[Primary hypothyroidism in normal thyroid gland morphology].
A 25 year old patient developed hypothyroidism with antibodies against thyroglobulin, thyroid microsomes and thyrotropin receptors. Thyroid 99m-technetium-uptake was 0%. Ultrasound investigation revealed a normal sized, homogenous thyroid gland. Histology showed lymphocyte infiltration but regular follicles. These results suggest the cause of hypothyroidism to be thyrotropin inhibiting immunoglobulins with no parenchyma-destroying properties.
Medizinische Kernklinik und Poliklinik, Univ.-Krankenhaus Eppendorf, Hamburg.
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Heik
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Wolf
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Greten
D000328:Adult; D001323:Autoantibodies / Q000096:biosynthesis*; D006801:Humans; D007037:Hypothyroidism / Q000276:immunology*; D018828:Immunoglobulins, Thyroid-Stimulating; D008297:Male; D011989:Receptors, Thyrotropin / Q000276:immunology; D013954:Thyroglobulin / Q000276:immunology; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000276:immunology*; D014463:Ultrasonography
D001323:Autoantibodies; D018828:Immunoglobulins, Thyroid-Stimulating; D011989:Receptors, Thyrotropin; C056626:thyroid microsomal antibodies; D013954:Thyroglobulin
Primäre Hypothyreose bei normaler Schilddrüsenmorphologie.