Effect of anthelmintics on phosphatases in Ascaridia galli.
In vitro addition of the drugs tetramisole (TMS) and levamisole (LMS) caused an inhibition of the specific activities of acid phosphatase and Mg(++)-dependent adenosine triphosphatase. The inhibition was non-competitive in nature. No significant inhibition was caused by TMS in the activity of glucose-6-phosphatase, but LMS inhibited the enzyme in a non-competitive manner. The activity of alkaline phosphatase was, however, increased in the presence of both TMS and LMS.
Aggarwal
R
R
Department of Zoology, Panjab University, Chandigarh, India.
Sanyal
S N
SN
Khera
S
S
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D001197:Ascaridia / Q000187:drug effects / Q000201:enzymology*; D010744:Phosphoric Monoester Hydrolases / Q000187:drug effects* / Q000378:metabolism
D000871:Anthelmintics; D010744:Phosphoric Monoester Hydrolases