Interindividual variations in enzymes controlling organophosphate toxicity in man.
1 Interindividual variations in an unexposed population have been defined for five enzymes involved in organophosphate (OP) toxicity. The enzymes measured were: red blood cell acetylcholinesterase (AChE), lymphocyte neuropathy target esterase (NTE), serum cholinesterase (ChE), serum paraoxonase and serum arylesterase. 2 AChE and arylesterase were normally distributed in the population whilst the distribution of NTE, ChE and paraoxonase deviated significantly from normal. 3 Assay precision and intra-individual variability were measured for each of the enzymes; the effect on interindividual variation was assessed. 4 Variations in enzyme activities between individuals could have profound effects on susceptibility to OP toxicity. Prior determination of these enzymes may be predictive of susceptibility. 5 Lymphocyte NTE has some limitations as an indicator of exposure to neurotoxic OPs.
Toxicology Unit, Medical School, Newcastle University, UK.
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Mutch
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Blain
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Williams
D000110:Acetylcholinesterase / Q000097:blood; D000293:Adolescent; D000328:Adult; D043303:Aryldialkylphosphatase; D002265:Carboxylic Ester Hydrolases / Q000097:blood; D002802:Cholinesterases / Q000097:blood; D006801:Humans; D007206:Individuality; D008214:Lymphocytes / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D009943:Organophosphorus Compounds / Q000633:toxicity*; D010744:Phosphoric Monoester Hydrolases / Q000097:blood
D009943:Organophosphorus Compounds; D002265:Carboxylic Ester Hydrolases; C021859:neurotoxic esterase; C019734:arylesterase; D000110:Acetylcholinesterase; D002802:Cholinesterases; D010744:Phosphoric Monoester Hydrolases; D043303:Aryldialkylphosphatase