Anti-inflammatory activity of oleanolic acid in rats and mice.
Oleanolic acid displayed anti-inflammatory activity in carrageenan and dextran-induced oedema in rats. It elicited marked anti-arthritic action in adjuvant-induced polyarthritis in rats and mice and in formaldehyde-induced arthritis in rats. Oleanolic acid checked the inflammation-induced increased serum transaminase levels. It reduced exudate volume and inhibited leucocyte infiltration in carrageenan-induced pleurisy in rats. It is devoid of any analgesic, antipyretic or ulcerogenic action. Oleanolic acid did not affect the parturition time in pregnant rats or castor oil-induced diarrhoea in rats. Oral LD50 was found to be greater than 2 g kg-1 in mice and rats.
Singh
G B
GB
Pharmacology Department, Regional Research Laboratory, Jammu-Tawi, India.
Singh
S
S
Bani
S
S
Gupta
B D
BD
Banerjee
S K
SK
D000315:Adrenalectomy; D000818:Animals; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000633:toxicity; D001169:Arthritis, Experimental / Q000188:drug therapy; D001522:Behavior, Animal / Q000187:drug effects; D002351:Carrageenan; D003967:Diarrhea / Q000139:chemically induced / Q000517:prevention & control; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D005557:Formaldehyde; D003368:Gossypium; D007743:Labor, Obstetric / Q000187:drug effects; D008297:Male; D051379:Mice; D009828:Oleanolic Acid / Q000494:pharmacology* / Q000633:toxicity; D010998:Pleurisy / Q000139:chemically induced / Q000517:prevention & control; D011247:Pregnancy; D051381:Rats; D012639:Seeds / Q000737:chemistry; D013276:Stomach Ulcer / Q000139:chemically induced; D000637:Transaminases / Q000097:blood
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005557:Formaldehyde; D009828:Oleanolic Acid; D002351:Carrageenan; D000637:Transaminases