CD4-targeted immune intervention: a strategy for the therapy of AIDS and autoimmune disease.
The cell-surface antigen CD4 plays a pivotal role in the class II MHC-restricted response of specific T lymphocytes, and serves as the major receptor of human immunodeficiency virus (HIV). The recent elucidation of CD4 function in physiological and pathological conditions has improved prospects for CD4-targeted immune therapy by facilitating the design of therapeutic strategies aimed at blocking CD4 function, delivering immunosuppressive signals via this receptor molecule, or selectively depleting CD4+ cells.
Auffray
C
C
Institut d'Embryologie du CNRS Collège de France, Nogent-sur-Marne.
Piatier-Tonneau
D
D
Kroemer
G
G
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000628:therapy*; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D015704:CD4 Antigens / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*
D015704:CD4 Antigens