title: Three-dimensional structure for the beta 2 adrenergic receptor protein based on computer modeling studies.
abstract: Computer-aided model building techniques have been used to construct three-dimensional model structures for hamster beta 2 adrenergic receptor. Experimental data were used as constraints to guide the model building procedure, and a number of rather strict criteria were applied to assess the physical plausibility of model structures. We present details of our best model structure to date, which is consistent with a large body of experimental data. We also discuss in detail our model building procedures and evaluation criteria, which we believe may be of general utility in modeling projects.
authors.affiliation: Molecular Bioengineering Program, University of Washington, Seattle 98195.
authors.forename: K
authors.initials: K
authors.lastname: MaloneyHuss
authors.forename: T P
authors.initials: TP
authors.lastname: Lybrand
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D003196:Computer Graphics; D003198:Computer Simulation; D006224:Cricetinae; D004837:Epinephrine / Q000737:chemistry; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011943:Receptors, Adrenergic, beta / Q000737:chemistry / Q000648:ultrastructure*; D012995:Solubility; D013329:Structure-Activity Relationship; D014867:Water
chemical_list: D011943:Receptors, Adrenergic, beta; D014867:Water; D004837:Epinephrine