Effects of gadolinium on N-methyl-D-aspartate (NMDA)-induced centrogenic arrhythmias.
In urethane-anesthetized rats, the intracerebroventricular (i.c.v.) administration of N-methyl-D-aspartate (NMDA)-induced central arrhythmias. These cardiac rhythm disorders could be prevented by the i.c.v. microinjection of gadolinium, an inhibitor of exocytosis. These findings suggest that inhibition of central neurotransmitter exocytosis could protect against centrogenic arrhythmias.
Institute of Pharmacology and Toxicology, First Faculty of Medicine and Surgery, University of Naples, Italy.
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Berrino
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De Novellis
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Maione
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Cuparencu
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Rossi
D000758:Anesthesia; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D005089:Exocytosis / Q000187:drug effects; D005260:Female; D005682:Gadolinium / Q000008:administration & dosage / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D016202:N-Methylaspartate / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D018377:Neurotransmitter Agents / Q000037:antagonists & inhibitors; D051381:Rats; D017208:Rats, Wistar
D018377:Neurotransmitter Agents; D016202:N-Methylaspartate; D005682:Gadolinium