From genes to complex structures of bluetongue virus and their efficacy as vaccines.
Bluetongue virus-like and core-like structures consisting of multiproteins in different molar ratios, have been synthesized using baculovirus multiple expression vectors. These particles lacking genetic materials, mimic the single- and double-shelled authentic virus particles and have been shown to be highly immunogenic and protective for sheep challenged with infectious virus. The formation of virus-like particles, using this new technology, offers a novel approach to vaccine development.
Roy
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Laboratory of Molecular Biophysics, Oxford University, UK.
D000818:Animals; D016367:Baculoviridae / Q000235:genetics; D001819:Bluetongue / Q000517:prevention & control*; D001820:Bluetongue virus / Q000235:genetics* / Q000276:immunology / Q000648:ultrastructure; D004279:DNA, Viral / Q000235:genetics; D015967:Gene Expression Regulation, Viral; D005822:Genetic Vectors; D008854:Microscopy, Electron; D012756:Sheep; D014611:Vaccination / Q000662:veterinary; D014614:Vaccines, Synthetic; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology; D014765:Viral Vaccines; D014766:Viremia / Q000517:prevention & control / Q000662:veterinary; D014771:Virion / Q000235:genetics* / Q000276:immunology / Q000648:ultrastructure
D004279:DNA, Viral; D014614:Vaccines, Synthetic; D014764:Viral Proteins; D014765:Viral Vaccines