title: Localized magnetic resonance spectroscopy measurement of brain lactate during intravenous lactate infusion in healthy volunteers.
abstract: Proton magnetic resonance spectroscopy (1H MRS) localized to the left temporal-parietal region in 8 healthy volunteers detected a 2.1-fold +/- 0.7-fold increase (all values +/-SD) in brain lactate during intravenous infusion of 0.5 molar (M) sodium lactate (5 meq/kg over 20 minutes). Significant increases in brain lactate occurred within 5-10 minutes after starting lactate infusion, progressively rose during the infusion, then decreased towards baseline levels during 30 minutes post-infusion. Venous lactate concentration increased from 0.8 +/- 0.2 mM to 10.9 +/- 4.1 mM or 13.6-fold during the infusion. Flow phantom findings in vitro suggest attenuation of 1H MRS blood lactate signal from arteries and veins as a result of flow velocity effects. Correlations between paired blood and brain lactate measurements at each sampling time indicate a non-linear relationship between compartments during lactate infusion.
authors.affiliation: Department of Psychiatry, University of Washington, School of Medicine, Harborview Medical Center, Seattle 98104.
authors.forename: S R
authors.initials: SR
authors.lastname: Dager
authors.forename: K I
authors.initials: KI
authors.lastname: Marro
authors.forename: T L
authors.initials: TL
authors.lastname: Richards
authors.forename: G D
authors.initials: GD
authors.lastname: Metzger
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D001921:Brain / Q000378:metabolism*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007773:Lactates / Q000378:metabolism* / Q000493:pharmacokinetics; D019344:Lactic Acid; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011522:Protons
chemical_list: D007773:Lactates; D011522:Protons; D019344:Lactic Acid