[Clinical applications of ion-sensor].
The coulometric measurement technique offers a rapid, accurate and precise method for measuring iron in liquid samples. It is well-known that analytical interferences common to colorimetric methods essentially do not exist in this procedure. However, this study shows that various drugs, such as chondroitin iron sulfate, deferoxamine mesylate, and salazosulfapyridine have strongly positive effects on the most contemporary determination of serum iron. The study of the analytical interference of drugs is important for precise and accurate measurement of desirable or undesirable pharmacological effects. New drugs and new methods should be systematically studied in this manner.
Sekiguchi
M
M
Department of Clinical Laboratory, Nihon University Itabashi Hospital, Tokyo.
D015374:Biosensing Techniques; D002809:Chondroitin Sulfates / Q000493:pharmacokinetics; D003124:Colorimetry; D003676:Deferoxamine / Q000493:pharmacokinetics; D006801:Humans; D007477:Ions; D007501:Iron / Q000097:blood*; D012460:Sulfasalazine / Q000493:pharmacokinetics
D007477:Ions; D012460:Sulfasalazine; D002809:Chondroitin Sulfates; D007501:Iron; D003676:Deferoxamine