Long term kappa-opioid receptor blockade following nor-binaltorphimine.
This study determined the influence of nor-binaltorphimine (nor-BNI, 10 micrograms intracisternally), 1, 7 and 21 days post-administration, upon spiradoline-induced antinociception measured in the hot-plate test. On each test day, nor-BNI prevented the spiradoline-induced increase in the latency of rats to paw-lick without affecting the antinociceptive response to morphine. These data suggest that a single administration of nor-BNI can cause a long term blockade of kappa-opioid receptors in rats.
Jones
D N
DN
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322.
Holtzman
S G
SG
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D008297:Male; D009271:Naltrexone / Q000031:analogs & derivatives* / Q000494:pharmacology; D010147:Pain Measurement; D011759:Pyrrolidines / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000187:drug effects; D017473:Receptors, Opioid, kappa / Q000037:antagonists & inhibitors*
D000700:Analgesics; D011759:Pyrrolidines; D017473:Receptors, Opioid, kappa; C051844:norbinaltorphimine; D009271:Naltrexone; C051272:spiradoline