title: Effects induced by olive oil-rich diet on erythrocytes membrane lipids and sodium-potassium transports in postmenopausal hypertensive women.
abstract: Since we have observed that monounsaturated fatty acids (MUFA) enriched diet modifies red cell membrane lipids and cation transport systems in normotensive subjects, we similarly evaluated a group of hypertensive patients undergoing an analogous dietary modification. In a group of 18 moderately hypertensive women, the diet was supplemented for two months with olive oil (about 45 g/day), which replaced an equal amount of seasoning fats. Before and after this period, red cell fatty acid composition was evaluated by gas-chromatography in order to verify diet compliance: a significant increase in oleic acid was observed, while the content of saturated and polyunsaturated fatty acids remained unchanged. After olive oil, maximal rates of Na-K pump (5580 +/- 329 vs 6995 +/- 390, p less than 0.001) and Na-K cotransport (Na-COT 544 +/- 52 vs 877 +/- 46, p less than 0.001: K-COT 790 +/- 76 vs 1176 +/- 66, p less than 0.001), cell Na content (9.58 +/- 0.4 vs 10.61 +/- 0.6, p less than 0.03) and passive permeability for Na (936 +/- 74 vs 1836 +/- 102, p less than 0.001) rose significantly. Although the reduction in maximal rate of the Li-Na CT after olive oil was not significant, it was the only cation transport parameter being correlated with the variations of membrane lipids, namely negatively with UFA (r = -0.528, p less than 0.05) and positively with SFA (r = 0.482, p less than 0.005). The change in maximal rate of Li-Na CT was also correlated with the variation of systolic and diastolic BP (r = 0.50, p less than 0.03).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Istituto di Patologia Medica, Università di Verona, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Corrocher
authors.forename: A
authors.initials: A
authors.lastname: Pagnan
authors.forename: G B
authors.initials: GB
authors.lastname: Ambrosio
authors.forename: S
authors.initials: S
authors.lastname: Ferrari
authors.forename: O
authors.initials: O
authors.lastname: Olivieri
authors.forename: P
authors.initials: P
authors.lastname: Guarini
authors.forename: A
authors.initials: A
authors.lastname: Bassi
authors.forename: D
authors.initials: D
authors.lastname: Piccolo
authors.forename: A
authors.initials: A
authors.lastname: Gandini
authors.forename: D
authors.initials: D
authors.lastname: Girelli
mesh_terms: D001794:Blood Pressure / Q000187:drug effects; D002463:Cell Membrane Permeability / Q000187:drug effects; D002849:Chromatography, Gas; D004032:Diet; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D005227:Fatty Acids / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000178:diet therapy; D008094:Lithium / Q000097:blood; D008563:Membrane Lipids / Q000097:blood*; D008875:Middle Aged; D000069463:Olive Oil; D010938:Plant Oils; D011188:Potassium / Q000097:blood*; D012964:Sodium / Q000097:blood*; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects
chemical_list: D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D008563:Membrane Lipids; D000069463:Olive Oil; D010938:Plant Oils; D008094:Lithium; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium