title: [Analysis of steroids. Part 44: Analytical investigation of the intermediates of the synthesis of pipecuronium bromide (Arduan)].
abstract: The following methods are described for the analytical investigation of the intermediates of the synthesis of pipecuronium bromide (Arduan) (for the numbering of the intermediates and their impurities see Figure 1.). 1. Gas chromatographic methods (capillary GC using fused silica capillaries Ultra-2 and Silar 10C WCOT) for the impurity profiling of intermediates I, II, IV and V including the identification and spectroscopic characterization of their impurities; 2. TLC methods for the similar characterisation of the further intermediates (III, VI, VII and VIII); 3. Gas chromatographic assay methods for IV and V using fused silica capillary technique and internal standards; 4. Potentiometric titration methods for the determination of VII and VIII using 0.1 M hydrochloric acid as the titrant.
authors.affiliation: Richter Gedeon Vegyészeti Gyár Rt., Budapest.
authors.forename: A
authors.initials: A
authors.lastname: Laukó
authors.forename: P
authors.initials: P
authors.lastname: Horváth
authors.forename: F
authors.initials: F
authors.lastname: Trischler
authors.forename: S
authors.initials: S
authors.lastname: Görög
mesh_terms: D015113:Androstane-3,17-diol / Q000031:analogs & derivatives* / Q000032:analysis / Q000138:chemical synthesis / Q000737:chemistry; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D009466:Neuromuscular Blocking Agents / Q000032:analysis / Q000138:chemical synthesis / Q000737:chemistry*; D017300:Pipecuronium; D010879:Piperazines / Q000032:analysis / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D009466:Neuromuscular Blocking Agents; D010879:Piperazines; D017300:Pipecuronium; D015113:Androstane-3,17-diol
vernacular_title: Adatok a szteránvázas vegyületek analitikájához 44. Pipecuronium bromid (Arduan) szintézis intermedierjeinek analitikája.