Effects of L-156,602, a C5a receptor antagonist, on mouse experimental models of inflammation.
L-156,602, a C5a receptor antagonist, was found as an immunosuppressant with preferential effects on delayed-type hypersensitivity (DTH) in our screening program and it was shown that L-156,602 suppressed the efferent phase of DTH. Here, we tested its effects on experimental models of inflammation induced in mice. L-156,602 did not suppress serotonin- and carrageenan- induced inflammation while it completely suppressed concanavalin A-induced inflammation 4 h after elicitation. The inflammation appeared 24 h after the elicitation with concanavalin A and it was significantly suppressed by L-156,602. Muramyl dipeptide (MDP)-induced acute joint inflammation was also significantly suppressed by L-156,602. These results demonstrated the unique immunomodulating properties of L-156,602 in mouse experimental models of inflammation.
Tsuji
R F
RF
Noda Institute for Scientific Research, Chiba, Japan.
Magae
J
J
Nagai
K
K
Yamasaki
M
M
D000818:Animals; D002351:Carrageenan; D015936:Complement C5a / Q000037:antagonists & inhibitors*; D003208:Concanavalin A; D005260:Female; D007249:Inflammation / Q000139:chemically induced / Q000503:physiopathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D008819:Mice, Nude; D016513:Mice, SCID; D010456:Peptides, Cyclic / Q000494:pharmacology*; D044087:Receptor, Anaphylatoxin C5a; D011951:Receptors, Complement / Q000037:antagonists & inhibitors*; D012701:Serotonin
D010456:Peptides, Cyclic; D044087:Receptor, Anaphylatoxin C5a; D011951:Receptors, Complement; C051485:PD 124966; D003208:Concanavalin A; D012701:Serotonin; D015936:Complement C5a; D002351:Carrageenan