Decreased visual evoked cortical response latency associated with cerebral ischaemia in the gerbil.
The observation of Xu et al. concerning reduction in latency of the visual evoked responses (VER) following cortical cryogenic injury, prompted us to ascertain whether similar VER changes could be demonstrable after ischaemic brain injury, especially, since both conditions have in common involvement of neuroexcitatory mechanisms. In our study, the Mongolian gerbils, which were subjected to 10 min bilateral carotid occlusion ischaemia, revealed decreased latency of the VER, with the peak of latency reduction between 4 and 7 h. An almost immediate decrease in VER latency was observed when glutamate was directly applied to the pial surface of the brain. These observations indicate that the reduction of VER latency may be related to neuroexcitation induced by release of excitatory amino acids, the latter constituting a widespread phenomenon, concomitant with brain injuries of various aetiologies.
Department of Neurology, Howard University College of Medicine, Washington, D.C. 20060.
R
R
Cohn
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S
Xu
H G
HG
Wagner
F
F
Joo
I
I
Klatzo
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D004569:Electroencephalography; D005074:Evoked Potentials, Visual / Q000187:drug effects; D005849:Gerbillinae; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D002546:Ischemic Attack, Transient / Q000503:physiopathology*; D013331:Strychnine / Q000494:pharmacology; D013997:Time Factors
D005971:Glutamates; D018698:Glutamic Acid; D013331:Strychnine