3-Phenyl-4-hydroxyquinolin-2(1H)-ones: potent and selective antagonists at the strychnine-insensitive glycine site on the N-methyl-D-aspartate receptor complex.
McQuaid
L A
LA
Lilly Research Laboratories, Division of Eli Lilly and Company Corporate Center, Indianapolis, Indiana 46285.
Smith
E C
EC
Lodge
D
D
Pralong
E
E
Wikel
J H
JH
Calligaro
D O
DO
O'Malley
P J
PJ
D000818:Animals; D001665:Binding Sites; D005998:Glycine / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015363:Quinolones / Q000494:pharmacology*; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013331:Strychnine / Q000494:pharmacology*
D015363:Quinolones; D016194:Receptors, N-Methyl-D-Aspartate; D013331:Strychnine; D005998:Glycine