Effect of morphine on phagocytic activity of the polymorphonuclears and monocytes.
The effect of morphine on the phagocytic activity of the polymorphonuclears (PMN), and monocytes in peripheral blood of laboratory rats of inbred Wistar strain was studied in vitro. Phagocytic activity of both types of the white blood cells was examined by the classical method using microspherical hydrophilic particles (Hema-particles), phagocytosis of the Hema-particles was determined by light microscopy. For evaluation of the leukocyte adherence, the method of MacGregor was used. Morphine was proved to influence phagocytic activity of individual types of the leukocytes in different way. Phagocytic activity of the PMNs was suppressed (by 14.0%), and that of monocytes was potentiated (by 17.1%).
Luza
J
J
Department of Physiology, Palacký University, Olomouc, Czechoslovakia.
D000818:Animals; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009000:Monocytes / Q000187:drug effects / Q000502:physiology*; D009020:Morphine / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D010587:Phagocytosis / Q000187:drug effects*; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar
D009020:Morphine