The effect of ethanol on responses of the isolated rabbit ileocolic artery.
Antagonist drugs were used to separate the purinergic and adrenergic contributions involved in the sympathetic vasopressor responses produced by electrical field stimulation in the ileocolic artery of the rabbit. Blocking drugs were applied either alone or in various combinations and sequences. The effect of ethanol was studied in conditions of alpha-adrenoceptor blockade, P2x purinoceptor desensitisation, or in the absence of antagonists. From these studies it is concluded that ethanol has a selective potentiating effect on alpha-adrenoceptor-mediated responses.
Autonomic Physiology Unit, University of Glasgow, U.K.
J M
JM
Bulloch
J C
JC
McGrath
D000255:Adenosine Triphosphate / Q000031:analogs & derivatives / Q000494:pharmacology; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D001158:Arteries / Q000187:drug effects*; D003106:Colon / Q000098:blood supply; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D007082:Ileum / Q000098:blood supply; D066298:In Vitro Techniques; D008297:Male; D011224:Prazosin / Q000494:pharmacology; D011817:Rabbits; D014661:Vasoconstriction / Q000187:drug effects
D000317:Adrenergic alpha-Antagonists; D000431:Ethanol; D000255:Adenosine Triphosphate; C002630:alpha,beta-methyleneadenosine 5'-triphosphate; D011224:Prazosin