Effects of X-irradiation and adriamycin on quiescent and proliferating cells of the seminal vesicle in the castrated mouse.
The sensitivity of resting and proliferating cells of the seminal vesicle to X-irradiation and adriamycin has been investigated. Stimulation with testosterone propionate (250 micrograms/day) was started 11 days after castration in BALB/c mice. X-rays (2.5-7.5 Gy total body irradiation) and intraperitoneal injections of adriamycin (4-16 mg/kg body weight) were administered at various times before or after induction of proliferation by testosterone injection. The DNA contents and the weights of the seminal vesicles were determined at 4 days after the start of stimulation. A Do for X-rays of about 10 Gy was found for the seminal vesicle epithelium. For both X-irradiation and adriamycin no significant differences in sensitivity were observed between quiescent (Go) and proliferating (G1; S) seminal vesicle cells.
van der Meer
Y
Y
Department of Cell Biology, Medical School, State University of Utrecht, The Netherlands.
Roepers-Gajadien
H L
HL
Davids
J A
JA
Huiskamp
R
R
Bootsma
A L
AL
de Rooij
D G
DG
D000818:Animals; D002369:Castration; D002453:Cell Cycle / Q000528:radiation effects; D004247:DNA / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D004317:Doxorubicin / Q000494:pharmacology*; D004848:Epithelium / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008938:Mitosis / Q000187:drug effects / Q000528:radiation effects; D009929:Organ Size / Q000187:drug effects / Q000528:radiation effects; D012669:Seminal Vesicles / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects*; D013739:Testosterone / Q000008:administration & dosage
D013739:Testosterone; D004317:Doxorubicin; D004247:DNA