[The effect of propranolol and flusoxolol on the lysosomal enzyme activity of the rat ventricular myocardium].
The nonselective beta-blocker propranolol and the selective beta 1-adrenoblocker flusoxolol were tested for their effects on the activities of acid phosphatase, acid DNAase, cathepsin D, beta-glucosidase and beta-galactosidase in intact rat ventricular myocardial homogenates. The two drugs were found to have the most noticeable effect on the activity of three enzymes under study: acid phosphatase, beta-glucosidase and beta-galactosidase. They were able to stabilize lysosomal membranes during long-term homogenate preincubation at 37 degrees S. It is suggested that the mechanism of action of the drugs on intact rat ventricular myocardial lysosomes under the conditions of the study involves the binding of both propranolol and flusoxolol to beta-adrenoceptors on the lysosomes.
Sysoliatina
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D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004795:Enzyme Stability / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D006352:Heart Ventricles / Q000187:drug effects / Q000201:enzymology; D066298:In Vitro Techniques; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D050198:Phenoxypropanolamines; D011412:Propanolamines / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013696:Temperature
D000319:Adrenergic beta-Antagonists; D050198:Phenoxypropanolamines; D011412:Propanolamines; C045426:flusoxolol; D011433:Propranolol
Vliianie propranolola i fluzoksolola na aktivnost' lizosomal'nykh fermentov miokarda zheludochkov krys.