[3H-tert-butylbicyclo-ortho-benzoate--a new ligand for chloride ion channel of GABA-A receptor].
The study was made of the binding of 35S-t-butylbicyclophosphorothionate and 3H-t-butylbicycloorthobenzoate (TBOB) which label a GABAA receptor-regulated chloride ionophores to glass fiber filters GF/B and GF/C. The rate of 3H-TBOB binding was higher. GABA displayed a biphasic effect on 3H-TBOB binding to rat brain synaptic membrane; enhancement at low concentrations of the agent and inhibition at higher ones. The results suggest that GABA may modulate the 3H-TBOB binding.
Golovko
A I
AI
Sofronov
G A
GA
D000818:Animals; D001921:Brain / Q000378:metabolism; D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D002712:Chlorides / Q000378:metabolism*; D003292:Convulsants; D066298:In Vitro Techniques; D008024:Ligands; D008297:Male; D011869:Radioligand Assay; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism*; D013570:Synaptic Membranes / Q000378:metabolism; D014316:Tritium
D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D002712:Chlorides; D003292:Convulsants; D008024:Ligands; D011963:Receptors, GABA-A; D014316:Tritium; C037476:tert-butylbicyclophosphorothionate; C046308:tert-butylbicyclo-2-benzoate
3H-tretbutilbitsikloortobenzoat--novyĭ ligand dlia khlor-ionnogo kanala GAMK-A-retseptora.