Iontophoretic permeation of sodium cromoglycate through synthetic membrane and excised hairless mouse skin.
The iontophoretic transport properties of sodium cromoglycate were characterized using a synthetic membrane and excised hairless mouse skin. The permeation rate of sodium cromoglycate through the synthetic membrane was found to be linearly dependent on the density of electrical current applied. Passive diffusion through the excised hairless mouse skin was not demonstrated for sodium cromoglycate; however, under iontophoresis, an appreciable permeation was exhibited by the drug through the animal skin, which was also found to be a function of the electrical current density.
College of Pharmacy, University of Oklahoma, Oklahoma City 73190.
L C
LC
Li
N T
NT
Vu
L V
LV
Allen
D000818:Animals; D004205:Cromolyn Sodium / Q000493:pharmacokinetics*; D004594:Electrophysiology; D005260:Female; D066298:In Vitro Techniques; D007478:Iontophoresis; D008567:Membranes, Artificial; D051379:Mice; D008812:Mice, Hairless; D010539:Permeability; D012044:Regression Analysis; D012869:Skin Absorption
D008567:Membranes, Artificial; D004205:Cromolyn Sodium