Studies of nonsedative antihistamines. II. Assessment of its antihistaminic potency.
An analysis is made of the effectiveness of terfenadine at dosages of 60 and 120 mg, of cetirizine at a dose of 10 mg, and of loratadine and ebastine at a dose of 10 mg in inhibiting the papule induced by 20 mcg of intradermal histamine. Although all produced significant inhibition, cetirizine and terfenadine 120 mg showed a significantly greater inhibition coefficient than loratadine.
Hospital de la Santa Creu i Sant Pau, Unitat d'Al.lèrgia, Barcelona.
S
S
Aparicio
C
C
Granel
L
L
Randazzo
M
M
Valencia
A
A
Olivé Pérez
D000328:Adult; D002090:Butyrophenones / Q000008:administration & dosage / Q000494:pharmacology; D017332:Cetirizine / Q000008:administration & dosage / Q000494:pharmacology; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006632:Histamine; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007428:Intradermal Tests; D017336:Loratadine / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology; D011897:Random Allocation; D016593:Terfenadine / Q000008:administration & dosage / Q000494:pharmacology
D002090:Butyrophenones; D006634:Histamine H1 Antagonists; D010880:Piperidines; D017336:Loratadine; D016593:Terfenadine; D006632:Histamine; C058249:ebastine; D017332:Cetirizine