Effect of interferon gamma on the sensitivity of bovine-papilloma-virus(BPV1)-transformed cell lines to cell-mediated cytotoxicity.
The effect of interferon gamma (IFN gamma) on the immunogenicity and immunosensitivity of mouse cell lines transformed by bovine papillomavirus type 1 (BPV1) DNA was examined in a syngeneic mouse model. The overnight incubation of BPV1-transformed cell lines with 100 IU/ml IFN gamma did not affect their ability to induce the generation of cytotoxic effector cells but it clearly increased their sensitivity to lysis by interleukin-2-induced lymphokine-activated killer (LAK) cells and by non-specific LAK-type effector cells induced by BPV-1-transformed cell lines. The treatment of two allogeneic lymphoid tumour cell lines, P815X2 and YAC-1, with IFN gamma either decreased or had no effect on their sensitivity to LAK-cell-mediated lysis.
Laatikainen
A
A
Department of Clinical Microbiology, University of Kuopio, Finland.
Schultz-Suhonen
L
L
Mäntyjärvi
R
R
D000818:Animals; D052688:Bovine papillomavirus 1; D002461:Cell Line, Transformed; D002471:Cell Transformation, Neoplastic / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D007371:Interferon-gamma / Q000494:pharmacology*; D007376:Interleukin-2 / Q000494:pharmacology; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
D007376:Interleukin-2; D007371:Interferon-gamma