Differential pulse voltammetric determination of sumatriptan succinate (1:1) in a tablet dosage form.
A voltammetric study of the oxidation of sumatriptan succinate (1:1) has been carried out at the glassy carbon electrode. This compound exhibited a single wave in Britton-Robinson buffer solutions of pH 2-11, with a maximum current at pH 5.0. The mechanism of oxidation was shown to be due to oxidation of the N-H group in the indole ring. Based on this study, a simple, rapid and sensitive voltammetric method was developed for the determination of the drug in a tablet dosage form.
Sagar
K
K
School of Chemical Sciences, Dublin City University, Ireland.
Fernandez Alvarez
J M
JM
Hua
C
C
Smyth
M R
MR
Munden
R
R
D004563:Electrochemistry; D006863:Hydrogen-Ion Concentration; D007211:Indoles / Q000032:analysis*; D013449:Sulfonamides / Q000032:analysis*; D018170:Sumatriptan; D013607:Tablets; D014662:Vasoconstrictor Agents / Q000032:analysis*
D007211:Indoles; D013449:Sulfonamides; D013607:Tablets; D014662:Vasoconstrictor Agents; D018170:Sumatriptan