Trisomy 12 and 4 in a thecoma of the ovary.
Cytogenetic analysis of short-term tissue culture from a thecoma of the ovary demonstrated the presence of trisomies of chromosomes 12 and 4 in all analyzed cells. Our finding confirms the consistency with which trisomy 12 is observed in benign sex cord/stromal tumors and suggests that trisomy 4 may be a second event in tumorigenesis of thecoma.
Mrózek
K
K
Department of Biology and Genetics, Medical Academy, Gdansk, Poland.
Limon
J
J
Debniak
J
J
Emerich
J
J
D002881:Chromosomes, Human, Pair 12; D002894:Chromosomes, Human, Pair 4; D005260:Female; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000235:genetics*; D013798:Thecoma / Q000235:genetics*; D014314:Trisomy; D014407:Tumor Cells, Cultured / Q000473:pathology