Role of membrane components in thermal injury of cells and development of thermotolerance.
Exposure of cells to hyperthermia induces a transient resistance to subsequent heat treatment. The specific mechanisms responsible for hyperthermic cell killing and thermotolerance development are not well understood. It seems that heat may induce at least two different states of thermotolerance, of which one is dependent on protein synthesis. The expression of thermotolerance may include multiple cytoplasmic and membrane components. A number of studies have indicated that membranes play an important role in governing the thermal injury of cells. It seems, therefore, that heat denatured plasma membrane proteins may be a potential target for thermal stress and a trigger for the induction of thermotolerance. The localization of heat shock proteins in the plasma membrane and the suggestion of thermal resistance in enucleate erythrocytes support this suggestion. However, a direct relationship between the plasma membrane and hyperthermic killing or development of thermotolerance has not been found.
Jóźwiak
Z
Z
Chair of Biophysics, University of Lódź, Poland.
Leyko
W
W
D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D002118:Calcium / Q000502:physiology; D002468:Cell Physiological Phenomena; D006360:Heat-Shock Proteins / Q000502:physiology; D006358:Hot Temperature / Q000009:adverse effects*; D006801:Humans; D008563:Membrane Lipids / Q000502:physiology; D008565:Membrane Proteins / Q000502:physiology; D013438:Sulfhydryl Compounds / Q000502:physiology
D006360:Heat-Shock Proteins; D008563:Membrane Lipids; D008565:Membrane Proteins; D013438:Sulfhydryl Compounds; D002118:Calcium