Abnormalities of lymphocyte function and phenotypic pattern in a case of toxic epidermal necrolysis.
We examined the blood lymphocyte function and phenotypic pattern in a patient with toxic epidermal necrolysis after taking salazopyrin. We studied cell surface markers, natural killer cell activity and mitogen-induced lymphocyte transformation. Our results point to temporary immunosuppression as evidenced by lymphopenia with a large "null cell" population, reduced natural killer cell activity, and impaired lymphocyte response to mitogens.
Department of Dermatology, Odense University Hospital, Denmark.
H
H
Hagdrup
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Tønnesen
O
O
Clemmensen
K E
KE
Andersen
D000208:Acute Disease; D000328:Adult; D002452:Cell Count; D006801:Humans; D016130:Immunophenotyping; D016131:Lymphocyte Subsets / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D013262:Stevens-Johnson Syndrome / Q000276:immunology* / Q000473:pathology