Impact of chromium ions on nucleoside triphosphates and nucleic acids.
Chromatography on hydroxyapatite, polarography, and spectroscopy have been used to evaluate the interactions of Cr(III) and Cr(VI) with DNA and nucleoside triphosphates. Cr(III) catalyzes the removal of pyrophosphate from nucleoside triphosphate (NTP) molecules. It also causes extensive aggregations of DNA through DNA-DNA cross-linking. Cr(VI) does not affect the DNA structure unless reduced to lower oxidation states.
Gulanowski
B
B
Department of Basic Medical Sciences, Medical Academy, Wroclaw, Poland.
Swiatek
J
J
Kozłowski
H
H
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002417:Cattle; D002845:Chromatography; D002857:Chromium / Q000494:pharmacology*; D002942:Circular Dichroism; D003432:Cross-Linking Reagents; D004247:DNA / Q000187:drug effects* / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy; D006160:Guanosine Triphosphate / Q000378:metabolism; D009711:Nucleotides / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism; D011048:Polarography; D012996:Solutions
D003432:Cross-Linking Reagents; D009711:Nucleotides; D010710:Phosphates; D012996:Solutions; D002857:Chromium; D006160:Guanosine Triphosphate; D000255:Adenosine Triphosphate; D004247:DNA