title: Activity of topically applied leukotriene B4 in experimental dermatophytosis.
abstract: In a pilot study to assess the antimycotic potential of the chemoattractant leukotriene B4 (LTB4), guinea pigs were infected with Trichophyton mentagrophytes var. mentagrophytes and divided into groups of untreated control animals or treated daily with LTB4, isoconazole nitrate or vehicle alone. The animals were assessed clinically, mycologically and histopathologically. Treatment with isoconazole nitrate was the most effective. The LTB4-treated group were clinically worse than the non-treated group and the mycological results remained positive throughout the assessment period.
authors.affiliation: Department of Dermatology, University of Glasgow, UK.
authors.forename: G S
authors.initials: GS
authors.lastname: Shankland
authors.forename: M D
authors.initials: MD
authors.lastname: Richardson
mesh_terms: D000818:Animals; D003881:Dermatomycoses / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D007975:Leukotriene B4 / Q000627:therapeutic use*; D014005:Tinea / Q000188:drug therapy*
chemical_list: D007975:Leukotriene B4