Frequencies of X-ray-induced chromosome translocations in human peripheral lymphocytes as detected by in situ hybridization using chromosome-specific DNA libraries.
In situ hybridization with chromosome-specific DNA libraries was used to analyse radiation-induced stable translocations in human peripheral blood lymphocytes. These data were compared with radiation-induced unstable-type aberrations (dicentrics) in the same samples. The results indicate that far more stable aberrations are induced by radiation in comparison to unstable aberrations.
MGC, Department of Radiation Genetics and Chemical Mutagenesis, State University of Leiden, The Netherlands.
A T
AT
Natarajan
R C
RC
Vyas
F
F
Darroudi
S
S
Vermeulen
D005260:Female; D015723:Gene Library; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000528:radiation effects / Q000648:ultrastructure; D009693:Nucleic Acid Hybridization; D014178:Translocation, Genetic; D014965:X-Rays