Malignant change in trichilemmal cysts: a study of cell proliferation and DNA content.
We have examined proliferative activity in a series of pilar and trichilemmal cysts using an antibody to proliferating cell nuclear antigen. In benign lesions proliferative activity was confined to the basal layers of the squamous epithelium. Lesions showing malignant change showed increased proliferative activity and were not confined to the basal layer. These findings were correlated with studies on DNA content using flow cytometry.
Department of Histopathology, Mount Vernon Hospital, Northwood, Middlesex, UK.
G N
GN
Rutty
P I
PI
Richman
J H
JH
Laing
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D002455:Cell Division; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D004247:DNA / Q000032:analysis; D004814:Epidermal Cyst / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000032:analysis; D018809:Proliferating Cell Nuclear Antigen
D009687:Nuclear Proteins; D018809:Proliferating Cell Nuclear Antigen; D004247:DNA