[Immunohistochemical analysis of CA19-9, SLX, and CA125 in adenoid cystic carcinoma of trachea and bronchus].
We examined the usefulness of 3 carbohydrate antigens, CA19-9, CA125, and SLX, as tumor markers in adenoid cystic carcinoma of the trachea and bronchus, immunohistochemically and clinically. CA19-9 and SLX were detected immunohistochemically in normal tracheal and bronchial glands, but CA125 was not detected. Bronchial secretions obtained from 7 patients without cancer contained high levels of these 3 carbohydrate antigens. There was positive immunohistochemical staining for CA19-9, CA125, and SLX in 5 of 9, 1 of 9, and 3 of 8 patients with tracheal or bronchial adenoid cystic carcinoma, respectively. In a case of bronchial adenoid cystic carcinoma in whom pretreatment serum CA19-9 showed a very high level, this marker changed in parallel with the clinical course. These results suggest the possibility that CA19-9 and SLX could be used as useful markers in patients with tracheal and bronchial adenoid cystic carcinoma.
Tamura
S
S
Third Department of Internal Medicine, Hyogo College of Medicine, Japan.
Yamaguchi
K
K
Terada
M
M
Nakano
T
T
Maeda
J
J
Iwahashi
N
N
Hada
T
T
Higashino
K
K
D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis*; D001984:Bronchial Neoplasms / Q000175:diagnosis*; D003528:Carcinoma, Adenoid Cystic / Q000175:diagnosis*; D006801:Humans; D007150:Immunohistochemistry; D013899:Thoracic Neoplasms / Q000175:diagnosis*
D015295:Antigens, Tumor-Associated, Carbohydrate