title: Effects of phenobarbital, carbamazepine and a combination of both on corazol-induced changes in the bioelectric activity of rat brains.
abstract: Combined forms of epileptic seizures are known to require combinations of antiepileptic drugs for their management. This study investigated the effects of such a combination consisting of phenobarbital and carbamazepine (mixed in the 1:4 ratio) as well as the effects of each component used separately on the Corazol-induced bioelectrical brain discharges. The effects were studied in a group of rats that received only a single dose of the drugs, as well as in a group that underwent 14-day anticonvulsant treatments. The bioelectric activity of the brain was recorded using an EEG method. In a single dosage, the combination of phenobarbital and carbamazepine was found to be more effective than its components. The decrease of Corazol-induced discharges was more pronounced in a single administration of the combination than when it was applied repeatedly. Development of a cumulative effect was observed in respect to carbamazepine action on the Corazol-induced discharges.
authors.affiliation: University of Medicine, Department of Pharmacology and Medicinal Toxicology, Plovdiv, Bulgaria.
authors.forename: I
authors.initials: I
authors.lastname: Kostadinova
authors.forename: M
authors.initials: M
authors.lastname: Millusheva
authors.forename: A
authors.initials: A
authors.lastname: Krustev
authors.forename: D
authors.initials: D
authors.lastname: Toreva
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology; D002220:Carbamazepine / Q000008:administration & dosage*; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D010433:Pentylenetetrazole / Q000633:toxicity; D010634:Phenobarbital / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002220:Carbamazepine; D010433:Pentylenetetrazole; D010634:Phenobarbital