Lectin histochemistry of sex cord-stromal tumors and small cell carcinoma of the ovaries.
Binding sites of peanut agglutinin (PNA), Ulex europaeus (UEA-1), concanavalin A (Con A), and wheat germ agglutinin (WGA) were localized in 10 granulosa cell tumors, 10 Sertoli-Leydig cell tumors, 4 theca cell tumors, and 5 small cell carcinomas. Con A and WGA reacted positively with the majority of the studied neoplasms. PNA and UEA-1 were persistently negative in the sex cord-stromal tumors (SCST) but showed focal positivity in small cell carcinomas. Negative reactions of SCST with PNA and UEA-1 may serve for differentiation between them and common epithelial tumors that are usually PNA and UEA-1 positive.
Bychkov
V
V
Department of Pathology, Mount Sinai School of Medicine, New York City, N.Y.
Deligdisch
L
L
Talerman
A
A
Reddy
V B
VB
D001665:Binding Sites; D018288:Carcinoma, Small Cell / Q000473:pathology*; D005069:Evaluation Studies as Topic; D005260:Female; D006106:Granulosa Cell Tumor / Q000473:pathology*; D006651:Histocytochemistry / Q000379:methods; D006801:Humans; D037102:Lectins; D007984:Leydig Cell Tumor / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000473:pathology*; D012707:Sertoli Cell Tumor / Q000473:pathology*; D013798:Thecoma / Q000473:pathology*
D037102:Lectins