The cytoprotective effect of zinc L-carnosine on ethanol-induced gastric gland damage in rabbits.
The effects of zinc L-carnosine on the damaging actions of ethanol were examined in rabbit isolated gastric glands. Ethanol (8%, v/v) incubation produced a 50% viability of the gland populations and released a significant amount (38%) of the total lactate dehydrogenase (an index of membrane injury) of the glands. Zinc L-carnosine pre-incubation for 15 min markedly prevented these actions of ethanol; however, L-carnosine by itself did not have these effects. The findings indicate that zinc ion but not carnosine in the zinc L-carnosine molecule possesses cytoprotective action against ethanol-induced gastric gland damage in rabbits.
Cho
C H
CH
Department of Pharmacology, Faculty of Medicine, University of Hong Kong.
Hui
W M
WM
Chen
B W
BW
Luk
C T
CT
Lam
S K
SK
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D002336:Carnosine / Q000494:pharmacology*; D000431:Ethanol / Q000633:toxicity*; D005088:Exocrine Glands / Q000166:cytology / Q000187:drug effects; D005753:Gastric Mucosa / Q000187:drug effects; D066298:In Vitro Techniques; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D011817:Rabbits; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000473:pathology; D015032:Zinc / Q000494:pharmacology*
D000897:Anti-Ulcer Agents; D000431:Ethanol; D002336:Carnosine; D007770:L-Lactate Dehydrogenase; D015032:Zinc