Cloning high molecular weight DNA fragments by the bacteriophage P1 system.
The cloning of high molecular weight genomic DNA promises to provide the means of mapping chromosomes, isolating genes, and understanding long-range effects on gene expression. This review describes the background and some recent advances in cloning of high molecular weight DNA using the bacteriophage P1 system.
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Cancer Biology Program, Du Pont Merck Pharmaceutical Company, Wilmington, DE 19880-0328, USA.
D017101:Bacteriophage P1 / Q000235:genetics*; D003001:Cloning, Molecular / Q000379:methods*; D004274:DNA, Recombinant / Q000235:genetics*; D015723:Gene Library; D005822:Genetic Vectors / Q000235:genetics; D006801:Humans
D004274:DNA, Recombinant