Lipocortin and vasocortin: two species of anti-inflammatory proteins mimicking the effects of glucocorticoids.
The anti-inflammatory effect of glucocorticoids depends, at least in part, on the induction of two regulatory proteins, lipocortin and vasocortin, both preventing the release of inflammatory mediators. Lipocortin inhibits phospholipase A2 (PLA2) and therefore reduces arachidonic acid metabolites formation. Vasocortin inhibits histamine release from mast cells. Lipocortin and vasocortin may be regarded as the first two identified members of the (perhaps greater) family of glucocorticoid-induced proteins.
Department of Experimental Pharmacology, University of Naples, Italy.
L
L
Sautebin
R
R
Carnuccio
A
A
Ialenti
M
M
Di Rosa
D000818:Animals; D017302:Annexins; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D002135:Calcium-Binding Proteins / Q000494:pharmacology*; D006023:Glycoproteins / Q000494:pharmacology*; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects; D010741:Phospholipases A / Q000378:metabolism; D054467:Phospholipases A2; D011506:Proteins / Q000494:pharmacology*; D051381:Rats; D013256:Steroids
D017302:Annexins; D000893:Anti-Inflammatory Agents; D002135:Calcium-Binding Proteins; D006023:Glycoproteins; D011506:Proteins; D013256:Steroids; C052038:vasocortin; D010741:Phospholipases A; D054467:Phospholipases A2