Russell bodies consist of heterogenous glycoproteins in B-cell lymphoma cells.
The phenotypic expression of Russell bodies (RB) in the tumor cells of two patients with different types of B-cell lymphoma and of one patient with plasma cell myeloma were examined. In both B-cell lymphomas, the RBs reacted consistently with anti-Leu 8 and anti-immunoglobulin M. The RBs in one case also reacted with other monoclonal antibodies, including anti-CD5, CD19, CD22, and CD25. The membranes of most of the tumor cells containing RBs did not stain. In the myeloma, the RBs reacted only with anti-immunoglobulin, and the myeloma cells expressed no surface antigens associated with B lymphocytes. This finding suggests that RBs do not form in cells that can transport glycoproteins to the cell membrane, but rather occur as a result of defective transport or process of certain glycoproteins by plasmacytoid cells.
el-Okda
M
M
Department of Pathology, University of Arkansas for Medical Science, Little Rock.
Hyeh
Y
Y
Xie
S S
SS
Hsu
S M
SM
D000911:Antibodies, Monoclonal; D006023:Glycoproteins / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D002479:Inclusion Bodies / Q000737:chemistry*; D016393:Lymphoma, B-Cell / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D009101:Multiple Myeloma / Q000276:immunology / Q000473:pathology; D009363:Neoplasm Proteins / Q000032:analysis*
D000911:Antibodies, Monoclonal; D006023:Glycoproteins; D009363:Neoplasm Proteins