[Morphometrical analysis of non-cancerous liver tissue with special reference to clinicopathological features of hepatocellular carcinoma].
This study was undertaken to investigate the relationship between morphometrical characteristics of noncancerous liver tissues and clinicopathological features of hepatocellular carcinoma (HCC) in 89 cases which underwent either hepatectomy (n = 56) or autopsy (n = 33). Using Automatic Image Analyzer (IBAS-2), we determined interstitial ratio (IR) of the non-cancerous liver tissues as a morphological parameter in all cases. In addition, mean values of area (MA), maximal diameter, and shape factor of pseudolobules were determined in the cirrhotic patients. IR in cases with main tumors smaller than 3 cm was higher than that in cases with tumors larger than 3 cm (23.5 +/- 6.7% vs 18.5 +/- 8.9% mean +/- SD: p less than 0.01), and IR in cases with histologically proven intrahepatic metastases (im positive) was also higher as compared to im negative cases (17.5 +/- 9.0% vs 21.3 +/- 8.0%; p less than 0.05). Among the other parameters determined in the cirrhotics, MA was higher in cases with tumors larger than 3 cm than in cases with smaller tumors (2.54 +/- 1.87 mm2 vs 1.78 +/- 1.01 mm2; p less than 0.05), and MA was higher in im positive cases as compared to im negatives (2.67 +/- 1.91 mm2 vs 1.67 +/- 0.96 mm2; p less than 0.01). These data indicated that non-cancerous liver tissue has a close relation not only to the carcinogenesis but to subsequent tumor growth and progression of HCC.
Iwasaki
T
T
First Department of Surgery, Kobe University School of Medicine, Japan.
Ku
Y
Y
Saito
Y
Y
Ito
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000473:pathology* / Q000601:surgery; D005260:Female; D006498:Hepatectomy; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000150:complications / Q000473:pathology; D008113:Liver Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged