Early appearance of tyrosine hydroxylase immunoreactivity in the retina of human embryos.
In the retina of 6 post-ovulatory week old human embryos, tyrosine hydroxylase (TH) immunoreactivity is expressed in retinoblasts in the peripheral retina, and ganglion-like cells with an axon in the optic nerve in the posterior retina. This is the first report on the expression of a catecholamine marker in a sub-population of migrating retinoblasts. Since in the adult retina the only TH+ cells are a sub-population of amacrine cells, the expression of this enzyme in some ganglion-like cells must represent either a transient developmental event, or indicate that these cells subsequently undergo transformation through axonal degeneration.
INSERUM U-86, Laboratoire de Neurocytologie Oculaire, Paris, France.
C
C
Versaux-Botteri
C
C
Verney
N
N
Zecevic
J
J
Nguyen-Legros
D000029:Abortion, Legal; D015415:Biomarkers; D004622:Embryo, Mammalian; D005260:Female; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D012160:Retina / Q000166:cytology / Q000196:embryology* / Q000201:enzymology*; D012165:Retinal Ganglion Cells / Q000166:cytology / Q000201:enzymology / Q000502:physiology; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis / Q000378:metabolism*
D015415:Biomarkers; D014446:Tyrosine 3-Monooxygenase