title: MR imaging of cerebral perfusion by phase-angle reconstruction of bolus paramagnetic-induced frequency shifts.
abstract: Phase-angle images are acquired dynamically during bolus paramagnetic contrast injection and demonstrate a phase-enhancement effect in perfused cerebral tissues. Signal-to-noise is comparable to that of susceptibility-based signal loss (delta R*) images. Assuming that phase shift is proportional to the tissue paramagnetic agent concentration, as supported by experimental data, the integrated area of the phase time response curves estimated the relative gray to white matter blood volume as 1.8:1 and was sensitive to acute ischemia. The relation between tissue phase shift and concentration is considered.
authors.affiliation: Department of Radiology and Radiological Science, Johns Hopkins Hospital, Baltimore, Maryland 21287.
authors.forename: T E
authors.initials: TE
authors.lastname: Conturo
authors.forename: P B
authors.initials: PB
authors.lastname: Barker
authors.forename: V P
authors.initials: VP
authors.lastname: Mathews
authors.forename: L H
authors.initials: LH
authors.lastname: Monsein
authors.forename: R N
authors.initials: RN
authors.lastname: Bryan
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology* / Q000098:blood supply; D002545:Brain Ischemia / Q000175:diagnosis; D002196:Capillaries / Q000473:pathology; D002560:Cerebrovascular Circulation; D003287:Contrast Media / Q000008:administration & dosage; D004419:Dysprosium / Q000008:administration & dosage; D004578:Electron Spin Resonance Spectroscopy; D005682:Gadolinium / Q000008:administration & dosage; D019786:Gadolinium DTPA; D007089:Image Enhancement / Q000379:methods; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008833:Microcirculation; D008954:Models, Biological; D008956:Models, Chemical; D008961:Models, Structural; D009942:Organometallic Compounds / Q000008:administration & dosage; D010215:Papio; D004369:Pentetic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives; D011699:Putamen / Q000098:blood supply / Q000473:pathology
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C061756:sprodiamide; D004419:Dysprosium; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA