title: Non-Hodgkin's lymphoma associated with primary Sjögren's syndrome.
abstract: OBJECTIVE
  To evaluate the prevalence, the incidence and clinical presentation of non-Hodgkin's lymphoma associated with primary Sjögren's syndrome.
  
  
  METHODS
  Sixty-two patients with primary Sjögren's syndrome were analyzed retrospectively in an open investigation.
  
  
  RESULTS
  Of 62 patients with primary Sjögren's syndrome, 4 of them (6.4%) developed non-Hodgkin's lymphoma (6.9 cases per 1000 per year). All of them were women. Non-Hodgkin's lymphoma always developed after the onset of primary Sjögren's syndrome with a time interval ranging from 3 to 27 years. Pathological findings showed two diffused mixed small and large cell cleaved lymphomas and two diffused large cell cleaved lymphomas. Three cases had extra-nodular localizations. All of these 4 patients are still alive and in complete remission 2 to 8 years after the diagnosis of non-Hodgkin's lymphoma.
  
  
  CONCLUSIONS
  This study confirms the association of non-Hodgkin's lymphoma in primary Sjögren's syndrome. These non-Hodgkin's lymphomas frequently had extra-nodal localizations. Good sensitivity to treatment, when necessary, provided good prognosis.
authors.affiliation: Service d'Immuno-Rhumatologie, Centre Gui-de-Chauliac, Hôpital Saint-Eloi, Montpellier, France.
authors.forename: D
authors.initials: D
authors.lastname: Pariente
authors.forename: J M
authors.initials: JM
authors.lastname: Anaya
authors.forename: B
authors.initials: B
authors.lastname: Combe
authors.forename: C
authors.initials: C
authors.lastname: Jorgensen
authors.forename: J M
authors.initials: JM
authors.lastname: Emberger
authors.forename: J F
authors.initials: JF
authors.lastname: Rossi
authors.forename: J
authors.initials: J
authors.lastname: Sany
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001327:Autoimmune Diseases / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012859:Sjogren's Syndrome / Q000150:complications* / Q000453:epidemiology / Q000473:pathology