Preliminary characterization of hereditary cerebellar ataxia in rats.
A spontaneous model of Purkinje cell degeneration in rats is described. Breeding data indicate that the condition is hereditary and not sex linked. The breeding colony has remained free of common murine pathogens, including parvovirus. In older rats with pronounced ataxia, the major lesions consisted of greatly reduced numbers or complete absence of Purkinje cells (PCs), particularly in the anterior lobe of the cerebellum. There was a decreased thickness and increased cellular density of the molecular layer and degeneration of the inferior olivary nuclei. Morphometric analysis indicated that the anterior lobes of affected rats were 52% smaller than those of normal rats. In young rats, before severe signs of ataxia had developed, microscopic changes were minimal. The preliminary findings are discussed in relationship to human cerebellar ataxias and mouse models of Purkinje cell degeneration.
La Regina
M C
MC
Department of Comparative Medicine, St. Louis University School of Medicine, MO 63104.
Yates-Siilata
K
K
Woods
L
L
Tolbert
D
D
D000818:Animals; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D001947:Breeding; D002524:Cerebellar Ataxia / Q000097:blood / Q000235:genetics / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D008099:Liver / Q000473:pathology; D008297:Male; D009043:Motor Activity; D011689:Purkinje Cells / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013132:Spinocerebellar Degenerations / Q000097:blood / Q000235:genetics / Q000473:pathology*