Double fatal inhalation of dichloromethane.
1 Two cases of lethal poisoning following acute inhalation of extremely high concentrations of dichloromethane (DCM) are reported. The concentrations of the solvent found in the blood of the two subjects collected at autopsy and analysed by gas chromatography/mass spectrometry (572 and 601 mg l-1) were compatible with those measured in the air a few hours after the discovery of the bodies (up to 168,000 ppm). 2 Extensive brain and lung oedema and congestion, microhaemorrhagic changes of the stomach and congestion in other organs were observed on macroscopic and microscopic examination of both subjects. In addition, and in both cases, high but not lethal carboxyhaemoglobin (COHb) levels (30%) were found in the blood collected at autopsy. 3 Narcosis and respiratory depression due to the effect of DCM on the central nervous system (CNS) appear to have played a critical role in the death of the two men. However, biotransformation of the solvent to toxic metabolites, including carbon monoxide (via oxidative dehalogenation by the cytochrome P450-dependent mixed function oxidase system) or formaldehyde, formic acid, inorganic chloride and carbon dioxide (via the glutathione-S-transferase pathway) may have also contributed significantly to fatal toxicity.
Institute of Occupational Medicine, University of Padua Medical School, Italy.
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Manno
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Rugge
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Cocheo
D000280:Administration, Inhalation; D001921:Brain / Q000187:drug effects / Q000473:pathology; D002263:Carboxyhemoglobin / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D008752:Methylene Chloride / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D008875:Middle Aged; D009784:Occupational Diseases / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D014018:Tissue Distribution
D008752:Methylene Chloride; D002263:Carboxyhemoglobin