Elemental mercury vapour toxicity, treatment, and prognosis after acute, intensive exposure in chloralkali plant workers. Part II: Hyperchloraemia and genitourinary symptoms.
Exposure to elemental mercury vapour is known to influence renal function; however, severe renal disease has not been consistently identified. Eleven men were evaluated for renal disease after acute, massive mercury poisoning. Significant hyperchloraemia was identified in this group of patient and a reversible renal tubular defect was suggested by low normal serum bicarbonate, a normal serum anion gap and a positive urinary anion gap. The only other evidence of renal dysfunction was transient, mild proteinuria in one of the 11 patients. During this same time period, neuropsychological impairment was identified on a test of cognitive and visual-motor function, 'Trailmaking B', in seven of the 11 patients. Additionally, dysuria and ejaculatory pain occurred without evidence of urological disease. These complaints were more frequent in those patients with impairment on 'Trailmaking B' suggesting a neurological basis for these symptoms. The findings of this study support earlier observations that the brain rather than the kidney is the critical target organ after elemental mercury vapour exposure.
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-6602.
R E
RE
Bluhm
J A
JA
Breyer
R G
RG
Bobbitt
L W
LW
Welch
A J
AJ
Wood
R A
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Branch
D000328:Adult; D015913:Chelation Therapy; D002712:Chlorides / Q000097:blood*; D003252:Construction Materials / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008630:Mercury Poisoning / Q000188:drug therapy / Q000503:physiopathology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D009784:Occupational Diseases / Q000188:drug therapy / Q000503:physiopathology*; D010396:Penicillamine / Q000031:analogs & derivatives / Q000627:therapeutic use; D011379:Prognosis; D011507:Proteinuria / Q000139:chemically induced*; D004113:Succimer / Q000627:therapeutic use; D014566:Urogenital System / Q000187:drug effects
D002712:Chlorides; C010005:N-acetylpenicillamine; D004113:Succimer; D010396:Penicillamine