[The effect of fluorocitrate on oxygen consumption and Ca2+ transport in the mitochondria of liver cells].
The effect of fluorocitrate on oxidative reactions and energy production systems of rat liver mitochondria has been studied. It was shown that oxidation of endogenous substrates and malate with pyruvate as well as the phosphorylation of the added ADP were inhibited by fluorocitrate. Inhibition of oxygen consumption by fluorocitrate induced the efflux of Ca2+ ions from mitochondria and a decrease in the Ca(2+)-accumulating capacity. The effect of fluorocitrate on Ca2+ transport in mitochondria is due to activation of the Ca-efflux pathway in those sensitive to ruthenium red.
Teplova
V V
VV
Evtodienko
Iu V
IuV
Kholmukhamedov
E L
EL
Sergeenko
N G
NG
Goncharov
N V
NV
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000187:drug effects / Q000378:metabolism; D002951:Citrates / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects; D066298:In Vitro Techniques; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats
D015220:Calcium Channels; D002951:Citrates; C007744:fluorocitrate; D002118:Calcium
Vliianie ftortsitrata na potreblenie kisloroda i transport Ca2+ v mitokhondriiakh kletok pecheni.