Protein-catalysed protein folding.
A number of proteins, termed chaperonins, have been identified as part of the mechanism of folding other proteins into their biologically active forms. The role of chaperonins appears to be twofold--to prevent illegitimate interactions with other proteins and to facilitate folding, possibly through an energy-dependent, catalytic function. Controlled overexpression of chaperonins may be of therapeutic value in manipulating human immune response and rescuing certain inherited human mutations.
Horwich
A L
AL
Department of Human Genetics, Yale University School of Medicine, New Haven, CT 06510.
Neupert
W
W
Hartl
F U
FU
D018834:Chaperonin 60; D018833:Chaperonins; D006360:Heat-Shock Proteins / Q000502:physiology; D011487:Protein Conformation; D011506:Proteins / Q000502:physiology*
D018834:Chaperonin 60; D006360:Heat-Shock Proteins; D011506:Proteins; D018833:Chaperonins