title: Verrucous carcinoma of the penis: importance of human papillomavirus typing for diagnosis and therapeutic decision.
abstract: One case of penile verrucous carcinoma (Buschke-Löwenstein tumor) undergoing anaplastic transformation and containing human papillomavirus type 6 is presented. The viral genome is detected by in situ hybridization using biotin-labeled cDNA probes. The clinical, histological and virologic criteria of verrucous carcinoma are discussed in comparison to giant condyloma and highly differentiated squamous cell carcinoma. The importance of viral typing determination for further diagnostic and therapeutic procedures is emphasized.
authors.affiliation: Department of Pathology, Erasme Hospital, Free University of Brussels, Belgium.
authors.forename: J C
authors.initials: JC
authors.lastname: Noel
authors.forename: M
authors.initials: M
authors.lastname: Vandenbossche
authors.forename: M O
authors.initials: MO
authors.lastname: Peny
authors.forename: A
authors.initials: A
authors.lastname: Sassine
authors.forename: G
authors.initials: G
authors.lastname: de Dobbeleer
authors.forename: C C
authors.initials: CC
authors.lastname: Schulman
authors.forename: A
authors.initials: A
authors.lastname: Verhest
mesh_terms: D000368:Aged; D002291:Carcinoma, Papillary / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology; D015344:DNA Probes, HPV; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D027383:Papillomaviridae / Q000145:classification*; D010412:Penile Neoplasms / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology
chemical_list: D015344:DNA Probes, HPV