[Neuromediator provision of the organs of immune system in benzpyrene intoxication].
The density of adrenergic innervation and relative content of catecholamines were investigated in rat lymphoid organs under different type of benzpyrene treatment. It was found that both ante- and postnatal influence of toxicant leads to a decrease of neurotransmitter providing of the thymus, spleen, mesenterial, iliac and popliteal lymph nodes. On the contrary, when mixed ante- and postnatal benzpyrene influence has place, the adrenergic innervation density and relative content of catecholamines are increased. We suppose that benzpyrene treatment of pregnant animals has specific "training" effect for monoaminergic systems of foetus and causes the increase of neurotransmitter providing of immunocompetent organs in conditions of repeat body and toxicant meeting.
Borodin
Iu I
IuI
Izranov
V A
VA
Sklianova
N A
NA
Semeniuk
A V
AV
D000818:Animals; D001580:Benzopyrenes / Q000633:toxicity*; D002395:Catecholamines / Q000032:analysis; D005260:Female; D005333:Fetus / Q000187:drug effects*; D008198:Lymph Nodes / Q000737:chemistry / Q000187:drug effects* / Q000276:immunology; D018377:Neurotransmitter Agents / Q000032:analysis*; D011247:Pregnancy; D051381:Rats; D011941:Receptors, Adrenergic / Q000032:analysis; D013154:Spleen / Q000737:chemistry / Q000187:drug effects* / Q000276:immunology; D013950:Thymus Gland / Q000737:chemistry / Q000187:drug effects* / Q000276:immunology
D001580:Benzopyrenes; D002395:Catecholamines; D018377:Neurotransmitter Agents; D011941:Receptors, Adrenergic
Neĭromediatornoe obespechenie organov immunoĭ sistemy v usloviiakh intoksikatsii benzpirenom.