Fluoxetine and trifluoperazine in human brain: a 19F-nuclear magnetic resonance spectroscopy study.
Fluorine-19 (19F) is a nonradioactive isotope that is well-suited to nuclear magnetic resonance spectroscopy (NMRS) and is a constituent of several medications used to treat psychiatric illnesses. Fluoxetine, a trifluorinated agent, generated a signal from brain that was readily measured by 19F-NMRS. Estimated brain concentrations ranged from 1.3-5.7 micrograms/ml in six subjects at a steady state dose of 40 mg/day. Enhanced sensitivity of 19F has been obtained by conforming the surface coil to the shape of the forehead. Hence, at the current state of development, 19F-NMRS can be applied to clinical questions relevant to concentrations of fluoxetine in brain. We also report observation of NMRS signals from fluorinated neuroleptics in a number of patients at steady state. These signals continue to be difficult to obtain, although a correlation between dose and estimated brain concentrations is suggested.
University of Arkansas for Medical Sciences, Little Rock.
C N
CN
Karson
J E
JE
Newton
P
P
Mohanakrishnan
J
J
Sprigg
R A
RA
Komoroski
D000328:Adult; D014150:Antipsychotic Agents / Q000145:classification / Q000378:metabolism* / Q000627:therapeutic use; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism*; D003866:Depressive Disorder / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy; D011859:Radiography; D012559:Schizophrenia / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy; D013313:Stress Disorders, Post-Traumatic / Q000188:drug therapy
D014150:Antipsychotic Agents