Light and electron microscopic immunocytochemical localization of glutamine synthetase in the superficial pineal gland of the rat.
Glutamine synthetase (L-glutamate:ammonia ligase; EC 6.3.1.2), an enzyme catalysing the ATP-dependent formation of glutamine from glutamate and ammonia, was detected immunocytochemically only in glial (interstitial) cells of the superficial pineal gland of the rat. The results show the important role of pineal glial cells in the metabolism of the presumptive neurotransmitters, glutamate and gamma-aminobutyric acid (GABA) as well as in detoxification of ammonia.
Institute of Histology and Embryology, Faculty of Medicine, University of Lausanne, Switzerland.
R
R
Krstić
D
D
Nicolas
D000818:Animals; D003593:Cytoplasm / Q000378:metabolism; D005260:Female; D005974:Glutamate-Ammonia Ligase / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009457:Neuroglia / Q000378:metabolism; D010870:Pineal Gland / Q000201:enzymology* / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D005680:gamma-Aminobutyric Acid; D005974:Glutamate-Ammonia Ligase