Molecular studies on trypanothione reductase: an antiparasitic target enzyme.
Walsh
C
C
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115.
Bradley
M
M
Nadeau
K
K
D000595:Amino Acid Sequence; D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology; D001665:Binding Sites; D014355:Chagas Disease / Q000453:epidemiology; D003421:Crithidia / Q000201:enzymology; D015195:Drug Design; D005978:Glutathione / Q000031:analogs & derivatives* / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D007891:Leishmania / Q000201:enzymology; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010084:Oxidation-Reduction; D015995:Prevalence; D015202:Protein Engineering; D015800:Protozoan Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D013095:Spermidine / Q000031:analogs & derivatives* / Q000378:metabolism; D013379:Substrate Specificity; D014345:Trypanosoma / Q000201:enzymology*; D014348:Trypanosoma congolense / Q000201:enzymology / Q000235:genetics; D014353:Trypanosomiasis, African / Q000453:epidemiology
D000981:Antiprotozoal Agents; D015800:Protozoan Proteins; C044809:trypanothione; D009247:NADH, NADPH Oxidoreductases; C049608:trypanothione reductase; D005980:Glutathione Reductase; D005978:Glutathione; D013095:Spermidine