Neuroendocrine effects of ipsapirone on the hypothalamic-pituitary adrenal axis: CRF, ACTH and cortisol in healthy volunteers.
The neuroendocrine effects (changes in plasma CRF, ACTH and cortisol) of single and multiple (t.d.s. for 2 days) doses of ipsapirone (BAY Q 7821) 5 and 10 mg have been investigated in 6 healthy male volunteers. The study followed a balanced complete block, placebo-controlled and double blind design with two baseline phases (pre and post-treatment). Volunteers were investigated on identical days during 5 successive weeks. The results do not show a specific effect of ipsapirone on the hypothalamic-pituitary-adrenal axis when doses in the range of 5-30 mg per day were given.
Beneke
M
M
Troponwerke, Cologne, FRG.
Wingender
W
W
Horstmann
R
R
Konrad-Dalhoff
I
I
Weber
H
H
Kuhlmann
J
J
Schmidt
B H
BH
D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000187:drug effects; D000328:Adult; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D003346:Corticotropin-Releasing Hormone / Q000097:blood / Q000187:drug effects; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D008297:Male; D010913:Pituitary-Adrenal System / Q000187:drug effects*; D011743:Pyrimidines / Q000494:pharmacology*
D014151:Anti-Anxiety Agents; D011743:Pyrimidines; C043077:ipsapirone; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone