title: Carbon dioxide inhalation reduces the function of GABAA receptors in the rat brain.
abstract: The effect of CO2 inhalation on the function of the GABA(A)-coupled chloride channel was evaluated in rat brain. This treatment decreased the capability of GABA to stimulate 36Cl- uptake and produced a significant increase of [35S]-TBPS ([35S]t-butylbicyclophosphorothionate) binding in the cerebral cortex, cerebellum and hippocampus. These results demonstrate that a brief exposure of rats to CO2 inhalation reduces the function of the GABA(A)-ionophore receptor complex in rat brain.
authors.affiliation: Department of Experimental Biology, University of Cagliari, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Sanna
authors.forename: T
authors.initials: T
authors.lastname: Cuccheddu
authors.forename: M
authors.initials: M
authors.lastname: Serra
authors.forename: A
authors.initials: A
authors.lastname: Concas
authors.forename: G
authors.initials: G
authors.lastname: Biggio
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001643:Bridged Bicyclo Compounds / Q000378:metabolism; D019086:Bridged Bicyclo Compounds, Heterocyclic; D002245:Carbon Dioxide / Q000008:administration & dosage / Q000494:pharmacology*; D002531:Cerebellum / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000187:drug effects*
chemical_list: D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D011963:Receptors, GABA-A; D002245:Carbon Dioxide; C037476:tert-butylbicyclophosphorothionate