[Effect of hydrochlorothiazide on various components of the kinin system and plasma renin activity in patients with arterial hypertension treated with captopril].
Combined hypertension treatment with inhibitors of the converting enzyme (ICE) and diuretocs gives manifold advantages, the most important of them is a synergistic action of both drugs resulting in blood pressure decrease and prevention of hypokaliaemia. The purpose of the present study was assessment of the effect of hydrochlorothiazide in 50 mg daily doses on blood levels of kininogen and prekallikrein and on plasma renin activity (PRA) in hypertensive patients treated during captopril 150 mg daily alone during 3 weeks, without success. The study was carried out on 15 patients with essential hypertension stage III after WHO. A control group comprised 18 healthy subjects. The determinations were done three time: before treatment, after 3 weeks on captopril, and after 2 weeks of combined treatment with captopril and hydrochlorothiazide. It was found combined treatment with captopril and hydrochlorothiazide produced blood pressure normalization in patients insufficiently responding to captopril alone. During the combined treatment normalization of blood pressure was associated with a higher fall of kininogen concentration, higher rise of prekallikrein and PRA in relation to the values obtained with captopril alone. This evidenced a more pronounced reaction of the kinin system and the renin-angiotensin-aldosterone system to the combined treatment as compared with the response of both systems to captopril alone.
Kolber-Postepska
B
B
Kliniki Kardiologii, Ak. Med., Lublinie.
Zebrowska-Lupina
I
I
Markiewicz
M
M
Horubała-Bielak
G
G
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D002216:Captopril / Q000008:administration & dosage*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage*; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D016234:Kallikrein-Kinin System / Q000187:drug effects* / Q000502:physiology; D007704:Kininogens / Q000037:antagonists & inhibitors / Q000097:blood; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D011288:Prekallikrein / Q000032:analysis; D012083:Renin / Q000097:blood*
D007704:Kininogens; D006852:Hydrochlorothiazide; D011288:Prekallikrein; D002216:Captopril; D007703:Peptidyl-Dipeptidase A; D012083:Renin
Wpływ hydrochlorotiazydu na niektóre składniki układu kinin oraz aktywność reninowa osocza u chorych na nadciśnienie tetnicze leczonych kaptoprylem.