title: Rat brain hypothalamic and hippocampal monoamine and hippocampal beta-adrenergic receptor changes during pregnancy.
abstract: The concentration of noradrenaline (NA), dopamine (DA), serotonin (5-HT), and their metabolites was measured in hypothalamic and hippocampal brain tissue obtained from non-pregnant, 15- or 20-day pregnant and 4-day postpartum rats. At 20 days of pregnancy, hypothalamic NA and DA concentrations were significantly decreased and their turnover increased relative to postpartum and estrous values, respectively. Hippocampal 3-methoxy-4-hydroxy-phenylglycol (MHPG) levels were significantly decreased at 15 days of pregnancy and 4 days postpartum compared to estrous and 20-day pregnant levels and the MHPG/NA ratio was significantly reduced at 4 days postpartum relative to the estrous value. Hippocampal 5-HT and 5-hydroxyindole-3-acetic acid (5-HIAA) levels were significantly decreased at 15 days of pregnancy while 5-HIAA levels and the 5-HIAA/5-HT ratio were significantly decreased at 20 days of pregnancy. Hippocampal beta-adrenergic receptor density was significantly lower at 4 days postpartum than at 15 days of pregnancy. A positive correlation was observed between plasma progesterone and hippocampal beta-adrenoceptor Kd values, suggesting a possible causal relationship between these two variables. The monoamine and beta-adrenoceptor changes which occur during pregnancy may be an important contributing factor in determining the mood changes which occur during pregnancy and postpartum.
authors.affiliation: Department of Chemical Pathology, University of Stellenbosch, Tygerberg Hospital, South Africa.
authors.forename: J
authors.initials: J
authors.lastname: Glaser
authors.forename: V A
authors.initials: VA
authors.lastname: Russell
authors.forename: J J
authors.initials: JJ
authors.lastname: Taljaard
mesh_terms: D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D005260:Female; D006624:Hippocampus / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism*; D019964:Mood Disorders / Q000378:metabolism*; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D011644:Puerperal Disorders / Q000378:metabolism / Q000523:psychology; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
chemical_list: D015306:Biogenic Monoamines; D011943:Receptors, Adrenergic, beta; D011374:Progesterone