Studies and perspectives of signal transduction in the skin.
Tumor-promoting phorbol ester and epidermal growth factor (EGF) exert marked influences on the proliferation and differentiation of keratinocytes. These two agents bring their physiological functions into play via protein kinase C (PKC) activation (and/or down regulation) and protein tyrosine kinase, respectively. In this paper, the present situation in the studies on the signal transduction of keratinocytes centering around these two kinases is discussed. An outline of studies on signal transduction of cells other than keratinocytes in the skin is also given.
Department of Dermatology, Hyogo College of Medicine, Japan.
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Inohara
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002450:Cell Communication; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D015398:Signal Transduction; D012867:Skin / Q000166:cytology / Q000378:metabolism*; D012878:Skin Neoplasms / Q000139:chemically induced; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D015127:9,10-Dimethyl-1,2-benzanthracene; D011505:Protein-Tyrosine Kinases; D011493:Protein Kinase C; D013755:Tetradecanoylphorbol Acetate