[Serum adenosine deaminase in human immunodeficiency virus infection. Its relationship with CD4+ lymphocytes and beta 2-microglobulin].
BACKGROUND
The activity of the deaminase adenosine enzyme (ADA) has principally been related with the functionalism and replication of the T lymphocytes. Its serum behavior and possible clinical use in infection by the human immunodeficiency virus type 1 (HIV-1) was studied.


METHODS
A multicenter study in which the serum values of ADA were examined and compared with those of two reference markers (CD4+ lymphocytes and beta 2-microglobulin) in 35 presumably healthy donors used as controls, in 60 intravenous drug users (IVDU) seronegative for HIV-1, in 69 HIV-1 asymptomatic seropositive intravenous drug users (HIV-1+) and in 48 patients with AIDS.


RESULTS
The serum values of ADA were as follows: control group 10.9 +/- 4.2 U/I; IVDU group 17.6 +/- 7.4 U/I; asymptomatic HIV-1+ group 32.7 +/- 10.2 U/I, AIDS group 46.2 +/- 18.2 U/I. Differences between the different groups were statistically significant in themselves and in relation to the control group. A negative correlation was observed (r = 0.47, p < 0.01) with the number of CD4+ lymphocytes and a positive correlation was found with respect to beta 2-microglobulin (r = 0.76, p < 0.001). The values of serum ADA activity in patients with AIDS and tuberculosis (47.4 +/- 17.2 U/I) were not significantly higher (p < 0.05) to those of patients with AIDS without this second infection (45.9 +/- 19.3 U/I).


CONCLUSIONS
Serum deaminase adenosine may be a useful evolutive marker for human immunodeficiency virus type 1 given that its activity increases significantly in infected patients in agreement with the grade of immunodeficiency and its values correlate well with those of reference markers (CD4+ lymphocytes and beta 2-microglobulin).
Servicio de Análisis Clínicos, Hospital del Servicio Andaluz de Salud de La Línea, Cádiz.
M A
MA
Iñigo
M
M
Ruiz López de Tejada
M
M
Torres-Tortosa
A
A
Sánchez-Porto
I
I
Ugarte
E
E
García de Lomas
A
A
Morán Nestares
D000163:Acquired Immunodeficiency Syndrome / Q000201:enzymology; D000243:Adenosine Deaminase / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D015496:CD4-Positive T-Lymphocytes; D015658:HIV Infections / Q000097:blood / Q000201:enzymology* / Q000276:immunology; D006679:HIV Seropositivity / Q000201:enzymology; D015497:HIV-1; D006801:Humans; D007958:Leukocyte Count; D001613:beta 2-Microglobulin / Q000032:analysis
D015415:Biomarkers; D001613:beta 2-Microglobulin; D000243:Adenosine Deaminase
Adenosina desaminasa sérica en la infección por el virus de la inmunodeficiencia humana. Su relación con los linfocitos CD4+ y la beta 2-microglobulina.