title: Characterization of a kallidin receptor in the eel intestine.
abstract: Edman degradation of an eel bradykinin (BK) -like peptide isolated and detected by gel filtration and HPLC and RIA gave an amino acid sequence of Arg1-Pro-Pro-Gly-X-Ser-Pro-Leu-Arg9. Kallidin but not BK and des-Arg9-BK contracted eel intestine. The contractile effect of kallidin was not decreased by B1 and B2 receptor antagonists (up to 10(-6)M), nor by anticholinergics, antiadrenergics, ganglion blockers and an angiotensin II receptor antagonist but was attenuated by 10(-5)M indomethacin. Kallidin appears to interact with a receptor different from the BK B1 and B2 receptor types and prostaglandins may participate in the response.
authors.affiliation: Department of Animal and Plant Sciences, Sheffield University, UK.
authors.forename: N
authors.initials: N
authors.lastname: Cougnon
authors.forename: C F
authors.initials: CF
authors.lastname: Deacon
authors.forename: K S
authors.initials: KS
authors.lastname: Lilley
authors.forename: I W
authors.initials: IW
authors.lastname: Henderson
mesh_terms: D000595:Amino Acid Sequence; D000811:Anguilla; D000818:Animals; D001920:Bradykinin / Q000031:analogs & derivatives / Q000494:pharmacology*; D066298:In Vitro Techniques; D007422:Intestines / Q000187:drug effects / Q000502:physiology*; D007609:Kallidin / Q000302:isolation & purification / Q000494:pharmacology*; D008969:Molecular Sequence Data; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D018002:Receptors, Bradykinin; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000502:physiology*
chemical_list: D018002:Receptors, Bradykinin; D011956:Receptors, Cell Surface; C078647:kallidin receptor; D007609:Kallidin; D001920:Bradykinin