Pathologically and serologically different avian nephritis virus isolates implicated in etiology of baby chick nephropathy.
Three virus isolates (WG-3, -4, and -5) from chicks affected by baby chick nephropathy were orally inoculated into 1-day-old specific-pathogen-free chicks of lines PDL-1 and 15I. Additional chicks were orally inoculated with avian nephritis virus (ANV) strain G-4260. Chicks inoculated with isolates WG-3, -4, and -5 died between 2 and 6 days postinoculation (PI), with mortality ranging from 0% to 53.3%. Pathological findings in the dead chicks included nephrosis in chicks inoculated with WG-3, -4, and -5, and nephritis and visceral urate deposition in chicks inoculated with G-4260. The stability of the WG-5 isolate, as well as the size of the particles and the nucleic acid type, were also similar to those of the G-4260 strain. All of the examined chicks inoculated with WG-3, -4, and -5 had interstitial nephritis at 14 days PI. Therefore, the three virus isolates were considered to be ANV. However, there was no serological relationship between the isolates and ANV (G-4260 and M-8 strains).
Shirai
J
J
Poultry Disease Laboratory, National Institute of Animal Health, Gifu, Japan.
Tanimura
N
N
Uramoto
K
K
Narita
M
M
Nakamura
K
K
Kawamura
H
H
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002645:Chickens; D003967:Diarrhea / Q000382:microbiology / Q000662:veterinary; D004770:Enterovirus / Q000276:immunology / Q000472:pathogenicity* / Q000648:ultrastructure; D004769:Enterovirus Infections / Q000382:microbiology / Q000662:veterinary*; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000382:microbiology / Q000662:veterinary*; D008854:Microscopy, Electron; D011201:Poultry Diseases / Q000382:microbiology*; D013047:Specific Pathogen-Free Organisms
D000914:Antibodies, Viral