title: Alpha-adrenoceptors involved on the cardiovascular response induced by mianserin in the pithed rat.
abstract: 1. The effects of the antidepressant drug mianserin on the cardiovascular responses induced by preganglionic electrical stimulation, and i.v. infusion of the adrenergic agonists noradrenaline (NA, alpha 1 and alpha 2), phenylephrine (alpha 1) and xylazine (alpha 2) in the pithed normotensive rat were studied. 2. Mianserin inhibited in a dose-dependent manner the pressor effect caused by electrical stimulation of spinal cord (Th7-Th9) and the infusion of NA, phenylephrine and xylazine. Cocaine increased the inhibitory effect of mianserin on the pressor effect caused by electrical stimulation and NA. 3. Mianserin blocked the xylazine-induced inhibition of cardiac nerve stimulation effect. 4. These results suggest that mianserin blocks the NA uptake, and it is more effective in blocking presynaptic alpha 2- than postsynaptic alpha-adrenoceptors.
authors.affiliation: Departamento de Farmacología, Facultad de Medicina, Universidad de Valladolid, Madrid, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: García-Roldán
authors.forename: J
authors.initials: J
authors.lastname: Torres
authors.forename: J
authors.initials: J
authors.lastname: Marín
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003655:Decerebrate State; D004558:Electric Stimulation; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D008803:Mianserin / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology*; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology; D013564:Sympathetic Nervous System / Q000187:drug effects; D014991:Xylazine / Q000494:pharmacology
chemical_list: D011942:Receptors, Adrenergic, alpha; D010656:Phenylephrine; D008803:Mianserin; D014991:Xylazine; D009638:Norepinephrine