The effect of contraceptives containing nonoxynol-9 on the genital transmission of simian immunodeficiency virus in rhesus macaques.
The ability of two nonoxynol-9 spermicide preparations to prevent the genital transmission of SIV in rhesus macaques was compared. Administration of one mL of contraceptive foam before the intravaginal inoculation of cell-free SIV prevented the genital transmission of SIV to three of six animals, and using one mL of contraceptive gel prevented the genital transmission of SIV to two of six animals. Thus, both contraceptive foams and gels containing nonoxynol-9 provided protection against the genital transmission of SIV.
Miller
C J
CJ
California Regional Primate Research Center, University of California, Davis 95616.
Alexander
N J
NJ
Gettie
A
A
Hendrickx
A G
AG
Marx
P A
PA
D000818:Animals; D005260:Female; D008253:Macaca mulatta; D008297:Male; D017137:Nonoxynol; D011092:Polyethylene Glycols / Q000494:pharmacology* / Q000627:therapeutic use; D012749:Sexually Transmitted Diseases / Q000517:prevention & control; D016097:Simian Acquired Immunodeficiency Syndrome / Q000517:prevention & control / Q000635:transmission*; D015302:Simian Immunodeficiency Virus / Q000187:drug effects*; D013089:Spermatocidal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D014621:Vagina
D013089:Spermatocidal Agents; D017137:Nonoxynol; D011092:Polyethylene Glycols