Principles and methods of medicamentous protection of myocardial cellular membranes for prevention of cardiac reperfusion syndrome.
A model of regional transitory coronary insufficiency was employed in experiments on 300 male albino rats under urethan anaesthesia (13.4 mmol/kg b.m.). The periods of myocardial ischaemia lasted 10, 40 and 120 min, followed by reperfusion lasting 40 min. The alteration of cellular membrane apparatus proved to be one of the most important mechanisms responsible for myocardial lesion during transitory coronarogenic ischaemia and for the development of cardiac reperfusion syndrome. The damage to cardiomyocyte membrane and intensity of reperfusion syndrome can be substantially reduced by using the following measures: inhibition of lipoperoxidation by antioxidative preparations, esp. myofedrin and verapamil; suppression of the intensity of phospholipase reactions activated by Ca2+; reduction of calcium ion accumulation in cardiomyocytes by substances lowering intracellular calcium content, esp. by verapamil.
Department of Pathological Physiology, I. M. Sechenov Moscow Medical Academy, Russia.
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Litvitskii
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects* / Q000502:physiology; D002462:Cell Membrane / Q000187:drug effects* / Q000502:physiology; D003402:Creatine Kinase / Q000097:blood; D007527:Isoenzymes; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008563:Membrane Lipids / Q000502:physiology; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology / Q000517:prevention & control*; D051381:Rats; D012643:Selenium / Q000494:pharmacology*; D018038:Sodium Selenite
D000318:Adrenergic beta-Agonists; D000975:Antioxidants; D002121:Calcium Channel Blockers; D015220:Calcium Channels; D007527:Isoenzymes; D008563:Membrane Lipids; D003402:Creatine Kinase; D012643:Selenium; D018038:Sodium Selenite; D002118:Calcium