4-Methoxytranylcypromine, a monoamine oxidase inhibitor: effects on biogenic amines in rat brain following chronic administration.
4-Methoxytranylcypromine (MeOTCP), a ring-substituted analogue of the monoamine oxidase (MAO)-inhibiting antidepressant tranylcypromine (TCP), was investigated in the rat after chronic (28-day) administration and the results compared with those observed with TCP using equimolar doses of both drugs. At the dose tested, MeOTCP produced a greater inhibition of type A MAO in brain, liver, and heart than did TCP. Both drugs caused a reduction in the specific binding to beta-adrenergic and tryptamine receptors in cortex from brain. MeOTCP produced a marked increase in 5-hydroxytryptamine levels in pons-medulla, hypothalamus, and hippocampus relative to values in vehicle-treated rats and also produced a significant increase in these levels over those observed in the TCP-treated rats.
Sherry-McKenna
R L
RL
Department of Psychiatry, Mackenzie Centre, University of Alberta, Edmonton, Canada.
Baker
G B
GB
Mousseau
D D
DD
Coutts
R T
RT
Dewhurst
W G
WG
D000818:Animals; D001921:Brain / Q000187:drug effects*; D004298:Dopamine / Q000378:metabolism; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism; D013329:Structure-Activity Relationship; D014191:Tranylcypromine / Q000031:analogs & derivatives* / Q000494:pharmacology
D008996:Monoamine Oxidase Inhibitors; D018377:Neurotransmitter Agents; C068589:4-methoxytranylcypromine; D012701:Serotonin; D014191:Tranylcypromine; D008995:Monoamine Oxidase; D004298:Dopamine; D009638:Norepinephrine