title: The influence of normobaric hyperoxia on lung surfactant phospholipids in rats.
abstract: The influence of 12-, 24- and 48-h normobaric hyperoxia on phospholipid composition of lung surfactant in rats was investigated. Both in surfactant isolated from bronchoalveolar lavage and in surfactant isolated from lung tissue after 12 h breathing of pure oxygen, a decrease in both phosphatidylcholine (particularly in disaturated ones) and phosphatidylglycerol content was observed. This decrease was compensated with concomitant increase in lysophosphoglyceride content. A drop in total phospholipid level in surfactant of oxygen-exposed rats was observed. These data suggest that normobaric hyperoxia causes a substantial changes in lung surfactant composition and type II pneumocyte metabolism.
authors.affiliation: Department of Pathophysiology, Veterinary Medicine Faculty, Agricultural University, Lublin, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Ledwozyw
authors.forename: B
authors.initials: B
authors.lastname: Borowicz
mesh_terms: D000818:Animals; D001992:Bronchoalveolar Lavage Fluid; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010100:Oxygen / Q000494:pharmacology*; D010713:Phosphatidylcholines / Q000378:metabolism; D010715:Phosphatidylglycerols / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D011663:Pulmonary Surfactants / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D010713:Phosphatidylcholines; D010715:Phosphatidylglycerols; D010743:Phospholipids; D011663:Pulmonary Surfactants; D010100:Oxygen