Thiazide therapy for ACTH-induced hypercalciuria and nephrolithiasis.
A one-year-old boy presented with hypercalciuria and nephrolithiasis following a course of ACTH therapy for infantile spasms. After a successful cystolithotripsy, therapy with chlorothiazide was followed by regression of the hypercalciuria within 42 months. Neither nephrolithiasis nor nephrocalcinosis recurred. Therapy with thiazides to prevent hypercalciuria caused by ACTH is proposed.
Katzir
Z
Z
Nephrology Service, Hadassah University Hospital, Jerusalem, Israel.
Shvil
Y
Y
Landau
E H
EH
Popovtzer
M M
MM
D000324:Adrenocorticotropic Hormone / Q000009:adverse effects* / Q000627:therapeutic use; D002118:Calcium / Q000037:antagonists & inhibitors / Q000652:urine*; D002121:Calcium Channel Blockers; D002740:Chlorothiazide / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006801:Humans; D007223:Infant; D007669:Kidney Calculi / Q000139:chemically induced / Q000628:therapy* / Q000652:urine; D008096:Lithotripsy; D008297:Male; D013036:Spasms, Infantile / Q000188:drug therapy*
D002121:Calcium Channel Blockers; D002740:Chlorothiazide; D000324:Adrenocorticotropic Hormone; D002118:Calcium