title: Digitalis-like compounds in animal tissues.
abstract: The Na+, K+ activated adenosine triphosphatase is present in the membrane of eukaryotic cells and represents a major pathway for Na+ and K+ transport across the plasma membrane. Cardiac glycosides such as ouabain or digoxin suppress this enzyme activity by binding to a specific receptor on the membrane. Studies conducted in this and other laboratories have proven the existence of digitalis-like compounds in animal tissues which may serve as in vivo regulators of the Na+, K(+)-pump activity. This review summarizes the attempts to identify these compounds from animal tissues and examines the potential physiological role of some of the identified compounds.
authors.affiliation: Department of Physiology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Lichtstein
authors.forename: S
authors.initials: S
authors.lastname: Samuelov
authors.forename: I
authors.initials: I
authors.lastname: Gati
authors.forename: W J
authors.initials: WJ
authors.lastname: Wechter
mesh_terms: D000818:Animals; D004071:Digitalis Glycosides / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
chemical_list: D004071:Digitalis Glycosides; D000254:Sodium-Potassium-Exchanging ATPase