Role of central ATP-sensitive potassium channels in the hyperthermic effect of morphine in mice.
Morphine (10 mg/kg, SC) in combination with ICV vehicle induced a significant hyperthermic effect at 120 min (peak time) after injection compared to ICV vehicle plus SC saline (control group). Glibenclamide (50 micrograms, ICV), a selective adenosine triphosphate-sensitive potassium (KATP) channel blocker, in combination with SC saline hardly affected the rectal temperature compared to the control group. ICV glibenclamide antagonized the hyperthermia induced by SC morphine in a dose-dependent manner. From these results, we demonstrated that KATP channels play an important role as modulators of the hyperthermic effect of mu agonists.
Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
M
M
Narita
T
T
Suzuki
M
M
Misawa
H
H
Nagase
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005334:Fever / Q000139:chemically induced / Q000503:physiopathology*; D005905:Glyburide / Q000008:administration & dosage / Q000494:pharmacology; D007276:Injections, Intraventricular; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D015221:Potassium Channels / Q000502:physiology*
D015221:Potassium Channels; D009020:Morphine; D000255:Adenosine Triphosphate; D005905:Glyburide