Evidence suggesting an evolutionary relationship between transposable elements and immune system recombination sequences.
Sequence similarity between the termini of invertebrate Tcl-like transposable sequences and the signal sequences of the vertebrate immunoglobulin somatic recombination pathway is described. These similarities suggest that the Tcl transposition pathway may share common sequence-specific binding factors with the immunoglobulin somatic recombination pathway.
Dreyfus
D H
DH
Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461.
D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D004251:DNA Transposable Elements; D005803:Genes, Immunoglobulin; D005812:Genes, Switch; D051379:Mice; D008969:Molecular Sequence Data; D011995:Recombination, Genetic; D012045:Regulatory Sequences, Nucleic Acid; D012689:Sequence Homology, Nucleic Acid
D004251:DNA Transposable Elements