Simulated assembly line performance following ingestion of cetirizine or hydroxyzine.
Twelve healthy subjects participated in three daytime work periods, in a double-blind repeated measures Latin square design. Subjects received cetirizine (10 mg), hydroxyzine (25 mg), or placebo at 0800. Performance was measured each day during eight 50-minute test periods on a simulated assembly line task between 0830 and 1700. Before entry into the study, subjects were trained to a minimum 80% correction rate on the performance task. Performance decrements were consistently associated with hydroxyzine but not with cetirizine. Subjects made fewer correct responses with hydroxyzine compared with both cetirizine and placebo. Subjectively, participants reported feeling sleepier and performing worse during the hydroxyzine condition than following placebo. Cetirizine, however, did not differ from the other two conditions on self-assessments of alertness or performance. These findings support the hypothesis that objective measures of human functioning are more specific than are subjective measures.
Sleep Disorders and Research Center, Deaconess Hospital, St. Louis, Missouri.
J K
JK
Walsh
M J
MJ
Muehlbach
P K
PK
Schweitzer
D000328:Adult; D017332:Cetirizine; D003198:Computer Simulation; D005260:Female; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006801:Humans; D006919:Hydroxyzine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008297:Male; D016272:Occupational Health; D011597:Psychomotor Performance / Q000187:drug effects*
D006634:Histamine H1 Antagonists; D006919:Hydroxyzine; D017332:Cetirizine