Presynaptic control as a mechanism of sensory-motor integration.
In studies of central nervous system networks, it is synaptic transmission to the postsynaptic soma-dendritic membrane that has received the most attention, in particular in relation to the analysis of sensory-motor integration. Sensory transmission is gated during ongoing movements in both invertebrates and vertebrates, such that it may be depressed in one phase of a cyclic movement and facilitated in another, in order to optimize the execution of the ongoing motor task. This presynaptic modulation is not limited to sensory afferents, but also occurs in synapses of both excitatory and inhibitory premotor interneurons. The modulation can be mediated by the release of different transmitters at axo-axonal synapses, which activate different types of receptors. In addition, presynaptic sensory axons can be coupled via gap junctions, which under certain conditions may mediate a presynaptic facilitation.
Clarac
F
F
CNRS, Marseille, France.
el Manira
A
A
Cattaert
D
D
D000200:Action Potentials; D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D003400:Astacoidea / Q000502:physiology; D002415:Cats / Q000502:physiology; D018118:Chloride Channels; D004558:Electric Stimulation; D019204:GTP-Binding Proteins; D015640:Ion Channel Gating; D008124:Locomotion / Q000502:physiology; D008565:Membrane Proteins / Q000502:physiology; D008959:Models, Neurological; D009043:Motor Activity / Q000502:physiology*; D011963:Receptors, GABA-A / Q000502:physiology; D012677:Sensation / Q000502:physiology*; D015398:Signal Transduction; D009435:Synaptic Transmission / Q000502:physiology*
D018118:Chloride Channels; D008565:Membrane Proteins; D011963:Receptors, GABA-A; D019204:GTP-Binding Proteins