The role of V-ATPase in neuronal and endocrine systems.
Synaptic vesicles have important roles in the neural transmission at nerve terminals: the storage and the controlled exocytosis of neurotransmitters. At least two different factors are responsible for the concentration process: the vacuolar-type H(+)-ATPase (V-ATPase), establishing an electrochemical gradient of protons, and specific transport systems for transmitters. We will discuss our recent progress on the energy-transducing systems in synaptic vesicles: (1) structural aspects of V-ATPase; (2) energy coupling of transport of transmitters; (3) reconstitution of transporters; (4) effects of neurotoxins and neuron blocking agents; (5) function of synaptic-vesicle-like microvesicles from endocrine tissues.
Department of Organic Chemistry and Biochemistry, Osaka University, Japan.
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Moriyama
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Maeda
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Futai
D000251:Adenosine Triphosphatases / Q000737:chemistry / Q000502:physiology*; D000818:Animals; D015394:Molecular Structure; D009490:Neurosecretory Systems / Q000201:enzymology*; D018377:Neurotransmitter Agents / Q000378:metabolism; D013572:Synaptic Vesicles / Q000201:enzymology; D025262:Vacuolar Proton-Translocating ATPases; D014617:Vacuoles / Q000201:enzymology
D018377:Neurotransmitter Agents; D000251:Adenosine Triphosphatases; D025262:Vacuolar Proton-Translocating ATPases