title: Solid-state 31P NMR spectroscopy of bone and bone substitutes.
abstract: Using magic angle sample spinning 31P NMR spectroscopy, we studied NMR parameters of hydroxyapatite, calcium-deficient hydroxyapatite, and beta-tricalcium phosphate. These data were compared to rabbit bone parameters. Rabbit bone spectrum is similar to deficient hydroxyapatite spectrum but high-power proton decoupling did not modify its linewidth. Moreover, both bone T1 and deficient hydroxyapatite T1 were much longer than pure hydroxyapatite T1 and beta-tricalcium phosphate T1. We used these results to develop quantitative analysis of newly deposited bone inside beta-tricalcium phosphate implants in rabbit. This method made it possible to demonstrate the effect of porosity on osteoinduction of biomaterials.
authors.affiliation: Laboratoire de Biophysique, Faculté de Médecine, Lille II, France.
authors.forename: X
authors.initials: X
authors.lastname: Marchandise
authors.forename: P
authors.initials: P
authors.lastname: Belgrand
authors.forename: A P
authors.initials: AP
authors.lastname: Legrand
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000032:analysis*; D001842:Bone and Bones / Q000378:metabolism*; D002130:Calcium Phosphates / Q000032:analysis; D017886:Durapatite; D006882:Hydroxyapatites / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy; D016348:Osseointegration / Q000502:physiology*; D011817:Rabbits
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; D006882:Hydroxyapatites; C485817:beta-tricalcium phosphate; D017886:Durapatite; C018392:tricalcium phosphate