[The effect of histamine on the levels of cyclic nucleotides in the nasal mucosa tissue of rats].
The present paper reports the effect of histamine on the levels of cyclic nucleotides in the nasal mucosa tissue of rats. The results showed that the level of cAMP was significantly lower and that of cGMP was significantly higher than those of the control after provocation with 1 mmol/L histamine. Such an effect of histamine could be blocked only by mepyramine (H1 receptor blocker) but not by cimetidine (H2 receptor blocker). Verapamil (Ca channel blocker) also showed a blocking effect on histamine-induced enhancement of the level of cGMP. It is thought that the alterations of cyclic nucleotides level in nasal mucosa tissues might constitute the molecular mechanism underlying the development of histamine-induced symptoms in case of allergic rhinitis. There is possibility that Ca channel blockers such as verapamil be included in the pharmacotherapeutic armamentarium for allergic rhinitis.
Yang
P
P
Shanxi Medical College, Taiyuan.
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology*; D008297:Male; D009297:Nasal Mucosa / Q000378:metabolism*; D011738:Pyrilamine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014700:Verapamil / Q000494:pharmacology
D006632:Histamine; D014700:Verapamil; D000242:Cyclic AMP; D006152:Cyclic GMP; D011738:Pyrilamine