title: Lacidipine: a dihydropyridine calcium antagonist with antioxidant activity.
abstract: Lacidipine, a new, long-acting antihypertensive dihydropyridine calcium antagonist was tested for potential antioxidant effect in a series of tests that consider specific radical species. A direct quenching of several radical species could be measured. Moreover, in biological membranes deriving from rat brain tissue, lacidipine showed an activity comparable to reference antioxidant compounds like vitamin E.
authors.affiliation: Glaxo Research Laboratories, Verona, Italy.
authors.forename: F T
authors.initials: FT
authors.lastname: van Amsterdam
authors.forename: A
authors.initials: A
authors.lastname: Roveri
authors.forename: M
authors.initials: M
authors.lastname: Maiorino
authors.forename: E
authors.initials: E
authors.lastname: Ratti
authors.forename: F
authors.initials: F
authors.lastname: Ursini
mesh_terms: D000818:Animals; D000975:Antioxidants; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D004095:Dihydropyridines / Q000494:pharmacology*; D004347:Drug Interactions; D005609:Free Radicals; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D016877:Oxidants; D051381:Rats; D011919:Rats, Inbred Strains; D013481:Superoxides / Q000737:chemistry
chemical_list: D000975:Antioxidants; D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D005609:Free Radicals; D016877:Oxidants; D013481:Superoxides; C060285:lacidipine