Immunoreactivity for P-170 glycoprotein in malignant mesothelioma and in non-neoplastic mesothelium of the pleura using the murine monoclonal antibody JSB-1.
The results of an immunohistochemical study of P-170 glycoprotein immunoreactivity in human non-neoplastic mesothelium (35 cases) and in malignant mesothelioma (33 cases) using the murine monoclonal antibody JSB-1 are reported. The majority of malignant mesothelioma cases exhibited cytoplasmic and membrane immunoreactivity in neoplastic cells. These findings are highly significant when compared with the absence of immunoreactivity in normal mesothelium.
Department of Pathology, University Hospital Antwerp, University of Antwerp, Belgium.
M
M
Ramael
J
J
van den Bossche
C
C
Buysse
J
J
van Meerbeeck
K
K
Segers
P
P
Vermeire
E
E
van Marck
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000818:Animals; D000911:Antibodies, Monoclonal; D004848:Epithelium / Q000737:chemistry*; D006801:Humans; D007150:Immunohistochemistry; D008562:Membrane Glycoproteins / Q000032:analysis*; D008654:Mesothelioma / Q000737:chemistry* / Q000473:pathology; D051379:Mice; D009363:Neoplasm Proteins / Q000032:analysis*; D010997:Pleural Neoplasms / Q000737:chemistry* / Q000473:pathology
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000911:Antibodies, Monoclonal; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins