[Effects of prostaglandin E2 on growth and function of osteoblasts in human cell culture in vitro].
The effects of prostaglandin E 2 (PGE2) on the differentiation and proliferation of osteoblasts (human fetal bone-cells) cultured in serum-free medium were investigated by assays of alkaline phosphatase (ALP) activity, intracellular cyclic AMP level and collagen synthesis in the cells. The results suggested that PGE2 in physiologic concentration stimulated the differentiation of osteoblasts in vitro, and might be involved in bone formation in vivo.
Peng
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Tianjin of Endocrinology Institute.
D000469:Alkaline Phosphatase / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003094:Collagen / Q000096:biosynthesis; D000242:Cyclic AMP / Q000378:metabolism; D015232:Dinoprostone / Q000494:pharmacology*; D005333:Fetus; D006801:Humans; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects* / Q000502:physiology
D003094:Collagen; D000242:Cyclic AMP; D000469:Alkaline Phosphatase; D015232:Dinoprostone