title: Expression of HLA-DR in intrahepatic cholangiocarcinoma.
abstract: Expression of HLA-DR was investigated immunohistochemically in 20 cases of intrahepatic cholangiocarcinoma, as well as 9 normal livers that had been obtained at autopsy. Five of the nine normal livers had peribiliary glands that showed HLA-DR. Positive staining for HLA-DR on tumor cells was observed in 6 of 13 cases of cholangiocarcinoma of the hepatic hilus and in only 1 of 7 cases of peripheral cholangiocellular carcinoma. In cholangiocarcinomas of the hepatic hilus, the 5-year survival rate for tumors that had positive staining for HLA-DR was better than that for tumors that had negative staining. Based on these results, the presence or absence of HLA-DR on tumor cells could have a pathologic significance for intrahepatic cholangiocarcinoma.
authors.affiliation: Department of Surgery II, Nagoya University, School of Medicine, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Torii
authors.forename: A
authors.initials: A
authors.lastname: Harada
authors.forename: A
authors.initials: A
authors.lastname: Nakao
authors.forename: T
authors.initials: T
authors.lastname: Nonami
authors.forename: A
authors.initials: A
authors.lastname: Nakayama
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: H
authors.initials: H
authors.lastname: Takagi
mesh_terms: D002759:Adenoma, Bile Duct / Q000276:immunology*; D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis; D001650:Bile Duct Neoplasms / Q000276:immunology*; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis*; D006500:Hepatic Duct, Common / Q000276:immunology*; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000276:immunology; D008113:Liver Neoplasms / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis
chemical_list: D000906:Antibodies; D015295:Antigens, Tumor-Associated, Carbohydrate; D006684:HLA-DR Antigens