T1801 A, B, C, and D, new quinone and hydroquinone antibiotics produced by a strain of Pseudomonas.
New antibiotics, T1801 A, B, C, and D, were isolated from the culture broth of Pseudomonas sp. SC-1801. Their structures were found by spectroscopic analyses to be tri- and tetra(methylthio) derivatives of hydroquinone (T1801 A and C) or p-benzoquinone (T1801 B and D). They are new quinone and hydroquinone antibiotics and are active against Gram-positive bacteria, some fungi, and yeasts.
Biotechnology Laboratory, Takarazuka Research Center, Sumitomo Chemical Co., Ltd., Hyogo, Japan.
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Kumagai
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Kato
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Nabeshima
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Tsuyumu
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D016227:Benzoquinones / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006873:Hydroquinones / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011549:Pseudomonas / Q000145:classification / Q000378:metabolism*; D011809:Quinones / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D015003:Yeasts / Q000187:drug effects
D000900:Anti-Bacterial Agents; D016227:Benzoquinones; D006873:Hydroquinones; D011809:Quinones; C078119:T1801 A; C078120:T1801 D; C078121:T1801 B; C078118:T1801 C