Schizophrenia and porphobilinogen deaminase gene polymorphisms: an association study.
A genetic case-control study was conducted in a group of patients with schizophrenia (n = 67; DSM-III) and psychiatrically normal controls matched for ethnicity (n = 84), living in the same geographical area. Using three different DNA polymorphisms of the gene encoding porphobilinogen deaminase (PBGD), a candidate gene for schizophrenia, an association with schizophrenia could not be detected. No significant associations were detected even after sub-division of the cohort by ethnicity and by gender.
Department of Psychiatry, University of Pittsburgh, School of Medicine, PA 15261.
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Nimgaonkar
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Ganguli
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SS
Washington
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A
Chakravarti
D000328:Adult; D000483:Alleles; D002874:Chromosome Mapping; D015331:Cohort Studies; D004247:DNA / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D011163:Hydroxymethylbilane Synthase / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*; D012565:Schizophrenic Psychology
D004247:DNA; D011163:Hydroxymethylbilane Synthase