Racial differences in coagulation studies in stroke.
Racial differences in stroke are known to exist with persons in the black race having a higher morbidity, mortality and incidence of stroke compared to whites. We evaluated coagulation factors in black and white stroke patients and compared the results between races. D-dimer was elevated more frequently in blacks than whites to a statistically significant degree. There were non-significant trends for blacks to have a positive lupus anticoagulant, low protein C and protein S, higher platelet factor 4, and hyporesponsive platelets to 10 microM epinephrine. The significance of these findings in understanding racial differences in stroke is discussed.
Department of Neurology, University of Tennessee, Memphis 38163.
K J
KJ
Gaines
C
C
Chesney
R
R
Vander Zwaag
C
C
Cape
D000368:Aged; D000990:Antithrombin III / Q000032:analysis; D044383:Black People; D001777:Blood Coagulation; D002561:Cerebrovascular Disorders / Q000097:blood*; D005260:Female; D005337:Fibrin / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D010978:Platelet Factor 4 / Q000032:analysis; D011486:Protein C / Q000032:analysis; D012016:Reference Values; D044465:White People
D011486:Protein C; D010978:Platelet Factor 4; D000990:Antithrombin III; D005337:Fibrin; D005340:Fibrinogen