title: Protective effect of radio-detoxified endotoxin (Tolerin) on the ultrastructure of pancreas in experimental endotoxin shock of rats.
abstract: The ultrastructural changes of pancreas exocrine cells were studied after the intravenous administration of endotoxin (LPS) or radio-detoxified endotoxin (150 kGy 60Co-gamma irradiated: RD-LPS or Tolerin). The LPS (1 mg/rat) induces an autolytic destruction in the membranes of the mitochondria of the pancreas exocrine cells. The RD-LPS given in similar dose does not produce any autolytic change. However, a small dose (100/micrograms/rat) of RD-LPS (Tolerin) as a pretreatment can protect the autolytic destruction of the mitochondria induced by LPS. This may be attributed to the membrane stabilizing effect of RD-LPS.
authors.affiliation: Department of General and Thoracic Surgery, Semmelweis Teaching Hospital, Miskolc, Hungary.
authors.forename: S
authors.initials: S
authors.lastname: Bende
authors.forename: L
authors.initials: L
authors.lastname: Bertók
authors.forename: S
authors.initials: S
authors.lastname: Bende
mesh_terms: D000818:Animals; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli; D005260:Female; D008070:Lipopolysaccharides; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000473:pathology; D010179:Pancreas / Q000648:ultrastructure*; D051381:Rats; D012772:Shock, Septic / Q000473:pathology*
chemical_list: D004731:Endotoxins; D008070:Lipopolysaccharides; C010797:tolerin