Mechanisms of platelet adhesion and aggregation: an update.
A hemostatic plug is initially composed of an adherent layer of platelets, but it is subsequent platelet aggregation that stems the flow of leaking blood. Unlike platelet adhesion--which is a passive process--platelet aggregation is active, requiring ongoing platelet metabolism and stimulation by one or more specific agonists.
Bennett
J S
JS
University of Pennsylvania, Philadelphia.
D005340:Fibrinogen / Q000502:physiology; D006023:Glycoproteins / Q000187:drug effects / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000502:physiology; D010973:Platelet Adhesiveness / Q000187:drug effects / Q000502:physiology*; D010974:Platelet Aggregation / Q000187:drug effects / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000502:physiology; D013915:Thrombasthenia / Q000097:blood; D014842:von Willebrand Diseases / Q000097:blood; D014841:von Willebrand Factor / Q000502:physiology
D006023:Glycoproteins; D016023:Integrins; D011956:Receptors, Cell Surface; D014841:von Willebrand Factor; D005340:Fibrinogen