Pig ear skin as an in-vitro model for human skin permeability.
Pig skin has been shown to have similar histological and physiological properties to human skin and has been suggested as a good model for human skin permeability. In this series of experiments, the in-vitro permeability of pig ear skin was compared with human (abdominal) skin and rat (dorsal) skin using both hydrophilic (water, mannitol, paraquat) and lipophilic (aldrin, carbaryl, fluazifop-butyl) penetrants. Pig skin was found to have a closer permeability character than rat skin to human skin, particularly for lipophilic penetrants. Electrical conductivity measurements across pig skin membranes showed that skin conductivity could be a useful method for assessing the integrity of membranes, particularly when used in conjunction with water permeability assessments.
Dick
I P
IP
Imperial Chemical Industries plc, Central Toxicology Laboratory, Macclesfield, Cheshire, UK.
Scott
R C
RC
D000818:Animals; D004431:Ear, External; D004553:Electric Conductivity; D006801:Humans; D066298:In Vitro Techniques; D010539:Permeability; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption; D013045:Species Specificity; D013552:Swine