Human papillomavirus-associated lesions of the vagina and cervix. Treatment with a laser and topical 5-fluorouracil.
Twenty women with cervical and vaginal human papillomavirus-associated lesions were treated with CO2 laser ablation followed by eight weekly applications of 5-fluorouracil. Viral subtyping in a majority of patients and histology were obtained before and after treatment. After treatment 88% (15 of 17) had normal vaginal biopsies, and 59% (10 of 17) had normal cervical biopsies. There were no treatment failures with subtype 6/11 infection of the cervix or vagina. All the failures were with viral subtypes 16/18 and 31/35/51. The protocol was effective in treating patients with cervical and vaginal human papillomavirus-associated lesions.
Brodman
M
M
Department of Obstetrics, Gynecology and Reproductive Sciences, Mount Sinai School of Medicine, New York, New York 10029.
Dottino
P
P
Friedman
F
F
Heller
D
D
Bleiweiss
I
I
Sperling
R
R
D000287:Administration, Topical; D001706:Biopsy; D002985:Clinical Protocols / Q000592:standards; D003131:Combined Modality Therapy; D004247:DNA; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D053685:Laser Therapy / Q000379:methods / Q000592:standards*; D009693:Nucleic Acid Hybridization; D027383:Papillomaviridae; D016896:Treatment Outcome; D014412:Tumor Virus Infections / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D002577:Uterine Cervical Diseases / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D014623:Vaginal Diseases / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*
D004247:DNA; D005472:Fluorouracil