title: Treatment of HIV infection: the antiretroviral nucleoside analogues. Nucleoside analogues: combination therapy.
abstract: Combination antiretroviral therapy is an important development in the management of HIV infection. AZT with ddC is the first such combination to be approved for clinical use. Several issues remain, however, including the precise clinical benefit and toxicity of combination therapy, its effect on drug resistance, and the development of ever more effective therapeutic strategies.
authors.affiliation: Harvard University.
authors.forename: G X
authors.initials: GX
authors.lastname: McLeod
authors.forename: S M
authors.initials: SM
authors.lastname: Hammer
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D000998:Antiviral Agents / Q000627:therapeutic use*; D016049:Didanosine / Q000008:administration & dosage; D004341:Drug Evaluation; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D016047:Zalcitabine / Q000008:administration & dosage / Q000009:adverse effects / Q000037:antagonists & inhibitors; D015215:Zidovudine / Q000008:administration & dosage / Q000009:adverse effects / Q000037:antagonists & inhibitors
chemical_list: D000998:Antiviral Agents; D015215:Zidovudine; D016047:Zalcitabine; D016049:Didanosine