Clonal deletion of V beta 17 T cells in mice from natural populations.
In a panel of wild mice trapped in different geographical regions, the concomitant expression of V beta 17 T cell receptors and I-E histocompatibility molecules is frequent. By Southern blot analysis, eight forms of V beta 17 genes have been distinguished that encode five kinds of V beta 17 domains. Populations of Asia display the highest level of polymorphism and include all the V beta 17 forms and domains. The V beta 17 T cells of wild origin are deleted in mice expressing Mls-3 and related superantigens. Wild mice use V beta 17 domains different than the one of laboratory strains. Together with endogenous superantigens polymorphism, this accounts for the observed low frequency of clonal deletion cases in natural populations.
Département d'Immunologie, Institut Pasteur (UA CNRS 359), Paris, France.
E
E
Jouvin-Marche
P N
PN
Marche
P A
PA
Cazenave
D000595:Amino Acid Sequence; D000818:Animals; D001208:Asia; D015139:Blotting, Southern; D005060:Europe; D015870:Gene Expression; D005828:Genetics, Population; D000949:Histocompatibility Antigens Class II / Q000096:biosynthesis; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics; D051379:Mice / Q000235:genetics* / Q000276:immunology; D008969:Molecular Sequence Data; D016366:Open Reading Frames / Q000235:genetics; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000096:biosynthesis / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D013601:T-Lymphocytes / Q000276:immunology*
D000949:Histocompatibility Antigens Class II; D016693:Receptors, Antigen, T-Cell, alpha-beta