[Prevention of migraine using bisoprolol. Results of a double-blind study versus metoprolol].
OBJECTIVE
Comparison of bisoprolol, a beta-1 selective beta blocker with no intrinsic sympathomimetic activity (ISA) and metoprolol, which numerous studies have shown to be an effective migraine prophylactic.


METHODS
Multicentric, cross-over study.


METHODS
125 patients suffering at least from 3 attacks of classic or common migraine a month for at least two years.


METHODS
Bisoprolol 5 mg given once a day, or metoprolol 50 mg given twice a day, for two periods of 12 weeks.


RESULTS
125 patients were admitted to the 4-week run-in phase. A comparison of the main target: frequency of migraine attacks was thus carried out in 78 patients (f. = 63, m. = 15). Both substances reduced the average frequency of migraine per 28-day period by about 50%. There was no statistically significant difference between the two beta-blockers (p greater than 0.05).


CONCLUSIONS
The results of the study show that 5 mg of bisoprolol and 100 mg of metoprolol a day have comparable efficacy for migraine prophylaxis, and show comparable tolerability.
Schmerzzentrum Bad Schönborn.
R
R
Wörz
B
B
Reinhardt-Benmalek
M
M
Föh
K H
KH
Grotemeyer
H W
HW
Scharafinski
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D017298:Bisoprolol; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use; D008881:Migraine Disorders / Q000188:drug therapy*; D011412:Propanolamines / Q000009:adverse effects / Q000627:therapeutic use*
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; D008790:Metoprolol; D017298:Bisoprolol
Migräneprophylaxe durch Bisoprolol. Ergebnisse einer Doppelblindstudie versus Metoprolol.