[Successful preparation of mitoxantrone emulsion containing non-ionic contrast medium].
Mitoxantrone, a new anti-cancer agent, was successfully prepared for Lipiodol emulsion. The mixture of Mitoxantrone and non-ionic contrast medium, Omnipaque 300, was combined with Lipiodol at the ratio of 1:2. When the ratio of Mitoxantrone and Lipiodol was 1:4, microscopic study revealed stabilized water in oil emulsion, which could release the anti-cancer agent slowly. We applied it for a case of hepatocellular carcinoma with good result. Intra-arterial infusion of this emulsion might be considered effective for treatment of hepatocellular carcinoma.
Ichikawa
W
W
Second Dept. of Surgery, Tokyo Medical and Dental University, School of Medicine.
Nihei
Z
Z
Sawai
S
S
Yamashita
T
T
Uetake
H
H
Kawachi
Y
Y
Hirayama
R
R
Mishima
Y
Y
Tamaru
H
H
D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000473:pathology; D003692:Delayed-Action Preparations; D004359:Drug Therapy, Combination; D004655:Emulsions; D006801:Humans; D007459:Iodized Oil / Q000008:administration & dosage*; D007472:Iohexol / Q000008:administration & dosage*; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008942:Mitoxantrone / Q000008:administration & dosage*
D003692:Delayed-Action Preparations; D004655:Emulsions; D007472:Iohexol; D007459:Iodized Oil; D008942:Mitoxantrone