title: Tissue reaction to bone-anchored percutaneous implants in rabbits.
abstract: It has been demonstrated that direct attachment to bony skeletal tissues favors the longevity of percutaneous devices (PDs). This study is focused on improvement of the success rates by using a two-stage implantation technique. For this purpose, cylindrical-shaped PDs were inserted into the tibia of rabbits. The enossal part of the implants was made of Ti6Al4V and was coated with a layer hydroxyapatite (HA). The percutaneous part was made of dense HA. In a first surgical session, the enossal part of the implants was inserted. In a second implantation session, about 3 months later, the percutaneous part was fixed into the enossal part. The implants were left in situ for 5 months after the second session. Clinical and histological investigations were performed. The results confirmed the previous finding--that bone anchoring is effective in the maintenance of a permanent percutaneous passage. On the other hand, it could not be proven that a two-stage implantation procedure improves the success rate of one-stage bone-anchored PDs.
authors.affiliation: Department of Biomaterials, School of Medicine, University of Leiden, The Netherlands.
authors.forename: J A
authors.initials: JA
authors.lastname: Jansen
authors.forename: J P
authors.initials: JP
authors.lastname: van der Waerden
authors.forename: K
authors.initials: K
authors.lastname: de Groot
mesh_terms: D000818:Animals; D017886:Durapatite; D006882:Hydroxyapatites; D019736:Prostheses and Implants; D011817:Rabbits; D013977:Tibia / Q000166:cytology / Q000601:surgery*; D014025:Titanium; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology*
chemical_list: D006882:Hydroxyapatites; D017886:Durapatite; D014025:Titanium