[Anti-polynuclear neutrophil cytoplasmic antibodies of the perinuclear type or p-ANCA].
Some neutrophil cytoplasmic auto-antibodies produce perinuclear immuno staining of alcohol-fixed neutrophils called P-Anca pattern. These autoantibodies show chiefly reactivity with myeloperoxidase in Elisa but other specificities have been detected (elastase, cathepsin, lactoferrin). These P-Anca anti-MPO are more frequent with renal angiitis but P-Anca (anti-MPO negative) are associated with other diseases without renal failure (rheumatoid arthritis, Gougerot-Sjogren and ulceritis colitis).
Oksman
F
F
Laboratoire d'Immunologie, CHU Purpan, Toulouse.
Soler
C
C
Goudable
C
C
Pourrat
J
J
Suc
J M
JM
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000032:analysis / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G; D007674:Kidney Diseases / Q000276:immunology*; D009195:Peroxidase / Q000276:immunology
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D001324:Autoantigens; D007074:Immunoglobulin G; D009195:Peroxidase
Les anticorps anti-cytoplasme des polynucléaires neutrophiles de type périnucléaire ou P-Anca.