[Pharmacokinetics and metabolism of pipecuronium bromide (Arduan)].
The pharmacokinetics of pipecuronium bromide (Arduan) studied in animals (rat, dog, cat) and in humans can be described by a two-compartment open model. The elimination half-life in animals was found to be around 40 min, in humans between 44-137 min. The main route of elimination is the excretion of the unchanged molecule in urine. In kidney patients the elimination becomes longer. The metabolism in the elimination is less important, in rats 3-hydroxy-, 17-hydroxy and 3,17-dihydroxy metabolites have been identified.
Vereczkey
L
L
Gyógyszerkutató Intézet, Budapest.
D015113:Androstane-3,17-diol / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics; D000818:Animals; D006801:Humans; D009466:Neuromuscular Blocking Agents / Q000378:metabolism* / Q000493:pharmacokinetics; D017300:Pipecuronium; D010879:Piperazines / Q000378:metabolism* / Q000493:pharmacokinetics
D009466:Neuromuscular Blocking Agents; D010879:Piperazines; D017300:Pipecuronium; D015113:Androstane-3,17-diol
A pipecuronium bromid (Arduan) farmakokinetikája és metabolizmusa.