Gamma-COP, a coat subunit of non-clathrin-coated vesicles with homology to Sec21p.
Constitutive secretory transport in eukaryotes is likely to be mediated by non-clathrin-coated vesicles, which have been isolated and characterized [(1989) Cell 58, 329-336; (1991) Nature 349, 215-220]. They contain a set of coat proteins (COPs) which are also likely to exist in a preformed cytosolic complex named coatomer [(1991) Nature 349, 248-250]. From peptide sequence and cDNA structure comparisons evidence is presented that one of the subunits of coatomer, gamma-COP, is a true constituent of non-clathrin-coated vesicles, and that gamma-COP is related to sec 21, a secretory mutant of the yeast Saccharomyces cervisiae.
Institut für Biochemie I, Universität Heidelberg, Germany.
G
G
Stenbeck
R
R
Schreiner
D
D
Herrmann
S
S
Auerbach
F
F
Lottspeich
J E
JE
Rothman
F T
FT
Wieland
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001692:Biological Transport; D001921:Brain; D002417:Cattle; D003001:Cloning, Molecular; D004721:Endoplasmic Reticulum; D011992:Endosomes / Q000737:chemistry*; D005656:Fungal Proteins / Q000235:genetics; D006056:Golgi Apparatus; D008565:Membrane Proteins / Q000235:genetics* / Q000302:isolation & purification; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid
D005656:Fungal Proteins; D008565:Membrane Proteins