Pharmacokinetics of two oral liquid formulations of oxatomide in children.
A study on the pharmacokinetics of two suspensions of oxatomide at the concentrations of 25 and 2.5 mg/ml was carried out on 12 children (7M, 5F) with a mean age of 9 years and weight of 29 kg. The plasmatic concentration peak, the time to reach the peak and the area under the curve displayed no significant differences between the two formulations. The maximum concentrations and the peak time of oxatomide in children are similar to those observed in adults.
Cavagni
G
G
Istituto di Clinica Pediatrica, Università degli Studi di Parma, Italy.
Caffarelli
C
C
Giordano
S
S
Romanini
E
E
Bertolini
P
P
Benvenuti
C
C
D000284:Administration, Oral; D002648:Child; D005260:Female; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D007558:Italy; D008297:Male; D010879:Piperazines / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013535:Suspensions
D006634:Histamine H1 Antagonists; D010879:Piperazines; D013535:Suspensions; C015408:oxatomide