The in vitro profile of selected 14-membered azalides.
The in vitro antimicrobial potency of 10-aza-9-deoxo-11-deoxyerythromycin A, the first member of a new class of macrolide antibiotic, was determined. Several other members of this family of azalide were prepared and similarly screened in order to begin to define the antibiotic potential of the class. The results indicate that the SAR for this structural type parallels that of other macrolides and that it offers no apparent benefit over known 15-membered azalides.
Jones
A B
AB
Synthetic Chemical Research Department, Merck Research Laboratories, Rahway, NJ 07065.
Herbert
C M
CM
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D017963:Azithromycin; D001419:Bacteria / Q000187:drug effects*; D004917:Erythromycin / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D018942:Macrolides; C078857:10-aza-10-demethyl-9-deoxo-11-deoxyerythromycin A; D004917:Erythromycin; D017963:Azithromycin