Assignment of the beta-subunit of rod photoreceptor cGMP phosphodiesterase gene PDEB (homolog of the mouse rd gene) to human chromosome 4p16.
The gene encoding the beta-subunit of rod photoreceptor cGMP phosphodiesterase (gene symbol PDEB, homolog of the mouse rd gene) is mapped to human chromosome 4 using somatic cell hybrids and further localized to the chromosome band 4p16 using in situ hybridization. A mutation in the mouse gene underlies the recessive trait of retinal degeneration in the rd mouse. Thus, the human homolog is a candidate for lesions causing retinal degeneration.
Bateman
J B
JB
Vision Genetics Center, Jules Stein Eye Institute, Los Angeles, California.
Klisak
I
I
Kojis
T
T
Mohandas
T
T
Sparkes
R S
RS
Li
T S
TS
Applebury
M L
ML
Bowes
C
C
Farber
D B
DB
D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000235:genetics*; D000818:Animals; D005075:Biological Evolution; D002871:Chromosome Banding; D002894:Chromosomes, Human, Pair 4; D006801:Humans; D006822:Hybrid Cells; D046911:Macromolecular Substances; D051379:Mice; D010786:Photoreceptor Cells / Q000201:enzymology*
D046911:Macromolecular Substances; D015106:3',5'-Cyclic-GMP Phosphodiesterases