Inducible stable DNA replication in Escherichia coli uvr+ and uvr- cells, treated with genotoxic chemicals.
Inducible stable DNA replication (iSDR) provoked by a damaging treatment with MMS, MNU, MNNG, NFAA, NFN, 4NQO, NAL or MMC, was followed in both repair-competent E. coli PQ35 and its uvrA derivative E. coli PQ37. In contrast to SOS-inducible mutagenesis, which is more pronounced in excision-deficient cells, iSDR was more obvious in repair-competent cells. This may be due to special features of iSDR and need not indicate involvement of the uvrA gene product in it.
Department of Molecular Genetics, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
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Masek
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Sedliaková
D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology; D042462:4-Quinolones; D000179:Acrylates / Q000494:pharmacology; D000890:Anti-Infective Agents; D002701:Chloramphenicol / Q000494:pharmacology; D004261:DNA Replication / Q000187:drug effects*; D004926:Escherichia coli / Q000235:genetics*; D005663:Furans / Q000494:pharmacology; D008741:Methyl Methanesulfonate / Q000494:pharmacology; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D008770:Methylnitrosourea / Q000494:pharmacology; D016685:Mitomycin / Q000494:pharmacology; D009153:Mutagens / Q000494:pharmacology*; D009268:Nalidixic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D009574:Nitro Compounds / Q000494:pharmacology; D009581:Nitrofurans / Q000494:pharmacology
D042462:4-Quinolones; D000179:Acrylates; D000890:Anti-Infective Agents; D005663:Furans; D009153:Mutagens; D009574:Nitro Compounds; D009581:Nitrofurans; D008769:Methylnitronitrosoguanidine; D009268:Nalidixic Acid; C073116:5-nitro-2-furfuryl nitrate; D016685:Mitomycin; D015112:4-Nitroquinoline-1-oxide; C222012:nitrofurylacrylic acid; D002701:Chloramphenicol; D008770:Methylnitrosourea; C028959:citrated nalidixic acid; D008741:Methyl Methanesulfonate