[Enhancing effect of L-histidine on the formation of 8-hydroxy-deoxyguanosine induced by hydrogen peroxide in vitro].
Treatment of deoxyguanosine with H2O2 (56 mM) at 37 degrees C for 2 hrs resulted in the formation of 8-hydroxydeoxyguanosine (8-OH-dG). The formation of 8-OH-dG by H2O2 was increased about 3-folds in the presence of 78 microM L-histidine (L-His). The result suggests that oxidative DNA damage induced by H2O2 in vitro might be enhanced by L-His.
Takagi
A
A
Sai
K
K
Hasegawa
R
R
Kurokawa
Y
Y
D000080242:8-Hydroxy-2'-Deoxyguanosine; D002478:Cells, Cultured; D004249:DNA Damage / Q000187:drug effects; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000096:biosynthesis; D004357:Drug Synergism; D005347:Fibroblasts / Q000378:metabolism; D006639:Histidine / Q000494:pharmacology*; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*
D006639:Histidine; D000080242:8-Hydroxy-2'-Deoxyguanosine; D006861:Hydrogen Peroxide; D003849:Deoxyguanosine