[Alcoholic mitochondrial cardiomyopathy].
The effect of alcohol on oxidative phosphorylation, activity of cytochrome oxidase and the content of cytochromes in mitochondria of the heart muscle was studied in rabbits after 14- and 21-day subcutaneous administration of 20% alcohol solution. Alcohol was found to exert an inhibitory effect on oxygen consumption and on the rate of energy production in mitochondria of the heart muscle, to decrease the specific activity of cytochrome oxidase and to increase the cytochrome content in the mitochondria. The authors classify these metabolic derangements under the concept of alcoholic mitochondrial cardiomyopathy and discuss broader aspects of mitochondrial diseases in medicine.
Gvozdjáková
A
A
Farmakologické laboratórium LFUK, Bratislave, CSFR.
Kucharská
J
J
Miklovicová
E
E
Bozek
P
P
Gvozdják
J
J
D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced; D003580:Cytochromes / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism; D000431:Ethanol / Q000633:toxicity*; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D011817:Rabbits
D003580:Cytochromes; D000431:Ethanol; D003576:Electron Transport Complex IV
Alkoholová mitochondriálna kardiomyopatia.