Hemagglutination by a human rotavirus isolate as evidence for transmission of animal rotaviruses to humans.
Human rotavirus strain Ro1845, which was isolated in 1985 from an Israeli child with diarrhea, has a hemagglutinin that is capable of agglutinating erythrocytes from guinea pigs, sheep, chickens, and humans (group O). Hemagglutination was inhibited after incubation with hyperimmune sera or in the presence of glycophorin, the erythrocyte receptor for animal rotaviruses. These results suggest that Ro1845 is an animal rotavirus that infected a human child.
Nakagomi
O
O
Department of Laboratory Medicine, Akita University School of Medicine, Japan.
Mochizuki
M
M
Aboudy
Y
Y
Shif
I
I
Silberstein
I
I
Nakagomi
T
T
D000818:Animals; D006384:Hemagglutination; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D066298:In Vitro Techniques; D012401:Rotavirus / Q000145:classification / Q000276:immunology* / Q000472:pathogenicity; D012400:Rotavirus Infections / Q000635:transmission*; D013045:Species Specificity