title: [Mid-term and long-term outcome in newborn infants with periventricular leukomalacia (53 cases)].
abstract: During the period 1983-1987, 53 neonates (30 boys, 23 girls, mean birth weight 1,438 +/- 317 g, mean gestational age 30 +/- 2 weeks) were found to have cystic periventricular leukomalacias (CPVL) detected by brain ultrasonography. The neuro-developmental follow-up was 3-7 years. Seventeen CPVL were isolated and CPVL were associated with minor peri-intraventricular hemorrhage (0-1 to II-II) in 36 cases. CPVL included 16 minor forms (11 normal children; 2 minor, 3 moderate sequelae), 29 moderate forms (15 normal children; 4 minor, 7 moderate, 3 major sequelae) and 8 major forms (7 major sequelae, one moderate mental retardation without motor deficit). According to reverse analysis, a normal evolution (26 cases) followed CPVL which were sometimes widely, but thinly spread over the ventricles (thickness 1/5-1/3 of the cerebral mantle); minor sequelae (6 cases) were associated with a 1/4-1/3 thickness, moderate sequelae (11 cases) with a 1/3-1/2 thickness, major sequelae (10 cases) with a 1/2-2/3 thickness of CPVL. The thickness of the lesions appeared to be more predictive of sequelae than the sagittal extent, in particular that of the posterior CPVL which played a major role in the severity of sequelae, and mainly in the presence of motor deficits.
authors.affiliation: Unité de soins intensifs néonatals de Port-Royal, centre hospitalier universitaire Cochin-Port-Royal-Tarnier, université René-Descartes, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Monset-Couchard
authors.forename: O
authors.initials: O
authors.lastname: de Bethmann
authors.forename: B
authors.initials: B
authors.lastname: Kastler
authors.forename: J P
authors.initials: JP
authors.lastname: Relier
mesh_terms: D002547:Cerebral Palsy / Q000503:physiopathology; D002657:Child Development; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007969:Leukomalacia, Periventricular / Q000503:physiopathology*; D008297:Male; D016896:Treatment Outcome
vernacular_title: Devenir à moyen et long terme des nouveau-nés atteints de leucomalacies périventriculaires (53 cas).