Antioxidant effect on renal scarring following infection of mannose-sensitive-piliated bacteria.
Renal scars have been considered to occur in later stages of chronic pyelonephritis. In our experimental pyelonephritis model, bacteria which possessed mannose-sensitive (MS) pili on the surface promoted renal scarring following inoculation to the renal parenchyma. Polyethylene glycol-modified superoxide dismutase (PEG-SOD) and 2-O-octadecylascorbic acid (CV3611) significantly suppressed scarring when administered orally or parenterally during the early stage of kidney infection with MS-piliated bacteria. These findings suggest that the superoxide and other active oxygens play an important role in renal scarring following infection and that PEG-SOD and CV3611 may be agents capable of preventing renal scarring following bacterial pyelonephritis.
Department of Urology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
T
T
Matsumoto
Y
Y
Mitzunoe
N
N
Ogata
M
M
Tanaka
K
K
Takahashi
J
J
Kumazawa
D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D002921:Cicatrix / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D004351:Drug Resistance; D004926:Escherichia coli / Q000166:cytology / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000150:complications* / Q000473:pathology; D005260:Female; D010861:Fimbriae, Bacterial / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects / Q000382:microbiology* / Q000473:pathology; D008358:Mannose / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000494:pharmacology; D011704:Pyelonephritis / Q000382:microbiology* / Q000473:pathology; D051381:Rats; D016868:Serratia Infections / Q000150:complications* / Q000473:pathology; D012706:Serratia marcescens / Q000166:cytology / Q000302:isolation & purification; D013482:Superoxide Dismutase / Q000008:administration & dosage / Q000494:pharmacology
D000975:Antioxidants; D011092:Polyethylene Glycols; C061185:2-O-octadecylascorbic acid; D013482:Superoxide Dismutase; C063471:polyethylene glycol-superoxide dismutase; D008358:Mannose; D001205:Ascorbic Acid