[Pharmacologic profile of dithiadenoxide, a potential non-sedating H1-antihistaminic].
Dithiadenoxide, a product of metabolic S-oxidation of the H1-antihistaminic agent dithiaden (bisulepin, Dithiaden), is also an effective histaminic H1-antagonist in pharmacological experiments in in vivo conditions. In contrast to dithiaden, dithiadenoxide exerts a demonstrable inhibitory action as much as the subtoxic or sublethal dosage in experiments in mice and rats. Its acute toxicity in mice and guinea-pigs substantially decreases; acute toxicological findings in rats are not unambiguous. Other experimental findings demonstrate higher selectivity of pharmacological effects of dithiadenoxide.
Výzkumný ústav pro farmacii a biochemii, Praha.
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Blehová
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Metys
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001582:Benzothiepins / Q000494:pharmacology* / Q000633:toxicity; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000494:pharmacology* / Q000633:toxicity; D051379:Mice; D051381:Rats; D012890:Sleep / Q000187:drug effects
D001582:Benzothiepins; D006634:Histamine H1 Antagonists; C100170:dithiadene
Farmakologický profil potenciálního nesedativního H1-antihistaminika dithiadenoxidu.