Search for evidence of herpes simplex virus, type 1, or varicella-zoster virus infection in postmortem brain tissue from schizophrenic patients.
The highly sensitive polymerase chain reaction (PCR) was used to search for herpes simplex virus type 1 (HSV-I) or varicella-zoster virus (VZV) in the DNA extracted from postmortem temporal cortex samples of 8 schizophrenic subjects, 8 nonschizophrenic suicide victims and 8 normal controls. HSV-I or VZV-specific DNA amplification was not detected in any of the samples studied.
Alexander
R C
RC
Department of Psychiatry and Human Behavior, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107.
Cabirac
G
G
Lowenkopf
T
T
Casanova
M
M
Kleinman
J
J
Wyatt
R J
RJ
Kirch
D G
DG
D001483:Base Sequence; D005260:Female; D014645:Herpesvirus 3, Human / Q000276:immunology*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012559:Schizophrenia / Q000473:pathology*; D018139:Simplexvirus / Q000276:immunology*; D013405:Suicide; D013702:Temporal Lobe / Q000473:pathology*