[Effect of experimental diabetes and thyrotropic hormone on carbohydrate and lipid metabolism in heart and liver of rats].
The purpose of this research was to analyse the change in relationships between the carbohydrate and lipid metabolism parameters in the cardiac muscle and liver in the rats, in which the thyroid gland was induced additionally by use of thyrotropic hormone. The tests were performed on 33 white rats of the Wistar breed that were subdivided into four groups. The first group were reference animals. In the rats of the second group thyroid hyperfunction was induced by use of thyrotropic hormone. In animals of group there diabetes was evoked by use of alloxan. Diabetes and the thyroid hyperfunction the animals in of group four. The levels of glycogen, lactic and pyruvic acids, cholesterol, free fatty acids, phospholipids and triglycerides were determined in the cardiac muscle and liver of all the animals. It was found that the occurrence of both hormonal disorders: experimental diabetes and thyroid hyperfunction noticeably changes metabolism of the cardiac muscle as well as the carbohydrate and lipid metabolism and leads to disorders of carbohydrate metabolism in the liver.
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Miedzywydziałowej Katedry Patofizjologii, Akademii Medycznej im. M. Kopernika, Krakowie.
D000818:Animals; D050260:Carbohydrate Metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005260:Female; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013972:Thyrotropin / Q000494:pharmacology*
D013972:Thyrotropin
Wpływ cukrzycy doświadczalnej i hormonu tyreotropowego na metabolizm weglowodanów i lipidów w mieśniu sercowym i watrobie szczurów.