T lymphocyte subsets in chronic uremic patients treated with maintenance hemodialysis.
Blood T lymphocyte subsets have been studied using monoclonal antibodies in 10 chronic uremic patients treated with maintenance hemodialysis. Both total T lymphocytes identified by the antibody OKT3, and the helper-inducer T lymphocyte subset identified by the antibody OKT4 were found to be significantly lower than normal. The cytotoxic-suppressor T cell subset was only moderately, even if significantly reduced, so that the T4/T8 ratio in uremic patients was significantly lower than normal. These data provide an additional contribution to the interpretation of immunological and hematological deficiencies observed in chronic uremia.
Morra
L
L
Istituto Scientifico di Medicina Interna (ISMI), University of Genoa, Italy.
Ponassi
G A
GA
Gurreri
G
G
Moccia
F
F
Mela
G S
GS
Bessone
G
G
D000328:Adult; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000276:immunology*; D007962:Leukocytes; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014511:Uremia / Q000276:immunology*