The dynamics of MS-222 anaesthesia in a marine teleost (Pagrus auratus: Sparidae).
1. MS-222 anaesthesia of the marine teleost Pagrus auratus caused a dose-dependent elevation in haematocrit. 2. At 60 mg/l MS-222 the elevated haematocrit was fully accounted for by erythrocyte swelling, but at 100 mg/l red cell count also increased. 3. Uptake of anaesthetic in all tissues was rapid and the rate of onset of anaesthesia was dose-dependent. 4. Stage III level of anaesthesia (loss of equilibrium) was correlated with critical levels of MS-222 in the blood and brain. 5. The presence of acetylated derivatives of MS-222 in the blood demonstrated degradation of the anaesthetic, and high levels in the liver and kidney suggested that these organs were the sites of drug metabolism.
Ryan
S
S
Department of Zoology, University of Auckland, New Zealand.
D062365:Aminobenzoates / Q000493:pharmacokinetics*; D000777:Anesthetics / Q000493:pharmacokinetics*; D000818:Animals; D004906:Erythrocyte Count / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects; D006400:Hematocrit; D010473:Perciformes / Q000378:metabolism*
D062365:Aminobenzoates; D000777:Anesthetics; C003636:tricaine