Could CAPD modulate the hemodynamic changes induced by rHuEPO treatment?
Hemodynamic response to treatment with erythropoietin has been analyzed on two different groups of patients. The first group of 25 patients was treated with hemodialysis. The second group of 27 was treated with peritoneal dialysis. Both groups were studied before starting the treatment with erythropoietin, after reaching the hemoglobin target point, and after one year of treatment. The following parameters were recorded: basal and hemoglobin target point, time and dosage of response, incidence of arterial hypertension, diastolic and systolic left ventricular diameters, interventricular septum and posterior wall thickness, ejection fraction, fractional fiber shortening, left ventricular mass index, cardiac output index and peripheral resistance index. The incidence of hypertension was 28.8% and, in both techniques, stabilization of left ventricular mass index occurred a year later. When the hemoglobin target point was reached, a decrease in cardiac output and an increase in peripheral resistance was found. These changes were more evident in the group of patients treated with HD. After a year of treatment, both peripheral resistance and cardiac output were similar to basal values in both groups of patients.
Fernández
A
A
Nephrology Service, Hospital Nuestra Señora del Pino, Las Palmas de Gran Canaria, Canary Islands, Spain.
Vega
N
N
Hortal
L
L
Jimenez
F
F
Laraudogoitía
E
E
Macía
M
M
Plaza
C
C
Perdomo
M
M
Palop
L
L
D000328:Adult; D000740:Anemia / Q000209:etiology / Q000628:therapy; D001794:Blood Pressure; D002302:Cardiac Output; D004452:Echocardiography; D004921:Erythropoietin / Q000627:therapeutic use*; D006439:Hemodynamics; D006801:Humans; D008875:Middle Aged; D009200:Myocardial Contraction; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects; D011446:Prospective Studies; D011994:Recombinant Proteins / Q000627:therapeutic use; D006435:Renal Dialysis / Q000009:adverse effects; D014655:Vascular Resistance; D016277:Ventricular Function, Left
D011994:Recombinant Proteins; D004921:Erythropoietin