[The vagotropic action of peptides isolated from the brain of hibernating susliks].
Dipeptide ASP-TYR extracted from the brain of hibernating squirrels was found to potentiate vagal effect on the cardiac rhythm, whereas pentapeptide neokyotorphin--to diminish it. In both cases the effect was due to an alteration of the tonic component's strength in the vagal chronotropic effect. The selective peptidergic modulation of the vagal effect on the cardiac rhythm suggests different physiological roles of the tonic and synchronizing components in regulation of the heart.
Pokrovskiĭ
V M
VM
Osadchiĭ
O E
OE
Sheĭkh-zade
Iu R
IuR
Sviriaev
V I
VI
Vas'kovskiĭ
B V
BV
Ziganshin
R Kh
RKh
Mikhaleva
I I
II
D000818:Animals; D001921:Brain / Q000502:physiology*; D002415:Cats; D004151:Dipeptides / Q000302:isolation & purification / Q000494:pharmacology*; D004558:Electric Stimulation; D004562:Electrocardiography / Q000187:drug effects; D004723:Endorphins / Q000302:isolation & purification / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006605:Hibernation / Q000502:physiology*; D012589:Sciuridae / Q000502:physiology*; D013997:Time Factors; D014630:Vagus Nerve / Q000187:drug effects* / Q000502:physiology
D004151:Dipeptides; D004723:Endorphins; C078779:aspartyltyrosine; C036450:neo-kyotorphin
Vagotropnoe deĭstvie peptidov, vydelennykh iz mozga giberniruiushchikh suslikov.