Inhibition by squalene of the tumor-promoting activity of 12-O-tetradecanoylphorbol-13-acetate in mouse-skin carcinogenesis.
Squalene inhibited the effect of tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), such as increased 32Pi incorporation into phospholipids of HeLa cell membrane, induction of Epstein-Barr-virus early antigen in Raji cell and induction of ornithine decarboxylase in mouse skin. Squalene also markedly suppressed the promoting activity of TPA on skin carcinogenesis in 7,12-dimethylbenz[a]anthracene-initiated mice.
Murakoshi
M
M
Department of Biochemistry, Kyoto Prefectural University of Medicine, Japan.
Nishino
H
H
Tokuda
H
H
Iwashima
A
A
Okuzumi
J
J
Kitano
H
H
Iwasaki
R
R
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000956:Antigens, Viral / Q000187:drug effects; D002460:Cell Line; D004790:Enzyme Induction / Q000187:drug effects; D006367:HeLa Cells; D004854:Herpesvirus 4, Human / Q000187:drug effects / Q000276:immunology; D006801:Humans; D008563:Membrane Lipids / Q000378:metabolism; D051379:Mice; D009955:Ornithine Decarboxylase / Q000187:drug effects; D010743:Phospholipids / Q000378:metabolism; D012878:Skin Neoplasms / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D013185:Squalene / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000031:analogs & derivatives; D014775:Virus Activation / Q000187:drug effects
D016588:Anticarcinogenic Agents; D000956:Antigens, Viral; C033305:Epstein-Barr virus early antigen; D008563:Membrane Lipids; D010743:Phospholipids; C032975:12-O-tetradeca-2,4,6,8-tetranoylphorbol-13-acetate; D013185:Squalene; D009955:Ornithine Decarboxylase; D013755:Tetradecanoylphorbol Acetate