Ranitidine, cimetidine, famotidine have no effect on post-prandial absorption of ethanol 0.8 g/kg taken after an evening meal.
Forty-seven healthy male subjects were studied twice using a randomized, placebo-controlled design. Each subject took an 8-day course of two of the following four regimens; 300 mg ranitidine, 800 mg cimetidine, 40 mg famotidine or placebo (identical either to 300 mg ranitidine or 800 mg cimetidine). The systemic bioavailability of ethanol (integrated 6-h plasma ethanol concentration, peak plasma ethanol concentration, and the time to peak plasma ethanol concentration) was measured after the oral ingestion of 0.8 g of ethanol per kg body weight, given one hour after an evening meal on Day 8 of each regimen. There was no significant difference of integrated 6-h plasma ethanol concentration, peak ethanol concentration, or time to reach peak ethanol concentration after dosing with either ranitidine, cimetidine or famotidine or placebo.
University Department of Medicine, Royal Free Hospital School of Medicine, London, UK.
A G
AG
Fraser
M
M
Hudson
A M
AM
Sawyerr
M
M
Smith
S B
SB
Rosalki
R E
RE
Pounder
D000042:Absorption / Q000187:drug effects; D000328:Adult; D001682:Biological Availability; D002927:Cimetidine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004347:Drug Interactions; D004435:Eating; D000431:Ethanol / Q000097:blood / Q000493:pharmacokinetics*; D015738:Famotidine / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011899:Ranitidine / Q000494:pharmacology
D006635:Histamine H2 Antagonists; D000431:Ethanol; D015738:Famotidine; D002927:Cimetidine; D011899:Ranitidine