Infection by polyomavirus of murine cells deficient in class I major histocompatibility complex expression.
Embryonic fibroblasts and kidney epithelial cells from beta 2-microglobulin-deficient mice were as infectible by polyomavirus as cells from normal littermates were, as judged by expression of nuclear viral capsid antigen, development of cytopathic effects, and yields of infectious virus. We conclude that expression of intact class I major histocompatibility complex molecules is not essential for polyomavirus infection.
Sanjuan
N
N
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115.
Zijlstra
M
M
Carroll
J
J
Jaenisch
R
R
Benjamin
T
T
D000818:Animals; D002478:Cells, Cultured; D015870:Gene Expression; D005805:Genes, MHC Class I; D007124:Immunoenzyme Techniques; D051379:Mice; D011120:Polyomavirus / Q000235:genetics / Q000502:physiology*; D014779:Virus Replication