[Thrombosis prophylaxis using plasmin and its combination with alpha-adrenoreceptor antagonists].
Using two models of experimental thrombosis (arterio-venous shunt and Wessler's model) the effect of plasmin and its combination with alpha-adrenoreceptor antagonists on the formation of thrombus was studied on white rats. It was established that the efficacy of prophylactic of thrombosis by plasmin only was low: middle ball of thrombosis was 2.5-3.0. The combination of plasmin with alpha-adrenoblockers dihydroergotoxine or prazosin under these conditions is most efficient against the formation of thrombus (middle ball of thrombus in this case was 0.8-1.1). Prazosin under certain conditions have some advantages.
Grigoréva
M E
ME
Kalishevskaia
T M
TM
Golubeva
M G
MG
D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D000818:Animals; D004088:Dihydroergotoxine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005341:Fibrinolysin / Q000627:therapeutic use*; D008954:Models, Biological; D011224:Prazosin / Q000627:therapeutic use*; D051381:Rats; D013927:Thrombosis / Q000517:prevention & control*
D000317:Adrenergic alpha-Antagonists; D004088:Dihydroergotoxine; D005341:Fibrinolysin; D011224:Prazosin
Profilaktika tromboobrazovaniia s pomoshchíu plasmina i ego kombinatsiĭ s a-adrenoblokatorami.