Photodynamic therapy in the management of neoplasms of the perianal skin.
Perianal extramammary Paget's disease, Bowen's disease, and squamous cell carcinoma are three entities that are very rarely reported. Overall, it is generally accepted that wide surgical excision is adequate treatment except under certain circumstances. Consideration has to be given to invasiveness, metastatic potential, multicentricity, and tendency to recur. We describe four patients who, following unsuccessful multiple attempts at achieving microscopically clear margins with surgical excision, were treated at Roswell Park Cancer Institute with photodynamic therapy with a surface illumination method. With a minimum follow-up of 6 months (more than 1 year in three patients), there have been no recurrences to date.
Petrelli
N J
NJ
Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263.
Cebollero
J A
JA
Rodriguez-Bigas
M
M
Mang
T
T
D000328:Adult; D000368:Aged; D001003:Anal Canal / Q000601:surgery; D000818:Animals; D001913:Bowen's Disease / Q000188:drug therapy*; D002278:Carcinoma in Situ / Q000188:drug therapy*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D017323:Dihematoporphyrin Ether / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010145:Paget Disease, Extramammary / Q000188:drug therapy*; D010778:Photochemotherapy; D012074:Remission Induction; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000188:drug therapy*; D016896:Treatment Outcome
D017323:Dihematoporphyrin Ether