Effects of antipsychotic drugs on memory functions of schizophrenic patients.
In this research we investigated the effects of 4 antipsychotic drugs with different anticholinergic components on different memory functions of schizophrenic patients. Drugs were administered in cumulative doses and memory was tested 90 min after each drug was administered. The results show that chlorpromazine and thioridazine impaired short-term verbal memory after 6 h of sequential administration. Trifluoperazine and haloperidol improved short-term verbal memory from the third to the fifth administration. Immediate memory, long-term memory and visual short-term memory were not impaired by any drug.
Shalvatah Mental Health Center, Hod-Hasharon, Israel.
N
N
Eitan
Y
Y
Levin
E
E
Ben-Artzi
A
A
Levy
M
M
Neumann
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002746:Chlorpromazine / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006220:Haloperidol / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000187:drug effects*; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012153:Retention, Psychology / Q000187:drug effects; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D013881:Thioridazine / Q000009:adverse effects / Q000627:therapeutic use; D014268:Trifluoperazine / Q000009:adverse effects / Q000627:therapeutic use; D014706:Verbal Learning / Q000187:drug effects
D014150:Antipsychotic Agents; D014268:Trifluoperazine; D006220:Haloperidol; D013881:Thioridazine; D002746:Chlorpromazine