The effect of anti-adhesion molecule antibody on the development of collagen-induced arthritis.
In order to study how inflammatory cells including autoimmune lymphocytes interact with each other to develop collagen-induced arthritis (CIA), we injected monoclonal antibodies against mouse LFA-1 and ICAM-1 into DBA/1 mice immunized with type II collagen (CII). Both antibodies suppressed the development of CIA. These antibodies showed no effect on anti-CII antibody response, although they both significantly suppressed DTH response. It was suggested that anti-adhesion molecule antibodies suppress CIA mainly through their effect on cell-mediated immunity, without affecting humoral immunity under the conditions used.
Department of Biochemistry, Kumamoto University Medical School, Japan.
K
K
Kakimoto
T
T
Nakamura
K
K
Ishii
T
T
Takashi
H
H
Iigou
H
H
Yagita
K
K
Okumura
K
K
Onoue
D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D001172:Arthritis, Rheumatoid / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D015815:Cell Adhesion Molecules / Q000276:immunology*; D002478:Cells, Cultured / Q000187:drug effects; D003094:Collagen / Q000008:administration & dosage / Q000276:immunology*; D004195:Disease Models, Animal; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects; D018799:Intercellular Adhesion Molecule-1; D008198:Lymph Nodes / Q000166:cytology; D016169:Lymphocyte Function-Associated Antigen-1 / Q000276:immunology*; D051379:Mice; D008811:Mice, Inbred DBA
D000911:Antibodies, Monoclonal; D015815:Cell Adhesion Molecules; D016169:Lymphocyte Function-Associated Antigen-1; D018799:Intercellular Adhesion Molecule-1; D003094:Collagen