Ubiquitin expression in globose tangles in the locus coeruleus in brains of patients with Alzheimer's and Parkinson's diseases.
The locus coeruleus belongs to brain areas exhibiting remarkable neuronal loss already during physiological aging and very early neurofibrillary tangles. We performed a semiquantitative, immunocytochemical study focused on the expression of ubiquitin in neurofibrillary tangles in the locus coeruleus as compared with the central superior nucleus. The locus coeruleus exhibited later ubiquitin expression in the neurofibrillary tangles, a lower percentage of ubiquitinated tangles and more frequently granular cytoplasmic staining with Tau-1 than the central superior nucleus. These results suggesting different, probably delayed, processing of Tau protein in the locus coeruleus might contribute additionally to cell injury in this area.
Kida
E
E
Department of Neuropathology, Medical Research Centre, Polish Academy of Sciences, Warszawa.
Barcikowska
M
M
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D016631:Lewy Bodies / Q000473:pathology; D008125:Locus Coeruleus / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D016874:Neurofibrillary Tangles / Q000378:metabolism*; D010300:Parkinson Disease / Q000378:metabolism* / Q000473:pathology; D011499:Protein Processing, Post-Translational; D014452:Ubiquitins / Q000096:biosynthesis*; D016875:tau Proteins / Q000378:metabolism
D009419:Nerve Tissue Proteins; D014452:Ubiquitins; D016875:tau Proteins