[Ligands possessing affinity to specific DNA base pair sequences. IX. Synthesis of netropsin and distamycin A analogs having sarcolysin residues or a platinum(II) atom].
In search for compounds capable of forming covalent bonds with DNA AT-pair clusters, distamycin A and netropsin analogues containing DL-sarcolysin or platinum (II) atom at the N-terminus of the molecule were synthesized, as well as bis-netropsin and bis-distamycin in which two netropsin- or distamycin-like fragments are bound via a cis-diammineplatinum (II) residue. It is shown that these substances can be used for the DNA selective cleavage.
Grokhovskiĭ
S L
SL
Gottikh
B P
BP
Zhuze
A L
AL
D001482:Base Composition; D002945:Cisplatin / Q000737:chemistry; D004247:DNA / Q000378:metabolism*; D004214:Distamycins / Q000138:chemical synthesis*; D008024:Ligands; D008558:Melphalan / Q000737:chemistry*; D009429:Netropsin / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D010984:Platinum / Q000737:chemistry*
D004214:Distamycins; D008024:Ligands; D010984:Platinum; D009429:Netropsin; C030000:stallimycin; D004247:DNA; D002945:Cisplatin; D008558:Melphalan
Ligandy, obladaiushchie srodstvom k opredelennym posledovatel'nostiam par osnovaniĭ DNK. IX. Sintez analogov netropsina i distamitsina A, soderzhashchikh ostatok sarkolizina ili atom platiny(II).