Cerebrospinal fluid beta-2-microglobulin in multiple sclerosis and AIDS dementia complex.
Cerebrospinal fluid (CSF) and serum concentrations of beta-2-microglobulin (beta-2-m) were evaluated in 19 patients with clinically definite multiple sclerosis (MS), in 21 with AIDS dementia complex (ADC), and in 20 subjects with other neurological diseases (OND). CSF beta-2-m and CSF/serum beta-2-m ratio were significantly higher in the patients with ADC than in the MS and OND patients. The CSF and serum levels of beta-2-m in MS patients were not significantly different from those of OND patients. These findings indicate that CSF beta-2-m and CSF/serum ratio may be a useful marker in the diagnosis of ADC. In MS patients the beta-2-m CSF determinations are of no value.
Institute of Neurology, 2nd Medical School, University of Naples, Italy.
P B
PB
Carrieri
A
A
Indaco
A
A
Maiorino
G A
GA
Buscaino
A
A
Ponticiello
A
A
Liberti
O
O
Perrella
D015526:AIDS Dementia Complex / Q000134:cerebrospinal fluid*; D000328:Adult; D005260:Female; D006679:HIV Seropositivity; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid*; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid; D001613:beta 2-Microglobulin / Q000134:cerebrospinal fluid*
D001613:beta 2-Microglobulin