HLA polymorphisms and evolution.
Polymorphisms within the human MHC are of interest to immunologists, for their functional significance, and to geneticists, as markers of populations. Here, Eleanor Riley and Olle Olerup describe how molecular analysis of the HLA complex is beginning to reveal the true extent of class II diversity, and demonstrate the use of this information to clarify the historical relationships between different human populations.
Institute of Cell, Animal and Population Biology, University of Edinburgh, UK.
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D000349:Africa; D000483:Alleles; D000818:Animals; D001208:Asia; D005075:Biological Evolution; D005580:Fossils; D005787:Gene Frequency; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes; D015186:Hominidae / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D008285:Major Histocompatibility Complex; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D044469:Racial Groups / Q000235:genetics; D012641:Selection, Genetic
D006680:HLA Antigens