A novel neuroendocrine gene product: selective VGF8a gene expression and immuno-localisation of the VGF protein in endocrine and neuronal populations.
The VGF8a gene was recognised on the basis of its inducibility by NGF in rat pheochromocytoma (PC12) cells. Using immunocytochemistry, we have localised the corresponding VGF protein product in various neuronal groups, including primary sensory and enteric neurons, and in endocrine cells of the adrenal medulla, adenohypophysis and gut. VGF8a gene expression, as detected by RNAse protection analysis, largely correlated with such distribution.
Ferri
G L
GL
Department of Cytomorphology, University of Cagliari, Italy.
Levi
A
A
Possenti
R
R
D000313:Adrenal Medulla / Q000166:cytology / Q000502:physiology*; D000818:Animals; D003106:Colon / Q000294:innervation*; D005455:Fluorescent Antibody Technique; D005727:Ganglia, Spinal / Q000166:cytology / Q000502:physiology; D015870:Gene Expression / Q000187:drug effects; D007106:Immune Sera; D007124:Immunoenzyme Techniques; D007413:Intestinal Mucosa / Q000294:innervation; D009412:Nerve Fibers / Q000502:physiology; D009414:Nerve Growth Factors / Q000494:pharmacology; D009474:Neurons / Q000502:physiology*; D009475:Neurons, Afferent / Q000502:physiology; D016716:PC12 Cells; D010903:Pituitary Gland, Anterior / Q000166:cytology / Q000502:physiology*; D011506:Proteins / Q000032:analysis* / Q000235:genetics*; D013116:Spinal Cord / Q000166:cytology / Q000502:physiology*
D007106:Immune Sera; D009414:Nerve Growth Factors; D011506:Proteins