[Changes in the thyroid and other internal organs of experimental animals exposed to a drinking regimen with a high nitrate content].
A 3-month experiment was carried out with 24 sexually mature white male rats, approximately the same age, "Wistar" breed, distributed in control and experimental groups, each of 12 rats. The experimental group received "ad libitum" drinking water with average nitrate content 104.3 +/- 2.5 mg/l, and the control group--drinking water with nitrate content 12.0 +/- 2.0 mg/l. Both groups received standard food special After the expire of the experimental time the animals were killed and some organs--thyroid gland, liver, kidneys, spleen and brain were macro- and microscopically examined. There were microscopic changes in the thyroid gland of the experimental group of animals, expressed in thyroid activity with rearrangement of the colloid and formation of vacuoles in the periphery of the folliculi. In the liver and kidneys parenchymatous granular dystrophy was observed.
Gatseva
P
P
Marinova
S
S
Vŭrtigova
L
L
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000473:pathology; D002031:Bulgaria; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D009566:Nitrates / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D013961:Thyroid Gland / Q000187:drug effects* / Q000473:pathology; D013997:Time Factors; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D014881:Water Supply
D009566:Nitrates; D014874:Water Pollutants, Chemical
Promeni v shtitovidnata zhleza i drugi vŭtreshni organi na opitni zhivotni, podlozheni na piteen rezhim s visoko nitratno sŭdŭrzhanie.