title: Epstein-Barr virus-transformed B lymphocytes produce low molecular mass molecules with autocrine growth factor and competence factor activity.
abstract: A human Epstein-Barr virus (EBV)-positive lymphoblastoid B cell line, named BA-D10-4, produces a factor of a molecular mass less than 10 kDa that promotes cell proliferation of both BA-D10-4 cells and other human T or B lymphoid cell lines, either EBV-positive or -negative. The factor synergizes with higher molecular mass autocrine growth factors and makes both BA-D10-4 cells and B cell lines from Burkitt's lymphoma, but not cells from T cell leukemia, more responsive to interleukin-1 and interleukin-6. Therefore, this low molecular mass factor seems to be an autocrine growth factor per se and to have the characteristics of a competence factor.
authors.affiliation: Department of Biomedicine, University of Pisa, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Garzelli
authors.forename: A
authors.initials: A
authors.lastname: Bazzichi
authors.forename: A M
authors.initials: AM
authors.lastname: Dayah
authors.forename: M
authors.initials: M
authors.lastname: Manunta
authors.forename: M
authors.initials: M
authors.lastname: Incaprera
authors.forename: G
authors.initials: G
authors.lastname: Falcone
mesh_terms: D001402:B-Lymphocytes / Q000378:metabolism*; D002461:Cell Line, Transformed; D002850:Chromatography, Gel; D004247:DNA / Q000096:biosynthesis; D006133:Growth Substances / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology; D004854:Herpesvirus 4, Human; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology; D015850:Interleukin-6 / Q000494:pharmacology; D008970:Molecular Weight
chemical_list: D006133:Growth Substances; D007375:Interleukin-1; D015850:Interleukin-6; D004247:DNA