Vitamin A deficiency and glucocorticoid receptor activity in rat liver.
The influence of vitamin A on the binding properties of hepatic glucocorticoid receptors (GR) was studied in young rats 7 weeks after they had been given a diet with or without vitamin A. Scatchard analysis showed an increased capacity of cytosolic GRs to bind dexamethasone in vitamin A deficiency. In these rats, an increase in tyrosine aminotransferase also occurred, and this could be related to the increased formation of hormone-GR complexes. Measurement of protein kinase C activity showed an increase which might be related to the functional activity of GRs.
Laboratoire de Nutrition, ISTAB, Université de Bordeaux I, Talence, France.
I
I
Audouin
H
H
Garcin
I
I
Pailler-Rodde
P
P
Higueret
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D003600:Cytosol / Q000378:metabolism; D003907:Dexamethasone / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D011493:Protein Kinase C / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D014444:Tyrosine Transaminase / Q000378:metabolism; D014802:Vitamin A Deficiency / Q000201:enzymology / Q000378:metabolism*
D011965:Receptors, Glucocorticoid; D003907:Dexamethasone; D014444:Tyrosine Transaminase; D011493:Protein Kinase C; D000469:Alkaline Phosphatase