Histological distribution of the interleukin-4 receptor (IL4R) within the normal and pathological synovium.
The authors sought the synovial distribution of the interleukin-4 receptor in the synovium of 3 normal subjects, 5 cases of osteoarthritis (OA) and 10 cases of rheumatoid arthritis (RA) and various other inflammatory arthritic conditions. The specific receptor for interleukin-4 was mainly found on cells around subintimal blood vessels and within lymphocytic aggregates where dendritic-like cells were strongly stained. Conversely, synovial lining cells did not express the interleukin-4 receptor. In conclusion, it is believed that the expression of interleukin-4 receptor is restricted to the early activation stage of the mononuclear cells in the pathological joint.
Demazière
A
A
University of Oxford, Nuffield Department of Pathology and Bacteriology, John Radcliffe Hospital, U.K.
Leek
R
R
Athanasou
N A
NA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D005260:Female; D006801:Humans; D015847:Interleukin-4 / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000032:analysis*; D012216:Rheumatic Diseases / Q000378:metabolism; D013582:Synovial Fluid / Q000737:chemistry*
D011956:Receptors, Cell Surface; D015847:Interleukin-4