Evolution of phenotypic memory T cells in HIV-1 infected infants and children.
Infants are reported to be devoid of memory T cells at birth but acquired them with time. A cross-sectional study of peripheral blood mononuclear cells from HIV-infected and uninfected infants and children that bear the CD4R0 antigen was undertaken to describe the development of memory T cells. Linear regression lines derived from the data revealed increasing percentages of memory CD4 and CD8 cells in the uninfected children. Memory CD4 cells in the infected children were detected at a frequency equal to or greater than that seen in uninfected children until 6 months of age but subsequently declined with age. In contrast, memory CD8 cells were found to be significantly increased in HIV-infected children early in life with a rate of increase similar to that seen in the uninfected population. This increase in memory CD8 cells may facilitate the early diagnosis of HIV infection.
Department of Pediatrics, New York University Medical Center, Bellevue Hospital Center, New York 10016.
W
W
Borkowsky
T
T
Moore
K
K
Krasinski
K O
KO
Ajuang-Simbiri
R
R
Holzman
D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016827:CD8 Antigens / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory / Q000235:genetics; D007223:Infant; D007231:Infant, Newborn; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology*
D016827:CD8 Antigens