Synteny mapping of the bovine IGHG2, CRC and IGF1 genes.
A panel of bovine-murine hybrid cell lines was analysed for 10 loci, including three (IGF1, IGHG2 and the calcium release channel gene [CRC]) that have previously been mapped in man, but not in cattle. The IGF and CRC genes were indirectly mapped to chromosomes 5 and 18 respectively and the syntenies of the HOX2 and GH genes and of the NP and FOS genes were confirmed. The results also show that the IGHG2 locus, which is linked to NP and FOS on human chromosome 14, is separated from these genes in cattle. By showing synteny of the IGHG2 and MPI loci, the IGHG2 locus has been indirectly mapped to chromosome 21.
Department of Molecular Physiology, Cambridge Research Station, Babraham, UK.
J R
JR
Miller
P D
PD
Thomsen
S C
SC
Dixon
E M
EM
Tucker
B A
BA
Konfortov
I
I
Harbitz
D000818:Animals; D015220:Calcium Channels / Q000737:chemistry*; D002417:Cattle / Q000235:genetics*; D002874:Chromosome Mapping; D002877:Chromosomes, Human; D005796:Genes; D005801:Genes, Homeobox; D013006:Growth Hormone / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells; D007142:Immunoglobulin gamma-Chains / Q000235:genetics*; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D051379:Mice; D005810:Multigene Family; D012756:Sheep; D013552:Swine
D015220:Calcium Channels; D007142:Immunoglobulin gamma-Chains; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone