The role of dopamine in mood disorders.
The findings on dopamine in mood disorders suggest that decreased dopamine activity is involved in depression, while increased dopamine function contributes to mania. This report reviews the considerable preclinical and clinical evidence supporting this hypothesis, with particular emphasis on specific subtypes of depression. We also discuss the importance of integrating these dopamine findings with dopamine brain circuitry and with other neurotransmitter theories of affective disorders.
Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213.
D J
DJ
Diehl
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S
Gershon
D001714:Bipolar Disorder / Q000188:drug therapy / Q000503:physiopathology*; D001923:Brain Chemistry; D001971:Bromocriptine / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy / Q000503:physiopathology*; D004298:Dopamine / Q000502:physiology*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use; D008297:Male; D018377:Neurotransmitter Agents / Q000502:physiology; D010891:Piribedil / Q000627:therapeutic use
D018377:Neurotransmitter Agents; D001971:Bromocriptine; D010891:Piribedil; D007099:Imipramine; D004298:Dopamine