title: Doppler and color Doppler imaging in acute transplant failure.
abstract: Most renal transplants are lost by rejection. A method is required to identify and discriminate between this and acute tubular necrosis and cyclosporin toxicity. The sonogram of the normal renal transplant is characteristic. Early Doppler studies measuring a rise in vascular impedance in acute rejection showed a high sensitivity and specificity. This appears, at least in part, to have been due to patient selection. We conclude that Doppler studies cannot be used to differentiate between the main parenchymal causes of renal transplant failure, although it can be helpful, with other clinical information, in supporting a diagnosis and in monitoring the effects of treatment.
authors.affiliation: Department of Diagnostic Ultrasound, Freedom Fields Hospital, Plymouth, United Kingdom.
authors.forename: M
authors.initials: M
authors.lastname: Pelling
authors.forename: P A
authors.initials: PA
authors.lastname: Dubbins
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000000981:diagnostic imaging* / Q000503:physiopathology; D016572:Cyclosporine / Q000009:adverse effects; D003937:Diagnosis, Differential; D006084:Graft Rejection / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D016030:Kidney Transplantation / Q000000981:diagnostic imaging* / Q000502:physiology; D007683:Kidney Tubular Necrosis, Acute / Q000000981:diagnostic imaging; D012079:Renal Circulation; D014463:Ultrasonography
chemical_list: D016572:Cyclosporine