title: Alpha-2-adrenoceptor sensitivity in early alcohol withdrawal.
abstract: Growth hormone (GH), blood pressure, and pulse rate responses to clonidine (100 micrograms IV) were studied three times during the first week of alcohol withdrawal in 19 alcohol-dependent patients. Fifteen healthy men were used as controls. The results suggest reduced sensitivity of the alpha-2-adrenoceptors involved in GH secretion for at least 1 week after the end of alcohol intake. In contrast, very short-lasting subsensitivity was found in the alpha-2-adrenoceptors regulating blood pressure.
authors.affiliation: Department of Psychiatry and Neurochemistry, University of Göteborg, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Balldin
authors.forename: U
authors.initials: U
authors.lastname: Berggren
authors.forename: J
authors.initials: J
authors.lastname: Engel
authors.forename: G
authors.initials: G
authors.lastname: Lindstedt
authors.forename: A
authors.initials: A
authors.lastname: Sundkler
authors.forename: J
authors.initials: J
authors.lastname: Wålinder
mesh_terms: D000328:Adult; D000430:Alcohol Withdrawal Delirium / Q000188:drug therapy / Q000503:physiopathology*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D002719:Chlormethiazole / Q000627:therapeutic use; D002749:Chlorprothixene / Q000627:therapeutic use; D003000:Clonidine; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000502:physiology*; D010076:Oxazepam / Q000627:therapeutic use; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology*
chemical_list: D011941:Receptors, Adrenergic; D002719:Chlormethiazole; D010076:Oxazepam; D013006:Growth Hormone; D002749:Chlorprothixene; D003000:Clonidine; D009638:Norepinephrine