Detecting gene conversion: primate visual pigment genes.
The effects of gene conversion can be detected in the DNA sequences of multigene families. We develop a permutation test of the significance of patterns of sequence mismatches, and apply it to the sequences of the red- and green-sensitive visual pigment genes of human and the diana monkey. Whereas conventional tests of the rate of sequence divergence are equivocal, the permutation test convincingly excludes divergence in the absence of gene conversion (p = 10(-6)).
School of Mathematical Sciences, Queen Mary and Westfield College, University of London, U.K.
D J
DJ
Balding
R A
RA
Nichols
D M
DM
Hunt
D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D002521:Cercopithecus; D004247:DNA / Q000235:genetics; D005091:Exons; D005785:Gene Conversion; D006801:Humans; D008957:Models, Genetic; D008969:Molecular Sequence Data; D005810:Multigene Family; D012168:Retinal Pigments / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
D012168:Retinal Pigments; D004247:DNA