Kinin receptors on asthmatic airways: functional subtyping.
Bradykinin, kallidin and [desArg9]-bradykinin are oligopeptides that may contribute as mediators in the pathogenesis of bronchial asthma by interacting with specific cell surface receptors. The structure-activity relationship of kinins within the lower airways has been investigated in 16 asthmatic subjects. The findings of the present study suggest a complex action of kinins on asthmatic airways probably involving more than one receptor subtype.
Polosa
R
R
Southampton General Hospital, England.
D001249:Asthma / Q000503:physiopathology*; D001920:Bradykinin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005541:Forced Expiratory Volume / Q000187:drug effects*; D006801:Humans; D007609:Kallidin / Q000494:pharmacology*; D018002:Receptors, Bradykinin; D017981:Receptors, Neurotransmitter / Q000145:classification / Q000187:drug effects / Q000502:physiology*; D013618:Tachyphylaxis
D018002:Receptors, Bradykinin; D017981:Receptors, Neurotransmitter; C024626:bradykinin, des-Arg(9)-; D007609:Kallidin; D001920:Bradykinin