[Effect of endothelin and endothelin-antiserum on ischemia/reperfusion injury in isolated rat hearts].
Reperfusion of isolated perfused rat hearts with 10(-9) mol/L endothelin (ET) significantly exacerbated the ischemia/reperfusion injury(I/R), in contrast, reperfusion with specific ET-antiserum dramatically alleviated myocardial I/R injury. The results suggest that ET may be an important factor, which contributes to the pathogenesis of myocardial I/R injury.
Fan
G
G
Beijing Medical University.
D000818:Animals; D000252:Calcium-Transporting ATPases / Q000187:drug effects; D016232:Endothelins / Q000276:immunology / Q000494:pharmacology*; D007106:Immune Sera; D066298:In Vitro Techniques; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D015428:Myocardial Reperfusion Injury / Q000209:etiology* / Q000517:prevention & control; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D016232:Endothelins; D007106:Immune Sera; D008315:Malondialdehyde; D007770:L-Lactate Dehydrogenase; D000252:Calcium-Transporting ATPases