[The effect of tocolytic drugs on oxytocin-induced uterine contractility in vitro].
The results obtained demonstrate that the blockers of calcium channels effectively inhibit uterine contractions induced by oxytocin. Its effects depends on the doses administered and is comparable to those of ritodrine and of magnesium sulphate. A channel of potassium, dependent on calcium was also identified and this channel was activated by oxytocin.
Muñoz
H
H
Departamento de Obstetricia y Ginecología, Hospital Clínico J. J. Aguirre, Chile.
Marusic
E
E
D000704:Analysis of Variance; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D066298:In Vitro Techniques; D009215:Myometrium / Q000187:drug effects; D010121:Oxytocin / Q000494:pharmacology*; D015221:Potassium Channels / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D015149:Tocolytic Agents / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects*
D002121:Calcium Channel Blockers; D015221:Potassium Channels; D015149:Tocolytic Agents; D010121:Oxytocin
Efecto de fármacos tocolíticos sobre la contractilidad uterina inducida por oxitocina in vitro.