Evaluation of ion-exchange microspheres as carriers for the anticancer drug doxorubicin: in-vitro studies.
A comparison study of doxorubicin loading, release characteristics and stability within sodium and hydrogen forms of ion-exchange resin microspheres has been performed. It was demonstrated that resins in the Na+ form, although having lower drug loading capacity, showed similar release profiles to resins in the H+ form but still maintain all the drug activity. Resins in the H+ form, despite having high drug loading capacity, caused drug degradation within microspheres due to their strong acidic nature. Therefore, in comparison with the H+ form, resins in the Na+ form can be considered as better carriers for doxorubicin in terms of sustaining the release of drug and maintaining drug activity. Other factors such as the degree of resin cross-linkage and drug/resin mixing time have also been examined in relation to drug loading and release characteristics. Overall, this study demonstrated the significance of the characteristics of matrix materials and their influence on the drug activity and microsphere performance in-vitro.
Department of Surgery, University of Western Australia, Royal Perth Hospital.
Y
Y
Chen
M A
MA
Burton
J P
JP
Codde
S
S
Napoli
I J
IJ
Martins
B N
BN
Gray
D002851:Chromatography, High Pressure Liquid; D003432:Cross-Linking Reagents; D004317:Doxorubicin / Q000008:administration & dosage*; D004337:Drug Carriers; D004339:Drug Compounding; D006863:Hydrogen-Ion Concentration; D007474:Ion Exchange; D008863:Microspheres; D010316:Particle Size; D013056:Spectrophotometry, Ultraviolet
D003432:Cross-Linking Reagents; D004337:Drug Carriers; D004317:Doxorubicin