Allele diversity of the H-ras-1 variable number of tandem repeats in Norwegian lung cancer patients.
We have examined restriction fragment length polymorphisms of the H-ras-1 gene in germ-line DNA from 214 lung cancer patients and 309 unaffected controls. When DNA samples were digested with MspI/HpaII, Southern blot analysis revealed at least 22 different alleles, grouped according to their frequencies as common, intermediate, and rare. The frequency of rare alleles in lung cancer patients (16/428) is significantly different (p = 0.002) from that in the control group (5/618). Individuals with rare alleles were found to be at 4.7-fold greater risk of lung cancer than those with no rare alleles.
Department of Toxicology, National Institute of Occupational Health, Oslo, Norway.
D
D
Ryberg
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T
Tefre
V
V
Skaug
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L
Stangeland
S
S
Ovrebø
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A
Naalsund
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AL
Børresen
A
A
Haugen
D000483:Alleles; D004273:DNA, Neoplasm / Q000235:genetics*; D011905:Genes, ras / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D009664:Norway; D012150:Polymorphism, Restriction Fragment Length; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics
D004273:DNA, Neoplasm