Zinc and the regulation of vitamin B6 metabolism.
Pyridoxal kinase, a key enzyme in the formation of vitamin B6 coenzymes, requires a zinc-ATP complex as a substrate. Recent findings show that zinc-metallothionein facilitates the formation of the zinc-ATP complex. Thus, the concentration of zinc-metallothionein in tissues may serve in the regulation of vitamin B6 metabolism.
D000818:Animals; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D008668:Metallothionein / Q000502:physiology; D011731:Pyridoxal Kinase / Q000378:metabolism*; D011736:Pyridoxine / Q000378:metabolism*; D015032:Zinc / Q000494:pharmacology*
D008668:Metallothionein; D011731:Pyridoxal Kinase; D015032:Zinc; D011736:Pyridoxine