[Fibrinolytic complexes of low-molecular heparin and acetylsalicylic acid].
Complexes of low-molecular heparin with acetylsalicilic acid was formed in vitro when the weight ratio of components was 1:1, 1:5 and 5:1, respectively. All the complexes possessed fibrinolytic and anticoagulating activities. The complex possessed the highest activity when the ratio of heparin to acetylsalicilic acid was 5:1. This complex at a dose 1 mg/200 g of rat weight had the largest thrombolytic effect on the experimental fresh thrombus.
Kudriashov
B A
BA
Pastorova
V E
VE
Liapina
L A
LA
Kondashevskaia
M V
MV
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology / Q000627:therapeutic use; D001241:Aspirin / Q000494:pharmacology / Q000627:therapeutic use*; D001780:Blood Coagulation Tests; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D005343:Fibrinolytic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006495:Heparin, Low-Molecular-Weight / Q000494:pharmacology / Q000627:therapeutic use*; D007601:Jugular Veins; D008297:Male; D051381:Rats; D013927:Thrombosis / Q000097:blood / Q000188:drug therapy
D000925:Anticoagulants; D004338:Drug Combinations; D005343:Fibrinolytic Agents; D006495:Heparin, Low-Molecular-Weight; D001241:Aspirin
Fibrinoliticheskie kompleksy nizkomolekuliarnogo geparina s atsetilsalitsilovoĭ kislotoĭ.