Effect of doxapram on neostigmine evoked antagonism of vecuronium neuromuscular block.
We have examined the effect of doxapram on neostigmine-evoked antagonism of vecuronium neuromuscular block in a double-blind study in anaesthetized patients. Neuromuscular transmission was measured with a Datex Relaxograph. The mean time to recovery of the first contraction of the train-of-four (T1) from 25% to 75% was significantly longer in the presence of doxapram (138 (SEM 21) s; n = 23) than in its absence (95 (13) s; n = 29) (P = 0.014). The recovery of the train-of-four ratio was prolonged also in the presence of doxapram, although this difference was not statistically significant.
University Department of Anaesthesia, Manchester Royal Infirmary.
M
M
Orlowski
B J
BJ
Pollard
D000328:Adult; D000768:Anesthesia, General; D003864:Depression, Chemical; D004311:Double-Blind Method; D004315:Doxapram / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006024:Glycopyrrolate / Q000494:pharmacology; D006801:Humans; D009119:Muscle Contraction / Q000187:drug effects; D009388:Neostigmine / Q000494:pharmacology*; D013997:Time Factors; D014673:Vecuronium Bromide / Q000037:antagonists & inhibitors*
D009388:Neostigmine; D014673:Vecuronium Bromide; D004315:Doxapram; D006024:Glycopyrrolate