Platelet 3H-imipramine uptake receptor density and serum serotonin levels in patients with fibromyalgia/fibrositis syndrome.
The density of serotonin reuptake receptors on peripheral platelets from 22 patients with primary fibromyalgia syndrome (FS) and the serum serotonin concentrations in 9 patients with FS were compared with those of matched healthy controls. The mean serum serotonin concentration was lower (p = 0.01) in FS than in controls, while the binding of 3H-imipramine was higher (p = 0.035) and normalized with treatment using a combination of ibuprofen and alprazolam. Improvement in selected clinical measures of FS disease activity during treatment correlated with the change in platelet 3H-imipramine binding. These findings support the proposed hypothesis of aberrant pain perception in FS resulting from a deficiency of serotonin.
Russell
I J
IJ
Department of Medicine, University of Texas Health Science Center, San Antonio 78284-7874.
Michalek
J E
JE
Vipraio
G A
GA
Fletcher
E M
EM
Javors
M A
MA
Bowden
C A
CA
D001792:Blood Platelets / Q000378:metabolism*; D002352:Carrier Proteins; D003863:Depression / Q000175:diagnosis / Q000209:etiology; D005356:Fibromyalgia / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D006801:Humans; D007099:Imipramine / Q000378:metabolism; D008995:Monoamine Oxidase / Q000097:blood; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D012016:Reference Values; D012701:Serotonin / Q000097:blood*; D011795:Surveys and Questionnaires; D013577:Syndrome; D014316:Tritium
D002352:Carrier Proteins; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; C027775:imipramine receptor; D014316:Tritium; D012701:Serotonin; D008995:Monoamine Oxidase; D007099:Imipramine