Detection of human papillomavirus in vulvar carcinoma. A study by in situ hybridisation.
Fourty-four specimens of invasive cancers of the vulva, including 38 primary invasive squamous carcinomas, were analysed by in situ hybridisation with biotinylated HPV 6/11, 16 and 18 DNA probes. Four (9%) of the 44 carcinomas were positive for HPV DNA: three (7%) for HPV 16 DNA and one (2%) for HPV 6/11 DNA. HPV DNA was found only in squamous carcinomas. Of the 38 primary squamous carcinomas, 11% were positive (8% HPV 16, 3% HPV 6/11). The overall 5-year survival was 48.7%, 48.5% for the squamous carcinomas and 50.0% for the HPV DNA positive patients.
Brandenberger
A W
AW
Department of Obstetrics and Gynecology, University of Berne, Switzerland.
Rüdlinger
R
R
Hänggi
W
W
Bersinger
N A
NA
Dreher
E
E
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D015344:DNA Probes, HPV; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D009367:Neoplasm Staging; D027383:Papillomaviridae / Q000302:isolation & purification*; D014412:Tumor Virus Infections / Q000473:pathology*; D014844:Vulva / Q000473:pathology; D014846:Vulvar Neoplasms / Q000473:pathology*
D015344:DNA Probes, HPV