What have tissue culture studies told us about the development of oligodendrocytes?
One major success of studying neural cell development in tissue culture has been the discovery of the O-2A cell. This bipotential cell generates oligodendrocytes or, under certain conditions, a type of astrocyte. This essay considers the evidence that the characteristic properties demonstrated by the O-2A cells in vitro are an accurate reflection of oligodendrocyte development in vivo.
National Institute for Medical Research, Mill Hill, London, UK.
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Williams
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D000818:Animals; D016477:Artifacts; D001253:Astrocytes / Q000166:cytology; D015415:Biomarkers; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D002642:Chick Embryo; D020934:Ciliary Neurotrophic Factor; D046508:Culture Techniques / Q000379:methods; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000494:pharmacology / Q000502:physiology; D009836:Oligodendroglia / Q000166:cytology*; D009900:Optic Nerve / Q000166:cytology; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology / Q000502:physiology; D051381:Rats; D013234:Stem Cells / Q000166:cytology* / Q000187:drug effects
D015415:Biomarkers; D020934:Ciliary Neurotrophic Factor; D009419:Nerve Tissue Proteins; D010982:Platelet-Derived Growth Factor