title: Cytogenetics of a case of eccrine spiradenoma.
abstract: A cytogenetic study of an eccrine spiradenoma and two lymph node metastases, with a growth pattern and microscopic appearance typical for benign eccrine spiradenoma, revealed a 46,XY-5,del(16)(q22),+mar(t(?;5)(?::5q13----5qter)) karyotype. The finding of the same abnormal karyotype in the tumor and the metastases suggests a relationship between the chromosomal abnormalities and the clinical malignant behavior of this morphologic benign tumor.
authors.affiliation: Department of Medical Genetics, University of Groningen, The Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: Dijkhuizen
authors.forename: E
authors.initials: E
authors.lastname: van den Berg
authors.forename: P G
authors.initials: PG
authors.lastname: Nikkels
authors.forename: H J
authors.initials: HJ
authors.lastname: Hoekstra
authors.forename: B
authors.initials: B
authors.lastname: de Jong
mesh_terms: D006607:Adenoma, Sweat Gland / Q000235:genetics* / Q000473:pathology; D000368:Aged; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D006801:Humans; D007621:Karyotyping; D008207:Lymphatic Metastasis; D008297:Male; D008677:Metaphase; D013899:Thoracic Neoplasms / Q000235:genetics* / Q000473:pathology