title: Human papillomavirus types and cervical squamous intraepithelial lesions that recur after cold-knife conization.
abstract: The purpose of this study was to analyze the HPV types and histological margins of cervical squamous intraepithelial lesions (SILs) treated by cold-knife conization and to correlate this with recurrent disease. Of 203 cone biopsies done for SILs primarily because the entire lesion could not be visualized at colposcopy, follow-up information was available for 85 cases. Of these 85 cases, biopsy-proven recurrences were documented for 10 (12%) women. In the SILs which recurred after conization, the lesion was noted on the surgical margin in 7/10 (70%) cases. In contrast, SILs that did not recur after cold-knife conization were detected on the surgical margin in only 12% of cases. In 7 of the recurrences, the HPV type detected in the pretreatment SIL was the same as that detected in the SIL that occurred after conization. In the other 3 recurrences, one of either the primary or recurrent SILs was HPV positive and the other corresponding lesion HPV negative. It is concluded that detection of a SIL on the surgical margin is a marker for recurrent disease and that recurrences are often associated with the same HPV type as that noted in the pretreatment SIL.
authors.affiliation: Department of Pathology, SUNY, Stony Brook.
authors.forename: G
authors.initials: G
authors.lastname: Nuovo
authors.forename: J
authors.initials: J
authors.lastname: Moritz
authors.forename: A
authors.initials: A
authors.lastname: Kowalik
authors.forename: E
authors.initials: E
authors.lastname: Chalas
authors.forename: B
authors.initials: B
authors.lastname: Kaplan
authors.forename: W
authors.initials: W
authors.lastname: Mann
mesh_terms: D001706:Biopsy / Q000379:methods; D002278:Carcinoma in Situ / Q000382:microbiology* / Q000473:pathology / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000382:microbiology* / Q000473:pathology / Q000601:surgery; D003452:Cryosurgery / Q000379:methods*; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000382:microbiology*; D009693:Nucleic Acid Hybridization; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D002583:Uterine Cervical Neoplasms / Q000382:microbiology* / Q000473:pathology / Q000601:surgery
chemical_list: D004279:DNA, Viral