Pipradrol conditioned place preference is blocked by SCH23390.
We investigated the effect of the selective D1 dopamine antagonist, SCH23390, on the establishment of a pipradrol-conditioned place preference (CPP). Among various doses of pipradrol (6.25-75.0 mg/kg, SC), a CPP was established at 25.0 mg/kg. SCH23390 (0.16 mg/kg, IP) blocked the establishment of a CPP by this dose of pipradrol. The results suggest that pipradrol produces a rewarding effect and that this effect may involve activation of D1 dopamine receptors.
Department of Psychology, McGill University, Montreal, Quebec, Canada.
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White
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Hiroi
D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D008297:Male; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors; D012201:Reward
D001552:Benzazepines; D010880:Piperidines; D017447:Receptors, Dopamine D1