New antiviral antibiotics, cycloviracins B1 and B2. I. Production, isolation, physico-chemical properties and biological activity.
Kibdelosporangium albatum No. R761-7 (ATCC 55061) produced new antiviral antibiotics, cycloviracins B1 and B2. They show weak activity against Gram-positive bacteria and potent antiviral activity against herpes simplex virus type 1. Unique acylsaccharide structures were established for cycloviracins B1 and B2 by degradation and spectroscopic analysis.
Tsunakawa
M
M
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
Komiyama
N
N
Tenmyo
O
O
Tomita
K
K
Kawano
K
K
Kotake
C
C
Konishi
M
M
Oki
T
T
D000192:Actinomycetales / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D018139:Simplexvirus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D018942:Macrolides; C077636:cycloviracin B1; C077637:cycloviracin B2