Immunologic characteristics of fibrillary glomerulonephritis.
IgG and IgA immune complexes, mononuclear phagocytic system function, interleukin-2 (IL-2) production by peripheral blood lymphocytes (PBL), serum-soluble IL-2 receptors, tumor necrosis factor, beta 2-microglobulin and IL-1 beta, HLA-DNA polymorphisms, immuno-isoelectrofocusing, phenotype of PBL, lymphocyte cytotoxicity, activation of lymphokine-activated killer cells and natural killer cell activity were evaluated in 8 patients with tubular/fibrillary glomerulonephritis (GN). No common serologic, immunologic or immunogenetic features suggestive of plasma cell dyscrasias were found. No elements to state whether these GNs represent a new entity or just atypical forms of known GN were found.
Institute of Nephro-Urology, San Giovanni Hospital, Italy.
C
C
Rollino
D
D
Roccatello
G
G
Mazzucco
M
M
Boccadoro
M
M
Massaia
S
S
Battaglio
P
P
Omedé
A
A
Amoroso
G
G
Mazzola
G
G
Aimo
D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D002648:Child; D003602:Cytotoxicity, Immunologic; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology*; D006681:HLA-D Antigens / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007376:Interleukin-2 / Q000096:biosynthesis; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D015375:Receptors, Interleukin-2 / Q000378:metabolism; D012995:Solubility
D015703:Antigens, CD; D006681:HLA-D Antigens; D007376:Interleukin-2; D015375:Receptors, Interleukin-2