[Axonal neuropathy and salazosulfapyridine: slow-acetylator phenotype].
We report a case of an axonal sensorimotor neuropathy involving salazosulphapyridine in a slow-acetylator patient with ulcerative colitis. Rather than hypersensitivity the mechanism of the neuropathy can be assumed to be toxicity. The role played by the respective different metabolites in the occurrence of this uncommon side effect is uncertain.
Clinique des maladies du système nerveux et de l'appareil locomoteur, CHU Timone, Marseille.
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O
Blin
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Sangla
J
J
Jouglard
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C
Cottin
J F
JF
Pellissier
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G
Serratrice
D000107:Acetylation; D003093:Colitis, Ulcerative / Q000188:drug therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D010641:Phenotype; D012460:Sulfasalazine / Q000009:adverse effects* / Q000627:therapeutic use
D012460:Sulfasalazine
Neuropathie axonale et salazosulphapyridine: phénotype acétyleur lent.