title: The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1.
abstract: Platelet-activating factor (PAF), a phospholipid, exhibits a variety of potent inflammatory bioactivities that are mediated by a specific cell surface receptor. The gene for the human PAF receptor (PTAFR) has been isolated by hybridization with a guinea pig probe. The coding sequence contains no intervening sequences. The encoded protein is highly homologous to the guinea pig PAF receptor (82% identity) and contains seven putative transmembrane domains. The PAF receptor therefore appears to be a member of the G protein coupled family of receptors and exhibits significant similarity to many members of the family. Analysis of somatic cell hybrids suggests that the PAF receptor is encoded by a single gene on human chromosome 1.
authors.affiliation: ICOS Corporation, Bothell, Washington 98021.
authors.forename: C E
authors.initials: CE
authors.lastname: Seyfried
authors.forename: V L
authors.initials: VL
authors.lastname: Schweickart
authors.forename: R
authors.initials: R
authors.lastname: Godiska
authors.forename: P W
authors.initials: PW
authors.lastname: Gray
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D004247:DNA / Q000235:genetics; D015342:DNA Probes; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D010972:Platelet Activating Factor / Q000378:metabolism*; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface / Q000235:genetics*; D043562:Receptors, G-Protein-Coupled
chemical_list: D015342:DNA Probes; D010972:Platelet Activating Factor; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; C039351:platelet activating factor receptor; D004247:DNA