Processed MHC class I alloantigen as the stimulus for CD4+ T-cell dependent antibody-mediated graft rejection.
The traditional view of graft rejection is one of direct recognition of allogeneic MHC molecules by effector T cells, the phenotype of which may be predicted by the nature of the MHC disparity. In this article, Andrew Bradley and colleagues discuss recent evidence that suggests this view may be an oversimplification, and argue that additional effector mechanisms, such as alloantibody, need to be reconsidered.
Bradley
J A
JA
University Department of Surgery, Glasgow.
Mowat
A M
AM
Bolton
E M
EM
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D006084:Graft Rejection / Q000276:immunology*; D006649:Histocompatibility Antigens / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D016219:Immunotherapy, Adoptive; D007518:Isoantibodies / Q000276:immunology*; D007519:Isoantigens / Q000276:immunology*; D016030:Kidney Transplantation / Q000276:immunology; D008212:Lymphocyte Depletion; D051379:Mice; D008954:Models, Biological; D051381:Rats; D016038:Skin Transplantation / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014184:Transplantation, Homologous / Q000276:immunology
D006649:Histocompatibility Antigens; D015395:Histocompatibility Antigens Class I; D007518:Isoantibodies; D007519:Isoantigens; C038353:histocompatibility antigens RT, rat