c-fos expression as a model for studying the action of hexachlorocyclohexane isomers in the CNS.
The induction of protooncogene c-fos in the CNS after administration of several convulsants has been studied. The organochlorine insecticide gamma-hexachlorocyclohexane (gamma-HCH, lindane) has been shown to induce c-fos expression in different brain areas. Pentylenetetrazole and picrotoxin, a known gamma-aminobutyric acid-receptor antagonist, have also been considered. The administration of two nonconvulsant isomers of gamma-HCH, alpha-HCH, and delta-HCH, before the mentioned toxicants, affects the protooncogene expression in different ways. The differential pattern of expression displayed by c-fos after these treatments suggests the presence of diverse mechanisms of action for the compounds studied.
Departament de Farmacologia i Toxicologia, CID-CSIC, Barcelona, Spain.
M
M
Vendrell
J M
JM
Tusell
J
J
Serratosa
D000818:Animals; D015152:Blotting, Northern; D001921:Brain / Q000187:drug effects*; D001556:Hexachlorocyclohexane / Q000494:pharmacology*; D007150:Immunohistochemistry; D007536:Isomerism; D008297:Male; D009693:Nucleic Acid Hybridization; D010433:Pentylenetetrazole / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats
D001556:Hexachlorocyclohexane; D010433:Pentylenetetrazole; D010852:Picrotoxin; D016760:Proto-Oncogene Proteins c-fos