Adjuvant chemotherapy for colorectal hepatic metastases: role of route of administration and timing.
Improved results in the adjuvant and therapeutic treatment of colon cancer has led to renewed interest in the role of adjuvant chemotherapy following liver resection for colorectal hepatic metastases. However, little is known about the most effective method or timing of delivery of adjuvant chemotherapy. Sixty-nine BD-IX rats underwent a right hepatic lobectomy following tumour inoculation via a splenic injection of 10(7) K12/TRb colon cancer cells. The rats were then randomized to receive systemic FUdR (1 mg kg-1 d-1 for 7 d) or regional (hepatic artery or portal vein) FUdR (2 mg kg-1 d-1 for 7 d) immediately or 72 h following tumour injection. On Day 28, a laprotomy was performed, and tumour nodules in the liver were counted. The animals were followed to death, and at autopsy the cause of death from hepatic or extrahepatic metastases was determined. All methods of FUdR infusion were superior to no treatment. Immediate portal vein (PV) FUdR infusion delayed the appearance of hepatic tumour (P = 0.003), changed the cause of death from hepatic to extrahepatic disease (P = 0.019), and prolonged survival (P < 0.05). Infusion of FUdR via the PV 72 h later did not delay the appearance of hepatic tumours nor prolong survival. In contrast, delayed HA FUdR infusion controlled hepatic metastases (P = 0.04) and improved survival (P < 0.05).
Sutanto-Ward
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Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
Sigurdson
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ER
Tremiterra
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S
Lincer
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Chapman
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Niedzwiecki
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D
D000818:Animals; D017024:Chemotherapy, Adjuvant / Q000379:methods; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D004354:Drug Screening Assays, Antitumor; D005467:Floxuridine / Q000008:administration & dosage*; D006498:Hepatectomy; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D009368:Neoplasm Transplantation; D011182:Postoperative Care / Q000379:methods; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D005467:Floxuridine