Alterations of cytoplasmic enzyme activities of liver in rats fed on diets containing orotic acid with dietary fibers.
1. Rats were fed with diets containing orotic acid with dietary fibers to induce alteration of lipid metabolism and cytoplasmic enzyme activities in the livers. Concentrations of blood glucose, serum insulin and free fatty acids (FFA) were measured. 2. In CP (cellulose + orotic acid) group compared to basal (cellulose - orotic acid) or CBH (corn bran hemicellulose + cellulose + orotic acid) groups, glucose-6-phosphate dehydrogenase, pyruvate kinase and ATP citrate lyase activities and FFA concentration were decreased according to lipid accumulation of livers. 3. In the CBH group, glycerokinase activity was higher than basal group.
Department of Bioproduction Science, Faculty of Horticulture, Chiba University, Matsudo, Japan.
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Miyasaka
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Sanada
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D003593:Cytoplasm / Q000201:enzymology*; D004032:Diet; D004043:Dietary Fiber / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D007328:Insulin / Q000097:blood; D008099:Liver / Q000201:enzymology*; D008297:Male; D009929:Organ Size; D009963:Orotic Acid / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D001786:Blood Glucose; D004043:Dietary Fiber; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D009963:Orotic Acid