HIV-1 ancestry primordial expansions of RRE and RRE related sequences.
The human T-lymphotropic retroviruses HTLV-I and HIV-1/-2 share a complementary patchwork homology in which the RRE regions of HIV-1 and -2 cover 78.1% of a 169 nucleotide (nt) region (PX1,2) positioned precisely between open reading frames PX I and PX II of ATLV (HTLV-I). The sequence character of the PX1,2 region is shown to be influenced by a primordial expansion, CTC2T, originating several hundred nucleotides upstream. A second primordial expansion, AGCU(U/C), is identified and shown to represent 52.1% of the HIV-1 RRE region. It is argued that prior to the present AIDS pandemic the efficiency of the rev receptor was enhanced by an ancestral recombination event.
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D001483:Base Sequence; D005075:Biological Evolution; D017977:Deltaretrovirus / Q000235:genetics; D005814:Genes, Viral / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics*; D015498:HIV-2 / Q000235:genetics; D008957:Models, Genetic; D008969:Molecular Sequence Data; D011995:Recombination, Genetic; D012689:Sequence Homology, Nucleic Acid