Chondroitin sulphate and peritoneal permeability.
We studied the effect of chronic intraperitoneal (ip) infusion of saline supplemented with the glycosaminoglycan-chondroitin sulphate 0.1% on the permeability and peroxidation of the peritoneal membrane in rats and compared this with the effect of saline infusion alone. Animals treated with chondroitin sulphate had a higher net ultrafiltration (uf), a slower glucose absorption from the dialysate and less trans-peritoneal loss of proteins. Chronic ip infusion of chondroitin sulphate reduced peroxidation of the peritoneum. These observations suggest that chondroitin may effect the peritoneal interstitium-an important barrier of fluid and solutes transport.
Breborowicz
A
A
Department of Pathophysiology, Medical Academy Poznan, Poland.
Wieczorowska
K
K
Knapowski
J
J
Martis
L
L
Serkes
K D
KD
Oreopoulos
D G
DG
D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D002809:Chondroitin Sulfates / Q000008:administration & dosage / Q000493:pharmacokinetics*; D015314:Dialysis Solutions / Q000032:analysis; D005947:Glucose / Q000032:analysis; D008315:Malondialdehyde / Q000378:metabolism; D010530:Peritoneal Dialysis; D010537:Peritoneum / Q000378:metabolism*; D010539:Permeability; D051381:Rats; D017208:Rats, Wistar; D014462:Ultrafiltration; D014508:Urea / Q000032:analysis
D001798:Blood Proteins; D015314:Dialysis Solutions; D008315:Malondialdehyde; D014508:Urea; D002809:Chondroitin Sulfates; D005947:Glucose