Subcellular compartmentation of 2'methyl MPP+ can explain differences in toxicity to adrenal chromaffin cells.
Division of Pharmacology, Wellcome Research Laboratories, Research Triangle Park, North Carolina 27709.
J F
JF
Reinhard
A J
AJ
Daniels
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology; D015655:1-Methyl-4-phenylpyridinium / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D000313:Adrenal Medulla / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D007700:Kinetics; D009498:Neurotoxins / Q000378:metabolism* / Q000494:pharmacology; D013347:Subcellular Fractions / Q000378:metabolism; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D009498:Neurotoxins; C075732:1-methyl-4-(2-methylphenyl)pyridinium; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D014446:Tyrosine 3-Monooxygenase; D015655:1-Methyl-4-phenylpyridinium