Effects of senna and its active compounds rhein and rhein-anthrone on PAF formation by rat colon.
A single or a prolonged oral administration of senna (60 mg kg-1) to rats did not increase either colonic PAF (platelet activating factor) content or intraluminal release of acid phosphatase. A similar result was observed in the colonic tissue of rats perfused in-vitro with rhein (1-300 micrograms mL-1) or rhein-anthrone (1-300 micrograms mL-1). A single or prolonged administration of castor oil (2 mL) to rats increased both colonic PAF content and intraluminal release of acid phosphatase. Colonic tissue of rats perfused in-vitro with calcium ionophore A23187 (1 and 10 micrograms mL-1) formed large amounts of PAF and acid phosphatase. Since PAF can mediate intestinal damage and acid phosphatase is a marker of cellular injury, we conclude that senna and its derivatives, rhein and rhein-anthrone, are well tolerated in rats.
Department of Experimental Pharmacology, University of Naples, Italy.
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Mascolo
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Autore
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Izzo
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Biondi
F
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Capasso
D000818:Animals; D000873:Anthracenes / Q000494:pharmacology*; D000880:Anthraquinones / Q000494:pharmacology*; D000001:Calcimycin / Q000494:pharmacology; D003106:Colon / Q000378:metabolism*; D008297:Male; D010972:Platelet Activating Factor / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D012676:Senna Extract / Q000494:pharmacology*; D000095322:Anthrones
D000873:Anthracenes; D000880:Anthraquinones; D000001:Calcimycin; D010972:Platelet Activating Factor; D012676:Senna Extract; C055876:rhein-9-anthrone; D000095322:Anthrones; C020491:rhein