Gastrulation in the mouse: the role of the homeobox gene goosecoid.
Mouse goosecoid is a homeobox gene expressed briefly during early gastrulation. Its mRNA accumulates as a patch on the side of the epiblast at the site where the primitive streak is first formed. goosecoid-expressing cells are then found at the anterior end of the developing primitive streak, and finally in the anteriormost mesoderm at the tip of the early mouse gastrula, a region that gives rise to the head process. Treatment of early mouse embryos with activin results in goosecoid mRNA accumulation in the entire epiblast, suggesting that a localized signal induces goosecoid expression during development. Transplantation experiments indicate that the tip of the murine early gastrula is the equivalent of the organizer of the amphibian gastrula.
Blum
M
M
Molecular Biology Institute, University of California, Los Angeles 90024-1737.
Gaunt
S J
SJ
Cho
K W
KW
Steinbeisser
H
H
Blumberg
B
B
Bittner
D
D
De Robertis
E M
EM
D028341:Activins; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004268:DNA-Binding Proteins / Q000032:analysis*; D004627:Embryonic Induction / Q000187:drug effects / Q000235:genetics*; D005775:Gastrula / Q000187:drug effects; D015870:Gene Expression; D005801:Genes, Homeobox; D051956:Goosecoid Protein; D018398:Homeodomain Proteins; D007265:Inhibins / Q000494:pharmacology; D008648:Mesoderm / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000032:analysis; D012097:Repressor Proteins; D014157:Transcription Factors; D014981:Xenopus / Q000196:embryology
D004268:DNA-Binding Proteins; D051956:Goosecoid Protein; C497993:Gsc protein, mouse; D018398:Homeodomain Proteins; D012333:RNA, Messenger; D012097:Repressor Proteins; D014157:Transcription Factors; D028341:Activins; D007265:Inhibins