[The enhancement of the efficacy of adriamycin by using hepatoprotectors of plant origin in metastases of Ehrlich's adenocarcinoma to the liver in mice].
It was shown that the use of an anthracycline antibiotic--adriamycin in mice with metastatic involvement resulted in pronounced liver dysfunction, as suggested by a sharp increase in blood transaminase levels. In the same model, a hepatoprotector of plant origin--Rhodiola rosea extract--was shown to inhibit tumor dissemination. Combined application of adriamycin and the extract proved no inferior in terms of antimetastatic efficacy and nearly free from toxicity.
Udintsev
S N
SN
Krylova
S G
SG
Fomina
T I
TI
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D004317:Doxorubicin / Q000627:therapeutic use*; D004354:Drug Screening Assays, Antitumor; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental; D010936:Plant Extracts / Q000627:therapeutic use*
D010936:Plant Extracts; D004317:Doxorubicin
Povshenie éffektivnosti adriamitsina s pomoshch'iu gepatoprotektorov rastitel'nogo proiskhozhdeniia pri metastazakh adenokartsinomy Erlikha v pechen' u mysheĭ.