Selective localization of C atrial natriuretic peptide receptors in the rat brain.
We studied the distribution of C atrial natriuretic peptide (C-ANP) receptors in the rat brain after incubation with 125I-rANP, and competition with the selective C-ANP receptor competitor C-ANP(4-23) (10(-6) M). C-ANP receptors were selectively localized to a few structures, the external plexiform layer of the olfactory bulb, the arachnoid mater and the choroid plexus, and their amount corresponds to 25%, 75% and 35%, respectively, of the ANP specific binding. These data suggest specialized functions for C-ANP receptors in brain.
Zorad
S
S
Section on Pharmacology, National Institute of Mental Health, Bethesda, MD 20892.
Tsutsumi
K
K
Saavedra
J M
JM
D000818:Animals; D009320:Atrial Natriuretic Factor; D001345:Autoradiography; D001923:Brain Chemistry / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D017461:Receptors, Atrial Natriuretic Factor; D011956:Receptors, Cell Surface / Q000032:analysis*
D011956:Receptors, Cell Surface; D009320:Atrial Natriuretic Factor; D017461:Receptors, Atrial Natriuretic Factor