[Effects of zinc overdose on the viscera and tissue pathomorphology].
This investigation included two toxic animal models of zinc: acute and subacute. In the subacute model, ultrastructural changes occurred and zinc content of the liver and kidney increased when the concentration of serum zinc was not obviously changed. In the acute model, the functions of the liver, kidney and cell immunity were impaired, and marked ultrastructural changes noted. The results showed that long-term use of zinc or overdose is dangerous, although zinc is considered of lower toxicity as compared to other heavy metal elements. It is suggested that zinc should be used carefully in children.
Chen
R
R
Nanjing Medical College.
D000818:Animals; D062787:Drug Overdose; D007111:Immunity, Cellular / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000473:pathology* / Q000648:ultrastructure; D008099:Liver / Q000187:drug effects / Q000473:pathology* / Q000648:ultrastructure; D051381:Rats; D015032:Zinc / Q000097:blood / Q000506:poisoning*
D015032:Zinc