title: [The significance of low levels of total proteins, albumins, globulins and complement factors in ascitic fluid and the development of spontaneous bacterial peritonitis in patients with liver cirrhosis].
abstract: Spontaneous bacterial peritonitis is one of the most common complications of ascitic fluid in patients with liver cirrhosis. The aim of this study was to investigate the role of total protein, albumin, globulin and complement ascitic fluid concentrations in development of spontaneous bacterial peritonitis in patients with liver cirrhosis. In patients with liver cirrhosis and spontaneous bacterial peritonitis (n = 8) the ascitic fluid total protein, albumin and globulin concentrations were significantly lower than in patients with sterile ascites (n = 11) (p < 0.01). The ascitic fluid complement C3 and C4 concentrations were significantly lower in patients with spontaneous bacterial peritonitis than in patients with sterile ascites (9.1 +/- 3.1 mg/dL to 22.9 +/- 17.4 mg/dL, p < 0.01; 3.8 +/- 5.9 mg/dL to 8.2 +/- 5.9 mg/dL, p < 0.01, respectively). The ascites total protein, albumin, globulin and complement concentrations in cirrhotic patients with spontaneous bacterial peritonitis were significantly lower than in patients with sterile ascites demonstrating the importance of those factors in ascitic fluid defense against secondary bacterial infection.
authors.affiliation: Odjel za gastroenterologiju i hepatologiju, Klinika za unutarnje bolesti, Opća bolnica Sveti Duh, Zagreb.
authors.forename: N
authors.initials: N
authors.lastname: Ljubicić
authors.forename: A
authors.initials: A
authors.lastname: Bilić
authors.forename: Z
authors.initials: Z
authors.lastname: Babić
authors.forename: D
authors.initials: D
authors.lastname: Roić
authors.forename: M
authors.initials: M
authors.lastname: Banić
mesh_terms: D000418:Albumins / Q000032:analysis; D001202:Ascitic Fluid / Q000737:chemistry*; D001424:Bacterial Infections / Q000150:complications* / Q000378:metabolism; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis*; D005260:Female; D005916:Globulins / Q000032:analysis; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010538:Peritonitis / Q000150:complications* / Q000378:metabolism; D011506:Proteins / Q000032:analysis*
chemical_list: D000418:Albumins; D003176:Complement C3; D003181:Complement C4; D005916:Globulins; D011506:Proteins; D003165:Complement System Proteins
vernacular_title: Znacenje snizene koncentracije ukupnih proteina, albumina, globulina i komponenti komplementa unutar asciticne tekućine u nastanku spontanog bakterijskog peritonitisa u bolesnika s cirozom jetre.