The influence of preculture on the process performance of penicillin V production in a 100-l air-lift tower loop reactor.
The influence of stirrer speed in the third preculture on the performance of penicillin V production by Penicillium chrysogenum in complex medium in a 100-l air-lift tower loop reactor was investigated. The process performance in the main culture was improved by increasing the stirrer speed from 500 to 750 rpm: the pellet size was reduced to half, the cell growth was influenced only slightly, but the production phase was extended considerably, and the final penicillin concentration was increased from 5.1 g l-1 to 10.4 g l-1.
Institut für Technische Chemie, Universität Hannover, Federal Republic of Germany.
J
J
Möller
J
J
Niehoff
S
S
Hotop
M
M
Dors
K
K
Schügerl
D002245:Carbon Dioxide / Q000378:metabolism; D003470:Culture Media; D006863:Hydrogen-Ion Concentration; D010100:Oxygen / Q000494:pharmacology; D010404:Penicillin V / Q000378:metabolism*; D010408:Penicillium chrysogenum / Q000254:growth & development / Q000378:metabolism*
D003470:Culture Media; D002245:Carbon Dioxide; D010100:Oxygen; D010404:Penicillin V