Application of monoclonal antibody panels in the virological and epidemiological review of poliomyelitis in Poland, 1981-1990.
Monoclonal antibody panels developed to differentiate vaccine-derived and wild-type strains of polio-viruses were applied to isolates from cases of paralytic poliomyelitis, non-paralytic poliomyelitis, and healthy excreters of poliovirus from Poland. All isolates from poliomyelitis cases were shown to be vaccine-derived, as were most other strains. However, two strains associated with meningitis had wild-type antigenic phenotypes and, as shown by partial genomic sequencing, wild-type genotypes. Correlation of laboratory and epidemiological data suggested that residual cases of paralytic poliomyelitis in Poland between 1981 and 1990 were vaccine-related. Study of the non-paralytic cases, however, helped identify the circulation of endemic wild-type viruses in a well-vaccinated community.
Jarzabek
Z
Z
Department of Virology, National Institute of Hygiene, Warsaw, Poland.
Zabicka
J
J
John
A
A
Howlett
J
J
Dunn
G
G
Wood
D J
DJ
D000328:Adult; D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral / Q000302:isolation & purification*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011044:Poland / Q000453:epidemiology; D011051:Poliomyelitis / Q000453:epidemiology / Q000382:microbiology* / Q000635:transmission; D017955:Poliovirus / Q000145:classification / Q000276:immunology*; D011055:Poliovirus Vaccine, Oral / Q000009:adverse effects
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D011055:Poliovirus Vaccine, Oral