Immunization with fimbrial protein and peptide protects against Porphyromonas gingivalis-induced periodontal tissue destruction.
In these studies we have attempted to show that cell surface structures are critical antigens for protection against P. gingivalis-induced periodontal destruction. Fimbrillin, and in particular a synthetic 20-amino-acid fimbrillin peptide, exerts a protective effect in gnotobiotic rats, thus identifying them as potentially useful in the development of a vaccine.
School of Dental Medicine, Department of Oral Biology, State University of New York, Buffalo 14214.
R T
RT
Evans
B
B
Klausen
R J
RJ
Genco
D016301:Alveolar Bone Loss / Q000276:immunology / Q000517:prevention & control; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis / Q000097:blood; D001426:Bacterial Proteins / Q000276:immunology*; D001442:Bacteroides Infections / Q000276:immunology / Q000517:prevention & control*; D010861:Fimbriae, Bacterial / Q000276:immunology*; D005881:Gingiva / Q000276:immunology; D008297:Male; D010455:Peptides / Q000276:immunology*; D010510:Periodontal Diseases / Q000276:immunology / Q000517:prevention & control*; D016966:Porphyromonas gingivalis / Q000276:immunology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000907:Antibodies, Bacterial; D001426:Bacterial Proteins; D010455:Peptides