Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.
Disturbances in dopamine neurotransmission have been postulated to underlie schizophrenia. We report data from two independent studies of a BalI polymorphism in the dopamine D3 receptor gene in patients with schizophrenia. In both studies, more patients than controls were homozygous (p = 0.005, p = 0.008). When pooled data were analysed, this difference was highly significant (p = 0.0001) with a relative risk of schizophrenia in homozygotes of 2.61 (95% confidence intervals 1.60-4.26).
Crocq
M A
MA
Centre Hospitalier, Rouffach, France.
Mant
R
R
Asherson
P
P
Williams
J
J
Hode
Y
Y
Mayerova
A
A
Collier
D
D
Lannfelt
L
L
Sokoloff
P
P
Schwartz
J C
JC
D000328:Adult; D000368:Aged; D000483:Alleles; D001483:Base Sequence; D016009:Chi-Square Distribution; D002893:Chromosomes, Human, Pair 3; D004247:DNA / Q000235:genetics; D015252:Deoxyribonucleases, Type II Site-Specific; D005260:Female; D005787:Gene Frequency; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D012150:Polymorphism, Restriction Fragment Length; D011954:Receptors, Dopamine / Q000235:genetics*; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics*
C493593:DRD3 protein, human; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D004247:DNA; D015252:Deoxyribonucleases, Type II Site-Specific; C060616:TGGCCA-specific type II deoxyribonucleases