[Clinical picture of congenital Cytomegalovirus infection in infants in their first year of life].
A study was made of the clinical picture of congenital cytomegaloviral infection in 40 children of the first year of life. The diagnosis was established on the basis of demonstration in all the patients of IgM antibodies to cytomegalovirus (IgM anti-CMV) by EIA with the aid of the commercial test systems. Besides, 81% of the children were found to have cytomegalic-specific cells in urine, 17.6% in saliva, and 72.5% demonstrated IgG anti-CMV (in accordance with EIA). The majority of the patients (70%) were born premature. The most typical clinical signs of congenital cytomegaloviral infection were adynamia, jaundice, liver and CNS injury, prenatal hypotrophy; 45% of the children had developmental abnormalities and stigmas of dysembryogenesis. In 97.5% of the mothers, the pregnancy ran a pathological course. The disease history often pointed to miscarriages (10%) and death of the children due to intrauterine infection in the early times after birth (15%).
Matveev
V A
VA
Kazinets
N M
NM
Son'kina
A A
AA
Stakhanova
V M
VM
D000914:Antibodies, Viral / Q000032:analysis; D003587:Cytomegalovirus / Q000276:immunology / Q000472:pathogenicity*; D003586:Cytomegalovirus Infections / Q000151:congenital* / Q000175:diagnosis / Q000209:etiology / Q000635:transmission; D004660:Encephalitis / Q000151:congenital* / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006525:Hepatitis, Viral, Human / Q000151:congenital* / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007223:Infant; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology*
D000914:Antibodies, Viral; D007075:Immunoglobulin M
Klinicheskaia kartina vrozhdennoĭ tsitomegalovirusnoĭ infektsii u deteĭ pervogo goda zhizni.