Lack of association between cytomegalovirus infection, HLA matching and the vanishing bile duct syndrome after liver transplantation.
In this study we evaluated the association between cytomegalovirus infection alone or in relation to human leukocyte antigen matching and the development of vanishing bile duct syndrome, a form of chronic hepatic allograft rejection. A total of 81 consecutive liver transplant recipients were studied. Cytomegalovirus infection developed in 46 recipients (57%), and vanishing bile duct syndrome occurred in 9 recipients (11%). Cytomegalovirus infection developed in only five of the nine patients with vanishing bile duct syndrome. Univariate analysis of pretransplant recipient/donor cytomegalovirus serological tests and human leukocyte antigen typing showed they were not significant risk factors for the development of vanishing bile duct syndrome. Time-dependent analysis of cytomegalovirus infection after transplantation as a risk factor for vanishing bile duct syndrome, in a multivariate analysis with human leukocyte antigen match, showed no statistical significance. In our study, no association was found between cytomegalovirus infection alone or in relation to class I or II human leukocyte antigen match and the subsequent development of vanishing bile duct syndrome.
Paya
C V
CV
Division of Infectious Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905.
Wiesner
R H
RH
Hermans
P E
PE
Larson-Keller
J J
JJ
Ilstrup
D M
DM
Krom
R A
RA
Moore
S B
SB
Ludwig
J
J
Smith
T F
TF
D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D000704:Analysis of Variance; D001649:Bile Duct Diseases / Q000150:complications*; D003586:Cytomegalovirus Infections / Q000209:etiology / Q000276:immunology / Q000503:physiopathology*; D005260:Female; D006650:Histocompatibility Testing; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D016031:Liver Transplantation / Q000276:immunology; D008297:Male; D016016:Proportional Hazards Models; D012307:Risk Factors; D013577:Syndrome; D013997:Time Factors
D000212:Acyclovir