No association or linkage with HLA-DR or -DQ genes in south Indians with pulmonary tuberculosis.
Studies of the HLA class II genes were performed in patients and multiple families with pulmonary tuberculosis from South India to seek any association of disease susceptibility with an individual allele or haplotype. TaqI RFLP analysis of HLA-DRB, -DQA and -DQB genes was done in 38 patients and 36 healthy control subjects. No significant association with any particular allele or haplotype was obtained. Linkage analysis performed in 12 families and haplotype sharing analysis in 9 families showed that the genetic susceptibility to pulmonary tuberculosis was not linked to the HLA region. The results suggest that the RFLP patterns of HLA class II genes DRB, DQA and DQB are not associated with susceptibility to pulmonary tuberculosis and that the genes controlling susceptibility or resistance may be located outside the HLA region.
Center for BioTechnology, Karolinska Institute, Huddinge, Sweden.
C B
CB
Sanjeevi
P R
PR
Narayanan
R
R
Prabakar
N
N
Charles
B E
BE
Thomas
R
R
Balasubramaniam
O
O
Olerup
D015139:Blotting, Southern; D004198:Disease Susceptibility; D005260:Female; D005802:Genes, MHC Class II / Q000502:physiology*; D008040:Genetic Linkage / Q000502:physiology; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006801:Humans; D007194:India / Q000208:ethnology; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D014397:Tuberculosis, Pulmonary / Q000235:genetics* / Q000276:immunology
D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens