Latent help to and from H-2 antigens.
An optimized system for probing allo-immunity to major histocompatibility complex (MHC) antigens by means of adoptive transfer is used to confirm and extend previous work showing that naturally occurring class I MHC antigens, while capable of inducing Th activity when presented in combination with other allo-antigens, fail to do so on their own. The Th activity which they do induce develops slowly, after repeated immunizations, and can properly be described as "latent". Latency, or "cripticity" as it is also termed, may help explain how autoimmune disease is initiated.
Imperial Cancer Research Fund Tumour Immunology Unit, University College London.
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Mitchison
D000818:Animals; D000954:Antigens, Surface / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D006183:H-2 Antigens / Q000276:immunology*; D007114:Immunization; D007700:Kinetics; D008213:Lymphocyte Activation; D051379:Mice; D008815:Mice, Inbred Strains; D015778:Minor Histocompatibility Antigens / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D018800:Thy-1 Antigens
D000954:Antigens, Surface; D006183:H-2 Antigens; D015778:Minor Histocompatibility Antigens; D018800:Thy-1 Antigens