Evidence for the prevention of oxidative tissue damage in the inner eye by vitamins E and C.
The injection of oxidative metabolites such as lipid peroxides (LPO) into the vitreous cavity led to tissue damage demonstrable by a dose-dependent increase in intravitreal and intralental LPO levels, which are expressed as thiobarbituric-acid-reactive substances (TBARS). This process was accompanied by an inflammatory response as indicated by the occurrence of leukocyte-derived myeloperoxidase (MPO) in the vitreous body. Intramuscular injections of vitamin E were very effective in reducing both TBARS and MPO activity, whereas vitamin C had a moderate effect on TBARS only. The injection of a combination of the two vitamins was no more effective than treatment with vitamin E alone.
Augustin
A J
AJ
Department of Clinical Ophthalmology, University of Bonn, Federal Republic of Germany.
Breipohl
W
W
Böker
T
T
Wegener
A
A
D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use*; D005260:Female; D007908:Lens, Crystalline / Q000378:metabolism; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000633:toxicity*; D009504:Neutrophils / Q000201:enzymology; D009195:Peroxidase / Q000378:metabolism; D011817:Rabbits; D012162:Retinal Degeneration / Q000209:etiology / Q000517:prevention & control*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014810:Vitamin E / Q000627:therapeutic use*; D014822:Vitreous Body / Q000187:drug effects / Q000378:metabolism
D008054:Lipid Peroxides; D017392:Thiobarbituric Acid Reactive Substances; D014810:Vitamin E; D009195:Peroxidase; D001205:Ascorbic Acid