Gastroduodenal polyps in familial adenomatous polyposis.
A retrospective review of the medical records of 30 patients with familial adenomatous polyposis who underwent oesophagogastroduodenoscopy was performed to evaluate the spectrum of gastroduodenal polyps. Twenty-five patients (83%) had gastroduodenal polyps. Eighteen patients (60%) had gastric polyps and 21 patients (70%) had duodenal polyps. Five patients (17%) had gastric and 20 patients (67%) had duodenal adenomatous polyps. Three patients (10%) died from an upper gastrointestinal tract adenocarcinoma. Three of nine patients with periampullary adenomas had a normal-appearing papilla of Vater. Since gastroduodenal polyps are common in familial adenomatous polyposis, oesophagogastroduodenoscopy should be performed at the time of diagnosis. Biopsy of polyps as well as biopsy of a normal-appearing papilla of Vater should be performed. Due to their malignant potential, if identified, gastroduodenal adenomatous polyps should be destroyed.
Goedde
T A
TA
Roswell Park Cancer Institute, Department of Surgical Oncology, Buffalo, New York 14263.
Rodriguez-Bigas
M A
MA
Herrera
L
L
Petrelli
N J
NJ
D011125:Adenomatous Polyposis Coli / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D000293:Adolescent; D000328:Adult; D002648:Child; D004379:Duodenal Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D016145:Endoscopy, Digestive System; D005260:Female; D006801:Humans; D007417:Intestinal Polyps / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009518:New York / Q000453:epidemiology; D011127:Polyps / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality