The spread of X-linked shifting gene responsible for G-6-PD deficit in series of 13,710 subjects from 4 districts of Moldavia.
Between 1985 and 1989, a sample of 13,710 subjects (5,825 males and 7,885 females) from the Vrancea, Bacău, Neamţ and Suceava districts were examined for the presence of this pathological gene, 32 male hemizygotes and 13 female heterozygotes and homozygotes being detected. The incidence of G-6-PD deficit in the hemizygotes was of 0.55%. The investigations carried out in the shifting gene carriers' families revealed the way deficit is transmitted to offsprings. Hemizygotes get it from their mother while the female homozygotes either from their mother or father. The frequency of G-6-PD deficit of 0.55% in a population sample of 13,710 subjects is within the limits established by Marcu and Schneer for our country (0.1-1.8%). By comparing the frequency of 0.55% in the Vrancea, Bacău, Neamţ and Suceava districts which formerly had an increased incidence of malaria (Galaţi - 4.01% and Huşi - 5.94%) its low value could be explained by the absence of malaria factor.
Institute of Hygiene and Medical Research, Iaşi, Romania.
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Ciofu
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Mironeanu
D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage / Q000235:genetics*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000453:epidemiology / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D015994:Incidence; D008297:Male; D008966:Moldova / Q000453:epidemiology; D014960:X Chromosome