Concentrations of antibiotics in alveolar milk after intramammary inlocation of their different doses together with glucose, acetylsalicylic acid or chlormethine.
After intramammary introduction of penicillin (600 th. i.u.), streptomycin (0.5 g), cloxacillin (0.5 g), neomycin (0.5 g), erythromycin (0.5 g) and cefoperazone (0.25 g) in 100 ml of 5% glucose solution the antibiotics' concentrations in the alveolar milk remained for 24 hours or longer on the level higher than MIC in relation to staphylococci and streptococci isolated from cows mastitis. In the first 24 hours the growth of antibiotic activity was little influenced by chlormethine supplement. While addition of ASA increased concentration and prolonged the time of antibiotics remaining on the therapeutic level.
Malinowski
E
E
Department of Phsiopathology of Reproduction and Mammary Gland, National Veterinary Research Institute, Poland.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology*; D002417:Cattle; D005260:Female; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology*; D007263:Infusions, Parenteral; D007700:Kinetics; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000502:physiology*; D008466:Mechlorethamine / Q000008:administration & dosage / Q000494:pharmacology*; D008892:Milk / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D008466:Mechlorethamine; D005947:Glucose; D001241:Aspirin