A linkage map of mouse chromosome 19: definition of comparative mapping relationships with human chromosomes 10 and 11 including the MEN1 locus.
A linkage map of mouse Chromosome (Chr) 19 was constructed using an interspecific cross and markers defined by restriction fragment length variants. The map includes 20 markers, 9 of which had not been mapped previously in the mouse. The data further defined the relationship between genes on mouse Chr 19 and those on the long arm of human Chr 10 and the pericentric region of the long arm of human Chr 11. The comparative mapping analysis suggests that the proximal segment of mouse Chr 19 may contain the MEN1 locus and that the current study has identified additional genes that may be useful for positional cloning of this putative tumor suppressor gene.
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
J M
JM
Rochelle
M L
ML
Watson
R J
RJ
Oakey
M F
MF
Seldin
D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10; D002880:Chromosomes, Human, Pair 11; D003433:Crosses, Genetic; D004247:DNA / Q000032:analysis; D008040:Genetic Linkage; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D051379:Mice; D008809:Mice, Inbred C3H / Q000235:genetics*; D009377:Multiple Endocrine Neoplasia / Q000235:genetics*; D009115:Muridae / Q000235:genetics*; D015345:Oligonucleotide Probes; D012150:Polymorphism, Restriction Fragment Length
D005819:Genetic Markers; D015345:Oligonucleotide Probes; D004247:DNA