[The sensitivity of yeasts from the Candida genus isolated from cancer patients to polyene antifungals].
Candida strains susceptibility from cancer patients were compared with Candida strains susceptibility from patients, without cancer by MIC (minimal inhibitory concentration) and MFC (minimal fungicidal concentration) to Amphotericin B and Nystatin. Broth dilution method and agar dilution method were the procedure employed. The authors find no significant differences between the studied groups. The problem of Candida resistance to polyene antifungals is discussed.
Alves
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Laboratório de Análises Clínicas, Hospital Universitário, Universidade Federal de Santa Maria, RS, Brasil.
Cury
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D000666:Amphotericin B / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000935:Antifungal Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000302:isolation & purification; D016009:Chi-Square Distribution; D004305:Dose-Response Relationship, Drug; D004352:Drug Resistance, Microbial; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods / Q000706:statistics & numerical data; D009369:Neoplasms / Q000188:drug therapy / Q000382:microbiology*; D009761:Nystatin / Q000037:antagonists & inhibitors / Q000494:pharmacology; D011090:Polyenes / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D000935:Antifungal Agents; D011090:Polyenes; D009761:Nystatin; D000666:Amphotericin B
Sensibilidade de leveduras do gênero Candida, isoladas de pacientes com câncer, a antifúngicos poliênicos.