[Effect of preventive and therapeutical function of jian-pi yi-qi li-shui decoction on cisplatin nephrotoxicity in rats].
The effect of preventive and therapeutical function of Chinese herbs compound prescription Jian-Pi Yi-qi Li-Shui decoction (JPYQLSD) on cisplatin (DDP) and nephrotoxicity of rat. It was carried out that the prescription JPYQLSD had notable result in reducing content of serum urea nitrogen, glucosaminidase, beta 2-microglobulin of the rats (P < 0.05). JPYQLSD also could alleviate inhibition on activity of adenosine triphosphatase (ATP-ase). Pathological examination revealed the protective effect of the JPYQLSD on kidneys of rats. It suggested that JPYQLSD has a good effect on preventive and therapeutical function of Cisplatin (DDP) nephrotoxicity. The mechanism of JPYQLSD was to regulate the energy metabolism of rats.
Cheng
J H
JH
Jiangxi Provincial Tumor Hospital, Nan-chang.
D000818:Animals; D002945:Cisplatin / Q000009:adverse effects*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D000254:Sodium-Potassium-Exchanging ATPase; D002945:Cisplatin