Receptor "families" for 5-hydroxytryptamine.
Significant advances in the analysis of 5-hydroxytryptamine (5-HT) receptor subtypes occurred in the 1980s. Although the current status of 5-HT receptor pharmacology may appear confusing to many investigators, the evolving data suggest that 5-HT receptor subtypes can be categorized into three major "families." Each "family" consists of multiple receptor subtypes that share similarities in their molecular, biological, pharmacological, biochemical, and/or physiological properties. These receptor subtypes are present throughout the nervous system as well as in the periphery. A simple framework for the classification of 5-HT receptor subtypes is provided in the present review.
Department of Neurology, Stanford University, California 94305, USA.
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Peroutka
D000818:Animals; D006801:Humans; D005810:Multigene Family; D011985:Receptors, Serotonin / Q000145:classification* / Q000187:drug effects / Q000235:genetics; D014666:Vasomotor System / Q000502:physiology*
D011985:Receptors, Serotonin