Lack of effect of carbonyl cyanide m-chlorophenylhydrazone on KB-5246 accumulation by Staphylococcus aureus.
The accumulation of KB-5246 in a quinolone-susceptible strain of Staphylococcus aureus was about 70 times that of norfloxacin. Carbonyl cyanide m-chlorophenylhydrazone increased the accumulation of norfloxacin about eightfold, but it did not influence that of KB-5246. The low efflux of KB-5246 from S. aureus may contribute to its potent antibacterial activity.
Kotera
Y
Y
New Drug Research Laboratories, Kanebo, Ltd., Osaka, Japan.
Inoue
Y
Y
Ohashi
M
M
Ito
K
K
Inoue
M
M
D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D002258:Carbonyl Cyanide m-Chlorophenyl Hydrazone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D024841:Fluoroquinolones; D043803:Phenalenes; D015363:Quinolones / Q000493:pharmacokinetics*; D013211:Staphylococcus aureus / Q000737:chemistry / Q000187:drug effects*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D043803:Phenalenes; D015363:Quinolones; C062447:KB 5246; D002258:Carbonyl Cyanide m-Chlorophenyl Hydrazone