Impairment of some granulocyte functions in Sweet's syndrome.
Chemotaxis, phagocytic and intracellular killing activities of polymorphonuclear leukocytes (PMNL) were investigated in vitro in 7 patients suffering from the acute phase of Sweet's syndrome. A moderate but consistent impairment of neutrophilic chemotactic activity (NCA) was revealed in all patients. Intracellular killing of blastospores of Candida albicans was diminished in 5/7 patients. Phagocytosis and oxidase activities were within normal levels. These results point to an alteration of some PMNL functions in the acute phase of Sweet's syndrome.
von den Driesch
P
P
Department of Dermatology, University of Erlangen-Nürnberg, Germany.
Simon
M
M
Schlegel Gomez
R
R
Hornstein
O P
OP
D002176:Candida albicans; D002634:Chemotaxis, Leukocyte; D003602:Cytotoxicity, Immunologic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000502:physiology*; D010587:Phagocytosis; D016463:Sweet Syndrome / Q000276:immunology / Q000503:physiopathology*