Effect of folate on cervical cancer. Synergism among risk factors.
Folate deficiency appears to play a crucial role early in cervical carcinogenesis by facilitating the incorporation of HPV genomes at a fragile chromosomal site. Thereafter, multiple nutritional, hormonal, and immunologic factors probably interact in a synergistic manner to determine whether the cell line becomes immortalized and invasive.
Butterworth
C E
CE
Department of Nutrition Sciences, University of Alabama, Birmingham 35294-3360.
D005260:Female; D005492:Folic Acid / Q000378:metabolism*; D005494:Folic Acid Deficiency / Q000503:physiopathology*; D016147:Genes, Tumor Suppressor; D006801:Humans; D009857:Oncogenes; D027383:Papillomaviridae / Q000235:genetics; D012307:Risk Factors; D002578:Uterine Cervical Dysplasia / Q000382:microbiology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000209:etiology* / Q000235:genetics / Q000382:microbiology
D005492:Folic Acid