Changes in ligand binding to GABAA receptor sites in pacific salmon (Oncorhynchus) brain during spawning migration and "aging".
When several years old, pacific salmon return to the site of birth, to spawn. At this time, a rapid aging process begins and the fish die within a few weeks after reproducing. Age-related changes of high and low affinity GABA binding sites were studied in salmon brains at three different phases of the spawning migration, i.e. shortly after returning to the natal stream, at the time of spawning, and thereafter. High affinity GABA binding slightly increased while the fish deteriorated. The low affinity component showed a remarkable decrease in density and a concomitant increase in affinity during this final episode of salmon life.
Erdö
S L
SL
Center of Anatomy, School of Medicine, University of Goettingen, FRG.
Meyer
D L
DL
Malz
C R
CR
Hofmann
M H
MH
Ebbesson
S O
SO
D000375:Aging / Q000378:metabolism*; D000613:Aminobutyrates / Q000494:pharmacology; D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D001640:Bicuculline / Q000494:pharmacology; D001667:Binding, Competitive; D001921:Brain / Q000254:growth & development / Q000378:metabolism*; D005260:Female; D007555:Isoxazoles / Q000494:pharmacology; D007700:Kinetics; D008024:Ligands; D008297:Male; D009118:Muscimol / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000378:metabolism*; D012474:Salmon; D012726:Sexual Behavior, Animal; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D000613:Aminobutyrates; D000700:Analgesics; D007555:Isoxazoles; D008024:Ligands; D011963:Receptors, GABA-A; D009118:Muscimol; C005959:2,4-diaminobutyric acid; D005680:gamma-Aminobutyric Acid; D001418:Baclofen; C015542:gaboxadol; D001640:Bicuculline