Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes.
The nucleotide sequence of a 7.2-kb segment containing the mouse IL-10 (mIL-10) gene was determined. Comparison to the mIL-10 cDNA sequence (Moore, K. W., et al. 1990. Science 248:1230; 250:494) revealed the presence of five exons that span approximately 5.1 kb of genomic DNA. The noncoding regions of the mIL-10 gene contain sequences that have been associated with transcriptional regulation of several cytokine genes. The mIL-10 gene was mapped to mouse chromosome 1 and the human IL-10 gene was also mapped to human chromosome 1.
Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304.
J M
JM
Kim
C I
CI
Brannan
N G
NG
Copeland
N A
NA
Jenkins
T A
TA
Khan
K W
KW
Moore
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D005786:Gene Expression Regulation; D005796:Genes; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D016366:Open Reading Frames; D012150:Polymorphism, Restriction Fragment Length; D012045:Regulatory Sequences, Nucleic Acid; D015183:Restriction Mapping
D009838:Oligodeoxyribonucleotides; D016753:Interleukin-10