Tactile interference differentiates sub-components of N20, P20 and P29 in the human cortical surface somatosensory evoked potential.
Somatosensory evoked potentials (SEPs) to median nerve stimulation were recorded from up to 64 locations on the exposed cortical surface in 19 patients undergoing intracranial surgery for epilepsy and/or tumour removal. In view of previously described 'interference' effects on scalp SEPs, a continuous light tactile stimulus was applied to the palm and the first 3 digits of the stimulated hand in order to try to differentiate components due to input from cutaneous and other sensory receptors. The first cortically generated potentials, N20 at postcentral locations and P20 precentrally, could each be resolved into 2 subcomponents separated by about 2.5 msec. The later subcomponent was consistently the more attenuated by the interfering stimulus and is postulated to be due to input from rapidly adapting cutaneous mechanoreceptors. The earlier subcomponent could be due to input from muscle afferents or from slowly adapting cutaneous receptors which the interfering stimulus would have activated to a lesser degree. In 2 cases the P29 potentials recorded from regions of the postcentral gyrus were dissociated. In one case the potentials recorded at adjacent electrodes were attenuated to differing degrees, and in the other the effect was maximal at different locations when the thumb, index and middle fingers were stimulated separately. The method therefore appears capable of distinguishing regions of the postcentral gyrus concerned with cutaneous input from different parts of the hand.
Neuropsychology Laboratory, V.A. Medical Center, West Haven, CT 06516.
S J
SJ
Jones
T
T
Allison
G
G
McCarthy
C C
CC
Wood
D000293:Adolescent; D000328:Adult; D000368:Aged; D001931:Brain Mapping; D005073:Evoked Potentials, Somatosensory; D005260:Female; D006225:Hand / Q000294:innervation; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000502:physiology; D008875:Middle Aged; D011930:Reaction Time / Q000502:physiology; D013003:Somatosensory Cortex / Q000502:physiology*; D014110:Touch / Q000502:physiology*