The effect of haemorrhage on erythropoietin concentration in the mature ovine fetus.
This study examines the response in plasma erythropoietin values to haemorrhage of 20% of the estimated blood volume in chronically cannulated ovine fetuses, of gestational ages 128-144 days. Blood samples were collected at 0, 2, 4, 6 and 24h with respect to the haemorrhage. In 5 control experiments there was no significant change in plasma erythropoietin concentration, across this time period, values being 6.1 +/- 2.3 and 6.4 +/- 2.4 mU/ml at 0 and 24h respectively. Values are mean +/- SEM. Haemorrhage reduced the haematocrit and haemoglobin values, significantly, to 83 +/- 6% and 85 +/- 4% (n = 5) of the initial value, respectively, but did not cause a statistically significant increase in plasma erythropoietin concentrations (7.2 +/- 2.4 and 20.7 +/- 8.2 mU/ml; P = 0.131). A larger degree of haemorrhage, in four fetuses reduced the haematocrit to 64 +/- 2.8% of initial, over 24-54h and increased erythropoietin values very significantly (from 11.9 +/- 3.6 to 91 +/- 8.3 mU/ml; P = 0.001).
Moritz
K M
KM
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Australia.
Cooper
E
E
Wintour
E M
EM
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D001784:Blood Gas Analysis; D004921:Erythropoietin / Q000097:blood*; D005333:Fetus / Q000378:metabolism*; D005786:Gene Expression Regulation; D005865:Gestational Age; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006470:Hemorrhage / Q000378:metabolism*; D012756:Sheep
D006454:Hemoglobins; D004921:Erythropoietin; D000324:Adrenocorticotropic Hormone