The effect of brassica vegetable consumption on caffeine metabolism in humans.
Ten healthy volunteers were used in two studies investigating the effect of short-term Brassica consumption on caffeine metabolism. In the first study volunteers were given three Brassica-containing meals, the last one 3 h prior to caffeine administration. In the second study volunteers were given two Brassica-containing meals and then fasted overnight before caffeine administration. In both studies the mean plasma half-life of caffeine was reduced by approximately 20% following a Brassica diet, suggesting that Brassica vegetables stimulate caffeine metabolism. When caffeine was given 3 h after the last meal, plasma caffeine concentrations over 6 h, were increased by up to 27% on the Brassica diet compared to controls. This may be due to a transient increased permeability of the intestine to caffeine, immediately following Brassica consumption. This effect was not seen in the second study where there was a 12-h period between the last meal and caffeine administration. There was large interindividual variation in the effect of the Brassica diet on caffeine metabolism.
Department of Clinical Pharmacology, University College London, Rayne Institute, UK.
R E
RE
McDanell
L A
LA
Henderson
K
K
Russell
A E
AE
McLean
D000284:Administration, Oral; D000328:Adult; D001937:Brassica; D002110:Caffeine / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics; D004032:Diet; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged
D002110:Caffeine