Human lung adrenergic and muscarinic cholinergic receptors in cancer and previous airways diseases.
In the present study adrenergic and muscarinic cholinergic receptors have been investigated in human lung parenchyma in cancer and previous airways diseases (chronic pneumonia, tuberculosis). It has been found that the number of muscarinic sites significantly increases in cancer and does not change both in chronic pneumonia and tuberculosis lung parenchyma in comparison with the normal tissue; the number of beta-adrenergic sites decreases in cancer, chronic pneumonia, as well as severe tuberculosis lung parenchyma. The important role of beta-adrenergic and muscarinic receptors in the formation of human lung adenocarcinoma is discussed.
Kondratenko
T Y
TY
Research Center of Molecular Diagnostics and Therapy, Moscow.
Kuzina
N V
NV
Zacharova
I V
IV
Kornilova
Z Ch
ZCh
Perelman
M I
MI
Severin
E S
ES
D000230:Adenocarcinoma / Q000378:metabolism; D000328:Adult; D002908:Chronic Disease; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008168:Lung / Q000378:metabolism*; D008175:Lung Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000378:metabolism; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D011976:Receptors, Muscarinic / Q000378:metabolism*; D014397:Tuberculosis, Pulmonary / Q000378:metabolism
D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D011976:Receptors, Muscarinic