Antioxidant activity of flavonoids from Sideritis javalambrensis.
Five flavonoid glycosides, 4'-O-methylisoscutellarein 7-O-[6"'-acetylallopyranosyl(1----2)glucopyranoside], 4'-O-methylisoscutellarein 7-O-allopyranosyl(1----2)glucopyranoside, 3'-hydroxy-4'-O-methylisoscutellarein 7-O-[6"'-acetylallopyranosyl(1----2) glucopyranoside], and hypolaetin-8-glucoside have been isolated from Sideritis javalambrensis aerial parts and identified by standard methods. These glycosides have been tested for their antioxidant properties alongside other 7,8-substituted flavonoids using FeSO4/cysteine-induced microsomal lipid peroxidation. Superoxide scavenging activity was assessed in the nitroblue tetrazolium test. Among this series of flavonoids, hypolaetin-8-glucoside is the most potent inhibitor of nonenzymic lipid peroxidation. The antiperoxidative activity of these flavonoids may be related to their superoxide scavenging ability.
Departmento de Farmacología, Facultad de Farmacia, Valencia, Spain.
J L
JL
Rios
S
S
Mañez
M
M
Paya
M J
MJ
Alcaraz
D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D002240:Carbohydrate Sequence; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D008969:Molecular Sequence Data; D010944:Plants / Q000737:chemistry
D000975:Antioxidants; D005419:Flavonoids