The neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) alters immune function when given in combination with diethyldithiocarbamate (DDC).
U.S. EPA, Health Effects Research Laboratory, Research Triangle Park, North Carolina 27711.
D B
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Miller
R W
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Luebke
J F
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Reinhard
J P
JP
O'Callaghan
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology*; D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D003342:Corpus Striatum / Q000187:drug effects / Q000201:enzymology; D003345:Corticosterone / Q000097:blood; D004050:Ditiocarb / Q000494:pharmacology*; D004347:Drug Interactions; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012016:Reference Values; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D004050:Ditiocarb; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D014446:Tyrosine 3-Monooxygenase; D003345:Corticosterone