An overdose of ecstasy. A role for dantrolene.
An overdose of the semisynthetic, hallucinogenic amphetamine 3,4-methylenedioxymethamphetamine resulted in convulsions, hyperthermia, hyperkalaemia and rhabdomyolysis. The patient's management, which included the use of dantrolene, is discussed.
Department of Anaesthesia, Southlands Hospital, Shoreham by Sea, West Sussex.
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Singarajah
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Lavies
D015104:3,4-Methylenedioxyamphetamine / Q000031:analogs & derivatives*; D000328:Adult; D003620:Dantrolene / Q000627:therapeutic use*; D006801:Humans; D007362:Intensive Care Units; D007385:Intermittent Positive-Pressure Ventilation; D008297:Male; D018817:N-Methyl-3,4-methylenedioxyamphetamine; D019966:Substance-Related Disorders / Q000188:drug therapy* / Q000503:physiopathology
D015104:3,4-Methylenedioxyamphetamine; D003620:Dantrolene; D018817:N-Methyl-3,4-methylenedioxyamphetamine