Stimulation of rat pituitary tumoral cell proliferation in vitro by tetra- and pentagastrin.
The effects of the active gastrin fragments, penta- and tetragastrin on the incorporation of tritiated thymidine into the rat pituitary tumoral cells were investigated in vitro. The significant stimulation of 3H-thymidine incorporation was observed as an effect of the investigated substances. The putative role of gastrin as an autocrine growth factor active in pituitary tumorigenesis was discussed.
Pawlikowski
M
M
Institute of Endocrinology, Medical University of Lódź, Poland.
Kunert-Radek
J
J
Döhler
K D
KD
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D005260:Female; D010418:Pentagastrin / Q000494:pharmacology*; D010911:Pituitary Neoplasms / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013758:Tetragastrin / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D013758:Tetragastrin; D010418:Pentagastrin