Hodgkin's disease and Epstein-Barr virus.
Seroepidemiological and molecular biological studies have established an association of Hodgkin's disease with Epstein-Barr virus (EBV). Recently, EBV genomes and gene products, most notably the latent membrane protein (LMP), have been detected in approximately 50% of the cases. The findings suggest that EBV may contribute to the pathoetiology of a sizable proportion of Hodgkin's disease cases.
Herbst
H
H
Institute of Pathology, Free University Berlin, Germany.
Pallesen
G
G
Weiss
L M
LM
Delsol
G
G
Jarrett
R F
RF
Steinbrecher
E
E
Stein
H
H
Hamilton-Dutoit
S
S
Brousset
P
P
D015703:Antigens, CD / Q000235:genetics; D000951:Antigens, Neoplasm / Q000235:genetics; D000956:Antigens, Viral / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D015967:Gene Expression Regulation, Viral / Q000235:genetics; D016679:Genome, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D006689:Hodgkin Disease / Q000209:etiology / Q000235:genetics / Q000382:microbiology*; D006801:Humans; D017730:Ki-1 Antigen; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics; D011379:Prognosis; D011506:Proteins / Q000235:genetics; D016601:RNA-Binding Proteins; D012269:Ribosomal Proteins
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D017730:Ki-1 Antigen; D011506:Proteins; D016601:RNA-Binding Proteins; D012269:Ribosomal Proteins; C067169:RPL22 protein, human