Evolution of phenotypic memory T cells in HIV-1 infected infants and children.
Infants are reported to be devoid of memory T cells at birth but acquired them with time. A cross-sectional study of peripheral blood mononuclear cells from HIV-infected and uninfected infants and children that bear the CD4R0 antigen was undertaken to describe the development of memory T cells. Linear regression lines derived from the data revealed increasing percentages of memory CD4 and CD8 cells in the uninfected children. Memory CD4 cells in the infected children were detected at a frequency equal to or greater than that seen in uninfected children until 6 months of age but subsequently declined with age. In contrast, memory CD8 cells were found to be significantly increased in HIV-infected children early in life with a rate of increase similar to that seen in the uninfected population. This increase in memory CD8 cells may facilitate the early diagnosis of HIV infection.
Borkowsky
W
W
Department of Pediatrics, New York University Medical Center, Bellevue Hospital Center, New York 10016.
Moore
T
T
Krasinski
K
K
Ajuang-Simbiri
K O
KO
Holzman
R
R
D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016827:CD8 Antigens / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory / Q000235:genetics; D007223:Infant; D007231:Infant, Newborn; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology*
D016827:CD8 Antigens