Molecular cytogenetics: diagnosis and prognostic assessment.
This review describes molecular cytogenetic techniques for detection and characterization of genetic aberrations associated with human disease. The techniques of fluorescence in situ hybridization, primed in situ labeling and comparative genome hybridization are described, as are probes for repeated sequences, whole chromosomes and specific loci. Also reviewed are applications of these technologies to pre- and neonatal diagnosis and to the characterization of human malignancies.
Gray
J W
JW
Department of Laboratory Medicine, University of California, San Francisco 94143-0808.
Kallioniemi
A
A
Kallioniemi
O
O
Pallavicini
M
M
Waldman
F
F
Pinkel
D
D
D001483:Base Sequence; D003582:Cytogenetics / Q000379:methods*; D004247:DNA / Q000235:genetics; D005260:Female; D030342:Genetic Diseases, Inborn / Q000175:diagnosis* / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D007938:Leukemia / Q000175:diagnosis* / Q000235:genetics; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics; D011247:Pregnancy; D011296:Prenatal Diagnosis; D011379:Prognosis
D004247:DNA