The effect of nedocromil sodium on the isolated rabbit vagus nerve.
Nedocromil sodium depolarized the isolated rabbit vagus nerve. The depolarization was blocked by DIDS (4,4'-diisothiocyanostilbene-2,2'-disulphonic acid) and did not occur when the nerve was bathed in solutions low in chloride. After depolarization the nerve was refractory to nedocromil sodium for an hour. It is suggested that nedocromil sodium can affect a chloride channel.
Jackson
D M
DM
Department of Pharmacology, Fisons Research and Development Laboratories, Loughborough, Leicestershire, UK.
Pollard
C E
CE
Roberts
S M
SM
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D018118:Chloride Channels; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D008565:Membrane Proteins / Q000187:drug effects; D017835:Nedocromil; D015363:Quinolones / Q000494:pharmacology*; D011817:Rabbits; D014630:Vagus Nerve / Q000187:drug effects* / Q000502:physiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D018118:Chloride Channels; D008565:Membrane Proteins; D015363:Quinolones; D017835:Nedocromil; D002118:Calcium