[Intermediate-density lipoproteins and liver lipase in postmenopausal women].
In order to evaluate atherogenic lipoproteins in post-menopause, we studied 73 healthy women, 49 to 65 years old (Post-menopausal Group), with 1 to 10 years of amenorrhea and body mass index below 27 Kg/m2, and 20 young women (Control Group). We have determined plasma cholesterol concentration in the lipoproteins of intermediate density in addition to the classical lipoprotein parameters: total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides and fractionation of lipoproteins by electrophoresis. In 63 women from the Post-menopausal Group and 16 from the Control Group we studied the activity of hepatic lipase. Among these patients we selected at random 25 post-menopausal women and 13 controls to add measurements of triglycerides in the lipoproteins of intermediate density. Table 1 shows that the average plasma concentration of total cholesterol in the Post-menopausal Group was higher than that of the Controls (p < 0.001). The same was found for LDL-cholesterol (p < 0.001) and for triglycerides (p < 0.001) whereas the average concentration of HDL-cholesterol did not show significant differences. The Post-menopausal Group had high values of plasma lipoproteins of intermediate density, even with normal phenotypes (Table 2). Cholesterol but also triglycerides (Fig. 1) were responsible for this increase. A triglyceride rich lipoprotein subspecies of intermediate density was predominant in 73% of Post-menopausal women vs 23% of the Controls (p < 0.01, Table 3). No differences in hepatic lipase activity were seen between the two groups (Table 4), and non statistic correlation between the enzyme activity and IDL-triglycerides or HDL-cholesterol.(ABSTRACT TRUNCATED AT 250 WORDS)
Halperin
H
H
Departamento de Bioquímica Clínica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
Berg
G
G
Aisemberg
L
L
Brites
F
F
Siseles
N
N
Wikinski
R
R
D000368:Aged; D001161:Arteriosclerosis / Q000453:epidemiology; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D008049:Lipase / Q000032:analysis*; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D053419:Lipoproteins, IDL; D008099:Liver / Q000201:enzymology*; D008875:Middle Aged; D017698:Postmenopause / Q000378:metabolism*; D012307:Risk Factors
D008055:Lipids; D008074:Lipoproteins; D053419:Lipoproteins, IDL; D002784:Cholesterol; D008049:Lipase
Lipoproteínas de densidad intermedia y lipasa hepática en mujeres post-menopáusicas.