Human herpesvirus 6 (HHV-6) infection in the central nervous system.
Human herpesvirus 6 (HHV 6) was isolated from patients with exanthema subitum (ES) with a high frequency, and it is now believed that this virus causes ES as a primary infection in childhood. HHV 6 infection is highly prevalent in early childhood and this virus may infect infants through the saliva mainly from mother to child. HHV 6 has a tropism to CD4+ cells and destroys cells in vitro. Although children recover from ES without any sequelae, neurological symptoms associated with exanthema subitum are often observed, and we could detect HHV 6 in the cerebrospinal fluid of ES patients. This result suggests that HHV 6 may invade the central nervous system and cause neurological symptoms.
Yamanishi
K
K
Department of Virology, Osaka University, Japan.
Kondo
K
K
Mukai
T
T
Kondo
T
T
Nagafuji
H
H
Kato
T
T
Okuno
T
T
Kurata
T
T
D000914:Antibodies, Viral / Q000032:analysis / Q000276:immunology; D001927:Brain Diseases / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000382:microbiology*; D002555:Cerebrospinal Fluid / Q000382:microbiology*; D002675:Child, Preschool; D003588:Cytopathogenic Effect, Viral / Q000276:immunology; D005077:Exanthema Subitum / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000382:microbiology; D005455:Fluorescent Antibody Technique; D006566:Herpesviridae Infections / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000382:microbiology; D015654:Herpesvirus 6, Human / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D066298:In Vitro Techniques; D007223:Infant; D003294:Seizures, Febrile / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000382:microbiology
D000914:Antibodies, Viral