Inhibitory effect of oligoribonucleotide phosphorodithioates against the 3'-exonuclease activity.
Oligoribonucleotides consisted of modified nucleotides at 3'-turmini were chemically synthesized on the solid phase method. Moreover, these analogues were investigated the stability in a prokaryotic cell-free translation system and the resistance against a few kind of nucleases containing 3'-exonuclease activity.
Sakatsume
O
O
Department of Industrial Chemistry, Chiba Institute of Technology, Japan.
Tanaka
H
H
Takaku
H
H
D001483:Base Sequence; D005092:Exonucleases / Q000037:antagonists & inhibitors*; D008969:Molecular Sequence Data; D009843:Oligoribonucleotides / Q000494:pharmacology*; D013873:Thionucleotides / Q000494:pharmacology*
D009843:Oligoribonucleotides; D013873:Thionucleotides; D005092:Exonucleases