The laboratory and clinical safety evaluation of a dentifrice containing hydrogen peroxide and baking soda.
This study reports the laboratory, clinical, and microbiological finding of the safety testing and daily use of a dentifrice delivering 0.75% hydrogen peroxide and 5% baking soda. Laboratory studies using Ca45 labeled teeth and biologically stained teeth confirmed that the dentifrice did not decalcify enamel or bleach teeth. Over the course of a six-month period, 62 subjects using a hydrogen peroxide-baking soda dentifrice and 21 subjects using a control dentifrice were examined for oral soft tissue change and hard tissue alterations. No soft tissue changes attributable to the use of either dentifrice were noted. Experienced clinicians using Trubyte shade guide teeth observed no significant changes to the subjects' anterior teeth following 6 months use of the test dentifrice. Paired discrimination tests revealed that the examiners could distinguish color differences in the shade guide teeth at 0.7%. Microbiological monitoring of the subjects for six months use of their assigned dentifrice and for the following months on the control dentifrice, revealed neither an increased incidence of candida nor increased candida counts.
Fischman
S L
SL
SUNY at Buffalo, School of Dental Medicine.
Truelove
R B
RB
Hart
R
R
Cancro
L P
LP
D000328:Adult; D000368:Aged; D001639:Bicarbonates / Q000627:therapeutic use*; D003802:Dentifrices / Q000627:therapeutic use*; D005260:Female; D005884:Gingival Hemorrhage; D006801:Humans; D006861:Hydrogen Peroxide / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D012964:Sodium / Q000627:therapeutic use*; D017693:Sodium Bicarbonate; D014073:Tooth Bleaching; D017001:Tooth Demineralization
D001639:Bicarbonates; D003802:Dentifrices; D017693:Sodium Bicarbonate; D012964:Sodium; D006861:Hydrogen Peroxide