Induction of peroxisomal beta-oxidation genes by retinoic acid in cultured rat hepatocytes.
Retinoic acid is reported here to induce peroxisomal beta-oxidation activities in cultured rat hepatocytes, with a concomitant increase in respective peroxisomal mRNAs. The concentrations of retinoic acid required for inducing liver peroxisomal acyl-CoA oxidase were similar to those required for inducing liver transglutaminase. A putative 5'-flanking response element for retinoic acid may be found within the enhancer region involved in the induction of peroxisomal genes by xenobiotic amphipathic carboxylates.
Department of Biochemistry, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
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R
Hertz
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Bar-Tana
D000101:Acetyl-CoA C-Acetyltransferase / Q000235:genetics; D042962:Acyl-CoA Oxidase; D000818:Animals; D001483:Base Sequence; D002478:Cells, Cultured; D004790:Enzyme Induction; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008830:Microbodies / Q000187:drug effects / Q000378:metabolism*; D008969:Molecular Sequence Data; D009255:Nafenopin / Q000494:pharmacology; D010088:Oxidoreductases / Q000096:biosynthesis / Q000235:genetics*; D012333:RNA, Messenger / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011503:Transglutaminases / Q000096:biosynthesis / Q000235:genetics*; D014212:Tretinoin / Q000494:pharmacology*
D012333:RNA, Messenger; D009255:Nafenopin; D014212:Tretinoin; D010088:Oxidoreductases; D042962:Acyl-CoA Oxidase; D000101:Acetyl-CoA C-Acetyltransferase; D011503:Transglutaminases