[A hypothesis of the possible mechanism of the action of analgesic agents at the neuronal level].
The opiate analgetic promedol and non-opiate analgetics analgin, clonidine, baclofen, tolibut, vasopressin and calcitonin given in adequate doses block the inward electrosensitive sodium transmembrane ionic current of neurons. Like some drugs which do not exhibit any analgetic effect, promedol, analgin, clonidine, vasopressin and calcitonin also block the electrosensitive delayed potassium current. It is assumed that the blocking of the sodium ionic current may be one of the potential analgetic mechanisms at the neuronal level.
I Iu
IIu
Artem'ev
Iu A
IuA
Darinskiĭ
M I
MI
Sologub
D000700:Analgesics / Q000494:pharmacology*; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000502:physiology; D004558:Electric Stimulation; D004594:Electrophysiology; D066298:In Vitro Techniques; D008195:Lymnaea; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology; D015222:Sodium Channels / Q000187:drug effects / Q000502:physiology
D000700:Analgesics; D000701:Analgesics, Opioid; D015221:Potassium Channels; D015222:Sodium Channels
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