Anti-elastin antibodies in patients with lung cancer.
The aim of this study was to investigate anti-elastin antibodies of the IgG and IgM types in sera of patients suffering from lung cancer, using the DOT immunobinding assay. We studied 96 pathological and 40 control sera. Anti-elastin antibodies were found to be present in 45% of patients with small cell lung cancer, 19% of subjects with adenocarcinoma and not-identified lung tumor and 15% of patients with squamous cell lung cancer. They circulated in 5% of control persons only. The highest values of their titers were observed in the advanced stages of disease. In 55% of anti-elastin antibody positive small cell lung cancer patients, antibodies were of the IgM type, suggesting the initial step of the autoimmunization to elastin.
Gmiński
J
J
Department of Biochemistry and Chemistry, Silesian Medical Academy, Katowice, Poland.
Mykała-Cieśla
J
J
Machalski
M
M
Drózdz
M
M
D000230:Adenocarcinoma / Q000276:immunology*; D000912:Antibodies, Neoplasm / Q000276:immunology*; D018288:Carcinoma, Small Cell / Q000276:immunology*; D002294:Carcinoma, Squamous Cell / Q000276:immunology*; D004549:Elastin / Q000276:immunology*; D005260:Female; D006801:Humans; D015151:Immunoblotting; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D008175:Lung Neoplasms / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D000912:Antibodies, Neoplasm; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D004549:Elastin