Prostate-specific antigen and prostate-specific acid phosphatase in neuroendocrine cells of prostate cancer.
Prostate-specific antigen is a specific immunohistochemical marker of benign prostatic epithelium and prostate cancer. A subpopulation of neuroendocrine cells seen in 50% of cancers do not produce this protein marker. These cells appear to secrete prostate-specific acid phosphatase. This finding may explain the marked variation in serum prostate-specific antigen levels in all stages of prostate cancer.
Cohen
R J
RJ
Department of Anatomical Pathology, School of Pathology, South African Institute for Medical Research, Johannesburg.
Glezerson
G
G
Haffejee
Z
Z
D000135:Acid Phosphatase / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology; D053379:Chromogranin A; D002864:Chromogranins / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D009490:Neurosecretory Systems / Q000201:enzymology* / Q000473:pathology; D017430:Prostate-Specific Antigen; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D013194:Staining and Labeling
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D053379:Chromogranin A; D002864:Chromogranins; D000135:Acid Phosphatase; D017430:Prostate-Specific Antigen