[Changes in cellular ion transport and arterial pressure in renal transplant recipients undergoing cyclosporin treatment].
Arterial hypertension is a common side effect of cyclosporine A (CyA). Aim of the study was to evaluate the activity of erythrocyte (RBC) Na transport in two groups of patients with a well functioning renal graft (Crs less than 1.7 mg/dl) treated by prednisone+azathioprine (10 pts), or prednisone+CyA (21 pts), in relationship with blood pressure status. Twenty-one age matched healthy subjects were studied as a control group. Na,K pump and Na,K cotransport were significantly lower in CyA than in AZA patients (2,184 +/- 106 vs 3,089 +/- 162 and 58 +/- 8 vs 187 +/- 28 mumol/l RBC/h: p less than 0.01), without differences between normotensive and hypertensive patients. Na,K pump efflux in normal subjects was 2334 +/- 66 mumol/l RBC/h (p less than 0.01 vs AZA), NA,K cotransport was 205 +/- 18 mumol/l RBC/h (p less than 0.01 vs CyA). Significant correlations were found between RBC Na,K pump activity and trough plasma CyA levels (p less than 0.02) and between systolic pressure and plasma creatinine in CyA patients (p less than 0.01). Trough plasma CyA levels were higher in hypertensive than in normotensive CyA patients (64 +/- 5 vs 46 +/- 4 ng/ml; p less than 0.01).
Borca
M
M
Istituto di Nefro-Urologia, Università di Torino.
Guarena
C
C
Boero
R
R
Basolo
B
B
Maffei
S
S
Forneris
G
G
Iadarola
G M
GM
Stramignoni
E
E
Quarello
F
F
D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D016572:Cyclosporine / Q000009:adverse effects* / Q000097:blood / Q000494:pharmacology; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000139:chemically induced*; D016030:Kidney Transplantation; D008297:Male; D011183:Postoperative Complications / Q000139:chemically induced*; D011241:Prednisone / Q000627:therapeutic use; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood / Q000187:drug effects*
D016572:Cyclosporine; D000254:Sodium-Potassium-Exchanging ATPase; D001379:Azathioprine; D011241:Prednisone
Alterazioni del trasporto ionico cellulare e pressione arteriosa nei portatori di trapianto renale in trattamento con ciclosporina.