Alpha 2-adrenoceptor density in forebrain areas of Zucker rats: no effect of genetic obesity or antiglucocorticoid treatment.
The density of alpha 2-adrenoceptors was determined in different forebrain regions of lean and obese Zucker rats by para-[125I]iodoclonidine ([125I]PIC) receptor autoradiography. No significant differences were observed between the Zucker phenotypes in the density of alpha 2-adrenoceptors in any brain areas examined. Four days treatment with the antiglucocorticoid mifepristone (RU 38486) did not affect [125I]PIC-binding. It is concluded that the hyperphagia and abnormal corticosterone secretion of genetically obese Zucker rats do not appear to be associated with changes in alpha 2-adrenoceptor density in brain.
Pesonen
U
U
Department of Pharmacology, University of Turku, Finland.
Miettinen
T
T
Scheinin
M
M
Koulu
M
M
D000818:Animals; D005938:Glucocorticoids / Q000037:antagonists & inhibitors*; D007457:Iodine Radioisotopes; D008297:Male; D015735:Mifepristone / Q000494:pharmacology*; D009765:Obesity / Q000235:genetics / Q000378:metabolism*; D016548:Prosencephalon / Q000737:chemistry*; D011869:Radioligand Assay; D051381:Rats; D011924:Rats, Zucker; D011942:Receptors, Adrenergic, alpha / Q000032:analysis*
D005938:Glucocorticoids; D007457:Iodine Radioisotopes; D011942:Receptors, Adrenergic, alpha; D015735:Mifepristone