Effects of lithium and haloperidol on human sperm motility in-vitro.
Two psychotropic drugs, lithium and haloperidol, were evaluated for their in-vitro effects on sperm motility using a transmembrane migration method. Sperm motility was measured either immediately after semen had been mixed with the drug or after a 2 h incubation period at 37 degrees C. Lithium inhibited human sperm motility in a dose-dependent manner with an EC50 of 10 mM when the semen-lithium mixture had been incubated. Sperm motility was increased to 127% of control when semen had been incubated with 0.027 microM haloperidol; this concentration was within the therapeutic range.
Shen
M R
MR
Department of Neurology, Kaohsiung Medical College, Taiwan, Republic of China.
Yang
R C
RC
Chen
S S
SS
D004305:Dose-Response Relationship, Drug; D006220:Haloperidol / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D013081:Sperm Motility / Q000187:drug effects*
D008094:Lithium; D006220:Haloperidol