Correlation of L-myc RFLP with metastasis, prognosis and multiple cancer in lung-cancer patients.
For further study of the correlation of L-myc restriction-fragment-length polymorphism (RFLP) and metastasis of lung cancer to lymph nodes or other organs at the time of surgery, L-myc RFLP was analyzed in 252 Japanese lung-cancer patients. A close correlation between L-myc RFLP and metastasis was confirmed in this large number of patients (p = 0.01). The correlation was particularly pronounced in cases of adenocarcinoma and squamous-cell carcinoma. Poor prognosis (additional metastases after surgery) was observed in lung-cancer patients with L-S (identified as long and short bands produced with EcoRI) and S-S type L-myc RFLP. In addition, the death rate of lung-cancer patients with the L-S and S-S types was greater than that of those with the L-L type. Lung-cancer patients of the L-S and S-S types had almost 4 times higher incidence of multiple cancer in the lung, pharynx and other organs than those with the L-L type. Our results indicate that, in patients with lung cancer, genetic disposition with respect to the L-myc gene influences the extent of metastasis, the incidence of multiple cancers and prognosis.
Biology Division, National Cancer Center Research Institute, Tokyo, Japan.
K
K
Kawashima
S
S
Nomura
H
H
Hirai
S
S
Fukushi
T
T
Karube
K
K
Takeuchi
T
T
Naruke
S
S
Nishimura
D003131:Combined Modality Therapy; D016259:Genes, myc; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D008207:Lymphatic Metastasis; D009362:Neoplasm Metastasis; D009378:Neoplasms, Multiple Primary / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D011379:Prognosis; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*; D012737:Sex Factors; D012907:Smoking; D016019:Survival Analysis
D016271:Proto-Oncogene Proteins c-myc