Inhibition of development of Kaposi's sarcoma-related lesions by a bacterial cell wall complex.
In vitro and in vivo model systems for the study of human immunodeficiency virus (HIV)-associated Kaposi's sarcoma (KS) were used to evaluate compounds for their potential as therapeutic agents. A sulfated polysaccharide-peptidoglycan compound (SP-PG) produced by bacteria controlled the in vitro growth of acquired immunodeficiency syndrome (AIDS)-associated, KS-derived spindle-shaped cells (AIDS-KS cells) at noncytotoxic concentrations. Angiogenesis induced by AIDS-KS cells in the chicken chorioallantoic membrane assay was blocked by SP-PG, which also inhibited the vascular hyperpermeability response and the angiogenesis associated with the induction of KS-like lesions that develop after subcutaneous inoculation of AIDS-KS cells into nude mice. Suramin, pentosan polysulfate, and interferon alpha, which are currently in use for therapy of KS, were either less effective than SP-PG or much more cytotoxic, or both.
Department of Internal Medicine, University of Southern California, Los Angeles 90033.
S
S
Nakamura
S
S
Sakurada
S Z
SZ
Salahuddin
Y
Y
Osada
N G
NG
Tanaka
N
N
Sakamoto
M
M
Sekiguchi
R C
RC
Gallo
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000818:Animals; D001173:Arthrobacter; D001192:Arylsulfatases; D002199:Capillary Permeability / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D010457:Peptidoglycan; D011134:Polysaccharides / Q000494:pharmacology*; D012514:Sarcoma, Kaposi / Q000209:etiology / Q000473:pathology*; D014407:Tumor Cells, Cultured
D010457:Peptidoglycan; D011134:Polysaccharides; D001192:Arylsulfatases