[Toxicokinetic exposure tests for chromium].
In cases of occupational exposure to chromium, very often in the organism enters increased quantitatively or six-valent form of metal, possessing high toxicity, cancerogenic and allergenic effect. Concentrations of the element in urine (CrY), erythrocytes (CrE) and nails (CrH) are chosen as suitable tests for evaluation of the exposure. The studies are performed on 151 exposed and controlled persons. The results received are assessed in view of their accuracy and application for biological control. CrY is appropriate test for evaluation of the near in time exposure. CrH detects the cases of occupational CrH--of increased exposure and deficit. On the basis of the proved dependences dose (CrB)--effect (CrY, CrE, CrH) in exposed workers are recommended BMAC (MAC for Cr = 0.02 mg/m3): CrY-2.3 micrograms/l, CrE-3.6 micrograms/l CrH-2.2 micrograms/g.
R
R
Georgieva
Z
Z
Zaprianov
D002857:Chromium / Q000032:analysis / Q000493:pharmacokinetics* / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000737:chemistry; D005260:Female; D006801:Humans; D008297:Male; D009262:Nails / Q000737:chemistry; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis; D012016:Reference Values; D018675:Toxicity Tests
D002857:Chromium
Toksikokinetichni ekspozistionni testove na khrom.