Meningococcal septicaemia in a C6-deficient patient and effects of plasma transfusion on lipopolysaccharide release.
Patients whose blood is deficient in the terminal component of complement have an increased susceptibility to meningococcal infection. However, mortality from meningococcal infection is lower in these patients than in immunocompetent subjects. We studied a C6-deficient patient with meningococcal sepsis who received fresh frozen plasma (FFP). The patient's initial plasma endotoxin, C6, and terminal-complement-complex concentrations were low, but rose sharply after treatment with FFP. Samples of the patient's serum taken shortly after admission did not cause endotoxin release from Escherichia coli J5 in vitro, but endotoxin-releasing activity was restored in serum samples taken after infusion of FFP. It is possible that C6-deficient patients have reduced mortality from meningococcal infection because their serum cannot cause acute release of endotoxin from the invading organism and extensive tissue damage is thus avoided.
Department of infectious Diseases and Bacteriology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
P J
PJ
Lehner
K A
KA
Davies
M J
MJ
Walport
A P
AP
Cope
R
R
Würzner
A
A
Orren
B P
BP
Morgan
J
J
Cohen
D000328:Adult; D016470:Bacteremia / Q000276:immunology* / Q000401:mortality; D001770:Blood Bactericidal Activity; D016913:Blood Component Transfusion; D003183:Complement C6 / Q000172:deficiency*; D015938:Complement Membrane Attack Complex / Q000276:immunology; D004731:Endotoxins / Q000378:metabolism; D004926:Escherichia coli / Q000378:metabolism; D005260:Female; D006801:Humans; D008070:Lipopolysaccharides / Q000097:blood*; D008585:Meningitis, Meningococcal / Q000276:immunology* / Q000401:mortality; D009345:Neisseria meningitidis / Q000276:immunology*; D010949:Plasma
D003183:Complement C6; D015938:Complement Membrane Attack Complex; D004731:Endotoxins; D008070:Lipopolysaccharides; C044101:endotoxin, Escherichia coli