Retinoic acid decreases retinoic acid and triiodothyronine nuclear receptor expression in the liver of hyperthyroidic rats.
Retinoic acid (RA) and triiodothyronine (T3) exert many of their actions by binding to specific nuclear receptors (respectively, RA receptor (RAR) and T3) receptor (TR) belonging to a 'superfamily' of receptors. Some heterologous regulation of these receptors has been shown, and in particular regulation of the maximum binding capacity of TR by either retinol or RA. Now, using hyperthyroidic rats as a model, the effect of RA on binding capacity and on the mRNA levels of TR and RAR was investigated. The results show that the benefit of vitamin A treatment for the hyperthyroidic state, which has been described for a long time, could be the result of a down-heteroregulation of TR by RA, the active metabolite of retinol.
Higueret
P
P
Laboratoire de Nutrition, ISTAB, Université Bordeaux I, Talence, France.
Pallet
V
V
Coustaut
M
M
Audouin
I
I
Begueret
J
J
Garcin
H
H
D000818:Animals; D001345:Autoradiography; D001483:Base Sequence; D002352:Carrier Proteins / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D002850:Chromatography, Gel; D004247:DNA; D006980:Hyperthyroidism / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D018168:Receptors, Retinoic Acid; D011988:Receptors, Thyroid Hormone / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D014212:Tretinoin / Q000494:pharmacology*
D002352:Carrier Proteins; D012333:RNA, Messenger; D018168:Receptors, Retinoic Acid; D011988:Receptors, Thyroid Hormone; D014212:Tretinoin; D004247:DNA