Characterization of two cDNAs encoding insulin-like growth factor 1 (IGF-1) in the human fetal brain.
Insulin-like growth factor 1 (IGF-1) regulates growth of the brain. In order to characterize the variant IGF-1 present in human fetal brain we have determined the cDNA sequence for human fetal brain IGF-1. Using PCR to amplify cDNA obtained from isolated human fetal brain mRNA, two cDNA sequences encoding precursor proteins which correspond to IGF-1a and IGF-1b were obtained. This is the first characterisation of IGF-1 and its IGF-1a and IGF-1b precursors in the nervous system.
Karolinska Institute's Department of Pathology, Karolinska Hospital, Stockholm, Sweden.
A C
AC
Sandberg-Nordqvist
P A
PA
Ståhlbom
M
M
Lake
V R
VR
Sara
D000595:Amino Acid Sequence; D001483:Base Sequence; D002540:Cerebral Cortex / Q000196:embryology / Q000502:physiology*; D004247:DNA / Q000235:genetics*; D005333:Fetus; D005865:Gestational Age; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D008969:Molecular Sequence Data; D011061:Poly A / Q000235:genetics / Q000302:isolation & purification; D012313:RNA / Q000235:genetics / Q000302:isolation & purification; D012333:RNA, Messenger; D012689:Sequence Homology, Nucleic Acid
D012333:RNA, Messenger; D011061:Poly A; D012313:RNA; D007334:Insulin-Like Growth Factor I; D004247:DNA