Effects of gamma-linolenic acid on mitosis and nuclear morphology in osteogenic sarcoma cells.
In this study it is shown that gamma-linolenic acid (GLA) at concentrations of 10, 20 and 50 micrograms/ml has a dose-responsive inhibitory effect on mitosis in osteogenic sarcoma cells after exposure for 24, 48 and 72 hours, respectively. GLA also has marked effects on the morphology of the nucleus and nucleolus of these cells. Decreased silver staining of nuclear phosphoproteins was also evident in GLA-supplemented cells.
de Kock
M
M
Department of Physiology, University of South Africa, Pretoria.
Seegers
J C
JC
Els
H J
HJ
D000970:Antineoplastic Agents / Q000494:pharmacology*; D002466:Cell Nucleolus / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects*; D006801:Humans; D008042:Linolenic Acids / Q000494:pharmacology*; D008938:Mitosis / Q000187:drug effects*; D008940:Mitotic Index / Q000187:drug effects; D012516:Osteosarcoma / Q000473:pathology* / Q000648:ultrastructure; D014407:Tumor Cells, Cultured; D017965:gamma-Linolenic Acid
D000970:Antineoplastic Agents; D008042:Linolenic Acids; D017965:gamma-Linolenic Acid