[The vitamin D endocrine system and bone tissue mineral metabolism in rats with adjuvant arthritis: the effect of 1,25-dihydroxyvitamin D3].
Adjuvant arthritis was induced in male rats by injecting bacillus Calmette-Guèrin in mineral oil in a hindpaw. A decrease in bone density, calcium and phosphorus content due to polyarthritis was found in the tibia of the noninjected hind leg. Arthritic rats demonstrated serum 1,25-dihydroxyvitamin D deficiency along with constant level of 25-hydroxyvitamin D. The disease caused a significant expression of 1,25-dihydroxyvitamin D3 receptors in lymphocytes. Arthritic rats were treated with 1,25-dihydroxyvitamin D3 (0.15 mg/kg/day orally) for 35 days. The treatment prevented the development of osteoporosis and a decrease of 1,25-dihydroxyvitamin D levels as well as reduced the expression of 1,25-dihydroxyvitamin D receptors in lymphocytes.
Sergeev
I N
IN
Spirichev
V B
VB
Bogoslovskiĭ
N A
NA
Korsova
T L
TL
Morozova
N A
NA
Poznanskaia
A A
AA
D000818:Animals; D001169:Arthritis, Experimental / Q000188:drug therapy / Q000378:metabolism*; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000378:metabolism*; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D002117:Calcitriol / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004702:Endocrine Glands / Q000187:drug effects / Q000378:metabolism*; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008903:Minerals / Q000378:metabolism*; D051381:Rats; D018167:Receptors, Calcitriol; D011987:Receptors, Steroid / Q000187:drug effects / Q000378:metabolism; D014807:Vitamin D / Q000378:metabolism*
D008903:Minerals; D018167:Receptors, Calcitriol; D011987:Receptors, Steroid; D014807:Vitamin D; D002117:Calcitriol
Endokrinnaia sistema vitamina D i mineral'nyĭ obmen kostnoĭ tkani u krys s ad''iuvantnym artritom: vliianie 1,25-digidroksivitamina D3.