Circulating concentrations of fetal fibronectin do not reflect reduced trophoblastic invasion in preeclamptic pregnancies.
This prospective, nested, case-control study investigated whether maternal plasma fetal fibronectin reflects reduced trophoblastic invasion at 16 to 20 weeks in women who later have preeclampsia. Concentrations of fetal fibronectin were 8.7 +/- 2.6 micrograms/ml in women with preeclampsia and 8.1 +/- 2.5 micrograms/ml in matched controls (p greater than 0.5). These results are discussed.
Friedman
S A
SA
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco.
de Groot
C J
CJ
Taylor
R N
RN
Roberts
J M
JM
D016022:Case-Control Studies; D005260:Female; D005312:Fetal Blood; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D009361:Neoplasm Invasiveness; D009994:Osmolar Concentration; D011225:Pre-Eclampsia / Q000150:complications*; D011247:Pregnancy; D011446:Prospective Studies; D012016:Reference Values; D014328:Trophoblastic Neoplasms / Q000150:complications / Q000473:pathology*
D005353:Fibronectins