The inhibiting effect of catecholamine-melanins on UV-induced lecithin peroxidation.
It was found that the yield of thiobarbituric acid reactive substances in UV-irradiated liposome membranes was significantly suppressed in the presence of catecholamine-melanins, indicating their ability to inhibit lipid peroxidation. The extent of inhibition depended on the type and concentration of melanin polymers. Melanin-copper complexes inhibited lecithin photooxidation less effectively than copper-free melanins derived from the same precursor. The antioxidant efficiency of melanins appears to be related to the levels of intrinsic and photo-induced free radical centers in the melanin polymer, as well as to accessibility of these centers for active species formed during irradiation of liposomes.
Stepień
K
K
Department of Biochemistry and Biophysics, Faculty of Pharmacy, Silesian Medical Academy, Sosnowiec, Poland.
Porebska-Budny
M
M
Hollek
A M
AM
Wilczok
T
T
D002395:Catecholamines; D004295:Dihydroxyphenylalanine; D004298:Dopamine; D004578:Electron Spin Resonance Spectroscopy; D004837:Epinephrine; D007211:Indoles; D007700:Kinetics; D015227:Lipid Peroxidation; D008543:Melanins; D009638:Norepinephrine; D010713:Phosphatidylcholines / Q000528:radiation effects*; D014466:Ultraviolet Rays
D002395:Catecholamines; D007211:Indoles; D008543:Melanins; D010713:Phosphatidylcholines; C054791:adrenolutin; D004295:Dihydroxyphenylalanine; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine