A comparison of esmolol and labetalol for the treatment of perioperative hypertension in geriatric ambulatory surgical patients.
This is an open randomized study comparing the efficacy and safety of i.v. esmolol and labetalol in the treatment of perioperative hypertension in ambulatory surgery. Twenty-two elderly patients undergoing cataract surgery under local anaesthesia were studied. The main inclusion criteria were development of systolic blood pressure greater than 200 mmHg or diastolic greater than 100 mmHg. Esmolol was given as a bolus 500 micrograms.kg-1 i.v. followed by a maintenance infusion (150-300 micrograms.kg-1.min-1). Labetalol was given as a bolus of 5 mg i.v. followed by 5 mg increments as needed up to a maximum of 1 mg.kg-1. Esmolol and labetalol both produced reductions in systolic and diastolic blood pressure (P less than 0.05) within ten minutes of administration which lasted for at least two hours. Reduction of blood pressure by esmolol was accompanied by a decrease in HR (P less than 0.05). Two patients developed extreme bradycardia (HR less than 50 beats.min-1) and esmolol had to be discontinued. Labetalol, in contrast, induced only a moderate decrease in HR. None of the patients treated with labetalol experienced any prolonged side effects such as orthostatic hypotension. In conclusion, esmolol may produce considerable bradycardia in elderly patients when hypertension is not accompanied by tachycardia. Labetalol was easier to administer in the ambulatory setting and one-tenth the cost of esmolol.
Department of Anesthesiology, Mount Sinai School of Medicine, New York, NY.
P P
PP
Singh
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I
Dimich
I
I
Sampson
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N
Sonnenklar
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000368:Aged; D000369:Aged, 80 and over; D000556:Ambulatory Surgical Procedures; D000704:Analysis of Variance; D001794:Blood Pressure / Q000187:drug effects; D002387:Cataract Extraction; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007275:Injections, Intravenous; D007431:Intraoperative Complications / Q000188:drug therapy*; D007741:Labetalol / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D015999:Multivariate Analysis; D011187:Posture; D011412:Propanolamines / Q000008:administration & dosage / Q000627:therapeutic use*; D016683:Supine Position; D013599:Systole; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; C036604:esmolol; D007741:Labetalol