Interferon pretreatment regulates interferon and interleukin-6 production in L929 cells in a coordinated manner.
Two sublines of L929 cells with different interferon (IFN)-producing capacities synthesized IFN and interleukin-6 (IL-6) simultaneously in response to Sendai virus infection. IFN pretreatment primed the production of both cytokines. However, the difference in IL-6 production between the "high and low producer" L-cell sublines was about one magnitude of order larger than in the case of their IFN production. The determination of the corresponding mRNA levels also reflected this difference.
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Institute of Microbiology, Albert Szent-Gyorgyi Medical University, Szeged, Hungary.
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Megyeri
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D000818:Animals; D002460:Cell Line; D016899:Interferon-beta / Q000096:biosynthesis / Q000235:genetics / Q000494:pharmacology*; D015850:Interleukin-6 / Q000096:biosynthesis* / Q000235:genetics; D010222:Parainfluenza Virus 1, Human; D018184:Paramyxoviridae Infections / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis
D015850:Interleukin-6; D012333:RNA, Messenger; D016899:Interferon-beta