No association between RFLPs at the porphobilinogen deaminase gene and schizophrenia.
An association study of restriction fragment length polymorphisms (RFLPs) in the porphobilinogen deaminase (PBGD) gene and schizophrenia was conducted. RFLPs detected by MspI, PstI, ApaLI and BstNI in intron 1 of the gene were studied in 49 patients and 79 controls. There were no significant differences between the groups in allele frequencies, genotype counts or haplotype distribution.
Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK.
M J
MJ
Owen
R
R
Mant
E
E
Parfitt
J
J
Williams
P
P
Asherson
G
G
O'Mahoney
J
J
Van Os
D
D
Llewellyn
D
D
Collier
M
M
Gill
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D005260:Female; D006801:Humans; D011163:Hydroxymethylbilane Synthase / Q000235:genetics*; D007438:Introns / Q000235:genetics; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D012559:Schizophrenia / Q000201:enzymology* / Q000235:genetics
D011163:Hydroxymethylbilane Synthase