title: Recent developments in the molecular cloning and characterization of hepatitis C and E viruses.
abstract: The molecular properties of the genomes of both hepatitis C virus (HCV) and hepatitis E virus (HEV), the major etiologic agents of non-A, non-B hepatitis, are briefly described. The organization of the genome of each of these viruses is discussed and compared to those of other related or distantly related viruses that contain single-stranded, positive-sense RNA genomes. In the case of HEV, the reactivity of expressed proteins and genetic divergence of geographically distinct isolates are also described within the context of sequence variation, type-common epitopes and type-specific epitopes.
authors.affiliation: Hepatitis Branch, Centers for Disease Control, Atlanta, GA 30333.
authors.forename: D W
authors.initials: DW
authors.lastname: Bradley
authors.forename: M J
authors.initials: MJ
authors.lastname: Beach
authors.forename: M A
authors.initials: MA
authors.lastname: Purdy
mesh_terms: D003001:Cloning, Molecular; D016679:Genome, Viral; D016174:Hepacivirus / Q000235:genetics*; D016752:Hepatitis E virus / Q000235:genetics*