Nonlinkage of 16q markers to familial predisposition to Wilms' tumor.
Wilms' tumor (WT), a childhood cancer of the kidney, occurs in both familial and sporadic forms. Chromosome 11 genes have been implicated in the etiology of WT, and mutations in a gene at chromosomal band 11p13, WT1, have been identified in a few WT cases. However, 11p13 has been excluded as the site of the predisposition mutation segregating in several large WT families, which implies the existence of a non-11p familial predisposition gene. Recently, loss of heterozygosity for 16q markers located between chromosomal bands 16q13 and 16q22 has been reported in approximately 20% of sporadic Wilms' tumors. To determine if this region of 16q harbors the non-11p familial WT gene, a genetic linkage study of five WT families was undertaken. Using multipoint analyses, we ruled out genetic linkage of familial WT predisposition to 16q.
Huff
V
V
Department of Biochemistry and Molecular Biology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Reeve
A E
AE
Leppert
M
M
Strong
L C
LC
Douglass
E C
EC
Geiser
C F
CF
Li
F P
FP
Meadows
A
A
Callen
D F
DF
Lenoir
G
G
D002871:Chromosome Banding; D002885:Chromosomes, Human, Pair 16; D005260:Female; D016162:Genes, Wilms Tumor; D005819:Genetic Markers; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D008126:Lod Score; D008297:Male; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D009396:Wilms Tumor / Q000235:genetics*
D005819:Genetic Markers