Specificity of the anticollagenase action of tetracyclines: relevance to their anti-inflammatory potential.
The concentrations of doxycycline and 4-de-dimethylaminotetracycline required to inhibit 50% of collagenase activity were found to be 15 to 30 microM for human neutrophil and gingival crevicular fluid collagenases. Fibroblast collagenase was relatively resistant to inhibition by tetracyclines; the 50% inhibitory concentrations of doxycycline and 4-de-dimethylaminotetracycline were 280 and 510 microM, respectively.
Suomalainen
K
K
Department of Periodontology, University of Helsinki, Finland.
Sorsa
T
T
Golub
L M
LM
Ramamurthy
N
N
Lee
H M
HM
Uitto
V J
VJ
Saari
H
H
Konttinen
Y T
YT
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects / Q000201:enzymology; D006801:Humans; D003012:Microbial Collagenase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology; D013754:Tetracyclines / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D013754:Tetracyclines; D003012:Microbial Collagenase