Effect of exogenous copper on lipid peroxidation in rat hepatocytes. Possible involvement of protein kinase C.
We have investigated the direct effect of copper on malondialdehyde formation in rat isolated hepatocytes. Copper was found to decrease the cell viability with concomitant production of malondialdehyde in a time related manner. In addition the protein kinase C activator, PMA, was found to have a synergistic effect with copper on rat hepatocytes. These results indicate that protein kinase C may be important in mediating hepatotoxicity after exposure to copper.
Mudassar
S
S
Department of Pediatrics, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Andrabi
K I
KI
Khullar
M
M
Ganguly
N K
NK
Walia
B N
BN
D000818:Animals; D003300:Copper / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects*; D008315:Malondialdehyde / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats
D008315:Malondialdehyde; D003300:Copper; D011493:Protein Kinase C