title: Bacterial chemistry. VI. Biological activities and cytotoxicity of 1,3-dihydro-2H-indol-2-one derivatives.
abstract: The biosynthetic pigment from Chromobacterium violaceum BB-78, 1,3-dihydro-2H-indol-2-one and its derivatives exhibit biological activities such as antimicrobial action, low hemolytic effects on red blood cells and in vitro trypanocide activity. A relatively high cytotoxicity on V-79 hamster fibroblast cells of the biosynthetic pigment was found, although with the methylol derivative the toxicity was almost eliminated. The methylol derivative exhibited similar toxicity as Nifurtimox, a known, commercial trypanocide compound.
authors.affiliation: Departamento de Bioquímica, Instituto de Biología, Universidade Estadual de Campinas, S. P., Brazil.
authors.forename: M
authors.initials: M
authors.lastname: Haun
authors.forename: M F
authors.initials: MF
authors.lastname: Pereira
authors.forename: M E
authors.initials: ME
authors.lastname: Hoffmann
authors.forename: A
authors.initials: A
authors.lastname: Joyas
authors.forename: V
authors.initials: V
authors.lastname: Campos
authors.forename: L D
authors.initials: LD
authors.lastname: Filardi
authors.forename: S L
authors.initials: SL
authors.lastname: de Castro
authors.forename: N
authors.initials: N
authors.lastname: Duran
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000633:toxicity*; D001419:Bacteria / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002861:Chromobacterium / Q000254:growth & development / Q000378:metabolism*; D006224:Cricetinae; D005347:Fibroblasts / Q000187:drug effects; D006461:Hemolysis; D007211:Indoles / Q000302:isolation & purification / Q000633:toxicity*; D008826:Microbial Sensitivity Tests; D009547:Nifurtimox / Q000633:toxicity; D010860:Pigments, Biological / Q000302:isolation & purification / Q000633:toxicity*; D014349:Trypanosoma cruzi / Q000187:drug effects / Q000254:growth & development
chemical_list: D000900:Anti-Bacterial Agents; D007211:Indoles; D010860:Pigments, Biological; D009547:Nifurtimox