title: Magnetization transfer contrast (MTC) imaging of skeletal muscle at 0.26 Tesla--changes in signal intensity following exercise.
abstract: Magnetization transfer contrast (MTC) imaging of skeletal muscle before and after exercise has been studied in normal volunteers at 0.26 Tesla. A saturation pulse was applied over a range of offset frequencies immediately before a gradient recall echo sequence. Substantial signal loss was observed in all muscles. After exercise, selective saturation resulted in a significant increase of contrast between active and less active muscle, a phenomenon attributable to an increase in extracellular water content. MTC imaging provides a more sensitive method to detect changes in water distribution in human skeletal muscle.
authors.affiliation: Department of Diagnostic Radiology, University of Manchester.
authors.forename: X P
authors.initials: XP
authors.lastname: Zhu
authors.forename: S
authors.initials: S
authors.lastname: Zhao
authors.forename: I
authors.initials: I
authors.lastname: Isherwood
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology; D001834:Body Water; D001853:Bone Marrow / Q000033:anatomy & histology; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009132:Muscles / Q000033:anatomy & histology* / Q000502:physiology; D005082:Physical Exertion / Q000502:physiology*; D013848:Thigh