title: Biology of Hodgkin's disease.
abstract: The biology of Hodgkin's disease is one of the most intriguing subjects in lymphoma research. The presence of only a small proportion of neoplastic cells and a vast majority of reactive cells reflects the presence of complex interactions between these cell types. In this paper we discuss findings indicating that Reed-Sternberg cells may be virally transformed cells that have evaded a cytotoxic immune response and induce an ineffective delayed type hypersensitivity reaction.
authors.affiliation: Department of Laboratory Medicine, Cross Cancer Institute, University of Alberta.
authors.forename: S
authors.initials: S
authors.lastname: Poppema
authors.forename: J
authors.initials: J
authors.lastname: Kaleta
authors.forename: B
authors.initials: B
authors.lastname: Hepperle
authors.forename: L
authors.initials: L
authors.lastname: Visser
mesh_terms: D002472:Cell Transformation, Viral / Q000235:genetics / Q000276:immunology; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D016679:Genome, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics; D006689:Hodgkin Disease / Q000209:etiology / Q000235:genetics / Q000276:immunology*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000235:genetics / Q000276:immunology; D016539:Reed-Sternberg Cells / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology