Geographic origin of the Y chromosomes in "old" inbred strains of mice.
Six distinct Y Chromosomes (Chr) were identified among 39 standard inbred strains of mice with five probes that identified Y Chr-specific restriction fragments on Southern blots. Three Y Chr types, distributed among 31 strains, were of Asian Mus musculus origin. The remaining three Y Chr types, distributed among eight strains, were of M. domesticus origin. The Asian source of the M. musculus Y Chr was confirmed by determining the DNA sequence of 221 bp from an open reading frame within the Sry (sex determining region Y) gene (Gubbay et al., Nature 346: 245-250, 1990) in three inbred strains (C57BL/6J, AKR/J, and SWR/J) and comparing the sequence to the homologous sequences derived from wild caught European and Asian M. musculus males. These data indicate that a minimum of six male mice contributed to the formation of the old inbred strains.
Jackson Laboratory, Bar Harbor, Maine 04609.
P K
PK
Tucker
B K
BK
Lee
B L
BL
Lundrigan
E M
EM
Eicher
D000818:Animals; D001208:Asia; D001483:Base Sequence; D004279:DNA, Viral; D005060:Europe; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D015335:Molecular Probes; D008969:Molecular Sequence Data; D009115:Muridae / Q000235:genetics; D016366:Open Reading Frames; D012150:Polymorphism, Restriction Fragment Length; D013045:Species Specificity; D014998:Y Chromosome
D004279:DNA, Viral; D015335:Molecular Probes