[Histoenzymatic picture of rat gastric mucosa under the influence of dexamethasone].
White male [correction of female] rats were given Dexamethasone in a single dose 0.35 mg/24 hrs. Group I was given the drug once, group II--received it for 2 days, and group III--for 7 days. 24 hrs after the medicine had been given the mucous membrane of the stomach corpus was collected for examinations. There were performed: H+E staining, PAS reaction and histochemical reaction to the activity of ATP-ase, acid phosphatase and alkaline phosphatase. The results obtained were compared with those obtained in a group of control animals which were given distilled water. The administration of Dexamethasone did not affect significantly the activity of the examined hydrolases, however, it damaged the mucous barrier of the stomach, specially in the animals after 7 days of application of the drug.
Kifer-Wysocka
E
E
Katedra i Zakład Histologii i Embriologii, Akademia Medyczna w Lublinie.
Romanowska-Sarlej
J
J
Matysiak
W
W
Czerny
K
K
D000135:Acid Phosphatase / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D003907:Dexamethasone; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D000251:Adenosine Triphosphatases
Obraz histoenzymatyczny błony śluzowej zoładka szczura znajdujacego sie pod wpływem Dexamethasonu.