Anonymous markers located on chromosome 6 in the HLA-A class I region: allelic distribution in genetic haemochromatosis.
Two yeast artificial chromosomes of the HLA class I region were subcloned. Four of the subclones studied displayed restriction polymorphisms that corresponded to six bi-allelic series. Allelic distribution of the anonymous markers was then studied by comparing a control population with a group of patients with familial haemochromatosis. Only one marker presents an unequivocal association with the haemochromatosis gene and is 100 kb centromeric to HLA-A. This association however is not as strong as with HLA-A3. The results suggest two possible locations for the haemochromatosis gene: less than 100 kb centromeric to the HLA-A locus, or on the telomeric side.
Boretto
J
J
Centre d'Immunologie INSERM-CNRS, Marseille, France.
Jouanolle
A M
AM
Yaouanq
J
J
el Kahloun
A
A
Mauvieux
V
V
Blayau
M
M
Perichon
M
M
Le Treut
A
A
Clayton
J
J
Borot
N
N
D000483:Alleles; D002896:Chromosomes, Human, Pair 6; D015342:DNA Probes / Q000235:genetics; D005805:Genes, MHC Class I; D005819:Genetic Markers / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics*; D006432:Hemochromatosis / Q000235:genetics*; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length
D015342:DNA Probes; D005819:Genetic Markers; D015234:HLA-A Antigens