title: The influence of HLA A-B-DR matching on cytomegalovirus disease after renal transplantation. Evidence that HLA-DR7-matched recipients are more susceptible to cytomegalovirus disease.
abstract: We examined the prevalence of cytomegalovirus infectious episodes, as defined by clinical, virological, and serological criteria (i.e., CMV disease), in 660 kidney graft recipients; 109 patients (16.5%) developed the disease, and 551 did not. No significant statistical link between CMV disease prevalence and a given HLA-A, -B, or -DR allele was observed. However, patients with HLA-DR7 matched grafts were statistically more frequently found (P < 0.01) in the group of recipients who developed CMV disease as compared with the group who did not develop CMV disease. Furthermore, among patients who developed CMV disease, a significant increase of HLA-DR7 matched over DR7 mismatched patients was noted, whereas no difference between matched and mismatched recipients for the other HLA-DR alleles was found. No difference in the severity of graft failure, often observed during, or immediately after, the CMV episode, was noted between patients matched or mismatched for HLA-DR7. Our data suggest that donor/recipient matching for HLA-DR7 is associated with increased CMV disease.
authors.affiliation: Service de Néphrologie--Immunologie Clinique, INSERM U.211, Unité de Recherche sur les Effecteurs Lymphocytaires, Plateau Technique du C.H.R., Nantes, France.
authors.forename: G
authors.initials: G
authors.lastname: Blancho
authors.forename: R
authors.initials: R
authors.lastname: Josien
authors.forename: D
authors.initials: D
authors.lastname: Douillard
authors.forename: J D
authors.initials: JD
authors.lastname: Bignon
authors.forename: A
authors.initials: A
authors.lastname: Cesbron
authors.forename: J P
authors.initials: JP
authors.lastname: Soulillou
mesh_terms: D000483:Alleles; D003586:Cytomegalovirus Infections / Q000453:epidemiology / Q000276:immunology*; D006084:Graft Rejection / Q000453:epidemiology; D006085:Graft Survival; D015234:HLA-A Antigens / Q000032:analysis* / Q000235:genetics; D015235:HLA-B Antigens / Q000032:analysis* / Q000235:genetics; D006684:HLA-DR Antigens / Q000032:analysis* / Q000235:genetics; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects / Q000276:immunology; D010641:Phenotype; D015995:Prevalence
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens