title: Plasma tumor necrosis factor soluble receptors in chronic renal failure.
abstract: Two soluble tumor necrosis factor receptors (sTNFRs) were detected in the plasma of patients with different degrees of chronic renal failure (CRF) and of long-term hemodialysis (HD) patients. In uremic undialyzed patients, plasma levels of both sTNFRs increased progressively with declining renal function. A linear correlation was found between sTNFR plasma levels and plasma creatinine concentration. sTNFR levels in end-stage uremic patients shortly before commencement of first HD treatment were approximately tenfold higher than in normal subjects. Long-term HD patients showed a further increase in plasma sTNFRs. The origin of sTNFRs, as well as their physiological role remains to be elucidated.
authors.affiliation: Central Research Units F., Hoffmann-La Roche Ltd., Basel, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Brockhaus
authors.forename: Y
authors.initials: Y
authors.lastname: Bar-Khayim
authors.forename: S
authors.initials: S
authors.lastname: Gurwicz
authors.forename: A
authors.initials: A
authors.lastname: Frensdorff
authors.forename: N
authors.initials: N
authors.lastname: Haran
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007118:Immunoassay; D007668:Kidney / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D011956:Receptors, Cell Surface / Q000378:metabolism*; D018124:Receptors, Tumor Necrosis Factor; D006435:Renal Dialysis; D012995:Solubility; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D011956:Receptors, Cell Surface; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha