Inhibitory effect of acylphloroglucinol derivatives on the replication of vesicular stomatitis virus.
The antiviral activity of natural phloroglucinols and of synthesized mono- and diacylphloroglucinols, and 2,6-diacyl-4,4-dialkylcyclohexa-1,3,5-triones was investigated. A correlation between the acyl chain length and inhibitory activity against vesicular stomatitis virus (VSV) was observed. Potent antiviral activity was found in di-isovalerylphoroglucinol. 2,6-Diacyl-4,4-dialkylcyclohexa-1,3,5-triones inhibited replication of the virus with low cytotoxicity.
Laboratory of Bio-organic Chemistry, Tokyo University of Agriculture and Technology, Japan.
K
K
Chiba
T
T
Takakuwa
M
M
Tada
T
T
Yoshii
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D001709:Biotechnology; D002460:Cell Line; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D011817:Rabbits; D013329:Structure-Activity Relationship; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects* / Q000502:physiology; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D010696:Phloroglucinol