Conditional probability analysis for a domain model of Ca(2+)-inactivation of Ca2+ channels.
The domain model of Ca2+ inactivation of Ca2+ channels, which has been used to explain rapid inactivation of whole cell Ca2+ currents in pancreatic beta cells, is applied to single-time and conditional open probability measurements on guinea pig ventricular myocyte Ca2+ channels. These two measurements greatly constrain the choice of kinetic constants in the model. Calculations with the model provide a simple quantitative explanation of recent experimental results, including a slow increase in the inactivation rate.
Keizer
J
J
Institute of Theoretical Dynamics, University of California, Davis 95616.
Maki
L W
LW
D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D007515:Islets of Langerhans / Q000378:metabolism; D007700:Kinetics; D008954:Models, Biological; D011336:Probability; D013269:Stochastic Processes
D015220:Calcium Channels; D002118:Calcium