Eccrine syringofibroadenoma: a case report with analysis of cytokeratin expression.
A 56-year-old man presented with a 30-year history of a slowly enlarging lesion on the sole of his right foot. A biopsy showed an anastomosing network of small cuboidal cells with the formation of occasional sweat ductal lumina and a marked fibrovascular stroma. The histological findings were interpreted as consistent with the diagnosis of an eccrine syringofibroadenoma. Using immunohistochemistry all the tumour cells were positively stained by the pan-cytokeratin antibody Lu-5 and an antibody to the cytokeratins 1/5/10/11. In addition the luminal ductal cells expressed cytokeratin 19 and CEA. Tumour cells were negative for cytokeratins 1, 7, 8, 13 and 18 and did not express vimentin and GCDFP-15. The results indicate that the eccrine syringofibroadenoma is differentiated towards the dermal eccrine duct.
Department of Dermatology, University of Munich, Germany.
F
F
Eckert
M
M
Nilles
M
M
Altmannsberger
D006607:Adenoma, Sweat Gland / Q000737:chemistry / Q000473:pathology*; D005534:Foot Diseases / Q000473:pathology; D006801:Humans; D007633:Keratins / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D013544:Sweat Gland Neoplasms / Q000737:chemistry / Q000473:pathology*
D007633:Keratins