Abnormalities in amino acid neurotransmitters in discrete brain regions of genetically dystonic hamsters.
The concentrations of 11 amino acids, including the neurotransmitters gamma-aminobutyric acid, glutamate, aspartate, glycine, and taurine, were determined by HPLC in 12 brain regions of genetically dystonic (dtSZ) hamsters and age-matched nondystonic controls. Since dystonia in mutant dtSZ hamsters is transient and disappears after about 70 days of age, amino acids were determined at the age of maximum severity of dystonia (30-40 days) and after disappearance of the disease, to examine which neurochemical changes were related to dystonia. In dtSZ hamsters with the maximum severity of dystonia, significant changes in concentrations of the neurotransmitters gamma-aminobutyric acid, glutamate, aspartate, and taurine were found in several regions involved in motor functions, e.g., cerebellum, thalamus, and corpus striatum. Most of these changes were not permanent but disappeared in parallel with dystonia, implicating a causal relationship between altered aminoacidergic neurotransmission and dystonia in mutant dtSZ hamsters.
Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, F.R.G.
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Löscher
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Hörstermann
D000818:Animals; D001224:Aspartic Acid / Q000032:analysis / Q000378:metabolism; D002531:Cerebellum / Q000737:chemistry* / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003342:Corpus Striatum / Q000737:chemistry* / Q000378:metabolism; D006224:Cricetinae / Q000235:genetics*; D004421:Dystonia / Q000235:genetics* / Q000378:metabolism*; D005971:Glutamates / Q000032:analysis / Q000378:metabolism; D005998:Glycine / Q000032:analysis / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000032:analysis* / Q000378:metabolism; D013654:Taurine / Q000032:analysis / Q000378:metabolism; D013788:Thalamus / Q000737:chemistry* / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000032:analysis / Q000378:metabolism
D005971:Glutamates; D018377:Neurotransmitter Agents; D013654:Taurine; D001224:Aspartic Acid; D005680:gamma-Aminobutyric Acid; D005998:Glycine