An in vitro gas equilibration method for determination of chemical partition coefficients in fish.
1. A gas equilibration method for the determination of in vitro chemical partition coefficients in mammals was adapted for use with fish. 2. In vitro blood: water and tissue: blood partition coefficients were determined for three chlorinated ethanes in rainbow trout (Oncorhynchus mykiss). 3. In vitro partition coefficients accurately predicted chemical concentrations in tissues of exposed trout.
United States Environmental Protection Agency, Environmental Research Laboratory--Duluth, MN.
A D
AD
Hoffman
S L
SL
Bertelsen
M L
ML
Gargas
D000273:Adipose Tissue / Q000737:chemistry; D000818:Animals; D001784:Blood Gas Analysis; D004980:Ethane / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood; D006843:Hydrocarbons, Chlorinated / Q000032:analysis* / Q000097:blood; D066298:In Vitro Techniques; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D009132:Muscles / Q000737:chemistry; D009997:Osmotic Pressure; D014337:Trout
D006843:Hydrocarbons, Chlorinated; C016134:tetrachloroethane; C010182:hexachloroethane; D004980:Ethane; C016036:pentachloroethane