title: Lymphoma induction by human B cells in scid mice.
abstract: Lymphoma development was studied in scid mice injected i.p. with PBMC from EBV-positive donors. Most injected mice developed oligo/monoclonal B-cell tumors within 4 months after the inoculation; EBV genome was found in tumor cells. Removal of T lymphocytes from the injected cell populations prevented lymphoma development in all mice, suggesting that T-cell-derived factors are involved in the expansion of the latently EBV-infected B-cell population within the immunodeficient host.
authors.affiliation: Institute of Oncology, University of Padova, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Amadori
authors.forename: M L
authors.initials: ML
authors.lastname: Veronese
authors.forename: M R
authors.initials: MR
authors.lastname: Mazza
authors.forename: R
authors.initials: R
authors.lastname: Zamarchi
authors.forename: M
authors.initials: M
authors.lastname: Mion
authors.forename: E
authors.initials: E
authors.lastname: D'Andrea
authors.forename: C
authors.initials: C
authors.lastname: Menin
authors.forename: A
authors.initials: A
authors.lastname: Del Mistro
authors.forename: A
authors.initials: A
authors.lastname: Leszl
authors.forename: F
authors.initials: F
authors.lastname: Calderazzo
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000637:transplantation*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D016867:Immunocompromised Host; D016393:Lymphoma, B-Cell / Q000276:immunology* / Q000382:microbiology; D051379:Mice; D016513:Mice, SCID; D010641:Phenotype