[Disseminated sclerosis and retrovirus].
Multiple sclerosis is a disease characterized by neurologic dysfunction due to focal CNS lesions with demyelination. The cause of the disease is unknown; but it may be due to a virus and/or autoimmune reactions. The latter cause is suspected on account of family- and ethnical studies, the first on account of locally produced antibodies in the cerebrospinal fluid, and also epidemiologic investigations. The newly discovered human retroviruses, especially HTLV-I which is the cause of tropical spastic paraparesis, has been suspected as a possible cause; but this has been disproved by multiple antibody- and PCR-studies. An uncharacterized exogenous or an endogenous retrovirus is still considered to be a possible cause or possibly partial cause of the disease which could be multifactorial.
Møller-Larsen
A
A
Institute for Medicinsk Mikrobiologi, Aarhus Universitet.
Sommerlund
M
M
Haahr
S
S
D001327:Autoimmune Diseases; D015490:HTLV-I Infections / Q000150:complications / Q000276:immunology; D006801:Humans; D009103:Multiple Sclerosis / Q000209:etiology / Q000276:immunology / Q000382:microbiology*; D015493:Paraparesis, Tropical Spastic / Q000276:immunology / Q000382:microbiology; D012192:Retroviridae Infections / Q000150:complications* / Q000276:immunology
Dissemineret sklerose og retrovirus.