title: [Changes in the calcium channel of the sarcoplasmic reticulum (the ryanodine receptor) during myocardial ischemia].
abstract: We determined 3H-ryanodine binding in isolated rat hearts subjected to aerobic perfusion or to global normothermic ischemia (10-30 min). Ischemia produced a significant reduction in the number of ryanodine binding sites, while the dissociation constant of the binding reaction was unaffected.
authors.affiliation: Istituto di Cardiologia, Università degli Studi, Pisa.
authors.forename: R
authors.initials: R
authors.lastname: Zucchi
authors.forename: S
authors.initials: S
authors.lastname: Ronca-Testoni
authors.forename: G
authors.initials: G
authors.lastname: Yu
authors.forename: P
authors.initials: P
authors.lastname: Galbani
authors.forename: G
authors.initials: G
authors.lastname: Ronca
authors.forename: M
authors.initials: M
authors.lastname: Mariani
mesh_terms: D000332:Aerobiosis; D000818:Animals; D015220:Calcium Channels / Q000378:metabolism*; D066298:In Vitro Techniques; D017202:Myocardial Ischemia / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D011950:Receptors, Cholinergic / Q000378:metabolism*; D019837:Ryanodine Receptor Calcium Release Channel; D012519:Sarcoplasmic Reticulum / Q000378:metabolism*
chemical_list: D015220:Calcium Channels; D011950:Receptors, Cholinergic; D019837:Ryanodine Receptor Calcium Release Channel
vernacular_title: Alterazione del canale del calcio del reticolo sarcoplasmatico (recettore della ryanodina) durante ischemia miocardica.