title: A new look in the management of unresectable primary hepatocellular carcinoma.
abstract: From January 1992 to October 1992, nine patients with unresectable primary hepatocellular carcinoma were treated either by liver resection combined with transarterial on-target chemotherapy (n = 4) or by transarterial on-target chemotherapy alone (n = 5). All nine patients were seen with diffuse spread of their disease and were considered as refractory to surgical treatment. The patients who had liver resection combined with alcohol transtumoral injection of the residual tumor in the liver remnant and transarterial lipiodol on-target chemotherapy, responded well and were seen postoperatively with a significant decrease in size of their residual tumor, which was found histologically to have advanced necrotic changes. Similarly, the remaining patients, who had only alcohol injection and frequent administration of on-target chemotherapy, were seen with necrosis of their tumor and with decrease in its size. The fetoprotein serum levels were decreased in all patients. None of the patients showed systemic effects from the use of chemotherapy, nor did they demonstrate any hepatotoxic side effects.
authors.affiliation: Dept. of Hepatobiliary Pancreatic Surgery, Hellenic Anticancer Institute, St. Savas Hospital, Athens, Greece.
authors.forename: N J
authors.initials: NJ
authors.lastname: Lygidakis
authors.forename: G
authors.initials: G
authors.lastname: Savanis
authors.forename: A E
authors.initials: AE
authors.lastname: Konstantinidou
authors.forename: S
authors.initials: S
authors.lastname: Markidou
authors.forename: E
authors.initials: E
authors.lastname: Touloupakis
authors.forename: T
authors.initials: T
authors.lastname: Pavlis
authors.forename: M
authors.initials: M
authors.lastname: Saleh
authors.forename: E
authors.initials: E
authors.lastname: Eftichidou
authors.forename: K
authors.initials: K
authors.lastname: Stringaris
authors.forename: A
authors.initials: A
authors.lastname: Tavernaraki
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D003974:Diatrizoate Meglumine / Q000008:administration & dosage; D000431:Ethanol / Q000008:administration & dosage; D006498:Hepatectomy; D006801:Humans; D007261:Infusions, Intra-Arterial; D015552:Injections, Intralesional; D007459:Iodized Oil / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D008297:Male; D009336:Necrosis; D011379:Prognosis
chemical_list: D000970:Antineoplastic Agents; D000431:Ethanol; D003974:Diatrizoate Meglumine; D007459:Iodized Oil