Digoxin-specific Fab fragments impair renal function in the rabbit.
A 2 mg kg-1 intravenous bolus dose of digoxin-specific Fab fragments produced a 28% reduction in creatinine clearance in rabbits after 24 h. Urine output was reduced, while plasma and urinary creatinine concentrations were unaffected and increased, respectively. By 5 days the creatinine clearance had returned to normal. The fractional excretion of Na+ was nearly halved, indicating that the tubular reabsorption of Na+ increased to compensate for the reduced glomerular filtration rate, suggesting that tubular (as opposed to glomerular) function was not impaired.
Timsina
M P
MP
Department of Pharmacology and Clinical Pharmacology, University of Dundee, Ninewells Hospital and Medical School, UK.
Hewick
D S
DS
D000465:Algorithms; D000818:Animals; D003404:Creatinine / Q000097:blood / Q000652:urine; D004077:Digoxin / Q000276:immunology*; D005260:Female; D007140:Immunoglobulin Fab Fragments / Q000633:toxicity*; D007128:Immunoglobulin Fragments / Q000633:toxicity*; D007275:Injections, Intravenous; D011817:Rabbits; D012079:Renal Circulation / Q000187:drug effects*; D012964:Sodium / Q000097:blood / Q000652:urine
D007140:Immunoglobulin Fab Fragments; D007128:Immunoglobulin Fragments; D004077:Digoxin; D012964:Sodium; D003404:Creatinine