Anti-HIV-I activity of linked lexitropsins.
Five groups of lexitropsin oligopeptides have been synthesized that are structurally related to the natural antiviral agents netropsin and distamycin and bearing two such moieties joined by flexible or rigid linkers. Inhibitory activity of these types of agents against murine leukemia retrovirus (MuLV) led to an evaluation of their inhibition of HIV-I in cell culture. The antiretroviral activity of the five different classes of lexitropsins is discussed in terms of their structural differences.
Wang
W
W
Department of Chemistry, University of Alberta, Edmonton, Canada.
Lown
J W
JW
D000998:Antiviral Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D002478:Cells, Cultured; D004279:DNA, Viral / Q000378:metabolism; D015195:Drug Design; D015497:HIV-1 / Q000187:drug effects*; D008979:Moloney murine leukemia virus / Q000187:drug effects; D009429:Netropsin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D013329:Structure-Activity Relationship; D010948:Viral Plaque Assay
D000998:Antiviral Agents; D004279:DNA, Viral; C053654:lexitropsin; D009429:Netropsin