Comparative study of the enzymatic, hemorrhagic, procoagulant and anticoagulant activities of some animal venoms.
1. The enzymatic, hemorrhagic, procoagulant and anticoagulant activities of venoms of some animals including snakes, lizards, toads, scorpions, spider, wasps, bees and ants were compared. 2. Snake venom was the richest source of enzymes among the animal venoms. Most other animal venoms were devoid of phosphodiesterase, L-amino acid oxidase, alkaline phosphomonoesterase and acetylcholinesterase activities and only a few exhibited arginine ester hydrolase activity. These venoms, however, exhibited wide ranges of protease, 5'-nucleotidase and hyaluronidase activities. Most of the animal venoms examined exhibited some phospholipase A activity. 3. Other than snake venoms, only venoms of the toad Bufo calamita and the lizards were hemorrhagic, and only venoms of the social wasps, social bees and harvester ant exhibited strong anticoagulant activity. Procoagulant activity occurs only in snake venoms.
Tan
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Department of Biochemistry, University of Malaya, Kuala Lumpur.
Ponnudurai
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D000664:Amphibian Venoms / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D000862:Ant Venoms / Q000378:metabolism / Q000494:pharmacology; D000925:Anticoagulants / Q000494:pharmacology*; D001514:Bee Venoms / Q000378:metabolism / Q000494:pharmacology; D001777:Blood Coagulation; D004798:Enzymes / Q000378:metabolism*; D006470:Hemorrhage / Q000139:chemically induced*; D008116:Lizards; D051379:Mice; D011817:Rabbits; D012604:Scorpion Venoms / Q000378:metabolism / Q000494:pharmacology; D012910:Snake Venoms / Q000378:metabolism / Q000494:pharmacology; D014688:Venoms / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D014862:Wasp Venoms / Q000378:metabolism / Q000494:pharmacology
D000664:Amphibian Venoms; D000862:Ant Venoms; D000925:Anticoagulants; D001514:Bee Venoms; D004798:Enzymes; D012604:Scorpion Venoms; D012910:Snake Venoms; D014688:Venoms; D014862:Wasp Venoms