Modulation of Ca2+ release and Na+ channel function in skeletal muscle by fatty acids.
Ca(2+)- and halothane-induced Ca(2+) release and Na+ currents are modulated by free fatty acids (FAs). FA modulation of ion currents may have important implications for general muscle physiology and skeletal muscle disorders, including malignant hyperthermia (MH).
Fletcher
J E
JE
Hahnemann University, Philadelphia, PA.
Wieland
S J
SJ
Beech
J
J
Heiman-Patterson
T D
TD
Rosenberg
H
H
D002118:Calcium / Q000378:metabolism* / Q000494:pharmacology; D002478:Cells, Cultured; D006221:Halothane / Q000494:pharmacology*; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D008042:Linolenic Acids / Q000378:metabolism*; D008305:Malignant Hyperthermia / Q000378:metabolism*; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D019301:Oleic Acid; D009829:Oleic Acids / Q000494:pharmacology*; D015222:Sodium Channels / Q000187:drug effects / Q000502:physiology*
D008042:Linolenic Acids; D009829:Oleic Acids; D015222:Sodium Channels; D019301:Oleic Acid; D007545:Isoproterenol; D002118:Calcium; D006221:Halothane