title: [Restenosis after balloon angioplasty: role of platelets, thrombosis and smooth muscle cells proliferation].
abstract: Iliac atherosclerosis was produced in 50 New Zealand rabbits and followed by balloon angioplasty (BA) for the study of the mechanism of restenosis after BA. 41 rabbits undergoing successful dilatation were randomly grouped and killed at 30 min, 24 h, one and four weeks after BA, respectively. Histomorphological results showed that platelets adhered to the angioplastic areas 30 min after BA. At 24 h, a large quantity of platelets adhered to or aggregated at the areas to form a dense carpet of platelets and large or small thrombi, even a totally obstructive luman. At the 4th week, organized mural thrombi in lumen produced restenosis. There were plenty of foam cells and less smooth muscle cells (SMCs) in the vessel wall of atherosclerotic rabbits before BA. One week after BA, SMCs proliferated increasingly and migrated into the intima from the media at the second week. At the fourth week, SMCs proliferated markedly in the intima, forming new atherosclerotic plaque, which resulted in thickening of vessel wall and restenosis of originally angioplastic sites.
authors.affiliation: Department of Internal Medicine, First Hospital, Beijing Medical University.
authors.forename: B
authors.initials: B
authors.lastname: Chen
mesh_terms: D000800:Angioplasty, Balloon; D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology / Q000628:therapy*; D001792:Blood Platelets / Q000502:physiology*; D002455:Cell Division / Q000502:physiology; D007083:Iliac Artery; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000473:pathology*; D010974:Platelet Aggregation; D011817:Rabbits; D012008:Recurrence; D013927:Thrombosis / Q000209:etiology*