[Enalapril and myocardial protection from stress by cold].
OBJECTIVE
To evaluate the myocardial protective effect of enalaprilat in rats submitted to stress by cold.


METHODS
Fifteen adults, male rats were studied. They were allocated into four groups: group A received unrestricted diet + intraperitoneal (IP) diluent; group B: unrestricted diet + IP enalaprilat 1.0 mg/kg; group C: high salt diet (HD) for seven days + IP indomethacin 1.0 mg/kg and group D received high salt diet for seven days + IP indomethacin 1.0 mg/kg + IP enalaprilat 1.0 mg/kg. Three animals were the control group. The animals of the groups A, B, C and D were then submitted to stress by cold. Fragments of the left ventricle were obtained for electron microscopy and the occurrence of mitochondrial lysis or preservation of the mitochondrial ultrastructure were considered as parameter for myocardial protective effect evaluation.


RESULTS
Crystolysis (partial or total) was observed in 16.2% group A; 19.5% of group C; 3.2% of group B and in 8.8% of group D.


CONCLUSIONS
Enalaprilat protects the cardiomyocyte from the stress by cold.
Ferreira
C
C
Escola Paulista de Medicina, São Paulo.
Póvoa
R
R
Kasinski
N
N
Murad
N
N
Mosa
O
O
Ferreira Filho
C
C
Ferreira
M
M
D000818:Animals; D003080:Cold Temperature / Q000009:adverse effects*; D004656:Enalapril / Q000494:pharmacology*; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects / Q000648:ultrastructure*; D009206:Myocardium; D051381:Rats; D013312:Stress, Physiological / Q000150:complications / Q000209:etiology*
D004656:Enalapril
Enalapril e proteção do miocárdio ao estresse pelo frio.