title: Treatment of visceral leishmaniasis (kala-azar) with aminosidine (= paromomycin)-antimonial combinations, a pilot study in Bihar, India.
abstract: A 20 d drug regimen of aminosidine (= paromomycin) at 12 mg/kg/d in combination with sodium stibogluconate at 20 mg/kg/d proved efficacious and well-tolerated in patients with visceral leishmaniasis in the State of Bihar, India. Eighteen of 22 evaluable patients achieved an ultimate cure. The remaining 4 patients, although not cleared of parasites, had their parasite grade reduced and also improved clinically. This confirms prior findings in Kenyan patients with kala-azar, and indicates that this regimen is a valid alternative to antimonial compounds alone in the State of Bihar, where cases of kala-azar not responding to antimonial drugs and intolerant of pentamidine are increasingly recorded.
authors.affiliation: Patna Medical College, Tripolia Social Service Hospital, India.
authors.forename: C P
authors.initials: CP
authors.lastname: Thakur
authors.forename: P
authors.initials: P
authors.lastname: Olliaro
authors.forename: S
authors.initials: S
authors.lastname: Gothoskar
authors.forename: S
authors.initials: S
authors.lastname: Bhowmick
authors.forename: B K
authors.initials: BK
authors.lastname: Choudhury
authors.forename: S
authors.initials: S
authors.lastname: Prasad
authors.forename: M
authors.initials: M
authors.lastname: Kumar
authors.forename: B B
authors.initials: BB
authors.lastname: Verma
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000967:Antimony Sodium Gluconate / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007223:Infant; D007898:Leishmaniasis, Visceral / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010303:Paromomycin / Q000627:therapeutic use*; D010865:Pilot Projects
chemical_list: D010303:Paromomycin; D000967:Antimony Sodium Gluconate