Failure to replicate linkage between chromosome 5q11-q13 markers and schizophrenia in 28 families.
Sherrington et al. (1988) reported linkage between markers located on the 5q11-q13 region of chromosome 5 and schizophrenia in five Icelandic and two British families. To date, however, all attempts to replicate the initial finding have failed. Using three markers of chromosome 5, we have studied 28 additional French pedigrees. When our data were analyzed both with parametric (i.e., lod scores) and nonparametric methods, we found no evidence of linkage. Thus, we were unable to replicate the earlier report by Sherrington et al.
Unité de Recherche d'Epidémiologie Génétique (INSERM U 155), Château de Longchamp, Gif sur Yvette, France.
D
D
Campion
T
T
d'Amato
H
H
Laklou
O
O
Sabate
M
M
Jay
M
M
Leboyer
A
A
Malafosse
P
P
Gorwood
M C
MC
Babron
D
D
Hillaire
D002895:Chromosomes, Human, Pair 5; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000235:genetics*
D005819:Genetic Markers