title: Extensive hepatic necrosis in a premature infant.
abstract: A fatal case of fulminant hepatic failure that occurred in the neonatal period is reported in a premature infant born after 27 4/7-weeks' gestation. Immediately after birth the infant had severe hypoxia and hypotension resulting from birth asphyxia, hypovolemic shock, and septicemia. At autopsy, histological appearance of the liver showed virtually total hepatocellular necrosis without features of fibrosis. Although the exact cause of hepatocellular injury cannot be fully ascertained, it is assumed that hypoxia and hypotension must have been the predominant factors leading to massive hepatic necrosis.
authors.affiliation: Department of Pediatrics, University Hospital, Free University, Amsterdam, The Netherlands.
authors.forename: L A
authors.initials: LA
authors.lastname: Bemmel
authors.forename: W W
authors.initials: WW
authors.lastname: Hack
authors.forename: C A
authors.initials: CA
authors.lastname: Seldenrijk
authors.forename: C M
authors.initials: CM
authors.lastname: Kneepkens
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000410:Alanine Transaminase; D001219:Aspartate Aminotransferases; D001639:Bicarbonates / Q000627:therapeutic use; D003023:Cloxacillin / Q000627:therapeutic use; D004298:Dopamine / Q000627:therapeutic use; D005260:Female; D005311:Fetal Hypoxia / Q000150:complications; D005322:Premature Rupture of Fetal Membranes; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000473:pathology*; D008099:Liver / Q000473:pathology*; D008297:Male; D009336:Necrosis / Q000209:etiology; D009428:Netilmicin / Q000627:therapeutic use; D010197:Pancuronium / Q000627:therapeutic use; D010314:Partial Thromboplastin Time; D010406:Penicillins / Q000627:therapeutic use; D011247:Pregnancy; D011517:Prothrombin Time; D018805:Sepsis / Q000188:drug therapy; D012769:Shock / Q000150:complications / Q000188:drug therapy; D012964:Sodium / Q000627:therapeutic use; D017693:Sodium Bicarbonate
chemical_list: D001639:Bicarbonates; D010406:Penicillins; D009428:Netilmicin; D017693:Sodium Bicarbonate; D012964:Sodium; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D010197:Pancuronium; D003023:Cloxacillin; D004298:Dopamine; D000212:Acyclovir