The absence of teratogenic effects of some analgesics used in anaesthesia. Additional evidence from a mouse model.
The possibility exists that agents used in anaesthesia may have adverse teratogenic effects on staff, patients, and developing fetuses. It has been shown that a range of neurotropic drugs, when injected into pregnant mice on the 9th day of gestation, produce a characteristic group of central nervous system malformations in their fetuses. We have studied the possible teratogenicity of pethidine, fentanyl, phenoperidine and lignocaine when tested in this way and conclude that they appear to have less effect than other neurotropic drugs previously tested.
Department of Anaesthetics, Royal Infirmary, Edinburgh.
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Martin
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Jurand
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000701:Analgesics, Opioid / Q000633:toxicity*; D000818:Animals; D002490:Central Nervous System / Q000002:abnormalities* / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005283:Fentanyl / Q000633:toxicity; D008012:Lidocaine / Q000633:toxicity*; D008431:Maternal-Fetal Exchange; D008614:Meperidine / Q000633:toxicity; D051379:Mice; D008815:Mice, Inbred Strains; D010638:Phenoperidine / Q000633:toxicity; D011247:Pregnancy
D000701:Analgesics, Opioid; D008012:Lidocaine; D008614:Meperidine; D010638:Phenoperidine; D005283:Fentanyl