Insulin gene region-encoded susceptibility to type 1 diabetes is not restricted to HLA-DR4-positive individuals.
Type 1 or insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease of the insulin-producing pancreatic beta-cells which is determined by both genetic and environmental factors. The major histocompatibility complex and the insulin gene region (INS) on human chromosomes 6p and 11p, respectively, contain susceptibility genes. Using a mostly French data set, evidence for linkage of INS to IDDM was recently obtained but only in male meioses (suggesting involvement of maternal imprinting) and only in HLA-DR4-positive diabetics. In contrast, we find evidence for linkage in both male and female meioses and that the effect of the susceptibility gene(s) in the INS region is not dependent on the presence of HLA-DR4.
Bain
S C
SC
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, UK.
Prins
J B
JB
Hearne
C M
CM
Rodrigues
N R
NR
Rowe
B R
BR
Pritchard
L E
LE
Ritchie
R J
RJ
Hall
J R
JR
Undlien
D E
DE
Ronningen
K S
KS
D001483:Base Sequence; D002460:Cell Line; D003922:Diabetes Mellitus, Type 1 / Q000208:ethnology / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D015804:HLA-DR4 Antigen / Q000032:analysis / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007328:Insulin / Q000235:genetics*; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008540:Meiosis / Q000235:genetics; D008969:Molecular Sequence Data; D009664:Norway; D010290:Parents; D012307:Risk Factors; D006113:United Kingdom
D015804:HLA-DR4 Antigen; D007328:Insulin