[Experimental data on epithelial factors modulating bronchial reactivity].
A tracheobronchial smooth muscle reactivity study on isolated guinea pig tracheal rings was done. The presence of two different factors active on smooth muscle, an inhibiting one, as well as an activating one was identified. Generated on different pathways, the epithelial derived relaxing factor is a cyclooxygenase dependent prostaglandin, while the activating epithelial factor seems to be a thromboxane derivate.
Hăulică
I
I
Laboratorul de fiziologie, Universitatea de Medicină şi Farmacie Iaşi.
Nechifor
M
M
Ungureanu
D
D
Bălţatu
O
O
Boişteanu
D
D
D000818:Animals; D001685:Biological Factors / Q000502:physiology*; D001980:Bronchi / Q000187:drug effects* / Q000201:enzymology; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D004848:Epithelium / Q000187:drug effects / Q000201:enzymology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects* / Q000201:enzymology; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors; D014132:Trachea / Q000187:drug effects / Q000201:enzymology
D001685:Biological Factors; D016861:Cyclooxygenase Inhibitors; C067763:epithelium-derived inhibitory factor; C056250:epithelium-derived relaxant factor; D013930:Thromboxane-A Synthase
Date experimentale privind factorii epiteliali de modulare a reactivităţii bronşice.