title: Pathogenicity and preliminary antigenic characterization of six infectious bursal disease virus strains isolated in France from acute outbreaks.
abstract: Six isolates originating from acute outbreaks of infectious bursal disease recently reported in broiler and pullet flocks in France were studied with respect to their pathogenicity and their antigenic relatedness to the Faragher 52/70 reference strain. Although the mortality experimentally induced in susceptible chickens by the field strains was sometimes four times higher than that which followed the inoculation of the reference strain (16 to 48% versus 12%), neither mortality nor morbidity were observed in chickens previously vaccinated with a commercial live vaccine and then challenged under the same conditions. Agar gel precipitation tests demonstrated the existence of common antigens in the different strains, and high cross-neutralization indices measured in embryonated specific pathogen free eggs showed them all to belong to serotype I. These data are discussed with reference to previous European and North-American studies on the antigenic status of infectious bursal disease virus.
authors.affiliation: CNEVA-Laboratoire Central de Recherches Avicole et Porcine, Unité de Pathologie Aviaire, France.
authors.forename: N
authors.initials: N
authors.lastname: Eterradossi
authors.forename: J P
authors.initials: JP
authors.lastname: Picault
authors.forename: P
authors.initials: P
authors.lastname: Drouin
authors.forename: M
authors.initials: M
authors.lastname: Guittet
authors.forename: R
authors.initials: R
authors.lastname: L'Hospitalier
authors.forename: G
authors.initials: G
authors.lastname: Bennejean
mesh_terms: D000208:Acute Disease; D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D002645:Chickens; D004196:Disease Outbreaks / Q000662:veterinary*; D005260:Female; D005602:France / Q000453:epidemiology; D007243:Infectious bursal disease virus / Q000276:immunology / Q000472:pathogenicity*; D008297:Male; D012088:Reoviridae Infections / Q000453:epidemiology / Q000382:microbiology*; D013047:Specific Pathogen-Free Organisms; D014611:Vaccination / Q000662:veterinary
chemical_list: D000956:Antigens, Viral