IgG monoclonal proteins from patients with axonal peripheral neuropathies bind to different epitopes of the 68 kDa neurofilament protein.
We describe three patients with a sensorimotor axonal polyneuropathy and an IgG M-protein that binds to a 68 kDa axonal protein identified as the low molecular weight neurofilament protein (NF-L). The immunological studies revealed that the M-proteins have different target epitopes: one is phosphorylated and the other two are nonphosphorylated. One of the nonphosphorylated epitopes is common to other intermediate filaments, such as desmin and vimentin.
Fazio
R
R
Department of Neurology, University of Milan, Italy.
Nemni
R
R
Quattrini
A
A
Lorenzetti
I
I
Canal
N
N
D001369:Axons / Q000276:immunology*; D001798:Blood Proteins / Q000276:immunology*; D000939:Epitopes / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology*; D007136:Immunoglobulins; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D016900:Neurofilament Proteins / Q000276:immunology*; D010523:Peripheral Nervous System Diseases / Q000276:immunology* / Q000473:pathology; D010766:Phosphorylation
D001798:Blood Proteins; D000939:Epitopes; D007074:Immunoglobulin G; D007136:Immunoglobulins; C009823:M-proteins (Myeloma); D016900:Neurofilament Proteins