Stimulation of rat pituitary tumoral cell proliferation in vitro by tetra- and pentagastrin.
The effects of the active gastrin fragments, penta- and tetragastrin on the incorporation of tritiated thymidine into the rat pituitary tumoral cells were investigated in vitro. The significant stimulation of 3H-thymidine incorporation was observed as an effect of the investigated substances. The putative role of gastrin as an autocrine growth factor active in pituitary tumorigenesis was discussed.
Institute of Endocrinology, Medical University of Lódź, Poland.
M
M
Pawlikowski
J
J
Kunert-Radek
K D
KD
Döhler
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D005260:Female; D010418:Pentagastrin / Q000494:pharmacology*; D010911:Pituitary Neoplasms / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013758:Tetragastrin / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D013758:Tetragastrin; D010418:Pentagastrin