[Human papillomavirus type 16 and human cytomegalovirus in cervical carcinoma].
Using techniques of DNA-DNA dot blot hybridization, we examined 98 cervical specimens for the presence of human papillomavirus type 16 HPV-16 and human cytomegalovirus (HCMV) sequence and analysed the relationship between virus infection and various cervical diseases, age of patients, age at first coitus, age of first child birth, the number of pregnancy, use of oral contraceptives. The results showed that the rate of HPV DNA and HCMV DNA positivity in cervical carcinoma is significantly higher than that of non-carcinomatous tissue. In addition, the positivity correlates with age, at first intercourse, but not with age of first child birth, the number of pregnancy and use of oral contraceptives. These data suggested that HPV-16 and HCMV infection is associated with cervical carcinoma. Some cases of cervical erosion with HPV infection may lead to cervical. The high incidence of cervical carcinoma in women married early in life may be related to virus infection in adolescence. HPV acting with other synergistic factors, such as HCMV is considered to lead to the occurrence of cervical carcinoma.
Cai
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Second Hospital Attach, Hubei Medical College, Wuhan.
D000328:Adult; D000367:Age Factors; D003587:Cytomegalovirus / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D015151:Immunoblotting; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification*; D014412:Tumor Virus Infections; D002583:Uterine Cervical Neoplasms / Q000382:microbiology*
D004279:DNA, Viral