[Interactions between GABAergic and cholinergic mechanisms involved in monocular optokinetic nystagmus in frogs].
The systemic administration of atropine, a muscarinic cholinergic antagonist, was found to suppress the Nasal-Temporal (N-T) component of the frog monocular optokinetic nystagmus (OKN), which had appeared following a prior injection of bicuculline and which does not exist in the normal animal. On the contrary, the administration of a nicotinic cholinergic antagonist (D-TC, alpha-BGT, Hexamethonium) following that of bicuculline has prolonged the duration of the induced N-T component. Thus, ACh was shown to attenuate or to reinforce the GABAergic inhibition of the N-T component through muscarinic receptors or nicotinic receptors respectively. These data point to the existence of strong interactions between these two neurotransmission systems involved in frog monocular OKN.
Laboratoire de Neurophysiologie et Biologie des Comportements, U.P.R. n. 419 du C.N.R.S., Strasbourg.
N
N
Bonaventure
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B
Jardon
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002794:Choline / Q000502:physiology*; D005730:Ganglionic Blockers / Q000494:pharmacology; D017120:Nystagmus, Optokinetic / Q000187:drug effects / Q000502:physiology*; D011893:Rana esculenta; D015349:Vision, Monocular / Q000187:drug effects / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D005730:Ganglionic Blockers; D005680:gamma-Aminobutyric Acid; D001285:Atropine; D002794:Choline
Interactions de mécanismes GABAergiques et cholinergiques impliqués dans le nystagmus optocinétique monoculaire de la grenouille.