Enhancement of pentazocine analgesia by clonidine.
Opiate-adrenergic interactions were investigated by studying the effect of the selective alpha 2-adrenergic agonist, clonidine, on the analgesia produced by intravenous placebo and by the predominantly kappa-opiate agonist, pentazocine, in patients with dental postoperative pain. Clonidine did not affect the pain level when administered with intravenous placebo. When administered with pentazocine, clonidine caused a statistically significant increase in pentazocine analgesia. Comparison is made to other opiate-adrenergic interactions and possible mechanisms are discussed.
Gordon
Newton C
NC
Departments of Anatomy, Medicine and Oral and Maxillofacial Surgery, and Division of Neurosciences, University of California, San Francisco, CAUSA Department of Emergency Medicine, Kaiser-Permanente Medical Center, Hayward, CAUSA.
Heller
Philip H
PH
Levine
Jon D
JD
D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage*; D000698:Analgesia; D000704:Analysis of Variance; D003000:Clonidine / Q000008:administration & dosage*; D004311:Double-Blind Method; D004347:Drug Interactions; D006801:Humans; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy* / Q000503:physiopathology; D010423:Pentazocine / Q000008:administration & dosage*; D014081:Tooth Extraction
D000316:Adrenergic alpha-Agonists; D003000:Clonidine; D010423:Pentazocine