title: Alterations in endothelium-associated proteins and serum thyroid hormone concentrations in anorexia nervosa.
abstract: Plasma concentrations of endothelium-associated proteins (EAP) (plasma fibronectin (PFN), angiotensin-converting enzyme, factor VIII-related antigen (F VIII-R:Ag)) and tissue plasminogen activator and serum thyroid hormone concentrations were studied in nine patients with anorexia nervosa (AN), before and after weight gain. Before weight gain (-35.9 (SE 2.3)% of standard body-weight) PFN was significantly reduced and F VIII-R:Ag was significantly increased in AN patients compared with the concentrations in control subjects (211.5 (SE 14.9) v. 274.7 (SE 16.6) micrograms/ml, P < 0.05; 129.2 (SE 14.1) v. 88.2 (SE 9.7) %, P < 0.05 respectively). Serum triiodothyronine (T3) and free T3 levels were also significantly lower before weight gain in AN patients (0.85 (SE 0.07) v. 1.53 (SE 0.08) nmol/l, P < 0.001; 2.57 (SE 0.23) v. 5.31 (SE 0.34) pmol/l, P < 0.001 respectively), although serum thyroxine (T4), free T4, and thyrotropin concentrations were within the normal range throughout the study periods. Following weight gain, PFN and F VIII-R:Ag concentrations normalized as did the thyroid hormone levels. The incremental changes in PFN levels correlated significantly with those in serum thyroid hormone concentrations (T3, r 0.79, P < 0.01; free T3, r 0.84, P < 0.01). These findings suggest that PFN levels may be directly related to serum T3 concentrations in AN patients.
authors.affiliation: Department of Psychosomatic Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: G
authors.initials: G
authors.lastname: Komaki
authors.forename: H
authors.initials: H
authors.lastname: Tamai
authors.forename: T
authors.initials: T
authors.lastname: Mukuta
authors.forename: N
authors.initials: N
authors.lastname: Kobayashi
authors.forename: K
authors.initials: K
authors.lastname: Mori
authors.forename: T
authors.initials: T
authors.lastname: Nakagawa
authors.forename: L F
authors.initials: LF
authors.lastname: Kumagai
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000097:blood*; D004730:Endothelium, Vascular / Q000378:metabolism*; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D013963:Thyroid Hormones / Q000097:blood; D010959:Tissue Plasminogen Activator / Q000097:blood; D014284:Triiodothyronine / Q000097:blood*; D015430:Weight Gain / Q000502:physiology; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D005353:Fibronectins; D013963:Thyroid Hormones; D014841:von Willebrand Factor; D014284:Triiodothyronine; D007703:Peptidyl-Dipeptidase A; D010959:Tissue Plasminogen Activator