Induction of chromosomal aberrations in bone marrow cells of asbestotic rats.
In the present study, cytogenetic effects of Indian chrysotile asbestos in rat bone marrow cells after 290 days of intratracheal inoculation (5 mg dust/0.5 ml normal saline), when it develops massive pulmonary fibrosis, were investigated. The pulmonary fibrosis was confirmed by both histopathological studies and increased collagen content in the lung of the treated animals. In the asbestotic rats a significant increase in chromosomal aberrations was recorded and a decrease in mitotic index of bone marrow cells. The types of chromosomal aberrations in these cells were chromatid gaps and breaks. The results indicate the significant cytogenetic changes in the bone marrow cells of asbestotic rats and also suggest that these changes directly or indirectly may be one of the biological events involved in eliciting the asbestos-mediated toxic responses.
Fatma
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N
Fibre Toxicology Division, Industrial Toxicology Research Centre, Lucknow, India.
Khan
S G
SG
Aslam
M
M
Rahman
Q
Q
D000818:Animals; D001194:Asbestos / Q000009:adverse effects; D017632:Asbestos, Serpentine; D001195:Asbestosis / Q000235:genetics*; D001853:Bone Marrow / Q000473:pathology*; D002842:Chromatids / Q000473:pathology; D002869:Chromosome Aberrations; D005260:Female; D008940:Mitotic Index; D051381:Rats
D017632:Asbestos, Serpentine; D001194:Asbestos