[The relationship between carcinoembryonic antigen (CEA) expression and histogenesis of gastric cancer (application of immunohistochemical and mucin histochemical techniques)].
The distribution of CEA and mucin in gastric specimens of 134 cases was examined by immunohistochemical and mucin histochemical techniques. The results showed that in 85.58% of the gastric cancers CEA was positive, including all mucinous adenocarcinomas, signet-ring cell carcinomas and papillary adenocarcinomas. In tubular adenocarcinoma, there was a tendency of increased expression of CEA with the degree of cell differentiation. The positive rate of CEA in intestinal type of gastric cancer was higher than that in gastric type and stem cell type. Intestinal metaplasia with colonic type sulphomucin had a higher positive rate than that without sulphomucin. The positive rate of CEA in cancers secreting sulfomucin was higher than that in cancers without sulfomucin. It suggested that gastric cancers expressing CEA was histogenetically related to colonic type intestinal metaplasia and cancers without CEA expression might be evolved from gastric proper epithelium.
Wu
J F
JF
Anhui Medical University, Hefei.
D000230:Adenocarcinoma / Q000276:immunology / Q000378:metabolism*; D002288:Adenocarcinoma, Mucinous / Q000276:immunology / Q000378:metabolism*; D000231:Adenocarcinoma, Papillary / Q000276:immunology / Q000378:metabolism; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D009077:Mucins / Q000032:analysis*; D013274:Stomach Neoplasms / Q000276:immunology / Q000378:metabolism*
D002272:Carcinoembryonic Antigen; D009077:Mucins