[Results and complications of induction treatment of acute leukemia in children. A personal series of 79 cases (1988-1989)].
In 1988 and 1989, 79 children have been treated for induction of acute leukemia. 68 presented an acute lymphoblastic leukemia (ALL) and 11 an acute non-lymphoblastic leukemia (ANLL). The complete remission rate was 92% (96% in ALL, 73% in ANLL). Fever occurred in 50% of the children, with positive blood cultures in 11 of them. One child died from streptococcal sepsis. No metabolic disorder was noted. Four patients were transferred into the intensive care unit. After 8 days, the treatment of ALL was continued in the outpatient clinic in more than 50% of the cases. The treatment of ANLL is frequently complicated by hemorrhages and sepsis and needs adapted supportive care in a specialized unit.
Regaieg
R
R
Service d'hématologie pédiatrique, Hôpital Debrousse, Lyon, France.
Bertrand
Y
Y
Mardini
R
R
Manel
A M
AM
Berthier
J C
JC
Magaud
J P
JP
Charrin
C
C
Barbe
G
G
Souillet
G
G
Philippe
N
N
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001215:Asparaginase / Q000009:adverse effects / Q000627:therapeutic use; D002543:Cerebral Hemorrhage / Q000209:etiology; D017024:Chemotherapy, Adjuvant; D002648:Child; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000188:drug therapy*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000188:drug therapy*; D012074:Remission Induction; D018805:Sepsis / Q000209:etiology; D014178:Translocation, Genetic / Q000187:drug effects
D000305:Adrenal Cortex Hormones; D001215:Asparaginase
Résultats et complications des traitements d'induction des leucémies aiguës de l'enfant. Série personnelle de 79 cas (1988-1989).