Oxytocin stimulates translocation of protein kinase C and induces antiviral state in human amnion cells.
Association of protein kinase C (PKC) activity to the membrane fraction was observed in oxytocin treated human amnion cells (UAC). In addition, oxytocin was shown to induce an antiviral state and to inhibit multiplication of vesicular stomatitis virus (VSV) in UAC. These observations together with earlier findings indicate that activation of inositol phospholipid breakdown with a consecutive activation of PKC is a common signal transduction pathway in interferon action and hormonal stimulation.
Markovits
A
A
Microbiological Research Group, B. Johan National Institute of Hygiene, Budapest, Hungary.
Premecz
G
G
Bagi
G
G
Földes
I
I
D000650:Amnion / Q000187:drug effects* / Q000382:microbiology; D000998:Antiviral Agents / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D003588:Cytopathogenic Effect, Viral; D005260:Female; D006801:Humans; D010121:Oxytocin / Q000494:pharmacology*; D011247:Pregnancy; D011493:Protein Kinase C / Q000187:drug effects*; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects / Q000502:physiology; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D010121:Oxytocin; D011493:Protein Kinase C