Adjunctive therapy in bacterial meningitis--what make sense?
Bacterial meningitis continues to cause morbidity and mortality despite bactericidal antibiotic therapy. Experimental studies of pathophysiology reveal the bacteria and their surface components within cerebrospinal fluid (CSF) induce the release of inflammatory cytokines that promote CSF inflammation, injure the cerebral microvasculature and cause brain edema. Adjunctive corticosteroids reduce inflammation, ameliorate the pathophysiology, and improve neurologic outcome in children. Practical recommendations are made for children and selected adults regarding current and future directions of adjunctive therapy.
Quagliarello
V
V
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510.
Scheld
W M
WM
D000818:Animals; D001812:Blood-Brain Barrier; D003907:Dexamethasone / Q000627:therapeutic use*; D006801:Humans; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid / Q000188:drug therapy*
D003907:Dexamethasone