Thirty-one new RFLP systems detected by twenty-four DNA markers on human chromosome 10.
Thirty-one new RFLP systems corresponding to 24 loci have been identified from a chromosome 10-specific cosmid library. Twelve of the markers on the proximal long arm (cen-q11.2) of this chromosome, including four RFLP systems for the RET locus, will be especially useful in efforts to identify the gene responsible for multiple endocrine neoplasia type 2A (MEN2A). The new panel of markers also may contribute to fine-scale mapping of tumor suppressor genes associated with glioblastoma multiforme or renal cell carcinoma, because allelic deletions in these tumors have implied the presence of a tumor suppressor gene(s) on chromosome 10.
Division of Biochemistry, Cancer Institute, Tokyo, Japan.
T
T
Tokino
S
S
Takiguchi
A
A
Tanigami
T
T
Bragg
C
C
Jones
Y
Y
Nakamura
D002879:Chromosomes, Human, Pair 10; D003360:Cosmids; D004247:DNA / Q000235:genetics; D005819:Genetic Markers; D006801:Humans; D009377:Multiple Endocrine Neoplasia / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length
D005819:Genetic Markers; D004247:DNA