Epidermodysplasia verruciformis as a model of human papillomavirus-induced genetic cancers: the role of local immunosurveillance.
Epidermodysplasia verruciformis (EV) presents a genetically determined, unusual susceptibility to infection with EV-specific human papillomaviruses (HPVs) related to abrogation of immunosurveillance exclusively against these viruses. The cutaneous viral carcinogenesis depends upon potentially oncogenic HPVs, the cocarcinogenic effect of ultraviolet irradiation, and genetic host factors, presumably a defect of anti-oncogenes or alleles of major histocompatibility complex and tumor necrosis factor locus involved in antigen presentation.
Majewski
S
S
Department of Dermatology, Warsaw School of Medicine, Poland.
Jablonska
S
S
D004819:Epidermodysplasia Verruciformis / Q000235:genetics* / Q000276:immunology / Q000382:microbiology*; D006801:Humans; D007157:Immunologic Surveillance; D027383:Papillomaviridae / Q000276:immunology / Q000472:pathogenicity*; D012878:Skin Neoplasms / Q000235:genetics / Q000276:immunology / Q000382:microbiology; D014412:Tumor Virus Infections / Q000235:genetics* / Q000276:immunology / Q000382:microbiology*