Changes in dopamine D1, D2 and D3 receptor mRNA levels in rat brain following antipsychotic treatment.
The effects of administration of antipsychotic drugs (1-32 days, twice per day) on the rat brain mRNA levels of dopamine D1, D2 and D3 receptors has been assessed by a novel procedure utilising solution hybridisation with oligonucleotides. Saline and sulpiride (10 mg/kg/injection) had no effect on D1, D2 and D3 receptor mRNA levels. Haloperidol (1.5 mg/kg/injection) elicited increases in D1, D2 and D3 receptor mRNA levels of 100%, 100% and 300% respectively, after 32 days and loxapine (2 mg/kg/injection) elicited increases of 450%, 150% and 550%, respectively. These results indicate that the up-regulation of dopamine receptors may be associated with the occurrence of tardive dyskinesia but not the clinical mode of action of antipsychotics.
Buckland
P R
PR
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK.
O'Donovan
M C
MC
McGuffin
P
P
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D015152:Blotting, Northern; D001923:Brain Chemistry / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology; D008152:Loxapine / Q000494:pharmacology; D008297:Male; D009841:Oligonucleotides; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000096:biosynthesis*; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D013469:Sulpiride / Q000494:pharmacology
D014150:Antipsychotic Agents; C493595:Drd3 protein, rat; D009841:Oligonucleotides; D012333:RNA, Messenger; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D013469:Sulpiride; D006220:Haloperidol; D008152:Loxapine