First prenatal diagnosis of X-linked lymphoproliferative disease.
A family study was performed in order to diagnose X-linked lymphoproliferative (XLP) disease in a fetus. The molecular genetic analysis indicated that the fetus, as well as its healthy 7-year-old brother, inherited XLP. Analysis of immunoglobulin subclasses from the 7-year-old brother supported the DNA-based diagnosis. This is the first XLP family of African descent.
Center for Human Genetics, Boston University School of Medicine, Massachusetts 02118.
J
J
Skare
S
S
Madan
J
J
Glaser
D
D
Purtilo
H
H
Nitowsky
V
V
Pulijaal
A
A
Milunsky
D001345:Autoradiography; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis* / Q000235:genetics; D008040:Genetic Linkage; D006579:Heterozygote; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000175:diagnosis* / Q000235:genetics; D008297:Male; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D011296:Prenatal Diagnosis; D014960:X Chromosome