Relation between 25-hydroxyvitamin D3, apolipoprotein A-I, and high density lipoprotein cholesterol.
In a survey of cardiovascular risk factors in 185 men and 173 women of a Belgian population group, an independent and highly significant positive correlation was found between the serum concentrations of 25-hydroxyvitamin D3 and apolipoprotein A-I (p less than 0.001 in both sexes). 25-Hydroxyvitamin D3 also showed a positive correlation with high density lipoprotein cholesterol levels (p less than 0.05 in men and p less than 0.005 in women). This relation was independent of a possible effect of 25-hydroxyvitamin D3 on serum calcium. Taking the biological variation of 25-hydroxyvitamin D3 levels (+/- 2 SD = 25 ng/ml) into account, these findings could explain variations in the levels of apolipoprotein A-I of 15 mg/100 ml and of high density lipoprotein cholesterol of 4 mg/100 ml.
Department of Developmental Biology, University of Leuven Medical School, Belgium.
J
J
Auwerx
R
R
Bouillon
H
H
Kesteloot
D000328:Adult; D016632:Apolipoprotein A-I / Q000378:metabolism*; D001055:Apolipoproteins B / Q000097:blood; D001827:Body Height; D001835:Body Weight; D002112:Calcifediol / Q000097:blood*; D002118:Calcium / Q000097:blood; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012727:Sex Characteristics; D005723:gamma-Glutamyltransferase / Q000097:blood
D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D002784:Cholesterol; D005723:gamma-Glutamyltransferase; D002112:Calcifediol; D002118:Calcium