title: Theophylline inhibits late asthmatic reactions induced by toluene diisocyanate in sensitised subjects.
abstract: Toluene diisocyanate (TDI)-induced asthma is a frequent occupational airway disease. To determine whether a calibrated dosage of oral slow-release theophylline inhibits asthmatic reactions and the associated increase of airway responsiveness to methacholine induced by TDI, we examined six asthmatic subjects who developed a late or a dual asthmatic reaction after TDI inhalation challenge. We administered oral slow-release theophylline or placebo to each subject for 7 days according to a double-blind, randomized, cross-over study design. When the subjects received a placebo, TDI caused a late or a dual asthmatic reaction. When the subjects received theophylline. TDI caused significantly reduced late asthmatic reactions. Mean serum theophylline concentrations were within the therapeutic range. Theophylline neither modified the baseline airway responsiveness to methacholine, nor the increase of airway responsiveness to methacholine induced by TDI. These results suggest that slow-release theophylline may improve TDI-induced late asthmatic reactions, but it does not change the baseline airway responsiveness to methacholine and the increase of airway responsiveness to methacholine induced by TDI.
authors.affiliation: Institute of Infectious and Respiratory Diseases, University of Ferrara, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Crescioli
authors.forename: N
authors.initials: N
authors.lastname: De Marzo
authors.forename: P
authors.initials: P
authors.lastname: Boschetto
authors.forename: A
authors.initials: A
authors.lastname: Spinazzi
authors.forename: M
authors.initials: M
authors.lastname: Plebani
authors.forename: C E
authors.initials: CE
authors.lastname: Mapp
authors.forename: L M
authors.initials: LM
authors.lastname: Fabbri
authors.forename: A
authors.initials: A
authors.lastname: Ciaccia
mesh_terms: D000280:Administration, Inhalation; D000284:Administration, Oral; D000704:Analysis of Variance; D001249:Asthma / Q000139:chemically induced / Q000188:drug therapy*; D001985:Bronchial Provocation Tests; D004311:Double-Blind Method; D006801:Humans; D010919:Placebos; D013806:Theophylline / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D014051:Toluene 2,4-Diisocyanate / Q000037:antagonists & inhibitors*
chemical_list: D010919:Placebos; D014051:Toluene 2,4-Diisocyanate; D013806:Theophylline