title: [An electron microscopic study of the behavioral characteristics of human lung tumor cells cultured on soft agar].
abstract: The ultrastructure of cells from seven human lung cancers and from the colonies formed by these cells in soft agar was investigated. Tumor cells developed to display the morphofunctional potentials of the initial tumors. Cultured cells of squamous-cell carcinomas contained numerous tonofilaments, those of adenocarcinomas developed microvilli on their apical surfaces and intracellular lumens. On the other hand, cells of squamous-cell carcinomas showed features specific of adenoma epithelium, i.e. well developed microvilli and intracellular lumens. Besides, cells of adenocarcinoma often contained large quantities of tonofilaments considered to be characteristic of epidermoid epithelium. The results obtained suggest a possibility of metaplastic transformation of the lung epithelium.
authors.forename: S O
authors.initials: SO
authors.lastname: Semiachkina
authors.forename: V F
authors.initials: VF
authors.lastname: Klimashevskiĭ
authors.forename: K M
authors.initials: KM
authors.lastname: Pozharisskiĭ
mesh_terms: D000230:Adenocarcinoma / Q000648:ultrastructure*; D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000648:ultrastructure*; D000362:Agar; D002294:Carcinoma, Squamous Cell / Q000648:ultrastructure*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000648:ultrastructure; D003470:Culture Media; D006801:Humans; D008175:Lung Neoplasms / Q000648:ultrastructure*; D008727:Methotrexate / Q000494:pharmacology; D008854:Microscopy, Electron; D009024:Morphogenesis / Q000187:drug effects; D011447:Prospidium / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000648:ultrastructure; D014750:Vincristine / Q000494:pharmacology
chemical_list: D003470:Culture Media; D014750:Vincristine; D011447:Prospidium; D000362:Agar; D008727:Methotrexate
vernacular_title: Elektronno-mikroskopicheskoe issledovanie osobennosteĭ povedeniia kletok opukholeĭ legkogo cheloveka, kul'tiviruemykh v miagkom agare.