[Effect of cadmium and lead compounds on behavior of some enzymes in peripheral blood of rats with experimental diabetes].
The aim of these tests was to show whether in an experimental diabetes toxic compounds of the cadmium and lead would intensify changes in the enzymes activity caused by a diabetes itself. The test was carried out on the Wistar breed of rats. After inducing the experimental diabetes animals were given cadmium and lead compounds by searchers directly into their stomachs. The following enzymes the AspAT and the AlAT and the alkaline phosphatase (AP) were indicated among all tested animals. The statistic significant increase of the AspAT and the AlAT and the decrease of the alkaline phosphatase in a blood were documented in the experimental diabetes as well as among animals subjected to the cadmium and lead in comparison with the results secured from the checking group of animals. In comparison to animals with a diabetes itself, in the experimental diabetes the toxic compounds of the cadmium and lead explicitly increased the activity changes of the AlAT and the alkaline phosphatase. On the grounds of the above results it can be assumed that in the diabetic diseases the toxic metals may intensify pathological changes.
Słodowska-Hajduk
Z
Z
Miedzywydziałowej Katedry Patofizjologii, Akademii Medycznej im. M. Kopernika, Krakowie.
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002104:Cadmium / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D007854:Lead / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D002104:Cadmium; D007854:Lead; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase
Wpływ zwiazków kadmu i ołowiu na zachowanie sie niektórych enzymów we krwi obwodowej u szczurów w cukrzycy doświadczalnej.