[Neuromyopathy induced by halothane anesthesia and muscle relaxants for status asthmaticus--report of 2 patients].
Two patients with status asthmaticus (a 30-year-old female and a 48-year-old male) who developed flaccid quadriplegia and sensory impairment of glove and stocking type after treatment with halothane, muscle relaxants (pancuronium and vecuronium) and steroid are described. They noted motor and sensory impairment immediately after recovery from control ventilation for treatment of status asthmaticus. Histochemical examinations of biopsied muscle demonstrated the necrosis and regeneration of muscle fibers and small diameters in type I fibers. These results suggested that the involvement of muscle (myopathy) was a consequence of the harmful action of halothane and muscle relaxants together with steroids on muscle fibers with subclinical fragility. The sensory impairment (neuropathy) was considered to have been produced mainly by the halothane together with muscle relaxants and aminoglycosides.
Department of Neurology, Tokai University School of Medicine.
K
K
Akiyama
Y
Y
Shinohara
S
S
Takagi
A
A
Kawana
K
K
Kamio
D000328:Adult; D000758:Anesthesia / Q000009:adverse effects*; D005260:Female; D006221:Halothane / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000139:chemically induced*; D009422:Nervous System Diseases / Q000139:chemically induced*; D010197:Pancuronium / Q000009:adverse effects*; D013224:Status Asthmaticus / Q000188:drug therapy*; D014673:Vecuronium Bromide / Q000009:adverse effects*
D014673:Vecuronium Bromide; D010197:Pancuronium; D006221:Halothane