A relationship between circulating natural glucocorticoids and the mechanical responses of the heart in atricial and precocial rodents.
1. A comparison was made of the mechanical performance of heart muscle from mouse, an atricial mammal, with corticosterone as glucocorticoid and spiny mouse (Acomys cahirinus), a precocial mammal, with cortisol as glucocorticoid. 2. Force-frequency responses were negative in mouse and positive in spiny mouse. 3. During recovery, there was a gradual increase and an overshoot in the mouse, while in the spiny mouse there was an initial enhanced response, diminishing gradually with time. 4. High calcium concentration inhibited contractile tension in mouse heart, while it was positively inotropic in spiny mouse heart. Changes in the concentration of calcium did not change the patterns of force-frequency response. 5. Lowering the experimental temperature increased the time course and amplitude of the tension curve. However, various parameters exhibited different temperature sensitivity. 6. There was a significant difference in the levels of circulating cortisol between male and female spiny mice. 7. It is proposed that the differences in the mechanical responses of mouse and spiny mouse hearts may be explained in terms of the effects of the specific glucocorticoid hormone on the development of the sodium-calcium exchanger.
Department of Physiology, Mount Sinai School of Medicine, City University of New York, NY 10029.
Z J
ZJ
Penefsky
E
E
Diamond
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D003345:Corticosterone / Q000097:blood; D005260:Female; D005938:Glucocorticoids / Q000097:blood*; D006321:Heart / Q000254:growth & development; D006854:Hydrocortisone / Q000097:blood; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009115:Muridae / Q000502:physiology*; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology*; D013045:Species Specificity; D013696:Temperature
D005938:Glucocorticoids; D002118:Calcium; D003345:Corticosterone; D006854:Hydrocortisone