L-cysteine augments the vasorelaxation induced by sodium nitrite and SIN-1 but not that due to acetylcholine.
The effects of 1 mM L-cysteine on sodium nitrite-, 3-morpholinosydnonimine (SIN-1)- and acetylcholine-induced relaxation and cyclic GMP accumulation were studied in isolated noradrenaline-precontracted rat mesenteric arterial rings. L-Cysteine augmented the relaxation and cyclic GMP increase induced by sodium nitrate and SIN-1 but not those induced by acetylcholine. The effects of L-cysteine on relaxation were independent of the presence of intact endothelium. The results suggest that L-cysteine protects exogenously released nitric oxide.
Arvola
P
P
Department of Biomedical Sciences, University of Tampere, Finland.
Pörsti
I
I
Vuorinen
P
P
Huhtala
H
H
Metsä-Ketelä
T
T
Vapaatalo
H
H
D000109:Acetylcholine / Q000008:administration & dosage; D000818:Animals; D006152:Cyclic GMP / Q000378:metabolism; D003545:Cysteine / Q000008:administration & dosage / Q000494:pharmacology*; D004357:Drug Synergism; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects / Q000502:physiology; D008981:Molsidomine / Q000008:administration & dosage / Q000031:analogs & derivatives; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012977:Sodium Nitrite / Q000008:administration & dosage; D014664:Vasodilation / Q000187:drug effects* / Q000502:physiology
D009569:Nitric Oxide; C002385:linsidomine; D008981:Molsidomine; D006152:Cyclic GMP; D003545:Cysteine; D012977:Sodium Nitrite; D000109:Acetylcholine