[Genetic correlation between the arterial pressure response during emotional stress and the alpha1-adrenoreceptor concentration in brain regions].
Arterial blood pressure reactivity to the emotional stress and brain alpha 1-adrenoreceptors concentrations were studied in hypertensive (ISIAH strain) and normotensive (Wistar strain) rats and their F1 and F2 hybrids. Significant correlations between the stress-induced increase in the arterial blood pressure and the amount of alpha 1-adrenoreceptors in hypothalamus (+0.46) and medulla (+0.38) were found in the F2. This cosegregation may point to the significant role of genetically determined peculiarities of expression of alpha 1-adrenoreceptors in brain regions during pathogenesis of arterial hypertension in the ISIAH strain.
Markel'
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AL
Shishkina
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GT
D000818:Animals; D001794:Blood Pressure / Q000235:genetics*; D006973:Hypertension / Q000235:genetics*; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D008526:Medulla Oblongata / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D011942:Receptors, Adrenergic, alpha / Q000235:genetics* / Q000378:metabolism; D013315:Stress, Psychological / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*
D011942:Receptors, Adrenergic, alpha
Geneticheskaia korreliatsiia reaktsii arterial'nogo davleniia pri émotsional'nom stresse s kontsentratsieĭ alpha1-adrenoretseptorov v otdelakh mozga.