[Menadione induction of Ca2+ efflux from the mitochondria and of mediator secretion from the nerve endings].
It is shown that menadion increases the rate of Ca2+ efflux from mitochondria which decreases in the presence of ditiotreitol. Menadion at concentration of 50 microM induces Ca2+ efflux from mitochondria and its effect on synaptic transmission is discussed.
Kalikulov
D
D
Asrarov
M I
MI
Usmanov
P B
PB
Gagel'gans
A I
AI
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002463:Cell Membrane Permeability / Q000187:drug effects; D004229:Dithiothreitol / Q000494:pharmacology; D066298:In Vitro Techniques; D007425:Intracellular Membranes / Q000187:drug effects; D008564:Membrane Potentials / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D009411:Nerve Endings / Q000187:drug effects* / Q000378:metabolism; D009469:Neuromuscular Junction / Q000187:drug effects / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011896:Rana temporaria; D051381:Rats; D014812:Vitamin K / Q000494:pharmacology*
D018377:Neurotransmitter Agents; D014812:Vitamin K; D002118:Calcium; D004229:Dithiothreitol
Induktsiia menadionom vykhoda Ca2+ iz mitokhondriĭ i sekretsii mediatora iz nervnykh okonchaniĭ.