title: Creutzfeldt-Jakob disease with tubulovesicular structures: an ultrastructural study.
abstract: Tubulovesicular structures (TVS) have been consistently observed in brain tissue of the transmissible spongiform virus encephalopathies such as natural and experimental scrapie, bovine spongiform encephalopathy and experimentally induced Creutzfeldt-Jakob disease (CJD). TVS were recently demonstrated in 3 cases of naturally occurring CJD. We report here the presence of TVS in another human brain with CJD, as detected in all 3 specimens by thin section electron microscopy. Their occurrence in all types of spongiform encephalopathies, irrespective of the affected host and the strain of infectious agent, emphasizes their biological significance.
authors.affiliation: Department of Neurology, Regional Hospital, Zgierz, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Split
authors.forename: J
authors.initials: J
authors.lastname: Janusik
authors.forename: J
authors.initials: J
authors.lastname: Alwasiak
authors.forename: W
authors.initials: W
authors.lastname: Papierz
authors.forename: M
authors.initials: M
authors.lastname: Barcikowska
authors.forename: P P
authors.initials: PP
authors.lastname: Liberski
mesh_terms: D001253:Astrocytes / Q000648:ultrastructure; D002540:Cerebral Cortex / Q000503:physiopathology* / Q000648:ultrastructure; D003072:Cognition Disorders / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D007562:Creutzfeldt-Jakob Syndrome / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D009207:Myoclonus / Q000150:complications / Q000503:physiopathology; D012640:Seizures / Q000150:complications / Q000503:physiopathology; D013572:Synaptic Vesicles / Q000648:ultrastructure