title: Immunohistological study of grumose degeneration of the dentate nucleus in progressive supranuclear palsy.
abstract: The grumose degeneration observed in the dentate nuclei of 7 cases of progressive supranuclear palsy (PSP) was studied with a panel of antibodies which included 2 neurofilaments, Tau and ubiquitin. Dentate nucleus neurons were negative with all antibodies except ubiquitin which showed a slightly positive homogeneous pattern of staining. The amorphous material surrounding swollen or normal neurons was strongly positive for neurofilament and subunits and numerous torpedoes were observed in the granular layer of the cerebellar cortex. Our results confirm that grumose degeneration consists in degeneration of terminal axons of Purkinje cells in the dentate nucleus. The positivity of dentate nucleus neurons for ubiquitin may support the concept of synaptic dysfunction between Purkinje cells and dentate nucleus neurons.
authors.affiliation: Neurological Tissue Bank, Hospital Clinico y Provincial, University of Barcelona, Spain.
authors.forename: F F
authors.initials: FF
authors.lastname: Cruz-Sanchez
authors.forename: M L
authors.initials: ML
authors.lastname: Rossi
authors.forename: A
authors.initials: A
authors.lastname: Cardozo
authors.forename: A
authors.initials: A
authors.lastname: Picardo
authors.forename: E
authors.initials: E
authors.lastname: Tolosa
mesh_terms: D000368:Aged; D000906:Antibodies; D001369:Axons / Q000648:ultrastructure; D002525:Cerebellar Cortex / Q000473:pathology; D002531:Cerebellum / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009410:Nerve Degeneration; D009474:Neurons / Q000473:pathology*; D013494:Supranuclear Palsy, Progressive / Q000473:pathology* / Q000503:physiopathology; D014452:Ubiquitins / Q000032:analysis; D016875:tau Proteins / Q000032:analysis
chemical_list: D000906:Antibodies; D014452:Ubiquitins; D016875:tau Proteins