Serum levels of vitamin D metabolites in isotretinoin-treated acne patients.
Serum levels of vitamin D metabolites were determined in 11 patients treated for cystic acne with a four-month course of isotretinoin (Roaccutane). The levels were measured before treatment and after two months of medication. We found a significant fall in the level of 1,25-dihydroxyvitamin D (p less than 0.01) and a significant increase in the molar ratio of 24, 25-dihydroxyvitamin D to 25-hydroxyvitamin D (p less than 0.05). No significant changes were found for the vitamin D metabolites 25-hydroxyvitamin D or 24,25-dihydroxy-vitamin D, for serum calcium, phosphorus, alkaline phosphatase or parathyroid hormone. Our data indicate early changes in the metabolism of vitamin D in patients on retinoid treatment.
Department of Dermatology, University of Bergen, Haukeland Hospital, Norway.
O
O
Rødland
L
L
Aksnes
A
A
Nilsen
T
T
Morken
D000152:Acne Vulgaris / Q000097:blood* / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D002112:Calcifediol / Q000097:blood*; D002118:Calcium / Q000097:blood; D004872:Ergocalciferols / Q000097:blood*; D005260:Female; D006801:Humans; D015474:Isotretinoin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D004872:Ergocalciferols; C003564:1,25-dihydroxyergocalciferol; C028140:24,25-dihydroxyvitamin D2; D015474:Isotretinoin; D002112:Calcifediol; D002118:Calcium