A discrete mode of the antipyretic action of AVP, alpha-MSH and ACTH.
The antipyretic effect of AVP, alpha-MSH and ACTH consists in lowering the thermoregulatory threshold and in shortening the time span of the fever. Thus, neuropeptides influence activity of hypothalamic neurones regulating body temperature. This was confirmed by recent experiments of Moravec (this volume) which indicate that spontaneous activity and thermosensitivity of neurones in hypothalamic slices can be influenced, by AVP. Why neuropeptides of different chemical structure such as AVT, on one hand, and alpha-MSH and ACTH, on the other hand, induce the same effect on thermoregulation remains to be elucidated.
Ehymayed
H M
HM
Department of Comparative Physiology, Faculty of Science, Charles University, Prague.
Janský
L
L
D000324:Adrenocorticotropic Hormone / Q000502:physiology*; D000818:Animals; D001127:Arginine Vasopressin / Q000502:physiology*; D001833:Body Temperature Regulation / Q000502:physiology*; D005334:Fever / Q000503:physiopathology; D006801:Humans; D000521:alpha-MSH / Q000502:physiology*
D001127:Arginine Vasopressin; D000521:alpha-MSH; D000324:Adrenocorticotropic Hormone