Immunological side effects of some long term taking medicaments.
In view of epidemiologic aspects of AIDS we studied the immunological side-effects of oral hormonal contraceptives and the barbiturates--which are used by many people in Hungary. We studied healthy persons using more than six months one of the above described drugs. We found significant decrease in the number of "O" cells and in the serum concentration of IgG in the O.C. test group. In B test group decreased significantly the number of T, B, T-active, T-helper lymphocytes and the serum concentration of IgM. The amount of IgA and IgD increased in both the test groups. We detected HBV-markers only in 0.83% of control-group but in 4.23% of O.C. group and in 2.28% of the B test group. The data suggests that all of studied medicaments cause increase in susceptibility against infections.
Nagylucskay
S
S
Institute of Hygiene and Epidemiology, Semmelweis, University of Medicine, Budapest, Hungary.
Vedres
I
I
Lelkes
M
M
Mádi-Szabó
L
L
Pálfi
I
I
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D000293:Adolescent; D000328:Adult; D001463:Barbiturates / Q000009:adverse effects*; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects* / Q000276:immunology; D005260:Female; D006679:HIV Seropositivity / Q000276:immunology; D006513:Hepatitis B e Antigens / Q000097:blood / Q000276:immunology; D006801:Humans; D007109:Immunity / Q000187:drug effects*; D007136:Immunoglobulins / Q000097:blood / Q000276:immunology; D007958:Leukocyte Count; D008297:Male; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D001463:Barbiturates; D003278:Contraceptives, Oral, Hormonal; D006513:Hepatitis B e Antigens; D007136:Immunoglobulins