Postprandial cholecystokinin secretion in elderly with protein-energy undernutrition.
OBJECTIVE
Malnutrition is currently observed in aged people, and cholecystokinin is an important peripheral satiety signal. The aim of this study was to examine the effect of aging and protein-energy malnutrition on postprandial cholecystokinin (CCK) release.


METHODS
Non-randomized, cross-sectional comparison by age group.


METHODS
Gastroenterology section of a teaching hospital.


METHODS
Twenty-one human volunteers divided into three groups: young healthy subjects (Group 1: mean 29 years, n = 7), aged healthy subjects (Group 2, mean 80 years, n = 7), and aged subjects with an important degree of malnutrition (Group 3, mean 84.6 years, n = 7).


METHODS
Each subject ingested a standardized liquid meal after an overnight fast.


METHODS
Plasma cholecystokinin was measured using a sensitive bioassay before and after the ingestion of the liquid meal.


RESULTS
Basal cholecystokinin levels were similar (0.9 to 1 pM equivalent CCK-8) in the three groups. Postprandial levels were significantly increased over basal (P less than 0.05). The maximal cholecystokinin value was lower in Group 1 (3.5 +/- 0.8 pM equivalent CCK-8) and Group 2 (3.3 +/- 0.77 pM equivalent CCK-8) than in Group 3 (8.3 +/- 2 pM equivalent CCK-8) (P less than 0.05). Integrated plasma cholecystokinin was also similar in Group 1 (171 +/- 38 pM.60 min), (P less than 0.05).


CONCLUSIONS
The increase of postprandial maximal levels of cholecystokinin is more related to malnutrition than to aging.
Berthélemy
P
P
Service des Maladies d l'Appareil Digestif, CHU Rangueil, Toulouse, France.
Bouisson
M
M
Vellas
B
B
Moreau
J
J
Nicole-Vaysse
Albarede
J L
JL
Ribet
A
A
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D000681:Amylases / Q000378:metabolism; D001681:Biological Assay / Q000592:standards; D015992:Body Mass Index; D002766:Cholecystokinin / Q000097:blood* / Q000378:metabolism / Q000502:physiology; D003430:Cross-Sectional Studies; D004435:Eating / Q000502:physiology*; D002149:Energy Intake; D006801:Humans; D009752:Nutritional Status; D011228:Prealbumin / Q000032:analysis; D011502:Protein-Energy Malnutrition / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D012177:Retinol-Binding Proteins / Q000032:analysis; D054839:Retinol-Binding Proteins, Plasma; D012528:Satiety Response / Q000187:drug effects; D012709:Serum Albumin / Q000032:analysis
D011228:Prealbumin; D012177:Retinol-Binding Proteins; D054839:Retinol-Binding Proteins, Plasma; D012709:Serum Albumin; D002766:Cholecystokinin; D000681:Amylases