Cell shrinkage follows, rather than mediates, the short-term effects of glucagon on carbohydrate metabolism.
The initial effects of glucagon on glycogen breakdown in isolated hepatocytes were found to be independent of cell volume and, when it occurred, cell shrinkage followed rather than mediated the glycogenolytic effect of glucagon. Similar conclusions could be drawn for the effect of glucagon on glycolysis/gluconeogenesis and for the antagonistic effect of insulin on glucagon action.
Gaussin
V
V
Hormone and Metabolic Research Unit, University of Louvain Medical School, Brussels, Belgium.
Baquet
A
A
Hue
L
L
D000818:Animals; D048429:Cell Size / Q000187:drug effects; D000242:Cyclic AMP / Q000378:metabolism; D005934:Glucagon / Q000494:pharmacology*; D005943:Gluconeogenesis / Q000187:drug effects; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D006005:Phosphorylases / Q000378:metabolism; D011770:Pyruvate Kinase / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014882:Water-Electrolyte Balance / Q000187:drug effects
D007328:Insulin; D008112:Liver Glycogen; D005934:Glucagon; D000242:Cyclic AMP; D006005:Phosphorylases; D011770:Pyruvate Kinase