Tissue kallikrein-kinin system in the brain and the regulation of arterial pressure.
The intracerebral administration of kininase inhibitors produced an increase in arterial pressure of the SHR but not in normotensive animals. The SHR were several fold more sensitive to the pressor response elicited by the intracerebral injection of bradykinin, however SHR with low blood pressure showed decreased sensitivity to the bradykinin pressor effect. The results suggest that an endogenous kinin system plays a role in the central regulation of blood pressure of the SHR.
Fior
D R
DR
Department of Biophysics, Escola Paulista de Medicina, São Paulo, SP, Brazil.
Martins
D T
DT
Lindsey
C J
CJ
D010129:4-Aminobenzoic Acid / Q000008:administration & dosage / Q000494:pharmacology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001920:Bradykinin / Q000008:administration & dosage / Q000494:pharmacology*; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D015773:Enalaprilat / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007276:Injections, Intraventricular; D009842:Oligopeptides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D017208:Rats, Wistar; D062366:para-Aminobenzoates
D000806:Angiotensin-Converting Enzyme Inhibitors; D009842:Oligopeptides; D062366:para-Aminobenzoates; C053306:N-(1-carboxy-2-phenylethyl)-alanyl-alanyl-phenylalanine-4-aminobenzoate; D015773:Enalaprilat; D001920:Bradykinin; D010129:4-Aminobenzoic Acid