[Itraconazole action on Toxoplasma gondii].
With the purpose to increase our knowledge about the spectrum of therapeutic action of itraconazole, the activity of a new triazolic derivative against Toxoplasma gondii was studied in vivo and in vitro with the aid of an experimental infection model in mice. The trial also aimed at a possible improvement of the therapy of toxoplasmosis in regard to safety and dosing easiness. The present study has not shown significant activity of itraconazole against Toxoplasma gondii, differing from a previous observation that showed it's activity against Trypanosoma cruzi.
Jamra
L M
LM
Setor de Toxoplasmose, Instituto de Medicina Tropical de São Paulo.
Amato Neto
V
V
Braz
L M
LM
Camargo
M E
ME
D000818:Animals; D017964:Itraconazole; D007654:Ketoconazole / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D014124:Toxoplasmosis, Animal / Q000188:drug therapy*
D017964:Itraconazole; D007654:Ketoconazole
Observações relativas à ação do itraconazol sobre o Toxoplasma gondii.