Molecular genetics of sex determination in C. elegans.
Sexual fate in the nematode Caenorhabditis elegans is controlled by a group of genetically well-characterized genes. Several of these sex-determining genes have now been analysed at the molecular level. Transcriptional regulation is likely to control both commitment to a single sexual fate and maintenance of that decision; in addition, intercellular signalling appears to coordinate the sexual fates of cells throughout the animal to adopt a single sexual fate.
Department of Biochemistry, College of Agriculture and Life Sciences, University of Wisconsin-Madison 53706, USA.
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PE
Kuwabara
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Kimble
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D002450:Cell Communication; D012734:Disorders of Sex Development / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D017238:Genes, Helminth; D015801:Helminth Proteins / Q000502:physiology; D008957:Models, Genetic; D012730:Sex Chromosomes; D012732:Sex Determination Analysis; D015398:Signal Transduction; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic; D016335:Zinc Fingers
D015801:Helminth Proteins; D014157:Transcription Factors