[Multidrug resistance and the P-glycoprotein].
A survey is presented on the information concerning the nature and molecular mechanism of multi drug resistance, a phenomenon involving the resistance of tumor cells to different types of chemotherapeutic agents. P-glycoprotein is by its enzymatic activity directly responsible for expelling xenobiotics from the intracellular space and thus also for the development of MDR. Its detection provided new possibilities for causal studies of this type of resistance as well as for its in vitro modelling. In the presented survey, the function of P-glycoprotein is characterized also in cells of normal nontumorous tissue.
Ustav molekulárnej fyziológie a genetiky, SAV, Bratislave, CSFR.
L
L
Slosarcíková
A
A
Breier
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D004351:Drug Resistance / Q000502:physiology*; D006801:Humans; D008562:Membrane Glycoproteins / Q000032:analysis / Q000502:physiology*
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D008562:Membrane Glycoproteins
Multi drug resistance (MDR) a P-glykoprotein (P-gly).