Simultaneous occurrence of monoclonal gammopathy and acute secondary leukemia with overexpression of P-glycoprotein.
A 52-year-old woman, previously treated with chemo- and radiotherapy for Hodgkin's disease, developed an acute non-lymphoid leukemia and, contemporarily, an IgG-kappa paraproteinemia. Cytogenetic analysis showed a major clone, representing 90% of observed metaphases, with monosomy of chromosomes 5 and 14. In addition, leukemic cells exhibited a high expression of the P-glycoprotein, a transmembrane glycoprotein involved in the multidrug-resistance mechanism. Possible explanations for this cluster of findings are provided.
Stasi
R
R
Division of Hematology, II University of Rome Tor Vergata, Italy.
Tribalto
M
M
Venditti
A
A
del Poeta
G
G
Aronica
G
G
Zaccar
G
G
Rossi
V
V
Maffei
L
L
Papa
G
G
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000328:Adult; D003131:Combined Modality Therapy / Q000009:adverse effects; D005260:Female; D006689:Hodgkin Disease / Q000628:therapy*; D006801:Humans; D007145:Immunoglobulin kappa-Chains; D016130:Immunophenotyping; D015470:Leukemia, Myeloid, Acute / Q000209:etiology* / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000209:etiology; D009363:Neoplasm Proteins / Q000378:metabolism; D016609:Neoplasms, Second Primary / Q000209:etiology* / Q000378:metabolism; D010265:Paraproteinemias / Q000209:etiology* / Q000378:metabolism
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D007145:Immunoglobulin kappa-Chains; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins