Hypertension in the elderly.
More than 50% of the U.S. population 65 years and older have elevated systolic pressure with or without elevated diastolic pressure--and thus in either case are at risk for cerebrovascular and cardiovascular sequelae. As therapy lowers diastolic pressure, however, mortality can increase, presumably when blood pressure is brought down to levels that compromise perfusion.
Weinberger
M H
MH
Indiana University School of Medicine, Indianapolis.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004232:Diuretics / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D008875:Middle Aged; D012982:Sodium, Dietary / Q000378:metabolism; D013599:Systole / Q000502:physiology
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D004232:Diuretics; D012982:Sodium, Dietary