Effect of oatbran on mild hyperlipidaemia.
OBJECTIVE
To determine whether adding 60 g oatbran per day to a low saturated fat, low cholesterol diet has any additional effect of lowering serum lipids.


METHODS
A double blind, prospective, randomised, placebo controlled crossover study.


METHODS
Lipid clinic in a teaching hospital.


METHODS
Thirty-seven subjects (16 men, 21 women) with serum cholesterol of 5.5-8.0 mmol/L were recruited from staff and medical clinics. All subjects were aware of their hyperlipidaemia and no subject was previously treated with lipid lowering agents.


METHODS
After an eight-week diet period subjects were randomised to receive two muffins per day containing either 60 g of oatbran or the equivalent amount of fibre from wheatbran in a double blind crossover study.


METHODS
Measurement of lipids, lipoproteins and biochemical parameters at the end of each eight-week period.


RESULTS
Mean serum lipid levels at the end of the oatbran and wheatbran periods were significantly different from each other only for low density lipoprotein (LDL) cholesterol (oatbran, 4.67 mmol/L; SD, 0.85; and wheatbran, 4.95 mmol/L; SD, 0.81; P < 0.01), the LDL/HDL (high density lipoprotein) ratio (oatbran, 3.68; SD, 1.25; and wheatbran, 4.01; SD, 1.25; P < 0.001) and apoprotein B (oatbran, 1.03 g/L; SD, 0.21; and wheatbran, 1.08 g/L; SD, 0.19; P < 0.05).


CONCLUSIONS
Oatbran fibre is more effective than wheatbran fibre in lowering cholesterol in subjects with mild hyperlipidaemia who are already on a low saturated fat, low cholesterol diet.
Lepre
F
F
Princess Alexandra Hospital, Woolloongabba, Qld.
Crane
S
S
D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000097:blood; D004043:Dietary Fiber / Q000627:therapeutic use*; D004311:Double-Blind Method; D002523:Edible Grain; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000178:diet therapy*; D008074:Lipoproteins / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014280:Triglycerides / Q000097:blood; D014908:Triticum
D004043:Dietary Fiber; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002784:Cholesterol