Case report 714. Postirradiation osteosarcoma after radiation of metastatic skeletal lesion.
Two cases of postirradiation osteosarcoma are presented--one in a 76-year-old woman with breast carcinoma and subsequent osteosarcoma after radiation therapy for a metastatic lesion in the right tibia, and the other in a 16-year-old girl with hepatocellular carcinoma metastatic to the left tibia and osteosarcoma after radiation therapy to that bone. Microscopically, both cases were high-grade spindle cell lesions with osteoid production. Both patients fared poorly. This is a rare complication of radiation therapy.
Toorkey
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BC
Section of Surgical Pathology, Mayo Clinic, Rochester, Minnesota 55905.
Unni
K K
KK
Dahlin
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DC
D000230:Adenocarcinoma / Q000532:radiotherapy / Q000556:secondary; D000293:Adolescent; D000368:Aged; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology / Q000532:radiotherapy; D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000556:secondary; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology; D009381:Neoplasms, Radiation-Induced / Q000000981:diagnostic imaging* / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000000981:diagnostic imaging / Q000473:pathology; D012516:Osteosarcoma / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D011859:Radiography; D011878:Radiotherapy / Q000009:adverse effects; D013977:Tibia / Q000000981:diagnostic imaging