Colonization factor antigen CFA/IV (PCF8775) of human enterotoxigenic Escherichia coli: nucleotide sequence of the CS5 determinant.
Human enterotoxigenic Escherichia coli isolates expressing the colonization factor antigen CFA/IV (previously designated PCF8775) produce plasmid-encoded CS5 fimbriae. The nucleotide sequence of the region encoding the major CS5 fimbrial subunit was determined. The subunit is synthesized as a precursor of 203 amino acids (20.85 kDa) with a mature protein of 181 amino acids corresponding to a size of 18.6 kDa. The CS5 subunit shows homology to the corresponding component of porcine enterotoxigenic E. coli F41, particularly within the signal sequence and at the carboxy terminus.
Department of Microbiology and Immunology, University of Adelaide, Australia.
C A
CA
Clark
M W
MW
Heuzenroeder
P A
PA
Manning
D000595:Amino Acid Sequence; D000942:Antigens, Bacterial / Q000235:genetics*; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics*; D001483:Base Sequence; D000939:Epitopes / Q000032:analysis; D004926:Escherichia coli / Q000235:genetics*; D036781:Fimbriae Proteins; D010861:Fimbriae, Bacterial; D004854:Herpesvirus 4, Human; D006801:Humans; D008969:Molecular Sequence Data
D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D000939:Epitopes; C022924:colonization factor antigens; D036781:Fimbriae Proteins