title: Rhabdomyosarcomas developing in association with mediastinal germ cell tumours.
abstract: Two mediastinal rhabdomyosarcomas that arose in association with germ cell tumours are reported. One presented as a small component of a mixed germ cell tumour with yolk sac and immature teratomatous elements. The other appeared as a large mass 4 months after diagnosis of a yolk sac carcinoma that had been treated with chemotherapy. The first patient was alive and free of disease 7 years later, whereas the second died of tumour 3 months post-operatively. The proportion of rhabdomyosarcoma within the germ cell tumours appears to have influenced the prognosis of these patients. This observation emphasizes the necessity of performing a thorough search for sarcomatous elements and quantifying their relative proportion in germ cell tumours of the mediastinum.
authors.affiliation: Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Caballero
authors.forename: S
authors.initials: S
authors.lastname: Gomez
authors.forename: X
authors.initials: X
authors.lastname: Matias-Guiu
authors.forename: J
authors.initials: J
authors.lastname: Prat
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000473:pathology*; D008875:Middle Aged; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology*; D016609:Neoplasms, Second Primary; D012208:Rhabdomyosarcoma / Q000473:pathology*