The management of pediatric brain tumors in a tertiary center.
Between January 1982 and January 1990, 120 newly diagnosed pediatric patients were treated at The Chaim Sheba Medical Center. Sixty three (52.5%) tumors arose in the posterior fossa and 57 (47.5%) appeared supratentorially. A wide variety of histologic subtypes was seen, each requiring tumor-specific treatment. The modern imaging techniques-CT and MRI-offered better planning of operation, treatment and follow up. All children with highly malignant tumors were treated with combination chemotherapy besides the 'conventional radiotherapy'. Since 1987 the "eight in one day" protocol has been used extensively pre- and post-irradiation. Five-year survival, varied significantly according to tumor type, location and stage. The average delay from presentation of symptoms to diagnosis was 6 months. A multidisciplinary approach has been used in the treatment, rehabilitation and follow-up of these children. In this study, the results of treatment are presented and the role of chemotherapy is discussed.
Mandel
M
M
Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Toren
A
A
Findler
G
G
Neumann
Y
Y
Kende
G
G
Faibel
M
M
Tadmor
R
R
Brenner
H
H
Sahar
A
A
Ramot
B
B
D000293:Adolescent; D001254:Astrocytoma / Q000628:therapy; D001932:Brain Neoplasms / Q000473:pathology / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D008527:Medulloblastoma / Q000628:therapy; D018242:Neuroectodermal Tumors, Primitive / Q000628:therapy