Apraclonidine and argon laser trabeculoplasty.
Sixty patients with medically uncontrolled open-angle glaucoma (intraocular pressure greater than 21 mm Hg) were randomly assigned to one of two treatment regimens with apraclonidine before undergoing 360-degree argon laser trabeculoplasty. One drop of apraclonidine 1% was instilled one hour before and immediately after laser treatment in 30 eyes or apraclonidine was delivered only after trabeculoplasty in 30 eyes. Intraocular pressure before laser treatment, number of antiglaucoma medications, and the laser treatment settings were comparable between the two groups. The mean and percent change in intraocular pressures were similar in both treatment groups one and two hours after trabeculoplasty. One drop of apraclonidine 1% instilled immediately after argon laser trabeculoplasty prevented intraocular pressure increase one hour and two hours postoperatively as effectively as its instillation both one hour before and immediately after laser treatment.
Holmwood
P C
PC
Department of Ophthalmology, Northwestern University Medical School, Chicago, Illinois.
Chase
R D
RD
Krupin
T
T
Rosenberg
L F
LF
Ruderman
J M
JM
Tallman
B A
BA
Brodstein
D E
DE
Chopra
H
H
Goldenfeld
M
M
D000287:Administration, Topical; D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use*; D003000:Clonidine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D007429:Intraocular Pressure; D053685:Laser Therapy; D014130:Trabeculectomy
D000316:Adrenergic alpha-Agonists; C016986:apraclonidine; D003000:Clonidine