Intracellular sodium and potassium activities of skeletal muscle fibres of hypothyroid rats.
In soleus muscle fibres of hypothyroid rats, the membrane potential (Vm) and the intracellular K+ activity (aKi) were significantly lower than in control muscles. These results are consistent with the well-documented decrease in the number of Na(+)-K+ pumps which occurs in hypothyroid muscles. aNai was unchanged in the hypothyroid muscles but this may reflect a change in passive Na+ fluxes which has been reported to occur in association with changes in the number of pump units.
MacDermott
M
M
Department of Physiology, Royal College of Surgeons, Dublin, Ireland.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D007037:Hypothyroidism / Q000139:chemically induced / Q000378:metabolism*; D007425:Intracellular Membranes / Q000378:metabolism*; D008297:Male; D009132:Muscles / Q000378:metabolism*; D009206:Myocardium / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D009994:Osmolar Concentration; D010472:Perchlorates / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism*; D017670:Sodium Compounds
D010472:Perchlorates; D017670:Sodium Compounds; C031068:sodium perchlorate; D012964:Sodium; D011188:Potassium