[Syndrome of macrophagic activation with hemophagocytosis in human immunodeficiency virus infection].
The authors report two cases of hematophagic histiocytosis in HIV positive patients. In the first case, a patient with Kaposi sarcoma and Mycobacterium avium infection had a rapidly deteriorating course with progressive pancytopenia and death, as generally described in the literature. In the second case, hematophagic histiocytosis appeared during HIV primo infection and reversed spontaneously. Although few cases of hemophagocytic syndrome have been reported in HIV positive patient, it could represent an underestimated cause of pancytopenia. Both opportunistic microorganisms and HIV are able to cause hematophagic histiocytosis.
Pellegrin
J L
JL
Clinique de Médecine Interne et Maladies Infectieuses, Hôpital Saint-André, Bordeaux.
Merlio
J P
JP
Lacoste
D
D
Barbeau
P
P
Brossard
G
G
Beylot
J
J
Leng
B
B
D000328:Adult; D017809:Fatal Outcome; D015658:HIV Infections / Q000145:classification / Q000150:complications*; D015497:HIV-1; D015616:Histiocytosis, Non-Langerhans-Cell / Q000097:blood / Q000382:microbiology*; D006801:Humans; D008262:Macrophage Activation; D008297:Male; D010198:Pancytopenia / Q000097:blood / Q000209:etiology; D012075:Remission, Spontaneous
Syndrome d'activation macrophagique avec hémophagocytose au cours de l'infection par le virus de l'immunodéficience humaine.