[Pharmacology of excitatory amino acid receptors].
L-Glutamate is an excitatory neurotransmitter at many synapses in the animal, and causes neuronal damage in the mammalian neuron. Glutamate receptors have been classified into at least five types: NMDA-, kainate-, AMPA-, and L-AP4-type ionotropic receptors and metabotropic glutamate receptors. Recently new glutamate agonists have been introduced into the pharmacological study in neuroscience research. They are methoxyphenylkainoids, acromelic acids and 2-(carboxycyclopropyl)glycine (CCG). A methoxyphenylkainoid and acromelic acid A are one of the most potent excitants in the mammalian central neuron. These compounds should provide valuable pharmacological probes for analysis of functions of excitatory amino acids.
Pharmacology Section, Tokyo Metropolitan Institute of Medical Science, Japan.
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Shinozaki
D000818:Animals; D005971:Glutamates / Q000378:metabolism / Q000502:physiology*; D018698:Glutamic Acid; D006801:Humans; D007608:Kainic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D017470:Receptors, Glutamate / Q000145:classification* / Q000378:metabolism / Q000502:physiology
D005971:Glutamates; D017470:Receptors, Glutamate; D018698:Glutamic Acid; C051743:acromelic acid A; D007608:Kainic Acid