The effect of tequila in the synaptonemal complex structure of mouse spermatocytes.
The effect of tequila in the synaptonemal complex (SC) of mouse spermatocytes was determined. We tested 3 dosages (2.1, 4.2 and 8.4 g/kg) administered in a single intraperitoneal inoculation. The frequency of SC alterations was established in pachytenic nuclei 5 days after the administration using a silver impregnation technique. Three types of alterations were observed (desynapses, breaks and multiaxials) and the rate of each alteration was compared with that obtained with appropriate controls, including cyclophosphamide (CP) (150 mg/kg). The results showed a significant increase induced by tequila only in the frequency of desynapses. This damage began at the second highest dose (4.2 g/kg). The other SC alterations were in the control range. CP, however, induced a significant increase in all 3 types of SC alterations.
Tapia
F
F
Laboratorio de Genética, Depto. de Morfología, Escuela Nacional de Ciencias Biológicas, Tomás, Mexico, DF.
Madrigal-Bujaidar
E
E
Aguirre
S
S
D000434:Alcoholic Beverages / Q000633:toxicity*; D000818:Animals; D008297:Male; D051379:Mice; D013090:Spermatocytes / Q000187:drug effects*; D013573:Synaptonemal Complex / Q000187:drug effects*