Household-based malaria control in a highly endemic area of Africa (Tanzania): determinants of transmission and disease and indicators for monitoring--Kilombero Malaria Project.
The Kilombero Malaria Project (KMP) attempts to define operationally useful indicators of levels of transmission and disease and health system relevant monitoring indicators to evaluate the impact of disease control at the community or health facility level. The KMP is a longitudinal community based study (N = 1024) in rural Southern Tanzania, investigating risk factors for malarial morbidity and developing household based malaria control strategies. Biweekly morbidity and bimonthly serological, parasitological and drug consumption surveys are carried out in all study households. Mosquito densities are measured biweekly in 50 sentinel houses by timed light traps. Determinants of transmission and indicators of exposure were not strongly aggregated within households. Subjective morbidity (recalled fever), objective morbidity (elevated body temperature and high parasitaemia) and chloroquine consumption were strongly aggregated within a few households. Nested analysis of anti-NANP40 antibody suggests that only approximately 30% of the titer variance can be explained by household clustering and that the largest proportion of antibody titer variability must be explained by non-measured behavioral determinants relating to an individual's level of exposure within a household. Indicators for evaluation and monitoring and outcome measures are described within the context of health service management to describe control measure output in terms of community effectiveness.
Dept. Public Health & Epidemiology, Swiss Tropical Institute, Basel.
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D000818:Animals; D000852:Anopheles; D000913:Antibodies, Protozoan / Q000097:blood; D002648:Child; D016000:Cluster Analysis; D005334:Fever / Q000453:epidemiology / Q000469:parasitology; D006801:Humans; D007303:Insect Vectors; D008137:Longitudinal Studies; D008288:Malaria / Q000453:epidemiology / Q000517:prevention & control / Q000635:transmission; D016778:Malaria, Falciparum / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission; D010455:Peptides / Q000276:immunology; D010963:Plasmodium falciparum / Q000276:immunology / Q000302:isolation & purification; D011159:Population Surveillance; D012307:Risk Factors; D013636:Tanzania / Q000453:epidemiology
D000913:Antibodies, Protozoan; D010455:Peptides