Receptor guanylyl cyclases.
Three different guanylyl cyclase cell receptors are known, but others will likely be discovered within the next few years. The general function of these receptors appear to relate to the regulation of fluid volume or fluid movement. New receptors, or possibly the currently known receptors, therefore, may be discovered in areas of the body where fluid volume regulation is important. Such fluids whose volume or composition might be regulated by guanylyl cyclase receptors include synovial fluid, uterine/oviductal luminal fluid, follicular fluid, aqueous humor, cerebral spinal fluid, seminiferous tubule luminal fluid, epididymal luminal fluid, seminal plasma, and airway luminal fluid. The function of the heterodimeric forms of guanylyl cyclase appear to relate to a primary regulation of nitric oxide (or similar molecules) concentrations, which are in turn regulated by a Ca2+/calmodulin-sensitive nitric oxide synthase.
Wong
S K
SK
Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235.
Garbers
D L
DL
D000227:Adenine Nucleotides / Q000502:physiology; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002451:Cell Compartmentation; D002462:Cell Membrane / Q000201:enzymology; D006162:Guanylate Cyclase / Q000737:chemistry / Q000502:physiology*; D008024:Ligands; D008969:Molecular Sequence Data; D010247:Paramecium / Q000201:enzymology; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012160:Retina / Q000502:physiology; D013768:Tetrahymena / Q000201:enzymology
D000227:Adenine Nucleotides; D008024:Ligands; D011956:Receptors, Cell Surface; D006162:Guanylate Cyclase