[Overall analysis of structural factors responsible for the activity and toxicity of antiparasitic agents used in therapy].
A mini-data bank was constituted from the 73 french antiparasitic patent medicines and was implanted in microcomputer. A maximum of chemical, pharmaceutical, therapeutical and toxicological data were collected and treated by multivariate analysis. Exploitation of these informations processing allows to take out correlations between chemical structure toxicity, and specificity.
Lacroix
J
J
Faculté de Pharmacie, Tours, France.
Dore
J C
JC
Viel
C
C
Lacroix
R
R
Beliveau
F
F
Reynouard
F
F
D000871:Anthelmintics / Q000009:adverse effects* / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000009:adverse effects* / Q000494:pharmacology; D006801:Humans; D013329:Structure-Activity Relationship
D000871:Anthelmintics; D000981:Antiprotozoal Agents
Analyse globale des facteurs structuraux responsables de l'activité et de la toxicité des antiparasitaires utilisés en thérapeutique.