[Level of erythropoietin and parathormone in blood plasma during acute rejection of kidney transplant].
The acute rejection of kidney transplant is accompanied by kidney ischaemia which in turn is a triggering factor for erythropoietin (EPO) synthesis. It was shown, on the other hand, that during the rejection an increase in blood serum parathormone (PTH) concentration takes place. The present study was aimed at answering the question what is the effect of acute rejection of kidney transplant on blood serum concentrations of EPO i PTH. Seventeen patients with kidney transplant participated in the study. In all the patients the investigations were carried out four times: 1--few days before rejection, 2--after ascertaining that kidney transplant is being rejected, 3--immediately after rejection, and 4--few days after completing the anti-rejection therapy. High doses of methylprednisolone were used as anti-rejection therapy. Control group consisted of 16 healthy persons. Acute rejection of kidney transplant was accompanied by a significant increase in blood serum concentrations of EPO and PTH. After methylprednisolone therapy, normalization of EPO and decrease in PTH concentration were observed in kidney transplant patients. Significant positive correlations were found between EPO and PTH concentrations in blood serum. It was concluded that acute rejection of kidney transplant is characterized by a significant increase in blood serum concentrations of EPO and PTH. Despite the existence of a significant positive correlation between blood serum concentrations of EPO and PTH in patients with kidney transplant, any pathogenic relation between the observed disturbances of secretion of the two hormones seems to be of little probability.
Kokot
F
F
Katedra i Klinika Nefrologii Slaskiej AM, Katowicach.
Grzeszczak
W
W
Wiecek
A
A
Lao
M
M
Gradowska
L
L
Jagiełło
R
R
Wnuk
A
A
D000208:Acute Disease; D000328:Adult; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D006084:Graft Rejection / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*
D010281:Parathyroid Hormone; D004921:Erythropoietin; D008775:Methylprednisolone
Stezenie erytropoetyny i parathormonu w osoczu krwi w okresie ostrego odrzucania przeszczepionej nerki.