Amphetamine and haloperidol modulate preprotachykinin A mRNA expression in rat nucleus accumbens and caudate-putamen.
In situ hybridization was used to measure the effect of repeated amphetamine (1.5 mg/kg) and haloperidol (0.5 mg/kg) treatment for 7 days on the expression of preprotachykinin A (PPT-A) mRNA in rat nucleus accumbens (Acb) and caudate-putamen (CPu). Amphetamine elevated the level of PPT-A mRNA in Acb, but not in CPu. Haloperidol decreased the levels in Acb shell and CPu, but not in Acb core. Haloperidol injected together with amphetamine, prevented the amphetamine-induced increase in PPT-A mRNA expression in both Acb core and shell.
Lindefors
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Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden.
D000704:Analysis of Variance; D000818:Animals; D001345:Autoradiography; D002421:Caudate Nucleus / Q000187:drug effects / Q000502:physiology*; D003838:Deoxyadenine Nucleotides; D003913:Dextroamphetamine / Q000494:pharmacology*; D015870:Gene Expression / Q000187:drug effects; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects / Q000502:physiology*; D015345:Oligonucleotide Probes; D011498:Protein Precursors / Q000235:genetics*; D011699:Putamen / Q000187:drug effects / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013462:Sulfur Radioisotopes; D015320:Tachykinins / Q000235:genetics*
D003838:Deoxyadenine Nucleotides; D015345:Oligonucleotide Probes; D011498:Protein Precursors; D012333:RNA, Messenger; D013462:Sulfur Radioisotopes; D015320:Tachykinins; C044206:preprotachykinin; D006220:Haloperidol; C026600:2'-deoxyadenosine triphosphate; D003913:Dextroamphetamine