[The role of the sympathetic cholinergic pathway in the neurogenic control of the release of tissue-type plasminogen activator into the blood].
In anesthetized cats, electric stimulation of the sympathetic chain induced vasoconstriction and release of t-PA from the vascular wall into the blood. Efferent stimulation of the sympathetic chain against the background of alpha-adrenoceptor blockade increased the blood flow and the t-PA activity. Atropin suppressed both the vascular relaxation and the t-PA release into the blood. A neurogenous mechanism controlling t-PA release from the vascular wall caused by activation of sympathetic cholinergic pathway and associated with excitation of vascular M-cholinoreceptors by acetylcholine, has been suggested.
Bashkov
G B
GB
Sergeev
I Iu
IIu
Medvedeva
N A
NA
Makarov
V A
VA
D000818:Animals; D002415:Cats; D005342:Fibrinolysis / Q000187:drug effects / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006614:Hindlimb / Q000098:blood supply; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000097:blood / Q000187:drug effects / Q000378:metabolism*
D011950:Receptors, Cholinergic; D010959:Tissue Plasminogen Activator
Rol' simpaticheskogo kholinergicheskogo puti v neĭrogennom kontrole vydeleniia v krov' aktivatora plazminogena tkanevogo tipa.