Production of recombinant products in yeasts: a review.
This paper reviews the use of yeasts to produce heterologous proteins via the development of transformation systems. The ability to genetically engineer yeast cells has many advantages over prokaryotic systems. Yeasts are already well established in fermentation procedures, are able to secrete glycosylated and modified proteins to render the proteins biologically active, and yeasts do not secrete toxic chemicals. With the techniques available it is possible to explore yeasts as hosts for the expression and secretion of commercially-useful proteins.
Russell
C
C
Department of Biotechnology, Massey University, Palmerston North, New Zealand.
Mawson
J
J
Yu
P L
PL
D005822:Genetic Vectors; D011499:Protein Processing, Post-Translational; D011994:Recombinant Proteins / Q000096:biosynthesis*; D014170:Transformation, Genetic; D015003:Yeasts / Q000235:genetics*
D011994:Recombinant Proteins