[Chromosomal restructurings and the distribution of chromosome fragile sites in the peripheral blood lymphocytes in a breast cancer patient after cytostatic therapy].
Cytogenetic analysis was performed repeatedly on a breast cancer patient since the beginning of the antitumor treatment. Double minute chromosomes (DMS, 2-10 per cell) were found in less than 2% of peripheral blood lymphocytes besides other chromosomal abnormalities after radiation therapy and 8 months after chemotherapy. The level of structural chromosomal aberrations two years after the therapeutic treatment was 0.13-0.14 aberrations per cell, but DMS were not observed. Estimation of the fragile site (FS) frequency and distribution at this time revealed a significant expression of the common FS FRAGF (9q1.2) after the treatment of blood culture with 5-bromo-2-deoxyuridine at dose levels of 7 and 50 g/l and enhanced fragility in chromosome band 1p35-36.1 (FRA1A) in folate-deprived conditions. Rare FS were not found. The presented data are discussed.
Iakovleva
T K
TK
Monakhov
A S
AS
Moiseenko
V M
VM
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000097:blood* / Q000188:drug therapy; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000097:blood* / Q000188:drug therapy; D002869:Chromosome Aberrations; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000648:ultrastructure*; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D012303:Ring Chromosomes; D013629:Tamoxifen / Q000008:administration & dosage; D013997:Time Factors
D013629:Tamoxifen; D005472:Fluorouracil; D008727:Methotrexate
Khromosomnye perestroĭki i raspredelenie saĭtov lomkosti khromosom v limfotsitakh perifericheskoĭ krovi bol'noĭ rakom molochnoĭ zhelezy posle tsitostaticheskoĭ terapii.