Retroelement particles as purification, presentation and targeting vehicles.
The manipulation of retrotransposon and retroviral particles to carry biologically active molecules is becoming feasible. In addition, recent experiments suggest that it may be possible to target these engineered particles to specific cell types. This has implications for gene therapy, biological drug delivery and vaccine design.
Virus Molecular Biology Group, Department of Biochemistry, Oxford, UK.
A J
AJ
Kingsman
S E
SE
Adams
N R
NR
Burns
S M
SM
Kingsman
D000941:Antigens / Q000235:genetics / Q000302:isolation & purification; D001709:Biotechnology; D004251:DNA Transposable Elements; D005822:Genetic Vectors; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D012190:Retroviridae / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics; D014614:Vaccines, Synthetic / Q000302:isolation & purification
D000941:Antigens; D004251:DNA Transposable Elements; D011993:Recombinant Fusion Proteins; D014614:Vaccines, Synthetic