A randomized trial of reduced doses of azidothymidine in Japanese patients with human immunodeficiency virus type 1 infection.
Adverse reactions to the standard dose (1,200 mg/day-1,500 mg/day) of azidothymidine (AZT) are serious. An in vitro pharmacokinetic study of intracellular AZT-5'-triphosphate suggested the feasibility of a clinical trial with reduced doses of AZT. A randomized trial with reduced doses of AZT (group A; 400 mg/day, n = 15, group B; 800 mg/day, n = 13), was conducted enrolling 28 patients with human immunodeficiency virus infection. The effective rate of AZT on CD4+ lymphocyte counts was similar for both groups, but the duration of the effect of AZT was significantly longer in group A (p less than 0.05). In group B, adverse reactions were more frequently observed (p less than 0.01), and AZT was withdrawn or the dose was reduced more frequently (p less than 0.05). These results suggest that AZT at a dose of 400 mg/day is less toxic, and is more beneficial for long-term treatment.
Kimura
S
S
Department of Infectious Diseases and Applied Immunology, University of Tokyo, Japan.
Oka
S
S
Toyoshima
T
T
Hirabayashi
Y
Y
Kikuchi
Y
Y
Mitamura
K
K
Shimada
K
K
D000293:Adolescent; D000328:Adult; D000855:Anorexia / Q000139:chemically induced; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects; D002493:Central Nervous System Diseases / Q000139:chemically induced; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology; D015497:HIV-1; D006801:Humans; D007564:Japan; D007958:Leukocyte Count / Q000187:drug effects; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D009325:Nausea / Q000139:chemically induced; D012307:Risk Factors; D015215:Zidovudine / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use
D015215:Zidovudine