Serotonin-stimulated phosphoinositide hydrolysis in platelets from post-withdrawal alcoholics.
It has previously been reported that serotonin-stimulated second messenger formation is inhibited in platelets from alcoholics undergoing detoxification. Serotonin-stimulated signal transduction was therefore analysed in platelets from young post-withdrawal alcoholics to elucidate whether the previously reported inhibition is a state or trait marker of alcoholism. No difference between post-withdrawal alcoholics and controls was found with regard to serotonin-stimulated [32P]-phosphatidylinositol 4,5-bisphosphate hydrolysis or [32P]-phosphatidic acid formation. The results indicate that the inhibited serotonin2 receptor function seen in alcoholics undergoing detoxification is a state-dependent rather than a trait-dependent marker.
Simonsson
P
P
Department of Psychiatry, Lund University, Sweden.
Berglund
M
M
Oreland
L
L
Moberg
A L
AL
Alling
C
C
D000328:Adult; D000437:Alcoholism / Q000097:blood*; D001792:Blood Platelets / Q000187:drug effects; D000431:Ethanol / Q000009:adverse effects; D006801:Humans; D006868:Hydrolysis; D008297:Male; D010716:Phosphatidylinositols / Q000096:biosynthesis*; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000097:blood*
D010716:Phosphatidylinositols; D011985:Receptors, Serotonin; D012701:Serotonin; D000431:Ethanol