[Effect of 9-alpha-fluorhydrocortisone (Florinef) in extrarenal regulation of potassium].
There are evidences that adrenal hormones regulate extrarenal potassium homeostasis. The present study evaluated the effect of Florinef modulation on extrarenal mechanisms in potassium adaptation of adrenalectomized rats. The results demonstrated that the rats treated with Florinef had serum potassium levels at normal range probably due to an increase in cellular potassium uptake consequently to en enhanced activity of Na-K-ATPase.
Helou
C M
CM
Laboratório de Pesquisa Básica da Disciplina de Nefrologia, Faculdade de Medicina, Universidade de São Paulo.
Seguro
A C
AC
Rocha
A dos S
Ados S
D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000315:Adrenalectomy; D000818:Animals; D005438:Fludrocortisone / Q000494:pharmacology*; D006706:Homeostasis / Q000187:drug effects; D008297:Male; D011188:Potassium / Q000097:blood / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000097:blood; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium; D005438:Fludrocortisone
Efeito da 9-alfa-fluoridrocortisona (Florinef) na regulação extra-renal do potássio.