[Relation between emphysema and diaphragmatic fatigue].
Emphysematous rats induced by elastase were divided into 5 groups: N (control), P1 (elastase for 3 mo.), P2 (elastase for 4.5 mo.; NS intraperitoneally for 1 mo. after 3.5 mo. elastase); A and C, aminophylline and ginseng preparation were respectively given in the same fashion as P2. The results were: 1. tension and endurance of diaphragm muscle decreased under low frequency stimulation in P2, while those no change in P1. DNA, RNA and ATPase increased, cross-sectional areas and glycogen decreased in P1, while ATPase and RNA reduced with increase of cross-sectional areas in P2; 2. in A, no change in tension, with enhanced endurance; 3. in C, tension increased with no change in endurance; 4. glycogen and cross-sectional areas increased in both A and C; 5. RNA and ATPase increased in C and no change in A.
Gao
L
L
First Hospital, Beijing Medical University.
Mu
K
K
D000628:Aminophylline / Q000494:pharmacology*; D000818:Animals; D003964:Diaphragm / Q000187:drug effects / Q000503:physiopathology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D005894:Panax; D010196:Pancreatic Elastase; D010946:Plants, Medicinal; D011656:Pulmonary Emphysema / Q000139:chemically induced / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains
D004365:Drugs, Chinese Herbal; D000628:Aminophylline; D010196:Pancreatic Elastase