title: Hypoxia in human gliomas: demonstration by PET with fluorine-18-fluoromisonidazole.
abstract: Positron emission tomography (PET) with the hypoxic-cell tracer [18F]fluoromisonidazole presents a possible means of noninvasively demonstrating tumor hypoxia. PET studies using this tracer were performed in three patients with malignant glioma, and in all patients the tumor was clearly seen at 5 min postinjection and initial tumor activity exceeded cortical activity. In one patient, there was no tumor retention of [18F] fluoromisonidazole and tumor activity fell while cortical activity increased, with the two tissues reaching equality at 40-50 min. The tumor-to-plasma ratio was 0.71 at 3 hr. The other two patients showed variable tumor retention of [18F]fluoromisonidazole, with tumor-to-plasma ratios of 1.10 and 1.49 at 2 and 3 hr. These results demonstrate the feasibility of using [18F]fluoromisonidazole PET to detect hypoxia in human gliomas in vivo. Clinical trials are needed to determine whether a relationship exists between [18F]fluoromisonidazole uptake and tumor radiation response.
authors.affiliation: Lawrence Berkeley Laboratory, University of California, Berkeley.
authors.forename: P E
authors.initials: PE
authors.lastname: Valk
authors.forename: C A
authors.initials: CA
authors.lastname: Mathis
authors.forename: M D
authors.initials: MD
authors.lastname: Prados
authors.forename: J C
authors.initials: JC
authors.lastname: Gilbert
authors.forename: T F
authors.initials: TF
authors.lastname: Budinger
mesh_terms: D000328:Adult; D001254:Astrocytoma / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000503:physiopathology; D015687:Cell Hypoxia; D005462:Fluorine Radioisotopes; D005909:Glioblastoma / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008920:Misonidazole / Q000031:analogs & derivatives*; D014055:Tomography, Emission-Computed
chemical_list: D005462:Fluorine Radioisotopes; C031843:fluoromisonidazole; D008920:Misonidazole