Effect of Pre-S1 protein on the long-term cultures of human lymphocytes after hepatitis B immunization.
Long-term cultured T-cells, reactive to Pre-S1 protein, were developed from peripheral blood mononuclear cells (PBMC) of individuals after recovery from hepatitis B infection and of vaccine recipients by in vitro Pre-S1 protein stimulation in the presence of IL-2. The proliferative responses to Pre-S1 protein and functional activities of cultured T-cells were characterized.
Sułowska
Z
Z
Microbiology and Virology Center, Polish Academy of Sciences, Lódź.
Tchórzewski
H
H
Sidorkiewicz
M
M
Płucienniczak
A
A
D002478:Cells, Cultured; D006509:Hepatitis B / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D017325:Hepatitis B Vaccines / Q000276:immunology; D006801:Humans; D007114:Immunization; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D011498:Protein Precursors / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology
C075654:Engerix-B; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D010835:Phytohemagglutinins; D011498:Protein Precursors; D014614:Vaccines, Synthetic; C028784:phytohemagglutinin-P; C050806:presurface protein 1, hepatitis B surface antigen