[The degree of tumor vascularization as a prognostic factor of the efficacy of neoadjuvant polychemotherapy in breast cancer].
A procedure for obtaining microcirculation coefficient is described. It is based on the phenomenon of formation of a focus of radionuclide hyperfixation on scintigrams of tumor area due to embolization of its arterioles and precapillaries with radionuclide. The method was used in 26 breast cancer patients before neoadjuvant chemotherapy. A direct correlation between the microcirculation coefficient and degree of tumor-induced pathomorphosis of tumor cells was established. The coefficient values proved more or less predictive of tumor response to chemotherapy.
Voznyĭ
E K
EK
Biakhov
M Iu
MIu
Gorb
A I
AI
Krivenko
E V
EV
Chkhikvadze
V D
VD
Alipchenko
L A
LA
Agrinskaia
I A
IA
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004341:Drug Evaluation; D004621:Embolization, Therapeutic; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008833:Microcirculation / Q000000981:diagnostic imaging; D008875:Middle Aged; D011379:Prognosis; D011877:Radionuclide Imaging; D013670:Sodium Pertechnetate Tc 99m; D013997:Time Factors
D004317:Doxorubicin; D003520:Cyclophosphamide; D013670:Sodium Pertechnetate Tc 99m; D005472:Fluorouracil
Stepen' vaskuliarizatsii opukholi kak prognosticheskiĭ faktor éffektivnosti neoad''iuvantnoĭ polikhimioterapii pri rake molochnoĭ zhelezy.