NO., CO and .OH. Endogenous soluble guanylyl cyclase-activating factors.
Several low molecular weight compounds are capable of activating soluble guanylyl cyclase. Recent evidence suggests that some of these are formed under physiological conditions: the nitric oxide radical, carbon monoxide and the hydroxyl radical. Thus, multiple signal transduction pathways appear to exist that form a family of guanylyl cyclase activating factors and thereby regulate the intracellular cyclic guanosine 3',5'-monophosphate level.
Northwestern University Medical School, Department of Pharmacology, Chicago, IL 60611.
H H
HH
Schmidt
D000818:Animals; D002248:Carbon Monoxide / Q000378:metabolism; D004789:Enzyme Activation; D005609:Free Radicals / Q000378:metabolism; D006162:Guanylate Cyclase / Q000378:metabolism*; D006801:Humans; D006878:Hydroxides / Q000378:metabolism; D017665:Hydroxyl Radical; D009569:Nitric Oxide / Q000378:metabolism; D012995:Solubility
D005609:Free Radicals; D006878:Hydroxides; D009569:Nitric Oxide; D017665:Hydroxyl Radical; D002248:Carbon Monoxide; D006162:Guanylate Cyclase