Expression of the murine Dlx-1 homeobox gene during facial, ocular and limb development.
We have analysed the expression pattern of the mouse homeobox containing gene Dlx-1. This gene harbors a homeodomain related to that found in the Drosophila distal-less (dll) gene. In addition to its expression in the developing forebrain, Dlx-1 is transcribed in several structures containing cells of neural crest origin such as the facial mesenchyme and various elements of the peripheral nervous system. Dlx-1 transcripts are also detected in the differentiating retina and during limb morphogenesis, in the apical ectodermal ridge. The possible involvement of Dlx-1 during facial, ocular and limb development is discussed.
European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany.
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D000818:Animals; D002454:Cell Differentiation; D004475:Ectoderm / Q000166:cytology; D005314:Embryonic and Fetal Development; D005121:Extremities / Q000196:embryology*; D005123:Eye / Q000166:cytology / Q000196:embryology*; D005145:Face / Q000196:embryology*; D015870:Gene Expression / Q000235:genetics*; D005801:Genes, Homeobox / Q000235:genetics*; D051379:Mice; D009420:Nervous System / Q000166:cytology / Q000196:embryology