Altered glucose metabolism in adriamycin-induced heart failure.
Spontaneously hypertensive rats received 1 mg/kg of Adriamycin intravenously once a week for up to 12 weeks; their hearts were excised and perfused with buffer containing 5 mM [1-13C]glucose. Histological evidence of Adriamycin cardiotoxicity was evident after 8 and 12 weeks of treatment and was accompanied by a significant decrease in cardiac function. There were only minor changes in the 31P-NMR spectra in hearts following treatment; however, 13C-NMR spectra revealed decreased incorporation of label into the lactate, alanine and glutamate pools in hearts with severe tissue damage compared to hearts from untreated animals.
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
J C
JC
Chatham
G M
GM
Hutchins
J D
JD
Glickson
D000409:Alanine / Q000378:metabolism; D000818:Animals; D004317:Doxorubicin / Q000633:toxicity*; D005947:Glucose / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D006321:Heart / Q000187:drug effects*; D006331:Heart Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D051381:Rats; D011918:Rats, Inbred SHR
D005971:Glutamates; D007773:Lactates; D019344:Lactic Acid; D018698:Glutamic Acid; D004317:Doxorubicin; D005947:Glucose; D000409:Alanine