Inositol lipids in cell signalling.
In the past year, major advances have been made in our understanding of the regulation of phosphoinositidase C, and of the action of the inositol trisphosphate receptor and how it may generate 'quantal' Ca2+ release. The functions of inositol tetrakisphosphate and of the 3-phosphorylated inositol lipids continue to generate controversy, but both may be well on the way towards some clarification. Finally, we may have to extend our concept of the inositide cycle to include an intranuclear signalling function.
Irvine
R F
RF
AFRC Institute of Animal Physiology and Genetics Research, Cambridge, UK.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels; D006801:Humans; D053496:Inositol 1,4,5-Trisphosphate Receptors; D007295:Inositol Phosphates / Q000378:metabolism*; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear; D015290:Second Messenger Systems; D015398:Signal Transduction
D015220:Calcium Channels; C506926:ITPR1 protein, human; D053496:Inositol 1,4,5-Trisphosphate Receptors; D007295:Inositol Phosphates; D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; D010727:Phosphoric Diester Hydrolases; C021491:glycerophosphoinositol glycerophosphodiesterase; D002118:Calcium