Circulating ICAM-1 levels in serum of uveitis patients.
Intercellular Adhesion Molecule-1 (ICAM-1) is a cytokine-inducible adhesion molecule expressed on cells of multiple lineages at sites of inflammation. Recently a truncated form of ICAM-1 has been discovered to be circulating in serum. This study reports on circulating serum (cICAM-1) levels in 132 uveitis patients (HLA-B 27 pos. acute anterior uveitis (AAU); HLA-B27 neg. anterior uveitis (AU); intermediate uveitis (IU); heterochromic cyclitis Fuchs (HCF); sarcoidosis; Toxoplasmosis). Measurement of circulating ICAM-1 serum levels was performed using a monoclonal antibody based ELISA, with healthy blood donors serving as the control group. Applying multiple variance analysis and the Student Newmann-Keuls test we found a statistically significant elevation of serum cICAM-1 level in the HLA-B 27 neg. AU group (n:31), in the IU group (n:25) and in patients with sarcoidosis (n:18). Serum levels of HLA-B27 pos. AAU patients, patients with HCF and patients suffering from ocular toxoplasmosis did not differ significantly from levels of the control group.
2nd Department of Ophthalmology, University of Vienna, Austria.
E
E
Arocker-Mettinger
L
L
Steurer-Georgiew
M
M
Steurer
V
V
Huber-Spitzy
E
E
Hoelzl
G
G
Grabner
A
A
Kuchar
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000097:blood; D015815:Cell Adhesion Molecules / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005128:Eye Diseases / Q000097:blood; D005260:Female; D015796:HLA-B27 Antigen / Q000097:blood; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D015863:Iridocyclitis / Q000097:blood; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000097:blood; D014126:Toxoplasmosis, Ocular / Q000097:blood; D014605:Uveitis / Q000097:blood*; D014606:Uveitis, Anterior / Q000097:blood; D015867:Uveitis, Intermediate / Q000097:blood
D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D015796:HLA-B27 Antigen; D018799:Intercellular Adhesion Molecule-1