Genotoxicity of polycyclic aromatic hydrocarbons in Escherichia coli PQ37.
In the present investigation, 32 polycyclic aromatic hydrocarbons (PAHs) were tested for genotoxicity in E. coli PQ37 using the standard tube assay of the SOS chromotest. PAHs such as benzo[ghi]fluoranthene, benzo[j]fluoranthene, benzo[a]pyrene, chrysene, dibenzo[a,l]pyrene, fluoranthene and triphenylene exhibited high genotoxicity when incubated in the presence of an exogenous metabolic activation mixture. The results were compared to those obtained with the Salmonella/microsome test.
Institute of Medical Microbiology and Hygiene, Faculty of Clinical Medicine Mannheim, University of Heidelberg, F.R.G.
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Mersch-Sundermann
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Mochayedi
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Kevekordes
D000469:Alkaline Phosphatase / Q000378:metabolism; D001711:Biotransformation; D004926:Escherichia coli / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D008861:Microsomes / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D011083:Polycyclic Compounds / Q000494:pharmacology*; D013014:SOS Response, Genetics; D012486:Salmonella typhimurium / Q000187:drug effects; D013329:Structure-Activity Relationship; D001616:beta-Galactosidase / Q000378:metabolism
D009153:Mutagens; D011083:Polycyclic Compounds; D000469:Alkaline Phosphatase; D001616:beta-Galactosidase