Neuroleptic-induced movement disorders and body iron status.
1. The distribution of iron in the human brain, what is known about its biological functions, and the interaction of neuroleptics with iron suggest that this trace metal may play an important role in the pathogenesis of neuroleptic-induced movement disorders (NIMD). 2. The availability of magnetic resonance imaging has made some of the hypotheses testable in human subjects. 3. This article is a brief overview of the current literature on the association between NIMD and brain iron.
Sachdev
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Neuropsychiatric Institute, Prince Henry Hospital, University of New South Wales, Sydney, Australia.
D014150:Antipsychotic Agents / Q000009:adverse effects*; D001923:Brain Chemistry; D004409:Dyskinesia, Drug-Induced / Q000378:metabolism*; D006801:Humans; D007501:Iron / Q000032:analysis* / Q000502:physiology
D014150:Antipsychotic Agents; D007501:Iron