[Effects of piracetam on Na(+)-K(+)-ATPase and monoamine oxidase in rat brain and its antioxidation effect].
Piracetam, ig 600 mg.kg-1.d-1 for 30 d, caused a 20% decrease in the activity of Na(+)-K(+)-ATPase and monoamine oxidase (MAO) in vivo. In vitro, it presented an inhibitory effect on MAO, but had no direct effect on Na(+)-K(+)-ATPase at a concentration of 100 mmol.L-1. Piracetam had a potential action in scavenging free radicals. This action may be related to its clinical effects on amnesia and Alzheimer's disease.
Qian
Z N
ZN
Department of Pharmacology, Suzhou Medical College, China.
Gu
Z L
ZL
Jin
L Q
LQ
Xie
M L
ML
Chen
B Q
BQ
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D005260:Female; D016166:Free Radical Scavengers; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D010084:Oxidation-Reduction; D010889:Piracetam / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013570:Synaptic Membranes / Q000201:enzymology
D016166:Free Radical Scavengers; D008995:Monoamine Oxidase; D000254:Sodium-Potassium-Exchanging ATPase; D010889:Piracetam