Bullatencin, 4-deoxyasimicin, and the uvariamicins: additional bioactive Annonaceous acetogenins from Annona bullata Rich. (Annonaceae).
Additional bioactive Annonaceous acetogenins have been isolated from the EtOH extract of the bark of Annona bullata Rich. by bioactivity-directed fractionation using lethality to brine shrimp. These acetogenins include bullatencin, a new single tetrahydrofuran acetogenin having a double bond in the hydrocarbon chain; 4-deoxyasimicin, a new adjacent bis-tetrahydrofuran acetogenin; and the uvariamicins, an isomeric mixture of four single tetrahydrofuran acetogenins showed selective cytotoxicities for certain human solid tumor cell lines comparable to or better than adriamycin.
Hui
Y H
YH
Department of Medical Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907.
Wood
K V
KV
McLaughlin
J L
JL
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D033364:Decapoda; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification*; D014407:Tumor Cells, Cultured / Q000187:drug effects
C087001:4-deoxyasimicin; D000972:Antineoplastic Agents, Phytogenic; D005663:Furans; D007783:Lactones; C087002:bullatencin