[Experimental study on the effect of injection with anticancer agent-oil suspension].
Local injection of an anticancer agent guided by endoscopy is thought to be effective for cancerous lesion associated with lymph node metastasis, if the anticancer drugs are drained into the lymph nodes. In the experimental study, anticancer drug-oil (nimustine-Lipiodol) (N-L) suspension (5 mg/ml) was injected into the tumor (Lewis lung cancer) that had been implanted sub dorsally in mice (57 black/6 mice) for the purpose of finding out the antitumor effect on the primary lesion. Then it was injected into sarcoma-180 that had been implanted into hind feet of mice (ICR mice) for the purpose of finding out the antitumor effect on metastatic lymph nodes. The results showed that the N-L suspension was effective for the primary cancerous lesion and metastatic lesions.
Otaki
S
S
Dept. of Surgery, Teikyo University Hospital at Mizonokuchi.
Kaneko
H
H
Fukuma
E
E
Yamakawa
T
T
D000818:Animals; D004317:Doxorubicin / Q000008:administration & dosage* / Q000494:pharmacology; D015552:Injections, Intralesional; D007459:Iodized Oil / Q000008:administration & dosage* / Q000494:pharmacology; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008198:Lymph Nodes / Q000187:drug effects*; D008207:Lymphatic Metastasis; D051379:Mice; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D016685:Mitomycin / Q000008:administration & dosage* / Q000494:pharmacology; D015376:Nimustine / Q000008:administration & dosage* / Q000494:pharmacology; D012513:Sarcoma, Experimental / Q000188:drug therapy* / Q000473:pathology
D015376:Nimustine; D016685:Mitomycin; D007459:Iodized Oil; D004317:Doxorubicin