title: [Treatment of exterior extension of choroid melanomas by accelerated proton beams].
abstract: Among the 934 patients with a choroidal melanoma treated in first intention with an accelerated proton beam since 1984, 41 (4.4%) presented an extrascleral extension, of which 11 were located anteriorly and 30 posteriorly. For these 30 cases, the diagnosis was made by B ultrasonography only when the volume of the extension was important, between 20 and 2280 mm3. The Cox model multi-variant analysis was used to study the statistically significant parameters in the development of an extrascleral extension. It appears that the maximal diameter of the intraocular tumor (p = 0.0012), the localisation of the anterior margin (p = 0.0304) and the age of the patients (p = 0.0097) are statistically meaningful. The 4 years' survival, studied with the Kaplan-Meier curves, is estimated at 60% for the patients with extrascleral extension and at 85% for the patients without. These results are similar to those of literature, whatever treatment is chosen (enucleation and radiotherapy, exenteration).
authors.affiliation: Clinique ophtalmologique universitaire de Lausanne, Hôpital Jules Gonin.
authors.forename: L
authors.initials: L
authors.lastname: Bercher
authors.forename: L
authors.initials: L
authors.lastname: Zografos
authors.forename: E
authors.initials: E
authors.lastname: Egger
authors.forename: L
authors.initials: L
authors.lastname: Chamot
authors.forename: S
authors.initials: S
authors.lastname: Uffer
authors.forename: C
authors.initials: C
authors.lastname: Gailloud
authors.forename: N
authors.initials: N
authors.lastname: Ducrey
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002830:Choroid Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000532:radiotherapy*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000532:radiotherapy; D009367:Neoplasm Staging; D011522:Protons; D011879:Radiotherapy Dosage
chemical_list: D011522:Protons
vernacular_title: Le traitement des mélanomes exteriorisés de la choroide par faisceau de protons accelerés.