Kallikrein-kinin,enkephalin, renin-aldosterone and catecholamine systems in the vanadate (as vanadyl)-induced arterial hypertension.
Exposure to vanadate was found to induce arterial hypertension through effects on renin-angiotensin-aldosterone, renal peptidergic, and central and peripheral catecholaminergic systems. Vanadate increased, mainly in vascular myocells, both receptor-operated Ca2+ channel- and cyclic-AMP-dependent availability of Ca2+ for contractile processes. Vanadate was selectively accumulated by tissues in the +4 oxidation state (vanadyl).
Carmignani
M
M
Dept. of Cell Biology and Physiology, University of L'Aquila, Italy.
Preziosi
P
P
Del Carmine
R
R
Porcelli
G
G
Volpe
A R
AR
D000450:Aldosterone / Q000097:blood*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001920:Bradykinin / Q000494:pharmacology; D003994:Bucladesine / Q000494:pharmacology; D002395:Catecholamines / Q000378:metabolism; D003971:Diastole / Q000187:drug effects; D004745:Enkephalins / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects*; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D007545:Isoproterenol / Q000494:pharmacology; D007610:Kallikreins / Q000378:metabolism; D001121:Lysine Carboxypeptidase / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D015260:Neprilysin / Q000378:metabolism; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012083:Renin / Q000097:blood*; D013599:Systole / Q000187:drug effects; D013997:Time Factors; D014628:Vagotomy; D014638:Vanadates / Q000494:pharmacology*; D014702:Veratrine / Q000494:pharmacology
D002395:Catecholamines; D004745:Enkephalins; D014638:Vanadates; D000450:Aldosterone; D003994:Bucladesine; D007703:Peptidyl-Dipeptidase A; D001121:Lysine Carboxypeptidase; D007610:Kallikreins; D012083:Renin; D015260:Neprilysin; D014702:Veratrine; D007545:Isoproterenol; D001920:Bradykinin