The use of albumin microspheres in the treatment of carrageenan-induced inflammation in the rat.
Free hydrocortisone, hydrocortisone incorporated into microspheres and empty microspheres have been administered orally to rats with carrageenan-induced hindpaw inflammation. Hydrocortisone administered in particles was effective at a lower dose than free steroid in reducing inflammation. Inflammatory exudates were able to release steroid from the microspheres by proteolytic degradation.
Lewis
D A
DA
Pharmaceutical Sciences Institute, Aston University, Birmingham, UK.
Field
W N
WN
Hayes
K
K
Alpar
H O
HO
D000818:Animals; D002351:Carrageenan; D004337:Drug Carriers; D016650:Fluorescein-5-isothiocyanate; D005452:Fluoresceins; D006854:Hydrocortisone / Q000008:administration & dosage / Q000627:therapeutic use*; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008854:Microscopy, Electron; D008863:Microspheres; D010316:Particle Size; D051381:Rats; D012710:Serum Albumin, Bovine
D004337:Drug Carriers; D005452:Fluoresceins; D012710:Serum Albumin, Bovine; D002351:Carrageenan; D016650:Fluorescein-5-isothiocyanate; D006854:Hydrocortisone