[The effect of dopamine receptor stimulation on the motor and stereotypic activities of mice with different genotypes].
On mice of 8 highly inbred strains--BALB/c, DBA/2, C57B1/6, CBA, DD, CC57Br, C3H/He, A/He--the role was studied of dopamine receptors of the first and second types (D1 and D2) in the regulation of the general motor activity and stereotypic climbing. Significant dependence was shown of these types of dopamine-dependent behaviour on the genotype. Agonist of D1/D2 receptors, apomorphine decreased the motor activity of animals of the all studied strains, and this effect significantly depended on the genotype. The inhibition of locomotion after selective stimulation of D2 receptors (by LY 171555) was significant. Distribution of mouse strains according to expressiveness of climbing after administration of apomorphine differed from their distribution by the level of motor activity. Selective stimulation of D1 receptors, on the whole, elicited climbing of lesser intensity than D1/D2 activation (excluding CBA strain), and administration of D2 agonist did not induce it at all. Probably, for full expression of behavioural reactions the interaction between D1 and D2 receptors is required.
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D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D015259:Dopamine Agents / Q000494:pharmacology; D004873:Ergolines / Q000494:pharmacology; D005824:Genetics, Behavioral; D005838:Genotype; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000502:physiology*; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D019257:Quinpirole; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000502:physiology; D013239:Stereotyped Behavior / Q000187:drug effects* / Q000502:physiology; D013268:Stimulation, Chemical
D015259:Dopamine Agents; D004873:Ergolines; D011954:Receptors, Dopamine; D019257:Quinpirole; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D001058:Apomorphine
Vliianie stimuliatsii dofaminovykh retseptorov na dvigatel'nuiu i stereotipnuiu aktivnost' mysheĭ razlichnykh genotipov.