Dominant negative mutations in the Wilms tumour (WT1) gene cause Denys-Drash syndrome--proof that a tumour-suppressor gene plays a crucial role in normal genitourinary development.
Hastie
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MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK.
D001483:Base Sequence; D002648:Child; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D005799:Genes, Dominant; D016162:Genes, Wilms Tumor; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics; D008969:Molecular Sequence Data; D013577:Syndrome; D014564:Urogenital Abnormalities; D014566:Urogenital System / Q000254:growth & development; D025721:WT1 Proteins; D009396:Wilms Tumor / Q000235:genetics
D004273:DNA, Neoplasm; D004268:DNA-Binding Proteins; D025721:WT1 Proteins