Cystic fibrosis--the way forward from the gene.
Cloning of the cystic fibrosis (CF) gene and elucidation of the physiological functions of the encoded protein is a triumph, not only for molecular biology, but also for people affected by CF. For them, not only is there now the possibility of screening for the commonest mutations, but they may also look forward to the prospect of improved therapies being developed.
MRC Human Genetics Unit, Edinburgh, UK.
J R
JR
Dorin
D J
DJ
Porteous
D000818:Animals; D003550:Cystic Fibrosis / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D004195:Disease Models, Animal; D005260:Female; D005820:Genetic Testing; D015316:Genetic Therapy; D005838:Genotype; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics; D010641:Phenotype; D011247:Pregnancy; D011296:Prenatal Diagnosis
C505032:CFTR protein, human; D008565:Membrane Proteins; D019005:Cystic Fibrosis Transmembrane Conductance Regulator