Stability of vitamin B1 in a commercial multivitamin syrup preparation.
Accelerated stability studies of a commercial vitamin B1 syrup preparation were carried out at 50, 60, 70 and 80 degrees C. The decomposition of vitamin B1 in the preparation followed pseudo-first order reaction kinetics. Apparent decomposition rate constants conformed to the Arrhenius equation. Apparent activation energy and shelf-life at 25 degrees C were estimated to be 24.2 kcal/mol and 3.3 years, respectively.
Bureau of Food & Drugs, Department of Health, Philippines.
E J
EJ
Villeza
Y
Y
Aso
S
S
Yoshioka
Y
Y
Takeda
D004304:Dosage Forms; D004355:Drug Stability; D013696:Temperature; D013831:Thiamine / Q000737:chemistry*; D013997:Time Factors
D004304:Dosage Forms; D013831:Thiamine