[The efficacy of the bothropic-crotalic antivenom in the neutralization of the main Bothrops jararacussu venom effects].
Myonecrosis is one of the effects of Bothrops jararacussu venom, from which a myotoxin was isolated showing structural homology to phospholipase A2 (PLA2), but without enzymatic activity. Such myotoxic activity is also present in the Crotalus durissus terrifucus venom, and is attributed to crotoxin and to PLA2 (crotoxin B), the basic component of the crotoxin complex. The Bothrops jararacussu venom showed three proteins with immunologic identity to PLA2 from crotoxin. The bothropic (AB) and the bothropic/crotalic (AB/C) anti-venoms, two commercial polyvalent anti-venoms produced at Instituto Butantan, were compared in order to assess their capacity for neutralization of the lethal, hemorrhagic, coagulant and myotoxic activities of Bothrops jararacussu venom. Both anti-venoms showed the same level of hemorrhagic activity neutralization. However, AB/C was about three times more efficient than AB in neutralizing the myotoxic activity, and two times more potent for neutralization of lethality and coagulant activity of Bothrops jararacussu venom. These data suggest that the use of AB/C could be of value in the treatment of patients bitten by snakes of this species.
dos-Santos
M C
MC
Departamento de Imunologia, Universidade de São Paulo, Brasil.
Gonçalves
L R
LR
Fortes-Dias
C L
CL
Cury
Y
Y
Gutiérrez
J M
JM
Furtado
M de F
Mde F
D000818:Animals; D000997:Antivenins / Q000627:therapeutic use*; D017837:Bothrops; D003439:Crotoxin / Q000627:therapeutic use; D004797:Enzyme-Linked Immunosorbent Assay; D007116:Immunization, Passive; D008297:Male; D051379:Mice; D012910:Snake Venoms / Q000037:antagonists & inhibitors*
D000997:Antivenins; D012910:Snake Venoms; D003439:Crotoxin
A eficácia do antiveneno botrópico-crotálico na neutralização das principais atividades do veneno de Bothrops jararacussu.