title: Ventriculitis and hydrocephalus caused by Candida albicans successfully treated by antimycotic therapy and cerebrospinal fluid shunting.
abstract: A unique case of Candida albicans ventriculitis and hydrocephalus in the absence of any evidence of systemic candidiasis or immunosuppression is reported. Initial treatment with CSF shunting and intravenous antimycotic therapy appeared to have eradicated the infection. Recurrence occurred 5 months after discharge and this was treated by intravenous and intrathecal antimycotic therapy in addition to removal of the shunt system, external ventricular drainage and then replacement of the shunt. A concomitant pyogenic brain abscess responded to burrhole aspiration and antibiotics. The role of mannan antigen monitoring is discussed.
authors.affiliation: Division of Neurosurgery, King Khalid University Hospital, Riyadh, Saudi Arabia.
authors.forename: A
authors.initials: A
authors.lastname: Jamjoom
authors.forename: Z
authors.initials: Z
authors.lastname: al-Abedeen Jamjoom
authors.forename: S
authors.initials: S
authors.lastname: al-Hedaithy
authors.forename: A
authors.initials: A
authors.lastname: Jamali
authors.lastname: Naim-Ur-Rahman
authors.forename: T
authors.initials: T
authors.lastname: Malabarey
mesh_terms: D000293:Adolescent; D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage*; D001922:Brain Abscess / Q000382:microbiology / Q000628:therapy; D002177:Candidiasis / Q000382:microbiology / Q000628:therapy*; D002552:Cerebral Ventricles / Q000382:microbiology*; D002555:Cerebrospinal Fluid / Q000382:microbiology*; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D005260:Female; D005437:Flucytosine / Q000008:administration & dosage*; D006801:Humans; D006849:Hydrocephalus / Q000382:microbiology*; D017964:Itraconazole; D007654:Ketoconazole / Q000008:administration & dosage / Q000031:analogs & derivatives*; D017287:Ventriculoperitoneal Shunt
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B; D005437:Flucytosine; D007654:Ketoconazole