Studies on effect of pesticide Chlorfenwinfos on mouse immune system.
The effect of organophosphate pesticide--Chlorfenwinfos on the selected parameters of humoral and cellular immunologic response in mice was investigated. Hematologic and histologic examinations were run parallelly. The animals were treated with pesticide p.o. during 90 days in doses 1/100, 1/50 and 1/25 of LD50. It was found that Chlorfenwinfos exerts immunotropic effect. After high doses the strong suppressive effect in PFC and EA rosettes was observed. Significant involution of thymus was noted. Il-1 activity, DTH reaction (24 h after challenge) and endogenous and exogenous spleen colonies were stimulated. It seems that immunotropic effect of this pesticide is reversible. Three weeks after the exposure to this compound had been stopped, PFC, IgG and IgM level came back to the normal value.
Kowalczyk-Bronisz
S
S
Department of Immunopharmacology, Polish Academy of Sciences, Wrocław.
Giełdanowski
J
J
Bubak
B
B
Kotz
J
J
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D002709:Chlorfenvinphos / Q000633:toxicity*; D003114:Colony-Forming Units Assay; D005260:Female; D006087:Graft vs Host Reaction / Q000187:drug effects; D007107:Immune System / Q000187:drug effects*; D007111:Immunity, Cellular; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007375:Interleukin-1 / Q000378:metabolism; D007928:Lethal Dose 50; D007958:Leukocyte Count; D008221:Lymphoid Tissue / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D012397:Rosette Formation; D013154:Spleen / Q000637:transplantation; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007375:Interleukin-1; D002709:Chlorfenvinphos