[Betamethasone Sodium Phosphate Reference Standard (Control 881) of National Institute of Hygienic Sciences].
The raw material of betamethasone sodium phosphate was examined for preparation of the "Betamethasone Sodium Phosphate Reference Standard". Analytical results for the sample were as follows: pH 7.90; optical rotation + 100.5 degrees; IR spectrum the same as USP Reference Standard of Betamethasone Sodium Phosphate; TLC indicated no impurities, but 5 kinds of impurities were detected in small amounts by HPLC; water content 14.7%; assay 100.2% by HPLC. Based on the above results, this raw material was authorized to be the Reference Standard of the National Institute of Hygienic Sciences.
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Okada
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Hiroshige
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M
Tanaka
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M
Murai
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T
Kimura
D001623:Betamethasone / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000592:standards; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006077:Government Agencies; D006920:Hygiene; D007564:Japan; D010602:Pharmacopoeias as Topic
C028994:betamethasone sodium phosphate; D001623:Betamethasone