Potentiation by m-cresol on transepithelial sodium transport across frog skin induced by insulin.
1. In this study we found that insulin mixed with m-cresol, normally used as pharmaceutical preparation, shows an earlier and larger stimulating effect on transepithelial sodium transport than insulin alone. 2. The action displayed by the m-cresol seems to be specific for insulin because m-cresol mixed with ADH, a hormone known to stimulate sodium transport, failed to show the potentiation seen for insulin. 3. It is proposed that m-cresol could facilitate the interaction with its receptor by modifying the insulin molecule. 4. This finding could be of biological and pharmacological importance.
Pharmaco-Biological Department, University of Bari, Italy.
E
E
Gallucci
S
S
Micelli
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D003408:Cresols / Q000494:pharmacology*; D004357:Drug Synergism; D004848:Epithelium / Q000378:metabolism; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology*; D011893:Rana esculenta; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012869:Skin Absorption / Q000187:drug effects; D012964:Sodium / Q000493:pharmacokinetics*
D003408:Cresols; D007328:Insulin; C032538:4-cresol; D012964:Sodium