Gamma interferon modifies CD4+ subset expression in murine candidiasis.
A single injection of monoclonal antibody to gamma interferon administered in conjunction with a live Candida albicans yeast cell vaccine resulted in the detection of nonprotective Th2 rather than protective Th1 responses and altered the early expression of interleukin 4 and gamma interferon mRNA in CD4+ cells.
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy.
L
L
Romani
E
E
Cenci
A
A
Mencacci
R
R
Spaccapelo
U
U
Grohmann
P
P
Puccetti
F
F
Bistoni
D000818:Animals; D000946:Antigens, Fungal / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002176:Candida albicans / Q000276:immunology; D002177:Candidiasis / Q000276:immunology*; D015870:Gene Expression; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular; D007371:Interferon-gamma / Q000502:physiology*; D015847:Interleukin-4 / Q000235:genetics; D051379:Mice; D012333:RNA, Messenger / Q000235:genetics; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D000946:Antigens, Fungal; D012333:RNA, Messenger; D015847:Interleukin-4; D007371:Interferon-gamma