Alpha 1-adrenergic stimulation of low Km GTPase in rat striata is diminished with age.
The effect of norepinephrine and epinephrine on the activity of low Km GTPase was studied in striata from young and old rats. Results showed that the amines stimulated the low Km GTPase activity of both young and old animals in a concentration-dependent manner. There was no differential effect of the amines as a function of age, but the stimulated low Km GTPase activity was significantly lower in the aged tissue.
Villalobos-Molina
R
R
Molecular Physiology and Genetics Section, Gerontology Research Center, NIA, NIH, Baltimore, MD.
Joseph
J A
JA
Roth
G S
GS
D000375:Aging / Q000378:metabolism*; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects* / Q000201:enzymology; D004837:Epinephrine / Q000494:pharmacology*; D020558:GTP Phosphohydrolases / Q000378:metabolism*; D007700:Kinetics; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*
D011942:Receptors, Adrenergic, alpha; D020558:GTP Phosphohydrolases; D009638:Norepinephrine; D004837:Epinephrine