title: [The vagotropic action of peptides isolated from the brain of hibernating susliks].
abstract: Dipeptide ASP-TYR extracted from the brain of hibernating squirrels was found to potentiate vagal effect on the cardiac rhythm, whereas pentapeptide neokyotorphin--to diminish it. In both cases the effect was due to an alteration of the tonic component's strength in the vagal chronotropic effect. The selective peptidergic modulation of the vagal effect on the cardiac rhythm suggests different physiological roles of the tonic and synchronizing components in regulation of the heart.
authors.forename: V M
authors.initials: VM
authors.lastname: Pokrovskiĭ
authors.forename: O E
authors.initials: OE
authors.lastname: Osadchiĭ
authors.forename: Iu R
authors.initials: IuR
authors.lastname: Sheĭkh-zade
authors.forename: V I
authors.initials: VI
authors.lastname: Sviriaev
authors.forename: B V
authors.initials: BV
authors.lastname: Vas'kovskiĭ
authors.forename: R Kh
authors.initials: RKh
authors.lastname: Ziganshin
authors.forename: I I
authors.initials: II
authors.lastname: Mikhaleva
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D002415:Cats; D004151:Dipeptides / Q000302:isolation & purification / Q000494:pharmacology*; D004558:Electric Stimulation; D004562:Electrocardiography / Q000187:drug effects; D004723:Endorphins / Q000302:isolation & purification / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006605:Hibernation / Q000502:physiology*; D012589:Sciuridae / Q000502:physiology*; D013997:Time Factors; D014630:Vagus Nerve / Q000187:drug effects* / Q000502:physiology
chemical_list: D004151:Dipeptides; D004723:Endorphins; C078779:aspartyltyrosine; C036450:neo-kyotorphin
vernacular_title: Vagotropnoe deĭstvie peptidov, vydelennykh iz mozga giberniruiushchikh suslikov.