Wilms' tumour: reconciling genetics and biology.
Wilms' tumour, a paediatric malignancy of the kidney, is a striking example of the relationship between aberrant development and cancer. Several different genetic loci have been implicated in the aetiology of the tumour; genomic imprinting also plays a role. One Wilms' tumour predisposition gene (WT1), encoding a zinc finger protein, is expressed in a limited set of tissues, including developing nephrons and gonads. The biology and genetics of Wilms' tumour underline the developmental relationship between kidneys and gonads.
MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK.
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Hastie
D000015:Abnormalities, Multiple / Q000235:genetics; D015783:Aniridia / Q000235:genetics; D002880:Chromosomes, Human, Pair 11; D003456:Cryptorchidism / Q000235:genetics; D004268:DNA-Binding Proteins / Q000502:physiology; D005260:Female; D018507:Gene Expression Regulation, Developmental; D015972:Gene Expression Regulation, Neoplastic; D016162:Genes, Wilms Tumor; D006066:Gonads / Q000196:embryology; D006801:Humans; D007021:Hypospadias / Q000235:genetics; D007668:Kidney / Q000196:embryology*; D007680:Kidney Neoplasms / Q000196:embryology / Q000235:genetics*; D008297:Male; D009857:Oncogenes; D017384:Sequence Deletion; D013577:Syndrome; D014157:Transcription Factors / Q000502:physiology; D025721:WT1 Proteins; D009396:Wilms Tumor / Q000196:embryology / Q000235:genetics*; D016335:Zinc Fingers
D004268:DNA-Binding Proteins; D014157:Transcription Factors; D025721:WT1 Proteins