Apolipoprotein epsilon 4 homozygosity in young men with coronary heart disease.
We have compared apolipoprotein E gene polymorphism in 91 Australian men aged 30-50 who had been referred for coronary angioplasty and in 172 healthy younger men. 5 of the 19 patients who were less than 40 years of age were homozygous for the epsilon 4 allele, representing a 16-fold increase in prevalence compared with controls. In patients aged 40-50 the epsilon 4 allele frequency was 60% higher than it was in controls. Inheritance of epsilon 4 seems to confer risk of premature ischaemic heart disease in males, homozygotes being especially at risk at a younger age.
Department of Biochemistry, Royal Perth Hospital, Western Australia.
F M
FM
van Bockxmeer
C D
CD
Mamotte
D000328:Adult; D017130:Angioplasty; D001057:Apolipoproteins E / Q000235:genetics*; D003327:Coronary Disease / Q000235:genetics*; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D015995:Prevalence; D012307:Risk Factors
D001057:Apolipoproteins E; D008074:Lipoproteins