[Twenty-eight-day repeated dose toxicity test of pentaerythritol in F344 rats].
A twenty-eight-day repeated dose toxicity test of pentaerythritol at dose levels of 1000 or 0 mg/kg/day was carried out in male and female F344 rats. Thirteen animals of each sex were divided into 2 groups with 7 rats receiving pentaerythritol treatment and 6 rats served saline as control. All groups received an i.g. administration daily for 28 days. As to serum biochemical and hematological examinations, there were no serious differences between the pentaerythritol-treated rats and the control rats. On histopathological examination, no specific changes were observed in the pentaerythritol-treated rats. Based on these results, the no-observed-effect level of pentaerythritol can be concluded to be more than 1000 mg/kg/day.
S
S
Hayashi
K
K
Toyoda
K
K
Furuta
C
C
Uneyama
T
T
Kawanishi
K
K
Imaida
M
M
Takahashi
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005260:Female; D006321:Heart / Q000187:drug effects; D006403:Hematologic Tests; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011409:Propylene Glycols / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors
D011409:Propylene Glycols; C008783:pentaerythritol