Involvement of D-amino acid oxidase in elimination of D-serine in mouse brain.
The physiological role of D-amino acid oxidase (EC 1. 4. 3. 3) in mouse brain is described. The presence of D-enantiomers of neutral common amino acids was surveyed in the brain. D-serine was shown to be present at high concentration only in regions where the enzyme activity was low. In normal mice whose D-amino acid oxidase activity was much higher in the cerebellum than in the cerebrum, free D-serine content was apparently lower in the cerebellum than in the cerebrum. In mice of a mutant strain lacking D-amino acid-oxidase activity, the free D-serine level was remarkably high both in the cerebrum and cerebellum. The results suggest that the enzyme is involved in the elimination of free D-serine in the cerebellum.
Department of Life Science, Himeji Institute of Technology, Japan.
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Nagata
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003605:D-Amino-Acid Oxidase / Q000378:metabolism*; D051379:Mice; D008817:Mice, Mutant Strains; D012694:Serine / Q000378:metabolism*; D013237:Stereoisomerism
D012694:Serine; D003605:D-Amino-Acid Oxidase