Evaluation of squamous cell carcinoma antigen (SCC-Ag) in the diagnosis and follow-up of patients with non-small cell lung carcinoma.
The usefulness of squamous cell carcinoma (SCC) antigen as a tumor marker was investigated in 72 patients with histologically verified non-small cell lung carcinoma (NSCLC). Increased level of SCC-Ag was observed in 41%, mostly in patients with squamous cell carcinoma (69%). Positive serum SCC-Ag was correlated with lymph node metastases and with the stage of disease. The positive rate of SCC-Ag observed in patients without and with nodal metastases was 52.9% and 84.2%, respectively. Positive SCC-Ag level was observed in 50% of Stage I, 71.4% of Stage II and 78.9% of Stage III patients with squamous cell carcinoma of the lung. The study proved that preoperative SCC-Ag determination in patients with squamous cell carcinoma of the lung and the course of levels of this marker during postoperative follow-up was of importance. A high preoperative and postoperative SCC-Ag value suggested a worse prognosis.
Nikliński
J
J
Clinic of Chest Surgery, Medical Academy, Bialystok, Poland.
Furman
M
M
Laudański
J
J
Kozłowski
M
M
D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D008297:Male; D015843:Serpins
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D015843:Serpins; C051072:squamous cell carcinoma-related antigen