Neutrophil adhesion: a point for therapeutic intervention?
It has become increasingly clear over the last 20 years that the potential exists to modulate inflammatory responses with compounds that interfere with intercellular adhesion. This review highlights the adhesion interactions that occur during neutrophil extravasation and indicates some of the possible ways of disrupting these interactions.
Inflammation Biology Group, Celltech Research Ltd, Slough, Berkshire, UK.
M K
MK
Robinson
P E
PE
Stephens
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000502:physiology*; D015195:Drug Design; D016166:Free Radical Scavengers; D006801:Humans; D007249:Inflammation / Q000503:physiopathology* / Q000628:therapy*; D016023:Integrins / Q000502:physiology*; D009504:Neutrophils / Q000502:physiology*; D011480:Protease Inhibitors / Q000627:therapeutic use; D013481:Superoxides / Q000097:blood
D000911:Antibodies, Monoclonal; D015815:Cell Adhesion Molecules; D016166:Free Radical Scavengers; D016023:Integrins; D011480:Protease Inhibitors; D013481:Superoxides