[Multiple resistance of eukaryotic cells caused by P-glycoprotein].
Recent data concerning cloning and sequencing of mdr genes involved in multiple drug resistance in higher eukaryotes are reviewed. Structures of ABC-superfamily members, including the mdr products as well as mechanisms of their superproduction at various levels are considered. The possible role of MDR-transporter in normal tissues and various approaches to overcoming the MDR phenotype are discussed. Non-P-glycoprotein mechanisms of drug resistance capable to modify MDR phenotype and applications of mdr in biotechnology are provided.
Nevzgliadova
O V
OV
Shvartsman
P Ia
PIa
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D003001:Cloning, Molecular; D004351:Drug Resistance; D015870:Gene Expression; D008562:Membrane Glycoproteins / Q000235:genetics*; D005810:Multigene Family; D012689:Sequence Homology, Nucleic Acid
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D008562:Membrane Glycoproteins
Mnozhestvennaia ustoĭchivost' eukarioticheskikh kletok, obuslovlennaia P-glikoproteidom.