[Rheumatoid arthritis. Changes in lymphocyte subsets under the effect of tiopronin].
Lymphocytes from 12 rheumatoid arthritis patients were phenotyped before and after a 2-month treatment with tiopronin. Originally reduced, CD4 CD45RA-T lymphocytes were shown to augment significantly. Abnormal activation (evaluated on HLA-DR and CD25 expression) of each cell population and sub-population was partially amended.
Lamour
A
A
Laboratoire d'Immunologie, CHU, Brest.
Paolozzi
L
L
Leroux
A M
AM
Le Goff
P
P
Youinou
P
P
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000188:drug therapy / Q000276:immunology; D015704:CD4 Antigens / Q000032:analysis; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D016827:CD8 Antigens / Q000032:analysis; D005260:Female; D006801:Humans; D017493:Leukocyte Common Antigens / Q000032:analysis; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000187:drug effects* / Q000276:immunology; D008625:Tiopronin / Q000494:pharmacology*
D015704:CD4 Antigens; D016827:CD8 Antigens; D008625:Tiopronin; D017493:Leukocyte Common Antigens
Polyarthrite rhumatoide: evolution des sous-populations lymphocytaires sous l'effet de la tiopronine.