Effects of convulsant ligands of the GABA-benzodiazepine receptor complex in conflict and learning tasks in mice.
A systematic study of the effects of convulsants acting at the GABA-benzodiazepine receptor complex was undertaken in mice to estimate their potential anxiogenic effects and/or performance enhancing effects in learning and memory tasks. Anxiogenic effects were assessed in a conflict task where lever presses delivered both a food pellet and a mild electric foot shock. Effects on learning were assessed through analysis of habituation to a new environment. The convulsant agents pentylenetetrazol (PTZ) and picrotoxin (PX), both acting through the GABA-benzodiazepine receptor complex, and strychnine, a convulsant acting through the glycine transmission were used. Our data show that non convulsive doses of PTZ (25 mg/kg) and PX (0.85 mg/kg), but not of strychnine (0.8 mg/kg), are anxiogenic in the conflict model. At lower doses PTZ (10 mg/kg) and PX (0.3 mg/kg), but not strychnine (0.1 to 0.6 mg/kg), enhance performance in the habituation model. Our results contribute to the validation of the idea that small decreases in GABAergic transmission are accompanied by improvement of learning whereas medium decreases induce anxiogenic effects.
Venault
P
P
Département I, C.N.R.S., Gif-sur-Yvette.
Chapouthier
G
G
Prado de Carvalho
L
L
Rossier
J
J
D000818:Animals; D001070:Appetitive Behavior / Q000187:drug effects*; D001143:Arousal / Q000187:drug effects* / Q000502:physiology; D001245:Association Learning / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000502:physiology; D003214:Conditioning, Classical / Q000187:drug effects*; D003292:Convulsants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D011939:Mental Recall / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D009042:Motivation; D010433:Pentylenetetrazole / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000502:physiology; D013331:Strychnine / Q000494:pharmacology
D003292:Convulsants; D010433:Pentylenetetrazole; D010852:Picrotoxin; D011963:Receptors, GABA-A; D013331:Strychnine