Epidermal growth factor stimulates the release of GDP induced by isoproterenol from isolated liver membrane.
Epidermal growth factor (EGF) stimulated the release of GDP induced by isoproterenol from isolated liver membrane. This GDP release was not induced by EGF only. The stimulatory effect of EGF was dependent on the presence of Mg2+. These results suggests that EGF receptor indirectly couples with GS-protein.
Katoh
S
S
Department of Radiopharmacy, Tohoku College of Pharmacy, Sendai, Japan.
Iwasaki
J
J
Kohno
H
H
Ohkubo
Y
Y
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects; D004815:Epidermal Growth Factor / Q000378:metabolism / Q000494:pharmacology*; D066246:ErbB Receptors / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism; D006153:Guanosine Diphosphate / Q000378:metabolism*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008274:Magnesium / Q000494:pharmacology; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
D011943:Receptors, Adrenergic, beta; D006153:Guanosine Diphosphate; D004815:Epidermal Growth Factor; D066246:ErbB Receptors; D019204:GTP-Binding Proteins; D008274:Magnesium; D007545:Isoproterenol