The role of hereditary factors in phenotypic variability of hormone levels in a population genetically adapted to the circumpolar environment.
The variability of plasma cortisol, T3, T4, TSH, and estradiol levels was studied in the North Khanty population genetically adapted to the extreme conditions of the North. Negative linear correlations of T3 and T4 levels with age were obtained. Cortisol, estradiol, and T3 levels showed nonlinear age dependency. T4 concentrations were significantly lower in August than February and November. The highest heritability estimate was shown for estradiol levels (44%). The relationships between genetic markers and hormone concentrations were studied.
Saljukov
V B
VB
Population Genetics Laboratory, Tomsk Scientific Center of the USSR Academy of Medical Sciences.
Lemza
S V
SV
Kucher
A N
AN
Puzyrev
V P
VP
D000328:Adult; D001110:Arctic Regions; D003081:Cold Climate; D004958:Estradiol / Q000097:blood; D005260:Female; D006728:Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D044468:Native Hawaiian or Pacific Islander / Q000235:genetics*; D010641:Phenotype; D044469:Racial Groups; D012426:Russia; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D006728:Hormones; D014284:Triiodothyronine; D004958:Estradiol; D013972:Thyrotropin; D013974:Thyroxine; D006854:Hydrocortisone