Immunopathophysiology of gastrointestinal disease in HIV infection.
In summary, gastrointestinal manifestations are a major complication of HIV infection. These manifestations present clinically as early, intermediate, and late-phase enteric illness due to HIV itself or the acquisition of opportunistic infections and neoplasms. HIV-induced defects in lymphocytes and mononuclear phagocytes, which circulate through and populate the gastrointestinal mucosa, and a sequence of HIV-dependent alterations in mucosal integrity represent the fundamental immunopathophysiologic basis for these clinical manifestations.
Smith
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Cellular Immunology Section, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland.
Mai
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D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D005767:Gastrointestinal Diseases / Q000150:complications / Q000276:immunology*; D005770:Gastrointestinal Neoplasms / Q000209:etiology / Q000276:immunology; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology / Q000382:microbiology; D008262:Macrophage Activation; D009894:Opportunistic Infections / Q000150:complications / Q000276:immunology*; D012514:Sarcoma, Kaposi / Q000209:etiology / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology