Neurotoxicity related to lithium and neuroleptic combinations? A retrospective review.
The question of toxic interactions resulting from combinations of lithium and neuroleptic drugs is largely based on anecdotal reports. We replicated the methods of Miller and Menninger (1987) who reported that 27% of manic patients on treatment with lithium and neuroleptics developed toxicity. We found no cases of neurotoxicity as defined in the earlier report. Pharmacologic mechanisms and differences in the clinical findings of the two studies are discussed.
Department of Psychiatry, Medical College of Pennsylvania, Philadelphia 19129.
J B
JB
Kessel
C
C
Verghese
G M
GM
Simpson
D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D016651:Lithium Carbonate / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D011605:Psychoses, Substance-Induced / Q000097:blood / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors
D014150:Antipsychotic Agents; D016651:Lithium Carbonate