Quantitative EEG and autonomic patterns of synthetic peptides related to dermorphin.
The effects of dermorphin on EEG and autonomic variables are compared with the effects of 2 analogues and 2 homologues, all administered intracerebroventricularly in the rabbit. Dermorphin was the most effective in modifying all considered parameters: increase of cortically derived and calculated total power, bradycardia, respiratory depression and hypothermia. The dibenzylated heptapeptide was essentially inactive. The electrocortical pattern induced by the administration of L-dermorphin suggests a functional correlation between the amino acid D-ala 2 and the effects on EEG. Comparison between the effects produced by the N-terminal tetrapeptide and pentapeptide led us to hypothesize that amino acid Tyr 5 may be specifically involved in inducing the autonomic effects.
Marchioni
E
E
Neurologic Institute C. Mondino, University of Pavia, Italy.
Maurelli
M
M
Tartara
A
A
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects*; D001833:Body Temperature Regulation / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects; D004569:Electroencephalography / Q000187:drug effects* / Q000295:instrumentation; D005071:Evoked Potentials / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D009842:Oligopeptides / Q000494:pharmacology*; D018847:Opioid Peptides; D010455:Peptides / Q000494:pharmacology*; D011817:Rabbits; D012119:Respiration / Q000187:drug effects; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*; D013329:Structure-Activity Relationship
D000701:Analgesics, Opioid; D009842:Oligopeptides; D018847:Opioid Peptides; D010455:Peptides; C030058:dermorphin