Hepatocellular carcinoma and sex hormones.
The liver is morphologically and functionally modulated by sex hormones. Long-term use of oral contraceptives and androgenic steroids can induce benign and malignant hepatocellular tumors. Hepatocellular carcinoma (HCC) is more prevalent in men than in women. The role of sex hormones and their receptors in the development of HCC was reviewed. Some HCCs may be androgen dependent but others may be estrogen or even both dependent. Further studies are mandatory in order to utilize such characteristics of HCC for an effective prophylaxis and therapy of this tumor.
Nagasue
N
N
Second Department of Surgery, Shimane Medical University, Izumo, Japan.
Kohno
H
H
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced* / Q000737:chemistry / Q000188:drug therapy; D005260:Female; D012739:Gonadal Steroid Hormones / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000737:chemistry / Q000188:drug therapy; D008297:Male; D011956:Receptors, Cell Surface / Q000032:analysis
D012739:Gonadal Steroid Hormones; D011956:Receptors, Cell Surface