Designing peptide and protein ligands for biological receptors.
A clearer understanding of structure-function relationships of protein hormone-receptor systems is emerging from the increased use of molecular biology approaches. On the other hand, the introduction of rationally designed conformation constraints into peptide hormones and neurotransmitters is leading to the development of highly receptor-selective ligands that allow further investigations into the topographic modulation of their bioactivities and rational design principles for peptide antagonists.
Hruby
V J
VJ
Department of Chemistry, University of Arizona, Tucson 85721.
Sharma
S D
SD
D000595:Amino Acid Sequence; D006727:Hormone Antagonists / Q000737:chemistry; D006728:Hormones / Q000737:chemistry*; D008024:Ligands; D008969:Molecular Sequence Data; D011487:Protein Conformation; D015202:Protein Engineering; D011956:Receptors, Cell Surface / Q000737:chemistry*; D013329:Structure-Activity Relationship
D006727:Hormone Antagonists; D006728:Hormones; D008024:Ligands; D011956:Receptors, Cell Surface