Incidence of hepatitis D virus infection in Japanese patients with hepatocellular carcinoma--immunohistochemical investigation of the delta antigen.
In order to clarify the incidence of the delta agent among hepatocellular carcinomas (HCCs) in Kurume, where the hepatitis B infection and its related HCC are most prevalent in Japan, liver tissues from sero hepatitis B surface antigen-positive autopsy cases, with or without HCC, were immunohistochemically investigated for detection of the delta antigen. Only one patient (1.7%) among 58 patients with HCC was found to have delta-antigen in the nuclei in the hepatocytes, which were diffusely distributed throughout the non-cancerous liver. None of 26 patients with liver cirrhosis showed delta-antigen in the liver tissue. The incidence is so low that the delta agent is unlikely to have a role in the development of HCC in our areas.
Kage
M
M
Department of Pathology, Kurume University School of Medicine, Japan.
Kosai
K
K
Shimamatsu
K
K
Nakashima
O
O
Haramaki
M
M
Yasunaga
M
M
Iha
H
H
Kojiro
M
M
Govindarajan
S
S
D000956:Antigens, Viral / Q000032:analysis*; D006528:Carcinoma, Hepatocellular / Q000150:complications*; D005260:Female; D003699:Hepatitis D / Q000150:complications / Q000453:epidemiology* / Q000276:immunology; D003698:Hepatitis Delta Virus / Q000276:immunology* / Q000302:isolation & purification; D035923:Hepatitis delta Antigens; D006801:Humans; D007124:Immunoenzyme Techniques; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008113:Liver Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies
D000956:Antigens, Viral; D035923:Hepatitis delta Antigens; C442244:hepatitis delta virus large antigen