Cytotoxic proteins.
Cytotoxic proteins, which enter eukaryotic cells and catalytically inactivate protein synthesis, are being increasingly studied using a combination of molecular biology, cell biology and structural approaches. The creation of genetically engineered fusions with alternative cell-binding ligands paves the way for tailor-made, cell-type-specific killing agents.
Department of Biological Sciences, University of Warwick, Coventry, UK.
L M
LM
Roberts
J M
JM
Lord
D001426:Bacterial Proteins / Q000378:metabolism / Q000633:toxicity*; D002470:Cell Survival / Q000187:drug effects; D003603:Cytotoxins / Q000378:metabolism / Q000633:toxicity*; D010940:Plant Proteins / Q000378:metabolism / Q000633:toxicity*; D011993:Recombinant Fusion Proteins / Q000378:metabolism / Q000633:toxicity; D013329:Structure-Activity Relationship
D001426:Bacterial Proteins; D003603:Cytotoxins; D010940:Plant Proteins; D011993:Recombinant Fusion Proteins