title: Polylactide and polyglycolic acid-reinforced coralline hydroxy-apatite for the reconstruction of cranial bone defects in the rabbit.
abstract: The possibility of using coralline hydroxy-apatite in combination with polylactide and polyglcycolic acid instead of a bone graft in the skull region is examinated. Coralline hydroxy-apatite blocks strengthened with a membrane made of a combination of polylactide and polyglycolic acid were inserted into bony defects created in 12 rabbit skulls. The blocks were observed during a follow-up of 12 months. They became fixed to the surrounding bone and no adverse effects or harmful reactions in the nearby tissues could be detected.
authors.affiliation: Department of Surgery, Oulu University Central Hospital, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Antikainen
authors.forename: M
authors.initials: M
authors.lastname: Ruuskanen
authors.forename: R
authors.initials: R
authors.lastname: Taurio
authors.forename: M
authors.initials: M
authors.lastname: Kallioinen
authors.forename: W
authors.initials: W
authors.lastname: Serlo
authors.forename: P
authors.initials: P
authors.lastname: Törmälä
authors.forename: T
authors.initials: T
authors.lastname: Waris
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D017886:Durapatite; D005549:Foreign-Body Reaction / Q000473:pathology; D006882:Hydroxyapatites; D016348:Osseointegration / Q000502:physiology; D011091:Polyesters; D011100:Polyglycolic Acid; D019736:Prostheses and Implants; D011817:Rabbits; D012886:Skull / Q000473:pathology / Q000601:surgery*; D014945:Wound Healing / Q000502:physiology
chemical_list: D001672:Biocompatible Materials; D006882:Hydroxyapatites; D011091:Polyesters; D011100:Polyglycolic Acid; C033616:poly(lactide); D017886:Durapatite