CGRP stimulates the adhesion of leukocytes to vascular endothelial cells.
Calcitonin gene-related peptide (CGRP) stimulates the adhesiveness of human umbilical vein endothelial cells for U937 cells and human neutrophils in a dose- and time-dependent manner. The onset of CGRP-induced adhesives of HUVEC was rapid (30 min), independent of protein synthesis, and lasted over 24 h in the continuous presence of the peptide. The stimulatory effect of CGRP was completely blocked by the CGRP antagonist, CGRP(8-37). The present study provides evidence in support of the potential role of sensory nerve-derived neuropeptides in the modulation of leukocyte adhesion to vascular endothelial cells.
Sung
C P
CP
Department of Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406.
Arleth
A J
AJ
Aiyar
N
N
Bhatnagar
P K
PK
Lysko
P G
PG
Feuerstein
G
G
D015740:Calcitonin Gene-Related Peptide / Q000031:analogs & derivatives / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects*; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D010105:Oxygenases / Q000378:metabolism; D010972:Platelet Activating Factor / Q000378:metabolism; D013917:Thrombin / Q000494:pharmacology; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology; D014471:Umbilical Veins / Q000187:drug effects / Q000502:physiology
D010972:Platelet Activating Factor; D014409:Tumor Necrosis Factor-alpha; D000242:Cyclic AMP; D010105:Oxygenases; D013917:Thrombin; D015740:Calcitonin Gene-Related Peptide