Azelastine reduces allergen-induced nasal response: a clinical and rhinomanometric assessment.
The effect of azelastine 2 mg b.d. p.o. for 10 days on grass pollen-induced nasal responses in 16 patients with grass pollen allergic rhinitis has been assessed. The study was a double blind, randomized, placebo controlled, crossover trial, with a 10-14 day wash-out period. Patients were challenged with grass pollen before and after placebo and azelastine. The response was assessed by measurement of nasal resistance using active posterior rhinomanometry, by weighing nasal secretions, and by counting sneezes. The sensation of nasal obstruction was assessed with a visual analogue scale. After measurement of baseline total nasal resistance, doubling doses of allergen were sprayed into both nostrils at 15 min intervals until the nasal resistance was doubled. Cumulative doses of allergen that doubled prechallenge nasal resistance, numbers of sneezes and the amounts of nasal secretions were similar before azelastine as well as before and after placebo (cumulative dose, mean, (microgram): 2.3, 4.2 and 2.1 respectively, N.S.). After azelastine, the cumulative dose of allergen was increased (7.3 micrograms), and nasal secretions and the number of sneezes were decreased. The visual analogue scores were similar before and after azelastine as well as before and after the placebo. It is concluded that azelastine reduced the allergen-induced nasal responses.
Eclimed, Institute de Recherche Thérapeutique, Hôpital Universitaire Cochin, Paris.
A
A
Lurie
F
F
Saudubray
J L
JL
Eychenne
A
A
Venot
D
D
de Lauture
J F
JF
Dessanges
A
A
Lockhart
G
G
Strauch
D000328:Adult; D000403:Airway Resistance / Q000187:drug effects; D000485:Allergens / Q000008:administration & dosage / Q000276:immunology*; D005260:Female; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009666:Nose / Q000503:physiopathology; D010793:Phthalazines / Q000494:pharmacology*; D011058:Pollen / Q000276:immunology*; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology* / Q000503:physiopathology; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology* / Q000503:physiopathology; D013997:Time Factors
D000485:Allergens; D006634:Histamine H1 Antagonists; D010793:Phthalazines; C020976:azelastine