Is yohimbine-induced increase in salivary secretion a kinin-dependent mechanism?
We have previously reported that the alpha 2-adrenoceptor antagonist yohimbine induced a significant increase in both salivary flow rate and kallikrein output. In order to assess the possible role of the kinin-kallikrein system in the increase in salivary secretion elicited by yohimbine, the effects of aprotinin, an inhibitor of kallikrein activity, were investigated in yohimbine-treated conscious dogs. Aprotinin (at a dose, 5000 IU/kg iv, which reduced both resting and yohimbine-induced increase in kininogenase and amidolytic activities of saliva) which remained inactive alone, failed to modify the increase in salivary volume elicited by yohimbine (0.5 mg/kg iv). These results show that the rise in salivary flow rate observed under alpha 2-adrenoceptor antagonist is not induced by the kinin-kallikrein system. The release of kallikrein into saliva observed after yohimbine is rather the consequence than the cause of the increase in salivary secretion.
Bagheri
H
H
Laboratoire de Pharmacologie Médicale et clinique, INSERM U317, Faculté de Médecine, Toulouse, France.
Bompart
G
G
Girolami
J P
JP
Montastruc
J L
JL
Montastruc
P
P
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology; D004285:Dogs; D005260:Female; D007610:Kallikreins / Q000032:analysis; D007705:Kinins / Q000502:physiology*; D008297:Male; D012463:Saliva / Q000737:chemistry; D012472:Salivation / Q000187:drug effects*; D015016:Yohimbine / Q000494:pharmacology*
D007705:Kinins; D015016:Yohimbine; D007611:Aprotinin; D007610:Kallikreins