Visualization of dopamine D3-like receptors in human brain with [125I]epidepride.
In sections of human brain containing the striatum (caudate, nucleus, putamen, nucleus accumbens) the competition for binding of [125I]epidepride by compounds with differing selectivity for dopamine D2 and D3 receptors was examined. Domperidone showed higher affinity for D2-like than D3-like sites whereas 7-OH-DPAT (7-hydroxy-2-(N,N-di-n-propylamino)tetralin) and quinpirole demonstrated the reverse selectivity. The pattern of [125I]epidepride binding in the presence of a high concentration of domperidone was negligible in the dorsal striatum but indicated islands of dense binding to D3-like receptors in the nucleus accumbens and ventral putamen.
Department of Clinical Pharmacology, Royal College of Surgeons, Dublin, Ireland.
A M
AM
Murray
H
H
Ryoo
J N
JN
Joyce
D001345:Autoradiography; D001549:Benzamides / Q000378:metabolism*; D001665:Binding Sites; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism*; D004294:Domperidone / Q000378:metabolism; D015259:Dopamine Agents / Q000378:metabolism; D004873:Ergolines / Q000378:metabolism; D006801:Humans; D011759:Pyrrolidines / Q000378:metabolism*; D019257:Quinpirole; D011954:Receptors, Dopamine / Q000378:metabolism*
D001549:Benzamides; D015259:Dopamine Agents; D004873:Ergolines; D011759:Pyrrolidines; D011954:Receptors, Dopamine; C063525:epidepride; D019257:Quinpirole; D004294:Domperidone