Multiple tumor suppressor genes in multistep carcinogenesis.
One of the most exciting areas of molecular oncology is the convergence of two independent lines of evidence suggesting involvement of multiple tumor suppressor genes in a given type of cancer. First, epidemiology and somatic cell genetics indicate the presence of multiple tumor suppressor genes in each of several malignancies. Second, cancers often lose multiple chromosomal regions during tumor progression. We will use two tumors, colorectal cancer and Wilms tumor, to illustrate the questions that multiple tumor suppressor genes raise.
Feinberg
A P
AP
Howard Hughes Medical Institute, University of Michigan, Ann Arbor.
Johnson
L A
LA
Law
D J
DJ
Kuehn
S E
SE
Steenman
M
M
Williams
B R
BR
Thomas
G
G
Boland
C R
CR
Rainier
S
S
Koi
M
M
D015179:Colorectal Neoplasms / Q000235:genetics*; D004273:DNA, Neoplasm / Q000378:metabolism; D017353:Gene Deletion; D016147:Genes, Tumor Suppressor; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D008745:Methylation; D009396:Wilms Tumor / Q000235:genetics*
D004273:DNA, Neoplasm