Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes.
Insulin-dependent diabetes is characterised by autoantibodies to several pancreatic-islet-cell antigens, including glutamate decarboxylase. We measured the proliferative responses to this antigen of peripheral-blood mononuclear cells from patients with newly diagnosed insulin-dependent diabetes, relatives of diabetic patients, and healthy controls. The likelihood of a positive response was substantially greater among the diabetic patients and relatives positive for islet-cell autoantibodies (ICA) than among subjects at low risk of diabetes (controls and ICA-negative relatives). Glutamate decarboxylase may have a pathogenetic role in insulin-dependent diabetes.
Atkinson
M A
MA
Department of Pathology, University of Florida, Gainesville.
Kaufman
D L
DL
Campbell
L
L
Gibbs
K A
KA
Shah
S C
SC
Bu
D F
DF
Erlander
M G
MG
Tobin
A J
AJ
Maclaren
N K
NK
D001323:Autoantibodies / Q000276:immunology; D003470:Culture Media; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000276:immunology*; D005968:Glutamate Decarboxylase / Q000494:pharmacology*; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000276:immunology; D008213:Lymphocyte Activation
D001323:Autoantibodies; D003470:Culture Media; D005968:Glutamate Decarboxylase