Effects of diaphragmatic fatigue on phosphoinositide hydrolysis.
We evaluated the effects of diaphragmatic fatigue on muscle phosphatidylinositol phosphate (PIP) metabolism. Results revealed that the total PIP pool was 76% greater in fatigued rat diaphragms compared to controls, which suggests that fatigue was associated with inhibition of sarcolemmal membrane bound PIP hydrolysis.
Anderson
W M
WM
Department of Medicine, Veterans Affairs Medical Center, Shreveport, LA.
Zavecz
J H
JH
Tso
P
P
D000818:Animals; D003964:Diaphragm / Q000378:metabolism / Q000502:physiology*; D066298:In Vitro Techniques; D007294:Inositol / Q000378:metabolism; D009119:Muscle Contraction / Q000502:physiology*; D009132:Muscles / Q000378:metabolism / Q000502:physiology*; D010716:Phosphatidylinositols / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D010716:Phosphatidylinositols; D007294:Inositol