title: Benign mixed tumor of canine mammary gland showing an r(X) and trisomy 5 as the only clonal abnormalities.
abstract: We report a benign mixed tumor of the canine mammary gland which showed an r(X) and trisomy 5 as the only clonal karyotypic deviations. Clonal aberrations were observed in 79 of 160 of the metaphases. Of these, 48 cells had both the r(X) and trisomy 5, whereas the remaining metaphases were characterized by the r(X) as the only clonal aberration. We conclude that formation of the ring chromosome was the first abnormality, followed by trisomy 5 during the course of karyotypic evolution.
authors.affiliation: Center of Human Genetics and Genetic Counselling, University of Bremen, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Bartnitzke
authors.forename: H
authors.initials: H
authors.lastname: Motzko
authors.forename: C
authors.initials: C
authors.lastname: Rosenhagen
authors.forename: J
authors.initials: J
authors.lastname: Bullerdiek
mesh_terms: D000818:Animals; D004285:Dogs; D007621:Karyotyping; D015674:Mammary Neoplasms, Animal / Q000235:genetics*; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics / Q000662:veterinary*; D012303:Ring Chromosomes; D012729:Sex Chromosome Aberrations; D014314:Trisomy; D014960:X Chromosome