[State of the pancreatic insular apparatus in experimental diabetes mellitus with varying degrees of severity in the rat].
The interrelationship between endocrine cells of the Langerhans islands in experimental diabetes provoked in female Wistar rats are studied. The content of the insulin in B-cells, glucagon in A-cells and somatostatin in D-cells was determined by method of indirect immunofluorescence with the use of monoclonal antibodies and antiserum. It is established that an decrease of the insulin content in B-cells is followed by an increase of glucagon in A-cells and that of somatostatin in D-cells. The increase of the glucagon content is proportional to glycemia level and to the decrease of the insulin in B-cells.
Kolesnik
Iu M
IuM
Vasilenko
G V
GV
Abramov
A V
AV
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D005260:Female; D005934:Glucagon / Q000032:analysis; D007328:Insulin / Q000032:analysis; D007515:Islets of Langerhans / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000032:analysis
D007328:Insulin; D013004:Somatostatin; D005934:Glucagon
Sostoianie ostrovkovogo apparata podzheludochnoĭ zhelezy pri éksperimental'nom sakharnom diabete razlichnoĭ stepeni tiazhesti u krys.