Prevention of kainate-induced excitotoxicity by a purine analogue.
The effect of a systematically administered adenosine analogue upon neuronal damage induced by kanic acid has been examined using the binding of a peripheral benzodiazepine receptor ligand as a marker for the gliosis following neuronal death. Intraperitoneal (i.p.) injections of R-phenylisopropyladenosine (R-PIA), at a dose of 100 micrograms kg-1 or 25 micrograms kg-1 reduced substantially the hippocampal neurotoxicity induced by intraperitoneal kainate 100 mg kg-1. The effect of R-PIA was prevented by 8-phenyl-theophylline, confirming the involvement of a purine P1 receptor.
MacGregor
D G
DG
Department of Pharmacology, University of Glasgow, Scotland.
Stone
T W
TW
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D002462:Cell Membrane / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D007546:Isoquinolines / Q000378:metabolism; D007608:Kainic Acid / Q000037:antagonists & inhibitors / Q000633:toxicity*; D007700:Kinetics; D008297:Male; D010660:Phenylisopropyladenosine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism*; D011983:Receptors, Purinergic / Q000187:drug effects / Q000378:metabolism*; D013806:Theophylline / Q000031:analogs & derivatives* / Q000494:pharmacology
D007546:Isoquinolines; D011963:Receptors, GABA-A; D011983:Receptors, Purinergic; D010660:Phenylisopropyladenosine; D013806:Theophylline; C028322:8-phenyltheophylline; D007608:Kainic Acid; C037850:PK 11195