title: Heat shock treatment of macrophages causes increased release of superoxide anion.
abstract: Heat shock treatment of murine macrophages and the J774 cell line resulted in an enhanced capacity to release superoxide anion (O2-) upon stimulation. There was no concomitant increase in hydrogen peroxide production, and the macrophage microbicidal activity against Mycobacterium tuberculosis, Mycobacterium avium complex, and Staphylococcus aureus was not altered.
authors.affiliation: Section of Infectious Diseases, University of Illinois College of Medicine, Chicago.
authors.forename: M V
authors.initials: MV
authors.lastname: Reddy
authors.forename: P R
authors.initials: PR
authors.lastname: Gangadharam
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D006358:Hot Temperature; D006861:Hydrogen Peroxide / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D009169:Mycobacterium tuberculosis / Q000276:immunology; D010587:Phagocytosis; D013481:Superoxides / Q000378:metabolism*
chemical_list: D013481:Superoxides; D006861:Hydrogen Peroxide