The angiotensin AT2 receptor modulates T-type calcium current in non-differentiated NG108-15 cells.
We report here that angiotensin II (AII) and the AT2 receptor-selective ligand, CGP 42112, modulate the T-type calcium current in non-differentiated NG108-15 cells, which express only AT2 receptors. Both peptides decrease the T-type calcium current at membrane potentials above -40 mV and shift the current-voltage curve at lower potentials with maximal effect between 5 and 10 min after application. These data describe a new cellular response to AII and suggest that the AT2 receptor mediates certain neurophysiological actions of this hormone.
Buisson
B
B
Service of Endocrinology, Faculty of Medicine, University of Sherbrooke, Qué., Canada.
Bottari
S P
SP
de Gasparo
M
M
Gallo-Payet
N
N
Payet
M D
MD
D000200:Action Potentials; D000804:Angiotensin II / Q000037:antagonists & inhibitors / Q000502:physiology*; D057911:Angiotensin Receptor Antagonists; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D002460:Cell Line; D009474:Neurons / Q000502:physiology*; D011945:Receptors, Angiotensin / Q000502:physiology*
D057911:Angiotensin Receptor Antagonists; D015220:Calcium Channels; D011945:Receptors, Angiotensin; D000804:Angiotensin II; D002118:Calcium