title: Effect of some novel ethylenediamine and ethanolamine derivatives on carrageenan-induced inflammation. Correlation with antioxidant activity and structural characteristics.
abstract: The effect of eight ethylenediamine and ethanolamine derivatives on inflammation was investigated in the carrageenan-induced rat paw edema model. The ability of these compounds to inhibit superoxide anion radical (O2-.) formation in vitro was also examined using the xanthine-xanthine oxidase system. Almost all of these substances were found to possess anti-inflammatory activity. This action can be well correlated with their reported capacity to inhibit microsomal membrane lipid peroxidation, while they demonstrated negligible effect on O2.- generation. The above actions appear to depend on some structural characteristics, particularly in the aromatic series of compounds.
authors.affiliation: Department of Pharmaceutical Chemistry, School of Pharmacy, University of Thessaloniki, Greece.
authors.forename: I
authors.initials: I
authors.lastname: Andreadou
authors.forename: E
authors.initials: E
authors.lastname: Rekka
authors.forename: V J
authors.initials: VJ
authors.lastname: Demopoulos
authors.forename: P N
authors.initials: PN
authors.lastname: Kourounakis
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology*; D002351:Carrageenan; D019856:Ethanolamine; D004983:Ethanolamines / Q000494:pharmacology*; D005029:Ethylenediamines / Q000494:pharmacology*; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D013329:Structure-Activity Relationship; D013481:Superoxides / Q000037:antagonists & inhibitors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D004983:Ethanolamines; D005029:Ethylenediamines; D013481:Superoxides; D019856:Ethanolamine; C031234:ethylenediamine; D002351:Carrageenan