Variations of plasma creatine kinase in rabbits following repetitive blood sampling effects of pretreatment with acepromazine, carazolol and dantrolene.
Plasma creatine kinase activity increased significantly (P less than 0.001) in rabbits sampled every two hours for 12 hours (mean from 509 to 2242 U/l), but did not change when rabbits had been accustomed to laboratory handling procedures for two weeks. This increase was not alleviated or only moderately by pretreatment with acepromazine (per os, 2.5 mg.kg-1), carazolol (intravenously, 0.05 mg.kg-1) or dantrolene (intravenously, 1.0 mg.kg-1). Thus, when using plasma creatine kinase in rabbits, e.g. to test muscle damage or local tolerance of drugs, animals should be made familiar with laboratory procedures before any experiment.
Département de Physiopathologie, Ecole Nationale Vétérinaire, Toulouse, France.
H P
HP
Lefebvre
J P
JP
Jaeg
A G
AG
Rico
P L
PL
Toutain
J P
JP
Braun
D000075:Acepromazine / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001800:Blood Specimen Collection; D003402:Creatine Kinase / Q000097:blood*; D003620:Dantrolene / Q000494:pharmacology*; D004924:Escape Reaction / Q000187:drug effects; D005260:Female; D009043:Motor Activity / Q000187:drug effects; D009132:Muscles / Q000187:drug effects; D011412:Propanolamines / Q000494:pharmacology*; D011817:Rabbits
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; C014382:carazolol; D000075:Acepromazine; D003402:Creatine Kinase; D003620:Dantrolene