[Dexamethasone Sodium Phosphate Reference Standard (Control 891) of National Institute of Hygienic Sciences].
The raw material of dexamethasone sodium phosphate was examined for preparation of the "Dexamethasone Sodium Phosphate Reference Standard". Analytical results were as follows: UV spectrum indicates absorption maxima at 242 nm and absorptivity at 242 nm is E1%1cm 304; optical rotation +79.0%; pH 7.7; ethanol 5.2%; water 6.0%; HPLC analysis indicates small amounts of three impurities and the purity was assumed to be 99.8%; assay by HPLC indicated 100.9% against the USP Reference Standard of "Dexamethasone Phosphate". Based on the results, the present raw material was authorized to be the Reference Standard of the National Institute of Hygienic Sciences.
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Okada
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Hiroshige
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Tanaka
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Murai
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Kimura
D002851:Chromatography, High Pressure Liquid; D003907:Dexamethasone / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000592:standards; D006077:Government Agencies; D006920:Hygiene; D007564:Japan; D010602:Pharmacopoeias as Topic
C004180:dexamethasone 21-phosphate; D003907:Dexamethasone