[Changes in the renin-angiotensin system and the effectiveness of the treatment of hypertension with calcium antagonists, beta-adrenoblockers and diuretics].
Renin response to nifedipine, verapamil, propranolol and hypothiazide was studied in 133 patients with Stage II hypertensive disease. The common mechanism of action in all these drugs was an increase in baseline plasma renin activity (PRA). In patients with a baseline high RPA, propranolol and nifedipine lowered it, whereas verapamil and hypothiazide unchanged it. Group analysis indicated that enhanced PRA during therapy was unassociated with diminished antihypertensive effects of an agent as compared with patients in whom RPA showed no increase. Propranolol was more effective in patients with high PRA than the other agents. The best nifedipine tolerance was recorded in patients with lower PRA.
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Svishchenko
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004232:Diuretics / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008875:Middle Aged; D012084:Renin-Angiotensin System / Q000187:drug effects*
D000319:Adrenergic beta-Antagonists; D002121:Calcium Channel Blockers; D004232:Diuretics
Dinamika renin-angiotenzinovoĭ sistemy i éffektivnost' lecheniia bol'nykh gipertonicheskoĭ bolezn'iu antagonistami kal'tsiia, beta-adrenoblokatorami i diuretikami.