title: Evidence for distinct neuronal localization of gamma and delta subunits of Ca2+/calmodulin-dependent protein kinase II in the rat brain.
abstract: Localization of the gamma and delta types of mRNAs for Ca2+/calmodulin-dependent protein kinase II (CaM-kinase II) was determined in the rat brain, making use of in situ hybridization histochemistry. The gamma and delta mRNAs as well as the alpha and beta mRNAs for CaM-kinase II were heterogeneously and distinctly distributed. In the Purkinje cell layer of the cerebellum, alpha, beta, and gamma mRNAs but not delta mRNA were present, whereas beta, gamma, and delta mRNAs were present in the locus coeruleus. These findings provide evidence that CaM-kinase II exists in a variety of forms in different cells composed of a variable number and type of subunits.
authors.affiliation: Department of Pharmacology, Kobe University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Takaishi
authors.forename: N
authors.initials: N
authors.lastname: Saito
authors.forename: C
authors.initials: C
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000201:enzymology*; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D006651:Histocytochemistry; D009474:Neurons / Q000201:enzymology*; D009693:Nucleic Acid Hybridization; D011494:Protein Kinases / Q000737:chemistry / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D014018:Tissue Distribution
chemical_list: D012333:RNA, Messenger; D011494:Protein Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases