[Relationship between drug resistance and oncogenes in lung cancer cell lines].
The 5-year survival of lung cancer patients is about 30% in Japan. One of the reasons for the poor prognosis seems to be drug resistance. It has been reported that certain types of oncogenes, such as ras, myc and fos, may play an important role in drug resistance. The myc protein forms a sequence-specific DNA-binding complex with Max and may act as a transcription factor; thus, it may be possible that myc family oncogenes are involved in DNA synthesis and repair processes mediating drug resistance. We report here that L-myc oncogene may be involved in the transition from drug-sensitive to drug-resistant phenotype of a certain small cell lung cancer cell line.
Tanio
Y
Y
Department of Medicine III, Osaka University Medical School.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D018288:Carcinoma, Small Cell / Q000235:genetics*; D004351:Drug Resistance / Q000235:genetics; D016259:Genes, myc; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D051379:Mice; D014157:Transcription Factors; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D014157:Transcription Factors