Model genomes: the benefits of analysing homologous human and mouse sequences.
The human genome initiative has provided the motivating force for launching sequencing projects suitable for testing various DNA-sequencing strategies, as well as motivating the development of mapping and sequencing technologies. In addition to projects targeting selected regions of the human genome, other projects are based on model organisms such as yeast, nematode and mouse. The sequencing of homologous regions of human and mouse genomes is a new approach to genome analysis, and is providing insights into gene evolution, function and regulation which could not be determined so easily from the analysis of just one species.
NSF Science and Technology Center for Molecular Biotechnology, California Institute of Technology, Pasadena 91125.
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Goverman
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Hunkapiller
D000818:Animals; D015894:Genome, Human; D006801:Humans; D051379:Mice / Q000235:genetics*; D008957:Models, Genetic; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid
D011948:Receptors, Antigen, T-Cell