[Histopathologic and histochemical examination of rat liver after prolonged experimental application of potassium bichromate].
The rats were given potassium bichromate (K2Cr2O7) in dose of 2 and 5 mg/kg of body weight and magnesium chloride (MgCl2) in dose of 500 mg/kg for a period of 30 days. The two compounds were also given conjointly (K2Cr2O7-5 mg+MgCl2-500 mg). There were carried out histopathological as well as histochemical examinations of acid phosphatase activity, alkaline phosphatase activity and adenosine triphosphatase activity in the liver. With small doses (2 mg) of potassium bichromate no changes have been stated. With larger doses (5 mg) of potassium bichromate an increase of histochemical reaction to acid phosphatase as well as forming of histopathological changes such as parenchymatous degeneration, steatosis of hepatocytes and their necrobiosis have been observed. There has not been found any protective action of magnesium chloride on the cytotoxic activity of potassium bichromate on the liver cell.
Katedra i Zakład Patomorfologii. Akademia Medyczna w Lublinie.
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F
Woźniak
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Z
Borzecki
Z
Z
Swies
D000135:Acid Phosphatase / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D004334:Drug Administration Schedule; D004347:Drug Interactions; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D015636:Magnesium Chloride / Q000633:toxicity; D008297:Male; D011192:Potassium Dichromate / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
D015636:Magnesium Chloride; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D000251:Adenosine Triphosphatases; D011192:Potassium Dichromate
Badania histopatologiczne i histochemiczne watroby szczura pozostajacego pod wpływem długotrwałego doświadczalnego stosowania dwuchromianu potasu.