[Contribution of glutathione to detoxification in alcoholism. Biochemical-clinical studies].
The effects of reduced glutathione (GSH) administration (1.2 g/day and 2.4 g/day intravenously) on erythrocyte glutathione levels, serum gamma-glutamyl transpeptidase activity (GGTP) and urinary glucaric acid elimination were studied in a population of 24 chronic alcoholics voluntarily admitted to a 30 day detoxification protocol in comparison to a 12 patient control group treated only with chlordiazepoxide (initial dose 75-100 mg/day). Glutathione treatment increases dose-dependently and in a significant way erythrocyte glutathione levels and hastens the recovery of serum GGTP and urinary glucaric acid elimination. The relationship between glutathione, GGTP and glucaric acid is discussed, suggesting the possible role of GSH against the oxidative damage of alcohol.
Dipartimento di Farmacologia Preclinica e Clinica, Università degli Studi di Firenze.
A
A
Pistelli
P
P
Di Simplicio
M G
MG
Di Bello
S
S
Raspanti
F
F
Gambassi
P
P
Botti
L
L
Caramelli
S
S
Peruzzi
C
C
Smorlesi
A M
AM
Zorn
D000328:Adult; D000437:Alcoholism / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D002707:Chlordiazepoxide / Q000627:therapeutic use; D004912:Erythrocytes / Q000737:chemistry; D005260:Female; D005937:Glucaric Acid / Q000652:urine; D005978:Glutathione / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D005723:gamma-Glutamyltransferase / Q000097:blood
D002707:Chlordiazepoxide; D005723:gamma-Glutamyltransferase; D005978:Glutathione; D005937:Glucaric Acid
L'apporto di glutatione nella detossificazione dell'alcolismo. Indagini biochimico-cliniche.