title: Cytokinesis.
abstract: The actomyosin contractile-ring mechanism remains the paradigm for cytokinesis after 20 years of experimental testing. Recent evidence suggests that Ca2+ triggers the contraction and that cell-cycle kinases regulate the timing of cytokinesis. New work is required to identify the signals from the mitotic spindle that specify the position of the furrow.
authors.affiliation: Department of Cell Biology and Anatomy, Johns Hopkins Medical School, Baltimore, Maryland 21205.
authors.forename: L L
authors.initials: LL
authors.lastname: Satterwhite
authors.forename: T D
authors.initials: TD
authors.lastname: Pollard
mesh_terms: D000205:Actomyosin / Q000502:physiology*; D000818:Animals; D002118:Calcium / Q000502:physiology; D002453:Cell Cycle / Q000502:physiology; D002455:Cell Division; D008938:Mitosis / Q000502:physiology*; D009219:Myosin-Light-Chain Kinase / Q000502:physiology; D010744:Phosphoric Monoester Hydrolases; D010766:Phosphorylation; D008941:Spindle Apparatus / Q000502:physiology
chemical_list: D000205:Actomyosin; D009219:Myosin-Light-Chain Kinase; D010744:Phosphoric Monoester Hydrolases; D002118:Calcium