Alterations in rat alveolar surfactant system induced by treatment with carbicron (O-[(2-butenoic acid)-N,N-dimethylamide-3-yl]-O,O-dimethylphosphate).
1. Intoxication of rats with carbicron (O-([2-butenoic acid)-N,N-dimethylamide-3-yl]-O,O-dimethylphosphate) induced a reduction of the total phospholipids and phosphatidylcholine in lung alveolar surfactant. 2. The lipid transfer protein activity was inhibited due to carbicron treatment. 3. No alterations were observed in phospholipase A2 activity in the alveolar surfactant of intoxicated animals. The structural order parameter (SDPH) of bilayer liposomes, prepared from surfactant phospholipids of carbicron-treated rats also remained unchanged.
Department of Pathophysiology, Medical Academy, Sofia, Bulgaria.
E
E
Yanev
T
T
Markovska
A
A
Momchilova
R
R
Pankov
T
T
Sedloev
K
K
Koumanov
D000818:Animals; D002352:Carrier Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D005454:Fluorescence Polarization; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D009943:Organophosphorus Compounds / Q000633:toxicity*; D010741:Phospholipases A / Q000187:drug effects / Q000378:metabolism; D054467:Phospholipases A2; D010743:Phospholipids / Q000378:metabolism; D011650:Pulmonary Alveoli / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D011663:Pulmonary Surfactants / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D002352:Carrier Proteins; D007306:Insecticides; D009943:Organophosphorus Compounds; D010743:Phospholipids; D011663:Pulmonary Surfactants; C030363:lipid transfer protein; C000944:dicrotophos; D010741:Phospholipases A; D054467:Phospholipases A2