[Cytomegalovirus infections in patients after liver transplantation: determination of risk groups].
The goal of this study was to identify high-risk groups for cytomegalovirus infection after liver transplantation. Sixty-one patients were evaluated. Twenty-five patients (41 percent) had infection. Among the 16 patients who were seronegative for the virus before transplantation, 11 received a liver graft and blood products from seronegative donors and none of them developed infection. All seronegative recipients of a liver from seropositive donors (5/5) developed primary infection. Among the 45 patients seropositive before transplantation, 20 developed a cytomegalovirus infection, whatever the donor serologic status. The incidence of symptomatic reactivation or reinfection was high (14/20), and, for 12/14 of them, associated with early acute rejection. Two high-risk groups of patients, eligible for cytomegalovirus prophylaxis, were identified: seronegative recipients of seropositive donors and seropositive recipients with early acute rejection.
Vigouroux
C
C
Département d'Anesthésie-Réanimation, Groupe Hospitalier Cochin, Paris.
Moncorgé
C
C
Calmus
Y
Y
Matmar
M
M
Baudin
F
F
Garnier
J F
JF
Archambeau
D
D
Ozier
Y
Y
Lebon
P
P
Houssin
D
D
D000293:Adolescent; D000328:Adult; D003586:Cytomegalovirus Infections / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality / Q000517:prevention & control; D005500:Follow-Up Studies; D015774:Ganciclovir / Q000627:therapeutic use; D006801:Humans; D007108:Immune Tolerance; D015994:Incidence; D016031:Liver Transplantation / Q000009:adverse effects*; D008875:Middle Aged; D012008:Recurrence; D012307:Risk Factors; D065227:Transfusion Reaction
D015774:Ganciclovir
Infections à cytomégalovirus chez les transplantés hépatiques: détermination de groupes à risque.