Differential effects of vecuronium on diaphragm and geniohyoid muscle in anaesthetized dogs.
We have examined the sensitivity of the geniohyoid, an upper airway dilating muscle, to vecuronium in 12 anaesthetized dogs undergoing mechanical ventilation of the lungs and compared it with that of the diaphragm. Dogs were allocated randomly to two groups: pentobarbitone alone (group 1, n = 7); pentobarbitone combined with 0.2 MAC (0.44%) of enflurane anaesthesia (group 2, n = 5). Supramaximal single twitch stimulations (0.1 Hz) were applied to the phrenic nerves in the upper thorax and the geniohyoid branches of the hypoglossal nerves at the neck. The evoked responses were assessed by the transdiaphragmatic pressure (Pdi) and the isometric force of the geniohyoid muscles (Tgh) until complete recovery of these variables after i.v. administration of vecuronium 0.02 mg kg-1. In both groups, the magnitude of the depression of twitch response was greater and time required to reach control amplitude was longer in the geniohyoid than the diaphragm. The depression of Tgh was significantly greater in group 2 than in group 1, whereas no change was observed in Pdi between the two groups. We conclude that the geniohyoid is more sensitive to vecuronium than the diaphragm and the differential effects of vecuronium are facilitated by a low concentration of enflurane.
Isono
S
S
Department of Anaesthesiology, School of Medicine, Chiba University, Japan.
Kochi
T
T
Ide
T
T
Sugimori
K
K
Mizuguchi
T
T
Nishino
T
T
D000769:Anesthesia, Inhalation; D000818:Animals; D001696:Biomechanical Phenomena; D003964:Diaphragm / Q000187:drug effects; D004285:Dogs; D004737:Enflurane / Q000494:pharmacology; D006928:Hyoid Bone; D007537:Isometric Contraction / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009334:Neck Muscles / Q000187:drug effects*; D010424:Pentobarbital; D011312:Pressure; D011897:Random Allocation; D012121:Respiration, Artificial; D014673:Vecuronium Bromide / Q000494:pharmacology*
D014673:Vecuronium Bromide; D004737:Enflurane; D010424:Pentobarbital