Expression of interleukin-6 receptor on blood lymphocytes without in vitro activation.
A monoclonal antibody against the interleukin-6 receptor (IL-6R) has been used in a high-sensitivity immunofluorescence technique to study receptor expression on unstimulated blood lymphocytes. Most CD4 cells express IL-6 receptor, whilst a small and variable proportion of CD8 and B cells are positive. CD4+ cells express higher levels of receptor than CD8+ T cells, and CD45RO+ cells express higher levels than CD45RA cells.
Department of Clinical Immunology, Flinders Medical Centre, South Australia.
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D001402:B-Lymphocytes / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D011971:Receptors, Immunologic / Q000032:analysis*; D019947:Receptors, Interleukin-6; D013601:T-Lymphocytes / Q000276:immunology
D011971:Receptors, Immunologic; D019947:Receptors, Interleukin-6