title: [Condylomata acuminata in children--detection of HPV 6/11 and 2. Local therapy with interferon-beta hydrogel].
abstract: Four cases of genital warts in children (girls) are reported. HPV 6/11-DNA was identified in two cases, and HPV 2-DNA in one. In one case no virus identification was possible. The clinical features of the HPV 2-induced genital warts showed the typical morphology of condylomata acuminata. The mode of transmission of the virus, in absence of sexual contact, could not be explained. The HPV 2-associated genital warts might have been transmitted by autoinoculation from warts on the hands. Topical treatment with IFN-beta-hydrogel was applied over 8 weeks, either as single-agent therapy (1 case) or as adjuvant therapy after removal of the condylomata (3 cases). No remission was seen with the single-agent therapy. In one case the genital warts reappeared after adjuvant therapy, but in the other two cases no recurrence was seen.
authors.affiliation: Universitäts-Hautklinik Tübingen.
authors.forename: G
authors.initials: G
authors.lastname: Fierlbeck
authors.forename: G
authors.initials: G
authors.lastname: Rassner
authors.forename: H
authors.initials: H
authors.lastname: Pfister
mesh_terms: D000287:Administration, Topical; D001005:Anus Neoplasms / Q000473:pathology* / Q000628:therapy; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003218:Condylomata Acuminata / Q000473:pathology* / Q000628:therapy; D015344:DNA Probes, HPV; D005260:Female; D006801:Humans; D016899:Interferon-beta / Q000008:administration & dosage*; D027383:Papillomaviridae / Q000145:classification*; D012867:Skin / Q000473:pathology; D014412:Tumor Virus Infections / Q000473:pathology* / Q000628:therapy
chemical_list: D015344:DNA Probes, HPV; D016899:Interferon-beta
vernacular_title: Condylomata acuminata bei Kindern--Nachweis von HPV 6/11 und 2. Lokaltherapie mit Interferon-beta-Hydrogel.