Polyadenylic:polyuridylic acid-induced protection of BALB/c mice against acute murine cytomegalovirus infection.
Treatment of BALB/c mice with poly(A):poly(U) 18 h prior to infection with a lethal dose of murine cytomegalovirus (MCMV) increased survival. In parallel with increased survival, a 10- to 100-fold reduction of plaque-forming MCMV was found in the liver and spleen of mice 4 days post-infection with a sublethal dose of MCMV. Poly(A):poly(U) did not significantly increase natural killer cell activity or prolong the duration of elevated cytotoxic activity in infected animals. The possible role of interferon in the poly(A):poly(U)-induced protection of BALB/c mice is discussed.
Adams
A
A
Department of Medical Microbiology and Immunology, University of Minnesota, Duluth 55812.
Mohrman
M
M
Johnson
A G
AG
Morin
A
A
Deschamps de Paillette
E
E
D000818:Animals; D003586:Cytomegalovirus Infections / Q000188:drug therapy* / Q000401:mortality / Q000662:veterinary*; D007694:Killer Cells, Natural / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010529:Peritoneal Cavity / Q000382:microbiology; D011063:Poly A-U / Q000627:therapeutic use*; D016019:Survival Analysis
D011063:Poly A-U