Antagonism of medetomidine sedation by atipamezole in pigs.
The efficacy of atipamezole as a medetomidine antagonist was evaluated in pigs. The atipamezole doses (intramuscularly) were 80, 160, 320 and 480 micrograms/kg of body weight, which were one, two, four and six times higher than the preceding medetomidine dose (80 micrograms/kg, intramuscularly). Atipamezole effectively reversed medetomidine-induced sedation, and the optimal action was seen at doses of 160 and 320 micrograms/kg. Recovery from sedation was quick and smooth, and adverse effects such as hyperactivity or tachycardia were minimal with either dose.
Department of Veterinary Surgery, Faculty of Agriculture, University of Tokyo, Japan.
R
R
Nishimura
H
H
Kim
S
S
Matsunaga
M
M
Sakaguchi
N
N
Sasaki
H
H
Tamura
A
A
Takeuchi
D000316:Adrenergic alpha-Agonists / Q000037:antagonists & inhibitors*; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006993:Hypnotics and Sedatives / Q000037:antagonists & inhibitors*; D007093:Imidazoles / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D008297:Male; D020926:Medetomidine; D013552:Swine / Q000502:physiology
D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D006993:Hypnotics and Sedatives; D007093:Imidazoles; C050701:atipamezole; D020926:Medetomidine