Induction of feeding by 7-chlorokynurenic acid, a strychnine-insensitive glycine binding site antagonist.
Two experiments examined the involvement of the strychnine-insensitive glycine binding site (SIGBS) of the N-methyl-D-aspartate (NMDA) receptor/channel complex in feeding behavior. The first experiment demonstrated that the SIGBS antagonist, 7-chlorokynurenic acid (7CK), dose-dependently increased food intake in rats without producing significant locomotor deficits or stereotypies. The second experiment showed that D-serine, a SIGBS agonist, dose-dependently antagonized 7CK induced feeding, such that at the highest dose of D-serine used 7CK induced feeding was completely abolished, demonstrating that the effects of 7CK are specific to an action at the SIGBS.
Sorrels
T L
TL
Neuropsychology Department, City University of New York-Queens College, Flushing 11367.
Bostock
E
E
D000704:Analysis of Variance; D000818:Animals; D001259:Ataxia / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects*; D005998:Glycine; D007276:Injections, Intraventricular; D007736:Kynurenic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D051381:Rats; D018009:Receptors, Glycine; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D017981:Receptors, Neurotransmitter / Q000037:antagonists & inhibitors*; D012694:Serine / Q000494:pharmacology; D013331:Strychnine / Q000494:pharmacology*
D018009:Receptors, Glycine; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D012694:Serine; D007736:Kynurenic Acid; D013331:Strychnine; C057013:7-chlorokynurenic acid; D005998:Glycine