Active and inactive renin in the plasma of the snake Bothrops jararaca.
1. Complementing the work of Gervitz R. K., Hiraichi E., Fichman M. and Lavras A. A. C. Comp. Biochem. Physiol. 86A, 503-507 (1987), conditions have been established for measuring plasma renin activity (PRA) of the venomous snake Bothrops jararaca (Bj). 2. It corresponded to 115.9 +/- 11.5 ng equivalents of angiotensin II (AII) per ml of plasma (N = 13). 3. PRA did not increase when Bj plasma was submitted to acid-cryo-trypsin Bitis arietans venom activation of inactive renin. 4. This may indicate either absence of inactive renin in this plasma or lack of its activation, due to the already demonstrated (Nahas L., Kamiguti A. S., Betti F., Martins I. S. S. and Rodrigues M. I., Comp. Biochem. Physiol. 69A, 739-743, 1981; Prezoto B. C., Hiraichi E., Abdalla F. M. F. and Picarelli Z. P., Comp. Biochem. Physiol. 99C, 135-139, 1991) absence of factor XII.
Serviço de Farmacologia, Instituto Butantan, São Paulo, SP, Brazil.
R K
RK
Gervitz
C M
CM
Brandi
S H
SH
Monteiro
Z P
ZP
Picarelli
D000818:Animals; D001681:Biological Assay; D004789:Enzyme Activation; D004792:Enzyme Precursors / Q000097:blood; D012083:Renin / Q000097:blood*; D012911:Snakes / Q000097:blood*
D004792:Enzyme Precursors; D012083:Renin