[Movement of gastric acid secretion and influence of proton pump inhibitors on histamine H2 receptor antagonist resistant ulcer].
Treatment of peptic ulcers has become easier with the advent of H2 blockers. However, H2 resistant ulcer still remain. These cases were screened by 24 hr-intragastric pH monitoring, which well reflects the status of gastric acid secretion. On the one hand, there were cases in which no nocturnal elevation in gastric pH was seen even after administration of H2 blocker (H2 blocker resistant ulcer). On the other hand, there were cases which were resistant to treatment with H2 blocker, although the gastric pH elevated. It is considered that omeprazole is effective for the former cases.
Third Department of Internal Medicine, School of Medicine, Tohoku University.
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Asaki
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Kimpara
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Ohara
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Hongo
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000328:Adult; D003864:Depression, Chemical; D004351:Drug Resistance; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D017506:H(+)-K(+)-Exchanging ATPase; D006635:Histamine H2 Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000494:pharmacology* / Q000627:therapeutic use; D010437:Peptic Ulcer / Q000188:drug therapy / Q000503:physiopathology*; D013997:Time Factors
D006635:Histamine H2 Antagonists; D000251:Adenosine Triphosphatases; D017506:H(+)-K(+)-Exchanging ATPase; D009853:Omeprazole