Possible involvement of myeloperoxidase in lipid peroxidation.
1. Exposure of liposomes to the MPO-H2O2-Cl- system results in oxidation of lipids. Malondialdehyde and 4-hydroxynonenal are formed. 2. Oxidation of liposomes by stimulated rat neutrophils, assessed by malondialdehyde formation, is inhibited by KCN. This indicates involvement of MPO in the process. 3. The MPO-H2O2 system oxidizes mildly LDL but in the presence of chloride a propagation phase, with a rapid increase of conjugated diene formation, was observed.
Stelmaszyńska
T
T
Institute of Biochemistry, University of Graz, Austria.
Kukovetz
E
E
Egger
G
G
Schaur
R J
RJ
D000818:Animals; D006801:Humans; D007700:Kinetics; D015227:Lipid Peroxidation; D010084:Oxidation-Reduction; D009195:Peroxidase / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D013654:Taurine / Q000494:pharmacology; D014364:Tryptophan / Q000494:pharmacology
D010743:Phospholipids; D013654:Taurine; D011189:Potassium Chloride; D014364:Tryptophan; D009195:Peroxidase