Selectivity of Thy-1 monoclonal antibodies in enhancing neurite outgrowth.
Thy-1 monoclonal antibodies (MAbs) have previously been shown to promote neurite outgrowth from retinal ganglion cells and a variety of other neurons. We have studied the effect on neurite outgrowth of several Thy-1 MAbs with quantitatively similar binding properties and found that only certain Thy-1 MAbs promote neurite outgrowth. This finding suggests that the antibody effects depend on specific interactions with one or more active sites on the Thy-1 glycoprotein.
Lipton
S A
SA
Department of Neurology, Children's Hospital, Boston, MA 02115.
Leifer
D
D
Barnstable
C J
CJ
D000818:Animals; D000911:Antibodies, Monoclonal; D000915:Antibody Affinity; D000918:Antibody Specificity; D000954:Antigens, Surface / Q000276:immunology / Q000502:physiology*; D002478:Cells, Cultured; D007518:Isoantibodies; D008562:Membrane Glycoproteins / Q000276:immunology / Q000502:physiology*; D051379:Mice; D016501:Neurites / Q000648:ultrastructure*; D051381:Rats; D012165:Retinal Ganglion Cells / Q000166:cytology*; D018800:Thy-1 Antigens
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D007518:Isoantibodies; D008562:Membrane Glycoproteins; D018800:Thy-1 Antigens; C035678:anti-Thy antibody