Fertility after simulated Fowler-Stephens orchiopexy in rats.
In order to determine the effects of the Fowler-Stephens orchiopexy (FSO) on fertility, young rats underwent simulated FSO, FSO and concurrent contralateral orchiectomy (FSO/OR), unilateral orchiectomy (OR), or sham operation (controls). Twelve weeks after the operation, each male rat was mated to two proven-fertile female rats for 17 days (three ovulatory cycles). Two weeks later, both male and female rats were killed. No pregnancy resulted from the matings of the FSO/OR males. In contrast, pregnancy ensued in 13 of 16 (81%) females in the FSO group, 9 of 14 (64%) in the OR group, and 11 of 12 (92%) in the control group. There were no fertile males in the FSO/OR group. In the FSO group, eight of eight males induced pregnancy in at least one female; in the OR group, six of seven (86%) males were fertile as were all six males in the control group. No differences in litter size or fetal weight were observed between fertile females in various groups.
Department of Surgery, UCLA School of Medicine.
R E
RE
Kelly
J D
JD
Phillips
E W
EW
Fonkalsrud
H
H
Dindar
D000818:Animals; D001158:Arteries; D003456:Cryptorchidism / Q000601:surgery; D005260:Female; D005298:Fertility; D008026:Ligation; D008297:Male; D008722:Methods; D009919:Orchiectomy; D009929:Organ Size; D011183:Postoperative Complications; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000098:blood supply / Q000473:pathology / Q000601:surgery*; D014680:Veins