[Effect of vitamin D over-dosage on the tooth and bone development of rabbits].
The paper investigated the changes of rabbit's tooth and jaw tissues by vitamin-D poisoning experiment. The results showed the dentin, periodontium, jaw bone and long bone of rabbit were all changed. X-ray showed subperiosteum absorbation and periosteum reaction. The mineral content of the rabbit's epiphysis and long bone diaphysis in experiment group were lower than that of control group. The histopathological findings were irregular hyperplasia of dentin, arrange disturbance of periodontal fibers, absorbation of the alveolar bone and mal-ossification of long bones. The above changes were more significant during 30-45 days of rabbit poisoning, after 60 days of poisoning the above signs were gradually released.
Cai
J J
JJ
School of Dentistry, Norman Bethune University of Medical Sciences, Changchun.
D000818:Animals; D015519:Bone Density / Q000187:drug effects; D001846:Bone Development / Q000187:drug effects*; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology*; D002762:Cholecalciferol / Q000506:poisoning*; D003804:Dentin / Q000473:pathology; D062787:Drug Overdose; D007568:Jaw / Q000000981:diagnostic imaging / Q000473:pathology; D010519:Periodontium / Q000473:pathology*; D011041:Poisoning / Q000473:pathology; D011817:Rabbits; D011859:Radiography
D002762:Cholecalciferol