title: Regulation of peripheral-type benzodiazepine receptors following repeated benzodiazepine administration.
abstract: The effects of chronic benzodiazepine (BZD) treatment on rat peripheral-type benzodiazepine receptors (PBR) were studied. Five days treatment with the PBR ligands RO 5-4864 or diazepam (DZ) up-regulates kidney PBR. In contrast clonazepam, a specific central-type BZD receptor ligand, did not alter 3H-RO 5-4864 binding. Fourteen days administration of DZ produced an up-regulation of kidney and heart PBR and a down-regulation of testicular PBR. The results suggest that chronic BZD exposure differentially regulates PBR in peripheral organs.
authors.affiliation: Institute of Cellular Biology, Faculty of Medicine, University of Buenos Aires, Argentina.
authors.forename: D J
authors.initials: DJ
authors.lastname: Calvo
authors.forename: J H
authors.initials: JH
authors.lastname: Medina
mesh_terms: D000818:Animals; D001569:Benzodiazepines / Q000494:pharmacology*; D001570:Benzodiazepinones / Q000493:pharmacokinetics* / Q000494:pharmacology; D002998:Clonazepam / Q000494:pharmacology; D003292:Convulsants; D003975:Diazepam / Q000494:pharmacology; D004334:Drug Administration Schedule; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000502:physiology; D014018:Tissue Distribution
chemical_list: D001570:Benzodiazepinones; D003292:Convulsants; D011963:Receptors, GABA-A; D001569:Benzodiazepines; C028513:4'-chlorodiazepam; D002998:Clonazepam; D003975:Diazepam