title: Late-onset homozygous protein C deficiency manifesting cerebral infarction as the first symptom at age 27.
abstract: We report a 31-year-old female who had repeated thrombosis and was diagnosed as having congenital homozygous protein C deficiency based on decreased protein C antigen and activity, and the findings of family history. This patient had shown no symptom of thrombosis until the age of 27 years, when she had cerebral infarction as the first symptom. Low molecular weight heparin was useful for disseminated intravascular coagulation (DIC) that complicated protein C deficiency in this patient.
authors.affiliation: Mie University College of Medical Sciences, Tsu, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Deguchi
authors.forename: T
authors.initials: T
authors.lastname: Tsukada
authors.forename: E
authors.initials: E
authors.lastname: Iwasaki
authors.forename: H
authors.initials: H
authors.lastname: Wada
authors.forename: S
authors.initials: S
authors.lastname: Murashima
authors.forename: M
authors.initials: M
authors.lastname: Miyazaki
authors.forename: S
authors.initials: S
authors.lastname: Shirakawa
mesh_terms: D000328:Adult; D001778:Blood Coagulation Disorders / Q000150:complications / Q000235:genetics*; D001780:Blood Coagulation Tests; D002544:Cerebral Infarction / Q000209:etiology*; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy / Q000209:etiology; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use; D006801:Humans; D010375:Pedigree; D011486:Protein C / Q000235:genetics; D020151:Protein C Deficiency; D012008:Recurrence; D013927:Thrombosis / Q000209:etiology*
chemical_list: D006495:Heparin, Low-Molecular-Weight; D011486:Protein C