title: Primaquine-induced superoxide production by beta-thalassemic red blood cells.
abstract: Primaquine, a prooxidant antimalarial drug, incubated with human red blood cells (RBC) induced marked superoxide generation in the cells as detected by exogenous cytochrome c reduction. In the presence of primaquine, beta-thalassemic RBC produced significantly more superoxide than normal RBC, thus reflecting the vulnerability of beta-thalassemic cells to oxidative stress.
authors.affiliation: Department of Hematology, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: L N
authors.initials: LN
authors.lastname: Grinberg
authors.forename: O
authors.initials: O
authors.lastname: Shalev
authors.forename: A
authors.initials: A
authors.lastname: Goldfarb
authors.forename: E A
authors.initials: EA
authors.lastname: Rachmilewitz
mesh_terms: D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D011319:Primaquine / Q000494:pharmacology*; D013481:Superoxides / Q000097:blood*; D013789:Thalassemia / Q000097:blood*
chemical_list: D013481:Superoxides; D011319:Primaquine