Comparison of mu opioid receptors in brains of rats bred for high or low rate of self-stimulation.
Opiates and endogenous opioid peptides play an important role in reward-mediated behaviors, including self-stimulation. Two strains of rats, LC2-Hi and LC2-Lo, selectively bred for high vs. low rate of lateral hypothalamic self-stimulation, were employed in the present study. Quantitative autoradiography was performed on brains of adult male rats of each strain, using the mu opioid receptor agonist 3H-DAGO. Strain differences in receptor density were observed in the nucleus accumbens and in ventral areas of the hippocampus.
Gross-Isseroff
R
R
Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
Cohen
E
E
Shavit
Y
Y
D000818:Animals; D001143:Arousal / Q000235:genetics* / Q000502:physiology; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D005838:Genotype; D009714:Nucleus Accumbens / Q000502:physiology; D051381:Rats; D011957:Receptors, Opioid / Q000235:genetics* / Q000502:physiology; D017450:Receptors, Opioid, mu; D012641:Selection, Genetic; D012653:Self Stimulation / Q000502:physiology*; D013045:Species Specificity
D011957:Receptors, Opioid; D017450:Receptors, Opioid, mu