[The mechanism of the antiviral activity of an antiviral factor of a non-interferon nature].
Antiviral factor (AF) of protein nature has been isolated from chick embryo fibroblasts infected with Venezuelan equine encephalitis virus. The suppression of virus reproduction has been observed both in homologous and heterologous cell cultures when the preparation was introduced immediately after the adsorption of the virus after pretreatment of the cell monolayer. The study has demonstrated that the antiviral effect of AF is not linked with its IFN-alpha and TNF-alpha activity. Analysis of the results obtained in this study and earlier data contained in literature suggests that infected chick embryo fibroblasts release original cytokine of non-interferon nature with antiviral activity.
Gribkov
N V
NV
Votiakov
V I
VI
Goretskaia
I S
IS
Vorontsova
T V
TV
Kolesnikova
T S
TS
Moshchik
K V
KV
D000818:Animals; D002460:Cell Line; D002642:Chick Embryo; D016207:Cytokines / Q000302:isolation & purification / Q000494:pharmacology*; D004666:Encephalitis Virus, Venezuelan Equine / Q000187:drug effects / Q000502:physiology; D005347:Fibroblasts / Q000276:immunology / Q000382:microbiology; D006801:Humans; D007369:Interferon Inducers / Q000494:pharmacology; D016898:Interferon-alpha / Q000032:analysis; D007739:L Cells / Q000276:immunology / Q000382:microbiology; D051379:Mice; D008970:Molecular Weight; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects / Q000502:physiology; D014776:Virus Cultivation; D014779:Virus Replication / Q000187:drug effects
D016207:Cytokines; D007369:Interferon Inducers; D016898:Interferon-alpha; D014409:Tumor Necrosis Factor-alpha
O mekhanizme protivovirusnoĭ aktivnosti antivirusnogo faktora neinterferonovoĭ prirody.