Differential expression of translation-associated genes in benign and malignant human breast tumours.
The human gene sequences encoding the translation-associated functions of alpha-subunit of elongation factor 1 (EF-1 alpha) and the ubiquitin carboxyl extension protein (HUBCEP80) have been isolated by differential cDNA screening, and found to have significantly higher levels of expression in fibroadenomas (benign) compared with carcinomas (malignant) of the breast. These data parallel our previous findings that the acidic ribosomal phosphoprotein P2 also has higher expression levels in the benign breast tumours (Sharp et al., 1990). In situ hybridisation has shown these genes to be expressed predominantly in the epithelium of breast tumours.
University/ICI Joint Laboratory, University of Leicester, UK.
S M
SM
Adams
M G
MG
Sharp
R A
RA
Walker
W J
WJ
Brammar
J M
JM
Varley
D000232:Adenofibroma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D000595:Amino Acid Sequence; D001483:Base Sequence; D015152:Blotting, Northern; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D002277:Carcinoma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D003001:Cloning, Molecular; D015342:DNA Probes; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D015723:Gene Library; D006801:Humans; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000494:pharmacology* / Q000627:therapeutic use; D011061:Poly A / Q000235:genetics / Q000302:isolation & purification; D014176:Protein Biosynthesis; D012313:RNA / Q000235:genetics / Q000302:isolation & purification; D015347:RNA Probes; D012333:RNA, Messenger
D015342:DNA Probes; D004273:DNA, Neoplasm; D010456:Peptides, Cyclic; D015347:RNA Probes; D012333:RNA, Messenger; C072534:SDZ 280 446; D011061:Poly A; D012313:RNA