[Effect of ketotifen, nedocromil sodium and budesonide on non-specific bronchial hyperreactivity to histamine in patients with asthma].
The aim of the study was to evaluate the effect of ketotifen, nedocromil sodium and budesonide on non-specific bronchial hyperreactivity in asthmatic patients. The study was performed on a group of 40 patients treated with these drugs for a period of 4-12 weeks. Bronchial provocation with histamine was carried out in all patients before and after therapy. In subjects receiving ketotifen an additional provocation test was performed 3 days and 4 weeks after commencement of treatment. The results showed that drugs inhibiting the release of mediators from mast cells or diminishing the late phase of bronchial allergic reaction significantly reduce non-specific bronchial hyperreactivity.
Siergiejko
Z
Z
Kliniki Alergologii AM, Białymstoku.
Rutkowski
R
R
Rogalewska
A
A
Kazberuk
M
M
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy*; D001985:Bronchial Provocation Tests; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D019819:Budesonide; D005260:Female; D006801:Humans; D007665:Ketotifen / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D017835:Nedocromil; D011282:Pregnenediones / Q000627:therapeutic use*; D015363:Quinolones / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001993:Bronchodilator Agents; D011282:Pregnenediones; D015363:Quinolones; D017835:Nedocromil; D019819:Budesonide; D007665:Ketotifen
Wpływ ketotyfenu, nedokromilu oraz budezonidu na nadreaktywność oskrzli oceniana testem histaminowym u chorych na astme oskrzelowa.