[HIV-1 proviral DNA sequences in the saliva of patients with HIV infection].
In order to understand the significance of presence of HIV-1 in saliva, we searched for by PCR HIV-1 proviral sequences in the saliva cells of 49 HIV-1 infected patients. Seven out 49 specimens resulted positive, 4 of which were from patients with PGL, 1 with ARC and 2 with AIDS. Four patients had a CD4+ lymphocyte counts < 200/cmm and in 3 patients the CD4+ lymphocyte count ranged from 200 to 400/cmm. Two patients were treated with AZT, 1 with DDI and 4 had no antiretroviral treatment. In conclusion, although HIV-1 proviral sequences have been found in saliva of HIV-1 infected patients, a larger group of patients should be investigated to define more precisely the role of HIV-1 in saliva.
Istituto di Malattie Infettive, II Facoltà di Medicina, Università di Napoli.
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Ceccherini Nelli
D001483:Base Sequence; D015496:CD4-Positive T-Lymphocytes; D004279:DNA, Viral / Q000032:analysis*; D016049:Didanosine / Q000627:therapeutic use; D015752:Genes, env; D015658:HIV Infections / Q000188:drug therapy / Q000382:microbiology*; D015497:HIV-1 / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007958:Leukocyte Count; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011533:Proviruses / Q000302:isolation & purification*; D012463:Saliva / Q000382:microbiology*; D015215:Zidovudine / Q000627:therapeutic use
D004279:DNA, Viral; D015215:Zidovudine; D016049:Didanosine
Sequenze provirali di HIV-1 nella saliva di soggetti con infezione da HIV.