[The ultrastructural changes in the hemato-encephalic barrier in the neocortex of rat progeny with prenatal exposures to desoxycorticosterone acetate].
Electron microscopic methods were used to study the antero-parietal area of the cortex of newborn rats from intact mothers (I group) and rats born after intramuscular injection of desoxycorticosterone acetate (DOCA) to pregnant rats during the III trimester (II group) in dose 10 mkg/100 g of the body mass or during the II-III trimester of gestation (III group) in dose of 2 mkg/100 g. By the moment of delivery the hormone dose in the both experimental groups was gradually decreased up to 0.8 mkg/100 g of the body mass. Prenatal treatment by DOCA resulted in the following changes in the structure of hematoencephalic barrier: ultrastructural changes of endotheliocytes and pericytes showing accelerated synthetic and metabolic processes; lengthening of interendotheliocytic dense junctions, increase of the amount of astroblast peduncles; accelerated development of the basement membrane (lengthening and thickening) and differentiation of astroblasts. Signs of accelerated differentiation of glioblasts and vascular wall were much more pronounced in the neocortex of the III group of animals. However, part of the vessels were surrounded by edema. The perivascular edema was accompanied by loosening of the basement membrane, flattening of endotheliocytes, pericytes and increase of their electron density.
Iurina
N A
NA
Pavlova
I G
IG
D000818:Animals; D000831:Animals, Newborn; D001812:Blood-Brain Barrier / Q000187:drug effects*; D002196:Capillaries / Q000187:drug effects / Q000648:ultrastructure; D002540:Cerebral Cortex / Q000098:blood supply / Q000187:drug effects* / Q000648:ultrastructure; D003900:Desoxycorticosterone / Q000494:pharmacology*; D005260:Female; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats
D003900:Desoxycorticosterone
Ul'trastrukturnye izmeneniia gematoéntsefalicheskogo bar'era v neokortekse potomstva krys pri prenatal'nykh vozdeĭstviiakh dezoksikortikosteron-atsetata.