[Study on adrenergic acid secretion using isolated parietal cells of guinea-pigs].
In order to investigate the effect of adrenergic nerve system on acid secretion at the cell-levels, acid secretion of isolated parietal cells stimulated by various adrenergic agonists was observed by measuring the accumulation of 14C-aminopyrine (A.P.). Both isoproterenol, beta receptor agonist, and salbutamol, beta-2 receptor selective agonist, increased A.P. accumulation, whereas dobutamine, beta-1 receptor selective agonist, showed no effect. And beta-2 receptor on parietal cells was detected by binding assay. These data may suggest that parietal cells have beta-2 receptors through which acid secretion will occur.
Department of Internal Medicine 6, Tokai University School of Medicine.
M
M
Miyazawa
N
N
Tani
T
T
Miwa
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000632:Aminopyrine / Q000378:metabolism; D000818:Animals; D002478:Cells, Cultured; D005744:Gastric Acid / Q000378:metabolism*; D006168:Guinea Pigs; D008297:Male; D010295:Parietal Cells, Gastric / Q000187:drug effects / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism
D000318:Adrenergic beta-Agonists; D011943:Receptors, Adrenergic, beta; D000632:Aminopyrine