Stimulation of host-defense mechanism with synthetic adjuvants and recombinant cytokines against viral infection in mice.
The efficacy of synthetic immunoadjuvants and recombinant cytokines for the potentiation of host-resistance against virus infection was investigated using mouse models infected with Sendai virus and herpes simplex type 1 virus (HSV). The synthetic MDP derivative, MDP-Lys(L18), and recombinant cytokines, IL-1 beta, IFN-gamma, G-CSF and GM-CSF were shown to be effective for the stimulation of nonspecific protection against Sendai virus infection in mice. Both MDP-Lys(L18) and GM-CSF were effective for the protection against HSV infection in cyclophosphamide (CY)-treated mice. B30-MDP was suggested to be useful as an immunoadjuvant for the potentiation of antigenicity of recombinant or component vaccines.
Azuma
I
I
Institute of Immunological Science, Hokkaido University, Sapporo, Japan.
Ishihara
C
C
Iida
J
J
Yoo
Y C
YC
Yoshimatsu
K
K
Arikawa
J
J
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000595:Amino Acid Sequence; D000818:Animals; D016207:Cytokines / Q000494:pharmacology*; D006476:Orthohantavirus / Q000276:immunology; D006561:Herpes Simplex / Q000276:immunology / Q000517:prevention & control; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D010222:Parainfluenza Virus 1, Human; D018184:Paramyxoviridae Infections / Q000276:immunology / Q000517:prevention & control; D014759:Viral Envelope Proteins / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology / Q000517:prevention & control*
D000276:Adjuvants, Immunologic; D016207:Cytokines; D014759:Viral Envelope Proteins; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C036866:romurtide