Neuroethological evaluation of audiogenic seizures and audiogenic-like seizures induced by microinjection of bicuculline into the inferior colliculus. II. Effects of nigral clobazam microinjections.
Male Wistar rats were classified as susceptible (S) and resistant (R) to audiogenic seizures (AS) by evaluation of their response to high-intensity sound stimulation (110.3 dB). R rats injected with bicuculline into the inferior colliculus (IC) preferentially displayed audiogenic-like seizures with gyri, jumping and atonic falling, without important tonic-clonic components but with postictal contralateral asymmetry and hyperreactivity. These audiogenic-like seizures were blocked by clobazam microinjection into the substantia nigra (SN) and partially modified by SN vehicle injection. Injection of vehicle or clobazam into the SN of susceptible rats (S) did not modify the occurrence of AS. This may suggest the participation of GABAergic regulation in the development of audiogenic-like seizures in R rats and a defect in GABAergic neurotransmission in S rats.
Terra
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VC
Department of Physiology, Ribeirão Preto School of Medicine, University of São Paulo, Brazil.
Garcia-Cairasco
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N
D000161:Acoustic Stimulation; D000818:Animals; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants / Q000494:pharmacology*; D001143:Arousal / Q000187:drug effects / Q000502:physiology; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology*; D001640:Bicuculline / Q000031:analogs & derivatives* / Q000494:pharmacology; D001931:Brain Mapping; D000078306:Clobazam; D004292:Dominance, Cerebral / Q000187:drug effects / Q000502:physiology; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced / Q000503:physiopathology*; D004924:Escape Reaction / Q000187:drug effects / Q000502:physiology; D007245:Inferior Colliculi / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D009434:Neural Pathways / Q000187:drug effects / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*; D013378:Substantia Nigra / Q000187:drug effects / Q000503:physiopathology*; D013477:Superior Colliculi / Q000187:drug effects / Q000503:physiopathology; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001570:Benzodiazepinones; D001569:Benzodiazepines; D000078306:Clobazam; C017069:bicuculline methiodide; D005680:gamma-Aminobutyric Acid; D001640:Bicuculline