title: Spiral modiolar vein: its importance in viral load of the inner ear.
abstract: Guinea pig-specific cytomegalovirus and Sendai virus were inoculated into the cochleas of seronegative guinea pigs to study the route of entry of cells participating in inner ear inflammation. Inflammatory cells accumulated around the spiral modiolar vein and appeared to be streaming from this vein into the scala tympani via a collecting venule. Inactivated virus inoculated into the cochlea and normal control cochlea failed to show inflammatory cell infiltrates. The spiral modiolar vein appears to play an important role in the movement of cells from the systemic circulation into the inner ear as part of the host's normal defense against invading pathogens such as viruses.
authors.affiliation: Department of Otolaryngology, Hokkaido University School of Medicine, Sapporo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Fukuda
authors.forename: J P
authors.initials: JP
authors.lastname: Harris
authors.forename: E M
authors.initials: EM
authors.lastname: Keithley
authors.forename: K
authors.initials: K
authors.lastname: Ishikawa
authors.forename: B
authors.initials: B
authors.lastname: Küçük
authors.forename: Y
authors.initials: Y
authors.lastname: Inuyama
mesh_terms: D000818:Animals; D003587:Cytomegalovirus / Q000502:physiology*; D003586:Cytomegalovirus Infections / Q000382:microbiology / Q000473:pathology; D007758:Ear, Inner / Q000098:blood supply* / Q000382:microbiology; D005260:Female; D006168:Guinea Pigs; D010033:Otitis Media / Q000382:microbiology* / Q000473:pathology; D010222:Parainfluenza Virus 1, Human / Q000502:physiology*; D018184:Paramyxoviridae Infections / Q000382:microbiology / Q000473:pathology; D012533:Scala Tympani / Q000382:microbiology / Q000473:pathology; D014680:Veins / Q000382:microbiology / Q000473:pathology