[Experimental studies of the inhibition of fibrogenesis].
Colchicine as well HOE 077 were found to be effective in the inhibition of hepatic collagen accumulation after bile duct ligation in rats. The effect was additive and was truly reflected by changes in the serum PIIIP and 7s-collagen (IV) concentration. Extrahepatic effects on collagen synthesis were not detected when HOE 077 was used. Thus further studies on the potential clinical usefulness of these compounds are clearly indicated.
Böker
K
K
Abteilung Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover, Frankfurt/M.
Schwarting
G
G
Kaule
G
G
Günzler
V
V
Ohlendorf
S
S
Schmidt
E
E
D000818:Animals; D003078:Colchicine / Q000494:pharmacology; D003094:Collagen / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D008099:Liver / Q000473:pathology; D008106:Liver Cirrhosis, Experimental / Q000473:pathology*; D008297:Male; D011393:Procollagen-Proline Dioxygenase / Q000037:antagonists & inhibitors*; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D011725:Pyridines; C074630:lufironil; D003094:Collagen; D011393:Procollagen-Proline Dioxygenase; D003078:Colchicine
Experimentelle Untersuchungen zur Hemmung der Fibrogenese.