[Low-molecular heparin complex formation with the blood coagulation proteins--thrombin and fibrinogen].
It has been found that low molecular heparin (LMH) forms complexes with fibrinogen and thrombin. The formation of the heparin-fibrinogen and heparin-thrombin complexes has been testified by cross-linked electrophoresis. The reaction of complex formation was carried out at variable weight ratios of the components, i.e. 1:3 and 1:6, respectively. This complex causes lysis of unstabilized clots of fibrin. All these complexes manifested a slight anticoagulative activity.
Kudriashov
B A
BA
Liapina
L A
LA
Pastorova
V E
VE
Kondashevskaia
M V
MV
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D001797:Blood Protein Electrophoresis; D005340:Fibrinogen / Q000032:analysis / Q000378:metabolism*; D005342:Fibrinolysis / Q000187:drug effects; D006495:Heparin, Low-Molecular-Weight / Q000097:blood*; D066298:In Vitro Techniques; D011485:Protein Binding; D051381:Rats; D013917:Thrombin / Q000032:analysis / Q000378:metabolism*
D006495:Heparin, Low-Molecular-Weight; D005340:Fibrinogen; D013917:Thrombin
Kompleksoobrazovanie nizkomolekuliarnogo geparina s belkami svertyvaniia krovi--trombinom i fibrinogenom.