Interpretive criteria and quality control guidelines for lomefloxacin and meropenem in susceptibility tests of Haemophilus influenzae using Haemophilus test medium.
Lomefloxacin and meropenem were tested in a multilaboratory study to establish susceptibility testing interpretive criteria and quality control (QC) guidelines for Haemophilus influenzae using Haemophilus test medium (HTM). Interpretive criteria were established by using triplicate testing of 102 representative H. influenzae strains. Only a susceptible category was proposed for lomefloxacin (greater than or equal to 22 mm and less than or equal to 2 micrograms/ml) and meropenem (greater than or equal to 13 mm and less than or equal to 4 micrograms/ml) due to the lack of resistant isolates. QC range for H. Influenzae ATCC 49247 were established using multiple HTM agar and broth base lots, three disk lots for each drug, and a number of test replicates consistent with the National Committee for Clinical Laboratory Standards M23-T guideline.
Pfaller
M A
MA
University of Iowa College of Medicine, Iowa City.
Jones
R N
RN
Washington
J A
JA
Koontz
F P
FP
Gerlach
E H
EH
Erwin
M E
ME
D000890:Anti-Infective Agents / Q000494:pharmacology*; D003470:Culture Media; D024841:Fluoroquinolones; D006193:Haemophilus influenzae / Q000187:drug effects*; D006801:Humans; D000077731:Meropenem; D008826:Microbial Sensitivity Tests / Q000592:standards*; D011786:Quality Control; D015363:Quinolones / Q000494:pharmacology*; D012044:Regression Analysis; D013845:Thienamycins / Q000494:pharmacology*
D000890:Anti-Infective Agents; D003470:Culture Media; D024841:Fluoroquinolones; D015363:Quinolones; D013845:Thienamycins; D000077731:Meropenem; C053091:lomefloxacin