title: Na+K+ATPase activity and ouabain binding sites in erythrocytes in hyperthyroidism before and after treatment.
abstract: Erythrocyte sodium pump is decreased in hyperthyroid patients. We described the effect of untreated hyperthyroidism on Na+K+ATPase activity, ouabain binding sites and intracellular sodium concentration. We found a reduction in Na+K+ATPase activity and in number of ouabain binding sites with a concomitant increase in intracellular sodium. B-blockade therapy failed to restore normal pump activity and sodium concentration, where only thionamide treatment was successful when it was able to decrease free T3.
authors.affiliation: Centro per le Malattie Endocrine e Metaboliche Ospedale Civile Umberto I, Mestre-Venezia, Italy.
authors.forename: C
authors.initials: C
authors.lastname: De Riva
authors.forename: S
authors.initials: S
authors.lastname: Chen
authors.forename: F
authors.initials: F
authors.lastname: Virgili
authors.forename: F
authors.initials: F
authors.lastname: Frigato
mesh_terms: D000328:Adult; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood* / Q000188:drug therapy / Q000201:enzymology; D008297:Male; D008713:Methimazole / Q000627:therapeutic use; D011188:Potassium / Q000097:blood; D011433:Propranolol / Q000627:therapeutic use; D011955:Receptors, Drug / Q000378:metabolism*; D012964:Sodium / Q000097:blood; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013960:Thyroid Function Tests
chemical_list: D011955:Receptors, Drug; C028996:cardiac glycoside receptors; D008713:Methimazole; D012964:Sodium; D011433:Propranolol; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium