Recurrent herpetic keratitis during topical acyclovir application.
Dendritic herpetic keratitis developed in a 49-year-old patient during topical acyclovir treatment. A positive herpes simplex culture was obtained. After acyclovir was replaced by trifluorothymidine and interferon, the dendritic lesion disappeared and herpes simplex culture became negative. Six months later a carcinoma of the larynx was diagnosed. The acyclovir-resistant herpetic keratitis may be associated with the carcinoma because resistant herpes simplex virus strains are predominantly described in patients suffering from immune deficiency.
Soriano
J M
JM
Universitäts-Augenklinik Freiburg, Germany.
Funk
J
J
Janknecht
P
P
Matz
B
B
D000212:Acyclovir / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use; D016898:Interferon-alpha; D016849:Keratitis, Herpetic / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011994:Recombinant Proteins; D012008:Recurrence; D018139:Simplexvirus / Q000187:drug effects; D014271:Trifluridine / Q000627:therapeutic use
D007370:Interferon Type I; D016898:Interferon-alpha; D009883:Ophthalmic Solutions; D011994:Recombinant Proteins; D014271:Trifluridine; C554129:interferon alfa-2c; D000212:Acyclovir