[Influence of radioactive contamination and iodine prophylaxis after the Czernobyl disaster on thyroid morphology and function of the Poznan region].
The radioactive contamination of Poznań Region was recognized after Chernobyl accident as average. The predicted values of minimal (inhalation) and maximal (inhalation and ingestion) committed dose equivalent to the thyroid varied from 2.5 (min) to 24.7 (max) mSv in different groups of adults and children. To follow up the results of iodine prophylaxis and some aspects of possible thyroid gland morphological and functional changes 11086 persons were carefully investigated clinically and biochemically. Among these 11086 persons were 42.6% males and 57.4% females both adults from 17 till 40 year and children up do 16 years. The following parameters were reviewed: pregnancy, time of residence in the region, thyroid abnormalities, family history concerning thyroid diseases, iodine intake in April and May 1986 with possible side effects, changes in the thyroid size observed before and after 1986, degree and kind of thyroid enlargement, serum concentration of T3, T4, TSH, ATMA and ATG titre and finally the effectiveness of thyroid blockade at 24, 48 and 72 h after ingestion of Lugol's solution. Side effects of the ingestion of potassium iodide from 30-70 mg were observed in 153 cases, 36 of them consulted medical doctors but in no case the side effects (dominated by vomiting) threatened the life. In the investigated group were 144 pregnant women. Majority, because 88% of them delivered the baby on or after time and 6.9% before time, 4.9% of natural abortions were noted but non artificial. In the group of children thyroid gland abnormalities before 1986 were reported in 3 cases in 23 after 1986 it is after Chernobyl accident. This information is interesting but needs more precise analysis of different dependencies occurring. The data obtained indicated the existence in Poznań. Region the goiter endemy because 27.5% of investigated children and adults had goiter classified as grades O-B, I, II and III. The elevation or diminution of T3 values were noted in 1164 cases, for T4 in 418 cases and for TSH in 1412 cases. The presence of antimembrane and antithyroglobulin antibodies were observed in 303 cases. All persons with changes observed in thyroid morphology and function are periodically controlled and the results will be published separately. The investigations performed and results presented concern the early aspects of radioactive contamination and effects of iodine prophylaxis. The answer regarding late effects including thyroid cancer needs further multi year studies for which the clinical material investigated in different parts of Poland and well documented should be used as model group for further periodical studies.
Klinika Endokrynologii Instytutu Chorób Wewnetrznych Akademii Medycznej w Poznaniu.
M
M
Gembicki
J
J
Sowiński
M
M
Ruchała
J
J
Bednarek
D000293:Adolescent; D000328:Adult; D000396:Air Pollutants, Radioactive / Q000009:adverse effects*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D011044:Poland; D011193:Potassium Iodide / Q000627:therapeutic use*; D011210:Power Plants; D011247:Pregnancy; D018788:Radioactive Hazard Release; D013959:Thyroid Diseases / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D013960:Thyroid Function Tests; D014455:Ukraine
D000396:Air Pollutants, Radioactive; D011193:Potassium Iodide
Wpływ skazenia radioaktywnego i profilaktyki jodowej w nastepstwie awarii reaktora atomowego w Czarnobylu na morfologie i czynność tarczycy mieszkańców regionu Poznańskiego.