title: [Synthesis of a new neuromuscular blocking agent, pipecuronium bromide (Arduan)].
abstract: A series of bisquaternary ammonio steroids having androstane skeleton have been prepared some of which possessed high neuromuscular blocking activity. One of the series 3 alpha, 17 beta-diacetoxy-2 beta, 16 beta-bis (4,4-dimethyl-1-piperazinyl)-5 alpha-androstane dibromide (19, pipecuronium bromide, ARDUAN) has proved to be a clinically useful agent of long duration of action without side effects. The preparation of pipecuronium bromide and its metabolites and the impurities are also described. The structure of 19 and related compounds was elucidated by spectrometric methods IR, NMR and MS.
authors.affiliation: Richter Gedeon Vegyészeti Gyár Rt., Budapest.
authors.forename: Z
authors.initials: Z
authors.lastname: Tuba
authors.forename: S
authors.initials: S
authors.lastname: Mahó
mesh_terms: D015113:Androstane-3,17-diol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D009466:Neuromuscular Blocking Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D017300:Pipecuronium; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology; D013057:Spectrum Analysis
chemical_list: D009466:Neuromuscular Blocking Agents; D010879:Piperazines; D017300:Pipecuronium; D015113:Androstane-3,17-diol
vernacular_title: Egy új neuromuszkuláris blokkoló, a pipecuronium bromid (ARDUAN) szintézise.