[Expression of low-affinity Fc epsilon receptors on circulating monocytes in patients with inflammatory rheumatic diseases].
In patients with scleroderma, high proportions of circulating CD23+ monocytes could be detected by FACS analysis as compared with controls. Supernatants obtained from lymphocytes yielded high amounts of interleukin-4-(IL-4-)like activity. The results suggest that IL-4 contributes to monocyte activation in scleroderma. There were no correlations with serum IgE, or numbers of naive and memory-CD4+ lymphocytes.
Medizinische Klinik III und Poliklinik, Universität Giessen.
H
H
Becker
P
P
Potyka
A
A
Langrock
T
T
Discher
K
K
Federlin
D000944:Antigens, Differentiation, B-Lymphocyte / Q000378:metabolism*; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism; D006801:Humans; D015847:Interleukin-4 / Q000096:biosynthesis; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D009000:Monocytes / Q000378:metabolism*; D011961:Receptors, Fc / Q000378:metabolism*; D017455:Receptors, IgE; D012595:Scleroderma, Systemic / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D000944:Antigens, Differentiation, B-Lymphocyte; D011961:Receptors, Fc; D017455:Receptors, IgE; D015847:Interleukin-4
Expression niedrig-affiner Fc epsilon-Rezeptoren auf zirkulierenden Monozyten bei Patienten mit entzündlich-rheumatischen Erkrankungen.