Prospects for genetic diagnosis of inherited predisposition to cancer.
The best long-term prospects for the reduction in the number of deaths due to cancer lie with screening and prevention rather than with therapy of the advanced disease. Screening efficiency will be improved by the identification of individuals at inherited high risk of cancer. Understanding the mechanism of predisposition may provide the basis for rational attempts at prevention, as well as for new approaches to therapy.
Ponder
B A
BA
Department of Pathology, University of Cambridge, UK.
D002874:Chromosome Mapping; D004198:Disease Susceptibility; D005820:Genetic Testing; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000517:prevention & control; D009857:Oncogenes; D010375:Pedigree; D012307:Risk Factors