Glutathione inhibits replication and expression of viral proteins in cultured cells infected with Sendai virus.
Addition of reduced glutathione inhibited the production of Sendai virus in African green monkey kidney (AGMK) cells. This result could be accounted for by a direct action of GSH on viral replication. The inhibitory action was associated to an increase of the GSH intracellular level, while the host cell metabolism was unaffected. The antiviral effect was related to decrease and inactivation of the hemagglutinin-neuraminidase (HN) virus glycoprotein.
Garaci
E
E
Department of Experimental Medicine and Biochemical Sciences, University of Rome, Tor Vergata, Italy.
Palamara
A T
AT
Di Francesco
P
P
Favalli
C
C
Ciriolo
M R
MR
Rotilio
G
G
D000818:Animals; D002478:Cells, Cultured; D004279:DNA, Viral / Q000096:biosynthesis; D005978:Glutathione / Q000378:metabolism / Q000494:pharmacology*; D010222:Parainfluenza Virus 1, Human / Q000187:drug effects* / Q000254:growth & development; D012367:RNA, Viral / Q000096:biosynthesis; D014764:Viral Proteins / Q000096:biosynthesis*; D014779:Virus Replication / Q000187:drug effects*
D004279:DNA, Viral; D012367:RNA, Viral; D014764:Viral Proteins; D005978:Glutathione