Structure prediction and modelling.
Protein structure prediction from sequence remains a major goal in molecular biology. The methods described in this review concentrate on deriving structural information through the detection of similarities between a test sequence and a database of known structures. Such methods are often referred to as knowledge-based strategies reflecting the use of a structural database in the analyses. The past year has seen considerable advances in both the development of automated procedures and their application to protein sequences of outstanding biological interest.
Swindells
M B
MB
University College London, UK.
Thornton
J M
JM
D000465:Algorithms; D000595:Amino Acid Sequence; D016208:Databases, Factual; D008958:Models, Molecular; D011487:Protein Conformation