Alpha-adrenergic bronchoprovocation in neonates with bronchopulmonary dysplasia.
Ophthalmic administration of phenylephrine caused decreased pulmonary compliance, tidal volume, and peak airflow values in infants with bronchopulmonary dysplasia but not in control infants. The alpha-adrenergic effects of phenylephrine may aggravate the bronchospastic component of bronchopulmonary dysplasia.
Mirmanesh
S J
SJ
Section on Newborn Pediatrics, Pennsylvania Hospital.
Abbasi
S
S
Bhutani
V K
VK
D016535:Bronchial Hyperreactivity; D001985:Bronchial Provocation Tests; D001997:Bronchopulmonary Dysplasia / Q000503:physiopathology*; D016022:Case-Control Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009883:Ophthalmic Solutions; D010656:Phenylephrine / Q000008:administration & dosage / Q000494:pharmacology*; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D015656:Respiratory Mechanics / Q000187:drug effects*
D009883:Ophthalmic Solutions; D011942:Receptors, Adrenergic, alpha; D010656:Phenylephrine