[Problems in multidisciplinary treatment from the standpoint of clinical characteristics in human cancers].
We investigated the amplification and expression of oncogenes in human gastric and breast cancers. The biological malignancy of the cases with oncogene amplification/expression was higher than that of the cases without amplification/expression. Moreover, the case with amplification/expression of oncogene was found to be highly correlated with distant organ metastasis. In strongly suggests the necessity of postoperative adjuvant therapy. In addition, these data will have to be taken into consideration as deciding on the way of operation and therapy.
Kikuchi
K
K
Department of Surgery, Tokyo Deneyoku Hospital, Japan.
Ueda
M
M
Fujisaki
M
M
Watanabe
M
M
Tsuyuki
A
A
Fujishiro
Y
Y
Kitajima
M
M
D001943:Breast Neoplasms / Q000235:genetics / Q000401:mortality / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D051518:Fibroblast Growth Factor 3; D005346:Fibroblast Growth Factors; D005784:Gene Amplification; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009857:Oncogenes; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000032:analysis; D018719:Erb-b2 Receptor Tyrosine Kinases; D013274:Stomach Neoplasms / Q000235:genetics / Q000401:mortality / Q000628:therapy*; D015996:Survival Rate
D051518:Fibroblast Growth Factor 3; D005346:Fibroblast Growth Factors; D011518:Proto-Oncogene Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; C496444:FGF3 protein, human