Acute effect of manidipine on renal blood flow measured by pulsed-Doppler flowmeter in normal subjects.
The purpose of this study was to examine the effect of manidipine hydrochloride, a new calcium antagonist, on renal blood flow in healthy subjects, using the newly developed pulsed-Doppler flowmeter with colored flow imager and digital computer analyzer. Results in previous studies differed because the para-aminohippurate clearance method measures the average not real-time value. Sixteen healthy volunteers (n = 7, manidipine 20 mg; n = 9, placebo control) participated in the study. Before and 1 h after drug administration, pulsed-Doppler measurements were carried out by transabdominal approach with patients in the supine position. Manidipine hydrochloride increased renal blood flow significantly compared with placebo (13.8 +/- 4.7% vs. 6.1 +/- 5.6%; p < 0.05). There was a significant (p < 0.005) between group difference in the reduction in systolic blood pressure (-14.8 +/- 1.6 mmHg manidipine; -3.0 +/- 2.1 mmHg placebo). These data suggest that manidipine hydrochloride has a vasodilating effect on renal arterioles and a beneficial effect on the kidneys of hypertensive patients. Further, the pulsed-Doppler flowmeter may become a very useful tool for noninvasive measurement of renal blood flow.
Kasai
Y
Y
Department of Internal Medicine, Miyagi National Hospital, Japan.
Sheu
H L
HL
Yabe
T
T
Saso
S
S
Abe
K
K
D000328:Adult; D015924:Blood Pressure Monitors; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004095:Dihydropyridines / Q000494:pharmacology*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009578:Nitrobenzenes; D010879:Piperazines; D012077:Renal Artery / Q000000981:diagnostic imaging / Q000187:drug effects / Q000502:physiology; D012079:Renal Circulation / Q000187:drug effects*; D014463:Ultrasonography / Q000295:instrumentation
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D009578:Nitrobenzenes; D010879:Piperazines; C054218:manidipine