The pathobiology of HIV infection.
The follicular dendritic cells (FDCs) of the germinal center are known to absorb antigens in the form of immune complexes and to express them on the cell surface for long periods of time. Here, Cecil Fox and Michele Cottler-Fox propose that, as a result of FDC binding of immune-complexed viruses, lymphoid organs are the major reservoirs of HIV, and that FDCs play a key role in infection of CD4+ T cells.
Fox
C H
CH
Molecular Histology Labs, Gaithersburg, Maryland 20879.
Cottler-Fox
M
M
D000936:Antigen-Antibody Complex / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000382:microbiology*; D003713:Dendritic Cells / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D015483:HIV Antibodies / Q000276:immunology; D015488:HIV Antigens / Q000276:immunology; D015658:HIV Infections / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000098:blood supply / Q000382:microbiology / Q000473:pathology; D008221:Lymphoid Tissue / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D008954:Models, Biological
D000936:Antigen-Antibody Complex; D015483:HIV Antibodies; D015488:HIV Antigens