The effect of third-trimester glycemic control on maternal and perinatal morbidities in pregestational diabetes mellitus.
From May 1974 to March 1989, 48 cases of pregestational diabetes mellitus treated during the third trimester of pregnancy at the Obstetric Clinic of the National Taiwan University Hospital had complete maternal-fetal chart, and were enrolled into this retrospective review. Of these cases, 28 were class B, 13 were class C and seven were class D-R. The maternal complications and perinatal morbidities of each class were reviewed. The mean fasting, postprandial plasma glucose concentrations and the mean excursion of plasma glucose levels were calculated for statistical analysis. Among the maternal complications, urinary tract infections and preterm labor were significantly associated with mean fasting plasma glucose concentrations. Among perinatal morbidities, neonatal respiratory distress and metabolic problems (including neonatal hyperbilirubinemia, symptomatic hypoglycemia, hypocalcemia and polycythemia) were significantly associated with mean plasma fasting glucose concentrations, and perinatal asphyxia was associated with a mean excursion of plasma glucose levels. In view of the paucity of knowledge about the etiology of complications in diabetic pregnancies, it is necessary to conduct a prospective multi-center study with well-characterized morbidities to search for the role of glycemic control in obstetric and perinatal complications.
Kuo
P L
PL
Department of Obstetrics & Gynecology, College of Medicine, National Cheng-Kung University, Tainan, Taiwan, R.O.C.
Lin
C K
CK
Lin
C R
CR
Chen
Y P
YP
Chen
H Y
HY
D001786:Blood Glucose / Q000032:analysis*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000517:prevention & control*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000517:prevention & control*; D011263:Pregnancy Trimester, Third; D011254:Pregnancy in Diabetics / Q000628:therapy*; D011295:Prenatal Care
D001786:Blood Glucose