Immunotoxic effects of MPT-IP containing 60% methylparathion in mice.
The effects of a single large and repeated small doses of MPT-IP (the industrial product used to produce Wofatox EC 50) containing 60% methylparathion, on the humoral and cellular immunoreactivity of CFLP mice were investigated. Administration of a single LD50/2 dose 3 d prior to immunization caused a 40% increase in the number of splenic PFC on the 5th day but no significant increase in serum antibody titre on the 7th day after immunization. Treatment for 4 weeks with an LD50/40 dose resulted in a 100% increase in splenic PFC, also not associated with a change in serum antibody titre. Under the same conditions and LD50/20 dose had no effect on these parameters. Neither the single large nor the repeated small doses had any effect on the intensity or time course of a DTH reaction. The results show that MPT-IP has an immunotoxic potential in mice under certain experimental conditions.
Department of Hygiene and Epidemiology, Albert Szent-Györgyi University Medical School, Szeged, Hungary.
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Siroki
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Tóth
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D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006462:Hemolytic Plaque Technique; D007159:Immunologic Tests; D007928:Lethal Dose 50; D008297:Male; D008743:Methyl Parathion / Q000276:immunology / Q000633:toxicity*; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D012756:Sheep; D013997:Time Factors
D008743:Methyl Parathion