Comparative in vitro study of nonoxynol-9: effects on human, bull and boar spermatozoa.
Spermicidal activity of different dilutions of nonoxynol-9 (nonyl-phenoxy-polyethoxy-ethanol) on human, bull and boar spermatozoa was studied using the modified Sander-Cramer method. The results obtained showed that differences in spermatozoal resistance among the mentioned species to nonoxynol-9 were statistically very significant (P much less than 0.0005): bull greater than man greater than boar. The results obtained were compared to available literature results.
Arambasić
B M
BM
ICN-GALENIKA-Institute, Biology Laboratory, Beograd, Yugoslavia.
Subotin
M L
ML
Stanić
M
M
D000704:Analysis of Variance; D000818:Animals; D002417:Cattle; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008297:Male; D017137:Nonoxynol; D011092:Polyethylene Glycols / Q000494:pharmacology*; D013081:Sperm Motility / Q000187:drug effects; D013089:Spermatocidal Agents / Q000494:pharmacology*; D013094:Spermatozoa / Q000187:drug effects*; D013552:Swine
D013089:Spermatocidal Agents; D017137:Nonoxynol; D011092:Polyethylene Glycols