Localization of growth arrest-specific genes on mouse chromosomes 1, 7, 8, 11, 13, and 16.
Growth arrest in NIH3T3 cells is associated with increased expression of a variety of mRNAs, several of which have been isolated as cDNA clones. Six of these growth arrest-specific (Gas) genes were mapped by following the inheritance of DNA restriction fragment length variants (RFLVs) associated with them in panels of recombinant inbred (RI) strains of mice and in the progeny of backcrosses both between laboratory mouse strains and between a laboratory strain and Mus spretus. The six genes are unlinked. Gas-1 maps to Chromosome (Chr) 13, Gas-2 to Chr 7, Gas-3 to Chr 11, Gas-4 to Chr 16, Gas-6 to Chr 8, and Gas-10 to Chr 1.
Division of Experimental Oncology D, Istituto Nazionali Tumori, Milano, Italy.
M P
MP
Colombo
A
A
Martinotti
T A
TA
Howard
C
C
Schneider
P
P
D'Eustachio
M F
MF
Seldin
D016475:3T3 Cells; D000818:Animals; D015139:Blotting, Southern; D002455:Cell Division / Q000235:genetics*; D002874:Chromosome Mapping; D008040:Genetic Linkage; D051379:Mice; D012150:Polymorphism, Restriction Fragment Length