Na+K+ATPase activity and ouabain binding sites in erythrocytes in hyperthyroidism before and after treatment.
Erythrocyte sodium pump is decreased in hyperthyroid patients. We described the effect of untreated hyperthyroidism on Na+K+ATPase activity, ouabain binding sites and intracellular sodium concentration. We found a reduction in Na+K+ATPase activity and in number of ouabain binding sites with a concomitant increase in intracellular sodium. B-blockade therapy failed to restore normal pump activity and sodium concentration, where only thionamide treatment was successful when it was able to decrease free T3.
De Riva
C
C
Centro per le Malattie Endocrine e Metaboliche Ospedale Civile Umberto I, Mestre-Venezia, Italy.
Chen
S
S
Virgili
F
F
Frigato
F
F
D000328:Adult; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood* / Q000188:drug therapy / Q000201:enzymology; D008297:Male; D008713:Methimazole / Q000627:therapeutic use; D011188:Potassium / Q000097:blood; D011433:Propranolol / Q000627:therapeutic use; D011955:Receptors, Drug / Q000378:metabolism*; D012964:Sodium / Q000097:blood; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013960:Thyroid Function Tests
D011955:Receptors, Drug; C028996:cardiac glycoside receptors; D008713:Methimazole; D012964:Sodium; D011433:Propranolol; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium