[Mechanism of vitamin B6 regulation of acetylcholine-induced currents in mollusk neurons: pre- and postsynaptic effects].
Vitamin B6 has been studied for the mechanism of its effect on acetylcholine-induced sodium-potassium and chloride currents in E16 neuron of isolated brain of the snail Helix pomatia. The results indicate that the effect of vitamin B6 on acetylcholine-induced currents in postsynaptic neuron E16 is mediated via changes in gamma-aminobutyric acid (GABA) release from a presynaptic neuron and subsequent GABA-induced and cAMP-dependent processes in E16 neuron. It is suggested that effects of vitamin and antivitamin B6 on axons of a presynaptic neuron or neurons may be connected with regulation of GABA synthesis from glutamate catalyzed by the pyridoxal-phosphate-containing enzyme.
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D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D018118:Chloride Channels; D002712:Chlorides; D005968:Glutamate Decarboxylase / Q000037:antagonists & inhibitors; D006372:Helix, Snails / Q000187:drug effects*; D066298:In Vitro Techniques; D008565:Membrane Proteins / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D015221:Potassium Channels / Q000187:drug effects; D011736:Pyridoxine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011950:Receptors, Cholinergic / Q000187:drug effects; D015222:Sodium Channels / Q000187:drug effects; D013569:Synapses / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D018118:Chloride Channels; D002712:Chlorides; D008565:Membrane Proteins; D015221:Potassium Channels; D011950:Receptors, Cholinergic; D015222:Sodium Channels; D005680:gamma-Aminobutyric Acid; D005968:Glutamate Decarboxylase; D011736:Pyridoxine; D000109:Acetylcholine; D001640:Bicuculline
Mekhanizm reguliatsii vitaminom B6 atsetilkholinindutsiruemykh tokov v neĭronakh molliuska: pre- i postsinapticheskie éffekty.