DNA topoisomerases.
DNA topoisomerases play an important role in regulating DNA structure, thus affecting many aspects of chromosome function inside cells. Recent progress in this field raises exciting questions regarding the distinct and critical functions of multiple topoisomerases, and the roles of DNA topoisomerases in the processes of chromosome condensation, decondensation, and segregation.
Hsieh
T S
TS
Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710.
D000970:Antineoplastic Agents / Q000494:pharmacology; D001419:Bacteria / Q000201:enzymology / Q000235:genetics; D002875:Chromosomes / Q000201:enzymology; D004264:DNA Topoisomerases, Type I / Q000235:genetics*; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D005810:Multigene Family; D059004:Topoisomerase I Inhibitors; D015003:Yeasts / Q000201:enzymology / Q000235:genetics
D000970:Antineoplastic Agents; D007527:Isoenzymes; D059004:Topoisomerase I Inhibitors; D004264:DNA Topoisomerases, Type I