The impact of human T-lymphotrophic virus type I/II infection on the prognosis of sexually acquired cases of acquired immunodeficiency syndrome.
Twenty (18%) of 111 Peruvian men with sexually acquired human immunodeficiency virus infection were found also to be infected with human T-lymphotrophic virus type I or II in a retrospective study. At the time of data evaluation, 75 patients had reached Centers for Disease Control stage IV (clinical acquired immunodeficiency syndrome) and had not received antiviral medication; mortality in this group was 63.3% (38/60) among patients infected with human immunodeficiency virus alone and 80% (12/15) in the dually infected group. Of the 50 patients who had died, survival time from onset of stage IV to death was shorter in the dually infected group (5.02 +/- 3.27 months) than in those with human immunodeficiency virus infection alone (10.07 +/- 4.42 months). In Peru, sexually acquired human immunodeficiency virus infection in men is often accompanied by human T-lymphotrophic virus type I/II infection, and dual retrovirus infection is associated with a shorter survival after onset of clinical acquired immunodeficiency syndrome.
Gotuzzo
E
E
Alexander Von Humboldt Institute of Tropical Medicine, Cayetano Heredia Peruvian University, Lima, Peru.
Escamilla
J
J
Phillips
I A
IA
Sánchez
J
J
Wignall
F S
FS
Antigoni
J
J
D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology* / Q000401:mortality / Q000473:pathology; D000328:Adult; D006800:Deltaretrovirus Infections / Q000150:complications*; D006679:HIV Seropositivity / Q000150:complications*; D015368:Human T-lymphotropic virus 1; D015367:Human T-lymphotropic virus 2; D006801:Humans; D008297:Male; D010568:Peru / Q000453:epidemiology; D011379:Prognosis; D012189:Retrospective Studies; D012747:Sexual Partners; D015996:Survival Rate