title: Serotonin-stimulated phosphoinositide hydrolysis in platelets from post-withdrawal alcoholics.
abstract: It has previously been reported that serotonin-stimulated second messenger formation is inhibited in platelets from alcoholics undergoing detoxification. Serotonin-stimulated signal transduction was therefore analysed in platelets from young post-withdrawal alcoholics to elucidate whether the previously reported inhibition is a state or trait marker of alcoholism. No difference between post-withdrawal alcoholics and controls was found with regard to serotonin-stimulated [32P]-phosphatidylinositol 4,5-bisphosphate hydrolysis or [32P]-phosphatidic acid formation. The results indicate that the inhibited serotonin2 receptor function seen in alcoholics undergoing detoxification is a state-dependent rather than a trait-dependent marker.
authors.affiliation: Department of Psychiatry, Lund University, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Simonsson
authors.forename: M
authors.initials: M
authors.lastname: Berglund
authors.forename: L
authors.initials: L
authors.lastname: Oreland
authors.forename: A L
authors.initials: AL
authors.lastname: Moberg
authors.forename: C
authors.initials: C
authors.lastname: Alling
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000097:blood*; D001792:Blood Platelets / Q000187:drug effects; D000431:Ethanol / Q000009:adverse effects; D006801:Humans; D006868:Hydrolysis; D008297:Male; D010716:Phosphatidylinositols / Q000096:biosynthesis*; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000097:blood*
chemical_list: D010716:Phosphatidylinositols; D011985:Receptors, Serotonin; D012701:Serotonin; D000431:Ethanol