title: Regulation of TCR alpha and beta gene allelic exclusion during T-cell development.
abstract: Early in their development, most T cells become committed to the expression of one, and only one, TCR alpha beta combination. How do T cells achieve this TCR allelic exclusion? This article discusses the configuration and expression of TCR alpha and beta genes in mature T-cell lines and TCR alpha beta transgenic mice, and proposes three nonexclusive models to account for the significant occurrence of T cells with two productive alpha gene rearrangements.
authors.affiliation: Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, France.
authors.forename: M
authors.initials: M
authors.lastname: Malissen
authors.forename: J
authors.initials: J
authors.lastname: Trucy
authors.forename: E
authors.initials: E
authors.lastname: Jouvin-Marche
authors.forename: P A
authors.initials: PA
authors.lastname: Cazenave
authors.forename: R
authors.initials: R
authors.lastname: Scollay
authors.forename: B
authors.initials: B
authors.lastname: Malissen
mesh_terms: D000483:Alleles; D000818:Animals; D002999:Clone Cells; D004254:DNA Nucleotidyltransferases / Q000235:genetics; D005786:Gene Expression Regulation; D015332:Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor / Q000235:genetics; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*; D013601:T-Lymphocytes / Q000276:immunology*; D045567:VDJ Recombinases
chemical_list: D016693:Receptors, Antigen, T-Cell, alpha-beta; D004254:DNA Nucleotidyltransferases; D045567:VDJ Recombinases