A model of the adrenergic beta-2 receptor and binding sites for agonist and antagonist.
From the known experimental data on adrenergic ligands and beta-2 receptor a model for the ligand binding sites was proposed and built. Agonist and antagonist have overlapping but different binding sites. The model correlates well with the structural information known from a series of adrenergic ligands.
Glaxo Group Research Ltd., Ware, Herts., United Kingdom.
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Lewell
D000318:Adrenergic beta-Agonists / Q000737:chemistry*; D000319:Adrenergic beta-Antagonists / Q000737:chemistry*; D000595:Amino Acid Sequence; D008956:Models, Chemical; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011485:Protein Binding; D011943:Receptors, Adrenergic, beta / Q000737:chemistry*
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta