Pipecuronium versus high dose vecuronium. II. A comparison of speed of onset and cumulation during propofol anaesthesia.
The onset time and tendency to cumulation of pipecuronium and high-dose vecuronium were compared during nitrous oxide anaesthesia supplemented with a propofol infusion. Pipecuronium 0.06 mg.kg-1 had a similar duration of action to vecuronium 0.2 mg.kg-1 (49 vs 43). Patients who received vecuronium had a shorter onset time of neuromuscular blockade (p less than 0.01). Neither pipecuronium nor vecuronium showed marked cumulation.
Harrop-Griffiths
W
W
Department of Anaesthesia, St Mary's Hospital, London.
Platt
M
M
Hirsch
N
N
Feldman
S
S
D000328:Adult; D000368:Aged; D015113:Androstane-3,17-diol / Q000031:analogs & derivatives* / Q000494:pharmacology; D000771:Anesthesia, Intravenous; D004334:Drug Administration Schedule; D006801:Humans; D008875:Middle Aged; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology; D009469:Neuromuscular Junction / Q000187:drug effects*; D017300:Pipecuronium; D010879:Piperazines / Q000494:pharmacology*; D015742:Propofol; D013997:Time Factors; D014673:Vecuronium Bromide / Q000008:administration & dosage / Q000494:pharmacology*
D009466:Neuromuscular Blocking Agents; D010879:Piperazines; D017300:Pipecuronium; D015113:Androstane-3,17-diol; D014673:Vecuronium Bromide; D015742:Propofol