HIV-associated oral lesions; immunologic, virologic and salivary parameters.
There are numerous reports of oral lesions in HIV-infected individuals. However, few correlate the oral lesions with laboratory parameters. This study examined oral candidiasis and hairy leukoplakia, the two most common HIV-associated oral lesions, in relation to T-cell counts, p24 core antigen levels and salivary flow rates. Oral mucosal examinations, immunologic and virologic studies and stimulated whole and parotid saliva flow rates were conducted on 135 (HIV+ = 102, HIV- = 33) homosexual or bisexual men. Results indicate that, among HIV-infected subjects, the odds of having oral candidiasis is 6 times (95% CI = 0.6-56.6) greater for subjects with T4 counts between 200-399 per mm3, and 23 times (95% CI = 2.8-193.0) greater for subjects with T4 counts less than 200/mm3 compared to subjects with T4 counts of 400/mm3 or greater. Subjects had an equal likelihood of having hairy leukoplakia at different levels of immunocompetence. The prevalence of oral candidiasis and hairy leukoplakia was higher among subjects with infectious virus in their serum, but was only statistically significant for hairy leukoplakia (p = 0.01).
Barr
C E
CE
Department of Dental Medicine, Beth Israel Medical Center, New York, N.Y. 1003.
Lopez
M R
MR
Rua-Dobles
A
A
Miller
L K
LK
Mathur-Wagh
U
U
Turgeon
L R
LR
D000328:Adult; D016516:CD4-CD8 Ratio; D015496:CD4-Positive T-Lymphocytes; D002180:Candidiasis, Oral / Q000150:complications* / Q000276:immunology / Q000382:microbiology; D016009:Chi-Square Distribution; D015331:Cohort Studies; D006678:HIV / Q000302:isolation & purification; D016655:HIV Core Protein p24 / Q000097:blood; D015658:HIV Infections / Q000097:blood / Q000150:complications*; D006801:Humans; D016867:Immunocompromised Host; D007972:Leukoplakia, Oral / Q000150:complications* / Q000276:immunology / Q000382:microbiology; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012463:Saliva / Q000378:metabolism; D012636:Secretory Rate
D016655:HIV Core Protein p24