Characterization of a subfamily of zinc finger genes expressed in human hematopoietic cell lines.
We isolated by low stringency screening of a human erythroleukemia cDNA library (K562) 45 independent clones hybridizing to a Krüppel-like (HF.10) zinc finger cDNA. The expression of 15 such cDNAs in human hematopoietic cell lines was investigated. Preliminary sequence analysis of the zinc finger motifs in these cDNAs indicate that they belong to a subclass of the Cys-Cys/His-His motif, showing the highest homology to the Wilm's tumor and EGR1, EGR2 cDNAs.
Munaro
M
M
Dipartimento di Genetica e Biologia dei Microrganismi, CNR, Milano.
Petroni
D
D
Di Fazio
M
M
Comi
P
P
Ottolenghi
S
S
D000595:Amino Acid Sequence; D003001:Cloning, Molecular; D015698:Genomic Library; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D012689:Sequence Homology, Nucleic Acid; D014407:Tumor Cells, Cultured; D016335:Zinc Fingers / Q000235:genetics*