An in vitro gas equilibration method for determination of chemical partition coefficients in fish.
1. A gas equilibration method for the determination of in vitro chemical partition coefficients in mammals was adapted for use with fish. 2. In vitro blood: water and tissue: blood partition coefficients were determined for three chlorinated ethanes in rainbow trout (Oncorhynchus mykiss). 3. In vitro partition coefficients accurately predicted chemical concentrations in tissues of exposed trout.
Hoffman
A D
AD
United States Environmental Protection Agency, Environmental Research Laboratory--Duluth, MN.
Bertelsen
S L
SL
Gargas
M L
ML
D000273:Adipose Tissue / Q000737:chemistry; D000818:Animals; D001784:Blood Gas Analysis; D004980:Ethane / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood; D006843:Hydrocarbons, Chlorinated / Q000032:analysis* / Q000097:blood; D066298:In Vitro Techniques; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D009132:Muscles / Q000737:chemistry; D009997:Osmotic Pressure; D014337:Trout
D006843:Hydrocarbons, Chlorinated; C016134:tetrachloroethane; C010182:hexachloroethane; D004980:Ethane; C016036:pentachloroethane