Mls: a link between immunology and retrovirology.
The nature of the mysterious minor lymphocyte stimulating (Mls) antigens has recently been clarified. These molecules which were key elements for our current understanding of immune tolerance, have a strong influence on the mouse immune system and are encoded by the open reading frame (orf) of endogenous and exogenous mouse mammary tumor viruses (MMTV's). The knowledge that these antigens are encoded by cancerogenic retroviruses opens an interdisciplinary approach for understanding the mechanisms of immune responses and immune tolerance, retroviral carcinogenesis, and retroviral strategies for infection.
Acha-Orbea
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Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges, Switzerland.
Held
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Scarpellino
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Shakhov
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D000595:Amino Acid Sequence; D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics / Q000276:immunology*; D016747:Minor Lymphocyte Stimulatory Antigens / Q000235:genetics / Q000276:immunology*; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D011533:Proviruses / Q000235:genetics; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000956:Antigens, Viral; D016747:Minor Lymphocyte Stimulatory Antigens; D016693:Receptors, Antigen, T-Cell, alpha-beta