Bacterial chemistry. VI. Biological activities and cytotoxicity of 1,3-dihydro-2H-indol-2-one derivatives.
The biosynthetic pigment from Chromobacterium violaceum BB-78, 1,3-dihydro-2H-indol-2-one and its derivatives exhibit biological activities such as antimicrobial action, low hemolytic effects on red blood cells and in vitro trypanocide activity. A relatively high cytotoxicity on V-79 hamster fibroblast cells of the biosynthetic pigment was found, although with the methylol derivative the toxicity was almost eliminated. The methylol derivative exhibited similar toxicity as Nifurtimox, a known, commercial trypanocide compound.
Haun
M
M
Departamento de Bioquímica, Instituto de Biología, Universidade Estadual de Campinas, S. P., Brazil.
Pereira
M F
MF
Hoffmann
M E
ME
Joyas
A
A
Campos
V
V
Filardi
L D
LD
de Castro
S L
SL
Duran
N
N
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000633:toxicity*; D001419:Bacteria / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002861:Chromobacterium / Q000254:growth & development / Q000378:metabolism*; D006224:Cricetinae; D005347:Fibroblasts / Q000187:drug effects; D006461:Hemolysis; D007211:Indoles / Q000302:isolation & purification / Q000633:toxicity*; D008826:Microbial Sensitivity Tests; D009547:Nifurtimox / Q000633:toxicity; D010860:Pigments, Biological / Q000302:isolation & purification / Q000633:toxicity*; D014349:Trypanosoma cruzi / Q000187:drug effects / Q000254:growth & development
D000900:Anti-Bacterial Agents; D007211:Indoles; D010860:Pigments, Biological; D009547:Nifurtimox