[Relation between female genital human papilloma virus (HPV) infection and cancer of uterine cervix in Xiang Yuan County, a high incidence area of cervical carcinoma].
Six thousand seven hundred and ten women were screened in a high incidence area, Xiang Yuan County, Shanxi province to study the relation between cervical cancer and female genital HPV infection (HPVI). Invasive cervical cancer was diagnosed by histopathology in 15 subjects, CIS in 44 and HPVI in 110. Morphologic features of HPVI were found in 23.9% (80/334) of the biopsies from abnormal cervix and lower genital tract. A total of 20.3% lesions had morphologic feature of HPVI associated with CIN, CIS and ICC. One hundred sixty eight biopsies were assayed for the presence of HPV 6B/11, 16, 18 DNA by dot blot hybridization. Altogether, 40.5% biopsies were found to have HPV DNA. The positivities of HPV DNA in cancerous and non-cancerous groups were 62.8% and 32.8%, respectively. The positivity of HPV DNA and the grade of cervical lesions showed a statistically significant correlation (P less than 0.01). Of those with positive HPV DNA HPV 16 was the most frequent type (66.2%). This study further demonstrated that Xiang Yuan is one of the highest risk areas of cervical cancer in China. It is suggested that there is a close association between cervical cancer and HPV infection, especially of type HPV 16, of the female genital tract.
Wu
A R
AR
Cancer Hospital, Chinese Academy of Medical Sciences, Beijing.
D000328:Adult; D002278:Carcinoma in Situ / Q000382:microbiology*; D002681:China / Q000453:epidemiology; D015344:DNA Probes, HPV; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged; D027383:Papillomaviridae; D011230:Precancerous Conditions / Q000382:microbiology; D015995:Prevalence; D014412:Tumor Virus Infections / Q000453:epidemiology*; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000382:microbiology*
D015344:DNA Probes, HPV; D004279:DNA, Viral