title: Nucleotide sequence of endothelin-1 cDNA from rabbit endothelial cells.
abstract: A cDNA encoding rabbit endothelin-1 (ET-1) was isolated by plaque hybridization from a rabbit inferior vena caval endothelial cell lambda gt11 cDNA library using human ET-1 cDNA as the hybridization probe. DNA sequence analysis indicates that mature 21 amino acid rabbit ET-1 is derived from a 202 amino acid precursor, via a 39 amino acid intermediate 'big' ET-1.
authors.affiliation: Department of Medicine, St. Michael's Hospital, Toronto, Canada.
authors.forename: P A
authors.initials: PA
authors.lastname: Marsden
authors.forename: P
authors.initials: P
authors.lastname: Sultan
authors.forename: M
authors.initials: M
authors.lastname: Cybulsky
authors.forename: M A
authors.initials: MA
authors.lastname: Gimbrone
authors.forename: B M
authors.initials: BM
authors.lastname: Brenner
authors.forename: T
authors.initials: T
authors.lastname: Collins
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004247:DNA; D019332:Endothelin-1; D016232:Endothelins / Q000737:chemistry / Q000235:genetics*; D004730:Endothelium, Vascular / Q000737:chemistry*; D008969:Molecular Sequence Data; D011498:Protein Precursors / Q000737:chemistry / Q000235:genetics; D011817:Rabbits; D012689:Sequence Homology, Nucleic Acid
chemical_list: D019332:Endothelin-1; D016232:Endothelins; D011498:Protein Precursors; D004247:DNA