[Effects of 1,25-(OH)2D3 on the secretion of growth hormone by human pituitary growth hormone-secreting tumors in vitro].
This work studied the effects of 1,25-(OH)2D3 on the secretion of growth hormone (GH) in 15 cases of human pituitary GH-secreting tumor cell cultures. At physiological doses (40-80 pg/ml) of 1,25-(OH)2D3, a GH secretion response was found in 14 cases of pituitary tumor: GH secretion was suppressed significantly in 9 of 14 cases and was markedly stimulated in only 2 of 14 cases of pituitary tumors. In the other 3 cases, the GH response was variable at different days of culture. The degree of suppression of GH secretion induced by 1,25-(OH)2D3 in all cases was 63.1 +/- 3.3% (means +/- sx of the control, and the average increase of GH secretion was 164.0 +/- 6.2% of control. There was no correlation between the type of GH reaction and the dose rang of 1,25-(OH)2D3 used in the experiment. The stimulatory effect on GH secretion did not appear after 2 weeks of culture. The results demonstrate that 1,25-(OH)2D3 at physiological doses has a direct regulatory effect (mainly suppressive) on GH secretion in most pituitary GH-secreting tumors in cell culture.
Deng
J
J
PUMC Hospital, Beijing.
D000239:Adenoma, Acidophil / Q000378:metabolism* / Q000473:pathology; D002117:Calcitriol / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D010911:Pituitary Neoplasms / Q000378:metabolism* / Q000473:pathology; D014407:Tumor Cells, Cultured
D013006:Growth Hormone; D002117:Calcitriol