Macrophage function in the acute phase of lactic dehydrogenase virus-infection of mice: suppression of superoxide anion production in normal mouse peritoneal macrophages by interferon-alpha in vitro.
The effect of interferon (IFN)-alpha on the release of superoxide anions (O2-) by normal mouse macrophages (PEM) was examined. Sera from LDV-infected mice at 1 day, but not at 7 days post-infection, suppressed the O2- release by PEM. When PEM were exposed in vitro for 24 h to IFN-alpha, their capacity to release O2- was significantly suppressed. Progressive suppression of O2- release with increasing IFN-alpha concentration was observed. These results suggest that IFN-alpha in the circulation may be one of several suppressive factors on macrophage function in the early phase of infection and IFN-alpha may play a modulatory role in inflammation and immunity.
Hayashi
T
T
Laboratory of Veterinary Pathology, University of Yamaguchi, Japan.
Ozaki
M
M
Onodera
T
T
Ami
Y
Y
Yamamoto
H
H
D000818:Animals; D001202:Ascitic Fluid / Q000473:pathology; D002478:Cells, Cultured; D003864:Depression, Chemical; D016898:Interferon-alpha / Q000494:pharmacology*; D007772:Lactate dehydrogenase-elevating virus; D008262:Macrophage Activation / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010529:Peritoneal Cavity / Q000473:pathology; D013481:Superoxides / Q000378:metabolism*; D014036:Togaviridae Infections / Q000097:blood / Q000276:immunology* / Q000473:pathology
D016898:Interferon-alpha; D013481:Superoxides