[Histochemical and histologic examination of kidney from white rats after experimental administration of dexamethasone].
Kidneys of the rats which had been intragastrically administered Dexamethasone (10 mg/kg), were examined. Observations were carried out after a single and twice repeated application of the preparation, as well as after 7 days of everyday administration. It was found, on the basis of histological and histochemical observations (reaction to alkaline phosphatase activity, reaction to acid phosphatase activity, PAS-method staining), that both single and twice administration of Dexamethasone do not cause the damage of the kidney parenchyma, whereas after 7 days of everyday application of the preparation irreversible changes can be observed.
Katedra i Zakład Histologii i Embriologii z Pracownia Cytologii Doświadczalnej. Akademia Medyczna w Lublinie.
K
K
Czerny
E
E
Kifer-Wysocka
J
J
Romanowska-Sarlej
E
E
Kurnicka
D000284:Administration, Oral; D000818:Animals; D003907:Dexamethasone / Q000633:toxicity*; D004334:Drug Administration Schedule; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D003907:Dexamethasone
Badania histochemiczne i histologiczne nerki szczura białego po doświadczalnym podawaniu dexamethasonu.