Effects of human HSS on hepatocyte and hepatoma cell proliferation and D-GAL induced acute liver failure.
Human hepatic stimulator substance (HSS), an organ-specific and heat-stable factor which differs from insulin, glucagon and EGF, has been partially purified from aborted human fetal livers. It was found to stimulate DNA synthesis of human hepatocytes. AH22 hepatoma cells responded dose-dependently. HSS was also found to enhance the survival of D-GAL intoxicated rats as compared to control (62.5% vs. 26.1%). Our results suggest that human HSS is very similar to that in animals.
Zhou
Z
Z
Department of Biochemistry, Cancer Institute, CAMS, Beijing.
Tan
R
R
Su
S
S
Zhou
C
C
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D005333:Fetus; D005690:Galactose; D006133:Growth Substances / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D008099:Liver / Q000737:chemistry / Q000166:cytology*; D017114:Liver Failure, Acute / Q000139:chemically induced / Q000517:prevention & control*; D008113:Liver Neoplasms / Q000473:pathology*; D008115:Liver Regeneration; D051381:Rats; D014407:Tumor Cells, Cultured / Q000187:drug effects
D006133:Growth Substances; D005690:Galactose