Low-dose inhalation nitric oxide in persistent pulmonary hypertension of the newborn.
We studied the effects of inhaled nitric oxide (NO) in 9 newborn infants with severe persistent pulmonary hypertension (PPHN) who were candidates for extracorporeal membrane oxygenation treatment. With low doses of NO (10-20 ppm) all showed rapid improvement in oxygenation without reduction of systemic blood pressure. In 6 infants treated with inhaled NO for 24 h, clinical improvement was sustained at 6 ppm.
Department of Pediatrics, Children's Hospital, Denver, Colorado 80218-1088.
J P
JP
Kinsella
S R
SR
Neish
E
E
Shaffer
S H
SH
Abman
D000280:Administration, Inhalation; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D015199:Extracorporeal Membrane Oxygenation; D006801:Humans; D007231:Infant, Newborn; D008706:Methemoglobin / Q000032:analysis; D009569:Nitric Oxide / Q000008:administration & dosage / Q000627:therapeutic use*; D010100:Oxygen / Q000097:blood; D010547:Persistent Fetal Circulation Syndrome / Q000097:blood / Q000188:drug therapy*
D002245:Carbon Dioxide; D009569:Nitric Oxide; D008706:Methemoglobin; D010100:Oxygen