The genetics of multiple endocrine neoplasia (MEN).
Multiple Endocrine Neoplasia (MEN) refers to the family of diseases characterized by hyperplasia and/or tumoral proliferation in various organs derived from the neural crest. MEN are transmitted in an autosomal dominant fashion in affected pedigrees with a high degree of penetrance. MEN 1 and MEN 2A/B loci have recently been mapped, respectively, to chromosomes 11 and 10 by linkage analysis using polymorphic DNA markers. These discoveries will lead (1) to a rapid understanding of the physiopathological pathway determining such syndromes and (2) to major clinical impact through the genetic screening.
Laboratory of Genetics, Edouard Herriot Hospital, Lyon, France.
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Calender
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Schuffenecker
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Lenoir
D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10; D002880:Chromosomes, Human, Pair 11; D008040:Genetic Linkage; D005820:Genetic Testing; D006801:Humans; D009377:Multiple Endocrine Neoplasia / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length