The physiological role of estradiol 17-sulfate during pregnancy.
To clarify the physiological role of estradiol 17-sulfate (ES) during pregnancy, experiments were conducted and the following results were obtained: (1) serum or urinary ES levels rose as a function of gestational age; (2) placental microsomes showed fairly high 2- and 4-hydroxylase activity for ES; and (3) the catechol products, 2- and 4-hydroxy-ES, had a strong inhibitory effect upon the in vitro production of lipid peroxides. These results suggest that ES acts as a precursor to the catechol metabolites which maintain normal gestation. This is coincident with the negative correlation of serum levels in ES and lipid peroxides observed in late pregnancy.
Yoshizawa
I
I
Hokkaido Institute of Pharmaceutical Sciences, Japan.
Takanashi
K
K
Watanabe
K
K
Sato
T
T
Honjo
H
H
Tanaka
K
K
Sakuragi
N
N
Fujimoto
S
S
D002851:Chromatography, High Pressure Liquid; D004958:Estradiol / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000652:urine; D004966:Estrogens, Conjugated (USP) / Q000378:metabolism*; D005260:Female; D006801:Humans; D006900:Hydroxylation; D008054:Lipid Peroxides / Q000097:blood; D008861:Microsomes / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy / Q000502:physiology*; D013739:Testosterone / Q000378:metabolism
D004966:Estrogens, Conjugated (USP); D008054:Lipid Peroxides; C048615:estradiol 17-sulfate; D013739:Testosterone; D004958:Estradiol