Effects of some GABAergic agents on quinine-induced seizures in mice.
The effects of some GABAergic agents on seizures induced by quinine were studied in mice. Muscimol, AOAA, DABA and baclofen significantly protected mice against quinine-induced convulsions. Bicuculline effectively enhanced quinine-induced convulsions, and significantly attenuated the protective effects of muscimol, AOAA and DABA against convulsions induced by quinine. Diazepam and phenobarbitone significantly protected mice against convulsions induced by quinine. However, phenytoin did not affect quinine-induced seizures to any significant degree. These results indicate that the convulsant effect of quinine may be due to a disturbance in the status of the GABAergic system.
Amabeoku
G J
GJ
Department of Clinical Pharmacology, Medical School, University of Zimbabwe, Avondale, Harare.
Chikuni
O
O
D000613:Aminobutyrates / Q000494:pharmacology; D000625:Aminooxyacetic Acid / Q000494:pharmacology; D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D001640:Bicuculline / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009118:Muscimol / Q000494:pharmacology; D010634:Phenobarbital / Q000494:pharmacology; D010672:Phenytoin / Q000494:pharmacology; D011803:Quinine / Q000633:toxicity*; D011963:Receptors, GABA-A / Q000187:drug effects*; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*
D000613:Aminobutyrates; D011963:Receptors, GABA-A; D000625:Aminooxyacetic Acid; D009118:Muscimol; C005959:2,4-diaminobutyric acid; D010672:Phenytoin; D011803:Quinine; D001418:Baclofen; D003975:Diazepam; D001640:Bicuculline; D010634:Phenobarbital