IgG anti-ganglioside antibodies and their subclass distribution in two patients with acute and chronic motor neuropathy.
IgG anti-ganglioside antibodies were found in two patients with motor neuropathy. The first patient had a chronic axonal neuropathy with persistently elevated anti-GM1 antibodies. The second patient had an acute axonal neuropathy with anti-GM1, GD1b and asialoGM1 antibodies. In both, the IgG subclass study showed that the antibodies belonged to the IgG1 subclass. An enzyme-linked immunosorbent assay (ELISA) for light chains revealed anti-ganglioside antibodies of the lambda type.
Garcia Guijo
C
C
Department of Neurology, Hospital La Paz, Madrid, Spain.
Garcia-Merino
A
A
Rubio
G
G
Guerrero
A
A
Cruz Martinez
A
A
Arpa
J
J
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000906:Antibodies / Q000032:analysis* / Q000145:classification; D002855:Chromatography, Thin Layer; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007158:Immunologic Techniques; D008297:Male; D009046:Motor Neurons; D009068:Movement; D009422:Nervous System Diseases / Q000276:immunology*; D009468:Neuromuscular Diseases / Q000276:immunology*; D013194:Staining and Labeling; D014018:Tissue Distribution
D000906:Antibodies; D005732:Gangliosides; D007074:Immunoglobulin G