Membrane protein insertion into the endoplasmic reticulum--another channel tunnel?
The synthesis of biological membranes requires the insertion of proteins into a lipid bilayer. The rough endoplasmic reticulum of eukaryotic cells is a principal site of membrane biogenesis. The insertion of proteins into the membrane of the endoplasmic reticulum is mediated by a resident proteinaceous machinery. Over the last five years several different experimental approaches have provided information about the components of the machinery and how it may function.
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European Molecular Biology Laboratory, Heidelberg, Germany.
D000818:Animals; D002451:Cell Compartmentation; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000378:metabolism*; D005656:Fungal Proteins / Q000378:metabolism; D007425:Intracellular Membranes / Q000378:metabolism; D046911:Macromolecular Substances; D008322:Mammals / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism*; D008954:Models, Biological; D015388:Organelles / Q000378:metabolism; D011498:Protein Precursors / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D021382:Protein Sorting Signals / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000378:metabolism
D005656:Fungal Proteins; D046911:Macromolecular Substances; D008565:Membrane Proteins; D011498:Protein Precursors; D021382:Protein Sorting Signals