title: [Primary dexamethasone-suppressible hyperaldosteronism and hyperprolactinemia].
abstract: This report describes a clinical case with rare association: dexamethasone-suppressible hyperaldosteronism (DSH) and hyperprolactinemia. Previous studies reported that endogenous dopaminergic activity would be increased in both primary aldosteronism and in hyperprolactinemic syndromes. By manipulating dopamine tone with metoclopramide, bromocriptine, ACTH and amineptine, the aldosterone and prolactin responsiveness was evaluated. Our results showed a lack of dopamine inhibiting aldosterone secretion, despite dopaminergic tone is known to be increased in hyperprolactinemia. Thus it seems unlikely that dopaminergic control of aldosterone secretion could be account for this type of hyperaldosteronism associated to hyperprolactinemia, where the suggestion is that ACTH represents the principal regulator of aldosterone secretion.
authors.affiliation: Cattedra di Medicina Interna, Università degli Studi, Torino.
authors.forename: F
authors.initials: F
authors.lastname: Veglio
authors.forename: G
authors.initials: G
authors.lastname: Pinna
authors.forename: F
authors.initials: F
authors.lastname: Rabbia
authors.forename: P
authors.initials: P
authors.lastname: Mulatero
authors.forename: L
authors.initials: L
authors.lastname: Chiandussi
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000494:pharmacology / Q000502:physiology; D000328:Adult; D000450:Aldosterone / Q000378:metabolism; D001971:Bromocriptine / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology / Q000627:therapeutic use*; D003986:Dibenzocycloheptenes / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology / Q000502:physiology; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D006966:Hyperprolactinemia / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D008787:Metoclopramide / Q000494:pharmacology; D011388:Prolactin / Q000378:metabolism; D012636:Secretory Rate / Q000187:drug effects
chemical_list: D003986:Dibenzocycloheptenes; C011597:amineptin; D001971:Bromocriptine; D000450:Aldosterone; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D008787:Metoclopramide; D004298:Dopamine
vernacular_title: Iperaldosteronismo primitivo desametazone-soppressibile (DSH) ed iperprolattinemia.