Increased sexual behavior in male Macaca arctoides monkeys produced by atipamezole, a selective alpha 2-adrenoceptor antagonist.
The effect of a highly selective and potent alpha 2-adrenoceptor antagonist, atipamezole, on sexual behavior was studied in three stumptail macaques (Macaca arctoides). Following IM administration of atipamezole or saline control, the behavior of the male monkey with a female monkey was observed for 30 min. Atipamezole dose dependently (0.01-0.15 or 0.30 mg/kg) produced a significant increase in the number of ejaculations in all three monkeys, including an old one with decreased sexual activity in control conditions. Both ejaculations obtained by copulation and masturbation were increased. It is concluded that atipamezole is effective in increasing sexual behavior in male stumptail monkeys.
Department of Physiology, University of Helsinki, Finland.
I
I
Linnankoski
M
M
Grönroos
S
S
Carlson
A
A
Pertovaara
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D003307:Copulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D007093:Imidazoles / Q000494:pharmacology*; D008251:Macaca; D008297:Male; D008418:Masturbation; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013268:Stimulation, Chemical
D000317:Adrenergic alpha-Antagonists; D007093:Imidazoles; C050701:atipamezole