Prognostic significance of cytochemical analysis of leukemic M2 blasts.
Cytochemical analysis of leukemic blasts from 46 patients with acute myeloblastic M2 leukemia (according to the FAB classification) was performed before and after cytostatic therapy, and compared with findings obtained in 20 age- and sex-matched control subjects. Cytochemical findings for myeloperoxidase (MPO), Sudan black B, acid phosphatase and alpha-naphthyl-acetate esterase (ANAE) were related to the achievement of the first complete remission (CR), i.e. data were compared after the patients had been divided into CR and non-CR groups. The analysis clearly showed that a high proportion of myeloperoxidase- and, to a lesser extent, Sudan black B-positive blasts before treatment may have constituted a significantly unfavourable prognostic factor.
Suĭć
M
M
Department of Clinical Laboratory Diagnosis, Zagreb University School of Medicine, Croatia.
Boban
D
D
Marković-Glamocak
M
M
Petrovecki
M
M
Marusić
M
M
Labar
B
B
D000135:Acid Phosphatase / Q000032:analysis; D000293:Adolescent; D000328:Adult; D000368:Aged; D001391:Azo Compounds / Q000032:analysis; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000201:enzymology* / Q000276:immunology*; D007962:Leukocytes / Q000201:enzymology*; D008213:Lymphocyte Activation; D008875:Middle Aged; D009281:Naphthalenes; D009283:Naphthol AS D Esterase / Q000032:analysis; D009195:Peroxidase / Q000032:analysis; D011379:Prognosis; D012074:Remission Induction
D001391:Azo Compounds; D009281:Naphthalenes; C016118:Sudan Black B; D009195:Peroxidase; D009283:Naphthol AS D Esterase; D000135:Acid Phosphatase