Evidence that nitric oxide mediates the cyclic GMP response to synaptic activity in the rat superior cervical ganglion.
Preganglionic nerve stimulation in the rat superior cervical ganglion (SCG) caused an increase in guanosine 3':5'-cyclic monophosphate (cyclic GMP) in a Ca(2+)-dependent manner. This increase was inhibited by oxyhaemoglobin, and blocked stereoselectively by an inhibitor of nitric oxide synthase, NG-nitro-L-arginine. Thus, nitric oxide or a similar substance appears to mediate the neuronal cyclic GMP response to synaptic activity in the rat SCG.
Sheng
H
H
Signal Transduction, Abbott Laboratories, IL 60064.
Hughes
M L
ML
Murad
F
F
Briggs
C A
CA
D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D006152:Cyclic GMP / Q000378:metabolism*; D004558:Electric Stimulation; D005728:Ganglia, Sympathetic / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D019335:Nitroarginine; D010108:Oxyhemoglobins / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013569:Synapses / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*
D010108:Oxyhemoglobins; D019335:Nitroarginine; D009569:Nitric Oxide; D001120:Arginine; D006152:Cyclic GMP