Naloxone-sensitive potentiation at granule cell synapses in the ventral dentate gyrus and stress ulcers.
Continuous perfusion of the granule cells in the ventral dentate gyrus with naloxone blocked the long-term potentiation (LTP) induced by high-frequency electrical stimulation of the posterolateral amygdala in freely-moving rats. This treatment also aggravated the stomach ulceration produced by cold restraint. LTP, on the other hand, attenuated the gastric stress pathology. It was suggested that a naloxone-sensitive granule cell gate modulates the impact of environmental stressors.
Henke
P G
PG
Neuroscience Laboratory, St. Francis Xavier University, Antigonish, Nova Scotia, Canada.
D000818:Animals; D001143:Arousal / Q000187:drug effects* / Q000502:physiology; D004744:Enkephalin, Methionine / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000187:drug effects* / Q000502:physiology; D013276:Stomach Ulcer / Q000503:physiopathology*; D013315:Stress, Psychological / Q000503:physiopathology*; D013569:Synapses / Q000187:drug effects* / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology
D011957:Receptors, Opioid; D009270:Naloxone; D004744:Enkephalin, Methionine