Virulence factors in Escherichia coli from urinary tract infections in patients with spinal injuries.
A collection of 70 strains of Escherichia coli from urinary tract infections in spine-injured patients undergoing long-term bladder catheterization were tested for characteristics that have been associated with the ability to produce pyelonephritis. The incidence of the virulence factors were: mannose-resistant haemagglutinins (30%), P-fimbriae (17%), haemolysin (27%), K-antigens (28%) and aerobactin (by bioassay 33%, by gene probe 39%). Only 54% of the strains belonged to the O-serotypes usually associated with urinary tract infections. E. coli carrying the full complement of virulence factors were rare in the urinary tract of the spinal patients and were not associated with episodes of symptomatic pyelonephritis. It is clear that the neuropathic bladder and the presence of the catheter permits a wide variety of bacterial types to colonize the urinary tract and cause infection of the kidney. The identification of host markers rather than bacterial factors is suggested as a more fruitful approach to the early detection of cases likely to progress to pyelonephritis in this group of patients.
School of Pure and Applied Biology, University of Wales College of Cardiff, UK.
J
J
Benton
J
J
Chawla
S
S
Parry
D
D
Stickler
D003428:Cross Infection / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology*; D004926:Escherichia coli / Q000145:classification* / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology*; D006801:Humans; D015994:Incidence; D015995:Prevalence; D011446:Prospective Studies; D011704:Pyelonephritis / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology*; D012307:Risk Factors; D012703:Serotyping; D013119:Spinal Cord Injuries / Q000150:complications*; D001750:Urinary Bladder, Neurogenic / Q000150:complications* / Q000628:therapy; D014546:Urinary Catheterization / Q000009:adverse effects; D014852:Wales / Q000453:epidemiology