[The expression and significance of blood group antigens (BGA) A, B, H, Le(a) and Le(b) in hepatocellular carcinoma and chronic hepatitis].
Five monoclonal antibodies which selectively recognize A, B, H, Le(a) and Le(b) BGA had been used for immunohistochemical examination of serial sections collected from 40 cases of hepatocellular carcinomas, 63 cases of chronic hepatitis, 10 cases each of fetal and normal adult liver. All of the cases had been followed-up except the autopsy cases. The results were as follows: in fetal and normal adult liver tissues, none of the liver BGA were detected in the parenchymal liver cells. Five BGA were expressed in 11 hepatitic cases (17%) and also expressed in 19 hepatocellular carcinomas (48%). Combining the expression of BGA with the follow-up results, the study we have performed indicates that the expression of BGA in chronic hepatitis predicts cancerous change or severe liver cell damage associated with poor prognosis.
Lin
X S
XS
Cancer Research Laboratory, PLA General Hospital, Beijing.
D000017:ABO Blood-Group System / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000276:immunology*; D006505:Hepatitis / Q000276:immunology*; D006801:Humans; D007519:Isoantigens / Q000276:immunology; D007983:Lewis Blood Group Antigens / Q000276:immunology*; D008113:Liver Neoplasms / Q000276:immunology*
D000017:ABO Blood-Group System; D000911:Antibodies, Monoclonal; D007519:Isoantigens; D007983:Lewis Blood Group Antigens