Physiochemical interactions of praziquantel, oxamniquine and tablet excipients.
A differential scanning calorimetry and infrared spectrophotometry study of potential interactions between oxamniquine and praziquantel, two synergistic anti-parasitic drugs, indicated that they did not interact on fusion. Mixtures of the two drugs with each of nine common pharmaceutical excipients (Ac-Di-Sol, Avicel, Crospovidone, calcium phosphate, magnesium stearate, starch, lactose, PEG 6000, stearic acid) appeared to interact only with stearic acid. These results suggested that a combination solid dosage form was feasible.
Prankerd
R J
RJ
Department of Pharmaceutics, College of Pharmacy, University of Florida, J. Hillis Miller Health Center, Gainesville 32610.
Ahmed
S M
SM
D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004055:Differential Thermal Analysis; D005079:Excipients; D010073:Oxamniquine / Q000737:chemistry*; D011223:Praziquantel / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013228:Stearates / Q000737:chemistry; D013607:Tablets
D005079:Excipients; D013228:Stearates; D013607:Tablets; D010073:Oxamniquine; D011223:Praziquantel