title: Cystectomy and substitution enterocystoplasty: alternative primary treatment for T2/3 bladder cancer.
abstract: The optimal treatment for invasive bladder cancer remains controversial. Although external beam radiotherapy is able to eradicate the disease in a number of patients, the difficulty is selecting those who will respond. Those who do develop a local recurrence will require a salvage cystectomy combined with urinary diversion. The results of performing cystectomy and bladder reconstruction as a primary procedure are presented and the concept of combining this with chemotherapy as an alternative strategy for the management of bladder cancer is discussed.
authors.affiliation: Department of Urology, St Bartholomew's Hospital, London.
authors.forename: S A
authors.initials: SA
authors.lastname: Holmes
authors.forename: T J
authors.initials: TJ
authors.lastname: Christmas
authors.forename: R S
authors.initials: RS
authors.lastname: Kirby
authors.forename: W F
authors.initials: WF
authors.lastname: Hendry
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery*; D000328:Adult; D018288:Carcinoma, Small Cell / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000601:surgery*; D002295:Carcinoma, Transitional Cell / Q000601:surgery*; D015653:Cystectomy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology; D001744:Urinary Bladder Calculi / Q000209:etiology; D001749:Urinary Bladder Neoplasms / Q000601:surgery*; D014549:Urinary Incontinence / Q000601:surgery; D014552:Urinary Tract Infections / Q000209:etiology; D014563:Urodynamics