Extending the chemistry of enzymes and abzymes.
Selective chemical modification can be used to create novel proteins, particularly enzymes and antibodies, with altered specificities and catalytic activities in vitro. Modification strategies now being developed should soon yield a wide spectrum of novel biomolecules whose activities are optimized for specific industrial processes or therapeutic applications.
Department of Chemistry, Research Institute of Scripps Clinic, La Jolla, CA 92037.
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D000906:Antibodies / Q000737:chemistry; D002384:Catalysis; D003851:Deoxyribonucleases / Q000737:chemistry; D004798:Enzymes / Q000737:chemistry*; D008025:Ligases / Q000737:chemistry; D016297:Mutagenesis, Site-Directed; D010084:Oxidation-Reduction; D015202:Protein Engineering; D011993:Recombinant Fusion Proteins; D012260:Ribonucleases / Q000737:chemistry
D000906:Antibodies; D004798:Enzymes; D011993:Recombinant Fusion Proteins; D003851:Deoxyribonucleases; D012260:Ribonucleases; D008025:Ligases