Transganglionic effects of Nocodazole, a new synthetic microtubule inhibitor, upon the histochemical structure of the spinal upper dorsal horn.
Perineural application of Nocodazole (R 17934 of Janssen Pharmaceutica), a new synthetic microtubule inhibitor, induces transganglionic degenerative atrophy of central terminals in the spinal cord of the inflicted primary sensory neurons. This drug offers new possibilities for clinical trials aiming to relieve chronic pain by subcutaneous injection of a microtubule inhibitor.
Porubcsanszki
Z
Z
Department of Anatomy, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Csillik
B
B
D000818:Animals; D005260:Female; D005724:Ganglia / Q000187:drug effects / Q000502:physiology*; D006651:Histocytochemistry; D008297:Male; D008870:Microtubules / Q000187:drug effects*; D009410:Nerve Degeneration / Q000187:drug effects; D009414:Nerve Growth Factors / Q000096:biosynthesis; D015739:Nocodazole / Q000494:pharmacology*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D051381:Rats; D012584:Sciatic Nerve / Q000166:cytology / Q000187:drug effects; D013116:Spinal Cord / Q000166:cytology* / Q000187:drug effects
D009414:Nerve Growth Factors; C022734:thiamine monophosphatase; D010744:Phosphoric Monoester Hydrolases; D015739:Nocodazole