Two TNF receptors.
In the past few years, considerable progress has been made on the identification and characterization of tumor necrosis factor (TNF) receptors. The relative roles played by the two receptor types in signaling the diverse functions of TNF are less clear. Here, Louis Tartaglia and David Goeddel summarize progress to date and propose a model of TNF receptor triggering that reconciles the seemingly conflicting data.
Tartaglia
L A
LA
Genentech, South San Francisco, CA 94080.
Goeddel
D V
DV
D000818:Animals; D000906:Antibodies / Q000276:immunology; D002460:Cell Line; D003001:Cloning, Molecular; D005796:Genes; D006801:Humans; D051379:Mice; D008954:Models, Biological; D008970:Molecular Weight; D011940:Receptor Aggregation; D011956:Receptors, Cell Surface / Q000145:classification* / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification / Q000502:physiology; D018124:Receptors, Tumor Necrosis Factor; D012689:Sequence Homology, Nucleic Acid; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha
D000906:Antibodies; D011956:Receptors, Cell Surface; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha