title: Susceptibility of Rickettsia conorii, R. rickettsii, and Coxiella burnetii to PD 127,391, PD 131,628, pefloxacin, ofloxacin, and ciprofloxacin.
abstract: Plaque formation and dye uptake assays were used to measure the MICs of PD 127,391 and PD 131,628 against Rickettsia species. The MICs of PD 127,391 were 0.25 microgram/ml for Rickettsia rickettsii and 0.125 to 0.25 microgram/ml for Rickettsia conorii. The MICs of PD 131,628 were 0.25 to 0.5 microgram/ml for R. rickettsii and 0.5 microgram/ml for R. conorii. As determined by the shell vial technique, 15 strains of Coxiella burnetii were susceptible to PD 127,391 and PD 131,628 (MIC, < or = 1 microgram/ml), while one strain of C. burnetii (MP10) was of intermediate susceptibility.
authors.affiliation: Unité des Rickettsies, Faculté de Médecine, Marseille, France.
authors.forename: N
authors.initials: N
authors.lastname: Jabarit-Aldighieri
authors.forename: H
authors.initials: H
authors.lastname: Torres
authors.forename: D
authors.initials: D
authors.lastname: Raoult
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D016997:Coxiella burnetii / Q000187:drug effects*; D024841:Fluoroquinolones; D008826:Microbial Sensitivity Tests; D009287:Naphthyridines; D015242:Ofloxacin / Q000494:pharmacology; D015366:Pefloxacin / Q000494:pharmacology; D015363:Quinolones / Q000494:pharmacology; D012281:Rickettsia / Q000187:drug effects*; D012284:Rickettsia rickettsii / Q000187:drug effects*; D010948:Viral Plaque Assay
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; D015363:Quinolones; C068217:PD 131628; D015366:Pefloxacin; D002939:Ciprofloxacin; C057477:clinafloxacin; D015242:Ofloxacin