Decreased striatal D2 dopamine receptors in obese Zucker rats: changes during aging.
The specific binding of [3H]YM-09151-2 was used to investigate the possible differences in age-associated changes in striatal D2 dopamine (DA) receptor properties in genetically obese (fa/fa) Zucker rats and their lean (Fa/?) littermates. The maximal binding sites (Bmax) of D2 DA receptors was found to decline with age in both obese and lean rats; the rate of decline in receptor Bmax was slightly higher in lean than obese rats. However, the Bmax of D2 DA receptor in 6-, 12- and 18-month-old obese rats was significantly lower compared to the age-matched lean rats. These data indicate that obesity decreases the number of striatal D2 DA receptors without affecting the rate at which receptor number decreases with age.
Hamdi
A
A
Laboratory of Neurosciences, Pennington Biomedical Research Center, Baton Rouge, LA 70808.
Porter
J
J
Prasad
C
C
D000375:Aging / Q000378:metabolism*; D000818:Animals; D014150:Antipsychotic Agents / Q000378:metabolism; D001549:Benzamides / Q000378:metabolism; D001835:Body Weight / Q000502:physiology; D007700:Kinetics; D008297:Male; D009765:Obesity / Q000378:metabolism*; D051381:Rats; D011924:Rats, Zucker; D017448:Receptors, Dopamine D2 / Q000378:metabolism*
D014150:Antipsychotic Agents; D001549:Benzamides; D017448:Receptors, Dopamine D2; C030265:nemonapride