DLX2 (TES1), a homeobox gene of the Distal-less family, assigned to conserved regions on human and mouse chromosomes 2.
Dlx-2 (also called Tes-1), a mammalian member of the Distal-less family of homeobox genes, is expressed during murine fetal development in spatially restricted domains of the forebrain. Searching for a candidate neurological mutation that might involve this gene, we have assigned the human and mouse loci to regions of conserved synteny on human chromosome 2, region cen--q33, and mouse chromosome 2 by Southern analysis of somatic cell hybrid lines. An EcoRI dimorphism, discovered in common inbred laboratory strains, was used for recombinant inbred strain mapping. The results place Dlx-2/Tes-1 near the Hox-4 cluster on mouse chromosome 2.
Howard Hughes Medical Institute, Stanford University Medical Center, California 94305.
T
T
Ozçelik
M H
MH
Porteus
J L
JL
Rubenstein
U
U
Francke
D000818:Animals; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002875:Chromosomes; D002877:Chromosomes, Human; D004247:DNA; D005801:Genes, Homeobox; D008040:Genetic Linkage; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009154:Mutation; D011110:Polymorphism, Genetic
D004247:DNA