title: Putative novel bradykinin B3 receptors in the smooth muscle of the guinea-pig taenia caeci and trachea.
abstract: The bradykinin receptors mediating contraction in smooth muscle of the guinea-pig taenia caeci were compared with the proposed novel B3 receptors of the guinea-pig trachea. The activities of several antagonists in functional and binding studies were found to be very similar between these two guinea-pig preparations, but pKBs were markedly lower than in a number of typical B2 preparations from other species, suggesting that the characteristics of the proposed B3 receptor may be in part species-related.
authors.affiliation: Biomedical Sciences Division, King's College London, London, UK.
authors.forename: J L
authors.initials: JL
authors.lastname: Field
authors.forename: J M
authors.initials: JM
authors.lastname: Hall
authors.forename: I K
authors.initials: IK
authors.lastname: Morton
mesh_terms: D000818:Animals; D001920:Bradykinin / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000494:pharmacology; D002432:Cecum / Q000378:metabolism; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007700:Kinetics; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000378:metabolism*; D018002:Receptors, Bradykinin; D017981:Receptors, Neurotransmitter / Q000037:antagonists & inhibitors / Q000145:classification / Q000378:metabolism*; D013045:Species Specificity; D014018:Tissue Distribution; D014132:Trachea / Q000378:metabolism
chemical_list: D018002:Receptors, Bradykinin; D017981:Receptors, Neurotransmitter; D001920:Bradykinin