[Preliminary study of cartilage repair with autologous periosteum and fibrin adhesive system].
The potential surgical transplantation with autogenous periosteal grafts and Fibrin Adhesive System (FAS) was attempted in a rabbit model. The grafts were taken from the tibia, transplanted and fixed with FAS to artificial full-thickness (0.4 x 0.3 cm) defect on the femoral condyle. Histologic and ultrastructural findings revealed chondrocyte regeneration in the control, grafted, and graft/FAS treated group at week 6; however, chondrogenesis of the reparative tissue was best demonstrated in the graft/FAS group. At week 12, the interface between the reparative tissue and the surrounding tissue was invisible in the FAS/graft group, as compared with the well-defined interface in the grafted group and the control. The results strongly suggest that FAS-treated periosteal transplant is a potential model for the repair of articular cartilage defects. Although the results are preliminary, all seem promising in the clinical aspects.
Department of Orthopaedic Surgery, School of Medicine, National Taiwan University, Taipei, Republic of China.
C L
CL
Tsai
T K
TK
Liu
S L
SL
Fu
J H
JH
Perng
A C
AC
Lin
D000818:Animals; D002356:Cartilage / Q000601:surgery* / Q000648:ultrastructure; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D008297:Male; D010521:Periosteum / Q000637:transplantation*; D011817:Rabbits; D014182:Transplantation, Autologous
D015718:Fibrin Tissue Adhesive