The antibacterial effect of some neuroleptics on strains isolated from patients with meningitis.
Eighty-two strains of bacteria (Neisseria meningitidis, Haemophilus influenzae, Enterobacteriaceae, Streptococcus pneumoniae, group B streptococci and Listeria monocytogenes) were examined for their in vitro susceptibility to eight drugs, seven neuroleptics (perphenazine, fluphenazine, cis(Z)-clopenthixol, haloperidol, clozapine, clebopride and SCH 23390), and the neuroleptically inactive trans(E)-clopenthixol. The phenothiazines and the thioxanthenes were, on the whole, the most active drugs when measured, the IC50(50) for each group of bacteria being 7.4 to 84 mg/l (with the exception of the activity against the enterobacteriaceae). The antibacterial potency of clozapine, which has an atypical neuroleptic profile, was between 50 and 140 mg/l. Haloperidol also showed an antibacterial activity in the concentration range 35-140 mg/l. The selective D1 antagonist, SCH 23390 and the selective D2 antagonist, clebopride, inhibited only few of the bacteria in the concentration range investigated.
Department of Antibiotics, Statens Seruminstitut, Copenhagen, Denmark.
I
I
Mortensen
J E
JE
Kristiansen
A V
AV
Christensen
E F
EF
Hvidberg
D014150:Antipsychotic Agents / Q000494:pharmacology*; D006193:Haemophilus influenzae / Q000187:drug effects*; D006801:Humans; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D009345:Neisseria meningitidis / Q000187:drug effects*
D014150:Antipsychotic Agents