New perspectives on catalytic antibodies.
This review will give examples of the structure-function relationships used in the design of catalytic antibodies, including not only ligand or hapten-based approaches but also recent developments in the generation of catalytic antibodies through protein engineering. Last, a thermodynamic analysis is presented, which confirms that some antibodies do indeed catalyze their transformations by stabilizing transition states.
Jacobs
J W
JW
Department of Chemistry and Biochemistry, University of Colorado, Boulder 80309-0215.
D000906:Antibodies / Q000378:metabolism; D002384:Catalysis; D008024:Ligands; D015202:Protein Engineering; D013329:Structure-Activity Relationship; D013816:Thermodynamics
D000906:Antibodies; D008024:Ligands