Properties of cyclic AMP-dependent inward current in two identified neurons of the snail Lymnaea stagnalis.
1. Intracellular iontophoresis of cyclic AMP induces a slow, inward sodium current in identified neurons B1 and RPD1 of Lymnaea stagnalis, which is TTX-insensitive and voltage independent. 2. High extracellular Ca2+ or Co2+ ions cause a reduction in the amplitude of the current, whereas low Ca2+ enhances it. 3. Agents known to increase intracellular cyclic AMP lead to depolarization and increased activity in B1, but RPD1 is unaffected. 4. The properties of cyclic AMP-stimulated inward current in neurons of L. stagnalis are compared with those of similar currents in other gastropod species.
Department of Physiological Sciences, University of Manchester, U.K.
A M
AM
Brown
C R
CR
McCrohan
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D002118:Calcium / Q000502:physiology*; D000242:Cyclic AMP / Q000502:physiology*; D066298:In Vitro Techniques; D008195:Lymnaea / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D013779:Tetrodotoxin / Q000494:pharmacology
D013779:Tetrodotoxin; D000242:Cyclic AMP; D002118:Calcium