Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent.
Medical Research Division, Lederle Laboratories, American Cyanamid Company, Pearl River, New York 10965.
J D
JD
Bloom
M D
MD
Dutia
B D
BD
Johnson
A
A
Wissner
M G
MG
Burns
E E
EE
Largis
J A
JA
Dolan
T H
TH
Claus
D000273:Adipose Tissue / Q000378:metabolism; D000318:Adrenergic beta-Agonists / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008066:Lipolysis / Q000187:drug effects; D008297:Male; D051379:Mice; D008820:Mice, Obese; D009765:Obesity / Q000188:drug therapy*; D013379:Substrate Specificity
D000318:Adrenergic beta-Agonists; D007004:Hypoglycemic Agents