Glomerulonephritis with end-stage liver disease in childhood.
Renal biopsies were done perioperatively in 18 children receiving liver grafts. All specimens showed glomerulonephritis, which was mesangial-proliferative in 15 and mesangio-capillary in 3. Of the 16 children who were alive four or more months after transplantation, only 1 showed progressive deterioration of renal function; 1 other had a subnormal but static glomerular filtration rate. In all 6 children who had proteinuria before operation, the urine became normal.
Department of Paediatrics, Addenbrooke's Hospital, Cambridge, UK.
G
G
Noble-Jamieson
S
S
Thiru
P
P
Johnston
P
P
Friend
N D
ND
Barnes
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications*; D006801:Humans; D007223:Infant; D008107:Liver Diseases / Q000150:complications* / Q000601:surgery; D016031:Liver Transplantation; D011183:Postoperative Complications