On the role of interleukin-2 (IL-2) in multiple sclerosis (MS). IL-2-mediated endothelial cell activation.
Increased serum levels of IL-2 and sIL-2R can be demonstrated in patients with active MS, a finding that strongly supports the hypothesis of a systemic T cell activation in such patients. However, IL-2 may play a crucial role in MS immunopathology by activating endothelial cells, as suggested by the vascular leak syndrome complicating hrIL-2 therapy. Early BBB impairment and focal perivascular edema that characterize MS lesions may be the effect of an IL-2-induced cytokine cascade.
Istituto di Neurologia, II Clinica Neurologica, Università di Padova.
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P
Gallo
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S
Pagni
M G
MG
Piccinno
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B
Giometto
V
V
Argentiero
M
M
Chiusole
F
F
Bozza
B
B
Tavolato
D001812:Blood-Brain Barrier; D016207:Cytokines / Q000502:physiology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology* / Q000502:physiology; D009103:Multiple Sclerosis / Q000097:blood / Q000276:immunology / Q000378:metabolism*
D016207:Cytokines; D007376:Interleukin-2