Induction of a mucosal barrier to bovine herpesvirus 1 replication in cattle.
Current vaccines for human and animal herpesviruses engender an immunity that may ameliorate disease but generally fails to prevent infection, latency, reactivation from latency, or spread through a population. By administering intranasally to cattle bovine herpesvirus type 1 virion envelope proteins combined with the potent mucosal immune system adjuvant, cholera toxin B subunit, we engendered a local antibody response that acted as a barrier to infection of mucosal epithelial cells and thereby prevented viral replication, consequently precluding disease, latency, and spread.
Israel
B A
BA
Department of Veterinary Science, Unversity of Wisconsin, Madison, 53706.
Herber
R
R
Gao
Y
Y
Letchworth
G J
GJ
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D001483:Base Sequence; D002417:Cattle; D004279:DNA, Viral; D007242:Herpesvirus 1, Bovine; D007241:Infectious Bovine Rhinotracheitis / Q000276:immunology* / Q000517:prevention & control; D008969:Molecular Sequence Data; D009297:Nasal Mucosa / Q000276:immunology*; D016133:Polymerase Chain Reaction; D015531:Radioimmunoprecipitation Assay; D014611:Vaccination; D014759:Viral Envelope Proteins / Q000276:immunology*; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology; D014779:Virus Replication
D000914:Antibodies, Viral; D004279:DNA, Viral; D014759:Viral Envelope Proteins; D014765:Viral Vaccines