Antisense oligonucleotides for therapeutic intervention.
Advances have been made in defining the best target sequences for use in antisense oligonucleotide technology, and new chemical derivatives of oligonucleotides are being investigated. Although the potential use of antisense oligonucleotide agents in the treatment of neoplastic, viral and parasitic diseases continues to be explored, they are not yet suitable for administration to humans for reasons that are discussed.
Eck
S L
SL
Howard Hughes Medical Institute, University of Michigan Medical Center, Department of Internal Medicine, Ann Arbor 48109-0650.
Nabel
G J
GJ
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D006801:Humans; D016376:Oligonucleotides, Antisense / Q000627:therapeutic use*; D010272:Parasitic Diseases / Q000188:drug therapy
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D016376:Oligonucleotides, Antisense