title: In vitro activities of penciclovir and acyclovir against herpes simplex virus types 1 and 2.
abstract: Penciclovir (PCV) and acyclovir are acyclic guanine analogs which inhibit herpes simplex virus (HSV) DNA polymerase. Their 50% infective doses were 0.5 to 0.8 microgram/ml for clinical isolates of HSV-1 and 1.3 to 2.2 micrograms/ml for HSV-2. Furthermore, HSV-infected cultures receiving 2-h pulses of PCV had 2- to 50-fold less HSV than acyclovir-treated cultures, consistent with the prolonged intracellular half-life of PCV triphosphate.
authors.affiliation: Pediatric Infectious Diseases, University of Colorado School of Medicine, Denver 80262.
authors.forename: A
authors.initials: A
authors.lastname: Weinberg
authors.forename: B J
authors.initials: BJ
authors.lastname: Bate
authors.forename: H B
authors.initials: HB
authors.lastname: Masters
authors.forename: S A
authors.initials: SA
authors.lastname: Schneider
authors.forename: J C
authors.initials: JC
authors.lastname: Clark
authors.forename: C G
authors.initials: CG
authors.lastname: Wren
authors.forename: J A
authors.initials: JA
authors.lastname: Allaman
authors.forename: M J
authors.initials: MJ
authors.lastname: Levin
mesh_terms: D000212:Acyclovir / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D006147:Guanine; D006207:Half-Life; D006801:Humans; D018139:Simplexvirus / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; C053539:penciclovir; D006147:Guanine; D004259:DNA-Directed DNA Polymerase; D000212:Acyclovir