S-fimbriae mediated adhesion of Escherichia coli to human buccal epithelial cells is age independent.
S-fimbriated Escherichia coli, which cause sepsis and meningitis in the newborn, bind to sialic acid-containing glycoprotein structures on the surface of human buccal epithelial cells. The dependence of this binding on host age was examined. S-fimbriated E. coli adhered in comparable numbers to cells in newborns, infants, children and adults (23.0 +/- 8.6; 23.1 +/- 11.5; 24.7 +/- 7.9; 28.9 +/- 8.8). Thus, the increased susceptibility of neonates to infections caused by S-fimbriated E. coli cannot be explained by enhanced adhesion to epithelial cells.
Universitäts- Kinderklinik Düsseldorf, Germany.
H
H
Schroten
M
M
Steinig
R
R
Plogmann
F G
FG
Hanisch
J
J
Hacker
P
P
Herzig
V
V
Wahn
D000367:Age Factors; D001422:Bacterial Adhesion / Q000502:physiology*; D001665:Binding Sites; D002610:Cheek; D002648:Child; D002675:Child, Preschool; D015169:Colony Count, Microbial; D004848:Epithelium / Q000382:microbiology; D004926:Escherichia coli / Q000502:physiology*; D005069:Evaluation Studies as Topic; D010861:Fimbriae, Bacterial; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009092:Mucous Membrane / Q000382:microbiology; D012795:Sialoglycoproteins / Q000502:physiology*
D012795:Sialoglycoproteins