A novel NcoI polymorphism creates a fifth haplotype in the 3' untranslated region of CKM.
A novel NcoI polymorphism has been detected in the 3' untranslated region of the creatinine kinase (CKM) gene. The addition NcoI restriction site creates a fifth haplotype for the NcoI and TaqI restriction fragments length polymorphisms at this locus, and segregates with the myotonic dystrophy gene in 3 generations of an affected family.
Division of Medical and Molecular Genetics, United Medical School, Guy's Hospital, London, UK.
A M
AM
Differ
M
M
Bobrow
C G
CG
Mathew
D003402:Creatine Kinase / Q000235:genetics*; D015252:Deoxyribonucleases, Type II Site-Specific; D005260:Female; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D009223:Myotonic Dystrophy / Q000235:genetics*; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D014176:Protein Biosynthesis
D003402:Creatine Kinase; C052380:endodeoxyribonuclease NcoI; D015252:Deoxyribonucleases, Type II Site-Specific