title: [Itraconazole action on Toxoplasma gondii].
abstract: With the purpose to increase our knowledge about the spectrum of therapeutic action of itraconazole, the activity of a new triazolic derivative against Toxoplasma gondii was studied in vivo and in vitro with the aid of an experimental infection model in mice. The trial also aimed at a possible improvement of the therapy of toxoplasmosis in regard to safety and dosing easiness. The present study has not shown significant activity of itraconazole against Toxoplasma gondii, differing from a previous observation that showed it's activity against Trypanosoma cruzi.
authors.affiliation: Setor de Toxoplasmose, Instituto de Medicina Tropical de São Paulo.
authors.forename: L M
authors.initials: LM
authors.lastname: Jamra
authors.forename: V
authors.initials: V
authors.lastname: Amato Neto
authors.forename: L M
authors.initials: LM
authors.lastname: Braz
authors.forename: M E
authors.initials: ME
authors.lastname: Camargo
mesh_terms: D000818:Animals; D017964:Itraconazole; D007654:Ketoconazole / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D014124:Toxoplasmosis, Animal / Q000188:drug therapy*
chemical_list: D017964:Itraconazole; D007654:Ketoconazole
vernacular_title: Observações relativas à ação do itraconazol sobre o Toxoplasma gondii.