title: MIC and disk diffusion quality control guidelines for Neisseria gonorrhoeae susceptibility tests of cefdinir, cefetamet, CI-960, fleroxacin, lomefloxacin, and temafloxacin.
abstract: Cefdinir (FK482), cefetamet (Ro 15-8074), CI-960, fleroxacin, lomefloxacin, and temafloxacin have potent activities against Neisseria gonorrhoeae. They were tested in a multilaboratory study to establish quality control guidelines. Quality control ranges for N. gonorrhoeae ATCC 49226 were determined by using multiple GC agar lots, three disk lots, and a number of test replicates consistent with the M23-T guidelines of the National Committee for Clinical Laboratory Standards. The MIC ranges included 2 to 4 log2 dilution steps. The recommended inhibition zone diameter ranges were generally 7 to 8 mm and included greater than or equal to 91.3% of all recorded study results.
authors.affiliation: Anti-Infectives Research Center, University of Iowa College of Medicine, Iowa City 52242.
authors.forename: M E
authors.initials: ME
authors.lastname: Erwin
authors.forename: R N
authors.initials: RN
authors.lastname: Jones
authors.forename: F P
authors.initials: FP
authors.lastname: Koontz
authors.forename: E H
authors.initials: EH
authors.lastname: Gerlach
authors.forename: P R
authors.initials: PR
authors.lastname: Murray
authors.forename: J A
authors.initials: JA
authors.lastname: Washington
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D000077525:Cefdinir; D015296:Ceftizoxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D004058:Diffusion; D016576:Fleroxacin / Q000494:pharmacology*; D024841:Fluoroquinolones; D008826:Microbial Sensitivity Tests / Q000592:standards*; D009344:Neisseria gonorrhoeae / Q000187:drug effects*; D011786:Quality Control; D015363:Quinolones / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D002511:Cephalosporins; D024841:Fluoroquinolones; D015363:Quinolones; C054745:temafloxacin; C047444:cefetamet; C057477:clinafloxacin; D015296:Ceftizoxime; D000077525:Cefdinir; C053091:lomefloxacin; D016576:Fleroxacin