Effect of aluminium (Al) on the brain cells of the rat.
The data on binding of Al to different brain cells, namely astrocytes, neuronal cells and synaptosomes, indicated that Al interacts more with astrocytes than with neuronal cells and synaptosomes. This was confirmed by broadening of the linewidth at half height (v 1/2 Hz) of the Al peak, and also by the extent of inhibition of membrane-bound Na+,K(+)-ATPase activity.
Rao
K S
KS
Department of Nutrition and Food Safety, Central Food Technological Research Institute, Mysore, India.
D000535:Aluminum / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001253:Astrocytes / Q000187:drug effects / Q000378:metabolism; D001665:Binding Sites; D001693:Biological Transport, Active; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D066298:In Vitro Techniques; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism
D000535:Aluminum; D000254:Sodium-Potassium-Exchanging ATPase