Clinical and pharmacokinetic effects of a diet rich in insoluble fiber on Parkinson disease.
In this study, the effects of a diet rich in insoluble fiber (DRIF) on motor disability and the peripheral pharmacokinetics of orally administered L-dopa in Parkinsonian patients with marked constipation are analyzed. We found a useful effect of a DRIF on plasma L-dopa concentration and motor function. The greatest effect on the plasma L-dopa levels was found early (at 30 and 60 min) after oral administration. There was a relationship between the improvement of constipation and the higher bioavailability of L-dopa. DRIF can be a coadjuvant treatment in patients with Parkinson's disease.
Astarloa
R
R
Service of Neurology, Jiménez Díaz Foundation, Madrid, Spain.
Mena
M A
MA
Sánchez
V
V
de la Vega
L
L
de Yébenes
J G
JG
D000284:Administration, Oral; D000368:Aged; D003248:Constipation / Q000188:drug therapy; D004043:Dietary Fiber / Q000494:pharmacology*; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D007980:Levodopa / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009069:Movement Disorders / Q000188:drug therapy; D010300:Parkinson Disease / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D011597:Psychomotor Performance / Q000187:drug effects; D013997:Time Factors
D004043:Dietary Fiber; D007980:Levodopa