Magnetoelectrical stimulation of motor cortex in children with motor disturbances.
Transcranial magnetoelectrical stimulation (TMS) is now widely used as a diagnostic tool in adults. In this study we report our experiences with this technique in children with central motor disturbances. We used a Cadwell MES10 magnetoelectrical stimulator with a maximal magnetic field of 2 tesla. The stimulation procedure followed a standardized protocol, with the patients being as relaxed as possible in order to avoid contamination of parameters with different preinnervational levels. Stimulation data were compared to a data base obtained in 58 normal children. The first group of patients consisted of 20 children aged from 7 months to 16 years with hemiparesis of different etiologies. Neuroimaging data were correlated with the results of magnetoelectrical stimulation. In 13 patients a pathological pattern of TMS could be detected, and in 7 of these a corresponding lesion of the cortico-spinal tract was found in CT or MRI scans. In 7 children TMS was normal, in spite of a clear-cut lesion of the cortico-spinal tract in CT or MRI scans in 4 of them. The second group of patients consisted of 16 children with extrapyramidal disease, mostly of hereditary origin, such as DOPA-responsive dystonia or benign hereditary chorea. TMS showed a normal response pattern in this group. We discuss problems and possible pitfalls in TMS in childhood in evaluating the diagnostic value of TMS. At the moment the diagnostic usefulness of TMS in children with motor disturbances appears limited and calls for careful interpretation.
Department of Pediatrics, Heinrich-Heine-University, Düsseldorf, F.R.G.
K
K
Müller
V
V
Hömberg
A
A
Aulich
H G
HG
Lenard
D000293:Adolescent; D001480:Basal Ganglia Diseases / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D001927:Brain Diseases / Q000175:diagnosis / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D055590:Electromagnetic Phenomena; D004576:Electromyography; D005260:Female; D006429:Hemiplegia / Q000209:etiology*; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D016472:Motor Neuron Disease / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D009431:Neural Conduction / Q000502:physiology; D010812:Physical Stimulation / Q000379:methods; D011930:Reaction Time / Q000502:physiology; D014057:Tomography, X-Ray Computed