Protein hormones and their receptors.
Technological advances in the isolation and characterization of novel receptors have led to a significant increase in our understanding of protein-ligand binding to receptors and the means by which responses are triggered. Hormones and their receptors are composed of structurally conserved domains, and several ligands appear to use similar surface regions for receptor binding. A key event in signal transduction is the aggregation by the ligand of one or more receptor subunits, and this can include the sharing of subunits between different ligands. These findings have allowed the design of ligands with receptor-antagonist properties.
Department of Molecular Genetics/L-48, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406-0939.
P R
PR
Young
D006728:Hormones / Q000737:chemistry / Q000378:metabolism*; D011487:Protein Conformation; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015398:Signal Transduction; D013329:Structure-Activity Relationship
D006728:Hormones; D011956:Receptors, Cell Surface