Synthesis and biological activity of some new 2-chlorophenothiazine derivatives.
10-(Hetero/arylthio)acetyl-2-chlorophenothiazines II have been synthesized via interaction of 10-chloroacetyl-2-chlorophenothiazine I with heterocyclic and/or aromatic potassium mercaptide in ethanol. Oxidation of II using H2O2/CH3COOH mixture was studied. Structures of the products were verified by elemental and spectral analyses. Some compounds were screened in vitro for their antibacterial activities.
el-Ezbawy
S R
SR
Department of Chemistry, Faculty of Science, Assiut University, Egypt.
Alshaikh
M A
MA
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis; D001419:Bacteria / Q000187:drug effects; D001709:Biotechnology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010640:Phenothiazines / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D010640:Phenothiazines