[Methyldigoxin Reference Standard (Control 881) of National Institute of Hygienic Sciences].
Methyldigoxin was tested for preparation of the "Methyldigoxin Reference Standard (Control 881)". Analytical data obtained were as follows: infrared spectrum 3456, 1738, 1086 cm-1; ultraviolet spectrum lambda max = 219 nm; absorbance E1cm1% (219 nm) = 193.1; water 0.99%; optical rotation [alpha]546.1(20) = +22.5 degrees; thin-layer chromatography and high-performance liquid chromatography indicates two impurities, respectively; quantitative analysis of acetone 3.87%; assay by spectrophotometry 100.3% against Digoxin Reference Standard (Control 802). On the basis of the above results, this material was authorized as the National Institute of the Hygienic Sciences Reference Standard (Control 881).
M
M
Tanaka
M
M
Murai
H
H
Tokunaga
T
T
Kimura
S
S
Okada
D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006077:Government Agencies; D006920:Hygiene; D007564:Japan; D008520:Medigoxin / Q000302:isolation & purification / Q000592:standards*; D010602:Pharmacopoeias as Topic; D013053:Spectrophotometry
D008520:Medigoxin