title: Trends in childhood and adolescent cancer survival in Sweden 1960 through 1984.
abstract: The temporal changes in childhood and adolescent cancer survival in Sweden 1960-1984 were analyzed. Complete follow-up through 1986 of 6,262 patients younger than 20 years at diagnosis revealed that the overall 5-year survival rates increased from 36.1 to 65.7% in males and from 43.6 to 73.6% in females. The temporal trends differed markedly between age groups and tumour sites and types. Over the study period, 5-years, survival for testicular cancer increased from 46.9 to 87.2%, kidney cancer, predominantly Wilms' tumour from 35.5 to 77.1% (with a higher rate of 89.1% in 1975-1979), Hodgkin's disease from 61.2 to 91.9%, non-Hodgkin's lymphoma from 32.5 to 76.6%, and all leukemias from 8.9 to 58.7%. Only a moderate improvement was noted for tumours of the bone, muscle and connective tissue, and survival rates for tumours of the nervous system remained largely unchanged. Our data reflect the remarkable therapeutic improvements that have occurred for cancer in the young and indicate that these improvements have rapidly become available in Sweden.
authors.affiliation: Cancer Epidemiology Unit, University Hospital, Uppsala, Sweden.
authors.forename: H O
authors.initials: HO
authors.lastname: Adami
authors.forename: B
authors.initials: B
authors.lastname: Glimelius
authors.forename: P
authors.initials: P
authors.lastname: Sparén
authors.forename: L
authors.initials: L
authors.lastname: Holmberg
authors.forename: U B
authors.initials: UB
authors.lastname: Krusemo
authors.forename: J
authors.initials: J
authors.lastname: Pontén
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006689:Hodgkin Disease / Q000453:epidemiology / Q000401:mortality / Q000628:therapy; D006801:Humans; D007680:Kidney Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000628:therapy; D007938:Leukemia / Q000453:epidemiology / Q000401:mortality / Q000628:therapy; D008017:Life Expectancy / Q000639:trends*; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000401:mortality / Q000628:therapy; D008297:Male; D009369:Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000628:therapy*; D011379:Prognosis; D012042:Registries; D012727:Sex Characteristics; D013548:Sweden / Q000453:epidemiology; D013736:Testicular Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000628:therapy; D009396:Wilms Tumor / Q000453:epidemiology / Q000401:mortality / Q000628:therapy