Neisserial surface variation: how and why?
Neisseria gonorrhoeae exhibits striking variability in several of its surface components (pili, Opa proteins and lipooligosaccharide) in vivo and in vitro. Such flagrant variation of this mucosal pathogen's surface components contrasts sharply with changes in single surface components of blood-borne trypanosomes and borreliae. Despite these differences, similar molecular events are sometimes involved.
Rocky Mountain Laboratories, National Institutes of Health, Hamilton, Montana.
J
J
Swanson
R J
RJ
Belland
S A
SA
Hill
D000818:Animals; D000942:Antigens, Bacterial / Q000235:genetics / Q000378:metabolism; D001422:Bacterial Adhesion; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000378:metabolism; D001898:Borrelia / Q000378:metabolism; D036781:Fimbriae Proteins; D010861:Fimbriae, Bacterial; D005785:Gene Conversion; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D014644:Genetic Variation; D008070:Lipopolysaccharides / Q000378:metabolism; D009344:Neisseria gonorrhoeae / Q000235:genetics / Q000648:ultrastructure*; D011995:Recombination, Genetic; D013045:Species Specificity; D013499:Surface Properties; D014169:Transformation, Bacterial; D014346:Trypanosoma brucei brucei / Q000378:metabolism
D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D008070:Lipopolysaccharides; C050308:opacity proteins; D036781:Fimbriae Proteins