Morbidity risk factors in human cardiac transplantation. Histoincompatibility and protracted graft ischemia entail high risk of rejection and infection.
Data from the first 103 human heart transplantations performed on 100 recipients (aged 14-62 years) at a single center from November 1983 to January 1990 were analyzed in order to detect morbidity-causing risk factors. Cumulative one- and five-year graft survival was 82% and 68%. Multivariate analysis revealed three independent risk factors for early rejection, viz. HLA-DR and HLA-B mismatches and no prior cardiac surgery. Graft ischemic time exceeding 71 min was an independent risk factor for rejection, especially for moderate or severe events, and for infection. HLA-DR mismatch was an independent risk factor for moderate and severe rejection events and for infections. Finally, patients operated on because of end-stage ischemic heart disease were at significantly higher risk of rejection than those with other cardiac disorders. The study has several implications: Prospective tissue typing for cardiac transplantation and selection of donors may have an impact on graft function: Damage to the graft by prolonged ischemia may be reduced by improved organ preservation.
Foerster
A
A
Department of Pathology, Ullevål Hospital, Norway.
Abdelnoor
M
M
Geiran
O
O
Lindberg
H
H
Simonsen
S
S
Thorsby
E
E
Frøysaker
T
T
D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D003586:Cytomegalovirus Infections; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000209:etiology*; D015235:HLA-B Antigens / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis; D016027:Heart Transplantation / Q000009:adverse effects*; D006648:Histocompatibility; D006801:Humans; D007511:Ischemia / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D011020:Pneumonia, Pneumocystis / Q000209:etiology; D012307:Risk Factors; D013203:Staphylococcal Infections; D013530:Surgical Wound Infection / Q000209:etiology*; D013997:Time Factors
D015235:HLA-B Antigens; D006684:HLA-DR Antigens