title: High levels of circulating soluble receptors for tumor necrosis factor in hairy cell leukemia and type B chronic lymphocytic leukemia.
abstract: The presence of soluble tumor necrosis factor (TNF) binding proteins (BP) was investigated in the sera of healthy volunteer blood donors and cancer patients. Two distinct types of TNFBP, types A and B, which are immunologically related to the cellular 75-kD TNF receptor (TNFR) and the cellular 55-kD TNFR, respectively, were assessed by immunoassays using nonblocking anti-receptor antibodies and 125I-recombinant human TNF alpha. As compared to the titers observed in 25 healthy controls, TNFBP types A and B titers were found to be elevated in almost all sera obtained from patients with underlying malignant disease. The highest amounts of TNFBP were seen in the sera of patients with B cell malignancies including hairy cell leukemia (HCL) and type B chronic lymphocytic leukemia. Treatment of HCL patients with recombinant human interferon-alpha was associated with decrease of circulating TNFBP.
authors.affiliation: Department of Internal Medicine III, University of Ulm, Federal Republic of Germany.
authors.forename: W
authors.initials: W
authors.lastname: Digel
authors.forename: F
authors.initials: F
authors.lastname: Porzsolt
authors.forename: M
authors.initials: M
authors.lastname: Schmid
authors.forename: F
authors.initials: F
authors.lastname: Herrmann
authors.forename: W
authors.initials: W
authors.lastname: Lesslauer
authors.forename: M
authors.initials: M
authors.lastname: Brockhaus
mesh_terms: D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use; D007943:Leukemia, Hairy Cell / Q000097:blood* / Q000628:therapy; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood* / Q000628:therapy; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism*; D018124:Receptors, Tumor Necrosis Factor; D011994:Recombinant Proteins; D012995:Solubility
chemical_list: D007370:Interferon Type I; D011956:Receptors, Cell Surface; D018124:Receptors, Tumor Necrosis Factor; D011994:Recombinant Proteins