The retinoblastoma protein and cell cycle regulation.
Although the precise function of the retinoblastoma gene product, p110RB1, remains unknown, recent data suggest that it plays a role in the control of cellular proliferation by regulating transcription of genes required for a cell to enter or stay in a quiescent or G0 state, or for progression through the G1 phase of the cell cycle. However, it is difficult to rationalize the expression of p110RB1 in a wide range of tissues with the fact that mutations in the RB1 gene initiate cancers in a limited number of tissues.
Hamel
P A
PA
Department of Medical Genetics, University of Toronto, Canada.
Gallie
B L
BL
Phillips
R A
RA
D000483:Alleles; D000818:Animals; D002453:Cell Cycle / Q000235:genetics / Q000502:physiology*; D002455:Cell Division; D002472:Cell Transformation, Viral; D002675:Child, Preschool; D016213:Cyclins / Q000235:genetics / Q000502:physiology; D005134:Eye Neoplasms / Q000235:genetics; D005656:Fungal Proteins / Q000502:physiology; D016161:Genes, Retinoblastoma; D006801:Humans; D007223:Infant; D051379:Mice; D008957:Models, Genetic; D009856:Oncogene Proteins, Viral / Q000378:metabolism; D009857:Oncogenes; D009858:Oncogenic Viruses / Q000502:physiology; D009928:Organ Specificity; D012175:Retinoblastoma / Q000235:genetics; D016160:Retinoblastoma Protein / Q000235:genetics / Q000502:physiology*; D012568:Schizosaccharomyces / Q000235:genetics / Q000502:physiology; D013045:Species Specificity; D014157:Transcription Factors / Q000378:metabolism
D016213:Cyclins; D005656:Fungal Proteins; D009856:Oncogene Proteins, Viral; D016160:Retinoblastoma Protein; D014157:Transcription Factors