Possible induction of intercellular adhesion molecule-1 (ICAM-1) expression on endothelial cells by platelet-activating factor (PAF).
We demonstrated that PAF and IL-1 markedly induce ICAM-1 expression on endothelial cells. These findings suggest that PAF not only modulates inflammation by the attraction and activation of eosinophils or by platelet activation, but also intensifies such phenomena by induction of ICAM-1 expression on endothelial cells.
Fourth Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan.
J
J
Chihara
I
I
Maruyama
H
H
Yasuba
A
A
Yasukawa
T
T
Yamamoto
D
D
Kurachi
T
T
Mouri
M
M
Seguchi
S
S
Nakajima
D015703:Antigens, CD / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D007375:Interleukin-1 / Q000494:pharmacology; D010972:Platelet Activating Factor / Q000494:pharmacology*
D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D007375:Interleukin-1; D010972:Platelet Activating Factor; D018799:Intercellular Adhesion Molecule-1