The molecular basis of the inhibition of collagenase by vitamin A.
Retinoic acid inhibits the enzyme collagenase by forming an inactive complex between the liganded nuclear retinoic acid receptors and c-Jun, a protein that is itself an activator of the collagenase gene.
Wolf
G
G
Department of Nutritional Sciences, University of California, Berkeley 94720.
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D017364:Collagenases / Q000235:genetics; D003315:Cornea / Q000201:enzymology; D004247:DNA / Q000378:metabolism; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism; D018168:Receptors, Retinoic Acid; D014801:Vitamin A / Q000378:metabolism / Q000494:pharmacology*
D002352:Carrier Proteins; D061965:Matrix Metalloproteinase Inhibitors; D016755:Proto-Oncogene Proteins c-jun; D018168:Receptors, Retinoic Acid; D014801:Vitamin A; D004247:DNA; D017364:Collagenases