Quantitative determination of zetidoline, a new antipsychotic agent, in human blood plasma and saliva using capillary gas chromatograph-mass spectrometry.
A specific and sensitive assay is described. Zetidoline is extracted with ethyl ether from 1 ml of plasma or saliva added with the internal standard. The extract is carefully purified and injected into a gas chromatography-mass spectrometry system equipped with a crosslinked capillary column and operated in single ion monitoring mode by electron impact. Quantitative response is linear in the range 2-50 ng/ml. The detection limit is 1 ng/ml.
Landi
M
M
MMDRI, Lepetit Research Center, Gerenzano (VA), Italy.
Dubini
E
E
Zerilli
L F
LF
D014150:Antipsychotic Agents / Q000032:analysis* / Q000097:blood; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007093:Imidazoles / Q000032:analysis* / Q000097:blood; D012463:Saliva / Q000737:chemistry*
D014150:Antipsychotic Agents; D007093:Imidazoles; C027277:zetidoline