Experimental autoimmune uveoretinitis: a model system for immunointervention: a review.
Experimental autoimmune uveoretinitis (EAU) is a useful model of human posterior uveitis and as such, permits the analysis of strategies for immuno-intervention. Modulation of the autoimmune response may be attempted at the stages of induction of EAU, during homing of autoreactive lymphocytes to the target organ, the retina, or during the effector stage of the disease. This paper presents a brief overview of current immuno-therapeutic modalities and assesses the usefulness for extrapolation to human disease.
Forrester
J V
JV
Department of Opthalmology, University of Aberdeen, Medical School, Foresterhill, UK.
Liversidge
J
J
Dua
H S
HS
Dick
A
A
Harper
F
F
McMenamin
P G
PG
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D004195:Disease Models, Animal; D006801:Humans; D007167:Immunotherapy; D016201:Receptors, Lymphocyte Homing / Q000276:immunology; D012173:Retinitis / Q000276:immunology / Q000628:therapy*; D015866:Uveitis, Posterior / Q000276:immunology / Q000628:therapy*
D016201:Receptors, Lymphocyte Homing