Structure prediction and modelling.
Protein structure prediction from sequence remains a major goal in molecular biology. The methods described in this review concentrate on deriving structural information through the detection of similarities between a test sequence and a database of known structures. Such methods are often referred to as knowledge-based strategies reflecting the use of a structural database in the analyses. The past year has seen considerable advances in both the development of automated procedures and their application to protein sequences of outstanding biological interest.
University College London, UK.
M B
MB
Swindells
J M
JM
Thornton
D000465:Algorithms; D000595:Amino Acid Sequence; D016208:Databases, Factual; D008958:Models, Molecular; D011487:Protein Conformation