Glycogen phosphorylase hyperactive foci of altered hepatocytes in aged rats.
In untreated 12- to 24-month-old rats, the enzyme histochemical pattern of 45 focal hepatic lesions was investigated in serial sections. In addition to previously characterized glycogen storage foci, a new type of enzymatically altered hepatic focus was found. The outstanding feature of this was an increased glycogen phosphorylase activity. The frequent appearance of glycogen phosphorylase hyperactive foci simultaneously exhibiting excessive glycogen storage suggests a close relationship to the well known glycogen storage foci representing an early stage in the sequence of cellular changes which lead to hepatic tumors.
Bayer AG, Institut für Toxikologie IC, Wuppertal, Federal Republic of Germany.
H
H
Enzmann
H
H
Zerban
E
E
Löser
P
P
Bannasch
D000375:Aging / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers; D004790:Enzyme Induction; D006965:Hyperplasia; D008099:Liver / Q000201:enzymology* / Q000473:pathology; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology; D010641:Phenotype; D006005:Phosphorylases / Q000032:analysis*; D011230:Precancerous Conditions / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains
D015415:Biomarkers; D008112:Liver Glycogen; D006005:Phosphorylases