The role of atrial natriuretic peptide in natriuresis of fasting.
OBJECTIVE
To examine the relation between plasma atrial natriuretic peptide (ANP) and the natriuresis of fasting.


METHODS
ANP, aldosterone and renin were examined during natriuresis of fasting in 25 obese essential hypertensive patients and nine overweight normotensive subjects placed on a supervised 500-KCal diet composed of 50% carbohydrates, 30% fat and 20% protein, and unlimited salt. Twenty-four-hour urinary electrolytes were measured on days 0, 4, 7 and 10 of the diet.


RESULTS
Urinary sodium concentration nearly doubled in the patients on day 4, and increased 1.4-fold in the normotensive controls. Plasma ANP rose nearly threefold in the hypertensives on day 4 and nearly doubled in the normotensives. Patients and controls showed similar patterns of natriuresis and ANP secretion during the diet.


CONCLUSIONS
We conclude that there is a clear association between ANP levels and natriuresis of fasting.
Maoz
E
E
Chorley Hypertension Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Shamiss
A
A
Peleg
E
E
Salzberg
M
M
Rosenthal
T
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000097:blood*; D005215:Fasting / Q000502:physiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009318:Natriuresis / Q000502:physiology*; D009765:Obesity / Q000150:complications / Q000503:physiopathology*; D012964:Sodium / Q000652:urine
D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012964:Sodium