title: The effect of chronic fluoride administration on rat condylar cartilage.
abstract: Morphometrical and histochemical techniques were used to demonstrate changes to the cartilage layer of the rat temporomandibular joint condyle following chronic exposure to fluoride. An increase in thickness of the cartilage layer was noted in rats given 100 parts per million sodium fluoride in drinking water. No significant changes were observed with either control or low dose (10 parts per million) groups. The observed thickening was attributable to an increase in number and size of cells of the lower hypertrophic zone. Accumulations of glycogen were observed in these cells, which reflects the inhibitory effect of fluoride on glycolysis. Stimulation of chondrocytes by fluoride may have delayed the normal processes of capillary invasion, resulting in thickening of the cartilage layer. No changes to staining patterns of immature or mature types of collagen were observed, nor did the staining pattern of detectable glycosaminoglycans change due to fluoride.
authors.affiliation: Department of Dentistry, University of Queensland.
authors.forename: D J
authors.initials: DJ
authors.lastname: Harbrow
authors.forename: M G
authors.initials: MG
authors.lastname: Robinson
authors.forename: P A
authors.initials: PA
authors.lastname: Monsour
mesh_terms: D000818:Animals; D002356:Cartilage / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology; D002467:Cell Nucleus / Q000648:ultrastructure; D002809:Chondroitin Sulfates / Q000032:analysis; D003094:Collagen / Q000032:analysis; D003593:Cytoplasm / Q000648:ultrastructure; D004334:Drug Administration Schedule; D006003:Glycogen / Q000032:analysis; D006984:Hypertrophy; D002479:Inclusion Bodies / Q000737:chemistry / Q000648:ultrastructure; D007632:Keratan Sulfate / Q000032:analysis; D008335:Mandibular Condyle / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D012969:Sodium Fluoride; D006003:Glycogen; D002809:Chondroitin Sulfates; D003094:Collagen; D007632:Keratan Sulfate