Mechanisms of immune protection in the asexual blood stage infection by Plasmodium falciparum: analysis by in vitro and ex-vivo assays.
Mechanisms of immune protection against the asexual blood stage infection by Plasmodium falciparum are reviewed. Recent studies of two independent lines of research developed at the Institut Pasteur, in humans and primate infections clearly indicate an obligatory interaction of antibodies and effector cells to express the anti-parasitic effect.
Gysin
J
J
Laboratorie d'immunoparasitologie, Institut Pasteur, Paris, France.
Druilhe
P
P
Da Silva
L P
LP
D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000276:immunology; D000920:Antibody-Dependent Cell Cytotoxicity; D002648:Child; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D016778:Malaria, Falciparum / Q000276:immunology*; D009895:Opsonin Proteins / Q000276:immunology; D010587:Phagocytosis; D010963:Plasmodium falciparum / Q000254:growth & development / Q000276:immunology*; D011961:Receptors, Fc / Q000276:immunology; D012453:Saimiri / Q000469:parasitology
D000913:Antibodies, Protozoan; D007074:Immunoglobulin G; D009895:Opsonin Proteins; D011961:Receptors, Fc