The effect of nizatidine on neuromuscular transmission.
The effect of the H2-receptor antagonist, nizatidine, on neuromuscular transmission was investigated using sciatic nerve-gastrocnemius muscle preparations of rat in vivo. Nizatidine, administered by i.v. injection, potentiates the neuromuscular blockade induced by d-tubocurarine, pancuronium and the aminoglycoside antibiotic, kanamycin. Moreover, the drug alone is capable of producing a blockade on preparations stimulated at high frequency. The neuromuscular blockade induced by nizatidine is reversed by 4-aminopyridine but not by dimaprit.
Bossa
R
R
Department of Pharmacology, Chemotherapy and Toxicology Emilio Trabucchi, University of Milan, Italy.
Baggio
G
G
Caffero
L
L
Castelli
M
M
Chiericozzi
M
M
Efstathiu
G
G
Galatulas
I
I
D015761:4-Aminopyridine / Q000494:pharmacology; D000818:Animals; D017259:Dimaprit / Q000494:pharmacology; D004357:Drug Synergism; D007612:Kanamycin / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D016567:Nizatidine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010197:Pancuronium / Q000494:pharmacology; D051381:Rats; D012584:Sciatic Nerve / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects; D014403:Tubocurarine / Q000494:pharmacology
D007612:Kanamycin; D015761:4-Aminopyridine; D010197:Pancuronium; D016567:Nizatidine; D014403:Tubocurarine; D017259:Dimaprit