In vivo neurotoxin administration alters immune responses in chickens (Gallus domesticus).
1. 6-Hydroxydopamine (6-OHDA) administered in ovo enhanced in primary immune response to sheep red blood cells (SRBC) in chicks 2. Splenic norepinephrine levels increased during the peak anti-SRBC response. 3. Cell-mediated immunity as measured by delayed-type hypersensitivity to phytohemagglutinin-P (PHA-P) was not affected by treatment with 6-OHDA.
Department of Poultry Science, North Carolina State University, Raleigh.
H M
HM
Brown-Borg
F W
FW
Edens
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation / Q000187:drug effects*; D015306:Biogenic Monoamines / Q000378:metabolism; D001933:Brain Stem / Q000187:drug effects / Q000378:metabolism; D002060:Bursa of Fabricius / Q000187:drug effects / Q000378:metabolism; D002642:Chick Embryo / Q000187:drug effects*; D003345:Corticosterone / Q000097:blood; D007111:Immunity, Cellular / Q000187:drug effects; D016627:Oxidopamine / Q000633:toxicity*; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000187:drug effects*; D013950:Thymus Gland / Q000187:drug effects / Q000378:metabolism
D000906:Antibodies; D015306:Biogenic Monoamines; D016627:Oxidopamine; D003345:Corticosterone