[Multiple resistance to drugs by MRSA].
Most methicillin-resistant Staphylococcus aureus (MRSA) isolates are multiply resistant to various antimicrobial agents. Therefore, MRSA strains have become a serious problem in the clinical setting. However, it should be noted that the frequency of isolation of strains resistant to aminoglycoside and minocycline was not significantly different between low- and high-MRSA isolates and the isolation frequency of high-MRSA strains, less susceptible to not only beta-lactam antibiotics but also to macrolide antibiotics and quinolones, was significantly higher than the corresponding values for low-MRSA strains. These results suggest that high-MRSA strains were selected by antimicrobial agents for the treatment with the patients.
Inoue
M
M
Department of Microbiology, Kitasato University, School of Medicine.
Hasobe
N
N
Hirata
Y
Y
Okubo
T
T
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004352:Drug Resistance, Microbial / Q000235:genetics*; D018942:Macrolides; D016106:Methicillin Resistance; D015363:Quinolones / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000235:genetics*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D018942:Macrolides; D015363:Quinolones