Treatment of acromegaly with dopamine agonists.
This article reviews the current understanding of how dopamine agonists stimulate growth hormone secretion in normal individuals, yet suppress growth hormone secretion in acromegaly patients. Although bromocriptine normalizes growth hormone or somatomedin C hypersecretion in a minority of patients, a significant number of subjects have a clinical response. Side effects of bromocriptine treatment and newer dopamine agonists are discussed. These drugs can be useful medical therapy, either used alone in selected patients or in combination with other therapeutic modalities.
Jaffe
C A
CA
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor.
Barkan
A L
AL
D000172:Acromegaly / Q000188:drug therapy*; D000236:Adenoma / Q000188:drug therapy / Q000473:pathology; D001971:Bromocriptine / Q000494:pharmacology / Q000627:therapeutic use; D015259:Dopamine Agents / Q000494:pharmacology / Q000627:therapeutic use*; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D010903:Pituitary Gland, Anterior / Q000187:drug effects; D010911:Pituitary Neoplasms / Q000188:drug therapy / Q000473:pathology
D015259:Dopamine Agents; D001971:Bromocriptine; D013006:Growth Hormone