Immunomodulatory effects of fusarochromanones TDP-1 and TDP-2.
An in vitro peripheral lymphocyte blastogenesis system was used to investigate the biological activities of the fungal toxin fusarochromanone (TDP-1) and its monoacetyl derivative TDP-2. Briefly, cultures of human or bovine peripheral lymphocytes were exposed to TDP-1 or TDP-2 and a mitogen (PHA, Con A or PWM). After a standard incubation time, cell proliferation was quantified using the MTT bioassay. Human and bovine lymphocyte proliferation was inhibited by high concentrations of TDP-1; however, bovine lymphocyte proliferation was significantly increased at low concentrations of TDP-1. TDP-2 has similar but less pronounced effects on lymphocyte proliferation.
Istituto Tossine e Micotossine da Parassiti Vegetali, C.N.R., Bari, Italy.
F
F
Minervini
G
G
Lucivero
A
A
Visconti
C
C
Bottalico
D000596:Amino Acids / Q000633:toxicity*; D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D002867:Chromones / Q000633:toxicity*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D009183:Mycotoxins / Q000633:toxicity*
D000596:Amino Acids; D002867:Chromones; D009183:Mycotoxins; C087004:3'-N-acetylfusarochromanone; C054523:fusarochromanone