title: [Calcified bladder oat cell associated with hypercalcemia and hypophosphoremia].
abstract: Description of a 69-year old male patient presenting calcified vesical tumour which, following a pathoanatomical study was shown to be an non-differentiated oat cell carcinoma associated to transitional carcinoma and adenocarcinoma. Biochemically it presented hypercalcemia and hypophosphoremia and the electron microscope study demonstrated the presence of neurosecretion granules. The immunohistochemical techniques were negative for protein S-100 and cytokeratins, but positive for the membrane epithelial antigen and the neuro-specific enolase. The patient was treated by transurethral resection and polychemotherapy, presenting an initially favourable response but dying 18 months later after widespread metastasis. These data are in agreement with those obtained from the literature review carried out with regard to clinical picture, pathoanatomical studies, aggressiveness and overall poor prognosis with this type of tumours. In our view, the tumour's mixed composition supports an origin of pluripotential cell (steam cell). Presence of neuroendocrine syndromes associated to oat cell vesical tumours is an unusual fact related to the tumour's hormonal secretion.
authors.affiliation: Servicio de Urología, Hospital Juan Canalejo, La Coruña.
authors.forename: L
authors.initials: L
authors.lastname: Busto Castañón
authors.forename: A
authors.initials: A
authors.lastname: Sousa Escandón
authors.forename: J A
authors.initials: JA
authors.lastname: Bello Giz
authors.forename: E
authors.initials: E
authors.lastname: Vázquez Martul
authors.forename: M
authors.initials: M
authors.lastname: Menéndez Prieto
authors.forename: M
authors.initials: M
authors.lastname: González Martín
mesh_terms: D000230:Adenocarcinoma / Q000150:complications*; D000368:Aged; D002114:Calcinosis / Q000150:complications*; D018288:Carcinoma, Small Cell / Q000150:complications*; D002295:Carcinoma, Transitional Cell / Q000150:complications*; D006801:Humans; D006934:Hypercalcemia / Q000150:complications*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000150:complications*; D010710:Phosphates / Q000097:blood; D001749:Urinary Bladder Neoplasms / Q000150:complications* / Q000473:pathology
chemical_list: D010710:Phosphates
vernacular_title: Oat cell vesical calcificado asociado a hipercalcemia e hipofosforemia.