title: Comparative in-vitro activity of four peptide antibiotics against penicillin-resistant Streptococcus pneumoniae isolated from cerebrospinal fluid (CSF).
abstract: The in-vitro activity of four peptide antibiotics against 43 penicillin-resistant Streptococcus pneumoniae isolated from cerebrospinal fluid (CSF) was evaluated. The activity of SKF104662 was slightly greater to that of vancomycin, teicoplanin and daptomycin (MICs for 90% of the isolates tested 0.06, 0.25, 0.12 and 0.25 mg/L, respectively) and superior to the other 15 drugs tested. The serotype of these penicillin-resistant strains was also determined. The strains that belonged to the predominant serotype 9 were resistant only to penicillin. All six erythromycin- and clindamycin-resistant strains belonged to serotype 6 and three of them were also resistant to chloramphenicol and tetracycline (plus penicillin).
authors.affiliation: Servicio de Bacteriología, Centro Nacional de Microbiología, Madrid, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: Rodríguez-Tudela
authors.forename: F
authors.initials: F
authors.lastname: López de Felipe
authors.forename: J V
authors.initials: JV
authors.lastname: Martínez-Suárez
authors.forename: A
authors.initials: A
authors.lastname: Fenoll
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D002555:Cerebrospinal Fluid / Q000382:microbiology; D017576:Daptomycin; D004917:Erythromycin / Q000494:pharmacology; D024841:Fluoroquinolones; D006020:Glycopeptides / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D010455:Peptides / Q000494:pharmacology*; D015363:Quinolones / Q000494:pharmacology; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects*; D017334:Teicoplanin; D014640:Vancomycin / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D006020:Glycopeptides; D010455:Peptides; D015363:Quinolones; C059911:SK&F 104662; C054745:temafloxacin; D017334:Teicoplanin; D004917:Erythromycin; D014640:Vancomycin; D017576:Daptomycin