Identification of donor melanoma in a renal transplant recipient.
A patient with chronic renal failure received a closely matched cadaveric kidney. Approximately 3 months after transplantation, the patient developed a metastatic malignant melanoma. A large retroperitoneal mass consisting of large pleomorphic polygonal neoplastic cells was found close to the donated kidney. This tumor was diagnosed as a malignant melanoma. DNA analysis of this tumor, the donated kidney, and the recipient indicated that the melanoma originated from the donor. Although this is not the first report of a donated melanoma, it is the first report of definitive DNA analysis of the origin of the malignant cells.
Department of Pathology, University of Kansas Medical Center, Kansas City 66160-7232.
L J
LJ
Wilson
R T
RT
Horvat
L
L
Tilzer
A M
AM
Meis
L
L
Montag
M
M
Huntrakoon
D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000473:pathology; D008545:Melanoma / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D008875:Middle Aged; D009368:Neoplasm Transplantation; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D014019:Tissue Donors
D004273:DNA, Neoplasm