[Infection by human herpesvirus type 6 (HHV-6) and renal transplantation].
Human herpes virus type 6 (HHV-6) infection was serologically investigated in renal transplant recipients. Before transplantation, 75.5% of patients was seropositive for HHV-6 and no correlation with age, sex and time on dialysis was found. During the first month after transplantation 66% of patients showed a variation in serological status against HHV-6 (seroconversion or fourfold increase of antibody titer). All patients who seroconverted had received the kidney from a HHV-6 seropositive donor, furthermore, in 11/13 (84.6%) pairs of patients receiving the kidney form the same seropositive donor, both members or had HHV-6 active infection or had no infection. The frequency of HHV-6 active infection in seropositive patients is almost the same in case of seronegative or seropositive donor. Comparing HHV-6 and CMV infections, they resulted independent as CMV infection in these patients occurs in a following period (II-III month). Notwithstanding a higher frequency of kidney rejection in patients with active HHV-6 infection, no significative correlation was found.
Merlino
C
C
Cattedra di Nefro-Urologia, Università degli Studi di Torino.
Sinesi
F
F
Messina
M
M
Giacchino
F
F
Negro Ponzi
A
A
D000328:Adult; D000914:Antibodies, Viral / Q000096:biosynthesis; D002648:Child; D003586:Cytomegalovirus Infections / Q000150:complications / Q000453:epidemiology; D004198:Disease Susceptibility; D005260:Female; D006084:Graft Rejection; D006566:Herpesviridae Infections / Q000150:complications / Q000453:epidemiology* / Q000635:transmission; D015654:Herpesvirus 6, Human / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D016030:Kidney Transplantation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000382:microbiology*; D015995:Prevalence; D006435:Renal Dialysis; D014775:Virus Activation
D000914:Antibodies, Viral; D007166:Immunosuppressive Agents
Infezione da virus erpetico umano di tipo 6 (HHV-6) e trapianto di rene.