title: Assessment of left ventricular dysfunction in acromegalic patients using radionuclide ventriculography parameters.
abstract: The left ventricular function of 14 acromegalic patients was investigated using radionuclide ventriculography. After labeling the red blood cells with 750-1,000 MBq 99mTc-pertechnetate, ECG-triggered left anterior oblique images were recorded. Fourier analysis was then performed on the time-activity curve of the left ventricle. The ejection fraction (EF), peak ejection rate, time to peak ejection (TPE), time to end-systole (TES), peak filling rate (PFR), time to peak filling (TPF), 1/3 EF, 1/3 filling fraction (FF), TPE/T, TPF/T and TES/T values (T: time interval for one heart beat) were calculated for each patient. Five patients (35.7%) had clinical cardiovascular symptoms. A decreased EF was observed in 28.5% of the patients. In comparison to the control group, the EF (53.5 +/- 5.5 vs. 60.8 +/- 5% p less than 0.009), 1/3 EF (14.45 +/- 3 vs. 20 +/- 4%, p less than 0.001), 1/3 FF (28.5 +/- 10.6 vs. 41 +/- 11%, p less than 0.02), TPE (158 +/- 33 vs. 132 +/- 35 ms, p less than 0.01), TPE/T (20.2 +/- 5 vs. 16 +/- 3.7, p less than 0.01) and PFR (2.4 +/- 0.5 vs. 2.9 +/- 0.4 EDC/s, p less than 0.005) were significantly different. It was found that TPE was prolonged and the early ejection function was decreased. Diastolic dysfunction was found in 5 (35.7%) patients; 21.4% of the patients had decreased PFR values although they had no cardiac symptom, hypertension and/or cardiomegaly. Scintigraphic parameters did not correlate with the presence of hypertension, cardiomegaly or cardiovascular symptoms.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Hacettepe University, Faculty of Medicine, Department of Endocrinology, Sihhiye-Ankara, Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Erbas
authors.forename: B
authors.initials: B
authors.lastname: Erbas
authors.forename: A
authors.initials: A
authors.lastname: Usman
authors.forename: C F
authors.initials: CF
authors.lastname: Bekdik
mesh_terms: D000172:Acromegaly / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D000328:Adult; D006332:Cardiomegaly / Q000000981:diagnostic imaging* / Q000209:etiology; D004912:Erythrocytes; D005260:Female; D015637:Gated Blood-Pool Imaging; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology; D013670:Sodium Pertechnetate Tc 99m; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D013670:Sodium Pertechnetate Tc 99m