The biology of hepatocyte growth factor/scatter factor.
Hepatocyte growth factor, a potent mitogen for epithelial and other cell types, and scatter factor, a stimulant of epithelial cell motility are identical. In addition to these mitogenic and motogenic functions, the factor has been shown to be an epithelial morphogen and also has antiproliferative effects in some cancer cell lines. The membrane receptor for hepatocyte growth factor/scatter factor has been identified as the c-met proto-oncogene product.
Furlong
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Department of Pathology, University of Cambridge, UK.
D000818:Animals; D002893:Chromosomes, Human, Pair 3; D002897:Chromosomes, Human, Pair 7; D005796:Genes; D017228:Hepatocyte Growth Factor / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008115:Liver Regeneration; D011487:Protein Conformation; D000090063:Proto-Oncogene Mas; D019859:Proto-Oncogene Proteins c-met; D051381:Rats; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology
C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D017228:Hepatocyte Growth Factor; D019859:Proto-Oncogene Proteins c-met; D020794:Receptor Protein-Tyrosine Kinases