Marrow fibrosis associated with a Philadelphia chromosome.
Three patients had marked marrow fibrosis and an apparent Philadelphia (Ph) chromosome. Hematologic, cytogenetic, and molecular studies demonstrated the heterogeneity of such cases, including the first example of clinically typical myelofibrosis (MF) associated with a bcr gene rearrangement characteristic of chronic myelogenous leukemia (CML).
Nowell
P C
PC
Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia 19104-6082.
Kant
J A
JA
Finan
J B
JB
Cassileth
P A
PA
Hanson
C A
CA
D001853:Bone Marrow / Q000473:pathology*; D016026:Bone Marrow Transplantation; D005260:Female; D005355:Fibrosis; D006801:Humans; D007372:Interferons / Q000627:therapeutic use; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010677:Philadelphia Chromosome; D055728:Primary Myelofibrosis / Q000235:genetics* / Q000473:pathology / Q000628:therapy
D007372:Interferons