[The antidystrophic effect of the action of beta-adrenoblockaders in local damage to the nervous system].
It has been established that the lesion of the sciatic nerve, accompanied by a disturbance of normal neurotrophic provision of a kidney as a result of coming to the organ of the perverted nervous stimuli (by the neuro-conductive path through sympathetic nerves and by participation of the hypothalamus--hypophysis--peripheral glands system), leads to disturbance of functioning of mineral-corticoid receptors of kidneys. It has been also established that simultaneous pharmacological blockade of neuro-conductive and humoral pathways of transmission to the kidney of pathological stimuli from the central stump of the cut sciatic nerve prevents the development of trophic organ disturbances, tested by the state of the kidney mineral-corticoid receptor apparatus, while pharmacological stimulation of sympathetic nervous system leads to the greater disturbance of aldosterone reception by the cells of kidney channels. A valid conclusion can be made that propranolol is a substance, which may weaken possible non-adequate reactions of peripheral tissues to the action of physiologically active substances during the development of the consequences of the lesion of the nervous system and thus to prevent the development of neurogenic dystrophies.
Azhipa
Ia I
IaI
Akimov
Iu A
IuA
Grishchenko
A I
AI
Rodionov
A A
AA
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000450:Aldosterone / Q000378:metabolism; D000818:Animals; D004353:Drug Evaluation, Preclinical; D007668:Kidney / Q000187:drug effects / Q000294:innervation / Q000378:metabolism; D007980:Levodopa / Q000008:administration & dosage; D008297:Male; D008901:Mineralocorticoids / Q000502:physiology; D011433:Propranolol / Q000008:administration & dosage; D051381:Rats; D018161:Receptors, Mineralocorticoid; D011987:Receptors, Steroid / Q000187:drug effects / Q000502:physiology; D012019:Reflex Sympathetic Dystrophy / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D012584:Sciatic Nerve / Q000293:injuries; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000293:injuries; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D008901:Mineralocorticoids; D018161:Receptors, Mineralocorticoid; D011987:Receptors, Steroid; D007980:Levodopa; D000450:Aldosterone; D011433:Propranolol
O protivodistroficheskom éffekte deĭstviia beta-adrenoblokatorov pri lokal'nom povrezhdenii nervnoĭ sistemy.