Aplastic crisis due to human parvovirus B19 infection in hereditary hemolytic anaemia.
Specific anti-B19 IgM was demonstrated in sera from three children showing transient aplastic crisis. A two years-old boy living in Rio de Janeiro suffering from sickle-cell anaemia showed the crisis during August, 1990. Two siblings living in Santa Maria, RS, developed aplastic crisis during May, 1991, when they were also diagnosed for hereditary spherocytosis. For a third child from this same family, who first developed aplastic crisis no IgM anti-B19 was detected in her sera.
Cubel
R C
RC
Departamento de Virologia, Instituto Oswaldo Cruz, FIOCRUZ, RJ, Brasil.
Valadão
M C
MC
Pereira
W V
WV
Magalhães
M C
MC
Nascimento
J P
JP
D000741:Anemia, Aplastic / Q000175:diagnosis / Q000209:etiology*; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000175:diagnosis; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D016731:Erythema Infectiosum / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D016732:Parvovirus B19, Human / Q000276:immunology; D013103:Spherocytosis, Hereditary / Q000150:complications* / Q000175:diagnosis
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M