[Cyanocobalamin Reference Standard (Control 891) of National Institute of Hygienic Sciences].
Cyanocobalamin was tested for preparation on the "Cyanocobalamin Reference Standard (Control 891)". Analytical data obtained were as follows: loss on drying, 9.77%; infrared spectrum, same as that of the Cyanocobalamin Reference Standard (Control 871); thin-layer chromatography, five contaminants were detected; high-performance liquid chromatography, nine contaminants were detected; assay, 100.00% by JP XI method and 99.79% by HPLC method in terms of the JP Reference Standard (Control 871), respectively. On the basis of the above results, this material was authorized as the Japanese Pharmacopoeia Standard (Control 891).
Tanaka
M
M
Murai
M
M
Kimura
T
T
Okada
S
S
D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006077:Government Agencies; D006920:Hygiene; D010602:Pharmacopoeias as Topic; D013055:Spectrophotometry, Infrared; D014805:Vitamin B 12 / Q000302:isolation & purification / Q000592:standards*
D014805:Vitamin B 12