New clues into the etiology of osteoporosis: the effects of prostaglandins (E2 and F2 alpha) on bone.
A new hypothesis is presented for the first time to explain the etiology of osteoporosis. Prostaglandins (E2 and F2 alpha) at precise concentrations, have been observed to be involved in bone formation. A close association exists between levels of prostaglandins (E2 and F2 alpha) demonstrated in the neonatal mouse leading to bone formation, with estimated prostaglandins (E2 and F2 alpha) concentrations reported in man. Several hormones (vasopressin, oxytocin, luteinizing hormone, follicle-stimulating hormone, cortisol, estradiol, and testosterone) can indirectly affect prostaglandin formation leading to reduced bone formation. The association between these hormones and prostaglandins (E2 and F2 alpha) explains the physiological mechanism whereby estradiol can be effective for the treatment of osteoporosis. This association also explains the etiology of lumbar spondylitis/spondylodynia, reasons for complaints of increased pain in wet cold weather among arthritics and a multitude of other events. Mechanisms related to this interaction between various hormones and the effect of prostaglandins (E2 and F2 alpha) on bone formation are discussed.
Golde
B
B
Bloomington Hospital, Rehabilitation Services, IN 47402.
D000818:Animals; D001846:Bone Development / Q000187:drug effects; D001862:Bone Resorption; D001842:Bone and Bones / Q000187:drug effects / Q000502:physiology*; D002116:Calcitonin / Q000502:physiology; D002762:Cholecalciferol / Q000502:physiology; D003348:Cortisone / Q000502:physiology; D015237:Dinoprost / Q000494:pharmacology / Q000502:physiology*; D015232:Dinoprostone / Q000494:pharmacology / Q000502:physiology*; D005260:Female; D006801:Humans; D008593:Menopause; D008954:Models, Biological; D010024:Osteoporosis / Q000209:etiology*; D010121:Oxytocin / Q000502:physiology; D010281:Parathyroid Hormone / Q000502:physiology; D014667:Vasopressins / Q000502:physiology
D010281:Parathyroid Hormone; D014667:Vasopressins; D002762:Cholecalciferol; D010121:Oxytocin; D002116:Calcitonin; D015237:Dinoprost; D015232:Dinoprostone; D003348:Cortisone