Stability index for enzymes deactivating by different mechanisms.
A quantitative procedure for estimating changes in enzyme stability upon chemical modification is presented. Stability index for different deactivation mechanisms is presented and applied to different enzyme deactivations. The stability index provides a convenient method of estimating changes in enzyme stability upon chemical modification.
Sadana
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Chemical Engineering Department, University of Mississippi, University 38677-9740.
Raju
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D000659:AMP Deaminase / Q000378:metabolism; D000447:Aldehydes / Q000494:pharmacology; D000818:Animals; D002417:Cattle; D004789:Enzyme Activation / Q000187:drug effects*; D004791:Enzyme Inhibitors; D004795:Enzyme Stability / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D008099:Liver / Q000201:enzymology; D008433:Mathematics; D009132:Muscles / Q000201:enzymology; D010763:Phosphorylase b / Q000378:metabolism; D011817:Rabbits; D013869:Thiolester Hydrolases / Q000378:metabolism; D000099301:Hydroxyacylglutathione Hydrolase
D000659:AMP Deaminase; D000447:Aldehydes; D004791:Enzyme Inhibitors; D010763:Phosphorylase b; D013869:Thiolester Hydrolases; D000099301:Hydroxyacylglutathione Hydrolase; C005556:propionaldehyde