Transferrin binding of bone marrow cells and metabolic activity of erythrocytes after 5 Gy irradiation.
The effect of total body irradiation (5 Gy) on functional mouse erythroid lineage has been studied. The transferrin binding capacity by bone marrow cells and the activity of glycolytic regulatory enzymes and intracellular levels of 2,3 bisphosphoglycerate in peripheral blood erythrocytes have been determined. Results obtained along one year post-irradiation period suggest a complete recovery in the erythroid cell lineage with respect to the biological endpoints investigated.
Sancho
P
P
Departamento de Bioquímica y Biología Molecular, Universidad de Alcalá, Madrid, Spain.
Cuenllas
E
E
Gaitan
S
S
Tejero
C
C
D019794:2,3-Diphosphoglycerate; D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects*; D001854:Bone Marrow Cells; D004163:Diphosphoglyceric Acids / Q000097:blood / Q000528:radiation effects*; D004912:Erythrocytes / Q000201:enzymology / Q000528:radiation effects*; D006593:Hexokinase / Q000528:radiation effects; D051379:Mice; D008807:Mice, Inbred BALB C; D010732:Phosphofructokinase-1 / Q000528:radiation effects; D010770:Phosphotransferases / Q000097:blood / Q000528:radiation effects*; D011770:Pyruvate Kinase / Q000528:radiation effects; D011990:Receptors, Transferrin / Q000528:radiation effects*; D014168:Transferrin / Q000378:metabolism*; D014916:Whole-Body Irradiation
D004163:Diphosphoglyceric Acids; D011990:Receptors, Transferrin; D014168:Transferrin; D019794:2,3-Diphosphoglycerate; D010770:Phosphotransferases; D006593:Hexokinase; D010732:Phosphofructokinase-1; D011770:Pyruvate Kinase