Amino acids and cholesterol levels of leukemic lymphocytes infected with bovine leukemia virus (BLV).
We performed qualitative and quantitative amino acids analysis of lymphocytes from normal and leukemic cattle (infected with bovine leukemia virus) to determine cellular cholesterol levels. Leukemic lymphocytes exhibited quantitative differences in the levels of some "glycogenic", "ketogenic" and "glyco-ketogenic" amino acids. These differences may reflect the disturbances of Krebs cycle. Evidence was produced that increased cholesterol content in the above lymphocytes was associated with disorders in beta-oxidation processes of leukemic cells.
Madej
J A
JA
Department of Pathological Anatomy and Forensic Veterinary, Agricultural University, Wrocław, Poland.
Klimentowski
S
S
Miskiewicz
J
J
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D002784:Cholesterol / Q000378:metabolism*; D001909:Leukemia Virus, Bovine / Q000378:metabolism*; D007942:Leukemia, Experimental / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism* / Q000382:microbiology*
D000596:Amino Acids; D002784:Cholesterol