Renal venous erythropoietin concentrations in hypertensive patients with unilateral renal disease.
In 24 hypertensive patients with unilateral renal disease, the erythropoietin (Epo) concentration ratio in the renal veins was compared with the renin ratio. Seven patients showed moderately elevated peripheral Epo values. Epo and plasma renin activity were significantly positively correlated both in peripheral and renal veins. This suggests that the reduction of renal blood flow was a common, but not unique, stimulating factor of Epo and renin secretion. Epo ratio appeared insensitive since it was greater than 1.5 in only 30% of patients with a renin ratio > 2. Our results indicate that the Epo concentration ratio in renal veins cannot be proposed as a substitute for the currently used renin ratio.
Labeeuw
M
M
Department of Nephrology, E. Herriot Hospital, Lyon, France.
Prost
N F
NF
Daoud
S
S
Lapra
C
C
Zech
P
P
Pozet
N
N
D000293:Adolescent; D000328:Adult; D000368:Aged; D001794:Blood Pressure; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D006801:Humans; D006977:Hypertension, Renal / Q000097:blood* / Q000503:physiopathology / Q000601:surgery; D006978:Hypertension, Renovascular / Q000097:blood / Q000503:physiopathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012082:Renal Veins; D012083:Renin / Q000097:blood
D004921:Erythropoietin; D012083:Renin