Effect of cacao husk extract on human immunodeficiency virus infection.
A sodium hydroxide extract from cacao husk inhibited the cytopathic effect of human immunodeficiency virus type 1 (HIV-1) against HTLV-1-transformed T-cell lines MT-2 and MT-4. It also inhibited syncytium formation between HIV-infected and uninfected lymphoblastoid T-cell line, MOLT-4. The anti-HIV activity was concentrated by membrane filter fractionation to a fraction with molecular weight of 100-300 KDa. Anti-HIV activity of the extract was attributable to interference with the virus adsorption, rather than to inhibition of the virus replication after adsorption.
AIDS Research Center, National Institute of Health, Tokyo, Japan.
S
S
Unten
H
H
Ushijima
H
H
Shimizu
H
H
Tsuchie
T
T
Kitamura
N
N
Moritome
H
H
Sakagami
D002099:Cacao; D002460:Cell Line; D002461:Cell Line, Transformed; D005591:Chemical Fractionation; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D015726:Giant Cells / Q000187:drug effects; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013601:T-Lymphocytes / Q000382:microbiology*; D014779:Virus Replication / Q000187:drug effects
D010936:Plant Extracts