[Central analgesic action of calcitonin and its relationship with central monoamine transmitters].
The analgesic action of calcitonin (0.25 MRC units.kg-1) injected into lateral cerebral ventricle was investigated in rats. The pain threshold was evaluated by the tail-flick test. The influences of icv naloxone 5 micrograms/rat, a blocker of opiate receptor, on the analgesic action of calcitonin were observed. The results showed that icv calcitonin produced a significant analgesic action, which was reversed by naloxone. While the pain threshold was raised by calcitonin, the contents of central monoamines (5-HT, NE, DA) in brain (diencephalon, brain stem) were examined by fluorophotometry, which were increased remarkably. It is suggested that calcitonin-induced analgesia is related to the opiate receptors and the contents of 5-HT, NE, and DA in CNS.
Department of Biochemistry, Norman Bethune University of Medical Sciences, Changchun, China.
X L
XL
Yang
Y H
YH
Tang
X P
XP
Zhao
S
S
Wang
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002116:Calcitonin / Q000494:pharmacology*; D005260:Female; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D018377:Neurotransmitter Agents / Q000378:metabolism*; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012684:Sensory Thresholds / Q000187:drug effects
D000700:Analgesics; D015306:Biogenic Monoamines; D018377:Neurotransmitter Agents; D009270:Naloxone; D002116:Calcitonin