Disposition of human drug preparations in the horse. II. Orally administered fencamfamine.
A gas chromatographic method to measure urinary levels of the central nervous system stimulant fencamfamine and some of its metabolites is described. When 100 mg fencamfamine was given orally to four horses the parent drug could not be detected in the urine. After enzymatic hydrolysis of the urine the major human metabolite, N-desethylated fencamfamine, only accounted for 1% of the dose in 12 h. The major equine metabolites were conjugated parahydroxylated compounds representing 18% of the dose. With regard to horse doping control and analysis, the injudicious use of human doping routine methods for the detection of fencamfamine in equine urine could lead to false negative results.
Labo voor Farmacologie en Toxicologie, Faculteit Diergeneeskunde, Universiteit Gent, Belgium.
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Debackere
D000284:Administration, Oral; D000818:Animals; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002849:Chromatography, Gas; D004300:Doping in Sports; D005260:Female; D006736:Horses; D006868:Hydrolysis; D006900:Hydroxylation; D007202:Indicators and Reagents; D009636:Norbornanes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D000697:Central Nervous System Stimulants; D007202:Indicators and Reagents; D009636:Norbornanes; C020900:fencamfamine