Influence of the host related factors in the development of the hepatosplenic form of schistosomiasis mansoni.
The frequency of hepatosplenomegaly in endemic areas is not proportional to the fecal ova count. This may be explained by epidemiological genetic. The occurrence of two or more cases of schistosomal hepatosplenomegaly in nuclear family is much higher than expected. The concentration is higher among siblings than it is among mothers and children of father and children. It is not significant between father and mother. If the mother, instead of the father, has hepatosplenic schistosomiasis the relative risk for the child to acquire hepatosplenomegaly is at least five times (the maternal affect). The inbreeding is higher in the hepatosplenic than in the hepato-intestinal patients. In some areas in Brazil the hepatosplenic form of the schistosomiasis mansoni occurs with much higher frequency in whites than in blacks. After treatment, reversion of hepatosplenic schistosomiasis occurs more frequently in non-whites. It seems that the resistance of blacks to the hepatosplenic form of schistosomiasis may be related to the glyoxalase system, perhaps associated to another genetic marker. The hepatosplenic schistosomiasis is less frequent in longilineal individuals. In some areas the hepatosplenic form of schistosomiasis is more frequent in A blood group of ABO system. The family heredograms do not suggest a single mendelian inheritance, but probably a multifactorial and possibly polygenic one.
Disciplina de Doenças Infecciosas e Parasitárias, Faculdade de Medicina do Triângulo Mineiro, Uberaba, MG, Brasil.
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D000017:ABO Blood-Group System / Q000235:genetics; D000328:Adult; D044383:Black People / Q000235:genetics; D001938:Brazil / Q000453:epidemiology; D002648:Child; D004198:Disease Susceptibility / Q000208:ethnology; D020022:Genetic Predisposition to Disease; D006801:Humans; D008103:Liver Cirrhosis / Q000469:parasitology / Q000473:pathology; D009035:Mothers; D010270:Parasite Egg Count; D012555:Schistosomiasis mansoni / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D013154:Spleen / Q000469:parasitology
D000017:ABO Blood-Group System