title: Neurokinin concentrations in cerebrospinal fluid. A preliminary study in Parkinson's disease.
abstract: Immunoreactive neurokinin A was measured in the cerebrospinal fluid of twelve patients with Parkinson's disease and eleven normal subjects, using a sensitive and precise extraction/concentration radioimmunoassay method. The mean value obtained in Parkinson's disease patients (13.2 +/- 4.6 pmol/l) was lower than that of the controls (17.4 +/- 5.9). The tendency toward a significant decrease (p = 0.085) found in this preliminary study could indicate that neurokinin A containing neurons are involved in the pathophysiology of Parkinson's disease. In addition, the establishment of reference values for neurokinin A in cerebrospinal fluid may provide a basis for further studies of this neuropeptide in neurological disorders.
authors.affiliation: Department of Biochemistry, Valle Hebrón General Hospital, Barcelona, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Galard
authors.forename: R
authors.initials: R
authors.lastname: Catalán
authors.forename: J
authors.initials: J
authors.lastname: Montalbán
authors.forename: A
authors.initials: A
authors.lastname: Molins
authors.forename: F
authors.initials: F
authors.lastname: Miquel
authors.forename: J M
authors.initials: JM
authors.lastname: Castellanos
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015288:Neurokinin A / Q000134:cerebrospinal fluid*; D010300:Parkinson Disease / Q000134:cerebrospinal fluid*; D011863:Radioimmunoassay; D012016:Reference Values
chemical_list: D015288:Neurokinin A