A novel method of induced renal hypothermia.
When the kidney is removed from cold storage for implantation into the recipient it gradually rewarms (second warm ischaemic time) and a prolonged second warm ischaemic time is a risk factor for delayed graft function. A cooling jacket has been designed to prevent this rewarming during transplantation. This study evaluates the efficacy of this device. Surface and core temperatures of less than 15 degrees Centigrade were maintained for 120 minutes. Renal function was significantly better in cooled than in uncooled kidneys in a single kidney canine model. Induced renal hypothermia, using a device such as this, should be a routine manoeuvre in renal transplantation.
Department of Surgery, Beaumont Hospital, Dublin, Ireland.
T A
TA
Creagh
F
F
McLoughlin
P J
PJ
Broe
P A
PA
McLean
D M
DM
Murphy
D J
DJ
Bouchier-Hayes
D000818:Animals; D003080:Cold Temperature; D003404:Creatinine / Q000097:blood; D004285:Dogs; D005919:Glomerular Filtration Rate; D007668:Kidney / Q000473:pathology / Q000502:physiology; D016030:Kidney Transplantation; D009926:Organ Preservation / Q000295:instrumentation / Q000379:methods*; D005723:gamma-Glutamyltransferase / Q000652:urine
D003404:Creatinine; D005723:gamma-Glutamyltransferase