[The effect of an experimental autoimmune process on the structural-functional changes in the spleen of progeny].
During early postnatal ontogenesis structural-functional changes of the spleen have been studied in the offspring of the females, having an experimental chronic autoimmune process with a predominant liver lesion. An increase of the spleen index, amount of IgM-producing cells and karyocytes in the spleen has been noted in the offspring of the given group of animals during all periods of the investigation, while in B-zones certain changes have been revealed demonstrating an enhancement of proliferative and differentiation processes. As a whole, these results are signs of the humoral immunogenesis strain. Simultaneously, in the spleen of the animals a decrease in the number of cells, forming rosellas with sheep erythrocytes and inhibition of their temperature resistivity have been noted. Besides, in the periarterial zones of their spleen, changes demonstrating certain inhibition of proliferation have been revealed; this can be considered as a depression of reactions of the cellular immunity.
Briukhin
G V
GV
Mikhaĭlova
G I
GI
D000818:Animals; D000831:Animals, Newborn; D000917:Antibody Formation; D001327:Autoimmune Diseases / Q000276:immunology / Q000503:physiopathology*; D002908:Chronic Disease; D004195:Disease Models, Animal; D005260:Female; D007111:Immunity, Cellular; D007114:Immunization / Q000379:methods; D008107:Liver Diseases / Q000276:immunology / Q000503:physiopathology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000276:immunology / Q000503:physiopathology*
Vliianie éksperimental'nogo autoimmunnogo protsessa na strukturno-funktsional'nye izmeneniia selezenki u potomstva.