Tyrosine aminotransferase: a transaminase among others?
Tyrosine aminotransferase (L-tyrosine: 2 oxoglutarate aminotransferase; EC 2.6.1.5; TATase) is the first enzyme in the catabolic pathway of tyrosine. The gene of this transaminase is regulated by glucocorticoid hormones as well as via the cAMP pathway. This review gives a brief survey of the structural and physico-chemical properties of this well-known protein. A comparative study of the properties of TATase with other aminotransferases is also included to analyse this molecule for itself, and not only as a marker used in studies on enzymatic induction. Finally, the regulation of the gene expression is presented, in order to underline a few important features of this model.
Institut de Biologie Moléculaire et Cellulaire du CNRS, Laboratoire de Biochimie, Strasbourg, France.
J B
JB
Dietrich
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004247:DNA; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D008969:Molecular Sequence Data; D000637:Transaminases / Q000737:chemistry / Q000378:metabolism; D014444:Tyrosine Transaminase / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism
D004247:DNA; D000637:Transaminases; D014444:Tyrosine Transaminase