Effect of synthetic enantiomeric cannabinoids on platelet aggregation.
The effect of a synthetic pair of enantiomeric cannabinoids on platelet function was evaluated. The nonpsychotropic enantiomer, the 1,1-dimethylheptyl homolog of (+)-(3S,4S)-7-hydroxy-delta-6-tetrahydrocannabinol (HU-211), was found to be more active in inhibiting ADP-induced platelet aggregation than the highly psychotropic (-)-enantiomer (HU-210). The related (+)-(3R,4R) cannabinoid, HU-213, which lacks the 7-hydroxy moiety, exerted its inhibitory effect within a wider range of concentrations. The results indicate a differentiation between psychotropic activity and inhibition of platelet aggregation in the cannabinoid group of compounds.
Nathan
I
I
Department of Clinical Biochemistry, Ben Gurion University of the Negev, Beer-Sheva, Israel.
Agam
G
G
Mechoulam
R
R
Dvilansky
A
A
Livne
A A
AA
D000244:Adenosine Diphosphate / Q000494:pharmacology; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D010976:Platelet Count; D013237:Stereoisomerism
D010975:Platelet Aggregation Inhibitors; C079455:HU 213; D000244:Adenosine Diphosphate; D013759:Dronabinol; C062018:HU 211