title: Design of a functional hexapeptide antagonist of endothelin.
authors.affiliation: Department of Medicinal Chemistry, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan 48106.
authors.forename: W L
authors.initials: WL
authors.lastname: Cody
authors.forename: A M
authors.initials: AM
authors.lastname: Doherty
authors.forename: J X
authors.initials: JX
authors.lastname: He
authors.forename: P L
authors.initials: PL
authors.lastname: DePue
authors.forename: S T
authors.initials: ST
authors.lastname: Rapundalo
authors.forename: G A
authors.initials: GA
authors.lastname: Hingorani
authors.forename: T C
authors.initials: TC
authors.lastname: Major
authors.forename: R L
authors.initials: RL
authors.lastname: Panek
authors.forename: D T
authors.initials: DT
authors.lastname: Dudley
authors.forename: S J
authors.initials: SJ
authors.lastname: Haleen
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D016232:Endothelins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000494:pharmacology; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D007295:Inositol Phosphates / Q000378:metabolism; D008969:Molecular Sequence Data; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D009842:Oligopeptides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D010446:Peptide Fragments / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism; D017466:Receptors, Endothelin; D013329:Structure-Activity Relationship; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D016232:Endothelins; D007295:Inositol Phosphates; D009842:Oligopeptides; D010446:Peptide Fragments; D011956:Receptors, Cell Surface; D017466:Receptors, Endothelin; C076213:PD 142893; D016718:Arachidonic Acid