Hemorrhagic cystitis with herpes simplex virus type 2 in the bladder mucosa.
A 67-year-old woman who had underlying rheumatoid arthritis and diabetes mellitus had an 8-year history of recurrent hemorrhagic cystitis. During her most recent episode of cystitis, a specimen of urine yielded herpes simplex virus type 2 in culture. A biopsy of the bladder mucosa revealed intranuclear inclusions in multinucleated and mononuclear giant cells that were positive for herpes simplex virus type 2 by immunoperoxidase staining. She had no evidence of infection with herpes simplex virus outside her bladder.
Nguyen
M L
ML
Department of Medicine, Montefiore University Hospital, Pittsburgh, Pennsylvania 15213.
Borochovitz
D
D
Thomas
G
G
McClure
T
T
Ruben
F L
FL
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications; D003556:Cystitis / Q000150:complications / Q000382:microbiology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D005260:Female; D006470:Hemorrhage / Q000150:complications / Q000382:microbiology*; D006561:Herpes Simplex / Q000150:complications / Q000382:microbiology*; D006801:Humans; D009092:Mucous Membrane / Q000382:microbiology / Q000473:pathology; D012008:Recurrence; D018139:Simplexvirus / Q000302:isolation & purification*; D001743:Urinary Bladder / Q000382:microbiology* / Q000473:pathology