[Intracranial hemodynamics in phenobarbital administration].
The effect of phenobarbital application on cerebral hemodynamics was studied in premature lambs. Near infrared spectroscopy was used for noninvasive monitoring of oxyhemoglobin, deoxyhemoglobin, total hemoglobin and cytochrom a/a3. Total intracranial blood volume decreased shortly after giving the drug and remained then on a stable lowered niveau. This could be explained with shifting of blood in different brain regions or with a decreased total intracranial blood volume.
Fahnenstich
H
H
Abteilung Neonatologie, Universität Bonn.
Schmidt
S
S
Krebs
D
D
Kowalewski
S
S
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000098:blood supply / Q000196:embryology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D003576:Electron Transport Complex IV / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006452:Hemoglobinometry; D010634:Phenobarbital / Q000494:pharmacology*; D011247:Pregnancy; D012756:Sheep
D003576:Electron Transport Complex IV; D010634:Phenobarbital
Intrakranielle Hämodynamik unter Phenobarbitalmedikation.