title: Location and characterization of the bovine herpesvirus type 4 thymidine kinase gene; comparison with thymidine kinase genes of other herpesviruses.
abstract: The location and nucleotide sequence of the bovine herpesvirus type 4 (BHV-4) thymidine kinase (TK) gene was determined. The coding region of the TK gene is 1335 nucleotides long and corresponds to a polypeptide of 445 amino acids. Comparison of TK amino acid sequences of BHV-4 and 16 herpesvirus TKs reveals a greater homology to those of the gammaherpesviruses EBV and specially HVS, than to those of alphaherpesviruses. The open reading frames detected in the vicinity of TK gene were homologous to the corresponding ones in other herpesviruses.
authors.affiliation: Virology Department, Faculty of Veterinary Medicine, University of Liège, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Lomonte
authors.forename: M
authors.initials: M
authors.lastname: Bublot
authors.forename: P P
authors.initials: PP
authors.lastname: Pastoret
authors.forename: E
authors.initials: E
authors.lastname: Thiry
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle / Q000382:microbiology*; D004279:DNA, Viral / Q000235:genetics; D005814:Genes, Viral; D006564:Herpesviridae / Q000201:enzymology / Q000235:genetics*; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D016415:Sequence Alignment; D013045:Species Specificity; D013937:Thymidine Kinase / Q000235:genetics*; D015678:Viral Structural Proteins / Q000235:genetics*
chemical_list: D004279:DNA, Viral; D015678:Viral Structural Proteins; D013937:Thymidine Kinase