Major histocompatibility complex located complement C4 and steroid 21-hydroxylase gene rearrangements in couples with recurrent spontaneous abortions.
Major Histocompatibility Complex (MHC) class III located complement C4 and steroid 21-hydroxylase (21OH) genes, which form various deletion and duplication units, were studied by TaqI Restriction Fragment Length Polymorphism (RFLP) in 58 Finnish couples who suffered recurrent spontaneous abortions (RSA). The gene rearrangements found in the RSA couples did not differ from those in the controls.
Tissue Typing Laboratory, Finnish Red Cross Blood Transfusion Service, Helsinki.
T
T
Laitinen
M L
ML
Lokki
J
J
Partanen
M
M
Tulppala
O
O
Ylikorkala
S
S
Koskimies
D000026:Abortion, Habitual / Q000201:enzymology / Q000235:genetics* / Q000276:immunology; D003181:Complement C4 / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D015321:Gene Rearrangement; D006801:Humans; D008285:Major Histocompatibility Complex; D008297:Male; D005810:Multigene Family; D009154:Mutation; D012150:Polymorphism, Restriction Fragment Length; D011247:Pregnancy; D013255:Steroid 21-Hydroxylase / Q000235:genetics*
D003181:Complement C4; D013255:Steroid 21-Hydroxylase