Inducible stable DNA replication in Escherichia coli uvr+ and uvr- cells, treated with genotoxic chemicals.
Inducible stable DNA replication (iSDR) provoked by a damaging treatment with MMS, MNU, MNNG, NFAA, NFN, 4NQO, NAL or MMC, was followed in both repair-competent E. coli PQ35 and its uvrA derivative E. coli PQ37. In contrast to SOS-inducible mutagenesis, which is more pronounced in excision-deficient cells, iSDR was more obvious in repair-competent cells. This may be due to special features of iSDR and need not indicate involvement of the uvrA gene product in it.
Masek
F
F
Department of Molecular Genetics, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
Sedliaková
M
M
D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology; D042462:4-Quinolones; D000179:Acrylates / Q000494:pharmacology; D000890:Anti-Infective Agents; D002701:Chloramphenicol / Q000494:pharmacology; D004261:DNA Replication / Q000187:drug effects*; D004926:Escherichia coli / Q000235:genetics*; D005663:Furans / Q000494:pharmacology; D008741:Methyl Methanesulfonate / Q000494:pharmacology; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D008770:Methylnitrosourea / Q000494:pharmacology; D016685:Mitomycin / Q000494:pharmacology; D009153:Mutagens / Q000494:pharmacology*; D009268:Nalidixic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D009574:Nitro Compounds / Q000494:pharmacology; D009581:Nitrofurans / Q000494:pharmacology
D042462:4-Quinolones; D000179:Acrylates; D000890:Anti-Infective Agents; D005663:Furans; D009153:Mutagens; D009574:Nitro Compounds; D009581:Nitrofurans; D008769:Methylnitronitrosoguanidine; D009268:Nalidixic Acid; C073116:5-nitro-2-furfuryl nitrate; D016685:Mitomycin; D015112:4-Nitroquinoline-1-oxide; C222012:nitrofurylacrylic acid; D002701:Chloramphenicol; D008770:Methylnitrosourea; C028959:citrated nalidixic acid; D008741:Methyl Methanesulfonate