Cytomegalovirus (CMV) pneumonitis in AIDS patients: the result of intensive CMV replication?
We report a case of fatal pulmonary disease in a patient infected with human immunodeficiency virus (HIV), where cytomegalovirus (CMV) was the only causative agent identified in the lungs at autopsy. The most prominent histopathological features were numerous interalveolar cells containing CMV inclusion bodies combined with scanty signs of inflammation. We propose that the lung damage caused by CMV in acquired immune deficiency syndrome (AIDS) patients is a direct consequence of cytopathogenic effects of the virus related to the extent of active virus replication.
Aukrust
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P
Medical Dept A, University of Oslo, National Hospital, Norway.
Farstad
I N
IN
Frøland
S S
SS
Holter
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E
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D000328:Adult; D003587:Cytomegalovirus / Q000302:isolation & purification / Q000472:pathogenicity* / Q000502:physiology; D003586:Cytomegalovirus Infections / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D003588:Cytopathogenic Effect, Viral / Q000502:physiology; D006801:Humans; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure; D008168:Lung / Q000382:microbiology* / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D009894:Opportunistic Infections / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D011024:Pneumonia, Viral / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D014779:Virus Replication / Q000502:physiology*