The prospects for therapy with tumour necrosis factors and their antagonists.
Tumour necrosis factors (TNFs) alpha and beta are capable of causing dramatic necrosis of solid tumours. TNF-alpha has undergone clinical trials as an anti-cancer drug. Finding a role for TNFs in the treatment of cancer will depend on suppressing severe side effects and targeting the drug. Conversely, due to the participation of TNFs in inflammatory responses, antagonists of TNF-alpha are being considered for the treatment of several conditions, especially septic shock.
Institute of Molecular and Cell Biology, National University of Singapore.
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Porter
D000818:Animals; D006801:Humans; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000627:therapeutic use*
D014409:Tumor Necrosis Factor-alpha