L-baclofen-sensitive GABAB binding sites in the medial vestibular nucleus localized by immunocytochemistry.
L-Baclofen-sensitive GABAB binding sites in the medial vestibular nucleus (MVN) were identified immunocytochemically and visualized ultrastructurally in L-baclofen-preinjected rats and monkeys, using a mouse monoclonal antibody with specificity for the p-chlorophenyl moiety of baclofen. Saline-preinjected animals showed no immunostain. In drug-injected animals, there was evidence for both pre- and postsynaptic GABAergic inhibition in MVN mediated by GABAB receptors. These neural elements could be utilized in control of velocity storage in the vestibulo-ocular reflex.
Holstein
G R
GR
Department of Neurology, Mount Sinai School of Medicine, New York 10029.
Martinelli
G P
GP
Cohen
B
B
D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D000882:Haplorhini; D007124:Immunoenzyme Techniques; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects*; D014726:Vestibular Nuclei / Q000737:chemistry / Q000187:drug effects*
D011963:Receptors, GABA-A; D001418:Baclofen