Synthesis and biological studies of neutral technetium (V) complexes containing NNOS donor sets.
Complexation of ligands containing an N3S donor set has been affected with [99mTc]. These are part of a ligand series of analogous structures which exhibit similar chemistry and potentially interesting biology. The complexes which have been characterized with [99Tc] as [TcOL] are neutral and lipophilic and their biological behaviour has been assessed in rats. After HPLC purification of the no-carrier added preparation, brain uptake of the tracers was greater than 1% at 15 min p.i. Muscle activity was significant with slow blood clearance.
Morgan
G F
GF
R/D Imaging, Medgenix Group, Fleurus, Belgium.
Deblaton
M
M
van den Broeck
P
P
Bastin
B
B
Pirotte
R
R
Michel
P
P
Clemens
P
P
Abram
U
U
Thornback
J R
JR
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D001921:Brain / Q000000981:diagnostic imaging*; D005260:Female; D008024:Ligands; D011485:Protein Binding; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D013670:Sodium Pertechnetate Tc 99m / Q000737:chemistry; D013438:Sulfhydryl Compounds; D013667:Technetium; D014018:Tissue Distribution
D001798:Blood Proteins; D008024:Ligands; D013438:Sulfhydryl Compounds; D013667:Technetium; D013670:Sodium Pertechnetate Tc 99m