Clonal deletion of V beta 17 T cells in mice from natural populations.
In a panel of wild mice trapped in different geographical regions, the concomitant expression of V beta 17 T cell receptors and I-E histocompatibility molecules is frequent. By Southern blot analysis, eight forms of V beta 17 genes have been distinguished that encode five kinds of V beta 17 domains. Populations of Asia display the highest level of polymorphism and include all the V beta 17 forms and domains. The V beta 17 T cells of wild origin are deleted in mice expressing Mls-3 and related superantigens. Wild mice use V beta 17 domains different than the one of laboratory strains. Together with endogenous superantigens polymorphism, this accounts for the observed low frequency of clonal deletion cases in natural populations.
Jouvin-Marche
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Département d'Immunologie, Institut Pasteur (UA CNRS 359), Paris, France.
Marche
P N
PN
Cazenave
P A
PA
D000595:Amino Acid Sequence; D000818:Animals; D001208:Asia; D015139:Blotting, Southern; D005060:Europe; D015870:Gene Expression; D005828:Genetics, Population; D000949:Histocompatibility Antigens Class II / Q000096:biosynthesis; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics; D051379:Mice / Q000235:genetics* / Q000276:immunology; D008969:Molecular Sequence Data; D016366:Open Reading Frames / Q000235:genetics; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000096:biosynthesis / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D013601:T-Lymphocytes / Q000276:immunology*
D000949:Histocompatibility Antigens Class II; D016693:Receptors, Antigen, T-Cell, alpha-beta