The human pseudoautosomal GM-CSF receptor alpha subunit gene is autosomal in mouse.
The gene encoding the granulocyte macrophage colony stimulating factor receptor alpha subunit (CSF2RA) has previously been mapped to the pseudoautosomal region of the human sex chromosomes. In contrast, we report that the murine locus, Csf2ra, maps to an autosome in the laboratory mouse. By in situ hybridization and genetic mapping, Csf2ra maps at telomeric band D2 of mouse chromosome 19. This first instance of a pseudoautosomal locus in human being autosomal in mouse, indicates incomplete conservation between the human and mouse X chromosomes and suggests that the genetic content of the pseudoautosomal region may differ between species of eutherian mammals due to chromosomal rearrangements.
Disteche
C M
CM
Department of Pathology, University of Washington, Seattle 98195.
Brannan
C I
CI
Larsen
A
A
Adler
D A
DA
Schorderet
D F
DF
Gearing
D
D
Copeland
N G
NG
Jenkins
N A
NA
Park
L S
LS
D000818:Animals; D002871:Chromosome Banding; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000235:genetics*; D006801:Humans; D017403:In Situ Hybridization; D046911:Macromolecular Substances; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009115:Muridae; D012150:Polymorphism, Restriction Fragment Length; D016615:Telomere; D014960:X Chromosome
D046911:Macromolecular Substances; D016178:Granulocyte-Macrophage Colony-Stimulating Factor