Effects of midazolam on T-cell immunosuppressive response to surgical stress in mice.
Mice submitted to surgical stress induced by laparotomy and treated with chronic midazolam (1 mg/kg) showed a reduction in stress-induced suppression of thymus and spleen cellularity and in peripheral lymphocyte population. The blastogenic response of spleen lymphoid cells was also assessed and midazolam was found to partially attenuate the suppressive effect of surgery.
Freire-Garabal
M
M
Department of Pharmacology, Faculty of Medicine, University of Santiago de Compostela, Spain.
Belmonte
A
A
Balboa
J L
JL
Núñez
M J
MJ
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D007165:Immunosuppression Therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D008874:Midazolam / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D013154:Spleen / Q000166:cytology; D013312:Stress, Physiological / Q000276:immunology*; D013514:Surgical Procedures, Operative; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology
D003208:Concanavalin A; D000324:Adrenocorticotropic Hormone; D008874:Midazolam