The influence of HLA A-B-DR matching on cytomegalovirus disease after renal transplantation. Evidence that HLA-DR7-matched recipients are more susceptible to cytomegalovirus disease.
We examined the prevalence of cytomegalovirus infectious episodes, as defined by clinical, virological, and serological criteria (i.e., CMV disease), in 660 kidney graft recipients; 109 patients (16.5%) developed the disease, and 551 did not. No significant statistical link between CMV disease prevalence and a given HLA-A, -B, or -DR allele was observed. However, patients with HLA-DR7 matched grafts were statistically more frequently found (P < 0.01) in the group of recipients who developed CMV disease as compared with the group who did not develop CMV disease. Furthermore, among patients who developed CMV disease, a significant increase of HLA-DR7 matched over DR7 mismatched patients was noted, whereas no difference between matched and mismatched recipients for the other HLA-DR alleles was found. No difference in the severity of graft failure, often observed during, or immediately after, the CMV episode, was noted between patients matched or mismatched for HLA-DR7. Our data suggest that donor/recipient matching for HLA-DR7 is associated with increased CMV disease.
Blancho
G
G
Service de Néphrologie--Immunologie Clinique, INSERM U.211, Unité de Recherche sur les Effecteurs Lymphocytaires, Plateau Technique du C.H.R., Nantes, France.
Josien
R
R
Douillard
D
D
Bignon
J D
JD
Cesbron
A
A
Soulillou
J P
JP
D000483:Alleles; D003586:Cytomegalovirus Infections / Q000453:epidemiology / Q000276:immunology*; D006084:Graft Rejection / Q000453:epidemiology; D006085:Graft Survival; D015234:HLA-A Antigens / Q000032:analysis* / Q000235:genetics; D015235:HLA-B Antigens / Q000032:analysis* / Q000235:genetics; D006684:HLA-DR Antigens / Q000032:analysis* / Q000235:genetics; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects / Q000276:immunology; D010641:Phenotype; D015995:Prevalence
D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens