Recent advances and prospective researches on molecular epidemiology of dengue viruses.
The determination of amino acid changes in the envelope protein by direct sequencing of either genomic RNA or PCR-amplified cDNA fragments provides useful informations for assessing the genetic variability and the geographic distribution of the actually most widespread dengue-2 serotype. The possible link of variations in the envelope protein-gene and virus virulence is discussed.
Deubel
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Laboratory of Arboviruses, Institut Pasteur, Paris, France.
D003715:Dengue / Q000453:epidemiology / Q000382:microbiology*; D003716:Dengue Virus / Q000235:genetics*; D005838:Genotype; D006801:Humans