title: Treatment of human cutaneous sporotrichosis with itraconazole.
abstract: Eighteen adult white male patients with cutaneous sporotrichosis were treated with itraconazole following different daily dose schemes. Cure was obtained in all cases after periods of 15-75 days (median 44 days) with total doses between 3.1 and 14.8 g (median 8.4 g). No serious side effects were observed and no relapses occurred in the follow-up period of between 1 and 26 months (median 14.7). These results show that itraconazole represents a safe and effective drug for the treatment of sporotrichosis. Comparison with other studies leads us to consider a daily dose of 200 mg as the most appropriate. A concomitant warming of the affected limbs should be recommended.
authors.affiliation: Department of Parasitology, School of Medicine, University of the Republic, Montevideo, Uruguay.
authors.forename: I A
authors.initials: IA
authors.lastname: Conti Díaz
authors.forename: E
authors.initials: E
authors.lastname: Civila
authors.forename: E
authors.initials: E
authors.lastname: Gezuele
authors.forename: M
authors.initials: M
authors.lastname: Lowinger
authors.forename: L
authors.initials: L
authors.lastname: Calegari
authors.forename: D
authors.initials: D
authors.lastname: Sanabria
authors.forename: L
authors.initials: L
authors.lastname: Fuentes
authors.forename: D
authors.initials: D
authors.lastname: Da Rosa
authors.forename: G
authors.initials: G
authors.lastname: Alzueta
mesh_terms: D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D006801:Humans; D017964:Itraconazole; D007654:Ketoconazole / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D013174:Sporotrichosis / Q000188:drug therapy*
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D007654:Ketoconazole