Effect of retinoic acid on liver transglutaminase activity and carbon tetrachloride-induced liver damage in mice.
Transglutaminase (TGase) activity in the cytosol fraction of the mouse liver increased following intraperitoneal injection of retinoic acid. Retinoic acid inhibited the carbon tetrachloride-induced increase in serum alanine transaminase activity. These findings suggest that TGase is involved in the effect of retinoic acid on carbon tetrachloride-induced liver damage.
Department of Radiopharmacy, Tohoku College of Pharmacy, Sendai, Japan.
H
H
Kohno
Y
Y
Hoshino
S
S
Katoh
Y
Y
Ohkubo
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002251:Carbon Tetrachloride / Q000633:toxicity*; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology*; D002467:Cell Nucleus / Q000201:enzymology; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D015786:Cytochromes b5 / Q000378:metabolism; D003600:Cytosol / Q000201:enzymology; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000473:pathology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011503:Transglutaminases / Q000378:metabolism*; D014212:Tretinoin / Q000494:pharmacology*
D014212:Tretinoin; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D002251:Carbon Tetrachloride; D011503:Transglutaminases; D000410:Alanine Transaminase; D002118:Calcium