Programmed death of T cells in HIV-1 infection.
In human immunodeficiency virus (HIV) infection, functional defects and deletion of antigen-reactive T cells are more frequent than can be explained by direct viral infection. On culturing, both CD4+ and CD8+ T cells from asymptomatic HIV-infected individuals died as a result of programmed cell death (apoptosis). Apoptosis was enhanced by activation with CD3 antibodies. Programmed cell death, associated with impaired T cell reactivity, may thus be responsible for the deletion of reactive T cells that contributes to HIV-induced immunodeficiency.
Department of Clinical Viro-Immunology, Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, Amsterdam.
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L
Meyaard
S A
SA
Otto
R R
RR
Jonker
M J
MJ
Mijnster
R P
RP
Keet
F
F
Miedema
D000163:Acquired Immunodeficiency Syndrome / Q000473:pathology*; D015703:Antigens, CD / Q000502:physiology; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology; D016827:CD8 Antigens / Q000276:immunology; D016923:Cell Death / Q000502:physiology; D002455:Cell Division / Q000276:immunology; D002478:Cells, Cultured; D015699:HIV Envelope Protein gp120 / Q000502:physiology; D015497:HIV-1; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D013601:T-Lymphocytes / Q000473:pathology*; D015032:Zinc / Q000494:pharmacology
D015703:Antigens, CD; D016827:CD8 Antigens; D015699:HIV Envelope Protein gp120; D015032:Zinc