Pulmonary involvement in nephropathia epidemica as demonstrated by computed tomography.
In a prospective study 19 adult patients with nephropathia epidemica were examined in the acute phase of disease with computed tomography (CT) of the lungs and conventional chest radiography. Infiltrates and/or pleural effusions were seen in ten of 19 patients. In two of the patients, abnormalities were disclosed only by CT. Patients with pathologic radiography findings had a more pronounced inflammatory response, as measured by C-reactive protein and leukocyte count, than did those with normal radiography findings. It is concluded that radiological evidence of pulmonary involvement is a common finding early in the course of nephropathia epidemica. The possibility that the lung may be a site of viral replication merits further investigation.
Dept. of Infectious Diseases, University of Umeå, Sweden.
M
M
Linderholm
A
A
Billström
B
B
Settergren
A
A
Tärnvik
D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D005455:Fluorescent Antibody Technique; D006476:Orthohantavirus / Q000145:classification*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000150:complications* / Q000175:diagnosis / Q000382:microbiology; D006785:Hospitals, University; D006801:Humans; D007958:Leukocyte Count; D008171:Lung Diseases / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013548:Sweden / Q000453:epidemiology; D014057:Tomography, X-Ray Computed
D002097:C-Reactive Protein