title: Virus-specific T cells in the central nervous system following infection with an avirulent neurotropic mouse hepatitis virus.
abstract: Intracerebral infection of mice with the neurotropic JHM strain of mouse hepatitis virus usually results in a fatal encephalomyelitis. However, infection with the neutralization resistant mutant, 2.2/7.2-V-2, results in inflammatory cell infiltration of the central nervous system with no apparent clinical symptoms, while conferring resistance to subsequent challenge with a lethal dose of wild type JHMV. The mononuclear cells infiltrating the brains of JHMV variant 2.2/7.2-V-2 infected mice were isolated and characterized. Virus-specific T cells which proliferated in response to JHMV antigen and produced both IL-2 and IFN-g were present among mononuclear cells infiltrating the brain as early as day 5 post-infection. The results suggest that the local immune response within the CNS may be important in dictating the outcome of disease following infections with neurotropic viruses.
authors.affiliation: Department of Neurology, University of Southern California School of Medicine, Los Angeles 90033.
authors.forename: J S
authors.initials: JS
authors.lastname: Williamson
mesh_terms: D000818:Animals; D000956:Antigens, Viral; D002490:Central Nervous System / Q000276:immunology / Q000473:pathology; D016207:Cytokines / Q000096:biosynthesis; D004679:Encephalomyelitis / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D014644:Genetic Variation; D006524:Hepatitis, Viral, Animal / Q000276:immunology* / Q000473:pathology; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D006517:Murine hepatitis virus / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D014774:Virulence
chemical_list: D000956:Antigens, Viral; D016207:Cytokines