Biochemical variables associated with bone density in patients with primary hyperparathyroidism.
OBJECTIVE
To clarify the association between primary hyperparathyroidism and cortical osteopenia.


METHODS
Open study.


METHODS
Department of Surgery, University of Lund, Sweden.


METHODS
38 patients with primary hyperparathyroidism.


METHODS
Correlation between bone density (measured by single photon absorption) and age; sex; serum concentrations of parathyroid hormone and ionised calcium; serum alkaline phosphatase activity; and serum concentration of calcium, phosphate, creatinine, urea, osteocalcin, 25 hydroxycholecalciferol, and 1,25 dihydroxycholecalciferol.


RESULTS
There was no difference in bone density between men and women. There was no correlation between bone density and severity of hypercalcaemia or age. No biochemical abnormality was peculiar to the seven patients whose bone density was more than two SD below the population mean. Serum concentrations of 1,25 dihydroxycholecalciferol and osteocalcin both correlated significantly with bone density (p < 0.05) and there was a strong correlation between serum osteocalcin and serum intact parathyroid hormone (p < 0.001). Serum osteocalcin had the strongest correlation with bone density of any of the biochemical variables.


CONCLUSIONS
There is little association between bone density and serum concentration of parathyroid hormone.
Bergenfelz
A
A
Department of Surgery, Lund University, Sweden.
Lindergård
B
B
Ahrén
B
B
D015502:Absorptiometry, Photon; D015519:Bone Density; D002118:Calcium / Q000097:blood; D002762:Cholecalciferol / Q000097:blood; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000453:epidemiology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D010281:Parathyroid Hormone / Q000097:blood
D010281:Parathyroid Hormone; D015675:Osteocalcin; D002762:Cholecalciferol; D002118:Calcium