Influence of free radical scavengers on myeloperoxidase activity and lipid peroxidation in acute skin grafts.
Activated neutrophil granulocytes are an important source of oxygen free radicals in acute skin grafts. Lipid peroxidation and immigration of PMNs, indicating inflammatory mechanisms, affect each other to a variable extent. The effect of the scavengers allopurinol and alpha-D-tocopherol on both lipid peroxidation and neutrophilic infiltration was investigated. A possible mechanism for the superior effect of allopurinol compared to vitamin E was discussed.
Goldstein
R K
RK
Department of Dermatology, University of Wuerzburg, Germany.
Augustin
A
A
Milz
J
J
Burg
G
G
Lutz
J
J
D000493:Allopurinol / Q000494:pharmacology; D000818:Animals; D016166:Free Radical Scavengers; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D009336:Necrosis; D009504:Neutrophils / Q000201:enzymology / Q000473:pathology; D009195:Peroxidase / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D016038:Skin Transplantation / Q000009:adverse effects / Q000473:pathology / Q000502:physiology*; D014810:Vitamin E / Q000494:pharmacology
D016166:Free Radical Scavengers; D014810:Vitamin E; D000493:Allopurinol; D009195:Peroxidase