Protective effects of verapamil on cis-platinum and carboplatinum nephrotoxicity in dehydrated and normohydrated rats.
The aim of the study was to compare the nephrotoxic effects of cis-platinum (CDDP) and carboplatinum (CBDCA) and the protective potential of verapamil in rats. CDDP (3 mg/kg) and CBDCA (60 mg/kg) were administered intraperitoneally in a single dose on day 1. Verapamil (0.1 mg/kg) was administered 30 min before i.p. injection. Rats were assayed daily for urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG), alkaline phosphatase (AP) and gamma-glutamyl-transferase (GMT), on day 3 they were assayed for creatinine clearance. CBDCA appears to be less nephrotoxic than CDDP. Verapamil shows protective effects against the nephrotoxicity of platinum derivatives in both groups of rats.
Haragsim
L
L
Institute of Toxicology, Charles University School of Medicine, Prague, Czechoslovakia.
Zima
T
T
D000118:Acetylglucosaminidase / Q000652:urine; D000469:Alkaline Phosphatase / Q000652:urine; D000818:Animals; D016190:Carboplatin / Q000008:administration & dosage / Q000633:toxicity*; D002945:Cisplatin / Q000008:administration & dosage / Q000633:toxicity*; D003681:Dehydration / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014700:Verapamil / Q000008:administration & dosage / Q000494:pharmacology*; D005723:gamma-Glutamyltransferase / Q000652:urine
D016190:Carboplatin; D014700:Verapamil; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D000118:Acetylglucosaminidase; D002945:Cisplatin