title: Doppler assessment of the uterine circulation and the clinical behaviour of gestational trophoblastic tumours requiring chemotherapy.
abstract: The haemodynamics of the uterine arteries and myometrium were assessed using Doppler ultrasound in forty consecutive patients requiring treatment for invasive mole and choriocarcinoma. The investigations were performed prior to the commencement of chemotherapy and the subjects followed prospectively. The Doppler waveforms from the uterine arteries were analysed using the pulsatility index. It was found that patients with a pulsatility index of 1.1 or less were significantly more likely to develop drug resistance than those with a higher value (P < 0.04). There was no significant association between the pulsatility index and metastatic disease or uterine bleeding. Five out of eight patients who developed drug resistance could have avoided initial inadequate treatment if the Doppler findings were included in the scoring system for selecting chemotherapy for these tumours. It can be concluded that assessment of the uterine arteries using the pulsatility index prior to the treatment of patients with invasive mole and choriocarcinoma is of help in predicting those who will develop drug resistance.
authors.affiliation: Department of Medical Oncology, Charing Cross Hospital, London, UK.
authors.forename: M G
authors.initials: MG
authors.lastname: Long
authors.forename: J E
authors.initials: JE
authors.lastname: Boultbee
authors.forename: R
authors.initials: R
authors.lastname: Langley
authors.forename: E S
authors.initials: ES
authors.lastname: Newlands
authors.forename: R H
authors.initials: RH
authors.lastname: Begent
authors.forename: K D
authors.initials: KD
authors.lastname: Bagshawe
mesh_terms: D001158:Arteries / Q000000981:diagnostic imaging; D002822:Choriocarcinoma / Q000098:blood supply / Q000000981:diagnostic imaging / Q000188:drug therapy; D006063:Chorionic Gonadotropin / Q000032:analysis; D004351:Drug Resistance; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000098:blood supply / Q000000981:diagnostic imaging / Q000188:drug therapy; D009215:Myometrium / Q000098:blood supply / Q000000981:diagnostic imaging; D011247:Pregnancy; D011446:Prospective Studies; D012039:Regional Blood Flow / Q000502:physiology; D014328:Trophoblastic Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000188:drug therapy; D014465:Ultrasonics; D014463:Ultrasonography; D014594:Uterine Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000188:drug therapy; D014599:Uterus / Q000098:blood supply* / Q000000981:diagnostic imaging
chemical_list: D006063:Chorionic Gonadotropin