[The acute toxicity of the microbial preparation bulmoscide].
The acute toxicity of a new Bulgarian microbial preparation bulmoscid on the basis of Bacillus thuringiensis H-14 in the conditions of oral, dermal, inhalation and intraperitoneal introduction in experimental animals is determined. The assessment of toxicity is made by using toxicometric, integral, hematologic, histologic and microbiologic methods in accordance with Bulgarian and international criteria and standards. It is established, that the preparation bulmoscid introduced orally in dose 5500 mg.kg-1 (6.6.10(10) cell kg-1), applied dermally in dose 6000 mg/kg-1 (7.2.10(10) cells kg-1) and in concentrations 18 mg.m-3 (2.2.10(8) cells m-3) for 14 day inhalation exposure, provokes no lethal exit and symptoms of intoxication and leads to no changes in the integral, hematologic and histologic investigations on experimental animals. The preparation belongs to the practically nontoxic substances. The studies of the acute toxicity show, that the microbial preparation bulmoscid offers no danger for appearing of oral, dermal and inhalation poisonings when observing the regulations for its production and use.
Khalkova
Zh
Zh
Zaĭkov
Kh
Kh
Khristeva
V
V
Dinoeva
S
S
Chipilska
L
L
D000208:Acute Disease; D000818:Animals; D001413:Bacillus thuringiensis; D004305:Dose-Response Relationship, Drug; D005260:Female; D007306:Insecticides / Q000008:administration & dosage / Q000506:poisoning / Q000633:toxicity*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009930:Organic Chemicals; D011041:Poisoning / Q000097:blood / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D007306:Insecticides; D009930:Organic Chemicals; C084026:bulmoscide
Izsledvane na ostrata toksichnost na mikrobniia preparat bulmostsid.