Cross reactivity among the ligands of the 7 helix family.
"Specific" drugs for receptors of the 7 helix family inhibited in high doses other receptors of the same family, as well. Atropine inhibited [3-H]-clonidine binding, beta-adrenergic drugs: propranolol, betoxalol, ICI 118.551 inhibited labelled QNB binding to all the 3 main subtypes of muscarinic receptors. Authors propose the existence of common features in the ligand binding sites of the receptors of 7 helix family.
Simon
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Semmelweis Medical University, Department of Oral Biology, Budapest, Hungary.
Pásztélyi
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Zelles
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D000319:Adrenergic beta-Antagonists / Q000493:pharmacokinetics; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001667:Binding, Competitive / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D003000:Clonidine / Q000493:pharmacokinetics; D003429:Cross Reactions; D004298:Dopamine / Q000494:pharmacology; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008024:Ligands; D008566:Membranes / Q000187:drug effects / Q000378:metabolism; D011813:Quinuclidinyl Benzilate / Q000493:pharmacokinetics; D051381:Rats; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D005971:Glutamates; D008024:Ligands; D011956:Receptors, Cell Surface; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D011813:Quinuclidinyl Benzilate; D001285:Atropine; D007545:Isoproterenol; D003000:Clonidine; D004298:Dopamine