Short echo time proton spectroscopy of human brain using a gradient head coil.
Short echo time, single voxel localized proton spectroscopy was accomplished using a stimulated echo (STEAM) sequence running on a Siemens 1.5-T system with a head coil incorporating the Z and Y gradients. Spectra from the temporal lobe, the cerebellum and mid brain were acquired from a group of normal volunteers using the following parameters: voxel size = 8 ml, TE = 22 msec, 512 signal averages and TR = 1.7 sec. STEAM spectra acquired with the small diameter gradients showed significantly fewer artifacts at short TE, allowing the observation of glutamate/glutamine, GABA, taurine, and inositol in addition to the prominent resonance of choline, creatine/phosphocreatine and N-acetylaspartate (NAA). The levels of chlorine, creatine and NAA were found to be significantly different in the three regions of the brain examined.
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MR Research Center, Cleveland Clinic Foundation, OH 44195.
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D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D001923:Brain Chemistry; D002531:Cerebellum / Q000378:metabolism; D002794:Choline / Q000032:analysis; D003401:Creatine / Q000032:analysis; D005971:Glutamates / Q000032:analysis; D018698:Glutamic Acid; D005973:Glutamine / Q000032:analysis; D006801:Humans; D007294:Inositol / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D008636:Mesencephalon / Q000378:metabolism; D008875:Middle Aged; D010725:Phosphocreatine / Q000032:analysis; D013654:Taurine / Q000032:analysis; D013702:Temporal Lobe / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000032:analysis
D005971:Glutamates; D010725:Phosphocreatine; D005973:Glutamine; D013654:Taurine; D001224:Aspartic Acid; D018698:Glutamic Acid; D007294:Inositol; D005680:gamma-Aminobutyric Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline