Role of phospholipids in BK virus infection and haemagglutination.
The role of phospholipids in BK virus infection and haemagglutination was studied by competition binding experiments and by treatment of susceptible cells with phospholipases. Phospholipids extracted from Vero cells and some commercial phospholipids showed an inhibiting activity on both BK virus infectivity and haemagglutination. The treatment of Vero cells with phospholipases affected the binding of BK virus, but the addition of phospholipids to enzyme-treated cells restored their susceptibility to both viral infectivity and haemagglutination.
Sinibaldi
L
L
Istituto Pasteur, Fondazione Cenci Bolognetti, Roma, Italy.
Goldoni
P
P
Pietropaolo
V
V
Cattani
L
L
Peluso
C
C
Di Taranto
C
C
D000818:Animals; D001739:BK Virus / Q000187:drug effects / Q000378:metabolism*; D001667:Binding, Competitive / Q000502:physiology; D004912:Erythrocytes / Q000382:microbiology; D006387:Hemagglutination, Viral / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D010739:Phospholipase D; D010741:Phospholipases A; D010743:Phospholipids / Q000502:physiology*; D011991:Receptors, Virus / Q000737:chemistry / Q000502:physiology*; D014412:Tumor Virus Infections; D014709:Vero Cells / Q000382:microbiology
D010743:Phospholipids; D011991:Receptors, Virus; D010741:Phospholipases A; D010739:Phospholipase D