IgG and IgA antibody responses against porins in Yersinia-triggered reactive arthritis.
Using an enzyme immunoassay, the development and persistence of serum IgG and IgA class antibody responses against porins, a class of the major outer membrane proteins, were compared between patients who developed reactive arthritis and subjects who did not after Yersinia infection. A significant difference was seen between the two patient groups in the beginning of the disease: those with reactive arthritis had higher levels of IgG and IgA class antibodies against the porins. A similar difference in the IgA class antibodies was also seen at follow-up. This supports the hypothesis of persistence of the pathogen within the arthritic host.
Mäki-Ikola
O
O
National Public Health Institute, Turku, Finland.
Hill
J L
JL
Lahesmaa
R
R
Toivanen
A
A
Granfors
K
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D000917:Antibody Formation; D016918:Arthritis, Reactive / Q000097:blood / Q000209:etiology / Q000276:immunology*; D001425:Bacterial Outer Membrane Proteins / Q000032:analysis / Q000276:immunology*; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D018272:Porins; D015009:Yersinia Infections / Q000150:complications / Q000276:immunology*; D015008:Yersinia enterocolitica / Q000737:chemistry* / Q000502:physiology / Q000648:ultrastructure
D001425:Bacterial Outer Membrane Proteins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D018272:Porins