[Effect of various unsaturated fatty acids on the stability of the erythrocyte membrane in the rat].
In rats restrictive feeding of a half-synthetic diet, with coconut fat as the dietary fat, caused an essential fatty acid deficiency with increased osmotic fragility of erythrocytes against hypotonic saline solutions. A 60% replacement of the coconut fat in the basal diet by pure oleic acid (18:1 n-9) or linoleic acid (18:2 n-6) by 0.6% alpha-linolenic acid (18:3 n-3), eicosatrienoic acid (20:3 n-3) or eicosapentaenoic acid (20:5 n-3) led, in the case of linoleic acid and eicosapentaenoic acid, to a significant decrease in the fragility of rat erythrocytes in comparison with the basal diet. The inefficacy of the alpha-linolenic acid treatment is possibly the consequence of a too low dietary supplementation.
Institut für Ernährungsphysiologie, Technische Universität München, Freising-Weihenstephan, BRD.
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Kirchgessner
D015126:8,11,14-Eicosatrienoic Acid / Q000494:pharmacology; D000818:Animals; D000074263:Coconut Oil; D004041:Dietary Fats / Q000494:pharmacology*; D015118:Eicosapentaenoic Acid / Q000494:pharmacology; D004910:Erythrocyte Membrane / Q000187:drug effects*; D005228:Fatty Acids, Essential / Q000097:blood / Q000172:deficiency*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000494:pharmacology; D008042:Linolenic Acids / Q000494:pharmacology; D008297:Male; D019301:Oleic Acid; D009829:Oleic Acids / Q000494:pharmacology; D009996:Osmotic Fragility / Q000187:drug effects; D010938:Plant Oils / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D017962:alpha-Linolenic Acid
D004041:Dietary Fats; D005228:Fatty Acids, Essential; D005231:Fatty Acids, Unsaturated; D006454:Hemoglobins; D008041:Linoleic Acids; D008042:Linolenic Acids; D009829:Oleic Acids; D010938:Plant Oils; D017962:alpha-Linolenic Acid; D019301:Oleic Acid; D019787:Linoleic Acid; D015118:Eicosapentaenoic Acid; D015126:8,11,14-Eicosatrienoic Acid; D000074263:Coconut Oil
Einfluss verschiedener ungesättigter Fettsäuren auf die Stabilität der Erythrozytenmembran bei der Ratte.