Microsomal formation of N-benzyl-4-hydroxymethylaniline from N-benzyl-4-methylaniline.
The in-vitro metabolism of N-benzyl-4-methylaniline was re-examined using male hamster and rabbit hepatic microsomes; both species generated N-benzyl-4-hydroxymethylaniline, confirmed by TLC and HPLC, comparison with authentic compound. Further confirmation of the formation of this metabolite was achieved by use of a rapid scan UV detector.
Chelsea Department of Pharmacy, King's College London, University of London, UK.
M
M
Ulgen
J W
JW
Gorrod
D000818:Animals; D001596:Benzylamines / Q000138:chemical synthesis* / Q000378:metabolism*; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006224:Cricetinae; D066298:In Vitro Techniques; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D011817:Rabbits; D014052:Toluidines / Q000737:chemistry*
D001596:Benzylamines; D014052:Toluidines; C078471:N-benzyl-4-hydroxymethylaniline; C047189:N-benzyl-4-toluidine