[Cortical dysplasia as an epileptogenic focus: reduced binding of 123I-iomezanil with barely perceptible 99mTc-HMPAO SPECT].
In cortical areas associated with an epileptic focus, there is, in the majority of cases, a correlation between decreased benzodiazepine (Bz) receptor binding, detectable with 123I-Iomazenil, and decreased blood flow. A patient with focal epilepsy due to a localized abnormality in cortical differentiation is presented who showed a marked focal decrease in Bz receptor binding and a normal 99mTc-HMPAO SPECT. Based on this case the relation between blood flow and Bz receptor binding in epileptic foci is discussed.
Bartenstein
P
P
Klinik und Poliklinik für Nuklearmedizin der Westfälischen Wilhelms-Universität Münster, FRG.
Lehmenkühler
C
C
Sciuk
J
J
Schuierer
G
G
D002540:Cerebral Cortex / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000378:metabolism; D004828:Epilepsies, Partial / Q000000981:diagnostic imaging / Q000209:etiology* / Q000378:metabolism; D005260:Female; D005442:Flumazenil / Q000031:analogs & derivatives*; D006801:Humans; D007457:Iodine Radioisotopes; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010091:Oximes; D011963:Receptors, GABA-A / Q000378:metabolism*; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
D007457:Iodine Radioisotopes; D015609:Organotechnetium Compounds; D010091:Oximes; D011963:Receptors, GABA-A; D019690:Technetium Tc 99m Exametazime; D005442:Flumazenil; C063038:iomazenil
Kortikale Dysplasie als epileptogener Fokus: Verminderte Bindung von 123I-Iomazenil bei unauffälliger 99mTc-HMPAO SPECT.