Gastrulation in the mouse: the role of the homeobox gene goosecoid.
Mouse goosecoid is a homeobox gene expressed briefly during early gastrulation. Its mRNA accumulates as a patch on the side of the epiblast at the site where the primitive streak is first formed. goosecoid-expressing cells are then found at the anterior end of the developing primitive streak, and finally in the anteriormost mesoderm at the tip of the early mouse gastrula, a region that gives rise to the head process. Treatment of early mouse embryos with activin results in goosecoid mRNA accumulation in the entire epiblast, suggesting that a localized signal induces goosecoid expression during development. Transplantation experiments indicate that the tip of the murine early gastrula is the equivalent of the organizer of the amphibian gastrula.
Molecular Biology Institute, University of California, Los Angeles 90024-1737.
M
M
Blum
S J
SJ
Gaunt
K W
KW
Cho
H
H
Steinbeisser
B
B
Blumberg
D
D
Bittner
E M
EM
De Robertis
D028341:Activins; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004268:DNA-Binding Proteins / Q000032:analysis*; D004627:Embryonic Induction / Q000187:drug effects / Q000235:genetics*; D005775:Gastrula / Q000187:drug effects; D015870:Gene Expression; D005801:Genes, Homeobox; D051956:Goosecoid Protein; D018398:Homeodomain Proteins; D007265:Inhibins / Q000494:pharmacology; D008648:Mesoderm / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000032:analysis; D012097:Repressor Proteins; D014157:Transcription Factors; D014981:Xenopus / Q000196:embryology
D004268:DNA-Binding Proteins; D051956:Goosecoid Protein; C497993:Gsc protein, mouse; D018398:Homeodomain Proteins; D012333:RNA, Messenger; D012097:Repressor Proteins; D014157:Transcription Factors; D028341:Activins; D007265:Inhibins