[Recurrence of virus B hepatitis after liver transplantation].
Thirty-three HBs antigen positive patients without signs of viral replication underwent orthotopic liver transplantation and received long term passive immunoprophylaxis with anti-HBs immunoglobulins at high doses perioperatively and then at a dose of 10,000 IU every month. All patients became negative during the first 6 months following surgery. At 34 months the survival rate was 67 percent and the actuarial recurrence rate of serum HBs antigen was 7.1 percent. Reappearance of HBs antigen was associated with evidence of HBV replication and histological alterations of the graft. In our experience, long term passive immunoprophylaxis reduces HBV reinfection of the grafted liver.
Gugenheim
J
J
Service de Chirurgie Digestive et Centre de Transplantation Hépatique, Université de Nice-Sophia Antipolis, Hôpital Saint-Roch.
Crafa
F
F
Fabiani
P
P
Militerno
G
G
Goubaux
B
B
Saint-Paul
M C
MC
Ouzan
D
D
Mouiel
J
J
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006509:Hepatitis B / Q000150:complications / Q000276:immunology / Q000401:mortality / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000008:administration & dosage*; D006511:Hepatitis B Antigens / Q000032:analysis; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008103:Liver Cirrhosis / Q000209:etiology / Q000601:surgery*; D008113:Liver Neoplasms / Q000150:complications / Q000601:surgery; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012008:Recurrence
D006510:Hepatitis B Antibodies; D006511:Hepatitis B Antigens; D016756:Immunoglobulins, Intravenous
Récidive du virus de l'hépatite B après transplantation hépatique.