title: [Lowering cholesterol with Anticholest--a high fiber guar-apple pectin drink].
abstract: In order to determine the efficacy of Anticholest, an apple-pectin-guar soft-drink in reducing elevated cholesterol (c) levels, 33 participants (aged from 8 to 73 years) were divided into three groups of comparable age, body-mass index, total c, LDL-c, HDL-c, and triglycerides. They received this combined fiber product either (group 1) at dosages of 1 cup (17 g) every second day, or (group 2) of 1 cup a day or (group 3) of 2 cups a day. Anticholest significantly reduced total c, LDL-c and the total c/HDL-c ratio. In group 3 HDL-c was increased significantly (p less than 0.01). The average percentage decrease in total c was 10.0% for group 1, 10.7% for group 2, and 15.7% for group 3. LDL-c was lowered 14.4% in group 1, 13.8% in group 2 and 19.1% in group 3. The highest individual reduction amounted to more than 30% for total-c and LDL-c. A significant decrease was also detected in the triglycerides (tg) in group 3 (p less than 0.05). 7 patients were non-responders. Anticholest appears to be an appropriate treatment for patients at risk of coronary heart disease with insufficient or inadequate response to dietary measures, but where long-term pharmacotherapy is not yet indicated. The lack of side effects and its form of administration as a viscous drink are important determinants for long-term compliance, which is essential in the management of a chronic progressive disease such as atherosclerosis.
authors.affiliation: Wilhelm Auerswald Atheroskleroseforschungsgruppe (ASF)/Kommission für Atheroskleroseforschung, Osterreichischen Akademie der Wissenschaften ATK.
authors.forename: C
authors.initials: C
authors.lastname: Pirich
authors.forename: P
authors.initials: P
authors.lastname: Schmid
authors.forename: J
authors.initials: J
authors.lastname: Pidlich
authors.forename: H
authors.initials: H
authors.lastname: Sinzinger
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004043:Dietary Fiber / Q000008:administration & dosage*; D005260:Female; D005526:Food, Formulated; D005685:Galactans / Q000008:administration & dosage*; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000628:therapy*; D008297:Male; D008351:Mannans / Q000008:administration & dosage*; D008875:Middle Aged; D010368:Pectins / Q000008:administration & dosage*; D053149:Plant Gums; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D004043:Dietary Fiber; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; D014280:Triglycerides; D010368:Pectins; D002784:Cholesterol; C007894:guar gum
vernacular_title: Cholesterinsenkung durch Anticholest--eine ballaststoffrieche Guar-Apfelpektin-Kaltschale.