title: Intubating conditions and onset of neuromuscular block of rocuronium (Org 9426); a comparison with suxamethonium.
abstract: The intubating conditions and neuromuscular blocking profile following 600 micrograms.kg-1 rocuronium (Org 9426) have been investigated in patients under various experimental conditions. They were compared with conditions following 1.5 mg.kg-1 suxamethonium, preceded by a precurarising dose (10 mg) of gallamine, and with those in a control group in the absence of a muscle relaxant. Rocuronium produced good to excellent intubating conditions at 60 as well as at 90 s after administration, even though there was only a partial blockade of the adductor pollicis muscle. Intubating conditions following suxamethonium were comparable with those after rocuronium. Half of the control patients could be intubated. The clinical duration and the recovery time of 600 micrograms.kg-1 of rocuronium were 24(4) and 9(3) min (mean(s.d.)), respectively. Rocuronium may have a major advantage over existing non-depolarising muscle relaxants due to the early presence of excellent intubating conditions. The results indicate that rocuronium may replace suxamethonium in procedures in which rapid sequence induction is required.
authors.affiliation: Research Group for Experimental Anesthesiology and Clinical Pharmacology, University of Groningen, The Netherlands.
authors.forename: A C
authors.initials: AC
authors.lastname: Huizinga
authors.forename: R H
authors.initials: RH
authors.lastname: Vandenbrom
authors.forename: J M
authors.initials: JM
authors.lastname: Wierda
authors.forename: F D
authors.initials: FD
authors.lastname: Hommes
authors.forename: P J
authors.initials: PJ
authors.lastname: Hennis
mesh_terms: D000328:Adult; D000732:Androstanols / Q000494:pharmacology*; D005260:Female; D005703:Gallamine Triethiodide / Q000494:pharmacology; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D009469:Neuromuscular Junction / Q000187:drug effects*; D000077123:Rocuronium; D013390:Succinylcholine / Q000494:pharmacology*; D013514:Surgical Procedures, Operative; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D000732:Androstanols; D009466:Neuromuscular Blocking Agents; D013390:Succinylcholine; D005703:Gallamine Triethiodide; D000077123:Rocuronium