title: [A comparative study of the action of preparations of high- and low-molecular weight heparin on hemostatic indices in vitro and in their intravenous administration to animals].
abstract: Low-molecular heparin preparations (a Soviet sample and that manufactured by the Celsus Company) in vitro, added to bovine plasma possess a lower antifactor-II activity, less time of recalcification and partial thromboplastin time as compared to high-molecular heparin of equal concentration (mg/ml) or dose (Units/ml). After intravenous injection of low-molecular heparin preparations to animals in a dose of 50 Units/200 g bw the time of hemorrhage was far less, while anticoagulant activity was lower than in animals given the same dose of high-molecular heparin. Both injection of low-molecular and high-molecular heparin results in a rise of the intensity of non-enzymatic fibrinolysis in the animals' blood plasma.
authors.forename: B A
authors.initials: BA
authors.lastname: Kudriashov
authors.forename: V E
authors.initials: VE
authors.lastname: Pastorova
authors.forename: L A
authors.initials: LA
authors.lastname: Liapina
authors.forename: M V
authors.initials: MV
authors.lastname: Kondashevskaia
authors.forename: L D
authors.initials: LD
authors.lastname: Azieva
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Sukhanov
authors.forename: P V
authors.initials: PV
authors.lastname: Fedeniuk
authors.forename: S E
authors.initials: SE
authors.lastname: Vasiukov
authors.forename: L G
authors.initials: LG
authors.lastname: Cherstvova
mesh_terms: D000818:Animals; D001780:Blood Coagulation Tests; D005342:Fibrinolysis / Q000187:drug effects; D006487:Hemostasis / Q000187:drug effects*; D006493:Heparin / Q000008:administration & dosage / Q000494:pharmacology*; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D008970:Molecular Weight; D051381:Rats; D013997:Time Factors
chemical_list: D006495:Heparin, Low-Molecular-Weight; D006493:Heparin
vernacular_title: Sravnitel'noe izuchenie deĭstviia preparatov vysoko- i nizkomolekuliarnogo geparina na nekotorye pokazateli gemostaza in vitro i pri vnutrivennom vvedenii zhivotnym.