Molecular design of cholera vaccines.
Cholera is still a serious public health problem in developing countries, particularly those in tropical regions. This has stimulated considerable research into the molecular analysis of pathogenesis resulting in the identification of a number of critical components required for both colonization of the gut mucosa and the disease symptoms. These components are the targets for rational molecular approaches to vaccine development.
Department of Microbiology and Immunology, University of Adelaide, South Australia.
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Manning
D001426:Bacterial Proteins / Q000276:immunology; D002771:Cholera / Q000517:prevention & control; D002772:Cholera Toxin / Q000276:immunology*; D022121:Cholera Vaccines; D003906:Developing Countries; D015195:Drug Design; D010861:Fimbriae, Bacterial / Q000276:immunology; D006801:Humans; D008070:Lipopolysaccharides / Q000276:immunology; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated; D014614:Vaccines, Synthetic; D014734:Vibrio cholerae / Q000235:genetics / Q000276:immunology
D001426:Bacterial Proteins; D022121:Cholera Vaccines; D008070:Lipopolysaccharides; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated; D014614:Vaccines, Synthetic; D002772:Cholera Toxin