Small cell lung carcinoma in a patient with Sotos syndrome: are genes at 3p21 involved in both conditions?
A 22 year old female with Sotos syndrome and a small cell lung carcinoma is described. This case is of interest not only because of the somatic growth pattern, atypical of Sotos syndrome, but also because of the association with a rare tumour. Of significance is the possible role of mutations at 3p21 in the aetiology of Sotos syndrome and tumour development.
Cole
T R
TR
Institute of Medical Genetics, University Hospital of Wales, Heath Park, Cardiff.
Hughes
H E
HE
Jeffreys
M J
MJ
Williams
G T
GT
Arnold
M M
MM
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000254:growth & development* / Q000473:pathology; D018288:Carcinoma, Small Cell / Q000150:complications* / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D002893:Chromosomes, Human, Pair 3; D005260:Female; D005877:Gigantism / Q000150:complications* / Q000235:genetics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008175:Lung Neoplasms / Q000150:complications* / Q000235:genetics; D013577:Syndrome