[Progress in oncogene and antioncogene research].
Recent progress in molecular biology of cancer revealed that mutations which potentiate the activities of proto-oncogenes create the oncogenes to force the growth of tumor cells. On the other hand, inactivation of antioncogenes results in the generations of tumor cells. The progression of many tumors to full malignancy requires both types of changes of the tumor cell genome.
Toyoshima
K
K
Dept. of Oncogene Research, Institute for Microbial Diseases, Osaka University, Japan.
Akiyama
T
T
D016147:Genes, Tumor Suppressor / Q000502:physiology*; D011905:Genes, ras; D006579:Heterozygote; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D011518:Proto-Oncogene Proteins; D011519:Proto-Oncogenes / Q000502:physiology*; D018719:Erb-b2 Receptor Tyrosine Kinases
D011518:Proto-Oncogene Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases