Redox chemistry of complexes of nickel(II) with some biologically important peptides in the presence of reduced oxygen species: an ESR study.
The reactions between some Ni(II) oligopeptides (Gly-His-Lys, (Gly)4, Asp-Ala-His-Lys, Gly-Gly-His, beta Ala-His, and serum albumin) and reduced oxygen species have been characterized by spin-trapping experiments using DMPO and Me2SO. Most of the peptides possessed superoxide dismutase- and catalase-like activities leading to the formation of either oxene [NiO]2+ or, in the case of beta Ala-His, hydroxyl radicals. Both these species may affect DNA integrity through distinct mechanisms.
Cotelle
N
N
Unité 16 INSERM, Lille, France.
Trémolières
E
E
Bernier
J L
JL
Catteau
J P
JP
Hénichart
J P
JP
D000595:Amino Acid Sequence; D000838:Anions; D003497:Cyclic N-Oxides; D004578:Electron Spin Resonance Spectroscopy; D006861:Hydrogen Peroxide / Q000378:metabolism; D008969:Molecular Sequence Data; D009532:Nickel / Q000378:metabolism*; D009842:Oligopeptides / Q000378:metabolism*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*; D013113:Spin Labels; D013481:Superoxides / Q000378:metabolism; D019820:Xanthine; D014969:Xanthine Oxidase / Q000378:metabolism; D014970:Xanthines / Q000378:metabolism
D000838:Anions; D003497:Cyclic N-Oxides; D009842:Oligopeptides; D013113:Spin Labels; D014970:Xanthines; D013481:Superoxides; D019820:Xanthine; C017245:5,5-dimethyl-1-pyrroline-1-oxide; D009532:Nickel; D006861:Hydrogen Peroxide; D014969:Xanthine Oxidase; D010100:Oxygen