[Myocardial beta-adrenergic receptors and left ventricular hypertrophy induced by pressure overload in man].
In experimental models, the characteristics of beta-adrenoceptors in left ventricular hypertrophy (LVH) due to pressure overload remain controversial and no data are still available in man. We investigated right auricular (RA) and left ventricular (LV) beta-adrenoceptors characteristics (125 I cyanopindolol binding) in two groups of patients undergoing valve replacement without heart failure (LV ejection fraction > 55%). Height patients with mitral stenosis (mean age: 64 +/- 4 years) and without LVH (LV mass index < 120 g/m2) constituted the control group and 13 patients with aortic stenosis (mean age: 66 +/- 4 years) and LVH (LV mass index > 150 g/m2) the study group. The results are: [table: see text] These results show that, in man, LVH due to pressure overload does not induce variation of total number beta-adrenoceptors, but is associated with a selective decrease in left ventricular beta 1-adrenoceptors.
Galinier
M
M
Laboratoire de pharmacologie médicale et clinique, INSERM U317, faculté de médecine, Toulouse.
Sénard
J M
JM
Dréan
G
G
Valet
P
P
Glock
Y
Y
Dalous
P
P
Roux
D
D
Puel
J
J
Montastruc
J L
JL
Bounhoure
J P
JP
D000368:Aged; D002395:Catecholamines / Q000097:blood; D015536:Down-Regulation; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000032:analysis*; D013564:Sympathetic Nervous System / Q000503:physiopathology
D002395:Catecholamines; D011943:Receptors, Adrenergic, beta
Récepteurs bêta-adrénergiques myocardiques et hypertrophie ventriculaire gauche induite par une surcharge barométrique chez l'homme.