[Alpha 1-adrenergic receptors in the liver parenchyma of children: the changes in cirrhosis].
In the present study alpha 1-adrenergic receptors have been investigated in liver parenchyma, obtained at the resection of prehepatic portal hypertension children without parenchymal affection (control group, n = 7) and the resection of children in parenchymal affection (group of cirrhosis, n = 8). It has been shown, that the binding of alpha 1-adrenergic antagonist 3H-prasozin (3H-PRZ) in liver parenchyma membranes of both control and cirrhosis groups is saturable and shows a high affinity. The Scatchard analysis of the binding data indicated that the binding site is characterized by Kd and Bmax of 0.6 +/- 0.12 nM, 92.8 +/- 8.0 fmol/mg, respectively, for the control group; and 1.5 +/- 0.4 nM, 254.1 +/- 28.4 fmol/mg, respectively, for the group of cirrhosis; (mean +/- SEM). It has been found that the number of binding sites of 3H-PRZ significantly increases in cirrhosis liver parenchyma in comparison with the control group. The results obtained suggest that alpha 1-adrenergic receptors play an important role in cirrhosis formation in children, showing liver parenchyma affection severity and its regenerative properties.
Kondratenko
T Ia
TIa
Kuzina
N V
NV
Zakharova
I V
IV
Leont'ev
A F
AF
Pashkevich
D D
DD
Seniakovich
V M
VM
Aleksandrov
A E
AE
Klochkov
S A
SA
D000293:Adolescent; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D006801:Humans; D006975:Hypertension, Portal / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000737:chemistry* / Q000473:pathology; D008103:Liver Cirrhosis / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D011869:Radioligand Assay; D011942:Receptors, Adrenergic, alpha / Q000032:analysis*
D011942:Receptors, Adrenergic, alpha
Al'fa 1-adrenergicheskie retseptory v parenkhime pecheni u deteĭ: izmeneniia pri tsirroze.