Sigma ligand-induced emesis in the pigeon.
Pigeons were fed a fixed amount of grain-based feed and behavior was observed after administration of doses of ditolyguanidine (DTG), (+)-3-(3-hydroxyphenyl)-N-(1-propyl)-piperidine [(+)-3-PPP], dextromethorphan, haloperidol, (+)-N-allylnormetazocine (NANM), alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine-butanol (BMY-14802) apomorphine, pentobarbital, propranolol, and MK-801. Of the drugs tested, DTG, dextromethorphan, and (+)-3-PPP each produced dose-related increases in the percentage of pigeons exhibiting an emetic response. The emetic response produced by DTG was antagonized by haloperidol and BMY-14802 but not by propranolol. These observations suggest that the emetic response in the pigeon may be mediated by sigma sites and is unlikely to be mediated by phencyclidine receptors.
Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock 72205.
T J
TJ
Hudzik
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D010856:Columbidae; D003915:Dextromethorphan / Q000494:pharmacology; D016291:Dizocilpine Maleate / Q000494:pharmacology; D015259:Dopamine Agents / Q000494:pharmacology; D006146:Guanidines / Q000037:antagonists & inhibitors; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D010620:Phenazocine / Q000031:analogs & derivatives / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D011957:Receptors, Opioid / Q000187:drug effects*; D017480:Receptors, sigma; D014839:Vomiting / Q000139:chemically induced*
D015259:Dopamine Agents; D006146:Guanidines; D010880:Piperidines; D011619:Psychotropic Drugs; D011743:Pyrimidines; D011957:Receptors, Opioid; D017480:Receptors, sigma; C050408:alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol; D016291:Dizocilpine Maleate; D003915:Dextromethorphan; C012134:SK&F 10047; C026539:preclamol; D011433:Propranolol; D010424:Pentobarbital; D010620:Phenazocine; D006220:Haloperidol; C050232:1,3-ditolylguanidine; D001058:Apomorphine