The influence of chronic nicotine treatment on stress-induced gastric ulceration and emptying rate in rats.
Ten-day treatment with nicotine (5, 25 or 50 micrograms/ml drinking water) dose-dependently intensified gastric ulceration induced by cold-restraint, and emptying rate. Stomach contractions produced by graded doses of bethanechol i.v. were elevated further by nicotine treatment. It is suggested that chronic nicotine administration produces hypersensitivity of the gastric muscarinic receptors; stomach hypermotility contributes to the ulcer-worsening action of the alkaloid.
Qiu
B S
BS
Department of Pharmacology, Faculty of Medicine, University of Hong Kong.
Cho
C H
CH
Ogle
C W
CW
D000818:Animals; D018723:Bethanechol; D001626:Bethanechol Compounds / Q000494:pharmacology; D003080:Cold Temperature; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D009538:Nicotine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000473:pathology / Q000503:physiopathology*; D013315:Stress, Psychological / Q000503:physiopathology*
D001626:Bethanechol Compounds; D018723:Bethanechol; D009538:Nicotine