Evaluation of temafloxacin in a rat model of intra-abdominal abscess.
The in-vitro activity of temafloxacin, a new fluoroquinolone, was evaluated in an experimental model of intra-abdominal abscess in rats. Mixed aerobic-anaerobic infection was induced by intraperitoneal implantation of gelatin capsules containing Bacteroides fragilis, Escherichia coli, and sterile rat faeces. Temafloxacin was highly active with a 90.9% cure rate in comparison with no treatment (no cures; P less than 0.0001), and as active as a combination of clindamycin and gentamicin (100% cure rate; P greater than 0.05). Temafloxacin (12 mg/dose) gave rise to serum concentrations that exceeded the MIC values of both microorganisms for at least 8 h.
Thadepalli
H
H
Department of Medicine and Pathology, Drew University School of Medicine and Science, Los Angeles, California.
Hajji
M
M
Perumal
V K
VK
Chuah
S K
SK
Gollapudi
S
S
D000005:Abdomen; D000038:Abscess / Q000188:drug therapy* / Q000382:microbiology; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001442:Bacteroides Infections / Q000188:drug therapy* / Q000382:microbiology; D001441:Bacteroides fragilis; D002981:Clindamycin / Q000627:therapeutic use; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000382:microbiology; D005243:Feces / Q000382:microbiology; D024841:Fluoroquinolones; D005839:Gentamicins / Q000627:therapeutic use; D008297:Male; D015363:Quinolones / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D005839:Gentamicins; D015363:Quinolones; C054745:temafloxacin; D002981:Clindamycin