Antidiabetic sulfonylureas antagonize somatostatin inhibition of prolactin secretion in vitro.
Somatostatin-induced inhibition of prolactin secretion from adenohypophysis cells in culture is antagonized by the sulfonylurea glipizide, a specific blocker of ATP-sensitive K+ channels. The affinity constant for glipizide is K0.5 = 10 +/- 5 nM.
Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France.
M
M
Fosset
J
J
Epelbaum
M
M
Lazdunski
D000818:Animals; D002478:Cells, Cultured; D005260:Female; D005913:Glipizide / Q000494:pharmacology*; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D013004:Somatostatin / Q000037:antagonists & inhibitors*
D013004:Somatostatin; D011388:Prolactin; D005913:Glipizide