[Influence of succinate on the effectiveness of glutamatergic synaptic transmission in surviving slices of rat hippocampus].
Sodium succinate has been studied for its influence on the efficiency of glutamate transmission in the Schaffer collateral synapses and duration of its potentiation state caused by high-frequency stimulation in surviving hippocampal slices. It is shown that administration of sodium succinate (50 mg/kg i. p.) to rats 30 min prior to decapitation stabilizes glutamate transmission in field CA1 of the rat hippocampal slices and increases duration of its potentiation state.
V I
VI
Malakhova
O V
OV
Godukhin
M N
MN
Kondrashova
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D005971:Glutamates / Q000502:physiology*; D018698:Glutamic Acid; D006624:Hippocampus / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D009474:Neurons / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013386:Succinates / Q000494:pharmacology*; D019802:Succinic Acid; D013569:Synapses / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
D005971:Glutamates; D013386:Succinates; D018698:Glutamic Acid; D019802:Succinic Acid
Vliianie suktsinata na éffektivnost' glutamatergicheskoĭ sinapticheskoĭ peredachi v perezhivaiushchikh srezakh gippokampa krys.