Proofreading, NTPases and translation: successful increase in specificity.
The discussion of proofreading started in the April issue of TIBS is completed by treating the two branched Michaelis-Menten enzymes that can proofread. The conditions required for proofreading can be seen to determine the expression of proofreading in its biological settings. There are surely instances of proofreading as yet unrecognized.
Yarus
M
M
Department of MCD Biology, University of Colorado, Boulder 80309-0347.
D007700:Kinetics; D043583:Nucleoside-Triphosphatase; D010744:Phosphoric Monoester Hydrolases / Q000502:physiology*; D014176:Protein Biosynthesis / Q000502:physiology*; D013379:Substrate Specificity
D010744:Phosphoric Monoester Hydrolases; D043583:Nucleoside-Triphosphatase