Beta-adrenergic responsiveness of the gastrointestinal tract in diabetic rats.
Recently, decreased gastrointestinal beta-adrenergic responses in experimental diabetes have been demonstrated. Gastrointestinal responses to beta-adrenoceptor agonists are impaired in both insulin-dependent and non-insulin-dependent diabetic rat. Insulin treatment improves the impaired gastrointestinal beta-adrenergic responsiveness of diabetic rats. The improvement seen with insulin treatment on beta-adrenergic responsiveness is closely related to protein biosynthesis. The decreased beta-adrenergic responses in diabetic rat gastrointestinal tract seem to result from a decrease in the number of beta-adrenoceptors. It is most likely that the decreased gastrointestinal beta-adrenergic responsiveness is related to an impairment in the turnover of beta-adrenoceptors as a consequence of diabetes and that insulin has a beneficial effect on the impaired receptor turnover.
Oztürk
Y
Y
Department of Pharmacology, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.
Altan
V M
VM
Yildizoğlu-Ari
N
N
D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism*; D004064:Digestive System / Q000378:metabolism*; D006325:Heart Atria / Q000187:drug effects; D007328:Insulin / Q000627:therapeutic use; D009130:Muscle, Smooth / Q000187:drug effects; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D013311:Streptozocin
D000318:Adrenergic beta-Agonists; D007328:Insulin; D011943:Receptors, Adrenergic, beta; D013311:Streptozocin