Chronic treatment with naftidrofuryl attenuates the development of vascular hypersensitivity to serotonin in the spontaneously hypertensive rat.
Three-month-old spontaneously hypertensive rats were treated for 1, 2, or 3 months with daily intraperitoneal injections of naftidrofuryl (30 mg/kg). Systolic arterial pressure was measured. Tail arteries were removed and perfused at a constant flow rate of 2 ml/min. A concentration-response curve for serotonin was prepared. A second curve was then constructed in the presence of naftidrofuryl. Chronic treatment with naftidrofuryl had no effect on blood pressure but produced a decrease in the maximal vasoconstrictor response and the sensitivity to serotonin in vitro. The in vitro sensitivity to naftidrofuryl was unchanged. These studies suggest that chronic treatment with a dose of naftidrofuryl that does not modify blood pressure attenuates the in vitro vascular sensitivity to serotonin.
Laboratoire de Pharmacologie, Faculté des Sciences Pharmaceutiques et Biologiques, Nancy, France.
E
E
Thorin
C
C
Capdeville
G
G
Trocklé
N
N
Wiernsperger
J
J
Atkinson
D000818:Animals; D001808:Blood Vessels / Q000187:drug effects*; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D008297:Male; D009257:Nafronyl / Q000627:therapeutic use*; D051381:Rats; D011918:Rats, Inbred SHR; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D013997:Time Factors; D014661:Vasoconstriction / Q000187:drug effects*
D012702:Serotonin Antagonists; D009257:Nafronyl