The effects of phentolamine and nitroglycerin on right-sided hemodynamics in cardiac patients can be explained by a shift of the systemic venous return curve and right-ventricular output curve.
The present study investigated the effects of phentolamine (PH) and nitroglycerin (NG) on the hemodynamics of the right heart in patients with cardiac disease. The patients were divided into a well-functioning left heart group (W group, n = 15) and a poorly-functioning left heart group (P group, n = 15). Right cardiac hemodynamic parameters and plasma noradrenaline (NA) and adrenaline (A) concentrations were measured before and after administering PH (0.1 mg/kg, i.v.) or NG (0.6 mg, sublingual). In a parallel animal study we obtained a systemic venous return curve by measuring mean circulatory pressure (MCP), mean right atrial pressure (RAP) and cardiac output, before and after administering PH (0.1 mg/kg, i.v.) or NG (12.5 micrograms/kg, i.v.) to anesthetized open-chest dogs (n = 14). We used MCP data (W group: 7.5 mmHg, P group: 10 mmHg) obtained in a separate series of human studies in our laboratory. We constructed the venous return curve by connecting the MCP point on abscissa with the cardiac index (CI)-RAP plot obtained in the clinical study. We also constructed the right ventricular output curve by connecting the point of -2 mmHg on the abscissa with the CI-RAP plot. We obtained the following results: (1) PH shifted the CI-RAP plot to the left and upwards, while NG shifted the CI-RAP plot to the left almost horizontally on the CI-RAP plane, where CI was plotted on ordinate and RAP on abscissa. The length [formula: see text] C = control point, PH = point after PH) of the shift of CI-RAP plot due to PH was greater in the P group than in W group, while there was no difference in the length [formula: see text] C = control point, NG = point after NG) of the shift of CI-RAP plot due to NG between P and W groups. (2) Both PH and NG significantly elevated plasma NA and A concentrations in both the W and P groups. In the P group, PH increased the plasma NA concentration significantly more than did NG, but both drugs increased plasma A concentration to a similar extent. (3) Both PH and NG significantly decreased the mean pulmonary arterial pressure with NG doing so significantly more than PH.(ABSTRACT TRUNCATED AT 400 WORDS)
Imai
Y
Y
2nd Department of Internal Medicine, Gifu University School of Medicine, Japan.
Ito
H
H
Minatoguchi
S
S
Asano
K
K
Watanabe
H
H
Iguchi
H
H
Koshiji
M
M
Kakami
M
M
Hirakawa
S
S
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D002302:Cardiac Output / Q000187:drug effects*; D004285:Dogs; D004837:Epinephrine / Q000097:blood; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D005996:Nitroglycerin / Q000494:pharmacology*; D009638:Norepinephrine / Q000097:blood; D010646:Phentolamine / Q000494:pharmacology*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D016278:Ventricular Function, Right / Q000187:drug effects*
D000317:Adrenergic alpha-Antagonists; D011943:Receptors, Adrenergic, beta; D005996:Nitroglycerin; D009638:Norepinephrine; D004837:Epinephrine; D010646:Phentolamine