The actions of phorbol esters upon isolated calcium currents of Helix aspersa neurones.
1. Voltage-clamp recordings have been made from identified neurones in the suboesophageal ganglia of Helix aspersa. 2. Calcium currents were isolated pharmacologically and studied under two-electrode voltage-clamp. 3. PdBu but not PMA caused a transient enhancement followed by an irreversible inhibition of the calcium current. 4. It is concluded that activation of protein kinase C within these neurones may show selectivity with respect to the exogenous activator used.
Department of Physiology, Medical School, Edgbaston, Birmingham, U.K.
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Gibson
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Logan
D000818:Animals; D002118:Calcium / Q000502:physiology; D015220:Calcium Channels / Q000187:drug effects*; D006372:Helix, Snails; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D015240:Phorbol 12,13-Dibutyrate / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*
D015220:Calcium Channels; D015240:Phorbol 12,13-Dibutyrate; D013755:Tetradecanoylphorbol Acetate; D002118:Calcium