Enormous catalyses of lanthanide metal ions for unprecedentedly fast hydrolysis of 3',5'-cyclic adenosine monophosphate.
3',5'-cyclic adenosine monophosphate (cAMP) is efficiently hydrolyzed by use of lanthanide metal(III) ions as catalysts. The acceleration by 10(-2) M of Ce(III) is remarkable (more than 10(11) fold) at pH 8.0, 30 degrees C, decreasing the half-life from a half million years to 35 seconds. The catalytic activity is in the following order: Ce >> Pr > Nd, La > Y, Sm, Dy > others. The catalysis is ascribed to cooperation of three or four lanthanide metal ions.
Sumaoka
J
J
Institute of Materials Science, University of Tsukuba, Ibaraki, Japan.
Yashiro
M
M
Komiyama
M
M
D002384:Catalysis; D000242:Cyclic AMP / Q000737:chemistry*; D006868:Hydrolysis; D007700:Kinetics; D008674:Metals, Rare Earth / Q000737:chemistry*
D008674:Metals, Rare Earth; D000242:Cyclic AMP