Effect of recombinant porcine somatotropin on energy and protein utilization by growing pigs: interaction with capacity for lean tissue growth.
Three litters of four pigs from each of four different groups were used to evaluate the effect of porcine somatotropin (pST) on growth performance, body gain composition, energy and N metabolism, and in vitro cytochrome oxydase (final enzyme of the respiratory chain) activity of tissues. The four groups included boars from a synthetic line (SG1) or the Large White breed (SG2) and barrows from the Large White breed (SG3) or crossbred between Large White and Meishan breeds (SG4). Inherent capacity for daily lean tissue growth (LTG) decreased from SG1 to SG4. Within a litter, one pig was slaughtered and dissected at the beginning of the experiment (55 kg BW) and the three others were fed the same daily supply of protein and amino acids (26 g of lysine/d) but relative daily energy levels were either 113 (without pST: E1/0), 100 (3 mg of pST/d: E2/pST) or 87 (3 mg of pST/d: E3/pST). The 100 energy level corresponded to the ad libitum intake of E2/pST pigs. Two energy and N balances were carried out in respiration chambers during the experimental period. Pigs were slaughtered and dissected at approximately 95 kg BW and composition of gain was estimated using the comparative slaughter technique. In E1/0 pigs, daily BW, lean, and N gain were affected (P less than .01) by group; 566, 471, 374, and 315 g/d of lean tissue gain in SG1, SG2, SG3, and SG4 pigs, respectively. At high ME intake (E2/pST vs E1/0), pST increased daily BW (+14%), lean (+27%), or N (+26%) gain and reduced adipose tissue (-50%) gain, but the pST effect was inversely related to LTG: for N, the improvement was 2.8, 7.1, 7.0, and 11.1 g/d in SG1, SG2, SG3, and SG4 groups, respectively. Energy restriction (E3/pST vs E2/pST) reduced (P less than .001) adipose tissue gain in all groups but did not affect lean tissue or N gains in SG1, SG2, and SG3 pigs. In the pST-treated pigs of the SG4 group, the lean tissue or N gains were reduced (P less than .01) by energy restriction. Energy restriction combined with pST treatment (E3/pST) led to negligible amounts of fat deposited (40 g/d for SG1 + SG2 + SG3 pigs) and a gain:feed ratio higher than 500 g/kg (580 in SG1 pigs). The increased heat production measured in pST-treated pigs was due to its maintenance component: 275 vs 257 kcal of ME.kg BW-.60.d-1 (P less than .01).(ABSTRACT TRUNCATED AT 400 WORDS)
Noblet
J
J
Station de Recherches Porcines, Institut National de la Recherche Agronomique, l'Hermitage, France.
Herpin
P
P
Dubois
S
S
D000273:Adipose Tissue / Q000254:growth & development; D000821:Animal Feed; D000818:Animals; D001823:Body Composition / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects; D001947:Breeding; D004044:Dietary Proteins / Q000378:metabolism*; D003576:Electron Transport Complex IV / Q000378:metabolism; D002149:Energy Intake; D004734:Energy Metabolism / Q000187:drug effects*; D013006:Growth Hormone / Q000494:pharmacology*; D008297:Male; D024510:Muscle Development; D009132:Muscles / Q000201:enzymology; D009584:Nitrogen / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D011994:Recombinant Proteins / Q000494:pharmacology; D013552:Swine / Q000254:growth & development / Q000378:metabolism*; D014781:Viscera / Q000201:enzymology / Q000254:growth & development; D015430:Weight Gain / Q000187:drug effects
D004044:Dietary Proteins; D011994:Recombinant Proteins; D013006:Growth Hormone; D003576:Electron Transport Complex IV; D009584:Nitrogen