[Cytomegalovirus infections of the gastrointestinal tract].
Histopathological findings in 8 cases of CMV infections of the gastrointestinal tract including 5 cases with AIDS are presented. The cytomegalic cells were irregularly distributed and were predominantly found in esophagus, small bowel and colon. Viral inclusions were detected in "stromal" cells and in endothelial cells, sometimes associated with lesions of the vascular wall. Cytomegalic smooth muscle cells and glandular epithelia were also observed. No correlation was found between the number of cytomegalic cells per mm2 of tissue and the inflammatory response. Monoclonal CMV antibodies reacted immunohistologically not only with cytomegalic cells but also with a few normally appearing cells. The in-situ-hybridization detected CMV-DNA also in cells which were negative for CMV antigens. Notwithstanding the new immunohistological techniques the searching for cytomegalic cells and their recognition still belong to the most important steps required for the diagnosis of CMV infection.
Meybehm
M
M
Institut für Pathologie, Universität Bonn.
Kindermann
D
D
Bierhoff
E
E
D017088:AIDS-Related Opportunistic Infections / Q000473:pathology*; D001706:Biopsy; D003586:Cytomegalovirus Infections / Q000473:pathology*; D004730:Endothelium, Vascular / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005753:Gastric Mucosa / Q000098:blood supply / Q000473:pathology; D005759:Gastroenteritis / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure; D007413:Intestinal Mucosa / Q000098:blood supply / Q000473:pathology
Zytomegalieinfektionen im Gastrointestinaltrakt.