Predicting antigenic sites on proteins.
The ability to predict antigenic sites on proteins is of major importance for the production of synthetic peptide vaccines and synthetic peptide probes of antibody structure. Many predictive methods, based on various assumptions about the nature of the antigenic response have been proposed and tested. This review will discuss the principles underlying the various approaches to predicting antigenic sites and will attempt to answer the question of how well they work.
Chemical Physics Department, Weizmann Institute of Science, Rehovot, Israel.
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D000595:Amino Acid Sequence; D000939:Epitopes; D011487:Protein Conformation; D011506:Proteins / Q000276:immunology*; D012984:Software
D000939:Epitopes; D011506:Proteins