Dehydroepiandrosterone as predictor for progression to AIDS in asymptomatic human immunodeficiency virus-infected men.
The steroid hormone dehydroepiandrosterone (DHEA) has been reported to protect against certain viral infections in animal models and to be a modest inhibitor of human immunodeficiency virus type 1 (HIV-1) infection in vitro. Serum DHEA levels were determined in 41 asymptomatic HIV-1-seropositive subjects, who progressed to AIDS within 5 years after entering a cohort study, in 41 HIV-1-seropositive controls, who remained asymptomatic, and in 41 HIV-1-seronegative controls. At entry, DHEA levels were higher in the seronegative group (median, 13.3 nmol/l) than in either the seropositive nonprogressors (median, 9.2 nmol/l; P = .01) or the progressors (median, 7.2 nmol/l; P less than .001). DHEA levels in the progressors approximately 5 months before the diagnosis of AIDS were lower than the levels in the nonprogressors after the same follow-up (median, 5.6 vs. 8.8 nmol/l; P = .007). DHEA levels less than 7 nmol/l and CD4+ cell counts less than 0.5 x 10(9)/l both proved to be independent predictors for disease progression in HIV-1-infected men.
Mulder
J W
JW
Department of Infectious Diseases, University of Amsterdam, Netherlands.
Frissen
P H
PH
Krijnen
P
P
Endert
E
E
de Wolf
F
F
Goudsmit
J
J
Masterson
J G
JG
Lange
J M
JM
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000175:diagnosis*; D015496:CD4-Positive T-Lymphocytes; D016022:Case-Control Studies; D015331:Cohort Studies; D003687:Dehydroepiandrosterone / Q000097:blood*; D016655:HIV Core Protein p24 / Q000097:blood; D006679:HIV Seropositivity / Q000097:blood*; D006716:Homosexuality; D006801:Humans; D007958:Leukocyte Count; D008137:Longitudinal Studies; D008297:Male; D011446:Prospective Studies; D012044:Regression Analysis; D001613:beta 2-Microglobulin / Q000032:analysis
D016655:HIV Core Protein p24; D001613:beta 2-Microglobulin; D003687:Dehydroepiandrosterone