title: Differential expression of two sodium channel subtypes in human brain.
abstract: Two partial human brain sodium channel cDNA sequences (designated HBSC I and II) have been cloned and mapped to chromosome 2q23-2q24 by chromosome microdissection-PCR (CMPCR). The distribution of HBSC I and II mRNA in human brain was studied by means of a novel approach based on the ligase detection reaction. These studies demonstrate that HBSC I and II mRNA is heterogeneously distributed in brain, and that the relative ratio of the two forms can vary as much as 7-fold between different regions.
authors.affiliation: Department of Psychiatry, University of Alabama, Birmingham 35294.
authors.forename: C M
authors.initials: CM
authors.lastname: Lu
authors.forename: J
authors.initials: J
authors.lastname: Han
authors.forename: T A
authors.initials: TA
authors.lastname: Rado
authors.forename: G B
authors.initials: GB
authors.lastname: Brown
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D001921:Brain / Q000378:metabolism*; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000378:metabolism; D012689:Sequence Homology, Nucleic Acid; D015222:Sodium Channels / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D015222:Sodium Channels; D004247:DNA