A comparative trial of lisinopril and nifedipine in mild to moderate hypertension in general practice.
OBJECTIVE
to compare lisinopril and nifedipine in the management of essential hypertension in 52 patients in general practice with respect to the obtaining of target diastolic blood pressure and freedom from side effects.


METHODS
an open label, parallel randomised trial over an eight week period.


RESULTS
lisinopril and nifedipine were found to effectively lower diastolic blood pressure with the latter having a significantly higher level of withdrawals and clinical side effects.


CONCLUSIONS
lisinopril is equivalent to nifedipine in its hypertensive effect and has a better side effect profile.
Murdoch
J C
JC
Department of General Practice, University of Otago Medical School, Dunedin.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D015982:Bias; D004656:Enalapril / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005194:Family Practice; D005260:Female; D006801:Humans; D006973:Hypertension / Q000145:classification / Q000188:drug therapy* / Q000503:physiopathology; D017706:Lisinopril; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011446:Prospective Studies; D012720:Severity of Illness Index
D000959:Antihypertensive Agents; D004656:Enalapril; D017706:Lisinopril; D009543:Nifedipine