Retrovirus-mediated gene expression in mammalian cells.
Significant advances have been made in precisely defining the elements in the Moloney murine leukemia virus genome responsible for tissue-restricted expression. This knowledge should lead to improved expression vectors for gene transfer in mammalian cells. In the past year, retrovirus-mediated gene expression in a diverse range of cell types has been reported. These cells have been used to study gene transfer relevant to a range of inherited diseases.
Osborne
W R
WR
University of Washington, Seattle.
D000818:Animals; D003001:Cloning, Molecular / Q000379:methods; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D008322:Mammals; D008979:Moloney murine leukemia virus / Q000235:genetics*