Elucidation and optimization of the medium constituents controlling antibiotic production by the cyanobacterium Nostoc muscorum.
A study has been made to determine which nutrient factors control antibiotic production by the cyanobacterium, Nostoc muscorum. A two-phase approach was employed using a factorial method to explore the response surface and a steepest ascent method to climb the response surface to the region of the optimum. It was found that nitrate and iron were the factors significantly affecting antibiotic production; 26.4 mM nitrate and 6 microM iron were the optimal concentrations for maximizing antibiotic production by N. muscorum.
School of Applied Biology, Lancashire Polytechnic, Preston, UK.
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Bloor
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England
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D003470:Culture Media; D000458:Cyanobacteria / Q000254:growth & development*; D007700:Kinetics
D000900:Anti-Bacterial Agents; D003470:Culture Media