Effect of H1-receptor blockade on anthralin inflammation.
The effect of terfenadine, an H1-receptor antagonist, on anthralin inflammation was studied in 12 subjects. Subjects were randomised to receive terfenadine 60 mg or placebo b.d. in a double-blind, cross-over study. Anthralin 5, 10 and 20 micrograms in 10 microliters chloroform was pipetted onto flexor forearm skin. Anthralin inflammatory oedema and erythema were measured using Harpenden calipers and a reflectance photometer, 48 h after anthralin application. After a 3-day washout period, placebo and terfenadine were restarted and the procedures repeated on the opposite arm. Anthralin erythema and oedema increased with dose but the dose-response curves showed no significant difference with or without terfenadine (p greater than 0.05). This study shows that H1-receptor blockade does not inhibit anthralin inflammation.
Speight
E L
EL
Department of Dermatology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK.
Ramsay
B
B
Lawrence
C M
CM
D000328:Adult; D000368:Aged; D000875:Anthralin / Q000009:adverse effects; D003872:Dermatitis / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016593:Terfenadine / Q000627:therapeutic use
D006634:Histamine H1 Antagonists; D016593:Terfenadine; D000875:Anthralin