Accumulation of polyvinylpyrrolidone within the inflamed paws of adjuvant-induced arthritic rats.
125I-Labelled polyvinylpyrrolidone ([125I]PVP) of a range of molecular weights (mol. wt 10, 40 and 360 kDa) was injected i.v. into adjuvant-induced arthritic and normal rats and the blood clearance and tissue distribution of the polymers determined. The half-life of PVP in the circulation increased with increasing mol. wt; 10, 40 and 360 kDa polymers had mean terminal half-lives of 2.2, 6.9 and 16.4 h, respectively. Tissue uptake was also found to be mol. wt dependent, the largest PVP molecule accumulating to a greater extent in the spleen, liver, lungs and paws in both normal and arthritic rats (P less than 0.01) than the two lower mol. wt polymers. Accumulation of the polymer in inflamed paws (g tissue)-1 greatly exceeded that of normal paws (P less than 0.01). This difference was particularly noticeable with 360 kDa PVP, where arthritic paws amassed 7 times more PVP than normal paws.
Welsh School of Pharmacy, University of Wales College of Cardiff, UK.
L
L
Seale
W G
WG
Love
N
N
Amos
B D
BD
Williams
I W
IW
Kellaway
D000818:Animals; D001169:Arthritis, Experimental / Q000378:metabolism*; D002850:Chromatography, Gel; D005260:Female; D005528:Foot / Q000502:physiology*; D006207:Half-Life; D007457:Iodine Radioisotopes; D011205:Povidone / Q000737:chemistry / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D007457:Iodine Radioisotopes; D011205:Povidone