Stimulation and inhibition of interferon-beta production of human diploid fibroblasts by foodstuffs.
We screened for foodstuffs affecting interferon-beta (IFN-beta) production of human foreskin diploid fibroblasts, in the presence of poly I.poly C, cycloheximide, and actinomycin D. alpha- and beta-caseins stimulated IFN-beta production dose-dependently, but kappa-casein inhibited it. Of the two chymosin fragments of kappa-casein, glycomacropeptide was an inhibitor but p-kappa-casein was not. beta-lactoglobulin stimulated IFN-beta production weakly, but lactoferrin inhibited it strongly. It was also shown that serum contained some factors inhibiting IFN-beta induction and stimulating its production.
Department of Food Science and Technology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.
K
K
Yamada
K
K
Matsumura
M
M
Suzaki
S
S
Shirahata
H
H
Murakami
D001769:Blood; D002364:Caseins / Q000494:pharmacology; D002478:Cells, Cultured; D003094:Collagen / Q000494:pharmacology; D003470:Culture Media; D004797:Enzyme-Linked Immunosorbent Assay; D004815:Epidermal Growth Factor / Q000494:pharmacology; D005347:Fibroblasts / Q000187:drug effects / Q000276:immunology*; D005502:Food; D006157:Guanosine Monophosphate / Q000494:pharmacology; D006801:Humans; D007370:Interferon Type I / Q000096:biosynthesis*; D007781:Lactoferrin / Q000494:pharmacology; D007782:Lactoglobulins / Q000494:pharmacology
D002364:Caseins; D003470:Culture Media; D007370:Interferon Type I; D007782:Lactoglobulins; D004815:Epidermal Growth Factor; D006157:Guanosine Monophosphate; D003094:Collagen; D007781:Lactoferrin