Pituitary adenoma proliferative indices and risk of recurrence.
Twenty unselected pituitary adenomas have been examined for proliferative indices (PIs), and anterior pituitary hormone expression. All but two of the tumours were non-functional with proliferative indices from less than 0.1 to 0.5%. Two tumours were null cell adenomas with PIs less than 0.1 and 0.2%. The PIs of the three recurrent tumours was less than 1.0%. Gonadotrophin and TSH immunoreactivity was heterogenous and was found in 12/20 (60%) of the tumours. There was no significant relationship between PI, hormone expression or any other measured parameter. The biological behaviour of pituitary adenomas with a PI of less than 0.1% is uncertain, but those with a PI of greater than 0.1% are more likely to recur although longer follow-up is needed to confirm this.
Carboni
P
P
Department of Neurosurgery, Midland Centre for Neurosurgery and Neurology.
Detta
A
A
Hitchcock
E R
ER
Postans
R
R
D000236:Adenoma / Q000097:blood / Q000378:metabolism / Q000473:pathology*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000368:Aged; D001973:Bromodeoxyuridine; D002455:Cell Division; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D010911:Pituitary Neoplasms / Q000097:blood / Q000378:metabolism / Q000473:pathology*; D011388:Prolactin / Q000097:blood; D012307:Risk Factors
D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D001973:Bromodeoxyuridine