[Expression of gene products of insulin-like-growth-factor II, insulin-like-growth-factor II receptor and colony-stimulating-factor-I receptor in human primary hepatocellular carcinoma and non-cancerous liver tissues].
Western blot technique was used to detect the expression of gene products of IGF-II and IGF-II receptor as well as CSF-1 receptor in hepatocellular carcinoma and its adjacent nontumours liver tissue. A fetal expression of IGF-II was noted in 33 KD. IGF-II receptor was expressed in 260 KD and 230 KD with mature and immature forms, and CSF-1 receptor in 180 KD, 139KD and 122KD with different forms. The close relationship between the synthesized regulation and overexpression of three gene protein products and hepatocarcinogenesis was discussed.
Yang
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Department of Internal Medicine, First Affiliated Hospital, Third Military Medical College, Chongqing.
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000235:genetics*; D008099:Liver / Q000378:metabolism; D008113:Liver Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D017527:Receptor, IGF Type 2 / Q000235:genetics*; D016184:Receptors, Colony-Stimulating Factor / Q000235:genetics*
D017527:Receptor, IGF Type 2; D016184:Receptors, Colony-Stimulating Factor; D007335:Insulin-Like Growth Factor II