[The complement activation system in acute poststreptococcal glomerulonephritis].
The activation of the complement system is very important part of the immunologic process. Measuring levels of products of complement activation is a useful diagnostic and prognostic procedure. This report presents the results of a follow-up of 54 children with acute poststreptococcal glomerulonephritis. At the beginning of the disease, all patients (i. e. 100%) had decreased levels of C3 component of the complement system, and 72.2% patients had decreased levels of the haemolytic complement. The mean value of the control measurements increased significantly from one measurement to another (with p < 0.01, and within 6 weeks after the beginning of the disease, it reached the normal range. According to our results, the activation of the complement system was induced by the classical pathway. We cannot explain why the component C4 did not take part in it. According to the results of the haemolytic assay, the alternative pathway of activation was used too. We found that there was a correlation between improvement of clinical features and decrease of metabolisation of complement components.
Cemerlić-Zecević
E
E
Macanović
M
M
D000208:Acute Disease; D002648:Child; D003167:Complement Activation; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D015941:Complement Hemolytic Activity Assay; D005921:Glomerulonephritis / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D011446:Prospective Studies; D013290:Streptococcal Infections / Q000150:complications*
D003176:Complement C3; D003181:Complement C4
Aktivacija sistema komplementa u akutnom poststreptokoknom glomerulonefritisu (APSGN).