Is the thymus a target organ in infectious diseases?
The thymus is a central lymphoid organ, in which T cell precursors differentiate and generate most of the so-called T cell repertoire. Along with a variety of acute infectious diseases, we and others determined important changes in both microenvironmental and lymphoid compartments of the organ. For example, one major and common feature observed in acute viral, bacterial and parasitic diseases, is a depletion of cortical thymocytes, mostly those bearing the CD4-CD8 double positive phenotype. This occurs simultaneously to the relative enrichment in medullary CD4 or CD8 single positive cells, expressing high densities of the CD3 complex. Additionally we noticed a variety of changes in the thymic microenvironment (and particularly its epithelial component), comprising abnormal location of thymic epithelial cell subsets as well has a denser Ia-bearing cellular network. Moreover, the extracellular matrix network was altered with an intralobular increase of basement membrane proteins that positively correlated with the degree of thymocyte death. Lastly, anti-thymic cell antibodies were detected in both human and animal models of infectious diseases, and in some of them a phenomenon of molecular mimicry could be evidenced. Taken together, the data reviewed herein clearly show that the thymus should be regarded as a target in infectious diseases.
Savino
W
W
Departamento de Imunologia, Instituto Oswaldo Cruz, Rio de Janeiro, Brasil.
de Moraes
M do C
Mdo C
Barbosa
S D
SD
Da Fonseca
E C
EC
De Almeida
V C
VC
Hontebeyrie-Joscowicz
M
M
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000473:pathology; D000208:Acute Disease; D000818:Animals; D001284:Atrophy; D001323:Autoantibodies / Q000276:immunology; D002454:Cell Differentiation; D014355:Chagas Disease / Q000276:immunology / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005109:Extracellular Matrix / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007239:Infections / Q000276:immunology / Q000473:pathology*; D016176:T-Lymphocyte Subsets / Q000473:pathology; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology*
D001323:Autoantibodies