Sulfasalazine induced agranulocytosis treated with granulocyte-macrophage colony stimulating factor.
We report the use of granulocyte-macrophage colony stimulating factor (GM-CSF) in a case of rheumatoid arthritis with sulfasalazine induced agranulocytosis, leading to a rapid bone marrow recovery within 7 days. This case and 2 others reported in the literature emphasize the need for further research into the possible role of GM-CSF in the treatment of drug induced agranulocytosis.
Kuipers
E J
EJ
Department of Internal Medicine, University Hospital, Groningen, The Netherlands.
Vellenga
E
E
de Wolf
J T
JT
Hazenberg
B P
BP
D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001853:Bone Marrow / Q000473:pathology; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D012460:Sulfasalazine / Q000009:adverse effects*
D012460:Sulfasalazine; D016178:Granulocyte-Macrophage Colony-Stimulating Factor