[Correlation of proliferation of pancreatic cancer cells with both saturation index and cell membrane insulin receptors].
Exogenous epidermal growth factor (or somatostatin) can stimulate (or inhibit) proliferation of pancreatic cancer cells, with a corresponding decrease (or increase) of the saturation index of the cell membrane and up-regulation (or down-regulation) of insulin receptor expression. By measuring the saturation index and insulin receptor numbers on the cell membrane it may be possible to evaluate the curative effects of treatment on pancreatic cancer at an early time.
PUMC Hospital, Beijing.
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Yao
D002455:Cell Division / Q000187:drug effects; D002462:Cell Membrane / Q000378:metabolism; D004815:Epidermal Growth Factor / Q000494:pharmacology; D006801:Humans; D009829:Oleic Acids / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology*; D011972:Receptor, Insulin / Q000378:metabolism*; D013004:Somatostatin / Q000494:pharmacology; D013229:Stearic Acids / Q000378:metabolism; D014407:Tumor Cells, Cultured
D009829:Oleic Acids; D013229:Stearic Acids; D013004:Somatostatin; D004815:Epidermal Growth Factor; D011972:Receptor, Insulin