title: Metabolic aspects of acute tissue hypoxia during extracorporeal circulation and their modification induced by L-carnitine treatment.
abstract: In this study the authors examine the effects of acute hypoxia due to extracorporeal circulation (ECC) and the role played by L-carnitine treatment on some plasmatic metabolites linked to glycolytic cellular metabolism. To obtain biochemical data, 120 patients in extracorporeal circulation during aortopulmonary bypass surgery were evaluated. The patients received either sodium bicarbonate (40 patients), or L-carnitine during ECC (40 patients) or before and during ECC (40 patients), and plasma samples were collected before ECC, during ECC and after ECC. The levels of lactate and pyruvate showed significant alterations in sodium bicarbonate-treated patients, and there was also a considerable imbalance in the succinate/fumarate ratio. This means that tissue hypoxia due to ECC leads to cellular oxidative damage and to a considerable decrease in the intracellular energy pools. The use of L-carnitine antagonizes the oxidative stress, as is well documented by the levels of plasmatic metabolites which remain confined to normal amounts.
authors.affiliation: Institute of Anesthesia and Intensive Care, University of Cagliari, Italy.
authors.forename: G G
authors.initials: GG
authors.lastname: Corbucci
authors.forename: A
authors.initials: A
authors.lastname: Menichetti
authors.forename: A
authors.initials: A
authors.lastname: Cogliatti
authors.forename: P
authors.initials: P
authors.lastname: Nicoli
authors.forename: C
authors.initials: C
authors.lastname: Ruvolo
mesh_terms: D001639:Bicarbonates / Q000494:pharmacology; D002331:Carnitine / Q000494:pharmacology* / Q000627:therapeutic use; D004311:Double-Blind Method; D005112:Extracorporeal Circulation; D005260:Female; D005650:Fumarates / Q000097:blood; D006801:Humans; D000860:Hypoxia / Q000097:blood* / Q000188:drug therapy; D007773:Lactates / Q000097:blood*; D019344:Lactic Acid; D008297:Male; D008875:Middle Aged; D011773:Pyruvates / Q000097:blood*; D011897:Random Allocation; D012964:Sodium / Q000494:pharmacology; D017693:Sodium Bicarbonate; D013386:Succinates / Q000097:blood; D019802:Succinic Acid
chemical_list: D001639:Bicarbonates; D005650:Fumarates; D007773:Lactates; D011773:Pyruvates; D013386:Succinates; D019344:Lactic Acid; C032005:fumaric acid; D017693:Sodium Bicarbonate; D012964:Sodium; D019802:Succinic Acid; D002331:Carnitine