Further studies on the anti-nociceptive effect of vasopressin.
The possible interactions of pathways which mediate anti-nociception when stimulated by alpha 2-adrenoceptor agonists and arginine vasopressin (AVP) were investigated. Yohimbine, an alpha 2-antagonist, failed to modify the anti-nociceptive response of AVP. However, clonidine pretreatment, in sub-effective and effective doses, potentiated the anti-nociceptive response of a sub-effective dose of AVP. This potentiation was attenuated by yohimbine and completely antagonized by naloxone. These studies suggest that pathways related to the opioidergic system and those stimulated by alpha 2-agonists may be utilized by AVP in eliciting the anti-nociceptive response.
Ramaswamy
S
S
Department of Pharmacology, Jawaharial Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Shewade
D G
DG
Tyagi
M G
MG
Bapna
J S
JS
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D003000:Clonidine / Q000494:pharmacology; D008297:Male; D051379:Mice; D009270:Naloxone / Q000494:pharmacology; D015016:Yohimbine / Q000494:pharmacology
D000700:Analgesics; D001127:Arginine Vasopressin; D015016:Yohimbine; D009270:Naloxone; D003000:Clonidine