title: Effect of chronic active immunization with antiarginine vasopressin on pituitary-adrenal function in sheep.
abstract: ACTH and cortisol diurnal variations and responses to two types of stress (insulin-induced hypoglycemia and isolation-restraint stress) and to an acute injection of CRF were determined in intact as well as in actively antiarginine vasopressin (AVP)-immunized rams. All immunized sheep developed antibodies to AVP, displayed diabetes insipidus, and looked healthy in spite of their lower gain weight. Basal secretion and diurnal variations of ACTH and cortisol were unaltered in the group of anti-AVP-immunized animals. In contrast, ACTH and cortisol responses to both types of stress and CRF injection were significantly reduced compared to those in controls. These results suggest that endogenous AVP plays a physiological role in the corticotropic response to stress. However, endogenous AVP does not appear to affect basal secretion and diurnal variations of ACTH and cortisol.
authors.affiliation: Laboratoire de Neuroendocrinologie Expérimentale, INSERM U. 297, Faculté de Médecine Nord, Marseille, France.
authors.forename: V
authors.initials: V
authors.lastname: Guillaume
authors.forename: B
authors.initials: B
authors.lastname: Conte-Devolx
authors.forename: E
authors.initials: E
authors.lastname: Magnan
authors.forename: F
authors.initials: F
authors.lastname: Boudouresque
authors.forename: M
authors.initials: M
authors.lastname: Grino
authors.forename: M
authors.initials: M
authors.lastname: Cataldi
authors.forename: L
authors.initials: L
authors.lastname: Muret
authors.forename: A
authors.initials: A
authors.lastname: Priou
authors.forename: J C
authors.initials: JC
authors.lastname: Figaroli
authors.forename: C
authors.initials: C
authors.lastname: Oliver
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism*; D000704:Analysis of Variance; D000818:Animals; D001127:Arginine Vasopressin / Q000276:immunology / Q000502:physiology*; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D002940:Circadian Rhythm; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D003919:Diabetes Insipidus / Q000503:physiopathology; D004327:Drinking Behavior; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism*; D007003:Hypoglycemia / Q000139:chemically induced / Q000503:physiopathology; D007116:Immunization, Passive; D007328:Insulin / Q000494:pharmacology; D008297:Male; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D012149:Restraint, Physical; D012756:Sheep; D013312:Stress, Physiological / Q000503:physiopathology; D013315:Stress, Psychological / Q000503:physiopathology
chemical_list: D001786:Blood Glucose; D007328:Insulin; D001127:Arginine Vasopressin; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone