[Potential-dependent Ca2+ channels and contractile function of the heart in toxic-infectious shock caused plague].
Influence of intravenous administration to rats of murine toxin of Y. pestis (1 mg/ml, LD100) on the number of potential-operated Ca(2+)-channels, alpha- and beta-adrenergic and M1-cholinergic receptors of plasma membranes and heart contractility function has been studied in rats. The number of Ca(2+)-channels in plasma membranes and contractility of heart decreased by 50% in 1 hour after the i.v. administration of toxin and further decreased up to the lethal end. During the agonal stage of the shock desensitization of beta-adrenergic receptors has been discovered, while alpha-adrenergic and M1-cholinergic receptors remained unchanged throughout the experiments.
Cherkisova
T D
TD
Iurkiv
V A
VA
Avrorov
V P
VP
Griboedov
A V
AV
D000818:Animals; D015220:Calcium Channels / Q000502:physiology*; D002462:Cell Membrane / Q000737:chemistry; D008297:Male; D009200:Myocardial Contraction; D010930:Plague / Q000503:physiopathology*; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000032:analysis; D011943:Receptors, Adrenergic, beta / Q000032:analysis; D011950:Receptors, Cholinergic / Q000032:analysis; D012772:Shock, Septic / Q000503:physiopathology*; D015010:Yersinia pestis
D015220:Calcium Channels; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D011950:Receptors, Cholinergic
Potentsialzavisimye Ca2+-kanaly i sokratitel'naia funktsiia serdtsa v dinamike chumnogo toksiko-infektsionnogo shoka.