Synthesis and biological activity of some new 2-chlorophenothiazine derivatives.
10-(Hetero/arylthio)acetyl-2-chlorophenothiazines II have been synthesized via interaction of 10-chloroacetyl-2-chlorophenothiazine I with heterocyclic and/or aromatic potassium mercaptide in ethanol. Oxidation of II using H2O2/CH3COOH mixture was studied. Structures of the products were verified by elemental and spectral analyses. Some compounds were screened in vitro for their antibacterial activities.
Department of Chemistry, Faculty of Science, Assiut University, Egypt.
S R
SR
el-Ezbawy
M A
MA
Alshaikh
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis; D001419:Bacteria / Q000187:drug effects; D001709:Biotechnology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010640:Phenothiazines / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D010640:Phenothiazines