[Probable compact structure of a cis-active translation element in the 5'-untranslated region of the enterovirus and rhinovirus genome].
A previously proposed consensus secondary structure model of the internal portion of the 5'-untranslated region of the enterovirus and rhinovirus genomes encompassing the cis-acting translational control element was extended and detailed on the basis of comparative sequence data and biochemical analysis. Using this model as a reference, numerous pairs of apparently single-stranded noncontiguous nucleotide stretches with a potential to form inter-domain tertiary bonds were shown to be conserved among the respective segments of all the known enterovirus and rhinovirus RNAs. It is suggested that at least some of these inter-domain bonds may actually exist, resulting in a compact, quasi-globular, perhaps "two-lobe" folding of the translational control element. Such an organization should have important functional implications.
Pilipenko
E V
EV
Maslova
S V
SV
Agol
V I
VI
D001483:Base Sequence; D004247:DNA; D004770:Enterovirus / Q000235:genetics*; D016679:Genome, Viral; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D014176:Protein Biosynthesis; D012367:RNA, Viral / Q000737:chemistry; D012229:Rhinovirus / Q000235:genetics*
D012367:RNA, Viral; D004247:DNA
Veroiatnaia kompaktnaia struktura tsis-aktivnogo transliatsionnogo élementa v 5'-netransliruemoĭ zone genoma énterovirusov i rinovirusaov.