An analysis of hypotensive effect of synthetic oxytocin in rabbit.
Intravenous injection of synthetic oxytocin (Syntocinon) causes a fall of blood pressure in rabbit. The hypotensive response was potentiated after vagotomy and atropine. Beta-adrenergic and 5-HT blockers reduced the hypotensive response to oxytocin. Hypotensive response of oxytocin in rabbit involves two factors, activation of beta-adrenergic receptor and release of 5-HT.
Ansari
K U
KU
Department of Pharmacology, M.L.N. Medical College Allahabad.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D008297:Male; D010121:Oxytocin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011817:Rabbits; D012702:Serotonin Antagonists / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D012702:Serotonin Antagonists; D010121:Oxytocin; D001285:Atropine