Renin gene restriction fragment length polymorphisms in a Japanese family with a high incidence of essential hypertension.
1. Human renin gene restriction fragment length polymorphisms (RFLP) were compared in a Japanese family which has a high incidence of essential hypertension. 2. RFLP of human renin gene were observed in three restriction enzymes, Mbo I, Bgl I and Hind III; 1.4 kb and 1.0 kb [Mbo I], 5.0 kb and 9.0 kb [Bgl I] and 9.0 and 6.2 kb [Hind III]. 3. Plasma renin activity was not associated with blood pressure. 4. Renin gene RFLP were not cosegregated with essential hypertension in this Japanese family.
Okura
T
T
2nd Department of Internal Medicine, Ehime University School of Medicine, Japan.
Kitami
Y
Y
Wakamiya
R
R
Iwata
T
T
Hiwada
K
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015139:Blotting, Southern; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes; D005819:Genetic Markers; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000235:genetics*; D007564:Japan; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D012083:Renin / Q000097:blood / Q000235:genetics*
D005819:Genetic Markers; D004247:DNA; D004262:DNA Restriction Enzymes; D012083:Renin