title: The dioxin and peroxisome proliferator-activated receptors: nuclear receptors in search of endogenous ligands.
abstract: Dioxins and peroxisome proliferators represent two diverse classes of xenobiotic compounds that induce transcription of specific genes encoding cytochrome P-450 drug-metabolizing enzymes. Signal transduction by these chemicals is mediated by two distinct nuclear receptors, one of which has recently been demonstrated to be a member of the steroid hormone receptor superfamily of ligand-activated transcription factors. However, no endogenous ligand has so far been identified for either of these nuclear receptors. Lorenz Poellinger, Martin Göttlicher and Jan-Ake Gustafsson review properties of both these xenobiotic receptor systems and discuss how the molecular details in the receptor activation pathways compare with those of nuclear hormone receptors.
authors.affiliation: Department of Medical Nutrition, Karolinska Institutet, Huddinge University Hospital, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Poellinger
authors.forename: M
authors.initials: M
authors.lastname: Göttlicher
authors.forename: J A
authors.initials: JA
authors.lastname: Gustafsson
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D008830:Microbodies / Q000187:drug effects*; D018336:Receptors, Aryl Hydrocarbon; D011955:Receptors, Drug / Q000187:drug effects*; D015262:Xenobiotics / Q000633:toxicity*
chemical_list: D008024:Ligands; D018336:Receptors, Aryl Hydrocarbon; D011955:Receptors, Drug; D015262:Xenobiotics