title: [Visual and computer evaluation of diazepam-induced EEG changes in epilepsy for localization of epileptogenic lesion].
abstract: Diazepam-induced EEG changes were analyzed both visually and by computer in epilepsy for localization of epileptogenic lesion. The results demonstrated that changes in beta spectral were diminished in 11/24 or 15/25 cases, but regionally increased in 3/24 or 3/25 patients overlying the epileptogenic lesion or area of EEG abnormalities. Diazepam-induced delta spectral power was usually increased (9/24), but occasionally focally reduced (3/24) over the lesion. The percentage of positive findings for localization was 38% with visual analysis and 46% with spectral analysis in beta spectral power, 38% in delta spectral power, and 67% with the analysis in combined beta with delta, and 83% with four independent tests. Spectral analysis was more sensitive than visual analysis, and it was a useful supplement to visual analysis, to general EEG evaluation, and to CT. Finally, the study emphasized that a localizing diagnosis to define the epileptogenic lesion should be based on the combination of a multitude of independent tests.
authors.affiliation: Department of Neurology, First Hospital, Chongqing University of Medical Sciences.
authors.forename: Z
authors.initials: Z
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003975:Diazepam / Q000494:pharmacology*; D004569:Electroencephalography / Q000187:drug effects*; D004827:Epilepsy / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012815:Signal Processing, Computer-Assisted
chemical_list: D003975:Diazepam