[The polyphosphoinisitide response evoked by different neuromediators after exposure to a helium-oxygen environment under increased pressure].
Male Wistar rats were subjected to normoxic helium-oxygen mixture under 40 kg/cm2 pressure with subsequent decompression. Their brain's Ach, dopamine, glutamate, substance P were shown to change the turnover rate of the synaptosomal PPI. The findings suggest an unspecific mechanism of action of high tension helium on the neurons. The data obtained shows the high pressure neural syndrome not to be connected with metabolic change of a single neurotransmitter.
E I
EI
Tiul'kova
A Iu
AIu
Sledkov
D000818:Animals; D001274:Atmospheric Pressure; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004780:Environment, Controlled; D006371:Helium; D008297:Male; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D010100:Oxygen; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism
D018377:Neurotransmitter Agents; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; D006371:Helium; D010100:Oxygen
Polifosfoinozitidnyĭ otvet, vyzvannyĭ razlichnymi neĭromediatorami, posle vozdeĭstviia geliokislorodnoĭ sredy pod povyshennym davleniem.