Studies on the plasma cholesterol and triacylglycerols in chronic methemoglobinemia in rats.
Plasma cholesterol and triacylglycerols were measured in rats with modelled chronic two-stage (mild and moderate) intermittent nitrite methemoglobinemia for 15 and 30 days. It was found that at the moment of methemoglobinemic peak (60 +/- 10 min) the experimental animals had mixed (hemtoxic, anemic and hypoxic) hypoxemia. The every day "pulse" decrease of the total oxygen concentration during the 30-day methemoglobinemia was accompanied with a significant rise (p < 0.05) of cholesterol concentrations in the high-density lipoproteins and the total cholesterol, as well as a decrease in the amount of triacylglycerols. These changes are considered to represent the side effects of adaptation for whose elucidation further research is needed.
Hristova
A
A
University of Medicine, Department of Pathophysiology, Plovdiv, Bulgaria.
Iluchev
D
D
Markova
V
V
Atanasov
N
N
D000818:Animals; D002784:Cholesterol / Q000097:blood; D002908:Chronic Disease; D004195:Disease Models, Animal; D008297:Male; D008708:Methemoglobinemia / Q000097:blood*; D010100:Oxygen / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
D014280:Triglycerides; D002784:Cholesterol; D010100:Oxygen