Influence of different occupations with possible mutagenic effects on reproduction and level of induced chromosomal aberrations in peripheral blood.
In a group of 200 dysfertile couples (400 persons), the possible role of different occupations in failures of reproduction was assessed. These couples were examined from different points of view, classical genetic examination (pedigree, kayrotype, etc.) included. The suspected genotoxic effects in the personal history were checked also by testing the level of induced chromosomal aberrations. A significantly increased level of induced chromosomal aberrations was detected in 37 persons, i.e., 9.3% of the whole group under study. The average level of induced aberration in these subjects was 6.8%, as opposed to the control group (fertile and dysfertile persons without any unusual exposure to mutagens) with a mean of 1.58% aberrant cells in peripheral blood. Most of the occupations with demonstrated genotoxic effects involve daily contact with chemicals of different types. In some persons also intensive therapy in the recent past had genotoxic effects.
Department of Genetics, Postgraduate Medical Institute, Prague, Czech and Slovac Federative Republic.
M
M
Kucerová
V
V
Gregor
J
J
Horácek
M
M
Dolanská
S
S
Matĕjcková
D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007246:Infertility / Q000097:blood / Q000209:etiology*; D008297:Male; D009153:Mutagens / Q000009:adverse effects*; D016273:Occupational Exposure; D012098:Reproduction / Q000187:drug effects
D009153:Mutagens