Antagonism of medetomidine sedation by atipamezole in pigs.
The efficacy of atipamezole as a medetomidine antagonist was evaluated in pigs. The atipamezole doses (intramuscularly) were 80, 160, 320 and 480 micrograms/kg of body weight, which were one, two, four and six times higher than the preceding medetomidine dose (80 micrograms/kg, intramuscularly). Atipamezole effectively reversed medetomidine-induced sedation, and the optimal action was seen at doses of 160 and 320 micrograms/kg. Recovery from sedation was quick and smooth, and adverse effects such as hyperactivity or tachycardia were minimal with either dose.
Nishimura
R
R
Department of Veterinary Surgery, Faculty of Agriculture, University of Tokyo, Japan.
Kim
H
H
Matsunaga
S
S
Sakaguchi
M
M
Sasaki
N
N
Tamura
H
H
Takeuchi
A
A
D000316:Adrenergic alpha-Agonists / Q000037:antagonists & inhibitors*; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006993:Hypnotics and Sedatives / Q000037:antagonists & inhibitors*; D007093:Imidazoles / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D008297:Male; D020926:Medetomidine; D013552:Swine / Q000502:physiology
D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D006993:Hypnotics and Sedatives; D007093:Imidazoles; C050701:atipamezole; D020926:Medetomidine