title: The colorectal cancer gene hunt: current findings.
abstract: Identification of four genes, each with its own clinical significance, promises probes for early diagnosis of colorectal cancer in the near future. It also suggests possibilities for new forms of chemotherapy to offset the effects of mutated or lost genes. Given the "moving target" of metastasis, this is likely to be a more fruitful approach than gene replacement--and a more immediate one.
authors.affiliation: Johns Hopkins University.
authors.forename: K W
authors.initials: KW
authors.lastname: Kinzler
authors.forename: B
authors.initials: B
authors.lastname: Vogelstein
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000235:genetics; D000970:Antineoplastic Agents / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D017491:Genes, APC / Q000235:genetics; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D008957:Models, Genetic; D009154:Mutation
chemical_list: D000970:Antineoplastic Agents