Participation of a GABA-ergic system in the processes of neuroimmunomodulation.
Participation of a GABA-ergic system in neuroimmunomodulation was established through the use of a large number of chemical compounds which selectively modulate the activity of the GABA-BD-receptor-ionophore complex. Activation of the GABA-receptors with muscimol or activation of the BD-receptors with diazepam or tazepam had stimulatory effects upon immunogenesis. A decrease in the GABA-BD-receptor-ionophore complex activity led to a suppression of the immune response. The effect was achieved with: a blockade of the complex with bicuculline--a competitive inhibitor of the GABA-receptors: administration of a specific antagonist of the BD-receptors flumazenil or Ro 15-3505: or with blockade of chloride channels with picrotoxin. Activation of the GABA-ergic system causes an increase in bone marrow content of T-helper cells marked by L3T4. The immunomodulatory action of the GABA-ergic system is of central origin and can occur only when the hypothalamo-pituitary system is intact. Section of the pituitary stalk prevents accumulation of the T-helper cells in the bone marrow. The result show that the influence of GABA-ergic system on immunogenesis requires participation of both dopaminergic and serotoninergic systems.
Devoino
L
L
Institute of Physiology Siberian Branch, Academy of Medical Sciences, USSR, Novosibirsk.
Idova
G
G
Beletskaya
I
I
D000818:Animals; D004298:Dopamine / Q000276:immunology / Q000378:metabolism; D005260:Female; D007107:Immune System / Q000378:metabolism; D008297:Male; D051379:Mice; D015213:Neuroimmunomodulation; D010641:Phenotype; D011963:Receptors, GABA-A / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D012397:Rosette Formation; D012701:Serotonin / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D011963:Receptors, GABA-A; D012701:Serotonin; D004298:Dopamine