[An evaluation of the genotoxicity activity of the microbial preparation bulmoscide].
The genotoxic activity of the microbial preparation bulmoscid "in vivo" for somatic cells of mammals is studied by micronucleus method in marrow of mice. The experiments are performed on inbred mice C57BL6 of both sexes at unrepeated oral introduction of the preparation in two doses: 2200 mg/kg-1 (2.64.10(10) cells kg-1), and 1100 mg/kg-1 (1.32.10(10) cells kg-1) presenting 80% and respectively 40% of the unrepeated maximum tolerable dose of "Bulmoscid" for mice (2750 mg/kg-1). The genotoxic index, frequency of micronuclear polychromatophilic erythrocytes (MPE) in marrow is determined in dynamics on the 24, 48 and 72 hour after the introduction of the preparation. The data of the performed cytogenetic analysis in marrow of C57BL6 mice of both sexes point out that the preparation "Bulmoscid" possesses no clastogenic activity for mammals. The data received are extrapolated also in direction of absence of genotoxic potential for germinative cells.
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E
Mirkova
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Zh
Khalkova
D000818:Animals; D001413:Bacillus thuringiensis; D001853:Bone Marrow / Q000187:drug effects / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects / Q000648:ultrastructure; D005260:Female; D005796:Genes / Q000187:drug effects*; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D015162:Micronucleus Tests; D009930:Organic Chemicals
D007306:Insecticides; D009930:Organic Chemicals; C084026:bulmoscide
Otsena na genotoksichnata aktivnost na mikrobniia preparat bulmostsid.