Synergistic effect of Adh alleles in Drosophila melanogaster.
In laboratory cultures of Drosophila melanogaster derived from an African population, the quantities of six out of seven enzymes (G6PD, IDH, GPDH, ME, MDH, PGM and ADH) were higher in Adh-FF homozygotes than they were in Adh-SS. In crosses between Adh-FF and Adh-SS flies, the differences segregated as co-dominant alleles of a single Mendelian gene closely linked, or identical, to the Adh locus. The generality of these associations was suggested by the study of a French population with a very different history and genetic background. The possibility that the associations were caused by artefacts of the immunodiffusion techniques, or to a linked inversion (In(2L)t), was excluded. Possible ways by which the Adh locus may affect the quantities of other enzymes are discussed.
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Department of Genetics, Queen's Medical Centre, University of Nottingham, U.K.
D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004331:Drosophila melanogaster / Q000201:enzymology / Q000235:genetics*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics; D005993:Glycerolphosphate Dehydrogenase / Q000235:genetics; D007521:Isocitrate Dehydrogenase / Q000235:genetics; D008291:Malate Dehydrogenase / Q000235:genetics; D008297:Male; D010733:Phosphoglucomutase / Q000235:genetics
D005993:Glycerolphosphate Dehydrogenase; D000426:Alcohol Dehydrogenase; D008291:Malate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D010733:Phosphoglucomutase