The effects of 7.5% NaCl/6% dextran 70 on coagulation and platelet aggregation in humans.
The combination solution of 7.5% NaCl/6% dextran 70 (HSD) administered IV gives hemodynamic improvement in the treatment of hemorrhagic hypotension. Since earlier dextran solutions were reported to interfere with blood coagulation, the effects of HSD on the prothrombin time (PT), the activated partial thromboplastin time (APTT), platelet aggregation, and platelet concentration were studied. The HSD mixed with human plasma (1:5 and 1:10) slightly prolonged PT, but had no effect on the APTT, compared with saline controls. The HSD also decreased human platelet aggregation at the 1:5 dilution. In separate mixing studies, the hypertonic saline component of HSD was associated with the prolongation of PT and decreased platelet aggregation. The data from these studies indicate that at its proposed therapeutic dose, HSD is expected to have minimal effect on blood coagulation.
Division of Military Trauma Research, Letterman Army Institute of Research, Presidio of San Francisco, CA 94129.
J R
JR
Hess
M A
MA
Dubick
J J
JJ
Summary
N R
NR
Bangal
C E
CE
Wade
D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects*; D003911:Dextrans / Q000494:pharmacology*; D006801:Humans; D006982:Hypertonic Solutions; D010314:Partial Thromboplastin Time; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D011517:Prothrombin Time; D012965:Sodium Chloride / Q000494:pharmacology*
D003911:Dextrans; D006982:Hypertonic Solutions; D010975:Platelet Aggregation Inhibitors; D012965:Sodium Chloride