An attempt to induce formation of antibodies against endogenous retrovirus BP 6 in syngenic rats.
An attempt was made to induce production of antibodies against C-type endogenous rat retrovirus BP 6. Syngenic Lewis rats were immunized with viable tumor cells, induced with benzo(a)pyrene, continuously producing BP 6 virus. By use of immunoblotting technique, neither short- nor long-term immunization did cause formation of any detectable amounts of antibody against structural proteins of the virus. On the other hand, in immunoblotting, antibodies arised in rats immunized with purified mouse leukemia virus have been found to cross-react with endogenous rat retrovirus.
Hlubinová
K
K
Cancer Research Institute, Slovak Academy of Sciences, Bratislava.
Kovarík
A
A
Prachar
J
J
Simkovic
D
D
Feldsamová
A
A
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D007114:Immunization; D009052:Leukemia Virus, Murine / Q000276:immunology; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D012190:Retroviridae / Q000276:immunology*
D000914:Antibodies, Viral