T cells and eosinophils in the pathogenesis of asthma.
Persistent asthma is characterized by chronic inflammation of the bronchial mucosa, where T cells and eosinophils are prominent. This article summarizes the evidence that asthmatic bronchial inflammation is initiated and propagated by cytokines secreted by activated T cells and other cells, and describes how the release of specific cytokines could result in local preferential accumulation and activation of eosinophils.
Corrigan
C J
CJ
Dept of Allergy and Clinical Immunology, National Heart and Lung Institute, London, UK.
Kay
A B
AB
D001249:Asthma / Q000209:etiology / Q000503:physiopathology*; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D004804:Eosinophils / Q000276:immunology*; D015870:Gene Expression; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000235:genetics; D006801:Humans; D007073:Immunoglobulin E / Q000502:physiology; D007249:Inflammation / Q000503:physiopathology; D009092:Mucous Membrane / Q000503:physiopathology; D012333:RNA, Messenger / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D016207:Cytokines; D012333:RNA, Messenger; D007073:Immunoglobulin E; D016178:Granulocyte-Macrophage Colony-Stimulating Factor