title: Expression of nerve growth factor receptor immunoreactivity in the rat choroid plexus.
abstract: The presence and localization of nerve growth factor receptors (NGFr) in the choroid plexus of the adult rat has been investigated immunohistochemically using an anti-rat NGFr monoclonal antibody (192-IgG). A moderate to strong immunoreaction was observed in the epithelial cells of the choroid plexus, whereas the choroidal blood vessels and connective tissue remained unlabelled. Moreover, no sex-differences were encountered in the NGFr immunoreaction intensity and Bouin fixative was more effective than 10% formaldehyde evidenciating the NGFr immunostain. Occasionally, ependymal cells displaying NGFr immunoreactivity were observed. Present data demonstrate that the choroid plexus of the rat contain NGFr, probably low-affinity NGFr, and suggest an involvement of NGF in the regulation of cerebrospinal fluid secretion, but the importance of these findings, if any, must be investigated in future studies.
authors.affiliation: Departamento de Morfología y Biología Celular, University of Oviedo, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Vega
authors.forename: M E
authors.initials: ME
authors.lastname: Del Valle
authors.forename: B
authors.initials: B
authors.lastname: Calzada
authors.forename: M E
authors.initials: ME
authors.lastname: Bengoechea
authors.forename: A
authors.initials: A
authors.lastname: Perez-Casas
mesh_terms: D000818:Animals; D002831:Choroid Plexus / Q000737:chemistry*; D005260:Female; D007124:Immunoenzyme Techniques; D008297:Male; D009414:Nerve Growth Factors; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000032:analysis*; D017475:Receptors, Nerve Growth Factor
chemical_list: D009414:Nerve Growth Factors; D011956:Receptors, Cell Surface; D017475:Receptors, Nerve Growth Factor