Immunohistological study of skin involvement in Kikuchi's disease.
Five patients with histiocytic necrotizing lymphadenitis (Kikuchi's disease) with erythematous or popular skin lesions were studied. All patients healed naturally within a few months like the patients with no skin involvement. Histological findings for the skin lesions mimicked cutaneous malignant lymphoma. The infiltrated mononuclear cells usually demonstrated positive reactions for Ki-M1p (20-63%), lysozymes (13-54%), MT-1 (18-64%), UCHL-1 (22-39%) and LN2 (17-36%). OPD-4 and L26 positive cells were few in number. These results suggest that the infiltrated cells in a Kikuchi's disease skin lesion are composed of the same components as the affected lesion in the lymph node.
First Department of Pathology, School of Medicine, Fukuoka University, Japan.
Y
Y
Sumiyoshi
M
M
Kikuchi
M
M
Takeshita
S
S
Yoneda
S
S
Kobari
K
K
Ohshima
D000293:Adolescent; D000328:Adult; D015415:Biomarkers; D003937:Diagnosis, Differential; D005260:Female; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D008199:Lymphadenitis / Q000097:blood / Q000175:diagnosis / Q000276:immunology / Q000473:pathology*; D016410:Lymphoma, T-Cell, Cutaneous / Q000175:diagnosis; D008297:Male; D009000:Monocytes / Q000473:pathology; D012867:Skin / Q000276:immunology / Q000473:pathology*; D012871:Skin Diseases / Q000097:blood / Q000175:diagnosis / Q000276:immunology / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology
D015415:Biomarkers