Antibody production in packed bed reactors using serum-free and protein-free medium.
The present work demonstrates the utility of packed bed reactors for the production of monoclonal antibody. We present data from a continuous process run for the production of over 100 grams of antibody, using serum-free medium. An additional pilot run also demonstrates the potential for continued antibody production under protein-free conditions, using a standard basal medium.
Bliem
R
R
Baxter Hyland Division, Hayward, CA 94545.
Oakley
R
R
Matsuoka
K
K
Varecka
R
R
Taiariol
V
V
D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis*; D001709:Biotechnology; D002455:Cell Division; D003470:Culture Media; D006825:Hybridomas / Q000166:cytology / Q000276:immunology; D007158:Immunologic Techniques
D000911:Antibodies, Monoclonal; D003470:Culture Media