MPTP induced hemiparkinsonism in monkeys: behavioral, mechanographic, electromyographic and immunohistochemical studies.
A single infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine (MPTP) into the right internal carotid artery of Macaca mulatta monkeys resulted in akinesia and rigidity of the contralateral limb. The immunohistochemical study revealed a dramatic reduction in the number of TH-immunoreactive cells in the substantia nigra of the infused side (70-81%). After unilateral MPTP-treatment movement parameters and EMG activity were altered; the agonist muscle developed increased EMG activity associated with a shift of antagonist muscle activity. These results confirm that hemiparkinsonian monkeys are a valuable model of parkinsonism which can be useful in studies of movement disorder physiology and therapy of Parkinson's disease.
Benazzouz
A
A
Laboratoire de Neurophysiologie, CNRS URA 1200, Université de Bordeaux 2, France.
Gross
C
C
Dupont
J
J
Bioulac
B
B
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000031:analogs & derivatives*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D015259:Dopamine Agents; D004576:Electromyography / Q000187:drug effects; D007150:Immunohistochemistry; D007700:Kinetics; D008253:Macaca mulatta; D009132:Muscles / Q000473:pathology / Q000502:physiology; D010302:Parkinson Disease, Secondary / Q000139:chemically induced* / Q000473:pathology / Q000523:psychology
D015259:Dopamine Agents; C048977:1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine