[Effects of injection of L-glutamate into the locus coeruleus complex area on the respiration].
Experiments were performed on 55 urethane anesthetized and flaxedil immobilized rabbits under artificial respiration. Injection of L-Glutamate into the locus coeruleus area led to a marked augmentation of respiration. This effect of L-Glutamate could be significantly attenuated or reversed by a previous injection of prazosin, yohimbine and propranolol into the NTS area. These results indicate that the neurons in the locus coeruleus are involved in the regulation of the respiration as a result of mediation by alpha and beta receptors in the NTS area.
Li
Z Y
ZY
Department of Physiology, Tongji Medical University, Wuhan.
Xia
B L
BL
Huang
C J
CJ
D000818:Animals; D005260:Female; D008125:Locus Coeruleus / Q000502:physiology*; D008297:Male; D008845:Microinjections; D011224:Prazosin / Q000494:pharmacology; D011817:Rabbits; D011942:Receptors, Adrenergic, alpha / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D012119:Respiration / Q000187:drug effects* / Q000502:physiology; D012970:Sodium Glutamate / Q000494:pharmacology*
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D012970:Sodium Glutamate; D011224:Prazosin