The Mouse Genome Project and human genetics. A report from the 5th International Mouse Genome Mapping Workshop, Lunteren, Holland.
Genome-wide mapping efforts are moving toward the establishment of a 1-cM genetic map of the entire mouse genome. The bulk of linkage groups conserved between the mouse and the human genomes has been identified. Microsatellite mapping has had a major impact on the development of genome-wide genetic maps and, in particular, on genome-wide searches for polygenic disease loci. Some substantial regions of the mouse genome have a marker density of 1 cM or less and many of these regions are now physically mapped. Embryonic YAC contigs have been established in some physically mapped regions. A unitary, global mouse mapping database--the Mouse Genome Database--is under development along with associated software tools. Chromosome committees are having a major impact on the establishment and verification of chromosome maps through the preparation of published annual reports.
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Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, London, United Kingdom.
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004274:DNA, Recombinant; D004276:DNA, Satellite / Q000032:analysis; D016208:Databases, Factual; D005819:Genetic Markers; D015698:Genomic Library; D016045:Human Genome Project; D006801:Humans; D008322:Mammals / Q000235:genetics; D051379:Mice / Q000235:genetics*; D012376:Rodent Diseases / Q000235:genetics
D004274:DNA, Recombinant; D004276:DNA, Satellite; D005819:Genetic Markers