Primaquine-induced superoxide production by beta-thalassemic red blood cells.
Primaquine, a prooxidant antimalarial drug, incubated with human red blood cells (RBC) induced marked superoxide generation in the cells as detected by exogenous cytochrome c reduction. In the presence of primaquine, beta-thalassemic RBC produced significantly more superoxide than normal RBC, thus reflecting the vulnerability of beta-thalassemic cells to oxidative stress.
Grinberg
L N
LN
Department of Hematology, Hadassah University Hospital, Jerusalem, Israel.
Shalev
O
O
Goldfarb
A
A
Rachmilewitz
E A
EA
D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D011319:Primaquine / Q000494:pharmacology*; D013481:Superoxides / Q000097:blood*; D013789:Thalassemia / Q000097:blood*
D013481:Superoxides; D011319:Primaquine