Molecular properties of the sodium channel: a receptor for multiple neurotoxins.
Sodium channels are the receptors for more than 10 distinct classes of biological toxins which act at five or more receptor sites. Brevetoxins and ciguatoxins act at neurotoxin receptor site 5. This receptor site is located on the alpha subunit of the sodium channel, and peptide segments in domain IV of that subunit are important in brevetoxin binding.
Catterall
W A
WA
Department of Pharmacology, University of Washington, Seattle 98195.
Trainer
V
V
Baden
D G
DG
D000818:Animals; D002922:Ciguatoxins / Q000378:metabolism / Q000494:pharmacology; D008387:Marine Toxins / Q000378:metabolism / Q000494:pharmacology; D009498:Neurotoxins / Q000378:metabolism / Q000494:pharmacology; D035964:Oxocins; D011955:Receptors, Drug / Q000737:chemistry* / Q000502:physiology; D012604:Scorpion Venoms / Q000378:metabolism; D015222:Sodium Channels / Q000737:chemistry* / Q000502:physiology; D000095702:Polyether Toxins
D002922:Ciguatoxins; D008387:Marine Toxins; D009498:Neurotoxins; D035964:Oxocins; D011955:Receptors, Drug; D012604:Scorpion Venoms; D015222:Sodium Channels; C053342:brevetoxin; D000095702:Polyether Toxins