Granulocyte migration in vivo and in vitro in healthy children of parents with infectious asthma.
Our study was carried out on 28 healthy children aged 6-11 years (mean = 9 years) with at least one parent having infectious asthma, and 13 children aged 7-14 years (mean = 9 years), both of whose parents had infectious asthma. The age of the affected parents was 26-45 years (mean = 36 years). The control group comprised 20 healthy subjects aged 25-37 years (mean = 32 years) and 20 healthy children aged 6-14 years (mean = 9 years) with no family history of atopic diseases. In all subjects, the test of granulocyte migration in vitro was carried out using the method of Clausen, modified by us. The in vivo test was performed according to the Southam method. The results of our investigations demonstrate a defect of granulocyte migration in patients with infectious bronchial asthma. In healthy children, both of whose parents had infection, the migration of the granulocytes was impaired.
Matusiewicz
R
R
First Department of Internal Diseases, Grochow Hospital, Warsaw, Poland.
Grzybowski
A
A
Urbankowska
B
B
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology*; D002465:Cell Movement / Q000235:genetics; D002648:Child; D005260:Female; D006098:Granulocytes / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D012141:Respiratory Tract Infections / Q000150:complications