Effects of somatostatin on inositol-1,4,5-trisphosphate content in mouse spleen lymphocytes.
1. The effects of somatostatin-14 (SS) and diazepam in vitro on the content of inositol-1,4,5-trisphosphate (IP3) in mouse spleen lymphocytes were investigated. 2. It was found that the exposure of mouse spleen lymphocytes in vitro to SS sharply diminished their IP3 level. 3. Diazepam had no effect on lymphocytes IP3 content. 4. The inhibition of phosphatydyloinositol (PI) breakdown was suggested as one of the mechanisms of the physiological SS action.
Lachowicz
A
A
Institute of Endocrinology, Medical Academy of Lódź, Poland.
Stepień
H
H
Kunert-Radek
J
J
Pawlikowski
M
M
D000818:Animals; D003975:Diazepam / Q000494:pharmacology; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism*; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013004:Somatostatin / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology*
D013004:Somatostatin; D015544:Inositol 1,4,5-Trisphosphate; D003975:Diazepam