[A comparative study of the action of preparations of high- and low-molecular weight heparin on hemostatic indices in vitro and in their intravenous administration to animals].
Low-molecular heparin preparations (a Soviet sample and that manufactured by the Celsus Company) in vitro, added to bovine plasma possess a lower antifactor-II activity, less time of recalcification and partial thromboplastin time as compared to high-molecular heparin of equal concentration (mg/ml) or dose (Units/ml). After intravenous injection of low-molecular heparin preparations to animals in a dose of 50 Units/200 g bw the time of hemorrhage was far less, while anticoagulant activity was lower than in animals given the same dose of high-molecular heparin. Both injection of low-molecular and high-molecular heparin results in a rise of the intensity of non-enzymatic fibrinolysis in the animals' blood plasma.
Kudriashov
B A
BA
Pastorova
V E
VE
Liapina
L A
LA
Kondashevskaia
M V
MV
Azieva
L D
LD
Sukhanov
Iu S
IuS
Fedeniuk
P V
PV
Vasiukov
S E
SE
Cherstvova
L G
LG
D000818:Animals; D001780:Blood Coagulation Tests; D005342:Fibrinolysis / Q000187:drug effects; D006487:Hemostasis / Q000187:drug effects*; D006493:Heparin / Q000008:administration & dosage / Q000494:pharmacology*; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D008970:Molecular Weight; D051381:Rats; D013997:Time Factors
D006495:Heparin, Low-Molecular-Weight; D006493:Heparin
Sravnitel'noe izuchenie deĭstviia preparatov vysoko- i nizkomolekuliarnogo geparina na nekotorye pokazateli gemostaza in vitro i pri vnutrivennom vvedenii zhivotnym.