[The structural-functional changes in the thymus of the progeny of female rats with experimental chronic cholestasis].
Structural-functional changes to the thymus of progeny of female rats with chronic cholestatic lesions of the liver at different terms of early postnatal ontogeny were investigated. The progeny of this group of animals was found to have less, as compared with controls, mass of the thymus at all periods of the studies, less intensity of the immune reaction of higher sensitivity of the delayed type, less amount of thymocytes of E-RFC. The immunological shifts observed were in close correlation with the morphological alterations in the thymus. The results obtained might be taken as an evidence of the depression of cellular immunity in this group of animals.
Briukhin
G V
GV
Mikhaĭlova
G I
GI
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D002779:Cholestasis / Q000276:immunology / Q000503:physiopathology*; D002908:Chronic Disease; D005260:Female; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D012397:Rosette Formation; D013950:Thymus Gland / Q000276:immunology / Q000503:physiopathology*
Strukturno-funktsional'nye izmeneniia timusa u potomstva samok krys pri éksperimental'nom khronicheskom kholestaze.