Neurotransmitter transporters. A novel family of integral plasma membrane proteins.
The re-uptake of neurotransmitters into the nerve terminal terminates synaptic transmission at most central synapses and constitutes a key step in the modulation of synaptic efficacy. Recently, the cloning of several Na(+)-driven neurotransmitter transporters has resulted in the description of a novel family of homologous membrane proteins, each with 12 transmembrane segments. These transporters constitute major targets of widely used drugs, and modulation of transporter gene expression and/or activity may represent an important substrate for plasticity in the nervous system.
Abteilung Neurochemie, Max-Planck-Institut für Hirnforschung, Frankfurt/M. Germany.
P
P
Schloss
W
W
Mayser
H
H
Betz
D000595:Amino Acid Sequence; D000818:Animals; D001692:Biological Transport; D002352:Carrier Proteins / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D008969:Molecular Sequence Data; D018377:Neurotransmitter Agents / Q000378:metabolism*; D016415:Sequence Alignment
D002352:Carrier Proteins; D008565:Membrane Proteins; D018377:Neurotransmitter Agents