A comparison of ovulation suppression and ovulation stimulation in the treatment of endometriosis-associated infertility.
This study compares ovulation stimulation or suppression with the pregnancy rate among infertile couples with endometriosis. The design is a nonrandomized, prospective, multicentered cohort analytic study. Two hundred and ninety-seven couples with laparoscopy-proven endometriosis were analyzed: 68 received no therapy, 42 received clomiphene and 74 received danazol. Forty patients (22%) conceived and pregnancy rates were similar in each treatment group. The relative likelihood of pregnancy associated with clomiphene was 2.9 (95% confidence limits 1.2-7.1); the relative likelihood of pregnancy with danazol was 1.02 (95% confidence limits 0.5-2.3). This study suggests that pregnancy rates during clomiphene treatment could be superior to expectant therapy, while pregnancy rate after danazol is similar to no treatment.
Department of Obstetrics and Gynecology, University of Saskatchewan, Saskatoon, Canada.
C W
CW
Simpson
P J
PJ
Taylor
J A
JA
Collins
D000328:Adult; D002996:Clomiphene / Q000494:pharmacology / Q000627:therapeutic use*; D015331:Cohort Studies; D003613:Danazol / Q000494:pharmacology / Q000627:therapeutic use*; D004715:Endometriosis / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D010062:Ovulation Induction; D011247:Pregnancy; D016016:Proportional Hazards Models; D011446:Prospective Studies; D014594:Uterine Neoplasms / Q000150:complications* / Q000188:drug therapy
D002996:Clomiphene; D003613:Danazol