Haptoglobin as a sensitive marker of hemolysis in HELLP-syndrome.
In a prospective study we measured laboratory variables of hemolysis in 25 patients with HELLP-syndrome. Reduced haptoglobin levels were observed in all 25 patients at diagnosis. Elevated bilirubin and plasma hemoglobin levels were observed in 5/25 patients while an abnormal peripheral blood smear was found in 11/25 patients. Our results suggest that haptoglobin is a sensitive parameter for early detection of moderate hemolysis in HELLP-syndrome and should be included in laboratory screening to aid diagnosis.
Department of Obstetrics and Gynecology, University of Göttingen, FRG.
G
G
Wilke
W
W
Rath
E
E
Schutz
V W
VW
Armstrong
W
W
Kuhn
D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D017359:HELLP Syndrome / Q000097:blood*; D006242:Haptoglobins / Q000378:metabolism*; D006461:Hemolysis; D006801:Humans; D011247:Pregnancy; D011446:Prospective Studies
D015415:Biomarkers; D006242:Haptoglobins