Antisense oligonucleotides: inhibition of liver cell proliferation and in vivo disposition.
As oligomers inhibited hepatoma growth in vitro. These cells have oligomer-specific binding sites. The oligomers were taken up by liver and have potential for hepatic growth modulation in intact animals.
Inagaki
M
M
Department of Surgery, University of Pittsburgh, Pennsylvania 15261.
Togawa
K
K
Carr
B I
BI
Ghosh
K
K
Cohen
J S
JS
D000818:Animals; D006528:Carcinoma, Hepatocellular; D002455:Cell Division / Q000187:drug effects*; D002461:Cell Line, Transformed; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D008099:Liver / Q000166:cytology*; D008113:Liver Neoplasms; D016376:Oligonucleotides, Antisense / Q000494:pharmacology*; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism; D051381:Rats; D016212:Transforming Growth Factor beta / Q000378:metabolism
D016376:Oligonucleotides, Antisense; D016271:Proto-Oncogene Proteins c-myc; D016212:Transforming Growth Factor beta