Detection of human herpesvirus 6 in tissues involved by sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease).
After preliminary serologic data demonstrated elevated antibody titers to human herpesvirus (HHV) 6 in patients with sinus histiocytosis with massive lymphadenopathy (SHML) or Rosai-Dorfman disease, tissues were examined from 9 patients with classical SHML to search for evidence of HHV-6 infection. Involved tissues from 7 of the 9 patients had detectable HHV-6 by in situ hybridization: Tissue from 1 had detectable Epstein-Barr virus genome but no HHV-6 and tissue from another had no detectable HHV-6 or Epstein-Barr virus. These studies suggest that HHV-6 and, to a lesser extent, Epstein-Barr virus may be involved in the etiology of SHML.
Levine
P H
PH
National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
Jahan
N
N
Murari
P
P
Manak
M
M
Jaffe
E S
ES
D000914:Antibodies, Viral / Q000097:blood; D002460:Cell Line; D015654:Herpesvirus 6, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D015618:Histiocytosis, Sinus / Q000382:microbiology*; D006801:Humans; D007124:Immunoenzyme Techniques; D009693:Nucleic Acid Hybridization
D000914:Antibodies, Viral