Amino acid levels in cerebrospinal fluid of rats after administration of pentylenetetrazol.
1. We studied the effect of pentylenetetrazol (PTZ)-induced myoclonic jerks and generalized clonic-tonic convulsions (GC) on the levels of neurotransmitter amino acids in the cisternal CSF of rats. 2. The levels of aspartate, glutamate, glycine, and taurine were elevated in the CSF during myoclonic jerks and more distinctly immediately after GC. 3. During the recovery period of postictal depression seen in EEG (5 min after GC), the CSF levels of transmitter amino acids were lower than in the control group. 4. PTZ-induced irritative activity in the EEG disappeared in 24 hr but the levels of amino acids remained abnormal. 5. Amino acid changes in the CSF following PTZ-induced convulsions might indicate that the release of amino acids into the extracellular space is increased before and during the propagation of PTZ-induced seizure and decreased during postictal depression.
Department of Neurology, University of Kuopio, Finland.
T
T
Halonen
A
A
Pitkänen
J
J
Partanen
J M
JM
Hyttinen
P J
PJ
Riekkinen
D000596:Amino Acids / Q000134:cerebrospinal fluid*; D000818:Animals; D002404:Catheterization; D004569:Electroencephalography / Q000187:drug effects; D004831:Epilepsies, Myoclonic / Q000134:cerebrospinal fluid* / Q000139:chemically induced; D004830:Epilepsy, Tonic-Clonic / Q000134:cerebrospinal fluid* / Q000139:chemically induced; D008297:Male; D018377:Neurotransmitter Agents / Q000134:cerebrospinal fluid; D010433:Pentylenetetrazole / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D018377:Neurotransmitter Agents; D010433:Pentylenetetrazole