title: L-cysteine augments the vasorelaxation induced by sodium nitrite and SIN-1 but not that due to acetylcholine.
abstract: The effects of 1 mM L-cysteine on sodium nitrite-, 3-morpholinosydnonimine (SIN-1)- and acetylcholine-induced relaxation and cyclic GMP accumulation were studied in isolated noradrenaline-precontracted rat mesenteric arterial rings. L-Cysteine augmented the relaxation and cyclic GMP increase induced by sodium nitrate and SIN-1 but not those induced by acetylcholine. The effects of L-cysteine on relaxation were independent of the presence of intact endothelium. The results suggest that L-cysteine protects exogenously released nitric oxide.
authors.affiliation: Department of Biomedical Sciences, University of Tampere, Finland.
authors.forename: P
authors.initials: P
authors.lastname: Arvola
authors.forename: I
authors.initials: I
authors.lastname: Pörsti
authors.forename: P
authors.initials: P
authors.lastname: Vuorinen
authors.forename: H
authors.initials: H
authors.lastname: Huhtala
authors.forename: T
authors.initials: T
authors.lastname: Metsä-Ketelä
authors.forename: H
authors.initials: H
authors.lastname: Vapaatalo
mesh_terms: D000109:Acetylcholine / Q000008:administration & dosage; D000818:Animals; D006152:Cyclic GMP / Q000378:metabolism; D003545:Cysteine / Q000008:administration & dosage / Q000494:pharmacology*; D004357:Drug Synergism; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects / Q000502:physiology; D008981:Molsidomine / Q000008:administration & dosage / Q000031:analogs & derivatives; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012977:Sodium Nitrite / Q000008:administration & dosage; D014664:Vasodilation / Q000187:drug effects* / Q000502:physiology
chemical_list: D009569:Nitric Oxide; C002385:linsidomine; D008981:Molsidomine; D006152:Cyclic GMP; D003545:Cysteine; D012977:Sodium Nitrite; D000109:Acetylcholine