Depression of the Ca(2+)-ATPase activity of the rat liver endoplasmic reticulum by the liver tumour promoters, 1,1,1-trichloro-2,2-bis(p-chlorophenyl)-ethane and phenobarbital.
The effects of a short-term in vivo administration of two liver tumour promoters (phenobarbital and 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane on rat liver endoplasmic reticulum Ca(2+)-ATPase were investigated. The specific activity values of this membrane-bound enzyme significantly decreased (P less than 0.01) by 51% for phenobarbital-treated rats and by 48% for 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane-treated rats compared with control animals. The depression of liver endoplasmic reticulum Ca(2+)-ATPase appears to be a manifestation of the toxicological effect of tumour promoters.
Department of Biochemistry, University of Ibadan, Nigeria.
G A
GA
Adenuga
E A
EA
Bababunmi
R G
RG
Hendrickse
D000818:Animals; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D002273:Carcinogens / Q000633:toxicity*; D003634:DDT / Q000633:toxicity*; D004721:Endoplasmic Reticulum / Q000187:drug effects* / Q000201:enzymology; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D010634:Phenobarbital / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D002273:Carcinogens; D003634:DDT; D005723:gamma-Glutamyltransferase; D000252:Calcium-Transporting ATPases; D010634:Phenobarbital