Physicochemical properties of oxamniquine indicate a new polymorphic form.
New dissolution rate, chemical stability and thermal analysis data are reported for an anti-schistosomal drug, oxamniquine. A slow dissolution rate (40-70% in 1 h) was found, which may contribute to its erratic clinical response. The drug was found to be chemically stable in water for at least 21 days at 37 degrees C. Dissolution rate and thermal analysis evidence is presented for a previously unreported polymorph (Form III). This form appears to be intermediate in physical stability between the known Forms I and II.
Prankerd
R J
RJ
Department of Pharmaceutics, College of Pharmacy, University of Florida, J. Hillis Miller Health Center, Gainesville 32610.
Ahmed
S M
SM
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003460:Crystallization; D010073:Oxamniquine / Q000737:chemistry*; D011108:Polymers; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet
D011108:Polymers; D010073:Oxamniquine