Application of crystallography to the design of antiviral agents.
A historical review of x-ray crystallography introduces basic concepts and describes the potential of this science to the rational design of antiviral agents. Following a brief introduction to the study of antiviral compounds that inhibit early stages of rhino- and enteroviral infections, the impact of structural studies on rational drug design is discussed in relation to known viral structures.
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907.
M G
MG
Rossmann
M A
MA
McKinlay
D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D015195:Drug Design; D012229:Rhinovirus / Q000187:drug effects; D013329:Structure-Activity Relationship
D000998:Antiviral Agents