[Lipid metabolism in patients with insulin dependent diabetes. IV. Effect of sex, age, excess body weight, duration of diabetes, insulin dosage and family history on lipid metabolism in patients with insulin dependent diabetes].
The levels of the following blood serum lipid constituents: total cholesterol, triglycerides, phospholipids, HDL-cholesterol, apolipoproteins AI, AII and B, and lipoprotein fractions have been determined in patients with insulin-dependent diabetes in relation to sex, age, duration of diabetes, coexistence of obesity, insulin dosage and history of genetic predispositions. The age of the patients was between 1.3 and 22 years and the duration of the disease ranged between 3 months and 15 years. The analysis of the results revealed that sex, age, daily insulin dose and the known genetic predispositions have no influence on the values of the parameters of lipid metabolism. However, an increase in the levels of cholesterol, HDL-cholesterol, triglycerides and apolipoproteins AI and B was observed along with the progressing duration of the disease. An increase in the levels of cholesterol, apolipoprotein B and beta-lipoprotein, and a decrease in the level of alpha-lipoprotein have been found in diabetic children with coexisting obesity. The above analysis indicates that besides metabolic control of diabetes its duration and accompanying obesity may negatively influence the course of the disease contributing to the precocious development of atherosclerosis.
II Klinika Chorób Dzieci AM, Białymstoku.
M
M
Krawczuk-Rybak
J
J
Wójtowicz
M
M
Urban
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D005260:Female; D006801:Humans; D007223:Infant; D007328:Insulin / Q000008:administration & dosage; D008055:Lipids / Q000097:blood*; D008297:Male; D009765:Obesity / Q000150:complications; D012307:Risk Factors; D012737:Sex Factors
D007328:Insulin; D008055:Lipids
Stan gospodarki tłuszczowej u chorych na cukrzyce insulinozalezna Cześć IV. Wpływ płci, wieku pacjenta, nadmiaru masy ciała, czasu trwania cukrzycy, dawki insuliny oraz obciazeń rodzinnych na stan gospodarki tłuszczowej u chorych na cukrzyce insulinozalezna.