Similar central actions of intravenous methohexitone suspension and solution in the rabbit.
The central actions of solutions of methohexitone sodium and suspensions of methohexitone given intravenously in equimolar doses have been compared. The administrations induced identical anaesthesia. Because, in general, drugs acting upon the central nervous system are poorly soluble in water, this finding should be useful for routine pharmacological investigations as it avoids the use of organic solvents which may themselves affect the central nervous system.
Institute of Pharmaceutical Technology, University of Vienna, Austria.
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Viernstein
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Stumpf
D000777:Anesthetics; D000818:Animals; D007275:Injections, Intravenous; D008297:Male; D008723:Methohexital / Q000008:administration & dosage; D010316:Particle Size; D011817:Rabbits; D012996:Solutions; D013535:Suspensions
D000777:Anesthetics; D012996:Solutions; D013535:Suspensions; D008723:Methohexital