title: Role of amino acid residue 187 of poliovirus polypeptide 2C in determining the guanidine trait.
abstract: Although mutations in codons 164 and 179 of poliovirus polypeptide 2C can establish guanidine resistance, the majority of guanidine-resistant and guanidine-dependent viruses contain an M----L change at amino residue 187 along with other critical mutations. The change at residue 187 probably contributes to the guanidine phenotype along with a variety of other modifications in polypeptide 2C, possibly altering conformation of the polypeptide during the initiation step of viral RNA synthesis.
authors.affiliation: Department of Molecular and Cell Biology, Pennsylvania State University, University Park 16802.
authors.forename: R F
authors.initials: RF
authors.lastname: Baltera
authors.forename: D R
authors.initials: DR
authors.lastname: Tershak
mesh_terms: D000596:Amino Acids / Q000502:physiology; D001483:Base Sequence; D002352:Carrier Proteins; D005814:Genes, Viral / Q000235:genetics; D019791:Guanidine; D006146:Guanidines / Q000494:pharmacology*; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics; D010641:Phenotype; D017955:Poliovirus / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D017361:Viral Nonstructural Proteins; D014764:Viral Proteins / Q000737:chemistry* / Q000235:genetics / Q000502:physiology
chemical_list: D000596:Amino Acids; D002352:Carrier Proteins; D006146:Guanidines; D017361:Viral Nonstructural Proteins; D014764:Viral Proteins; C076023:2C protein, viral; D019791:Guanidine