[Anoxia-induced changes in cAMP contents in the cat cerebral cortex].
Effect of the cessation of oxygen supply on cAMP content and neuronal spike activity (NSA) in the cortex brain was studied. The interruption of oxygen supply during in first decades of seconds evoked changes in the pattern of NSA, followed with the decrease of cAMP content (to 56 +/- 10%). Then the phase of neuronal hyperactivity and increase of cAMP level (to 198 +/- 26%) took place. The content of cAMP approximated the basal one in 2.5 min anoxia. Anoxia during 5 min resulted in direct opposite shifts of cAMP content in two groups of cats (an increase up to 223 +/- 11%, and decrease up to 75 +/- 8%, respectively, which correlated with individual features of NSA recovery in postanoxic period and values of cAMP basal level in the cortex of different animals. Upon 30 min reoxygenation after 2.5 min anoxia a decline of the content of cAMP (to 63 +/- 12%) accompanied enhance of NSA. This period of reoxygenation after 5 min anoxia demonstrated two types of reactions, observed in different groups of cats: the first type--NSA tended to normalization with the level of cAMP 44 +/- 8% below basal level, and the second type--insufficient recovery of NSA attended by value of cAMP 90 +/- 13% above basal level.
Bolekhan
E A
EA
D000818:Animals; D002415:Cats; D002540:Cerebral Cortex / Q000378:metabolism / Q000502:physiology*; D000242:Cyclic AMP / Q000378:metabolism / Q000502:physiology*; D000860:Hypoxia / Q000378:metabolism / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D009474:Neurons / Q000502:physiology; D013997:Time Factors
D000242:Cyclic AMP
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