[Monomerization of the fragment D dimer of stabilized fibrin by a secretion from the medicinal leech salivary gland].
The salivary gland secretion of the medicinal leech catalyzes the conversion into monomeric form of the fragment D dimer, the product of limited proteolysis of stabilized fibrin. Analysis of N-terminal sequences revealed identical fragments for the D-dimer gamma-gamma-chains and the D-monomer gamma-chains formed via this reaction and established the presence of only one N-terminal amino acid (Ser). These results provide evidence for the preservation of integrity of the polypeptide chains during monomerization of the D-dimer.
L L
LL
Zavalova
E V
EV
Kuzina
N B
NB
Levina
I P
IP
Baskova
D000595:Amino Acid Sequence; D000818:Animals; D010450:Endopeptidases / Q000378:metabolism; D005338:Fibrin Fibrinogen Degradation Products / Q000737:chemistry / Q000378:metabolism*; D006868:Hydrolysis; D007865:Leeches; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry / Q000378:metabolism*; D011108:Polymers; D012469:Salivary Glands / Q000201:enzymology
D005338:Fibrin Fibrinogen Degradation Products; D010446:Peptide Fragments; D011108:Polymers; C036309:fibrin fragment D; D010450:Endopeptidases; C045348:fibrin destabilase
Monomerizatsiia dimera fragmenta D stabilizirovannogo fibrina sekretom sliunnykh zhelez meditsinskoĭ piiavki.