Identification of a novel 5-HTN (Nematoda) receptor from Ascaris suum muscle.
1. The abilities of various serotonergic drugs to bind with the 5-HT receptor of Ascaris suum muscle and to affect cyclic AMP levels in muscle tissue were examined. 2. Ligands which selectively interact with either the 5-HT1 or the 5-HT2 receptor in mammalian systems interact with the 5-HT receptor from A. suum muscle and increase cyclic AMP levels. 3. No binding of 5-HT3 ligands to 5-HT receptors from A. suum muscle was observed. 4. The 5-HT receptor of A. suum muscle should be called the 5-HTN (for Nematoda) receptor because its pharmacological and biochemical behaviors were different from those of mammalian 5-HT receptors.
Williams
J A
JA
Department of Biological Sciences, University of North Texas, Denton 76203.
Shahkolahi
A M
AM
Abbassi
M
M
Donahue
M J
MJ
D000818:Animals; D001200:Ascaris / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D011985:Receptors, Serotonin / Q000032:analysis* / Q000187:drug effects
D011985:Receptors, Serotonin; D000242:Cyclic AMP