title: Protein tyrosine kinases in nervous system development.
abstract: Protein tyrosine kinases are important mediators of intracellular signaling during nervous system development. Activation of receptor protein tyrosine kinases by neurotrophic factors are initial events in the development of discrete cell populations. The patterns of expression and characterization of substrates for nonreceptor protein tyrosine kinases indicates that they also play a crucial role in neuronal development. The observed functional redundancy among protein tyrosine kinases and their associated intracellular signaling pathways underscores the need for further characterization of these novel interactions to elucidate the mechanisms regulating nervous system development.
authors.affiliation: Department of Biochemistry, University of North Carolina School of Medicine, Chapel Hill 27599-7260.
authors.forename: P F
authors.initials: PF
authors.lastname: Maness
authors.forename: M E
authors.initials: ME
authors.lastname: Cox
mesh_terms: D000818:Animals; D009420:Nervous System / Q000196:embryology / Q000201:enzymology*; D011505:Protein-Tyrosine Kinases / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology; D017468:Receptors, Fibroblast Growth Factor; D017475:Receptors, Nerve Growth Factor
chemical_list: D011956:Receptors, Cell Surface; D017468:Receptors, Fibroblast Growth Factor; D017475:Receptors, Nerve Growth Factor; D011505:Protein-Tyrosine Kinases