Lack of acipimox-digoxin interaction in patient volunteers.
1. A study was carried out to find out if digoxin and acipimox interact. 2. Six elderly patients on digoxin were each given acipimox 150 mg three daily for a week, after informed consent. Digoxin and acipimox plasma concentrations and urinary excretion were measured after the first dose of acipimox and after a week of treatment. 3. Data were fitted to a one-compartment oral absorption model. Areas under the plasma concentration-time curve, plasma and renal clearances, and elimination half-life were computed. 4. There was no significant difference in digoxin plasma concentrations and kinetic parameters before and after acipimox administration. Acipimox kinetics were not affected by the concomitant ingestion of digoxin. 5. The patients' clinical condition remained stable during the study. 6. Thus there was no evidence for an adverse interaction between digoxin and acipimox in human subjects under the conditions of this study.
Chijioke
C P
CP
Department of Clinical Pharmacology, St Bartholomew's Hospital, West Smithfield, London, UK.
Pearson
R M
RM
Benedetti
S
S
D000368:Aged; D000369:Aged, 80 and over; D004077:Digoxin / Q000493:pharmacokinetics*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D000960:Hypolipidemic Agents / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D011719:Pyrazines / Q000493:pharmacokinetics*
D000960:Hypolipidemic Agents; D011719:Pyrazines; D004077:Digoxin; C027696:acipimox