title: Comparison of carbon monoxide and nitrogen induced effects on synaptic transmission in the rat hippocampal slice.
abstract: A comparison has been made of the effects of carbon monoxide (CO) or nitrogen (N2) exposure on synaptic transmission in the hippocampal slice. CA1 field potentials, evoked by Schaffer collateral stimulation, were unaffected by superfusion of slices with artificial cerebral spinal fluid (ACSF) equilibrated with either 15% CO or 15% N2 for 120 min. However, superfusion with hypoxic ACSF equilibrated with either 85% CO or 85% N2 caused a rapid depression of synaptic transmission. Reperfusion with control ACSF following 30 min hypoxia led to recovery of evoked responses and a slight hyperexcitability. In the hippocampal slice, synaptic transmission, as assessed by input/output curves, was not different during or following hypoxia induced by exposure to CO or N2. In the short term, CO is not toxic.
authors.affiliation: Department of Anaesthesia and Intensive Care, University of Adelaide, Australia.
authors.forename: D J
authors.initials: DJ
authors.lastname: Doolette
authors.forename: D I
authors.initials: DI
authors.lastname: Kerr
mesh_terms: D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D002248:Carbon Monoxide / Q000494:pharmacology*; D005071:Evoked Potentials / Q000187:drug effects; D006624:Hippocampus / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D009412:Nerve Fibers / Q000187:drug effects / Q000502:physiology; D009584:Nitrogen / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013569:Synapses / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D002248:Carbon Monoxide; D009584:Nitrogen