In vitro activities of penciclovir and acyclovir against herpes simplex virus types 1 and 2.
Penciclovir (PCV) and acyclovir are acyclic guanine analogs which inhibit herpes simplex virus (HSV) DNA polymerase. Their 50% infective doses were 0.5 to 0.8 microgram/ml for clinical isolates of HSV-1 and 1.3 to 2.2 micrograms/ml for HSV-2. Furthermore, HSV-infected cultures receiving 2-h pulses of PCV had 2- to 50-fold less HSV than acyclovir-treated cultures, consistent with the prolonged intracellular half-life of PCV triphosphate.
Weinberg
A
A
Pediatric Infectious Diseases, University of Colorado School of Medicine, Denver 80262.
Bate
B J
BJ
Masters
H B
HB
Schneider
S A
SA
Clark
J C
JC
Wren
C G
CG
Allaman
J A
JA
Levin
M J
MJ
D000212:Acyclovir / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D006147:Guanine; D006207:Half-Life; D006801:Humans; D018139:Simplexvirus / Q000187:drug effects*
D000998:Antiviral Agents; C053539:penciclovir; D006147:Guanine; D004259:DNA-Directed DNA Polymerase; D000212:Acyclovir