Lack of correlation between anticardiolipin antibodies and peripheral autonomic nerve involvement in systemic lupus erythematosus.
The presence of anticardiolipin antibodies has recently been related to a clinical complex in which both central and peripheral neurologic damage is included. A series of 27 female patients affected by systemic lupus erythematosus (SLE) was tested for the presence of peripheral autonomic neuropathy and serum anticardiolipin antibody (ACA) levels were determined in each patient by ELISA. Peripheral autonomic impairment was detected in 40.7% of SLE patients and a large number (77.7%) of patients had elevated levels of ACA. No relationship was found between presence of ACA (both for IgG and IgM classes) and the autonomic neuropathy.
Magarò
M
M
Divisione di Reumatologia, Università cattolica del Sacro Cuore, Roma, Italia.
Mirone
L
L
Altomonte
L
L
Zoli
A
A
Angelosante
S
S
D000328:Adult; D000906:Antibodies / Q000097:blood*; D001342:Autonomic Nervous System Diseases / Q000209:etiology*; D002308:Cardiolipins / Q000276:immunology*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000209:etiology*
D000906:Antibodies; D002308:Cardiolipins