[The pharmacological regulation of neutrophil activity by cholinotropic preparations, barbiturates and fenazepam].
The in vitro experiments with human blood cells and in vivo experiments on Wistar rats have demonstrated that stimulation of neutrophils enhances their phagocytic metabolic activity. Barbiturates (benzonal and phenobarbital) and phenazepam in low concentrations (doses) increase neutrophilic function evaluated by the NBT test, but in high ones cause opposite effects.
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Zabrodskiĭ
D000328:Adult; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001463:Barbiturates / Q000494:pharmacology*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D066298:In Vitro Techniques; D009504:Neutrophils / Q000187:drug effects* / Q000201:enzymology; D009580:Nitroblue Tetrazolium; D010277:Parasympathomimetics / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
D014151:Anti-Anxiety Agents; D001463:Barbiturates; D001570:Benzodiazepinones; D010277:Parasympathomimetics; D001569:Benzodiazepines; D009580:Nitroblue Tetrazolium; C017928:phenazepam
Farmakologicheskaia reguliatsiia aktivnosti neĭtrofilov kholinotropnymy preparatami, barbituratami i fenazepamom.