Studies on Formosan soft corals. II. Cytotoxic cembranolides from the soft coral Lobophytum michaelae.
Bioactivity-guided fractionation of a CHCl3 extract of the soft coral Lobophytum michaelae afforded a new cytotoxic cembranolide, lobomichaolide (1), and a known cytotoxic cembranolide, crassolide (2). The structure of 1 was determined by spectral and X-ray crystallographic analysis.
Wang
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Duh
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Wu
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YC
Wang
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Cheng
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MC
Soong
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Fang
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D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003063:Cnidaria / Q000737:chemistry* / Q000502:physiology; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D007624:KB Cells; D007941:Leukemia P388 / Q000188:drug therapy; D014407:Tumor Cells, Cultured; D014961:X-Ray Diffraction
D000970:Antineoplastic Agents; D003603:Cytotoxins; D004224:Diterpenes; C078545:lobomichaolide; C078544:crassolide