Increased circulating interleukin-1 and interleukin-6 after intracerebroventricular injection of lipopolysaccharide.
Recently, it was demonstrated that intracerebroventricular (icv) injection of interleukin-1 (IL-1) stimulated circulating interleukin-6 (IL-6) to a greater degree than intravenous (i.v.) injection of IL-1. The goal of this study was to compare the efficacy of lipopolysaccharide (LPS), injected both icv and i.v., on circulating concentrations of IL-1 and IL-6. Both i.v. and icv injection of LPS stimulated plasma levels of IL-1 to a similar degree. However, i.v. injection of LPS was significantly more efficacious than icv injection of LPS in elevating circulating IL-6. These results demonstrate that like i.v. injection of LPS, icv injection of LPS stimulates plasma levels of IL-1 and IL-6. Increases in circulating cytokines during infectious diseases which are limited to the central nervous system may serve to activate peripheral functions of an acute phase response.
US-Japan Biomedical Research Laboratories, Tulane University, Hebert Center, Belle Chasse, La 70037, USA.
P E
PE
Gottschall
G
G
Komaki
A
A
Arimura
D000818:Animals; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D007375:Interleukin-1 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000134:cerebrospinal fluid / Q000494:pharmacology*; D008297:Male; D011869:Radioligand Assay; D051381:Rats; D013997:Time Factors
D007375:Interleukin-1; D015850:Interleukin-6; D008070:Lipopolysaccharides