Delayed thermoregulatory changes in the immature rat following a single injection of ethanol.
Adult rats exhibit rebound hyperthermia within 24 hr following a single injection of ethanol (EtOH). Tests were conducted to determine whether similar changes in thermoregulatory ability occur in the immature rat. Animals were administered saline or EtOH (4 g/kg BW; intraperitoneally) at 2 to 3, 8 to 9, or 14 to 15 days of age. Littermates were handled or left undisturbed with the dams to serve as controls. All rats were tested at 24 or 48 hr post-treatment to measure steady-state colonic temperature (Tco), tail skin temperature and metabolic rate (MR) at both thermoneutral and cold ambient temperatures (Tas). The youngest group exhibited no delayed change in body temperature or MR at 24 or 48 hr post-treatment with EtOH. Likewise, thermoregulatory ability of rats pretreated with EtOH at 8 or 9 or 14 to 15 days of age was not significantly different from controls when tested 24 hr post-treatment at thermoneutral Ta. In contrast, Tco of EtOH-treated rats in the two older age groups was 1 degree C above control level when tested 24 hr post-treatment at cold Ta. This Tco response can be explained by differences in heat transfer to the tail and MR. No altered response to cold Ta was found at 48 hr postinjection, indicating recovery from the EtOH effect. A single injection with EtOH at 2 to 15 days of age results in a change in Tco, which is dependent on postinjection time, age, and Ta.
Spiers
D E
DE
John B. Pierce Laboratory, Inc., New Haven, Connecticut.
Fusco
L E
LE
D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000502:physiology; D000375:Aging / Q000502:physiology*; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects* / Q000502:physiology; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology; D000431:Ethanol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology
D011943:Receptors, Adrenergic, beta; D000431:Ethanol