[The withdrawal syndrome and lipid peroxidation during the chronic administration of narcotic analgesics to rats].
Diverse behavioral disorders and the intensity of lipid peroxidation (LPO) of biological membranes were estimated in different rat tissues after the 7-day administration and subsequent withdrawal of morphine or promedol. 24 hours after the withdrawal of the analgetics the demonstrated a high initial level of motor activity in the open field. Naloxone, an antagonist of opiate receptors, potentiated motor activity and the intensity of withdrawal syndrome (by 160%) in rats with morphine rather than promedol dependence. The behavioral disorders in dependent animals were accompanied by LPO activation in liver and brain membranes.
Konstantinopol'skiĭ
M A
MA
Pirozhkov
S V
SV
Solov'eva
A G
AG
Panchenko
L F
LF
Barkov
N K
NK
D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000009:adverse effects; D009021:Morphine Dependence / Q000503:physiopathology; D009270:Naloxone / Q000008:administration & dosage; D011396:Promedol / Q000008:administration & dosage / Q000009:adverse effects; D051381:Rats; D017208:Rats, Wistar; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*; D019966:Substance-Related Disorders / Q000503:physiopathology; D013997:Time Factors
D000701:Analgesics, Opioid; D009270:Naloxone; D011396:Promedol; D009020:Morphine
Sindrom otmeny i perekisnoe okislenie lipidov pri khronicheskom vvedenii krysam narkotichyeskikh anal'getikov.