Alkyllysophospholipid prevents induction of experimental allergic encephalomyelitis.
Alkyllysophospholipids are synthetic analogues of natural phospholipids possessing a high immunomodulating and antitumoral capacity. Experimental autoimmune encephalomyelitis is a model disease for multiple sclerosis which can be induced by injecting rats with myelin basic protein, MBP. The effect of one alkyllysophospholipid, ET-18-OCH3, on the course of experimental autoimmune encephalomyelitis was investigated. It was found that animals treated with ET-18-OCH3 showed only weak signs of disease. MBP specific T-cell lines were co-cultivated with ET-18-OCH3. The compound suppressed T-cell proliferation markedly, suggesting that this might be its mode of action in vivo. Since ET-18-OCH3 has only low toxicity in man, it could be of interest to perform further studies on its effects on autoimmune, demyelinating disease.
Max-Planck-Institut für Immunobiologie, Freiburg, Germany.
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Klein-Franke
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Munder
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D008213:Lymphocyte Activation; D004676:Myelin Basic Protein; D010742:Phospholipid Ethers / Q000008:administration & dosage*; D051381:Rats; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes
D000276:Adjuvants, Immunologic; D004676:Myelin Basic Protein; D010742:Phospholipid Ethers; C026659:edelfosine