title: Low antibody avidity in elderly chickenpox patients.
abstract: A small outbreak of chickenpox confirmed serologically in 3 elderly patients from a geriatric home is described. Disease was probably due to exogenous reinfection, yet nevertheless the avidity of specific antibodies measured by the urea denaturation test was even lower than in primary chickenpox controls, which themselves were, as expected, significantly lower than zoster controls. In elderly individuals susceptibility to reinfection with varicella-zoster virus (VZV) with clinical manifestation such as chickenpox may well be associated with the decay of specific humoral immunity detectable by antibodies of particularly low avidity, in contrast to reactivation of latent VZV presenting clinically as zoster, which is related to deficiencies in specific cellular immunity.
authors.affiliation: Department of Virology, University of the Witwatersrand, South Africa.
authors.forename: B D
authors.initials: BD
authors.lastname: Schoub
authors.forename: N K
authors.initials: NK
authors.lastname: Blackburn
authors.forename: S
authors.initials: S
authors.lastname: Johnson
authors.forename: J M
authors.initials: JM
authors.lastname: McAnerney
authors.forename: B
authors.initials: B
authors.lastname: Miller
mesh_terms: D000368:Aged; D000375:Aging / Q000276:immunology*; D000914:Antibodies, Viral / Q000097:blood*; D000915:Antibody Affinity; D002644:Chickenpox / Q000453:epidemiology / Q000276:immunology*; D004196:Disease Outbreaks; D005260:Female; D014645:Herpesvirus 3, Human / Q000276:immunology; D006707:Homes for the Aged; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G