[Pseudomonas aeruginosa and beta-lactam resistance phenotypes (Tunisia 1989-1990)].
366 strains of P. aeruginosa were studied. More than half of samples were issued from urology (40%) and general surgery (21%) and samples are mostly urine specimens (46%). The phenotypes of resistance to 3 beta-lactams (respectively ticarcillin, cefotaxime and ceftazidime) showed that 73% of the strains were wild phenotype (SSS-SIS-SRS). The MIC of ticarcillin +/- clavulanic acid, azlocillin, cefoperazone, cefsulodin, cefotaxime and ceftazidime against 93 strains chosen among different phenotypes of resistance showed that ceftazidime is the most active beta-lactam, 93% of strains being inhibited by 16 micrograms/ml. These MIC and iodometric test performed on 33 strains with ticarcillin MIC > 128 mg/l showed that acquired resistance was non enzymatic in 21% of cases and was related to beta-lactamase production in 79% of cases.
Kamoun
A
A
Laboratoire de Microbiologie, Hôpital Charles Nicolle, Tunis.
Ben Hassen
A
A
Fendri
C
C
Ben Redjeb
S
S
D002439:Cefotaxime; D002442:Ceftazidime; D002510:Cephalosporinase / Q000378:metabolism; D004352:Drug Resistance, Microbial; D006801:Humans; D008826:Microbial Sensitivity Tests; D010405:Penicillinase / Q000378:metabolism; D010641:Phenotype; D011159:Population Surveillance; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000145:classification / Q000235:genetics*; D012703:Serotyping; D013982:Ticarcillin; D014416:Tunisia / Q000453:epidemiology; D001618:beta-Lactamases / Q000378:metabolism
D002442:Ceftazidime; D002510:Cephalosporinase; D010405:Penicillinase; D001618:beta-Lactamases; D013982:Ticarcillin; D002439:Cefotaxime
Pseudomonas aeruginosa et phénotypes de résistance aux beta-lactamines (Tunis, 1989-1990).