[The relationship between bile acid and factors relative to gastric cancer].
By high performance liquid chromatography and 3a-hydroxysteroid dehydrogenase determination, we quantitatively analysed the content of 8 combined biliary acid salt and pH of gastric juice from 35 patients with gastric disease and healthy controls. It was found that both the content of various kinds of biliary acid salt and pH value of gastric juice were much higher in patients with gastric cancer, gastric ulcer, and chronic atrophic gastritis than in normal controls, bile acid salt is known to be harmful to gastric mucosa and that the damage becomes more severe with the increase of bile acid salt concentration and prolongation of exposure, therefore our results suggest that the bile acid salt in the gastric juice is one of the carcinogenic factors.
Xu
M R
MR
Affiliated Hospital, Nantong Medical College, Jiangsu.
D000328:Adult; D000368:Aged; D001647:Bile Acids and Salts / Q000032:analysis*; D005260:Female; D005750:Gastric Juice / Q000737:chemistry*; D005757:Gastritis, Atrophic / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000737:chemistry / Q000209:etiology*; D013276:Stomach Ulcer / Q000378:metabolism
D001647:Bile Acids and Salts