title: [Bromocriptine for macroprolactinomas. Discussion of 3 cases treated successfully].
abstract: Bromocriptine was used to treat 3 patients with prolactin secreting pituitary adenoma. Diagnosis was based on the presence of a sellar tumor over 1 cm in size at CT scanning and a serum prolactin concentration above 150 ng/ml. All patients were symptomatic from pituitary hypofunction or from tumor compression of neighboring areas. Bromocriptine was given at increasing doses up to 10 mg/day. Prolactin reached normal levels 1 to 7 months later, tumor reduction was confirmed by high resolution scanning. The mechanism of bromocriptine effect on these tumors is discussed.
authors.affiliation: Departamento de Endocrinología, Metabolismo y Nutrición, Hospital Clínico, Universidad Católica de Chile, Santiago.
authors.forename: J
authors.initials: J
authors.lastname: Sapunar
authors.forename: J M
authors.initials: JM
authors.lastname: López
authors.forename: I
authors.initials: I
authors.lastname: Huete
authors.forename: R
authors.initials: R
authors.lastname: Tagle
mesh_terms: D000328:Adult; D001971:Bromocriptine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000188:drug therapy*; D015175:Prolactinoma / Q000188:drug therapy*
chemical_list: D001971:Bromocriptine
vernacular_title: Bromocriptina en macroprolactinomas. Discusion de 3 casos tratados exitosamente.