New approaches to the synthesis of antiviral nucleosides.
There is a pressing, worldwide need for new antiviral agents. The chemical synthesis of novel nucleosides for chemotherapeutic screening usually involves multistage processes which can be time consuming. The application of enzymatic methods for the synthesis and modification of antiviral nucleosides shows great promise because of the simplicity and high specificity of enzymatic reactions.
Hutchinson
D W
DW
Department of Chemistry, University of Warwick, Coventry, UK.
D015720:5'-Nucleotidase / Q000378:metabolism; D000243:Adenosine Deaminase / Q000378:metabolism; D000998:Antiviral Agents; D055598:Chemical Phenomena; D002621:Chemistry; D004950:Esterases / Q000378:metabolism; D006031:Glycosylation; D009705:Nucleosides / Q000096:biosynthesis*
D000998:Antiviral Agents; D009705:Nucleosides; D004950:Esterases; D015720:5'-Nucleotidase; D000243:Adenosine Deaminase