Effect of proximal gastric vagotomy on the activity of hydrogen, potassium-stimulated ATPase in the gastric mucosa of patients with duodenal ulcer.
OBJECTIVE
To find out if there was a correlation between hydrogen, potassium stimulated ATPase (H,K-ATPase) activity and gastric acid secretion in patients with duodenal ulcers after proximal gastric vagotomy.


METHODS
Retrospective study.


METHODS
Regional referral center.


METHODS
61 patients with chronic duodenal ulcers divided into three groups: patients who had not been operated on but had exacerbations of their symptoms (n = 39): those who had been treated successfully by proximal gastric vagotomy either less than 1 year ago (n = 7) or greater than or equal to 1 year ago (n = 9): and those patients who presented with recurrent ulceration after proximal gastric vagotomy (n = 6).


METHODS
Measurement of H,K-ATPase activity and gastric acid secretion.


RESULTS
There was a decrease in H,K-ATPase activity after effective vagotomy, and enzyme activity was the lowest in patients who had been operated on 1 year ago. Both H,K-ATPase and gastric acid secretion were decreased by proximal gastric vagotomy.


CONCLUSIONS
There may be a gradual recovery of gastric H,K-ATPase activity with time after proximal gastric vagotomy.
Department of Surgery, Pelgulinna Hospital, Tallinn, Estonia.
M
M
Leibur
A T
AT
Kengsepp
U
U
Sibul
R
R
Truve
D000251:Adenosine Triphosphatases / Q000032:analysis / Q000378:metabolism*; D000328:Adult; D002908:Chronic Disease; D004381:Duodenal Ulcer / Q000201:enzymology* / Q000601:surgery; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000737:chemistry / Q000201:enzymology* / Q000378:metabolism; D005755:Gastrins / Q000097:blood; D017506:H(+)-K(+)-Exchanging ATPase; D006801:Humans; D008297:Male; D008875:Middle Aged; D014629:Vagotomy, Proximal Gastric
D005755:Gastrins; D000251:Adenosine Triphosphatases; D017506:H(+)-K(+)-Exchanging ATPase