title: Relationship between HLA I surface expression and different cytopathic effects produced after herpes simplex virus infection in vitro.
abstract: In the present study, we investigated the effects of herpes simplex virus (HSV) infection on the expression of HLA class I antigens and beta 2-microglobulin in human fibroblasts. The mRNA abundance for HLA class I was shown to be strongly reduced after infection with HSV strains either producing cell rounding or fusion from within (FFWI), however, HLA class I expression on the surface of cells is strongly reduced only after appearance of FFWI. Using a ts mutant (ts 78R) or CyA in combination with a fusion from without (FFWO) inducing strain of HSV, this loss of HLA class I antigens is assumed to be correlated to the rearrangement of the cell membrane during the fusion process itself as a late event of cytopathogenicity.
authors.affiliation: Division of Experimental Virology, Johannes Gutenberg University, Mainz, Federal Republic of Germany.
authors.forename: I
authors.initials: I
authors.lastname: Walev
authors.forename: J
authors.initials: J
authors.lastname: Kunkel
authors.forename: W
authors.initials: W
authors.lastname: Schwaeble
authors.forename: K
authors.initials: K
authors.lastname: Weise
authors.forename: D
authors.initials: D
authors.lastname: Falke
mesh_terms: D015152:Blotting, Northern; D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral / Q000235:genetics; D015870:Gene Expression; D005805:Genes, MHC Class I / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D018139:Simplexvirus / Q000235:genetics / Q000502:physiology*; D001613:beta 2-Microglobulin / Q000235:genetics*
chemical_list: D006680:HLA Antigens; D001613:beta 2-Microglobulin