title: The need for clinical awareness of polymorphous low-grade adenocarcinoma: a review.
abstract: Adenocarcinomas of the salivary glands are a heterogeneous group both in terms of histomorphology and clinical course. One recently described adenocarcinoma, polymorphous low-grade adenocarcinoma (solely of minor salivary gland occurrence), is appropriately named. This neoplasm has a wide spectrum of histology and can resemble tumors such as pleomorphic adenoma and adenoid cystic carcinoma; both aspects can lead to diagnostic problems for the pathologist. As well, despite an infiltrative growth pattern, which frequently results in perineural invasion, this tumor has a low local recurrence rate and a remarkable infrequency of local or distant metastasis. In order to provide appropriate therapy for polymorphous low-grade adenocarcinoma, oral and head and neck surgeons must be familiar with this neoplasm.
authors.affiliation: Department of Otolaryngology, University of Toronto, Ontario, Canada.
authors.forename: L
authors.initials: L
authors.lastname: Norberg
authors.forename: I
authors.initials: I
authors.lastname: Dardick
mesh_terms: D000230:Adenocarcinoma / Q000145:classification / Q000175:diagnosis / Q000473:pathology*; D008949:Adenoma, Pleomorphic / Q000175:diagnosis; D003528:Carcinoma, Adenoid Cystic / Q000175:diagnosis; D003937:Diagnosis, Differential; D006801:Humans; D011379:Prognosis; D012468:Salivary Gland Neoplasms / Q000145:classification / Q000175:diagnosis / Q000473:pathology*