[Investigation of the therapeutic use of proton pump inhibitor (PPI) by measurement of 24 hour the intra-gastric pH].
The intragastric acidic condition were examined over 24 hours in 13 healthy volunteers to compare the inhibitory effect of PPI and of H2-antagonist on the acid secretion. Both PPI 15 mg and PPI 20 mg showed a stronger action on the acid inhibition than H2-antagonists. The morning PPI (20 mg) administration inhibited the acid secretion from noon the first day, and showed an even stronger effect on the fourth day (total PPI 80 mg). Evening PPI administration showed poorer effects than the morning. However, of this was due to a difference in the inhibitory effect in the daytime. The evening PPI administration showed effective acid inhibition at night, and nocturnal intra-gastric pH inversion appeared. It is suggested that the evening PPI administration is more suitable both the ulcer-healing and food digestion in the curative stage.
Department of Internal Medicine, University of Tsukuba.
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Yamagata
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000328:Adult; D002940:Circadian Rhythm; D003864:Depression, Chemical; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D017506:H(+)-K(+)-Exchanging ATPase; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008991:Monitoring, Physiologic; D009853:Omeprazole / Q000008:administration & dosage* / Q000494:pharmacology
D006635:Histamine H2 Antagonists; D000251:Adenosine Triphosphatases; D017506:H(+)-K(+)-Exchanging ATPase; D009853:Omeprazole