Determination of disodium clodronate in bulk material and pharmaceuticals by ion chromatography with post-column derivatization.
A validated ion chromatographic method for the determination of disodium clodronate in bulk material and pharmaceuticals is described. Separations are performed on a poly(styrene-divinylbenzene) copolymer column using 40 mM nitric acid as mobile phase at a flow rate of 0.5 ml min-1. The analyte is detected by UV absorption at 300 nm after post-column derivatization with acidic iron(III) solution (0.25 ml min-1). The proposed ion chromatographic method is validated in terms of selectivity, precision, linearity, accuracy and ruggedness.
Kosonen
J P
JP
Leiras Oy, Analytical Development, Turku, Finland.
D002852:Chromatography, Ion Exchange; D004002:Clodronic Acid / Q000032:analysis* / Q000302:isolation & purification; D009566:Nitrates / Q000737:chemistry; D017942:Nitric Acid; D011137:Polystyrenes / Q000737:chemistry; D015203:Reproducibility of Results; D013056:Spectrophotometry, Ultraviolet
D009566:Nitrates; D011137:Polystyrenes; D004002:Clodronic Acid; D017942:Nitric Acid; C003771:Amberlite XAD-2 resin