Recombinant inbred mouse strains: models for disease study.
Recombinant inbred (RI) strains of mice and the closely related recombinant congenic strains offer considerable promise for identifying and characterizing genes causally associated with many different diseases. Loci associated with diseases such as heart disease, autoimmune disease and leukemia have already been identified through the use of these unique strains.
Mammalian Genetics Laboratory, NCI-Frederick Cancer Research and Development Center, MD 21702.
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MJ
Justice
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Jenkins
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Copeland
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D011995:Recombination, Genetic