Effect of LY 171555 and CY 208-243 on tremor suppression in the MPTP monkey model of parkinsonism.
The antitremor effect of the D2 agonist LY 171555 and of the D1 agonist CY 208-243 alone and in combination was tested in a monkey previously rendered parkinsonian by MPTP and displaying exceptionally a rest tremor in the limbs. The D2 agonist suppressed rest tremor in a dose-dependent fashion. The D1 agonist by itself had no effect but it potentiated the effect of a small dose of LY 171555.
Centre de Recherche en Neurobiologie, Hôpital de l'Enfant-Jésus, Québec, Canada.
B
B
Gomez-Mancilla
R
R
Boucher
P J
PJ
Bédard
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D015259:Dopamine Agents / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004576:Electromyography; D004873:Ergolines / Q000627:therapeutic use*; D005260:Female; D007211:Indoles / Q000627:therapeutic use*; D007279:Injections, Subcutaneous; D008252:Macaca fascicularis; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000188:drug therapy*; D010617:Phenanthridines / Q000627:therapeutic use*; D019257:Quinpirole; D014202:Tremor / Q000139:chemically induced / Q000188:drug therapy*
D000978:Antiparkinson Agents; D015259:Dopamine Agents; D004873:Ergolines; D007211:Indoles; D010617:Phenanthridines; C054531:CY 208-243; D019257:Quinpirole; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine