Influence of anti-inflammatory drugs and free radical scavengers on intestinal ischemia induced oxidative tissue damage.
The influence of oxygen free radical scavengers and anti-inflammatory drugs on postischemic lipid peroxidation and myeloperoxidase activity was shown. The best results were obtained from vitamin E and the antiinflammatory treatment with CP and SUL, whereas an iron elimination only showed slight effects on myeloperoxidase activity above all. In experiments without therapy a linear increase of lipid peroxides dependent on reperfusion durance was found, whereas myeloperoxidase already showed a remarkable increase during ischemia and early reperfusion. This difference can be interpreted by scavenging mechanisms, which are overcharged after an appointed durance of reperfusion.
Augustin
A J
AJ
Physiologisches Institut der Universitaet, Wuerzburg, F.R.G.
Goldstein
R K
RK
Milz
J
J
Lutz
J
J
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology; D016166:Free Radical Scavengers; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000098:blood supply* / Q000293:injuries; D007501:Iron / Q000378:metabolism; D007511:Ischemia / Q000188:drug therapy* / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000188:drug therapy / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D016166:Free Radical Scavengers; D008054:Lipid Peroxides; D014810:Vitamin E; D007501:Iron; D009195:Peroxidase