Pharmacokinetics of dipipanone after a single oral dose.
A single oral dose of Diconal (dipipanone HCl 10 mg, cyclizine HCl 30 mg) was given to six volunteers. The mean peak plasma dipipanone concentration was 29 ng ml-1, the time to peak plasma concentration was 1-2 h, the mean elimination half-life was 3.5 h and the mean AUC was 156 ng ml-1 min. Less than 1% of the dose was excreted in urine unchanged over 24 h.
Department Forensic Medicine and Toxicology, Charing Cross and Westminster Medical School, London.
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Paterson
D000284:Administration, Oral; D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008691:Methadone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
D000701:Analgesics, Opioid; D008691:Methadone; C007527:dipipanone