title: Tumour suppressor genes.
abstract: Genes responsible for the hereditary predisposition to a variety of human cancers have now been isolated. Their function seems to be part of complex signalling pathways involved in the control of cellular differentiation and the cell cycle. The presence of a single copy of these genes appears to be sufficient to ensure normal development, i.e. prevents tumorigenesis, and has earned them the name--tumour suppressor genes.
authors.affiliation: ICRF Oncology Group, Institute of Child Health, London, U.K.
authors.forename: J K
authors.initials: JK
authors.lastname: Cowell
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000235:genetics; D005134:Eye Neoplasms / Q000235:genetics; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D017253:Neurofibromatoses / Q000235:genetics; D012175:Retinoblastoma / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000235:genetics; D009396:Wilms Tumor / Q000235:genetics
chemical_list: D016159:Tumor Suppressor Protein p53