Selectivity of serum immunoreactive prolyl 4-hydroxylase as a marker for hepatic necrosis.
To investigate the selectivity of serum immunoreactive prolyl 4-hydroxylase (S-IRPH) as a marker for hepatic necrosis, sera were taken from patients with hepatic inflammation and hepatic necrosis. The concentration of immunoreactive prolyl 4-hydroxylase in the sera was determined by radio-immunoassay, and S-IRPH and alanine aminotransferase (ALT) data were plotted. Patients with hepatic necrosis showed mainly prolyl 4-hydroxylase elevation while patients with inflammation had both prolyl 4-hydroxylase and alanine aminotransferase elevations. The addition of serum immunoreactive prolyl 4-hydroxylase to current serum markers would be useful in investigating the pathophysiology of hepatocellular damage, particularly in differentiating between hepatic necrosis and inflammation.
Nagai
Y
Y
First Department of Medicine, Faculty of Medicine, University of Tokyo, Japan.
Kato
M
M
Toda
G
G
D000328:Adult; D000410:Alanine Transaminase / Q000032:analysis; D015415:Biomarkers / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000201:enzymology; D006505:Hepatitis / Q000097:blood / Q000201:enzymology; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology*; D008113:Liver Neoplasms / Q000201:enzymology; D008875:Middle Aged; D009336:Necrosis / Q000201:enzymology; D011393:Procollagen-Proline Dioxygenase / Q000032:analysis*; D011863:Radioimmunoassay; D014057:Tomography, X-Ray Computed
D015415:Biomarkers; D011393:Procollagen-Proline Dioxygenase; D000410:Alanine Transaminase