The Zollinger-Ellison syndrome. A collective surgical experience.
A retrospective study of 90 surgically treated patients with the Zollinger-Ellison syndrome seen from 1958 through 1990 was performed. Fifteen patients had Zollinger-Ellison syndrome as a manifestation of multiple endocrine neoplasia type I. Preoperative tumor localization was positive in 46% of 54 patients studied. Gastrinomas were identified in 66% of patients, 38% of the tumors being malignant. Postoperative eugastrinemia was achieved in 11% of patients after a variety of surgical procedures. Exploratory laparotomy provides the only chance for cure and identifies the significant prognostic factors associated with long-term patient survival: small tumor size, extrapancreatic primary, and absence of tumor metastases.
Department of Surgery, Mayo Clinic, Rochester, MN 55905.
D R
DR
Farley
J A
JA
van Heerden
C S
CS
Grant
L J
LJ
Miller
D M
DM
Ilstrup
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008722:Methods; D008875:Middle Aged; D009377:Multiple Endocrine Neoplasia / Q000175:diagnosis / Q000601:surgery; D012189:Retrospective Studies; D015996:Survival Rate; D015043:Zollinger-Ellison Syndrome / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*