[Pharmacologic defense of the brain in radiation injury: some arguments].
Based on an analysis of the latest data on the problem of pharmacologic defense, the pro and contra scientific arguments of using pharmacochemical countermeasures to radiation damages of the brain are discussed in succession. A comparative characteristic of positive and negative effects of countermeasures possessing various neurotropic properties is presented. A general scheme of searching for the means of pharmacologic correction of radiocerebral syndrome involving the following stages: pathophysiologic analysis of cerebral disorders; selection of behaviorally significant (psychophysiologic) criteria; search for pharmacochemical correction means; experimental animals studies with extrapolating their results to a man; radiocerebral syndrome simulation (pharmacologic, physical and chemical); field tests; decision-making (medico-biological and formalized approaches) is presented. "Pyramid of complexity" of radiocerebral effects extrapolation from the animals to a man to suit an hierarchy of the biological structures is presented. The effectiveness of conditionally-quantitative relationships of the drugs of prolonged and short-term effect as applied to various radiation syndromes (erythropoietic, gastrointestinal and cerebral) is discussed.
Davydov
B I
BI
Ushakov
I B
IB
D000337:Aerospace Medicine; D000465:Algorithms; D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects* / Q000528:radiation effects; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008889:Military Personnel; D008954:Models, Biological; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000188:drug therapy* / Q000209:etiology; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000209:etiology; D013997:Time Factors; D014149:Tranquilizing Agents / Q000627:therapeutic use*; D014586:USSR
D000928:Antidepressive Agents; D000697:Central Nervous System Stimulants; D014149:Tranquilizing Agents
Farmakologicheskaia zashchita mozga pri radiatsionnom porazhenii: nekotorye argumenty.