title: Mineralocorticoid hormone action in plant cells.
abstract: The multiplication of Chlamydomonas reinhardtii wild type cells can be arrested by the spirolactone RU 26752 and this is fully reversible by the natural mineralocorticoid aldosterone. Evidence is presented for a 52 kDa protein that possesses functional DNA and ligand binding domains and tests positive for mineralocorticoid receptor-like activity by immuneprecipitation, macroaggregation, and photoaffinity. The regulation of trans-activation by steroid hormones in the animal world would therefore appear to be just as valid for the plant kingdom, thereby providing a new model for genetic analysis.
authors.affiliation: INSERM U-86, Centre Universitaire des Cordeliers, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Mirshahi
authors.forename: A
authors.initials: A
authors.lastname: Mirshahi
authors.forename: A
authors.initials: A
authors.lastname: Nato
authors.forename: M K
authors.initials: MK
authors.lastname: Agarwal
mesh_terms: D000450:Aldosterone / Q000494:pharmacology*; D000818:Animals; D016825:Chlamydomonas reinhardtii / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D002852:Chromatography, Ion Exchange; D003600:Cytosol / Q000187:drug effects / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000302:isolation & purification / Q000378:metabolism*; D007074:Immunoglobulin G / Q000302:isolation & purification; D008970:Molecular Weight; D018161:Receptors, Mineralocorticoid; D011987:Receptors, Steroid / Q000187:drug effects / Q000302:isolation & purification / Q000378:metabolism*; D013148:Spironolactone / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology
chemical_list: D004268:DNA-Binding Proteins; D007074:Immunoglobulin G; D018161:Receptors, Mineralocorticoid; D011987:Receptors, Steroid; D013148:Spironolactone; D000450:Aldosterone; C047175:7-propyl spirolactone