[Re-examination of the role of mast cells, mediators of inflammation and heparin].
Mast cells contain proteoglycans, e.g. heparin, which manifest potent anti-inflammatory features. Mast cell degranulation could eventually result in self limiting inflammation with shortened course due to heparin release. The recent availability of low molecular weight heparins will allow for clinical studies in allergic/inflammatory syndromes, e.g. asthma.
Halpern
G M
GM
Department of Internal Medicine, UCD School of Medicine 95616.
D000893:Anti-Inflammatory Agents / Q000276:immunology; D001249:Asthma / Q000276:immunology; D006493:Heparin / Q000276:immunology*; D006495:Heparin, Low-Molecular-Weight / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007249:Inflammation / Q000276:immunology*; D008407:Mast Cells / Q000276:immunology*
D000893:Anti-Inflammatory Agents; D006495:Heparin, Low-Molecular-Weight; D006493:Heparin
Réexamen du rôle des mastocytes, des médiateurs de l'inflammation et de l'héparine.