[The effects of early stage load-bearing on bone ingrowth of porous coated implant in rabbits].
To understand the effects of load-bearing on cementless fixation of porous coated implant, we inserted Co-Cr-Mo alloy implants into the distal femur of rabbits. Specimens were studied by means of histology, anti-collagen type I and III immunohistochemical staining, colloidal gold labeled immunoelectron microscopy, and computerized graphic analysis. The results revealed that stimulations of load-bearing benefited bone ingrowth, but the newly formed bone in the pores was absorbed and replaced by fibrous tissues after 12 weeks without stimulations of load-bearing. The fibrous tissues in the pores of the implant were primarily type III collagen after one week and type I collagen after two weeks. After 6 weeks, the residual tissue between ingrowth bone and metal bound antibodies was type I collagen. Fibroblasts participated in and possessed the action of osteogenesis.
Sun
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Department of Orthopeadics, General Hospital, PLA, Beijing.
D000818:Animals; D001861:Bone Regeneration; D002858:Chromium Alloys; D003094:Collagen / Q000378:metabolism / Q000648:ultrastructure; D005260:Female; D007595:Joint Prosthesis; D007596:Joints / Q000503:physiopathology* / Q000601:surgery; D008297:Male; D016253:Microscopy, Immunoelectron; D011817:Rabbits; D013997:Time Factors; D016474:Weight-Bearing
D002858:Chromium Alloys; D003094:Collagen