[Effects of GABA antagonist-induced seizures on 3H-muscimol and 3H-diazepam binding in the rat striatum].
The binding of 3H-muscimol and 3H-diazepam to rat striatum membranes after picrotoxin- and bicuculline-induced seizures was characterized. No alteration in the maximal binding capacity (Bmax) of 3H-muscimol was observed. However, bicuculline produced a 27% decrease in Kd. Both picrotoxin and bicuculline increased the binding capacity of 3H-diazepam. Bicuculline produced a 86% increase in Kd. These results suggest that the GABA antagonists-induced seizures may modulate 3H-muscimol and 3H-diazepam binding in rat striatum.
Sofronov
G A
GA
Golovko
A I
AI
D000818:Animals; D001640:Bicuculline; D001665:Binding Sites; D003342:Corpus Striatum / Q000378:metabolism*; D003975:Diazepam / Q000378:metabolism*; D018756:GABA Antagonists; D008297:Male; D009118:Muscimol / Q000378:metabolism*; D010852:Picrotoxin; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism*; D014316:Tritium
D001640:Bicuculline; D003975:Diazepam; D018756:GABA Antagonists; D009118:Muscimol; D010852:Picrotoxin; D011963:Receptors, GABA-A; D014316:Tritium
Vliianie sudorog, vyzvannykh GAMK-litikami, na sviazyvanie 3H-mustsimola i 3H-diazepama v striatume krys.