The evolution of RNA editing in kinetoplastid protozoa.
RNA editing alters messenger RNA transcripts by the addition and deletion of uridine residues. This remarkable process corrects frameshift mutations and replaces AUG initiation codons in most trypanosomatid mitochondrial RNA transcripts. Sometimes, however, RNA editing results in open reading frames whose sequences differ by greater than 50% from the original RNA sequences. In this paper, we will explore two models for the evolution of RNA editing in kinetoplastid protoza.
Landweber
L F
LF
Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138.
D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D003576:Electron Transport Complex IV / Q000235:genetics; D016830:Kinetoplastida / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D008969:Molecular Sequence Data; D017393:RNA Editing; D016053:RNA, Protozoan / Q000235:genetics / Q000378:metabolism; D012689:Sequence Homology, Nucleic Acid
D016053:RNA, Protozoan; D003576:Electron Transport Complex IV