On the role of interleukin-2 (IL-2) in multiple sclerosis (MS). IL-2-mediated endothelial cell activation.
Increased serum levels of IL-2 and sIL-2R can be demonstrated in patients with active MS, a finding that strongly supports the hypothesis of a systemic T cell activation in such patients. However, IL-2 may play a crucial role in MS immunopathology by activating endothelial cells, as suggested by the vascular leak syndrome complicating hrIL-2 therapy. Early BBB impairment and focal perivascular edema that characterize MS lesions may be the effect of an IL-2-induced cytokine cascade.
Gallo
P
P
Istituto di Neurologia, II Clinica Neurologica, Università di Padova.
Pagni
S
S
Piccinno
M G
MG
Giometto
B
B
Argentiero
V
V
Chiusole
M
M
Bozza
F
F
Tavolato
B
B
D001812:Blood-Brain Barrier; D016207:Cytokines / Q000502:physiology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology* / Q000502:physiology; D009103:Multiple Sclerosis / Q000097:blood / Q000276:immunology / Q000378:metabolism*
D016207:Cytokines; D007376:Interleukin-2