Deletions, fusions and domain rearrangements.
The techniques of protein engineering are proving to be powerful analytical tools for the study of the structure and function of complex multidomain proteins. In particular, the overexpression of individual functional modules is providing proteins for three-dimensional structural analyses. Progress is also being made in the design and construction of novel multidomain proteins with potential therapeutic applications.
Coggins
J R
JR
Department of Biochemistry, University of Glasgow, Scotland, UK.
D000818:Animals; D002872:Chromosome Deletion; D003001:Cloning, Molecular; D006801:Humans; D015202:Protein Engineering; D011506:Proteins / Q000737:chemistry / Q000235:genetics
D011506:Proteins