In vitro and in vivo activities of sparfloxacin, other quinolones, and tetracyclines against Chlamydia trachomatis.
Sparfloxacin was more potent than other quinolones (tosufloxacin, lomefloxacin, ciprofloxacin, ofloxacin, fleroxacin, enoxacin, and norfloxacin) and as potent as minocycline and doxycycline in activity against Chlamydia trachomatis in vitro and in vivo. Sparfloxacin was more bactericidal than minocycline against C. trachomatis D/UW-3/Cx.
Nakata
K
K
Department of Urology, School of Medicine, Kobe University, Japan.
Maeda
H
H
Fujii
A
A
Arakawa
S
S
Umezu
K
K
Kamidono
S
S
D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002690:Chlamydia Infections / Q000188:drug therapy; D002692:Chlamydia trachomatis / Q000187:drug effects*; D024841:Fluoroquinolones; D051379:Mice; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000627:therapeutic use*; D013754:Tetracyclines / Q000627:therapeutic use*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D013754:Tetracyclines; C061363:sparfloxacin