T cell receptor gamma variable gene locus polymorphism in patients with rheumatoid arthritis.
OBJECTIVE
We sought new susceptibility markers for rheumatoid arthritis (RA) among the T cell receptor gamma (TCR gamma) genes.


METHODS
We analyzed restriction fragment length polymorphisms (RFLP) of the first variable subgroup of TCR gamma genes in a group of French control subjects and a group of French RA patients.


RESULTS
No significant difference in Eco RI RFLP was found between the 2 study populations: Allele frequencies were virtually identical. There was no polymorphism using Hind III.


CONCLUSIONS
These results exclude TCRV gamma I polymorphism as a disease susceptibility marker in RA.
Chaouni
I
I
INSERM U291, Montpellier, France.
Lefranc
M P
MP
d'Angeac
A D
AD
Zanin
C
C
Pellet
F
F
Clot
J
J
Combe
B
B
Sany
J
J
Rème
T
T
D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000276:immunology; D015139:Blotting, Southern; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics*; D012016:Reference Values
D016692:Receptors, Antigen, T-Cell, gamma-delta