Biogenic amines in the guinea pig endocrine pancreas.
Pancreata of guinea-pigs were investigated for the presence and cellular distribution of biogenic amines. Out of the established endocrine cell types only insulin (B-) cells contained immunoreactivity for serotonin and noradrenaline. However, the B-cells' content of both amines was quite variable. Serotonin was also confined to enterochromaffin (EC-) cells. No immunoreactivity for dopamine or histamine was present in any islet cell. Treatment of guinea-pigs with Ro-4-4602 led to a marked decrease of serotonin and noradrenaline in pancreatic endocrine cells. The present findings suggest that serotonin and noradrenaline are involved in the function of the endocrine pancreas, particularly of islet B-cells.
Cetin
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Abt. Anatomie 1, Medizinische Hochschule Hannover, Federal Republic of Germany.
D000818:Animals; D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D001545:Benserazide / Q000008:administration & dosage / Q000494:pharmacology; D002395:Catecholamines / Q000032:analysis*; D005934:Glucagon / Q000032:analysis; D006168:Guinea Pigs; D007124:Immunoenzyme Techniques; D007274:Injections, Intraperitoneal; D007328:Insulin / Q000032:analysis; D007515:Islets of Langerhans / Q000737:chemistry*; D008297:Male; D013004:Somatostatin / Q000032:analysis
D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D002395:Catecholamines; D007328:Insulin; D013004:Somatostatin; D001545:Benserazide; D005934:Glucagon