Biotransformation of 18 beta-glycyrrhetinic acid by cell suspension cultures of Glycyrrhiza glabra.
Two biotransformation products formed from 18 beta-glycyrrhetinic acid by cell suspension cultures of Glycyrrhiza glabra were isolated and their structures determined by chemical and spectral data as 3-O-[alhpa-L-arabinopyranosyl-(1----2)-beta-D-Glucuronopy ranosyl]-24- hydroxy-18 beta-glycyrrhetinic acid and 30-O-beta-D-glycopyrano-syl-18 beta-glycyrrhetinic acid. The formation of glycyrrhizin, the main triterpene glucuronide of the licorice root, was not detected among the biotransformation products. This is the first report of the glucuronylation of an exogenous triterpene in plant cell cultures.
Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
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Hayashi
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Fukui
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Tabata
D001711:Biotransformation; D002478:Cells, Cultured; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000378:metabolism*; D006035:Glycyrrhiza / Q000378:metabolism*; D019695:Glycyrrhizic Acid; D015394:Molecular Structure; D010946:Plants, Medicinal
D019695:Glycyrrhizic Acid; D006034:Glycyrrhetinic Acid