Alpha-mediated vasoconstriction: transmembrane signalling and receptor reclassification.
Apparent differences in the usage of different calcium pools for the processes of excitation-contraction provides support for further sub-classification of the alpha-adrenoceptors in blood vessels. Presently we have addressed this question by assessing the routes of calcium utilization and the involvement of G-proteins in mediating vasoconstriction in situ.
Triggle
C R
CR
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, AB, Canada.
Tabrizchi
R
R
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology; D002772:Cholera Toxin / Q000494:pharmacology; D019204:GTP-Binding Proteins / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D011942:Receptors, Adrenergic, alpha / Q000145:classification / Q000187:drug effects / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*
D000316:Adrenergic alpha-Agonists; D015220:Calcium Channels; D011942:Receptors, Adrenergic, alpha; D002772:Cholera Toxin; D019204:GTP-Binding Proteins