Multiple histamine receptors: properties and functional characteristics.
Recent advances in molecular biological techniques have seen the cloning of the H2-receptor gene from canine parietal cells, and the structural identification and cloning of the H1- and H3-receptors should soon follow. This information will allow the elucidation of the mechanisms responsible for the species and tissue heterogeneity in the H1-receptor binding and functional characteristics. The mechanisms underlying the inhibitory effect of H3-receptor stimulation on neurotransmitter release remains to be established, but this receptor appears to be coupled to its effector system (perhaps an ion channel?) via a G-protein. Patch-clamp studies on histamine receptors in invertebrate neurones have identified a ligand-gated chloride channel at a photoreceptor synapse of the housefly and it remains an intriguing possibility that there is a counterpart in mammalian species.
Hill
S J
SJ
Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham, U.K.
D000818:Animals; D006632:Histamine / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology; D007700:Kinetics; D011968:Receptors, Histamine / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D011969:Receptors, Histamine H1 / Q000378:metabolism / Q000502:physiology; D011970:Receptors, Histamine H2 / Q000378:metabolism / Q000502:physiology; D018100:Receptors, Histamine H3; D015398:Signal Transduction
D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D018100:Receptors, Histamine H3; D006632:Histamine