Transformation of microcrystalline hydrocortisone by free and immobilized cells of Arthrobacter simplex.
The transformation of microcrystalline hydrocortisone by free and immobilized cells of Arthrobacter simplex resulted in formation of prednisolone. The effect of medium composition, non-ionogenic surfactants and exogenous electron acceptors on the delta 1-dehydrogenase activity of free and immobilized cells is described.
Vlahov
R
R
Institute of Organic Chemistry, Bulgarian Academy of Sciences, Sofia.
Pramatarova
V
V
Spassov
G
G
Suchodolskaya
G V
GV
Koshcheenko
K A
KA
D001173:Arthrobacter / Q000378:metabolism*; D003470:Culture Media; D006854:Hydrocortisone / Q000378:metabolism*; D007700:Kinetics; D010088:Oxidoreductases / Q000378:metabolism; D011239:Prednisolone / Q000378:metabolism*; D014812:Vitamin K / Q000494:pharmacology
D003470:Culture Media; D014812:Vitamin K; D011239:Prednisolone; D010088:Oxidoreductases; C022656:3-oxosteroid delta(1) dehydrogenase; D006854:Hydrocortisone