Biodistribution of intravenously injected [131I]Lipiodol in rats.
Tissue distribution studies of intravenously injected [131I]Lipiodol in rats were performed, and serial whole-body autoradiograms were obtained simultaneously for seven days. Most of the radiotracer was retained in the lungs. Lung uptake reached a maximum (42.44% ID/g) at 1 day, with an effective half-life of 3.0 days. The other organs showed markedly lower uptakes (less than 0.56% ID/g). The ratio between liver and lung reached a maximum (0.01) at 3 hr and then decreased with time, precluding adequate external imaging of the liver as compared with the lung.
Seto
H
H
Department of Radiological Sciences, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Tsuji
S
S
Watanabe
N
N
Futatsuya
R
R
Nomura
K
K
Maeda
M
M
Kakishital
M
M
D000818:Animals; D001345:Autoradiography; D006207:Half-Life; D007275:Injections, Intravenous; D007413:Intestinal Mucosa / Q000378:metabolism; D007457:Iodine Radioisotopes; D007459:Iodized Oil / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000378:metabolism; D013737:Testis / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution
D007457:Iodine Radioisotopes; D007459:Iodized Oil