Absence of denervation supersensitivity to neurokinin A in the rat vas deferens.
1. Unilateral denervation of the rat vas deferens (RVD) was performed under anesthesia. The animals were allowed to recover 4 or 10 days and then concentration-effect (C-E) curves to noradrenaline (NA) and neurokinin A (NKA) were constructed in denervated and control RVD. 2. Tissues denervated 4 or 10 days produced NA responses shifted 20-fold to the left with maxima 130% of control. 3. NKA C-E curves in denervated RVD were not significantly different from control. 4. Phenylephrine exhibited a 6-fold increase in tissue sensitivity after denervation. 5. Chronic denervation of the vas deferens resulted in significant postsynaptic supersensitivity to alpha 1-adrenoceptor agonists but not to NKA.
Abraham
S T
ST
Department of Pharmacology, J. H. Quillen College of Medicine, East Tennessee State University, Johnson City 37614.
Rice
P J
PJ
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000818:Animals; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009121:Muscle Denervation; D009130:Muscle, Smooth / Q000187:drug effects*; D015288:Neurokinin A / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013566:Sympathomimetics / Q000494:pharmacology; D014649:Vas Deferens / Q000187:drug effects / Q000294:innervation*
D000316:Adrenergic alpha-Agonists; D013566:Sympathomimetics; D010656:Phenylephrine; D015288:Neurokinin A; D009638:Norepinephrine