Effect of intravenous hypnotics on the actions of pipecuronium.
Seventy-five ASA Grades I-III patients (18-85 years, 45-90 kg) were randomized into five groups. All patients received N2O/O2 (2/1) and alfentanil: loading dose (LD) 0.015 mg kg-1 and maintenance dose (MD) 0.045 mg kg-1 h-1 (groups 1-4). Group 1 received propofol (LD 2 mg kg-1 and MD 6 mg kg-1 h-1); Group 2 etomidate (LD 0.3 mg kg-1 and MD 0.6 mg kg-1 h-1); Group 3 midazolam (LD 0.2 mg kg-1 and MD 0.120 mg kg-1 h-1); Group 4 methohexitone (LD 1.5 mg kg-1 and MD 4 mg kg-1 h-1); Group 5 dehydrobenzperidol 0.05-0.23 mg kg-1 and alfentanil (LD 0.100 mg kg-1 and MD 0.060 mg kg-1 h-1). The neuromuscular block induced by pipecuronium (50 micrograms kg-1) was evaluated. No statistically significant differences were found between the five groups as concerned degree of block (expressed as % twitch amplitude in response to the first of the TOF stimuli (Ta1) at intubation, T1 minimum and recovery to Ta1 = 20%, 25% and 75%. Slightly faster intubation was possible when midazolam was used in comparison with propofol, methohexitone or NLA and when etomidate was used in comparison with propofol. A wide range of individual values of maximal neuromuscular blocking activity was found.
Dutre
P
P
Department of Anaesthesiology, University Hospital, Gent, Belgium.
Rolly
G
G
Vermeulen
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015113:Androstane-3,17-diol / Q000031:analogs & derivatives* / Q000494:pharmacology; D000771:Anesthesia, Intravenous; D004347:Drug Interactions; D005045:Etomidate; D006801:Humans; D008723:Methohexital; D008874:Midazolam; D008875:Middle Aged; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D009469:Neuromuscular Junction / Q000187:drug effects*; D017300:Pipecuronium; D010879:Piperazines / Q000494:pharmacology*; D015742:Propofol; D011897:Random Allocation
D009466:Neuromuscular Blocking Agents; D010879:Piperazines; D017300:Pipecuronium; D015113:Androstane-3,17-diol; D008723:Methohexital; D008874:Midazolam; D015742:Propofol; D005045:Etomidate