Effects of pressure and gaseous anesthetics on the aggregation of human blood platelets and marine sponge cells: similarities in responses.
1. Aggregation of blood platelets and marine sponge cells was inhibited by nitrous oxide (N2O) and helium (He) at elevated pressure but potentiated by xenon (Xe) despite the fact that Xe and N2O are equipotent gaseous anesthetics. 2. The above aggregations are dependent on an extracellular source of calcium. 3. Platelet aggregation induced by phorbol myristate is independent of extracellular calcium and was inhibited by both N2O and Xe and by high pressures of He. 4. The results argue against a common mechanism for Xe and N2O and suggest that pressure may affect calcium interactions with binding site.
Department of Pharmacology and Toxicology, University of Western Ontario, London, Canada.
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RB
Philp
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Arora
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K
Forsberg
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DJ
McIver
D000328:Adult; D000777:Anesthetics; D000818:Animals; D005260:Female; D005740:Gases; D006371:Helium; D006801:Humans; D008297:Male; D008875:Middle Aged; D009609:Nitrous Oxide; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D011161:Porifera / Q000166:cytology*; D011312:Pressure; D014978:Xenon
D000777:Anesthetics; D005740:Gases; D010975:Platelet Aggregation Inhibitors; D006371:Helium; D014978:Xenon; D009609:Nitrous Oxide