[Characteristics of the dynamics of rapid changes in blood phosphoinositides in patients with alcoholic heart diseases].
A total of 42 patients who had been abusing alcoholic beverages during different periods and 12 healthy individuals were examined. Their intracardiac hemodynamic parameters were evaluated by echocardiography and rapid changes in inositol-containing blood lipids were determined by thin-layer flow chromatography. The patients showed significantly reduced contractility of the left ventricle, its wall hypertrophy and greater cavity dimensions. These abnormalities were more pronounced in patients with an over 10-year history. Biochemical studies revealed a time course of rapid changes in inositol-containing lipids in patients, which showed more fluctuations in the content of phosphoinositides and their lower baseline and final levels and differed from that in healthy persons. It was stressed that the changes in inositol-containing lipids were also related to the duration of alcohol abuse and they reflected the mechanisms of the toxic action of ethanol on the myocardium, which might be useful in the assessment of the severity of cardiovascular events in alcoholism.
Anikin
V V
VV
Kornysheva
E A
EA
Kargapolov
A V
AV
D000328:Adult; D002310:Cardiomyopathy, Alcoholic / Q000097:blood* / Q000503:physiopathology; D002855:Chromatography, Thin Layer; D004452:Echocardiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D010716:Phosphatidylinositols / Q000097:blood*; D013997:Time Factors
D010716:Phosphatidylinositols
Ossobennosti dinamiki bystrykh izmeneniĭ fosfoinozitidov v krovi bol'nykh s alkogol'nym porazheniem serdtsa.