High-fiber diet and serum tricyclic antidepressant levels.
The role of dietary fiber as a cause of antidepressant malabsorption has received little attention. Three patients are described who had previously been successfully treated with tricyclic antidepressants and subsequently became refractory to treatment after commencing a high-fiber diet. Serum antidepressant levels were decreased while the patients ingested the high-fiber diets and rose when the fiber content of the diet was reduced. Clinical improvement of their depression followed the concomitant rise in serum tricyclic antidepressant levels.
Stewart
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Department of Psychiatry, University of Toronto, Canada.
D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000097:blood* / Q000627:therapeutic use; D002849:Chromatography, Gas; D003866:Depressive Disorder / Q000188:drug therapy*; D004043:Dietary Fiber / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D000929:Antidepressive Agents, Tricyclic; D004043:Dietary Fiber