title: A dietary fibre supplement in the treatment of mild hypertension. A randomized, double-blind, placebo-controlled trial.
abstract: OBJECTIVE
  To study the effects of a dietary fibre supplement given as monotherapy upon blood pressure in mildly hypertensive patients.
  
  
  METHODS
  The investigation was performed as a prospective randomized, double-blind, placebo-controlled trial for 3 months.
  
  
  METHODS
  Patients attending an outpatient hypertension clinic in a hospital.
  
  
  METHODS
  Hypertensive patients with a minimum of two diastolic blood pressure (DBP) readings greater than 90 mmHg during a 2-week run-in period were included. Of the 65 patients enrolled, 63 were randomized (32 fibre, 31 placebo). Six patients did not complete the trial.
  
  
  METHODS
  Patients were treated with either fibre (7 g/day) or matching placebo.
  
  
  METHODS
  Based on previous studies, the a priori hypothesis was that dietary fibre supplementation could reduce blood pressure in hypertensive patients.
  
  
  RESULTS
  Body weight was significantly reduced in the fibre group. Dietary fibre significantly reduced DBP and fasting serum insulin. However, no correlation between changes in body weight and systolic blood pressure or DBP was found.
  
  
  CONCLUSIONS
  A dietary fibre supplement can lower DBP in mildly hypertensive patients independent of changes in body weight.
authors.affiliation: Department of Internal Medicine, Karolinska Hospital, Stockholm, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Eliasson
authors.forename: K R
authors.initials: KR
authors.lastname: Ryttig
authors.forename: B
authors.initials: B
authors.lastname: Hylander
authors.forename: S
authors.initials: S
authors.lastname: Rössner
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D004043:Dietary Fiber / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000178:diet therapy* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors; D015431:Weight Loss