[Pharmacokinetics of broxaterol in asthmatic children].
Pharmacological profile of broxaterol, a new beta adrenergic compound, was investigated in 12 asthmatic children (6 male and 6 female with age 8-13 years). This study was performed from November to May, and venous blood was collected after 30, 45, 120, 180, 240 minutes from administration of 0.5 mg broxaterol; the urine was collected every 4 hours drug intake (0-4, 4-8, 8-12 hours). Drug absorption proved very fast: T max was 0.9 hours and Cmax was 2.05 micrograms/ml. T 1/2 was 2.3 hours. The urine concentration of broxaterol in the urine 0-4 and 4-8 hours after administration, was 6.11 and 2.3% (as drug percentage), after 8 hours no broxaterol was evaluated in the urine. Pharmacological profile of broxaterol in asthmatic children and adults is comparable.
Istituto Scientifico H S. Raffaele, Università degli Studi di Milano.
A
A
Flores D'Arcais
L
L
Crippa
D
D
De Biase
G
G
Romagnoni
D000293:Adolescent; D000318:Adrenergic beta-Agonists / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy / Q000378:metabolism*; D002648:Child; D005260:Female; D006801:Humans; D007555:Isoxazoles / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008297:Male
D000318:Adrenergic beta-Agonists; D007555:Isoxazoles; C045916:broxaterol
Farmacocinetica del broxaterolo in bambini affetti da asma.