Effect of human thyroid stimulating autoantibodies on the radioiodine uptake of the mouse thyroid gland.
Administration of sera from patients with active Graves' disease to nude mice bearing human thyroid xenografts provides the opportunity to compare directly the effects of TSAb on thyroid tissue of different species. The results presented in this paper, namely the fact that only one of 8 Graves' sera increased the RAIU of the nu/nu mouse thyroids modestly while all sera increased the RAIU in the transplanted human tissue considerable, clearly show a species specific effect of TSAb.
Department of Internal Medicine, University of Berne, Inselspital, Switzerland.
H
H
Gerber
H J
HJ
Peter
H
H
Studer
D000818:Animals; D001323:Autoantibodies / Q000008:administration & dosage*; D006111:Graves Disease / Q000276:immunology; D006801:Humans; D007116:Immunization, Passive; D018828:Immunoglobulins, Thyroid-Stimulating; D007457:Iodine Radioisotopes / Q000378:metabolism*; D051379:Mice; D008813:Mice, Inbred ICR; D008819:Mice, Nude; D013961:Thyroid Gland / Q000378:metabolism* / Q000637:transplantation*; D013972:Thyrotropin / Q000494:pharmacology; D014183:Transplantation, Heterologous
D001323:Autoantibodies; D018828:Immunoglobulins, Thyroid-Stimulating; D007457:Iodine Radioisotopes; D013972:Thyrotropin