Modification of the rat uterine response to oestrogen and tamoxifen by thromboxane antagonists.
1. The thromboxane receptor antagonists EP092, AH23848 and BM 13.505 were used to investigate the role of thromboxane in the uterotrophic response to oestradiol and tamoxifen. 2. The parameters examined were uterine blood flow (measured by the microsphere technique), uterine wet and dry weights and the concentrations of cytosolic and nuclear oestrogen receptors. 3. Only EP092 potentiated the hyperaemic response to oestrogen but all three thromboxane antagonists inhibited oestradiol-stimulated uterine growth. This inhibition was accompanied by a decrease in nuclear oestrogen receptor concentration. 4. The uterotrophic response to tamoxifen was unaffected by the thromboxane antagonists. 5. The mechanism by which the thromboxane antagonists may be exerting their growth inhibitory effect is discussed, although, whether this effect can be attributed to blockade of thromboxane receptors or to some other mechanism is not clear from this study.
Postgraduate School of Studies in Pharmacology, University of Bradford, West Yorkshire.
M B
MB
Kerr
K
K
Marshall
J
J
Senior
D000818:Animals; D001713:Biphenyl Compounds / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D009929:Organ Size / Q000187:drug effects; D010648:Phenylacetates / Q000494:pharmacology; D011465:Prostaglandins, Synthetic / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011960:Receptors, Estrogen / Q000032:analysis / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects; D013449:Sulfonamides / Q000494:pharmacology; D013629:Tamoxifen / Q000494:pharmacology*; D013931:Thromboxanes / Q000037:antagonists & inhibitors*; D014599:Uterus / Q000098:blood supply / Q000187:drug effects*
D001713:Biphenyl Compounds; D010648:Phenylacetates; D011465:Prostaglandins, Synthetic; D011960:Receptors, Estrogen; D013449:Sulfonamides; D013931:Thromboxanes; D013629:Tamoxifen; D004958:Estradiol; C046926:AH 23848; C045332:EP 092; C051762:daltroban