[Late results of surgical treatment of myasthenia gravis in children].
Thymectomy was carried out in 52 children with the generalized form of myasthenia at the Moscow Regional Research Clinical Institute in 1986-1991. The long-term results were studied in 50 patients in follow-up periods of 6 months to 5 years. The follow-up was studied in all patients, the muscular strength in various groups of muscles was measured according to a 5-point scale, and the function of external respiration, neuromuscular conductivity, and cellular and humoral immunity were studied. After thymectomy the symptoms of myasthenia disappeared completely or diminished significantly, the decrement was 11% on the average instead of 37% as was before the operation, the external respiration values improved, the level of circulating immune complexes and immunoglobulins became normal. The long-term results were appraised according to G. Keanes' scale. Group A was made up of 22 patients, group B of 13, group C of 5, group D of 8, and group E of 2 patients. Thus, the study shows that thymectomy is the most effective method for the treatment of myasthenia in children today.
Tsuman
V G
VG
Nalivkin
A E
AE
Agafonov
B V
BV
Sidorova
O P
OP
Fialkovskiĭ
S Iu
SIu
Cherkesova
Z I
ZI
D000293:Adolescent; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009157:Myasthenia Gravis / Q000503:physiopathology / Q000601:surgery*; D009469:Neuromuscular Junction / Q000502:physiology; D010956:Plasmapheresis; D011182:Postoperative Care; D011300:Preoperative Care; D012119:Respiration / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology; D013934:Thymectomy; D013997:Time Factors
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