Malignant tumours after renal transplantation.
The incidence of malignant tumours in 570 patients with kidney transplants was examined. It was found to be 20-30 times higher than in the average (normal) population. In accordance with the literature, mainly skin cancers were observed, but at variance with these data, the number of lymphoreticular malignancies was small. On the basis of their study, the authors emphasize the oncogenetic effect of immunosuppression. By comparing the conventional (AZA+PRED) and Cyclosporine (CYA+PRED) treatments, they point out that this risk should be taken into consideration even in Cyclosporine therapy which has otherwise a much more favourable effect.
1st Department of Surgery, Semmelweis University Medical School, Budapest, Hungary.
A
A
Tóth
F
F
Alföldy
J
J
Járay
M
M
Hidvégi
F
F
Perner
D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D016030:Kidney Transplantation / Q000009:adverse effects*; D009369:Neoplasms / Q000209:etiology* / Q000276:immunology