[Somatostatin as a modulator of vagal effects on heart rhythm].
In 11 experiments on anesthetised cats burst stimulation of peripheral cut end of right vagus nerve leads to synchronization of cardiac and vagus rhythms. Alterations of burst sequence frequency within definite limits has been synchronously reproduced by heart thus creating managed bradycardia possibility. Somatostatin (10(-8)-10(-9) M intravenously) decreases heart rate and inhibits total vagus chronotropic effect. Vagolytic effect of somatostatin caused a decrease of tonic component of the vagus chronotropic effect. On the other hand, somatostatin augmented the extent of the vagal synchronizing influences and caused enlargement of the ranges of managed bradycardia. The observed results testify to participation of the peptidergic mechanisms in genesis of vagal managed bradycardia.
Pokrovskiĭ
V M
VM
Osadchiĭ
O E
OE
Kurzanov
A N
AN
D000818:Animals; D001919:Bradycardia / Q000209:etiology; D002415:Cats; D004558:Electric Stimulation; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D013004:Somatostatin / Q000494:pharmacology / Q000502:physiology*; D014630:Vagus Nerve / Q000187:drug effects / Q000502:physiology*
D013004:Somatostatin
Somatostatin kak moduliator vagusnogo vliianiia na ritm serdtsa.