Antibody geometry and form: three-dimensional relationships between anti-idiotypic antibodies and external antigens.
Anti-idiotypes have been developed to mimic a wide variety of antigens in studies of antibody-antigen interactions. Molecular, biochemical and structural analysis of antibody-anti-idiotype pairs presents an excellent model for study of complex protein-protein interactions. An understanding of the ways in which anti-idiotypes mimic antigens and the features determining binding characteristics will facilitate rational design of compounds with biological, enzymatic, pharmaceutical and chemical applications.
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-4283.
W V
WV
Williams
D B
DB
Weiner
T
T
Kieber-Emmons
M I
MI
Greene
D000595:Amino Acid Sequence; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000737:chemistry / Q000276:immunology*; D000937:Antigen-Antibody Reactions; D000941:Antigens / Q000737:chemistry / Q000276:immunology*; D001666:Binding Sites, Antibody / Q000276:immunology; D006241:Haptens / Q000276:immunology; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011506:Proteins / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D000941:Antigens; D006241:Haptens; D011506:Proteins