An experimental approach to understanding the genetic and neurobiological basis of alcoholism.
The development and characterization of an animal model to study mechanisms underlying abnormal alcohol-seeking behavior have been described. Raised by genetic means, it demonstrates the importance of genetic factors in this behavior. It has allowed the elucidation of neural pathways and neurotransmitter systems that subserve alcohol-seeking behavior. It offers the potential for screening new medications for the treatment of alcoholism, based upon these kinds of newly discovered knowledge.
Li
T K
TK
Indiana University School of Medicine, Indianapolis.
Lumeng
L
L
McBride
W J
WJ
Murphy
J M
JM
D000428:Alcohol Drinking / Q000235:genetics; D000437:Alcoholism / Q000209:etiology* / Q000235:genetics* / Q000503:physiopathology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000503:physiopathology; D004195:Disease Models, Animal; D000431:Ethanol / Q000633:toxicity; D005260:Female; D006801:Humans; D008297:Male; D051381:Rats
D000431:Ethanol