[The role of dermorfin in regulating hibernation processes in mammals].
Administration of dermorphin (0.1 mg/kg, subcutaneously) induced a drop of body temperature, deceleration of initial vegetative parameters and development of hibernation-like state in susliks. The delayed effects involved a disorder in conditioning. The immunisation of hibernating susliks with the dermorphin conjugate leads to a gradual waking up of the animals, normalising of conditioning in all the parameters and occurrence of a motor component in avoidance conditioning. A possible specific role of the dermorphin in the mechanisms of hibernation, is discussed.
Sollertinskaia
T N
TN
Nuritdinov
E N
EN
Obukhova
M F
MF
D000161:Acoustic Stimulation; D000818:Animals; D001831:Body Temperature / Q000187:drug effects / Q000502:physiology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D004558:Electric Stimulation; D005620:Freund's Adjuvant / Q000494:pharmacology; D005976:Glutaral / Q000494:pharmacology; D006605:Hibernation / Q000187:drug effects* / Q000502:physiology; D006613:Higher Nervous Activity / Q000187:drug effects / Q000502:physiology; D007114:Immunization; D009842:Oligopeptides / Q000276:immunology / Q000494:pharmacology*; D018847:Opioid Peptides; D012589:Sciuridae; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D014851:Wakefulness / Q000187:drug effects / Q000502:physiology
D009842:Oligopeptides; D018847:Opioid Peptides; C078778:dermorphin conjugate; D012710:Serum Albumin, Bovine; C030058:dermorphin; D005620:Freund's Adjuvant; D005976:Glutaral
Rol' dermorfina v reguliatsii protsessov zimneĭ spiachki u mlekopitaiushchikh.