Nucleotide sequence of endothelin-1 cDNA from rabbit endothelial cells.
A cDNA encoding rabbit endothelin-1 (ET-1) was isolated by plaque hybridization from a rabbit inferior vena caval endothelial cell lambda gt11 cDNA library using human ET-1 cDNA as the hybridization probe. DNA sequence analysis indicates that mature 21 amino acid rabbit ET-1 is derived from a 202 amino acid precursor, via a 39 amino acid intermediate 'big' ET-1.
Marsden
P A
PA
Department of Medicine, St. Michael's Hospital, Toronto, Canada.
Sultan
P
P
Cybulsky
M
M
Gimbrone
M A
MA
Brenner
B M
BM
Collins
T
T
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004247:DNA; D019332:Endothelin-1; D016232:Endothelins / Q000737:chemistry / Q000235:genetics*; D004730:Endothelium, Vascular / Q000737:chemistry*; D008969:Molecular Sequence Data; D011498:Protein Precursors / Q000737:chemistry / Q000235:genetics; D011817:Rabbits; D012689:Sequence Homology, Nucleic Acid
D019332:Endothelin-1; D016232:Endothelins; D011498:Protein Precursors; D004247:DNA