Antiphospholipid antibodies after myocardial infarction and their relation to mortality, reinfarction, and non-haemorrhagic stroke.
Antiphospholipid antibodies have been suggested as markers for a high risk of recurrent cardiovascular events in young survivors of an acute myocardial infarction. However, there are few data to confirm or refute this hypothesis. In a cohort study, we have measured anticephalin (aCEPHA) and anticardiolipin (aCL) antibodies in a group of patients surviving an acute infarct. Of 597 patients studied, 13.2% were IgG or IgM aCEPHA positive compared with 4.4% of a reference population (n = 158; p = 0.002). In a multivariate analysis, adjusted for major cardiovascular risk factors, neither aCEPHA (IgG or IgM) nor a CL (IgG or IgM) was an independent risk factor for mortality, reinfarction, or non-haemorrhagic stroke. Although an increased proportion of survivors of a myocardial infarction have antiphospholipid antibodies, the presence of such antibodies is not a risk factor for subsequent coronary or cerebrovascular thrombosis.
Haematological Research Laboratory, Ullevål University Hospital, Oslo, Norway.
K E
KE
Sletnes
P
P
Smith
M
M
Abdelnoor
H
H
Arnesen
F
F
Wisløff
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000032:analysis / Q000276:immunology*; D015415:Biomarkers; D002308:Cardiolipins / Q000276:immunology; D002561:Cerebrovascular Disorders / Q000209:etiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D002542:Intracranial Embolism and Thrombosis / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000276:immunology* / Q000401:mortality; D010743:Phospholipids / Q000032:analysis / Q000276:immunology*; D011379:Prognosis; D012008:Recurrence; D012306:Risk; D012307:Risk Factors
D001323:Autoantibodies; D015415:Biomarkers; D002308:Cardiolipins; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010743:Phospholipids