[Sensitivity test to chemotherapeutic agents and cytotoxicic test against immuno-effecter cells of established malignant fibrous histiocytoma cell line].
A cell line was established from a patient with malignant fibrous histiocytoma, which had originated in the maxillary sinus. Using this cell line, sensitivity to chemotherapeutic agents and cytotoxicity against various immunoeffecter cells were tested.


RESULTS
This MFH cell line was sensitive in some degree to adriamycin, 5-fluorouracil, cisplatin, peplomycin, and methotrexate at high doses, but insensitive to mitomycin-C, vincristine and cyclophosphamide. Furthermore, this cell line showed no sensitivity to cytolytic cytokines, such as tumor necrosis factor-alpha and interferon-gamma. Lymphokine activated killer (LAK) cells and lymphokine activated tumor infiltrating lymphocytes (LA-TIL), induced by culture of peripheral blood lymphocytes and TIL respectively with rIL-2 showed high NK and LK activities and remarkable anti-autologous tumor ability.
Tsukuda
M
M
Department of Head and Neck Surgery, Kanagawa Cancer Center, Yokohama.
Kubota
A
A
Arai
Y
Y
Kaneko
M
M
Furukawa
S
S
Sawaki
S
S
D000970:Antineoplastic Agents / Q000494:pharmacology*; D003601:Cytotoxicity Tests, Immunologic; D004354:Drug Screening Assays, Antitumor; D018219:Histiocytoma, Benign Fibrous / Q000276:immunology / Q000473:pathology*; D006801:Humans; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology*; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology*; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000276:immunology / Q000473:pathology; D008875:Middle Aged; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000473:pathology
D000970:Antineoplastic Agents