[Pharmacology aspects of glaucoma].
The aim of all treatment for glaucoma is to lower intra-ocular pressure. During the past decade, the short-action cholinergic agonists, eserine and pilocarpine, that have been used for over a hundred years have been replaced as the drugs of choice by beta-blockers, in particular the non-selective beta-blocker, timolol maleate. Of the series of drugs developed in recent years for the treatment of glaucoma, two types--carbonic anhydrase inhibitors and prostaglandin analogues--are undergoing phase III trials. The article provides an account of the pharmacological basis of glaucoma treatment today and in the immediate future.
Institutionen för oftalmiatrik, Ogonkliniken, Akademiska Sjukhuset, Uppsala.
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D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002257:Carbonic Anhydrase Inhibitors / Q000627:therapeutic use; D003000:Clonidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D004837:Epinephrine / Q000627:therapeutic use; D005901:Glaucoma / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D010277:Parasympathomimetics / Q000627:therapeutic use; D011465:Prostaglandins, Synthetic / Q000627:therapeutic use
D000316:Adrenergic alpha-Agonists; D000319:Adrenergic beta-Antagonists; D002121:Calcium Channel Blockers; D002257:Carbonic Anhydrase Inhibitors; D010277:Parasympathomimetics; D011465:Prostaglandins, Synthetic; C016986:apraclonidine; D003000:Clonidine; D004837:Epinephrine
Glaukomets farmakologi.