Association of the RTX proteins of Actinobacillus pleuropneumoniae with hemolytic, CAMP, and neutrophil-cytotoxic activities.
The immunoglobulin G from a monospecific rabbit antiserum to the 110-kDa RTX hemolysin of Actinobacillus pleuropneumoniae serotype 1 was used to determine that the related RTX proteins in isolates from serotypes 2 to 12 were also responsible for the hemolytic, CAMP, and neutrophil-cytotoxic activities produced by this bacterium. These proteins share common neutralizing epitopes.
Devenish
J
J
Toxinology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702-5011.
Brown
J E
JE
Rosendal
S
S
D016977:Actinobacillus pleuropneumoniae / Q000472:pathogenicity / Q000502:physiology*; D000818:Animals; D000242:Cyclic AMP / Q000032:analysis*; D006460:Hemolysin Proteins / Q000276:immunology / Q000633:toxicity*; D006461:Hemolysis / Q000187:drug effects*; D007074:Immunoglobulin G / Q000276:immunology; D009504:Neutrophils / Q000187:drug effects*; D011817:Rabbits; D012756:Sheep; D014774:Virulence
D006460:Hemolysin Proteins; D007074:Immunoglobulin G; D000242:Cyclic AMP