title: Solid-phase synthesis of an RNA nucleopeptide fragment from the nucleoprotein of poliovirus.
abstract: The naturally occurring RNA-nucleopeptide H-Ala-Tyr[5'-pUUAAAAC-3']-NH2 is prepared via a solid-phase phosphite triester approach using N-SiOMB/O-TBDMS-protected nucleosides. Preliminary 1H-NMR studies show that the peptidyl unit has a remarkable effect on the conformational behaviour of the RNA moiety in the nucleopeptide.
authors.affiliation: Gorlaeus Laboratory, Leiden, The Netherlands.
authors.forename: C M
authors.initials: CM
authors.lastname: Dreef-Tromp
authors.forename: H
authors.initials: H
authors.lastname: van den Elst
authors.forename: J E
authors.initials: JE
authors.lastname: van den Boogaart
authors.forename: G A
authors.initials: GA
authors.lastname: van der Marel
authors.forename: J H
authors.initials: JH
authors.lastname: van Boom
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D009690:Nucleic Acid Conformation; D009698:Nucleoproteins / Q000737:chemistry; D009843:Oligoribonucleotides / Q000737:chemistry*; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000737:chemistry; D017955:Poliovirus / Q000737:chemistry*; D012367:RNA, Viral / Q000737:chemistry*; D012261:Ribonucleoproteins / Q000138:chemical synthesis* / Q000737:chemistry; D014764:Viral Proteins / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009698:Nucleoproteins; D009843:Oligoribonucleotides; D010446:Peptide Fragments; D012367:RNA, Viral; D012261:Ribonucleoproteins; D014764:Viral Proteins