title: [Results of displacement studies on benzodiazepine receptors (123I-iomazenil and flumazenil)].
abstract: SPECT studies with 123I-iomazenil were performed in 14 patients with hepatic encephalopathy. The activity concentration in the brain decreases spontaneously by 10 to 20% within 80 min, in the nasal tissue by 35%. After an i.v. injection of 0.1 to 0.5 mg flumazenil a decrease of 29 to 38% is observed within 20 min, with a comparable decrease in white matter and nasal tissue. The application of well-known models of receptor kinetics is therefore impossible.
authors.affiliation: Nuklearmedizinische Klinik der Charité, Humboldt-Universität Berlin, FRG.
authors.forename: K
authors.initials: K
authors.lastname: Buchali
mesh_terms: D005442:Flumazenil / Q000031:analogs & derivatives*; D006501:Hepatic Encephalopathy / Q000000981:diagnostic imaging*; D006801:Humans; D007457:Iodine Radioisotopes; D011963:Receptors, GABA-A / Q000502:physiology*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D007457:Iodine Radioisotopes; D011963:Receptors, GABA-A; D005442:Flumazenil; C063038:iomazenil
vernacular_title: Ergebnisse von Verdrängungsuntersuchungen an Benzodiazepin-Rezeptoren (123J-Jomazenil und Flumazenil).