title: Ca(2+)-transport ATPases and their regulation in muscle and brain.
abstract: Eukaryotic cells express one or more isoforms of a sarco(endo)plasmic reticulum (SERCA) and of a plasma membrane (PMCA) Ca2+ pump. Both the SERCA and PMCA gene transcripts are subject to alternative processing in a differentiation stage-dependent and tissue-dependent manner. The Ca2+ pump isoforms thus generated may present different functional properties. This is exemplified by the SERCA2a and SERCA2b isoforms which differ in their Ca2+ sensitivity. Analysis of the cDNA structures for PMCA1 predicts protein isoforms with variant calmodulin- and phospholipid-binding domains. A comparative study of the tissue-specific mechanisms governing SERCA-PMCA transcript processing and a more detailed study of the functional implication of the PMCA pumps isoform diversity will be challenging subjects for future studies.
authors.affiliation: Katholieke Universiteit Leuven, Laboratorium voor Fysiologie, Belgium.
authors.forename: F
authors.initials: F
authors.lastname: Wuytack
authors.forename: L
authors.initials: L
authors.lastname: Raeymaekers
authors.forename: H
authors.initials: H
authors.lastname: De Smedt
authors.forename: J A
authors.initials: JA
authors.lastname: Eggermont
authors.forename: L
authors.initials: L
authors.lastname: Missiaen
authors.forename: L
authors.initials: L
authors.lastname: Van Den Bosch
authors.forename: S
authors.initials: S
authors.lastname: De Jaegere
authors.forename: H
authors.initials: H
authors.lastname: Verboomen
authors.forename: L
authors.initials: L
authors.lastname: Plessers
authors.forename: R
authors.initials: R
authors.lastname: Casteels
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D001921:Brain / Q000201:enzymology*; D000252:Calcium-Transporting ATPases / Q000235:genetics* / Q000378:metabolism; D002462:Cell Membrane / Q000201:enzymology; D004721:Endoplasmic Reticulum / Q000201:enzymology; D015971:Gene Expression Regulation, Enzymologic; D005810:Multigene Family; D009132:Muscles / Q000201:enzymology*; D012519:Sarcoplasmic Reticulum / Q000201:enzymology; D014158:Transcription, Genetic
chemical_list: D000252:Calcium-Transporting ATPases