Time-dependent increases in Na+,K(+)-ATPase content of low-frequency-stimulated rabbit muscle.
Chronic low-frequency stimulation of rabbit fast-twitch muscle induced time-dependent increases in the concentration of the sarcolemmal Na+,K(+)-ATPase and in mitochondrial citrate synthase activity. The almost twofold increase in Na+,K(+)-ATPase preceded the rise in citrate synthase and was complete after 10 days of stimulation. We suggest that the increase in Na+,K(+)-ATPase enhances resistance to fatigue of low-frequency-stimulated muscle prior to elevations in aerobic-oxidative capacity.
Green
H J
HJ
Department of Kinesiology, University of Waterloo, Canada.
Ball-Burnett
M
M
Chin
E R
ER
Dux
L
L
Pette
D
D
D000818:Animals; D002950:Citrate (si)-Synthase / Q000378:metabolism; D004558:Electric Stimulation; D005260:Female; D008297:Male; D009132:Muscles / Q000201:enzymology* / Q000502:physiology; D011817:Rabbits; D012508:Sarcolemma / Q000201:enzymology; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D002950:Citrate (si)-Synthase; D000254:Sodium-Potassium-Exchanging ATPase