Loss of transformed phenotype upon senescence of Rous sarcoma virus-infected chicken neuroretinal cells.
Success in obtaining permanent Rous sarcoma virus-infected chicken cell lines has been limited because of a senescence phenomenon. We show that a diminished, transformed phenotype, followed by dramatic morphological changes, precedes senescence. These changes are associated with continued expression of pp60v-src, as well as specific alterations in expression of two possible phosphorylated substrates of pp60v-src.
Seigel
G M
GM
Department of Neurobiology and Anatomy, University of Rochester Medical Center, New York 14642.
Notter
M F
MF
D000818:Animals; D001358:Avian Sarcoma Viruses / Q000502:physiology*; D015153:Blotting, Western; D002448:Cell Adhesion; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D016922:Cellular Senescence / Q000235:genetics*; D002642:Chick Embryo; D008938:Mitosis; D010641:Phenotype; D010750:Phosphoproteins / Q000378:metabolism; D012160:Retina / Q000382:microbiology*
D010750:Phosphoproteins