Determination of cathepsins B, H, L and kininogen in breast cancer patients.
In 20 matched pairs, an increase of all cathepsins was measured in carcinoma tissue compared with normal tissue of the same breast. On contrary, the mean value for kininogen was almost 2 fold lower than mean value determined in normal cytosols. From all proteins tested, the amount of cathepsin B correlated mostly with the degree of malignancy inside the group of invasive ductal carcinoma (n = 90, p < 0.01).
Gabrijelcic
D
D
Dept. of Biochemistry, Jozef Stefan Institute, Ljubljana, Slovenia.
Svetic
B
B
Spaić
D
D
Skrk
J
J
Budihna
J
J
Turk
V
V
D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D002401:Cathepsin B / Q000032:analysis / Q000378:metabolism*; D056655:Cathepsin H; D056668:Cathepsin L; D002403:Cathepsins / Q000032:analysis / Q000378:metabolism*; D003546:Cysteine Endopeptidases; D003600:Cytosol / Q000201:enzymology / Q000378:metabolism; D010450:Endopeptidases; D005260:Female; D006801:Humans; D007704:Kininogens / Q000032:analysis / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D012016:Reference Values
D014408:Biomarkers, Tumor; D007704:Kininogens; D002403:Cathepsins; D010450:Endopeptidases; D003546:Cysteine Endopeptidases; D002401:Cathepsin B; C534281:CTSL protein, human; D056668:Cathepsin L; C534126:CTSH protein, human; D056655:Cathepsin H