title: Modulation of food and water intake by catecholamines injected into the lateral ventricle of the pigeon brain.
abstract: The effects of noradrenaline, adrenaline and dopamine on food and water intake were investigated in satiated (food ad libitum) adult pigeons weighing 320-360 g (N = 10 per group). Catecholamines (80 nmol in 1 microliter of saline) were injected into the right lateral ventricle. A significant increase in food consumption during the first hour was induced only by noradrenaline (8.1 +/- 1.8 g) and adrenaline (8.0 +/- 2.7 g) vs 1.9 +/- 0.6 g for the saline control. Noradrenaline also caused a significant drop during the second hour (1.7 +/- 0.6 g vs 3.5 +/- 0.7 g for the saline control). Dopamine decreased food intake at 2 h (1.4 +/- 0.3 g vs 3.5 +/- 0.7 g for the saline control) and 3 h (1.4 +/- 0.4 g vs 3.2 +/- 0.7 g for the saline control) post-injection, with a subsequent elevation in the feeding response during the 4th h (4.9 +/- 0.9 g vs 2.6 +/- 0.7 g for the saline control). The total food ingestion for the 6-h period was similar for the control and experimental groups. Water consumption was not significantly affected by any catecholamine during any specific period but total ingestion was increased by noradrenaline (44.7 +/- 3.0 ml vs 29.6 +/- 5.1 ml for the saline control). These results suggest that catecholamines are involved in the neural control of food, but not water, intake in pigeons.
authors.affiliation: Departamento de Ciências Fisiológicas, Universidade Federal de Santa Catarina, Florianópolis, Brasil.
authors.forename: M R
authors.initials: MR
authors.lastname: Ravazio
authors.forename: M A
authors.initials: MA
authors.lastname: Paschoalini
mesh_terms: D000818:Animals; D001069:Appetite Regulation / Q000187:drug effects*; D002395:Catecholamines / Q000008:administration & dosage*; D010856:Columbidae / Q000502:physiology*; D004298:Dopamine / Q000008:administration & dosage; D004326:Drinking / Q000187:drug effects*; D004837:Epinephrine / Q000008:administration & dosage; D005260:Female; D007276:Injections, Intraventricular; D008297:Male; D009638:Norepinephrine / Q000008:administration & dosage; D013997:Time Factors
chemical_list: D002395:Catecholamines; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine