Possible identity of kallikrein binding protein with protein C inhibitor.
Protein C inhibitor (PCI) inhibits tissue kallikrein by forming stable 1:1 complexes (k1 = 2.3 x 10(4)M-1s-1). Heparin inhibits the tissue kallikrein/PCI-interaction and complex formation of 125I-tissue kallikrein in serum. 125I-tissue kallikrein complexes formed in plasma can be immunoprecipitated with monoclonal anti-PCI IgG suggesting that PCI might be identical to the kallikrein binding protein described previously (J. Chao et al. 1986, Biochem. J. 239, 325-331).
Ecke
S
S
Laboratory for Clinical Experimental Physiology, University of Vienna, Austria.
Geiger
M
M
Resch
I
I
Jerabek
I
I
Maier
M
M
Binder
B R
BR
D002352:Carrier Proteins / Q000302:isolation & purification*; D011232:Chemical Precipitation; D006801:Humans; D066298:In Vitro Techniques; D007610:Kallikreins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015849:Plasminogen Inactivators / Q000302:isolation & purification* / Q000494:pharmacology / Q000652:urine; D011486:Protein C / Q000037:antagonists & inhibitors; D018046:Protein C Inhibitor; D015842:Serine Proteinase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology
D002352:Carrier Proteins; D015849:Plasminogen Inactivators; D011486:Protein C; D018046:Protein C Inhibitor; D015842:Serine Proteinase Inhibitors; D007610:Kallikreins