Beta-adrenoceptor modulation in a case of pure autonomic failure.
In a patient with pure autonomic failure, exercise did not modify beta-adrenoceptor density, probably due to an insufficient increase in plasma catecholamines. Isoproterenol infusion increased the number of beta-adrenoceptor by only 17%. Since in control subjects an increased beta-adrenoceptor level was found, following both physical stress and isoproterenol infusion, we suggest that the lack of increased beta-adrenoceptor levels may contribute to the poor circulatory adjustments observed in autonomic dysfunction during activities involving the sympathetic nervous system.
Perna
S
S
Department of Medicine, 2nd Medical School, University of Naples, Italy.
Leone
R
R
Farace
M J
MJ
Brescia-Morra
V
V
Campanella
G
G
Brevetti
G
G
D001342:Autonomic Nervous System Diseases / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology; D002395:Catecholamines / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D015444:Exercise / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D011311:Pressoreceptors / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology*
D002395:Catecholamines; D011943:Receptors, Adrenergic, beta; D007545:Isoproterenol