Diazald, a newly recognized antimicrobial agent and its spectrophotometric determination.
Diazald, a chemical intermediate for the synthesis of biologically active compounds, was found to be a potent in vitro antimicrobial agent against yeasts, yeast-like and filamentous fungi as well as Gram-positive and Gram-negative bacterial strains. Its activity is not inhibited by either para-aminobenzoic acid (PABA) or the nitroso group-specific 2-aminothiazole-methoxyimino acetic acid (ATMAA). This suggests that the molecule as such is responsible for the antimicrobial activity. For its quick measurement a sensitive spectrophotometric method has been developed.
Uri
J V
JV
Department of Microbiology and Immunology, Philadelphia College of Osteopathic Medicine, PA 19131-1696.
Scola
F
F
D010129:4-Aminobenzoic Acid / Q000494:pharmacology; D000085:Acetates / Q000494:pharmacology; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000032:analysis* / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000935:Antifungal Agents / Q000032:analysis / Q000037:antagonists & inhibitors / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009602:Nitrosamines / Q000032:analysis* / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013053:Spectrophotometry; D013844:Thiazoles / Q000494:pharmacology; D014105:Tosyl Compounds / Q000032:analysis* / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D015003:Yeasts / Q000187:drug effects
D000085:Acetates; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D009602:Nitrosamines; D013844:Thiazoles; D014105:Tosyl Compounds; C085977:2-aminothiazole-methoxyimino acetic acid; C056772:diazalo; D010129:4-Aminobenzoic Acid