Surveillance for CMV infection in orthotopic liver transplant recipients.
Infection with cytomegalovirus is a major cause of morbidity and mortality following orthotopic liver transplantation. In order that preventive strategies may be devised, a detailed assessment of risk factors for infection and disease is required. We have prospectively assessed 46 orthotopic liver transplant recipients for CMV excretion from multiple sites in order to determine incidence of, and risk factors for, CMV infection and disease. Risk factors for posttransplant CMV infection were donor CMV seropositivity, an increased volume of peritransplant whole-blood transfusion and an increased dose of extra steroid therapy to treat rejection episodes. These findings implicate, respectively, transfer of virus with donor organ, transfer of virus with blood transfusion, and stimulation of reactivation of latent virus in recipients through augmented immunosuppression. The possible ways of preventing or ameliorating these effects are discussed.
Pillay
D
D
Division of Communicable Diseases, Royal Free Hospital and School of Medicine, London, England.
Charman
H
H
Burroughs
A K
AK
Smith
M
M
Rolles
K
K
Griffiths
P D
PD
D000328:Adult; D001706:Biopsy; D001769:Blood / Q000382:microbiology; D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000254:growth & development / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects* / Q000473:pathology; D008875:Middle Aged; D012307:Risk Factors; D014775:Virus Activation