Comparative study of Ki-67 immunostaining and nuclear DNA content in histiofibrous tumors.
A comparative assessment was made of dermatofibroma, dermatofibrosarcoma protuberans, and malignant fibrous histiocytoma. The study was comprised of an immunohistochemical investigation using the Ki-67 monoclonal antibody and a quantitative analysis of cell nuclear DNA using flow cytometry. It was found that the index of Ki-67 monoclonal antibody labeling, the histogram pattern, and DNA index correlated with clinical malignancy, suggesting the usefulness of these indices for differential diagnosis and evaluation of prognosis.
Ooe
M
M
Department of Dermatology, Tokyo Women's Medical College, Japan.
Nogita
T
T
Kawashima
M
M
D000328:Adult; D004273:DNA, Neoplasm / Q000032:analysis*; D003937:Diagnosis, Differential; D005260:Female; D005350:Fibroma / Q000175:diagnosis*; D005354:Fibrosarcoma / Q000175:diagnosis* / Q000235:genetics; D018219:Histiocytoma, Benign Fibrous / Q000175:diagnosis*; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000235:genetics
D004273:DNA, Neoplasm; D019394:Ki-67 Antigen; D009687:Nuclear Proteins