Antiviral phloroglucinols from New Zealand Kunzea species.
Four acyl-phloroglucinol derivatives showing antiviral activity have been isolated from Kunzea sinclairii and Kunzea ericoides (Myrtaceae) from New Zealand. The structures of these compounds were deduced from analysis of spectral data. Two of these compounds, 1 and 2, are the isomers of isobutyryl methoxyresorcinol. The two new compounds, 3 and 4, were isolated as a mixture and determined to be 4-cyclohexene-1,3-dioxo-5-hydroxy-2,2,6,6-tetramethyl-4- (1-[2,6-dihydroxy-4- methoxy-3-(3-methyl-1-oxobutyl)phenyl]-3-methylbutyl) and its 2-methyl-1-oxopropyl analogue, respectively.
Bloor
S J
SJ
DSIR Chemistry, Petone, New Zealand.
D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010696:Phloroglucinol / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology*; D018139:Simplexvirus / Q000187:drug effects
D000998:Antiviral Agents; D010696:Phloroglucinol