[Two-phase effect of endothelin-1 on resistance of coronary vessels in anesthesized rats with intact chest].
Effects of intracoronary infused (2 pM/kg/min for 5 min) endothelin-I on coronary blood flow was studied using modification of the method of Vetterlein and Schmidt. Blood flow in extracorporeal circuit was measured by 20 MHz pulsed Doppler flowmeter. One end of the circuit was connected to the left common carotid artery and the other was connected to the especially curved glass cannule which was placed to the origin of the coronary artery and through the right common carotid artery. Five-minute infusion of endothelin was followed by transitory dilatation and then by constriction of coronary vessels. Blockade of dihydropyridine-sensitive Ca-channels potentiated endothelin-induced vasodilation and decreased the constrictor response three-fold.
Medvedeva
N A
NA
University of Iowa, Iowa City.
Sheffer
R
R
Medvedev
O S
OS
D000818:Animals; D015220:Calcium Channels / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects; D003331:Coronary Vessels / Q000187:drug effects*; D004095:Dihydropyridines / Q000494:pharmacology; D016232:Endothelins / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014655:Vascular Resistance / Q000187:drug effects*; D014664:Vasodilation / Q000187:drug effects
D015220:Calcium Channels; D004095:Dihydropyridines; D016232:Endothelins; C038806:1,4-dihydropyridine
Dvukhfaznyĭ éffekt éndotelina-1 na soprotivlenie koronarnykh sosudov u narkotizirovannykh krys s intaktnoĭ grudnoĭ kletkoĭ.