Delineation of the phagocyte NADPH oxidase through studies of chronic granulomatous diseases of childhood.
The phagocyte NADPH oxidase is a complex system consisting of membrane and cytosolic components that must assemble at the membrane for proper activation. Studies of patients with chronic granulomatous diseases of childhood have enabled the molecular characterization of these components, which has led to studies defining their interaction during NADPH complex assembly. Understanding NADPH oxidase assembly provides an opportunity to develop therapeutics for the regulation of this important reaction of inflammation.
Gallin
J I
JI
National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.
Leto
T L
TL
Rotrosen
D
D
Kwong
C H
CH
Malech
H L
HL
D002648:Child; D003573:Cytochrome b Group / Q000235:genetics / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D004790:Enzyme Induction; D006105:Granulomatous Disease, Chronic / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D009097:Multienzyme Complexes / Q000235:genetics / Q000378:metabolism*; D009247:NADH, NADPH Oxidoreductases / Q000235:genetics / Q000378:metabolism*; D019255:NADPH Oxidases; D009504:Neutrophils / Q000201:enzymology; D010586:Phagocytes / Q000201:enzymology*; D011499:Protein Processing, Post-Translational; D016897:Respiratory Burst; D013481:Superoxides / Q000378:metabolism
D003573:Cytochrome b Group; D008565:Membrane Proteins; D009097:Multienzyme Complexes; D013481:Superoxides; C036888:cytochrome b558; D009247:NADH, NADPH Oxidoreductases; D019255:NADPH Oxidases