title: GISSI-3 study protocol on the effects of lisinopril, of nitrates, and of their association in patients with acute myocardial infarction.
abstract: The role of thrombolysis in the acute phase of myocardial infarction (AMI) has been definitely established in terms of mortality and ventricular function, as has the equivalence of different thrombolytic agents. The Second Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI-2) trial showed that a large number of patients have either clinical heart failure or severe left ventricular damage on discharge from the hospital, with a large risk of death and poor prospects in terms of quality of life. Additional measures to limit ventricular damage are therefore essential to reducing morbidity. The GISSI-3 study protocol on the effects of lisinopril and nitrates, used alone or in combination, in patients with AMI is described in detail.
authors.affiliation: Associazione Nazionale Medici Cardiologi Ospedalieri and Istituto di Richerche Farmacologiche Mario Negri, Milano, Italy
mesh_terms: D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002985:Clinical Protocols; D004151:Dipeptides / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000517:prevention & control; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000517:prevention & control; D007258:Informed Consent; D007558:Italy / Q000453:epidemiology; D017706:Lisinopril; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000401:mortality; D005996:Nitroglycerin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010865:Pilot Projects; D015996:Survival Rate; D015912:Thrombolytic Therapy; D016896:Treatment Outcome; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D004151:Dipeptides; D004338:Drug Combinations; D017706:Lisinopril; D005996:Nitroglycerin