[The effect of lipid emulsions on the mechanisms of organic defense in infectious injury].
For treatment of metabolic derangements in infective states intravenous lipidic emulsions have been used. Their use is however not harmless existing reports on fat inhibiting the function of blood polymorphonuclear leukocytes and macrophages. The purpose of the research reported herewith was to study in rats the effect of new intravenous lipidic emulsions containing medium chain triglycerides and long chain triglycerides and compare it with the effect of long chain triglycerides emulsion on function of polymorphonuclear leukocytes (chemotaxis, phagocytosis and bactericidal activity). The intraperitoneal implant of an E. coli capsule was used for the study. The transfusions of both lipidic emulsions in septic rats have not altered functions of polymorphonuclear leukocytes when compared with saline infusion. However there was found hepatic steatosis, hypertrophy and presence of fat globules in the Kupffer cells in rats infused with medium chain and long chain triglyceride emulsions. Sequential blood cultures obtained from rats infused with the emulsions showed increased bacterial growth with medium chain triglyceride emulsion. There was no significant difference between the rats that received both lipid infusions and those that received saline infusions as to the mortality. Our experimental study suggests that the use of fat emulsions in infective states be done with care and monitoring of seric triglycerides and steroids.
Waitzberg
D L
DL
Departamento de Cirurgia, Faculdade de Medicina, Universidade de São Paulo.
Yamaguchi
N
N
Bellinati-Pires
R
R
Leone
M C
MC
Masili-Oku
S M
SM
Salgado
M M
MM
Soares
S R
SR
Lima-Gonçalves
E
E
D000704:Analysis of Variance; D000818:Animals; D001770:Blood Bactericidal Activity / Q000187:drug effects / Q000276:immunology; D016009:Chi-Square Distribution; D004195:Disease Models, Animal; D004927:Escherichia coli Infections / Q000276:immunology / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D005217:Fat Emulsions, Intravenous / Q000494:pharmacology*; D008297:Male; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D005217:Fat Emulsions, Intravenous
Efeito de emulsões lipídicas sobre mecanismos de defesa orgânica na agressão infecciosa.