Novel method for evaluating antiviral drugs against human cytomegalovirus in mice.
A virus-host cell system in which human cytomegalovirus-infected human cells are entrapped in agarose plugs has been developed. This model provides an inexpensive method for the in vivo evaluation (with outbred, immunocompetent mice) of antiviral drugs against human viruses such as cytomegalovirus that replicate primarily or only in human cells.
Allen
L B
LB
Southern Research Institute, Birmingham, Alabama 35255.
Li
S X
SX
Arnett
G
G
Toyer
B
B
Shannon
W M
WM
Hollingshead
M G
MG
D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000187:drug effects; D003586:Cytomegalovirus Infections / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D015774:Ganciclovir / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D015774:Ganciclovir