title: [Chronic consumption of brominated vegetable oils: their effect on liver secretion and catabolism of plasma lipoproteins].
abstract: We have previously reported that normal Wistar rats fed during 105 days with standard laboratory chow, supplemented with 0.5g of brominated vegetable oil (olive, sunflower) per 100 g of diet showed a significant increase of triglyceride and cholesterol content in both heart and liver. This was accompanied by a significant decrease of plasma lipid levels. Fluctuations in plasma triglyceride concentrations may be a result of either variations in the liver secretion rate of very low density lipoprotein-triglyceride (VLDL-TG), or changes in their removal rate by extrahepatic tissues or both. In the present work we have studied the contribution of both VLDL-TG secretion, and removal rates of plasma TG in the decrease of plasma TG levels, in rats fed during 105 days with a standard laboratory chow supplemented with 0.5 g per 100 g of brominated vegetable oil. VLDL-TG secretion was estimated by measuring the accumulation of plasma TG following the injection of TRITON WR 1339 and the removal rate of plasma TG by assaying plasma post-heparin lipolytic total (PHLA) and hepatic (H-TGL) lipase activities. In addition, the major lipid composition of plasma lipoprotein fractions were measured. Results were compared to those of a control group fed a laboratory chow diet during the same period of time. Our results show a decrease in both VLDL-TG secretion and plasma TG pool size accompanied by normal PHLA and H-TGL activities in animals fed the diet supplemented with brominated oils. However, the proportion of the major lipid components of the plasma lipoproteins fractions were unchanged.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
authors.forename: N O
authors.initials: NO
authors.lastname: Mocchiutti
authors.forename: C A
authors.initials: CA
authors.lastname: Bernal
authors.forename: Y B
authors.initials: YB
authors.lastname: Lombardo
mesh_terms: D000818:Animals; D001628:Beverages; D001966:Bromine; D005503:Food Additives / Q000633:toxicity*; D006321:Heart / Q000187:drug effects; D008049:Lipase / Q000032:analysis; D008055:Lipids / Q000097:blood; D008066:Lipolysis; D008074:Lipoproteins / Q000097:blood*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010938:Plant Oils / Q000737:chemistry / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D012636:Secretory Rate; D014280:Triglycerides / Q000378:metabolism*
chemical_list: D005503:Food Additives; D008055:Lipids; D008074:Lipoproteins; D010938:Plant Oils; D014280:Triglycerides; D008049:Lipase; D001966:Bromine
vernacular_title: Ingesta crónica de aceites vegetales bromados: su acción sobre la secreción hepática y catabolismo de lipoproteínas plasmáticas.