Protein-catalysed protein folding.
A number of proteins, termed chaperonins, have been identified as part of the mechanism of folding other proteins into their biologically active forms. The role of chaperonins appears to be twofold--to prevent illegitimate interactions with other proteins and to facilitate folding, possibly through an energy-dependent, catalytic function. Controlled overexpression of chaperonins may be of therapeutic value in manipulating human immune response and rescuing certain inherited human mutations.
Department of Human Genetics, Yale University School of Medicine, New Haven, CT 06510.
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Horwich
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Neupert
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Hartl
D018834:Chaperonin 60; D018833:Chaperonins; D006360:Heat-Shock Proteins / Q000502:physiology; D011487:Protein Conformation; D011506:Proteins / Q000502:physiology*
D018834:Chaperonin 60; D006360:Heat-Shock Proteins; D011506:Proteins; D018833:Chaperonins