title: Comparative analysis of sequence variation in gp116 and gp55 components of glycoprotein B of human cytomegalovirus.
abstract: Sequence variation in the gp116 component of cytomegalovirus envelope glycoprotein B was examined in 11 clinical strains and compared with variation in gp55. The peptide variation in gp116 was found to be strongly clustered at codons 27-67, 440-460, and to a lesser extent at codons 181-194, 311-317, and 387-397. Strains adopted one of three to four peptide configurations at these loci, usually consistent with their gp55 sequence configuration. Two instances were observed of a sequence variation arising from recombination within gB. The limited, largely group-specific nature of variation in both gp116 and gp55 facilitates functional and immunologic analyses.
authors.affiliation: Medical Services, VA Medical Center, Portland, Oregon.
authors.forename: S
authors.initials: S
authors.lastname: Chou
mesh_terms: D000595:Amino Acid Sequence; D003587:Cytomegalovirus / Q000235:genetics*; D014644:Genetic Variation; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D014759:Viral Envelope Proteins / Q000235:genetics*
chemical_list: D014759:Viral Envelope Proteins; C040495:glycoprotein B, Simplexvirus