Effect of L(+)-tartrate on some biochemical and enzymatic parameters in normal and glycollate treated rats.
Some biochemical and enzymatic constituents were determined in the small intestinal tract tissues of normal and sodium glycollate treated adult male rats. Alterations were observed with respect to certain lipids and carbohydrate fractions in the glycollate fed rats. DNA content was also elevated in this group. The functions of the cell membrane is likely to be affected as reflected in the levels of transport ATPases and orthophospho-hydrolases. The activities of the two marker enzymes in the intestinal brush border, namely alkaline phosphatase and leucylnaphthylamidase were reduced in the glycollate administered group. Administration of L(+)-tartrate, which is a mild laxative and has a regulatory influence on oxalate metabolism, lowered the activities of Na+, K(+)- and Ca(2+)-ATPases. There was a distinct lowering in the level of acid phosphatase in the tartrate treated rats.
Selvam
G S
GS
Department of Medical Biochemistry, Dr A.L. Mudaliar Post Graduate Institute of Basic Medical Sciences, Taramani, University of Madras, India.
Subha
K
K
Varalakshmi
P
P
D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D002129:Calcium Oxalate / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D050260:Carbohydrate Metabolism; D004032:Diet; D006016:Glycolates / Q000494:pharmacology*; D007421:Intestine, Small / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D007669:Kidney Calculi / Q000139:chemically induced / Q000473:pathology; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007931:Leucyl Aminopeptidase / Q000378:metabolism; D050356:Lipid Metabolism; D008297:Male; D008871:Microvilli / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013644:Tartrates / Q000494:pharmacology*
D006016:Glycolates; D013644:Tartrates; C031149:glycolic acid; D002129:Calcium Oxalate; D007770:L-Lactate Dehydrogenase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D007931:Leucyl Aminopeptidase; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase