title: TGF beta signals through a heteromeric protein kinase receptor complex.
abstract: Transforming growth factor beta (TGF beta) binds with high affinity to the type II receptor, a transmembrane protein with a cytoplasmic serine/threonine kinase domain. We show that the type II receptor requires both its kinase activity and association with another TGF beta-binding protein, the type I receptor, to signal growth inhibition and early gene responses. Receptors I and II associate as interdependent components of a heteromeric complex: receptor I requires receptor II to bind TGF beta, and receptor II requires receptor I to signal. This mode of operation points to fundamental differences between this receptor and the protein-tyrosine kinase cytokine receptors.
authors.affiliation: Cell Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
authors.forename: J L
authors.initials: JL
authors.lastname: Wrana
authors.forename: L
authors.initials: L
authors.lastname: Attisano
authors.forename: J
authors.initials: J
authors.lastname: Cárcamo
authors.forename: A
authors.initials: A
authors.lastname: Zentella
authors.forename: J
authors.initials: J
authors.lastname: Doody
authors.forename: M
authors.initials: M
authors.lastname: Laiho
authors.forename: X F
authors.initials: XF
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Massagué
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001667:Binding, Competitive; D002460:Cell Line; D008907:Mink; D008954:Models, Biological; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes; D011494:Protein Kinases / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012694:Serine; D015398:Signal Transduction; D013912:Threonine; D016212:Transforming Growth Factor beta / Q000737:chemistry / Q000378:metabolism*
chemical_list: D009097:Multienzyme Complexes; D011956:Receptors, Cell Surface; D016212:Transforming Growth Factor beta; D013912:Threonine; D012694:Serine; D011494:Protein Kinases