The effect of lidocaine on oxygen free radical production by polymorphonuclear neutrophils.
During myocardial ischemia and subsequent reperfusion, activation of polymorphonuclear neutrophils occurs and results in an increased production of oxygen free radicals that participate in the generation of reperfusion arrhythmias. We investigated the effect of antiarrhythmic drug lidocaine on oxygen free radicals production by activated neutrophils in vitro with a chemiluminescence assay. Lidocaine reduced lucigenin-amplified chemiluminescence related to the superoxide anion production but failed to affect hydrogen-peroxide dependent luminol chemiluminescence.
Siminiak
T
T
Academy of Medicine, Institute of Internal Medicine, Poznan, Poland.
Wysocki
H
H
D005609:Free Radicals; D006861:Hydrogen Peroxide / Q000378:metabolism*; D008012:Lidocaine / Q000494:pharmacology*; D008163:Luminescent Measurements; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D015054:Zymosan / Q000494:pharmacology
D005609:Free Radicals; D013481:Superoxides; D015054:Zymosan; D008012:Lidocaine; D006861:Hydrogen Peroxide; D013755:Tetradecanoylphorbol Acetate