[Metabolism and action mechanisms of eicosanoids and platelet-activating factor in the kidney].
Recent advances in molecular biological studies on the metabolism and action mechanisms of lipid mediators: arachidonic acid metabolites (eicosanoids) and platelet-activating factor (PAF), are reviewed, in relation to their roles in the kidney. For the last decade, almost all the enzymes involved in three major arachidonic acid metabolic pathways; cyclooxygenase, lipoxygenase and epoxygenase pathways, have been purified and almost all of their cDNA have been cloned. Recently, cDNAs encoding three receptors for lipid mediators; PAF receptor, thromboxane A2/prostaglandin (PG) H2 receptor and a subtype of PGE2 receptor; EP3, were cloned. These advances have facilitated our knowledges of the physiological, pathophysiological roles of these lipid mediators in the kidney.
Watanabe
T
T
First Department of Internal Medicine, Faculty of Medicine, University of Tokyo.
D000595:Amino Acid Sequence; D000818:Animals; D015777:Eicosanoids / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008969:Molecular Sequence Data; D010972:Platelet Activating Factor / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface / Q000502:physiology; D043562:Receptors, G-Protein-Coupled; D012079:Renal Circulation
D015777:Eicosanoids; D010972:Platelet Activating Factor; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; C039351:platelet activating factor receptor