[Ervin Neher and Bert Sakmann, 1991 Nobel Prize laureates for physiology and medicine. Ion channels and the patch clamp technic].
E. Neher and B. Sakmann were awarded the Nobel Prize for achievements in Physiology or Medicine in 1991. They developed the "patch clamp technique" which enables measurement of ionic currents through channels in the plasma membrane of living cells, and characterized their functional properties. An overview of three types of ion channels is presented: voltage gated channels, ligand gated channels and G-protein gated channels. An attempt was made to correlate their function with the structure of the protein complexes that represent ionic channels. The perforated patch clamp technique is mentioned as an alternative that enables recording of membrane currents without washing out the content of the interior of the cells.
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Fyziologický ústav CSAV, Praha.
D000818:Animals; D049673:History, 20th Century; D007473:Ion Channels; D008564:Membrane Potentials; D009613:Nobel Prize
D007473:Ion Channels
Laureáti Nobelovy ceny za fyziologii nebo lékarství za rok 1991 Ervín Neher a Bert Sakmann. Iontové kanály a technika tercíkového zámku.