T lymphocyte subsets in chronic uremic patients treated with maintenance hemodialysis.
Blood T lymphocyte subsets have been studied using monoclonal antibodies in 10 chronic uremic patients treated with maintenance hemodialysis. Both total T lymphocytes identified by the antibody OKT3, and the helper-inducer T lymphocyte subset identified by the antibody OKT4 were found to be significantly lower than normal. The cytotoxic-suppressor T cell subset was only moderately, even if significantly reduced, so that the T4/T8 ratio in uremic patients was significantly lower than normal. These data provide an additional contribution to the interpretation of immunological and hematological deficiencies observed in chronic uremia.
Istituto Scientifico di Medicina Interna (ISMI), University of Genoa, Italy.
L
L
Morra
G A
GA
Ponassi
G
G
Gurreri
F
F
Moccia
G S
GS
Mela
G
G
Bessone
D000328:Adult; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000276:immunology*; D007962:Leukocytes; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014511:Uremia / Q000276:immunology*