[Genotyping for drug metabolism capacity can give valuable clinical information].
There is pronounced individual variation in the human metabolism (eg, acetylation and hydroxylation) of drugs, in many cases due to genetic factors. The genetic basis of cytochrome P4502D6 gene defects has recently been elucidated, for instance. The cytochrome P4502D6 is absent from 7 percent of the Caucasian population, usually owing to the presence of either of two different mutations in the corresponding gene. PCR amplification of genomic DNA with allele-specific primers enables rapid prediction of the patient's drug metabolism capacity and the individualization of drug treatment with respect to dosage.
Institutionen för medicinsk kemi, Karolinska institutet, Stockholm.
M
M
Ingelman-Sundberg
I
I
Johansson
M L
ML
Dahl
L
L
Bertilsson
Q Y
QY
Yue
F
F
Sjöqvist
D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000378:metabolism; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010641:Phenotype; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length
D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System
Genotypning för läkemedelsmetabolisk förmåga kan ge värdefull klinisk information.