Genetic analysis of the linkage between chromosome 11q and atopy.
Previous work has suggested that there is a genetic predisposition for the development of both asthma and atopy. A recent study has also shown that there is a striking link between chromosome 11q and the IgE response underlying asthma and rhinitis. To further assess the linkage between chromosome 11q and atopy, we have studied nine families of two and, in many instances, three generations with the index case having asthma and/or atopy. Using two restriction fragment length polymorphism probes associated with the regions 11q12-q13.2, namely PYGM and INT2, we have been unable to confirm a significant link between this region of chromosome 11q and atopy as defined by a positive skin-prick test and/or a raised specific IgE and/or a raised total IgE.
Department of Allergy and Allied Respiratory Disorders, UMDS, Guy's Hospital, London, U.K.
P
P
Lympany
K I
KI
Welsh
G M
GM
Cochrane
D M
DM
Kemeny
T H
TH
Lee
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D002880:Chromosomes, Human, Pair 11; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D015335:Molecular Probes; D012150:Polymorphism, Restriction Fragment Length
D015335:Molecular Probes