Quantitative assessment of psychomotor activity in patients with neuroleptic-induced akathisia.
1. An ambulatory activity monitor with solid-state memory was employed to obtain 24-hour activity data in 29 neuroleptic-treated hospitalized patients and 9 normal controls. 2. The activity monitor is a piezoelectric device which was strapped to the non-dominant ankle. Activity was recorded in 5-minute epochs throughout the 24-hour period. 3. In contrast to patients with mania (N = 15) and schizophrenia (N = 4), depressed patients (N = 9) had higher clinical ratings of akathisia and lower levels of daytime activity. 4. Manic and depressed patients showed a delay of peak activity (= acrophase). 5. Quantifiable alterations in rest-activity rhythms may occur in neuroleptic-induced akathisia but measurement of activity may be complicated by the patient's psychiatric disorder.
Affective Disorders Program, McLean Hospital, Belmont, Massachusetts 02178.
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G
Gardos
M H
MH
Teicher
J F
JF
Lipinski
J D
JD
Matthews
L
L
Morrison
C
C
Conley
J O
JO
Cole
D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000139:chemically induced / Q000523:psychology; D002940:Circadian Rhythm / Q000187:drug effects; D003863:Depression / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000187:drug effects*; D011595:Psychomotor Agitation / Q000523:psychology*; D012565:Schizophrenic Psychology
D014150:Antipsychotic Agents