Relative role of B and T lymphocytes in pathogenesis of a murine herpes virus.
Pathogenesis of a murine herpes virus was investigated in inbred strains (BALB/c, CBA, AKR and C57BL/10) of mice. After intranasal inhalation, virus was found to replicate primarily in the lungs, followed by haematogenous spread to the target organs (adrenal glands and ganglia). AKR (H-2k) were found to be most susceptible to virus infection while CBA (H-2k) mice appeared to be relatively resistant. Infection of B-cell depleted BALB/c mice resulted in detection of lower lung virus titres in B-cell depleted animals as compared to normal intact mice. Moreover, 3 of 12 normal mice in untreated group died of virus infection while deaths did not occur in the B-cell depleted group. Results of T-cell subset depletion experiments in BALB/c mice revealed maximum mortality in the group depleted of both Lyt-2+ and L3T4+ subpopulations. Infectious virus titres were also higher in lungs of T-cell depleted animals.
Kapoor
A K
AK
Department of Pathology, Cambridge, U.K.
Nash
A A
AA
Wildy
P
P
Phelan
J
J
Henney
S
S
Rebello
P
P
Blaskovic
D
D
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D006564:Herpesviridae / Q000472:pathogenicity*; D006566:Herpesviridae Infections / Q000276:immunology*; D008212:Lymphocyte Depletion; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*