Effect of benzoyl peroxide on two-stage oral carcinogenesis and gamma-glutamyl transpeptidase in hamsters.
Hamster buccal pouches were treated with 7,12-dimethylbenz(a)anthracene (DMBA) triweekly for 3 wk and subsequently with 40% benzoyl peroxide (BP) in acetone for up to 27 wk. BP treatment resulted in a marked hyperplasiogenic effect and a weak tumor promoting effect. Whereas most carcinogens and tumor promoters induce gamma-glutamyl transpeptidase (GGT) activity, BP diminished its activity as compared to controls. Comparable results have also been noted in the liver, where a group of newly isolated hepatocarcinogens, peroxisome proliferators (PP), also characteristically deplete the GGT activity and placental glutathione S-transferase (GST-P), another tumor marker.
Faculty of Dentistry, University of British Columbia, Vancouver, Canada.
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D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001585:Benzoyl Peroxide / Q000494:pharmacology*; D014408:Biomarkers, Tumor / Q000032:analysis; D002278:Carcinoma in Situ / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology; D003043:Cocarcinogenesis; D006224:Cricetinae; D004357:Drug Synergism; D004848:Epithelium / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D006097:Granulation Tissue / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D008297:Male; D008647:Mesocricetus; D009061:Mouth Mucosa / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D009062:Mouth Neoplasms / Q000139:chemically induced* / Q000201:enzymology / Q000473:pathology*; D005723:gamma-Glutamyltransferase / Q000032:analysis*
D014408:Biomarkers, Tumor; D015127:9,10-Dimethyl-1,2-benzanthracene; D005723:gamma-Glutamyltransferase; D001585:Benzoyl Peroxide