title: Sonographic evaluation of gallbladder motility in patients with end-stage renal disease on haemodialysis.
abstract: Thirty nine patients with end-stage renal disease on haemodialysis therapy with upper gastrointestinal symptoms were investigated for gallbladder motor function as the cause of their symptoms using cholecystosonography in fasting state, after a cholecystokinetic agent (BILOPTIN fatty meal) and after a smooth muscle relaxant (BUSCOPAN). Forty healthy individuals served as a control group. No significant difference was found between dialysis patients and healthy controls regarding the gallbladder area during fasting state, or the variation in the area of gallbladder during maximal contraction and dilatation. However, the patients on dialysis therapy of longer duration had stronger gallbladder contraction in response to a cholecystokinetic agent. Serum gastrin concentrations were increased in haemodialysis patients, but there was no consistent relationship between serum gastrin and gallbladder motility. The upper gastrointestinal symptoms of dialysis patients are unlikely to be due to disturbed gallbladder motility.
authors.affiliation: Department of Internal Medicine II, Technical University of Aachen, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Gladziwa
authors.forename: S
authors.initials: S
authors.lastname: Wagner
authors.forename: R
authors.initials: R
authors.lastname: Kock
authors.forename: H
authors.initials: H
authors.lastname: Mann
authors.forename: H G
authors.initials: HG
authors.lastname: Sieberth
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005755:Gastrins / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction; D006435:Renal Dialysis; D014463:Ultrasonography
chemical_list: D005755:Gastrins