The chiral chromatographic separation of beta-adrenoceptor blocking drugs.
Over 100 chromatographic procedures for the separation of beta-blocker enantiomers are reviewed including a large number for the analysis of biological samples. All the principal chiral chromatographic procedures have found use, namely Chiral Mobile Phase Additives (CMPA), Chiral Derivatization Agents (CDA) and Chiral Stationary Phases (CSP). Chiral Mobile Phase Additives are less frequently employed than the other two procedures and many of the earlier methods were based on the use of CDAs. However, the recent development of sophisticated custom-made CSPs has allowed the separation of native (underivatized) analytes and this approach appears to be gaining in popularity. The beta-blockers are an extensive group of drugs and stereoselective separations have been reported for 40 different structures.
International Development Laboratories, Bristol-Myers Squibb Pharmaceutical Research Institute, Moreton, Merseyside, UK.
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D000319:Adrenergic beta-Antagonists / Q000032:analysis*; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D013237:Stereoisomerism
D000319:Adrenergic beta-Antagonists