title: The effect of the alpha 2-adrenergic agonist, guanfacin, on the energy metabolism of steers fed on low-quality-roughage diets.
abstract: The effect of the alpha 2-adrenergic agonist, guanfacin, on the energy metabolism, feed intake and live weight (LW) change of steers was studied in three experiments. In the first, the metabolic rate of twelve steers was measured after a 72 h fast. The next day, after a 96 h fast, six steers were injected intramuscularly with 15 mg guanfacin in sterile saline (9 g sodium chloride/l) and six with sterile saline alone, and metabolic rate was measured again. Treatment significantly (P less than 0.01) lowered metabolic rate by approximately 20% (53.9 v. 66.8 kJ/kg per d). In the second experiment twelve steers were fed on long-chopped, low-quality roughage (Pangola grass (Digitaria decumbens) hay) ad lib. for 6 weeks. Six steers were continuously infused through a jugular catheter with 15 mg guanfacin/d (about 40 micrograms/kg LW) in sterile saline. The other six served as controls. There was no significant effect of treatment on feed intake (g dry matter (DM)/kg LW) or the rate of LW loss. Treatment significantly (P less than 0.05) increased the retention time of fluid (17.9 v. 22.1 h) in the alimentary tract. In the final experiment twenty-three steers were divided into four treatment groups and fed on long-chopped, low-quality roughage (Pangola hay). Treated animals were continuously infused with guanfacin at the rate of 20, 40 or 80 micrograms/kg LW per d. Control steers were not infused. At the end of the 6-week feeding period metabolic rate was measured after a 72 h fast. Regardless of dose, guanfacin significantly (P less than 0.01) lowered metabolic rate.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: CSIRO Division of Tropical Animal Production, Queensland, Australia.
authors.forename: R A
authors.initials: RA
authors.lastname: Hunter
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D002417:Cattle / Q000378:metabolism*; D004043:Dietary Fiber / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004734:Energy Metabolism / Q000187:drug effects*; D005215:Fasting / Q000378:metabolism; D005247:Feeding Behavior / Q000187:drug effects*; D016316:Guanfacine / Q000494:pharmacology*; D008297:Male
chemical_list: D004043:Dietary Fiber; D016316:Guanfacine