Sub-acute underfeeding but not acute starvation reduces noradrenaline induced thermogenesis in the conscious rat.
The thermogenic responses to noradrenaline have been studied during food restriction in conscious rats. Acute starvation for 16-18 h reduced the body weight by 3% but not the resting metabolic rate or the increase in metabolic rate induced by noradrenaline, compared to control rats. Sub-acute underfeeding (eight days) with 50% of the control daily intake decreased body weight by 15% and was associated with a significant (P less than 0.05) reduction in resting metabolic rate and a significant (P less than 0.01) suppression of the thermogenic response to noradrenaline. Thus, food restriction reduces the thermogenic responses to noradrenaline, but only after a certain duration of restricted intake.
Siyamak
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Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham, UK.
Macdonald
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IA
D000208:Acute Disease; D000818:Animals; D001481:Basal Metabolism; D001833:Body Temperature Regulation / Q000187:drug effects*; D004734:Energy Metabolism; D005508:Food Deprivation / Q000502:physiology*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D013217:Starvation / Q000378:metabolism*; D015431:Weight Loss
D009638:Norepinephrine