Biopharmacological data and high-performance liquid chromatographic analysis of 1,4-benzodiazepines in biological fluids: a review.
A review with 123 references on the analysis of 1,4-benzodiazepines in biological samples using HPLC is presented. Some important physico-chemical and biopharmacological data for the development of analytical methods are collected. Different methods of sample pretreatment, chromatographic conditions and detection systems are discussed.
Berrueta
L A
LA
Departamento de Química Analítica, Facultad de Ciencias, Universidad del Paías Vasco, Bilbao, Spain.
Gallo
B
B
Vicente
F
F
D014151:Anti-Anxiety Agents / Q000032:analysis* / Q000097:blood / Q000378:metabolism / Q000652:urine; D001569:Benzodiazepines; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003975:Diazepam / Q000032:analysis; D005479:Flurazepam / Q000032:analysis; D008140:Lorazepam / Q000031:analogs & derivatives / Q000032:analysis; D010084:Oxidation-Reduction; D014229:Triazolam / Q000032:analysis
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D014229:Triazolam; C023842:lormetazepam; D005479:Flurazepam; D008140:Lorazepam; D003975:Diazepam