The effects of m-octopamine on salivary flow rates and protein secretion by rat submandibular glands.
1. m-Octopamine given i.v. or i.p. was a potent sialogogue for rat salivary glands. 2. Salivation in response to i.v. m-octopamine was completely abolished by prazosin and phenoxybenzamine. 3. The alpha-type of proteins were secreted in response to all doses of i.v. and i.p. m-octopamine and these were converted into the beta-type with prazosin, but not with yohimbine. 4. m-Octopamine stimulated both alpha- and beta-adrenoceptors and was a much more selective alpha 1-agonist than was the p-isomer.
Department of Oral Biochemistry, Fukuoka Dental College, Japan.
A
A
Okina
K
K
Abe
H
H
Inuzuka
T
T
Yano
T
T
Okina
T
T
Nakashima
T
T
Nishiura
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001340:Autonomic Nerve Block; D002395:Catecholamines / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008297:Male; D009655:Octopamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012471:Salivary Proteins and Peptides / Q000378:metabolism*; D012472:Salivation / Q000187:drug effects*; D013363:Submandibular Gland / Q000187:drug effects* / Q000378:metabolism; D014439:Tyramine / Q000494:pharmacology; D015016:Yohimbine / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D002395:Catecholamines; D012471:Salivary Proteins and Peptides; D009655:Octopamine; D015016:Yohimbine; C005310:norfenefrine; D000242:Cyclic AMP; D006152:Cyclic GMP; D014439:Tyramine