[The effect of stress on the enzyme systems of the enterocyte microvilli in rat pups and the possible mechanism of the transmission of stress effects from dam to progeny].
In suckling rats whose mothers had had an immobilisation stress or been injected HC and T4 at the last day of their pregnancy, the sucrase induction decreased in the small intestine, if the HC was injected on the 10th day of life. The hormone injection to 1-day suckling rats did not affect the induction. These effects seem to be exerted not by the direct permeation of hormone from mother to litter but to be mediated rather by a special factor "stressin". The latter is transferred from mother to litter and decreases the sensitivity of intestinal enzymes to exogenous HC, thus exerting an antistressor effect.
Egorova
V V
VV
Shinder
D A
DA
Rakhimov
K R
KR
Ugolev
A M
AM
D000818:Animals; D000831:Animals, Newborn; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology; D007421:Intestine, Small / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology* / Q000648:ultrastructure; D043322:Lactase; D008871:Microvilli / Q000187:drug effects / Q000201:enzymology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000201:enzymology* / Q000209:etiology; D013393:Sucrase / Q000032:analysis / Q000187:drug effects / Q000378:metabolism; D013974:Thyroxine / Q000494:pharmacology; D001616:beta-Galactosidase / Q000032:analysis / Q000187:drug effects / Q000378:metabolism
D043322:Lactase; D001616:beta-Galactosidase; D013393:Sucrase; D013974:Thyroxine; D006854:Hydrocortisone
Vliianie stressa na fermentnye sistemy mikrovorsinok énterotsitov u krysiat i vozmozhnyĭ mekhanizm peredachi stressornykh éffektov ot materi k potomstvu.