[Effects of beta blocking agent iontophoresis by modulated sinusoidal current].
The action of the transcutaneous application of propranolol using modulated sinusoidal current iontophoresis was studied. When this way of administration is used, the drug, while maintaining its negative chronotropic effect, loses the negative inotropic one. Investigations were performed on 58 men aged 32 to 62 who underwent an aortocoronary bypass for myocardial ischemia. Thirty-four patients had already had myocardial infarction. The drug reduced the heart rate and increased cardiac contractility. Moreover, the study showed that only the levogyral isomer of propranolol (the only active one) passes through the skin.
Ghighineishvili
G R
GR
Centro Scientifico Pansovietico di Riabilitazione e Terapia Fisica, Università degli Studi di Milano.
Balsamo
V
V
Sirtori
P G
PG
Miani
A
A
Lanfranchi
M
M
Dagnoni
L
L
Mauro
F
F
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000328:Adult; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000601:surgery; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007478:Iontophoresis; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D011182:Postoperative Care; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D011433:Propranolol
Effetti della ionoforesi con beta-bloccanti con corrente sinusoidale modulata.