Molecular cloning and characterization of a mouse alpha 2C2 adrenoceptor subtype gene.
A clone MA2C2 encoding the murine homologue of adrenoceptor alpha 2C2 was isolated from a mouse genomic library using a subtype specific probe. The nucleotide and the deduced amino acid sequences derived from an ApaI fragment (2 kb) of the clone reveal a single open reading frame encoding a putative receptor protein of 455 amino acids. The 5' untranslated region (0.5 kb) sequenced is characterized by high GC content and CpG island count.
Chen
W M
WM
Institute of Microbiology and Immunology, Neuroscience and Clinical Medicine, National Yang-Ming Medical College, Taipei, Taiwan, ROC.
Chang
A C
AC
Shie
B J
BJ
Chang
Y H
YH
Chang
N C
NC
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular / Q000379:methods; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides; D016376:Oligonucleotides, Antisense; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000145:classification / Q000235:genetics*; D012045:Regulatory Sequences, Nucleic Acid; D015183:Restriction Mapping; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid
D009838:Oligodeoxyribonucleotides; D016376:Oligonucleotides, Antisense; D011942:Receptors, Adrenergic, alpha