title: [Liver cancer and hepatitis B and C virus].
abstract: Chronic infection by hepatitis B and C viruses is frequently associated to the development of primary liver cancer. Liver cirrhosis, induced by these viral infection, plays an important role in the liver carcinogenesis. In addition, HBV has a direct role in liver cell transformation by a transactivating effect of some viral proteins as well as insertional mutagenesis. The role of hepatitis C virus is not known. The strong association, even in France, of primary liver cancer to these viral infections underline the importance of their prevention by vaccination.
authors.affiliation: Unité d'hépatologie, hôpital Laennec, Paris.
authors.forename: C
authors.initials: C
authors.lastname: Bréchot
mesh_terms: D006511:Hepatitis B Antigens / Q000235:genetics / Q000276:immunology; D006515:Hepatitis B virus; D006507:Hepatovirus; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000276:immunology / Q000382:microbiology*
chemical_list: D006511:Hepatitis B Antigens
vernacular_title: Cancer du foie et virus des hépatites B et C.