Blood flow hydrodynamic resistance in patients with ischaemic stroke or vascular encephalopathy and possibilities of its correction in vitro.
In order to determine the patient blood flow hydrodynamic properties in terms of the Toms-effect, the time blood flow was measured in special apparatus twice: (1) before and (2) after addition of poly(ethylene oxide) WSR-301 (Union Carbide, USA) in concentration of 2 x 10(6) g/ml of blood sample (50 ml with 500 units of heparin) taken from 26 patients with acute ischaemic stroke, 8 patients with vascular encephalopathy after stroke, 5 patients with vascular encephalopathy following atherosclerosis with or without arterial hypertension. The blood samples taken from 8 healthy persons formed the control group. Haematocrit (HCT) and asymptotic blood viscosity were studied also. It was established that hydrodynamic blood flow resistance (HBFR) did not depend on HCT and viscosity, but was significantly higher in all patient groups than in normal persons (p less than 0.05). Addition of polymer solution decreased HBFR of patient blood more intensively that in the control group. We believe that it indicates an insufficiency of an unidentified factor in native human blood.
Institute of Neurology, Academy of Medical Sciences, Moscow, Russia.
I V
IV
Gannushkina
A L
AL
Antelava
I L
IL
Konorova
Z A
ZA
Suslina
N V
NV
Lebedeva
D000328:Adult; D001161:Arteriosclerosis / Q000150:complications; D001809:Blood Viscosity; D002545:Brain Ischemia / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006400:Hematocrit; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D014655:Vascular Resistance