The effects of various peptides on human isolated gut muscle.
The effects of eleven peptides of gastrointestinal origin have been studied on the contraction, relaxation and spontaneous activity of circular and longitudinal muscle strips from different regions of the human gastrointestinal tract. The effects varied with the peptides and sometimes with the region and muscle layer. There was either contraction, no effect, or relaxation and/or inhibition of an acetylcholine-induced contraction. Responses to some peptides are consistent with the possibility that they may contribute directly to the control of motility: galanin, neurotensin and substance P might be involved in contraction, and vasoactive intestinal peptide, peptide histidine isoleucine and peptide histidine methionine might be inhibitory transmitters.
Department of Surgery, Rayne Institute, King's College School of Medicine and Dentistry, London, UK.
A
A
Bennett
I F
IF
Stamford
G J
GJ
Sanger
S R
SR
Bloom
D000109:Acetylcholine / Q000494:pharmacology; D003106:Colon / Q000187:drug effects*; D004347:Drug Interactions; D006801:Humans; D007422:Intestines / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D010455:Peptides / Q000494:pharmacology / Q000502:physiology*; D013270:Stomach / Q000187:drug effects*; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology
D010455:Peptides; D014660:Vasoactive Intestinal Peptide; D000109:Acetylcholine