The Lambert-Eaton syndrome.
This rare myasthenic disorder is the first neurologic disease found to be caused by antibodies against an ion channel complex. It presents an unusual opportunity to clarify the pathobiology of so-called receptor diseases, as well as to gain better understanding of the normal biology of acetylcholine release and its effect on neuromuscular junctions.
Smith
R G
RG
Department of Neurology, Baylor College of Medicine, Houston.
Appel
S H
SH
D015551:Autoimmunity; D015220:Calcium Channels / Q000502:physiology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D015624:Lambert-Eaton Myasthenic Syndrome / Q000276:immunology / Q000503:physiopathology* / Q000628:therapy
D015220:Calcium Channels; D007074:Immunoglobulin G