G proteins in cellular control.
In the past year, cDNA cloning has revealed substantial diversity in G protein alpha, beta and gamma subunits. The number of cellular functions recognized to be controlled by G proteins is also increasing. Most G proteins are associated with the cytoplasmic surface of the plasma membrane, and molecular mechanisms for membrane association of certain G protein subunits have been defined recently. Mutations in G protein subunits, both artificially induced and naturally occurring, have provided important insights into G protein structure and function.
Spiegel
A M
AM
National Institutes of Health, Bethesda, Maryland.
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000235:genetics / Q000502:physiology*; D014644:Genetic Variation; D006801:Humans; D009154:Mutation; D011956:Receptors, Cell Surface / Q000378:metabolism
D011956:Receptors, Cell Surface; D019204:GTP-Binding Proteins