Alterations induced by fascioliasis and cirrhosis on the biliary excretion of cefmetazole in Wistar rats.
1. Alterations induced by fascioliasis and cirrhosis on the biliary excretion of cefmetazole have been studied in Wistar rats. 2. Both infestation with Fasciola hepatica and experimental cirrhosis originated a significant decrease in the biliary excretion and in bile flow increase induced by the drug. 3. Administration of the beta-lactam antibiotic induced a lower degree of uncoupling of biliary lipid secretion in the cirrhotic and fasciolotic animals, but the effect was evident in all experimental groups.
Department of Physiology, Pharmacology and Toxicology, University of León, Spain.
P
P
Lopez
L A
LA
Garcia-Pardo
J
J
Gonzalez-Gallego
P
P
Gonzalez
M J
MJ
Tuñon
D000818:Animals; D001646:Bile / Q000378:metabolism*; D015311:Cefmetazole / Q000493:pharmacokinetics* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D003720:Densitometry; D005211:Fascioliasis / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D015311:Cefmetazole