title: Effect of oxymetazoline nose drops on vascular permeability of the nasal mucosa in the rabbit after provocation with leukotriene B4.
abstract: The effects of oxymetazoline nose drops on the vascular permeability of the nasal mucosa in a provoked inflammatory reaction was studied in anesthetized rabbits. Vascular permeability (125I-albumin) was 53% higher in the leukotriene B4-provoked nostril (LTB4) compared with the vehicle-treated contralateral nostril (p < 0.05). The amount of secretions was, however, not different from the vehicle-treated side. The LTB4-induced increase in permeability was decreased by 22% when oxymetazoline was introduced (p < 0.05), and the amount of secretions was reduced by 22% (p < 0.01). The effect of oxymetazoline on the vascular permeability of the nasal mucosa can be attributed to a vascular constriction (decrease in blood flow) and/or a change in the permeability characteristics. The LTB4-induced increase in vascular permeability was not attenuated by the monoclonal antibody IB4 directed against the neutrophil adhesion complex CD11/CD18. The latter suggests that LTB4-induced vascular permeability does not require CD18-mediated neutrophil adherence in the nasal mucosa.
authors.affiliation: Department of Applied Mechanics and Engineering Sciences-Bioengineering, San Diego, La Jolla, Calif.
authors.forename: M
authors.initials: M
authors.lastname: Bende
authors.forename: P
authors.initials: P
authors.lastname: Hansell
authors.forename: M
authors.initials: M
authors.lastname: Intaglietta
authors.forename: K E
authors.initials: KE
authors.lastname: Arfors
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D000911:Antibodies, Monoclonal / Q000145:classification / Q000276:immunology; D002199:Capillary Permeability / Q000187:drug effects*; D007975:Leukotriene B4 / Q000008:administration & dosage / Q000276:immunology*; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects*; D009299:Nasal Provocation Tests; D010109:Oxymetazoline / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits; D012220:Rhinitis / Q000188:drug therapy / Q000209:etiology / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D007975:Leukotriene B4; D010109:Oxymetazoline