title: Increased responses to adenosine and 2-chloroadenosine of cyclic AMP-generating systems in the primary cortical region of cobalt-induced epilepsy in the rat.
abstract: The epileptic activity was induced by an injection of cobalt chloride solution into the unilateral sensorimotor cortex of rats. Cyclic AMP accumulations elicited by adenosine and 2-chloroadenosine were investigated in slices from different regions of the epileptic cortex. The cyclic AMP accumulation was increased in the primary cortical region of cobalt-induced epilepsy. The greatest increase in cyclic AMP accumulation was detected between 2 and 3 weeks after treatment by cobalt, in conjunction with the electrographic and behavioral findings. The results suggest the functional significance of cortical cyclic AMP-generating systems in cobalt-induced epilepsy.
authors.affiliation: Department of Physiology, Okayama University Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hattori
authors.forename: A
authors.initials: A
authors.lastname: Moriwaki
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Y F
authors.initials: YF
authors.lastname: Lu
authors.forename: Y
authors.initials: Y
authors.lastname: Hori
mesh_terms: D015762:2-Chloroadenosine / Q000494:pharmacology; D000200:Action Potentials; D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology; D003035:Cobalt; D000242:Cyclic AMP / Q000096:biosynthesis*; D004827:Epilepsy / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D015762:2-Chloroadenosine; D003035:Cobalt; D000242:Cyclic AMP; D000241:Adenosine