Poliovirus antigen chimeras.
Poliovirus, the aetiological agent of paralytic poliomyelitis, is arguably the best characterized of all animal viruses. Using recombinant-DNA technology, this information, together with the availability of infectious cDNA clones of the notably safe and efficacious live attenuated Sabin 1 vaccine strains of poliovirus, has enabled the creation of hybrid viruses (chimeras) possessing novel antigenicity. The potential applications of these 'epitope-presentation systems' include their use as immunogens, as antigens for serodiagnosis, and as vaccines.
Rose
C S
CS
Department of Microbiology, University of Reading, Whiteknights, UK.
Evans
D J
DJ
D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis; D000595:Amino Acid Sequence; D000956:Antigens, Viral / Q000235:genetics / Q000276:immunology*; D001483:Base Sequence; D004279:DNA, Viral; D015488:HIV Antigens / Q000235:genetics / Q000276:immunology; D008969:Molecular Sequence Data; D017955:Poliovirus / Q000235:genetics / Q000276:immunology*; D011994:Recombinant Proteins / Q000235:genetics / Q000276:immunology; D014765:Viral Vaccines
D000956:Antigens, Viral; D004279:DNA, Viral; D015488:HIV Antigens; D011994:Recombinant Proteins; D014765:Viral Vaccines