[Comparison of DNA analysis with histomorphologic parameters in stomach cancer].
After curative resection of stomach carcinomas (adenocarcinomas: n = 58, signet ring cell carcinomas: n = 24, undifferentiated carcinomas: n = 21) the DNA content of the tumor cells was compared with the histomorphological parameters. There was a correlation between the DNA content and the histomorphological parameters. The DNA analysis had no additionally prognostic influence. In the multivariate regression analysis the prognosis depended on lymph node status (p = 0.0009), pT-stage (p = 0.02), tumor localization (p = 0.03) and the histological type (p = 0.05). The prognosis was independent of the DNA content. Furthermore, neither did the degree of differentiation, the operative procedure, the safety distance, the size of the tumor, the sex nor the age of the patient have any influence on the prognosis.
Böttger
T
T
Klinik und Poliklinik für Allgemein- und Abdominalchirurgie, Johannes-Gutenberg-Universität, Mainz, BRD.
Gabbert
H
H
Stöckle
M
M
Wellek
S
S
Menke
H
H
Jauckus
H C
HC
Grenz
A
A
Heintz
A
A
Junginger
T
T
D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D002288:Adenocarcinoma, Mucinous / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D000782:Aneuploidy; D002277:Carcinoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D004273:DNA, Neoplasm / Q000032:analysis*; D004171:Diploidy; D005434:Flow Cytometry; D005743:Gastrectomy; D006801:Humans; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D015996:Survival Rate
D004273:DNA, Neoplasm
Vergleich der DNS-Analyse mit histomorphologischen Parametern beim Magenkarzinom.