Memory in helper T cells of minor histocompatibility antigens, revealed in vivo by alloimmunizations in combination with Thy-1 antigen.
A cooperative antibody response in which T helper (Th) cells recognize minor histocompatibility antigens (mha) and B cells recognize Thy-1 antigen, is used to explore memory in the T cell compartment. In contrast to B cell memory, Th memory reaches a plateau rapidly, although Th memory of Thy-1 itself (or an associated antigen) behaves exceptionally in this respect. The plateau then extends over several weeks at least. Single mha, among them H-Y, generate detectable memory. Incompatible H-2 antigens, including class I antigens on their own, inhibit this response through what appears to be a mechanism of intracellular antigenic competition. Antigen presentation in this system is by host cells, as judged by lack of donor-specific restriction. Memory resides in both the CD45RA+ and CD45RA- compartments, although the majority of memory Th cells have the latter phenotype.
Imperial Cancer Research Fund Tumour Immunology Unit, University College London.
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E
Lightstone
J
J
Marvel
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A
Mitchison
D000818:Animals; D015703:Antigens, CD / Q000032:analysis; D000954:Antigens, Surface / Q000276:immunology*; D006649:Histocompatibility Antigens / Q000032:analysis; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D007114:Immunization; D007156:Immunologic Memory; D017493:Leukocyte Common Antigens; D051379:Mice; D008815:Mice, Inbred Strains; D015778:Minor Histocompatibility Antigens / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D018800:Thy-1 Antigens
D015703:Antigens, CD; D000954:Antigens, Surface; D006649:Histocompatibility Antigens; D015395:Histocompatibility Antigens Class I; D015778:Minor Histocompatibility Antigens; D018800:Thy-1 Antigens; D017493:Leukocyte Common Antigens