Role of dopamine receptors in the regulation of aggression in mice; relationship to genotype.
The interline differences in the manifestation of aggression evoked by stimulation was studied in mice of eight inbred lines, and the role of different types of dopamine (DA) receptors in its manifestation was investigated. Aggression was assessed in a test involving the effect of a weak electrical stimulation through the floor of the cage. A significant relationship to the animals' genotype was demonstrated, and low-aggression (C3h/He, DD, BALB/c, and AKR) and high-aggression (CBA, DBA/2, and CC57Br) lines could be distinguished on the basis of the level of aggressivity. The mixed agonist of DA receptors, apomorphine, in a one-time administration activated aggressivity in the low-aggression mice. The selective stimulation of D2-receptors with bromocriptine substantially increased the evoked aggressivity in the low-aggression mice; the blockade of D2-receptors by sulpiride decreased or prevented the manifestation of aggressivity in the high-aggression lines. At the same time, the selective D1-agonist SKF 38393 and the selective D1-antagonist SCH 23390 did not exert a substantial influence on evoked aggressivity. Evidently the D2-receptors play a key role in the control of aggression evoked by stimulation, which constitutes a model of affective aggression.
Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk.
E M
EM
Nikulina
N S
NS
Kapralova
D000374:Aggression / Q000502:physiology*; D000818:Animals; D015259:Dopamine Agents / Q000494:pharmacology; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D004558:Electric Stimulation; D005838:Genotype; D051379:Mice; D008815:Mice, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors / Q000187:drug effects; D017448:Receptors, Dopamine D2 / Q000187:drug effects; D013045:Species Specificity
D015259:Dopamine Agents; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2