Trypanosomatidae codon usage and GC distribution.
A study of Trypanosomatidae GC distribution and codon usage is presented. The codon usage patterns in coincidence with the phylogenetical data are similar in Crithidia and Leishmania, whereas they are more divergent in Trypanosoma brucei and T. cruzi. The analysis of the GC mutational pressure in these organisms reveals that T. brucei, and to a lesser extent T. cruzi, have evolved towards a more balanced use of all bases, whereas Leishmania and Crithidia retain features of a primeval genetic apparatus. Tables with the approximated GC mutational pressure in homologous genes, and codon usage in Trypanosomatidae are presented.
Centro de Biología Celular, Universidad Central de Venezuela, Caracas.
G
G
Alonso
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P
Guevara
J L
JL
Ramirez
D000818:Animals; D001482:Base Composition; D005075:Biological Evolution; D003062:Codon; D003421:Crithidia / Q000235:genetics; D016054:DNA, Protozoan / Q000235:genetics*; D016678:Genome; D007891:Leishmania / Q000235:genetics; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D014349:Trypanosoma cruzi / Q000235:genetics; D014351:Trypanosomatina / Q000145:classification / Q000235:genetics*
D003062:Codon; D016054:DNA, Protozoan