Agrin and the organization of the neuromuscular junction.
Agrin is a component of the synaptic extracellular matrix and may regulate the organization of acetylcholine receptors and other synaptic molecules in both synapse regeneration and development. Analyses of cDNAs encoding agrin define a number of structural domains, including regions of homology to laminin, Kazal protease inhibitors, and epidermal growth factor repeats.
Rupp
F
F
Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Beckman Center, Stanford University, California 94305.
Hoch
W
W
Campanelli
J T
JT
Kreiner
T
T
Scheller
R H
RH
D018171:Agrin; D000818:Animals; D005109:Extracellular Matrix / Q000502:physiology; D006801:Humans; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009469:Neuromuscular Junction / Q000502:physiology* / Q000648:ultrastructure; D011950:Receptors, Cholinergic / Q000502:physiology
D018171:Agrin; D009419:Nerve Tissue Proteins; D011950:Receptors, Cholinergic