A comparison of ovulation suppression and ovulation stimulation in the treatment of endometriosis-associated infertility.
This study compares ovulation stimulation or suppression with the pregnancy rate among infertile couples with endometriosis. The design is a nonrandomized, prospective, multicentered cohort analytic study. Two hundred and ninety-seven couples with laparoscopy-proven endometriosis were analyzed: 68 received no therapy, 42 received clomiphene and 74 received danazol. Forty patients (22%) conceived and pregnancy rates were similar in each treatment group. The relative likelihood of pregnancy associated with clomiphene was 2.9 (95% confidence limits 1.2-7.1); the relative likelihood of pregnancy with danazol was 1.02 (95% confidence limits 0.5-2.3). This study suggests that pregnancy rates during clomiphene treatment could be superior to expectant therapy, while pregnancy rate after danazol is similar to no treatment.
Simpson
C W
CW
Department of Obstetrics and Gynecology, University of Saskatchewan, Saskatoon, Canada.
Taylor
P J
PJ
Collins
J A
JA
D000328:Adult; D002996:Clomiphene / Q000494:pharmacology / Q000627:therapeutic use*; D015331:Cohort Studies; D003613:Danazol / Q000494:pharmacology / Q000627:therapeutic use*; D004715:Endometriosis / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D010062:Ovulation Induction; D011247:Pregnancy; D016016:Proportional Hazards Models; D011446:Prospective Studies; D014594:Uterine Neoplasms / Q000150:complications* / Q000188:drug therapy
D002996:Clomiphene; D003613:Danazol