title: Cytogenetical observations in two cases of polymorphous low-grade adenocarcinoma of the salivary glands.
abstract: The cytogenetical findings in two cases of cultured salivary polymorphous low-grade adenocarcinoma (PLGA) are reported. The first PLGA was a carcinoma ex pleomorphic adenoma of the parotid gland. This had a pseudodiploid stemline characterized by extensive and complicated structural rearrangements. The chromosomal findings showed many similarities to those in the only previously studied case of PLGA (also a carcinoma ex pleomorphic adenoma of the parotid). The results in both could fit with abnormalities superimposed on those typical of mixed tumors. The second PLGA reported derived from a minor salivary gland. It showed a completely different picture, distinguished by a hypodiploid, almost exclusively numerical, variation and the occurrence of a stemline characterized by only monosomy 22. Etiological differences were proposed as one possible explanation for the cytogenetical differences between the two types of PLGA.
authors.affiliation: Department of Pathology and Cytogenetics, Central Hospital, Skövde, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Mark
authors.forename: R
authors.initials: R
authors.lastname: Dahlenfors
authors.forename: G
authors.initials: G
authors.lastname: Stenman
authors.forename: M
authors.initials: M
authors.lastname: Bende
authors.forename: I
authors.initials: I
authors.lastname: Melén
mesh_terms: D008949:Adenoma, Pleomorphic / Q000235:genetics* / Q000473:pathology; D000293:Adolescent; D000368:Aged; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008297:Male; D010307:Parotid Neoplasms / Q000235:genetics* / Q000473:pathology; D012468:Salivary Gland Neoplasms / Q000235:genetics* / Q000473:pathology; D012470:Salivary Glands, Minor
chemical_list: D005819:Genetic Markers