123I-iomazenil: a quantitative study of the central benzodiazepine receptor distribution.
Fourteen patients with temporal lobe epilepsy, 9 patients after amygdalohippocampectomy and 3 healthy volunteers were examined with the new benzodiazepine receptor marker 123I-Iomazenil and SPECT. For comparison perfusion SPECT studies with 99mTc-HMPAO were done and a quantitative ROI analysis of the data performed. This quantitative analysis consisted of calculation of right-to-left ratios for 123I-Iomazenil SPECTs, whereby values of 1 were obtained with narrow standard deviations. ROI measurements of the medial occipital, frontal and parietal cortex, the cerebellum and white matter showed a pattern of benzodiazepine receptor concentration in concordance with that previously found in PET and autoradiographic studies, if 123I-Iomazenil ROIs were normalized to the corresponding 99mTc-HMPAO ROIs. The abnormal distribution in the temporal lobes will not be discussed in this paper.
Haldemann
R C
RC
Department of Medical Radiology, University Hospital, Zurich, Switzerland.
Bicik
I
I
Pfeiffer
A
A
Wieser
H G
HG
Hasler
P H
PH
Schubiger
P
P
von Schulthess
G K
GK
D000328:Adult; D000368:Aged; D000679:Amygdala / Q000601:surgery; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging* / Q000601:surgery; D005260:Female; D005442:Flumazenil / Q000031:analogs & derivatives*; D006624:Hippocampus / Q000601:surgery; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010091:Oximes; D011963:Receptors, GABA-A / Q000032:analysis*; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
D007457:Iodine Radioisotopes; D015609:Organotechnetium Compounds; D010091:Oximes; D011963:Receptors, GABA-A; D019690:Technetium Tc 99m Exametazime; D005442:Flumazenil; C063038:iomazenil