Response of B congenic chickens to infection with infectious bursal disease virus.
Six congenic lines of chickens that differ from the parental inbred line RPRL-15I5 for genes in the major histocompatibility (B) complex were used to study the influence of the B haplotypes on the response of chickens to infection with virulent infectious bursal disease virus (IBDV) at 1 day or 4 weeks of age, and on the antibody response to vaccination with live or inactivated oil-emulsion (OE) IBDV vaccines at 7 weeks of age. IBDV-induced immunodepression and lesions in the bursa, spleen, and thymus in chickens infected with virus at 1 day of age were of the same degree of severity, regardless of line of chickens used. The response of blood cells to the mitogens phytohemagglutinin-M and concanavalin A was elevated in chickens infected with IBDV at 1 day of age. In an experiment conducted to study the effect of the B haplotype on IBDV infection in 4-week-old chickens, B congenic line C-12 (B12B12) showed the highest susceptibility to clinical IBD, with mortality of 79%. No detectable difference in the serological response to vaccination with live or OE IBDV vaccines was noted among chickens of various congenic lines. We conclude that the B haplotypes may influence IBDV-induced mortality, but not immunodepression or severity of lesions in lymphoid organs, or the antibody response to live or OE IBDV vaccines.
Fadly
A M
AM
U.S. Department of Agriculture, Avian Disease and Oncology Laboratory, East Lansing, Michigan 48823.
Bacon
L D
LD
D000818:Animals; D002645:Chickens / Q000235:genetics* / Q000276:immunology* / Q000382:microbiology; D006239:Haplotypes / Q000235:genetics / Q000276:immunology; D007178:Inbreeding; D007243:Infectious bursal disease virus / Q000276:immunology*; D008285:Major Histocompatibility Complex / Q000235:genetics / Q000276:immunology*; D011201:Poultry Diseases / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D012088:Reoviridae Infections / Q000235:genetics / Q000276:immunology / Q000662:veterinary*; D014613:Vaccines, Attenuated / Q000276:immunology; D015164:Vaccines, Inactivated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology; D014774:Virulence
D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated; D014765:Viral Vaccines