The rat LPH gene 5' region: comparative structure with the human gene.
We have determined the sequence of a 2784 bp rat genomic fragment originating from the 5' region of the gene coding for intestinal lactase-phlorizin hydrolase. The fragment overlaps the gene exon 1, part of the intron 1 and the 5'-upstream segment including a TATA-like box. Over 155 bp, the upstream segment shows 72% similarity with the corresponding sequence in human. Far upstream, the rat sequence exhibits a Calcium Responsive Element and putative binding sites for AP2, C/EBP, and CTF/NF. The intron contains a T-rich sequence that may cause DNA helix distortion.
Boukamel
R
R
Institute National de la Santé et de la Recherche Médicale Unité 61, Strasbourg, France.
Freund
J N
JN
D000818:Animals; D001483:Base Sequence; D004247:DNA; D006801:Humans; D010694:Lactase-Phlorizin Hydrolase / Q000235:genetics*; D008969:Molecular Sequence Data; D051381:Rats; D015183:Restriction Mapping; D017385:Sequence Homology
D004247:DNA; D010694:Lactase-Phlorizin Hydrolase