Fertility after simulated Fowler-Stephens orchiopexy in rats.
In order to determine the effects of the Fowler-Stephens orchiopexy (FSO) on fertility, young rats underwent simulated FSO, FSO and concurrent contralateral orchiectomy (FSO/OR), unilateral orchiectomy (OR), or sham operation (controls). Twelve weeks after the operation, each male rat was mated to two proven-fertile female rats for 17 days (three ovulatory cycles). Two weeks later, both male and female rats were killed. No pregnancy resulted from the matings of the FSO/OR males. In contrast, pregnancy ensued in 13 of 16 (81%) females in the FSO group, 9 of 14 (64%) in the OR group, and 11 of 12 (92%) in the control group. There were no fertile males in the FSO/OR group. In the FSO group, eight of eight males induced pregnancy in at least one female; in the OR group, six of seven (86%) males were fertile as were all six males in the control group. No differences in litter size or fetal weight were observed between fertile females in various groups.
Kelly
R E
RE
Department of Surgery, UCLA School of Medicine.
Phillips
J D
JD
Fonkalsrud
E W
EW
Dindar
H
H
D000818:Animals; D001158:Arteries; D003456:Cryptorchidism / Q000601:surgery; D005260:Female; D005298:Fertility; D008026:Ligation; D008297:Male; D008722:Methods; D009919:Orchiectomy; D009929:Organ Size; D011183:Postoperative Complications; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000098:blood supply / Q000473:pathology / Q000601:surgery*; D014680:Veins