[Selective analyzers of dopamine D2 receptors modulate serotonin metabolism in the striatum and nucleus accumbens of the rat brain during blockade of dopaminergic impulse flow].
Effects of D2 dopamine receptor selective agonists: quinpirole (0.1, 0.3 and 1 mg/kg, i. p.), pergolide (0.3 mg/kg, i. p.), lisuride (0.1 mg/kg, i. p.) and antagonist raclopride (1.2 mg/kg, i. p.) on the metabolism and synthesis of DA and serotonin in the rat brain striatum and nucleus accumbens after GBL treatment were studied. GBL as well as dopamine D2 receptor selective drugs were shown not only to change neurochemical parameters of dopaminergic brain systems, but also to modulate serotonin metabolism without affecting its biosynthesis.
Gaĭnetdinov
R R
RR
Bogdanov
M B
MB
Kudrin
V S
VS
Raevskiĭ
K S
KS
D015107:4-Butyrolactone / Q000494:pharmacology*; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism*; D015259:Dopamine Agents / Q000494:pharmacology*; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D004873:Ergolines / Q000494:pharmacology; D008090:Lisuride / Q000494:pharmacology; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects* / Q000378:metabolism*; D010479:Pergolide / Q000494:pharmacology; D019257:Quinpirole; D020891:Raclopride; D051381:Rats; D017208:Rats, Wistar; D017448:Receptors, Dopamine D2 / Q000187:drug effects*; D012457:Salicylamides / Q000494:pharmacology; D012701:Serotonin / Q000378:metabolism*
D015259:Dopamine Agents; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D004873:Ergolines; D017448:Receptors, Dopamine D2; D012457:Salicylamides; D019257:Quinpirole; D010479:Pergolide; D012701:Serotonin; D020891:Raclopride; D008090:Lisuride; D015107:4-Butyrolactone
Selektivnye analizatory D2-dofaminovykh receptorov moduliruiut metabolizm serotonina v striatume i prilezhashchem iadre mozga krys pri blokade dofaminergicheskoĭ impul'satsii.