Haemolytic action of N-alkylpolymethylenediamines.
The haemolytic action of various N-alkyl derivatives (lauryl; C12H25-, myristyl; C14H29-, palmityl; C16H33-) of 1,3-diaminopropane, 1,4-diaminobutane, 1,5-diaminopentate, 1,6-diaminohexane, 1,7-diaminoheptane, 1,8-diaminooctane was examined using rabbit red blood cells. The activities of the various derivatives were compared with those of antiplaque agents commonly used as mouthwashes; cetylpyridinium chloride (CP) and chlorhexidine acetate (CH). The haemolytic activities of these agents were dependent on the length of the N-alkyl chain, whereas the number of methylene groups between the nitrogen atoms had little effect. The order of potency was CP, N-palmityl derivatives, N-myristyl derivatives greater than N-lauryl derivatives greater than CH which was similar to the order of the antiplaque effect evaluated in-vitro.
School of Pharmacy, Hokuriku University, Kanazawa, Japan.
E
E
Miyamoto
Y
Y
Murata
S
S
Kawashima
M
M
Ueda
D000818:Animals; D002594:Cetylpyridinium / Q000494:pharmacology; D002710:Chlorhexidine / Q000494:pharmacology; D003773:Dental Plaque / Q000517:prevention & control; D003959:Diamines / Q000494:pharmacology*; D006461:Hemolysis / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D009067:Mouthwashes; D011817:Rabbits
D003959:Diamines; D009067:Mouthwashes; D002594:Cetylpyridinium; D002710:Chlorhexidine