Rapid evolution of peptide and protein binding properties in vitro.
A significant bottleneck in protein engineering arises from the problem of identifying particular molecules with new functions from a potentially enormous range of peptide or protein variants. Two areas of emerging technology, phage display and multiple peptide synthesis, provide new means of screening huge libraries in vitro for novel binding properties. This review is also published in Current Opinion in Structural Biology 1992, 2:597-604.
Wells
J A
JA
Department of Protein Engineering, Genentech Inc., South San Francisco, California 94080.
Lowman
H B
HB
D001435:Bacteriophages / Q000235:genetics; D010455:Peptides / Q000378:metabolism*; D011485:Protein Binding; D015202:Protein Engineering; D011506:Proteins / Q000378:metabolism*
D010455:Peptides; D011506:Proteins