[Effect of combined use of chemotherapeutic agents and hematopor--phyrin derivative (HPD) on human gastric cancer cell line in vitro].
The interaction between (HPD) photodynamic therapy and 4 cytotoxic drugs on human gastric poorly differentiated mucinous adenocarcinoma cell line MGc 80-3 was studied. As the cells were blocked by 4 cytotoxic drugs (vincristine, mitomycin, bleomycin A5 and 5-Fluorouracil) in different phases, HPD was located in different sites in these cells. The photodynamic effect was potentiated when the cytotoxic drugs were administered before but not after the application of HPD plus light. The synchronous cells would absorb HPD more than the asynchronous cells.
Niu
M Y
MY
Beijing Institute for Cancer Research.
D002288:Adenocarcinoma, Mucinous / Q000473:pathology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004357:Drug Synergism; D005472:Fluorouracil / Q000494:pharmacology; D017324:Hematoporphyrin Derivative / Q000494:pharmacology*; D006414:Hematoporphyrin Photoradiation; D006801:Humans; D008937:Mitomycins / Q000494:pharmacology; D013274:Stomach Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014750:Vincristine / Q000494:pharmacology
D000970:Antineoplastic Agents; D008937:Mitomycins; D014750:Vincristine; D017324:Hematoporphyrin Derivative; D005472:Fluorouracil