Adsorption of paracetamol and chloroquine phosphate by some antacids.
The adsorption of paracetamol and chloroquine phosphate onto some antacids with adsorptive properties, has been studied. Dissolution of the drugs from commercial tablets was significantly retarded in the presence of the antacids. The adsorption and retardation of dissolution of both drugs by the adsorbent antacids studied followed the rank order magnesium trisilicate greater than magnesium oxide greater than aluminium hydroxide greater than edible clay. The concomitant administration of the drugs and antacid formulations containing any of these should be discouraged.
Iwuagwu
M A
MA
School of Pharmacy, University of Benin, Nigeria.
Aloko
K S
KS
D000082:Acetaminophen / Q000737:chemistry*; D000327:Adsorption; D000863:Antacids / Q000494:pharmacology*; D002738:Chloroquine / Q000031:analogs & derivatives* / Q000737:chemistry; D004347:Drug Interactions; D012995:Solubility
D000863:Antacids; D000082:Acetaminophen; C023676:chloroquine diphosphate; D002738:Chloroquine