Adaptive changes in total pyruvate dehydrogenase activity in lipogenic tissues of rats fed high-sucrose or high-fat diets.
1. Pyruvate dehydrogenase complex (PDC) activity was measured in several tissues of rats fed for 7 or 15 days on control, or high-sucrose or high-fat diets. 2. Total activity in adipose tissue increased in the three groups 3-4 fold as compared with chow-fed animals in the first week. Total activity was 60% lower in rats fed the diet containing 22% corn oil for 2 weeks. 3. Hepatic total and PDCa activities were 50-80% higher in rats fed the sucrose diet for 7 or 15 days and decreased 30-40% in those fed on the high-fat diet for 2 weeks.
Instituto de Medicina Experimental, Facultad de Medicina, Universidad Central de Venezuela, Caracas.
L A
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Da Silva
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De Marcucci
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Carmona
D000222:Adaptation, Physiological / Q000502:physiology*; D000273:Adipose Tissue / Q000187:drug effects / Q000201:enzymology*; D000818:Animals; D004032:Diet; D004041:Dietary Fats / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013395:Sucrose / Q000494:pharmacology*
D004041:Dietary Fats; D011768:Pyruvate Dehydrogenase Complex; D013395:Sucrose