Effect of sumatriptan, a new selective 5HT1-like agonist, on liquid gastric emptying in man.
Paired studies were carried out on 12 healthy male subjects to compare the effect of intravenous doses of the 5-HT1-like agonist sumatriptan (GR43175; 3 mg), 10 mg metoclopramide and saline control on the rate of gastric emptying of a radiolabelled liquid test-meal. Intravenous administration of metoclopramide accelerated gastric emptying by decreasing the lag period, while intravenous administration of sumatriptan delayed gastric emptying by increasing the lag period. The observation that sumatriptan causes a delay in gastric emptying in normal healthy volunteers, but relieves nausea and vomiting during migraine attacks, suggests that sumatriptan may be acting via a central mechanism to relieve symptoms of nausea and vomiting associated with migraine.
Houghton
L A
LA
Sub-Department of Gastrointestinal Physiology and Nutrition, University of Sheffield, UK.
Fowler
P
P
Keene
O N
ON
Read
N W
NW
D000328:Adult; D004311:Double-Blind Method; D005223:Fats / Q000378:metabolism; D015902:Gamma Cameras; D005746:Gastric Emptying / Q000187:drug effects*; D006207:Half-Life; D006801:Humans; D007211:Indoles / Q000009:adverse effects / Q000494:pharmacology*; D007262:Infusions, Intravenous; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology; D008881:Migraine Disorders / Q000150:complications / Q000188:drug therapy; D009325:Nausea / Q000150:complications / Q000188:drug therapy; D017366:Serotonin Receptor Agonists / Q000009:adverse effects / Q000494:pharmacology*; D013449:Sulfonamides / Q000009:adverse effects / Q000494:pharmacology*; D018170:Sumatriptan; D013997:Time Factors; D014839:Vomiting / Q000150:complications / Q000188:drug therapy
D005223:Fats; D007211:Indoles; D017366:Serotonin Receptor Agonists; D013449:Sulfonamides; D018170:Sumatriptan; D008787:Metoclopramide