Effects of temperature on the anaesthetic potency of halothane, enflurane and ethanol in Daphnia magna (Cladocera: Crustacea).
1. The effects of temperature on the anesthetic potencies of halothane, enflurane and ethanol have been studied in the water flea Daphnia magna. 2. In the absence of anaesthetics, decreasing temperature resulted in decreased activity by the daphnids. 3. Potencies in the gas phase decreased with increasing temperature for all of the anaesthetics, while aqueous potency decreased for halothane and enflurane but increased for ethanol. 4. Enthalpy calculations suggest that the observed potency changes for the inhalational anaesthetics cannot be accounted for in terms of changing solubility in lipid bilayers but most likely reflect more specific interactions with animal target sites.
McKenzie
J D
JD
Department of Animal and Plant Sciences, University of Sheffield, U.K.
Calow
P
P
Clyde
J
J
Miles
A
A
Dickinson
R
R
Lieb
W R
WR
Franks
N P
NP
D000818:Animals; D003621:Daphnia / Q000187:drug effects*; D004737:Enflurane / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D006221:Halothane / Q000494:pharmacology*; D007700:Kinetics; D013696:Temperature; D013816:Thermodynamics
D000431:Ethanol; D004737:Enflurane; D006221:Halothane