Clonal analysis of T-cell responses to the HIV-1 envelope proteins in AIDS vaccine recipients.
Both CD4+ and CD8+ CTL responses specific for the HIV-1 envelope proteins can be elicited in seronegative humans by candidate AIDS vaccines. The phenotype of the responding CTL depends upon the nature of the vaccine, with CD8+ CTL being found exclusively in recipients of live virus vaccines. Both types of CTL are active against HIV-1-infected cells in vitro. However, the potential efficacy of vaccine-induced CTL in preventing infection in vaccinated individuals exposed to HIV-1 is unknown and is likely to be dependent upon complex factors including lytic activity against divergent strains, cytokines produced, and the lysis of noninfected CD4+ T cells.
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
R F
RF
Siliciano
R C
RC
Bollinger
K M
KM
Callahan
S A
SA
Hammond
A Y
AY
Liu
E P
EP
Miskovsky
J F
JF
Rowell
P E
PE
Stanhope
D016915:AIDS Vaccines / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002999:Clone Cells / Q000276:immunology; D015686:Gene Products, env / Q000008:administration & dosage / Q000276:immunology*; D015488:HIV Antigens / Q000008:administration & dosage / Q000276:immunology*; D015699:HIV Envelope Protein gp120 / Q000276:immunology; D019302:HIV Envelope Protein gp160; D006679:HIV Seropositivity / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006681:HLA-D Antigens / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D011498:Protein Precursors / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000276:immunology; D014614:Vaccines, Synthetic / Q000276:immunology*
D016915:AIDS Vaccines; D015686:Gene Products, env; D015488:HIV Antigens; D015699:HIV Envelope Protein gp120; D019302:HIV Envelope Protein gp160; D006681:HLA-D Antigens; D011498:Protein Precursors; D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic