The effect of insulin on glucose and protein metabolism in the forearm of cancer patients.
This study was designed to study the effect of systemic hyperinsulinaemia (INS) on glucose and protein metabolism in cancer patients. Sixteen cancer patients (8 > 10% weight loss (WL); 8 < 10% weight loss (NWL)) were compared with 12 healthy controls. Glucose uptake (GU) and phenylalanine (PHE) exchange kinetics were measured across the forearm in the postabsorptive state (PA) and in response to INS (71 +/- 5 microU ml-1). At steady state in response to INS, the negative PA PHE net balance became significantly positive, and GU significantly increased, for cancer and control groups, with no significant differences between the two groups. Subset analysis of NWL cancer vs. WL cancer found no difference between WL and NWL for the change in PHE balance from PA and INS, however GU increased significantly only for the NWL group between PA and INS. These data indicate that cancer patients are not resistant to the anabolic effect of INS on protein metabolism, regardless of weight loss, but are resistant to the effect of INS on glucose metabolism when further along in the disease process as evident by more significant weight loss. This differential response to the effect of INS can be exploited in an attempt to promote protein accrual in weight-losing cancer patients.
Newman
E
E
Surgical Metabolism Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10021.
Heslin
M J
MJ
Wolf
R F
RF
Pisters
P W
PW
Brennan
M F
MF
D000368:Aged; D000596:Amino Acids / Q000097:blood / Q000187:drug effects; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects / Q000378:metabolism*; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood* / Q000188:drug therapy; D004341:Drug Evaluation; D005260:Female; D005542:Forearm / Q000502:physiology*; D005770:Gastrointestinal Neoplasms / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood; D007328:Insulin / Q000008:administration & dosage*; D007333:Insulin Resistance; D008175:Lung Neoplasms / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009124:Muscle Proteins / Q000097:blood* / Q000187:drug effects; D015431:Weight Loss / Q000187:drug effects
D000596:Amino Acids; D001786:Blood Glucose; D007328:Insulin; D009124:Muscle Proteins