title: CA-125, placental alkaline phosphatase and tissue polypeptide antigen as preoperative serum markers in ovarian carcinoma.
abstract: Blood samples were drawn before laparotomy in 42 cases of benign, 17 cases of borderline, and 53 cases of malignant epithelial ovarian neoplasms. The concentrations of CA-125, tissue polypeptide antigen, and placental alkaline phosphatase (PLAP) were determined. No significant difference was found between the levels of CA-125 and TPA. No significant correlation was seen between tumour type and these two markers; however, both were significantly correlated to tumour malignancy and clinical stage, and CA-125 was also correlated to tumour grade. No correlation was found between PLAP and the other markers or any of the above-mentioned parameters. If at least one of two or three markers was requested to be positive, a moderate increase in the 'detection rate' of malignant tumours was found. However, the rate of positive benign samples increased to as much as 41%. Requesting at least two markers out of two or three to be positive certainly reduced the number of 'false-positive' benign tumours, but the sensitivity for malignant tumours was reduced concomitantly to levels where marker determinations would be of little use. The study demonstrated a possible, but limited role for preoperative determinations of the markers. A combination of two or three markers was not superior to single markers. The results indicate that neither of these markers will be of significant value in a screening context.
authors.affiliation: Department of Gynaecology and Obstetrics, Herlev Hospital, Copenhagen, Denmark.
authors.forename: K
authors.initials: K
authors.lastname: Toftager-Larsen
authors.forename: U
authors.initials: U
authors.lastname: Hørding
authors.forename: A
authors.initials: A
authors.lastname: Dreisler
authors.forename: S
authors.initials: S
authors.lastname: Daugaard
authors.forename: B
authors.initials: B
authors.lastname: Lund
authors.forename: J
authors.initials: J
authors.lastname: Bock
authors.forename: F
authors.initials: F
authors.lastname: Lundvall
authors.forename: K
authors.initials: K
authors.lastname: Frederiksen
authors.forename: B
authors.initials: B
authors.lastname: Nørgaard-Pedersen
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood*; D000951:Antigens, Neoplasm / Q000032:analysis*; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis*; D014408:Biomarkers, Tumor; D002277:Carcinoma / Q000175:diagnosis* / Q000601:surgery; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000601:surgery; D010455:Peptides / Q000032:analysis*; D010920:Placenta / Q000201:enzymology*; D019396:Tissue Polypeptide Antigen
chemical_list: D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D010455:Peptides; D019396:Tissue Polypeptide Antigen; D000469:Alkaline Phosphatase