title: Immunoglobulin-complexed aspartate aminotransferase with a possible association with ulcerative colitis and its activity.
abstract: We demonstrate immunoglobulin-complexed aspartate aminotransferase (macro-AST) in a 14-year-old boy with rectitis-type ulcerative colitis by using both gel filtration and electrophoresis methods. The immunoglobulin complexed with AST in this case was identified as an IgG kappa both by electrosyneresis and immunoprecipitation reactions. The present case was noted to have a concomitant elevation of macro-AST associated with deterioration of ulcerative colitis. However, macro-AST has continued to exist when the activity of ulcerative colitis subsided, and the serum level of AST became normal. Thus, macro-AST might be related to an immunological component of ulcerative colitis as well as to the activity of the disease.
authors.affiliation: Department of Pediatrics, Osaka University Hospital, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tajiri
authors.forename: T
authors.initials: T
authors.lastname: Nakano
authors.forename: K
authors.initials: K
authors.lastname: Kozaiwa
authors.forename: T
authors.initials: T
authors.lastname: Harada
authors.forename: S
authors.initials: S
authors.lastname: Okada
authors.forename: R
authors.initials: R
authors.lastname: Fushimi
authors.forename: N
authors.initials: N
authors.lastname: Amino
authors.forename: K
authors.initials: K
authors.lastname: Miyai
mesh_terms: D000293:Adolescent; D001219:Aspartate Aminotransferases / Q000378:metabolism*; D002850:Chromatography, Gel; D003093:Colitis, Ulcerative / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D046911:Macromolecular Substances; D008297:Male; D011233:Precipitin Tests; D011485:Protein Binding
chemical_list: D007074:Immunoglobulin G; D046911:Macromolecular Substances; D001219:Aspartate Aminotransferases