Pericholangitis with ulcerative colitis following autoimmune hepatitis over 12 years.
A 35-year-old woman was diagnosed as autoimmune hepatitis 12 years ago by abnormal findings of liver tests including lupus erythematosus (LE) cell phenomenon and liver biopsy. She was admitted in May 1990 with a history of lower gastrointestinal bleeding. Colonoscopy with biopsy and barium enema revealed chronic ulcerative colitis along the entire colon. Since liver tests did not respond well to prednisolone treatment, liver biopsy was again performed and it revealed periductal inflammation with small duct proliferation, a finding compatible with pericholangitis. We herein report this patient who was initially diagnosed as autoimmune hepatitis and thereafter found to be pericholangitis associated with ulcerative colitis.
Chujo
S
S
Second Department of Internal Medicine, Kobe University School of Medicine, Japan.
Sakamoto
C
C
Ohno
S
S
Morimoto
S
S
Miyamoto
M
M
Okano
H
H
Morita
S
S
Saeki
S
S
Oimomi
M
M
Fujimori
T
T
D000328:Adult; D000410:Alanine Transaminase / Q000032:analysis; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000032:analysis; D001327:Autoimmune Diseases / Q000150:complications* / Q000188:drug therapy; D001649:Bile Duct Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D003093:Colitis, Ulcerative / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D005260:Female; D006505:Hepatitis / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008099:Liver / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D005723:gamma-Glutamyltransferase / Q000097:blood
D011239:Prednisolone; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase