title: Postoperative venous thromboembolism and brain tumors: Part III. Biochemical profile.
abstract: The plasminogen activator activity of 31 human brain tumor samples was assessed and the results correlated with clinical parameters and the postoperative occurrence of venous thrombosis. A significant negative correlation was found between plasminogen activator activity and venous thrombosis (P = 0.02), while positive correlations were observed between plasminogen activator activity and peritumoral brain edema (P = 0.03) and alpha 2 antiplasmin measured in the systemic circulation (P = 0.01). Tissue plasminogen activator was found in higher concentrations in meningioma tissue but did not correlate significantly with the occurrence of venous thrombosis. The results of this study suggest a local enzymatic degradation effect of plasminogen activator on thrombogenic substances present in the brain tumor and/or its environment.
authors.affiliation: Department of Neurosurgery, University of Cincinnati, Ohio.
authors.forename: R
authors.initials: R
authors.lastname: Sawaya
authors.forename: R F
authors.initials: RF
authors.lastname: Highsmith
mesh_terms: D001780:Blood Coagulation Tests; D001929:Brain Edema / Q000209:etiology / Q000503:physiopathology; D001932:Brain Neoplasms / Q000097:blood / Q000737:chemistry / Q000150:complications* / Q000556:secondary / Q000601:surgery; D004198:Disease Susceptibility; D005909:Glioblastoma / Q000097:blood / Q000737:chemistry / Q000150:complications* / Q000601:surgery; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000097:blood / Q000737:chemistry / Q000150:complications* / Q000601:surgery; D008579:Meningioma / Q000097:blood / Q000737:chemistry / Q000150:complications* / Q000601:surgery; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D010960:Plasminogen Activators / Q000032:analysis*; D011183:Postoperative Complications / Q000209:etiology* / Q000503:physiopathology; D011446:Prospective Studies; D013923:Thromboembolism / Q000209:etiology* / Q000503:physiopathology
chemical_list: D009363:Neoplasm Proteins; D010960:Plasminogen Activators