[Behavior of thyrotropic, triiodothyronine, thyroxine and cortisol hormone levels in blood serum of patients with duodenal ulcer treated with ranitidine].
Blood serum concentrations of thyrotropic hormone (TSH), triiodothyronine (T3), thyroxine (T4) and cortisol have been measured in 50 patients with duodenal ulcer. The determinations were repeated after a specific time of treatment with ranitidine: in 45 patients after 3 weeks and in 37 after additional 30 days of treatment. During the first period of treatment ranitidine was administered at a dose of 300 mg divided into two daily doses and during the second period of treatment at a single daily dose of 150 mg. A small but statistically significant changes, an increase in T3 and a decrease in TSH concentration, were observed before the treatment. No changes concerning these two parameters were found as an effect of the treatment. A decrease in the concentration of T4 was found, on the other hand, after three weeks of ranitidine administration. This decrease persisted after further 30 days of chronic treatment with ranitidine. No significant changes concerning blood serum cortisol concentration were found in any of the studied groups.
Klinika Chorób Wewnetrznych Instytutu Medycyny Klinicznej w Kielcach AM w Krakowie.
J
J
Przybyłowski
D
D
Kowalski
H
H
Widłak
K
K
Kowalska
M
M
Garmulewicz
D000328:Adult; D004381:Duodenal Ulcer / Q000097:blood* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D011899:Ranitidine / Q000627:therapeutic use*; D013963:Thyroid Hormones / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D013963:Thyroid Hormones; D014284:Triiodothyronine; D011899:Ranitidine; D013974:Thyroxine; D006854:Hydrocortisone
Zachowanie sie stezeń hormonu tyreotropowego, trójjodotyroniny, tyroksyny oraz kortyzolu w surowicy krwi chorych na wrzód dwunastnicy leczonych ranitydyna.