[The effect of activation and blockade of the renin-angiotensin system on the hypotensive activity of the cholinergic system].
In anesthetised rats, infusion of angiotensin II increased mean arterial pressure and inhibited the depressor responses to acetylcholine administration. Low doses of angiotensin did not exert this effect. This and other data obtained suggest that angiotensin II inhibits cardiovascular effects of the cholinergic system tonically.
Fedorov
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D000109:Acetylcholine / Q000494:pharmacology; D000804:Angiotensin II / Q000494:pharmacology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D002216:Captopril / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D007022:Hypotension / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D009388:Neostigmine / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology; D051381:Rats; D011950:Receptors, Cholinergic / Q000187:drug effects* / Q000502:physiology; D012084:Renin-Angiotensin System / Q000187:drug effects* / Q000502:physiology; D012504:Saralasin / Q000494:pharmacology; D013722:Teprotide; D013997:Time Factors
D000806:Angiotensin-Converting Enzyme Inhibitors; D009842:Oligopeptides; D011950:Receptors, Cholinergic; D000804:Angiotensin II; D009388:Neostigmine; D002216:Captopril; D013722:Teprotide; D012504:Saralasin; D000109:Acetylcholine
Vliianie aktivizatsii i blokady renin-angiotenzinnoĭ sistemy na gipotenzivnuiu aktivnost' kholinergicheskoĭ sistemy.