title: Conditioned place preference induced by Ro 16-6028, a benzodiazepine receptor partial agonist.
abstract: A place conditioning situation was used to assess the putative affective properties of benzodiazepine receptor ligands in the rat. The benzodiazepine receptor partial agonist Ro 16-6028 induced a conditioned place preference, suggesting that this compound has rewarding properties. The benzodiazepine receptor antagonist Ro 15-1788 induced neither place preference nor aversion, but prevented the place preference induced by Ro 16-6028, suggesting that the rewarding effects of Ro 16-6028 are due to its action on the benzodiazepine receptor. The benzodiazepine receptor full agonist diazepam did not induce a conditioned place preference in our hands, in contrast with previous studies. The sensitivity of place conditioning with benzodiazepine ligands to situational factors, such as the existence of a preconditioning preference, is discussed.
authors.affiliation: Laboratoire de Neurophysiologie et Biologie des Comportements, Centre de Neurochimie du C.N.R.S., Strasbourg, France.
authors.forename: G
authors.initials: G
authors.lastname: Di Scala
authors.forename: P
authors.initials: P
authors.lastname: Oberling
authors.forename: B
authors.initials: B
authors.lastname: Rocha
authors.forename: G
authors.initials: G
authors.lastname: Sandner
mesh_terms: D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects*
chemical_list: D001570:Benzodiazepinones; D011963:Receptors, GABA-A; C054626:bretazenil