title: Piperacillin/tazobactam plus gentamicin as empirical therapy for febrile neutropenic patients with haematological malignancy.
abstract: The efficacy of piperacillin/tazobactam (PIPC/TBT) in combination with gentamicin was assessed as empirical therapy in 44 febrile neutropenic patients with haematological malignancy. A favourable response to therapy was seen in 67% patients overall and in 57% of patients with microbiologically documented infection. PIPC/TBT demonstrated good clinical and in vitro activity against isolated pathogens, particularly Gram positive cocci such as Staphylococcus epidermidis. The MIC of both Gram positive and Gram negative pathogens to PIPC was reduced in the presence of TBT. PIPC/TBT plus gentamicin is a safe and effective combination for empirical therapy in febrile neutropenic patients, even in a unit with a predominance of Gram positive infections.
authors.affiliation: Department of Haematology, Royal London Hospital, UK.
authors.forename: S M
authors.initials: SM
authors.lastname: Kelsey
authors.forename: B
authors.initials: B
authors.lastname: Weinhardt
authors.forename: C E
authors.initials: CE
authors.lastname: Pocock
authors.forename: E
authors.initials: E
authors.lastname: Shaw
authors.forename: A C
authors.initials: AC
authors.lastname: Newland
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects; D001424:Bacterial Infections / Q000188:drug therapy*; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D005260:Female; D005334:Fever / Q000188:drug therapy* / Q000209:etiology; D005839:Gentamicins / Q000627:therapeutic use; D006801:Humans; D007938:Leukemia / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D008223:Lymphoma / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009503:Neutropenia / Q000188:drug therapy* / Q000209:etiology; D010397:Penicillanic Acid / Q000627:therapeutic use; D010878:Piperacillin / Q000627:therapeutic use; D000078142:Tazobactam; D065093:beta-Lactamase Inhibitors
chemical_list: D000970:Antineoplastic Agents; D005839:Gentamicins; D065093:beta-Lactamase Inhibitors; D010397:Penicillanic Acid; D000078142:Tazobactam; D010878:Piperacillin