Brain, lung, and cardiovascular interactions with cocaine and cocaine-induced catecholamine effects.
The pathophysiologic effects of cocaine on neuronal, pulmonary, and cardiovascular tissue are related to the drug's interaction with select catecholamine and neuroendocrine systems. Cocaine has been shown to alter circulating levels of the neurotransmitters, dopamine, norepinephrine, epinephrine, as well as the hypothalamic-pituitary-adrenal axis hormones corticotropin-releasing factor (CRF), adrenocorticotropic hormone (ACTH), and cortisol. Furthermore, brain and lung tissue have been identified as primary sites of cocaine sequestration and metabolism. This paper reviews evidence suggesting that steroid-potentiated actions of catecholamines on vascular tissues contributes to the etiology of cocaine-related medical complications, including ischemic stroke, coronary ischemia, and ischemia-based renal failure.
Wilkins
J N
JN
Substance Abuse Programs, West Los Angeles, VAMC, CA 90073.
D000305:Adrenal Cortex Hormones / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics; D000324:Adrenocorticotropic Hormone / Q000032:analysis; D001812:Blood-Brain Barrier; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D002395:Catecholamines / Q000493:pharmacokinetics*; D003042:Cocaine / Q000009:adverse effects* / Q000378:metabolism; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D008168:Lung / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D019966:Substance-Related Disorders / Q000503:physiopathology*
D000305:Adrenal Cortex Hormones; D002395:Catecholamines; D000324:Adrenocorticotropic Hormone; D003042:Cocaine