Effects of platelet activating factor on cyclic AMP accumulation in human lymphocytes.
The in vitro effects of platelet activating factor (PAF) on intracellular adenosine 3',5'-cyclic adenosine monophosphate (cAMP) accumulation were assessed in human lymphocytes in ten healthy volunteers and in eight asthmatic patients. Platelet activating factor to increased intracellular cAMP in both groups. In addition, PAF also enhanced the effects of isoproterenol and theophylline on intracellular cAMP production in these two groups.
Wang
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Allergic Disease Center, School of Medicine, Creighton University, Omaha, Nebraska.
Townley
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RG
D000328:Adult; D000704:Analysis of Variance; D001249:Asthma / Q000378:metabolism; D000242:Cyclic AMP / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010972:Platelet Activating Factor / Q000494:pharmacology*; D013806:Theophylline / Q000494:pharmacology
D010972:Platelet Activating Factor; D013806:Theophylline; D000242:Cyclic AMP; D007545:Isoproterenol