Babesia divergens vaccine.
A vaccine strategy against Babesia divergens bovine babesiosis was successfully developed after perfecting of an efficient in vitro culture. Crude supernatants and purified fractions were able to induce a vaccine protection in gerbils against B. divergens infection. More, supernatants induced an effective vaccine protection in cattle. The role of B. divergens exoantigens of 17, 37, 46, 70 and 90 kDa in the development of the immune response was clearly demonstrated in gerbils, cattle, and man.
Laboratoire de Biologie Cellulaire, Faculté de Pharmacie, Montpellier, France.
A
A
Gorenflot
E
E
Precigout
A
A
Valentin
G
G
Bissuel
B
B
Carcy
P
P
Brasseur
Y
Y
Moreau
J
J
Schrevel
D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology; D001403:Babesia / Q000276:immunology*; D001404:Babesiosis / Q000276:immunology / Q000517:prevention & control*; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000517:prevention & control*; D005849:Gerbillinae; D010274:Parasitology / Q000379:methods; D016052:Protozoan Vaccines; D014611:Vaccination
D000953:Antigens, Protozoan; D016052:Protozoan Vaccines