[The content of sex steroid receptors and the activity of marker enzymes of estrogenic action in the uterus of androgen-sterile rats].
In rats with preserved ovaries, both in normal and in neonatally androgenized, the activity of enzymes kreatinphosphokinase and peroxidase cannot serve as the marker of the estradiol effect upon the uterus. In ovariectomised animals, the dynamics of activity of these enzymes corresponds to uterotropic responses to estradiol. but not to the dynamics of hormone receptor complexes. The data obtained makes doubtful the participation of the hormone receptor complexes in realisation of the estrogens effect upon the uterus.
Arutiunian
N A
NA
Savchenko
O N
ON
Proĭmina
F I
FI
Sekretareva
E V
EV
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D003402:Creatine Kinase / Q000032:analysis / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D007247:Infertility, Female / Q000139:chemically induced / Q000201:enzymology*; D010052:Ovariectomy; D009195:Peroxidase / Q000032:analysis / Q000187:drug effects*; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D011959:Receptors, Estradiol / Q000032:analysis / Q000187:drug effects*; D011980:Receptors, Progesterone / Q000032:analysis / Q000187:drug effects*; D013739:Testosterone / Q000494:pharmacology*; D014599:Uterus / Q000187:drug effects* / Q000201:enzymology
D015415:Biomarkers; D011959:Receptors, Estradiol; D011980:Receptors, Progesterone; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D009195:Peroxidase; D003402:Creatine Kinase
Soderzhanie retseptorov polovykh steroidov i aktivnost' nekotorykh fermentov-markerov éstrogennogo deĭstviia v matke u androgensteril'nykh krys.