Serum laminin in hepatosplenic human schistosomiasis.
Serum laminin level was measured in chronic hepatic schistosomiasis. A significant increase in the mean serum laminin levels was observed in patients with hepatosplenic (HS) schistosomiasis (2.57 +/- 0.83 U/ml), as compared to those in patients with the hepatointestinal (HI) form of the disease (1.38 +/- 0.45-U/ml) and in the control group (1.15 +/- 0.31 U/ml). In the HS patients there was a significant direct relation between serum laminin and percutaneous splenic pulp pressure (r = 0.68). These findings are compatible with an increased production of laminin in hepatosplenic schistosomiasis with may be related to the observed enlarged liver and spleen basement membranes in such disease.
Disciplina de Gastroenterologia Clínica, Escola Paulista de Medicina, São Paulo, Brasil.
E R
ER
Parise
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MM
Leite-Mór
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H
Rosa
D001485:Basement Membrane / Q000378:metabolism / Q000473:pathology; D002908:Chronic Disease; D005355:Fibrosis; D006801:Humans; D006975:Hypertension, Portal / Q000209:etiology; D007797:Laminin / Q000097:blood*; D008103:Liver Cirrhosis / Q000378:metabolism / Q000469:parasitology; D012552:Schistosomiasis / Q000097:blood* / Q000150:complications; D013154:Spleen / Q000378:metabolism / Q000473:pathology
D007797:Laminin