Genetic evidence that placental site trophoblastic tumours can originate from a hydatidiform mole or a normal conceptus.
The genetic origin of two placental site trophoblastic tumours was established using a Y chromosome-specific and locus-specific minisatellite probes. A gestational origin was confirmed for both tumours. In one case the origin of the tumour was consistent with derivation from a normal female conceptus while the other was shown to arise from a homozygous complete hydatidiform mole, an abnormal conceptus more usually associated with the development of choriocarcinoma.
Cancer Research Campaign Laboratories, Charing Cross and Westminster Medical School, London, UK.
R A
RA
Fisher
F J
FJ
Paradinas
E S
ES
Newlands
G M
GM
Boxer
D000328:Adult; D015342:DNA Probes; D004276:DNA, Satellite / Q000032:analysis; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000150:complications* / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000209:etiology* / Q000235:genetics / Q000473:pathology
D015342:DNA Probes; D004276:DNA, Satellite