Chelating agent reversal of cadmium effects on ionic transport in the isolated frog skin (Rana temporaria).
1. The application of 1 mM CdCl2 to the outside surface of frog skin causes a large increase in the potential difference (PD) across the skin and in the short-circuit current (SCC); the subsequent addition of selected dithiocarbamate chelating agents (which by themselves have no effect on PD or SCC) restored both electrical parameters to values close to initial levels. 2. The response observed on addition of the chelating agents indicates that the effect of CdCl2 is reversible and that the complexed ions do not possess the ability to initiate corresponding changes in the transepithelial ion transport processes in the frog skin.
Laboratory of Renal Physiology, Sechenov Institute of Evolutionary Physiology and Biochemistry, St Petersburg, Russia.
Y V
YV
Natochin
M M
MM
Jones
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002104:Cadmium; D015913:Chelation Therapy; D066298:In Vitro Techniques; D007477:Ions; D015394:Molecular Structure; D011896:Rana temporaria / Q000378:metabolism*; D012867:Skin / Q000187:drug effects*
D007477:Ions; D002104:Cadmium