Drosophila retinal degeneration C (rdgC) encodes a novel serine/threonine protein phosphatase.
The Drosophila retinal degeneration C (rdgC) gene is required to prevent light-induced retinal degeneration. Molecular analysis shows that the rdgC transcription unit encodes a novel serine/threonine protein phosphatase. Amino acids 153-393 define a domain that has 30% identity with the catalytic domains of types 1, 2A, and 2B serine/threonine protein phosphatases. A putative regulatory domain is appended that contains multiple potential Ca(2+)-binding sites or "EF hand motifs." Thus, the analysis suggests that the rdgC protein is a novel type of serine/threonine protein phosphatase that is directly regulated by Ca2+. rdgC is expressed in the visual systems of the fly, as well as in the mushroom bodies of the central brain.
Steele
F R
FR
Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892.
Washburn
T
T
Rieger
R
R
O'Tousa
J E
JE
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002135:Calcium-Binding Proteins; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D004252:DNA Mutational Analysis; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics*; D005796:Genes; D008969:Molecular Sequence Data; D010749:Phosphoprotein Phosphatases / Q000235:genetics* / Q000378:metabolism; D011487:Protein Conformation; D015183:Restriction Mapping; D012162:Retinal Degeneration / Q000235:genetics*; D016415:Sequence Alignment; D014018:Tissue Distribution
D002135:Calcium-Binding Proteins; D029721:Drosophila Proteins; D010749:Phosphoprotein Phosphatases; C074643:rdgC protein, Drosophila