Fatal neutropenic enterocolitis associated with sulphasalazine therapy for rheumatoid arthritis.
Neutropenia is a recognized complication of sulphasalazine therapy in patients with rheumatoid arthritis. It is usually mild, transient and rarely associated with serious sequelae. We describe a patient with rheumatoid arthritis who developed fatal neutropenic enterocolitis complicated by tracheo-oesophageal fistula following treatment with sulphasalazine.
Department of Rheumatology, Norfolk and Norwich Hospital.
K
K
Chakravarty
D G
DG
Scott
B G
BG
McCann
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D004760:Enterocolitis / Q000139:chemically induced* / Q000150:complications; D006801:Humans; D008297:Male; D009503:Neutropenia / Q000139:chemically induced* / Q000150:complications; D012460:Sulfasalazine / Q000009:adverse effects* / Q000627:therapeutic use*
D012460:Sulfasalazine