Cerebrospinal fluid neurochemistry in children and adolescents with obsessive-compulsive disorder.
Cerebrospinal fluid hormones, monoaminergic metabolites, and dynorphin A (1-8 sequence) were examined in 43 children with severe, primary obsessive-compulsive disorder. Cerebrospinal fluid levels of 5-hydroxyindoleacetic acid were positively correlated with one of eight obsessive-compulsive disorder severity ratings and three of seven measures of improvement following 5 weeks of treatment with clomipramine hydrochloride. Arginine vasopressin concentration was significantly and negatively correlated with several ratings of obsessive-compulsive disorder symptom severity, while oxytocin concentration was positively correlated with depressive symptoms. The ratio of arginine vasopressin to oxytocin was also negatively correlated with obsessive-compulsive disorder and depressive symptoms. Comorbid affective disorder was associated with decreased arginine vasopressin concentrations, while concomitant anxiety disorder was associated with increased oxytocin. Dynorphin A (1-8 sequence), homovanillic acid, corticotropin, 3-methoxy-4-hydroxyphenylglycol, and corticotropin releasing hormone were not significantly related to obsessive-compulsive disorder symptoms. These results seem to indicate that arginine vasopressin may be related to obsessive-compulsive disorder symptom severity, while 5-hydroxyindoleacetic acid might be associated with drug response.
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Md 20892.
S E
SE
Swedo
H L
HL
Leonard
M J
MJ
Kruesi
D C
DC
Rettew
S J
SJ
Listwak
W
W
Berrettini
M
M
Stipetic
S
S
Hamburger
P W
PW
Gold
W Z
WZ
Potter
D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000134:cerebrospinal fluid; D000328:Adult; D001127:Arginine Vasopressin / Q000134:cerebrospinal fluid; D002648:Child; D002997:Clomipramine / Q000627:therapeutic use; D003346:Corticotropin-Releasing Hormone / Q000134:cerebrospinal fluid; D004399:Dynorphins / Q000134:cerebrospinal fluid; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000134:cerebrospinal fluid; D009479:Neuropeptides / Q000134:cerebrospinal fluid*; D009771:Obsessive-Compulsive Disorder / Q000134:cerebrospinal fluid* / Q000188:drug therapy / Q000523:psychology; D010121:Oxytocin / Q000134:cerebrospinal fluid; D010446:Peptide Fragments / Q000134:cerebrospinal fluid; D012720:Severity of Illness Index
D009479:Neuropeptides; D010446:Peptide Fragments; D001127:Arginine Vasopressin; D010121:Oxytocin; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D004399:Dynorphins; C026770:dynorphin (1-8); D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D002997:Clomipramine; D006719:Homovanillic Acid