Lambert-Eaton myasthenic syndrome without anti-calcium channel antibody: adverse effect of calcium antagonist diltiazem.
A 59 year old man with ischaemic heart disease, developed the clinical and electromyographic changes of the Lambert-Eaton myasthenic syndrome after taking calcium antagonist, diltiazem. The symptoms appeared periodically with a rise and fall in serum level of diltiazem. Extensive search was made for systemic neoplasms and autoimmune diseases without success. Serum antibody to voltage operated calcium channel was not detected.
Ueno
S
S
Second Department of Internal Medicine, Osaka University Medical School, Japan.
Hara
Y
Y
D001323:Autoantibodies / Q000032:analysis*; D015220:Calcium Channels / Q000187:drug effects / Q000276:immunology*; D003327:Coronary Disease / Q000188:drug therapy*; D003937:Diagnosis, Differential; D004110:Diltiazem / Q000009:adverse effects* / Q000627:therapeutic use; D004576:Electromyography / Q000187:drug effects; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination / Q000187:drug effects
D001323:Autoantibodies; D015220:Calcium Channels; D004110:Diltiazem