Life stressors and coping style are associated with immune measures in HIV-1 infection--a preliminary report.
OBJECTIVE
Life stressors and coping style have been associated with alterations in cellular immunity similar to those seen in HIV-1 infection. The interval between infection with HIV-1 and the development of AIDS is lengthy and highly variable. This pilot study investigated whether life stressors and coping style may account for a portion of this variation.


METHODS
A sample of eleven asymptomatic HIV-1 seropositive homosexual male volunteers responding to a local advertisement was assessed on life stressors, coping style and cellular phenotypic and functional immune measures--T4 "helper" cell/T8 "suppressor" cell ratio, T4 cell count, total lymphocyte count, and natural killer cell cytotoxicity.


RESULTS
Significant associations were observed for both major life stressor impact over the previous year and passive coping style use with the total lymphocyte count; higher life stressor impact and passive coping style use were associated with lower total lymphocyte counts. Similarly, a trend in the same direction was found for the relationship of these two measures with the count of T4 cells, which are directly infected and killed by HIV-1.


CONCLUSIONS
It is well documented that decrements in T4 cell and total lymphocyte counts are powerful predictors of subsequent clinical progression to AIDS. These preliminary findings suggest that life stressors and coping style may also be predictors of the development of AIDS.
Goodkin
K
K
Department of Psychiatry, University of Miami School of Medicine, FL 33136.
Fuchs
I
I
Feaster
D
D
Leeka
J
J
Rishel
D D
DD
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000523:psychology; D000223:Adaptation, Psychological; D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D005260:Female; D006679:HIV Seropositivity / Q000276:immunology* / Q000523:psychology; D015497:HIV-1 / Q000276:immunology; D006716:Homosexuality / Q000523:psychology; D006801:Humans; D008016:Life Change Events; D008297:Male; D010865:Pilot Projects; D011379:Prognosis; D013315:Stress, Psychological / Q000276:immunology / Q000523:psychology