Effect of manidipine on cardiac hypertrophy and coronary circulation in DOCA/salt hypertensive rats.
The effect of manidipine on cardiac hypertrophy, coronary circulation, left ventricular weight and maximal coronary flow in hypertension was measured in DOCA/salt treated systolic hypertensive rats with and without manidipine treatment. Normotensive rats were used as controls. After feeding with 0.05% manidipine-containing food, blood pressure was reduced only in DOCA/salt hypertensive rats, but not in control rats. After 3 weeks of treatment, sodium excretion was significantly increased in DOCA/salt-treated rats with or without manidipine treatment. Hearts were removed and perfused with modified Krebs-Henseleit solution with adenosine (5 x 10(-5) M) in a Langendorff apparatus. Maximal coronary flow (MCF) was significantly decreased only in DOCA/salt hypertensive rats without treatment, while manidipine treatment restored MCF. Left ventricular weight/body weight was also markedly greater in DOCA/salt-treated rats not given manidipine. Left ventricular weight in DOCA/salt-treated rats given manidipine was significantly reduced compared with DOCA/salt hypertensive rats without treatment, although it was heavier than in the control animals. Morphological examination showed that the increased wall/lumen ratio in DOCA/salt hypertensive rats was reduced by manidipine treatment. These findings suggest that treatment with manidipine in DOCA/salt hypertensive rats lowered high blood pressure and improved impaired coronary circulation with a reduction in left ventricular and vascular hypertrophy.
Takeda
K
K
Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Nakata
T
T
Kuwabara
T
T
Itoh
H
H
Yamahara
Y
Y
Takesako
T
T
Tanabe
S
S
Sasaki
S
S
Asayama
J
J
Nakagawa
M
M
D000450:Aldosterone / Q000097:blood; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D006332:Cardiomegaly / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology*; D003326:Coronary Circulation / Q000187:drug effects*; D003331:Coronary Vessels / Q000187:drug effects; D003900:Desoxycorticosterone; D004095:Dihydropyridines / Q000494:pharmacology*; D004573:Electrolytes / Q000097:blood; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000139:chemically induced / Q000150:complications* / Q000188:drug therapy; D008297:Male; D009578:Nitrobenzenes; D010879:Piperazines; D051381:Rats; D017208:Rats, Wistar; D012083:Renin / Q000097:blood; D012965:Sodium Chloride
D000959:Antihypertensive Agents; D004095:Dihydropyridines; D004573:Electrolytes; D009578:Nitrobenzenes; D010879:Piperazines; D003900:Desoxycorticosterone; D012965:Sodium Chloride; D000450:Aldosterone; C054218:manidipine; D012083:Renin