Dose-dependent vitamin D3, 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3-induced hypercalcemia and hyperphosphatemia, and the correlative changes in the activity of ultimobranchial and parathyroid glands of the toad, Bufo andersoni Boulenger.
Vitamin D3, 25(OH) vitamin D3 and 1,25 (OH)2D3 were administered daily to unfed male Bufo andersoni for 15 days which resulted in a significant hypercalcemia and hyperphosphatemia in a dose-dependent fashion. 1,25(OH)2D3 is more potent than the other metabolites. The treatment activated ultimobranchial gland but induced degenerative changes in parathyroid of the toads.
Swarup
K
K
The National Academy of Sciences, Allahabad, India.
Pandey
A K
AK
Hasan
N
N
Das
V K
VK
D000818:Animals; D002025:Bufonidae; D002112:Calcifediol / Q000494:pharmacology*; D002117:Calcitriol / Q000494:pharmacology*; D002118:Calcium / Q000097:blood; D002762:Cholecalciferol / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006934:Hypercalcemia / Q000097:blood / Q000139:chemically induced*; D008297:Male; D010280:Parathyroid Glands / Q000187:drug effects / Q000378:metabolism*; D010710:Phosphates / Q000097:blood*; D014460:Ultimobranchial Body / Q000187:drug effects / Q000378:metabolism*
D010710:Phosphates; D002762:Cholecalciferol; D002117:Calcitriol; D002112:Calcifediol; D002118:Calcium