Psychoneuroendocrinoimmunology: the basis for a novel therapeutic approach in aging.
Along with the nervous and the endocrine systems, the immune system is one of the three major integrative systems in higher organisms. Growing evidence demonstrates an intimate relationship between the immune system and the endocrine and nervous systems: The psychoneuroendocrine system can influence the immune response and thereby the capacity of the organism to cope with illness, and the immune system can have an impact on neuroendocrine function. Such cross-talk among systems is dependent upon feedback loops working to maintain homeostatic equilibrium.
Scapagnini
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Institute of Pharmacology, University of Catania School of Medicine, Italy.
D000324:Adrenocorticotropic Hormone / Q000502:physiology; D000375:Aging / Q000276:immunology*; D000818:Animals; D001143:Arousal / Q000502:physiology; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy; D005246:Feedback; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D007108:Immune Tolerance / Q000276:immunology; D007111:Immunity, Cellular / Q000502:physiology; D007121:Immunocompetence / Q000502:physiology*; D007375:Interleukin-1 / Q000502:physiology; D009490:Neurosecretory Systems / Q000503:physiopathology*; D018377:Neurotransmitter Agents / Q000502:physiology; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D011598:Psychoneuroimmunology; D051381:Rats
D007375:Interleukin-1; D018377:Neurotransmitter Agents; D000324:Adrenocorticotropic Hormone