Hypertrophic cranial pachymeningitis due to Aspergillus flavus.
A 59-year-old woman suffered from occipital headache and bilateral cranial nerve VII, VIII, IX, X, XI and right XII deficit after developing otitis media. Magnetic resonance imaging (MRI) showed a thickening of the dura mater which was enhanced by gadolinium-DTPA (Gd). Aspergillus flavus was identified from the culture of otorrhea. She was treated with miconazole, flucytosin and fluconazole, which resulted in an improvement of the clinical symptoms and a thinning of the Gd-enhanced lesions on MRI. This is the first case of hypertrophic cranial pachymeningitis caused by Asp. flavus infection.
Murai
H
H
Department of Neurology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Kira
J
J
Kobayashi
T
T
Goto
I
I
Inoue
H
H
Hasuo
K
K
D001228:Aspergillosis / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D001231:Aspergillus flavus / Q000648:ultrastructure; D003131:Combined Modality Therapy; D004388:Dura Mater / Q000382:microbiology / Q000473:pathology*; D005260:Female; D006801:Humans; D006984:Hypertrophy; D008279:Magnetic Resonance Imaging; D015523:Maxillary Sinusitis / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D016921:Meningitis, Fungal / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D008825:Miconazole / Q000008:administration & dosage; D008875:Middle Aged; D009460:Neurologic Examination
D008825:Miconazole