Genetic heterogeneity of early-onset familial breast cancer.
A gene for early-onset familial breast cancer has recently been mapped to the chromosome 17q12-23 region. In order to confirm the gene location, we have tested an extensive early-onset breast cancer family with 4 markers in this chromosome region. Linkage was negative with all 4 markers. This study suggests that there is genetic heterogeneity among early-onset breast cancer families.
Oncology-Genetics Unit, Centre Léon Bérard, Lyon, France.
H
H
Sobol
S
S
Mazoyer
S A
SA
Narod
S A
SA
Smith
D M
DM
Black
P
P
Kerbrat
B
B
Jamot
E
E
Solomon
B A
BA
Ponder
D
D
Guerin
D001483:Base Sequence; D015139:Blotting, Southern; D001943:Breast Neoplasms / Q000235:genetics*; D002886:Chromosomes, Human, Pair 17; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D008126:Lod Score; D008297:Male; D008969:Molecular Sequence Data; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length
D005819:Genetic Markers