Protection of bone marrow of Swiss albino mouse against whole body gamma irradiation by WR-2721.
Preinjected with a radioprotective drug, WR-2721, the Swiss albino mice were whole body irradiated with 5 Gy of 60Co gamma rays. The animals were sacrificed at different intervals and bone marrow films were prepared for differential counting of lymphocytes, pronormoblasts and normoblasts and granulocytes. The results indicated significant protection of the bone marrow cells by the drug against radiation induced damage. It is therefore concluded that WR-2721 protects all types of cells including as sensitive ones as lymphocytes, pronormoblasts and normoblasts.
Naruka
K
K
Department of Zoology, University of Rajasthan, Jaipur, India.
Bhartiya
H C
HC
D004999:Amifostine / Q000494:pharmacology*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000528:radiation effects; D005720:Gamma Rays; D008297:Male; D051379:Mice
D004999:Amifostine