[Circadian changes of atrial natriuretic peptide, cyclic AMP, cyclic GMP, sodium, blood pressure and heart rate in normal subjects].
To investigate the circadian change in the plasma atrial natriuretic peptide (ANP) concentrations and its relation to cyclic AMP (cAMP), cyclic GMP (cGMP) and serum sodium. This investigation was conducted on 22 normal subjects consisting of 16 men and 6 women with a mean age of 21.5 years. Blood samples, systolic blood pressure (SBP), and heart rate (HR), were collected and recorded every 8 hours during a 24 hour period. SBP and HR were highest at 1600 h (p less than 0.05). Plasma ANP concentrations at 0800 h (196.3 +/- 140.6 ng/L, p less than 0.01) and 1600 h (203.4 +/- 127.5 ng/L, p less than 0.01) were higher than at 2400 h (64.4 +/- 46.0 ng/L). Serum sodium, plasma cAMP, and cGMP were at the highest level at 1600 h (p less than 0.05). Plasma ANP correlated with plasma cAMP, cGMP, serum sodium, SBP, and HR (r = 0.378 - 0.419, p less than 0.05). This data supports the assumption that atrial wall distension seems to be a stimulus for ANP release.
Xu
C T
CT
Department of Gastroenterology, Air Force Hospital, Lanzhou.
Wang
Y M
YM
D000293:Adolescent; D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001794:Blood Pressure; D002940:Circadian Rhythm; D000242:Cyclic AMP / Q000097:blood*; D006152:Cyclic GMP / Q000097:blood*; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D012964:Sodium / Q000097:blood*
D009320:Atrial Natriuretic Factor; D012964:Sodium; D000242:Cyclic AMP; D006152:Cyclic GMP