Atrial natriuretic peptide and urinary dopamine output in non-insulin-dependent diabetes mellitus.
1. Disturbances of sodium and water homoeostasis may contribute to the close association between diabetes, hypertension and proteinuria. We therefore studied the patterns of two natriuretic hormones, plasma atrial natriuretic peptide and urinary dopamine, in 165 Chinese patients with non-insulin-dependent diabetes mellitus controlled by diet or oral hypoglycaemic agents on two occasions over a 6-week period. Patients were divided into three groups based on the mean value of two 24h urinary albumin excretion measurements. In group 1, 88 patients had normoalbuminuria (urinary albumin excretion < or = 30 mg/day), in group 2, 48 patients had microalbuminuria (urinary albumin excretion between 30 and 300 mg/day), and in group 3, 29 patients had macroalbuminuria (urinary albumin excretion > or = 300 mg/day). 2. The supine systolic blood pressure (mean +/- SD) was higher in patients with abnormal albuminuria (group 1: 140.9 +/- 27.4 mmHg; group 2: 158.1 +/- 26.4 mmHg; group 3: 166.7 +/- 23.9 mmHg; F = 13.1, P < 0.001, analysis of variance). Urinary sodium output was similar in these three groups of patients. The geometric means (anti-logarithm of 95% confidence interval logarithm) of plasma atrial natriuretic peptide concentrations increased with increasing proteinuria [group 1: 33.3 (29.9-37.1) pg/ml; group 2: 39.1 (34.2-44.6) pg/ml; group 3: 50 (38.6-54.7) pg/ml; F = 4.24, P < 0.01; analysis of variance], whereas those of urinary dopamine output were related inversely to proteinuria [group 1: 1291.7 (1167.2-1437.0) nmol/day; group 2: 1142.3 (975.9-1337.2) nmol/day; group 3: 982.7 (775.7-1245) nmol/day; F = 3.10, P < 0.05, analysis of variance].(ABSTRACT TRUNCATED AT 250 WORDS)
Chan
J C
JC
Department of Clinical Pharmacology, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin.
Critchley
J A
JA
Ho
C S
CS
Nicholls
M G
MG
Cockram
C S
CS
Swaminathan
R
R
D009320:Atrial Natriuretic Factor / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000652:urine*; D003925:Diabetic Angiopathies / Q000097:blood / Q000652:urine; D004298:Dopamine / Q000652:urine*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000652:urine; D008875:Middle Aged; D011507:Proteinuria / Q000097:blood / Q000652:urine
D009320:Atrial Natriuretic Factor; D004298:Dopamine