[Main drug interactions at a hospital emergency department. Analysis of 100 cases].
We prospectively reviewed clinical charts of 100 consecutive patients that were admitted during the first trimester 1991 to the Emergency Department of a general hospital in order to determine the more frequent prescribed drugs and their interactions using a computer program (Drug Interaction Program), emphasizing in those drugs used to treat peptic ulcers. Number of drugs prescribed to each patient was 4.20 +/- 1.39. Antacids (39%) and cimetidine (35%) occupied the third and fourth place. There were interactions in 79 patients and in 66 of them (84%) they were important. Antacid and cimetidine were similarly prescribed, but of 35 patients who received cimetidine only 3 (8.5%) had a primary indication for its use (Gastrointestinal bleeding). Significant clinical interactions of cimetidine with other medications are analyzed. Our results indicate that drug interactions are a permanent risk in our hospitals. We suggest to use a computer program on drug interactions or an updated chart of medications in the emergency rooms of our hospitals.
Departamento de Medicina, Universidad de Carabobo.
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Martí
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de Kolster
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Kolster
D000293:Adolescent; D000328:Adult; D000368:Aged; D000863:Antacids / Q000009:adverse effects; D002927:Cimetidine / Q000009:adverse effects; D004347:Drug Interactions; D016903:Drug Monitoring; D004630:Emergencies; D005260:Female; D006635:Histamine H2 Antagonists / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D000863:Antacids; D006635:Histamine H2 Antagonists; D002927:Cimetidine
Principales interacciones medicamentosas en una emergencia hospitalaria. Analysis de 100 casos.