Accelerated rejection of allografted rat liver perfused with anti-ICAM-1 monoclonal antibody.
Infusion of mouse anti-rat ICAM-1 into the portal vein of ACI rat liver graft before transplantation resulted in accelerated rejection by LEW recipients (2.9 +/- 2.5 days), when compared to the ACI liver grafts perfused with either Lactate-Ringer's solution (9.8 +/- 1.3) or anti-human ICAM-1 mAb (9.8 +/- 3.1). Histologic features of anti-rat ICAM-1 perfused grafts were spotty ischemic necrosis, whereas those of control grafts were marked cellular infiltration. These combined survival and histologic data suggest that the accelerated rejection may be mediated by vascular deterioration.
Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan.
T
T
Omura
H
H
Ishikura
Y
Y
Nakajima
C
C
Takahashi
J
J
Kimura
J
J
Uchino
T
T
Yoshiki
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D015815:Cell Adhesion Molecules / Q000276:immunology*; D006084:Graft Rejection / Q000139:chemically induced* / Q000209:etiology* / Q000473:pathology; D006085:Graft Survival / Q000187:drug effects; D018799:Intercellular Adhesion Molecule-1; D016031:Liver Transplantation / Q000276:immunology*; D010477:Perfusion; D051381:Rats; D011912:Rats, Inbred ACI; D014184:Transplantation, Homologous
D000911:Antibodies, Monoclonal; D015815:Cell Adhesion Molecules; D018799:Intercellular Adhesion Molecule-1