Induction by cortisol of aminopeptidases production from the human placenta in tissue culture.
Human placental aminopeptidase M and A and post-proline endopeptidase are known to act as degrading enzymes of bioactive peptides such as angiotensin II, oxytocin and endogenous opioids. We tested the effects of cortisol on the activities of human placental aminopeptidase A and M and post-proline endopeptidase using short-cultured placental tissues. From 34.5 nM to 3.45 microM of cortisol significantly increased the activities of 3 enzymes. Our present data suggest a possible important role of cortisol in the growth of human placenta via induction of placental aminopeptidases.
Yasuda
Y
Y
Department of Obstetrics and Gynaecology, Nagoya University School of Medicine, Japan.
Mizutani
S
S
Kurauchi
O
O
Kasugai
M
M
Narita
O
O
Tomoda
Y
Y
D000626:Aminopeptidases / Q000096:biosynthesis*; D018826:CD13 Antigens; D046508:Culture Techniques; D005260:Female; D043384:Glutamyl Aminopeptidase; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D010920:Placenta / Q000187:drug effects / Q000201:enzymology*; D011247:Pregnancy; D000085822:Prolyl Oligopeptidases; D012697:Serine Endopeptidases / Q000096:biosynthesis*
D000626:Aminopeptidases; D018826:CD13 Antigens; D043384:Glutamyl Aminopeptidase; D012697:Serine Endopeptidases; C000705287:PREPL protein, human; D000085822:Prolyl Oligopeptidases; D006854:Hydrocortisone