Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule.
Short antigenic peptides bound in the groove of class I major histocompatibility complex molecules enable T cells to detect intracellular pathogens. It has been assumed that structural features of the class I molecule alone select which peptides are bound. It is now demonstrated that a complex polymorphism in one of the major histocompatibility complex-encoded putative peptide-transporter genes is associated with an altered spectrum of bound peptides.
Powis
S J
SJ
Department of Immunology, Agricultural and Food Research Council Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, UK.
Deverson
E V
EV
Coadwell
W J
WJ
Ciruela
A
A
Huskisson
N S
NS
Smith
H
H
Butcher
G W
GW
Howard
J C
JC
D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D002352:Carrier Proteins / Q000096:biosynthesis / Q000235:genetics*; D002460:Cell Line; D005805:Genes, MHC Class I; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D007700:Kinetics; D016399:Lymphoma, T-Cell; D008285:Major Histocompatibility Complex; D008565:Membrane Proteins / Q000096:biosynthesis / Q000235:genetics*; D026901:Membrane Transport Proteins; D008969:Molecular Sequence Data; D011061:Poly A / Q000235:genetics; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D011487:Protein Conformation; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D012689:Sequence Homology, Nucleic Acid; D014162:Transfection
D002352:Carrier Proteins; D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D012333:RNA, Messenger; C072083:mtp2 protein, rat; D011061:Poly A