title: Studies on the plasma cholesterol and triacylglycerols in chronic methemoglobinemia in rats.
abstract: Plasma cholesterol and triacylglycerols were measured in rats with modelled chronic two-stage (mild and moderate) intermittent nitrite methemoglobinemia for 15 and 30 days. It was found that at the moment of methemoglobinemic peak (60 +/- 10 min) the experimental animals had mixed (hemtoxic, anemic and hypoxic) hypoxemia. The every day "pulse" decrease of the total oxygen concentration during the 30-day methemoglobinemia was accompanied with a significant rise (p < 0.05) of cholesterol concentrations in the high-density lipoproteins and the total cholesterol, as well as a decrease in the amount of triacylglycerols. These changes are considered to represent the side effects of adaptation for whose elucidation further research is needed.
authors.affiliation: University of Medicine, Department of Pathophysiology, Plovdiv, Bulgaria.
authors.forename: A
authors.initials: A
authors.lastname: Hristova
authors.forename: D
authors.initials: D
authors.lastname: Iluchev
authors.forename: V
authors.initials: V
authors.lastname: Markova
authors.forename: N
authors.initials: N
authors.lastname: Atanasov
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D002908:Chronic Disease; D004195:Disease Models, Animal; D008297:Male; D008708:Methemoglobinemia / Q000097:blood*; D010100:Oxygen / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D002784:Cholesterol; D010100:Oxygen