title: Systemic and local immune responses to enhanced-potency inactivated poliovirus vaccine in premature and term infants.
abstract: Serum neutralizing, nasopharyngeal neutralizing, and IgA antibodies to polioviruses 1, 2, and 3 were detected in preterm and term infants who had received three doses of an enhanced-potency inactivated poliovirus vaccine at 2, 4, and 12 months of age. After the third dose of this vaccine, 95% or more of the infants tested had detectable serum neutralizing antibodies to polioviruses types 1, 2, and 3. Nasopharyngeal neutralizing and IgA antibodies were detected in 43% to 91% of the infants. The peak geometric mean titers of serum and nasopharyngeal antibodies against polioviruses types 1, 2, and 3 were similar for both groups. These preliminary data indicate that preterm infants are capable of mounting systemic and local immune responses to enhanced-potency inactivated poliovirus vaccine that are comparable to those made by term infants.
authors.affiliation: Department of Pediatrics, Thomas Jefferson University, Philadelphia, Pennsylvania.
authors.forename: S C
authors.initials: SC
authors.lastname: Adenyi-Jones
authors.forename: H
authors.initials: H
authors.lastname: Faden
authors.forename: M B
authors.initials: MB
authors.lastname: Ferdon
authors.forename: M S
authors.initials: MS
authors.lastname: Kwong
authors.forename: P L
authors.initials: PL
authors.lastname: Ogra
mesh_terms: D000914:Antibodies, Viral / Q000276:immunology*; D000917:Antibody Formation / Q000276:immunology; D004341:Drug Evaluation; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D011051:Poliomyelitis / Q000276:immunology / Q000517:prevention & control*; D017955:Poliovirus / Q000276:immunology*; D011054:Poliovirus Vaccine, Inactivated / Q000276:immunology; D014611:Vaccination; D015164:Vaccines, Inactivated
chemical_list: D000914:Antibodies, Viral; D011054:Poliovirus Vaccine, Inactivated; D015164:Vaccines, Inactivated