Effects of alprazolam on the development of MTV-induced mammary tumors in female mice under stress.
Female C3H/He mice carrying the mammary tumor virus (MTV) were monitored for mammary tumor incidence and latent periods while subjected to a daily intraperitoneal (i.p.) injection of placebo or alprazolam (1 mg/kg per day). Although all of the mice were potential candidates for MTV-induced breast cancer, those injected with alprazolam were partially protected against adverse effects of stress induced by the daily administration of placebo.
Freire-Garabal
M
M
Department of Pharmacology, School of Medicine, University of Santiago, Spain.
Núñez
M J
MJ
Balboa
J L
JL
Suárez
J A
JA
Belmonte
A
A
D000367:Age Factors; D000525:Alprazolam / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000209:etiology* / Q000517:prevention & control; D008324:Mammary Tumor Virus, Mouse; D051379:Mice; D008809:Mice, Inbred C3H; D013312:Stress, Physiological / Q000150:complications*; D013997:Time Factors; D014412:Tumor Virus Infections
D000525:Alprazolam