[Paraneoplastic encephalomyelitis and Lambert-Eaton syndrome].
In two men presenting with muscle weakness and disturbances of equilibrium neurophysiological examination by repeated stimulations revealed responses suggestive of Lambert-Eaton syndrome. In the first month of the disease very high levels of anti-Hu antibody were found in the serum and CSF, betraying a malignant lesion. This was confirmed by autopsy 4 months later in one patient and by bronchial biopsy 16 months later in the other patient. Both had small-cell lung carcinoma associated with paraneoplastic encephalomyelitis.
Pou Serradell
A
A
Servei de Neurologia, Hospital del Mar, Universitat Autonoma de Barcelona, Espagne.
Fueyo
J
J
Gomez
C
C
Oliveras
C
C
Espadaler
J M
JM
Alameda
F
F
Graus
F
F
D000368:Aged; D000974:Antibodies, Antinuclear / Q000302:isolation & purification; D018288:Carcinoma, Small Cell / Q000150:complications*; D002490:Central Nervous System / Q000276:immunology / Q000473:pathology; D004679:Encephalomyelitis / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007150:Immunohistochemistry; D015624:Lambert-Eaton Myasthenic Syndrome / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000209:etiology*; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes
D000974:Antibodies, Antinuclear
Encéphalomyélite et syndrome de Lambert-Eaton paranéoplasiques.