A role for IGF-1 in the rescue of CNS neurons following hypoxic-ischemic injury.
Three days after unilateral hypoxic-ischemic injury in infant rats insulin-like growth factor 1 (IGF-1) production by astrocytes was enhanced in the injured region. This was associated with increased expression of mRNA for IGF binding protein-3 but not for binding protein-1. In adult rats a single lateral cerebroventricular injection of IGF-1 two hours following a similar injury markedly reduced neuronal loss. It is suggested that endogenous IGF-1 is neurotrophic and that centrally administered IGF-1 may have therapeutic potential for brain injury.
Department of Paediatrics, University of Auckland, New Zealand.
P
P
Gluckman
N
N
Klempt
J
J
Guan
C
C
Mallard
E
E
Sirimanne
M
M
Dragunow
M
M
Klempt
K
K
Singh
C
C
Williams
K
K
Nikolics
D000818:Animals; D001253:Astrocytes / Q000502:physiology*; D001921:Brain / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D002545:Brain Ischemia / Q000473:pathology / Q000503:physiopathology* / Q000517:prevention & control; D002352:Carrier Proteins / Q000235:genetics; D002552:Cerebral Ventricles / Q000187:drug effects; D000860:Hypoxia / Q000503:physiopathology*; D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis / Q000502:physiology* / Q000627:therapeutic use; D009474:Neurons / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats
D002352:Carrier Proteins; D018969:Insulin-Like Growth Factor Binding Proteins; D012333:RNA, Messenger; D007334:Insulin-Like Growth Factor I