Characteristics of the T cell-mediated immune response to maedi-visna virus.
Virus-specific T cell-mediated immunity was investigated in healthy sheep persistently infected with the ruminant lentivirus maedi-visna. Visna-specific lymphocyte proliferation was demonstrated in response to both purified virions and recombinant p25, the major core protein of maedi-visna virus. The responding T cell population in this assay was mainly of the CD4+ phenotype, although in some individuals CD8+ T cells were also shown to respond to visna antigen in this system.
Department of Veterinary Pathology, University of Edinburgh, United Kingdom.
H T
HT
Reyburn
D J
DJ
Roy
B A
BA
Blacklaws
D R
DR
Sargan
N J
NJ
Watt
I
I
McConnell
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016827:CD8 Antigens / Q000276:immunology; D007111:Immunity, Cellular; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D011021:Pneumonia, Progressive Interstitial, of Sheep / Q000276:immunology*; D011994:Recombinant Proteins / Q000276:immunology / Q000494:pharmacology; D012756:Sheep; D013601:T-Lymphocytes / Q000276:immunology*; D014758:Viral Core Proteins / Q000276:immunology / Q000494:pharmacology; D014771:Virion / Q000276:immunology
D016827:CD8 Antigens; D011994:Recombinant Proteins; D014758:Viral Core Proteins