title: Beta-adrenoceptor modulation in a case of pure autonomic failure.
abstract: In a patient with pure autonomic failure, exercise did not modify beta-adrenoceptor density, probably due to an insufficient increase in plasma catecholamines. Isoproterenol infusion increased the number of beta-adrenoceptor by only 17%. Since in control subjects an increased beta-adrenoceptor level was found, following both physical stress and isoproterenol infusion, we suggest that the lack of increased beta-adrenoceptor levels may contribute to the poor circulatory adjustments observed in autonomic dysfunction during activities involving the sympathetic nervous system.
authors.affiliation: Department of Medicine, 2nd Medical School, University of Naples, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Perna
authors.forename: R
authors.initials: R
authors.lastname: Leone
authors.forename: M J
authors.initials: MJ
authors.lastname: Farace
authors.forename: V
authors.initials: V
authors.lastname: Brescia-Morra
authors.forename: G
authors.initials: G
authors.lastname: Campanella
authors.forename: G
authors.initials: G
authors.lastname: Brevetti
mesh_terms: D001342:Autonomic Nervous System Diseases / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology; D002395:Catecholamines / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D015444:Exercise / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D011311:Pressoreceptors / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology*
chemical_list: D002395:Catecholamines; D011943:Receptors, Adrenergic, beta; D007545:Isoproterenol