Postsynaptic contribution to long-term potentiation revealed by the analysis of miniature synaptic currents.
Miniature excitatory synaptic currents were recorded from CA1 pyramidal cells in hippocampal slices to study the site of the persistent change in synaptic efficacy during long-term potentiation. Induction of long-term potentiation produced a large increase in the amplitude of these currents. Such a change in amplitude suggests an increase in postsynaptic transmitter sensitivity.
Department of Pharmacology, University of California, San Francisco 94143-0450.
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Manabe
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Renner
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Nicoll
D018750:6-Cyano-7-nitroquinoxaline-2,3-dione; D000818:Animals; D004558:Electric Stimulation / Q000379:methods; D005071:Evoked Potentials / Q000187:drug effects; D006624:Hippocampus / Q000502:physiology*; D066298:In Vitro Techniques; D016202:N-Methylaspartate / Q000494:pharmacology*; D011712:Pyramidal Tracts / Q000502:physiology*; D011810:Quinoxalines / Q000494:pharmacology; D013569:Synapses / Q000187:drug effects / Q000502:physiology*; D013779:Tetrodotoxin / Q000494:pharmacology
D011810:Quinoxalines; D013779:Tetrodotoxin; D016202:N-Methylaspartate; D018750:6-Cyano-7-nitroquinoxaline-2,3-dione