title: Sub-acute underfeeding but not acute starvation reduces noradrenaline induced thermogenesis in the conscious rat.
abstract: The thermogenic responses to noradrenaline have been studied during food restriction in conscious rats. Acute starvation for 16-18 h reduced the body weight by 3% but not the resting metabolic rate or the increase in metabolic rate induced by noradrenaline, compared to control rats. Sub-acute underfeeding (eight days) with 50% of the control daily intake decreased body weight by 15% and was associated with a significant (P less than 0.05) reduction in resting metabolic rate and a significant (P less than 0.01) suppression of the thermogenic response to noradrenaline. Thus, food restriction reduces the thermogenic responses to noradrenaline, but only after a certain duration of restricted intake.
authors.affiliation: Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham, UK.
authors.forename: A Y
authors.initials: AY
authors.lastname: Siyamak
authors.forename: I A
authors.initials: IA
authors.lastname: Macdonald
mesh_terms: D000208:Acute Disease; D000818:Animals; D001481:Basal Metabolism; D001833:Body Temperature Regulation / Q000187:drug effects*; D004734:Energy Metabolism; D005508:Food Deprivation / Q000502:physiology*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D013217:Starvation / Q000378:metabolism*; D015431:Weight Loss
chemical_list: D009638:Norepinephrine