[Role of Langerhans' cells against cervical human papilloma virus infection and development of cervical carcinoma].
Human papilloma virus (HPV) in the development of cervicitis and cervical carcinoma, and the role of Langerhans' cells (LC) against cervical HPV infection and development of cervical carcinoma were studied by immunohistochemistry and by DNA molecular hybridization techniques for the HPV type 6, 11, 16 and 18 DNA sequences. The total results were analysed and correlated. It was found that the positive rate of HPV type 6 and 11 in cervicitis was significantly higher than that in cervical carcinoma (P less than 0.01), and the positive rate of HPV type 16 and 18 was higher than that in cervicitis, but only the difference of HPV type 16 positive rate reaches significance level (P less than 0.01). The results also showed that the mean density of S100 + LC in cervical carcinoma specimens was significantly higher than that in cervicitis specimens (P less than 0.01). The results indicate that HPV type 6 and 11 are closely related with cervicitis, and HPV type 16 and 18 are closely related with the development of cervical carcinoma. LC plays an important role in attacking HPV infection of the cervix and the development of cervical carcinoma. The results also suggest that S100 + LC and OKT6 + LC are different subtypes of LC, and S100 + LC is an activated-subtype which plays a major role of immunosurveillance function.
Meng
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X
Institute of Basic Medical Sciences, Shandong Academy of Medical Sciences, Jinan.
D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000382:microbiology*; D002584:Cervix Uteri / Q000382:microbiology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D007801:Langerhans Cells / Q000502:physiology*; D027383:Papillomaviridae / Q000302:isolation & purification*; D014412:Tumor Virus Infections / Q000276:immunology*; D002583:Uterine Cervical Neoplasms / Q000276:immunology / Q000382:microbiology*; D002575:Uterine Cervicitis / Q000382:microbiology
D004279:DNA, Viral