title: Increased detection of HPV 16 virus in invasive, but not in early cervical cancers.
abstract: Human papilloma virus type 16 (HPV 16) DNA is found in about 50% of cervical squamous cell carcinomas (SCCs), and this association has raised the possibility of a causal role for HPV 16 in cervical carcinogenesis. We have tested this hypothesis by assaying a series of biopsies (n = 119) ranging from normal mucosa to infiltrating SCC with the PCR-technique for the presence of HPV 16 DNA. While HPV 16 DNA was detected in 50% of our cases with invasive SCC, the incidence of HPV 16-positive samples was about 10% in all other biopsies ranging from normal mucosa to cases of carcinoma in situ. HPV 16 therefore appears to be involved in late tumor promotion but not in early tumor development.
authors.affiliation: Frauenklinik, Mannheim, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Labeit
authors.forename: W
authors.initials: W
authors.lastname: Back
authors.forename: F
authors.initials: F
authors.lastname: von Weizsäcker
authors.forename: P
authors.initials: P
authors.lastname: Hermann
authors.forename: F
authors.initials: F
authors.lastname: Melchert
authors.forename: K
authors.initials: K
authors.lastname: Leonard
authors.forename: S
authors.initials: S
authors.lastname: Labeit
mesh_terms: D001483:Base Sequence; D002278:Carcinoma in Situ / Q000382:microbiology; D002294:Carcinoma, Squamous Cell / Q000382:microbiology*; D015344:DNA Probes, HPV; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D006801:Humans; D008969:Molecular Sequence Data; D009361:Neoplasm Invasiveness; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D002583:Uterine Cervical Neoplasms / Q000382:microbiology*
chemical_list: D015344:DNA Probes, HPV; D004279:DNA, Viral