Immunoregulatory mechanisms and Chagas' disease.
During the course of experimental Chagas' disease, several immune disorders occur. In the acute phase, T and B cell polyclonal activation is associated to immunosuppression. At the chronic stage, T cells--of the TH2 subset--participate to the pathology characteristic of Chagas' disease. Data obtained after infection of BALB/Xid mice suggest that polyclonal activation may be dependent on B1 (CD5) cell-activation. Moreover, these mice fail to develop the pathological features of the chronic infection. Control of lymphokine secretion might play a key role in the clinical status of Chagas' disease.
Hontebeyrie-Joskowicz
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Unité d'Immunoparasitologie, Institut Pasteur, Paris, France.
D000208:Acute Disease; D000818:Animals; D002598:Chagas Cardiomyopathy / Q000401:mortality; D014355:Chagas Disease / Q000150:complications / Q000276:immunology*; D002908:Chronic Disease; D016757:Death, Sudden, Cardiac / Q000453:epidemiology; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000276:immunology; D008213:Lymphocyte Activation; D016131:Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D008222:Lymphokines / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D009000:Monocytes / Q000276:immunology
D008222:Lymphokines