Antioxidant activity of flavonoids from Sideritis javalambrensis.
Five flavonoid glycosides, 4'-O-methylisoscutellarein 7-O-[6"'-acetylallopyranosyl(1----2)glucopyranoside], 4'-O-methylisoscutellarein 7-O-allopyranosyl(1----2)glucopyranoside, 3'-hydroxy-4'-O-methylisoscutellarein 7-O-[6"'-acetylallopyranosyl(1----2) glucopyranoside], and hypolaetin-8-glucoside have been isolated from Sideritis javalambrensis aerial parts and identified by standard methods. These glycosides have been tested for their antioxidant properties alongside other 7,8-substituted flavonoids using FeSO4/cysteine-induced microsomal lipid peroxidation. Superoxide scavenging activity was assessed in the nitroblue tetrazolium test. Among this series of flavonoids, hypolaetin-8-glucoside is the most potent inhibitor of nonenzymic lipid peroxidation. The antiperoxidative activity of these flavonoids may be related to their superoxide scavenging ability.
Rios
J L
JL
Departmento de Farmacología, Facultad de Farmacia, Valencia, Spain.
Mañez
S
S
Paya
M
M
Alcaraz
M J
MJ
D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D002240:Carbohydrate Sequence; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D008969:Molecular Sequence Data; D010944:Plants / Q000737:chemistry
D000975:Antioxidants; D005419:Flavonoids