Coexistence of paired helical filaments and glial filaments in astrocytic processes within ghost tangles.
Ultrastructural examination of ghost tangles in an autopsy case of long-term Alzheimer's disease revealed, in addition to degenerate neurites containing paired helical filaments (PHF), astrocytic processes which included PHF. This finding suggests either that astrocytes in ghost tangles possess the capacity to produce PHF or that PHF are incorporated into astrocytes by endocytosis.
Ikeda
K
K
Tokyo Institute of Psychiatry, Japan.
Haga
C
C
Akiyama
H
H
Kase
K
K
Iritani
S
S
D008841:Actin Cytoskeleton / Q000648:ultrastructure*; D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology*; D000911:Antibodies, Monoclonal; D001253:Astrocytes / Q000473:pathology* / Q000648:ultrastructure; D001344:Autopsy; D001921:Brain / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007365:Intercellular Junctions / Q000648:ultrastructure; D016501:Neurites / Q000648:ultrastructure; D016874:Neurofibrillary Tangles / Q000648:ultrastructure*; D009474:Neurons / Q000473:pathology / Q000648:ultrastructure; D014452:Ubiquitins / Q000032:analysis
D000911:Antibodies, Monoclonal; D014452:Ubiquitins