Racial differences in coagulation studies in stroke.
Racial differences in stroke are known to exist with persons in the black race having a higher morbidity, mortality and incidence of stroke compared to whites. We evaluated coagulation factors in black and white stroke patients and compared the results between races. D-dimer was elevated more frequently in blacks than whites to a statistically significant degree. There were non-significant trends for blacks to have a positive lupus anticoagulant, low protein C and protein S, higher platelet factor 4, and hyporesponsive platelets to 10 microM epinephrine. The significance of these findings in understanding racial differences in stroke is discussed.
Gaines
K J
KJ
Department of Neurology, University of Tennessee, Memphis 38163.
Chesney
C
C
Vander Zwaag
R
R
Cape
C
C
D000368:Aged; D000990:Antithrombin III / Q000032:analysis; D044383:Black People; D001777:Blood Coagulation; D002561:Cerebrovascular Disorders / Q000097:blood*; D005260:Female; D005337:Fibrin / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D010978:Platelet Factor 4 / Q000032:analysis; D011486:Protein C / Q000032:analysis; D012016:Reference Values; D044465:White People
D011486:Protein C; D010978:Platelet Factor 4; D000990:Antithrombin III; D005337:Fibrin; D005340:Fibrinogen