[The expansion of NK CD56+ cells with reduced cytotoxicity in a female patient with systemic sclerosis].
An absolute and relative increase of circulating CD56+ (NKH1, Leu19) natural killer cells has been found in a patient with systemic sclerosis. The expanded natural killer cells exhibited reduced natural killer activity and antibody-dependent cell-mediated cytotoxicity. Furthermore, the limiting dilution analysis of spontaneous in vitro immunoglobulin synthesis demonstrated that the precursor frequency of immunoglobulin-secreting cells and the "single-hit" kinetics of the titration curve were similar to healthy controls, but strongly different from previously reported patients in whom CD16+NK cell subset was expanded. Thus, our findings might suggest that expanded CD56+ natural killer cells exhibit unique regulatory properties on B cell function in systemic sclerosis.
Istituto di Clinica medica, Università, L'Aquila.
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Famularo
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Quintieri
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A
D'Ambrosio
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F
Pizzuto
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R
Giacomelli
O
O
Pugliese
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G
Tonietti
D000368:Aged; D000920:Antibody-Dependent Cell Cytotoxicity / Q000276:immunology*; D015703:Antigens, CD / Q000097:blood*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000097:blood*; D019002:CD56 Antigen; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis; D007694:Killer Cells, Natural / Q000276:immunology*; D007958:Leukocyte Count; D012595:Scleroderma, Systemic / Q000276:immunology*
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D019002:CD56 Antigen; D007136:Immunoglobulins
Espansione delle cellule NK CD56+ con ridotta citotossicità in una paziente affetta da sclerosi sistemica.