Absorption kinetics of cyclosporin in the rat.
Cyclosporin was administered (6 mg kg-1, i.v.) over 15 min, or (10 mg kg-1) by gavage, to two groups of 5 rats. Following i.v. infusion, cyclosporin exhibited triphasic behaviour with mean +/- s.e.m. disposition half-lives of 9.0 +/- 1.3 min, 4.0 +/- 0.5 h and 16.0 +/- 1.7 h. Following oral administration, peak blood concentration (Cmax) of 1290 +/- 93 ng mL-1 was reached after 5 h, when cyclosporin absorption essentially ceased. The absolute bioavailability (F) of cyclosporin was 24.0%. Standard laboratory rat chow consisting of 2% corn oil did not appear to alter cyclosporin absorption kinetics.
Department of Pharmacy, University of Manchester, UK.
S
S
Hedayati
A
A
Bernareggi
M
M
Rowland
D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D016572:Cyclosporine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006207:Half-Life; D007262:Infusions, Intravenous; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D016572:Cyclosporine