Effects of a benzodiazepine on the muscle membrane architecture of the rat diaphragm. A freeze-fracture study.
1. Midazolam increases, stimulation-independently, the amount of intermembraneous particles on the sarcolemma of the muscle fibres of the diaphragm. 2. Midazolam does not affect the amount of orthogonal arrays of particles on the sarcolemma. 3. Possible mechanisms for the action of midazolam are discussed.
Department of Electron Microscopy, University of Amsterdam, Faculty of Medicine, The Netherlands.
J
J
van Marle
J J
JJ
Eigenhuis
A
A
Bokkinga
M A
MA
Cheung Tan Hé
R P
RP
van Slagmaat
D000818:Animals; D003964:Diaphragm / Q000187:drug effects* / Q000648:ultrastructure; D005260:Female; D005614:Freeze Fracturing; D066298:In Vitro Techniques; D008566:Membranes / Q000187:drug effects / Q000648:ultrastructure; D008874:Midazolam / Q000494:pharmacology*; D051381:Rats
D008874:Midazolam