Systemic hyperthermia in the treatment of HIV-related Kaposi's sarcoma. A phase I study.
Ten Caucasian males with HIV-related Kaposi's sarcoma, a disseminated disease which is refractory to usual therapies, underwent a single session of systemic hyperthermia with maintenance of core temperatures at 42 degrees C for 1 h. One complete remission and 7 partial remissions were identified when assessed 30 days post-treatment. Two mixed responses were noted in patients whose tumors showed autocrine growth. At 60 days 2 of the 7 partial responders began to show tumor progression. The complete remission persisted at 120 days. Surrogate markers of HIV activity fell in all responding patients. In no patient was there evidence of HIV activation. No adverse effects of heating were noted on CMV retinitis. Hairy leukoplakia resolved with heating in all patients. CD4 counts showed no appreciable change in any of the 8 patients with a presenting CD4 count below 60. In the 2 patients who presented with a CD4 count above 400, CD4 counts rose dramatically following treatment. No deaths were noted in this phase I study. The use of systemic hyperthermia in treatment of HIV-related illness warrants further study.
Clinica Citta di Pavia, Italy.
K
K
Alonso
P
P
Pontiggia
C
C
Nardi
A
A
Sabato
F
F
Cuppone Curto
D000386:AIDS-Related Complex / Q000150:complications* / Q000276:immunology; D000328:Adult; D001772:Blood Cell Count; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D012514:Sarcoma, Kaposi / Q000150:complications* / Q000276:immunology / Q000628:therapy*