[Prevention of thromboembolism complications with low molecular weight heparin in microneurosurgical lumbar intervertebral disk operations].
In a prospective randomized study the effect of low-molecular-weight heparin (one injection of 1500 a PPT-Units/d Mono-Embolex NM) was compared with the effect of unfractionated heparin (5000 IU t.i.d.) in 200 patients undergoing micro-neurosurgical lumbar disc operations. Criteria of evaluation were lethal pulmonary embolisms, clinical signs of pulmonary embolisms, confirmed by radioisotopic lung scans, and major bleeding complications. The present investigation demonstrates, that a single daily subcutaneous injection of Mono-Embolex NM is an effective and well tolerated measure against thrombo-embolic complications, at least equal to the established low dose heparin prophylaxis with 5000 IU t.i.d.
Prestar
F J
FJ
Neurochirurgische Abteilung, Knappschaftskrankenhaus, Bergmannsheil, Gelsenkirchen-Buer.
D000328:Adult; D005260:Female; D006493:Heparin / Q000008:administration & dosage; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage*; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000601:surgery*; D008159:Lumbar Vertebrae / Q000601:surgery*; D008297:Male; D008866:Microsurgery; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D011292:Premedication; D011446:Prospective Studies; D011655:Pulmonary Embolism / Q000097:blood / Q000517:prevention & control*; D012307:Risk Factors; D013924:Thrombophlebitis / Q000097:blood / Q000517:prevention & control
D006495:Heparin, Low-Molecular-Weight; D006493:Heparin
Zur Prophylaxe thrombo-embolischer Komplikationen mit niedermolekularem Heparin bei mikroneurochirurgischen lumbalen Bandscheibenoperationen.