The human heat-shock genes HSPA6 and HSPA7 are both expressed and localize to chromosome 1.
HSPA6 is a member of the human heat-shock protein gene family, encoding a basic 70-kDa protein, with unique induction characteristics (Leung et al., 1990, Biochem. J. 267: 125-132). Hybridization analyses with a somatic cell hybrid DNA panel localized the gene to chromosome 1q. The highly related HSPA7 DNA sequence (Voellmy et al., 1985, Proc. Natl. Acad. Sci. USA 82: 4949-4953) colocalized. Both HSPA6 and HSPA7 represent functional genes, as determined by analyses of mRNA from heat-shocked human cells using specific oligonucleotides, although their pattern of expression differed. Neither mRNA was detected in the absence of heat stress. A BamHI polymorphism in the HSPA7 gene was present in a predominantly Asian population.
Department of Neurochemistry, Institute of Neurology, London, United Kingdom.
T K
TK
Leung
C
C
Hall
M
M
Rajendran
N K
NK
Spurr
L
L
Lim
D001483:Base Sequence; D002460:Cell Line; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D004247:DNA; D015245:Deoxyribonuclease BamHI / Q000378:metabolism; D015870:Gene Expression; D006367:HeLa Cells; D006360:Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D012150:Polymorphism, Restriction Fragment Length; D015183:Restriction Mapping
D006360:Heat-Shock Proteins; D004247:DNA; D015245:Deoxyribonuclease BamHI