Toremifene resistance in a rat mammary tumour model.
The effect of Toremifene on cell growth in vitro was tested on the R3230AC rat mammary adenocarcinoma as model. Toremifene differed from Tamoxifen in that it did not induce resistance; some cross-resistance was observed in Tamoxifen tolerant tumour cell lines. Toremifene does not influence P-glycoprotein expression in this model and at the levels studied.
Kellen
J A
JA
Sunnybrook Health Science Centre, University of Toronto, Ontario, Canada.
Georges
E
E
Ling
V
V
Dubsky
M
M
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000230:Adenocarcinoma / Q000473:pathology*; D000818:Animals; D000911:Antibodies, Monoclonal; D002455:Cell Division / Q000187:drug effects*; D004351:Drug Resistance; D008325:Mammary Neoplasms, Experimental / Q000473:pathology*; D008562:Membrane Glycoproteins / Q000032:analysis; D051381:Rats; D013629:Tamoxifen / Q000494:pharmacology; D017312:Toremifene / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000911:Antibodies, Monoclonal; D008562:Membrane Glycoproteins; D013629:Tamoxifen; D017312:Toremifene