[Involvement of cellular immunity in pathology. Neuromalaria].
Murin Cerebral Malaria (MCM) with Plasmodium berghei ANKA and the CBA/Ca mice is the result of an immunopathological process. An overproduction of TNF is implicated in its pathogenesis. Recent datas concerning TNF production during the course of Plasmodium vinckei vinckei infection, and analysis of relationships between MCM and Experimental Allergic Encephalomyelitis (EAE) raise the hypothesis of the involvement of an auto-immune process in the murin disease. The role of cellular immunity in human cerebral malaria remains obscure. Cytokines could majore adherence of parasitized red blood cells to cerebral endothelial cells.
Canque
B
B
INSERM U313, La Pitié-Salpêtrière, Paris.
D000818:Animals; D004198:Disease Susceptibility; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D016779:Malaria, Cerebral / Q000276:immunology*; D051381:Rats; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D014409:Tumor Necrosis Factor-alpha
Incrimination de l'immunité cellulaire en pathologie. Le neuropaludisme.