A low protein-high carbohydrate diet decreases D2 dopamine receptor density in rat brain.
The property of D2 dopamine receptors in the rat brain was evaluated after long-term dietary manipulation. Groups of rats were pair-fed with equicaloric diet containing low protein (8%)-high carbohydrate, high protein (52%)-low carbohydrate and normal protein (20%) for 36 weeks. The low protein-high carbohydrate fed rats exhibited a significant decrease in the density (Bmax) of D2 dopamine receptor in the striatum (28%) and the mesolimbic regions (36%) with no apparent change in the receptor affinity (Kd). These findings suggest that long-term consumption of a low protein-high carbohydrate diet, by decreasing D2 dopamine receptor density, may be an important determinant of central dopaminergic function.
Laboratory of Neurosciences, Pennington Biomedical Research Center, Baton Rouge, LA 70808.
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Hamdi
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Onaivi
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Prasad
D000818:Animals; D014150:Antipsychotic Agents / Q000378:metabolism; D001549:Benzamides / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004044:Dietary Proteins / Q000008:administration & dosage*; D008297:Male; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000378:metabolism*; D017448:Receptors, Dopamine D2
D014150:Antipsychotic Agents; D001549:Benzamides; D004040:Dietary Carbohydrates; D004044:Dietary Proteins; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; C030265:nemonapride