title: WF11605, an antagonist of leukotriene B4 produced by a fungus. II. Structure determination.
abstract: The structure of WF11605, a novel tetracyclic triterpene glucoside, was determined to be 1. The plane structure of deacetyl-WF11605 aglycone was elucidated as 2 through the concerted application of a series of 2D NMR techniques. The relative configurations were established by X-ray crystallographic analysis of bis(p-bromobenzoyl) derivative 3 and absolute stereochemistry by CD exciton chirality method.
authors.affiliation: Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Shigematsu
authors.forename: E
authors.initials: E
authors.lastname: Tsujii
authors.forename: N
authors.initials: N
authors.lastname: Kayakiri
authors.forename: S
authors.initials: S
authors.lastname: Takase
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Tada
mesh_terms: D002911:Chrysenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005658:Fungi / Q000737:chemistry; D007975:Leukotriene B4 / Q000037:antagonists & inhibitors*; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D002911:Chrysenes; D014315:Triterpenes; C075545:WF 11605; D007975:Leukotriene B4