[Laser photocoagulation for experimental choroidal neovascularization. 1. Mild dye laser photocoagulation].
The author treated experimentally produced choroidal neovascularization (ChNV) with mild dye laser photocoagulation (PHC). We treated these ChNVs with 590 nm wavelength, 200 microns spot size, 0.2 second duration and 50 mW of power. Eleven eyes of nine rhesus monkeys were used. Then these ChNVs were examined clinically and histopathologically at 24 hours, 2 weeks and a month after therapeutic PHC. Small ChNVs, less than 1/3 disc diameter healed successfully and histopathologically most of them were coagulated and disappeared. A few poorly developed ChNVs remained, but were well enveloped by the proliferating retinal pigment epithelial (RPE) cells. On the other hand, ChNVs of more than 1/3 disc diameter did not respond to weak PHC, grew actively over a month, and were not completely surrounded by proliferating RPE cells. These results suggest that by mild PHC, small ChNVs may be treatable, however, in large ChNVs, mild PHC may rather accelerate their activity.
Department of Ophthalmology, Kansai Medical University, Moriguchi, Japan.
K
K
Yamada
K
K
Takahashi
H
H
Ohkuma
T
T
Itagaki
T
T
Nishimura
K
K
Yamagishi
T
T
Tomoda
M
M
Uyama
D000818:Animals; D002829:Choroid / Q000098:blood supply* / Q000648:ultrastructure; D008028:Light Coagulation / Q000379:methods; D008253:Macaca mulatta; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D009389:Neovascularization, Pathologic / Q000473:pathology / Q000601:surgery*; D010857:Pigment Epithelium of Eye / Q000473:pathology / Q000648:ultrastructure