In vitro activity of CP-74667 compared with four other fluoroquinolones.
CP-74667 is a new, novel C-7 diazabicyclo-fluoroquinolone. Its spectrum of activity includes the Enterobacteriaceae, most nonenteric Gram-negative bacilli, and Gram-positive cocci. Particularly high activity was demonstrated against Xanthomonas maltophilia (MIC50, 1 microgram/ml), Staphylococcus spp. (MIC50s, 0.06-0.12 micrograms/ml) and enterococci (MIC50s, 0.5-4 micrograms/ml). Several staphylococci resistant to ciprofloxacin had potentially susceptible range MICs for CP-74667, for example, less than or equal to 2 micrograms/ml. Fluoroquinolones with this C-7 modification appear promising and worthy of continued pharmaceutical investigation.
Jones
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RN
Department of Pathology, University of Iowa College of Medicine, Iowa City 52242.
Erwin
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ME
D000890:Anti-Infective Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D015365:Enoxacin / Q000494:pharmacology; D004755:Enterobacteriaceae / Q000187:drug effects; D024841:Fluoroquinolones; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006095:Gram-Positive Cocci / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009643:Norfloxacin / Q000494:pharmacology; D015242:Ofloxacin / Q000494:pharmacology; D015363:Quinolones / Q000494:pharmacology*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D015365:Enoxacin; D002939:Ciprofloxacin; D015242:Ofloxacin; C077152:7-(8'-methyl-3',8'-diazabicyclo(3.2.1)oct-3'-yl)-1-cyclopropyl-6- fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; D009643:Norfloxacin