Identical photosensitizing activities of a sulfonated aluminium phthalocyanine on human erythroleukemia cell lines susceptible or resistant to the cytotoxic activity of doxorubicin.
In this paper we report that a human erythroleukemia cell line made 100 times more resistant than the parental line to the cytostatic activity of doxorubicin and spontaneously 500-1000 times more resistant to the cytostatic activity of an unrelated drug, namely taxol, exhibits on the other hand unchanged susceptibility to the photosensitizing activity of a sulfonated phthalocyanine.
Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, Gif sur Yvette, France.
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Giannotti
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Werner
D000970:Antineoplastic Agents / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000494:pharmacology*; D004351:Drug Resistance; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D004915:Leukemia, Erythroblastic, Acute; D009942:Organometallic Compounds / Q000494:pharmacology*; D017239:Paclitaxel / Q000494:pharmacology; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D007211:Indoles; D009942:Organometallic Compounds; D011838:Radiation-Sensitizing Agents; C048577:aluminum tetrasulfophthalocyanine; D004317:Doxorubicin; D017239:Paclitaxel