[Conditioned-reflex activation of electrical self-stimulation of the brain: a model of a situational craving for narcotics].
Rats with electrodes implanted into lateral hypothalamus were trained to press a lever to obtain electrical stimulation of the brain. After elaboration of self-stimulation (SS) conditioning of morphine-induced activation of SS-response was carried out. Five pairings were performed of morphine (3 mg/kg, i.p.) administration and SS in the box with distinct environmental cues (brightness, color, floor texture, background noise). After morphine withdrawal activation of SS was reproduced after simple placing of the animal in "conditioned" chamber. This effect was naloxone-sensitive. The observed effect is considered to be the adequate model of addictive substances craving.
Bespalov
A Iu
AIu
Zvartau
E E
EE
D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D007026:Hypothalamic Area, Lateral / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009021:Morphine Dependence / Q000209:etiology / Q000503:physiopathology*; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D012653:Self Stimulation / Q000187:drug effects / Q000502:physiology*; D012684:Sensory Thresholds / Q000187:drug effects / Q000502:physiology
D009270:Naloxone
Uslovnoreflektornaia aktivatsiia élektricheskoĭ samostimuliatsii mozga: model' situatsionnogo vlecheniia k narkotiku.