Structural studies on H2-antagonists: crystal and molecular structure of N-cyano-N'-methyl-N"-(2-[(2-amino-5-thiazolyl)methylthio]ethyl) guanidine and N-cyano-3-[(2-guanidino-5-thiazolyl)methylthio]propionamidine.
The crystal and molecular structures of N-cyano-N'-methyl-N"-(2-[(2-amino-5-thiazolyl) methylthio] ethyl) guanidine and N-cyano-3-[(2-guanidino-5-thiazolyl)methylthio]propionamidine are reported. Both molecules are in an extended conformation. In all two crystals a system of hydrogen bonds links the molecules in a three-dimensional network. A comparison with the structure of cimetidine and famotidine is also included.
Ianelli
S
S
Istituto di Chimica Generale ed Inorganica, CNR-Università di Parma, Italia.
Pelizzi
G
G
D002927:Cimetidine / Q000737:chemistry; D003460:Crystallization; D015738:Famotidine / Q000737:chemistry; D006146:Guanidines / Q000737:chemistry*; D006635:Histamine H2 Antagonists / Q000737:chemistry*; D008968:Molecular Conformation; D013844:Thiazoles / Q000737:chemistry*; D014961:X-Ray Diffraction
D006146:Guanidines; D006635:Histamine H2 Antagonists; D013844:Thiazoles; C077132:N-cyano-N'-methyl-N''-(2-((2-amino-5-thiazolyl)methylthio)ethyl)guanidine; C077133:N-cyano-3-((2-guanidino-5-thiazolyl)methylthio)propionamidine; D015738:Famotidine; D002927:Cimetidine