Effect of a centrally-acting muscle relaxant, eperisone hydrochloride, on muscle sympathetic nerve activity in humans.
The sympatho-modulating effects of eperisone hydrochloride, a centrally acting muscle relaxant, on microneurographically recorded muscle sympathetic nerve activity (MSA) were analyzed in human volunteers. A single dose of 300 mg of eperisone was orally administered to 19 healthy subjects aged between 19 and 27, and effects on 1) spontaneous MSA in 30 degrees head-up tilted position, 2) resting MSA and responsiveness to standing, 3) exercise-induced enhancement of MSA were observed. Eperisone has a sympatho-suppressive action in resting skeletal muscles, but has no effect on MSA in actively contracting muscles, e.g. standing, hand-gripping. The sympatho-suppressive effect of eperisone may be related to the drug-induced increase of blood low in the resting skeletal muscles; also it may be one more mechanism through which the drug can exert its muscle relaxant action.
Iwase
S
S
Department of Autonomic and Behavioral Neurosciences, Nagoya University, Japan.
Mano
T
T
Saito
M
M
Ishida
G
G
D000328:Adult; D004311:Double-Blind Method; D004576:Electromyography / Q000295:instrumentation; D005260:Female; D006801:Humans; D007537:Isometric Contraction / Q000187:drug effects; D008297:Male; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D009129:Muscle Tonus / Q000187:drug effects; D009132:Muscles / Q000294:innervation*; D011427:Propiophenones / Q000494:pharmacology*; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation; D013564:Sympathetic Nervous System / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects; D013979:Tibial Nerve / Q000187:drug effects
D009125:Muscle Relaxants, Central; D011427:Propiophenones; C030848:eperisone