Vecuronium: an anthropometric comparison.
This study set out to determine if there was any resistance to vecuronium in Nepalese studied in Nepal compared with Nepalese, Chinese and European patients studied in Hong Kong. The four groups, each of 10 male and 10 female patients, were intubated 60 s after administration of 0.1 mg.kg-1 vecuronium. The Nepalese patients in Nepal had significantly less satisfactory intubating conditions (p = 0.002). Similarly, male patients had significantly less satisfactory conditions than female patients (p = 0.004). Some anthropometric measurements were significantly different between the patients in Nepal and those in Hong Kong. There were also sex-related anthropometric differences. It is suggested that differences in response to vecuronium could be explained by differences in distribution volume and muscle mass.
Houghton
I T
IT
British Military Hospital, Hong Kong.
Aun
C S
CS
Oh
T E
TE
D000328:Adult; D000886:Anthropometry; D002681:China / Q000208:ethnology; D004351:Drug Resistance; D005260:Female; D006723:Hong Kong; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D009390:Nepal / Q000208:ethnology; D044469:Racial Groups / Q000235:genetics; D012727:Sex Characteristics; D006113:United Kingdom / Q000208:ethnology; D014673:Vecuronium Bromide / Q000494:pharmacology*
D014673:Vecuronium Bromide