Skin virulence of attenuated pseudorabies virus (PRV) strains.
After intradermal inoculation of the attenuated pseudorabies virus (PRV) strains, Bartha, MK35 (gI+) and MK35-T-2 (gI-) to rabbits, they caused local inflammatory nodules with oedema reddiness and necrosis. The specifity of these reactions was confirmed by their inhibition with anti-PRV serum. The minimal dose that caused visible skin reaction was about 10(2) TCID50/ml for Bartha and MK35-T-2 (gI-) strains and over 10(4) TCID50/ml for the MK35 (gI+) strain. It is assumed that the established residual skin virulence can serve as an additional distinction marker for attenuated PRV strains.
Haralambiev
H
H
Veterinary Research and Production Institute of Biopreparations, Vratza, Bulgaria.
Nikolov
T
T
Haralambieva
E
E
Yotov
M
M
D000818:Animals; D006168:Guinea Pigs; D011558:Herpesvirus 1, Suid / Q000472:pathogenicity; D007271:Injections, Intradermal; D022421:Pseudorabies Vaccines; D011817:Rabbits; D012756:Sheep; D012867:Skin / Q000473:pathology; D013552:Swine; D014613:Vaccines, Attenuated / Q000009:adverse effects*; D014774:Virulence
D022421:Pseudorabies Vaccines; D014613:Vaccines, Attenuated