title: Pernicious anaemia in Africans.
abstract: Ten cases of pernicious anaemia seen over a 15-year period (1973-1988) in a Lagos hospital are presented. Their ages ranged from 34 to 67 with a mean of 53.6 years. Females outnumbered males 6 to 4. Complications seen include gastric carcinoma, myelopathy, peripheral neuropathy, skin hyperpigmentation, hair depigmentation and diarrhoea. Reluctance to consider the diagnosis owing to firmly held notions of its rarity and a penchant for empirically treating chronic anaemias with all available haematinics and blood transfusion are probably contributory to its underdiagnosis. The fact that seven of the patients presented were seen in the last three years and three of them in the last one year raises the possibility of an increasing incidence of pernicious anaemia in Africans. The disease may be much less rare in Africans than once believed, and medical education should emphasize its existence and advocate greater care in the management of chronic anaemias.
authors.affiliation: Department of Medicine, Lagos University Teaching Hospital, Nigeria.
authors.forename: O O
authors.initials: OO
authors.lastname: Akinyanju
authors.forename: C C
authors.initials: CC
authors.lastname: Okany
mesh_terms: D000126:Achlorhydria / Q000209:etiology; D000328:Adult; D000368:Aged; D000752:Anemia, Pernicious / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D001323:Autoantibodies / Q000276:immunology; D001327:Autoimmune Diseases / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D001853:Bone Marrow / Q000473:pathology; D003937:Diagnosis, Differential; D005221:Fatigue / Q000209:etiology; D005260:Female; D006801:Humans; D006879:Hydroxocobalamin / Q000627:therapeutic use; D015994:Incidence; D007437:Intrinsic Factor / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D010523:Peripheral Nervous System Diseases / Q000209:etiology; D010859:Pigmentation Disorders / Q000209:etiology; D011602:Psychophysiologic Disorders / Q000175:diagnosis; D012189:Retrospective Studies; D014805:Vitamin B 12 / Q000097:blood / Q000627:therapeutic use; D014806:Vitamin B 12 Deficiency / Q000150:complications* / Q000188:drug therapy
chemical_list: D001323:Autoantibodies; D007437:Intrinsic Factor; D014805:Vitamin B 12; D006879:Hydroxocobalamin