title: Axons from the olfactory bulb transplanted into the cerebellum form synapses with dendrites in the granular layer, as demonstrated by mouse allelic form of Thy-1 and electron microscopy.
abstract: Transplant-to-host axon projection and synapse formation from the olfactory bulb (OB) transplant to the host cerebellum were studied using the mouse allelic form of Thy-1 (AKR strain of Thy-1.1 was used as host and BALB/c strain of Thy-1.2 as graft). Thy-1.2 immunohistochemical and ultrastructural examination showed that numerous OB axons elongate into the cerebellar granular layer and form asymmetrical synapses there with dendrites of host origin (perhaps of the host granule neuron). Factors which support this mismatched synapse formation are discussed.
authors.affiliation: Department of Anatomy, Hamamatsu University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Fujii
authors.forename: T
authors.initials: T
authors.lastname: Hayakashi
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D016380:Brain Tissue Transplantation / Q000502:physiology*; D002462:Cell Membrane / Q000648:ultrastructure; D002531:Cerebellum / Q000166:cytology / Q000502:physiology*; D003712:Dendrites / Q000502:physiology*; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008818:Mice, Neurologic Mutants; D008854:Microscopy, Electron; D009411:Nerve Endings / Q000648:ultrastructure; D009830:Olfactory Bulb / Q000166:cytology* / Q000637:transplantation; D013569:Synapses / Q000502:physiology*; D014184:Transplantation, Homologous