[The properties of the brain dopamine and GABA receptors in rats with chronic alcoholic intoxication with different ethanol withdrawal times].
Marked changes in dopamine and GABA receptors in the brain of rats with chronic alcohol intoxication were registered 48 h and 3 months after ethanol withdrawal. The changes in dopamine receptors characterized by the increased number of the sites of binding with ligand (Bmax) were most pronounced 48 h after ethanol withdrawal. In 3 months the properties of these receptors tended toward recovery. The changes in GABA receptors also manifested by the increase in Bmax become further pronounced 3 months after ethanol withdrawal.
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D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D000431:Ethanol / Q000009:adverse effects*; D008297:Male; D011869:Radioligand Assay; D051381:Rats; D017208:Rats, Wistar; D011954:Receptors, Dopamine / Q000032:analysis / Q000187:drug effects*; D011963:Receptors, GABA-A / Q000032:analysis / Q000187:drug effects*; D013375:Substance Withdrawal Syndrome / Q000378:metabolism*; D013997:Time Factors
D011954:Receptors, Dopamine; D011963:Receptors, GABA-A; D000431:Ethanol
Svoĭstva dofaminovykh i GAMK-retseptorov mozga u krys s khronicheskoĭ alkogol'noĭ intoksikatsieĭ pri razlichnykh srokakh lisheniia étanola.