Sequence of a second human KDEL receptor.
Retention of luminal endoplasmic reticulum (ER) proteins is mediated via a conserved carboxy-terminal tetrapeptide that serves as a signal for their retrieval from subsequent compartments of the secretory pathway. The signal is recognized by a receptor molecule that is believed to cycle between the Golgi apparatus and the ER. This receptor in Saccharomyces cerevisiae is encoded by the ERD2 gene, and a human cDNA homologue of the gene has been isolated. Binding of ligand by the product of this gene results in a shift of its steady-state location from Golgi to ER, suggesting that retrograde transport has been triggered. Here we report the identification of a related human protein with similar properties. This indicates that there are at least two distinct genes in humans that encode functional KDEL receptors.
Lewis
M J
MJ
MRC Laboratory of Molecular Biology, Cambridge, U.K.
Pelham
H R
HR
D000595:Amino Acid Sequence; D001483:Base Sequence; D001692:Biological Transport; D002478:Cells, Cultured; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics*; D021382:Protein Sorting Signals / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000235:genetics*; D018000:Receptors, Peptide; D012689:Sequence Homology, Nucleic Acid
C064459:KDEL receptor; D021382:Protein Sorting Signals; D011956:Receptors, Cell Surface; D018000:Receptors, Peptide