title: [The efficacy of transarterial immuno-embolization therapy in patients with hepatocellular carcinoma].
abstract: The efficacy of transarterial immuno-embolization therapy (TIE) was investigated in 7 patients with multiple hepatocellular carcinoma (HCC). We administered OK-432 (10 KE), fibrinogen (30 mg/ml) and thrombin (1 U/ml) as a new treatment for HCC with intrahepatic metastasis. In all patients with a high level of AFP, the AFP level decreased promptly less than the pretreatment level after TIE therapy. High fever in all cases, epigastralgia in 6 cases and appetite loss in 3 cases were observed after TIE therapy. Our results indicate that this therapy may be a safe and effective method in HCC patients with intrahepatic metastasis.
authors.affiliation: Dept. of Surgery II, Osaka University Medical School.
authors.forename: J
authors.initials: J
authors.lastname: Shimizu
authors.forename: T
authors.initials: T
authors.lastname: Kanai
authors.forename: M
authors.initials: M
authors.lastname: Monden
authors.forename: M
authors.initials: M
authors.lastname: Sakon
authors.forename: M
authors.initials: M
authors.lastname: Gotoh
authors.forename: K
authors.initials: K
authors.lastname: Umeshita
authors.forename: T
authors.initials: T
authors.lastname: Tarui
authors.forename: T
authors.initials: T
authors.lastname: Monden
authors.forename: T
authors.initials: T
authors.lastname: Mori
authors.forename: K
authors.initials: K
authors.lastname: Tomoda
mesh_terms: D000284:Administration, Oral; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000556:secondary / Q000628:therapy*; D004621:Embolization, Therapeutic; D005340:Fibrinogen / Q000008:administration & dosage*; D005472:Fluorouracil / Q000008:administration & dosage; D006499:Hepatic Artery; D006801:Humans; D007167:Immunotherapy; D007459:Iodized Oil / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010844:Picibanil / Q000008:administration & dosage*; D013917:Thrombin / Q000008:administration & dosage
chemical_list: D010844:Picibanil; D007459:Iodized Oil; D005340:Fibrinogen; D013917:Thrombin; D005472:Fluorouracil