Antibodies to hepatitis C virus in kidney transplantation.
Ninety patients on dialysis, 241 cadaveric kidney donors and 27 cadaveric kidney recipients with a follow-up of 2 years, have been investigated as for anti-HCV positivity by means of 3 tests. As for patients on dialysis and cadaveric donors, the prevalence was 32 and 4%, respectively. As for transplanted patients, it must be noted that 4 negative recipients from positive donors seroconverted, but without any change in hepatic enzymes, while in 2 or 9 anti-HCV-positive recipients, hepatic enzymes increased after transplantation. Seroconversion in patients transplanted from a negative donor was not significantly different. We conclude that, according to their experience, anti-HCV positivity in the donors is not associated with a significant risk of infection in recipients of cadaveric grafts.
Triolo
G
G
Renal Unit, I.N.R.C.A., Turin, Italy.
Squiccimarro
G
G
Baldi
M
M
Messina
M
M
Salomone
M
M
Torazza
M C
MC
Pratico
L
L
Bonino
F
F
Amoroso
A
A
Segoloni
G P
GP
D000328:Adult; D005260:Female; D016174:Hepacivirus / Q000276:immunology*; D006508:Hepatitis Antibodies / Q000097:blood*; D006526:Hepatitis C / Q000276:immunology / Q000635:transmission; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D014019:Tissue Donors
D006508:Hepatitis Antibodies