Differential effects of CD4+ and CD8+ cells in acute, systemic murine candidosis.
Monoclonal antibody (mAb) depletion was used to assess contributions of CD4+ and CD8+ cells in resistance to systemic murine Candida albicans infection. Depletion of CD8+ cells did not influence either survival or mean survival time (MST); however, depletion of CD4+ cells significantly enhanced both survival and MST. Combined depletion of both CD4+ and CD8+ cells significantly lengthened the MST but did not enhance survival. A protective influence of CD8+ cells could be deduced but, to be manifested, required depletion of an overshadowing immunopathologic CD4+ response.
Coker
L A
LA
Department of Microbiology, College of Liberal Arts, University of Tennessee, Knoxville 37996-0845.
Mercadal
C M
CM
Rouse
B T
BT
Moore
R N
RN
D000208:Acute Disease; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D016827:CD8 Antigens / Q000032:analysis*; D002177:Candidiasis / Q000276:immunology* / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D007113:Immunity, Innate; D051379:Mice; D008807:Mice, Inbred BALB C; D013601:T-Lymphocytes / Q000276:immunology*
D016827:CD8 Antigens