Serum laminin in hepatosplenic human schistosomiasis.
Serum laminin level was measured in chronic hepatic schistosomiasis. A significant increase in the mean serum laminin levels was observed in patients with hepatosplenic (HS) schistosomiasis (2.57 +/- 0.83 U/ml), as compared to those in patients with the hepatointestinal (HI) form of the disease (1.38 +/- 0.45-U/ml) and in the control group (1.15 +/- 0.31 U/ml). In the HS patients there was a significant direct relation between serum laminin and percutaneous splenic pulp pressure (r = 0.68). These findings are compatible with an increased production of laminin in hepatosplenic schistosomiasis with may be related to the observed enlarged liver and spleen basement membranes in such disease.
Parise
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Disciplina de Gastroenterologia Clínica, Escola Paulista de Medicina, São Paulo, Brasil.
Leite-Mór
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Rosa
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D001485:Basement Membrane / Q000378:metabolism / Q000473:pathology; D002908:Chronic Disease; D005355:Fibrosis; D006801:Humans; D006975:Hypertension, Portal / Q000209:etiology; D007797:Laminin / Q000097:blood*; D008103:Liver Cirrhosis / Q000378:metabolism / Q000469:parasitology; D012552:Schistosomiasis / Q000097:blood* / Q000150:complications; D013154:Spleen / Q000378:metabolism / Q000473:pathology
D007797:Laminin