Malignant placental site trophoblastic tumor associated with placental abruption, fetal distress, and elevated CA-125.
The second pregnancy of 27-year-old woman, gravida 2, para 2 was complicated by a low alpha-fetoprotein and symptoms of chronic placental abruption. She delivered by cesarean section at 35 weeks for fetal distress at which time a biopsy of the uterus revealed a placental site trophoblastic tumor (PSTT). She rapidly developed intraabdominal spread of the neoplasm which did not respond to chemotherapy and she died 10 weeks later. Her CA-125 was elevated to 5360 mu/ml and this decreased after hysterectomy. This patient is reported to highlight a very malignant course of PSTT that was associated with a live-born male infant.
Hopkins
M P
MP
Department of Obstetrics & Gynecology, University of Michigan Medical Center, Ann Arbor.
Drescher
C W
CW
McQuillan
A
A
Keyser
J
J
Schmidt
R
R
D000037:Abruptio Placentae / Q000209:etiology*; D000328:Adult; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D005260:Female; D005316:Fetal Distress / Q000209:etiology*; D006801:Humans; D008297:Male; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000150:complications* / Q000276:immunology / Q000473:pathology; D014594:Uterine Neoplasms / Q000150:complications* / Q000276:immunology / Q000473:pathology
D015295:Antigens, Tumor-Associated, Carbohydrate