[Bladder neoplasm in a patient with panarteritis nodosa treated with cyclophosphamide].
Cyclophosphamide is used both in the treatment of malignant and non-malignant diseases. Urinary neoplasms secondary to its use have been described. We discuss the case of a patient with panarteritis nodosa treated with cyclophosphamide during 63 months, with a total dose of 210 grams, and that showed a bladder neoplasm 8 years after beginning of the treatment. In patients receiving a total dose of cyclophosphamide over 85 grams, a follow-up of ten years minimum should be performed aimed to the early detection of secondary neoplasms.
Servicio de Oncología Médica, Hospital General Valle de Hebrón, Barcelona.
J
J
Albanell
O S
OS
Gallego
J
J
Bellmunt
P
P
Vicente
S
S
Morales
L A
LA
Solé
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D001859:Bone Neoplasms / Q000556:secondary; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000139:chemically induced* / Q000601:surgery; D010212:Papilloma / Q000139:chemically induced* / Q000601:surgery; D010488:Polyarteritis Nodosa / Q000150:complications* / Q000188:drug therapy; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000601:surgery
D000305:Adrenal Cortex Hormones; D003520:Cyclophosphamide
Neoplasia de vejiga en un paciente afecto de panarteritis nodosa tratado con ciclofosfamida.