Somatostatin receptors in the gastrointestinal tract in health and disease.
The multiple actions of somatostatin are mediated by specific membrane-bound receptors present in all somatostatin target tissues, such as brain, pituitary, pancreas, and gastrointestinal tract. Three different types of tissues in the human gastrointestinal tract express somatostatin receptors: (1) the gastrointestinal mucosa, (2) the peripheral nervous system, and (3) the gut-associated lymphoid tissue, where the receptors are preferentially located in germinal centers. In all these cases, somatostatin binding is of high affinity and specific for bioactive somatostatin analogs. Somatostatin receptors are also expressed in pathological states, particularly in neuroendocrine tumors of the gastrointestinal tract. Ninety percent of the carcinoids and a majority of islet-cell carcinomas, including their metastases, usually have a high density of somatostatin receptors. Only 10 percent of the colorectal carcinomas and none of the exocrine pancreatic carcinomas, however, contain somatostatin receptors. The somatostatin receptors in tumors are identified with in vitro binding methods or with in vivo imaging techniques; the latter allow the precise localization of the tumors and their metastases in the patients. Since somatostatin receptors in gastroenteropancreatic tumors are functional, their identification can be used to assess the therapeutic efficacy of octreotide to inhibit excessive hormone release in the patients.
Reubi
J C
JC
Division of Cell Biology and Experimental Cancer Research, University of Berne, Switzerland.
D000818:Animals; D004064:Digestive System / Q000737:chemistry* / Q000473:pathology; D004067:Digestive System Neoplasms / Q000737:chemistry* / Q000188:drug therapy / Q000473:pathology; D005753:Gastric Mucosa / Q000737:chemistry; D006651:Histocytochemistry; D006801:Humans; D007413:Intestinal Mucosa / Q000737:chemistry; D015282:Octreotide / Q000494:pharmacology; D051381:Rats; D017481:Receptors, Somatostatin / Q000032:analysis*
D017481:Receptors, Somatostatin; D015282:Octreotide