title: Dietary selenate versus selenite for cattle, sheep, and horses.
abstract: Food and Drug Administration regulations currently permit addition of .3 mg of Se per kilogram of diet for chickens, turkeys, ducks, swine, sheep, and cattle. However, field reports indicate that this level may not be adequate for ruminants in all situations. Because sodium selenite is the most common supplemental form and is known to be readily absorbed to particles or reduced to insoluble elemental Se or selenides in acid, anaerobic environments, studies were conducted with dairy cattle, sheep, and horses fed sodium selenate to determine whether Se from this source was more bioavailable than Se from sodium selenite. A 2-wk period of no Se supplementation was followed by 49 or 56 d of Se supplementation at .3 mg/kg of dietary DM. Serum Se concentrations and glutathione peroxidase (GSHPx) activities measured initially and periodically thereafter revealed no difference between Se forms in sheep and horses and only a small (P less than .05) advantage for selenate in supporting serum Se concentration in dairy cattle. Selenium concentrations in skeletal muscle and liver of sheep were not different between Se forms. Serum Se, but not GSHPx, increased with time, and .3 mg of supplemental Se per kilogram of dietary DM from either sodium selenate or sodium selenite supported normal serum Se concentrations in sheep, dairy cattle, and horses.
authors.affiliation: Department of Animal Science, Michigan State University, East Lansing 48824.
authors.forename: K L
authors.initials: KL
authors.lastname: Podoll
authors.forename: J B
authors.initials: JB
authors.lastname: Bernard
authors.forename: D E
authors.initials: DE
authors.lastname: Ullrey
authors.forename: S R
authors.initials: SR
authors.lastname: DeBar
authors.forename: P K
authors.initials: PK
authors.lastname: Ku
authors.forename: W T
authors.initials: WT
authors.lastname: Magee
mesh_terms: D000818:Animals; D001682:Biological Availability; D002417:Cattle / Q000378:metabolism*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006736:Horses / Q000378:metabolism*; D008099:Liver / Q000737:chemistry; D008297:Male; D009132:Muscles / Q000737:chemistry; D011897:Random Allocation; D064586:Selenic Acid; D012643:Selenium / Q000008:administration & dosage / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*; D018036:Selenium Compounds; D012756:Sheep / Q000378:metabolism*; D018038:Sodium Selenite
chemical_list: D018036:Selenium Compounds; D005979:Glutathione Peroxidase; D012643:Selenium; D018038:Sodium Selenite; D064586:Selenic Acid