Ontogenesis of pyroglutamyl peptidase II activity in rat brain, adenohypophysis and pancreas.
Pyroglutamyl peptidase II (PPII; E.C. 3.4.19.-) is a highly specific membrane-bound ectoenzyme degrading thyrotropin releasing hormone (TRH). The ontogenesis of this enzyme was measured in rat brain regions, adenohypophysis and pancreas. In hypothalamus PPII activity was maximal at day 8 postnatal, decreasing to adult values at day 45. The postnatal ontogenic patterns in posterior cerebral cortex and hypothalamus were similar. In olfactory bulb, two peaks of activity were observed (3th and 22nd day) while in adenohypophysis it appeared only at day 8, increased to day 30, decreasing thereafter to adult values.
Departamento de Bioquímica, Universidad Nacional Autónoma de México, Cuernavaca.
M A
MA
Vargas
J
J
Herrera
R M
RM
Uribe
J L
JL
Charli
P
P
Joseph-Bravo
D000818:Animals; D001921:Brain / Q000196:embryology / Q000201:enzymology* / Q000254:growth & development; D010179:Pancreas / Q000196:embryology / Q000201:enzymology* / Q000254:growth & development; D010903:Pituitary Gland, Anterior / Q000196:embryology / Q000201:enzymology* / Q000254:growth & development; D011751:Pyroglutamyl-Peptidase I / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D011751:Pyroglutamyl-Peptidase I