[The mechanism of the intranasal action of dermorphin in representatives of 2 classes of vertebrates].
It has been shown that endogenous opioid dermorphin induces effective analgesia after intranasal injection to fish (0.02-0.20 mg/kg) and rats (0.005 mg/kg). Maintenance of dermorphin analgesia after olfactory and trigeminal denervation indicates that the analgetic effect is not realized via the olfactory receptors or free terminals of the trigeminal nerve.
L S
LS
Chernova
A A
AA
Kamenskiĭ
G A
GA
Maliukina
E Iu
EIu
Baturina
V I
VI
Deĭgin
E P
EP
Iarova
D000281:Administration, Intranasal; D000701:Analgesics, Opioid / Q000008:administration & dosage; D000818:Animals; D005399:Fishes; D007274:Injections, Intraperitoneal; D009832:Olfactory Nerve / Q000502:physiology; D009842:Oligopeptides / Q000008:administration & dosage; D018847:Opioid Peptides; D010147:Pain Measurement; D051381:Rats; D013997:Time Factors; D014276:Trigeminal Nerve / Q000502:physiology; D014714:Vertebrates / Q000502:physiology*
D000701:Analgesics, Opioid; D009842:Oligopeptides; D018847:Opioid Peptides; C030058:dermorphin
Issledovanie mekhanizma intranazal'nogo deĭstviia dermorfina u predstaviteleĭ dvukh klassov pozvonochnykh.