title: Long-term use of gamma-linolenic acid-enriched fat emulsion (PFE 4501): case report.
abstract: A new gamma-linolenic acid-enriched fat emulsion (PFE 4501) was given for 13 mo as part of a home parenteral nutrition regimen to a 28-yr-old patient with cystic fibrosis. Blood biochemistry, hematological data, and fatty acid profile were followed. No side effects were reported, and pulmonary function tests remained stable. gamma-Linolenic acid appears to be safe for clinical use and may benefit patients with derangements in essential fatty acid metabolism. The potential role of a gamma-linolenic acid-enriched intravenous fat emulsion is discussed.
authors.affiliation: Department of Anesthesiology, Montefiore Medical Center, Bronx, New York 10467.
authors.forename: E
authors.initials: E
authors.lastname: Söreide
authors.forename: B
authors.initials: B
authors.lastname: Skeie
authors.forename: D P
authors.initials: DP
authors.lastname: Katz
authors.forename: T
authors.initials: T
authors.lastname: Manner
authors.forename: J
authors.initials: J
authors.lastname: Askanazi
mesh_terms: D000328:Adult; D003550:Cystic Fibrosis / Q000628:therapy*; D004338:Drug Combinations; D005217:Fat Emulsions, Intravenous; D005260:Female; D005990:Glycerol / Q000627:therapeutic use*; D006801:Humans; D008042:Linolenic Acids / Q000008:administration & dosage* / Q000627:therapeutic use*; D010288:Parenteral Nutrition; D016331:Parenteral Nutrition, Home; D010743:Phospholipids / Q000627:therapeutic use*; D013024:Soybean Oil / Q000627:therapeutic use*; D017965:gamma-Linolenic Acid
chemical_list: D004338:Drug Combinations; D005217:Fat Emulsions, Intravenous; D008042:Linolenic Acids; D010743:Phospholipids; C076797:pediatric fat emulsion 4501; D017965:gamma-Linolenic Acid; D013024:Soybean Oil; D005990:Glycerol