Kinin contribution to chronic antihypertensive actions of ACE-inhibitors in hypertensive rats.
The contribution of endogenous bradykinin to the chronic antihypertensive actions of the ACE-inhibitor, ramipril, was investigated in 2-kidney 1 clip (2K1C) hypertensive kinin-deficient Brown Norway Katholieke rats (BN-K) and 2K1C hypertensive Wistar rats (WI) as well as in spontaneously hypertensive rats (SHR). Treatment with ramipril plus the BK B2-receptor antagonist HOE 140 for 6 weeks significantly attenuated the antihypertensive effects of the ACE-inhibitor in 2K1C hypertensive WI rats, but not in 2K1C hypertensive BN-K rats and in SHR. Our data support the hypothesis that potentiation of endogenous kinins contributes to the chronic antihypertensive actions of ACE-inhibitors in experimental renal hypertension. Whether this holds also true for other forms of hypertension remains to be answered.
Bao
G
G
Department of Pharmacology, University of Heidelberg, Germany.
Gohlke
P
P
Unger
T
T
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001920:Bradykinin / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects*; D006978:Hypertension, Renovascular / Q000503:physiopathology*; D017257:Ramipril / Q000494:pharmacology*; D051381:Rats; D011914:Rats, Inbred BN; D011918:Rats, Inbred SHR; D017208:Rats, Wistar; D018002:Receptors, Bradykinin; D017981:Receptors, Neurotransmitter / Q000037:antagonists & inhibitors; D013045:Species Specificity
D018002:Receptors, Bradykinin; D017981:Receptors, Neurotransmitter; C065679:icatibant; D017257:Ramipril; D001920:Bradykinin