Measuring and increasing protein stability.
Recently, it has become possible to construct proteins to order and this has promoted interest in learning how to increase their stability. This article describes recent developments in the methods used to measure the conformational stability of globular proteins, and discusses the approaches being used to increase their stability.
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Biochemistry Department, Texas A&M University, College Station 77843.
D005916:Globulins / Q000235:genetics* / Q000378:metabolism; D009154:Mutation; D011487:Protein Conformation; D011489:Protein Denaturation; D015202:Protein Engineering; D006163:Ribonuclease T1 / Q000235:genetics / Q000378:metabolism; D013816:Thermodynamics
D005916:Globulins; D006163:Ribonuclease T1