Effect of dietary excess-histidine on fructose 1,6-bisphosphatase and 6-phosphofructokinase activities, and activation of fructose 1,6-bisphosphatase by basic amino acids in rat liver.
1. Dietary excess histidine caused an increase in the total activity of fructose 1,6-bisphosphatase, and a decrease in 6-phosphofructokinase in the liver. 2. The hepatic concentrations of free histidine and lysine were higher in rats fed a histidine-excess diet. 3. The addition of histidine, lysine or arginine to the assay mixture for fructose 1,6-bisphosphatase resulted in a significant increase in its activity. The 6-phosphofructokinase activity in the liver was not enhanced by the addition of histidine to the assay mixture.
Aoyama
Y
Y
Department of Agricultural Chemistry, School of Agriculture, Nagoya University, Japan.
Tsuda
T
T
Hitomi-Ohmura
E
E
Yoshida
A
A
D000596:Amino Acids / Q000502:physiology*; D000818:Animals; D001120:Arginine / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D004032:Diet; D004789:Enzyme Activation; D006597:Fructose-Bisphosphatase / Q000378:metabolism*; D006003:Glycogen / Q000378:metabolism; D006639:Histidine / Q000008:administration & dosage / Q000502:physiology*; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D008239:Lysine / Q000502:physiology; D008297:Male; D009929:Organ Size; D010732:Phosphofructokinase-1 / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D001786:Blood Glucose; D006639:Histidine; D006003:Glycogen; D001120:Arginine; D002784:Cholesterol; D010732:Phosphofructokinase-1; D006597:Fructose-Bisphosphatase; D008239:Lysine