[Neurotoxicity caused by cyclosporin A in renal transplantation in children].
Cyclosporine is a specially useful immunosuppressor agent in children subjected to renal transplantation, minimizing the deleterious effect of steroids on growth and the development of Cushing syndrome. However, side effects which require close supervision are well known, including liver, kidney and central nervous system toxicity. Seizures, cerebellar ataxia, aphasia, paresthesia and behavioral disorders are characteristic of the latter. Hypertension and hypomagnesemia have been identified as risk factors. In contrast to nephrotoxicity, CNS toxicity is not related to plasma levels of cyclosporine. In this paper 2 patients, 10 and 11 year old, manifesting cyclosporine neurotoxicity after renal transplant, are reported.
Rodríguez
E
E
Unidad de Nefrología, Hospital Luis Calvo Mackenna, Santiago de Chile.
Delucchi
A
A
Cano
F
F
D002545:Brain Ischemia / Q000139:chemically induced*; D002648:Child; D003480:Cushing Syndrome / Q000188:drug therapy; D016572:Cyclosporine / Q000009:adverse effects* / Q000627:therapeutic use; D004172:Diplopia / Q000139:chemically induced; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced*; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D011183:Postoperative Complications / Q000139:chemically induced* / Q000188:drug therapy; D011559:Pseudotumor Cerebri / Q000139:chemically induced*; D013345:Subarachnoid Hemorrhage / Q000139:chemically induced; D014657:Vasculitis / Q000139:chemically induced*
D016572:Cyclosporine
Neurotoxicidad por ciclosporina A en trasplante renal en niños.