[Febrile convulsions: should some drugs be contraindicated?].
Should certain drugs be contraindicated in children who have had febrile seizures or who present a risk of convulsions? There are no publications dealing specifically with this problem. However, many drugs can induce convulsions and may be dangerous if they are associated with another determining factor (e.g. fever). Camphor known to be toxic and its use must be avoided in young children. Other terpenes given to children with colds may be convulsant if they are used for prolonged treatment or associated with other convulsant drugs (sympathomimetics, piperazine derivatives, antihistamines, etc.). On the basis of a retrospective study of 23 cases of febrile convulsion among 343 cases of infantile convulsion reported to the Poison Control Center and the Pharmacovigilance Center of Marseille between 1973 and 1991, we propose that camphor and sympathomimetics be avoided and that potential convulsant drugs and their association be used with caution. A prospective study is underway to determine responsibility of certain drugs in the occurrence of recurrence of febrile convulsions.
Centre de Pharmacovigilance, Hôpital Salvator, Marseille.
M C
MC
Galland
Y
Y
Griguer
S
S
Morange-Sala
M J
MJ
Jean-Pastor
F
F
Rodor
J
J
Jouglard
D000996:Antitussive Agents / Q000009:adverse effects; D002675:Child, Preschool; D000075202:Contraindications; D005260:Female; D006634:Histamine H1 Antagonists / Q000009:adverse effects; D006801:Humans; D007223:Infant; D008297:Male; D004364:Pharmaceutical Preparations; D003294:Seizures, Febrile / Q000139:chemically induced*; D013566:Sympathomimetics / Q000009:adverse effects; D013729:Terpenes / Q000009:adverse effects
D000996:Antitussive Agents; D006634:Histamine H1 Antagonists; D004364:Pharmaceutical Preparations; D013566:Sympathomimetics; D013729:Terpenes
Convulsions fébriles: faut-il contre-indiquer certains médicaments?