Lymphoma induction by human B cells in scid mice.
Lymphoma development was studied in scid mice injected i.p. with PBMC from EBV-positive donors. Most injected mice developed oligo/monoclonal B-cell tumors within 4 months after the inoculation; EBV genome was found in tumor cells. Removal of T lymphocytes from the injected cell populations prevented lymphoma development in all mice, suggesting that T-cell-derived factors are involved in the expansion of the latently EBV-infected B-cell population within the immunodeficient host.
Amadori
A
A
Institute of Oncology, University of Padova, Italy.
Veronese
M L
ML
Mazza
M R
MR
Zamarchi
R
R
Mion
M
M
D'Andrea
E
E
Menin
C
C
Del Mistro
A
A
Leszl
A
A
Calderazzo
F
F
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000637:transplantation*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D016867:Immunocompromised Host; D016393:Lymphoma, B-Cell / Q000276:immunology* / Q000382:microbiology; D051379:Mice; D016513:Mice, SCID; D010641:Phenotype