[Decrease of pineal AMPc and TOH activity in the superior cervical ganglia after ablation of submaxillary glands in rats].
In order to investigate a possible functional relationship between the submandibular salivary gland (SSG) and the central nervous system (CNS), we have extirpated the salivary organs from thirty male rats. Twenty days after ablation both the pineal glands and the cervical superior ganglions (CSG) were dissected, homogenized and frozen until AMPc and TOH were assayed respectively. We observed a significant decrease in pineal AMPc (53.9 +/- 6.2 vs 76.1 +/- 7.6% of maximum value; p less than 0.02) which seems to be linked with a significant drop in TOH activity measured at CSG level (1.5 +/- 0.6 vs 3.7 +/- 0.9 nmoles of DOPA/h/pair GCS; p less than 0.03). Our results suggest that both findings might be due to the lack of NGF normally reaching the CSG from SSG. This data reinforces the idea of a functional link between SSG and CNS via the pineal gland.
Laboratoire de Physiologie, Faculté de Chirurgie dentaire, Université Montpellier-I.
B
B
Litovsky
R
R
Boyer
C
C
Pasqualini
B
B
Guibert
G
G
Alonso
S
S
Arancibia
D000818:Animals; D000242:Cyclic AMP / Q000032:analysis*; D003864:Depression, Chemical; D005728:Ganglia, Sympathetic / Q000201:enzymology*; D008297:Male; D010870:Pineal Gland / Q000737:chemistry*; D051381:Rats; D011919:Rats, Inbred Strains; D013363:Submandibular Gland / Q000601:surgery; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
D000242:Cyclic AMP; D014446:Tyrosine 3-Monooxygenase
Diminution de l'AMPc pinéal et de l'activité de la TOH dans le ganglion cervical supérieur après ablation des glandes sous-maxillaires chez le rat.