Platelet monoamine oxidase in schizophrenia: a meta-analysis.
We did a meta-analysis on all publications (English and other languages) concerned with platelet monoamine oxidase (MAO) in schizophrenia. Essentially, when patients were medicated with a neuroleptic, most studies found that schizophrenics had lower platelet MAO levels than controls. Administration of neuroleptic lowers MAO levels. MAO levels in drug-free schizophrenics were similar to controls. Only a minority of studies found drug-free schizophrenics had decreased platelet MAO levels.
Marcolin
M A
MA
Departamento de Psiquiatria, Faculdade de Medicina, Universidade de São Paulo, Brazil.
Davis
J M
JM
D014150:Antipsychotic Agents / Q000627:therapeutic use; D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology*; D006801:Humans; D008995:Monoamine Oxidase / Q000097:blood*; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy / Q000201:enzymology*; D012565:Schizophrenic Psychology
D014150:Antipsychotic Agents; D008995:Monoamine Oxidase