[The effect of the deprivation of the paradoxical sleep stage on the temporal dynamics of swimming in rats with antidepressive and depressant exposures].
After REM sleep deprivation the time-course of the forced swimming was reorganized. As shown, reduction of rhythmical index of depression, such effect has an antidepressive nature. In this model potentiation of specific activity of antidepressant imipramine and attenuation of depressive properties of clonidine were observed. These results suggest that shifts in sleep phase structure may be a source of restriction of circadian desynchronosis, upon which depression is based.
Baturin
V A
VA
Arushanian
A E
AE
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D003000:Clonidine / Q000494:pharmacology; D003863:Depression / Q000139:chemically induced / Q000503:physiopathology*; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D005082:Physical Exertion / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D012149:Restraint, Physical; D012892:Sleep Deprivation / Q000502:physiology*; D012895:Sleep, REM / Q000187:drug effects / Q000502:physiology*; D013550:Swimming; D013997:Time Factors
D000928:Antidepressive Agents; D003000:Clonidine; D007099:Imipramine
Vliianie deprivatsii paradoksal'noĭ fazy sna na vremennúiu dinamiku plavaniia u krys pri antidepressivnom i depressogennom vozdeĭstvii.