Regional localization of the intestinal mucin gene MUC3 to chromosome 7q22.
The gene MUC3 which codes for a mucin expressed in intestine (Gum et al. 1990) has previously been mapped, using somatic cell hybrids, to chromosome 7. We describe here the regional localization of MUC3 to chromosome 7q22 by in situ hybridization. Preliminary linkage analysis using CEPH (Centre d'Etude du Polymorphisme Humain) families supports this assignment and places MUC3 in the same linkage group as COL1A2 and CFTR.
MRC Human Biochemical Genetics Unit, Galton Laboratory, University College London, UK.
M F
MF
Fox
F
F
Lahbib
W
W
Pratt
J
J
Attwood
J
J
Gum
Y
Y
Kim
D M
DM
Swallow
D000595:Amino Acid Sequence; D002478:Cells, Cultured; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008214:Lymphocytes / Q000648:ultrastructure; D008969:Molecular Sequence Data; D009077:Mucins / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length
D005819:Genetic Markers; D009077:Mucins