title: Changes in calcanean bone mineral occurring spontaneously and during hormone replacement therapy in early post-menopausal women.
abstract: The spontaneous calcanean bone loss occurring in healthy early post-menopausal women and the effect of two hormone replacement therapies (HRT's) were investigated in a longitudinal study. There was no difference between the right and left calcanean BMC or BMD (p > 0.15). The spontaneous bone loss was similar at all the skeletal sites measured, with a mean spontaneous loss in calcanean BMD of 1.6% over one year. Both HRT's significantly (p < 0.01) prevented the bone loss from all skeletal sites irrespective of the weight-bearing or content of trabecular bone, and (for the weight-bearing bones) there was even a gain in calcanean BMC and BMD and spinal BMD (p < 0.01). Bone mineral of the calcaneus and the spine correlated equally to body weight (r approximately 0.4, p < 0.001), whereas bone mineral in the forearm was not correlated to body weight. The correlations between the changes in bone mineral at the sites measured were all significant (r approximately 0.2-0.4).
authors.affiliation: Department of Clinical Chemistry, Glostrup Hospital, University of Copenhagen, Denmark.
authors.forename: O L
authors.initials: OL
authors.lastname: Svendsen
authors.forename: C
authors.initials: C
authors.lastname: Hassager
authors.forename: U
authors.initials: U
authors.lastname: Marslew
authors.forename: C
authors.initials: C
authors.lastname: Christiansen
mesh_terms: D015519:Bone Density / Q000187:drug effects*; D002111:Calcaneus / Q000187:drug effects* / Q000378:metabolism; D004359:Drug Therapy, Combination; D004958:Estradiol / Q000031:analogs & derivatives / Q000627:therapeutic use; D015914:Estrogen Replacement Therapy / Q000379:methods*; D004966:Estrogens, Conjugated (USP) / Q000627:therapeutic use; D005260:Female; D005542:Forearm; D006801:Humans; D016912:Levonorgestrel / Q000008:administration & dosage; D008137:Longitudinal Studies; D008159:Lumbar Vertebrae / Q000378:metabolism; D008593:Menopause / Q000378:metabolism*; D008875:Middle Aged
chemical_list: D004966:Estrogens, Conjugated (USP); D004958:Estradiol; D016912:Levonorgestrel