[The characteristics of the anxiolytic action of benzodiazepine and non-benzodiazepine tranquilizers in different tests of anxiety].
In experiments on rats the presence or absence was studied of the phenomenon of potentiation of anxiolytic action, estimated by the time of the animal stay in the light part of the chamber in tests of avoidance of "the lighted ground" or "menacing situation" at combined application of the pairs of substances of benzodiasepine and non-benzodiasepine series (elenium, indoter, campiron and campironin). Spectra of their neurochemical activity were determined in experiments on neurones of isolated spinal ganglia of rats with intracellular biopotentials records. It has been established that GABA-potentiating action of indoter and elenium, dopamine-negative action of campiron and campironin are significant in their anxiolytic action in the states of alarm of aversive genesis of different modalities. Serotoninmimetic effect of non-diasepine tranquilizers is of functional significance in the test of avoidance of "the lighted ground", but not of the "menacing situation". It is suggested that differences of neurochemical mechanisms of anxiolytic action of the tested tranquilizers testify to different neurochemical profiles of the neuronal "matrices" of the studied states of alarm.
Talalaenko
A N
AN
Abramets
I I
II
Stakhovskiĭ
Iu V
IuV
Shekhovtsov
A A
AA
Shevchenko
S L
SL
Chernikov
A V
AV
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy* / Q000503:physiopathology; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D001569:Benzodiazepines; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005727:Ganglia, Spinal / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D008839:Microelectrodes; D051381:Rats; D013997:Time Factors
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines
Osobennosti anksioliticheskogo deĭstviia benzodiazepinovykh i nebenzodiazepinovykh trankvilizatorov na razlichnykh testakh trevogi.