title: [Association of liver cirrhosis, hepatitis B virus infection and hepatocellular carcinoma--immunohistochemical study].
abstract: In order to assess frequency and importance of the presence of alpha fetoprotein (AFP) and AlAChy as well as hepatitis B virus (HBV) infection antigens in the tissue of hepatocellular carcinoma (HCC) and in the liver tissue outside a tumour, there have been performed retrospective light-microscopic and immunohistochemical examinations of the liver tissue in 65 cases of HCC (39 autopsy and 26 biopsy cases). The finding of AlAChy in 100% of autopsy cases of HCC and 80.7% of biopsy cases of HCC compared with the presence of AFP in 33% of autopsy and 61.5% of biopsy cases point out that AlAChy is a more sensitive marker than AFP in diagnosing HCC. The presence of HBV infection antigens in 43.5% of autopsy cases and 23.5% of biopsy cases of HCC point to an important role of HBV infection in development of HCC in the studied population.
authors.affiliation: Vojnomedicinska akademija, Institut za patologiju i sudsku medicinu.
authors.forename: S
authors.initials: S
authors.lastname: Knezević-Usaj
authors.forename: J
authors.initials: J
authors.lastname: Marković-Lipkovski
authors.forename: R
authors.initials: R
authors.lastname: Jovanović
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000737:chemistry / Q000150:complications* / Q000473:pathology; D005260:Female; D006509:Hepatitis B / Q000150:complications* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008103:Liver Cirrhosis / Q000150:complications* / Q000473:pathology; D008113:Liver Neoplasms / Q000737:chemistry / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
vernacular_title: Udruzenost ciroze jetre, hepatitis B virusne infekcije i hepatocelularnog karcinoma--imunohistohemijska ispitivanja.