Immunomodulation: suppression, enhancement and autoimmunity.
Recent reports highlight new approaches to immunointervention (suppression or enhancement) based on the known roles of lymphocyte populations, cytokines and their receptors, and adhesion molecules in immune responses. Considerable interest over the past year has focused on immunophilins (cyclophilin and the FK506-binding protein) which appear to play key roles in signal transduction within activated T cells and provide a molecular basis for new advances in immunosuppressive drug therapy.
Thomson
A W
AW
Department of Surgery, University of Pittsburgh School of Medicine, Pennsylvania 15213.
D000818:Animals; D015551:Autoimmunity; D016207:Cytokines / Q000627:therapeutic use; D006801:Humans; D007165:Immunosuppression Therapy; D007167:Immunotherapy; D000922:Immunotoxins; D011956:Receptors, Cell Surface / Q000276:immunology
D016207:Cytokines; D000922:Immunotoxins; D011956:Receptors, Cell Surface