title: Irradiation increases proteolysis in erythrocyte ghosts: a spin label study.
abstract: X- and gamma-irradiation of human erythrocyte membranes (250-1000 Gy) was found to decrease the ratio of weakly to strongly immobilized signal height of membrane-bound maleimide spin label (Mal-6). Subsequent incubation of spin-labeled membranes at ambient temperature (21 degrees C) induced a progressive increase in this ratio, faster for membranes irradiated with low doses which was hampered by protease inhibitors. These results demonstrate that ionizing radiation stimulates proteolysis of erythrocyte membrane proteins by membrane-associated proteases.
authors.affiliation: Department of Biophysics, University of Lodz, Poland.
authors.forename: G
authors.initials: G
authors.lastname: Bartosz
authors.forename: W
authors.initials: W
authors.lastname: Schön
authors.forename: G
authors.initials: G
authors.lastname: Kraft
authors.forename: H
authors.initials: H
authors.lastname: Gärtner
mesh_terms: D001798:Blood Proteins / Q000378:metabolism / Q000528:radiation effects*; D004578:Electron Spin Resonance Spectroscopy; D004910:Erythrocyte Membrane / Q000378:metabolism / Q000528:radiation effects*; D005720:Gamma Rays; D006801:Humans; D013113:Spin Labels
chemical_list: D001798:Blood Proteins; D013113:Spin Labels