Expression of c-fos protein in the medulla oblongata of conscious rabbits in response to baroreceptor activation.
Neuronal expression of c-fos protein (Fos) in the medulla in response to baroreceptor activation was studied in conscious rabbits. Raising arterial pressure resulted in a marked increase, compared to control animals, in Fos immunoreactivity in the nucleus tractus solitarius, area postrema and ventrolateral medulla (VLM). Fos-immunoreactive neurons in the VLM extended from the level just rostral to the obex to 3 mm more caudal. Only a small proportion of these neurons showed tyrosine hydroxylase immunoreactivity. The results indicate that baroreceptor activation induces Fos expression in circumscribed medullary regions which have previously been shown to receive excitatory baroreceptor inputs.
Department of Physiology, University of Sydney, NSW, Australia.
Y W
YW
Li
R A
RA
Dampney
D000818:Animals; D007124:Immunoenzyme Techniques; D008526:Medulla Oblongata / Q000033:anatomy & histology / Q000166:cytology / Q000378:metabolism*; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology; D010656:Phenylephrine / Q000494:pharmacology; D011311:Pressoreceptors / Q000502:physiology*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis / Q000235:genetics*; D011817:Rabbits; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D016760:Proto-Oncogene Proteins c-fos; D010656:Phenylephrine; D014446:Tyrosine 3-Monooxygenase