title: Experimental in vivo generation of intertypic recombinant strains of HSV in the mouse.
abstract: The primary replication of one strain of HSV was generally unaffected by the simultaneous inoculation of another strain either at the same site or at a different site within the same dermatome. Exceptions to this were the result of the generation of intertypic recombinants which were readily isolated only from sensory ganglia 5 and 6 days after inoculation with a mixture of HSV-1 and HSV-2 and from explant culture of the resultant latently infected ganglia. By restriction enzyme analysis the majority of the recombinant strains from primary infection were characterized as HSV 1; all those from latently infected ganglia were characterized as type 2.
authors.affiliation: Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, U.K.
authors.forename: D L
authors.initials: DL
authors.lastname: Yirrell
authors.forename: C E
authors.initials: CE
authors.lastname: Rogers
authors.forename: W A
authors.initials: WA
authors.lastname: Blyth
authors.forename: T J
authors.initials: TJ
authors.lastname: Hill
mesh_terms: D000818:Animals; D005260:Female; D017245:Foscarnet; D005728:Ganglia, Sympathetic / Q000382:microbiology; D006561:Herpes Simplex / Q000382:microbiology; D051379:Mice; D008815:Mice, Inbred Strains; D010746:Phosphonoacetic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D011995:Recombination, Genetic; D018139:Simplexvirus / Q000187:drug effects / Q000235:genetics* / Q000502:physiology; D012867:Skin / Q000382:microbiology; D013045:Species Specificity; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects
chemical_list: D017245:Foscarnet; D010746:Phosphonoacetic Acid