[Specific inhibition by ATP of histamine-stimulated acid secretion in the gastric glands of the rabbit].
The influence of adenosine 5'-triphosphate on gastric acid secretion stimulated by histamine, carbachol, dibutyryl-cAMP and the phosphodiesterase inhibitors 8-phenyl-theophylline and rolipram in isolated rabbit gastric glands was studied. Changes oi gastric acid secretion were measured by the aminopyrine accumulation method. Histamine-stimulated acid secretion was significantly inhibited by ATP 1 mM, whereas the secretory responses elicited by carbachol, dibutyryl-cAMP, 8-phenyl-theophylline or rolipram were not. Assays with indomethacin, a well known prostaglandin synthesis inhibitor, showed that this agent significantly reduced the inhibitory effect of ATP on histamine responses. The results indicate that the antisecretory effect of ATP was specific for histamine and that it was mediated, at least in part, via stimulation of endogenous prostaglandin production.
Gil-Rodrigo
C E
CE
Departamento de Fisiología, Facultad de Medicina y Odontología, Universidad del País Vasco (UPV-EHU), Bilbao, España.
Gáldiz
B
B
Carou
M
M
Gandarias
J M
JM
Gómez
R
R
Vallejo
A
A
Ainz
L F
LF
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D003864:Depression, Chemical; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology*; D006633:Histamine Antagonists / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D011453:Prostaglandins / Q000096:biosynthesis; D011760:Pyrrolidinones / Q000494:pharmacology; D011817:Rabbits; D020889:Rolipram; D012636:Secretory Rate / Q000187:drug effects; D013806:Theophylline / Q000031:analogs & derivatives / Q000494:pharmacology
D006633:Histamine Antagonists; D011453:Prostaglandins; D011760:Pyrrolidinones; D003994:Bucladesine; D006632:Histamine; D000255:Adenosine Triphosphate; D002217:Carbachol; D013806:Theophylline; C028322:8-phenyltheophylline; D020889:Rolipram; D007213:Indomethacin
Inhibición específica por ATP de la secreción ácida estimulada por histamina en glándulas gástricas de conejo.