Does rilmenidine act in vivo on central alpha 2-adrenoceptors modulating noradrenaline release?
Noradrenaline release evoked by electrical stimulation was recorded in the rat hypothalamus by in vivo electrochemistry. Rilmenidine (0.3-10 mg kg-1 i.v.) did not diminish this evoked release while clonidine induced a dose-dependent decrease. These results further suggest that the antihypertensive action of rilmenidine is not mediated by central alpha 2-adrenoceptors and might explain why, unlike clonidine, rilmenidine does not have sedative effects.
INSERM U 171, Centre Hospitalier Lyon-Sud, Pierre-Bénite, France.
M F
MF
Suaud-Chagny
C
C
Mermet
E
E
Tibiriça
P
P
Bousquet
F
F
Gonon
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D003000:Clonidine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D010080:Oxazoles / Q000494:pharmacology*; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology*; D000077769:Rilmenidine
D000316:Adrenergic alpha-Agonists; D000959:Antihypertensive Agents; D010080:Oxazoles; D011942:Receptors, Adrenergic, alpha; D003000:Clonidine; D000077769:Rilmenidine; D009638:Norepinephrine