Resistance of hippocampal CA-1 noradrenergic fibers to five minutes of transient cerebral ischemia in the gerbil.
We examined changes in the tyrosine hydroxylase (TH)-immunoreactive fibers following 5 min of cerebral ischemia in gerbils using an immunohistochemical method 1, 3 and 30 days after ischemia. Almost all CA-1 pyramidal neurons were lost 3 days after ischemia, whereas noradrenergic fibers were maintained 30 days after ischemia. The present study demonstrated that TH-immunoreactive fibers and cells were resistant to transient ischemia, and that there was no sprouting or hyperactivity in noradrenergic systems after ischemia.
Tomioka
C
C
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
Nishioka
K
K
Kogure
K
K
D000320:Adrenergic Fibers / Q000502:physiology*; D000818:Animals; D004299:Dopamine beta-Hydroxylase / Q000276:immunology / Q000378:metabolism; D005849:Gerbillinae; D006624:Hippocampus / Q000473:pathology*; D007150:Immunohistochemistry; D002546:Ischemic Attack, Transient / Q000473:pathology*; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D011712:Pyramidal Tracts / Q000473:pathology; D014446:Tyrosine 3-Monooxygenase / Q000276:immunology / Q000378:metabolism
D014446:Tyrosine 3-Monooxygenase; D004299:Dopamine beta-Hydroxylase; D009638:Norepinephrine