Increased rates of punished responding produced by buspirone-like compounds in rats.
Buspirone has been reported to have effects on punished responding in rats which are considerably smaller and less reliable than those produced by benzodiazepines. A recent study, however, found that buspirone and ipsapirone increased operant responding suppressed by a stimulus which preceded unavoidable shock, suggesting that conditioned emotional response protocols may be more sensitive than punishment procedures. This hypothesis was not supported by the results of the present study. The food-reinforced lever pressing of rats was maintained by a multiple VI schedule with punished and unpunished components. The experimental parameters were similar to those used in the previous conditioned emotional response study. The benzodiazepines, chlordiazepoxide and clorazepate, as well as buspirone (at one dose) and ipsapirone (at several doses), increased rates of punished responding. The 5-hydroxytryptamine-1A receptor ligands 8-hydroxy-2-(di-n-propylamino)tetralin and MDL 73005EF did not reliably produce similar effects, although increased rates of punished responding were seen in some animals. Haloperidol, imipramine and idazoxan did not increase punished response rates. Although the increases in punished responding produced by buspirone were smaller than those produced by chlordiazepoxide and clorazepate, the effect of ipsapirone was quantitatively similar to that of the benzodiazepines.
Synthélabo Recherche (L.E.R.S), Bagneux, France.
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Sanger
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D002065:Buspirone / Q000494:pharmacology*; D002707:Chlordiazepoxide / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects*; D004147:Dioxins / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006220:Haloperidol / Q000494:pharmacology; D007275:Injections, Intravenous; D008297:Male; D011678:Punishment; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects; D013141:Spiro Compounds / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D004147:Dioxins; D011743:Pyrimidines; D011985:Receptors, Serotonin; D013141:Spiro Compounds; C063249:binospirone mesylate; C043077:ipsapirone; D002707:Chlordiazepoxide; D006220:Haloperidol; D002065:Buspirone