A novel reciprocal chromosome translocation t(11;22)(p13;q12) in an intraabdominal desmoplastic small round-cell tumor.
We report an intraabdominal desmoplastic small round-cell tumor that contains a novel reciprocal chromosome translocation t(11;22)(p13;q12). The tumor showed a reciprocal chromosome translocation which is different from the (11;22)(q24;q12) translocations seen in Ewing's and other small-cell tumors but affects the same break-point on chromosome 22(q12). This reciprocal chromosome translocation may prove to be a marker for intraabdominal desmoplastic small round-cell tumors.
Sawyer
J R
JR
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock.
Tryka
A F
AF
Lewis
J M
JM
D000008:Abdominal Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D000293:Adolescent; D014408:Biomarkers, Tumor / Q000235:genetics; D018288:Carcinoma, Small Cell / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D002880:Chromosomes, Human, Pair 11; D002892:Chromosomes, Human, Pair 22; D005260:Female; D006801:Humans; D007621:Karyotyping; D014178:Translocation, Genetic / Q000235:genetics*
D014408:Biomarkers, Tumor