Molecular design of cholera vaccines.
Cholera is still a serious public health problem in developing countries, particularly those in tropical regions. This has stimulated considerable research into the molecular analysis of pathogenesis resulting in the identification of a number of critical components required for both colonization of the gut mucosa and the disease symptoms. These components are the targets for rational molecular approaches to vaccine development.
Manning
P A
PA
Department of Microbiology and Immunology, University of Adelaide, South Australia.
D001426:Bacterial Proteins / Q000276:immunology; D002771:Cholera / Q000517:prevention & control; D002772:Cholera Toxin / Q000276:immunology*; D022121:Cholera Vaccines; D003906:Developing Countries; D015195:Drug Design; D010861:Fimbriae, Bacterial / Q000276:immunology; D006801:Humans; D008070:Lipopolysaccharides / Q000276:immunology; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated; D014614:Vaccines, Synthetic; D014734:Vibrio cholerae / Q000235:genetics / Q000276:immunology
D001426:Bacterial Proteins; D022121:Cholera Vaccines; D008070:Lipopolysaccharides; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated; D014614:Vaccines, Synthetic; D002772:Cholera Toxin