[Infections after bone marrow transplantation in childhood].
In 66 children having undergone bone marrow transplantation (BMT) the occurrence of infections was studied retrospectively. Bacterial infections were mostly found in the early period after transplantation before marrow engraftment. The analysis of positive blood cultures showed a dominance of gram-positive bacteria, especially of coagulase-negative staphylococci. Cytomegalovirus (CMV) infections were most important, because of its high rate and the risk of CMV associated interstitial pneumonia (IP), two patients suffered from. Infections from herpes simplex virus (HSV), varizella zoster virus (VZV) and Epstein Barr virus (EBV) had no influence on prognosis. In fungal infections the systemic aspergillosis was the most important complication. To increase the effectiveness and safety of therapy the serum levels of antibiotics and antifungal drugs should be determined.
Ludwig
S
S
Universitäts-Kinderklinik Jussuf Ibrahim, Jena.
Ludwig
U
U
Färber
I
I
Wutzler
P
P
Straube
E
E
Koch
H
H
Hermann
J
J
Fuchs
D
D
Zintl
F
F
D000293:Adolescent; D001228:Aspergillosis / Q000209:etiology*; D016470:Bacteremia / Q000209:etiology; D016026:Bone Marrow Transplantation; D002177:Candidiasis / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006566:Herpesviridae Infections / Q000209:etiology*; D006801:Humans; D007223:Infant; D008297:Male; D009894:Opportunistic Infections / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors
Infektionen nach Knochenmarktransplantationen im Kindesalter.