Localization of two new DNA markers on the linkage map of human chromosome 6q.
Recently, an autosomal homolog of the dystrophin gene (DMDL) was identified on chromosome 6q24. As part of our analysis of the DMDL locus, we endeavoured to isolate DNA markers to further define the genetic map of this region. We have isolated and characterized two new genetic markers in the region of the DMDL locus, the RFLP D6S129 and a (CA)n dinucleotide repeat polymorphism within the DMDL gene itself and have positioned them on the existing genetic map of chromosome 6q. These markers will be important in testing the hypothesis that the DMDL gene is the locus responsible for autosomal forms of neuromuscular disease.
Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.
B C
BC
Byth
D R
DR
Love
J C
JC
Murray
K E
KE
Davies
D001483:Base Sequence; D002896:Chromosomes, Human, Pair 6; D016189:Dystrophin / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D008126:Lod Score; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides / Q000235:genetics; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length
D016189:Dystrophin; D005819:Genetic Markers; D009838:Oligodeoxyribonucleotides