[Comparative study of the efficacy and tolerance of cetirizine verses astemizole in patients with allergic rhinitis].
Thirty four patients with allergic rhinitis were included in two randomized groups and treated with Cetirizine and Astemizole respectively, 10 mg/day in oral administration during 15 days. This study was designed in order to compare the efficacy and tolerance of Cetirizine versus Astemizole, with special reference on the collateral effects on the central nervous system. Although both drugs showed good results. Cetirizine had a statistically significant better outcome in the evolution of symptoms, above all at the second day of treatment. Also it showed superior results, based on a subjective approach, related to the rapidity, power and efficacy of its action.
Servicio de Otorrinolaringología, Hospital Central de Asturias, Universidad de Oviedo.
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P
Barthe
J R
JR
Gómez
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C
Suárez
S
S
Ferro
B
B
Figueres
D000328:Adult; D000368:Aged; D016589:Astemizole / Q000627:therapeutic use*; D017332:Cetirizine; D004361:Drug Tolerance; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D006919:Hydroxyzine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012220:Rhinitis / Q000188:drug therapy*
D006634:Histamine H1 Antagonists; D006919:Hydroxyzine; D016589:Astemizole; D017332:Cetirizine
Estudio comparativo sobre la eficacia y tolerancia de la cetirizina frente al astemizol en enfermos afectos de rinitis alérgica.