[Secretion of endogenous regulators of Na K ATPase by isolated rat duodenum in osmotic stimulation of its mucous membrane].
The experiments in vitro have shown that perfusion of the isolated duodenum cavity in rats by hypotonic (20 mosmol/l H2O) or hypertonic (500 mosmol/l H2O) solutions of NaCl and mannitol during 10 min stimulates secretion of endogenic factors (activators or inhibitors of enterocytes of Na+, K(+)-ATPase) into the serous incubation solution. Contact of the duodenum mucose surface with isotonic (300 mosmol/l H2O) solutions does not stimulate the secretion of this enzyme regulators. Endogenic substance are thermostable: they retain activity relative to Na+, K+ ATPase of enterocytes after heating (100 degrees C, 10 min duration) of serous incubation solutions.
Iaremenko
M S
MS
Prokopenko
O M
OM
Vavilova
H L
HL
Kharlamova
O M
OM
D000818:Animals; D004386:Duodenum / Q000187:drug effects* / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects / Q000502:physiology; D007038:Hypotonic Solutions; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism*; D007419:Intestinal Secretions / Q000502:physiology*; D008353:Mannitol / Q000008:administration & dosage / Q000494:pharmacology*; D008954:Models, Biological; D009994:Osmolar Concentration; D051381:Rats; D012462:Saline Solution, Hypertonic; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000502:physiology*; D013268:Stimulation, Chemical
D007038:Hypotonic Solutions; D012462:Saline Solution, Hypertonic; D008353:Mannitol; D012965:Sodium Chloride; D000254:Sodium-Potassium-Exchanging ATPase
Sekretsiia endohennykh reguliatoriv Na+, K+-ATFazy izol'ovanoiu dvanadtsaiatypaloiu kyshkoiu shchuriv pid vplyvom osmotychnoï stymuliatsiï ïï slizovoï obolochki.