Leukemic progression as process of adaptation (theoretical model).
On the basis of an assumption that leukemic progression is a process of adaptation of normal hemopoiesis to the effect of the leukemic clone, a theoretical model of leukemia development is built. General conclusions are as follows: the possibility of reaching remission depends upon suppression of normal hemopoiesis by cytostatics in a system of two cell populations: the duration of remission depends upon suppression of the leukemic clone; the quantity of blast cells of marrow in remission can exceed 5 per cent.
Alekseyev
I V
IV
All-Union Scientific Centre for Haematology of the USSR Ministry of Health, Department of Haematology and Bone Marrow Transplantation, Moscow.
D000222:Adaptation, Physiological / Q000502:physiology*; D006410:Hematopoiesis / Q000502:physiology; D006801:Humans; D007938:Leukemia / Q000503:physiopathology*; D008962:Models, Theoretical; D012075:Remission, Spontaneous