Identification of an African swine fever virus gene with similarity to a myeloid differentiation primary response gene and a neurovirulence-associated gene of herpes simplex virus.
Here we describe an open reading frame (LMW23-NL) in the African swine fever virus genome that possesses striking similarity to a murine myeloid differentiation primary response gene (MyD116) and the neurovirulence-associated gene (ICP34.5) of herpes simplex virus. In all three proteins, a centrally located acidic region precedes a highly conserved, hydrophilic 56-amino-acid domain located at the carboxy terminus. LMW23-NL predicts a highly basic protein of 184 amino acids with an estimated molecular mass of 21.3 kDa. The similarity of LMW23-NL to genes involved in myeloid cell differentiation and viral host range suggests a role for it in African swine fever virus host range.
Sussman
M D
MD
Plum Island Animal Disease Center, Agricultural Research Service, USDA, Greenport, New York 11944.
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Z
Kutish
G
G
Afonso
C L
CL
Roberts
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P
Rock
D L
DL
D000358:African Swine Fever Virus / Q000235:genetics* / Q000472:pathogenicity; D000595:Amino Acid Sequence; D000818:Animals; D000943:Antigens, Differentiation; D001483:Base Sequence; D005814:Genes, Viral; D016679:Genome, Viral; D008264:Macrophages / Q000382:microbiology; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics; D016364:Reading Frames; D012689:Sequence Homology, Nucleic Acid; D018139:Simplexvirus / Q000235:genetics; D013045:Species Specificity; D013552:Swine; D014764:Viral Proteins / Q000235:genetics*; D014774:Virulence
D000943:Antigens, Differentiation; D011506:Proteins; D014764:Viral Proteins; C066469:gamma 34.5 protein, Human herpesvirus 1; C076118:LMW23NL protein, African swine fever virus