The human vitronectin (complement S-protein) gene maps to the centromeric region of 17q.
Vitronectin (complement S-protein, serum-spreading factor, epibolin) is a multifunctional glycoprotein that mediates cell-to-substrate adhesion, inhibits the cytolytic action of the terminal complement cascade in vitro and binds to several serine protease inhibitors of the serpin family, viz. antithrombin III, plasminogen activator inhibitor I (PAI-1) and II (PAI-2), heparin cofactor II and protease nexin. Using high resolution fluorescence in situ hybridization, we mapped the vitronectin gene to the centromeric region of the long arm of chromosome 17 corresponding to 17q11. The location was confirmed by co-hybridization with the centromere-specific alphoid probe p17H8 (D17Z1) and by chromosome banding with 4,6-diamidino-2-phenylindole-dihydrochloride (DAPI). None of the previously mapped genes that are evolutionary related to vitronectin are located on the same chromosome.
Deutsches Krebsforschungszentrum, Heidelberg, Federal Republic of Germany.
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Fink
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Jenne
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Lichter
D002503:Centromere / Q000502:physiology*; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D003360:Cosmids; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D015342:DNA Probes; D005091:Exons; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D008677:Metaphase; D019096:Vitronectin
D015342:DNA Probes; D006023:Glycoproteins; D019096:Vitronectin; D004247:DNA