[Various indicators of the hormonal profile in patients with neuroses after psychopharmacotherapy and functional test with sinacten].
Studies of adenohypophyseal hormones, cortisol, T3, T4, thyroxine-binding globulin, testosterone, progesterone and estradiol in 90 neurotic men, treated or not with amitriptyline and benzodiazepines, allowed a conclusion that in the majority of them, endocrine functions were activated. 11 healthy men and 11 male patients underwent the three-day test with sinacten-depot (1 mg intramuscularly). The functional test data were compared over time by the methods of nonparametric statistics. The patients manifested a decrease of reserve potentialities of the pituitary-adrenal system, redistribution of the fractions of thyroid hormones, gonadotropins, the progesterone/estradiol ratio, a rise of prolactin and testosterone secretion. The drugs were found to improve the functioning of the pituitary-adrenal system. However, they did not contribute much to the positive changes in the pituitary-thyroid and other systems.
Tkachev
A V
AV
Parniakov
A V
AV
Sukhanov
S G
SG
Ramenskaia
E B
EB
D000305:Adrenal Cortex Hormones / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000328:Adult; D000639:Amitriptyline / Q000627:therapeutic use*; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001569:Benzodiazepines; D003366:Cosyntropin / Q000494:pharmacology; D003692:Delayed-Action Preparations; D004958:Estradiol / Q000378:metabolism*; D006728:Hormones / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009497:Neurotic Disorders / Q000188:drug therapy* / Q000503:physiopathology; D010908:Pituitary Hormones, Anterior / Q000378:metabolism*; D010913:Pituitary-Adrenal System / Q000187:drug effects* / Q000503:physiopathology; D013961:Thyroid Gland / Q000187:drug effects* / Q000503:physiopathology; D013963:Thyroid Hormones / Q000378:metabolism*
D000305:Adrenal Cortex Hormones; D014151:Anti-Anxiety Agents; D003692:Delayed-Action Preparations; D006728:Hormones; D010908:Pituitary Hormones, Anterior; D013963:Thyroid Hormones; D001569:Benzodiazepines; D003366:Cosyntropin; D000639:Amitriptyline; D004958:Estradiol; D000324:Adrenocorticotropic Hormone
Nekotorye pokazateli gormonal'nogo profilia u bol'nykh nevrozami na fone psikhofarmakoterapii i funktsional'noĭ nagruzki sinaktenom.