Effects of amphetamine on the development of MTV-induced mammary tumors in female mice.
Female C3H/He mice carrying the mammary tumor virus (MTV) were monitored for mammary tumor incidence and latent periods while submitted to a daily subcutaneous injection with amphetamine (0,4 mg/kg/day). Results show that amphetamine caused an increase in incidence and a decrease in latency of tumors compared with placebo. There was also appreciated a correlation with the lethality of mice.
Freire-Garabal
M
M
Department of Pharmacology, School of Medicine, University of Santiago, Spain.
Núñez
M J
MJ
Balboa
J L
JL
Suárez
J A
JA
Gallego
A
A
Belmonte
A
A
D000661:Amphetamine / Q000008:administration & dosage / Q000009:adverse effects*; D000818:Animals; D004334:Drug Administration Schedule; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced* / Q000382:microbiology / Q000517:prevention & control; D008324:Mammary Tumor Virus, Mouse / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008809:Mice, Inbred C3H; D014779:Virus Replication / Q000187:drug effects
D000661:Amphetamine