Cellular signalling events stimulated by myeloid haemopoietic growth factors.
In haemopoietic cells, proliferation, commitment to development, lineage restriction and survival via suppression of apoptosis can all be controlled by haemopoietic growth factors. The mechanisms underlying the regulation of these events can now be studied since recombinant forms of most of these haemopoietic growth factors are now available. Recent advances in cell purification techniques and the development of multipotent cell lines (see Spangrude et al, 1988; Whetton, 1990; Heyworth et al, 1988, 1990a; Jones et al, 1990) have provided suitable cell populations on which to study the cellular signalling events associated with differentiation and lineage restriction. This process has started with the elucidation of the structure and expression of many of the myeloid growth factor receptors, which should now facilitate progress in the study of the signal transduction mechanisms these growth factors employ. Another important facet of these studies will be to determine whether a single growth factor with multiple target cell types, ranging from multipotent cells to postmitotic cells (e.g. neutrophils), employs distinct signalling mechanisms depending on the target cell in question. The cellular signalling events elicited by each of these growth factors and the ways in which they can regulate the transcriptional activation of genes associated with specific developmental events are going to be key areas of haemopoietic research in the next few years.
Kan
O
O
Evans
C A
CA
Whetton
A D
AD
D000328:Adult; D000595:Amino Acid Sequence; D000818:Animals; D000242:Cyclic AMP / Q000502:physiology; D006410:Hematopoiesis / Q000502:physiology*; D016298:Hematopoietic Cell Growth Factors / Q000502:physiology*; D006801:Humans; D008024:Ligands; D008969:Molecular Sequence Data; D010716:Phosphatidylinositols / Q000502:physiology; D011494:Protein Kinases / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D015398:Signal Transduction
D016298:Hematopoietic Cell Growth Factors; D008024:Ligands; D010716:Phosphatidylinositols; D011518:Proto-Oncogene Proteins; D011956:Receptors, Cell Surface; D000242:Cyclic AMP; D011494:Protein Kinases