title: [The proton MR spectroscopy of intracranial tumors. The differential diagnostic aspects for gliomas, metastases and meningiomas].
abstract: Twenty-two patients with intracranial tumours were examined by MR images and in vivo proton-MR-spectroscopy. The changes of relative concentrations of NAA, PCr/Cr, Cho, and Ins were measured spectroscopically and the amount of these metabolites were related to different tumour groups. Analysis of the results has shown that the spectra from all the tumours differed from normal spectra. All cerebral tumours showed marked reduction of the Pcr/Cho quotient and the NAA/Cho quotient was also reduced. The Ins/Cho quotient for meningiomas and metastases was also lower than in normals; in gliomas of low malignancy the quotient was slightly raised and in gliomas of greater malignancy it was significantly higher than normal. The spectra of cerebral metastases showed unusual high lipid signals of 0.9 ppm and 1.25 ppm. The only common feature for meningiomas was marked reduction of NAA concentration. In summary, localised in vivo proton-MR-spectroscopy can be used clinically to obtain valuable information for the differential diagnosis of gliomas and intracerebral metastases.
authors.affiliation: Radiologische Klinik Innenstadt, Universität München.
authors.forename: T J
authors.initials: TJ
authors.lastname: Vogl
authors.forename: A
authors.initials: A
authors.lastname: Jassoy
authors.forename: O
authors.initials: O
authors.lastname: Söllner
authors.forename: C
authors.initials: C
authors.lastname: Becker
authors.forename: C
authors.initials: C
authors.lastname: Hamburger
authors.forename: A
authors.initials: A
authors.lastname: Dadashi
authors.forename: R
authors.initials: R
authors.lastname: Sauter
authors.forename: J
authors.initials: J
authors.lastname: Lissner
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D003937:Diagnosis, Differential; D005069:Evaluation Studies as Topic; D005910:Glioma / Q000175:diagnosis*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods; D008577:Meningeal Neoplasms / Q000175:diagnosis*; D008579:Meningioma / Q000175:diagnosis*; D011522:Protons; D011786:Quality Control
chemical_list: D011522:Protons
vernacular_title: Protonen-MR-Spektroskopie intrakranieller Tumoren. Differentialdiagnostische Aspekte für Gliome, Metastasen und Meningeome.