Detection of subpigment epithelial neovascularisation in cases of retinal pigment epithelial detachments: a review of the Moorfields treatment trial.
The entry angiograms of 42 eyes with detachment of the retinal pigment epithelium in a treatment trial of laser photocoagulation were reviewed in a masked fashion by three observers in order to assess the possible presence of subpigment epithelial neovascularisation. Vascularity or avascularity was designated with reference to a list of clues believed to imply the presence of subpigment epithelial neovascularisation. As a predictor of outcome the initial assessment achieved a sensitivity and specificity of 77% and 82% respectively. Despite notable parity of the degree of sensitivity and specificity among the three observers, full agreement on the initial assessments was reached in only 23 eyes (55%), 10 with vascular and 13 with avascular outcome. Of these, only one eye which developed new vessels after 4 years had an outcome which differed from that predicted by classification of the entry angiograms.
Retinal Diagnostic Department, Moorfields Eye Hospital, London.
S
S
Pagliarini
M J
MJ
Barondes
I H
IH
Chisholm
A M
AM
Hamilton
A C
AC
Bird
D000368:Aged; D000369:Aged, 80 and over; D005451:Fluorescein Angiography; D006801:Humans; D008028:Light Coagulation; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000473:pathology*; D010857:Pigment Epithelium of Eye / Q000098:blood supply; D011379:Prognosis; D012163:Retinal Detachment / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D012171:Retinal Vessels / Q000473:pathology*; D013997:Time Factors