Apomorphine induction of AP-1 DNA binding in the rat striatum after dopamine depletion.
The expression of AP-1 transcription factors was assessed in the dopamine-depleted rat striatum over a 1 week period of repeated apomorphine injections. A single injection of apomorphine increased the expression of a 35 kDa Fos-related antigen and Jun proteins and their expression continued to increase until day 3 of repeated apomorphine treatment in dopamine-depleted striata. Apomorphine induces AP-1 transcription factors which may be involved in modulating gene expression in the striatum.
Pennypacker
K R
KR
Neuropharmacology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709.
Zhang
W Q
WQ
Ye
H
H
Hong
J S
JS
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001483:Base Sequence; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004247:DNA / Q000378:metabolism*; D004298:Dopamine / Q000502:physiology*; D016762:Genes, fos; D008297:Male; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000096:biosynthesis; D016627:Oxidopamine; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar; D013563:Sympathectomy, Chemical; D014157:Transcription Factors / Q000378:metabolism
D009687:Nuclear Proteins; D016760:Proto-Oncogene Proteins c-fos; D014157:Transcription Factors; D016627:Oxidopamine; D004247:DNA; D001058:Apomorphine; D004298:Dopamine