Endogenous scavenger levels (vitamin E and A) of patients with chronic alcoholic liver disease under different environmental conditions.
Serum level of endogenous scavengers (E and A vitamin) was studied in groups of patients with various chronic alcoholic liver diseases and in a healthy control group on polluted and non-polluted areas. Vitamin levels in patients with chronic liver disease are diminished in comparison to the healthy in general, but mainly in the cirrhotic group. Diminution of vitamin E levels was observed in earlier phase of liver disease than that of vitamin A levels. Patients and healthy control on polluted area showed more expressed diminution of vitamin levels than the same groups on non-polluted area. Free radical parameter (RBC diene conjugate content) and characteristic alcoholic parameters (serum GOT, gamma-GT, cholesterol level and liver GOT, gamma-GT content in biopsy specimen) were used to explain the differences between the same investigated groups on polluted and non-polluted areas. As conclusion can be supposed that industrial pollution of environment has a worsening effect in diseases with free radical mechanism.
1st Department of Medicine, Semmelweis University Medical School, Budapest, Hungary.
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Horváth
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Szabó
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Nagy
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Blázovics
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Gergely
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Schwarcz
D002784:Cholesterol / Q000097:blood; D002908:Chronic Disease; D004787:Environmental Pollution / Q000009:adverse effects*; D004910:Erythrocyte Membrane / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000473:pathology; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood / Q000201:enzymology / Q000473:pathology; D008108:Liver Diseases, Alcoholic / Q000097:blood* / Q000201:enzymology / Q000473:pathology; D008111:Liver Function Tests; D014801:Vitamin A / Q000097:blood*; D014810:Vitamin E / Q000097:blood*
D005609:Free Radicals; D014801:Vitamin A; D014810:Vitamin E; D002784:Cholesterol