title: Psychiatric symptoms and mental changes as major features of multiple sclerosis.
abstract: A patient is presented with clinically and laboratory supported definite multiple sclerosis who developed severe depression followed by mental deterioration. Magnetic resonance imaging MRI demonstrated multiple hemispherical lesions. It is suggested that the psychiatric and cognitive signs and symptoms observed in this patient are due to severe cerebral demyelination.
authors.affiliation: Ignatius Hospital, Department of Neurology, Breda, The Netherlands.
authors.forename: E A
authors.initials: EA
authors.lastname: Sanders
authors.forename: H B
authors.initials: HB
authors.lastname: van Lieshout
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D003866:Depressive Disorder / Q000175:diagnosis* / Q000523:psychology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000523:psychology; D019965:Neurocognitive Disorders / Q000175:diagnosis* / Q000523:psychology; D009460:Neurologic Examination; D009483:Neuropsychological Tests