title: Tumor necrosis factor stimulates Na+/H+ antiporter in human fibroblasts: dissociation between intracellular alkalinization and cytokine mRNA accumulation.
abstract: Several hormones and cytokines stimulate the cellular Na+/H+ antiporter and this stimulation may be a signal transduction mechanism to mediate gene expression. We find that tumor necrosis factor rapidly stimulates both the Na+/H+ antiporter and the accumulation of mRNA coding for granulocyte-macrophage colony-stimulating factor and interleukin-6 in fibroblasts. Further experiments show that these phenomena occur independent of each other.
authors.affiliation: Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
authors.forename: Y Y
authors.initials: YY
authors.lastname: Lee
authors.forename: I
authors.initials: I
authors.lastname: Kurtz
authors.forename: K
authors.initials: K
authors.lastname: Yamato
authors.forename: Z
authors.initials: Z
authors.lastname: el-Hajjoui
authors.forename: H P
authors.initials: HP
authors.lastname: Koeffler
mesh_terms: D002352:Carrier Proteins / Q000032:analysis*; D002478:Cells, Cultured; D005347:Fibroblasts / Q000378:metabolism; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000235:genetics*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D015850:Interleukin-6 / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism*; D017923:Sodium-Hydrogen Exchangers; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
chemical_list: D002352:Carrier Proteins; D015850:Interleukin-6; D012333:RNA, Messenger; D017923:Sodium-Hydrogen Exchangers; D014409:Tumor Necrosis Factor-alpha; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D013755:Tetradecanoylphorbol Acetate