[Skin and laboratory tests: comparison of the epicutaneous patch test with the TTL and LIF tests in the diagnosis of medicamentous allergic contact dermatitis].
We investigated 158 patients from 15 to 82 years of age with clinically evident contact dermatitis, diagnosed at the Department for Allergic Diseases Investigations-Clinic for Dermatovenerological Diseases, Medical Faculty in Novi Sad, during the period of 1 year. We performed patch-epicutaneous test, lymphocyte transformation test (TTL) and leukocyte migration inhibition test (LIF). Among the 130 (82.2%) patients suffering from contact dermatitis, with the positive patch tests to commercial or standard battery epicutaneous allergens, 26 (20%) had at least one positive patch test to the medicament. In these cases contact allergic medicamentous dermatitis (SAMD) was proved by positive clinical and allergic investigations. In only one case, patch test was negative, with booth the TTL and LIF test positive. Among the medicaments TTL and LIF tested, antibiotics were the most frequent in 9 (34.61%) cases, analgetics were found in 6 (23.08%). Professional contact allergy to medicaments has been estimated in 5 patients (19.23%). According to the obtained results and statistic findings, relationships between the two variables-TTL and patch test, and LIF and patch test, were estimated due to the contact allergy to medicaments. Both of them were low and negative without statistic significance. Patch test remains to be the irreplaceable test with regard to CAMD.
Klinika za infektivne o dermatoveneroloske bolesti, Hajduk Veljkova, Medicinski fakultet, Novi Sad.
M
M
Jovanović
M
M
Poljacki
J
J
Milakov
V
V
Duran
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002464:Cell Migration Inhibition; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000209:etiology; D003875:Drug Eruptions / Q000175:diagnosis*; D006801:Humans; D007159:Immunologic Tests; D008213:Lymphocyte Activation; D008875:Middle Aged; D010328:Patch Tests
Kozni i laboratorijski test: poredenje epikutanog patch testa sa TTL i LIF testom u dijagnostici medikamentoznih alergijskih kontaktnih dermatitisa.