Synthesis, characterization and biodistribution of the cationic technetium(II) 1,10-phenanthroline chelate.
[99Tc(phen)3]Cl2 was synthesized by reduction of pertechnetate with sodium borohydride in the presence of an excess of 1,10-phenanthroline and characterized by FAB mass spectrometry, magnetic susceptibility measurements, and i.r./vis/u.v. spectrophotometry. For biodistribution evaluation in mice [99mTc(phen)3]Cl2 could be obtained in a radiochemical purity of 92.5% using a similar procedure. The rather hydrophilic chelate was predominantly excreted by the kidneys. Its low blood retention resulted in a heart/blood activity ratio of 4.2 at 100 min post-injection.
Schwochau
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K
Institut für Chemie 1 (Nuklearchemie), Forschungszentrum Jülich GmbH (KFA), Germany.
Linse
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KH
Su
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D000818:Animals; D051379:Mice; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D010618:Phenanthrolines / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014018:Tissue Distribution
D015609:Organotechnetium Compounds; D010618:Phenanthrolines; C078195:technetium Tc 99m 1,10-phenanthroline