Resistance of hippocampal CA-1 noradrenergic fibers to five minutes of transient cerebral ischemia in the gerbil.
We examined changes in the tyrosine hydroxylase (TH)-immunoreactive fibers following 5 min of cerebral ischemia in gerbils using an immunohistochemical method 1, 3 and 30 days after ischemia. Almost all CA-1 pyramidal neurons were lost 3 days after ischemia, whereas noradrenergic fibers were maintained 30 days after ischemia. The present study demonstrated that TH-immunoreactive fibers and cells were resistant to transient ischemia, and that there was no sprouting or hyperactivity in noradrenergic systems after ischemia.
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
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Tomioka
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Nishioka
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Kogure
D000320:Adrenergic Fibers / Q000502:physiology*; D000818:Animals; D004299:Dopamine beta-Hydroxylase / Q000276:immunology / Q000378:metabolism; D005849:Gerbillinae; D006624:Hippocampus / Q000473:pathology*; D007150:Immunohistochemistry; D002546:Ischemic Attack, Transient / Q000473:pathology*; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D011712:Pyramidal Tracts / Q000473:pathology; D014446:Tyrosine 3-Monooxygenase / Q000276:immunology / Q000378:metabolism
D014446:Tyrosine 3-Monooxygenase; D004299:Dopamine beta-Hydroxylase; D009638:Norepinephrine