title: Iodine-induced subclinical hypothyroidism in euthyroid subjects with a previous episode of amiodarone-induced thyrotoxicosis.
abstract: Amiodarone-induced thyrotoxicosis (AIT) occurs most frequently in patients with underlying thyroid disease and is generally believed to be due to the iodine contamination of amiodarone and iodine released by the metabolism of the drug. We and others have suggested that the thyrotoxicosis may also be secondary to amiodarone-induced thyroiditis. To further determine the etiology of AIT, we administered large doses of iodides [10 drops saturated solution of potassium iodide (SSKI) daily] to 10 euthyroid patients long after an episode of AIT believed to be due at least in part to amiodarone-induced thyroiditis. Six of these 10 patients had an abnormal iodide-perchlorate discharge test before SSKI administration, indicating a subtle defect in the thyroidal organification of iodide. During SSKI administration, 6 patients developed marked iodine-induced basal and/or TRH-stimulated serum TSH elevations, 2 had suppressed basal and TRH-stimulated TSH values, and 2 had normal TSH responses compared to SSKI-treated euthyroid subjects with no history of amiodarone ingestion or thyroid disease. Serum T4 and T3 concentrations remained normal and unchanged during SSKI administration in both the AIT patients and control subjects. These results strongly suggest that excess iodine may not be the cause of the hyperthyroidism associated with amiodarone therapy, especially in those patients with probable amiodarone-induced thyroiditis. Furthermore, like patients with a previous history of subacute thyroiditis and postpartum thyroiditis, the present results suggest that some patients with a previous history of AIT may be at risk to develop hypothyroidism when given excess iodine.
authors.affiliation: Centro per lo Studio, Prevenzione, Diagnosi e Cura delle Tireopatie, Universitá di Parma, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Roti
authors.forename: R
authors.initials: R
authors.lastname: Minelli
authors.forename: E
authors.initials: E
authors.lastname: Gardini
authors.forename: L
authors.initials: L
authors.lastname: Bianconi
authors.forename: G
authors.initials: G
authors.lastname: Gavaruzzi
authors.forename: G
authors.initials: G
authors.lastname: Ugolotti
authors.forename: T M
authors.initials: TM
authors.lastname: Neri
authors.forename: L E
authors.initials: LE
authors.lastname: Braverman
mesh_terms: D000638:Amiodarone / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced* / Q000175:diagnosis; D007455:Iodine / Q000494:pharmacology; D007457:Iodine Radioisotopes; D008875:Middle Aged; D010472:Perchlorates; D011188:Potassium; D017680:Potassium Compounds; D013971:Thyrotoxicosis / Q000139:chemically induced*; D013997:Time Factors
chemical_list: D007457:Iodine Radioisotopes; D010472:Perchlorates; D017680:Potassium Compounds; C009006:potassium perchlorate; D007455:Iodine; D000638:Amiodarone; D011188:Potassium