Alcoholism and the D2 receptor gene.
The allelic association of the human dopamine D2 receptor gene and alcoholism was evaluated in 20 male alcoholics and 20 controls (sex, race, and geographic place of birth matched). This study further examines the issue of alcoholism severity and A1 allele frequency. No difference in A1 allele frequency was observed between these two groups. Similarly, no relationship between alcoholism severity and A1 frequency within the alcoholics was demonstrated.
Cook
B L
BL
Department of Veterans Affairs Medical Center, Iowa City, Iowa 52246-2208.
Wang
Z W
ZW
Crowe
R R
RR
Hauser
R
R
Freimer
M
M
D000328:Adult; D000437:Alcoholism / Q000150:complications / Q000235:genetics* / Q000503:physiopathology / Q000534:rehabilitation; D000483:Alleles; D015342:DNA Probes; D005787:Gene Frequency / Q000235:genetics*; D005838:Genotype; D006519:Hepatitis, Alcoholic / Q000235:genetics / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D011954:Receptors, Dopamine / Q000235:genetics* / Q000502:physiology; D017448:Receptors, Dopamine D2
D015342:DNA Probes; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2