Strain-dependent effects of post-training dopamine receptor agonists and antagonists on memory storage in mice.
Post-training administration of the selective D1 or D2 agonists SKF 38393 and LY 171555 dose dependently impairs retention of an inhibitory avoidance response in DBA/2 mice. In agreement, the selective D1 or D2 antagonists SCH 23390 and (-)-sulpiride improve retention. These effects are opposite to those observed in the C57BL/6 strain, as previously reported. Moreover, B6D2F1 hybrids present a response to SKF 38393, LY 171555, SCH 23390, and (-)-sulpiride that parallels that of the C57BL/6 strain, thus suggesting that the neural mechanisms underlying the effects of DA agonists or antagonists on memory processes may be inherited through a dominant mode of inheritance.
Istituto di Psicobiologia e Psicofarmacologia, C.N.R., Roma, Italy.
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Cestari
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Castellano
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Cabib
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Puglisi-Allegra
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D015259:Dopamine Agents / Q000493:pharmacokinetics; D007858:Learning; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D009431:Neural Conduction / Q000187:drug effects; D012153:Retention, Psychology
D015259:Dopamine Agents