[Varicella-zoster virus infection after peripheral blood stem cell autografts in children with leukemia or non-Hodgkin's lymphoma].
Thirty-two patients with leukemia or non-Hodgkin's lymphoma (NHL) who underwent high-dose chemotherapy without total body irradiation (TBI) and peripheral blood stem cell autografts (PBSCT) were evaluated for the occurrence of clinically manifested varicella-zoster virus infection (VZV). In a minimum follow-up of 3 mo, there were 14 cases with VZV; 12 patients were treated with intravenous acyclovir and 2 patients received additional intravenous VZV hyperimmune immunoglobulin preparations. History of previous varicella-zoster at some time before PBSCT was the only significant risk factor for the development of VZV. Furthermore, a significant association between VZV and higher disease-free survival rate after PBSCT was proved. Development of minor and reversible VZV is rather common event after high-dose chemotherapy without TBI and PBSCT. VZV appears to be one of the factors which reflects basic physiologic mechanism preventing relapse of leukemias or NHL after PBSCT.
Okamoto
Y
Y
Department of Pediatrics, University of Tokushima.
Takaue
Y
Y
Saito
S
S
Hirao
A
A
Suzue
T
T
Shimizu
T
T
Abe
T
T
Sato
J
J
Watanabe
T
T
Kawano
Y
Y
D000293:Adolescent; D002644:Chickenpox / Q000635:transmission*; D002648:Child; D002675:Child, Preschool; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000601:surgery*; D008228:Lymphoma, Non-Hodgkin / Q000601:surgery*; D008297:Male; D011183:Postoperative Complications; D014182:Transplantation, Autologous