Sustained, substantially increased concentration of prostate-specific antigen in the absence of prostatic malignant disease: an unusual clinical scenario.
A 60-year-old man had a persistent, marked increase in the serum concentration of prostate-specific antigen (more than 20 times the upper limit of the reference range) and no identifiable prostatic malignant involvement. To our knowledge, this is the first such case reported in the literature. Possible explanations for this increased value are described, and nonmalignant conditions that can increase serum concentrations of prostate-specific antigen are reviewed.
Mayo Medical School, Mayo Clinic, Rochester, MN 55905.
W J
WJ
Glenski
R S
RS
Malek
J F
JF
Myrtle
J E
JE
Oesterling
D000951:Antigens, Neoplasm / Q000032:analysis*; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000276:immunology*; D017430:Prostate-Specific Antigen; D011469:Prostatic Diseases / Q000175:diagnosis; D011470:Prostatic Hyperplasia / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology
D000951:Antigens, Neoplasm; D017430:Prostate-Specific Antigen