Striatal protection induced by lesioning the substantia nigra of rats subjected to focal ischemia.
Unilateral 6-hydroxydopamine lesion of the substantia nigra reduced the volume of striatal necrosis and suppressed the increase in extracellular glutamate concentration in the striatum induced by middle cerebral artery occlusion in rats. These results indicate that the dopaminergic nigrostriatal pathway is highly involved in the vulnerability of the striatum to ischemia and suggest that glutamate-dopamine interactions may play a key role in the striatal ischemic insult.
Laboratoire de Pharmacologie, Faculté des Sciences Pharmaceutiques et Biologiques, Université René Descartes, Paris, France.
A
A
Buisson
J
J
Callebert
E
E
Mathieu
M
M
Plotkine
R G
RG
Boulu
D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism; D002545:Brain Ischemia / Q000378:metabolism / Q000473:pathology*; D002544:Cerebral Infarction / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism / Q000473:pathology*; D004298:Dopamine / Q000378:metabolism; D005110:Extracellular Space; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D008297:Male; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000187:drug effects / Q000473:pathology*
D005971:Glutamates; D001224:Aspartic Acid; D018698:Glutamic Acid; D016627:Oxidopamine; D004298:Dopamine