Acquired immunodeficiency without evidence of infection with human immunodeficiency virus types 1 and 2.
There have been three published cases of acquired immunodeficiency in which no evidence for infection with human immunodeficiency virus (HIV) types 1 and 2 was found. We have identified five other individuals, from the New York City area (four who have known risk factors for HIV infection), with profound CD4 depletion and clinical syndromes consistent with definitions of the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex. None had evidence of HIV-1, 2 infection, as judged by multiple serologies over several years, standard viral co-cultures for HIV p24 Gag antigen, and proviral DNA amplification by polymerase chain reaction.
Laurence
J
J
Laboratory for AIDS Virus Research, Cornell University Medical College, New York, NY 10021.
Siegal
F P
FP
Schattner
E
E
Gelman
I H
IH
Morse
S
S
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood*; D000328:Adult; D000368:Aged; D015704:CD4 Antigens / Q000302:isolation & purification; D005260:Female; D006679:HIV Seropositivity / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D015704:CD4 Antigens