Hepatic angiomyolipomas with a deceptive trabecular pattern and HMB-45 reactivity.
We report two cases of giant hepatic angiomyolipoma with a prominent component of epithelioid smooth muscle cells exhibiting a distinctive trabecular arrangement. These cells possessed peripherally vacuolated and centrally condensed hyaline cytoplasm. The nuclei were eccentrically placed in the cytoplasm. Immunohistochemically, they expressed HMB-45 intensely in the central condensed cytoplasm and actin in a perimembranous fashion. Staining for desmin, myoglobin and vimentin was negative. HMB-45 may prove to be a sensitive marker for angiomyolipoma with epithelioid cells. Hepatocellular carcinoma and other hepatic tumours with polygonal clear cells can be readily distinguished by these means.
Tsui
W M
WM
Institute of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong.
Yuen
A K
AK
Ma
K F
KF
Tse
C C
CC
D000328:Adult; D000911:Antibodies, Monoclonal; D015415:Biomarkers; D006528:Carcinoma, Hepatocellular / Q000737:chemistry / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006391:Hemangioma / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008067:Lipoma / Q000737:chemistry / Q000473:pathology*; D008113:Liver Neoplasms / Q000737:chemistry / Q000473:pathology*; D008875:Middle Aged
D000911:Antibodies, Monoclonal; D015415:Biomarkers