[Molecular biology of membrane transport proteins of renal tubules].
Molecular biology techniques are now opening a new era in renal epithelial transport physiology and biology. Two things emerge as a result of molecular biology studies. 1) Transporters are usually composed of several isoforms. Expressions of each isoforms are different in timing and localization, thus, they play different physiological roles. 2) Comparison of sequence homology allows speculation of superfamily and root of transporter gene. Based on this idea it is not surprising that one transporter shows three functions; channel, enzyme, and carrier. In this review current understanding of kidney transport protein by molecular biology is summarized. Topics are: GLUT, Na/glucose cotransporter, Na/H exchanger, Cl/HCO3 exchanger, amino acids transporter, water channel, CFTR, MDR.
Sasaki
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Second Department of Internal Medicine, Tokyo Medical and Dental University.
D026905:Amino Acid Transport Systems; D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002352:Carrier Proteins / Q000378:metabolism* / Q000502:physiology; D027963:Chloride-Bicarbonate Antiporters; D006801:Humans; D007684:Kidney Tubules / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D009004:Monosaccharide Transport Proteins / Q000378:metabolism / Q000502:physiology; D017923:Sodium-Hydrogen Exchangers
D026905:Amino Acid Transport Systems; D002352:Carrier Proteins; D027963:Chloride-Bicarbonate Antiporters; D008565:Membrane Proteins; D009004:Monosaccharide Transport Proteins; D017923:Sodium-Hydrogen Exchangers