[Experimental studies on the antitumor activity of glioma-infiltrating lymphocytes against autologous glioma].
In the present study, antitumor activity of glioma-infiltrating lymphocytes (GILs) was compared to that of lymphokine-activated killer (LAK) cells. Results suggested that killing activity of GILs against autologous glioma cells was significantly higher than that of LAK cells (P less than 0.05), but their activity against allogeneic glioma cells was not different from that of LAK cells (P greater than 0.05). Analysis of cell surface phenotypes showed that CD4+ cells were a main portion of LAK cells, and CD8+ were predominant in the GILs. In the beginning, growth of GILs was slower than that of LAK cells. As time went on, generation of GILs was faster than that of LAK cells. The results suggested that GILs were superior to LAK cells for adoptive immunotherapy in patients with brain glioma.
Li
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Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai.
D001932:Brain Neoplasms / Q000473:pathology* / Q000628:therapy; D016516:CD4-CD8 Ratio; D002478:Cells, Cultured; D005909:Glioblastoma / Q000473:pathology* / Q000628:therapy; D006801:Humans; D016219:Immunotherapy, Adoptive; D015979:Killer Cells, Lymphokine-Activated / Q000166:cytology / Q000276:immunology; D016246:Lymphocytes, Tumor-Infiltrating / Q000166:cytology / Q000276:immunology*; D014407:Tumor Cells, Cultured