title: Cerebral oxygenation state in chemically-induced seizures in the rat--study by near infrared spectrophotometry.
abstract: The hemoglobin oxygenation state and the redox state of Cyt.ox. in the rat brain during and after seizure induced by PTZ were measured by using near-infrared spectrophotometry. PTZ administration caused transient reduction of Cyt.ox. in the brain, which might be a trigger for the increase of CBF during seizure. In postictal phase, although BP remained high, Cyt.ox. was in the certain reduced state, which might be due to A-V shunt. Hypoxic loading during seizure caused more reduction of Cyt.ox. than under non-epileptic conditions, which meant that seizure even under mild hypoxic conditions could cause severe hypoxic brain damage.
authors.affiliation: Biophysics Division, Hokkaido University, Sapporo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hoshi
authors.forename: M
authors.initials: M
authors.lastname: Tamura
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004569:Electroencephalography; D003576:Electron Transport Complex IV / Q000737:chemistry; D005069:Evaluation Studies as Topic; D006454:Hemoglobins / Q000737:chemistry; D008297:Male; D010084:Oxidation-Reduction; D010101:Oxygen Consumption; D010433:Pentylenetetrazole / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D013055:Spectrophotometry, Infrared / Q000379:methods*
chemical_list: D006454:Hemoglobins; D003576:Electron Transport Complex IV; D010433:Pentylenetetrazole