[Chronopharmacology of fractionated heparin (nadroparin) administrated by subcutaneous route at prophylactic doses in healthy volunteers].
This study evaluated the effect of injection time on pharmacodynamic of a single subcutaneous bolus of nadroparine (7500 anti-Xa IC U) evaluated by anti-Xa activity (Hepaclot and Heptest) and by activated partial thromboplastin time (APTT by auto PTT reagent). 10 healthy male volunteers were studied at 4 different 24 hours periods with 4 different injection times (6 am, 12 am, 6 pm, 12 pm) and with a one week wash-out period between each period. No chronopharmacological variation of the anti-Xa activity evaluated by Hepaclot was found. However the anti-Xa activity evaluated by Heptest was higher at the sixth hour after 12 am injection (p = 0.0022). No difference on APTT values was observed whatever the injection time. So the injection time of nadroparine has a weak influence on anti-Xa activity and no effect on APTT; Before to conclude on the lack of chronopharmacological effect of nadroparine, it seems necessary to evaluate such a possibility with higher dosage, with sick and older subjects.
Mismetti
P
P
Unité de Pharmacologie Clinique, CHRU de Saint-Etienne.
Perpoint
B
B
Laporte-Simitsidis
S
S
Tardy-Poncet
B
B
Reynaud
J
J
Cherrah
Y
Y
Ollagnier
M
M
Queneau
P
P
Decousus
H
H
D000328:Adult; D002909:Chronobiology Phenomena; D002940:Circadian Rhythm; D004334:Drug Administration Schedule; D005170:Factor X / Q000037:antagonists & inhibitors; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D010714:Phosphatidylethanolamines / Q000378:metabolism; D014838:Volunteers
D006495:Heparin, Low-Molecular-Weight; D010714:Phosphatidylethanolamines; D005170:Factor X
Chronopharmacologie d'une héparine fractionnée (nadroparine) administrée par voie sous-cutanée à dose prophylactique chez le voluntaire sain.