Slow release of anticancer drugs from porous calcium hydroxyapatite ceramic.
We have developed a new delivery system for sustained release of an anticancer drug (cis-platinum) by enclosure into blocks of porous calcium hydroxyapatite ceramic. The slow release of this drug from this system was confirmed in in vitro experiments. When this system was implanted into normal back muscle, or the tibia, sustained release of cis-platinum was observed during a 12-week period after implantation. The diffusion rate of cis-platinum into blood and other organs (liver, kidney, brain) was less than 10% of that at the implanted site. This delivery system placed into experimental tumors of mice also showed a uniform release of anticancer drug for more than 3 months. Inhibition of tumor growth was more marked after local implantation of this system than after intraperitoneal administration of cis-platinum. These results indicate that this new approach to a drug delivery system may well have an important role in cancer chemotherapy. In bone tumors it is attractive because the mechanical strength of calcium hydroxyapatite ceramic permits partial surgical excision and replacement of the bone defect at the same time.
Uchida
A
A
Department of Orthopaedic Surgery, Osaka University Medical School, Japan.
Shinto
Y
Y
Araki
N
N
Ono
K
K
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy; D002516:Ceramics / Q000737:chemistry*; D002945:Cisplatin / Q000378:metabolism; D003692:Delayed-Action Preparations / Q000008:administration & dosage*; D004343:Drug Implants; D017886:Durapatite; D006882:Hydroxyapatites / Q000032:analysis / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D051379:Mice; D008809:Mice, Inbred C3H; D012516:Osteosarcoma / Q000188:drug therapy; D051381:Rats; D011919:Rats, Inbred Strains
D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D004343:Drug Implants; D006882:Hydroxyapatites; D017886:Durapatite; D002945:Cisplatin