title: Follow-up evaluation of cervicovaginal human papillomavirus infection in adolescents.
abstract: We performed a second examination for human papillomavirus (HPV) DNA on 51 sexually experienced 13- to 21-year-old (mean = 17.8 years) female patients seen at an urban teaching hospital. Cervicovaginal lavages were performed 6 to 36 months apart (median = 13.3 months) to collect cells for HPV DNA detection and typing by Southern blot hybridization. At the first and second visits, 39.2% (20/51) and 25.5% (13/51) of patients, respectively, were infected with HPV. Collectively, 56.9% (29/51) of patients had at least one positive HPV test result. Although 7.8% (4/51) were infected with HPV at both visits, only one patient had infection with the same HPV type. These findings suggest that although HPV infection is a common sexually transmitted disease, genotype-specific HPV infection detected by Southern blot at two visits was rare.
authors.affiliation: Department of Pediatrics, Montefiore Medical Center-Albert Einstein College of Medicine, Bronx, New York.
authors.forename: W D
authors.initials: WD
authors.lastname: Rosenfeld
authors.forename: E
authors.initials: E
authors.lastname: Rose
authors.forename: S H
authors.initials: SH
authors.lastname: Vermund
authors.forename: K
authors.initials: K
authors.lastname: Schreiber
authors.forename: R D
authors.initials: RD
authors.lastname: Burk
mesh_terms: D000293:Adolescent; D000328:Adult; D015139:Blotting, Southern; D002584:Cervix Uteri / Q000382:microbiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D009518:New York / Q000453:epidemiology; D027383:Papillomaviridae / Q000145:classification / Q000302:isolation & purification*; D012725:Sexual Behavior; D014412:Tumor Virus Infections / Q000453:epidemiology / Q000382:microbiology*; D014621:Vagina / Q000382:microbiology*