Urate excretion by the cat kidney.
1. The renal handling of urate by the cat kidney was investigated during continuous infusion of urate. 2. Fractional urate excretion (FE(UA)) in cats was 0.57 +/- 0.04, indicating net reabsorption of urate. In contrast, FE(UA) in rabbits was 1.76 +/- 0.08, reflecting net secretion of urate. 3. Fractional PAH excretion (FE(PAH)) was 3.94 +/- 0.26 in cats and 4.12 +/- 0.76 in rabbits, showing net secretion in both species. 4. FE(UA) in cats was dependent on urine flow, but was independent of plasma urate concentration. 5. The urate excretion in cats was enhanced by probenecid, but was insensitive to PAH and PZA. 6. The PAH excretion in cats was reduced by probenecid, but was unaltered by urate and PZA. 7. These results indicate that urate is handled in the cat kidney by a unique transport system which is distinct from that for organic anions.
Kim
Y K
YK
Department of Physiology, College of Medicine, Pusan National University, Korea.
Jung
D K
DK
Jung
J S
JS
Lee
S H
SH
D000818:Animals; D002415:Cats; D005260:Female; D007668:Kidney / Q000378:metabolism*; D008297:Male; D011339:Probenecid / Q000494:pharmacology; D011718:Pyrazinamide / Q000031:analogs & derivatives / Q000494:pharmacology; D014527:Uric Acid / Q000378:metabolism / Q000652:urine*; D010130:p-Aminohippuric Acid / Q000494:pharmacology / Q000652:urine
D014527:Uric Acid; D011718:Pyrazinamide; C005296:pyrazinoic acid; D011339:Probenecid; D010130:p-Aminohippuric Acid