title: Tumour and tumour-like conditions of the soft tissue: magnetic resonance imaging features differentiating benign from malignant masses.
abstract: 49 primary soft-tissue masses were studied by magnetic resonance imaging (MRI) in an effort to differentiate benign from malignant lesions. There were 24 benign and 25 malignant tumours. Images were evaluated for the presence of low-signal septation, changes in pattern of homogeneity, signal intensity, and margin definition and shape. 20 of the 25 malignant tumours (80%) demonstrated low-signal septation, and two of the 24 benign tumours (8%) also demonstrated this feature. Malignant tumours tended to change pattern from being homogeneous on T1-weighted images to being heterogeneous on T2-weighted images (72%). Benign tumours maintained their pattern on both sequences (67%). Only three of the 24 benign tumours (12.5%) changed from being homogeneous to heterogeneous. Our findings suggest that tumours which change pattern, from homogeneous on T1-weighted images to heterogeneous on T2-weighted images, and tumours which have low-signal septations are likely to be malignant. Moreover benign lesions tend to have well defined margins, and some benign masses have characteristic appearances that aid in their differentiation from malignant processes.
authors.affiliation: Department of Radiology, Mount Sinai Medical Center, CUNY, NY 10029-6574.
authors.forename: G
authors.initials: G
authors.lastname: Hermann
authors.forename: I F
authors.initials: IF
authors.lastname: Abdelwahab
authors.forename: T T
authors.initials: TT
authors.lastname: Miller
authors.forename: M J
authors.initials: MJ
authors.lastname: Klein
authors.forename: M M
authors.initials: MM
authors.lastname: Lewis
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D005350:Fibroma / Q000175:diagnosis / Q000473:pathology; D018219:Histiocytoma, Benign Fibrous / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000473:pathology; D009135:Muscular Diseases / Q000175:diagnosis / Q000473:pathology; D012509:Sarcoma / Q000175:diagnosis / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000473:pathology; D013586:Synovitis, Pigmented Villonodular / Q000175:diagnosis