[Excerpts from the investigations of pipecuronium bromide with NMR spectroscopy].
The synthesis of Pipecuronium bromide together with the investigation of its impurity profile required the solution of a number of analytical and structural problems. NMR spectroscopical methods received a major role in the structure elucidation of the synthesized compounds. The quantitative assessment of contaminations was also realized by 1H NMR spectroscopy. Out of the large amount of undertaken investigations, here we provide the structural characterization of the contaminating regiosimers of an important intermediate (5 alpha-androst-2-en-17-on) formed in the course of the synthesis, together with the NMR signal assignments of the end-product (Pipecuronium bromide) as measured in D2O and a mixture of CDCl3/DMSO-d6. The structure of a minor contamination of the end-product is also given.
Balogh
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Richter Gedeon Vegyészeti Gyár Rt., Budapest.
Tuba
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D015113:Androstane-3,17-diol / Q000031:analogs & derivatives* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D009466:Neuromuscular Blocking Agents / Q000737:chemistry*; D017300:Pipecuronium; D010879:Piperazines / Q000737:chemistry*
D009466:Neuromuscular Blocking Agents; D010879:Piperazines; D017300:Pipecuronium; D015113:Androstane-3,17-diol
Szemelvények a pipecuronium bromiddal kapcsolatos NMR spektroszkópiai vizsgálatokból.