Sodium, calcium and exocytosis: confessions of calcified scientists.
Stimulated exocytotic secretion from nerve endings is initiated by an increase in intracellular free calcium concentration. We summarize here our latest findings regarding the temporal relationship between depolarization, elevation of [Ca2+]i and exocytosis in single vertebrate neuroendocrine nerve endings. In addition, we present surprising findings for a regulatory role of intracellular Na+ on exocytosis.
LNMIC Centre de Neurochimie, Strasbourg, France.
J
J
Nordmann
M
M
Lindau
E L
EL
Stuenkel
D000818:Animals; D002118:Calcium / Q000502:physiology*; D005089:Exocytosis / Q000502:physiology*; D006801:Humans; D009411:Nerve Endings / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism; D012964:Sodium / Q000502:physiology*
D018377:Neurotransmitter Agents; D012964:Sodium; D002118:Calcium