Adenovirus vectors for gene expression.
Adenoviruses possess a combination of features that make them highly suitable as vectors for expression of heterologous genes. Non-conditional and non-defective adeno-vectors have been constructed to obtain high level expression of a number of foreign genes and some of them have been shown in animal models to exhibit excellent promise as vaccine candidates.
Wyeth-Ayerst Research, Philadelphia, Pennsylvania.
M V
MV
Chengalvala
M D
MD
Lubeck
B J
BJ
Selling
R J
RJ
Natuk
K H
KH
Hsu
B B
BB
Mason
P K
PK
Chanda
R A
RA
Bhat
B M
BM
Bhat
S
S
Mizutani
D000256:Adenoviridae / Q000235:genetics*; D000818:Animals; D003001:Cloning, Molecular / Q000379:methods; D015870:Gene Expression; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D014614:Vaccines, Synthetic
D014614:Vaccines, Synthetic