title: Presynaptic long-term changes in excitability of the corticostriatal pathway.
abstract: We employed measurements of striatal terminal excitability to monitor the presynaptic effects of tetanic stimulation of corticostriatal fibers. Cortical tetanic stimulation (CTS) initiated a long-lasting decrease in terminal excitability. With higher current CTS, a transient increase in excitability preceded the decrease. However, a long-term increase was induced (1) by a second tetanus applied during the brief elevation in excitability initiated by a previous CTS or (2) when dopamine and GABA transmission were disrupted. A long-term increase also occurred following tetanic stimulation of the striatal terminal field (STS). The direction of the long-lasting change in excitability may depend on the level of polarization of the membrane. These presynaptic mechanisms could be important for the long-term selective modification of striatal synaptic transmission.
authors.affiliation: Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla 92093-0603.
authors.forename: M
authors.initials: M
authors.lastname: Garcia-Munoz
authors.forename: S J
authors.initials: SJ
authors.lastname: Young
authors.forename: P M
authors.initials: PM
authors.lastname: Groves
mesh_terms: D000818:Animals; D001479:Basal Ganglia / Q000502:physiology; D002540:Cerebral Cortex / Q000502:physiology*; D003342:Corpus Striatum / Q000502:physiology*; D004298:Dopamine / Q000502:physiology; D004558:Electric Stimulation; D004594:Electrophysiology / Q000379:methods; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013569:Synapses / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission; D005680:gamma-Aminobutyric Acid / Q000502:physiology
chemical_list: D005680:gamma-Aminobutyric Acid; D007608:Kainic Acid; D004298:Dopamine