Anthralin is a potent inhibitor of pityrosporum orbiculare/ovale in vitro.
Two strains of Pityrosporum orbiculare/ovale were grown in a liquid medium and exposed to different concentrations of the imidazoles ketoconazole and clotrimazole as well as anthralin, liquor carbonis detergens and salicylic acid. With regard to growth inhibition of yeast cells, the efficacies of anthralin and the imidazoles were similar, a half-maximal inhibition being achieved with an anthralin concentration of 7 mg/l. Liquor carbonis detergens and salicylic acid also inhibited growth of Pityrosporum orbiculare/ovale, but only at much higher concentrations. The response to salicylic acid was mainly due to its acid pH.
Department of Dermatology, University of Cologne, Germany.
T
T
Bunse
G
G
Mahrle
D000875:Anthralin / Q000494:pharmacology*; D003022:Clotrimazole / Q000494:pharmacology*; D003470:Culture Media; D006131:Growth Inhibitors / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D008290:Malassezia / Q000187:drug effects* / Q000254:growth & development
D003470:Culture Media; D006131:Growth Inhibitors; D007093:Imidazoles; D003022:Clotrimazole; D000875:Anthralin