Alcohol-preferring rats have fewer dopamine D2 receptors in the limbic system.
Dopamine D2 receptors in nucleus accumbens, olfactory tubercle and caudate nucleus of Sardinian ethanol-preferring (SP), and non-preferring (SNP) rats were compared by using [3H]YM-09151-2 binding. SP rats exhibited, in each area, lower density of D2 receptors than SNP and unselected Wistar (UW) rats. The results suggest that reduction in D2 receptors in SP rats may be relevant to their innate preference for alcohol.
Stefanini
E
E
Bernard B. Brodie Department of Neuroscience, University of Cagliari, Italy.
Frau
M
M
Garau
M G
MG
Garau
B
B
Fadda
F
F
Gessa
G L
GL
D000428:Alcohol Drinking / Q000235:genetics*; D000818:Animals; D015536:Down-Regulation; D006801:Humans; D007223:Infant; D008032:Limbic System / Q000378:metabolism*; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics*; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism*
D018377:Neurotransmitter Agents; D011954:Receptors, Dopamine