Viral thymidine kinases and their relatives.
Thymidine kinases were described for cellular life long before it was shown that they could also be encoded by viruses, but the viral thymidine kinase genes were the first to be sequenced. These enzymes have been extraordinarily useful to the researcher, serving first to help label DNA, then to get thymidine analogs incorporated into DNA for therapeutic and other purposes and more recently to move genes from one genome to another. Knowledge of the nucleotide and amino acid sequences of these enzymes has allowed some deductions about their possible three-dimensional structure, as well as the location on the polypeptide of various functions; it has also allowed their classification into two main groups: the herpesviral thymidine/eukaryotic deoxycytidine kinases and the poxviral and cellular thymidine kinases; the relationships of the mitochondrial enzyme are still not clear.
Gentry
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Department of Microbiology, University of Mississippi Medical Center, Jackson 39216-4505.
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008928:Mitochondria / Q000201:enzymology; D008969:Molecular Sequence Data; D009701:Nucleoside-Diphosphate Kinase / Q000378:metabolism / Q000502:physiology; D011212:Poxviridae / Q000201:enzymology; D016415:Sequence Alignment; D018139:Simplexvirus / Q000201:enzymology*; D013937:Thymidine Kinase / Q000378:metabolism / Q000502:physiology*
D013937:Thymidine Kinase; D009701:Nucleoside-Diphosphate Kinase