title: Detection of occult nasopharyngeal primary tumours by means of in situ hybridization.
abstract: Detection of nasopharyngeal carcinoma primaries in patients presenting with neck node metastases may sometimes demand considerable efforts. By using the 'in situ hybridization' technique, we manage to identify the Epstein-Barr virus in neck metastases secondary to nasopharyngeal carcinomas. We propose that such identification in neck node metastases where the primary lesion is unknown indicates a nasopharyngeal primary.
authors.affiliation: Department of Otolaryngology, Mount Sinai Hospital, University of Toronto, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Feinmesser
authors.forename: M
authors.initials: M
authors.lastname: Feinmesser
authors.forename: J L
authors.initials: JL
authors.lastname: Freeman
authors.forename: A M
authors.initials: AM
authors.lastname: Noyek
authors.forename: N
authors.initials: N
authors.lastname: Livni
mesh_terms: D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006258:Head and Neck Neoplasms / Q000556:secondary*; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis*; D009382:Neoplasms, Unknown Primary / Q000175:diagnosis*; D009693:Nucleic Acid Hybridization
chemical_list: D004279:DNA, Viral