Thermogenesis, brown adipose tissue and dexfenfluramine in animal studies.
D-Fenfluramine is a potent stimulator of thermogenesis in the rat, an action which may contribute to its effects on body weight. The actions of D-fenfluramine appear to control release of endogenous 5-HT which subsequently induces release of eicosanoids and corticotrophin-releasing factor. Peripheral heat production results mainly from sympathetic activation of thermogenesis.
Rothwell
N J
NJ
Department of Physiological Sciences, University of Manchester, UK.
Le Feuvre
R A
RA
D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D001835:Body Weight; D004734:Energy Metabolism / Q000187:drug effects; D005277:Fenfluramine / Q000494:pharmacology*; D012701:Serotonin / Q000502:physiology
D005277:Fenfluramine; D012701:Serotonin