[Mucosa-associated immune system in HIV-1 infection. T-cell subpopulations compared in different segments of the gastrointestinal tract].
T-lymphocyte subsets in duodenal, ileal, coecal, colonal, sigmoidal, and rectal lamina propria were determined in order to compare the distribution of CD2+, CD4+, and CD8+ cell subsets as well as the CD4/CD8 ratio in six different compartments of the gastrointestinal tract. In both HIV1-infected and not HIV1-infected patients, no differences in the distribution of T-lymphocyte subsets could be noted between the compartments examined. The HIV1-infected patients showed a decrease of CD4+ helper cells and CD4/CD8 ratio and an increase of CD8+ suppressor/cytotoxic cells in all examined segments. In terms of lamina propria T-lymphocyte subsets, the intestinal immune system seems to react to HIV1-infection homogenously.
Franzen
C
C
Klinik I für Innere Medizin, Universität zu Köln.
Salzberger
B
B
Fätkenheuer
G
G
Eidt
S
S
Schrappe
M
M
D000328:Adult; D000368:Aged; D016516:CD4-CD8 Ratio; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000276:immunology*
Mukosaassoziiertes Immunsystem bei HIV1-Infektion. T-Zell-Subpopulationen im Vergleich verschiedener Abschnitte des Gastrointestinaltrakts.