[The behavior of serum angiotensin-converting enzyme in normotensive subjects, in subjects with essential hypertension and in subjects with primary hyperaldosteronism on the orthostatic test].
The results of this study demonstrate that only in healthy normotensive subjects during extended orthostatism that the renin-angiotensin-aldosterone system remains integral and is characterized by a significant increase in serum angiotensin-converting enzyme (SACE), plasma renin activity (PRA) and plasma aldosterone (PA). SACE modification do not seems to directly follow that of PRA (as shown by the absence of a direct correlation between SACE and PRA). In essential hypertension, the behavior of SACE seems to change, without demonstrating a significant increase in the mean levels of this enzyme. Finally in hypertension of known origin, such as primary hyperaldosteronism, the low levels of SACE in the recumbent position (not stimulated by orthostatism) seem to depend (by mechanism of negative biofeedback) on the increased serum levels of PA, which is moreover verified in the same group for PRA.
Letizia
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I Patologia Medica, Università degli Studi di Roma La Sapienza.
Cerci
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S
De Ciocchis
A
A
Tarsitani
P
P
D'Ambrosio
C
C
Coassin
S
S
Scavo
D
D
D000328:Adult; D000450:Aldosterone / Q000097:blood; D001510:Bed Rest; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood*; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood*; D011187:Posture / Q000502:physiology*; D012016:Reference Values; D012083:Renin / Q000097:blood; D013997:Time Factors
D000450:Aldosterone; D007703:Peptidyl-Dipeptidase A; D012083:Renin
Il comportamento del serum angiotensin converting enzyme in soggetti normotesi ed in soggetti con ipertensione essenziale ed in soggetti con iperaldosteronismo primario alla prova dell'ortostatismo.