[Serum activity of angiotensin-converting enzyme and osteocalcin levels in hyperthyroidism].
This study was carried out in order to investigate serum changes of osteocalcin (BGP) and angiotensin converting enzyme (SACE) activity in a group of patients with hyperthyroidism. We studied 20 hyperthyroid patients (F 14, M 6; age mean 37.5 +/- 16.8 years) and 13 control subjects (F 11, M 2; age mean 40.3 +/- 7.5 years). In both patients and controls we measured: FT3, FT4, T3, T4, TSH, BGP, SACE. Finally, in patients with hyperthyroidism a TRH test and functional investigations were also performed. We observed that mean SACE levels were significantly increased in hyperthyroid patients (32.06 +/- 10.3 nmol/ml/min) in respect to control subjects (14.66 +/- 3.88 nmol/ml/min) (p = 2.02 E-6). Similarly serum BGP levels were significantly increased in hyperthyroid patients (5.94 +/- 2.55 ng/ml) than in control subjects (2.89 +/- 1.58 ng/ml) (p = 5.66 E-4). There was a significant linear correlation between SACE and T4 levels (r = 0.48; p < 0.05), between serum BGP and T4 (r = 0.50; p < 0.02) and furthermore between SACE and BGP (r = 0.57; p < 0.01). In conclusion both serum BGP and SACE levels are increased in patients with hyperthyroidism and are directly correlated between than and with indexes of thyroid function; therefore, they may be regarded as peripheral indexes of hyperthyroidism.
Letizia
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Istituto di II Clinica Medica, Università degli Studi di Roma La Sapienza.
Minisola
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Cerci
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Tarsitani
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De Ciocchis
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Scavo
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D000328:Adult; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood* / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood*; D007703:Peptidyl-Dipeptidase A / Q000097:blood*; D013960:Thyroid Function Tests; D013963:Thyroid Hormones / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone
D013963:Thyroid Hormones; D015675:Osteocalcin; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D007703:Peptidyl-Dipeptidase A
L'attività sierica dell'enzima di conversione dell'angiotensina ed i livelli di osteocalcina nell'ipertiroidismo.