Aflatoxin and glutathione in domestic fowl (Gallus domesticus)--I. Glutathione elevation and attenuation by high dietary methionine.
1. Changes in hepatic and renal glutathione (GSH) and plasma aspartate aminotransferase (AST) following single or daily oral doses of aflatoxin B1 (AFB1, 2 mg/kg BW) or corn oil vehicle (1 ml/kg BW) were determined in male chickens (14-21-day-old). 2. Plasma AST and hepatic GSH increased 2 and 8 hr, respectively, following a single AFB1 dose. 3. Hepatic GSH continued to increase through 5 daily doses of AFB1, but there were no differences in AST levels on days 1-5. Feeding a diet containing 150% of NRC requirement for methionine attenuated the AFB1-induced increase in hepatic GSH. Renal GSH was unaffected by AFB1 or dietary treatment.
Department of Animal and Poultry Science, University of Arkansas, Fayetteville 72701.
K W
KW
Beers
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Nejad
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WG
Bottje
D016604:Aflatoxin B1 / Q000494:pharmacology*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002645:Chickens / Q000378:metabolism*; D004032:Diet; D005978:Glutathione / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008715:Methionine / Q000008:administration & dosage / Q000494:pharmacology*
D016604:Aflatoxin B1; D008715:Methionine; D001219:Aspartate Aminotransferases; D005978:Glutathione