4-[2-[Methyl(2-phenethyl)amino]-2-oxoethyl]-8-(phenylmethoxy)-2- naphthalenecarboxylic acid: a high affinity, competitive, orally active leukotriene B4 receptor antagonist.
Huang
F C
FC
Department of Medicinal Chemistry, Rhone-Poulenc Rorer Central Research, Collegeville, Pennsylvania 19426.
Chan
W K
WK
Warus
J D
JD
Morrissette
M M
MM
Moriarty
K J
KJ
Chang
M N
MN
Travis
J J
JJ
Mitchell
L S
LS
Nuss
G W
GW
Sutherland
C A
CA
D000284:Administration, Oral; D000818:Animals; D001667:Binding, Competitive; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D007975:Leukotriene B4 / Q000378:metabolism*; D008252:Macaca fascicularis; D009284:Naphthols / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects; D010627:Phenethylamines / Q000494:pharmacology*; D011869:Radioligand Assay; D011971:Receptors, Immunologic / Q000037:antagonists & inhibitors*; D018102:Receptors, Leukotriene B4
D009284:Naphthols; D010627:Phenethylamines; D011971:Receptors, Immunologic; D018102:Receptors, Leukotriene B4; C077720:RG 14893; D007975:Leukotriene B4