Intestinal-type alkaline phosphatase in urine as an indicator of mercury induced effects on the S3 segment of the proximal tubule.
Intestinal-type alkaline phosphatase (IAP) is a specific and sensitive marker for alterations of the S3 segment of the human proximal tubule, the preferred part for several nephrotoxins. We studied IAP and other renal parameters in mercury-exposed workers and their controls. IAP excretion is clearly increased in the exposed workers, compared to other parameters, indicating that the determination of this enzyme can be a useful screening test of renal effects in occupational mercury exposure.
Nuyts
G D
GD
University of Antwerp, Department of Nephrology-Hypertension, Antwerp, Belgium.
Roels
H A
HA
Verpooten
G F
GF
Bernard
A M
AM
Lauwerys
R R
RR
De Broe
M E
ME
D000118:Acetylglucosaminidase / Q000652:urine; D000328:Adult; D000469:Alkaline Phosphatase / Q000652:urine*; D006801:Humans; D007422:Intestines / Q000201:enzymology*; D007687:Kidney Tubules, Proximal / Q000187:drug effects*; D008297:Male; D008628:Mercury / Q000009:adverse effects*; D008875:Middle Aged
D000469:Alkaline Phosphatase; D000118:Acetylglucosaminidase; D008628:Mercury