[The effect of fenazepam on the humoral immune response in secondary immunodeficiency].
A single administration of phenazepam (2.5 mg/kg) enhances the synthesis of antibodies after immunization with different vaccines. Phenazepam restores antibody formation in immunodeficiency induced by intoxication. The immunostimulating effect of phenazepam is linked with an increase in the capacity of macrophages for inducing humoral immune response and a rise in the number of antibody-producing cells in the spleen.
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Zabrodskiĭ
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D000907:Antibodies, Bacterial / Q000097:blood / Q000187:drug effects; D000917:Antibody Formation / Q000187:drug effects; D001138:Armin / Q000506:poisoning; D001428:Bacterial Vaccines / Q000276:immunology; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology*; D007114:Immunization; D007153:Immunologic Deficiency Syndromes / Q000139:chemically induced / Q000276:immunology*; D011041:Poisoning / Q000150:complications / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000276:Adjuvants, Immunologic; D014151:Anti-Anxiety Agents; D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam; D001138:Armin
Vliianie fenazepama na gumoral'nyĭ immunnyĭ otvet pri vtorichnom immunodefitsite.