Transition from interleukin 1 beta (IL-1 beta) to IL-1 alpha production during maturation of inflammatory macrophages in vivo.
In situ production of interleukin 1 alpha (IL-1 alpha) and IL-1 beta was investigated in Peyer's patches (PP) of mice undergoing an acute bacterial infection with Yersinia enterocolitica O8. Synthesis of IL-1 beta, as determined by immunohistochemistry, was found primarily in monocytes migrating into the inflamed PP. In comparison, synthesis of IL-1 alpha was temporarily delayed by at least 24 h and was only found in mature macrophages, which did not produce detectable levels of IL-1 beta. This indicates a transition from IL-1 beta to IL-1 alpha production during maturation of monocytes into inflammatory macrophages, and further emphasizes a dichotomy between IL-1 alpha and IL-1 beta.
Beuscher
H U
HU
Institute of Clinical Microbiology, University of Erlangen-Nürnberg, Germany.
Rausch
U P
UP
Otterness
I G
IG
Röllinghoff
M
M
D000818:Animals; D005455:Fluorescent Antibody Technique; D007124:Immunoenzyme Techniques; D007249:Inflammation; D007375:Interleukin-1 / Q000096:biosynthesis*; D008264:Macrophages / Q000473:pathology / Q000502:physiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009195:Peroxidase / Q000032:analysis; D015009:Yersinia Infections / Q000473:pathology / Q000503:physiopathology*
D007375:Interleukin-1; D009195:Peroxidase