title: Case report 714. Postirradiation osteosarcoma after radiation of metastatic skeletal lesion.
abstract: Two cases of postirradiation osteosarcoma are presented--one in a 76-year-old woman with breast carcinoma and subsequent osteosarcoma after radiation therapy for a metastatic lesion in the right tibia, and the other in a 16-year-old girl with hepatocellular carcinoma metastatic to the left tibia and osteosarcoma after radiation therapy to that bone. Microscopically, both cases were high-grade spindle cell lesions with osteoid production. Both patients fared poorly. This is a rare complication of radiation therapy.
authors.affiliation: Section of Surgical Pathology, Mayo Clinic, Rochester, Minnesota 55905.
authors.forename: B C
authors.initials: BC
authors.lastname: Toorkey
authors.forename: K K
authors.initials: KK
authors.lastname: Unni
authors.forename: D C
authors.initials: DC
authors.lastname: Dahlin
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy / Q000556:secondary; D000293:Adolescent; D000368:Aged; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology / Q000532:radiotherapy; D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000556:secondary; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology; D009381:Neoplasms, Radiation-Induced / Q000000981:diagnostic imaging* / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000000981:diagnostic imaging / Q000473:pathology; D012516:Osteosarcoma / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D011859:Radiography; D011878:Radiotherapy / Q000009:adverse effects; D013977:Tibia / Q000000981:diagnostic imaging