Lipid and lipoprotein (a) concentrations in renal transplant patients.
Lipid and lipoprotein concentrations, including lipoprotein (a), were measured in 67 clinically stable renal allograft recipients and compared with age- and sex-matched controls. Median lipoprotein (a) concentrations were significantly elevated in the transplant group (P = 0.048), with the distribution of apoprotein (a) isoforms being similar between the two groups. The transplant group also demonstrated significant elevations in cholesterol (P less than 0.0001), triglycerides (P = 0.0007) and low-density lipoprotein cholesterol (P less than 0.0001). There was no significant difference in high-density lipoprotein cholesterol concentrations between the groups although there was the expected tendency for higher values in females. Lipoprotein abnormalities are common following renal transplantation and these patients also demonstrate elevated lipoprotein (a) values. This unique lipoprotein is known to be atherogenic and may contribute to the development of vascular disease, which is a common mode of death in these patients.
Charing Cross and Westminster Medical School, Charing Cross Hospital, London, UK.
A T
AT
Webb
M
M
Plant
D A
DA
Reaveley
M
M
O'Donnell
V A
VA
Luck
B
B
O'Connor
M
M
Seed
E A
EA
Brown
D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000328:Adult; D003524:Cyclosporins / Q000494:pharmacology; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014184:Transplantation, Homologous
D000319:Adrenergic beta-Antagonists; D003524:Cyclosporins; D008055:Lipids; D008074:Lipoproteins