[Pharmacological intervention in experimental multiple organ failure in rats].
This paper presents a primary study of the treatment of experimental multiple system organ failure (MSOF) in rats. The rats were pretreated with xanthine oxidase inhibitor allopurinol, the energy metabolism regulator fructose-1,6-diphosphate (FDP) and purified Chinese herbal medicine polydatin. The incidence of MSOF decreased from 71.4% in the untreated group to 35.7%, 47.1% and 16.7% in treated groups, respectively, while the mean survival time was prolonged to 38.5h, 30.2h and 41.7h in treated groups, respectively, as compared with 26.4h in the untreated group. In addition to the known antioxidant effect of the allopurinol, this study also suggests that FDP and polydatin enhance the capacity of antioxidtion.
Huang
Q B
QB
Department of Pathophysiology, First Medical College of PLA.
D000493:Allopurinol / Q000627:therapeutic use*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D005609:Free Radicals; D006597:Fructose-Bisphosphatase / Q000627:therapeutic use*; D005960:Glucosides / Q000627:therapeutic use*; D005979:Glutathione Peroxidase / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009102:Multiple Organ Failure / Q000188:drug therapy / Q000517:prevention & control*; D010100:Oxygen; D051381:Rats; D011919:Rats, Inbred Strains; D013267:Stilbenes / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D005609:Free Radicals; D005960:Glucosides; D013267:Stilbenes; D008315:Malondialdehyde; D000493:Allopurinol; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D006597:Fructose-Bisphosphatase; D010100:Oxygen; C058229:polydatin