title: In vivo binding of N1'-([11C]methyl)naltrindole to delta-opioid receptors in mouse brain.
abstract: The regional distribution of N1'-([11C]methyl)naltrindole ([11C]MeNTI) in vivo in mouse brain correlates with established delta opioid receptor densities in vitro. [11C]MeNTI binding is blocked by naltrindole, a delta antagonist, but not by cyprodime, a mu antagonist, of by (+/-)-U50,488, a kappa agonist. Thus, [11C]MeNTI selectively labels central delta opioid receptors in vivo in mouse, and shows promise for positron emission tomography studies of delta sites in human brain.
authors.affiliation: Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, MD 21205.
authors.forename: J R
authors.initials: JR
authors.lastname: Lever
authors.forename: U
authors.initials: U
authors.lastname: Scheffel
authors.forename: C M
authors.initials: CM
authors.lastname: Kinter
authors.forename: H T
authors.initials: HT
authors.lastname: Ravert
authors.forename: R F
authors.initials: RF
authors.lastname: Dannals
authors.forename: H N
authors.initials: HN
authors.lastname: Wagner
authors.forename: J J
authors.initials: JJ
authors.lastname: Frost
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002250:Carbon Radioisotopes; D007211:Indoles / Q000378:metabolism*; D008297:Male; D051379:Mice; D009019:Morphinans / Q000378:metabolism*; D011869:Radioligand Assay; D017465:Receptors, Opioid, delta / Q000187:drug effects / Q000378:metabolism*; D014055:Tomography, Emission-Computed
chemical_list: D002250:Carbon Radioisotopes; D007211:Indoles; D009019:Morphinans; D017465:Receptors, Opioid, delta; C074392:N-methylnaltrindole