Taxol: quantitative internuclear proton-proton distances in CDCl3 solution from nOe data: 2D nmr ROESY buildup rates at 500 MHz.
Quantitative nmr internuclear proton-proton distance measurements obtained by observation of the initial buildup rates of nOe's in 2D ROESY spectra of taxol [1] in CDCl3 are reported. A comparison to the X-ray crystal structure of taxotere [2] is made, and the results are discussed in terms of previous studies of structure-activity relationships.
Program Resources, Inc./DynCorp, NCI-Frederick Cancer Research and Development Center, Maryland 21702.
B D
BD
Hilton
G N
GN
Chmurny
G M
GM
Muschik
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D002725:Chloroform; D003461:Crystallography; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D017239:Paclitaxel / Q000737:chemistry*; D014961:X-Ray Diffraction
D000972:Antineoplastic Agents, Phytogenic; D002725:Chloroform; D017239:Paclitaxel