AZT-induced mitochondrial myopathy.
Histochemical, electron microscopy and biochemical studies were performed on muscle biopsy specimens from 11 AIDS patients treated with zidovudine. A peculiar association of structural abnormalities and mitochondrial dysfunction was found. Focal cytochrome c oxidase (COX) deficiency was evident in muscle sections from 9 patients, 8 of whom had received long-term treatment while one had been treated for 1 month only. Electron microscopy showed changes in number, size and structure of mitochondria. Biochemical studies proved partial COX and succinate cytochrome c reductase (SCR) deficiency in 4 patients; one patient had only reduced SCR activity. Our data confirm that AZT therapy can cause toxic myopathy with mitochondrial dysfunction.
Tomelleri
G
G
Istituto di Neurologia, Università di Verona.
Tonin
P
P
Spadaro
M
M
Tilia
G
G
Orrico
D
D
Barelli
A
A
Bonetti
B
B
Monaco
S
S
Salviati
A
A
Morocutti
C
C
D000328:Adult; D003576:Electron Transport Complex IV / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D008931:Mitochondria, Muscle / Q000201:enzymology* / Q000648:ultrastructure; D017240:Mitochondrial Myopathies / Q000139:chemically induced* / Q000201:enzymology; D009132:Muscles / Q000201:enzymology / Q000648:ultrastructure; D013384:Succinate Cytochrome c Oxidoreductase / Q000378:metabolism; D015215:Zidovudine / Q000009:adverse effects*
D015215:Zidovudine; D013384:Succinate Cytochrome c Oxidoreductase; D003576:Electron Transport Complex IV