Impact of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept.
A scientific evaluation was made of the mechanisms of action of polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls. Distinction is made between the aryl-hydrocarbon (Ah) receptor-mediated and non-Ah receptor-mediated toxic responses. Special attention is paid to the applicability of the toxic equivalency factor (TEF) concept.
Ahlborg
U G
UG
Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
Brouwer
A
A
Fingerhut
M A
MA
Jacobson
J L
JL
Jacobson
S W
SW
Kennedy
S W
SW
Kettrup
A A
AA
Koeman
J H
JH
Poiger
H
H
Rappe
C
C
D000818:Animals; D001572:Benzofurans / Q000009:adverse effects* / Q000378:metabolism / Q000633:toxicity; D004435:Eating; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000009:adverse effects* / Q000378:metabolism / Q000633:toxicity; D006801:Humans; D016273:Occupational Exposure; D011078:Polychlorinated Biphenyls / Q000009:adverse effects* / Q000378:metabolism / Q000633:toxicity; D000072317:Polychlorinated Dibenzodioxins / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000378:metabolism / Q000633:toxicity; D011108:Polymers / Q000009:adverse effects* / Q000378:metabolism / Q000633:toxicity; D018336:Receptors, Aryl Hydrocarbon; D011955:Receptors, Drug / Q000378:metabolism; D012308:Risk Management; D014018:Tissue Distribution
D001572:Benzofurans; D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins; D011108:Polymers; D018336:Receptors, Aryl Hydrocarbon; D011955:Receptors, Drug; C016068:polychlorodibenzofuran; D011078:Polychlorinated Biphenyls