Autoradiographic evidence of opioid binding sites in rat growth plate chondrocytes.
After 125I-beta-endorphin was intravenously injected in rats, an autoradiographic study of distal femur growth plates was performed. Results show a specific binding of the radiolabelled peptide to chondrocytes suggesting the possible existence of an opiate modulation of growth plate physiology.
Freire-Garabal
M
M
Department of Pharmacology, Faculty of Medicine, University of Santiago de Compostela, Spain.
Castaño
M T
MT
Belmonte
A
A
Jorge
J
J
Couceiro
J
J
Núñez
M J
MJ
D000818:Animals; D001345:Autoradiography; D006132:Growth Plate / Q000187:drug effects / Q000378:metabolism*; D007457:Iodine Radioisotopes; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000378:metabolism*; D001615:beta-Endorphin / Q000378:metabolism
D007457:Iodine Radioisotopes; D011957:Receptors, Opioid; D009270:Naloxone; D001615:beta-Endorphin; D009020:Morphine