[Osmotic actions on the epithelial Na,K pump of the small intestine].
Intragastric administration of mannitol or NaCl hypotonic solution induced a significant shift of the electrolyte balance in the small intestine epithelium, and activated the enterocytes' Na,K pump in Wistar rats. De-ionised water caused the maximal enhancement of the Na,K-ATPase activity, whereas hypertonic solutions exerted the opposite effect, a substance-inhibitor appearing in the blood serum. Similar results were obtained in vitro. The possibility of the Na,K-pump regulation by enterocytes and the role of small intestine in secretion of an endogenous factor regulating this enzyme's activity, is discussed.
Iaremenko
M S
MS
Prokopenko
O N
ON
Kharlamova
O N
ON
Vavilova
G L
GL
D000818:Animals; D004848:Epithelium / Q000187:drug effects / Q000201:enzymology / Q000502:physiology; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000187:drug effects / Q000201:enzymology / Q000502:physiology*; D007421:Intestine, Small / Q000187:drug effects / Q000201:enzymology / Q000502:physiology*; D008353:Mannitol / Q000494:pharmacology; D009994:Osmolar Concentration; D051381:Rats; D017208:Rats, Wistar; D012965:Sodium Chloride / Q000494:pharmacology; D000254:Sodium-Potassium-Exchanging ATPase / Q000032:analysis / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors; D014867:Water / Q000494:pharmacology; D014882:Water-Electrolyte Balance / Q000187:drug effects / Q000502:physiology
D014867:Water; D008353:Mannitol; D012965:Sodium Chloride; D000254:Sodium-Potassium-Exchanging ATPase
Osmoticheskie vozdeĭstviia na Na,K-nasos épiteliia tonkoĭ kishki.