Familial occurrence of fixed drug eruptions.
Fixed drug eruptions following the use of pyrazolone derivatives occurred in 4 members of the same family: a 12-year-old girl, her grandmother, and two of her great aunts. Although the pathophysiologic events leading to this type of reaction are unknown, these cases of familial occurrence suggest that genetic predisposition might be an important causal factor.
Department of Dermatology, Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo (FG), Italy.
R
R
Pellicano
A
A
Silvestris
M
M
Iannantuono
G
G
Ciavarella
M
M
Lomuto
D002648:Child; D003875:Drug Eruptions / Q000235:genetics*; D005260:Female; D011298:Feprazone / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D010375:Pedigree
D011298:Feprazone