Demonstration of HTLV-related proviral DNA sequences and antibodies reactive with HTLV internal proteins in an Hungarian patient with Sézary syndrome.
DNA sequences distantly related to the proviral DNA of HTLV-I were found in the leukemic cells of a Hungarian patient suffering from Sézary syndrome. Serum samples from the patient contained antibodies reactive with the internal core polypeptides of HTLV-I and HTLV-II, but not with the env gene encoded type-specific HTLV antigens. The husband and daughter of the patient also had antibodies of the same specificity. These findings suggest the presence of a virus distantly related to HTLV-I and HTLV-II.
Kiss
J
J
Institute of Microbiology, University Medical School, Debrecen, Hungary.
Kiss
A
A
Tóth
F D
FD
Surányi
P
P
Szegedi
A
A
Rak
K
K
D000328:Adult; D003429:Cross Reactions; D004279:DNA, Viral / Q000032:analysis*; D017977:Deltaretrovirus / Q000235:genetics*; D015485:Deltaretrovirus Antigens / Q000276:immunology; D005260:Female; D015481:HTLV-I Antibodies / Q000032:analysis*; D015482:HTLV-II Antibodies / Q000032:analysis*; D006801:Humans; D011533:Proviruses / Q000235:genetics*; D012751:Sezary Syndrome / Q000276:immunology / Q000382:microbiology*; D014758:Viral Core Proteins / Q000276:immunology*
D004279:DNA, Viral; D015485:Deltaretrovirus Antigens; D015481:HTLV-I Antibodies; D015482:HTLV-II Antibodies; D014758:Viral Core Proteins