Ciprofloxacin for treatment of malakoplakia.
The tumour-like lesions of the rare disease malakoplakia, which consist of macrophages containing undigested coliform bacteria, are often misdiagnosed as a carcinoma. Although an infectious aetiology is likely, no antimicrobial therapy has been successful in the long-term. Since ciprofloxacin penetrates well into macrophages, this drug was given to two patients with advanced malakoplakia (500 mg twice daily). After long-term treatment all granulomatous lesions disappeared. Thus, malakoplakia can be cured by antibiotic treatment.
Department of Infectious Diseases, University Hospital Leiden, Netherlands.
R
R
van Furth
J W
JW
van't Wout
P A
PA
Wertheimer
J
J
Zwartendijk
D000328:Adult; D002939:Ciprofloxacin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D006801:Humans; D008264:Macrophages / Q000187:drug effects / Q000382:microbiology; D008287:Malacoplakia / Q000188:drug therapy* / Q000601:surgery; D008875:Middle Aged; D009392:Nephrectomy; D014515:Ureteral Diseases / Q000188:drug therapy* / Q000601:surgery; D001745:Urinary Bladder Diseases / Q000188:drug therapy* / Q000601:surgery
D002939:Ciprofloxacin