A new depsipeptide antibiotic, variapeptin.
A culture similar to Streptomyces variabilis was found to produce a novel cyclic hexadepsipeptide antibiotic named variapeptin. Variapeptin is structurally related to azinothricin, A83586C, and citropeptin. The antibiotic was active against Gram-positive bacteria and showed cytotoxic activity against mammalian cells.
Pharmaceutical Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.
M
M
Nakagawa
Y
Y
Hayakawa
K
K
Adachi
H
H
Seto
D000595:Amino Acid Sequence; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D003470:Culture Media; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000254:growth & development* / Q000648:ultrastructure
D000903:Antibiotics, Antineoplastic; D003470:Culture Media; D010456:Peptides, Cyclic; C064643:variapeptin