Abnormal expression of Ki-67 antigen in hair follicle of alopecia areata.
The monoclonal antibody Ki-67 was used to determine the numbers of cycling cells in hair follicles both in alopecia areata and in normal scalp skin. Pronounced nuclear staining was limited to the area below the critical line of Auber and the exterior part of the outer root sheath. In alopecia areata there is reduced nuclear Ki-67 binding in the bulb of anagen hair follicles. These findings indicate that inhibition of keratinocyte proliferation might be a pathogenetic mechanism in alopecia areata.
Department of Dermatology, University Nijmegen, The Netherlands.
H M
HM
van Baar
C M
CM
Perret
I M
IM
van Vlijmen
P C
PC
van de Kerkhof
R
R
Happle
J
J
Schalkwijk
D000506:Alopecia Areata / Q000276:immunology / Q000473:pathology*; D000911:Antibodies, Monoclonal; D000941:Antigens / Q000032:analysis; D002455:Cell Division; D002467:Cell Nucleus / Q000276:immunology; D006197:Hair / Q000276:immunology / Q000473:pathology*; D006801:Humans; D015603:Keratinocytes / Q000276:immunology / Q000473:pathology*
D000911:Antibodies, Monoclonal; D000941:Antigens