title: Recurrent herpetic keratitis during topical acyclovir application.
abstract: Dendritic herpetic keratitis developed in a 49-year-old patient during topical acyclovir treatment. A positive herpes simplex culture was obtained. After acyclovir was replaced by trifluorothymidine and interferon, the dendritic lesion disappeared and herpes simplex culture became negative. Six months later a carcinoma of the larynx was diagnosed. The acyclovir-resistant herpetic keratitis may be associated with the carcinoma because resistant herpes simplex virus strains are predominantly described in patients suffering from immune deficiency.
authors.affiliation: Universitäts-Augenklinik Freiburg, Germany.
authors.forename: J M
authors.initials: JM
authors.lastname: Soriano
authors.forename: J
authors.initials: J
authors.lastname: Funk
authors.forename: P
authors.initials: P
authors.lastname: Janknecht
authors.forename: B
authors.initials: B
authors.lastname: Matz
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use; D016898:Interferon-alpha; D016849:Keratitis, Herpetic / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011994:Recombinant Proteins; D012008:Recurrence; D018139:Simplexvirus / Q000187:drug effects; D014271:Trifluridine / Q000627:therapeutic use
chemical_list: D007370:Interferon Type I; D016898:Interferon-alpha; D009883:Ophthalmic Solutions; D011994:Recombinant Proteins; D014271:Trifluridine; C554129:interferon alfa-2c; D000212:Acyclovir