title: [The mucin profile in the mucosa of the large intestine in neoplasms].
abstract: Qualitative and quantitative changes in secretion of goblet cells of large bowel mucosa in adenomatous polyps (60), adenocarcinoma (30) and bioptates of adjacent transitional mucosa (30) were studied. As neoplasia progressed, mucin profile appeared to follow a certain pattern: it reached its peak in moderate dysplasia in polyps containing predominantly sulphomucins; subsequently both sulphomucin and sialomucin levels decreased. Adenocarcinomas showed a sharp drop in glycoprotein level, and an insignificant build-up of sialomucins was registered in some cases only. Enhanced abnormal secretion was observed in mucinous carcinoma and adenocarcinoma characterized by the presence of large mucinous areas. Also, qualitative changes were identified in transitional mucosa adjacent to tumor.
authors.forename: A A
authors.initials: AA
authors.lastname: Bagdasarian
authors.forename: E V
authors.initials: EV
authors.lastname: Manukian
authors.forename: L A
authors.initials: LA
authors.lastname: Oganesian
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry* / Q000378:metabolism / Q000473:pathology; D000236:Adenoma / Q000737:chemistry* / Q000378:metabolism / Q000473:pathology; D001706:Biopsy; D006651:Histocytochemistry; D006801:Humans; D007413:Intestinal Mucosa / Q000737:chemistry* / Q000378:metabolism / Q000473:pathology; D007414:Intestinal Neoplasms / Q000737:chemistry* / Q000378:metabolism / Q000473:pathology; D007420:Intestine, Large / Q000737:chemistry* / Q000378:metabolism / Q000473:pathology; D009077:Mucins / Q000032:analysis* / Q000378:metabolism; D009093:Mucus / Q000737:chemistry / Q000378:metabolism
chemical_list: D009077:Mucins
vernacular_title: Profil' mutsinov v slizistoĭ obolochke tolstoĭ kishki pri neoplazii.