Acute resistant asthma caused by excessive beta-2-adrenoceptor agonist inhalation and reversed by inhalation of beclomethasone.
With the aim of devising an improved beta 2-agonist treatment regimen for patients presenting with acute severe resistant asthma, a double-blind, placebo-controlled randomised study of the effect of fenoterol and beclomethasone inhalations was done in 40 patients. Fenoterol inhalations had minimal effect in acute resistant asthma, but significant improvement was obtained when beclomethasone inhalations were given before fenoterol inhalations. Sequential beclomethasone and fenoterol inhalations can therefore be used as a preliminary emergency treatment for these patients.
Department of Internal Medicine, University of the Orange Free State, Bloemfontein.
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Pansegrouw
D000280:Administration, Inhalation; D000318:Adrenergic beta-Agonists / Q000009:adverse effects*; D001249:Asthma / Q000209:etiology*; D001507:Beclomethasone / Q000008:administration & dosage*; D004311:Double-Blind Method; D004351:Drug Resistance; D005280:Fenoterol / Q000009:adverse effects; D006801:Humans; D012129:Respiratory Function Tests
D000318:Adrenergic beta-Agonists; D005280:Fenoterol; D001507:Beclomethasone