Chromatographic resolution of the chiral isomers of several beta-blockers over cellulose tris(3,5-dimethylphenylcarbamate) chiral stationary phase.
The optical resolution of seven beta-blockers which have in common the N-isopropyl-3-aryloxy-2-hydroxypropylamine moiety was carried out by HPLC using the cellulose tris(3,5-dimethylphenylcarbamate) chiral stationary phase to quantitatively characterize the enantioselectivity of these compounds. The capacity factors and separation factors at different column temperature were determined with some qualitative trends derived. A compensation effect was observed for these compounds where there exists an approximately linear relationship between the enantiomeric differences in enthalpic and entropic energies.
Ching
C B
CB
Department of Chemical Engineering, National University of Singapore.
Lim
B G
BG
Lee
E J
EJ
Ng
S C
SC
D000319:Adrenergic beta-Antagonists / Q000032:analysis*; D002482:Cellulose; D002851:Chromatography, High Pressure Liquid; D013237:Stereoisomerism; D013696:Temperature
D000319:Adrenergic beta-Antagonists; D002482:Cellulose