The effect of glycine administration on taurine concentration in the rat liver.
1. The treatment of rats with glycine (2 mg/g) produced a marked decrease in the hepatic taurine content of neonate rats but not of adult rats. 2. The decrease observed in taurine concentration in the liver of newborn rats was not found in other organs, such as brain or kidney. 3. The results showed that the change in hepatic taurine concentration was dose- and time-dependent, suggesting the existence of an exchange mechanism between taurine and glycine in the rat liver that could participate in regulating the hepatic concentration of these amino acids.
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Murcia, Spain.
J D
JD
Galindo
A
A
Cremades
F
F
Monserrat
R
R
Peñafiel
D000375:Aging / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D005998:Glycine / Q000378:metabolism / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013654:Taurine / Q000378:metabolism*
D013654:Taurine; D005998:Glycine