Entrapment vectors: a new tool for mammalian genetics.
The use of mouse embryonic stem (ES) cells has facilitated the creation of mouse strains carrying desired genetic alterations. Recently, "entrapment" vectors have been developed to identify and mutate genes active during embryogenesis. These vectors in combination with ES cells may provide an efficient screening strategy to find genes that control mouse development.
Department of Medical Genetics, University of Toronto, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Canada.
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Skarnes
D000818:Animals; D005822:Genetic Vectors; D051379:Mice; D013234:Stem Cells