Common principles in protein folding and antigen presentation.
The regular recurrence of hydrophobic amino acid residues along a peptide sequence determines the formation of a longitudinal hydrophobic strip when the peptide forms an alpha-helix. An understanding of the ways this may affect both folding of nascent proteins and antigen presentation should facilitate vaccine and therapeutics design.
Department of Pharmacology, University of Massachusetts Medical School, Worcester 01655.
S
S
Lu
V E
VE
Reyes
R R
RR
Torgerson
R A
RA
Lew
R E
RE
Humphreys
D000595:Amino Acid Sequence; D000941:Antigens / Q000276:immunology; D016384:Consensus Sequence; D000939:Epitopes / Q000276:immunology; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D000941:Antigens; D000939:Epitopes; D011506:Proteins