Alpha-1 anti-trypsin and CD30 expression occur in parallel in activated T cells.
We have performed an immunohistochemical study of immunoblastic T cell lymphoma and enteropathy-associated T cell lymphoma for alpha-1 anti-trypsin and CD30. Cytoplasmic staining for alpha 1 anti-trypsin is present in the malignant cells in both types of T cell neoplasm which also express CD30, a marker of lymphoid activation. Peripheral blood T lymphocytes on stimulation with mitogen also show granular cytoplasmic expression of alpha 1 anti-trypsin. Time course studies show that this parallels the expression of CD30. Alpha 1 anti-trypsin expression appears therefore to be associated with activation in T cells. Further studies of sub-fractionated T lymphocytes in vitro suggest that the expression of alpha 1 anti-trypsin on activation is not restricted to an individual lymphocyte subset.
Bashir
M S
MS
University Department of Pathology, Southampton General Hospital, UK.
Jones
D B
DB
Wright
D H
DH
D015703:Antigens, CD / Q000096:biosynthesis*; D000951:Antigens, Neoplasm / Q000096:biosynthesis*; D015870:Gene Expression; D006801:Humans; D016130:Immunophenotyping; D017730:Ki-1 Antigen; D019394:Ki-67 Antigen; D008213:Lymphocyte Activation / Q000502:physiology*; D016399:Lymphoma, T-Cell / Q000276:immunology; D009687:Nuclear Proteins / Q000096:biosynthesis; D013601:T-Lymphocytes / Q000378:metabolism*; D000515:alpha 1-Antitrypsin / Q000096:biosynthesis*
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D017730:Ki-1 Antigen; D019394:Ki-67 Antigen; D009687:Nuclear Proteins; D000515:alpha 1-Antitrypsin