Premature menarche--a legend or a defined clinical syndrome.
The properness of diagnosing the premature menarche as isolated clinical syndrome is often questioned. A long-term observation od 2 girls with premature menarche has been described. A discussion is presented about the role of imbalance within the hypothalamus-pituitary-gonads axis and the role of disturbances in peripheral responsiveness to sex hormones in the patho-mechanism of premature menarche.
Department of Pediatric Endocrinology, Institute of Endocrinology, Medical Academy of Lódź.
J
J
Zarzycki
A
A
Pawlikowska-Haddal
M
M
Hilczer
H
H
Domagalska-Nalewajek
D000365:Age Determination by Skeleton; D001827:Body Height; D001846:Bone Development; D002657:Child Development / Q000502:physiology; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007986:Luteinizing Hormone / Q000097:blood; D008572:Menarche / Q000502:physiology*; D011629:Puberty, Precocious / Q000175:diagnosis* / Q000503:physiopathology
D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone