title: [Treatment with rufloxacin of complicated urinary tract infections].
abstract: Eighteen patients of either sex (14 M; 4 F), ranging in age from 23 to 79 years, with clinical diagnosis of complicated cystitis due to Rufloxacin sensitive pathogens, were enrolled. Rufloxacin was administered orally at the dosage of 400 mg/die the first day; 200 mg/die the following 6 days or more. The mean duration of treatment was 7.25 +/- 0.78 days. No concomitant antimicrobial therapy was administered during the study. At the end of therapy 5/14 evaluable patients recovered, 9/14 evaluable patients improve; 4 patients were considered by Investigator as "not evaluable". Causative pathogens were isolated in all patients and eradicated in 18 out of 18 bacteriologically evaluable patients (eradication rate = 100%). Neither reinfections nor superinfections occurred. No clinical adverse event related to study medication was reported. The results indicate that Rufloxacin at the oral dose of 200 mg/die is well tolerated and effective in the treatment of complicated cystitis.
authors.affiliation: Istituto di Clinica Urologica, Università di Trieste.
authors.forename: G
authors.initials: G
authors.lastname: Carmignani
authors.forename: M
authors.initials: M
authors.lastname: Maffezzini
authors.forename: C
authors.initials: C
authors.lastname: Monti Bragadin
authors.forename: L
authors.initials: L
authors.lastname: Samer
authors.forename: A
authors.initials: A
authors.lastname: Gusmitta
authors.forename: L
authors.initials: L
authors.lastname: Cantoni
authors.forename: G
authors.initials: G
authors.lastname: Caglio
mesh_terms: D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D003556:Cystitis / Q000150:complications / Q000188:drug therapy*; D004341:Drug Evaluation; D004927:Escherichia coli Infections / Q000188:drug therapy; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D008297:Male; D008875:Middle Aged; D015363:Quinolones / Q000627:therapeutic use*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C060328:rufloxacin
vernacular_title: Trattamento con rufloxacina di infezioni complicate delle vie urinarie.