[DNA damage test in forestomach squamous epithelium of F344 rat following oral administration of ethyl acrylate].
The alkaline elution assay were applied for testing DNA damage of forestomach squamous epithelium in male F344 rat after oral administration of ethyl acrylate (EA), a forestomach carcinogen. The animals were starved for 18 hr and then given a single oral dose of EA. No DNA damage were observed by EA at the concentration of 0.1-4.0%. The weights of the forestomach increased with EA dose, reflecting edema and inflammation, but that of glandular stomach did not change with its dose.
K
K
Morimoto
K
K
Tsuji
R
R
Osawa
A
A
Takahashi
D000179:Acrylates / Q000008:administration & dosage / Q000633:toxicity*; D000284:Administration, Oral; D000818:Animals; D004249:DNA Damage; D004848:Epithelium / Q000187:drug effects; D008297:Male; D009152:Mutagenicity Tests / Q000379:methods*; D009153:Mutagens / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344; D013270:Stomach / Q000187:drug effects*
D000179:Acrylates; D009153:Mutagens; C040833:ethyl acrylate