Transcriptional regulation and transpositional selection of active SINE sequences.
Alu repeats are short interspersed elements whose transposition has lead to genetic variability and heritable disorders in humans. A select subset of the nearly one million Alu sequences in human DNA actually produce new transpositions. The evolution of newly inserted Alu repeats is currently a key subject for study. Mechanisms of RNA polymerase III activity and the sequence environment into which an Alu inserts might select for transcriptional and posttranscriptional determinants of Alu transposition.
Schmid
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C
Department of Genetics, University of California, Davis 95616.
Maraia
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R
D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D004251:DNA Transposable Elements; D005786:Gene Expression Regulation; D006801:Humans; D008969:Molecular Sequence Data; D012091:Repetitive Sequences, Nucleic Acid; D014158:Transcription, Genetic
D004251:DNA Transposable Elements