Antineoplastic activity of the combination of 5-fluorouracil and interferon: preclinical and clinical results.
Interferon (IFN) is capable of modulating the cytotoxic effects and clinical activity of the fluorinated pyrimidine, 5-fluorouracil (5-FU). This occurs in the absence of a demonstrable effect on immune function, suggesting that these effects occur at the biochemical level. Pharmacokinetic studies have also demonstrated that IFN can increase serum levels of 5-FU. The relative importance of these effects on enhancement of 5-FU activity remains to be investigated.
Wadler
S
S
Department of Oncology, Montefiore Medical Center, Bronx, NY 10467.
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D004354:Drug Screening Assays, Antitumor; D005472:Fluorouracil / Q000493:pharmacokinetics / Q000627:therapeutic use; D006801:Humans; D007372:Interferons / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology
D007372:Interferons; D005472:Fluorouracil