Antibody geometry and form: three-dimensional relationships between anti-idiotypic antibodies and external antigens.
Anti-idiotypes have been developed to mimic a wide variety of antigens in studies of antibody-antigen interactions. Molecular, biochemical and structural analysis of antibody-anti-idiotype pairs presents an excellent model for study of complex protein-protein interactions. An understanding of the ways in which anti-idiotypes mimic antigens and the features determining binding characteristics will facilitate rational design of compounds with biological, enzymatic, pharmaceutical and chemical applications.
Williams
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WV
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-4283.
Weiner
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DB
Kieber-Emmons
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Greene
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MI
D000595:Amino Acid Sequence; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000737:chemistry / Q000276:immunology*; D000937:Antigen-Antibody Reactions; D000941:Antigens / Q000737:chemistry / Q000276:immunology*; D001666:Binding Sites, Antibody / Q000276:immunology; D006241:Haptens / Q000276:immunology; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011506:Proteins / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D000941:Antigens; D006241:Haptens; D011506:Proteins