Elevated IgG anti-histone antibodies in a subgroup of medicated schizophrenic patients.
A total of 57 schizophrenic patients (of which 17 were first-episode, neuroleptic naive) and 76 healthy controls were screened for anti-histone IgG antibodies using an enzyme immunoassay (ELISA). All patients had significantly higher anti-histone antibody titers than controls (t = 3.1, p less than 0.003). Previously medicated patients had significantly higher titers than neuroleptic-naive first episode patients (t = 2.87, p less than 0.006). This study suggests that neuroleptic medications are associated with anti-histone antibodies.
Chengappa
K N
KN
Department of Psychiatry, Western Psychiatric Institute & Clinic, Pittsburgh, PA 15213-2593.
Carpenter
A B
AB
Yang
Z W
ZW
Brar
J S
JS
Rabin
B S
BS
Ganguli
R
R
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001323:Autoantibodies / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006657:Histones / Q000276:immunology*; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000188:drug therapy / Q000276:immunology*; D012565:Schizophrenic Psychology
D014150:Antipsychotic Agents; D001323:Autoantibodies; D006657:Histones