Neural tube and other developmental anomalies in the guinea pig following maternal hyperthermia during early neural tube development.
Guinea pigs were exposed to hyperthermia for 1 hr once or twice on day 11, 12, 13, or 14 (E11-E14) of pregnancy. The mean rectal temperatures were elevated by 3.4 degrees C-4.0 degrees C. This treatment resulted in a marked elevation of rates of resorption and developmental defects in embryos examined at day E23. The defects observed were those affecting the neural tube (NTD) (exencephaly, encephaloceles, and microphthalmia), kyphosis/scoliosis, branchial arch defects, and pericardial edema. Embryos with NTD and kyphosis/scoliosis have not been found among newborn guinea pigs to date following maternal heat exposure on days E12-E14. It appears that embryos with these defects are filtered out by resorption or abortion by days E30-E35.
Department of Veterinary Clinical Sciences, University of Sydney, New South Wales, Australia.
J
J
Cawdell-Smith
J
J
Upfold
M
M
Edwards
M
M
Smith
D000022:Abortion, Spontaneous / Q000209:etiology; D000818:Animals; D004195:Disease Models, Animal; D005124:Eye Abnormalities / Q000209:etiology; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005327:Fetal Resorption / Q000209:etiology; D006168:Guinea Pigs / Q000196:embryology*; D006979:Hyperthermia, Induced / Q000009:adverse effects*; D007738:Kyphosis / Q000209:etiology; D009436:Neural Tube Defects / Q000209:etiology*; D011247:Pregnancy; D012600:Scoliosis / Q000209:etiology