Are Wistar rats not susceptible to organophosphate-induced delayed neurotoxicity?
Male Wistar rats were sacrificed 12 weeks after single exposure to various organophosphate compounds. Peripheral nerves and skeletal muscles were examined light microscopically for the occurrence of a delayed polyneuropathy. Although unequivocal morphological hallmarks of OPIDN had been demonstrated in other rat strains using similar doses of TOCP or mipafox, we were unable to demonstrate any abnormality with these compounds. Normal findings were also obtained with fenthion, the delayed neuropathic potential of which is debated, and with paraoxon or parathion, which are both highly unlikely to cause OPIDN. These data indicate that the Wistar rat strain is highly likely to be resistant to OPIDN.
De Bleecker
J L
JL
Neurology Department, University Hospital, Ghent, Belgium.
Van Den Abeele
K G
KG
Willems
J L
JL
De Reuck
J L
JL
D000818:Animals; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D008297:Male; D009943:Organophosphorus Compounds / Q000633:toxicity*; D010525:Peripheral Nerves; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D051381:Rats; D017208:Rats, Wistar
D009943:Organophosphorus Compounds