Decreased striatal D2 dopamine receptors in obese Zucker rats: changes during aging.
The specific binding of [3H]YM-09151-2 was used to investigate the possible differences in age-associated changes in striatal D2 dopamine (DA) receptor properties in genetically obese (fa/fa) Zucker rats and their lean (Fa/?) littermates. The maximal binding sites (Bmax) of D2 DA receptors was found to decline with age in both obese and lean rats; the rate of decline in receptor Bmax was slightly higher in lean than obese rats. However, the Bmax of D2 DA receptor in 6-, 12- and 18-month-old obese rats was significantly lower compared to the age-matched lean rats. These data indicate that obesity decreases the number of striatal D2 DA receptors without affecting the rate at which receptor number decreases with age.
Laboratory of Neurosciences, Pennington Biomedical Research Center, Baton Rouge, LA 70808.
A
A
Hamdi
J
J
Porter
C
C
Prasad
D000375:Aging / Q000378:metabolism*; D000818:Animals; D014150:Antipsychotic Agents / Q000378:metabolism; D001549:Benzamides / Q000378:metabolism; D001835:Body Weight / Q000502:physiology; D007700:Kinetics; D008297:Male; D009765:Obesity / Q000378:metabolism*; D051381:Rats; D011924:Rats, Zucker; D017448:Receptors, Dopamine D2 / Q000378:metabolism*
D014150:Antipsychotic Agents; D001549:Benzamides; D017448:Receptors, Dopamine D2; C030265:nemonapride