[Adrenergic control of myocardial contractile function in rats with incorporated 137Cs].
It was shown on isolated myocardium preparations that internal gamma irradiation of rats with 137Cs (1.6 MBq/kg) decreased the contractile function of ventricles and had no essential effect on the auricle contractility. The inotropic response of myocardium to activation of alpha-adrenergic receptors decreased, and of beta-adrenergic receptors decreased.
Shilov
V V
VV
Lobanok
L M
LM
D000818:Animals; D002588:Cesium Radioisotopes / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects*; D010656:Phenylephrine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011833:Radiation Injuries, Experimental / Q000503:physiopathology*; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects*; D013997:Time Factors
D002588:Cesium Radioisotopes; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D010656:Phenylephrine; D011433:Propranolol; D007545:Isoproterenol
Adrenergicheskiĭ kontrol' sokratitel'noĭ funktsii miokarda krys s inkorporirovannym 137Cs.