A recurrent marker chromosome involving chromosome 1 in two mammary tumors of the dog.
An apparently identical marker chromosome resulting from a chromosome 1. translocation was found in the mammary carcinomas of two bitches. Although these karyotypic aberrations were the sole clonal aberrations detected, it was not possible to unambiguously identify the material translocated to the chromosome 1 in either animal. Our observations, however, represent the first report of a recurring marker chromosome in mammary tumors of the dog and suggest that these tumors may become an interesting model for human breast cancer.
Bartnitzke
S
S
Centre of Human Genetics and Genetic Counselling, University of Bremen, FRG.
Motzko
H
H
Caselitz
J
J
Kornberg
M
M
Bullerdiek
J
J
Schloot
W
W
D000818:Animals; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000235:genetics / Q000662:veterinary*; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000235:genetics; D004285:Dogs / Q000235:genetics; D005260:Female; D005819:Genetic Markers / Q000235:genetics*; D007621:Karyotyping; D015674:Mammary Neoplasms, Animal / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*
D005819:Genetic Markers