Metal-binding sites in proteins.
A dramatic increase in the number of solved metalloprotein structures and recent breakthroughs in structural analysis have provided a sufficiently detailed understanding of the structural chemistry of some metal-binding sites to allow successful design. As a result, metal-binding site design is now one of the most powerful and promising approaches for influencing protein folding, assembly, stability and catalysis.
Tainer
J A
JA
Department of Molecular Biology, Scripps Research Institute, La Jolla, California 92037.
Roberts
V A
VA
Getzoff
E D
ED
D000595:Amino Acid Sequence; D001665:Binding Sites; D008667:Metalloproteins / Q000737:chemistry*; D008670:Metals / Q000737:chemistry; D008958:Models, Molecular; D008969:Molecular Sequence Data; D015202:Protein Engineering
D008667:Metalloproteins; D008670:Metals