Allogeneic cultured keratinocytes in the treatment of leg ulcers. A pilot study.
Forty-two patients (10 males and 32 females) with 52 chronic leg ulcers were treated with sheets of cultured allogeneic keratinocytes. Sixty-five % of the ulcers healed completely and the healing rate differed between various diagnostic groups. The best results were obtained in patients with venous ulcers and wounds with mixed etiology, whereas less improvement was observed with ischaemic ulcers. Rheumatic ulcers also responded well in combination with oral corticosteroids. The overall impression was that the grafting procedure markedly enhanced wound healing.
Center for BioTechnology, Karolinska Institute, NOVUM, Huddinge, Sweden.
J A
JA
Marcusson
C
C
Lindgren
A
A
Berghard
R
R
Toftgård
D000368:Aged; D000369:Aged, 80 and over; D002478:Cells, Cultured; D002908:Chronic Disease; D005260:Female; D006801:Humans; D015603:Keratinocytes / Q000637:transplantation*; D007871:Leg Ulcer / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D014945:Wound Healing