Cannabinoid receptor agonists inhibit Ca current in NG108-15 neuroblastoma cells via a pertussis toxin-sensitive mechanism.
Cannabinoid receptor ligands irreversibly inhibited peak voltage-activated Ca currents (44%) in NG108-15 cells; this inhibition was Pertussis toxin-sensitive. Inhibition was largely due to a reduction in the omega-conotoxin sensitive portion of high-voltage activated (HVA) current, although there was also a significant decrease in low-voltage activated current (56%) and in the nifedipine-sensitive portion of HVA current (41%).
Caulfield
M P
MP
Department of Pharmacology, University College London.
Brown
D A
DA
D000700:Analgesics / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002186:Cannabinoids / Q000494:pharmacology*; D003511:Cyclohexanols / Q000494:pharmacology; D013759:Dronabinol / Q000494:pharmacology; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D009447:Neuroblastoma / Q000378:metabolism*; D010456:Peptides, Cyclic / Q000494:pharmacology; D037342:Pertussis Toxin; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug / Q000187:drug effects*; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D010566:Virulence Factors, Bordetella / Q000494:pharmacology*; D020960:omega-Conotoxins
D000700:Analgesics; D002121:Calcium Channel Blockers; D002186:Cannabinoids; D003511:Cyclohexanols; D010456:Peptides, Cyclic; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug; D010566:Virulence Factors, Bordetella; D020960:omega-Conotoxins; C053423:Conus magus toxin; D013759:Dronabinol; C054649:3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol; D037342:Pertussis Toxin; D019204:GTP-Binding Proteins