Cyanide selectively augments kainate- but not NMDA-induced release of glutamate and taurine.
The effect of cyanide on the kainate-, quisqualate- and N-methyl-D-aspartate (NMDA)-induced release of several amino acids from cerebellar granule neurons was studied. Cyanide, 100 microM, augmented the kainate- and quisqualate-induced release of glutamate and taurine in neurons but had no effect on the NMDA-induced release of these excitatory amino acids. In addition to the interaction with the above excitatory amino acids, cyanide had effects on several amino acids independent of excitatory amino acid stimulation; cyanide treatment resulted in a significant elevation over saline controls of arginine and taurine, but not alanine, aspartate+asparagine or glycine. With the exception of taurine, this pattern was not apparent in cells treated with any of the above excitatory amino acid.
Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson 39216-4505.
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McCaslin
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Yu
D000818:Animals; D002478:Cells, Cultured; D002531:Cerebellum / Q000378:metabolism*; D003486:Cyanides / Q000633:toxicity*; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D007608:Kainic Acid / Q000378:metabolism*; D016202:N-Methylaspartate / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D016318:Quisqualic Acid / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D017459:Receptors, Amino Acid / Q000378:metabolism; D013654:Taurine / Q000378:metabolism
D003486:Cyanides; D005971:Glutamates; D017459:Receptors, Amino Acid; D013654:Taurine; D018698:Glutamic Acid; D016202:N-Methylaspartate; D016318:Quisqualic Acid; D007608:Kainic Acid