The Mouse Genome Project and human genetics. A report from the 5th International Mouse Genome Mapping Workshop, Lunteren, Holland.
Genome-wide mapping efforts are moving toward the establishment of a 1-cM genetic map of the entire mouse genome. The bulk of linkage groups conserved between the mouse and the human genomes has been identified. Microsatellite mapping has had a major impact on the development of genome-wide genetic maps and, in particular, on genome-wide searches for polygenic disease loci. Some substantial regions of the mouse genome have a marker density of 1 cM or less and many of these regions are now physically mapped. Embryonic YAC contigs have been established in some physically mapped regions. A unitary, global mouse mapping database--the Mouse Genome Database--is under development along with associated software tools. Chromosome committees are having a major impact on the establishment and verification of chromosome maps through the preparation of published annual reports.
Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, London, United Kingdom.
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D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004274:DNA, Recombinant; D004276:DNA, Satellite / Q000032:analysis; D016208:Databases, Factual; D005819:Genetic Markers; D015698:Genomic Library; D016045:Human Genome Project; D006801:Humans; D008322:Mammals / Q000235:genetics; D051379:Mice / Q000235:genetics*; D012376:Rodent Diseases / Q000235:genetics
D004274:DNA, Recombinant; D004276:DNA, Satellite; D005819:Genetic Markers