The effect of brassica vegetable consumption on caffeine metabolism in humans.
Ten healthy volunteers were used in two studies investigating the effect of short-term Brassica consumption on caffeine metabolism. In the first study volunteers were given three Brassica-containing meals, the last one 3 h prior to caffeine administration. In the second study volunteers were given two Brassica-containing meals and then fasted overnight before caffeine administration. In both studies the mean plasma half-life of caffeine was reduced by approximately 20% following a Brassica diet, suggesting that Brassica vegetables stimulate caffeine metabolism. When caffeine was given 3 h after the last meal, plasma caffeine concentrations over 6 h, were increased by up to 27% on the Brassica diet compared to controls. This may be due to a transient increased permeability of the intestine to caffeine, immediately following Brassica consumption. This effect was not seen in the second study where there was a 12-h period between the last meal and caffeine administration. There was large interindividual variation in the effect of the Brassica diet on caffeine metabolism.
McDanell
R E
RE
Department of Clinical Pharmacology, University College London, Rayne Institute, UK.
Henderson
L A
LA
Russell
K
K
McLean
A E
AE
D000284:Administration, Oral; D000328:Adult; D001937:Brassica; D002110:Caffeine / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics; D004032:Diet; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged
D002110:Caffeine