Nodular hyperplasia, black thyroid, and chronic minocycline ingestion in a teenager.
An 18-year-old man with left-lobe thyroid hemiagenesis underwent isthmectomy for management of a nodule that failed to take up radioactive iodine during a nuclear scan. The resected tissue, which demonstrated nodular hyperplasia, and the remaining right lobe, were black. The association between deep staining and chronic minocycline ingestion was subsequently recognized. Twelve years later, the patient remained asymptomatic, suggesting that complete resection of tetracycline-stained thyroid tissue is unnecessary.
Department of Surgery, Case Western Reserve University School of Medicine, Cleveland, Ohio.
D L
DL
Folsom
M W
MW
Gauderer
W T
WT
Dahms
D000152:Acne Vulgaris / Q000188:drug therapy; D000293:Adolescent; D006485:Hemosiderin / Q000032:analysis; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008854:Microscopy, Electron; D008911:Minocycline / Q000009:adverse effects*; D010859:Pigmentation Disorders / Q000139:chemically induced* / Q000150:complications; D013961:Thyroid Gland / Q000002:abnormalities / Q000187:drug effects* / Q000473:pathology; D016606:Thyroid Nodule / Q000150:complications* / Q000175:diagnosis / Q000601:surgery
D006485:Hemosiderin; D008911:Minocycline