The concept of supersensitivity psychosis.
The hypothesis that chronic neuroleptic treatment may induce relapse in some schizophrenic patients has received considerable attention. This effect, usually called supersensitivity psychosis, has been attributed to neuroleptic-induced changes in mesolimbic or mesocortical dopaminergic receptors. However, research has not established that neuroleptics cause the proposed effect, and considerations of mechanism have not been separated from those of causation. The focus of research in this area should be the establishment or refutation of a causal relationship between chronic neuroleptic use and psychotic relapse.
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore 21228.
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Kirkpatrick
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Buchanan
D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004361:Drug Tolerance; D006801:Humans; D011605:Psychoses, Substance-Induced / Q000209:etiology* / Q000523:psychology; D011954:Receptors, Dopamine / Q000187:drug effects*; D012008:Recurrence; D012559:Schizophrenia / Q000188:drug therapy* / Q000209:etiology; D012565:Schizophrenic Psychology; D013375:Substance Withdrawal Syndrome / Q000209:etiology; D009626:Terminology as Topic
D014150:Antipsychotic Agents; D011954:Receptors, Dopamine