Malignant rhabdoid tumour of the liver. A case report.
A case of primary malignant rhabdoid tumour of the liver occurring in a 5-month-old girl is reported. Histologically the neoplasm presented the 'typical' features as described in malignant rhabdoid tumour arising in the kidney. In addition, some areas of the tumour showed a 'pseudoglandular' growth pattern. Immunohistochemistry revealed the neoplastic cells to be intensively positive for vimentin and for cytokeratin 19. Variable immunoreactivity for cytokeratin polypeptides 7, 8 and 19 was also detected. On electronmicroscopy the neoplastic cells contained bundles of intermediate filaments, tonofilaments and intercellular junctions. These findings are suggestive of a primitive epithelial differentiation.
Foschini
M P
MP
Pathology Department II, UZ St Rafaël, Leuven, Belgium.
Van Eyken
P
P
Brock
P R
PR
Casteels-Van Daele
M
M
De Vos
R
R
Dal Cin
P
P
Van den Berghe
H
H
Desmet
V J
VJ
D015415:Biomarkers; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D008113:Liver Neoplasms / Q000737:chemistry* / Q000473:pathology* / Q000648:ultrastructure; D009396:Wilms Tumor / Q000737:chemistry* / Q000473:pathology* / Q000648:ultrastructure
D015415:Biomarkers