Antigenized antibodies.
A new process, antigenization of antibodies, consisting of the expression of oligopeptides in the hypervariable loops of an antibody molecule is described. The potential applications of antigenized antibodies are discussed.
Zanetti
M
M
Department of Medicine, University of California, San Diego 92103.
D000818:Animals; D000906:Antibodies / Q000276:immunology*; D000936:Antigen-Antibody Complex; D000941:Antigens / Q000276:immunology*; D001666:Binding Sites, Antibody; D015704:CD4 Antigens / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007147:Immunoglobulin Light Chains / Q000235:genetics; D007135:Immunoglobulin Variable Region / Q000235:genetics / Q000276:immunology; D051379:Mice; D016254:Mutagenesis, Insertional; D013601:T-Lymphocytes / Q000276:immunology
D000906:Antibodies; D000936:Antigen-Antibody Complex; D000941:Antigens; D015704:CD4 Antigens; D000939:Epitopes; D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D007135:Immunoglobulin Variable Region