Frequencies of X-ray-induced chromosome translocations in human peripheral lymphocytes as detected by in situ hybridization using chromosome-specific DNA libraries.
In situ hybridization with chromosome-specific DNA libraries was used to analyse radiation-induced stable translocations in human peripheral blood lymphocytes. These data were compared with radiation-induced unstable-type aberrations (dicentrics) in the same samples. The results indicate that far more stable aberrations are induced by radiation in comparison to unstable aberrations.
Natarajan
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AT
MGC, Department of Radiation Genetics and Chemical Mutagenesis, State University of Leiden, The Netherlands.
Vyas
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RC
Darroudi
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F
Vermeulen
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D005260:Female; D015723:Gene Library; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000528:radiation effects / Q000648:ultrastructure; D009693:Nucleic Acid Hybridization; D014178:Translocation, Genetic; D014965:X-Rays