Partition and distribution coefficients of aryloxypropanolamine beta-adrenoceptor antagonists.
n-Octanol/water partition and distribution coefficients of fifteen beta-blockers have been measured and the relationships between log P (neutral species), log Pi (fully ionized species) and log D7.4 have been examined. A strict correlation exists among these three parameters, suggesting that the ionization exerts similar effects on the partition behaviour of these drugs.
Recanatini
M
M
Università di Bologna, Dipartimento di Scienze Farmaceutiche, Italia.
D000319:Adrenergic beta-Antagonists / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006863:Hydrogen-Ion Concentration; D000442:Octanols; D011412:Propanolamines / Q000737:chemistry*; D012995:Solubility; D014867:Water
D000319:Adrenergic beta-Antagonists; D000442:Octanols; D011412:Propanolamines; D014867:Water