[The effect of activation of the superior colliculus on the convulsive activity during picrotoxin-induced kindling].
Bilateral administration of picrotoxin, bicucullin or benzilpenicillin to the colliculi superior induced high-amplitude hypersynchronous discharges in rats. In these conditions, a suppression of generalized seizures induced with picrotoxin, was observed. The superior colliculi seem to play a significant part in antiepileptic system, the part being realized through generator mechanism.
Shandra
A A
AA
Godlevskiĭ
L S
LS
Vikhrestiuk
S L
SL
Oleĭnik
A A
AA
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D004569:Electroencephalography / Q000187:drug effects; D007696:Kindling, Neurologic / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008845:Microinjections; D010400:Penicillin G / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*; D013477:Superior Colliculi / Q000187:drug effects* / Q000502:physiology
D001640:Bicuculline; D010400:Penicillin G; D010852:Picrotoxin
Vliianie aktivatsii verkhnikh bugorkov chetverokholmiia na sudorozhnuiu aktivnost' pri pikrotoksinovom kindlinge.