Pancreatic cytoprotection: new approaches.
A brief report is given on the possible role of oxygen-derived free radicals and cholecystokinin in the pathogenesis of experimentally induced acute pancreatitis. Furthermore, use of scavengers (superoxide dismutase, catalase), CCK-receptor antagonists and somatostatin are discussed in the therapy of acute pancreatitis induced in animal models. It is suggested that both the term of direct pancreatic cytoprotection of the above-mentioned agents and the validity of the animal models used for induction of acute pancreatitis have to be reconsidered.
Papp
M
M
Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest.
D000818:Animals; D002766:Cholecystokinin / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D010182:Pancreatic Diseases / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy; D010195:Pancreatitis / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy
D005609:Free Radicals; D002766:Cholecystokinin