Sympathetic nervous system modulates macrophage function.
We have reported previously that sympathectomy augments immune responses in mice and rats. In the present study, we show that ablation of the sympathetic nervous system augments macrophage function as measured by increased TNF secretion. We also show that a factor present in the sympathetic ganglia of newborn rats, suppresses secretion of TNF by LPS-stimulated macrophages as does the beta-adrenergic agonist isoproterenol.
Chelmicka-Schorr
E
E
Department of Neurology, Brain Research Institute, University of Chicago, IL 60637.
Kwasniewski
M N
MN
Czlonkowska
A
A
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002478:Cells, Cultured; D005728:Ganglia, Sympathetic / Q000502:physiology; D007545:Isoproterenol / Q000494:pharmacology; D008264:Macrophages / Q000502:physiology*; D051379:Mice; D008808:Mice, Inbred CBA; D013564:Sympathetic Nervous System / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D014409:Tumor Necrosis Factor-alpha; D003994:Bucladesine; D007545:Isoproterenol