Ferret red cells: Na/Ca exchange and Na-K-Cl cotransport.
The primary pathway for K influx in ferret red cells is the Na-K-Cl cotransporter and the primary pathway for Ca influx is the Na/Ca exchanger. This makes ferret red cells favorable models for the study of these two transport systems. The evidence that Na/Ca exchange is of primary importance for steady state cell volume regulation and the Na-K-Cl cotransport has a minor role is presented. The approaches to, and results of, the determination of the stoichiometry, of the mechanism, and of the regulation by ATP and Mg, for Na/Ca exchange is contrasted with that taken for Na-K-Cl cotransport.
Milanick
M A
MA
Department of Physiology, University of Missouri-Columbia 65212.
D000818:Animals; D002118:Calcium / Q000097:blood; D002352:Carrier Proteins / Q000097:blood*; D002712:Chlorides / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism*; D005289:Ferrets / Q000097:blood*; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D019831:Sodium-Calcium Exchanger; D028021:Sodium-Potassium-Chloride Symporters
D002352:Carrier Proteins; D002712:Chlorides; D019831:Sodium-Calcium Exchanger; D028021:Sodium-Potassium-Chloride Symporters; D012964:Sodium; D011188:Potassium; D002118:Calcium