The extraction of penicillin G with aliphatic amines in organic solvents of different polarities.
The equilibrium constants of the extraction, the molar ratios of amines to penicillin G in the extract and the bonding structures of the extracted species were studied with chemical analysis and the absorbance shift of FT-IR spectra of the functional groups in penicillin G. Extraction of penicillin G from the filtrate of fermentation broth indicates that amines will be difficult to use as the industrial solvent for the production of penicillin G because of the poor quality of the final crystalline product obtained and the difficulties involved in the stripping and solvent recovery.
Yang
Z F
ZF
Institute of Chemical Metallurgy, Academia Sinica, Beijing, People's Republic of China.
Yu
S Q
SQ
Chen
J Y
JY
D000588:Amines; D001554:Benzene; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005285:Fermentation; D006863:Hydrogen-Ion Concentration; D010400:Penicillin G / Q000302:isolation & purification*; D012997:Solvents
D000588:Amines; D012997:Solvents; D001554:Benzene; D010400:Penicillin G