Merkel cell carcinoma with pagetoid spread.
A case of Merkel cell carcinoma showing epidermotropism is presented. The neoplastic cells displayed dotlike immunoreactivity for cytokeratins and strong immunoreactivity for neuron-specific enolase. Although no neuroendocrine granules were found, characteristic paranuclear fibrous bodies were present.
Department of Pathology, Scott and White Clinic, Texas A&M University School of Medicine, Temple 76508.
L R
LR
Donner
V O
VO
Speights
R A
RA
Trompler
D000368:Aged; D015266:Carcinoma, Merkel Cell / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008297:Male; D008854:Microscopy, Electron; D009362:Neoplasm Metastasis / Q000473:pathology*; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure
D007633:Keratins; D010751:Phosphopyruvate Hydratase