[Evoked visual responses in schizophrenic patients].
The authors investigated during prolonged ambulatory treatment with the neuroleptic preparation isofloxythepine (IFT) changes of visually induced responses in 24 psychotic patients. The reference group was formed by 10 healthy volunteers examined before and after administration of a single dose of IFT by the oral route. In addition to the visually induced responses the authors investigated also plasma prolactin levels (PRL). It was found that the latency of the P1 peak and amplitude between peaks A1 are in psychotic patients altered, as compared with healthy subjects. The latency of the P1 peak is after a single dose of IFT in healthy subjects longer and the amplitude A1 higher than in the sick group. In healthy subjects after administration of IFT a negative correlation was observed between the amplitude and the basal PRL level. In patients no relationship was found between PRL levels and parameters of the visually induced response.
Psychiatrická klinika LF UK Hradec Králové.
J
J
Libiger
M
M
Kuba
M
M
Zapletálek
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D003988:Dibenzothiepins / Q000627:therapeutic use; D005074:Evoked Potentials, Visual / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*
D014150:Antipsychotic Agents; D003988:Dibenzothiepins; C022110:isofloxythepin; D011388:Prolactin
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