Sensitivity of T cells to anti-CD3-stimulated suicide is independent of functional phenotype.
We have examined mixed populations and cloned murine CD4+ T cell lines for their sensitivity to anti-CD3-stimulated suicide. The sensitivity of CD4+ clones to anti-CD3-stimulated suicide is independent of their interleukin-2/interleukin-4 or interferon-gamma secretion profile or their lytic efficiency in anti-CD3 redirected lytic assays.
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110.
J H
JH
Russell
B J
BJ
Rush
S I
SI
Abrams
R
R
Wang
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D017252:CD3 Complex; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D016923:Cell Death / Q000276:immunology; D002999:Clone Cells; D016572:Cyclosporine / Q000494:pharmacology; D003601:Cytotoxicity Tests, Immunologic; D007371:Interferon-gamma / Q000502:physiology; D007376:Interleukin-2 / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D051379:Mice; D008811:Mice, Inbred DBA; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*
D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D007376:Interleukin-2; D011948:Receptors, Antigen, T-Cell; D015847:Interleukin-4; D007371:Interferon-gamma; D016572:Cyclosporine