Fibrohistiocytic differentiation in capillary hemangioblastoma.
Seven cases of capillary hemangioblastoma from the cerebellum and spinal cord were studied by immunohistochemical methods to determine the origin of the stromal cells. A subpopulation of factor XIIIa-positive tumor cells was a constant feature in hemangioblastomas. These stellate or spindle-shaped cells transformed into typical vacuolated stromal cells. Factor VIII-related antigen was limited to the vascular endothelium. Glial fibrillary acidic protein was present only in entrapped astrocytes. Staining for alpha-1-antitrypsin (alpha 1AT) and alpha-1-antichymotrypsin (alpha 1 ACT) was occasionally observed in stromal cells. It was concluded that the factor XIIIa-positive stromal cells in capillary hemangioblastoma indicate fibrohistiocytic differentiation, which is part of the differentiation spectrum of hemangiopericytomas.
Nemes
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Department of Pathology, University Medical School of Debrecen, Hungary.
D000328:Adult; D015415:Biomarkers; D002528:Cerebellar Neoplasms / Q000098:blood supply / Q000737:chemistry / Q000473:pathology*; D005260:Female; D006394:Hemangiosarcoma / Q000098:blood supply / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D013120:Spinal Cord Neoplasms / Q000098:blood supply / Q000737:chemistry / Q000473:pathology*; D011503:Transglutaminases / Q000032:analysis*
D015415:Biomarkers; D011503:Transglutaminases