Reduction of the metastatic potential of a RSV-transformed fibroblastic line (B77-AA6 cells) upon transplantation in essential fatty acid-deficient mice.
Metastatic dissemination has been shown to be influenced by dietary lipids. In particular, diets enriched with linoleic acid have been consistently found to be effective in enhancing the metastatic potential of murine mammary tumors. This study explored whether an essential fatty acid (EFA)-deficient host can affect the capacity of a tumor to metastasize to the lung. Tumors were developed by subcutaneously injecting high metastatic B77-AA6 cells (a subclone isolated from the Balb/c 3T3 cells transformed by the B77 strain of RSV) into syngeneic mice which had been fed either a control or an EFA-deficient diet for 9 weeks. EFA deficiency did not modify the incidence, latency and growth rate of primary tumors developed from B77-AA6 cells, while it markedly reduced their capacity to reproduce lung macro- and micrometastases. These findings demonstrate that physiological levels of EFA are important for a tumor to metastasize in secondary organs.
Calorini
L
L
Institute of General Pathology, University of Florence, Italy.
Ruggieri
S
S
D016475:3T3 Cells; D000818:Animals; D001358:Avian Sarcoma Viruses; D002461:Cell Line, Transformed; D005227:Fatty Acids / Q000378:metabolism; D005228:Fatty Acids, Essential / Q000172:deficiency*; D005260:Female; D008099:Liver / Q000378:metabolism; D008175:Lung Neoplasms / Q000556:secondary*; D051379:Mice; D008807:Mice, Inbred BALB C; D008954:Models, Biological; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured
D005227:Fatty Acids; D005228:Fatty Acids, Essential