Determinants of total high density lipoprotein cholesterol and high density lipoprotein subfraction levels among Hispanic and non-Hispanic white persons with normal glucose tolerance: the San Luis Valley Diabetes Study.
Determinants of total high-density lipoprotein cholesterol (HDL-C) and HDL subfractions were assessed in Hispanic and non-Hispanic white persons (n = 932), aged 20-74 years, in the San Luis Valley, Colorado. Using multiple regression, BMI was negatively associated with HDL-C, HDL2-C, and HDL3-C in men and HDL-C and HDL3-C in women. Among females, current smokers had lower HDL-C and subfractions. Women on beta-blockers had lower HDL3-C levels. For both sexes, a positive association was observed between age and HDL-C and subfractions and physical activity with HDL-C and HDL3-C. Drinking alcohol (> or = 50 g/week) was associated with higher HDL-C and HDL3-C in both sexes and HDL2-C in women. The positive association of age and negative associations of the subscapular/triceps ratio and fasting insulin had consistent relationships with HDL-C, HDL2-C, and HDL3-C in men and women. Ethnicity was not significantly associated with HDL-C or subfractions after controlling for body fat distribution or fasting insulin.
Fulton-Kehoe
D L
DL
Department of Preventive Medicine & Biometrics, University of Colorado School of Medicine, Denver 80262.
Eckel
R H
RH
Shetterly
S M
SM
Hamman
R F
RF
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects; D000328:Adult; D000367:Age Factors; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects; D015992:Body Mass Index; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood*; D003120:Colorado / Q000453:epidemiology; D015986:Confounding Factors, Epidemiologic; D004232:Diuretics / Q000009:adverse effects; D015914:Estrogen Replacement Therapy / Q000009:adverse effects; D015444:Exercise; D005215:Fasting; D005260:Female; D005951:Glucose Tolerance Test; D006630:Hispanic or Latino; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood* / Q000453:epidemiology / Q000208:ethnology; D007328:Insulin / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood*; D053439:Lipoproteins, HDL2; D053440:Lipoproteins, HDL3; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012307:Risk Factors; D012737:Sex Factors; D012885:Skinfold Thickness; D012907:Smoking / Q000009:adverse effects; D044465:White People
D000319:Adrenergic beta-Antagonists; D008076:Cholesterol, HDL; D004232:Diuretics; D007328:Insulin; D008075:Lipoproteins, HDL; D053439:Lipoproteins, HDL2; D053440:Lipoproteins, HDL3