Regulation of transendothelial transport in the cerebral microvessels: the role of second messengers-generating systems.
Different elements of the intracellular signaling messenger systems have been detected in the course of our studies in the cerebral endothelial cells. It has been shown that the synthesizing enzymes of and substrate proteins for the second messenger molecules are present in the cerebral endothelial cells, and their activity and/or amount can change in pathological circumstances, i.e., during the formation of brain oedema. Pharmacological treatments interfering with the second messenger systems proved to be effective in the prevention of brain oedema formation.
Joó
F
F
Laboratory of Molecular Neurobiology, Biological Research Center, Szeged, Hungary.
Lengyel
I
I
Kovács
J
J
Penke
B
B
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000502:physiology; D001929:Brain Edema / Q000503:physiopathology; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D002560:Cerebrovascular Circulation; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D004730:Endothelium, Vascular / Q000502:physiology*; D006162:Guanylate Cyclase / Q000378:metabolism; D008833:Microcirculation / Q000502:physiology*; D011494:Protein Kinases / Q000378:metabolism; D015290:Second Messenger Systems
D000242:Cyclic AMP; D011494:Protein Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D000262:Adenylyl Cyclases; D006162:Guanylate Cyclase; D006152:Cyclic GMP