Effects of pentoxifylline on equine neutrophil function and flow properties.
Pentoxifylline has been reported to improve peripheral vascular circulation by altering the flow properties of blood. To determine if the hemorrheological effects of pentoxifylline were mediated by alterations in neutrophil function and/or flow properties, we evaluated the drug's effects on equine neutrophils in vitro. Pentoxifylline, at a concentration of 1 x 10(-1) M, but not at concentrations of 1 x 10(-6) M to 1 x 10(-2) M, markedly suppressed neutrophil superoxide production, zymosan phagocytosis and adherence to nylon wool. Pentoxifylline failed to improve neutrophil filterability through 3 mu polycarbonate filters at any concentration tested. We conclude that equine neutrophil function and flow properties are unlikely to be affected by pentoxifylline concentrations achievable in vivo.
Weiss
D J
DJ
Department of Veterinary PathoBiology, University of Minnesota, St. Paul 55108.
Geor
R J
RJ
Burris
S M
SM
Smith
C M
CM
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002478:Cells, Cultured; D005374:Filtration; D006736:Horses / Q000097:blood*; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D010431:Pentoxifylline / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects; D013481:Superoxides / Q000378:metabolism
D013481:Superoxides; D010431:Pentoxifylline