Evidence for an altered kinetics of DNA excision-repair in cells infected by herpes simplex virus type 1.
In cells infected with herpesviruses a series of host cell nuclear changes can be observed in a temporal sequence. Such changes include chromosome aberrations. The precise mechanism by which virus infection produces chromosome damage is not known, but we have previously reported that herpes simplex virus type 1 (HSV-1) induces a significant number of single-stranded breaks in the host cell DNA at early hours of infection and in a time-dependent fashion. Here, it is reported that HSV-1-infected cells subjected to irradiation with ultraviolet light, show an altered kinetics in the normal process of DNA excision-repair at early hours of infection.
Aranda-Anzaldo
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Laboratory of Immunobiology, Faculty of Medicine, Paris, France.
D000818:Animals; D016590:Aphidicolin / Q000494:pharmacology; D002869:Chromosome Aberrations; D003561:Cytarabine / Q000494:pharmacology; D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects; D006367:HeLa Cells / Q000378:metabolism / Q000382:microbiology / Q000528:radiation effects; D006801:Humans; D007700:Kinetics; D007739:L Cells / Q000378:metabolism / Q000382:microbiology / Q000528:radiation effects; D051379:Mice; D018139:Simplexvirus / Q000502:physiology*; D014466:Ultraviolet Rays
D003561:Cytarabine; D016590:Aphidicolin