Adeno-associated virus vectors.
Adeno-associated virus is a human parvovirus that integrates its DNA genome into host cell chromosomes with very high efficiency. This suggests that adeno-associated virus may be a useful vector for human gene therapy. Interest in adeno-associated virus vectors increased greatly in the last year following reports that adeno-associated virus genome integration may be site specific and occur at preferred sites in the human genome. Several genes relevant to the treatment of genetic or infectious diseases have been expressed in adeno-associated virus vectors in vitro.
Carter
B J
BJ
Targeted Genetics Corporation, Seattle, Washington.
D001709:Biotechnology; D000229:Dependovirus / Q000235:genetics* / Q000254:growth & development; D015316:Genetic Therapy; D005822:Genetic Vectors; D016679:Genome, Viral; D006801:Humans; D012449:Safety; D016662:Virus Integration / Q000235:genetics