title: Studies of reovirus pathogenesis reveal potential sites for antiviral intervention.
abstract: Pathogenesis studies in animals can uncover details concerning viral replication, growth, and access to target organs, in vivo. This, in turn, reveals opportunities for antiviral intervention that may be otherwise missed by limiting analysis to growth of virus in tissue culture. In this report, reovirus infection of mice is used as a model. Three general aspects of reovirus behavior in mice are presented and each demonstrates a property of the virus that could easily have been missed by studies in tissue culture.
authors.affiliation: Harvard Medical School.
authors.forename: B N
authors.initials: BN
authors.lastname: Fields
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D051379:Mice; D012088:Reoviridae Infections / Q000209:etiology* / Q000628:therapy*
chemical_list: D000998:Antiviral Agents