title: Intermittent jaundice by tumor emboli from intrahepatic cholangiocarcinoma.
abstract: Free-floating tumor debris or mucobilia as a cause of intermittent obstruction has been described infrequently. A patient with intermittent jaundice caused by tumor emboli from an intrahepatic polypoid mucinous cholangiocarcinoma is presented. Symptoms of intermittent jaundice and midepigastric pain persisted over 5 years despite an initial cholecystectomy and common bile duct exploration before definitive diagnosis and treatment of an hepatic trisegmentectomy (segments II, III, and IV). Intraductal mucin was confirmed intraoperatively and pathologically as the cause of the obstructive jaundice. The patient remains asymptomatic and without evidence of disease more than 5 years postoperatively. This report of a predominantly mucin-producing intrahepatic cholangiocarcinoma details a rare protracted clinical course of intermittent biliary obstruction from mucus emboli and highlights the possibility of long-term survival after complete resection.
authors.affiliation: Department of Surgery, Mayo Clinic, Rochester, Minnesota.
authors.forename: P J
authors.initials: PJ
authors.lastname: Capizzi
authors.forename: C B
authors.initials: CB
authors.lastname: Rosen
authors.forename: D M
authors.initials: DM
authors.lastname: Nagorney
mesh_terms: D002759:Adenoma, Bile Duct / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D000368:Aged; D001650:Bile Duct Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D001663:Bilirubin / Q000097:blood; D002763:Cholecystectomy; D002780:Cholestasis, Intrahepatic / Q000209:etiology* / Q000601:surgery; D006801:Humans; D008297:Male; D009360:Neoplastic Cells, Circulating; D014057:Tomography, X-Ray Computed
chemical_list: D001663:Bilirubin