title: [The effect of cyclic nucleotides on the sensitivity of early mouse embryos to biogenic monoamine antagonists].
abstract: The effect of lipophilic cAMP analogs on the sensitivity of preimplantation mouse embryos of two strains to cytotoxic serotonin and adrenalin antagonists was studied. Dioctanoyl-cAMP significantly decreased the sensitivity of embryos to inmecarb and cyproheptadine: experimental embryos developed to the stage of morula or blastocyst, in contrast to control embryos incubated without this protector. A somewhat weaker effect was observed in experiments with propranolol: embryos incubated in the propranolol-containing medium after the addition of dioctanoyl-cAMP were capable of one to two cleavage divisions. 8-bromomonobutyryl-cAMP partially suppressed the inhibitory effect of cyproheptadine and did not affect the sensitivity of embryos to propranolol. These data suggest cAMP involvement in the regulatory activity of neurotransmitters in the early mouse embryos.
authors.forename: K A
authors.initials: KA
authors.lastname: Sadykova
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Sakharova
authors.forename: L N
authors.initials: LN
authors.lastname: Markova
mesh_terms: D000818:Animals; D015306:Biogenic Monoamines / Q000037:antagonists & inhibitors*; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004622:Embryo, Mammalian / Q000187:drug effects*; D047108:Embryonic Development / Q000187:drug effects; D004837:Epinephrine / Q000037:antagonists & inhibitors; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008813:Mice, Inbred ICR; D011247:Pregnancy; D012702:Serotonin Antagonists / Q000494:pharmacology
chemical_list: D015306:Biogenic Monoamines; D012702:Serotonin Antagonists; D005576:Colforsin; D000242:Cyclic AMP; D004837:Epinephrine
vernacular_title: Vliianie tsiklicheskikh nukleotidov na chuvstvitel'nost' rannikh zarodysheĭ mysheĭ k antagonistam biogennykh monoaminov.