Embryonal germ-layer antigens: target for autoimmunity.
Histopathological analysis of some systemic autoimmune diseases and syndromes led us to the conclusion that the common feature of the organs involved might be their embryonal origin. We suggest that organs derived from the same germ layer express common germ-layer-specific antigens. Such antigens could serve as target antigens for the autoimmune response.
Clinical Immunology and Allergy Unit, Hadassah University Hospital, Ein-Kerem, Jerusalem, Israel.
B
B
Tadmor
C
C
Putterman
Y
Y
Naparstek
D001323:Autoantibodies / Q000096:biosynthesis; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000196:embryology / Q000209:etiology* / Q000276:immunology; D004475:Ectoderm / Q000276:immunology; D005855:Germ Layers / Q000276:immunology*; D006801:Humans; D008648:Mesoderm / Q000276:immunology; D009928:Organ Specificity
D001323:Autoantibodies; D001324:Autoantigens