Novel agents that promote bone regeneration.
Regulation of bone growth is controlled partly by local growth factors, which have effects on bone including the differentiation of precursor cells, osteoblast proliferation, the stimulation of matrix synthesis and angiogenesis. These factors are hypothesized to have a role in augmenting bone repair. In the past year, recombinant technology has provided sufficient material to allow extensive in vivo evaluation of this hypothesis.
Schaub
R G
RG
Genetics Institute Inc., Cambridge, Massachusetts.
Wozney
J
J
D000818:Animals; D019485:Bone Morphogenetic Proteins; D001861:Bone Regeneration / Q000502:physiology*; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D011506:Proteins / Q000235:genetics / Q000502:physiology*; D011994:Recombinant Proteins
D019485:Bone Morphogenetic Proteins; D006133:Growth Substances; D011506:Proteins; D011994:Recombinant Proteins