Relationship between cell-cycle state of erythroid progenitors and fetal hemoglobin synthesis.
DNA-synthesis state of circulating burst forming unit-erythroid (BFU-E) was evaluated in patients with sickle cell anemia and correlated with percent of fetal hemoglobin synthesized in the BFU-E-derived cells. Percentage of S-phase BFU-E inversely correlated with percent fetal hemoglobin synthesized in the BFU-E-derived cells (simple linear correlation coefficient, r = -0.8, P = 0.0302; polynomial regression, R = -0.99, P = 0.0002). This observation is of relevance to our understanding of the relationship between the developmental stage of the erythroid progenitors and expression of globin genes.
Isoyama
K
K
University of South Alabama Comprehensive Sickle Cell Center, Mobile.
Baliga
S
S
Shah
A
A
Mankad
V N
VN
D002453:Cell Cycle / Q000502:physiology; D002478:Cells, Cultured; D004247:DNA / Q000235:genetics / Q000378:metabolism; D015672:Erythroid Precursor Cells / Q000166:cytology* / Q000378:metabolism; D005319:Fetal Hemoglobin / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D014316:Tritium; D004247:DNA; D005319:Fetal Hemoglobin; D013936:Thymidine