title: Prevalence of antibody to Epstein-Barr virus DNase in children.
abstract: Antibodies to Epstein-Barr-virus-specific DNase in children under 15 years old from Taipei, Taiwan were determined by an enzyme neutralization test. Serum was taken as positive for the anti-DNase antibody when 1 ml of serum could neutralize > or = 2 units of the DNase activity. Among the 1,292 sera tested, 5.6% of the children were shown to have anti-EBV DNase antibodies, a result similar to that for adults. Maternal antibodies against the EBV DNase were found to decrease very rapidly 2 months after the child's birth, and new antibody appeared upon natural EBV infection.
authors.affiliation: Department of Bacteriology, National Taiwan University, Taipei, Republic of China.
authors.forename: M Y
authors.initials: MY
authors.lastname: Liu
authors.forename: S M
authors.initials: SM
authors.lastname: Cho
authors.forename: W S
authors.initials: WS
authors.lastname: Tsai
authors.forename: M H
authors.initials: MH
authors.lastname: Chang
authors.forename: J Y
authors.initials: JY
authors.lastname: Chen
authors.forename: C S
authors.initials: CS
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003851:Deoxyribonucleases / Q000276:immunology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000201:enzymology / Q000276:immunology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009500:Neutralization Tests; D015995:Prevalence; D013624:Taiwan / Q000453:epidemiology; D014412:Tumor Virus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D003851:Deoxyribonucleases