Expression of c-fos protein in serotonergic neurons of rat brainstem following electro-acupuncture.
The c-fos proto-oncogene encodes a nuclear phosphoprotein, Fos which has been proposed to be a "third messenger" coupling short term extracellular signals to long term alteration in cell function. Using double labeling immunocytochemistry, the present work demonstrated the co-localization of Fos protein and serotonin in the nucleus raphe dorsalis, nucleus raphe centralis superior and rostral ventromedial medulla. The results pose an interesting problem, the possible relation of Fos protein to the biosynthesis of serotonin, awaiting further investigation.
Dept. of Neurobiology, Shanghai Medical University, China.
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He
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Wang
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Gao
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Zhou
D000818:Animals; D001933:Brain Stem / Q000737:chemistry*; D015671:Electroacupuncture / Q000592:standards*; D005069:Evaluation Studies as Topic; D007150:Immunohistochemistry; D008297:Male; D016760:Proto-Oncogene Proteins c-fos / Q000737:chemistry* / Q000502:physiology; D011903:Raphe Nuclei / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000737:chemistry / Q000502:physiology
D016760:Proto-Oncogene Proteins c-fos; D012701:Serotonin