Immunological cross-reactivity between outer membrane pore proteins of Campylobacter jejuni and Escherichia coli.
Immunocrossreactivity between the major outer membrane protein (MOMP) of Campylobacter jejuni 85H and the OmpC porin of Escherichia coli K-12 was observed. These results indicate that a common antigenic domain is conserved in both MOMP and OmpC. This antigenic region is detected only after a 96 degrees C treatment suggesting that it is buried in the native conformation of the respective porins. In addition, differences were observed between the major outer membrane proteins from various C. jejuni strains. About 60% of the C. jejuni pathogenic strains tested contained a protein exhibiting a similar electrophoretic profile to the 85H porin.
Kervella
M
M
Laboratoire de Bactériologie, Faculté de Médecine, Necker-Enfants Malades, Paris, France.
Fauchère
J L
JL
Fourel
D
D
Pagès
J M
JM
D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000276:immunology*; D016123:Campylobacter jejuni / Q000235:genetics / Q000276:immunology*; D003429:Cross Reactions; D004926:Escherichia coli / Q000235:genetics / Q000276:immunology*; D005798:Genes, Bacterial; D018272:Porins; D013045:Species Specificity
D001425:Bacterial Outer Membrane Proteins; D018272:Porins