title: Chronic intestinal pseudoobstruction in a patient with heart-lung transplant. Therapeutic effect of leuprolide acetate.
abstract: After orthotopic heart-lung transplantation and immunosuppression, a patient developed intractable nausea and vomiting in association with chronic cytomegalovirus infection. Chronic intestinal pseudoobstruction was documented by antroduodenal manometric study. The patient was treated with leuprolide acetate with resolution of symptoms and improvement of intestinal motility abnormality. This case demonstrates an association of chronic viral infection with acquired intestinal motor disorders. Gastrointestinal complications that are common after organ transplantation might be due to acquired neuromuscular disease. The potential efficacy of leuprolide in such neuromuscular disorders provides a rationale for diagnostic motility studies in patients with "functional" gastrointestinal disorders.
authors.affiliation: Department of Internal Medicine, University of Texas Medical Branch, Galveston 77550-2780.
authors.forename: J R
authors.initials: JR
authors.lastname: Mathias
authors.forename: G S
authors.initials: GS
authors.lastname: Baskin
authors.forename: V G
authors.initials: VG
authors.lastname: Reeves-Darby
authors.forename: M H
authors.initials: MH
authors.lastname: Clench
authors.forename: L L
authors.initials: LL
authors.lastname: Smith
authors.forename: J H
authors.initials: JH
authors.lastname: Calhoon
mesh_terms: D000293:Adolescent; D002908:Chronic Disease; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects; D016041:Heart-Lung Transplantation; D006801:Humans; D007165:Immunosuppression Therapy; D007418:Intestinal Pseudo-Obstruction / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D007421:Intestine, Small; D016729:Leuprolide / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D012008:Recurrence; D014766:Viremia / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D016729:Leuprolide