Induction of micronucleated reticulocytes by potassium bromate and potassium chromate in CD-1 male mice.
Micronucleus tests of potassium bromate (KBrO3) and potassium chromate (K2CrO4) were conducted with peripheral blood reticulocytes (PB-RETs) of CD-1 male mice dose intraperitoneally. Peripheral blood cells collected from the tail were stained supravitally with acridine orange (AO) using AO-coated glass slides. Both KBrO3 and K2CrO4 induced micronuclei in PB-RETs in the same manner as in polychromatic erythrocytes of bone marrow.
Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan.
T
T
Awogi
K
K
Murata
M
M
Uejima
T
T
Kuwahara
S
S
Asanami
K
K
Shimono
T
T
Morita
D000818:Animals; D001959:Bromates / Q000633:toxicity*; D002840:Chromates / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D015162:Micronucleus Tests / Q000379:methods; D009153:Mutagens / Q000633:toxicity*; D017680:Potassium Compounds; D012156:Reticulocytes / Q000187:drug effects*
D001959:Bromates; D002840:Chromates; D009153:Mutagens; D017680:Potassium Compounds; C019536:potassium bromate; C027373:potassium chromate(VI)