Seroepidemiology of schistosomiasis mansoni.
In population surveys in which the Schistosoma mansoni intensity of infection is low, or in localities where the schistosomiasis control program had success, the parasitologic methods lack in sensitivity. Despite of some limitations, the immunological methods are useful to provide valuable information in such field conditions. Thus, the prevalence of schistosomiasis in untreated population can be determined by the detection of IgG or IgM antibodies, as well as the incidence by the IgA antibodies, employing mainly immunofluorescence (IF) and immunoenzymatic (ELISA), and in some extent hemagglutination (HA) or even skin test. The true prevalence and incidence of schistosomiasis can be estimated using a probabilistic model equation, since knowing before-hand the sensitivity and specificity of employed test. The sensitivity and the specificity of serologic test become higher in low aged group, under 14. The geometric mean IF titers also gives a positive correlation with the intensity of infection. Presently, there are need of serologic tests which are economic and practical in seroepidemiologic inquiries, requiring no specialized personnel to collect population blood or serum samples, and also easily interpret the test results. The reagents for such tests are desired to be stable and reproducible. Moreover, it is expected that the tests can distinguish an active infection.
Fac. Ciências Farmacêuticas, USP, São Paulo, Brasil.
S
S
Hoshino-Shimizu
L C
LC
Dias
H Y
HY
Kanamura
L C
LC
Silva
C M
CM
Glasser
R M
RM
Patucci
D000293:Adolescent; D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood*; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005455:Fluorescent Antibody Technique; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000097:blood; D015994:Incidence; D007223:Infant; D011237:Predictive Value of Tests; D015995:Prevalence; D012550:Schistosoma mansoni / Q000276:immunology*; D012555:Schistosomiasis mansoni / Q000453:epidemiology* / Q000276:immunology; D012680:Sensitivity and Specificity; D016036:Seroepidemiologic Studies
D000909:Antibodies, Helminth; D007132:Immunoglobulin Isotypes