The glycoprotein B gene and its syn3 locus of herpes simplex virus type 1 are involved in the synthesis of virus-associated growth factor (HSGF-1).
A putative growth factor (HSGF-1) associated with herpes simplex virus type 1 (HSV-1), which is similar to PRGF associated with pseudorabies virus, and/or HSGF-2 associated with HSV-2, was described. Experiments with four syncytial (syn) and four nonsyncytial (syn+) HSV-1 strains showed that the ability of this virus to produce HSGF-1 in infected cells is associated with the syn+ phenotype. Double infection of cells with syn+ and syn strain resulted either in enhancement or complete inhibition of HSGF-1 production, depending on the chosen pair of syn+ and syn strains. The studies with the recombinants between the syn+ strain KOS and syn strain ANGpath in the gene for glycoprotein B (gB) and syn3 locus revealed that the gB gene and its syn3 locus play a role in the HSGF-1 synthesis.
Department of Microbiology and Virology, Comenius University, Bratislava, Czechoslovakia.
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F
Golais
M
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Kostál
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Csabayová
J
J
Lesko
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral; D006133:Growth Substances / Q000096:biosynthesis*; D000882:Haplorhini; D010641:Phenotype; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D018139:Simplexvirus / Q000235:genetics* / Q000276:immunology / Q000502:physiology; D014759:Viral Envelope Proteins / Q000235:genetics* / Q000378:metabolism
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D006133:Growth Substances; D011993:Recombinant Fusion Proteins; D014759:Viral Envelope Proteins; C044525:glycoprotein B, herpes simplex virus type 2