[Reproductive and developmental toxicity studies of 6-amidino-2-naphthyl 4(-)[(4,5-dihydro-1H-imidazol-2-yl) amino] benzoate dimethanesulfonate (FUT-187). (IV)--Oral administration to New Zealand white rabbits during the period of fetal organogenesis.
Oral administration of 6-amidino-2-naphthyl 4(-)[(4,5-dihydro-1H-imidazol-2-yl)amino] benzoate dimethanesulfonate (FUT-187) at doses of 10, 30 and 100 mg/kg was given to New Zealand White rabbits on days 6 to 18 of gestation. The following results were obtained. Decreased food consumption and suppression of body weight gain in dams were observed and these changes contributed to the increase in aborted or prematured births and increased fetal mortality at the 100 mg/kg group. There were changes attributable to FUT-187 on external, skeletal and visceral examinations of fetuses. Based on the above, the no-effect dose level in dams and fetuses in the present study is 30 mg/kg/day.
Research Laboratories, Torii & Co., Ltd., Chiba, Japan.
K
K
Shimamura
M
M
Terabayashi
S
S
Kuramoto
N
N
Hasegawa
K
K
Terazawa
A
A
Maruden
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D007093:Imidazoles / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011817:Rabbits; D012098:Reproduction / Q000187:drug effects*
D007093:Imidazoles; C058875:sepimostate mesilate