[Intralesional treatment of classical Kaposi sarcoma with interferon-alpha].
A 71-year-old female patient with classic Kaposi sarcoma (sarcoma idiopathicum haemorrhagicum multiplex) of the lower legs and one hand was treated with intralesional recombinant interferon alpha 2b. After 6 consecutive weeks of intratumoral injection of 1-3 million IU interferon-alpha 2b (Intron A) in three marked lesions, complete remission of intralesionally treated and of untreated tumours was observed. Even 9 months after treatment, the patient is still in complete remission. We conclude that this low dose and well-tolerated treatment schedule with interferon-alpha 2b is effective and a good alternative to radiation or chemotherapy in Kaposi sarcoma.
Hautklinik, Christian-Albrechts-Universität Kiel.
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A
Hauschild
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Petres-Dunsche
D000368:Aged; D016516:CD4-CD8 Ratio; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D005260:Female; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects / Q000276:immunology; D015552:Injections, Intralesional; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage*; D007958:Leukocyte Count / Q000187:drug effects; D011994:Recombinant Proteins; D012514:Sarcoma, Kaposi / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology / Q000628:therapy*
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins
Intraläsionäre Behandlung des klassischen Kaposi-Sarkoms mit Interferon alpha.