[Synthesis of nucleoside 5'-fluoroalkylphosphonate--compounds with potential antiviral properties].
Several 5'-fluoroalkylphosphonates of 3'-azido-3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine were synthesized as potential antiviral compounds. Fluoromethyl, difluoromethyl, fluorochloromethyl and vinyl phosphonates were used as phosphonylating components, with dicyclohexylcarbodiimide or triisopropylbenzenesulphonyl chloride as condensing reagents.
Diatkina
N B
NB
Ias'ko
M V
MV
Arzumanov
A A
AA
Kraevskiĭ
A A
AA
Semchenko
F M
FM
Eremin
O G
OG
Martynov
B I
BI
D000998:Antiviral Agents / Q000138:chemical synthesis*; D015224:Dideoxynucleosides / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D009943:Organophosphorus Compounds / Q000138:chemical synthesis*; D018119:Stavudine; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000138:chemical synthesis
D000998:Antiviral Agents; D015224:Dideoxynucleosides; D009943:Organophosphorus Compounds; D015215:Zidovudine; D018119:Stavudine
Sintez 5'-ftoralkilfosfonatov nukleosideov--soedineniĭ s potentsial'nymi protivovirusnymi svoĭstvami.