Recurrent cutaneous anaplastic large cell (CD30+) lymphoma associated with Epstein-Barr virus. A case report with 9-year follow-up.
CD30-positive large cell cutaneous T-cell lymphomas are known to be associated with the human T-cell leukemia/lymphoma virus type I. We present a case of anaplastic large cell lymphoma that recurred three times during 9 years at different sites. Molecular studies [polymerase chain reaction (PCR), in situ hybridization] showed Epstein-Barr virus (EBV) genome in biopsy samples of this first reported case of EBV-associated cutaneous anaplastic large cell lymphoma. This case was human T-lymphotropic virus-1 and -2 negative by PCR. The results add some evidence to the hypothesis that EBV may be a factor in the pathogenesis of cutaneous lymphoproliferative lesions.
Borisch
B
B
Institute of Pathology, University of Bern, Switzerland.
Böni
J
J
Bürki
K
K
Laissue
J A
JA
D001483:Base Sequence; D004279:DNA, Viral / Q000032:analysis; D016679:Genome, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology; D014412:Tumor Virus Infections / Q000150:complications* / Q000473:pathology
D004279:DNA, Viral