Immunohistochemical detection of the multi-drug-resistance marker P-glycoprotein in uterine cervical carcinomas and normal cervical tissue.
Uterine cervical carcinomas and normal cervical tissue (controls) were investigated for the presence of the multi-drug-resistance gene product P-glycoprotein by means of immunohistochemistry, with the C219 monoclonal antibody and the streptavidin-biotin-peroxidase technique. Ten of 11 cervical carcinomas, 2 of which were previously treated with chemotherapeutic agents of the multi-drug-resistance group, showed a positive reaction of tumor cells. All normal controls showed a positive reaction of the ectocervical and endocervical epithelial cells. P-glycoprotein seems to be implicated at least in part in resistance to chemotherapy of cervical carcinoma.
University of the Basque Country, Hospital de Cruces, Bilbao, Spain.
J
J
Schneider
T
T
Efferth
J
J
Mattern
F J
FJ
Rodriguez-Escudero
M
M
Volm
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000911:Antibodies, Monoclonal; D000971:Antineoplastic Combined Chemotherapy Protocols; D015415:Biomarkers; D001761:Bleomycin / Q000627:therapeutic use; D002277:Carcinoma / Q000188:drug therapy / Q000276:immunology*; D002584:Cervix Uteri / Q000276:immunology*; D002945:Cisplatin / Q000627:therapeutic use; D004351:Drug Resistance / Q000276:immunology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008562:Membrane Glycoproteins / Q000032:analysis*; D012016:Reference Values; D014018:Tissue Distribution; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000276:immunology*; D014751:Vindesine / Q000627:therapeutic use
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000911:Antibodies, Monoclonal; D015415:Biomarkers; D008562:Membrane Glycoproteins; D001761:Bleomycin; D002945:Cisplatin; D014751:Vindesine