The dynamics of MS-222 anaesthesia in a marine teleost (Pagrus auratus: Sparidae).
1. MS-222 anaesthesia of the marine teleost Pagrus auratus caused a dose-dependent elevation in haematocrit. 2. At 60 mg/l MS-222 the elevated haematocrit was fully accounted for by erythrocyte swelling, but at 100 mg/l red cell count also increased. 3. Uptake of anaesthetic in all tissues was rapid and the rate of onset of anaesthesia was dose-dependent. 4. Stage III level of anaesthesia (loss of equilibrium) was correlated with critical levels of MS-222 in the blood and brain. 5. The presence of acetylated derivatives of MS-222 in the blood demonstrated degradation of the anaesthetic, and high levels in the liver and kidney suggested that these organs were the sites of drug metabolism.
Department of Zoology, University of Auckland, New Zealand.
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D062365:Aminobenzoates / Q000493:pharmacokinetics*; D000777:Anesthetics / Q000493:pharmacokinetics*; D000818:Animals; D004906:Erythrocyte Count / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects; D006400:Hematocrit; D010473:Perciformes / Q000378:metabolism*
D062365:Aminobenzoates; D000777:Anesthetics; C003636:tricaine