title: Giant cell carcinoma of the lung exhibiting a large, well-circumscribed photon deficiency in ventilation/perfusion scintigrams.
abstract: Giant cell carcinoma is a specific clinicopathological entity because of its fulminating clinical behavior and peripheral location in the lung. We present two patients with rapidly fatal giant cell carcinoma; each 99mTcMAA and/or 133Xe ventilation scintigrams showed a large, discrete, photon-deficient area in the lung. This unique scintigraphic finding may result from the peripheral location and rapid grawth of the giant cell tumor. Since giant cell carcinoma is a specific clinicopathological entity and of definite significance in establishing the prognosis of patients with lung cancer, 99mTcMAA and/or 133Xe scintigraphic findings may be useful in revealing such a tumor.
authors.affiliation: Nuclear Medicine Service, VAMC, Lexington, KY.
authors.forename: W J
authors.initials: WJ
authors.lastname: Shih
authors.forename: S
authors.initials: S
authors.lastname: Magoun
authors.forename: M
authors.initials: M
authors.lastname: Dillon
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000556:secondary; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011652:Pulmonary Circulation; D011827:Radiation; D011877:Radionuclide Imaging; D012119:Respiration; D013668:Technetium Tc 99m Aggregated Albumin; D014980:Xenon Radioisotopes
chemical_list: D013668:Technetium Tc 99m Aggregated Albumin; D014980:Xenon Radioisotopes