[Effect of opioid receptor blockade with naloxone on vasopressin secretion in patients with transplanted kidney].
The present study aimed to assess the influence of opioid receptors on vasopressin (AVP) secretion in 12 kidney transplant patients (KTP) with stable graft function, and in 15 healthy subjects (control). Significantly lower basal plasma AVP levels were found in KTP than in controls. After blockade of opioid receptors by naloxone a significant increase of plasma AVP levels were observed in both examined groups. This increase was significantly higher in KTP than in healthy subjects. From data presented in this study participation of opioid receptors in the regulation of AVP secretion is highly likely both in KTP and controls. This participation seems to be significantly greater in KTP than in healthy subjects.
Grzeszczak
W
W
Klinika Nefrologii Sl. AM, Katowice.
Zukowska-Szczechowska
E
E
Kokot
F
F
D000328:Adult; D001127:Arginine Vasopressin / Q000378:metabolism* / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology* / Q000601:surgery; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009270:Naloxone / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000187:drug effects*; D013268:Stimulation, Chemical
D011957:Receptors, Opioid; D001127:Arginine Vasopressin; D009270:Naloxone
Wpływ blokady receptorów opioidowych naloksonem na wydzielanie wazopresyny u chorych z przeszczepiona nerka.