title: Search for evidence of herpes simplex virus, type 1, or varicella-zoster virus infection in postmortem brain tissue from schizophrenic patients.
abstract: The highly sensitive polymerase chain reaction (PCR) was used to search for herpes simplex virus type 1 (HSV-I) or varicella-zoster virus (VZV) in the DNA extracted from postmortem temporal cortex samples of 8 schizophrenic subjects, 8 nonschizophrenic suicide victims and 8 normal controls. HSV-I or VZV-specific DNA amplification was not detected in any of the samples studied.
authors.affiliation: Department of Psychiatry and Human Behavior, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107.
authors.forename: R C
authors.initials: RC
authors.lastname: Alexander
authors.forename: G
authors.initials: G
authors.lastname: Cabirac
authors.forename: T
authors.initials: T
authors.lastname: Lowenkopf
authors.forename: M
authors.initials: M
authors.lastname: Casanova
authors.forename: J
authors.initials: J
authors.lastname: Kleinman
authors.forename: R J
authors.initials: RJ
authors.lastname: Wyatt
authors.forename: D G
authors.initials: DG
authors.lastname: Kirch
mesh_terms: D001483:Base Sequence; D005260:Female; D014645:Herpesvirus 3, Human / Q000276:immunology*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012559:Schizophrenia / Q000473:pathology*; D018139:Simplexvirus / Q000276:immunology*; D013405:Suicide; D013702:Temporal Lobe / Q000473:pathology*