title: The Na+/H+ antiporter in oncology in the light of the spontaneous regression of cancer and cell metabolism.
abstract: Multiple metabolic and biochemical interrelationships, as well as the most recent views on mechanisms of malignant cell growth, proliferation, and oncogen activity mediated by the Na+/H+ antiporter, can be integrated from the unitarian point of view of the dynamics of the hydrogen ion to parallel pH-related mechanisms involved in the Spontaneous Regression (SR) of some malignant tumors. Also, pH-related growth inhibitors of the amiloride series are considered as possible agents to be used in the adjuvant and co-adjuvant treatment of some human tumors as well as in the control of the metastatic process and in overcoming cancer multidrug resistance (MDR).
authors.affiliation: Clinica La Esperanza, Vitoria, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Harguindey
authors.forename: E J
authors.initials: EJ
authors.lastname: Cragoe
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008954:Models, Biological; D009365:Neoplasm Regression, Spontaneous / Q000503:physiopathology*; D009369:Neoplasms / Q000150:complications / Q000378:metabolism; D011522:Protons; D012964:Sodium / Q000378:metabolism; D017923:Sodium-Hydrogen Exchangers
chemical_list: D002352:Carrier Proteins; D011522:Protons; D017923:Sodium-Hydrogen Exchangers; D012964:Sodium