Induction of remission in a patient with Takayasu's arteritis by low dose pulses of methotrexate.
A 42 year old woman with Takayasu's arteritis responded to treatment with prednisone (60 mg daily) but developed severe side effects. Cyclophosphamide treatment did not produce a clinical improvement or steroid sparing effect. A treatment trial with a weekly pulse of low dose methotrexate improved her symptoms and the patency of her occluded left subclavian artery.
Mevorach
D
D
Department of Medicine, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel.
Leibowitz
G
G
Brezis
M
M
Raz
E
E
D000284:Administration, Oral; D000328:Adult; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage*; D011239:Prednisolone / Q000627:therapeutic use; D012074:Remission Induction / Q000379:methods; D013625:Takayasu Arteritis / Q000188:drug therapy*
D011239:Prednisolone; D008727:Methotrexate