[Anticancer substances of vegetable origin. Spindle poisons: vincaleukoblastine, leurocristine and navelbine; taxol and taxotere].
The biological activity of spindle poisons can easily be measured using an in vitro assay based on the interaction of these substances with their cellular "receptor": tubulin. The use of this assay led us to select Navelbine and Taxotere as antimitotic substances. These compounds, as well as their natural parents: vincaleucoblastine, leurocristine and taxol respectively, have been obtained by semi-synthesis using relatively abundant natural precursors as starting materials. This paper summarizes the preparation of these important anticancer drugs.
Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, Gif-sur-Yvette.
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Guéritte-Voegelein
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Guénard
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Potier
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000494:pharmacology*; D000077143:Docetaxel; D006801:Humans; D066298:In Vitro Techniques; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology; D008941:Spindle Apparatus / Q000187:drug effects*; D043823:Taxoids; D014747:Vinblastine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D014750:Vincristine / Q000494:pharmacology*; D000077235:Vinorelbine
D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D043823:Taxoids; D000077143:Docetaxel; D014750:Vincristine; D014747:Vinblastine; D017239:Paclitaxel; D000077235:Vinorelbine
Substances anticancéreuses d'origine végétale. Les poisons du fuseau: vincaleucoblastine, leurocristine et Navelbine; taxol et Taxotère.