[Role of metalloproteases of extracellular matrix in the premature rupture of fetal membranes: a novel physiopathogenic model].
Experimental proofs are presented, that involve the participation of the metalloproteinases family, of extracellular matrix in the genesis of premature rupture of membranes. The expression of this group of enzymes, which presents in normal conditions of labor appears in the RPM without relation with gestational age. This phenomenon is not presented as an isolated example of participation of metalloproteinases in events related to labor and delivery, as is very well known its participation in maturation of uterine cervix preceding product expulsion, and that consists in similar mechanisms to the ones now chosen for the maturation of fetal membranes. The working hypothesis in pathologic conditions, implies, then, the activation of a normal system in an inadequate moment that results in premature rupture of membranes.
Vadillo Ortega
F
F
Hernández
A
A
Meraz Cruz
N
N
Monzón Bordonaba
F A
FA
Beltrán Montoya
J
J
Soto Martinez
J
J
Bustos Lopez
H
H
D000653:Amniotic Fluid / Q000201:enzymology; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000209:etiology*; D006801:Humans; D008666:Metalloendopeptidases / Q000378:metabolism*; D003012:Microbial Collagenase / Q000378:metabolism; D008954:Models, Biological; D011247:Pregnancy
D016326:Extracellular Matrix Proteins; D008666:Metalloendopeptidases; D003012:Microbial Collagenase
Participación de las metaloproteasas de matriz extracelular en la ruptura prematura de membranas fetales: un modelo fisiopatogénico novedoso.