title: The magnetic properties and water dynamics of the red blood cell: a study by proton-NMR lineshape analysis.
abstract: The magnetic properties and water dynamics of human red blood cells were examined by analysis of the water proton spectra of suspensions of oxygenated, deoxygenated, carbon monoxide-treated, and methemoglobin-containing cells at a magnetic field strength of 7.05 T. Total lineshape analysis of spectra from deoxygenated red blood cell suspensions was performed to determine the transmembrane water exchange rate, the contribution of diffusion in local magnetic field gradients to the transverse relaxation rate, and the difference between the intra- and extracellular chemical shifts of water protons. Mathematical models are proposed to account for the dependence of the chemical shifts and linewidths of these spectra on the magnetic susceptibility or density of the cells.
authors.affiliation: Center for Non-Invasive Diagnosis, University of New Mexico School of Medicine, Albuquerque 87131.
authors.forename: C
authors.initials: C
authors.lastname: Gasparovic
authors.forename: N A
authors.initials: NA
authors.lastname: Matwiyoff
mesh_terms: D001834:Body Water / Q000737:chemistry*; D002248:Carbon Monoxide / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy; D004912:Erythrocytes / Q000737:chemistry* / Q000378:metabolism; D005110:Extracellular Space / Q000737:chemistry; D006400:Hematocrit; D006454:Hemoglobins / Q000737:chemistry; D006801:Humans; D006859:Hydrogen; D009682:Magnetic Resonance Spectroscopy; D008706:Methemoglobin / Q000032:analysis; D008954:Models, Biological; D010084:Oxidation-Reduction; D010101:Oxygen Consumption
chemical_list: D006454:Hemoglobins; D002248:Carbon Monoxide; D006859:Hydrogen; D008706:Methemoglobin