[Preliminary study of cartilage repair with autologous periosteum and fibrin adhesive system].
The potential surgical transplantation with autogenous periosteal grafts and Fibrin Adhesive System (FAS) was attempted in a rabbit model. The grafts were taken from the tibia, transplanted and fixed with FAS to artificial full-thickness (0.4 x 0.3 cm) defect on the femoral condyle. Histologic and ultrastructural findings revealed chondrocyte regeneration in the control, grafted, and graft/FAS treated group at week 6; however, chondrogenesis of the reparative tissue was best demonstrated in the graft/FAS group. At week 12, the interface between the reparative tissue and the surrounding tissue was invisible in the FAS/graft group, as compared with the well-defined interface in the grafted group and the control. The results strongly suggest that FAS-treated periosteal transplant is a potential model for the repair of articular cartilage defects. Although the results are preliminary, all seem promising in the clinical aspects.
Tsai
C L
CL
Department of Orthopaedic Surgery, School of Medicine, National Taiwan University, Taipei, Republic of China.
Liu
T K
TK
Fu
S L
SL
Perng
J H
JH
Lin
A C
AC
D000818:Animals; D002356:Cartilage / Q000601:surgery* / Q000648:ultrastructure; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D008297:Male; D010521:Periosteum / Q000637:transplantation*; D011817:Rabbits; D014182:Transplantation, Autologous
D015718:Fibrin Tissue Adhesive