A genetic map of the mouse suitable for typing intraspecific crosses.
We report the construction of a genetic linkage map of the mouse, consisting entirely of genetic markers that can be rapidly typed by polymerase chain reaction and that show a high degree of polymorphism among inbred laboratory strains. Specifically, the map contains 317 simple sequence length polymorphisms at an average spacing of 4.3 cM and is detectably linked to approximately 99% of the mouse genome. In typical crosses between inbred laboratory strains, about 50% of the markers are polymorphic, making it straightforward to follow inheritance in almost any cross.
Dietrich
W
W
Whitehead Institute for Biomedical Research, Cambridge Massachusetts 02142.
Katz
H
H
Lincoln
S E
SE
Shin
H S
HS
Friedman
J
J
Dracopoli
N C
NC
Lander
E S
ES
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D008040:Genetic Linkage; D005819:Genetic Markers; D016678:Genome; D051379:Mice / Q000235:genetics*; D008815:Mice, Inbred Strains / Q000235:genetics; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D012091:Repetitive Sequences, Nucleic Acid
D005819:Genetic Markers