[Increase of calcium-dependent activity of phospholipase C in the myocardium in adaptation of animals to short-term stress effects].
The effect of adaptation of rats to repeated short-term stress exposures was studied on the density and the affinity of alpha 1-adrenoceptors in the heart and on the phospholipase C activity and sensitivity to changes in Ca2+ concentration. It was found that adaptation to stress was accompanied by a desensitization of alpha 1-adrenoceptors and also by an increase in Ca(2+)-dependence of phospholipase C activity in the heart. The role of increased activity of phospholipase C and activated inositol triphosphate-diacylglycerol regulatory cascade is discussed as regard to the previously revealed accumulation of heat shock proteins in the myocardium and to the adaptive protection of the heart.
Meerson
F Z
FZ
Kopylov
Iu N
IuN
Avdonin
P V
PV
D000222:Adaptation, Physiological; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002462:Cell Membrane / Q000201:enzymology; D007103:Immobilization; D009206:Myocardium / Q000201:enzymology* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000032:analysis; D013312:Stress, Physiological / Q000378:metabolism*; D013997:Time Factors; D010738:Type C Phospholipases / Q000378:metabolism*
D011942:Receptors, Adrenergic, alpha; D010738:Type C Phospholipases; D002118:Calcium
Povyshenie kal'tsiĭ-zavisimoĭ aktivnosti fosfolipazy C v miokarde pri adaptatsii zhivotnykh k kratkovremennym stressornym vozdeĭstviiam.