[Anticancer substances of vegetable origin. Spindle poisons: vincaleukoblastine, leurocristine and navelbine; taxol and taxotere].
The biological activity of spindle poisons can easily be measured using an in vitro assay based on the interaction of these substances with their cellular "receptor": tubulin. The use of this assay led us to select Navelbine and Taxotere as antimitotic substances. These compounds, as well as their natural parents: vincaleucoblastine, leurocristine and taxol respectively, have been obtained by semi-synthesis using relatively abundant natural precursors as starting materials. This paper summarizes the preparation of these important anticancer drugs.
Guéritte-Voegelein
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F
Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, Gif-sur-Yvette.
Guénard
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D
Potier
P
P
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000494:pharmacology*; D000077143:Docetaxel; D006801:Humans; D066298:In Vitro Techniques; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology; D008941:Spindle Apparatus / Q000187:drug effects*; D043823:Taxoids; D014747:Vinblastine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D014750:Vincristine / Q000494:pharmacology*; D000077235:Vinorelbine
D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D043823:Taxoids; D000077143:Docetaxel; D014750:Vincristine; D014747:Vinblastine; D017239:Paclitaxel; D000077235:Vinorelbine
Substances anticancéreuses d'origine végétale. Les poisons du fuseau: vincaleucoblastine, leurocristine et Navelbine; taxol et Taxotère.