Acute respiratory failure during pneumonia induced by Sendai virus.
In this study a model of acute respiratory failure due to viral pneumonia in rats, closely resembling ARDS, is presented. Severe respiratory failure with lethal outcome in four days was induced by infection concentrated Sendai virus aerosol. This model permits evaluation of different therapeutical approaches for improving gas exchange during ARDS. Furthermore, preliminary results of surfactant substitution therapy in this model are presented.
van Daal
G J
GJ
Dept of Anesthesiology, Erasmus University Rotterdam, The Netherlands.
Eijking
E P
EP
So
K L
KL
Fievez
R B
RB
Sprenger
M J
MJ
van Dam
D W
DW
Erdmann
W
W
Lachmann
B
B
D000818:Animals; D004195:Disease Models, Animal; D008297:Male; D010222:Parainfluenza Virus 1, Human / Q000472:pathogenicity*; D018184:Paramyxoviridae Infections / Q000209:etiology*; D011024:Pneumonia, Viral / Q000209:etiology*; D011659:Pulmonary Gas Exchange / Q000187:drug effects; D011663:Pulmonary Surfactants / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D012128:Respiratory Distress Syndrome / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D012131:Respiratory Insufficiency / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology
D011663:Pulmonary Surfactants