[Preliminary data on possibilities for the early detection of risk for primary liver carcinoma in chronic HBsAg carriers].
The investigations on the risk of hepatocarcinogenesis in the HBsAg chronic carriers have suggested that the early detection of primary liver carcinoma requires epidemiological and laboratory follow up of their state of health. The preliminary results of the comparative investigations of 103 HBsAg carriers detected among blood donors and 93 controls without HBsAg are presented. Epidemiological inquiries, clinical examinations and laboratory tests (HBsAg, serum alpha-fetoprotein, alkaline phosphatase, gamma-glutamyltranspeptidase, glutamic-pyruvic transaminase, proteinogram, siderophilin, immunoglobulins M, A, G) were carried out. Elevated levels of alpha-fetoprotein, alkaline phosphatase and gamma- glutamyltranspeptidase were recorded in carriers as compared to controls (38.8% and 86%, respectively). The elevation of the levels of liver damage markers was significantly correlated, in the HBsAg carriers, with the carrier state over 3 years and less with the age-group. In the case of two carriers with elevated levels of alpha-fetoprotein (> 600-> 1,000 ng/ml) ultrasonography confirmed the suspicion of primary liver carcinoma.
Institutul de Sănătate Publică si Cercetări Medicale Iaşi Universitatea de Medicină şi Farmacie Iaşi.
A
A
Ungureanu
A
A
Ivan
S
S
Tiron
I
I
Mitroi
D000328:Adult; D015415:Biomarkers / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000453:epidemiology; D002353:Carrier State / Q000175:diagnosis* / Q000453:epidemiology; D002908:Chronic Disease; D005260:Female; D006509:Hepatitis B / Q000175:diagnosis* / Q000453:epidemiology; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012383:Romania / Q000453:epidemiology; D013997:Time Factors
D015415:Biomarkers; D006514:Hepatitis B Surface Antigens
Date preliminare asupra posibilităţilor depistării precoce a riscului de carcinom hepatic primar la purtătorii cronici de AgHBs.