[Antithrombin III in chronic renal insufficiency].
In a group of fourty eight patients with chronic renal failure and a group of twenty patients on chronic hemodialysis, we studied the biologic activity of Antithrombin III by using immunoelectrophoresis and coagulation methods. We found that increased values of biologic activity of Antithrombin III, were significant. This can be an additional factor in explaining the origin of bleeding in patients with chronic renal failure and uremia without nephrotic syndrome. The index of biologic activity of Antithrombin III was significantly decreased after giving heparin to the patients with chronic renal failure on hemodialysis. The obtained values were low and within the ranges found in patients suffering from thrombosis. This decrease in biologic activity of Antithrombin III, together with the well known increase in factors of hemostasis during hemodialysis, is an important cause of frequent thrombosis, which can be fatal for patients. In the same group, antigenic values of Antithrombin III measured before and after giving heparin, were not changed. These facts show the necessity of measuring the biologic activity of Antithrombin III because the quantity of Antithrombin III is not a reliable indicator of its functional validity.
Bekić-Kaluza
S
S
Macanović
M
M
D000990:Antithrombin III / Q000032:analysis*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D006435:Renal Dialysis
D000990:Antithrombin III
Antitrombin III u hronicnoj bubreznoj insuficijenciji.