Long-term treatment with sodium cromoglycate, nedocromil sodium and beclomethasone dipropionate reduces bronchial hyperresponsiveness in asthmatic subjects.
165 patients (106 males, 59 females) entered an open group comparative study of a 12-week test treatment on bronchial hyperresponsiveness (BHR) determined by methacholine challenge. Patients were randomly allocated to receive nedocromil sodium (4 mg q.i.d.), sodium cromoglycate (10 micrograms q.i.d.) and beclomethasone dipropionate (500 micrograms t.i.d.). At the end of the study, an 2.25-fold increase of the PD20FEV1 was noted in all the treated patients. No significant difference was noted among the treatments.
Orefice
U
U
Respiratory Physiopathology Department, Civil Hospital of Udine, Italy.
Struzzo
P
P
Dorigo
R
R
Peratoner
A
A
D000328:Adult; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology*; D001507:Beclomethasone / Q000627:therapeutic use; D016535:Bronchial Hyperreactivity / Q000188:drug therapy* / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D001993:Bronchodilator Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D004205:Cromolyn Sodium / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D017835:Nedocromil; D015363:Quinolones / Q000627:therapeutic use
D001993:Bronchodilator Agents; D015363:Quinolones; D017835:Nedocromil; D001507:Beclomethasone; D004205:Cromolyn Sodium