title: Histopathological prediction of liver metastasis after curative resection of colorectal cancer.
abstract: To estimate the risk of liver metastasis after curative resection of colorectal cancer, resected specimens from 290 patients (45 with metachronous liver metastasis) were examined and the relationships between 10 histopathological variables and liver metastasis were analysed using our application of the Akaike information criterion (AIC). Of the 10 variables examined, the depth of venous invasion (Vd) had the greatest prognostic value for metastasis, followed by the number of venous invasions, the number of lymphovascular invasions, lymph node metastasis and type of infiltration. The prediction of liver metastasis was further improved by combining Vd with lymphocyte infiltration, mucinous production, interstitial fibrosis or depth of penetration, although these four variables per se were minimally informative for metastasis. We conclude that the prediction of liver metastasis is best achieved by combining Vd with other variables. Our risk group classification, and the estimated probability of liver metastasis for each group, are shown.
authors.affiliation: First Department of Surgery, Faculty of Medicine and Research Center for Biomedical Engineering, Kyoto University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yamazoe
authors.forename: S
authors.initials: S
authors.lastname: Maetani
authors.forename: H
authors.initials: H
authors.lastname: Onodera
authors.forename: T
authors.initials: T
authors.lastname: Nishikawa
authors.forename: T
authors.initials: T
authors.lastname: Tobe
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000473:pathology* / Q000556:secondary* / Q000601:surgery; D000465:Algorithms; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016013:Likelihood Functions; D008113:Liver Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000556:secondary*; D008207:Lymphatic Metastasis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012307:Risk Factors