Rat liver response elicited by long-term cold exposure.
We measured mitochondrial protein mass as well as State 4 and 3 respiratory rates using different substrates in isolated liver mitochondria from 30-day cold-exposed rats. In addition, we measured the respiration under different conditions of stimulation in isolated hepatocytes from long-term cold-exposed rats. The results show that long-term cold exposure elicits a significant increase in hepatic mass and mitochondrial protein mass. No variation was found in oxygen consumption of isolated mitochondria and hepatocytes. On the whole, the results indicate that long-term exposure elicits an increase in hepatic mitochondrial protein mass but not in hepatic oxygen consumption.
Department of General and Environmental Physiology, University of Naples, Italy.
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Liverini
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Iossa
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Barletta
D000222:Adaptation, Physiological; D000818:Animals; D001835:Body Weight; D003080:Cold Temperature; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology; D009929:Organ Size; D010101:Oxygen Consumption; D010766:Phosphorylation; D051381:Rats; D017208:Rats, Wistar; D013385:Succinate Dehydrogenase / Q000378:metabolism
D013385:Succinate Dehydrogenase