Short echo time proton spectroscopy of human brain using a gradient head coil.
Short echo time, single voxel localized proton spectroscopy was accomplished using a stimulated echo (STEAM) sequence running on a Siemens 1.5-T system with a head coil incorporating the Z and Y gradients. Spectra from the temporal lobe, the cerebellum and mid brain were acquired from a group of normal volunteers using the following parameters: voxel size = 8 ml, TE = 22 msec, 512 signal averages and TR = 1.7 sec. STEAM spectra acquired with the small diameter gradients showed significantly fewer artifacts at short TE, allowing the observation of glutamate/glutamine, GABA, taurine, and inositol in addition to the prominent resonance of choline, creatine/phosphocreatine and N-acetylaspartate (NAA). The levels of chlorine, creatine and NAA were found to be significantly different in the three regions of the brain examined.
MR Research Center, Cleveland Clinic Foundation, OH 44195.
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D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D001923:Brain Chemistry; D002531:Cerebellum / Q000378:metabolism; D002794:Choline / Q000032:analysis; D003401:Creatine / Q000032:analysis; D005971:Glutamates / Q000032:analysis; D018698:Glutamic Acid; D005973:Glutamine / Q000032:analysis; D006801:Humans; D007294:Inositol / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D008636:Mesencephalon / Q000378:metabolism; D008875:Middle Aged; D010725:Phosphocreatine / Q000032:analysis; D013654:Taurine / Q000032:analysis; D013702:Temporal Lobe / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000032:analysis
D005971:Glutamates; D010725:Phosphocreatine; D005973:Glutamine; D013654:Taurine; D001224:Aspartic Acid; D018698:Glutamic Acid; D007294:Inositol; D005680:gamma-Aminobutyric Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline