[The effect of adrenoblockers on the neurons of the lateral hypothalamus under the action of pentagastrin].
To test the hypothesis of interaction pentagastrin (PG) noradrenaline (NA) in central neurochemical mechanisms of food motivation, we studied the activity of single neurons in lateral hypothalamus (LH) after s.c. PG injection. Following PG injection microiontophoresis (MIF) of propranolol prazosin was made. PG-induced changes were similar to neuronal activity in rabbits LH after 24-hour food deprivation in 59%. Propranolol-induced changes were following firing pattern in the process of food uptake in 68%. Prazosin MIF induced firing pattern of neuronal activity of saturated rabbits in 60%.
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AP
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D004347:Drug Interactions; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology; D007026:Hypothalamic Area, Lateral / Q000187:drug effects* / Q000502:physiology; D007478:Iontophoresis; D008297:Male; D008839:Microelectrodes; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D010418:Pentagastrin / Q000494:pharmacology*; D011224:Prazosin / Q000008:administration & dosage; D011433:Propranolol / Q000008:administration & dosage; D011817:Rabbits
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D011433:Propranolol; D010418:Pentagastrin; D011224:Prazosin
Vliianie adrenoblokatorov na neĭrony lateral'nogo gipotalamusa pri deĭstvii pentagastrina.