The metabolism of noradrenaline in the sheep and the effect of dry matter intake upon the production of a metabolite, urinary vanillylmandelic acid.
1. The metabolism of noradrenaline was investigated in the sheep using 3H-noradrenaline injected subcutaneously or intravenously. 2. Analysis of urine collected over 24 hr showed that the bulk of 3H-noradrenaline was rapidly degraded and excreted via the urine. The principle metabolite was the conjugated amine as well as monohydroxy phenyl glycol and vanillylmandelic acid (VMA) previously reported for the rat. 3. Urinary VMA from lambs of two breeds noted for differences in fat (Southdown and Suffolk) increased curvilinearly with dry matter intake and there was a significant breed difference in regression with intake. 4. It is feasible that differences in noradrenaline production could contribute to differences in body composition between breeds.
Ruakura Agricultural Centre, Hamilton, New Zealand.
E
E
Payne
B C
BC
Cope
J M
JM
Hughes
D E
DE
Phipps
D000818:Animals; D004435:Eating / Q000502:physiology*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D012756:Sheep / Q000378:metabolism* / Q000652:urine; D014642:Vanilmandelic Acid / Q000652:urine*
D014642:Vanilmandelic Acid; D009638:Norepinephrine