title: Loco-regional nodal relapse in melanoma.
abstract: Two-hundred and seven patients without evidence of disease following lymph node dissection (LND) were stratified into three groups: Group A, lymph node relapse within the site of prior LND; Group B, lymph node relapse in a different, but regional, lymph node group; Group C, no lymph node relapse. Decreased survival was noted in both Groups A and B versus Group C. Prognostic factors were identified as: (i) axial or subungal/volar (subvolar) location and the number of positive lymph nodes at initial LND for nodal relapse within the same lymph node group; (ii) male gender, axial/subvolar location, and the number of histologically positive lymph nodes at initial LND for nodal relapse in a different, but regional lymph node group; (iii) relapse within the initial LND site for a decreased survival. Six of 10 patients with both axial/subvolar primaries and four or more positive lymph nodes developed a relapse within the dissection site post-LND. These prognostic factors describe a subset of patients who would be candidates for postoperative adjuvant local/regional and systemic therapy trials.
authors.affiliation: Department of Surgery, University of Pennsylvania, Philadelphia.
authors.forename: E J
authors.initials: EJ
authors.lastname: Miller
authors.forename: J M
authors.initials: JM
authors.lastname: Daly
authors.forename: M
authors.initials: M
authors.lastname: Synnestvedt
authors.forename: D
authors.initials: D
authors.lastname: Schultz
authors.forename: D
authors.initials: D
authors.lastname: Elder
authors.forename: D
authors.initials: D
authors.lastname: Guerry
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008545:Melanoma / Q000401:mortality* / Q000601:surgery; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000401:mortality*; D015143:Philadelphia / Q000453:epidemiology; D011379:Prognosis; D011446:Prospective Studies; D017678:Sex Distribution; D012878:Skin Neoplasms / Q000401:mortality* / Q000601:surgery; D016019:Survival Analysis