Optimal drug and behavior therapy for treatment-refractory institutionalized schizophrenics.
Institutionalized persons with a deteriorating form of schizophrenia that was refractory to neuroleptic medication were titrated downward in their haloperidol dose. Based on ratings of their clinical status, an optimal dose was reached that was an average 66 percent reduction from their initial levels. Patients then participated in a personalized, intensive behavior therapy program to remediate their extreme, persisting deficits and disturbances in behavior.
UCLA School of Medicine.
T G
TG
Kuehnel
R P
RP
Liberman
B D
BD
Marshall
L
L
Bowen
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001521:Behavior Therapy; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D007326:Institutionalization; D012559:Schizophrenia / Q000534:rehabilitation*; D012565:Schizophrenic Psychology
D014150:Antipsychotic Agents; D006220:Haloperidol