title: Fibrous dysplasia with locally aggressive malignant change.
abstract: This is a case report of a tumour which showed all the histological features of fibrous dysplasia without any features of high-grade malignancy, yet had become locally aggressive, causing cortical erosion and extension into soft tissue. Fibrous dysplasia is a well-recognised entity that encompasses monostotic lesions, polyostotic involvement and Albright's syndrome [6, 8]. Lesions in bone usually spare the epiphysis before puberty, but often involve the epiphyseal area after maturity and can progress during adult life [3]. Unless cystic [6, 10] or malignant change [7, 10, 11] occurs, fibrous dysplasia usually remains contained within bone.
authors.affiliation: Nuffield Department of Orthopaedic Surgery, Nuffield Orthopaedic Centre, Headington, Oxford, UK.
authors.forename: P D
authors.initials: PD
authors.lastname: Latham
authors.forename: N A
authors.initials: NA
authors.lastname: Athanasou
authors.forename: C G
authors.initials: CG
authors.lastname: Woods
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D005357:Fibrous Dysplasia of Bone / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology; D006801:Humans; D008637:Mesenchymoma / Q000473:pathology; D012516:Osteosarcoma / Q000473:pathology; D011859:Radiography; D012785:Shoulder Joint / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery