title: Familial Behçet's disease.
abstract: OBJECTIVE
  To highlight the frequency, clinical features and histocompatibility antigen types of the familial form of Behçet's disease.
  
  
  METHODS
  Twenty-seven cases with familial Behçet's disease in 12 families were evaluated according to clinical features, sites of involvement, HLA-A and HLA-B typing. A review of the literature is presented.
  
  
  RESULTS
  The frequency of familial form of Behçet's disease was found to be 8.7% among 137 patients studied. Vascular involvement was 7.4% (2/27) in the familial group while it was 28.8% (36/125) in patients without the familial form of the disease (p < 0.01). HLA-B51(5) and HLA-A2 were positive in 68% and 75% in 16 familial cases studied, respectively.
  
  
  CONCLUSIONS
  Familial Behçet's disease, which constitutes a small group of patients with Behçet's disease, may represent a clinically heterogeneous subtype of this entity. Although lower frequency of vascular complications was observed in this study, it is not possible to indicate the precise frequency of vascular and ocular complications of the familial form of Behçet's disease. The frequencies of HLA-A2 and HLA-B51(5) positivity are higher than the previously reported non-Behçet's controls from Turkey.
authors.affiliation: Department of Nephrology, Hacettepe University, Ankara, Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Akpolat
authors.forename: Y
authors.initials: Y
authors.lastname: Koç
authors.forename: I
authors.initials: I
authors.lastname: Yeniay
authors.forename: G
authors.initials: G
authors.lastname: Akpek
authors.forename: I
authors.initials: I
authors.lastname: Güllü
authors.forename: E
authors.initials: E
authors.lastname: Kansu
authors.forename: S
authors.initials: S
authors.lastname: Kiraz
authors.forename: F
authors.initials: F
authors.lastname: Ersoy
authors.forename: F
authors.initials: F
authors.lastname: Batman
authors.forename: T
authors.initials: T
authors.lastname: Kansu
mesh_terms: D000293:Adolescent; D000328:Adult; D001528:Behcet Syndrome / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D005260:Female; D015234:HLA-A Antigens / Q000032:analysis; D015235:HLA-B Antigens / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens