title: Synthesis and degradation of polyphosphate in the fission yeast Schizosaccharomyces pombe: mutations in phosphatase genes do not affect polyphosphate metabolism.
abstract: The fission yeast Schizosaccharomyces pombe was found to accumulate large amounts of polyphosphate, particularly when grown on arginine as the nitrogen source. Upon transfer to a medium without phosphate, polyphosphate was degraded and served as an endogenous phosphate reserve. When phosphate was added again after a prolonged period of phosphate starvation, fission yeast cells synthesized more polyphosphate than they had contained before starvation, a phenomenon known as over-compensation. Strains carrying mutated structural genes for three different phosphatases, pho1, pho2 or pho3, degraded polyphosphate at the same rate as the wild-type strain during phosphate starvation and showed the same type of over-compensation when phosphate was added again.
authors.affiliation: Botanisches Institut der Universität Basel, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Müller
authors.forename: B
authors.initials: B
authors.lastname: Westenberg
authors.forename: T
authors.initials: T
authors.lastname: Boller
authors.forename: A
authors.initials: A
authors.lastname: Wiemken
mesh_terms: D005800:Genes, Fungal; D009154:Mutation; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics* / Q000378:metabolism; D011122:Polyphosphates / Q000378:metabolism*; D012568:Schizosaccharomyces / Q000235:genetics* / Q000378:metabolism
chemical_list: D011122:Polyphosphates; D010744:Phosphoric Monoester Hydrolases