Effect of vigabatrin on striatal dopamine receptors: evidence in humans for interactions of GABA and dopamine systems.
Vigabatrin is a specific gamma-aminobutyric acid transaminase inhibitor. The clinical use of this drug in the treatment of epilepsy has been sporadically linked to the development of psychosis. Using 123I-IBZM, a specific dopamine D2 receptor ligand and single photon emission tomography (SPET), one month of treatment with vigabatrin was associated with a decrease in specific binding of 123I-IBZM to D2 receptors in the left hemisphere basal ganglia. This change may provide one explanation for the development of psychosis in vulnerable patients.
Ring
H A
HA
Raymond Way Neuropsychiatry Research Group, Institute of Neurology, London, UK.
Trimble
M R
MR
Costa
D C
DC
George
M S
MS
Verhoeff
P
P
Ell
P J
PJ
D000293:Adolescent; D000328:Adult; D000614:Aminocaproates / Q000627:therapeutic use*; D000927:Anticonvulsants / Q000627:therapeutic use*; D001549:Benzamides / Q000493:pharmacokinetics; D002648:Child; D002675:Child, Preschool; D003342:Corpus Striatum / Q000187:drug effects* / Q000503:physiopathology; D004831:Epilepsies, Myoclonic / Q000188:drug therapy* / Q000503:physiopathology; D017029:Epilepsy, Complex Partial / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D008297:Male; D011759:Pyrrolidines / Q000493:pharmacokinetics; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000502:physiology; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000502:physiology; D015899:Tomography, Emission-Computed, Single-Photon; D020888:Vigabatrin
D000614:Aminocaproates; D000927:Anticonvulsants; D001549:Benzamides; D007457:Iodine Radioisotopes; D011759:Pyrrolidines; D011954:Receptors, Dopamine; D011963:Receptors, GABA-A; C055743:3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide; D020888:Vigabatrin