Study of modulatory effects of Olimunostim on cellular immunity in healthy humans.
To objectivize potential modulatory effects of polybacterial lysate Olimunostim on cellular immunity, the T-lymphocyte subpopulations and lymphocyte reactivity to mitogens were followed up in 10 healthy volunteers subjected to Olimunostim application and parallelly in 6 healthy individuals receiving placebo. The preparation, which was applied perorally in seven consecutive daily doses, had no effects on T-lymphocytes and their subpopulations and exerted only a limited influence on lymphocyte reactivity to mitogens. Both the moderate suppression of proliferative response to Con A and PWM, observed after the application of the three doses of Olimunostim, and the insignificantly enhanced response to PHA and Con A, revealed shortly after the last dose was given, were only of transient character and in comparison with the control group were not proved to be statistically significant. To explain the discordance of these results with the recently reported modulatory effects of Olimunostim on murine lymphocytes it is suggested, that the performed tests using the peripheral blood lymphocytes cannot mirror the processes developing in the diseased tissues. With respect to this presumption and also to the observations of enhanced immunomodulatory effect of Olimunostim on terrain altered by infection, it is proposed to investigate cellular immune parameters in specific disease sites of Olimunostim treated patients suffering from recurrent infections.
Institute of Immunology, Medical Faculty, Palacký University, Olomouc, Czechoslovakia.
M
M
Petrek
E
E
Weigl
J
J
Bystron
D
D
Tomanová
A
A
Spidlová
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000328:Adult; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007711:Klebsiella pneumoniae / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D010919:Placebos; D011425:Propionibacterium acnes / Q000276:immunology; D012016:Reference Values; D013211:Staphylococcus aureus / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D000276:Adjuvants, Immunologic; D010919:Placebos