Long-term follow-up of childhood Henoch-Schönlein nephritis.
A study of long-term outcome of 78 subjects who had had Henoch-Schönlein nephritis during childhood (at a mean of 23.4 years after onset) shows that severity of clinical presentation and initial findings on renal biopsy correlate well with outcome but have poor predictive value in individuals. 44% of patients who had nephritic, nephrotic, or nephritic/nephrotic syndromes at onset have hypertension or impaired renal function, whereas 82% of those who presented with haematuria (with or without proteinuria) are normal. 17 patients deteriorated clinically from an initial assessment in 1971; 7 of these had apparently completely recovered in 1976. 16 of 44 full-term pregnancies were complicated by proteinuria and/or hypertension, even in the absence of active renal disease. These findings indicate that childhood Henoch-Schönlein nephritis requires long-term follow-up, especially during pregnancy.
Department of Nephrology, Children's Hospital, Birmingham, UK.
A R
AR
Goldstein
R H
RH
White
R
R
Akuse
C
C
Chantler
D001706:Biopsy; D002648:Child; D003404:Creatinine / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D011695:IgA Vasculitis / Q000097:blood / Q000150:complications* / Q000473:pathology / Q000652:urine; D007668:Kidney / Q000473:pathology; D008297:Male; D009393:Nephritis / Q000097:blood / Q000209:etiology* / Q000473:pathology / Q000652:urine; D012075:Remission, Spontaneous; D013997:Time Factors
D003404:Creatinine