Comparative study of the H2-receptor antagonists cimetidine, ranitidine, famotidine and nizatidine on the rabbit stomach fundus and sigmoid colon.
The H2-receptor antagonists, cimetidine, ranitidine, famotidine and nizatidine, were tested for their effect on the isolated smooth muscle strips from the rabbit stomach fundus and sigmoid colon. These H2-receptor antagonists were found to possess a concentration-dependent contractile effect on the above smooth muscle preparations and the order of potency was: ranitidine = nizatidine > famotidine > cimetidine. In addition, the smooth muscle preparations from the sigmoid colon were significantly more sensitive to the above compounds than the smooth muscle preparations from the stomach fundus.
Kounenis
G
G
Department of Pharmacology, Faculty of Veterinary Medicine, Aristotelian University, Thessaloniki, Greece.
Koutsoviti-Papadopoulou
M
M
Elezoglou
A
A
Voutsas
A
A
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002927:Cimetidine / Q000494:pharmacology; D012809:Colon, Sigmoid / Q000187:drug effects; D015738:Famotidine / Q000494:pharmacology; D005260:Female; D005748:Gastric Fundus / Q000187:drug effects; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D016567:Nizatidine / Q000494:pharmacology; D011817:Rabbits; D011899:Ranitidine / Q000494:pharmacology
D006635:Histamine H2 Antagonists; D015738:Famotidine; D002927:Cimetidine; D011899:Ranitidine; D000109:Acetylcholine; D016567:Nizatidine