Lack of synergism among DMAB, BOP, and MNU in induction of carcinomas of the rat ventral prostate.
The present experiment was undertaken to investigate possible synergism in induction of rat prostate tumor. F344 rats were repeatedly administered the prostate carcinogens 3,2'-dimethyl-4-aminobiphenyl (DMAB),N-nitrosobis(2-oxopropyl)amine(BOP), and N-methylnitrosourea (MNU) sequentially or together at times of hormonal castration induced regenerative cell proliferation of prostate epithelial cells. Group 1 animals received two 100 mg/kg doses of DMAB, two 20 mg/kg applications of BOP, and two times 15 mg/kg of MNU. Groups 2, 3, and 4, respectively, received each of the carcinogen treatment alone. Group 5 was given 6 applications of all three in combination, each at one-third the dose administered to the other groups. The results showed a clear synergism in enhanced tumor development in the colon but not in the prostate, in which the incidence of lesions induced by the three carcinogens was similar to that with DMAB alone.
Shirai
T
T
First Department of Pathology, Nagoya City University Medical School, Japan.
Yamamoto
A
A
Imaida
K
K
Tamano
S
S
Mori
T
T
Hasegawa
R
R
D000611:Aminobiphenyl Compounds / Q000633:toxicity*; D000818:Animals; D002273:Carcinogens; D002277:Carcinoma / Q000139:chemically induced*; D004357:Drug Synergism; D008297:Male; D008770:Methylnitrosourea / Q000633:toxicity*; D009602:Nitrosamines / Q000633:toxicity*; D011471:Prostatic Neoplasms / Q000139:chemically induced*; D051381:Rats; D011916:Rats, Inbred F344
D000611:Aminobiphenyl Compounds; D002273:Carcinogens; D009602:Nitrosamines; C001042:2',3-dimethyl-4-aminobiphenyl; C013622:nitrosobis(2-oxopropyl)amine; D008770:Methylnitrosourea