Integrin expression by human articular chondrocytes.
Expression of integrins, a family of cell adhesion proteins, by human articular cartilage chondrocytes in vivo has been studied by immunohistological techniques using cryostat sections and a panel of anti-integrin monoclonal antibodies. Chondrocytes strongly expressed beta 1 and alpha 5 integrin subunits, known to form the classical fibronectin receptor, VLA-5, strongly. alpha 1 was expressed more weakly and variably; alpha 3 was expressed by occasional cells only. Chondrocytes did not express beta 2, beta 3 or other integrin alpha subunits tested.
Department of Pathology, University of Edinburgh Medical School.
D M
DM
Salter
D E
DE
Hughes
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R
Simpson
D L
DL
Gardner
D015703:Antigens, CD / Q000032:analysis; D002358:Cartilage, Articular / Q000166:cytology* / Q000276:immunology / Q000648:ultrastructure*; D006801:Humans; D019012:Integrin beta1; D016023:Integrins / Q000502:physiology*
D015703:Antigens, CD; D019012:Integrin beta1; D016023:Integrins