Post-renal transplant diabetes mellitus--a retrospective study.
The prevalence of post-transplant diabetes mellitus in 222 consecutive live related renal allograft recipients over a 3-year period was found to be 11.7%. Most of them (20 of 26) developed diabetes mellitus within the first 4 months of transplantation. Post-transplant diabetic patients were older, and had a significantly greater incidence of avascular necrosis of bone. An assessment of risk factors showed that abnormal postprandial blood sugar pretransplant was a significant predictor for development of post-transplant diabetes, whereas cumulative oral steroid dose, weight gain after transplant, type of immunosuppression employed, and graft function were not important. We conclude that post-transplant diabetes mellitus frequently develops in patients with a predisposition by virtue of older age and pretransplant postprandial hyperglycaemia. While steroids are important in the pathogenesis, there was no demonstrable dose-response relationship; post-transplant diabetic patients may be a group with a greater propensity to steroid-induced complications.
Rao
M
M
Department of Nephrology, CMC Hospital, Vellore, India.
Jacob
C K
CK
Shastry
J C
JC
D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000328:Adult; D003920:Diabetes Mellitus / Q000209:etiology*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D010020:Osteonecrosis / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors
D000305:Adrenal Cortex Hormones