title: Dominant negative mutations in the Wilms tumour (WT1) gene cause Denys-Drash syndrome--proof that a tumour-suppressor gene plays a crucial role in normal genitourinary development.
authors.affiliation: MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK.
authors.forename: N D
authors.initials: ND
authors.lastname: Hastie
mesh_terms: D001483:Base Sequence; D002648:Child; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D005799:Genes, Dominant; D016162:Genes, Wilms Tumor; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics; D008969:Molecular Sequence Data; D013577:Syndrome; D014564:Urogenital Abnormalities; D014566:Urogenital System / Q000254:growth & development; D025721:WT1 Proteins; D009396:Wilms Tumor / Q000235:genetics
chemical_list: D004273:DNA, Neoplasm; D004268:DNA-Binding Proteins; D025721:WT1 Proteins