Resolution of several racemic 3-hydroxy-1,4-benzodiazepin-2-ones by high-performance liquid chromatography on a chiral silica-bonded stationary phase.
The resolution of four racemic 3-hydroxy-1,4-benzodiazepin-2-ones, widely used in therapeutics, by means of a chiral stationary phase is described. The chiral selector used is (S)-N-(3,5-dinitrobenzoyl)phenylalanine. This chiral stationary phase showed both good enantioselectivity and efficiency for the compounds. Elution times were in all cases shorter than those previously reported for such compounds on different stationary phases. Racemic oxazepam was used to evaluate the loading capacity of the chiral stationary phase.
Laboratoire de Chimie Générale (CNRS URA 1103), Paris, France.
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Oliveros
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Minguillon
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Billaud
D014151:Anti-Anxiety Agents / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification*; D001569:Benzodiazepines; D002851:Chromatography, High Pressure Liquid; D008140:Lorazepam / Q000031:analogs & derivatives / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification; D010076:Oxazepam / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification; D012822:Silicon Dioxide / Q000737:chemistry; D013237:Stereoisomerism; D013693:Temazepam / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D010076:Oxazepam; D012822:Silicon Dioxide; D013693:Temazepam; C023842:lormetazepam; D008140:Lorazepam