ACTH accelerates the attenuation of alpha 2-adrenoceptors response in nucleus accumbens following chronic desipramine.
The inclusion of clonidine (CLO) induced a dose-dependent reduction of K(+)-evoked [3H] dopamine ([3H]DA) release in slices from rat nucleus accumbens. This inhibition was clearly attenuated in animals previously administered desipramine daily (DMI, 10 mg/kg i.p.) during 21 days, but not in rats submitted to a persistent treatment with DMI during 10 days. However, the coadministration of adrenocorticotrophic hormone (ACTH, 50 IU/kg s.c.) and DMI (10 mg/kg i.p.) for 10 days provoked a clear decrease in the inhibition produced by alpha 2-adrenoceptor stimulation, while ACTH alone had no effect. These results may indicate that ACTH accelerates the onset of DMI-induced adaptive changes on central alpha 2-adrenoceptor in the mesolimbic area.
Volosin
M
M
Dept. of Pharmacology, Faculty of Chemical Sciences, National University of Córdoba, Argentina.
Cancela
L M
LM
Molina
V A
VA
D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D003000:Clonidine / Q000494:pharmacology; D003891:Desipramine / Q000008:administration & dosage / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D004347:Drug Interactions; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects*; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*; D014316:Tritium
D011942:Receptors, Adrenergic, alpha; D014316:Tritium; D000324:Adrenocorticotropic Hormone; D003000:Clonidine; D011188:Potassium; D003891:Desipramine; D004298:Dopamine