title: Paget's disease of the vulva: advantages of demolitive surgery.
abstract: Four patients with vulvar Paget's disease were analysed retrospectively. In all cases the clinical manifestation was typical, with pruritus and visible lesion. None of the cases had a palpable cutaneous or subcutaneous mass but at the histologic exam a minimally invasive Paget's disease was detected. Treatment consisted of total vulvectomy and subsequent new reconstructive time; only one patient with clinically localized disease was treated with simple vulvectomy. Postoperative complications were minimal, thanks to the reconstructive time that assured a rapid recovery of the surgical injury and reconstruction of the urethral and vaginal meatuses. In all cases we obtained the complete removal of the lesion (negativity of resection margins), except in one case that was also the only one to have a recurrence after 40 months. The patients have been followed for an average of 58 months. Considering the results, we suggest demolitive surgery with subsequent reconstructive time in the treatment of vulvar Paget's disease.
authors.affiliation: Department of Obstetrics and Gynecology, Ancona University, Italy.
authors.forename: G G
authors.initials: GG
authors.lastname: Garzetti
authors.forename: A
authors.initials: A
authors.lastname: Bertani
authors.forename: A L
authors.initials: AL
authors.lastname: Tranquilli
authors.forename: M
authors.initials: M
authors.lastname: Tiriduzzi
authors.forename: H
authors.initials: H
authors.lastname: Valensise
authors.forename: C
authors.initials: C
authors.lastname: Romanini
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008875:Middle Aged; D010145:Paget Disease, Extramammary / Q000601:surgery*; D012189:Retrospective Studies; D014846:Vulvar Neoplasms / Q000601:surgery*