K-opioid receptor changes in experimental models of cerebral ischaemia and atherosclerosis in the rabbit.
Thromboembolic phenomena and transient ischaemic attacks (TIA) are considered the basis of ischaemic pathologies. The aim of the present research is to investigate the involvement of k-opioid receptors in cerebral blood flow (CBF) impairment which results in experimental stroke or dietary atherosclerosis in rabbits. CBF measurement showed a significant decrease in rabbits submitted to embolization and/or atherosclerosis. Binding studies showed that massive cerebral ischaemia and atherosclerosis produced a significant increase in the number of k-opioid receptors (Bmax), without changing (KD) affinity values. In conclusion, the results obtained seem to indicate that the increase in k-opioid receptors might play a crucial role in a common cerebral biochemical mechanism both in ischaemic and atherosclerotic pathologies.
Institute of Pharmacology, University of Pavia, Italy.
A
A
Rozza
G
G
La Torre
C
C
Scavini
E
E
Lanza
L
L
Favalli
G
G
Racagni
D000818:Animals; D001161:Arteriosclerosis / Q000378:metabolism* / Q000503:physiopathology; D002545:Brain Ischemia / Q000378:metabolism* / Q000503:physiopathology; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000502:physiology; D004036:Diet, Atherogenic; D004399:Dynorphins / Q000378:metabolism; D004569:Electroencephalography / Q000187:drug effects; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects; D007700:Kinetics; D008055:Lipids / Q000097:blood; D011817:Rabbits; D017473:Receptors, Opioid, kappa / Q000378:metabolism*
D008055:Lipids; D017473:Receptors, Opioid, kappa; D004399:Dynorphins