Energy metabolism and effects of energy depletion or exposure to glutamate.
The entire program of the first day of the IBRO satellite meeting entitled Ions, Water, and Energy in Brain Cells was devoted to the subject of energy. There were three sessions on the topics of energy metabolism, activation, and development and pathological conditions, followed by a final general discussion on the contents of the day's topics. During this general discussion there were spirited exchanges on the role of glycogen in the energy metabolism of the brain, on the metabolic source of the energy consumed by functional activity, e.g., glycolytic or oxidative energy metabolism, and on the sources of the acid-equivalents that are responsible for the tissue acidosis accompanying cerebral hypoxia. Despite the arguments pro and con presented on all of the issues that were discussed, it is doubtful that a consensus was achieved on most of the issues.
Sokoloff
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Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, MD 20892.
D000818:Animals; D004734:Energy Metabolism / Q000502:physiology*; D005971:Glutamates / Q000494:pharmacology*; D018698:Glutamic Acid; D006801:Humans
D005971:Glutamates; D018698:Glutamic Acid