[High level of tumor necrosis factor alpha activity of plasma and serum from acute phase hemorrhagic fever with renal syndrome].
The level of TNF-alpha activity of plasma and serum from HFRS acute phase patients was investigated. The level of TNF (tumor necrosis factor) activity of plasma and serum from acute phase patients was higher than that of plasma and serum from convalescent phase patients or from normal group. The higher TNF activity of plasma or serum from acute phase patients was due to TNF-alpha, because the TNF activity was almost completely inhibited by polyclonal mouse serum against rHuTNF-alpha. Also, the increase in TNF-alpha positive ratio of PBMC from acute phase HFRS patients was found as compared to convalescent phase patients or to normal group. All these results strongly suggest that high level of TNF-alpha activity of plasma and serum may be involved in the development of clinic symptoms and pathological lesions during the course of HFRS disease.
Department of Immunology, Fourth Military University Xi'an.
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C
Huang
D006480:Hemorrhagic Fever with Renal Syndrome / Q000097:blood*; D006801:Humans; D007150:Immunohistochemistry; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D014409:Tumor Necrosis Factor-alpha