title: 1 alpha-Hydroxycholecalciferol adsorption to peritoneal dialysis bags: influence of time, glucose concentration, temperature, and albumin.
abstract: The present study examines the adsorptive phenomenon of 1 alpha-hydroxycholecalciferol (1 alpha-OHD3) to peritoneal dialysis bags. One minute after injection of 1 alpha-OHD3 into the dialysis bags, a significant adsorption to the bags was observed in experiments where albumin was not added. A higher temperature (37 degrees versus 23 degrees C) in bags containing 13.6 mg glucose/ml resulted in less adsorption (P < 0.05). Adding albumin to bags at 37 degrees C with a glucose concentration of 13.6 mg/ml, reduced the adsorptive phenomenon significantly (P < 0.01). Bags tested at 37 degrees C with a glucose concentration of 38.6 mg/ml resulted in a significantly higher 1 alpha-OHD3 adsorption than bags containing 13.6 mg glucose/ml (P < 0.01). It is concluded that adsorption of 1 alpha-OHD3 to dialysis bags is affected by time, albumin, temperature and glucose concentrations. Substantial amounts of 1 alpha-OHD3 is retained by the peritoneal dialysis system when albumin is not added.
authors.affiliation: Department of Nephrology, Herlev County Hospital, Denmark.
authors.forename: P
authors.initials: P
authors.lastname: Joffe
authors.forename: S D
authors.initials: SD
authors.lastname: Ladefoged
authors.forename: C
authors.initials: C
authors.lastname: Cintin
authors.forename: H
authors.initials: H
authors.lastname: Lehmann
mesh_terms: D000327:Adsorption; D000418:Albumins / Q000008:administration & dosage; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000517:prevention & control; D015314:Dialysis Solutions; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D006887:Hydroxycholecalciferols / Q000493:pharmacokinetics*; D066298:In Vitro Techniques; D010530:Peritoneal Dialysis / Q000295:instrumentation*; D013696:Temperature; D013997:Time Factors
chemical_list: D000418:Albumins; D015314:Dialysis Solutions; D006887:Hydroxycholecalciferols; D005947:Glucose; C008088:alfacalcidol