[Regional therapy to prevent recurrence after surgery in hepatocellular carcinoma].
The significance of regional therapy to prevent recurrence after surgery for hepatocellular carcinoma (HCC) was evaluated. In 275 patients who underwent hepatic resection for HCC, 143 (52%) had recurrences. Post-recurrence survival of the patients with regional therapy for recurrent foci was significantly better than that of patients without such therapy. Five-year post-recurrence survival of the patients treated with second surgery (77%) was significantly better than that of patients treated with chemoembolization (17%). The difference in 5-year survival between the former and the latter seemed to be caused by the difference in the degree of tumor progression at the recurrence. A second hepatic resection was the treatment of choice for a solitary intrahepatic recurrent tumor. However, chemoembolization was recommended for two or more recurrent foci.
Sasaki
Y
Y
Dept. of Surgery, Center for Adult Diseases, Osaka.
Imaoka
S
S
Masutani
S
S
Ohashi
I
I
Iwamoto
S
S
Nakamori
S
S
Ohigashi
H
H
Kameyama
M
M
Hiratsuka
M
M
Ishikawa
O
O
D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000601:surgery / Q000628:therapy*; D004621:Embolization, Therapeutic; D006498:Hepatectomy; D006499:Hepatic Artery; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000601:surgery / Q000628:therapy*; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D015996:Survival Rate