Identification and expression of the ACV synthetase gene.
The gene coding for ACV synthetase has recently been identified and cloned. Analysis of its structure and expression, along with similar studies of other genes involved in beta-lactam biosynthesis, should lead to a better understanding of the molecular basis of regulation of the pathway and the possibility of modifying yield and diversity of fungal antibiotics.
Molecular Genetics Unit, University of St. Andrews, Fife, U.K.
A P
AP
MacCabe
M B
MB
Riach
J R
JR
Kinghorn
D000900:Anti-Bacterial Agents / Q000096:biosynthesis; D001233:Aspergillus nidulans / Q000201:enzymology / Q000235:genetics*; D003001:Cloning, Molecular; D005656:Fungal Proteins / Q000096:biosynthesis / Q000235:genetics*; D005658:Fungi / Q000201:enzymology / Q000235:genetics; D015966:Gene Expression Regulation, Fungal; D005800:Genes, Fungal; D007769:Lactams; D010453:Peptide Synthases / Q000096:biosynthesis / Q000235:genetics*; D011993:Recombinant Fusion Proteins / Q000096:biosynthesis / Q000235:genetics
D000900:Anti-Bacterial Agents; D005656:Fungal Proteins; D007769:Lactams; D011993:Recombinant Fusion Proteins; D010453:Peptide Synthases; C095368:alpha-aminoadipyl-cysteinyl-valine synthetase