Soluble receptors for IL-1 and IL-4: biological activity and therapeutic potential.
Cytokine research has yielded a range of products which have now reached the stage of clinical trials and a plethora of novel therapeutics may be expected. Recently, cytokine receptors have also become an area of intensive research. Preliminary results indicate that recombinant soluble receptors can interfere with the biological functions of cytokines and thus may be appropriate for the treatment of certain pathological conditions where cytokine activity needs to be modulated.
Immunex Corporation, Seattle, WA 98101.
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Maliszewski
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Fanslow
D000818:Animals; D016207:Cytokines / Q000037:antagonists & inhibitors; D006084:Graft Rejection; D006801:Humans; D007109:Immunity; D008213:Lymphocyte Activation / Q000276:immunology; D011971:Receptors, Immunologic / Q000494:pharmacology* / Q000627:therapeutic use; D017472:Receptors, Interleukin-1; D019948:Receptors, Interleukin-4; D011975:Receptors, Mitogen / Q000494:pharmacology* / Q000627:therapeutic use; D011994:Recombinant Proteins; D012995:Solubility
D016207:Cytokines; D011971:Receptors, Immunologic; D017472:Receptors, Interleukin-1; D019948:Receptors, Interleukin-4; D011975:Receptors, Mitogen; D011994:Recombinant Proteins