HLA genotyping of colorectal carcinoma in the Chinese population.
The HLA-DR genotypes of 61 primary colorectal carcinomas obtained from patients of Chinese origin were determined by using DNA-RFLP. No increase or decrease of a particular HLA genotype could be ascertained with the disease, although we detected an antigen frequency of 29.5% for the serologically ill-defined DR"X3" specificity. We identified and sequenced HLA-DRB1 and DRB3 genes from the DR"X3" haplotype. The DR"X3" DRB1 gene was found to be identical to DRB1*1201 (DR5[w12]). A unique observation is its unusual linkage with DRB3*0101 (DRw52a) or DRB3*0301 (DRw52c) instead of the usual linkage with DRB3*0201/2 (DRw52b). These associations are rare in whites and blacks.
UK Transplant Support Service Authority, Bristol, London, England.
J L
JL
Bidwell
T W
TW
Soong
P A
PA
Raymond
D G
DG
Doherty
K M
KM
Hui
D000483:Alleles; D000951:Antigens, Neoplasm / Q000235:genetics*; D002681:China; D015179:Colorectal Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D005787:Gene Frequency; D005802:Genes, MHC Class II; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006684:HLA-DR Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length
D000951:Antigens, Neoplasm; D006684:HLA-DR Antigens