The antineoplastic drugs dose dependently inhibit the healing of subacute gastric ulcer produced by punching in rats.
The aim of present study was to investigate the effects of some antineoplastic drugs on the healing process of subacute gastric ulcer, produced by punching, in rats. We determined the doses which inhibit the healing rate by 50%. Our results confirm the general observation that present applied anticancer drugs cannot distinguish between normal and tumor cell proliferation. The ID50 values of tested drugs strongly correlate with human doses.
Chemical Works of Gedeon Richter Ltd., Pharmacological Research Center, Budapest, Hungary.
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D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach / Q000473:pathology; D013276:Stomach Ulcer / Q000209:etiology / Q000473:pathology*; D013718:Tensile Strength
D000970:Antineoplastic Agents