title: Sequence-specific DNA recognition by basic peptides.
abstract: A chiral template with C2 symmetry has been used for modeling a dimeric interface of DNA binding protein. An oligopeptide derived from the basic region of MyoD, a recently described "helix-loop-helix" class of DNA binding protein, has been tethered to the template. Among the four models which differ in chirality and polarity with respect to the arrangement of two subunits, only one dimer model with right-handed and C-terminus to C-terminus arrangement of the peptide subunits binds DNA containing native MyoD binding sequence.
authors.affiliation: Department of Polymer Science and Engineering, Kyoto Institute of Technology, Matsugasaki, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Morii
authors.forename: M
authors.initials: M
authors.lastname: Shimomura
authors.forename: I
authors.initials: I
authors.lastname: Saito
authors.forename: H
authors.initials: H
authors.lastname: Ide
authors.forename: A
authors.initials: A
authors.lastname: Murakami
authors.forename: K
authors.initials: K
authors.lastname: Makino
mesh_terms: D004247:DNA / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D005656:Fungal Proteins / Q000737:chemistry; D009124:Muscle Proteins / Q000737:chemistry; D017570:MyoD Protein; D009842:Oligopeptides / Q000378:metabolism*; D011494:Protein Kinases / Q000737:chemistry; D029701:Saccharomyces cerevisiae Proteins; D013237:Stereoisomerism
chemical_list: D004268:DNA-Binding Proteins; D005656:Fungal Proteins; D009124:Muscle Proteins; D017570:MyoD Protein; D009842:Oligopeptides; D029701:Saccharomyces cerevisiae Proteins; D004247:DNA; D011494:Protein Kinases