Urethral reconstruction with a new synthetic absorbable device. An experimental study.
Four centimeters of the canine urethra was replaced by a graft consisting of a polyglactin fiber mesh tube, coated with polyhydroxybutyric acid. Microscopic examination 8-12 months later showed almost complete regeneration of the urethral epithelium and the adjacent connective tissue. The neo-urethra was patent and there were no anastomotic strictures, nor was there any inflammatory reaction around the urethra. The validity of this concept in humans remains to be proved.
Olsen
L
L
Department of Pediatric Surgery, University Hospital, Uppsala, Sweden.
Bowald
S
S
Busch
C
C
Carlsten
J
J
Eriksson
I
I
D000818:Animals; D004285:Dogs; D006885:Hydroxybutyrates; D008297:Male; D011100:Polyglycolic Acid; D019736:Prostheses and Implants; D011474:Prosthesis Design; D012038:Regeneration / Q000502:physiology*; D014521:Urethra / Q000473:pathology / Q000601:surgery*; D014945:Wound Healing / Q000502:physiology
D006885:Hydroxybutyrates; D011100:Polyglycolic Acid