Differential effect of subthalamic nucleus ablation on dopamine D1 and D2 agonist-induced rotation in 6-hydroxydopamine-lesioned rats.
The effect of unilateral subthalamic nucleus ablation on rotation in response to dopamine D1 and D2 agonists was examined in rats with a unilateral 6-OHDA lesion of the nigrostriatal pathway. Four to five weeks following subthalamic nucleus lesion, D2 agonist-induced rotation was reduced in subthalamic nucleus-lesioned rats relative to sham controls, although no such reduction in D1 agonist-induced circling occurred. However, 1-2 weeks following subthalamic nucleus lesion marked reductions occurred in both D1 and D2 agonist-induced rotation in subthalamic nucleus lesioned rats compared to sham controls. These results suggest that the subthalamic nucleus contributes primarily to the expression of D2-mediated motor behaviors, although ablation of the subthalamic nucleus may induce certain time-dependent compensatory mechanisms in other basal ganglia structures which affect D1-mediated actions.
Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
J J
JJ
Anderson
T N
TN
Chase
T M
TM
Engber
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000494:pharmacology; D000818:Animals; D003342:Corpus Striatum / Q000502:physiology; D015259:Dopamine Agents / Q000494:pharmacology*; D008297:Male; D009434:Neural Pathways / Q000166:cytology / Q000187:drug effects; D016627:Oxidopamine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000187:drug effects*; D017448:Receptors, Dopamine D2 / Q000187:drug effects*; D012399:Rotation; D013239:Stereotyped Behavior / Q000187:drug effects*; D013378:Substantia Nigra / Q000502:physiology; D013787:Thalamic Nuclei / Q000502:physiology*
D015259:Dopamine Agents; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D016627:Oxidopamine