Prediction of drug resistance in human tumors using immunohistochemical techniques.
An in vitro chemosensitivity testing procedure based on the immunodetection of protein products which reflect the expression of various tumor resistance mechanisms is proposed. This protocol may be of predictive value in choosing drugs which should be selected for chemotherapy, and avoiding drugs which might be expected to be ineffective due to the enhanced expression of specific resistance factors.
German Cancer Research Center, Heidelberg, Germany.
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D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D002453:Cell Cycle; D004250:DNA Topoisomerases, Type II / Q000032:analysis; D004351:Drug Resistance; D005982:Glutathione Transferase / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008562:Membrane Glycoproteins / Q000032:analysis; D008780:Methyltransferases / Q000032:analysis; D009369:Neoplasms / Q000188:drug therapy*; D019853:O(6)-Methylguanine-DNA Methyltransferase; D013762:Tetrahydrofolate Dehydrogenase / Q000032:analysis; D013806:Theophylline / Q000378:metabolism; D013940:Thymidylate Synthase / Q000032:analysis
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D008562:Membrane Glycoproteins; D013806:Theophylline; D013762:Tetrahydrofolate Dehydrogenase; D008780:Methyltransferases; D013940:Thymidylate Synthase; D019853:O(6)-Methylguanine-DNA Methyltransferase; D005982:Glutathione Transferase; D004250:DNA Topoisomerases, Type II