title: Atypical herpes simplex encephalitis: clinical, virologic, and neuropathologic evaluation.
abstract: An atypical form of herpes simplex encephalitis produced by HSV-1 documented in the present article demonstrates that (1) prominent EEG abnormality may correlate with subtle increase in signal intensity on MRI; (2) the disease may start with prominent involvement of the cingulate gyri; and (3) viral infection of the brainstem may cause early onset of severe neurologic dysfunction and coma.
authors.affiliation: Neurovirology Research Laboratory, Veterans Affairs Medical Center, Salt Lake City, UT 84148.
authors.forename: J W
authors.initials: JW
authors.lastname: Rose
authors.forename: W G
authors.initials: WG
authors.lastname: Stroop
authors.forename: F
authors.initials: F
authors.lastname: Matsuo
authors.forename: J
authors.initials: J
authors.lastname: Henkel
mesh_terms: D001933:Brain Stem / Q000382:microbiology / Q000473:pathology; D004569:Electroencephalography; D004660:Encephalitis / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology; D005260:Female; D006179:Gyrus Cinguli / Q000382:microbiology / Q000473:pathology; D006561:Herpes Simplex / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D018139:Simplexvirus / Q000235:genetics / Q000302:isolation & purification