title: Testicular circulatory isolation: a phase I study.
abstract: Antineoplastic agents may damage germinal epithelium. Testicular circulatory isolation (TCI) is a regional drug exclusion technique designed to minimize this. We evaluated the technical and anaesthetic aspects of TCI in 10 patients who underwent bilateral orchiectomy immediately thereafter. A modified aortic clamp was placed trans-scrotally across the left testicular pedicle without pre-medication or anaesthesia and left in place for 1 h, occluding testicular blood flow. Minimal pain and anxiety were reported during the procedure. There were no complications related to TCI in any patient. This study supports the institution of trials of TCI in young men about to receive fertility-threatening chemotherapy.
authors.affiliation: Department of Anesthesiology, John Cochran VA Medical Center, St. Louis, MO.
authors.forename: J J
authors.initials: JJ
authors.lastname: Gibbons
authors.forename: R O
authors.initials: RO
authors.lastname: Parra
authors.forename: G L
authors.initials: GL
authors.lastname: Andriole
authors.forename: F E
authors.initials: FE
authors.lastname: Johnson
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects; D003250:Constriction; D005240:Feasibility Studies; D005298:Fertility / Q000187:drug effects; D006801:Humans; D008297:Male; D009919:Orchiectomy; D010147:Pain Measurement; D012039:Regional Blood Flow; D013737:Testis / Q000098:blood supply* / Q000187:drug effects; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents