Contraindications to vasoconstrictors in dentistry: Part III. Pharmacologic interactions.
This article discusses the relative contraindications to the use of vasoconstrictor in patients currently medicated with tricyclic antidepressants, monoamine oxidase inhibitors, phenothiazines and beta-blockers. It reviews drug interactions and emphasizes potential detrimental systemic effects that epinephrine contained in local anesthetics can have when administered concomitantly with these drugs. Finally, special considerations are expressed concerning patients who abuse illicit drugs such as cocaine.
Section of Oral Medicine, School of Dental Medicine, Université Laval, Ste.-Foy, Quebec, Canada.
J P
JP
Goulet
R
R
Pérusse
J Y
JY
Turcotte
D000208:Acute Disease; D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000494:pharmacology*; D000766:Anesthesia, Dental; D000772:Anesthesia, Local; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D003042:Cocaine / Q000009:adverse effects / Q000494:pharmacology*; D000075202:Contraindications; D003730:Dental Care for Persons with Disabilities; D004347:Drug Interactions; D004837:Epinephrine; D006329:Heart Conduction System / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D008996:Monoamine Oxidase Inhibitors / Q000009:adverse effects / Q000494:pharmacology*; D008771:Nordefrin; D009638:Norepinephrine; D010640:Phenothiazines; D019966:Substance-Related Disorders; D013610:Tachycardia / Q000139:chemically induced; D014662:Vasoconstrictor Agents
D000319:Adrenergic beta-Antagonists; D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D008996:Monoamine Oxidase Inhibitors; D010640:Phenothiazines; D014662:Vasoconstrictor Agents; D003042:Cocaine; D008771:Nordefrin; D009638:Norepinephrine; D004837:Epinephrine