[Contribution of single photon emission computerized tomography (SPECT-HMPAO) to the study of schizophrenia].
The authors studied a group of thirteen schizophrenic patients with functional brain imaging, using single-photon-emission-computed tomography (S.P.E.C.T.). The radiotracer was the H.M.P.A.O. labelled with 99 m Technetium. All were being given neuroleptic drug. Forty-one lesions demonstrated decreased perfusion. These functional abnormalities are mainly located in the left hemisphere and this asymmetry is more pronounced in positive-symptom schizophrenics. However, at rest, these correlations are limited and finally we demonstrated a wide spectrum of metabolic dysfunctions in the same subtype of schizophrenia.
Service de Pschiatrie B1, Hôpital Gaston-Doumergue, C.H.R.U., Nîmes.
T
T
Humbert
C
C
Maktouf
D
D
Surel
G
G
Grasset
P
P
Chabrand
D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000098:blood supply* / Q000000981:diagnostic imaging; D003702:Delusions / Q000145:classification / Q000000981:diagnostic imaging / Q000503:physiopathology; D004292:Dominance, Cerebral / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006212:Hallucinations / Q000145:classification / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010091:Oximes; D011569:Psychiatric Status Rating Scales; D011877:Radionuclide Imaging; D012039:Regional Blood Flow / Q000502:physiology; D012559:Schizophrenia / Q000145:classification / Q000000981:diagnostic imaging* / Q000503:physiopathology; D012565:Schizophrenic Psychology; D019690:Technetium Tc 99m Exametazime
D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime
Contribution a l'étude de la schizophrénie par la tomographie par émission de simples photons (S.P.E.C.T.-H.M.P.A.O.).