The use of feline herpesvirus and baculovirus as vaccine vectors for the gag and env genes of feline leukaemia virus.
The env and gag genes from feline leukaemia virus were expressed in a thymidine kinase-negative feline herpes-virus and a baculovirus. Cats were vaccinated with various combinations of these recombinant viruses and 100% protection against feline leukaemia virus challenge was achieved using an immunization schedule which utilized both env and gag products delivered at both a mucosal and systemic site.
Wardley
R C
RC
Animal Health Therapeutics Research, Upjohn Company, Kalamazoo, Michigan 49001-0199.
Berlinski
P J
PJ
Thomsen
D R
DR
Meyer
A L
AL
Post
L E
LE
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D016367:Baculoviridae / Q000235:genetics*; D002415:Cats; D015752:Genes, env; D015750:Genes, gag; D005822:Genetic Vectors; D006564:Herpesviridae / Q000235:genetics*; D005256:Leukemia Virus, Feline / Q000235:genetics / Q000276:immunology*; D011995:Recombination, Genetic; D015682:Retroviridae Proteins, Oncogenic / Q000008:administration & dosage / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology
D000914:Antibodies, Viral; D015682:Retroviridae Proteins, Oncogenic; D014765:Viral Vaccines; C045569:feline leukemia virus vaccine