title: Molecular cloning of the cDNA encoding a receptor tyrosine kinase-related molecule with a catalytic region homologous to c-met.
abstract: Receptor tyrosine kinases mediate a range of growth and differentiation processes in multiple biological systems. In this work, we report the identification of a novel tyrosine kinase-related molecule, nyk-r, and the molecular cloning of its complete cDNA. Its extra-cellular domain bears no apparent homology with other receptor families, but its intracellular kinase-related region has considerable similarity with members of the insulin-receptor family such as c-met and trk B. Also, the nyk-r gene is expressed in a wide range of tissues and cell lines.
authors.affiliation: Genetics Institute, Inc., Cambridge, Massachusetts.
authors.forename: S R
authors.initials: SR
authors.lastname: Paul
authors.forename: D
authors.initials: D
authors.lastname: Merberg
authors.forename: H
authors.initials: H
authors.lastname: Finnerty
authors.forename: G E
authors.initials: GE
authors.lastname: Morris
authors.forename: J C
authors.initials: JC
authors.lastname: Morris
authors.forename: S S
authors.initials: SS
authors.lastname: Jones
authors.forename: R
authors.initials: R
authors.lastname: Kriz
authors.forename: K J
authors.initials: KJ
authors.lastname: Turner
authors.forename: C R
authors.initials: CR
authors.lastname: Wood
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D003001:Cloning, Molecular; D051379:Mice; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides / Q000235:genetics; D016133:Polymerase Chain Reaction; D011505:Protein-Tyrosine Kinases / Q000737:chemistry / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000235:genetics*; D019859:Proto-Oncogene Proteins c-met; D020794:Receptor Protein-Tyrosine Kinases; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D014407:Tumor Cells, Cultured; D000076202:c-Mer Tyrosine Kinase
chemical_list: D009838:Oligodeoxyribonucleotides; D011518:Proto-Oncogene Proteins; D011956:Receptors, Cell Surface; C490767:Mertk protein, mouse; D011505:Protein-Tyrosine Kinases; D019859:Proto-Oncogene Proteins c-met; D020794:Receptor Protein-Tyrosine Kinases; D000076202:c-Mer Tyrosine Kinase