Insulin signal transduction: the role of protein phosphorylation.
Recent evidence suggests that the mechanism of insulin action depends in part on protein phosphorylation on tyrosine residues. A cascade of phosphorylation/dephosphorylation reactions is proposed to modulate multiple enzymes involved in metabolism, protein synthesis, and cell growth. Direct evidence is presented for the phosphorylation of myelin basic protein and microtubule-associated protein 2 on tyrosine residues by the insulin receptor.
Pillion
D J
DJ
Department of Pharmacology, University of Alabama, Birmingham.
Kim
S J
SJ
Kim
H
H
Meezan
E
E
D000818:Animals; D006801:Humans; D007328:Insulin / Q000502:physiology*; D008954:Models, Biological; D004676:Myelin Basic Protein / Q000378:metabolism; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D011972:Receptor, Insulin / Q000502:physiology*; D015398:Signal Transduction; D013379:Substrate Specificity
D007328:Insulin; D004676:Myelin Basic Protein; D011505:Protein-Tyrosine Kinases; D011972:Receptor, Insulin