Vector incrimination and effects of antimalarial drugs on malaria transmission and control in the Amazon basin of Brazil.
World ecosystems differ significantly and a multidisciplinary malaria control approach must be adjusted to meet these requirements. These include a comprehensive understanding of the malaria vectors, their behavior, seasonal distribution and abundance, susceptibility to insecticides (physiological and behavioral), methods to reduce the numbers of human gametocyte carriers through effective health care systems and antimalarial drug treatment, urban malaria transmission versus rural or forest malaria transmission, and the impact of vaccine development. Many malaria vectors are members of species complexes and individual relationships to malaria transmission, seasonal distribution, biting behavior, etc. is poorly understood. Additionally, malaria patients are not examined for circulating gametocytes and both falciparum and vivax malaria patients may be highly infective to mosquitoes after treatment with currently used antimalarial drugs. Studies on the physiological and behavioral effects of DDT and other insecticides are inconclusive and need to be evaluated.
Department of Entomology, Walter Reed Army Institute of Research, Washington, DC 20307-5100.
T A
TA
Klein
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Lima
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Toda Tang
D000818:Animals; D000852:Anopheles / Q000469:parasitology; D000962:Antimalarials / Q000627:therapeutic use*; D001938:Brazil / Q000453:epidemiology; D002353:Carrier State / Q000453:epidemiology; D004463:Ecology; D006801:Humans; D007303:Insect Vectors / Q000469:parasitology; D008288:Malaria / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control / Q000635:transmission*; D009032:Mosquito Control; D010961:Plasmodium / Q000302:isolation & purification
D000962:Antimalarials