Orthotopic heart transplantation: an efficient treatment in a young boy with doxorubicin-induced cardiomyopathy.
We present the case of a boy who underwent orthotopic heart transplantation at the age of 14 years because of doxorubicin-induced cardiomyopathy 9 years after treatment of a Wilms tumor of the left kidney. Three years after heart transplantation the patient enjoys a normal daily life. Invasive studies show normal cardiac hemodynamic results and in spite of previous nephrectomy and long-term cyclosporine treatment, renal function is only slightly impaired. So far no secondary neoplasia has occurred under chronic immunosuppression.
Lüthy
A
A
Division of Cardiology, University Hospital, Zurich, Switzerland.
Furrer
M
M
Waser
M
M
Maggiorini
M
M
Pluess
H J
HJ
Real
F
F
Weiss
B
B
Gallino
A
A
Turina
M
M
D000293:Adolescent; D002311:Cardiomyopathy, Dilated / Q000139:chemically induced* / Q000601:surgery; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000009:adverse effects* / Q000627:therapeutic use; D016027:Heart Transplantation; D006801:Humans; D007165:Immunosuppression Therapy; D007680:Kidney Neoplasms / Q000628:therapy; D008297:Male; D013997:Time Factors; D009396:Wilms Tumor / Q000628:therapy
D004317:Doxorubicin