Proline-specific aminopeptidases: potential role in bradykinin degradation.
The N-terminus of bradykinin is shown to be sequentially degraded by the human proline-specific aminopeptidases aminopeptidase P (EC 3.4.11.9) and dipeptidyl peptidase IV (EC 3.4.14.5). Additional evidence is provided for the hypothesis that these proline-specific aminopeptidases play an essential role in the degradation of peptides containing an N-terminal Xaa-Pro sequence.
Laboratory of Medical Biochemistry, University of Antwerp, Wilrijk, Belgium.
G
G
Vanhoof
I
I
de Meester
D
D
Hendriks
F
F
Goossens
M
M
van Sande
S
S
Scharpé
A
A
Yaron
D000626:Aminopeptidases / Q000378:metabolism*; D001792:Blood Platelets / Q000201:enzymology; D001920:Bradykinin / Q000031:analogs & derivatives* / Q000378:metabolism*; D018819:Dipeptidyl Peptidase 4; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000378:metabolism*; D006801:Humans; D007700:Kinetics
D000626:Aminopeptidases; C022450:prolyl aminopeptidase; C022750:X-Pro aminopeptidase; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D018819:Dipeptidyl Peptidase 4; D001920:Bradykinin