title: The transplacental effect of lead compounds on inorganic pyrophosphatase in brain, liver and kidneys of newborn rats.
abstract: The transplacental effect of tetraethyl lead or lead acetate on the activity of inorganic pyrophosphatase in brain, liver and kidneys of newborn rats varied with the organ, the lead compound, the dose, and the route and time of administration. Enzyme activity was usually decreased in brain and liver, suggesting adverse effects of lead on metabolism in these organs. The inorganic pyrophosphatase activity was generally increased in kidneys.
authors.affiliation: Department of Biochemistry and Toxicology, Faculty of Veterinary Medicine, Aristotelian University, Thessaloniki, Greece.
authors.forename: F
authors.initials: F
authors.lastname: Tsafaris
authors.forename: E
authors.initials: E
authors.lastname: Alexaki
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000201:enzymology*; D007854:Lead / Q000008:administration & dosage / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011755:Pyrophosphatases / Q000032:analysis*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D007854:Lead; D011755:Pyrophosphatases