SQ
authors.lastname: Doi
authors.forename: S
authors.initials: S
authors.lastname: Banerjee
authors.forename: J
authors.initials: J
authors.lastname: Licinio
authors.forename: R
authors.initials: R
authors.lastname: Lad
authors.forename: R M
authors.initials: RM
authors.lastname: Post
authors.forename: M A
authors.initials: MA
authors.lastname: Smith
mesh_terms: D000679:Amygdala / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D001345:Autoradiography; D003042:Cocaine / Q000494:pharmacology; D003838:Deoxyadenine Nucleotides; D004597:Electroshock; D005786:Gene Expression Regulation / Q000187:drug effects; D006360:Heat-Shock Proteins / Q000235:genetics*; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D007696:Kindling, Neurologic; D008297:Male; D015345:Oligonucleotide Probes; D012333:RNA, Messenger / Q000096:biosynthesis* / Q000235:genetics; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000503:physiopathology*; D013462:Sulfur Radioisotopes
chemical_list: D003838:Deoxyadenine Nucleotides; D006360:Heat-Shock Proteins; D015345:Oligonucleotide Probes; D012333:RNA, Messenger; D013462:Sulfur Radioisotopes; D003042:Cocaine; C026600:2'-deoxyadenosine triphosphate