Age-related changes in central and peripheral benzodiazepine binding sites.
3H-flunitrazepam binding was studied in membranes from different brain regions and from kidneys and adrenals of young (5-month old) and aged (22-month old) rats. Decreased benzodiazepine receptor density (by 33.7%) was observed only in the cerebellum of aged rats. The number of benzodiazepine receptors was significantly increased in the hypothalamus (by 44.1%). Specific 3H-flunitrazepam binding was also significantly increased in both kidney and adrenal membranes from old rats.
Hadjiivanova
C
C
Department of Experimental Pharmacology, Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
Zamdjieva
S
S
Petkov
V V
VV
D000311:Adrenal Glands / Q000378:metabolism / Q000502:physiology; D000375:Aging / Q000378:metabolism*; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism / Q000502:physiology; D005445:Flunitrazepam / Q000493:pharmacokinetics; D007031:Hypothalamus / Q000378:metabolism / Q000502:physiology; D007668:Kidney / Q000378:metabolism / Q000502:physiology; D007700:Kinetics; D010525:Peripheral Nerves / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology*
D011963:Receptors, GABA-A; D005445:Flunitrazepam