The gene for the alpha 1 subunit of the skeletal muscle dihydropyridine-sensitive calcium channel (Cchl1a3) maps to mouse chromosome 1.
Cchl1a3 encodes the dihydropyridine-sensitive calcium channel alpha 1 subunit isoform predominantly expressed in skeletal muscle. mdg (muscular dysgenesis) has previously been implicated as a mutant allele of this gene. Hybridization of a rat brain cDNA probe for Cchl1a3 to Southern blots of DNAs from a panel of Chinese hamster x mouse somatic cell hybrids suggested that this gene maps to mouse Chromosome 1. Analysis of the progeny of an inbred strain cross-positioned Cchl1a3 1.3 cM proximal to the Pep-3 locus on Chr 1.
Chin
H
H
Laboratory of Molecular Biology, NINDS, National Institutes of Health, Bethesda, Maryland 20892.
Krall
M
M
Kim
H L
HL
Kozak
C A
CA
Mock
B
B
D000818:Animals; D015139:Blotting, Southern; D015220:Calcium Channels / Q000187:drug effects / Q000235:genetics*; D002874:Chromosome Mapping; D006224:Cricetinae; D004247:DNA; D015342:DNA Probes; D004095:Dihydropyridines / Q000494:pharmacology*; D005260:Female; D006239:Haplotypes; D006822:Hybrid Cells; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D009132:Muscles / Q000737:chemistry*
D015220:Calcium Channels; D015342:DNA Probes; D004095:Dihydropyridines; C038806:1,4-dihydropyridine; D004247:DNA