Effect of the NK-1 receptor antagonist GR 82,334 on reflexly-induced bladder contractions.
The effect of intrathecal administration of the novel tachykinin NK-1 receptor antagonist GR 82,334 has been tested in three reflexes which excite urinary bladder motility. GR 82,334 at 1 but not at 0.1 nmol/rat blocked the chemonociceptive micturition reflex induced by the topical application of capsaicin (4 micrograms/50 microliters) onto the urinary bladder. At the same dose proven effective in the chemonociceptive reflex, GR 82,334 did not affect either micturition reflex induced by bladder filling or the urinary bladder contraction induced by perineal pinching. These results suggest that, in urethane-anesthetized rats, specific stimuli applied in the periphery activate NK-1 receptors at spinal cord level facilitating urinary bladder reflex contractions.
Lecci
A
A
Pharmacological Research Department, A. Menarini Pharmaceuticals, Florence, Italy.
Giuliani
S
S
Maggi
C A
CA
D000818:Animals; D002211:Capsaicin / Q000494:pharmacology; D007278:Injections, Spinal; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D009475:Neurons, Afferent / Q000187:drug effects; D010803:Physalaemin / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D018041:Receptors, Neurokinin-2; D017981:Receptors, Neurotransmitter / Q000037:antagonists & inhibitors*; D001743:Urinary Bladder / Q000294:innervation; D014554:Urination
D018041:Receptors, Neurokinin-2; D017981:Receptors, Neurotransmitter; C079014:GR 82334; D010803:Physalaemin; D002211:Capsaicin