Structure-activity relationships of synthetic diosgenyl diglycosides.
The haemolytic and antifungal activities of six synthetic diosgenyl diglycosides and diosgenyl maltotrioside were compared with each other and with those of the parent glucoside. In general, the haemolytic activity of each of these glycosides was higher than, and the antifungal activity as strong as, that of the glucoside. However, both activities of the lactoside were much lower than those of the others.
Faculty of Pharmaceutical Sciences, Kinki University, Higashiosaka, Japan.
M
M
Takechi
S
S
Shimada
Y
Y
Tanaka
D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002240:Carbohydrate Sequence; D006027:Glycosides / Q000138:chemical synthesis / Q000494:pharmacology*; D006460:Hemolysin Proteins / Q000737:chemistry*; D008969:Molecular Sequence Data; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D006027:Glycosides; D006460:Hemolysin Proteins