[The significance of synergism between cervical infections and prostaglandins in inducing preinduction priming in the 3rd trimester of pregnancy].
The length of labour and foetal trauma could be significantly reduced by reduction of cervical resistance in the cause of labour. It is well known that the most effective way of priming is by prostaglandins. Microorganisms of cervico-vaginal flora, with or without inflammatory component, can produce factors which can create predisposition for preterm delivery. Namely, increased levels of prostaglandins E2 and F2 alpha could be noticed in amniotic fluids, compared with these levels in pregnant women without signs of infection. The study included 60 parturients with low Bishop score (less then 5), with average gestational age of 40.5 weeks. Group A: Prepidil gel with 0.5 mg of prostaglandin E2 was applied to cause priming. Group B: Half of doses of Prepidil gel (0.25 mg) was applied to the 30 patients with clinical signs and with positive laboratory findings of cervical infection. After 12 hours all patients were induced with oxytocin. All obstetrically important parameters were closely followed in the course of priming and induction. Presence of cervical infection could be beneficial, because priming can be produced with half of doses of prostaglandin, which means medical (reduction of side-effects and dangers of hyperstimulation) and significant economical benefits regarding the high price of prostaglandins.
Bukvić
I
I
UMC Ginekolosko-akuserska klinika, Sarajevo.
Salaka
U
U
Sehović
Z
Z
Visnjevac
V
V
Simić
M
M
D000328:Adult; D015232:Dinoprostone / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007239:Infections / Q000503:physiopathology*; D007751:Labor, Induced; D007743:Labor, Obstetric / Q000502:physiology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000503:physiopathology*; D011263:Pregnancy Trimester, Third; D011453:Prostaglandins / Q000502:physiology*; D002577:Uterine Cervical Diseases / Q000382:microbiology / Q000503:physiopathology*
D011453:Prostaglandins; D015232:Dinoprostone
Znacaj sinergizma cervikalne infekcije i prostaglandina u izazivanju preindukcionog priminga u III trimestru trudnoće.