title: Determination of cathepsins B, H, L and kininogen in breast cancer patients.
abstract: In 20 matched pairs, an increase of all cathepsins was measured in carcinoma tissue compared with normal tissue of the same breast. On contrary, the mean value for kininogen was almost 2 fold lower than mean value determined in normal cytosols. From all proteins tested, the amount of cathepsin B correlated mostly with the degree of malignancy inside the group of invasive ductal carcinoma (n = 90, p < 0.01).
authors.affiliation: Dept. of Biochemistry, Jozef Stefan Institute, Ljubljana, Slovenia.
authors.forename: D
authors.initials: D
authors.lastname: Gabrijelcic
authors.forename: B
authors.initials: B
authors.lastname: Svetic
authors.forename: D
authors.initials: D
authors.lastname: Spaić
authors.forename: J
authors.initials: J
authors.lastname: Skrk
authors.forename: J
authors.initials: J
authors.lastname: Budihna
authors.forename: V
authors.initials: V
authors.lastname: Turk
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D002401:Cathepsin B / Q000032:analysis / Q000378:metabolism*; D056655:Cathepsin H; D056668:Cathepsin L; D002403:Cathepsins / Q000032:analysis / Q000378:metabolism*; D003546:Cysteine Endopeptidases; D003600:Cytosol / Q000201:enzymology / Q000378:metabolism; D010450:Endopeptidases; D005260:Female; D006801:Humans; D007704:Kininogens / Q000032:analysis / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D012016:Reference Values
chemical_list: D014408:Biomarkers, Tumor; D007704:Kininogens; D002403:Cathepsins; D010450:Endopeptidases; D003546:Cysteine Endopeptidases; D002401:Cathepsin B; C534281:CTSL protein, human; D056668:Cathepsin L; C534126:CTSH protein, human; D056655:Cathepsin H