[Studies on the excretion of urinary glycylprolyl dipeptidyl-aminopeptidase (GP-DAP) during normal pregnancy].
Several investigators reported that GP-DAP activity, one of dipeptidyl-aminopeptidases, increased in urine of patients with various renal diseases. In this study, we determined urinary GP-DAP and NAG activities of 165 subjects in normal pregnant women. It was clear that urinary GP-DAP was increased less than NAG with the progress of normal pregnancy. In conclusion, it is suggested that urinary GP-DAP may be a better marker than NAG for the discrimination of renal diseases from normal pregnancy.
Negishi
Y
Y
Department of Obstetrics and Gynecology, Tokyo Medical College.
Shibuya-Saruta
H
H
Sugiyama
M
M
D000118:Acetylglucosaminidase / Q000652:urine*; D015415:Biomarkers / Q000652:urine*; D018819:Dipeptidyl Peptidase 4; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000652:urine*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D011247:Pregnancy / Q000502:physiology / Q000652:urine*
D015415:Biomarkers; D000118:Acetylglucosaminidase; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D018819:Dipeptidyl Peptidase 4