In utero transplantation of stem cells in humans: technical aspects and clinical experience during pregnancy.
Four fetal patients have received fetal liver cell transplants in utero, at the fertilization ages of 12-28 weeks. Depending on the age, intraperitoneal injection or intravenous infusion into the umbilical vein was used, under ultrasonic guidance. In three of the four cases, engraftment has been obtained and has resulted in cure or significant improvement of the inherited disease.
Department of Gynecology and Obstetrics A, Hôpital de l'Hôtel-Dieu, Lyon, France.
D
D
Raudrant
J L
JL
Touraine
A
A
Rebaud
D016913:Blood Component Transfusion; D001805:Blood Transfusion, Intrauterine; D002678:Chimera; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005315:Fetal Diseases / Q000175:diagnosis / Q000628:therapy*; D016332:Fetal Tissue Transplantation; D005865:Gestational Age; D006085:Graft Survival; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis / Q000628:therapy*; D007231:Infant, Newborn; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous / Q000009:adverse effects; D008099:Liver / Q000196:embryology; D016031:Liver Transplantation; D008297:Male; D011247:Pregnancy; D011296:Prenatal Diagnosis; D016511:Severe Combined Immunodeficiency / Q000175:diagnosis / Q000628:therapy; D013789:Thalassemia / Q000175:diagnosis / Q000628:therapy*; D014471:Umbilical Veins