Effects of foetal treatment with methylazoxymethanol on noradrenergic synapses in rat cerebral cortex.
Methylazoxymethanol (MAM)-induced cerebral hypoplasia resulted in a significant increase in densities of norepinephrine uptake sites in cerebral cortex, suggesting that norepinephrinergic axon terminals were compressed in the smaller brain volumes. The density of beta-adrenergic receptors in MAM-lesioned cerebral cortex was decreased probably due to down-regulation, while there were no changes in the proportions and affinities of agonist high-affinity sites and agonist low-affinity sites in the desensitized beta-receptors.
Watanabe
M
M
Department of Psychiatry, National Defense Medical College, Saitama, Japan.
Kinuya
M
M
Ohtakeno
S
S
Watanabe
H
H
Mamiya
G
G
D000477:Alkylating Agents / Q000633:toxicity*; D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects*; D004082:Dihydroalprenolol / Q000494:pharmacology; D005260:Female; D005333:Fetus / Q000187:drug effects / Q000378:metabolism; D007545:Isoproterenol / Q000494:pharmacology; D008024:Ligands; D008746:Methylazoxymethanol Acetate / Q000031:analogs & derivatives* / Q000633:toxicity; D008938:Mitosis / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D013569:Synapses / Q000378:metabolism*
D000477:Alkylating Agents; D008024:Ligands; D011943:Receptors, Adrenergic, beta; D008746:Methylazoxymethanol Acetate; D004082:Dihydroalprenolol; C030667:methylazoxymethanol; D007545:Isoproterenol; D009638:Norepinephrine