Inositol hexakisphosphate receptor identified as the clathrin assembly protein AP-2.
To clarify the function of the receptor binding protein for inositol hexakisphosphate (IP6), we obtained a partial amino acid sequence from the purified protein and a partial nucleotide sequence from a cDNA clone of the gene. The sequences are essentially identical to those of the alpha-subunit of the clathrin assembly protein AP-2. The IP6 receptor protein analyzed by SDS-PAGE contains a series of subunits which are the same as those of AP-2. Antibodies to AP-2 react with the IP6 receptor protein in immunoblot analysis.
Voglmaier
S M
SM
Johns Hopkins University School of Medicine, Department of Neuroscience, Baltimore, MD 21205.
Keen
J H
JH
Murphy
J E
JE
Ferris
C D
CD
Prestwich
G D
GD
Snyder
S H
SH
Theibert
A B
AB
D033942:Adaptor Proteins, Vesicular Transport; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000648:ultrastructure; D002417:Cattle; D003034:Coated Pits, Cell-Membrane / Q000737:chemistry; D004247:DNA / Q000737:chemistry; D004591:Electrophoresis, Polyacrylamide Gel; D051379:Mice; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry; D010750:Phosphoproteins / Q000737:chemistry*; D016133:Polymerase Chain Reaction; D051381:Rats; D011956:Receptors, Cell Surface / Q000737:chemistry* / Q000235:genetics; D018160:Receptors, Cytoplasmic and Nuclear; D012689:Sequence Homology, Nucleic Acid
D033942:Adaptor Proteins, Vesicular Transport; D010446:Peptide Fragments; D010750:Phosphoproteins; D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; C068271:inositol hexakisphosphate receptor; D004247:DNA