[Disorders of sorbitol and myoinositol metabolism and the activity of sodium, potassium ATPase in the pathogenesis of peripheral neuropathy in patients with diabetes mellitus].
Authors discussed the actual status of information concerning the disturbances in function: 1) of sorbitol biochemical pathway, 2) myoinositol metabolism and 3) activity of Na(+)-K(+)-ATP-ase related to diabetic hyperglycemia. Preliminary data on the possible benefit of aldo-reductase inhibitors therapy are also presented.
Mosiewicz
J
J
I Katedry i Kliniki Chorób Wewnetrznych AM, Lublinie.
Grzywa
M
M
D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism*; D003929:Diabetic Neuropathies / Q000209:etiology*; D006801:Humans; D007294:Inositol / Q000378:metabolism*; D010525:Peripheral Nerves / Q000378:metabolism*; D010523:Peripheral Nervous System Diseases / Q000209:etiology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000172:deficiency*; D013012:Sorbitol / Q000378:metabolism*
D007294:Inositol; D013012:Sorbitol; D000254:Sodium-Potassium-Exchanging ATPase
Zaburzenia metabolizmu sorbitolu i mioinozytolu oraz czynności ATPazy sodowo-potasowej w patogenezie neuropatii obwodowej u chorych na cukrzyce.