The suppression of olfactory bulbectomy-induced muricide by antidepressants and antihistamines via histamine H1 receptor blocking.
The effects of antidepressants [(+)-oxaprotiline, (-)-oxaprotiline, imipramine, maprotiline, and trazodone] and antihistamines (mepyramine, dimethindene, ketotifen, methapyrilene, and antazoline) on muricidal behaviour in olfactory bulbectomized rats were investigated. All drugs except for dimethindene, which only minimally passes across the blood-brain barrier, suppressed muricide. The drugs which have high affinity for histamine H1 receptor showed potent suppressive effect on muricide. It is suggested that the central histaminergic system is involved via H1 receptors in the expression of muricide in olfactory bulbectomized rats.
Biological Research Laboratories, Pharmaceutical Division, Ciba-Geigy (Japan) Limited, Takarazuka.
S
S
Noguchi
T
T
Inukai
T
T
Kuno
C
C
Tanaka
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001667:Binding, Competitive / Q000187:drug effects; D002417:Cattle; D004305:Dose-Response Relationship, Drug; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D066298:In Vitro Techniques; D008376:Maprotiline / Q000031:analogs & derivatives / Q000494:pharmacology; D009830:Olfactory Bulb / Q000502:physiology*; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains; D011969:Receptors, Histamine H1 / Q000187:drug effects / Q000378:metabolism
D000928:Antidepressive Agents; D006634:Histamine H1 Antagonists; D011969:Receptors, Histamine H1; D008376:Maprotiline; C027299:hydroxymaprotilin