The erbB-3 gene in human pancreatic cancer.
Abnormalities of the type 1 growth factor receptor family have been implicated in the pathogenesis of pancreatic cancer. There is evidence for a potential autocrine loop involving overexpression of the epidermal growth factor (EGF) receptor and its ligands, as well as overexpression of the erbB-2 receptor. A third member of this receptor family, erbB-3, has recently been recognized and found to be abnormally expressed in some types of human cancer. In this study we show that overexpression of the erbB-3 protein occurs very frequently in carcinoma of the exocrine pancreas and also in chronic pancreatitis. We found no evidence of amplification or rearrangement of the erbB-3 gene by Southern blot analysis of DNA from pancreatic cancer cells lines.
Molecular Pathology Laboratory, Hammersmith Hospital, London, U.K.
N R
NR
Lemoine
M
M
Lobresco
H
H
Leung
C
C
Barton
C M
CM
Hughes
S A
SA
Prigent
W J
WJ
Gullick
G
G
Klöppel
D000595:Amino Acid Sequence; D015139:Blotting, Southern; D002460:Cell Line; D002908:Chronic Disease; D066246:ErbB Receptors / Q000235:genetics; D005784:Gene Amplification; D015870:Gene Expression / Q000235:genetics*; D015321:Gene Rearrangement; D006801:Humans; D007150:Immunohistochemistry; D008969:Molecular Sequence Data; D018739:Oncogene Proteins v-erbB; D010179:Pancreas / Q000737:chemistry; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000378:metabolism; D010195:Pancreatitis / Q000235:genetics / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000032:analysis / Q000235:genetics*; D020893:Receptor, ErbB-3; D015682:Retroviridae Proteins, Oncogenic / Q000235:genetics*
D018739:Oncogene Proteins v-erbB; D011518:Proto-Oncogene Proteins; D015682:Retroviridae Proteins, Oncogenic; D066246:ErbB Receptors; D020893:Receptor, ErbB-3