Combined cyclosporin-A and methylprednisolone treatment of Graves' ophthalmopathy.
Twelve patients with Graves' ophthalmopathy (grade 1-6, ATA classification) were treated with Cyclosporin-A, systemically in combination with methylprednisolone. We observed slight or moderate favourable effect in 9 cases. Our data suggest that the benefit was due to the methylprednisolone, the effectivity of which was enhanced by the cyclosporin even in the glucocorticoid-resistant cases.
First Department of Internal Medicine, University Medical School, Debrecen, Hungary.
A
A
Leövey
G
G
Bakó
J
J
Szabó
K
K
Kálmán
E
E
Fórizs
D000328:Adult; D016572:Cyclosporine / Q000008:administration & dosage* / Q000009:adverse effects; D004338:Drug Combinations; D005128:Eye Diseases / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006111:Graves Disease / Q000150:complications*; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D016896:Treatment Outcome; D014792:Visual Acuity / Q000187:drug effects
D004338:Drug Combinations; D016572:Cyclosporine; D008775:Methylprednisolone