Effects of alpha-tocopherol and tocotrienols on blood pressure and linoleic acid metabolism in the spontaneously hypertensive rat (SHR).
Both alpha-tocopherol and a 1:1.7 mixture of alpha-tocopherol and tocotrienols at a 0.2% dietary level significantly depressed the age-related increase in the systolic blood pressure of spontaneously hypertensive rats (SHRs) after 3 weeks of feeding. The aortic production of prostacyclin was increased 1.5 times both by alpha-tocopherol and a tocotrienol mixture, suggesting a possible relevance to their hypotensive effect. These vitamins did not influence the delta 6- and delta 5-desaturase activities of liver microsomes, but fatty acid profiles of the liver phospholipids predicted a reduction of linoleic acid desaturation. These effects were in general more clear with tocotrienols than with alpha-tocopherol. Platelet aggregation by 5 microM ADP remained uninfluenced. Thus, tocotrienols may have effects on various lipid parameters somewhat different from those of alpha-tocopherol.
Laboratory of Nutrition Chemistry, Kyushu University School of Agriculture, Fukuoka, Japan.
K
K
Koba
K
K
Abe
I
I
Ikeda
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M
Sugano
D000818:Animals; D001013:Aorta, Thoracic / Q000378:metabolism; D016718:Arachidonic Acid / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D000090943:Delta-5 Fatty Acid Desaturase; D011464:Epoprostenol / Q000096:biosynthesis; D044943:Fatty Acid Desaturases / Q000378:metabolism; D005227:Fatty Acids / Q000032:analysis; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000378:metabolism*; D050602:Linoleoyl-CoA Desaturase; D008055:Lipids / Q000032:analysis; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D010713:Phosphatidylcholines / Q000378:metabolism; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D011918:Rats, Inbred SHR / Q000378:metabolism*; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000494:pharmacology*
D000090943:Delta-5 Fatty Acid Desaturase; D005227:Fatty Acids; D008041:Linoleic Acids; D008055:Lipids; D010713:Phosphatidylcholines; D014810:Vitamin E; D016718:Arachidonic Acid; D019787:Linoleic Acid; D011464:Epoprostenol; D044943:Fatty Acid Desaturases; D050602:Linoleoyl-CoA Desaturase