Chronic metoclopramide treatment stimulates T lymphocyte proliferation in the spleen but not in the thymus.
The effect of chronic metoclopramide administration (for 10 days at a daily dose of 5 mg/kg body weight subcutaneously) on cell proliferation in spleen and in thymus was investigated. Cell proliferation was evaluated by the stathmokinetic method with the use of vincristine. It was found that metoclopramide administration results in a statistically significant increase in the value of the mean mitotic activity rate index (MMAR) of splenocytes in the areas around arteries. At the same time no statistically significant changes were demonstrated in the MMAR index values obtained for splenocytes present in the germinal centers of the spleen. No significant changes in the MMAR index could also be found for thymocytes.
Department of Experimental Endocrinology and Hormone Diagnostics, Institute of Endocrinology, Medical Academy in Lódź.
K
K
Winczyk
G
G
Zerek-Mełeń
M
M
Pawlikowski
D000818:Animals; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D008938:Mitosis / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects*; D013601:T-Lymphocytes / Q000187:drug effects*; D013950:Thymus Gland / Q000033:anatomy & histology / Q000187:drug effects*
D008787:Metoclopramide