Dominant hemimelia and En-1 on mouse chromosome 1 are not allelic.
Previous studies have shown that En-1, a homeobox-containing gene, maps close to or at the Dh locus in the mouse. Since homeobox-containing genes are key genes in the control of development the close proximity of En-1 to the developmentally significant gene Dh raised the possibility that the Dh mutation represented a mutant allele of En-1. A genetic analysis involving En-1, Dh, and other chromosome 1 markers (Emv-17, ln and Pep-3) shows that although Dh and En-1 are closely linked they are separable by recombination (4/563). The likely gene order and recombination frequencies of these loci are: ln (5.2 +/- 0.9) Emv-17 (1.1 +/- 0.4) Dh (0.7 +/- 0.4) En-1 (3.0 +/- 0.7) Pep-3. This shows that Dh is not a mutant allele of En-1.
Higgins
M
M
MRC Human Genetics Unit, Edinburgh, UK.
Hill
R E
RE
West
J D
JD
D000818:Animals; D002874:Chromosome Mapping; D000013:Congenital Abnormalities / Q000235:genetics; D005260:Female; D005799:Genes, Dominant; D005801:Genes, Homeobox; D008040:Genetic Linkage; D005819:Genetic Markers; D017880:Limb Deformities, Congenital; D008297:Male; D051379:Mice / Q000235:genetics*; D008817:Mice, Mutant Strains / Q000235:genetics*; D010641:Phenotype; D011995:Recombination, Genetic
D005819:Genetic Markers