title: Alpha-adrenergic bronchoprovocation in neonates with bronchopulmonary dysplasia.
abstract: Ophthalmic administration of phenylephrine caused decreased pulmonary compliance, tidal volume, and peak airflow values in infants with bronchopulmonary dysplasia but not in control infants. The alpha-adrenergic effects of phenylephrine may aggravate the bronchospastic component of bronchopulmonary dysplasia.
authors.affiliation: Section on Newborn Pediatrics, Pennsylvania Hospital.
authors.forename: S J
authors.initials: SJ
authors.lastname: Mirmanesh
authors.forename: S
authors.initials: S
authors.lastname: Abbasi
authors.forename: V K
authors.initials: VK
authors.lastname: Bhutani
mesh_terms: D016535:Bronchial Hyperreactivity; D001985:Bronchial Provocation Tests; D001997:Bronchopulmonary Dysplasia / Q000503:physiopathology*; D016022:Case-Control Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009883:Ophthalmic Solutions; D010656:Phenylephrine / Q000008:administration & dosage / Q000494:pharmacology*; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D015656:Respiratory Mechanics / Q000187:drug effects*
chemical_list: D009883:Ophthalmic Solutions; D011942:Receptors, Adrenergic, alpha; D010656:Phenylephrine