Alterations in acetyl coenzyme A carboxylase activities in voles and mice treated with monosodium aspartate.
Changes of body weights and hepatic acetyl-CoA carboxylase activities were measured in voles and mice treated with monosodium-L-aspartate (MSA). MSA was administrated subcutaneously to neonates at 4 mg/g. The MSA-treated mice showed remarkable obesity, associated with the increase in the plasma insulin concentrations and acetyl-CoA carboxylase activities. The activity of acetyl-CoA carboxylase of control voles was very low; under half that of mice. In the MSA-treated voles, although the plasma insulin concentrations also increased, acetyl-CoA carboxylase activities were not elevated and signs of obesity were not observed.
Department of Veterinary Biochemistry, Nippon Veterinary and Animal Science University, Tokyo, Japan.
T
T
Arai
M
M
Sasaki
M
M
Shiomi
T
T
Nonaka
K
K
Ochiai
Y
Y
Oki
D000103:Acetyl-CoA Carboxylase / Q000187:drug effects*; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D003411:Arvicolinae / Q000378:metabolism*; D001224:Aspartic Acid / Q000494:pharmacology*; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005260:Female; D007328:Insulin / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000378:metabolism*
D001786:Blood Glucose; D007328:Insulin; D001224:Aspartic Acid; D000103:Acetyl-CoA Carboxylase