Estimation of elastic recovery, work of decompression and Young's modulus using a rotary tablet press.
Capping and lamination occur when the bonds within a tablet cannot withstand the elastic recovery during decompression. To estimate tablet recovery, it is necessary to subtract the machine recovery from the total recovery during decompression. A direct relationship between the force and machine deformation is applied in a novel fashion to calculate in-die tablet recovery on a Manesty Betapress and to estimate the Young's modulus, E, of various solids from the recovery data. The E values of about twenty-five pharmaceutical solids were found to be in reasonable agreement with literature values. This procedure allows in-process analysis of tablet recovery and gives E without the use of specialized equipment.
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
S K
SK
Dwivedi
R J
RJ
Oates
A G
AG
Mitchell
D000465:Algorithms; D013607:Tablets; D013678:Technology, Pharmaceutical
D013607:Tablets