The effect of arsenate and vanadate ions on the critical cell volume of bovine erythrocytes.
Arsenate, used as an inhibitor of glycolysis, decreases the critical cell volume of erythrocytes, whereas orthovanadate, used as an accelerator of dephosphorylation of phosphatidyl-inositol-4,5-biphosphate, exerts an opposite effect. The ATP-dependent changes of the critical cell volume do not depend on the phosphorylation state of phosphatidylinositol. An interaction of the membrane skeleton with the lipid-protein matrix has been proposed as a regulation mechanism of the critical cell volume of erythrocytes.
Mosior
M
M
Institute of Physics, Technical University of Wrocław, Poland.
Krawczak-Sadowska
T
T
Wróbel
A
A
Białas
W A
WA
Gomułkiewicz
J
J
D000818:Animals; D001149:Arsenates / Q000494:pharmacology*; D002417:Cattle; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects; D066298:In Vitro Techniques; D008051:Lipid Bilayers / Q000097:blood; D019269:Phosphatidylinositol 4,5-Diphosphate; D018129:Phosphatidylinositol Phosphates / Q000097:blood; D010766:Phosphorylation / Q000187:drug effects; D014638:Vanadates / Q000494:pharmacology*
D001149:Arsenates; D008051:Lipid Bilayers; D019269:Phosphatidylinositol 4,5-Diphosphate; D018129:Phosphatidylinositol Phosphates; D014638:Vanadates; C025657:arsenic acid