Sublocalization of the multiple endocrine neoplasia type 1 gene.
Tumorigenesis in multiple endocrine neoplasia type 1 (MEN 1) involves the unmasking of a recessive mutation at the MEN 1 locus which has been mapped to chromosomal region 11q11-13. By analyzing 58 DNA markers on a panel of radiation-reduced somatic cell hybrids, the region encompassing the MEN 1 gene was divided into nine subregions. Pulsed field gel electrophoresis analysis of markers within subgroups showed that the recombination rate around the MEN 1 locus is high. Combined linkage analysis in MEN 1 families and deletion mapping in MEN 1-related tumors suggest the MEN 1 gene is located centromeric to D11S807 and telomeric to PYGM.
Department of Clinical Genetics, Karolinska Hospital, Stockholm, Sweden.
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C
Larsson
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G
Weber
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M
Janson
D000818:Animals; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D006224:Cricetinae; D003412:Cricetulus; D008040:Genetic Linkage; D006801:Humans; D009377:Multiple Endocrine Neoplasia / Q000235:genetics*