Effects of the association of alpha and beta-blocking agents in glaucoma.
Twenty patients with POAG and early visual field changes, already under treatment with 0.5% timolol were randomly assigned to additional topical treatment with 0.5% dapiprazole or placebo. After six months of treatment no differences were observed between the groups for what concerns visual field. After six months of treatment visual field, visual flicker discrimination and contrast sensitivity proved to be constant without differences between the groups. On the contrary, mean IOP was found to be significantly lower in the dapiprazole group.
Department of Ophthalmology, University of Verona, Italy.
L
L
Bonomi
G
G
Marchini
M
M
Marraffa
I
I
De Franco
S
S
Perfetti
E
E
Ferri
D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D000368:Aged; D015350:Contrast Sensitivity / Q000187:drug effects; D004311:Double-Blind Method; D004338:Drug Combinations; D005425:Flicker Fusion / Q000187:drug effects; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008875:Middle Aged; D009883:Ophthalmic Solutions; D010879:Piperazines; D010919:Placebos; D013999:Timolol / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*; D014794:Visual Fields / Q000187:drug effects
D000317:Adrenergic alpha-Antagonists; D004338:Drug Combinations; D009883:Ophthalmic Solutions; D010879:Piperazines; D010919:Placebos; D014230:Triazoles; C035289:dapiprazole; D013999:Timolol