Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice.
Injection of mice transgenic for a class I major histocompatibility complex-restricted T-cell receptor with a soluble peptide antigen from influenza virus nucleoprotein results in clonal depletion of double-positive immature thymocytes in the thymus and activation of mature T cells in the periphery, accompanied by a transient up-regulation of the T-cell receptor and CD3 and CD8 coreceptor molecules.
Laboratory of Molecular Immunology, National Institute for Medical Research, Mill Hill, London, United Kingdom.
C
C
Mamalaki
T
T
Norton
Y
Y
Tanaka
A R
AR
Townsend
P
P
Chandler
E
E
Simpson
D
D
Kioussis
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D017252:CD3 Complex / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016827:CD8 Antigens / Q000032:analysis; D015870:Gene Expression; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D008198:Lymph Nodes / Q000166:cytology; D008213:Lymphocyte Activation; D051379:Mice; D008822:Mice, Transgenic; D019590:Nucleocapsid Proteins; D009698:Nucleoproteins; D009975:Orthomyxoviridae / Q000276:immunology; D010455:Peptides / Q000737:chemistry / Q000276:immunology; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*; D012995:Solubility; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology*; D014758:Viral Core Proteins / Q000276:immunology*
D000956:Antigens, Viral; D017252:CD3 Complex; D016827:CD8 Antigens; D015395:Histocompatibility Antigens Class I; D019590:Nucleocapsid Proteins; D009698:Nucleoproteins; D010455:Peptides; D016693:Receptors, Antigen, T-Cell, alpha-beta; D014758:Viral Core Proteins