Antihistaminic activity of quinethindole: a 2-substituted pyrazinopyridoindole derivative.
Quinethindole, a 2-substituted pyrazinopyridoindole, showed specific antihistaminic (H1) activity in various in vivo and in vitro test models. It also inhibited antigen-induced contraction of ileum of sensitized guinea pig. The antihistaminic activity was of competitive nature.
Patnaik
G K
GK
Central Drug Research Institute, Lucknow, India.
Saxena
A K
AK
Saxena
M
M
Srimal
R C
RC
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D005260:Female; D006168:Guinea Pigs; D006325:Heart Atria / Q000187:drug effects; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D011738:Pyrilamine / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology*
D006634:Histamine H1 Antagonists; D007211:Indoles; D011804:Quinolines; C076605:quinethindole; D011738:Pyrilamine