[Evaluation of the effect of proton pump inhibitors on stomal ulcer].
Four reports on proton pump inhibitors related to the clinical effects on stomal ulcer were reviewed. Two reports were on omeprazole and the other two on lansoprazole, carried out in the pre-marketing stage. They are compared with two reports on H2-receptor antagonists (famotidine and ranitidine), which were also done in the pre-marketing stage. It appears that the proton pump inhibitors bring more rapid ulcer healing than H2-receptor antagonists without severe side effects, and there seems to be no difference in clinical effect between omeprazole and lansoprazole.
Yukawa
K
K
Yukawa Gastrointestinal Hospital.
Yukawa
E
E
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D004341:Drug Evaluation; D016099:Endoscopy, Gastrointestinal; D017506:H(+)-K(+)-Exchanging ATPase; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D064747:Lansoprazole; D009853:Omeprazole / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*; D010437:Peptic Ulcer / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D006635:Histamine H2 Antagonists; D064747:Lansoprazole; D000251:Adenosine Triphosphatases; D017506:H(+)-K(+)-Exchanging ATPase; D009853:Omeprazole