title: [Ethnic factors and their relation to the pathogenesis and geography of multiple sclerosis].
abstract: Epidemiological and immunogenetic studies made in patients with multiple sclerosis (MS), carried out for the first time in Uzbekistan, demonstrated the varying disease incidence in 4 populations: Uzbek, Tadjik, Russian and Tatar. In Uzbeks and Russians, a significant relationship was established between MS and antigen HLA-B7 carriership. A correlation was noted between the low incidence of MS among Uzbeks (0.8:100,000) and the higher among Russians (11.5:100,000) and the low prevalence of antigen HLA-B7 in the Uzbek and the higher one in the Russian population. It has been shown that the use of the medico-geographic mapping to specify the nature of MS is ineffective without regard to ethnic factors.
authors.forename: B A
authors.initials: BA
authors.lastname: Alaev
mesh_terms: D044466:Asian People / Q000235:genetics*; D005260:Female; D015789:HLA-A2 Antigen / Q000235:genetics*; D015791:HLA-A3 Antigen / Q000235:genetics*; D015793:HLA-B7 Antigen / Q000235:genetics*; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000208:ethnology* / Q000209:etiology / Q000235:genetics; D012424:Rural Population; D014505:Urban Population; D014610:Uzbekistan / Q000453:epidemiology / Q000208:ethnology; D044465:White People / Q000235:genetics*
chemical_list: D015789:HLA-A2 Antigen; D015791:HLA-A3 Antigen; D015793:HLA-B7 Antigen
vernacular_title: Etnicheskie faktory, sviaz' s patogenezom i geografieĭ rasseiannogo skleroza.