[Antiarrhythmic effects of kappa-seleno-carrageenan in experimental animals].
The effect of Kappa-seleno-carrageenan, an organic compound containing selenium, on aconitine, BaCl2 and ouabain-induced arrhythmias were studied. When rats were given ip 9 mg.kg-1.d-1 x 5 d or ig single dose of 35, 70, 140 mg.kg-1, the threshold dose of aconitine was elevated significantly to induce HA. The effect seems to resemble that of ip Na2SeO3 1 mg.kg-1 x d-1 x 5 d. With increasing ig dose, the threshold dose of aconitine was elevated for inducing VE, VT, VF. When ip 9 mg.kg-1 x d-1 x 5 d or ig 70 mg.kg-1 was given, the threshold doses of BaCl2 in inducing VF (in rats) and ouabain in inducing VE (in guinea-pig) were elevated. However, no influence was observed for ip Na2SeO3 1 mg.kg-1 x d-1 x 5 d.
Li
D
D
Department of Pharmacology, School of Pharmacy, Shanghai Medical University.
Yang
X Y
XY
Han
Q
Q
Xi
B B
BB
Xie
P
P
Lin
Z J
ZJ
D000157:Aconitine; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control*; D001464:Barium; D017609:Barium Compounds; D002351:Carrageenan / Q000627:therapeutic use*; D002712:Chlorides; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D016566:Organoselenium Compounds / Q000627:therapeutic use*; D010042:Ouabain; D051381:Rats; D012643:Selenium / Q000627:therapeutic use; D018038:Sodium Selenite
D000889:Anti-Arrhythmia Agents; D017609:Barium Compounds; D002712:Chlorides; D016566:Organoselenium Compounds; C079969:kappa-selenocarrageenan; C024986:barium chloride; D001464:Barium; D010042:Ouabain; D002351:Carrageenan; D012643:Selenium; D018038:Sodium Selenite; D000157:Aconitine