Termination of second messenger signaling in olfaction.
By using isolated rat olfactory cilia and a fast kinetics methodology, it has been demonstrated that odorant-induced second messenger signaling in the millisecond time range is terminated via phosphorylation reactions catalyzed by specific protein kinases. The cyclic adenosine nucleotide pathway is turned off by kinase A activity, whereas the inositol trisphosphate cascade is terminated by kinase C. The data support the concept that desensitization of odorant responses involves phosphorylation of key elements in the transduction cascade.
University Stuttgart-Hohenheim, Institute of Zoophysiology, Stuttgart, Federal Republic of Germany.
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Boekhoff
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Breer
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000818:Animals; D000242:Cyclic AMP / Q000502:physiology; D004988:Ethers, Cyclic / Q000494:pharmacology; D005246:Feedback; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D009570:Nitriles; D019319:Okadaic Acid; D009831:Olfactory Mucosa / Q000502:physiology*; D015240:Phorbol 12,13-Dibutyrate / Q000494:pharmacology; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D011494:Protein Kinases / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D015290:Second Messenger Systems / Q000502:physiology*; D015398:Signal Transduction; D012903:Smell / Q000502:physiology*; D013110:Sphingosine / Q000494:pharmacology; D013997:Time Factors
D004988:Ethers, Cyclic; D009570:Nitriles; D019319:Okadaic Acid; D015240:Phorbol 12,13-Dibutyrate; C054764:citralva; D015544:Inositol 1,4,5-Trisphosphate; D000242:Cyclic AMP; D011494:Protein Kinases; D011493:Protein Kinase C; D013110:Sphingosine; D015056:1-Methyl-3-isobutylxanthine