[Effect of 8-hydroxycarteolol in normal human eyes].
The authors studied the ocular hypotensive effect of 8-hydroxycarteolol, a main metabolite of carteolol in normal human eyes, after topical administration in a double masked randomized study. After instillation of 0.01%, 0.1%, 0.5% and 1% ophthalmic solutions of 8-hydroxycarteolol, statistically significant reduction of intraocular pressure was observed 8 and 24 hours after administration (p less than 0.05). It's maximum reduction of intraocular pressure, 1.6 +/- 0.5 mmHg was produced 24 hours after treatment by 0.1% solution. However, diurnal variation of IOP did not show a statistically significant difference.
Department of Ophthalmology, Yamanashi Medical College, Japan.
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Kato
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Sasaki
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Tsukahara
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000494:pharmacology; D000328:Adult; D002354:Carteolol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D003864:Depression, Chemical; D004311:Double-Blind Method; D005123:Eye / Q000187:drug effects*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D009799:Ocular Physiological Phenomena; D009883:Ophthalmic Solutions
D000319:Adrenergic beta-Antagonists; D009883:Ophthalmic Solutions; C060345:8-hydroxycarteolol; D002354:Carteolol