[Studies of cerebrospinal fluid diagnosis in Alzheimer's disease: a review of the literature and of current developments].
Studies into the value of examination of the cerebrospinal fluid (CSF) in diagnosing Alzheimer's disease are reviewed. The diagnostic utility of about 60 substances including CSF measures related to classical neurotransmitters, (neuro)peptides, proteins, amino-acids, trace elements, and constituents of senile plaques and neurofibrillary tangles is evaluated. Technical, methodological, and ethical issues relevant to this kind of studies are discussed. None of the CSF constituents studies so far, has a proven diagnostic utility. Increased knowledge concerning macromolecular changes in the brain and improved immunochemical techniques make the outlook for a diagnostic test for Alzheimer's disease on CSF promising.
Afdeling Neurologie, Academisch Medisch Centrum, Amsterdam.
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WA
van Gool
P A
PA
Bolhuis
D000544:Alzheimer Disease / Q000134:cerebrospinal fluid*; D000596:Amino Acids / Q000134:cerebrospinal fluid; D000682:Amyloid / Q000737:chemistry; D001923:Brain Chemistry; D002556:Cerebrospinal Fluid Proteins / Q000737:chemistry; D006801:Humans; D007477:Ions; D008670:Metals / Q000134:cerebrospinal fluid; D009479:Neuropeptides / Q000134:cerebrospinal fluid; D018377:Neurotransmitter Agents / Q000138:chemical synthesis
D000596:Amino Acids; D000682:Amyloid; D002556:Cerebrospinal Fluid Proteins; D007477:Ions; D008670:Metals; D009479:Neuropeptides; D018377:Neurotransmitter Agents
Onderzoek naar liquor-diagnostiek bij de ziekte van Alzheimer: een overzicht van de literatuur en van nieuwe ontwikkelingen.