New pyrrolobenzodiazepine antibiotics, RK-1441A and B. II. Isolation and structure.
Antibacteriophage antibiotics, RK-1441A and B, related to neothramycin were isolated from the culture broth of Streptomyces sp. and their structures were deduced from spectroscopic analyses. The structure of RK-1441A was 8,11-dihydroxy-3,7-dimethoxy-5-oxo-1H-pyrrolo[2,1-c:1,4]benzodiazepine. RK-1441B is a tautomeric mixture at C-3 of the structure, 3,8,11-trihydroxy-7-methoxy-5-oxo-1H-pyrrolo[2,1-c:1,4]benzodiazepine.
RIKEN (The Institute of Physical and Chemical Research), Saitama, Japan.
H
H
Osada
M
M
Uramoto
J
J
Uzawa
K
K
Kajikawa
K
K
Isono
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification*; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification; D001570:Benzodiazepinones / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000378:metabolism
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D001570:Benzodiazepinones; C069060:RK 1441A; C069061:RK 1441B; C012453:neothramycins