[Phosphoinositide metabolism in rat cerebral cortex sections in anoxia and after restoration of oxygen supply].
The work deals with the study of the content and intensity of metabolism of phosphate groups in phosphatidylinositol (monophosphoinositides--MPI), phosphatidylinositol-4-phosphates (diphosphoinositides--DPI), and phosphatidylinositol-4,5-diphosphates (triphosphoinositides--TPI) of sections of the rat cerebral hemisphere cortex in 50-second, 2.5- and 6-minute anoxia and 15 and 60 minutes after restoration of oxygen supply (after 5-minute anoxia). Mild phase fluctuations occur in the TPI and DPI content during anoxia, while the MPI content does not change. The intensity of metabolism of all phosphoinositides (PI) is diminished in all periods of anoxia. During reoxygenation the TPI and DPI content is normalized and their relative specific radioactivity undergoes phase changes. The intensity of metabolism of all PI, particularly that of MPI, increases 15 minutes after restoration of oxygen supply. In 60 minutes the relative specific radioactivity of all PI does not differ from that in the controls.
Raĭze
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Kiselev
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GV
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D002534:Hypoxia, Brain / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D010100:Oxygen / Q000494:pharmacology*; D010716:Phosphatidylinositols / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D010716:Phosphatidylinositols; D010100:Oxygen
Metabolizm fosfoinozitidov v srezakh kory golovnogo mozga krys pri anoksii i posle vosstanovleniia kislorodnogo snabzheniia.