title: Immobilization of human thrombomodulin on glass beads and its anticoagulant activity.
abstract: Human thrombomodulin (TM) was for the first time immobilized on glass beads by the reaction between the carboxyl group of TM and the amino group of glass beads using water-soluble carbodiimide. Immobilized human TM exhibited both anticoagulant activity and inhibition of platelet aggregation of human blood.
authors.affiliation: Department of Applied Chemistry and Chemical Engineering, Faculty of Engineering, Kagoshima University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Akashi
authors.forename: I
authors.initials: I
authors.lastname: Maruyama
authors.forename: N
authors.initials: N
authors.lastname: Fukudome
authors.forename: E
authors.initials: E
authors.lastname: Yashima
mesh_terms: D000925:Anticoagulants / Q000737:chemistry / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects; D005898:Glass; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000502:physiology*; D018179:Receptors, Thrombin
chemical_list: D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors; D011956:Receptors, Cell Surface; D018179:Receptors, Thrombin