Anti-HPA-4b (anti-Yuk(a)) neonatal alloimmune thrombocytopenia: first report in a Caucasian family.
Neonatal alloimmune thrombocytopenia (NAIT) is caused by platelet antigen incompatibility between the mother and fetus. NAIT is mainly due to alloimmunization; the frequency varying among ethnic groups. In Caucasians HPA-1a is the antigen most frequently implicated. In Japan, NAIT due to anti-HPA-4b antibody has already been described, but this is the first case to be reported in Caucasians.
Morel-Kopp
M C
MC
INTS, Service d'Immunologie Leucoplaquettaire, Paris, France.
Blanchard
B
B
Kiefel
V
V
Joly
C
C
Mueller-Eckhardt
C
C
Kaplan
C
C
D000328:Adult; D016824:Antigens, Human Platelet / Q000235:genetics / Q000276:immunology*; D005260:Female; D005787:Gene Frequency; D006650:Histocompatibility Testing; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007231:Infant, Newborn; D007518:Isoantibodies / Q000276:immunology*; D008297:Male; D010375:Pedigree; D010980:Platelet Membrane Glycoproteins / Q000235:genetics / Q000276:immunology*; D011247:Pregnancy; D013921:Thrombocytopenia / Q000151:congenital* / Q000235:genetics / Q000276:immunology; D044465:White People / Q000235:genetics
C510800:4b alloantigen, human; D016824:Antigens, Human Platelet; D007518:Isoantibodies; D010980:Platelet Membrane Glycoproteins