A critical reappraisal of gastrointestinal complications of allogeneic bone marrow transplantation.
Gastrointestinal toxicity is a common early complication of allogeneic bone marrow transplants. Etiologies include mucosal damage from pretransplant conditioning, opportunistic infection, and graft-versus-host disease. Because the clinical, laboratory, radiographic, and histological findings of acute graft-versus-host disease are nonspecific, accurate diagnosis is difficult or impossible. We review the differential diagnosis of gastrointestinal complications of bone marrow transplants and implications for therapy.
Schiller
G J
GJ
Department of Medicine, UCLA School of Medicine 90024.
Gale
R P
RP
D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000276:immunology; D005753:Gastric Mucosa / Q000473:pathology; D005767:Gastrointestinal Diseases / Q000209:etiology*; D006086:Graft vs Host Disease / Q000276:immunology; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007413:Intestinal Mucosa / Q000473:pathology; D009894:Opportunistic Infections / Q000276:immunology; D014184:Transplantation, Homologous