[Ganglioside protection of the erythrocyte membranes in myocardial ischemia].
Myocardial ischemia was shown to lead to modification of structural and functional organization of rat erythrocyte membranes. Thus, it was found that the activity of Na+, K+-ATP-ase markedly decreased, while accumulation of LPO products and of lysophosphatidylcholine (lyso--PC) took place in erythrocyte membranes of rats subjected to myocardial ischemia. Using nonpenetrating modifier trinitrobenzosulfonic acid, an increase in the content of modified phosphatidylethanolamine in erythrocyte membranes of ischemic rats was revealed as compared to the membranes of control animals. The intravenous administration of gangliosides (30 mg/kg) resulted in partial normalization of Na+, K+(-)ATPase activity, of LPO product and lysoPC content and of transbilayer distribution of lipids.
Tiurin
V A
VA
Bagrov
A Ia
AIa
Fedorova
O V
OV
Zhabko
E P
EP
Tiurina
Iu Iu
IuIu
Avrova
N F
NF
Das
D K
DK
Kagan
V E
VE
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D005732:Gangliosides / Q000008:administration & dosage*; D015227:Lipid Peroxidation / Q000187:drug effects; D017202:Myocardial Ischemia / Q000097:blood / Q000188:drug therapy*; D010743:Phospholipids / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood / Q000187:drug effects
D005732:Gangliosides; D010743:Phospholipids; D000254:Sodium-Potassium-Exchanging ATPase
Zashchita gangliozidami membran éritrotsitov pri ishemii miokarda.