Principles of neuromuscular transmission.
Activation of skeletal muscles, small and large alike, occurs when spinal cord neurons send action potentials to groups of fibers. The central role of acetylcholine and its receptors in this activation is well established. The mechanisms involved and the implications for understanding neuromuscular disorders and for rationalizing and improving therapy are discussed.
Martin
A R
AR
Department of Physiology, University of Colorado School of Medicine, Denver.
D000109:Acetylcholine / Q000502:physiology; D000200:Action Potentials; D002118:Calcium / Q000502:physiology; D015220:Calcium Channels / Q000502:physiology; D006801:Humans; D009469:Neuromuscular Junction / Q000502:physiology*; D011978:Receptors, Nicotinic / Q000502:physiology; D013569:Synapses; D009435:Synaptic Transmission / Q000502:physiology*
D015220:Calcium Channels; D011978:Receptors, Nicotinic; D000109:Acetylcholine; D002118:Calcium