Mapping of the mouse bilirubin UDP-glucuronosyltransferase gene (Gnt-1) to chromosome 1 by restriction fragment length variations.
Restriction endonuclease fragment length variations (RFLVs) were detected by using a rat cDNA probe for the bilirubin UDP-glucuronosyltransferase (UDPGT) gene between two mouse strains, 129/Sv and MOL-MIT. RFLVs of the gene were found by EcoRI and PvuII digestions. From linkage analyses of the three-point cross test using Elo and En-1 as marker genes, the bilirubin UDPGT gene was mapped at position 37 on chromosome 1. Bilirubin and phenol UDPGTs have been suggested to be expressed by a single gene by alternative splicing in human and rat. The mouse bilirubin UDPGT gene was named Gnt-1.
Department of Biology, Shiga University of Medical Science, Japan.
H
H
Sato
Y
Y
Sakai
O
O
Koiwai
T
T
Watanabe
D000818:Animals; D001663:Bilirubin / Q000378:metabolism*; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D014453:Glucuronosyltransferase / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D012150:Polymorphism, Restriction Fragment Length
D014453:Glucuronosyltransferase; D001663:Bilirubin