Colposcopy staging and treatment of papillomavirus infection of the cervix.
The specificity of colposcopy findings in HPV infections allows the colposcopic differentiation of these lesions. In all of these colposcopically selected cases, additional tests included cytology with immunoperoxidase reaction (IPR), and, recently, virus typing with the use of ViraPap HPV DNA Detection test and ViraType HPV DNA Typing test became also available. When needed, histological examination of the specimen was carried out. In 202 detected and treated cases of HPV infections in females, and in 5 in males, four groups of lesions have been colposcopically distinguished. Group I contains early and fully developed, unsuspected typical papillomas; Group II--atypical papillomas which are usually colposcopically suspected of CIN and/or cancer; Group III--the so-called subclinical forms, i.e. cases with secondary diminution of epithelial transparency, i.e. acetic acid white epithelium, secondary simple punctuation and/or mosaic (flat condylomas) that are visible only in colposcopic magnification and usually suspected of CIN; and Group IV--the so-called latent lesions without any colposcopic findings and only with positive IPR. CIN 3 (including CIS) was determined histologically in five cases of Group II, and CIN 1-2 in ten cases of Group III. HPV virus type 16/18 was found only in cases of CIN 3. The cases of atypical papilloma (Group II) and recently those containing HPV virus type 16/18 were treated by means of surgical conisation or cryosurgery. The remaining cases (Groups I, II, IV) were treated with orally administered Tetracycline and Vitamin A. The effectiveness of this antibiotic/vitamin therapy in the group of typical papilloma and subclinical HPV lesions amounted to 75%.(ABSTRACT TRUNCATED AT 250 WORDS)
Madej
J
J
First Department of Gynecology, Medical Academy, Kraków, Poland.
Basta
A
A
Madej
J G
JG
Strama
M
M
D003127:Colposcopy; D005260:Female; D006801:Humans; D027383:Papillomaviridae; D013752:Tetracycline / Q000627:therapeutic use; D014412:Tumor Virus Infections / Q000175:diagnosis* / Q000188:drug therapy; D002577:Uterine Cervical Diseases / Q000175:diagnosis* / Q000188:drug therapy; D014801:Vitamin A / Q000627:therapeutic use
D014801:Vitamin A; D013752:Tetracycline