[The mechanisms of the effect of serotonin on the prostacyclin synthesis and coronary vascular resistance of the isolated rat heart].
An early reduction of coronary vascular resistance after serotonin administration was found to be due to the activity of prostacyclin synthesis and an endothelial-relaxing factor in the rat isolated heart. The activating effect of serotonin on the prostacyclin synthesis was inhibited by catanserin and dyltyasem. The latters prevented damage of endotheliocytes and the beginning of a vasal constriction caused by the protracted serotonin action.
Gereliuk
I P
IP
Stukal
I K
IK
D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects* / Q000502:physiology; D011464:Epoprostenol / Q000032:analysis / Q000096:biosynthesis*; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D008833:Microcirculation / Q000187:drug effects / Q000648:ultrastructure; D008854:Microscopy, Electron; D009206:Myocardium / Q000648:ultrastructure; D010477:Perfusion / Q000379:methods; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects* / Q000502:physiology
D012701:Serotonin; D011464:Epoprostenol
O mekhanizmakh vliianiia serotonina na sintez prostatsiklina i koronarnoe sosudistoe soprotivlenie izolirovannogo serdtsa krys.