The association of kidney graft outcome with pretransplant serum IgG-anti-F(ab')2 gamma activity.
Pretransplant sera of 474 kidney graft recipients were tested for IgG-anti-F(ab')2 gamma activity. The patients had significantly higher IgG-anti-F(ab')2 gamma activity than healthy controls (P = 0.0004). Serum lymphocytotoxic antibodies were correlated with IgG-anti-F(ab')2 gamma (P = 0.004), whereas CMV infection and blood transfusions were not. We found a significant association between pretransplant IgG-anti-F(ab')2 gamma activity and early and 1-year kidney graft outcome. This association was pronounced in recipients with no lymphocytotoxic antibodies. Recipients with immediately functioning grafts and a creatinine < 130 mumol/L at 1 year had strikingly higher pretransplant IgG-anti-F(ab')2 gamma activity than patients with graft failure (P < 0.0001).
Süsal
C
C
Department of Transplantation Immunology, University of Heidelberg, Germany.
Groth
J
J
Oberg
H H
HH
Terness
P
P
May
G
G
Opelz
G
G
D000888:Antibodies, Anti-Idiotypic / Q000032:analysis*; D000961:Antilymphocyte Serum / Q000276:immunology*; D001803:Blood Transfusion; D003586:Cytomegalovirus Infections / Q000276:immunology; D006085:Graft Survival; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000276:immunology*; D016030:Kidney Transplantation / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D000961:Antilymphocyte Serum; D007140:Immunoglobulin Fab Fragments