Effect of psychotropic drugs on histamine H2-receptors in rat isolated uterus.
The effects of the monoamine oxidase inhibitors iproniazid, nialamide and phenelzine, the neuroleptics haloperidol and thioridazine, and the benzodiazepines diazepam and clonazepam on histamine H2-receptors were assessed on rat isolated uterus. The monoamine oxidase inhibitors showed a slight non-competitive antihistamine H2 activity, while diazepam and clonazepam were devoid of any action. Haloperidol and thioridazine inhibited in a dose-dependent manner the tonic component of KCl induced contraction, while thioridazine under the same conditions exhibited a slight antihistamine H2 activity. These data show that the drugs tested are devoid of or elicited only a slight antihistamine H2 activity at high non-therapeutic concentrations.
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Valladolid, Spain.
F J
FJ
Alvarez
A
A
Galindo
A
A
Velasco
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000494:pharmacology; D001569:Benzodiazepines; D005260:Female; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D066298:In Vitro Techniques; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011970:Receptors, Histamine H2 / Q000187:drug effects*; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000187:drug effects*
D014151:Anti-Anxiety Agents; D014150:Antipsychotic Agents; D006635:Histamine H2 Antagonists; D008996:Monoamine Oxidase Inhibitors; D011619:Psychotropic Drugs; D011970:Receptors, Histamine H2; D001569:Benzodiazepines; D011189:Potassium Chloride