[Interactions between GABAergic and cholinergic mechanisms involved in monocular optokinetic nystagmus in frogs].
The systemic administration of atropine, a muscarinic cholinergic antagonist, was found to suppress the Nasal-Temporal (N-T) component of the frog monocular optokinetic nystagmus (OKN), which had appeared following a prior injection of bicuculline and which does not exist in the normal animal. On the contrary, the administration of a nicotinic cholinergic antagonist (D-TC, alpha-BGT, Hexamethonium) following that of bicuculline has prolonged the duration of the induced N-T component. Thus, ACh was shown to attenuate or to reinforce the GABAergic inhibition of the N-T component through muscarinic receptors or nicotinic receptors respectively. These data point to the existence of strong interactions between these two neurotransmission systems involved in frog monocular OKN.
Bonaventure
N
N
Laboratoire de Neurophysiologie et Biologie des Comportements, U.P.R. n. 419 du C.N.R.S., Strasbourg.
Jardon
B
B
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002794:Choline / Q000502:physiology*; D005730:Ganglionic Blockers / Q000494:pharmacology; D017120:Nystagmus, Optokinetic / Q000187:drug effects / Q000502:physiology*; D011893:Rana esculenta; D015349:Vision, Monocular / Q000187:drug effects / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D005730:Ganglionic Blockers; D005680:gamma-Aminobutyric Acid; D001285:Atropine; D002794:Choline
Interactions de mécanismes GABAergiques et cholinergiques impliqués dans le nystagmus optocinétique monoculaire de la grenouille.