Cerebrospinal fluid myelin basic protein as predictive marker of demyelination in AIDS dementia complex.
Myelin basic protein (MBP) was measured in cerebrospinal fluid (CSF) of patients with acquired immunodeficiency syndrome (AIDS) dementia complex (ADC) in order to investigate the degree of white matter destruction. Results show that increased CSF levels of MBP were detected in all patients with severe ADC (10/10) and, less often, in subjects with mild (2/7) or moderate dementia (7/16). No evidence of MBP-elevated concentration was observed in 14 human immunodeficiency virus (HIV)-seropositive subjects without neurological disorders and in nine HIV-seronegative controls. Our findings suggest that the measurement of CSF MBP concentration may represent a predictive marker of myelin injury and neurologic damage during the course of ADC.
Dipartimento di Biochimica e Biologia Molecolare, Università di Bari, Italy.
G M
GM
Liuzzi
C M
CM
Mastroianni
V
V
Vullo
E
E
Jirillo
S
S
Delia
P
P
Riccio
D015526:AIDS Dementia Complex / Q000134:cerebrospinal fluid*; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D003711:Demyelinating Diseases / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D004676:Myelin Basic Protein / Q000134:cerebrospinal fluid*
D015415:Biomarkers; D004676:Myelin Basic Protein