Brave new proteins: what evolution reveals about protein structure.
Synthetic proteins provide important information about the principles of protein structure. They illuminate the processes of natural protein evaluation, but are not limited by these processes. Here, we review studies of several mutant proteins and discuss the general principles that can be derived from them.
Pastore
A
A
EMBL, Heidelberg, Germany.
Lesk
A M
AM
D000818:Animals; D005075:Biological Evolution; D006801:Humans; D009154:Mutation; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry / Q000235:genetics*
D011506:Proteins