Mutagenicity of pyrrolizidine alkaloids in the Salmonella typhimurium/mammalian microsome system.
The mutagenicity of a series of pyrrolizidine alkaloids, and of extracts from several Italian Senecio species containing pyrrolizidine alkaloids, including S. inaequidens, S. fuchsii and S. cacaliaster, were tested using the Salmonella typhimurium/mammalian microsome system. Retrorsine, senecivernine, seneciphylline and the Senecio extracts showed a weakly mutagenic activity.
Dipartimento di Scienza e Technologia del Farmaco, Universitá delgi Studi di Torino, Turin, Italy.
P
P
Rubiolo
L
L
Pieters
M
M
Calomme
C
C
Bicchi
A
A
Vlietinck
D
D
Vanden Berghe
D000818:Animals; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D010936:Plant Extracts / Q000633:toxicity*; D010947:Plants, Toxic; D011763:Pyrrolizidine Alkaloids / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000187:drug effects; D012674:Senecio / Q000737:chemistry*
D009153:Mutagens; D010936:Plant Extracts; D011763:Pyrrolizidine Alkaloids