Genetic engineering of beta-lactam antibiotic biosynthetic pathways in filamentous fungi.
Recombinant DNA technology has facilitated a rapid increase in our knowledge of beta-lactam antibiotic biosynthesis. Using the tools of this technology, beta-lactam biosynthetic genes and proteins have been characterized at the molecular level, cephalosporin-C production has been improved, new beta-lactams produced, and novel beta-lactam biosynthetic pathways have been constructed.
Skatrud
P L
PL
Lilly Research Labs., Lilly Corporate Center, Indianapolis, IN 46285.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry; D001709:Biotechnology; D003001:Cloning, Molecular; D005658:Fungi / Q000235:genetics / Q000378:metabolism; D005800:Genes, Fungal; D005818:Genetic Engineering; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D047090:beta-Lactams