Effect of flunisolide on nasal eosinophils and IgE, and symptom score in children with allergic rhinitis.
We evaluated the effect of treatment with flunisolide nasal spray (100 micrograms/day for 3 months) in 24 children with allergic rhinitis on the following parameters: clinical symptoms, absolute number of peripheral and nasal eosinophils, and total IgE levels in nasal secretion. Therapy with flunisolide induced a significant reduction of clinical symptoms (p < 0.001), nasal eosinophils (p < 0.001) and nasal IgE concentration (p < 0.02), while it did not affect the number of peripheral eosinophils. These results indicate that flunisolide can reduce the allergic inflammation of the nasal mucosa.
Cantani
A
A
Department of Pediatrics, University of Roma La Sapienza, Italy.
Paganelli
R
R
Meglio
P
P
Ferrara
M
M
Fameles-Belasio
E
E
Businco
L
L
D000281:Administration, Intranasal; D000287:Administration, Topical; D000293:Adolescent; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004804:Eosinophils / Q000187:drug effects*; D005260:Female; D005446:Fluocinolone Acetonide / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D007073:Immunoglobulin E / Q000378:metabolism*; D007958:Leukocyte Count; D008297:Male; D008925:Mites / Q000276:immunology; D009297:Nasal Mucosa / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology
D000893:Anti-Inflammatory Agents; D005446:Fluocinolone Acetonide; D007073:Immunoglobulin E; C007734:flunisolide