Proofreading, NTPases and translation: constraints on accurate biochemistry.
Two accurate individual reactions can work together as a more accurate overall mechanism. This is straightforward for a transient reaction, but the same accuracy in the steady state (termed proofreading) requires many preconditions. The preconditions for proofreading can be summarized as four statements, which allow experimental identification and subsequent confirmation of proofreading mechanisms.
Yarus
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Department of MCD Biology, University of Colorado, Boulder 80309-0347.
D008957:Models, Genetic; D043583:Nucleoside-Triphosphatase; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D014176:Protein Biosynthesis / Q000502:physiology*
D010744:Phosphoric Monoester Hydrolases; D043583:Nucleoside-Triphosphatase