In vitro mutagenesis defines drug targets in aldolase of Plasmodium falciparum.
Department PRT, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
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D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D015195:Drug Design; D004351:Drug Resistance / Q000235:genetics; D005634:Fructose-Bisphosphate Aldolase / Q000037:antagonists & inhibitors* / Q000235:genetics; D017125:Genes, Protozoan; D016296:Mutagenesis; D010963:Plasmodium falciparum / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D015800:Protozoan Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics; D011817:Rabbits; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000235:genetics
D000962:Antimalarials; D015800:Protozoan Proteins; D011994:Recombinant Proteins; D005634:Fructose-Bisphosphate Aldolase