Effects of wheat bran on blood and tissue hormone levels in adult female rats.
The protective effect of dietary fiber on breast cancer development might be explained by the interaction between dietary fiber and hormonal processes. We studied the effects of dietary fiber and the effects of a reduced energy intake on the exposure of mammary tissue to both estrogens and progesterone, as well as the blood plasma levels of these steroids and of LH and FSH. Adult female Fisher rats were fed ad libitum either a low-fiber diet (0.5% dietary fiber based on wheat flour) or a high-fiber diet (9.2% dietary fiber based on wheat bran). A third group was used to control for the reduced energy intake of the high-fiber group and was fed the low-fiber diet restricted. Energy intake was similar for the second and third groups. Four out of 14 rats of the high-fiber group and 4 out of 15 rats of the restricted low-fiber groups were not in cycle after seven weeks on the experimental diets, indicating that the estrous cycle was significantly affected by a reduced energy intake. Exposure of mammary tissue to estrogens did not differ among the groups, as measured by estrone, estradiol-17 beta, estriol and peroxidase activity. During the peak period, plasma LH levels were significantly higher in the high-fiber group than in the two low-fiber groups. FSH and progesterone plasma levels were unaffected by the experimental diets. It is concluded that dietary fiber affects the hormonal processes involved in breast cancer development. The increased LH levels indicate an increased estrogen production in the ad libitum high-fiber group.
Arts
C J
CJ
TNO/Toxicology and Nutrition Institute, Zeist, The Netherlands.
Thijssen
J H
JH
D000818:Animals; D001835:Body Weight; D004043:Dietary Fiber / Q000494:pharmacology*; D002149:Energy Intake; D004958:Estradiol / Q000097:blood; D004967:Estrogens / Q000378:metabolism; D004971:Estrus; D005260:Female; D006062:Gonadotropins / Q000097:blood; D006728:Hormones / Q000097:blood* / Q000378:metabolism; D011374:Progesterone / Q000097:blood / Q000378:metabolism; D051381:Rats; D011916:Rats, Inbred F344; D014908:Triticum
D004043:Dietary Fiber; D004967:Estrogens; D006062:Gonadotropins; D006728:Hormones; D011374:Progesterone; D004958:Estradiol