[The content of gastrin, bombesin and somatostatin in the blood and gastric juice of patients with duodenal and gastric peptic ulcer].
Ninety patients suffering from peptic ulcer and 25 healthy subjects were examined for the content of gastrin, bombesin and somatostatin in blood and gastric juice. Among patients with duodenal ulcer, 2 groups were distinguished: group I included patients in whom peptic ulcer occurred before 30 years; the majority of the patients manifested blood hypergastrinemia, a decrease of bombesin concentration and normal somatostatin concentration; gastric juice was characterized by a lowering of somatostatin concentration and unchanged gastrin concentration; group II was made up of patients who developed peptic ulcer after 30: in the majority of the patients, gastrin concentration was reduced under basal conditions, after loading it was unchanged; in part of the patients, blood somatostatin concentration was elevated, in 16 in exacerbation and in 19 in remission; in the remainder, it was unchanged. The concentration of bombesin in blood remained unchanged. In gastric juice, gastrin concentration was increased only after histamine administration, somatostatin concentration was unchanged whatever the disease stage. In patients with gastric ulcer, gastrin concentration in blood was elevated only under basal conditions, being unchanged in gastric juice irrespective of the disease stage. Meanwhile, the concentration of bombesin was lowered both under basal conditions and after insulin administration, the concentration of somatostatin was decreased both in blood and gastric juice whatever the disease stage.
Loginov
A S
AS
Arbuzova
V G
VG
Astaf'eva
O V
OV
Amirov
N Sh
NSh
Zvenigorodskaia
L A
LA
D000328:Adult; D001839:Bombesin / Q000032:analysis*; D004381:Duodenal Ulcer / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005750:Gastric Juice / Q000737:chemistry*; D005755:Gastrins / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D013004:Somatostatin / Q000032:analysis*; D013276:Stomach Ulcer / Q000235:genetics / Q000378:metabolism*
D005755:Gastrins; D013004:Somatostatin; D001839:Bombesin
Soderzhanie gastrina, bombezina i somatostatina v krovi i zheludochnom soke bol'nykh iazvennoĭ bolezn'iu dvenadtsatiperstnoĭ kishki i zheludka.