Combined effect of vanadium and zinc on certain selected haematological indices in rats.
1. Two-month-old Wistar rats of both sexes received, as sole drinking liquid, an aqueous solution of ammonium metavanadate (AMV) and zinc chloride (ZC) at concentrations of 0.30 mg V/cm3 and 0.12 mg Zn/cm3 respectively, for a period of 4 weeks. 2. The reference groups received for drinking at this time: water, AMV or ZC solutions at the same concentration. 3. In all groups of animals there was a statistically significant decrease in the uptake of food, AMV or ZC, as well AMV-ZC solutions, as compared with the food and water taken up by the control group. 4. In the group of animals receiving AMV or AMV-ZC solution for drinking the body weight increment diminished significantly. 5. In the animals drinking the AMV-ZC solution a statistically significant decrease in the erythrocyte count and haemoglobin level in the peripheral blood were recorded, similar to the groups drinking AMV or ZC solution. 6. In rats drinking aqueous AMV or ZC solutions and in females receiving AMV-ZC solution the percentage of reticulocytes and polychromatophilic erythrocytes increased, moreover, in the peripheral blood. It was not, however, associated with marked percentage changes in the composition of the bone marrow cells.
Department of Cell Biology, Maria Curie-Skłodowska University, Lublin, Poland.
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Zaporowska
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Wasilewski
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002712:Chlorides / Q000633:toxicity*; D004347:Drug Interactions; D004435:Eating / Q000187:drug effects; D004906:Erythrocyte Count / Q000187:drug effects*; D005260:Female; D006454:Hemoglobins / Q000032:analysis*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012156:Reticulocytes / Q000187:drug effects*; D014638:Vanadates / Q000633:toxicity*; D015032:Zinc / Q000633:toxicity*; D017967:Zinc Compounds
D002712:Chlorides; D006454:Hemoglobins; D017967:Zinc Compounds; D014638:Vanadates; C016837:zinc chloride; D015032:Zinc