title: Signet-ring cell carcinoma of the prostate mimicking primary gastric carcinoma.
abstract: A post mortem examination of a 70 year old man, who died three years after a poorly differentiated adenocarcinoma of prostate had been diagnosed, showed widespread signet-ring cell carcinoma, with an associated linitis plastica. The signet-ring cells stained positively with prostatic specific antigen and with prostatic specific acid phosphatase, but failed to react with mucopolysaccharide staining. The electron microscopic appearance of the signet-ring cell tumour was due to the presence of large cytoplasmic vacuoles. This case emphasises the possibility that cases of metastatic signet-ring cell carcinoma may be prostatic in origin. This can be confirmed by specific immunohistochemical studies.
authors.affiliation: Department of Pathology, Rambam Medical Center, Haifa, Israel.
authors.forename: O
authors.initials: O
authors.lastname: Ben-Izhak
authors.forename: C
authors.initials: C
authors.lastname: Lichtig
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000556:secondary* / Q000648:ultrastructure; D000368:Aged; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D011471:Prostatic Neoplasms / Q000648:ultrastructure*; D013274:Stomach Neoplasms / Q000556:secondary* / Q000648:ultrastructure