Proton relaxation NMR study of polycrystalline progesterone.
Polycrystalline progesterone (4-pregnene-3,20-dione, C21H30O2) has been investigated by proton NMR methods between 80 and 350 K. A reduction in dipolar second moment is ascribed to methyl group reorientation. Minima in the spin-lattice relaxation time found in measurements at five frequencies from 7 to 200 MHz are attributed to reorientation of two of the three methyl groups in each molecule, characterized by activation energy Ea = 10.9 +/- 0.8 kJ/mol and tau o = (2.3 +/- 0.2) x 10(-13) s. Additional relaxation at lower temperatures is attributed to reorientation of the third methyl group with Ea approximately 3.4 kJ/mol. Measurements were also made of relaxation in the rotating frame.
Department of Physics, University of Florida, Gainesville, 32611.
E R
ER
Andrew
K
K
Jurga
J M
JM
Radomski
E C
EC
Reynhardt
D003460:Crystallization; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008956:Models, Chemical; D015394:Molecular Structure; D011374:Progesterone / Q000737:chemistry*; D011522:Protons; D013696:Temperature; D013816:Thermodynamics
D011522:Protons; D011374:Progesterone