Behavioral effects of neural transplantation.
Considerable evidence suggests that transplantation of fetal neural tissue ameliorates the behavioral deficits observed in a variety of animal models of CNS disorders. However, it is also becoming increasingly clear that neural transplants do not necessarily produce behavioral recovery, and in some cases have either no beneficial effects, magnify existing behavioral abnormalities, or even produce a unique constellation of deficits. Regardless, studies demonstrating the successful use of neural transplants in reducing or eliminating behavioral deficits in these animal models has led directly to their clinical application in human neurodegenerative disorders such as Parkinson's disease. This review examines the beneficial and deleterious behavioral consequences of neural transplants in different animal models of human diseases, and discusses the possible mechanisms by which neural transplants might produce behavior recovery.
Emerich
D F
DF
Cyto Therapeutics, Inc., Providence, RI 02906.
Ragozzino
M
M
Lehman
M N
MN
Sanberg
P R
PR
D000818:Animals; D001519:Behavior; D001522:Behavior, Animal; D001921:Brain / Q000502:physiology / Q000503:physiopathology; D016380:Brain Tissue Transplantation / Q000502:physiology*; D002493:Central Nervous System Diseases / Q000503:physiopathology / Q000523:psychology / Q000601:surgery*; D004195:Disease Models, Animal; D005260:Female; D016332:Fetal Tissue Transplantation / Q000502:physiology*; D006085:Graft Survival; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000503:physiopathology / Q000523:psychology / Q000601:surgery