Intrathecal synthesis of proteins: from immunoglobulins to prealbumin.
The assessment of proteins intrathecal synthesis (ITS) is an essential step in the CSF analysis. It can be established qualitatively by different ratios and quantitatively by empirical formulae. Schuller and Sagar's formula was proposed 10 years ago for the calculation of IgG ITS. From this calculation, the antibody specific activity of intrathecal immunoglobulins may be also evaluated. The same principle may be used for complement components and for different other CSF proteins. Two examples (concerning Fibronectin and prealbumin ITS) demonstrate the usefulness of this approach, which can be programmed by a computer.
Laboratoire de Neuroimmunologie, INSERM U. 134, Hôpital de la Salpêtrière.
E
E
Schuller
A
A
Gervais
J
J
Reboul
P
P
Lebon
A
A
Devillechabrolle
J M
JM
Huraux
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000378:metabolism; D000906:Antibodies / Q000134:cerebrospinal fluid; D000917:Antibody Formation; D002556:Cerebrospinal Fluid Proteins / Q000096:biosynthesis*; D005353:Fibronectins / Q000096:biosynthesis / Q000134:cerebrospinal fluid; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis* / Q000134:cerebrospinal fluid; D009103:Multiple Sclerosis / Q000276:immunology / Q000378:metabolism; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid / Q000276:immunology / Q000378:metabolism; D009494:Neurosyphilis / Q000276:immunology / Q000378:metabolism; D011228:Prealbumin / Q000096:biosynthesis / Q000134:cerebrospinal fluid
D000906:Antibodies; D002556:Cerebrospinal Fluid Proteins; D005353:Fibronectins; D007136:Immunoglobulins; D011228:Prealbumin