Isolation and characterization of an antiviral flavonoid from Waldsteinia fragarioides.
The antiviral agent in a fraction from Waldsteinia fragarioides (Rosaceae) was purified using bioassay-guided fractionation of activity against herpes simplex type 1 virus. Structural eluciation by instrumental methods identified the active component to be the known flavonoid glycoside, isoquercitrin (3,3',4',5,7-pentahydroxyflavone-3 beta-O-glucoside), which had not previously been shown to possess antiviral activity.
Abou-Karam
M
M
Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis 55455.
Shier
W T
WT
D000998:Antiviral Agents / Q000302:isolation & purification* / Q000494:pharmacology; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D018139:Simplexvirus / Q000187:drug effects; D010948:Viral Plaque Assay
D000998:Antiviral Agents; D005419:Flavonoids; D010936:Plant Extracts