Expression of the high affinity IgE-receptor on human Langerhans' cells. Elucidating the role of epidermal IgE in atopic eczema.
Epidermal Langerhans' cells have previously been shown to bear IgE molecules, particularly in atopic dermatitis skin. Using two highly specific antibodies against the antibody-binding chain of the high affinity IgE-receptor, 29C6 and 6F7, we here provide evidence that Langerhans' cells express this receptor in both normal skin (foreskin) and in lesional skin of patients with atopic and stasis eczema. A specific antibody against the low affinity IgE-receptor, Tü1, showed only a low expression of this receptor. This finding has important potential functional implications for the role of Langerhans' cells in transepidermal, IgE-mediated allergy.
Haas
N
N
Department of Dermatology, Rudolf Virchow Hospital, Free University of Berlin, Germany.
Hamann
K
K
Grabbe
J
J
Cremer
B
B
Czarnetzki
B M
BM
D000915:Antibody Affinity / Q000276:immunology*; D002452:Cell Count; D003713:Dendritic Cells; D003876:Dermatitis, Atopic / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D007801:Langerhans Cells / Q000276:immunology*; D008297:Male; D008407:Mast Cells / Q000276:immunology; D017455:Receptors, IgE / Q000032:analysis*; D012867:Skin / Q000276:immunology* / Q000473:pathology
D017455:Receptors, IgE; D007073:Immunoglobulin E