Chromosomal localization of human glutamate receptor genes.
The chromosomal localization of human glutamate receptor genes (GluR1-4) has been established using PCR with DNA isolated from mapping panels of Chinese hamster-human hybrid cell lines and high-resolution fluorescent in situ suppression hybridization. This was accomplished with genomic clones containing putative human homologs of rat GluR 1-4 isolated by high-stringency screening of a cosmid library with the rat cDNAs encoding GluR1-4. The locations of GluR1-4, respectively, are 5q32-33, 4q32-33, Xq25-26, and 11q22-23. Evidence implicating glutamatergic synapses in a diversity of physiologic and pathologic processes together with concordance of the chromosomal locales and results of linkage analyses establishes GluR3 and GluR4 as candidate genes for a number of nervous system disorders including the oculocerebral-renal syndrome of Lowe and a form of manic-depressive illness.
McNamara
J O
JO
Department of Veterans Affairs Medical Center, Durham, NC.
Eubanks
J H
JH
McPherson
J D
JD
Wasmuth
J J
JJ
Evans
G A
GA
Heinemann
S F
SF
D000818:Animals; D001483:Base Sequence; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D002894:Chromosomes, Human, Pair 4; D002895:Chromosomes, Human, Pair 5; D003001:Cloning, Molecular; D003360:Cosmids; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D015723:Gene Library; D005971:Glutamates / Q000378:metabolism; D006801:Humans; D006822:Hybrid Cells / Q000502:physiology; D007621:Karyotyping; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides; D010920:Placenta / Q000502:physiology; D016133:Polymerase Chain Reaction / Q000379:methods; D011247:Pregnancy; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000235:genetics*; D014960:X Chromosome
D005971:Glutamates; D009838:Oligodeoxyribonucleotides; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; D004247:DNA