Human papillomavirus in breast cancer.
Histological sections from paraffin-embedded breast carcinoma and axillary lymph nodes were examined for the presence of human papillomaviruses by two different techniques: the polymerase chain reaction (PCR) and the in situ hybridization with biotin-labelled probes. By PCR we detected HPV 16 DNA sequences in 29.4% of breast tumours and in some metastatic lymph nodes, though we were unable to identify any HPV DNA sequences by in situ hybridization. These results suggest that HPV's could play a role in the genesis of breast neoplasia.
Di Lonardo
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Regina Elena Institute for Cancer Research, CRS, Rome, Italy.
Venuti
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Marcante
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ML
D001943:Breast Neoplasms / Q000382:microbiology*; D002277:Carcinoma / Q000382:microbiology*; D015344:DNA Probes, HPV; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000382:microbiology*; D027383:Papillomaviridae / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction
D015344:DNA Probes, HPV