title: Alterations in monoamine receptors in the brain of suicide victims.
abstract: Suicide has been linked to alterations in the serotonergic and noradrenergic systems. Using in vitro quantitative receptor autoradiography, we compared the binding of 125I-lysergic acid diethylamide (5-hydroxytryptamine-2 sites) and 125I-pindolol (beta-adrenergic sites) with slide-mounted sections from the prefrontal and the temporal cortex of a group of suicide victims, matched to control specimens on postmortem interval, age, sex, and race. A specific laminar distribution of 5-hydroxytryptamine-2 binding was found in both groups, with layers III and IV having the highest level of binding, but beta-adrenergic binding did not differ across cortical layers. Binding to both 125I-lysergic acid diethylamide and 125I-pindolol was increased in the prefrontal cortex of the suicide victims, whereas only beta-adrenergic binding was increased in the temporal cortex of the suicide group.
authors.affiliation: Laboratory of Neuropharmacology, Western Psychiatric Institute and Clinic, University of Pittsburgh, PA 15213.
authors.forename: V
authors.initials: V
authors.lastname: Arango
authors.forename: M D
authors.initials: MD
authors.lastname: Underwood
authors.forename: J J
authors.initials: JJ
authors.lastname: Mann
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001345:Autoradiography; D001931:Brain Mapping; D003866:Depressive Disorder / Q000473:pathology* / Q000523:psychology; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000502:physiology; D011869:Radioligand Assay; D011941:Receptors, Adrenergic / Q000502:physiology*; D011985:Receptors, Serotonin / Q000502:physiology*; D012701:Serotonin / Q000502:physiology; D013405:Suicide / Q000523:psychology*; D013702:Temporal Lobe / Q000473:pathology*
chemical_list: D011941:Receptors, Adrenergic; D011985:Receptors, Serotonin; D012701:Serotonin; D009638:Norepinephrine