Immunocytochemical localization of insulin-like growth factor I in the hypothalamo-hypophyseal system of the adult rat.
Insulin-like growth factor I (IGF-I) is shown to be involved in the regulation of pituitary hormones. High IGF-I concentrations were detected in hypothalamus and pituitary during adulthood. This study was undertaken to analyze the cellular distribution of IGF-I in the hypothalamo-hypophyseal system of the adult rat using immunocytochemical procedures. IGF-I was found to be widely distributed throughout the hypothalamus; it was present in the magnocellular neurons of the supraoptic, paraventricular, and accessory nuclei. Moreover, nerve fibres and puncta containing immunoreactive IGF-I were localized in the median eminence and the posterior lobe of the pituitary. These results support possible IGF-I neuromodulatory or neurohormonal action in the hypothalamus on pituitary hormone regulation.
Servicio de Endocrinologia, Hospital Ramón y Cajal, Madrid, Spain.
F
F
Aguado
T
T
Fernández
R
R
Martínez-Murillo
J
J
Rodrigo
L
L
Cacicedo
F
F
Sánchez-Franco
D000818:Animals; D005455:Fluorescent Antibody Technique; D007030:Hypothalamo-Hypophyseal System / Q000276:immunology / Q000378:metabolism*; D007031:Hypothalamus / Q000276:immunology / Q000378:metabolism; D007150:Immunohistochemistry; D007334:Insulin-Like Growth Factor I / Q000276:immunology / Q000378:metabolism*; D008297:Male; D009474:Neurons / Q000378:metabolism; D010902:Pituitary Gland / Q000276:immunology / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013495:Supraoptic Nucleus / Q000276:immunology / Q000378:metabolism
D007334:Insulin-Like Growth Factor I