Expression of the CD54 (ICAM-1) and CD11a (LFA-1) adhesion molecules in oral mucosal inflammation.
Previous studies of chronic dermatoses have suggested that expression of the CD54 cell surface antigen (intercellular adhesion molecule-1, ICAM-1) by keratinocytes is a feature of chronic inflammation. However, whether such expression is a prerequisite for intraepithelial migration of lymphocytes is unclear. The present study evaluated the expression of CD54 and its ligand, CD11a (lymphocyte function-associated antigen, LFA-1) in oral lesions of lichen planus, recurrent aphthous stomatitis, secondary Sjögren's syndrome and traumatic ulceration using an immunoperoxide technique. In 33 of 56 lesions examined, substantial numbers of CD11a + cells were present within oral mucosal epithelium despite an absence of detectable keratinocyte CD54 antigen expression. Consequently, CD54/CD11a adhesion interactions may not be critical in the initiation of oral mucosal inflammation.
Verdickt
G M
GM
Department of Dentistry, University of Queensland, Brisbane, Australia.
Savage
N W
NW
Dodd
N M
NM
Walsh
L J
LJ
D015703:Antigens, CD / Q000032:analysis*; D015815:Cell Adhesion Molecules / Q000032:analysis*; D003713:Dendritic Cells / Q000276:immunology / Q000473:pathology; D004848:Epithelium / Q000276:immunology / Q000473:pathology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D015603:Keratinocytes / Q000276:immunology / Q000473:pathology; D007801:Langerhans Cells / Q000276:immunology / Q000473:pathology; D008010:Lichen Planus / Q000276:immunology / Q000473:pathology; D016169:Lymphocyte Function-Associated Antigen-1 / Q000032:analysis*; D009059:Mouth Diseases / Q000276:immunology / Q000473:pathology*; D011991:Receptors, Virus / Q000032:analysis*; D012008:Recurrence; D012859:Sjogren's Syndrome / Q000276:immunology / Q000473:pathology; D013281:Stomatitis, Aphthous / Q000276:immunology / Q000473:pathology; D014456:Ulcer / Q000276:immunology / Q000473:pathology
D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D016169:Lymphocyte Function-Associated Antigen-1; D011991:Receptors, Virus; D018799:Intercellular Adhesion Molecule-1