title: D-penicillamine therapy associated with rapidly progressive glomerulonephritis.
abstract: A 55-year-old woman with advanced rheumatoid arthritis developed rapidly progressive glomerulonephritis with epithelial crescents and pulmonary hemorrhage following treatment with D-penicillamine. D-penicillamine was then withdrawn and a pulse therapy with methylprednisolone halted the progression of kidney and lung damage. We review the other cases previously reported and discuss pathogenesis and treatment of this rare condition.
authors.affiliation: Rheumatology Unit, Hospital Virgen de la Salud, Toledo, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Macarrón
authors.forename: J E
authors.initials: JE
authors.lastname: García Díaz
authors.forename: J A
authors.initials: JA
authors.lastname: Azofra
authors.forename: J
authors.initials: J
authors.lastname: Martín de Francisco
authors.forename: E
authors.initials: E
authors.lastname: Gonzalez
authors.forename: G
authors.initials: G
authors.lastname: Fernandez
authors.forename: J
authors.initials: J
authors.lastname: Sampedro
mesh_terms: D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D005260:Female; D005921:Glomerulonephritis / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D006469:Hemoptysis / Q000139:chemically induced; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D010396:Penicillamine / Q000009:adverse effects*
chemical_list: D010396:Penicillamine; D008775:Methylprednisolone