Membrane protein insertion into the endoplasmic reticulum--another channel tunnel?
The synthesis of biological membranes requires the insertion of proteins into a lipid bilayer. The rough endoplasmic reticulum of eukaryotic cells is a principal site of membrane biogenesis. The insertion of proteins into the membrane of the endoplasmic reticulum is mediated by a resident proteinaceous machinery. Over the last five years several different experimental approaches have provided information about the components of the machinery and how it may function.
European Molecular Biology Laboratory, Heidelberg, Germany.
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D000818:Animals; D002451:Cell Compartmentation; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000378:metabolism*; D005656:Fungal Proteins / Q000378:metabolism; D007425:Intracellular Membranes / Q000378:metabolism; D046911:Macromolecular Substances; D008322:Mammals / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism*; D008954:Models, Biological; D015388:Organelles / Q000378:metabolism; D011498:Protein Precursors / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D021382:Protein Sorting Signals / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000378:metabolism
D005656:Fungal Proteins; D046911:Macromolecular Substances; D008565:Membrane Proteins; D011498:Protein Precursors; D021382:Protein Sorting Signals