[Significance of pathological alpha-1-fetoprotein levels in the framework of prenatal diagnosis].
Merkatz (1984) showed that in 68% of live birth with Down Syndrome maternal age was 34 years or less. It would be desirable to define a high risk collective of women younger then 35 years with the help of a screening test, which could further on lead to a prenatal diagnostics. Several studies showed that low maternal serum alpha-fetoprotein levels (SAFP) in pregnancy is associated with fetal chromosomal abnormalities. The results of a retrospective study at the Department of Obstetrics and Gynecology at University of Mainz showed that maternal SAFP-level does not accomplish the demand of a prenatal screening test, because only 17% of the Down Syndrome could be diagnosed by this parameter. In case of trisomy 13 and 18 SAFP-concentrations were normal or even increased, maybe on account of the combination with other malformations like neural-tube or abdominal-wall defects.
Universitäts-Frauenklinik.
F
F
Casper
V
V
Möbus
S
S
Wellek
D
D
Gehm
R
R
Seufert
P
P
Brockerhoff
R
R
Kreienberg
D000328:Adult; D000649:Amniocentesis; D002869:Chromosome Aberrations / Q000097:blood; D025063:Chromosome Disorders; D004314:Down Syndrome / Q000175:diagnosis*; D005260:Female; D006801:Humans; D011237:Predictive Value of Tests; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011296:Prenatal Diagnosis; D012016:Reference Values; D012189:Retrospective Studies; D014314:Trisomy; D000509:alpha-Fetoproteins / Q000032:analysis*
D000509:alpha-Fetoproteins
Der Stellenwert pathologischer Alpha-1-Fetoproteinkonzentrationen im Rahmen der pränatalen Diagnostik.