[Effect of blockade of opiate receptors by naloxone on lutropin (LH), follitropin (FSH) and testosterone secretion in patients after kidney transplantation].
The influence of opioid receptors blockade by naloxone on lutropin (LH), follitropin (FSH) and testosterone secretion induced by LH-RH was assessed in 12 male kidney transplant patients with stable graft function (KTP) treated by cyclosporine A and prednisone and in 15 healthy subjects. In KTP normal plasma levels of LH in spite of significantly reduced testosteronemia and a reduced response of LH to LH-RH was observed. After blockade of opioid receptors by naloxone normalization of the response of LH secretion to LH-RH was found and a higher increase of the plasma testosterone level was observed in KTP than in healthy subjects. Results obtained in this study suggest abnormal functioning of the hypothalamic-pituitary--gonadal axis in KTP and participation of opioid receptors in its pathogenesis.
Grzeszczak
W
W
Katedry i Kliniki Nefrologii Slaskiej Akademii Medycznej, Katowicach.
Zukowska-Szczechowska
E
E
Kokot
F
F
D000328:Adult; D016572:Cyclosporine / Q000008:administration & dosage; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D016030:Kidney Transplantation / Q000502:physiology*; D007986:Luteinizing Hormone / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology*; D011182:Postoperative Care; D011241:Prednisone / Q000008:administration & dosage; D011957:Receptors, Opioid / Q000187:drug effects* / Q000502:physiology; D013268:Stimulation, Chemical; D013739:Testosterone / Q000378:metabolism*
D011957:Receptors, Opioid; D007987:Gonadotropin-Releasing Hormone; D009270:Naloxone; D013739:Testosterone; D016572:Cyclosporine; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D011241:Prednisone
Wpływ blokady receptorów opioidowych naloksonem na sekrecje lutropiny (LH), folitropiny (FSH) i testosteronu u chorych z przeszczepiona nerka.