Differential effects of 3,4,5,3',4',5'-hexachlorobiphenyl (HCB) on interrenal steroidogenesis in male and female rainbow trout Oncorhynchus mykiss.
1. The conversion of progesterone to 17 alpha-hydroxyprogesterone (17 alpha-OHP), 11-deoxycortisol (11-DOCR) and deoxycorticosterone (DOC) was significantly higher in female rainbow trout than in male trout; in contrast, the interrenal production of cortisol (CR) plus cortisone (CN) was higher in males than in females. 2. Following treatment with 1 mg/kg of HCB, the interrenal conversion of progesterone to 17 alpha-OHP and 11-DOCR was significantly increased in male and female trout but at 20 mg/kg of HCB, the production of these metabolites was increased in males and decreased in females; CR+CN production was unchanged after HCB treatment in both sexes.
Miranda
C L
CL
Department of Agricultural Chemistry, Oregon State University, Corvallis 97331.
Henderson
M C
MC
Wang
J L
JL
Chang
H S
HS
Hendricks
J D
JD
Buhler
D R
DR
D019326:17-alpha-Hydroxyprogesterone; D000818:Animals; D001345:Autoradiography; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D003348:Cortisone / Q000096:biosynthesis; D003350:Cortodoxone / Q000378:metabolism; D003900:Desoxycorticosterone / Q000096:biosynthesis; D005260:Female; D006854:Hydrocortisone / Q000096:biosynthesis; D006908:Hydroxyprogesterones / Q000378:metabolism; D007401:Interrenal Gland / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D011374:Progesterone / Q000378:metabolism; D012727:Sex Characteristics; D013256:Steroids / Q000096:biosynthesis*; D014337:Trout / Q000378:metabolism
D006908:Hydroxyprogesterones; D013256:Steroids; D003900:Desoxycorticosterone; D011374:Progesterone; D019326:17-alpha-Hydroxyprogesterone; D011078:Polychlorinated Biphenyls; C027309:3,4,5,3',4',5'-hexachlorobiphenyl; D003348:Cortisone; D003350:Cortodoxone; D006854:Hydrocortisone