Determination of mitoxantrone by flow injection analysis using an amperometric detector.
Mitoxantrone was determined by flow injection analysis using a flow cell modified in the laboratory and fitted with carbon paste as an amperometric detector. The sample solution (100 microliters, 5 x 10(-8)-1 x 10(-5) M) was injected into the carrier stream of 0.1 M perchloric acid (pH 1.12). Mitoxantrone was determined by oxidation at the carbon paste electrode (CPE) at +0.90 V. A 60-cm delay coil (0.5 mm i.d.) was incorporated just before the detector (a canal thin layer) and a flow rate of about 4 ml min-1 was used. The system was successfully applied to the determination of mitoxantrone in a pharmaceutical preparation; the method was fast and reproducible.
Cortina Villar
J C
JC
Department of Physical and Analytical Chemistry, University of Oviedo, Principality of Asturias, Spain.
Costa García
A
A
Tuñón Blanco
P
P
D004566:Electrodes; D017022:Flow Injection Analysis / Q000379:methods*; D008942:Mitoxantrone / Q000032:analysis*; D010084:Oxidation-Reduction; D010472:Perchlorates / Q000737:chemistry; D015203:Reproducibility of Results
D010472:Perchlorates; D008942:Mitoxantrone