The effect of serum Ca2+ compensation on the efficacy of chlorpropamide in alloxan-diabetic rabbits.
A decrease in serum Ca2+ concentration was observed in alloxan-diabetic rabbits, with recovery of serum Ca2+ levels achieved following insulin therapy. This suggested that the diabetic condition directly relates to the decrease in serum Ca2+ levels. The efficacy of chlorpropamide in alloxan-diabetic rabbits after intravenous injection (150 mumol kg-1) was less than that in normal rabbits as measured by the serum insulin levels, and the efficacy did not change when the dose was increased. However, compensation of serum Ca2+ levels in alloxan-diabetic rabbits caused an increase in the efficacy of chlorpropamide observed as an increase in serum insulin and a decrease in serum glucose levels.
Department of Pharmaceutical Chemistry, University of Kansas, Lawrence 66045.
T
T
Nishihata
K
K
Sakai
A
A
Tsutsumi
M
M
Fukui
N
N
Yata
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002118:Calcium / Q000097:blood*; D002122:Calcium Chloride / Q000008:administration & dosage / Q000494:pharmacology; D002747:Chlorpropamide / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D007275:Injections, Intravenous; D007328:Insulin / Q000097:blood; D011817:Rabbits
D001786:Blood Glucose; D007328:Insulin; D002122:Calcium Chloride; D002118:Calcium; D002747:Chlorpropamide