[Pharmacology of excitatory amino acid receptors].
L-Glutamate is an excitatory neurotransmitter at many synapses in the animal, and causes neuronal damage in the mammalian neuron. Glutamate receptors have been classified into at least five types: NMDA-, kainate-, AMPA-, and L-AP4-type ionotropic receptors and metabotropic glutamate receptors. Recently new glutamate agonists have been introduced into the pharmacological study in neuroscience research. They are methoxyphenylkainoids, acromelic acids and 2-(carboxycyclopropyl)glycine (CCG). A methoxyphenylkainoid and acromelic acid A are one of the most potent excitants in the mammalian central neuron. These compounds should provide valuable pharmacological probes for analysis of functions of excitatory amino acids.
Shinozaki
H
H
Pharmacology Section, Tokyo Metropolitan Institute of Medical Science, Japan.
D000818:Animals; D005971:Glutamates / Q000378:metabolism / Q000502:physiology*; D018698:Glutamic Acid; D006801:Humans; D007608:Kainic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D017470:Receptors, Glutamate / Q000145:classification* / Q000378:metabolism / Q000502:physiology
D005971:Glutamates; D017470:Receptors, Glutamate; D018698:Glutamic Acid; C051743:acromelic acid A; D007608:Kainic Acid