[Teratologic studies of methyl 5-aminosalicylate and salicylazopyridine].
Methyl 5-aminosalicylate hydrochloride (M-5-AS) at the dosages of 21, 42, 209, and 417 mg.kg-1.d-1 ig to mice during d 6-15 of pregnancy, no obvious effects on the placenta, fetus weight, sex differentiation, external appearance, visceral, and skeletal development were observed. In rats ig M-5-AS 56 and 556 mg.kg-1.d-1 produced no noticeable effects on the organogenesis or teratogenesis either. In mice and rats ig salicylazopyridine 410 and 1089 mg.kg-1.d-1 respectively no obvious teratogenicity was detected. However, aspirin 250 mg.kg-1.d-1 ig did bring about significant teratogenicity in rats.
Institute of Materia Medica, Kunming Pharmaceutical Factory, China.
J M
JM
Xiong
B
B
Liang
Y Q
YQ
Mo
Z H
ZH
Chen
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000636:Aminosalicylic Acids / Q000633:toxicity*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity*; D020964:Embryo Loss / Q000139:chemically induced; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D051379:Mice; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012460:Sulfasalazine / Q000633:toxicity*
D000636:Aminosalicylic Acids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D012460:Sulfasalazine; C065760:methyl 5-aminosalicylate