[Elevated serum levels of ICAM-1 in Wegener's granulomatosis].
Circulating soluble ICAM-1 (sICAM-1) isoforms are known to be elevated in inflammatory and autoimmune disorders (SLE, RA). A correlation between levels of circulating sICAM-1 and disease activity was described (5). In sera from 31 patients suffering from histologically confirmed Wegener's granulomatosis (WG) elevated levels of ICAM-1 were now detected in this primary systemic vasculitis. In generalized active disease circulating ICAM-1 levels were significantly higher when compared to remission and healthy control individuals. Sera from WG patients collected during intercurrent infections while on immunosuppressive drugs showed no elevation of circulating ICAM-1.
Abteilung für klinische Rheumatologie, Medizinischen Universität zu Lübeck.
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S
Hauschild
W H
WH
Schmitt
J
J
Kekow
C
C
Szymkowiak
W L
WL
Gross
D015703:Antigens, CD / Q000097:blood; D015815:Cell Adhesion Molecules / Q000097:blood* / Q000737:chemistry; D014890:Granulomatosis with Polyangiitis / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D018799:Intercellular Adhesion Molecule-1; D012995:Solubility
D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D007166:Immunosuppressive Agents; D018799:Intercellular Adhesion Molecule-1
Hohe Serumspiegel von ICAM-1 bei der aktiven generalisierten Wegenerschen Granulomatose.