Ki-1 large cell lymphoma with regressing lesions in a child.
An 8-year-old boy was seen with a cutaneous Ki-1 anaplastic, large cell lymphoma with multiple lesions. Some of the lesions showed spontaneous regression. During more than seven years of disease no systemic involvement was observed, but recurrent, self-healing lesions did appear. Histopathologic examination of five lesions revealed a variety of findings, from an inflammatory infiltrate to a highly anaplastic pattern. The neoplastic cells expressed Ki-1 and leukocyte common antigens. Ultrastructurally, those cells showed ruffled indentations. The differential diagnosis includes microvillous malignant lymphoma. The patient has had a four-year follow-up without relapses.
Bittencourt
A L
AL
Department of Pathology, Hospital Martagão Gesteira, Salvador, Bahia, Brazil.
Mendonça
N
N
de Freitas
L A
LA
Schnitzer
B
B
D000008:Abdominal Neoplasms / Q000473:pathology; D015703:Antigens, CD / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D002467:Cell Nucleus / Q000648:ultrastructure; D002648:Child; D003593:Cytoplasm / Q000648:ultrastructure; D006801:Humans; D007124:Immunoenzyme Techniques; D017730:Ki-1 Antigen; D016403:Lymphoma, Large B-Cell, Diffuse / Q000737:chemistry / Q000473:pathology*; D008297:Male; D009365:Neoplasm Regression, Spontaneous / Q000473:pathology*; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology*
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D017730:Ki-1 Antigen