[Ultraviolet A radiation and the skin. Implications of activated forms of oxygen. Current trends and newest results].
Involvement of activated oxygen species in the responses of skin to solar ultraviolet radiations, especially ultraviolet A radiations, is being addressed by an increasing number of studies. The aim of this review is to outline the concept of "photooxidative stress". The various activated oxygen species, mechanisms involved in their formation, potential cellular targets, and cell defense mechanisms are discussed. Recently published findings are briefly described to illustrate this fast developing line of research.
Morlière
P
P
Laboratoire de Dermatologie, INSERM U.312, Hpital Henri-Mondor, Créteil, France.
Moysan
A
A
Gaboriau
F
F
Santus
R
R
Mazière
J C
JC
Dubertret
L
L
D004247:DNA / Q000528:radiation effects; D004260:DNA Repair / Q000502:physiology; D005979:Glutathione Peroxidase / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000502:physiology; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D009381:Neoplasms, Radiation-Induced / Q000503:physiopathology; D011166:Porphyrins / Q000502:physiology; D012867:Skin / Q000528:radiation effects*; D012878:Skin Neoplasms / Q000503:physiopathology; D012879:Skin Physiological Phenomena; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism; D014466:Ultraviolet Rays
D006360:Heat-Shock Proteins; D011166:Porphyrins; D013481:Superoxides; D004247:DNA; D006861:Hydrogen Peroxide; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase
Ultraviolet A et peau. Implications d'espèces activées de l'oxygène. Tendances actuelles et résultats récents.