[Evaluation of the effectiveness of various methods of the treatment of tick-borne encephalitis in the acute period].
To reveal the dependence of the efficacy of the treatment of tick-borne encephalitis (TBE) on the patient's HLA phenotype and to elaborate recommendations for individual treatment, 98 subjects who suffered TBE and who received different types of therapy in the acute period (isolated or combined use of specific homologous immunoglobulin and RNase) were subjected to immunogenetic examinations. The clinical follow-up and immunological examination of the subjects indicated made it possible to distinguish groups with a favorable and unfavourable outcome due to the treatment carried out in the acute period. Computer processing of the immunogenetic data on the patients with TBE allowed the deriving of individual predictors of the efficacy of the symptomatic and etiotropic therapy of TBE. The final effect due to the application of agents possessing an immunomodulating effect on specific humoral immune response is determined not only by the gravity of viral infection but is also associated with a number of allele variants of HLA complex genes which the patient has.
Chernitsyna
L O
LO
Konenkov
V I
VI
Ierusalimskiĭ
A P
AP
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D004675:Encephalitis, Tick-Borne / Q000235:genetics / Q000628:therapy*; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D006801:Humans; D007116:Immunization, Passive / Q000379:methods*; D007075:Immunoglobulin M / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011379:Prognosis; D012260:Ribonucleases / Q000008:administration & dosage*; D012737:Sex Factors
D005819:Genetic Markers; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D007075:Immunoglobulin M; D012260:Ribonucleases
Otsenka éffektivnosti primeneniia razlichnykh metodov lecheniia kleshchevogo éntsefalita v ostrom periode.