title: Evolution of collagen arthritis in mice is arrested by treatment with anti-tumour necrosis factor (TNF) antibody or a recombinant soluble TNF receptor.
abstract: Immunization of DBA/1 mice with type II collagen within complete Freund's adjuvant leads to arthritis, lasting more than 3 months. Injection of anti-tumour necrosis factor (TNF) IgG, 2 and 3 weeks after immunization prevented the development of arthritis in the following months. This treatment had no effect when started 2 months after induction of the disease. A soluble form of the human recombinant TNF receptor type-beta (rsTNFR-beta), continuously infused at a rate of 20 micrograms/day during the second and third week after immunization, also had a long-term protective effect. Anti-TNF antibody had no effect upon the production of anti-type II collagen antibodies. These results indicate that TNF is critically involved in an early phase of this arthritis.
authors.affiliation: Department of Pathology, University of Geneva, Switzerland.
authors.forename: P F
authors.initials: PF
authors.lastname: Piguet
authors.forename: G E
authors.initials: GE
authors.lastname: Grau
authors.forename: C
authors.initials: C
authors.lastname: Vesin
authors.forename: H
authors.initials: H
authors.lastname: Loetscher
authors.forename: R
authors.initials: R
authors.lastname: Gentz
authors.forename: W
authors.initials: W
authors.lastname: Lesslauer
mesh_terms: D000818:Animals; D001168:Arthritis / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control; D001323:Autoantibodies / Q000096:biosynthesis; D003094:Collagen / Q000276:immunology*; D005528:Foot / Q000473:pathology; D007074:Immunoglobulin G / Q000276:immunology; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D012333:RNA, Messenger / Q000032:analysis; D011956:Receptors, Cell Surface / Q000276:immunology; D018124:Receptors, Tumor Necrosis Factor; D011994:Recombinant Proteins / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D018124:Receptors, Tumor Necrosis Factor; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D003094:Collagen