Environmental regulation of bacterial virulence--implications for vaccine design and production.
There is now overwhelming evidence that many of the crucial virulence determinants of pathogenic bacteria are environmentally regulated and expressed only under certain conditions. Much progress is currently being made in identifying these factors and in understanding the molecular mechanisms controlling their production. This information is crucial for the understanding of microbial pathogenicity and it has important practical implications for vaccine design and production.
National Institute for Biological Standards and Control, Potters Bar, Herts, UK.
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D001419:Bacteria / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity*; D001428:Bacterial Vaccines / Q000302:isolation & purification*; D001709:Biotechnology; D002118:Calcium / Q000378:metabolism; D004777:Environment; D007501:Iron / Q000378:metabolism; D009995:Osmosis; D013696:Temperature; D014614:Vaccines, Synthetic / Q000302:isolation & purification; D014774:Virulence
D001428:Bacterial Vaccines; D014614:Vaccines, Synthetic; D007501:Iron; D002118:Calcium