title: Effects of inhaled alpha-emitting actinides on mouse alveolar macrophages.
abstract: The effects of inhaled alpha-emitting actinides on the alveolar macrophage (AM) population of the rodent lung are reviewed and, in particular, of the effects of 239PuO2 on murine AM. The effects discussed include changes the AM pool size, macrophage diameter, mobility, phagocytic competence, and enzyme content. Finally, similarities in the dose-response relationships for the induction of nuclear aberrations by alpha emitters and in the induction of lung tumors by the same materials are noted.
authors.affiliation: Biomedical Research Department, AEA Environment and Energy, Harwell Laboratory, Oxfordshire, UK.
authors.forename: A
authors.initials: A
authors.lastname: Morgan
authors.forename: R J
authors.initials: RJ
authors.lastname: Talbot
mesh_terms: D008671:Actinoid Series Elements / Q000494:pharmacology; D000280:Administration, Inhalation; D000818:Animals; D002452:Cell Count; D002465:Cell Movement / Q000187:drug effects; D002869:Chromosome Aberrations; D005966:Glucuronidase / Q000187:drug effects / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000187:drug effects / Q000378:metabolism; D016676:Macrophages, Alveolar / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology / Q000502:physiology; D051379:Mice; D010587:Phagocytosis / Q000187:drug effects; D011005:Plutonium / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D008671:Actinoid Series Elements; C026885:plutonium dioxide; D011005:Plutonium; D007770:L-Lactate Dehydrogenase; D005966:Glucuronidase