Strategies for improving plasmid stability in genetically modified bacteria in bioreactors.
Exploitation of recombinant organisms for the large-scale, commercial production of foreign proteins is often hampered by the problem of plasmid instability. A wide range of strategies have been reported for improving the stability of recombinant organisms. A combination of manipulating both the genetic design of recombinants and the conditions of culturing the organisms may be used to achieve stable host-vector associations during culture of recombinant organisms in bioreactors.
Kumar
P K
PK
Institut für Technische Chemie, Universität Hannover, FRG.
Maschke
H E
HE
Friehs
K
K
Schügerl
K
K
D001419:Bacteria / Q000235:genetics*; D005818:Genetic Engineering; D005822:Genetic Vectors; D010957:Plasmids