Electrophysiological approaches to the study of bradykinin and nitric oxide in inflammatory pain.
These electrophysiological studies, using desensitization and selective antagonists, demonstrate a peripheral role of bradykinin in the generation of pain in the rat. In addition, nitric oxide is shown to play a complex role in peripheral and spinal events in nociception.
Dickenson
A
A
Dept. of Pharmacology, University College London.
Haley
J
J
Schachter
M
M
Chapman
V
V
D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D001920:Bradykinin / Q000494:pharmacology / Q000502:physiology*; D005557:Formaldehyde; D007249:Inflammation; D019331:NG-Nitroarginine Methyl Ester; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009569:Nitric Oxide / Q000378:metabolism*; D019335:Nitroarginine; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D018002:Receptors, Bradykinin; D017981:Receptors, Neurotransmitter / Q000037:antagonists & inhibitors / Q000502:physiology*; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*
D018002:Receptors, Bradykinin; D017981:Receptors, Neurotransmitter; D005557:Formaldehyde; D019335:Nitroarginine; D009569:Nitric Oxide; D001120:Arginine; D001920:Bradykinin; D019331:NG-Nitroarginine Methyl Ester