Plasma ionized calcium and blood lactate concentrations are inversely associated in human lactic acidosis.
Plasma ionized calcium [Ca++] concentrations are decreased in patients having lactic acidosis. To further investigate this observation, we prospectively studied nine critically ill patients who had lactic acidosis and measured arterial pH, PCO2, [Ca++], lactate, and albumin concentrations. We found a strong association between decreased [Ca++] and increased plasma lactate concentrations (r2 = 0.78, p less than or equal to 0.001). This unexpected association--[Ca++] usually increases with increasing acidosis--might be clinically important and the mechanism deserves further investigation.
Program of Critical Care Medicine, St. Paul's Hospital, Vancouver BC, Canada.
D J
DJ
Cooper
K R
KR
Walley
P M
PM
Dodek
F
F
Rosenberg
J A
JA
Russell
D000140:Acidosis, Lactic / Q000097:blood*; D000328:Adult; D000368:Aged; D002118:Calcium / Q000097:blood*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000097:blood*; D019344:Lactic Acid; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012016:Reference Values; D012044:Regression Analysis; D012709:Serum Albumin / Q000378:metabolism
D007773:Lactates; D012709:Serum Albumin; D019344:Lactic Acid; D002118:Calcium