Involvement of the membrane-bound Na,K ATPase in the evolution of experimental injuries of the spinal cord.
Rat spinal cords have been compressed at the region corresponding to D4-D5 by a 50 mg/cm force. After 5, 30 and 60 min this section has been dissected together with the surrounding cord. The ATPase activity of the homogenates was decreased, suggesting an involvement of this enzyme in the generation of edema.
Nardi
P
P
Divisione di Neurochirurgia Lancisi, Ospedale S. Camillo, Roma, Italy.
Chiappetta
F
F
Giancola
R
R
Sinibaldi
P
P
Verna
R
R
D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D004487:Edema / Q000503:physiopathology; D006940:Hyperemia / Q000503:physiopathology; D007511:Ischemia / Q000503:physiopathology; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000032:analysis / Q000502:physiology*; D013116:Spinal Cord / Q000098:blood supply / Q000201:enzymology; D013117:Spinal Cord Compression / Q000201:enzymology* / Q000503:physiopathology; D013119:Spinal Cord Injuries / Q000201:enzymology* / Q000503:physiopathology
D009419:Nerve Tissue Proteins; D000254:Sodium-Potassium-Exchanging ATPase