Human herpesvirus-6 infection and bone marrow transplantation.
Human herpesvirus-6 (HHV-6) is ubiquitous in the human population and causes exanthem subitum, a benign disease seen in infancy. However it also produces a wide spectrum of clinical manifestations including cases with a fatal outcome. The virus remains latent in several organs, including the kidneys, liver, lymph/nodes and salivary glands, after the primary infection and reactivates when immune function is impaired. Reactivation of the virus occurred in a half of the bone marrow recipients 2 to 4 weeks after bone marrow transplantation (BMT). It remains to be established whether HHV-6 in fact causes the fever and rash observed in recipients who have reactivation of the virus. The data reviewed here will be required to compare with those of human herpesvirus 7 and a different group of HHV-6.
Yoshikawa
T
T
Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Japan.
Kojima
S
S
Asano
Y
Y
D000293:Adolescent; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D003095:Collagen Diseases / Q000382:microbiology; D005260:Female; D006566:Herpesviridae Infections / Q000635:transmission*; D015654:Herpesvirus 6, Human / Q000302:isolation & purification; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D008223:Lymphoma / Q000382:microbiology; D008297:Male; D014775:Virus Activation