Analgesic actions of dynorphin A(1-13) antiserum in the rat brain stem.
This study was performed to evaluate the effects of dynorphin A(1-3) antiserum when microinjected into an active hyperalgesic region within the rat brain stem. When administered within the dorsal posterior mesencephalic tegmentum (DPMT) of intact conscious rats, dynorphin A(1-13) antiserum produced rapid onset and persistent prolongation of a low intensity thermally evoked tail avoidance response (LITETAR). These analgesic actions of the dynorphin A(1-13) antiserum appeared to be dose dependent. These studies support previous hypotheses about the existence of tonically active brain stem opioid hyperalgesic process. Further, the results provide indirect evidence for a potential role of brain stem dynorphin(s) in facilitating pain.
Department of Anesthesiology, University of Kentucky, College of Medicine, Lexington 40536-0216.
S R
SR
Hamann
W R
WR
Martin
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000906:Antibodies / Q000008:administration & dosage / Q000502:physiology*; D001933:Brain Stem; D004305:Dose-Response Relationship, Drug; D004399:Dynorphins / Q000276:immunology*; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D008845:Microinjections; D010146:Pain / Q000517:prevention & control; D010446:Peptide Fragments / Q000276:immunology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013681:Tegmentum Mesencephali
D000700:Analgesics; D000906:Antibodies; D010446:Peptide Fragments; C026843:dynorphin (1-13); D004399:Dynorphins