Treatment of acute variceal bleeding.
Once the bleeding patient has been resuscitated and the diagnosis of acute variceal hemorrhage established by endoscopy, emergency injection sclerotherapy should be employed as the therapeutic option of choice. Endoscopic band ligation is a promising new technique that may prove to be as effective as sclerotherapy, with fewer complications. Pharmacologic treatment (with vasopressin and nitroglycerin) and balloon tamponade remain important alternative treatments, both as empiric temporizing therapy before sclerotherapy can be arranged and in the approximately 30% of patients who continue to bleed after a single sclerotherapy session. Continued bleeding in many of these patients can be controlled with a second session of sclerotherapy. If active acute bleeding persists after two sclerotherapy treatments, treatment should be considered a failure. Some of these patients may be suitable for surgical treatment with either staple-gun transection of the esophagus or emergency portacaval shunting.
Matloff
D S
DS
Tufts University School of Medicine, Boston, Massachusetts.
D000208:Acute Disease; D021721:Balloon Occlusion; D002404:Catheterization; D004334:Drug Administration Schedule; D004630:Emergencies; D016099:Endoscopy, Gastrointestinal; D004932:Esophageal and Gastric Varices / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications; D008026:Ligation; D005996:Nitroglycerin / Q000008:administration & dosage / Q000627:therapeutic use; D011167:Portacaval Shunt, Surgical; D015911:Sclerotherapy / Q000009:adverse effects / Q000379:methods; D013004:Somatostatin / Q000627:therapeutic use; D014667:Vasopressins / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use
D014667:Vasopressins; D013004:Somatostatin; D005996:Nitroglycerin