Effect of phenoclor DP6 on enzyme-altered foci and lipid peroxidation in livers of aflatoxin B1-initiated rats.
This study investigates the capacity of phenoclor DP6 to promote aflatoxin B1 (AFB1)-induced putative preneoplastic foci in the liver. In male Sprague-Dawley rats pretreated with AFB1 (ip injection of 1 or 2 mg/kg body weight once weekly for 3 consecutive wk) and given a diet containing 50 ppm phenoclor DP6 for 11 days, the number of area of putative liver preneoplastic lesions were increased approximately four-fold as indicated by the number and gamma-glutamyl transpeptidase activity of enzyme-altered foci; this change was also accompanied by an increase in hepatic microsomal lipid peroxidation and a decrease in Se-glutathione peroxidase and superoxide dismutase activities. The results indicate that phenoclor DP6 exerts a promoting effect in AFB1-initiated rats.
Pélissier
M A
MA
C.N.A.M., Laboratoire de Biologie, Paris, France.
Frayssinet
C
C
Boisset
M
M
Albrecht
R
R
D016604:Aflatoxin B1 / Q000633:toxicity*; D000818:Animals; D005979:Glutathione Peroxidase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000201:enzymology / Q000473:pathology*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000201:enzymology / Q000473:pathology; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D011078:Polychlorinated Biphenyls / Q000494:pharmacology* / Q000633:toxicity; D011230:Precancerous Conditions / Q000139:chemically induced* / Q000201:enzymology / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000378:metabolism
C013191:phenoclor; D016604:Aflatoxin B1; D011078:Polychlorinated Biphenyls; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005723:gamma-Glutamyltransferase