Randomised controlled trial of effect of fish-oil supplementation on pregnancy duration.
The high birthweights and long duration of pregnancy in the Faroe Islands led us to suggest that a high intake of marine-fat-derived n-3 fatty acids might prolong pregnancy by shifting the balance of production of prostaglandins involved in parturition. We have compared the effects on pregnancy duration, birthweight, and birth length of a fish-oil supplement, a control olive-oil supplement, and no supplementation. 533 healthy Danish women in week 30 of pregnancy were randomly assigned in a ratio of 2/1/1 to fish oil (four 1 g Pikasol capsules [containing 2.7 g n-3 fatty acids] per day), olive oil (four 1 g capsules per day), or no supplement. The three groups differed in mean length of gestation (p = 0.006), which was highest in the fish-oil group and lowest in the olive-oil group; the result was similar when the analysis was restricted to women with an estimate of gestation length based on early ultrasound findings (443 women). Pregnancies in the fish-oil group were on average 4.0 (95% confidence interval 1.5-6.4) days longer than those in the olive-oil group; the difference in birthweight was 107 (1-214) g. The effect of supplementation on length of gestation was influenced by intake of fish and of fish oil: the difference between fish-oil and other groups was increased by a low fish intake at baseline. Fish-oil supplementation in the third trimester seems to prolong pregnancy without detrimental effects on the growth of the fetus or on the course of labour.
Institute of Epidemiology and Social Medicine, University of Aarhus, Denmark.
S F
SF
Olsen
J D
JD
Sørensen
N J
NJ
Secher
M
M
Hedegaard
T B
TB
Henriksen
H S
HS
Hansen
A
A
Grant
D000328:Adult; D001724:Birth Weight; D001827:Body Height; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007231:Infant, Newborn; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology; D011247:Pregnancy / Q000187:drug effects*; D011256:Pregnancy Outcome; D011263:Pregnancy Trimester, Third; D013997:Time Factors
D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D010938:Plant Oils