[Anti-neutrophil cytoplasmic antibodies (ANCA): major progress in the diagnosis of vasculitis].
ANCA antibodies represent a family of autoantibodies directed against neutrophil enzymes. Immunofluorescence patterns allow to distinguish c-ANCAs from p-ANCAs. The detection of ANCAs is often a key element for the diagnosis of Wegener's granulomatosis, microperiarteritis, Churg-Strauss syndrome and idiopathic rapidly progressive glomerulonephritis. Although the pathogenic role of ANCAs is not firmly established, their detection often allows an early therapeutic decision in necrotizing vasculitides.
Service d'Immunologie-Transfusion, Hôpital Erasme, Bruxelles.
M
M
Goldman
C
C
Servais
M
M
Lambermont
C
C
Tielemans
A
A
Lambrechts
F
F
Mascart-Lemone
E
E
Dupont
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000302:isolation & purification*; D015415:Biomarkers; D015267:Churg-Strauss Syndrome / Q000276:immunology; D014890:Granulomatosis with Polyangiitis / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000302:isolation & purification*; D007158:Immunologic Techniques; D010488:Polyarteritis Nodosa / Q000276:immunology; D014657:Vasculitis / Q000175:diagnosis / Q000276:immunology*
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D015415:Biomarkers; D007074:Immunoglobulin G
Les anticorps anti-cytoplasme des neutrophiles (ANCAs): un progrès majeur dans le diagnostic des vasculites.