Evaluation of spin resonance spectroscopy of red blood cell membranes to detect malignant hyperthermia susceptibility.
We have evaluated a spin labelled electron spin resonance technique to identify malignant hyperthermia susceptible (MHS) patients. We studied 19 patients, 10 MHS and nine MHN (normal), using the standard European procedure. We were unable to obtain any evidence that this technique could be used to diagnose MH susceptibility. Furthermore, there was no significant difference in the fluidity of the red blood cell membranes between the two groups, which would have been indicative of a generalized membrane abnormality in MH.
Halsall
P J
PJ
Leeds MH Investigation Unit, University Department of Anaesthesia, St James's University Hospital.
Ellis
F R
FR
Knowles
P F
PF
D004198:Disease Susceptibility; D004578:Electron Spin Resonance Spectroscopy; D004910:Erythrocyte Membrane / Q000502:physiology*; D006221:Halothane; D006801:Humans; D008305:Malignant Hyperthermia / Q000097:blood / Q000175:diagnosis*
D006221:Halothane