title: Acute respiratory failure during pneumonia induced by Sendai virus.
abstract: In this study a model of acute respiratory failure due to viral pneumonia in rats, closely resembling ARDS, is presented. Severe respiratory failure with lethal outcome in four days was induced by infection concentrated Sendai virus aerosol. This model permits evaluation of different therapeutical approaches for improving gas exchange during ARDS. Furthermore, preliminary results of surfactant substitution therapy in this model are presented.
authors.affiliation: Dept of Anesthesiology, Erasmus University Rotterdam, The Netherlands.
authors.forename: G J
authors.initials: GJ
authors.lastname: van Daal
authors.forename: E P
authors.initials: EP
authors.lastname: Eijking
authors.forename: K L
authors.initials: KL
authors.lastname: So
authors.forename: R B
authors.initials: RB
authors.lastname: Fievez
authors.forename: M J
authors.initials: MJ
authors.lastname: Sprenger
authors.forename: D W
authors.initials: DW
authors.lastname: van Dam
authors.forename: W
authors.initials: W
authors.lastname: Erdmann
authors.forename: B
authors.initials: B
authors.lastname: Lachmann
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D008297:Male; D010222:Parainfluenza Virus 1, Human / Q000472:pathogenicity*; D018184:Paramyxoviridae Infections / Q000209:etiology*; D011024:Pneumonia, Viral / Q000209:etiology*; D011659:Pulmonary Gas Exchange / Q000187:drug effects; D011663:Pulmonary Surfactants / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D012128:Respiratory Distress Syndrome / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D012131:Respiratory Insufficiency / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology
chemical_list: D011663:Pulmonary Surfactants