title: Preliminary studies on congenital hypothyroidism in a family of Abyssinian cats.
abstract: Congenital hypothyroidism was diagnosed in related Abyssinian cats. The disease appeared to be inherited as an autosomal recessive trait with affected homozygotes showing signs of reduced growth rate, shorter stature with kitten-like features, constipation and goitre. Hypothyroidism was confirmed by demonstrating low basal serum thyroxine levels which failed to increase after intravenous administration of thyroid stimulating hormone or thyrotropic releasing hormone. The radioiodide uptake of the thyroid glands was normal but a high proportion of the accumulated radioiodide was discharged after the administration of sodium perchlorate. It is concluded that the affected cats had a primary dyshormonogenesis: an organification (peroxidase) defect.
authors.affiliation: Department of Veterinary Clinical Sciences, Massey University, Palmerston North, New Zealand.
authors.forename: B R
authors.initials: BR
authors.lastname: Jones
authors.forename: T J
authors.initials: TJ
authors.lastname: Gruffydd-Jones
authors.forename: A H
authors.initials: AH
authors.lastname: Sparkes
authors.forename: V M
authors.initials: VM
authors.lastname: Lucke
mesh_terms: D000818:Animals; D001947:Breeding; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000150:complications / Q000662:veterinary; D002371:Cat Diseases / Q000151:congenital* / Q000235:genetics; D002415:Cats; D002784:Cholesterol / Q000097:blood; D003409:Congenital Hypothyroidism; D005260:Female; D006720:Homozygote; D007037:Hypothyroidism / Q000235:genetics / Q000662:veterinary*; D007178:Inbreeding; D008297:Male; D010190:Pancreatic Neoplasms / Q000150:complications / Q000662:veterinary; D013047:Specific Pathogen-Free Organisms; D013960:Thyroid Function Tests / Q000662:veterinary; D013961:Thyroid Gland / Q000473:pathology; D013974:Thyroxine / Q000097:blood
chemical_list: D002784:Cholesterol; D013974:Thyroxine