title: Changes of neuropeptides and their receptors in experimental stroke gerbil brains.
abstract: Eight kinds of neuropeptides and four kinds of neuropeptide receptors were examined in the right and left hemispheres of mongolian gerbils after unilateral carotid ligation-induced stroke and in normal controls. Five hours after ligation of the right common carotid artery, beta-endorphin concentration in the right hemisphere (ischemic side) of the stroke group was significantly increased compared with that in the contralateral hemisphere (non-ischemic side), but there were no differences between sides in other neuropeptides either with or without stroke. Furthermore, although there were no differences in [3H]naloxone binding, [3H]thyrotropin-releasing hormone binding or 125I-vasoactive intestinal polypeptide binding in the brain in this model of stroke, [3H]enkephalin binding was significantly lower on the ischemic side than on the non-ischemic side in the stroke group. These results suggest that increased activity in the beta-endorphinergic system in the brain might be partly caused by ischemic brain failure.
authors.affiliation: Department of Neurochemistry, Okayama University Medical School, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Haba
authors.forename: N
authors.initials: N
authors.lastname: Ogawa
authors.forename: M
authors.initials: M
authors.lastname: Asanuma
authors.forename: H
authors.initials: H
authors.lastname: Hirata
authors.forename: Y H
authors.initials: YH
authors.lastname: Sora
authors.forename: A
authors.initials: A
authors.lastname: Mori
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D002544:Cerebral Infarction / Q000378:metabolism*; D004723:Endorphins / Q000378:metabolism; D005849:Gerbillinae; D009270:Naloxone / Q000378:metabolism; D009479:Neuropeptides / Q000032:analysis*; D017981:Receptors, Neurotransmitter / Q000032:analysis*; D011957:Receptors, Opioid / Q000378:metabolism
chemical_list: D004723:Endorphins; D009479:Neuropeptides; D017981:Receptors, Neurotransmitter; D011957:Receptors, Opioid; D009270:Naloxone