Effects of dauricine and anisodamine on LTs and PAF induced DNA synthesis in bovine anterior cerebral arterial smooth muscle cells.
The effects of leukotrienes (LTs) and platelet activating factor (PAF) on DNA synthesis in bovine anterior cerebral arterial smooth muscle cells were studied. The results showed that LTB4, LTD4 and PAF were all stimulatory to the cells. The maximal rates of stimulation were 32%, 29% and 77%, respectively, for LTB4, LTD4 and PAF at 10(-7) mol/L. Both dauricine and anisodamine at concentrations of 10(-7) to 10(-4) mol/L exhibited strong inhibitory effects on LTs and PAF induced DNA synthesis.
Zeng
G Q
GQ
Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai.
Ju
D W
DW
Sun
D X
DX
Rui
Y C
YC
D000470:Alkaloids; D000818:Animals; D044182:Benzylisoquinolines; D002417:Cattle; D002478:Cells, Cultured; D002536:Cerebral Arteries / Q000166:cytology; D004247:DNA / Q000096:biosynthesis*; D007546:Isoquinolines / Q000494:pharmacology*; D007975:Leukotriene B4 / Q000494:pharmacology; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D010972:Platelet Activating Factor / Q000494:pharmacology; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D013189:SRS-A / Q000494:pharmacology; D012991:Solanaceous Alkaloids / Q000494:pharmacology*; D044005:Tetrahydroisoquinolines; D014665:Vasodilator Agents / Q000494:pharmacology
D000470:Alkaloids; D044182:Benzylisoquinolines; D007546:Isoquinolines; D010972:Platelet Activating Factor; D010975:Platelet Aggregation Inhibitors; D013189:SRS-A; D012991:Solanaceous Alkaloids; D044005:Tetrahydroisoquinolines; D014665:Vasodilator Agents; C003922:anisodamine; D007975:Leukotriene B4; C035934:dauricine; D004247:DNA