[The melanotic neuroectodermal tumor of childhood. Tumor identification with immunohistochemical methods. A case report].
The authors report a case of a melanotic neuroectodermal tumor of infancy occurring in the maxilla of a 6-month-old female infant. The tumor displayed a biphasic cellular pattern with small neuroblast-like cells and large melanocytic cells showing a highly characteristic immunophenotype. Both tumor cell types immunostained for neuron specific enolase (NSE) and vimentin. The melanocytoid cells reacted additionally with the anti-keratin antibody Kl 1 and with HMB 45, an antibody specific for melanocytic antigens. The melanotic neuroectodermal tumor of infancy usually runs a benign course, however, local recurrence and metastasis may occur. The course of the disease cannot be predicted from morphological findings.
Greschnoik
A
A
Institut für Pathologie, Universität, Tübingen, Bundesrepublik Deutschland.
Gärtner
H V
HV
Ehrenfeld
M
M
Schwenzer
N
N
D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008437:Maxilla / Q000473:pathology; D008441:Maxillary Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008544:Melanocytes / Q000473:pathology; D009373:Neoplasms, Germ Cell and Embryonal / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery
Der melanotische neuroektodermale Tumor des Kindesalters. Tumoridentifikation mit immunhistochemischen Methoden. Ein Fallbericht.