Clinical and non-invasive evaluation of 12% ammonium lactate emulsion for the treatment of dry skin in atopic and non-atopic subjects.
Clinical dryness of the leg skin is a common problem among dermatological patients. The efficacy and safety of 12% ammonium lactate emulsion (Keratisdin) for the treatment of dry skin on the legs of atopic and non-atopic subjects has been assessed by clinical criteria and by five different non-invasive methods. These methods measure biophysical parameters such as electrical capacitance of stratum corneum, skin surface lipids, transepidermal water loss (TEWL), skin surface topography (scanning electron microscopy and image analysis) as well as the biomechanical properties of the skin. Treatment with the test emulsion significantly reduced the severity scores for dryness, desquamation and pruritus when measured 15 days later. All patients tested showed a significant increase in electrical capacitance, skin surface lipids, extensibility and firmness of the skin, and an improvement in the skin barrier function and skin surface topography. This study showed that non-invasive techniques are excellent complementary tools in clinical studies.
Vilaplana
J
J
Department of Dermatology, University of Barcelona, St. Joan Hospital, Reus, Spain.
Coll
J
J
Trullás
C
C
Azón
A
A
Pelejero
C
C
D000328:Adult; D001696:Biomechanical Phenomena; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D004553:Electric Conductivity / Q000187:drug effects; D004655:Emulsions; D004817:Epidermis / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006801:Humans; D007773:Lactates / Q000494:pharmacology / Q000627:therapeutic use*; D019344:Lactic Acid; D007868:Leg Dermatoses / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D050356:Lipid Metabolism; D008297:Male; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D012720:Severity of Illness Index; D014870:Water Loss, Insensible / Q000187:drug effects
D004655:Emulsions; D007773:Lactates; D019344:Lactic Acid