A mechanism involved in the plaque enhancement effect of sodium thiosulfate for foot-and-mouth disease viruses.
A mechanism involved in the plaque enhancement effect of foot-and-mouth disease viruses (FMDV) by the addition of sodium thiosulfate (Hypo) in the agar overlay medium (AOM) previously reported was studied. It was experimentally proved that the diffusion of virus particles through agar overlay medium was enhanced when this salt was incorporated. Accordingly, the enlarged plaque formation was assumed to be caused by the enhanced diffusion of viral progenies produced in infectious centers during plaque assays.
Kadoi
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Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia, Brescia, Italy.
D000362:Agar; D000818:Animals; D005537:Aphthovirus / Q000187:drug effects* / Q000254:growth & development; D013885:Thiosulfates / Q000494:pharmacology*; D010948:Viral Plaque Assay
D013885:Thiosulfates; D000362:Agar; C017717:sodium thiosulfate