title: Ki-1-positive large-cell anaplastic lymphoma with protean manifestations including central nervous system involvement.
abstract: A 26-year-old female with Ki-1-positive large-cell anaplastic lymphoma is reported. The neoplastic cells were phenotypically and genotypically of T cell origin. Initially, neoplastic cells invaded the skin and lymph nodes, and then invaded the sternal and vertebral bones, ribs and the iliopsoas muscle. Central nervous system (CNS) involvement with paraplegia, large tumor mass formation in her breast and pleural infiltration ensued in succession. This case illustrates the protean manifestations of Ki-1-positive large cell anaplastic lymphoma complicated with CNS involvement.
authors.affiliation: Third Department of Internal Medicine, Gumma University School of Medicine, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Tsukamoto
authors.forename: K
authors.initials: K
authors.lastname: Morita
authors.forename: T
authors.initials: T
authors.lastname: Maehara
authors.forename: M
authors.initials: M
authors.lastname: Mitsuhashi
authors.forename: M
authors.initials: M
authors.lastname: Karasawa
authors.forename: H
authors.initials: H
authors.lastname: Murakami
authors.forename: M
authors.initials: M
authors.lastname: Omine
authors.forename: T
authors.initials: T
authors.lastname: Naruse
authors.forename: H
authors.initials: H
authors.lastname: Yatabe
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000032:analysis*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001842:Bone and Bones / Q000473:pathology; D002493:Central Nervous System Diseases / Q000209:etiology*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D017730:Ki-1 Antigen; D008198:Lymph Nodes / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D009132:Muscles / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use; D012867:Skin / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D015703:Antigens, CD; D000951:Antigens, Neoplasm; D017730:Ki-1 Antigen; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone