Elevated CSF glutamate in Rett syndrome.
The concentration of free amino acids was measured in the cerebrospinal fluid of four patients with Rett syndrome. The reference material were patients with autistic disorder who had CSF aminoacid levels similar to those reported for healthy children. The concentration of glutamate-but of no other amino acid-was markedly elevated in the CSF of the RS patients. The results are discussed in the context of excitotoxicity in neurodegenerative disease.
Hamberger
A
A
Institute of Neurobiology, University of Göteborg, Sweden.
Gillberg
C
C
Palm
A
A
Hagberg
B
B
D000328:Adult; D000596:Amino Acids / Q000134:cerebrospinal fluid; D001321:Autistic Disorder / Q000134:cerebrospinal fluid / Q000175:diagnosis; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000134:cerebrospinal fluid; D005971:Glutamates / Q000134:cerebrospinal fluid*; D018698:Glutamic Acid; D006801:Humans; D015518:Rett Syndrome / Q000134:cerebrospinal fluid* / Q000175:diagnosis
D000596:Amino Acids; D005904:Glial Fibrillary Acidic Protein; D005971:Glutamates; D018698:Glutamic Acid