Inhibition of wheat embryo calcium-dependent protein kinase and other kinases by mangostin and gamma-mangostin.
The hull of the fruit of the mangosteen tree (Garcinia mangostana) contains four inhibitors of plant Ca(2+)-dependent protein kinase. Two of these inhibitors have been purified and identified as the xanthones 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H- xanthen-9-one (mangostin) and 1,3,6,7-tetrahydroxy-2,8-bis(3-methyl-2-butenyl)- 9H-xanthen-9-one (gamma-mangostin). Both xanthones also inhibit avian myosin light chain kinase and rat liver cyclic AMP-dependent protein kinase. This is the first report of inhibition of plant and animal second messenger-regulated protein kinases by plant-derived xanthones.
Department of Chemistry, La Trobe University, Bundoora, Victoria, Australia.
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Jinsart
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Ternai
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Buddhasukh
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Polya
D000595:Amino Acid Sequence; D008969:Molecular Sequence Data; D010946:Plants, Medicinal / Q000737:chemistry*; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases; D014197:Trees; D014908:Triticum / Q000201:enzymology*; D014966:Xanthenes / Q000302:isolation & purification / Q000494:pharmacology*; D044004:Xanthones; D017871:Calcium-Calmodulin-Dependent Protein Kinases
D047428:Protein Kinase Inhibitors; D011494:Protein Kinases; D014966:Xanthenes; D044004:Xanthones; D017871:Calcium-Calmodulin-Dependent Protein Kinases; C021053:mangostin