Herpes simplex virus and human papillomavirus sites correlate with chromosomal breakpoints in human cervical carcinoma.
The distribution of 1,912 breakpoints observed in a series of 148 cervical cancers was analyzed. Fifty bands were shown to be nonrandomly involved in chromosome structural rearrangements. One hundred thirty-three breaks were noted in bands known to contain a human papillomavirus integration site, and 454 breaks were noted in bands containing a herpes simplex virus breakage site. We suggest that herpes simplex viruses and, possibly, papillomaviruses play an important role in the carcinogenesis and/or development of cytogenetic abnormalities in cervical cancers.
De Braekeleer
M
M
Department of Human Science, Universite du Quebec a Chicoutimi, Canada.
Sreekantaiah
C
C
Haas
O
O
D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002873:Chromosome Fragility; D005260:Female; D006801:Humans; D027383:Papillomaviridae / Q000235:genetics* / Q000472:pathogenicity; D018139:Simplexvirus / Q000235:genetics* / Q000472:pathogenicity; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000382:microbiology*; D016662:Virus Integration / Q000235:genetics*