Evidence for a lentiviral etiology in an epizootic of immune deficiency and lymphoma in stump-tailed macaques (Macaca arctoides).
A retrospective study determined that an epizootic of immune suppression and lymphoma in stump-tailed macaques (Macaca arctoides) that began in 1976 was associated with a horizontally spread lentivirus infection. This conclusion was based on serology, epidemiology, pathology, and virus isolation. The lesions found in the stump-tailed macaques were more compatible with lesions seen in SIV-infected rhesus than those seen in rhesus macaques infected with type D retroviruses. A lentivirus, isolated from a rhesus inoculated with lymph node homogenate from a stump-tailed macaque, was designed SIVstm and was pathogenic for rhesus macaques. The isolate was antigenically related to other SIVs as well as to HIV-1 and HIV-2. Two surviving stump-tailed macaques sent to another colony carried SIVstm latently for at least 7 years and disseminated it throughout that colony.
Lowenstine
L J
LJ
Department of Pathology, School of Veterinary Medicine, University of California, Davis 95616.
Lerche
N W
NW
Yee
J L
JL
Uyeda
A
A
Jennings
M B
MB
Munn
R J
RJ
McClure
H M
HM
Anderson
D C
DC
Fultz
P N
PN
Gardner
M B
MB
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D015153:Blotting, Western; D004196:Disease Outbreaks / Q000662:veterinary*; D015497:HIV-1 / Q000276:immunology; D015498:HIV-2 / Q000276:immunology; D015368:Human T-lymphotropic virus 1 / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000382:microbiology / Q000648:ultrastructure; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000150:complications / Q000662:veterinary*; D008251:Macaca; D008992:Monkey Diseases / Q000453:epidemiology / Q000382:microbiology*; D012189:Retrospective Studies; D015301:Retroviruses, Simian / Q000276:immunology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000150:complications / Q000453:epidemiology / Q000382:microbiology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology / Q000302:isolation & purification / Q000648:ultrastructure; D014771:Virion / Q000648:ultrastructure
D000914:Antibodies, Viral