Effects of danazol on coagulant activity in the rat.
Coagulation factor activity was evaluated in female rats treated with danazol. Following 30 days of treatment, slight decreases in factor VII and X activities were noted. After 60 days, a prolongation of the prothrombin time, as well as a decrease in factor VII, was noted. The data suggest that in the rodent, danazol has minimal effects on coagulation activity.
Department of Obstetrics and Gynecology, Texas Tech Health Sciences Center, Lubbock.
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D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001779:Blood Coagulation Factors / Q000187:drug effects; D003613:Danazol / Q000494:pharmacology*; D005260:Female; D005340:Fibrinogen / Q000187:drug effects; D006487:Hemostasis / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D001779:Blood Coagulation Factors; D005340:Fibrinogen; D003613:Danazol