DNA polymorphisms associated with the factor VIII:C gene in the Portuguese population.
We have determined the allele frequencies of seven restriction fragment length polymorphisms within or close to factor VIII:C gene in the Portuguese population. The allele frequency of all studied intra- and extragenic biallelic polymorphisms does not differ significantly from those found in other European or Asian populations. On the contrary, the distribution of the different alleles of the TaqI RFLP at the DXS52 locus revealed similarity only with Algerians. We observed a correspondence between the TaqI and BclI alleles at this locus.
Laboratório de Genética Humana, Instituto Nacional de Saúde Dr Ricardo Jorge, Lisboa, Portugal.
D
D
David
C
C
Mergulhão
I
I
Capucho
J
J
Lavinha
D000462:Algeria; D000483:Alleles; D002681:China; D005006:Ethnicity / Q000235:genetics; D005169:Factor VIII / Q000235:genetics*; D005787:Gene Frequency; D006467:Hemophilia A / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D011174:Portugal
D005169:Factor VIII