Dysregulation of gene expression in mouse trisomy 16, an animal model of Down syndrome.
In humans, trisomy 21 results in a specific phenotype known as Down syndrome (DS). The mechanism by which an extra copy of normal genes leads to the DS phenotype is unknown. Most studies in DS and other aneuploid organisms have shown that gene dose is proportional to gene expression. To date, most genes examined have encoded either metabolic enzymes or constitutively expressed products. In the trisomy 16 mouse, an animal model of DS, we found marked dysregulation of two developmentally regulated genes, App and Prn-p. Dysregulation varied from tissue to tissue and during development in the same tissue. We conclude that abnormal phenotypes seen in aneuploid conditions may result in part from disordered expression of developmentally regulated genes.
Holtzman
D M
DM
Department of Neurology, University of California, San Francisco 94143.
Bayney
R M
RM
Li
Y W
YW
Khosrovi
H
H
Berger
C N
CN
Epstein
C J
CJ
Mobley
W C
WC
D000782:Aneuploidy; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D001921:Brain / Q000196:embryology*; D002678:Chimera; D004195:Disease Models, Animal; D004314:Down Syndrome / Q000235:genetics*; D004622:Embryo, Mammalian; D005260:Female; D005786:Gene Expression Regulation; D005865:Gestational Age; D006321:Heart / Q000196:embryology; D008168:Lung / Q000196:embryology; D051379:Mice; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides; D016376:Oligonucleotides, Antisense; D010920:Placenta / Q000502:physiology; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D012313:RNA / Q000235:genetics / Q000302:isolation & purification; D012333:RNA, Messenger / Q000235:genetics; D012867:Skin / Q000196:embryology*; D013482:Superoxide Dismutase / Q000235:genetics; D014158:Transcription, Genetic; D014314:Trisomy
D009838:Oligodeoxyribonucleotides; D016376:Oligonucleotides, Antisense; D012333:RNA, Messenger; D012313:RNA; D013482:Superoxide Dismutase