A critical reappraisal of gastrointestinal complications of allogeneic bone marrow transplantation.
Gastrointestinal toxicity is a common early complication of allogeneic bone marrow transplants. Etiologies include mucosal damage from pretransplant conditioning, opportunistic infection, and graft-versus-host disease. Because the clinical, laboratory, radiographic, and histological findings of acute graft-versus-host disease are nonspecific, accurate diagnosis is difficult or impossible. We review the differential diagnosis of gastrointestinal complications of bone marrow transplants and implications for therapy.
Department of Medicine, UCLA School of Medicine 90024.
G J
GJ
Schiller
R P
RP
Gale
D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000276:immunology; D005753:Gastric Mucosa / Q000473:pathology; D005767:Gastrointestinal Diseases / Q000209:etiology*; D006086:Graft vs Host Disease / Q000276:immunology; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007413:Intestinal Mucosa / Q000473:pathology; D009894:Opportunistic Infections / Q000276:immunology; D014184:Transplantation, Homologous