Beta 2-adrenergic regulation of urea permeability of the Bufo bufo bladder.
1. Isoprenaline strongly increases the urea permeability of the bladder of Bufo bufo. This effect is due to its interaction with beta 2-adrenoreceptors, activating, in turn, the adenyl cyclase. 2. In order to ensure the regulation of urea permeability, the isoprenaline effect is present even in pathophysiological conditions, inhibiting the vasopressin action.
Lippe
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Institute of General Physiology, University of Bari, Italy.
Ardizzone
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D000225:Adenine / Q000031:analogs & derivatives / Q000494:pharmacology; D000067956:Adenylyl Cyclase Inhibitors; D000262:Adenylyl Cyclases / Q000378:metabolism; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000420:Albuterol / Q000494:pharmacology; D000818:Animals; D002023:Bufo bufo; D002463:Cell Membrane Permeability / Q000187:drug effects / Q000502:physiology*; D005280:Fenoterol / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D014508:Urea / Q000378:metabolism*
D000067956:Adenylyl Cyclase Inhibitors; D000316:Adrenergic alpha-Agonists; D000318:Adrenergic beta-Agonists; D011943:Receptors, Adrenergic, beta; C017759:9-(tetrahydro-2-furyl)-adenine; D005280:Fenoterol; D014508:Urea; D000262:Adenylyl Cyclases; D000225:Adenine; D007545:Isoproterenol; D000420:Albuterol