Soluble interleukin 2 receptors in patients with sarcoidosis. Possible origin.
We determined levels of soluble interleukin 2 receptors (IL-2R) in patients with sarcoidosis and further examined their origin. Thirty-nine patients with sarcoidosis and 18 healthy control subjects were studied. Soluble IL-2R levels in serum were significantly higher (p < 0.01) in sarcoidosis than in control subjects. In sarcoidosis, levels of soluble IL-2R in serum were significantly higher (p < 0.05) in patients with active disease than those with inactive disease and were significantly (p < 0.01) correlated with serum angiotensin-converting enzyme (ACE) levels. IL-2R expression on monocytes and alveolar macrophages (AMs) was significantly (p < 0.01) increased in patients with sarcoidosis as compared with control subjects. Soluble IL-2R levels in the supernatants of cultured monocytes and AMs were higher in patients with sarcoidosis than in control subjects. Those of cultured T lymphocytes obtained from peripheral blood and bronchoalveolar lavage fluid were detected in some patients with sarcoidosis, while undetected in control subjects. Furthermore, soluble IL-2R in serum was significantly correlated with soluble IL-2R in the supernatants of cultured monocytes and AMs (p < 0.01 and p < 0.05, respectively). These results demonstrate that soluble IL-2R in serum is a useful index of the disease activity of sarcoidosis and is mainly derived from monocytes and AMs.
Ina
Y
Y
Second Department of Internal Medicine, Nagoya City University Medical School, Japan.
Takada
K
K
Sato
T
T
Yamamoto
M
M
Noda
M
M
Morishita
M
M
D000328:Adult; D000368:Aged; D002478:Cells, Cultured; D003513:Cycloheximide / Q000494:pharmacology; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism; D016676:Macrophages, Alveolar / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D012507:Sarcoidosis / Q000378:metabolism*; D012995:Solubility; D013601:T-Lymphocytes / Q000378:metabolism
D015375:Receptors, Interleukin-2; D003513:Cycloheximide; D007703:Peptidyl-Dipeptidase A