Recombinant haemoglobin in the development of red-blood-cell substitutes.
Increasing concern over viral contamination of blood is spurring the development of a blood substitute which can effectively replace the oxygen-carrying capabilities of transfused erythrocytes. Solutions of chemically modified haemoglobin represent one option being evaluated for this role. More recently, recombinant-DNA techniques have enabled production of human haemoglobin in host expression systems, and progress is being made towards the creation of a genetically engineered molecule incorporating the properties required of a blood substitute.
Ogden
J E
JE
Delta Biotechnology Ltd, Nottingham, UK.
D000818:Animals; D001802:Blood Substitutes; D005818:Genetic Engineering; D006454:Hemoglobins / Q000235:genetics*; D006801:Humans; D011994:Recombinant Proteins / Q000235:genetics
D001802:Blood Substitutes; D006454:Hemoglobins; D011994:Recombinant Proteins