Herpes simplex virus type 2 infection, syphilis, and hepatitis B virus infection in Haitian women with human immunodeficiency virus type 1 and human T lymphotropic virus type I infections. The Johns Hopkins University (JHU)/Centre pour le Developpement et la Santé (CDS) HIV Study Group.
Antibodies to herpes simplex virus type 2 (HSV-2), antibodies to hepatitis B virus (HBV) core antigen (anti-HBc), and VDRL antibodies (serologic evidence of syphilis) were evaluated in women known to be infected with human immunodeficiency virus type 1 (HIV-1) (n = 95) or human T lymphotropic virus type I (HTLV-I) (n = 45) and controls (n = 89). HIV-1-seropositive women were more likely than controls to have antibodies to HSV-2 (88% vs. 54%; P less than .001), anti-HBc (67% vs. 43%; P = .008), and VDRL antibodies (21% vs. 8%; P = .02). Similarly, HTLV-I-seropositive women were more likely than controls to have antibodies to HSV-2 (82% vs. 54%; P = .003) and anti-HBc (67% vs. 43%; P = .008). There was no evidence that HIV-1 or HTLV-I predisposed to chronic hepatitis B virus infection. The stronger associations between HIV-1 and HTLV-I with HSV-2 than the associations with syphilis or HBV are consistent with the hypothesis that recurrent disruptions of mucous membranes caused by HSV-2 infections predispose to sexual transmission of HIV-1 and HTLV-I.
Boulos
R
R
CDS, Port-au-Prince, Haiti.
Ruff
A J
AJ
Nahmias
A
A
Holt
E
E
Harrison
L
L
Magder
L
L
Wiktor
S Z
SZ
Quinn
T C
TC
Margolis
H
H
Halsey
N A
NA
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000914:Antibodies, Viral / Q000097:blood; D005260:Female; D015483:HIV Antibodies / Q000097:blood; D015658:HIV Infections / Q000150:complications*; D015497:HIV-1; D015481:HTLV-I Antibodies / Q000097:blood; D015490:HTLV-I Infections / Q000150:complications*; D006205:Haiti / Q000453:epidemiology; D006509:Hepatitis B / Q000150:complications / Q000453:epidemiology*; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006561:Herpes Simplex / Q000150:complications / Q000453:epidemiology*; D006801:Humans; D015995:Prevalence; D018139:Simplexvirus / Q000276:immunology; D013587:Syphilis / Q000150:complications / Q000453:epidemiology*; D013588:Syphilis Serodiagnosis
D000914:Antibodies, Viral; D015483:HIV Antibodies; D015481:HTLV-I Antibodies; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens