title: The use of feline herpesvirus and baculovirus as vaccine vectors for the gag and env genes of feline leukaemia virus.
abstract: The env and gag genes from feline leukaemia virus were expressed in a thymidine kinase-negative feline herpes-virus and a baculovirus. Cats were vaccinated with various combinations of these recombinant viruses and 100% protection against feline leukaemia virus challenge was achieved using an immunization schedule which utilized both env and gag products delivered at both a mucosal and systemic site.
authors.affiliation: Animal Health Therapeutics Research, Upjohn Company, Kalamazoo, Michigan 49001-0199.
authors.forename: R C
authors.initials: RC
authors.lastname: Wardley
authors.forename: P J
authors.initials: PJ
authors.lastname: Berlinski
authors.forename: D R
authors.initials: DR
authors.lastname: Thomsen
authors.forename: A L
authors.initials: AL
authors.lastname: Meyer
authors.forename: L E
authors.initials: LE
authors.lastname: Post
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D016367:Baculoviridae / Q000235:genetics*; D002415:Cats; D015752:Genes, env; D015750:Genes, gag; D005822:Genetic Vectors; D006564:Herpesviridae / Q000235:genetics*; D005256:Leukemia Virus, Feline / Q000235:genetics / Q000276:immunology*; D011995:Recombination, Genetic; D015682:Retroviridae Proteins, Oncogenic / Q000008:administration & dosage / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D015682:Retroviridae Proteins, Oncogenic; D014765:Viral Vaccines; C045569:feline leukemia virus vaccine