Effect of neutrophils on the growth of human pre-S1-reactive T-cells in vitro.
Granulocyte factor (GF) derives from the specific granules of polymorphonuclear neutrophils. GF possesses an immunoregulatory activity and augments the immune response to antigens in vitro and in vivo. The Pre-S1 sensitive T-cells reactive to Pre-S1 protein in vitro were developed from peripheral blood mononuclear cells of hepatitis B convalescent by in vitro Pre-S1 protein stimulation. The GF involvement in the activation and development of the Pre-S1 specific regulatory T-cells in vitro was studied.
Microbiology and Virology Center, Polish Academy of Sciences, Lódź.
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Z
Sułowska
K
K
Zeman
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H
Tchórzewski
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D006509:Hepatitis B / Q000276:immunology; D006514:Hepatitis B Surface Antigens; D006801:Humans; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D009504:Neutrophils / Q000276:immunology*; D011498:Protein Precursors; D013601:T-Lymphocytes / Q000276:immunology*
D000276:Adjuvants, Immunologic; D006514:Hepatitis B Surface Antigens; D011498:Protein Precursors; C050806:presurface protein 1, hepatitis B surface antigen