IgG monoclonal proteins from patients with axonal peripheral neuropathies bind to different epitopes of the 68 kDa neurofilament protein.
We describe three patients with a sensorimotor axonal polyneuropathy and an IgG M-protein that binds to a 68 kDa axonal protein identified as the low molecular weight neurofilament protein (NF-L). The immunological studies revealed that the M-proteins have different target epitopes: one is phosphorylated and the other two are nonphosphorylated. One of the nonphosphorylated epitopes is common to other intermediate filaments, such as desmin and vimentin.
Department of Neurology, University of Milan, Italy.
R
R
Fazio
R
R
Nemni
A
A
Quattrini
I
I
Lorenzetti
N
N
Canal
D001369:Axons / Q000276:immunology*; D001798:Blood Proteins / Q000276:immunology*; D000939:Epitopes / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology*; D007136:Immunoglobulins; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D016900:Neurofilament Proteins / Q000276:immunology*; D010523:Peripheral Nervous System Diseases / Q000276:immunology* / Q000473:pathology; D010766:Phosphorylation
D001798:Blood Proteins; D000939:Epitopes; D007074:Immunoglobulin G; D007136:Immunoglobulins; C009823:M-proteins (Myeloma); D016900:Neurofilament Proteins