The effects of clonidine and three 2-imidazoline derivatives on the secretion of protein and some electrolytes by rat submandibular and parotid glands.
1. Three imidazoline analogues of clonidine were potent secretagogues for the parotid and submandibular glands at relatively high doses. 2. Salivation in response to clonidine was completely abolished by prazosin, phentolamine, phenoxybenzamine and dihydroergotamine. 3. The gamma-type of proteins was secreted in response to three of the analogues, whereas with p-aminoclonidine the alpha-type of proteins was secreted by the submandibular gland. 4. Albumin was specifically secreted by the submandibular gland in response to clonidine but not to isoproterenol or phenylephrine.
Department of Oral Biochemistry, Fukuoka Dental College, Japan.
S
S
Shibaike
K
K
Abe
A
A
Okina
T
T
Nishiura
D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects*; D003000:Clonidine / Q000031:analogs & derivatives / Q000494:pharmacology*; D004573:Electrolytes / Q000378:metabolism*; D007093:Imidazoles / Q000494:pharmacology; D008297:Male; D009278:Naphazoline / Q000494:pharmacology; D010306:Parotid Gland / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012471:Salivary Proteins and Peptides / Q000378:metabolism*; D013363:Submandibular Gland / Q000187:drug effects* / Q000378:metabolism
D004573:Electrolytes; D007093:Imidazoles; D012471:Salivary Proteins and Peptides; C016986:apraclonidine; D009278:Naphazoline; D003000:Clonidine; C005810:tetrahydrozoline