Somatosensory stimulation causes autonomic vasodilatation in cat lip.
1. Electrical stimulation of the infra-orbital nerve and the maxillary buccal gingiva caused an increase in ipsilateral lip blood flow in a stimulus intensity-dependent manner in anaesthetized cats. 2. The reflex vasodilator response was resistant to blockade by antimuscarinic (atropine), antiadrenergic (phentolamine and propranolol) and antihistaminergic (tripelennamine) but sensitive to ganglionic blocking agent (hexamethonium). 3. The reflex vasodilator response was unaffected by section of the ipsilateral cervical sympathetic trunk and facial nerve root, but was completely abolished by ipsilateral section of the glossopharyngeal nerve root. 4. The vasodilator response elicited by stimulation of the facial and glosso-pharyngeal nerves was never affected by lesion of the ipsilateral pterygopalatine ganglion. 5. Local anaesthesia or section of the inferior alveolar nerve abolished the vasodilator effects of stimulation of the facial and the glossopharyngeal nerves. 6. These results suggest that there is a somato-autonomic reflex vasodilator system mediated via final neurons that are not cholinergic, and that the parasympathetic vasodilator fibres emerge from the brain stem with the glossopharyngeal nerve and reach the blood vessels via the otic ganglion and the inferior alveolar nerve in the cat mandibular lip.
Department of Physiology, Tohoku University School of Dentistry, Sendai, Japan.
H
H
Izumi
K
K
Karita
D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002415:Cats; D004558:Electric Stimulation; D005730:Ganglionic Blockers / Q000494:pharmacology; D018738:Hexamethonium; D006584:Hexamethonium Compounds / Q000494:pharmacology; D008046:Lip / Q000098:blood supply* / Q000294:innervation; D010275:Parasympathetic Nervous System / Q000502:physiology*; D012018:Reflex / Q000502:physiology; D012039:Regional Blood Flow; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*
D005730:Ganglionic Blockers; D006584:Hexamethonium Compounds; D018738:Hexamethonium