Study of the mechanism of prostacyclin (PgI2) action on myocardial contractility.
The experiments done on the isolated right ventricle of rat heart suspended in the bath for isolated organs with oxygenated Tyrode's solution showed the PgI2 (2.3 x 10-6 mmol) produced its positive inotropic effect indirectly by promoting both beta-adrenoreceptors and calcium entry through slow calcium channels because this effect could be blocked by propranolol (2.3 x 10-2 mmol - beta-adrenoreceptor blocker) or verapamil (4.3 x 10-3 mmol - slow calcium channel blocker).
Department of Physiology, Medical Faculty, University of Belgrade, Yugoslavia.
M
M
Pavlović
D
D
Petković
M
M
Cvetković
K
K
Zdjelar
V
V
Starcević
O
O
Bosnić
D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000378:metabolism; D011464:Epoprostenol / Q000494:pharmacology*; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D016278:Ventricular Function, Right / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology
D000318:Adrenergic beta-Agonists; D011433:Propranolol; D014700:Verapamil; D011464:Epoprostenol; D002118:Calcium