title: Absence of drug interaction between temafloxacin and low dose heparin.
abstract: An open 5-day study was conducted in 12 healthy male volunteers to determine the potential for drug interaction between low dose standard heparin and temafloxacin, a new fluorinated quinolone antibiotic. Heparin 5000IU was administered subcutaneously on the morning of the first and last study days and temafloxacin 600mg was administered twice daily for 4 days. The mean change in activated factor X (antifactor Xa) concentration relative to baseline 2h after coadministration was similar to that after heparin alone. Likewise, changes in activated partial prothrombin time, prothrombin time and thrombin time were similar after either heparin alone or concomitant temafloxacin administration, indicating the absence of interaction between temafloxacin and low dose standard heparin in healthy volunteers.
authors.affiliation: Guy's Drug Research Unit, Guy's Hospital, London, England.
authors.forename: T
authors.initials: T
authors.lastname: Mant
authors.forename: P
authors.initials: P
authors.lastname: Morrison
authors.forename: E
authors.initials: E
authors.lastname: Millar
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001779:Blood Coagulation Factors / Q000032:analysis; D004347:Drug Interactions; D024841:Fluoroquinolones; D006493:Heparin / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D010976:Platelet Count / Q000187:drug effects; D015363:Quinolones / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D001779:Blood Coagulation Factors; D024841:Fluoroquinolones; D015363:Quinolones; C054745:temafloxacin; D006493:Heparin