Psychotic symptoms preceding ocular deviation in a patient with tardive oculogyric crises.
This report describes a patient with schizophrenia who developed episodes of ocular dystonia as a delayed side effect of neuroleptic medication. Each episode was preceded and accompanied by marked agitation, stereotypic behaviour and exacerbation of hallucinations. Both the psychotic and dystonic symptoms responded to anticholinergic medication. The theoretical and practical implications of this observation are discussed.
Sachdev
P
P
Neuropsychiatric Institute, Prince Henry Hospital, Little Bay, New South Wales.
Tang
W M
WM
D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001590:Benztropine / Q000008:administration & dosage; D002746:Chlorpromazine / Q000008:administration & dosage / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy / Q000209:etiology*; D005476:Fluphenazine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D006220:Haloperidol / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009460:Neurologic Examination / Q000187:drug effects; D015835:Ocular Motility Disorders / Q000139:chemically induced* / Q000188:drug therapy; D011605:Psychoses, Substance-Induced / Q000188:drug therapy / Q000209:etiology*; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology
D014150:Antipsychotic Agents; D001590:Benztropine; C011825:fluphenazine depot; D006220:Haloperidol; D005476:Fluphenazine; D002746:Chlorpromazine