title: Interleukin-1 beta directly excites hypothalamic supraoptic neurons in rats in vitro.
abstract: Responses of 42 neurosecretory neurons in the supraoptic nucleus (SON) to human recombinant interleukin-1 beta (IL-1 beta) were examined during intracellular recordings in rat brain slices. IL-1 beta (10(-9)-10(-8) M) depolarized the membrane and caused increased firing in 25 neurons (59.5%). In 11 other neurons (26.6%), depolarization was also seen, followed by membrane hyperpolarization. The IL-induced depolarizing effect remained in the presence of tetrodotoxin (TTX) but was abolished by sodium salicylate. The results suggest that IL-1 beta mainly exerts a direct excitatory effect on SON neurons and further, that prostaglandins may be involved in such an effect.
authors.affiliation: Department of Physiology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan.
authors.forename: Z
authors.initials: Z
authors.lastname: Li
authors.forename: K
authors.initials: K
authors.lastname: Inenage
authors.forename: S
authors.initials: S
authors.lastname: Kawano
authors.forename: H
authors.initials: H
authors.lastname: Kannan
authors.forename: H
authors.initials: H
authors.lastname: Yamashita
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology; D004594:Electrophysiology; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012459:Salicylates / Q000494:pharmacology; D020156:Salicylic Acid; D015222:Sodium Channels / Q000187:drug effects; D013495:Supraoptic Nucleus / Q000166:cytology* / Q000187:drug effects; D013779:Tetrodotoxin / Q000494:pharmacology
chemical_list: D007375:Interleukin-1; D012459:Salicylates; D015222:Sodium Channels; D001127:Arginine Vasopressin; D013779:Tetrodotoxin; D020156:Salicylic Acid