Circulating ICAM-1 levels in serum of uveitis patients.
Intercellular Adhesion Molecule-1 (ICAM-1) is a cytokine-inducible adhesion molecule expressed on cells of multiple lineages at sites of inflammation. Recently a truncated form of ICAM-1 has been discovered to be circulating in serum. This study reports on circulating serum (cICAM-1) levels in 132 uveitis patients (HLA-B 27 pos. acute anterior uveitis (AAU); HLA-B27 neg. anterior uveitis (AU); intermediate uveitis (IU); heterochromic cyclitis Fuchs (HCF); sarcoidosis; Toxoplasmosis). Measurement of circulating ICAM-1 serum levels was performed using a monoclonal antibody based ELISA, with healthy blood donors serving as the control group. Applying multiple variance analysis and the Student Newmann-Keuls test we found a statistically significant elevation of serum cICAM-1 level in the HLA-B 27 neg. AU group (n:31), in the IU group (n:25) and in patients with sarcoidosis (n:18). Serum levels of HLA-B27 pos. AAU patients, patients with HCF and patients suffering from ocular toxoplasmosis did not differ significantly from levels of the control group.
Arocker-Mettinger
E
E
2nd Department of Ophthalmology, University of Vienna, Austria.
Steurer-Georgiew
L
L
Steurer
M
M
Huber-Spitzy
V
V
Hoelzl
E
E
Grabner
G
G
Kuchar
A
A
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000097:blood; D015815:Cell Adhesion Molecules / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005128:Eye Diseases / Q000097:blood; D005260:Female; D015796:HLA-B27 Antigen / Q000097:blood; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D015863:Iridocyclitis / Q000097:blood; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000097:blood; D014126:Toxoplasmosis, Ocular / Q000097:blood; D014605:Uveitis / Q000097:blood*; D014606:Uveitis, Anterior / Q000097:blood; D015867:Uveitis, Intermediate / Q000097:blood
D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D015796:HLA-B27 Antigen; D018799:Intercellular Adhesion Molecule-1