Detection of serum IgM antibodies to glomerular basement membrane in two cases of nephropathia epidemica.
We report two serologically verified cases of nephropathia epidemica (NE) who developed high serum levels of non-Goodpasture IgM antibodies against glomerular basement membrane (anti GBM) in the acute phase of the disease. Moreover, in one of the patients a renal biopsy showed granular deposits of complement factor 3 along the glomerular capillary walls. The possible pathogenic significance of these findings is discussed.
Department of Infectious Diseases, University Hospital, Umeå, Sweden.
J
J
Billheden
B
B
Settergren
B
B
Stegmayr
P
P
Juto
D001323:Autoantibodies / Q000097:blood*; D001485:Basement Membrane / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006480:Hemorrhagic Fever with Renal Syndrome / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D007678:Kidney Glomerulus / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D001323:Autoantibodies; D007075:Immunoglobulin M