title: Polysialic acid influences specific pathfinding by avian motoneurons.
abstract: The influence of polysialic acid (PSA) on the neural cell adhesion molecule on motoneuron outgrowth and pathway formation was investigated by determining its temporal and spatial pattern of expression and by the effect that its removal had on motoneuron projection patterns. Motoneurons first expressed PSA as their growth cones began to segregate into motoneuron pool-specific groups in the plexus region; furthermore, PSA levels differed between motoneurons projecting to different targets. When PSA was removed during the period of axonal segregation in the plexus region projection errors were common. However, later removal during the process of muscle nerve formation did not result in projection errors. These results suggest that PSA modulates interactions between motoneuron axons and guidance molecules in the plexus region during axonal pathfinding.
authors.affiliation: Department of Physiology and Neurobiology, University of Connecticut, Storrs 06269-3042.
authors.forename: J
authors.initials: J
authors.lastname: Tang
authors.forename: L
authors.initials: L
authors.lastname: Landmesser
authors.forename: U
authors.initials: U
authors.lastname: Rutishauser
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology; D015816:Cell Adhesion Molecules, Neuronal / Q000378:metabolism; D002642:Chick Embryo / Q000502:physiology*; D005314:Embryonic and Fetal Development; D007267:Injections; D009046:Motor Neurons / Q000378:metabolism / Q000502:physiology*; D009132:Muscles / Q000294:innervation; D009434:Neural Pathways / Q000187:drug effects; D009439:Neuraminidase / Q000494:pharmacology; D010063:Ovum; D010525:Peripheral Nerves / Q000378:metabolism; D012794:Sialic Acids / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013116:Spinal Cord / Q000378:metabolism; D009435:Synaptic Transmission
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D012794:Sialic Acids; C021319:polysialic acid; D009439:Neuraminidase