Dopamine D2 receptor antagonists induce immediate early genes in the rat striatum.
The acute effects of dopamine D2 antagonists and agonists on the expression of c-jun, zif-268, ETR101 and c-fos in the rat striatum were studied. A single injection IP of haloperidol (2 mg/kg) or sulpiride (100 mg/kg) produced a rapid and transient increase in c-jun, zif-268 and c-fos mRNA. ETR101 was not activated. These inductions were dose dependent and were specifically blocked by pretreatment with a D2 agonist (1 mg/kg quinelorane). Quinelorane alone had no effect. Thus, dopamine D2 receptors inhibit the expression of a particular set of immediate early genes in the striatum.
Laboratoire de Neurobiologie Moléculaire des Interactions Cellulaires, (UPR 416 du CNRS), Centre de Neurochimie, Strasbourg, France.
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D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D001345:Autoradiography; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D065127:Dopamine D2 Receptor Antagonists; D005796:Genes / Q000187:drug effects*; D016762:Genes, fos; D016758:Genes, jun; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar
D014150:Antipsychotic Agents; D065127:Dopamine D2 Receptor Antagonists; D012333:RNA, Messenger