MK-801 antagonizes the lethal action of centrally and peripherally administered cypermethrin in mice and rats.
The present study investigated the effect of MK-801, an N-methyl-D-aspartate antagonist, on the convulsant lethal action of cypermethrin administered centrally or peripherally. Cypermethrin produced severe convulsions and death in a dose-dependent manner. MK-801 (0.5, 1 and 2 mg kg-1, intraperitoneally) significantly increased the onset time of convulsions and decreased the mortality in the peripherally treated cypermethrin group. MK-801 (1.0 and 2.0 mg kg-1) attenuated the convulsant action of cypermethrin (50 micrograms, intracerebroventricularly) significantly. Survival rate was also increased significantly. However, MK-801 (0.5 mg kg-1) did not produce any significant protective effect against centrally administered cypermethrin. These results suggest excitatory amino acids to be a target for pyrethroid-induced neurotoxicity.
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Y
Y
Chugh
A
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Sankaranarayanan
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PL
Sharma
D000818:Animals; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D007306:Insecticides / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000506:poisoning; D008297:Male; D051379:Mice; D011041:Poisoning / Q000401:mortality; D011722:Pyrethrins / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000506:poisoning; D051381:Rats; D011919:Rats, Inbred Strains
D007306:Insecticides; D011722:Pyrethrins; C017160:cypermethrin; D016291:Dizocilpine Maleate