title: Arterial blood gases during cardiac arrest: markers of blood flow in a canine model.
abstract: Measures of CO2 have been shown to correlate with coronary perfusion pressure and cardiac output during cardiac arrest. We evaluated arterial pH (pHa) relative to blood flow during cardiac arrest in a canine electromechanical dissociation (EMD) model of cardiac arrest using different resuscitation techniques. Following 15 min of cardiac arrest, 24 mongrel dogs received epinephrine with continued CPR or closed-chest cardiopulmonary bypass. Central arterial blood gases, end-tidal carbon dioxide (PetCO2), coronary perfusion pressure and cardiac output were measured. During CPR, prior to epinephrine or bypass, there was no correlation of pHa, PACO2 and PetCO2, with cardiac output or coronary perfusion pressure. Immediately after instituting the resuscitation techniques, both pHa and PaCO2 showed a significant correlation with cardiac output (pHa; R = -0.78, P less than 0.001 and PaCO2; R = 0.87, P less than 0.001) and with coronary perfusion pressure (pHa; R = -0.75, P less than 0.001 and PaCO2; R = 0.75, P less than 0.001). Eventual survivors (n = 15) had an early significant decrease in pHa, base excess and a significant increase in PaCO2 which was not present in non-survivors (n = 9). Neither pHa nor PaCO2 correlate with blood flow under low flow conditions of CPR. However, with effective circulatory assistance, pHa and PaCO2 reflect systemic blood flow and reperfusion washout.
authors.affiliation: Wright State University School of Medicine, Department of Emergency Medicine, Dayton, OH 45401-0927.
authors.forename: M G
authors.initials: MG
authors.lastname: Angelos
authors.forename: D J
authors.initials: DJ
authors.lastname: DeBehnke
authors.forename: J E
authors.initials: JE
authors.lastname: Leasure
mesh_terms: D000818:Animals; D001158:Arteries; D015415:Biomarkers; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood*; D002302:Cardiac Output; D003326:Coronary Circulation; D004285:Dogs; D004837:Epinephrine / Q000627:therapeutic use; D006323:Heart Arrest / Q000097:blood* / Q000503:physiopathology / Q000628:therapy; D012151:Resuscitation
chemical_list: D015415:Biomarkers; D002245:Carbon Dioxide; D004837:Epinephrine