Transgenic animal models of cardiovascular disease.
Transgenic experimentation has become a crucial part of hypertension and atherosclerosis research, and is growing more important in several other areas of cardiovascular disease. It has recently made a particular contribution to understanding the role of the renin-angiotensin system in controlling hypertension. The study of blood pressure regulation, cardiac hypertrophy, atherogenesis and thrombosis are also benefiting from the transgenic approach.
Barrett
G
G
Centre for Genome Research, University of Edinburgh, UK.
Mullins
J J
JJ
D000818:Animals; D030801:Animals, Genetically Modified; D016632:Apolipoprotein A-I / Q000378:metabolism; D001161:Arteriosclerosis / Q000235:genetics / Q000503:physiopathology; D001794:Blood Pressure; D006332:Cardiomegaly / Q000235:genetics / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000235:genetics / Q000503:physiopathology*; D008076:Cholesterol, HDL / Q000097:blood; D004195:Disease Models, Animal; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology; D051379:Mice; D008822:Mice, Transgenic; D012083:Renin / Q000235:genetics; D012084:Renin-Angiotensin System / Q000235:genetics
D016632:Apolipoprotein A-I; D008076:Cholesterol, HDL; D012083:Renin