Common principles in protein folding and antigen presentation.
The regular recurrence of hydrophobic amino acid residues along a peptide sequence determines the formation of a longitudinal hydrophobic strip when the peptide forms an alpha-helix. An understanding of the ways this may affect both folding of nascent proteins and antigen presentation should facilitate vaccine and therapeutics design.
Lu
S
S
Department of Pharmacology, University of Massachusetts Medical School, Worcester 01655.
Reyes
V E
VE
Torgerson
R R
RR
Lew
R A
RA
Humphreys
R E
RE
D000595:Amino Acid Sequence; D000941:Antigens / Q000276:immunology; D016384:Consensus Sequence; D000939:Epitopes / Q000276:immunology; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D000941:Antigens; D000939:Epitopes; D011506:Proteins