Perspectives on the development of anti-HIV vaccines.
Progress towards the development of a vaccine against acquired immune deficiency syndrome is proceeding along several fronts. First and foremost, it rests on the basic research being done with the virus, particularly its mechanisms of replication, pathogenesis and evolution. More directly, progress comes from studies of animal models with the simian and human immunodeficiency viruses where vaccine candidates have proven effective in blocking infection. Principally because the animal models cannot answer all of the critical questions that apply to a vaccine for man, parallel studies in human volunteers have been initiated.
Bolognesi
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Duke Centre for AIDS Research, Duke University Medical Center, Durham, North Carolina 27710.
D016915:AIDS Vaccines; D000818:Animals; D015658:HIV Infections / Q000517:prevention & control* / Q000628:therapy; D006801:Humans; D002679:Pan troglodytes; D015302:Simian Immunodeficiency Virus
D016915:AIDS Vaccines