title: Alpha- and beta-adrenergic receptors in children with essential hypertension.
abstract: Platelet alpha 2- and lymphocyte beta-adrenergic receptors were examined in eight children aged 10-16 years with essential hypertension, and in 11 age-matched normotensive children. Both alpha 2- and beta-adrenergic receptor concentrations showed no significant differences between children with essential hypertension and normotensive children. According to other studies, physiological fluctuations in catecholamines determine lymphocyte beta-adrenergic receptor concentrations, although down-regulation in platelet alpha 2-adrenergic receptors has not been observed. The present findings suggest that there may be no abnormalities in alpha 2- and beta-adrenergic receptors in essential hypertension in childhood, although a hyperadrenergic state has been reported to be of some relevance to the pathogenesis of essential hypertension in young adolescents.
authors.affiliation: Department of Pediatrics, Oita Medical University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Uchiyama
authors.forename: H
authors.initials: H
authors.lastname: Hayakawa
authors.forename: T
authors.initials: T
authors.lastname: Ogawa
mesh_terms: D000293:Adolescent; D001792:Blood Platelets / Q000737:chemistry*; D002648:Child; D004082:Dihydroalprenolol; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D007564:Japan / Q000453:epidemiology; D008214:Lymphocytes / Q000737:chemistry*; D008297:Male; D011942:Receptors, Adrenergic, alpha / Q000737:chemistry*; D011943:Receptors, Adrenergic, beta / Q000737:chemistry*; D014316:Tritium
chemical_list: D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D014316:Tritium; D004082:Dihydroalprenolol