[Prevention and treatment of digestive hemorrhage due to ruptured esophageal varices in patients with cirrhosis].
1) Emergency treatment. The best treatment remains endoscopic sclerotherapy, which controls the bleeding in 90% of the cases. Pharmacologic management stops the variceal hemorrhage in 80% of the cases and is indicated before endoscopic treatment can be performed. Intravenous somatostatin administration may be prolonged for 5 days, even more, and may thus prevent early rebleeding, which is not achieved neither by vasopressin nor by glypressin, which administration is restricted to 24 hours. Esophageal tamponade is useful to arrest a massive variceal bleeding, if vasoactive drugs are not available or not efficient, before endoscopic management. If the bleeding persists after 2 sclerotherapy sessions, an alternative treatment is mandatory: the patient should be sent to the surgeon for a portosystemic shunt if the operative risk is acceptable (child A and B) or should become a candidate for a transjugular intrahepatic stent shunt, especially if transplantation is considered afterwards. 2) Prevention of recurrent hemorrhage. A) Early (within 5 days after the initial bleeding). Somatostatin probably prevents early rebleeding, as do sclerotherapy. B) Late. B blockade (+ nitrates) or long-term sclerotherapy have the same efficacy. Their association may improve their results. 3) Prevention of the first bleeding episode. Propranolol decrease the risk of variceal rupture from 20% to 9% during the first year after the diagnosis of esophageal varices and is the only treatment which may be proposed to cirrhotics who did not yet bled form their varices.
Service Médico-Chirurgical de Gastroentérologie, ULB, Hôpital Erasme, Bruxelles, Belgique.
N
N
Bourgeois
F
F
Bourgeois
O
O
Le Moine
J
J
Van de Stadt
M
M
Adler
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D021721:Balloon Occlusion; D002404:Catheterization; D016145:Endoscopy, Digestive System; D004932:Esophageal and Gastric Varices / Q000150:complications*; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D011170:Portasystemic Shunt, Surgical; D012422:Rupture, Spontaneous; D015911:Sclerotherapy; D012702:Serotonin Antagonists / Q000627:therapeutic use; D014662:Vasoconstrictor Agents / Q000627:therapeutic use
D000319:Adrenergic beta-Antagonists; D012702:Serotonin Antagonists; D014662:Vasoconstrictor Agents
Prévention et traitement de l'hémorragie digestive sur rupture de varices oesophagiennes chez le patient cirrhotique.