Activity of azithromycin (CP-62,993) and erythromycin against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum in vitro.
Several antibiotics, including the macrolide erythromycin and the azalides azithromycin (CP-62,993) and CP-63,956, that inhibit protein synthesis on 70S ribosomes demonstrated antimalarial effects in vitro against two strains of Plasmodium falciparum, one sensitive to chloroquine and the other resistant. In 48-hr incubations, erythromycin was 10-fold less potent than the azalides against the chloroquine-resistant strain. Erythromycin and the azalides were essentially equipotent against the chloroquine-sensitive strain. An additive effect occurred with the azalides in combination with chloroquine against both strains, but this was not seen with erythromycin.
Gingras
B A
BA
Department of Microbiology, Michigan State University, East Lansing.
Jensen
J B
JB
D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D017963:Azithromycin; D002738:Chloroquine / Q000494:pharmacology*; D004347:Drug Interactions; D004351:Drug Resistance; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*
D000981:Antiprotozoal Agents; C060737:CP 63956; D004917:Erythromycin; D017963:Azithromycin; D002738:Chloroquine