title: Cyclic AMP-dependent increase of steroidogenesis in brain cortical minces.
abstract: Rat brain cortical minces were incubated with forskolin and dibutyryl-cyclic AMP for 60 and 30 min, respectively. The concentrations of pregnenolone, progesterone and desoxycorticosterone in this preparation were significantly increased by both substances. The results indicate that, in brain tissue, steroidogenesis appears to be regulated by receptor transduction mechanisms that operate through adenylate cyclase.
authors.affiliation: Department of Experimental Medicine, University of Rome Tor Vergata, Italy.
authors.forename: M L
authors.initials: ML
authors.lastname: Barbaccia
authors.forename: G
authors.initials: G
authors.lastname: Roscetti
authors.forename: M
authors.initials: M
authors.lastname: Trabucchi
authors.forename: C
authors.initials: C
authors.lastname: Ambrosio
authors.forename: M
authors.initials: M
authors.lastname: Massotti
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism*; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000502:physiology*; D003900:Desoxycorticosterone / Q000096:biosynthesis*; D066298:In Vitro Techniques; D008297:Male; D011284:Pregnenolone / Q000096:biosynthesis*; D011374:Progesterone / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D005576:Colforsin; D003900:Desoxycorticosterone; D011374:Progesterone; D011284:Pregnenolone; D000242:Cyclic AMP