title: [European Acute Transfusion Hepatitis Interferon Study (EATHIS)].
abstract: Since 1989, a prospective, multicentric and collaborative study, named European Acute Transfusion Hepatitis Interferon Study (EATHIS), involving 16 blood centres in France is coordinated by a task force in collaboration with the Viral Hepatitis and Recipients working groups of the French National Society of Blood Transfusion. A phase of recipient screening may be completed by a therapeutic interferon protocol. Among 1,476 transfused recipients receiving an average of 4.4 blood components, 1,011 were followed up at least four months. The incidence of non-A, non-B post-transfusion hepatitis (PTH) was varying from 0.1 to 6% at the different locations. Out of 15 hepatitis cases, 10 were diagnosed as post-transfusional. These preliminary data indicate a reduced incidence of PTH, with a mean of 1% for the period 1989-1991. It emphasises the importance of a transfusion vigilance program including follow up and testing for transaminases and specific viral markers.
authors.affiliation: Centre National de Transfusion Sanguine, Hôpital Saint-Antoine, Paris.
authors.forename: A M
authors.initials: AM
authors.lastname: Jullien
authors.forename: A M
authors.initials: AM
authors.lastname: Dejean
authors.forename: C
authors.initials: C
authors.lastname: Janot
authors.forename: C
authors.initials: C
authors.lastname: Trepo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D015415:Biomarkers; D004796:Clinical Enzyme Tests; D005602:France / Q000453:epidemiology; D016174:Hepacivirus / Q000276:immunology; D006508:Hepatitis Antibodies / Q000097:blood; D006526:Hepatitis C / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control / Q000635:transmission*; D006801:Humans; D015994:Incidence; D008403:Mass Screening; D008875:Middle Aged; D011446:Prospective Studies; D065227:Transfusion Reaction
chemical_list: D015415:Biomarkers; D006508:Hepatitis Antibodies; D000410:Alanine Transaminase
vernacular_title: European Acute Transfusion Hepatitis Interferon Study (EATHIS).