title: Urethral reconstruction with a new synthetic absorbable device. An experimental study.
abstract: Four centimeters of the canine urethra was replaced by a graft consisting of a polyglactin fiber mesh tube, coated with polyhydroxybutyric acid. Microscopic examination 8-12 months later showed almost complete regeneration of the urethral epithelium and the adjacent connective tissue. The neo-urethra was patent and there were no anastomotic strictures, nor was there any inflammatory reaction around the urethra. The validity of this concept in humans remains to be proved.
authors.affiliation: Department of Pediatric Surgery, University Hospital, Uppsala, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Olsen
authors.forename: S
authors.initials: S
authors.lastname: Bowald
authors.forename: C
authors.initials: C
authors.lastname: Busch
authors.forename: J
authors.initials: J
authors.lastname: Carlsten
authors.forename: I
authors.initials: I
authors.lastname: Eriksson
mesh_terms: D000818:Animals; D004285:Dogs; D006885:Hydroxybutyrates; D008297:Male; D011100:Polyglycolic Acid; D019736:Prostheses and Implants; D011474:Prosthesis Design; D012038:Regeneration / Q000502:physiology*; D014521:Urethra / Q000473:pathology / Q000601:surgery*; D014945:Wound Healing / Q000502:physiology
chemical_list: D006885:Hydroxybutyrates; D011100:Polyglycolic Acid