Lichen planus, liver kidney microsomal (LKM1) antibodies and hepatitis C virus antibodies.
No anti-liver kidney microsomal (LKM1) antibodies were detected in 46 patients with LP, 16 of whom had also a chronic liver disease (CLD). In contrast, anti-hepatitis C virus (HCV) antibodies were found in 10% of patients with LP and in 50% of those with LP and CLD. Anti-HCV antibodies may be considered as a false-positive reaction in 56% of cases, especially when anti-LKM1 antibodies are present. Our findings do not support such a hypothesis, but suggest that CLD in LP patients is, at least in Italy, mostly a postviral chronic active hepatitis.
Divano
M C
MC
Department of Dermatology, University of Genoa, Italy.
Parodi
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Rebora
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D001323:Autoantibodies / Q000097:blood*; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D005189:False Positive Reactions; D005260:Female; D005455:Fluorescent Antibody Technique; D016174:Hepacivirus / Q000276:immunology*; D006508:Hepatitis Antibodies / Q000097:blood*; D006515:Hepatitis B virus / Q000276:immunology; D006801:Humans; D008010:Lichen Planus / Q000150:complications / Q000276:immunology*; D008107:Liver Diseases / Q000150:complications / Q000276:immunology*; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies
D001323:Autoantibodies; D006508:Hepatitis Antibodies; C060729:anti-liver kidney microsome antibody