[Changes in somatosensory evoked potentials in pharmacogenic myoclonia].
Transient increases of the early cortical somatosensory evoked potentials (SSEP) were observed in 9 patients who received antidepressant and/or neuroleptic treatment. All patients developed myoclonus, and 2 had grand mal seizures. Three cases--one 20-, one 17- and one 15-year-old patient--are presented in detail. Similar observations have been reported in elderly patients. Possible underlying mechanisms and the potential value of the SSEP in identifying and monitoring patients at risk of developing psychotropic drug-induced side-effects are briefly discussed.
Zentralinstitut für Seelische Gesundheit, Mannheim.
H
H
Förstl
B
B
Pohlmann-Eden
A
A
Rothenberger
D000293:Adolescent; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002997:Clomipramine / Q000008:administration & dosage / Q000009:adverse effects; D003866:Depressive Disorder / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects*; D004831:Epilepsies, Myoclonic / Q000139:chemically induced*; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy*; D011930:Reaction Time / Q000187:drug effects; D012559:Schizophrenia / Q000188:drug therapy*
D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D002997:Clomipramine
Veränderungen somatosensibel evozierter Potentiale bei pharmakogener Myoklonie.