Non-Hodgkin malignant lymphoma in the nails in the course of a chronic lymphocytic leukaemia.
We describe a 70-year-old woman with B-cell chronic lymphocytic leukaemia without nodal involvement, who developed non-Hodgkin malignant lymphoma in the toe-nails. Clinically, the affected nails looked like a typical mycotic infection, but later small tumours developed which affected the nails, and biopsy established the diagnosis. Treatment with chlorambucil (Leukeran) and prednisolone had a striking effect. Malignant infiltration of B lymphocytes in the nails is very rare, but should be considered in patients with malignant haematologic disease.
Department of Medicine, Hvidovre University Hospital, Copenhagen, Denmark.
L M
LM
Pedersen
H
H
Nordin
H
H
Nielsen
I
I
Lisse
D000368:Aged; D001706:Biopsy; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*; D009260:Nail Diseases / Q000473:pathology*