[Angiotensin converting enzyme index increases after open cardiac surgery].
To investigate whether pulmonary endothelial cells are damaged after open cardiac, open chest, or head-neck surgery, we measured angiotensin converting enzyme (ACE) and calculated ACE index (ACE.cardiac output-1) to exclude the influence of pulmonary perfusion volume in 38 patients. There were no significant differences among three groups in serum ACE (9.93 +/- 2.46 IU.l-1 after open cardiac surgery, 8.50 +/- 2.75 IU.l-1 after open chest surgery, 10.71 +/- 2.23 IU.l-1 after head-neck surgery). ACE index after open cardiac surgery was significantly higher than those after open chest and head-neck surgery (2.43 +/- 0.85, 1.67 +/- 0.69, 1.64 +/- 0.50 respectively). These results suggest that ACE index detects pulmonary endothelial cell damage caused by reperfusion after cardiopulmonary bypass. We conclude that ACE index is more useful than ACE as an early clinical marker of pulmonary endothelial cell damage.
Kayaba
M
M
Department of Anesthesiology, Akita University School of Medicine.
Enzan
K
K
Suzuki
M
M
D000368:Aged; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D006801:Humans; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood*
D007703:Peptidyl-Dipeptidase A