Vitamin A: differentiating action on gastric cancer cells and gastric mucosal cells in elderly people.
Since RA is effective only in gastric mucosal cells but not in isolated parietal cells, it is strongly suggested that RA acts on multi-potential stem cells in the gastric mucosa, facilitating their differentiation into mature parietal cells. Moreover, although RA was very effective in newborn rats as well as in young people, responsiveness to RA is decreased in the elderly people especially with atrophic gastritis. This unresponsiveness in the elderly people might be involved in the development of gastric cancer.
Chiba
T
T
Department of Internal Medicine, Kobe University School of Medicine, Japan.
Arima
N
N
D000368:Aged; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D000242:Cyclic AMP / Q000096:biosynthesis; D004357:Drug Synergism; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects*; D006632:Histamine; D006801:Humans; D051381:Rats; D013274:Stomach Neoplasms / Q000473:pathology / Q000517:prevention & control*; D014407:Tumor Cells, Cultured; D014801:Vitamin A / Q000494:pharmacology*
D014801:Vitamin A; D006632:Histamine; D000242:Cyclic AMP