T cell recognition of Mls-like superantigens: analysis of TCR requirements, superantigenic ligands, and signal transduction.
Mls-like endogenous superantigens have been reported to be unique, differing from conventional antigens in the T cell receptor (TCR) requirements for their recognition, in the signal transduction events which they elicit in T cells, and in the identity of the stimulatory ligand. This review describes recent findings indicating that TCR V alpha as well as V beta products play a role in Mls recognition. Data are also summarized which indicate that T cell recognition of Mls leads to increased intracellular [Ca2+] and phosphatidyl inosotol hydrolysis. Finally, genetic linkage between mouse mammary tumor virus (MMTV) proviruses and endogenous superantigens is analyzed, and the possible role of non-MMTV products is examined.
Hodes
R J
RJ
Experimental Immunology Branch, National Cancer Institute, Bethesda, MD 20892.
Abe
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D000818:Animals; D001853:Bone Marrow / Q000276:immunology; D002118:Calcium / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation; D008297:Male; D008324:Mammary Tumor Virus, Mouse / Q000276:immunology; D051379:Mice; D016747:Minor Lymphocyte Stimulatory Antigens / Q000276:immunology*; D011533:Proviruses / Q000276:immunology; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000096:biosynthesis*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*
D016747:Minor Lymphocyte Stimulatory Antigens; D016693:Receptors, Antigen, T-Cell, alpha-beta; D002118:Calcium