Role of thyroid hormone in intermediary metabolism of propranolol or alloxan-treated Calotes versicolor.
Administration of L-thyroxine (T4) to thyroidectomized Calotes versicolor significantly increased the activity of glucose-6-phosphatase (G-6-Pase) (liver and kidney), the concentrations of blood glucose and total protein (liver and kidney), and decreased hepatic cholesterol when compared to thyroidectomized lizards. Propranolol injections in thyroidectomized lizards increased the cholesterol concentration and did not change the other parameters. The activity of G-6-Pase and blood glucose content was stimulated, whereas the total protein and cholesterol contents were decreased after alloxan treatment. Administration of T4 to thyroidectomized animals pretreated with propranolol or alloxan significantly elevated the activity of G-6-Pase, the concentrations of blood glucose, and total protein, and reduced hepatic cholesterol level when compared to drug-treated lizards. From the results, it is evident that thyroid hormone has an independent stimulatory influence on intermediary metabolism in C. versicolor irrespective of the involvement of adrenaline or insulin.
Jacob
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Department of Zoology, University of Kerala, Trivandrum, India.
Oommen
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OV
D000496:Alloxan / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D004837:Epinephrine / Q000378:metabolism; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008116:Lizards; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D013965:Thyroidectomy; D013974:Thyroxine / Q000378:metabolism* / Q000494:pharmacology
D001786:Blood Glucose; D007328:Insulin; D000496:Alloxan; D002784:Cholesterol; D011433:Propranolol; D005952:Glucose-6-Phosphatase; D013974:Thyroxine; D004837:Epinephrine