(-)Deprenyl (selegiline) is devoid of amphetamine-like behavioural effects in rats.
Central effects of high dose (-)deprenyl (50-100 mg/kg sc) was compared to that of (+)deprenyl and (+/-)amphetamine (AM). (+)Deprenyl and AM induced stereotyped behaviour, increased spontaneous motility in smaller and decreased it in higher doses, inhibited escape behaviour and shuttle-box avoidance. (-)Deprenyl failed to possess any of these effects, providing further evidence that AM-type metabolites have no share in the action of (-)deprenyl.
Department of Pharmacology, Semmelweis University of Medicine, Budapest, Hungary.
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Tímár
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Knoll
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Knoll
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004924:Escape Reaction / Q000187:drug effects; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012642:Selegiline / Q000494:pharmacology*; D013239:Stereotyped Behavior / Q000187:drug effects
D000697:Central Nervous System Stimulants; D012642:Selegiline; D000661:Amphetamine