Supernumerary ring chromosomes in five bone and soft tissue tumors of low or borderline malignancy.
Five tumors (two myxoid malignant fibrous histiocytoma, two dermatofibrosarcoma protuberans, and one parosteal osteosarcoma) with ring chromosomes as the sole cytogenetic anomaly or as the only structural rearrangement were observed in a series of 60 karyotypically abnormal, nonlipogenic bone and soft tissue tumors (BST). All five tumors were of borderline or low malignancy. These findings support the suggestion that supernumerary ring chromosomes as the sole structural chromosomal aberration are not associated with any particular histopathologic diagnosis but may characterize a group of BST of borderline or low malignancy.
Orndal
C
C
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Mandahl
N
N
Rydholm
A
A
Willén
H
H
Brosjö
O
O
Heim
S
S
Mitelman
F
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001132:Arm; D001859:Bone Neoplasms / Q000235:genetics*; D005260:Female; D005269:Femur; D005354:Fibrosarcoma / Q000235:genetics; D006119:Groin; D018219:Histiocytoma, Benign Fibrous / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000235:genetics; D012303:Ring Chromosomes; D012782:Shoulder; D012983:Soft Tissue Neoplasms / Q000235:genetics*