Ceruloplasmin serum level in post-menopausal women treated with oral estrogens administered at different times.
The liver is an estrogen-responsive organ and the administration of estrogens in humans increases the hepatic synthesis of many proteins. The existence of a circadian rhythm of estrogen receptors in the liver has been proved by different authors. We studied the presence of a different responsiveness of the human liver to the estrogens in two groups of post-menopausal women by evaluating the changes in ceruloplasmin serum level. Conjugated equine estrogens were administered at different times (A: 8 a.m. and B: 8 p.m.). The replacement therapy increased ceruloplasmin serum levels both in group A and B, but the increase was higher in group B than in group A. These data reflect indirectly the presence of a circadian rhythm of hepatic responsiveness to the estrogens.
Clemente
C
C
Laboratorio di Biochimica, I.R.C.C.S.S. de Bellis Castellana G., Bari, Italy.
Russo
F
F
Caruso
M G
MG
Giangrande
M
M
Fanizza
G
G
Di Leo
A
A
D000328:Adult; D002570:Ceruloplasmin / Q000378:metabolism*; D002940:Circadian Rhythm; D004958:Estradiol / Q000097:blood; D015914:Estrogen Replacement Therapy; D004966:Estrogens, Conjugated (USP) / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008593:Menopause / Q000502:physiology*; D008875:Middle Aged
D004966:Estrogens, Conjugated (USP); D004958:Estradiol; D005640:Follicle Stimulating Hormone; D002570:Ceruloplasmin