title: [Histiocyte activation syndrome associated with EBV in children].
abstract: VAHS (virus associated hemophagocytic syndrome) is a severe clinical and biological condition associated with certain menacing viral infections. It has been observed in patients with manifest immunodeficiency but also in previously apparently healthy children. Epstein-Barr virus (EBV) infection, although it is sometimes unrecognized and insidious, is one of the etiologies to be considered. Differential diagnosis with other causes of macrophage activation is a delicate task in pediatrics. Better understanding of the pathophysiology of the syndrome offers interesting therapeutic prospects.
authors.affiliation: Divisione di Malattie Infettive, Ospedale del Bambino Gesù di Roma.
authors.forename: M
authors.initials: M
authors.lastname: Caniglia
authors.forename: L
authors.initials: L
authors.lastname: Elia
mesh_terms: D002648:Child; D003937:Diagnosis, Differential; D006566:Herpesviridae Infections / Q000150:complications* / Q000175:diagnosis; D004854:Herpesvirus 4, Human; D015616:Histiocytosis, Non-Langerhans-Cell / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007244:Infectious Mononucleosis / Q000150:complications / Q000175:diagnosis
vernacular_title: La sindrome di attivazione istiocitaria legata all'EBV nel bambino.