Time course of PAF formation by gastrointestinal tissue in rats after castor oil challenge.
When castor oil was administered by gavage to rats, the duodenum and jejunum, but not the stomach, produced large amounts of platelet activating factor 3-7 h after oil challenge with a peak at 3 h. Intraluminal release of acid phosphatase was also markedly increased in the duodenum and jejunum of castor oil-treated rats, especially 3-5 h after oil challenge. No increase was observed in the stomach. There was a correlation between elevated release of acid phosphatase and intestinal hyperaemia.
Department of Experimental Pharmacology, University of Naples, Federico II, Italy.
A
A
Pinto
G
G
Autore
N
N
Mascolo
R
R
Sorrentino
A
A
Biondi
A A
AA
Izzo
F
F
Capasso
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D002368:Castor Oil / Q000494:pharmacology*; D004064:Digestive System / Q000187:drug effects / Q000378:metabolism*; D004386:Duodenum / Q000201:enzymology / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D006940:Hyperemia / Q000503:physiopathology; D007583:Jejunum / Q000201:enzymology / Q000378:metabolism; D007700:Kinetics; D008297:Male; D010972:Platelet Activating Factor / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains
D010972:Platelet Activating Factor; D002368:Castor Oil; D000135:Acid Phosphatase