[The mechanism of the effect of reserpine on endocrine system function].
The experiments in rabbits and guinea-pigs showed that the use of reserpine, 0.1 and 0.25 mg/kg body weight a day, led to a 2-2.8-fold increase in thyroid hormones and 25-45% enhancement in cortisol in the blood. At the same time cAMP concentrations increased by 87% and almost by 5 times in the thyroid and adrenals, respectively. The pancreas exhibited a 5-fold increase in cAMP, 2.5- and 2.3-fold decrease in insulin in rabbit peripheral blood and in the activity of pancreatic aldolase and dehydrogenases, respectively. Blood levels of glucose reduced by 15-17%.
Ablaev
N R
NR
Pichkhadze
G M
GM
D000305:Adrenal Cortex Hormones / Q000097:blood; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D004702:Endocrine Glands / Q000187:drug effects* / Q000378:metabolism; D006168:Guinea Pigs; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D011817:Rabbits; D012110:Reserpine / Q000494:pharmacology*; D013963:Thyroid Hormones / Q000097:blood
D000305:Adrenal Cortex Hormones; D010726:Phosphodiesterase Inhibitors; D013963:Thyroid Hormones; D012110:Reserpine; D000242:Cyclic AMP; D006152:Cyclic GMP
K mekhanizmu vliianiia rezerpina na sostoianie éndokrinnoĭ sistemy.