Reversion of L-lysine inhibition of penicillin G biosynthesis by 6-oxopiperidine-2-carboxylic acid in Penicillium chrysogenum PQ-96.
6-Oxopiperidine-2-carboxylic acid (OCA; cyclic alpha-aminoadipic acid) reverses the L-lysine inhibition of penicillin G production by Penicillium chrysogenum PQ-96. The reaction probably depends on the recovery of L-alpha-aminoadipic acid for penicillin G production from OCA.
State Institute of Hygiene, Warsaw, Poland.
W
W
Kurzatkowski
J D
JD
Kurzatkowski
J
J
Filipek
J
J
Solecka
W
W
Kuryłowicz
D015074:2-Aminoadipic Acid / Q000494:pharmacology; D008239:Lysine / Q000494:pharmacology*; D010400:Penicillin G / Q000378:metabolism*; D010408:Penicillium chrysogenum / Q000187:drug effects / Q000378:metabolism*; D010875:Pipecolic Acids / Q000494:pharmacology*
C030878:6-oxopiperidine-2-carboxylic acid; D010875:Pipecolic Acids; D015074:2-Aminoadipic Acid; D008239:Lysine; D010400:Penicillin G