Re-examination of peripheral blood T cell subsets in dysthyroid orbitopathy.
Patients with dysthyroid orbitopathy (DO) were grouped according to a multifactorial assessment of disease severity and the rate of disease progression. Using this system and flow cytometric measurements of T cell subsets in the peripheral blood, a significant increase in the percentage of CD4+ lymphocytes correlated with disease severity in DO patients with progressive disease. These observations are consistent with the hypothesis that the CD4+ peripheral blood T helper cells play a significant role in the progression of DO.
Tyutyunikov
A
A
Department of Ophthalmology, Allegheny General Hospital, Pittsburgh, Pennsylvania.
Raikow
R B
RB
Kennerdell
J S
JS
Kazim
M
M
Dalbow
M H
MH
Scalise
D
D
D000328:Adult; D000368:Aged; D016516:CD4-CD8 Ratio; D015496:CD4-Positive T-Lymphocytes; D005260:Female; D005434:Flow Cytometry; D006111:Graves Disease / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets; D006377:T-Lymphocytes, Helper-Inducer; D050378:T-Lymphocytes, Regulatory