The intravenous self-administration of antihistamines by rhesus monkeys.
Rhesus monkeys were trained to lever press for infusions of cocaine during daily, 1-h experimental sessions. Following stabilization of the cocaine-maintained baselines, various antihistamines were substituted for cocaine to determine whether they would be self-administered. The results indicated that all monkeys tested self-administered tripelennamine and chlorpheniramine. One monkey out of the four self-administered pyrilamine, but only at a single (300 microgram/kg) high dose. Phenyltoloxamine, cimetidine and hydroxyzine were not self-administered. These results further illuminate differences amongst H1 antagonists in their potential for self-administration and, when examined in context with other reports, suggest that stimulant-like properties may help mediate their reinforcing effects when present.
Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298.
P M
PM
Beardsley
R L
RL
Balster
D000818:Animals; D001559:Benzhydryl Compounds / Q000008:administration & dosage / Q000633:toxicity; D002744:Chlorpheniramine / Q000008:administration & dosage / Q000633:toxicity; D002927:Cimetidine / Q000008:administration & dosage / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D006634:Histamine H1 Antagonists / Q000008:administration & dosage* / Q000633:toxicity; D006919:Hydroxyzine / Q000008:administration & dosage / Q000633:toxicity; D008253:Macaca mulatta; D008297:Male; D009042:Motivation; D011738:Pyrilamine / Q000008:administration & dosage / Q000633:toxicity; D012646:Self Administration; D019966:Substance-Related Disorders / Q000209:etiology*; D014309:Tripelennamine / Q000008:administration & dosage / Q000633:toxicity
D001559:Benzhydryl Compounds; D006634:Histamine H1 Antagonists; D006919:Hydroxyzine; D014309:Tripelennamine; D002744:Chlorpheniramine; D002927:Cimetidine; D011738:Pyrilamine; C008865:phenyltoloxamine