CD8 lymphocytosis and pseudotumoral splenomegaly in HIV infection.
Three patients infected with human immunodeficiency virus (HIV) presented with pseudotumoral splenomegaly, CD8 lymphocytosis (3.5-5.1 x 10(9)/l), and hypergammaglobulinaemia. Spleen and bone marrow showed diffuse CD8 lymphocyte and plasma-cell infiltration. Amplification of the T-cell-receptor gamma chain gene did not reveal any clonal T-cell population. Phenotypic analysis showed a predominance of CD8/CD57 suppressor T cells with expression of activation markers (DR and CD38). No cytotoxic T lymphocytes specific for HIV could be detected. The three patients shared the HLA haplotype A1, B8, DR3. The association with this haplotype suggests a genetically determined host immune response to HIV.
Department of Immunopathology and Haematology, Hôpital St Louis, Paris, France.
E
E
Oksenhendler
B
B
Autran
G
G
Gorochov
M F
MF
D'Agay
M
M
Seligmann
J P
JP
Clauvel
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000276:immunology; D000328:Adult; D016827:CD8 Antigens / Q000276:immunology / Q000302:isolation & purification*; D005260:Female; D006716:Homosexuality; D006801:Humans; D007111:Immunity, Cellular; D008218:Lymphocytosis / Q000150:complications* / Q000276:immunology; D008297:Male; D009894:Opportunistic Infections / Q000150:complications* / Q000276:immunology; D010641:Phenotype; D013163:Splenomegaly / Q000150:complications*
D016827:CD8 Antigens