Effect of diethyl maleate on glutathione, hepatic and renal cortical perfusion, and portal 6-ketoPGF1 alpha and TxB2 levels in swine.
1. Effects of diethyl maleate (DEM) mediated glutathione (GSH) depletion on hepatic and renal cortical blood flow (perfusion), plasma GSH, and portal prostacyclin (6-ketoPGF1 alpha) and thromboxane (TxB2) were determined in anaesthetized swine. 2. Although DEM depleted hepatic GSH to 25% of control, plasma GSH increased 10-fold in comparison to controls. DEM caused a drop in blood pressure and renal cortical perfusion but had no effect on hepatic perfusion or portal 6-ketoPGF1 alpha or TxB2 levels. 3. Possibly, the unexpected rise in plasma GSH may have inhibited prostanoid synthesis, preventing any alterations in tissue perfusion that may have occurred following tissue GSH depletion.
Department of Animal and Poultry Sciences, University of Arkansas, Fayetteville 72701.
W
W
Bottje
R
R
Glahn
K
K
Beers
H
H
Nejad
K
K
Holmes
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism*; D000818:Animals; D005260:Female; D005978:Glutathione / Q000097:blood*; D007672:Kidney Cortex / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D008298:Maleates / Q000494:pharmacology*; D010477:Perfusion; D011169:Portal Vein / Q000187:drug effects / Q000378:metabolism; D013552:Swine / Q000378:metabolism*; D013929:Thromboxane B2 / Q000378:metabolism*
D008298:Maleates; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; C014476:diethyl maleate; D005978:Glutathione