Differential effect of griseofulvin on interferon-gamma-induced HLA-DR and intercellular adhesion molecule-1 expression of human keratinocytes.
Interferon-gamma (IFN-gamma) induces major histocompatibility complex (MHC) class II antigen and intercellular adhesion molecule-1 (ICAM-1) expression on human epidermal keratinocytes. Griseofulvin, an extensively used antifungal agent, has been used effectively in the treatment of lichen planus, in which keratinocytes express both HLA-DR and ICAM-1 antigens. In this study, we investigated the effect of griseofulvin on IFN-gamma-induced MHC class II antigen and ICAM-1 expression of keratinocytes, and demonstrated that griseofulvin decreased IFN-gamma-induced HLA-DR but not ICAM-1 expression.
Department of Dermatology, Yamanashi Medical College, Japan.
K
K
Tamaki
A
A
Saitoh
N
N
Yasaka
D015703:Antigens, CD / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002478:Cells, Cultured; D005455:Fluorescent Antibody Technique; D006118:Griseofulvin / Q000494:pharmacology*; D006684:HLA-DR Antigens / Q000378:metabolism*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D007371:Interferon-gamma; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D011994:Recombinant Proteins
D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D006684:HLA-DR Antigens; D011994:Recombinant Proteins; D018799:Intercellular Adhesion Molecule-1; D006118:Griseofulvin; D007371:Interferon-gamma