Basic mechanisms of the epilepsies.
To understand the fundamental pathophysiology of the epilepsies, the chronic changes of structure and function in the brain that distinguish them must be identified and the basic mechanisms by which these changes come about need to be delineated. Recently, progress has been made along these lines, identifying morphological and operational differences in epileptic brains, both those from humans and those from animals, as well as alterations in gene activation brought about by seizures.
Lothman
E W
EW
Department of Neurology, University of Virginia, Charlottesville.
D000818:Animals; D001921:Brain / Q000503:physiopathology; D001931:Brain Mapping; D004195:Disease Models, Animal; D004827:Epilepsy / Q000503:physiopathology*; D006801:Humans; D009433:Neural Inhibition / Q000502:physiology; D009479:Neuropeptides / Q000502:physiology; D018377:Neurotransmitter Agents / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology
D009479:Neuropeptides; D018377:Neurotransmitter Agents