title: Heliotropium europaeum poisoning of sheep with low liver copper concentrations and the preventive efficacy of cobalt and antimethanogen.
abstract: In a field experiment in the Mallee district of Victoria, Merlno xBorder Leicester ewes and wethers grazed Heliotropium europaeum (heliotrope) over periods of 3 to 4 months in 4 successive years. By the end of the second year 12% (14 of 120) of the sheep had died; after 4 years the loss attributable to heliotrope was between 18% and 35%. Mortality was not affected by intraruminal treatment with cobalt or antimethanogen. At the end of the experiment the highest concentration of copper in the liver was 1.95 mmol/kg wet weight (approximately 413 micrograms/g dry weight). The relatively low mortality from primary heliotrope poisoning and the low concentration of copper in the liver of sheep grazing the plant are discussed in relation to the contrasting situation that prevails in the Riverina area of New South Wales. The importance of local environmental factors in the management of heliotrope grazing by sheep is emphasised, particularly in relation to the number of seasons in which the plant may be a major component of the diet.
authors.affiliation: CSIRO Division of Animal Health, Animal Health Research Laboratory, Parkville, Victoria.
authors.forename: J E
authors.initials: JE
authors.lastname: Peterson
authors.forename: A
authors.initials: A
authors.lastname: Payne
authors.forename: C C
authors.initials: CC
authors.lastname: Culvenor
mesh_terms: D000476:Alkanesulfonates / Q000627:therapeutic use*; D017738:Alkanesulfonic Acids; D000818:Animals; D001835:Body Weight; D003035:Cobalt / Q000627:therapeutic use*; D003300:Copper / Q000032:analysis; D005260:Female; D028162:Heliotropium; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000737:chemistry / Q000473:pathology; D008111:Liver Function Tests / Q000662:veterinary; D008297:Male; D010939:Plant Poisoning / Q000401:mortality / Q000517:prevention & control / Q000662:veterinary*; D006109:Poaceae / Q000737:chemistry; D012756:Sheep; D012757:Sheep Diseases / Q000401:mortality / Q000473:pathology / Q000517:prevention & control*
chemical_list: D000476:Alkanesulfonates; D017738:Alkanesulfonic Acids; C018853:2-bromoethanesulfonic acid; D003035:Cobalt; D003300:Copper