title: Focal acantholytic dyskeratosis: a snare for the pathologist. Report of two cases associated to psoriasis and fibrous papule of the nose.
abstract: Two specimens containing clinically inapparent histologic features of acantholytic dyskeratosis (on the base of a fibrous papule of the nose and overlying a psoriatic lesion) are presented. The authors discuss the conduct to be followed by the pathologist in similar cases. The general pathologist should be well trained in dermatopathology since cutaneous biopsies account for 10 to 25% of the specimens submitted for histologic diagnosis or, even, form the major part of the workload (Berry). There is a wall between the physician who submits the skin biopsies (who may be or not a dermatologist) and the pathologist. The clinical information provided by dermatologists is scant and incomplete and physicians who are not dermatologists seldom submit any information. The histological pictures found in skin biopsies are, often, common to several nosological entities and an adequate understanding of their meaning is desirable for a thorough evaluation. We ought to assess it with the maximum scientific severity, searching to solve the puzzle without depreciating the information received. In this report the authors analyse the histopathological approach to the cutaneous lesions of two patients. They displayed the association between acantholytic dyskeratosis (AD) and another cutaneous pathology. Findings like these may obstruct the final diagnosis to be issued by the pathologist.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Pathology and Dermatology, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, UNICAMP, São Paulo, Brasil.
authors.forename: M L
authors.initials: ML
authors.lastname: Cintra
authors.forename: E M
authors.initials: EM
authors.lastname: de Souza
mesh_terms: D000051:Acantholysis / Q000473:pathology*; D000368:Aged; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D005355:Fibrosis; D006801:Humans; D007642:Keratosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009666:Nose / Q000473:pathology; D009668:Nose Diseases / Q000473:pathology*; D011565:Psoriasis / Q000473:pathology*; D012867:Skin / Q000473:pathology; D017444:Skin Diseases, Papulosquamous / Q000473:pathology*