title: [Wound healing by homeopathic silica dilutions in mice].
abstract: Highly diluted solutions of silica are widely used in homeopathic medicine to treat lesions such as chronic wounds, ulcers, and abscesses. We tested the therapeutic effects of homeopathic dilutions of silica on induced chronic wounds. Holes were made in the ears of mice by dental wire, which then remained hanging from the ear to cause persistent mechanical irritation. In each experiment 3 or 4 groups of 10 mice each were treated by adding homeopathic dilutions of silica (10(-10), 10(-60), 10(-400)) and of saline (10(-10), respectively, to the drinking water of the mice for 4-20 days. The size of the wound holes was measured every second day (grades 0-4) and/or by an objective image analysis system. The results showed that in 7/11 experiments the ear holes of the silica-treated animals were significantly smaller (p less than 0.05-0.001) and healed faster than in those treated with saline. Also the therapeutic effect increased progressively with increase in dilution of the silica (10(-10) less than 10(-60) less than 10(-400)). These results show that homeopathic dilutions of silica (even well beyond Avogadro's number) clearly have a therapeutic effect on wound healing and that our experimental model for studying wound healing is a very useful tool for such studies.
authors.affiliation: Ruth Ben-Ari Institute of Clinical Immunology, Kaplan Hospital, Rehovot.
authors.forename: M
authors.initials: M
authors.lastname: Oberbaum
authors.forename: R
authors.initials: R
authors.lastname: Markovits
authors.forename: Z
authors.initials: Z
authors.lastname: Weisman
authors.forename: A
authors.initials: A
authors.lastname: Kalinkevits
authors.forename: Z
authors.initials: Z
authors.lastname: Bentwich
mesh_terms: D000818:Animals; D004431:Ear, External / Q000293:injuries*; D006705:Homeopathy; D051379:Mice; D008954:Models, Biological; D012822:Silicon Dioxide / Q000008:administration & dosage / Q000627:therapeutic use*; D012996:Solutions; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D012996:Solutions; D012822:Silicon Dioxide