Effects of tetanus toxin, Salmonella typhimurium porin, and bacterial lipopolysaccharide on platelet aggregation.
Endotoxins may interfere with platelet aggregation by interacting with the platelet membrane. The aim of this study was to evaluate the effects of tetanus toxin, Salmonella typhimurium porin, and bacterial lipopolysaccharide (LPS) on platelet aggregation induced by ADP and thrombin in vitro. Spontaneous platelet aggregation and platelet aggregation induced by ADP and thrombin were measured. Our results show that Salmonella typhimurium porin and bacterial LPS enhanced human and rabbit platelet aggregation induced by ADP and thrombin. Tetanus toxin did not affect platelet aggregation.
Matera
C
C
Institute of Pharmacology and Toxicology, University of Naples Federico II, Italy.
Falzarano
C
C
Berrino
L
L
Rossi
F
F
D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D018272:Porins; D011817:Rabbits; D012486:Salmonella typhimurium; D013745:Tetanus Toxoid / Q000494:pharmacology*
D001425:Bacterial Outer Membrane Proteins; D008070:Lipopolysaccharides; D018272:Porins; D013745:Tetanus Toxoid