[The correlation between clozapine saliva level and clinical response as well as side effect in patient with schizophrenia].
It was measured for clozapine saliva level in 62 patients with schizophrenia taking clozapine, the study have found that therapeutic window was at the range from 550 ng/ml to 920 ng/ml in 34 patients with duration more than two years and was at the range from 400 ng/ml to 510 ng/ml in 28 patients with duration less than two years. Clozapine saliva concentration has positively correlated with improvement of though disorders and hostility & suspiciousness in 30 patients with duration more than two years and with improvement of activation in 12 patients with duration less than two years and with anti-adrenergic side effect in 62 patients, the latter effect was significant increased when clozapine saliva level was more than 380 ng/ml.
Nanjing Neuropsychiatric Hospital.
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Yu
D000293:Adolescent; D000328:Adult; D010054:Brief Psychiatric Rating Scale; D003024:Clozapine / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000378:metabolism*; D012559:Schizophrenia / Q000188:drug therapy* / Q000378:metabolism*
D003024:Clozapine