[Relapse of peptic ulcer after quick healing induced by proton pump inhibitors].
Peptic ulcers treated with a proton pump inhibitor heal more quickly than those treated with a histamine H2 receptor antagonist. Although satisfactory healing without relapse is desirable in the medical treatment of peptic ulcers, the relapse rate after treatment with proton pump inhibitors has not been sufficiently studied. Up to now, several reports have suggested that peptic ulcers treated with omeprazole recur less frequently than those treated with H2 antagonists. Our experimental studies on angiogenesis in granulation tissue of acetic acid-induced gastric ulcers, gastric mucosal collagen synthesis etc., show that H2 antagonists have an inhibitory effect on wound healing, but that proton pump inhibitors do not. It is suggested, therefore, that proton pump inhibitors may at least have no undesirable effect on the natural history of peptic ulcer.
Second Department of Internal Medicine, Nagoya University School of Medicine.
Y
Y
Tsukamoto
Y
Y
Niwa
T
T
Arisawa
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000818:Animals; D016099:Endoscopy, Gastrointestinal; D005753:Gastric Mucosa / Q000473:pathology / Q000502:physiology; D017506:H(+)-K(+)-Exchanging ATPase; D006635:Histamine H2 Antagonists / Q000009:adverse effects; D006801:Humans; D009389:Neovascularization, Pathologic; D009853:Omeprazole / Q000494:pharmacology / Q000627:therapeutic use*; D010437:Peptic Ulcer / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D012008:Recurrence; D012038:Regeneration / Q000187:drug effects; D014463:Ultrasonography
D006635:Histamine H2 Antagonists; D000251:Adenosine Triphosphatases; D017506:H(+)-K(+)-Exchanging ATPase; D009853:Omeprazole