Role of Ca2+ channel blockers in insulin secretion resulting from alpha 1- and beta-adrenoceptor stimulation in the rabbit.
In conscious fasted rabbits the i.v. infusion of amidephrine (alpha 1-agonist) or isoprenaline (beta-agonist) induced an increase in plasma levels of immunoreactive insulin. The alpha 1-mediated response was suppressed in animals pretreated with calcium channel blockers (verapamil and elgodipine). The potentiated insulin secretory response in rabbits exposed to dual (alpha 1 + beta) adrenoceptor stimulation was also prevented by verapamil and elgodipine. These results suggest that extracellular calcium is required to mediate the effects of amidephrine on insulin secretion and to support potentiation.
Department of Pharmacology, School of Medicine, University of Salamanca, Spain.
M J
MJ
García-Barrado
M
M
Reverte
J
J
Moratinos
D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D000318:Adrenergic beta-Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000494:pharmacology*; D007262:Infusions, Intravenous; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D011817:Rabbits
D000316:Adrenergic alpha-Agonists; D000318:Adrenergic beta-Agonists; D001786:Blood Glucose; D002121:Calcium Channel Blockers; D007328:Insulin