Virostatic in vivo effect of elliptinium on Friend's retrovirus (a model for HIV infection).
As we had discovered the virostatic effects of some analogues of acriflavine, a non-oncostatic intercalating agent, on HIV1 and on its best murine model, Friend's virus [7], we then studied other non- or poorly oncostatic intercalating agents, in particular ellipticins (whose negligible cytostatic effect with methoxy-9-ellipticin we first published. We report in this paper the in vivo virostatic effect of 2-methyl-9-hydroxy-ellipticinium (elliptinium) on Friend's virus.
Institut du Cancer et d'Immunogénétique, Hôpital Paul-Brousse, Villejuif, France.
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D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004611:Ellipticines / Q000737:chemistry / Q000494:pharmacology*; D005622:Friend murine leukemia virus / Q000187:drug effects*; D007364:Intercalating Agents / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008811:Mice, Inbred DBA; D015215:Zidovudine / Q000494:pharmacology
D000970:Antineoplastic Agents; D004611:Ellipticines; D007364:Intercalating Agents; C027767:elliptinium; D015215:Zidovudine