T-cell lymphoma and the virus-associated hemophagocytic syndrome.
A 20-month-old girl had a disorder that by both clinical and histologic criteria resembled the virus-associated hemophagocytic syndrome in the setting of Epstein-Barr virus infection. Subsequent investigation revealed histologic evidence of disseminated T-cell lymphoma. DNA hybridization studies displayed a monoclonal T-cell receptor beta chain rearrangement, in the absence of clonal immunoglobulin gene rearrangement, and a single band in the analysis for the fused termini of the Epstein-Barr virus genome. These results suggest the presence of a monoclonal population of T lymphocytes infected with Epstein-Barr virus. The diagnosis of lymphoma was confirmed at autopsy. The authors discuss the association of Epstein-Barr virus infection with the development of T-cell lymphoma and propose that the previous reports of virus-associated hemophagocytic syndrome include cases of unrecognized T-cell lymphoma.
Craig
F E
FE
University of Texas Health Science Center, San Antonio.
Clare
C N
CN
Sklar
J L
JL
Banks
P M
PM
D015139:Blotting, Southern; D004247:DNA; D005260:Female; D004854:Herpesvirus 4, Human; D015616:Histiocytosis, Non-Langerhans-Cell / Q000150:complications* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D007223:Infant; D008198:Lymph Nodes / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000473:pathology; D009693:Nucleic Acid Hybridization; D013194:Staining and Labeling; D014412:Tumor Virus Infections / Q000150:complications*
D004247:DNA