Near-haploid clones in a malignant fibrous histiocytoma.
Near-haploid solid tumors are very rare. In a storiform-pleomorphic malignant fibrous histiocytoma (MFH) of bone, we found three cell populations: one with a near-haploid, a second with a near-diploid, and a third with a near-tetraploid chromosome number. The near-haploid cells had few structural rearrangements: i(12p) and t(13q21q) in one clone, and these two and an additional t(19;?)(p11;?) in another clone. One structurally normal copy of all chromosomes was also present, except that the only chromosome 13 was involved in the t(13q21q). There were also two near-diploid clones, one without the t(19;?) and one with a single copy of this derivative chromosome. This is the first tumor with i(12p) among bone and soft tissue tumors.
Orndal
C
C
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Mandahl
N
N
Carlén
B
B
Willén
H
H
Wennerberg
J
J
Heim
S
S
Mitelman
F
F
D007446:Chromosome Inversion; D002881:Chromosomes, Human, Pair 12; D005260:Female; D006238:Haploidy; D018219:Histiocytoma, Benign Fibrous / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D008339:Mandibular Neoplasms / Q000235:genetics* / Q000473:pathology; D008854:Microscopy, Electron; D008875:Middle Aged; D014407:Tumor Cells, Cultured