[The neuropharmacological restoration of cognitive functions in cats after damage to the forebrain basal nuclei (Meynert's nucleus)].
The cognitive functions were studied on experimental model of Alzheimer's disease (destruction of the basal nuclei of Meynert in cats) using the stimulation and inhibition of Ach, GABA, and DA brain systems. Ach system was found to be essential to form generalization function, DA system to improve simple learning, and GABA system to involve in formation of complex associations.
Mukhin
E I
EI
Nabieva
T N
TN
Mukhina
Iu K
IuK
D000544:Alzheimer Disease / Q000139:chemically induced / Q000503:physiopathology; D000818:Animals; D002415:Cats; D003071:Cognition / Q000187:drug effects* / Q000502:physiology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D005260:Female; D005793:Generalization, Psychological / Q000187:drug effects / Q000502:physiology; D007051:Ibotenic Acid; D008297:Male; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology; D013377:Substantia Innominata / Q000187:drug effects* / Q000502:physiology
D011950:Receptors, Cholinergic; D011954:Receptors, Dopamine; D011963:Receptors, GABA-A; D007051:Ibotenic Acid
Neĭrofarmakologicheskoe vosstanovlenie poznovatel'nykh funktsiĭ koshek posle porazheniia bazal'nykh iader perednego mozga (iadra Meĭnerta).