Central-nervous-system dysfunction after warm or hypothermic cardiopulmonary bypass.
The increasing popularity of warm heart surgery led us to assess the effect of temperature during cardiopulmonary bypass (CPB) on neuropsychological function after coronary surgery. 34 patients enrolled in a randomised trial of normothermic versus hypothermic CPB were subjected to a battery of psychomotor and memory tests before and after their operations. The mean nasopharyngeal temperature for warm CPB was 34.7 (SD 0.5) degrees C and that for hypothermic CPB was 27.8 (2.0) degrees C. In all seven neuropsychological tests the postoperative scores were better in the warm CPB than in the hypothermic group, although only one difference achieved significance (trial-making test A; p less than 0.023). Thus, neurological function after normothermic CPB seems to be no worse than that after hypothermic procedures.
Department of Anaesthesia, Sunnybrook Health Centre, University of Toronto, Ontario, Canada.
B I
BI
Wong
R F
RF
McLean
C D
CD
Naylor
W G
WG
Snow
E M
EM
Harrington
M J
MJ
Gawel
R B
RB
Woods
S E
SE
Fremes
D001831:Body Temperature; D002315:Cardiopulmonary Bypass / Q000009:adverse effects* / Q000379:methods; D002493:Central Nervous System Diseases / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007036:Hypothermia, Induced; D008875:Middle Aged; D009483:Neuropsychological Tests; D010865:Pilot Projects; D011446:Prospective Studies