[The intracellular second messenger system and its regulatory effects in children with a bronchial asthma attack complicated by heart failure].
Components of the intracellular mediators system: calmodulin in leukocytes, Ca2+ and cyclic nucleotides in leukocytes and blood plasma were studied in children with attack of bronchial asthma and heart failure. Alterations in content of these biologically active substances correlated with clinical manifestations of bronchial asthma: severity of the disease, duration of the attack, contractile activity of myocardium. Calmodulin, Ca2+ and cyclic nucleotides were demonstrated to be involved in development of the asthmatic attack. Alterations in the system calmodulin-Ca2+ were related to adaptation and contributed to realization of regulating effects responsible for a decrease of impairments in tissues.
Bakanov
M I
MI
Bershova
T V
TV
Balabolkin
I I
II
Gerasimov
A A
AA
Mikhaĭlova
I L
IL
D000293:Adolescent; D001249:Asthma / Q000150:complications / Q000378:metabolism*; D002118:Calcium / Q000097:blood; D002147:Calmodulin / Q000097:blood; D002413:Cations, Divalent; D002648:Child; D002675:Child, Preschool; D000242:Cyclic AMP / Q000097:blood; D006152:Cyclic GMP / Q000097:blood; D006331:Heart Diseases / Q000150:complications*; D006801:Humans; D007962:Leukocytes / Q000737:chemistry; D015290:Second Messenger Systems
D002147:Calmodulin; D002413:Cations, Divalent; D000242:Cyclic AMP; D006152:Cyclic GMP; D002118:Calcium
Sistema vtorichnykh vnutrikletochnykh posrednikov i ee reguliarognye éffekty u deteĭ v pristupnom periode bronkhial'noĭ astmy, oslozhnennoĭ serdechnoĭ nedostatochnost'iu.