Multinucleate cell angiohistiocytoma.
We report a case of multinucleate cell angiohistiocytoma occurring in a 50-year-old woman and presenting with a 4-year history of asymptomatic red papules on the face. Histologically, there was a dermal vascular proliferation associated with numerous multinucleate cells. Immunohistochemical studies showed vascular spaces surrounded with mature vascular endothelial cells, and the presence of numerous interstitial factor XIIIa+ cells. Multinucleate cells exhibited intermediate filaments of the vimentin type, but were not stained by endothelial cell or macrophage markers, and were factor XIIIa-. This condition must be addressed in the differential diagnosis of other skin vascular proliferations, such as Kaposi's sarcoma and angiofibromas.
Department of Dermatology, University of Modena, Italy.
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G
Annessi
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Girolomoni
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Giannetti
D015496:CD4-Positive T-Lymphocytes / Q000473:pathology; D002196:Capillaries / Q000473:pathology; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D004817:Epidermis / Q000473:pathology; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000098:blood supply / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D012878:Skin Neoplasms / Q000098:blood supply / Q000473:pathology*; D014699:Venules / Q000473:pathology; D014746:Vimentin / Q000032:analysis
D014746:Vimentin