Aminocarnitine and related compounds as inhibitors of carnitine transferases: physiologic implications.
beta-Aminocarnitine and its N-acetyl and N-palmitoyl amides were examined as inhibitors of carnitine acetyltransferase, carnitine palmitoyltransferase, and of fatty-acid oxidation in whole animals, tissues, and hepatic microsomal systems. Results were consistent with subsequent findings that aminocarnitine and palmitoylcarnitine have significant antiketogenic and hypoglycemic effects in experimental animals.
D000818:Animals; D001622:Betaine / Q000031:analogs & derivatives* / Q000494:pharmacology; D002331:Carnitine; D002332:Carnitine O-Acetyltransferase / Q000037:antagonists & inhibitors*; D002334:Carnitine O-Palmitoyltransferase / Q000037:antagonists & inhibitors*; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology
D001622:Betaine; C045761:emeriamine; D002334:Carnitine O-Palmitoyltransferase; D002332:Carnitine O-Acetyltransferase; D002331:Carnitine