Serum levels of cholesterol and ischemic heart disease mortality. The Värmland Study.
The objective of the Värmland Study was to examine how serum cholesterol can be used to predict short- and long-term ischemic heart disease (IHD) mortality, especially in women aged 65 or older. This prospective cohort study involved about 20 years of follow-up after a single determination of serum cholesterol and included participants in a health screening undertaken from 1962 to 1965 (48,076 men, 48,732 women). The main outcome measures were mortality from IHD, acute myocardial infarction (MI), and chronic ischemic heart disease (CIHD). An IHD mortality trend was associated with increasing cholesterol levels for people younger than 65 years, and was more pronounced for men than women. For people 65 years or older, there was a weak trend for men, but not even a tendency for women. Regarding acute MI, significant trends were observed for males as well as females, for young as well as old people. A mild CIHD mortality trend was observed for young men. Otherwise no significant trend was seen.
Eklund
G A
GA
Department of Cancer Epidemiology, Karolinska Hospital, Stockholm, Sweden.
Carstensen
J M
JM
Lindberg
G
G
Gullberg
B
B
Råstam
L
L
Törnberg
S A
SA
D000328:Adult; D000367:Age Factors; D000368:Aged; D002784:Cholesterol / Q000097:blood*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000401:mortality; D017202:Myocardial Ischemia / Q000097:blood / Q000401:mortality*; D011446:Prospective Studies; D012044:Regression Analysis; D012737:Sex Factors; D013548:Sweden / Q000453:epidemiology
D002784:Cholesterol