[The biochemical aspects of the stimulating action of exogenous RNAse].
A sequence of biochemical reactions in yeast from moment of RNAse interaction with cell membrane to cell division has been studied. RNAse addition in growth medium causes the increase of Ca2+ entering rate in cells in 2.4 times. Under this condition the increase of membrane enzyme adenylate cyclase correlating with the growth of cAMP content in cell and rise of cAMP-dependent protein kinase activity have been observed. A hypothetic scheme of cellular response on the RNAse effect is suggested.
Kolpakov
A I
AI
Kupriianova-Ashina
F G
FG
D000262:Adenylyl Cyclases / Q000187:drug effects / Q000502:physiology; D001407:Bacillus / Q000201:enzymology; D002118:Calcium / Q000378:metabolism; D002175:Candida / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D000242:Cyclic AMP / Q000502:physiology; D004722:Endoribonucleases / Q000494:pharmacology; D011494:Protein Kinases / Q000187:drug effects / Q000502:physiology; D012260:Ribonucleases / Q000494:pharmacology*; D015290:Second Messenger Systems / Q000187:drug effects; D013268:Stimulation, Chemical; D013997:Time Factors
D000242:Cyclic AMP; D011494:Protein Kinases; D004722:Endoribonucleases; D012260:Ribonucleases; C022543:ribonuclease T(2); D000262:Adenylyl Cyclases; D002118:Calcium
Biokhimicheskie aspekty stimuliruiushchego deĭstviia ékzogennykh RNKaz.