A new polymorphic site in the G6PD gene.
A polymorphic restriction site has been found in intron 11 of the gene for glucose-6-phosphate dehydrogenase (G6PD). This site is produced by a T----C substitution 13 bp upstream of exon 12, producing an NlaIII restriction site. In various populations there was a strong association between a T at nt 1311 of the G6PD cDNA and the presence of the NlaIII restriction site. Among African Americans, however, the presence of a C at nt 1311 was sometimes associated with the presence of a polymorphic NlaIII site.
Beutler
E
E
Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037.
Westwood
B
B
Sipe
B
B
D001483:Base Sequence; D044383:Black People / Q000235:genetics; D004252:DNA Mutational Analysis; D015252:Deoxyribonucleases, Type II Site-Specific / Q000235:genetics*; D005006:Ethnicity; D005796:Genes / Q000235:genetics*; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D012150:Polymorphism, Restriction Fragment Length; D015183:Restriction Mapping; D014481:United States; D001741:Black or African American
D005954:Glucosephosphate Dehydrogenase; C048422:endodeoxyribonuclease NlaIII; D015252:Deoxyribonucleases, Type II Site-Specific