Sural nerve biopsies in Guillain-Barre syndrome: axonal degeneration and macrophage-associated demyelination and absence of cytomegalovirus genome.
T-cell infiltration was detected by immunohistochemistry in only 2 of 10 sural nerve biopsies from patients with Guillain-Barré syndrome (GBS). The number of endoneurial macrophages, identified by the monoclonal antibody MAC 387, was increased, compared with the number in 10 cases of axonal neuropathy. Macrophage-associated demyelination was identified in 7 and axonal degeneration in 8 cases. Cytomegalovirus (CMV) genome was not detected with the polymerase chain reaction.
Hughes
R
R
Department of Neurology, United Medical School, Guy's Hospital, London, United Kingdom.
Atkinson
P
P
Coates
P
P
Hall
S
S
Leibowitz
S
S
D000328:Adult; D000368:Aged; D001369:Axons / Q000502:physiology; D003587:Cytomegalovirus / Q000302:isolation & purification*; D003711:Demyelinating Diseases / Q000473:pathology*; D005260:Female; D005814:Genes, Viral / Q000235:genetics; D006801:Humans; D008264:Macrophages / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009410:Nerve Degeneration / Q000502:physiology; D016133:Polymerase Chain Reaction; D011129:Polyradiculoneuropathy / Q000473:pathology*; D013497:Sural Nerve / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology