Recurrent juvenile dermatomyositis and cutaneous necrotizing arteritis with molecular mimicry between streptococcal type 5 M protein and human skeletal myosin.
An adult patient had a syndrome associating the features of juvenile dermatomyositis and cutaneous polyarteritis nodosa that followed a cyclic course from childhood; recurrences were always associated with a rise of serum antistreptococcal antibodies. Regions of homology between streptococcal type 5 M protein and skeletal myosin were found. These findings suggest that streptococcal infection, possibly through a molecular mimicry mechanism, played a role in the pathogenesis of the disease in our patient.
Clinica Pediatrica Università di Pavia, Italy.
A
A
Martini
A
A
Ravelli
S
S
Albani
S
S
Viola
M S
MS
Scotta
U
U
Magrini
G R
GR
Burgio
D000208:Acute Disease; D000328:Adult; D000942:Antigens, Bacterial; D000989:Antistreptolysin / Q000032:analysis; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins / Q000737:chemistry*; D002352:Carrier Proteins; D003882:Dermatomyositis / Q000150:complications* / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D008297:Male; D009218:Myosins / Q000737:chemistry*; D009336:Necrosis; D010488:Polyarteritis Nodosa / Q000150:complications* / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D012008:Recurrence; D017386:Sequence Homology, Amino Acid; D017445:Skin Diseases, Vascular / Q000150:complications* / Q000276:immunology / Q000378:metabolism / Q000382:microbiology
D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; C014689:streptococcal M protein; D000989:Antistreptolysin; D009218:Myosins