Cellular generators of the cortical auditory evoked potential initial component.
Cellular generators of the initial cortical auditory evoked potential (AEP) component were determined by analyzing laminar profiles of click-evoked AEPs, current source density, and multiple unit activity (MUA) in primary auditory cortex of awake monkeys. The initial AEP component is a surface-negative wave, N8, that peaks at 8-9 msec and inverts in polarity below lamina 4. N8 is generated by a lamina 4 current sink and a deeper current source. Simultaneous MUA is present from lower lamina 3 to the subjacent white matter. Findings indicate that thalamocortical afferents are a generator of N8 and support a role for lamina 4 stellate cells. Relationships to the human AEP are discussed.
Steinschneider
M
M
Department of Neurology, Rose F. Kennedy Center, Albert Einstein College of Medicine, Bronx, NY 10461.
Tenke
C E
CE
Schroeder
C E
CE
Javitt
D C
DC
Simpson
G V
GV
Arezzo
J C
JC
Vaughan
H G
HG
D000161:Acoustic Stimulation; D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D008252:Macaca fascicularis; D008297:Male