Intermediate filament molecular biology.
Epidermal keratin intermediate filaments appear to have a structural function. The functions of other intermediate filaments are being elucidated using a combination of molecular genetic methods, including the expression of dominant negative mutant proteins and gene targeting. The differential expression of intermediate filament genes is regulated by both the accessibility of multiple regulatory elements and the activity or level of multiple positive and negative transcription factors.
Cancer Research Center, La Jolla Cancer Research Foundation, California 92037.
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Oshima
D000818:Animals; D005786:Gene Expression Regulation / Q000235:genetics; D007382:Intermediate Filaments / Q000502:physiology*; D007633:Keratins / Q000235:genetics* / Q000502:physiology; D051379:Mice; D008822:Mice, Transgenic; D014157:Transcription Factors / Q000235:genetics
D014157:Transcription Factors; D007633:Keratins