Ribosome-inactivating proteins from plants: present status and future prospects.
Plant ribosome-inactivating proteins (RIPs) are N-glycosidases which cleave the N-glycosidic bond of adenine in a specific ribosomal RNA sequence. Most commonly RIPs are single-chain proteins (type 1 RIPs), but some (type 2 RIPs) possess a galactose-specific lectin domain that binds to cell surfaces. The latter RIPs are potent toxins, the best known of which is ricin. RIPs have antiviral and abortifacient activities, and, in a widespread application, can also be linked to antibodies or ligands to form immunotoxins or conjugates specifically toxic to a given type of cell.
Dipartimento di Patologia Sperimentale, Università di Bologna, Italy.
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Stirpe
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Barbieri
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Battelli
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Soria
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Lappi
D000225:Adenine / Q000378:metabolism; D000595:Amino Acid Sequence; D001483:Base Sequence; D005544:Forecasting; D006801:Humans; D008969:Molecular Sequence Data; D010940:Plant Proteins / Q000737:chemistry / Q000494:pharmacology*; D012270:Ribosomes; D012689:Sequence Homology, Nucleic Acid
D010940:Plant Proteins; D000225:Adenine