Tcrb-V3+ T-cell deletion and a mouse mammary tumor provirus, Mtv-27.
Genes encoding superantigens which delete Tcrb-V3+ T cells co-segregate with mouse mammary tumor proviruses (Mtv), Mtv-1, Mtv-3, Mtv-6, Mtv-13, and Mtv-44. We have examined percentages of Tcrb-V3+ T cells and Mtv integrations in [(B10 x NZB)F1 x B10.BR] mice, and show that Mtv-27 as well as Mtv-3 from NZB mice co-segregate with genes encoding deletion ligands for Tcrb-V3+ T cells without recombination.
Tomonari
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K
Transplantation Biology Section, MRC Clinical Research Centre, Harrow, UK.
Fairchild
S
S
Rosenwasser
O A
OA
D000818:Animals; D015139:Blotting, Southern; D016679:Genome, Viral; D008212:Lymphocyte Depletion; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics*; D051379:Mice; D008810:Mice, Inbred C57BL; D008814:Mice, Inbred NZB; D011533:Proviruses / Q000235:genetics*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000032:analysis*; D013601:T-Lymphocytes / Q000276:immunology*
D016693:Receptors, Antigen, T-Cell, alpha-beta