New classes of selective D-1 dopamine receptor antagonist provide further evidence for two directions of D-1:D-2 interaction.
Initial notions of cooperative/synergistic interactions between D-1 and D-2 dopamine receptors have been followed by recent evidence suggesting more complex forms of D-1:D-2 interaction. Each of the new, putative selective D-1 antagonists SCH 39166, NO 756 and A-69024 antagonised typical behavioural responses to the selective D-2 agonist RU 24213 and concurrently released atypical behaviour. These data extend new notions of both cooperative/synergistic and oppositional D-1:D-2 interactions in the regulation of typical and atypical behaviours, which may involve further subtypes of D-1 and of D-2 receptor.
Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin.
S A
SA
Daly
J L
JL
Waddington
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D018491:Dopamine Agonists / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000145:classification*; D006801:Humans; D010627:Phenethylamines / Q000494:pharmacology; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors* / Q000502:physiology*; D017448:Receptors, Dopamine D2 / Q000502:physiology*
D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D010627:Phenethylamines; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; C016868:N-n-propyl-N-phenylethyl-4(3-hydroxyphenyl)ethylamine hydrochloride