Macrophage association of polyomavirus in progressive multifocal leukoencephalopathy: an immunohistochemical and ultrastructural study. Case report.
Progressive multifocal leukoencephalopathy (PML) in a patient following autologous bone marrow transplantation for a non-Hodgkin's centroblastic lymphoma was studied by immunohistochemistry and transmission electron microscopy. Our observations indicate that a large amount of polyomavirus, most probably JC virus, is taken up and segregated within vacuoles of macrophages by phagocytosis. A relevant role of macrophages in the pathogenesis of PML is emphasized.
Mesquita
R
R
Immunopathology Laboratory, Karolinska Hospital, Stockholm, Sweden.
Parravicini
C
C
Björkholm
M
M
Ekman
M
M
Biberfeld
P
P
D001921:Brain / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007577:JC Virus / Q000254:growth & development; D007968:Leukoencephalopathy, Progressive Multifocal / Q000382:microbiology* / Q000473:pathology; D008264:Macrophages / Q000382:microbiology*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D011120:Polyomavirus / Q000254:growth & development*