title: The DNA sequence of equine herpesvirus-1.
abstract: The complete DNA sequence was determined of a pathogenic British isolate of equine herpesvirus-1, a respiratory virus which can cause abortion and neurological disease. The genome is 150,223 bp in size, has a base composition of 56.7% G + C, and contains 80 open reading frames likely to encode protein. Since four open reading frames are duplicated in the major inverted repeat, two are probably expressed as a spliced mRNA, and one may contain an internal transcriptional promoter, the genome is considered to contain 76 distinct genes. The genes are arranged collinearly with those in the genomes of the two previously sequenced alphaherpesviruses, varicella-zoster virus, and herpes simplex virus type-1, and comparisons of predicted amino acid sequences allowed the functions of many equine herpesvirus 1 proteins to be assigned.
authors.affiliation: Institute of Virology, University of Glasgow, United Kingdom.
authors.forename: E A
authors.initials: EA
authors.lastname: Telford
authors.forename: M S
authors.initials: MS
authors.lastname: Watson
authors.forename: K
authors.initials: K
authors.lastname: McBride
authors.forename: A J
authors.initials: AJ
authors.lastname: Davison
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D002874:Chromosome Mapping; D005814:Genes, Viral / Q000235:genetics; D016679:Genome, Viral; D006564:Herpesviridae / Q000235:genetics; D006566:Herpesviridae Infections / Q000235:genetics; D004861:Herpesvirus 1, Equid / Q000235:genetics* / Q000472:pathogenicity; D006736:Horses; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D006113:United Kingdom; D014764:Viral Proteins / Q000235:genetics
chemical_list: D014764:Viral Proteins