Protactin, a new antibiotic metabolite and a possible precursor of the actinomycins.
Streptomyces cucumerosporus strain L703-4 (ATCC 53784) produces a new 4-methyl-3-hydroxyanthraniloylpentapeptide lactone for which we have proposed the name protactin, in addition to several actinomycin components. Protactin is rather resistant to air oxidation but it can be converted to a new actinomycin, actinomycin Zp by ferricyanide oxidation. Actinomycin Zp possesses in vitro antibacterial activity and in vivo antitumor activity against P-388 leukemia in mice.
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
M
M
Hanada
K
K
Sugawara
Y
Y
Nishiyama
H
H
Kamei
M
M
Hatori
M
M
Konishi
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002277:Carcinoma / Q000188:drug therapy; D002855:Chromatography, Thin Layer; D015179:Colorectal Neoplasms / Q000188:drug therapy; D003609:Dactinomycin / Q000096:biosynthesis* / Q000494:pharmacology; D005260:Female; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D006801:Humans; D006868:Hydrolysis; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009842:Oligopeptides / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D000596:Amino Acids; D000903:Antibiotics, Antineoplastic; D009842:Oligopeptides; C073533:protactin; D003609:Dactinomycin