Effect of lithocholic acid feeding on plasma lipoproteins and binding of radioiodinated human lipoproteins to hepatic membranes in rats.
1. Male Sprague-Dawley rats fed diets containing 0.25% lithocholic acid for 6 weeks exhibited elevated serum cholesterol. 2. The rats were fed diets containing 5 or 20% fat with and without the lithocholate and/or oxytetracycline-HCl. 3. The cholesterol elevation was associated with high density lipoprotein (HDL) and not very low density lipoprotein (VLDL) or low density lipoprotein (LDL). 4. Specific binding of human [125I]HDL to hepatic membranes was lowered in lithocholate-fed rats, but binding of human [125I]LDL to these membranes was not affected.
Lipid Nutrition Laboratory, Beltsville Human Nutrition Research Center, U.S. Department of Agriculture, MD 20705.
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G
Loo
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Kessie
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Berlin
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Nair
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D006801:Humans; D007457:Iodine Radioisotopes; D008074:Lipoproteins / Q000097:blood*; D008095:Lithocholic Acid / Q000008:administration & dosage*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D007457:Iodine Radioisotopes; D008074:Lipoproteins; D008095:Lithocholic Acid; D002784:Cholesterol