[Ammonium bituminosulfonate (Ichthyol). Anti-inflammatory effect and inhibition of the 5-lipoxygenase enzyme].
Ammonium bituminosulphonate (Ichthyol) inhibits 5-lipoxygenase activity in human polymorphonuclear neutrophils. The inhibition is dose-dependent and occurs at non-cytotoxic concentrations of the drug. This results in a decreased release of Leukotriene B4 from polymorphonuclear neutrophils. Furthermore, when applied to the ear skin of AB/Bln mice pretreated with croton oil, Ichthyol reduces the inflammatory reaction.
Diezel
W
W
Dermatologische Klinik und Poliklinik Universität Rostock.
Schewe
T
T
Rohde
E
E
Rosenbach
T
T
Czarnetzki
B M
BM
D000818:Animals; D001094:Arachidonate 5-Lipoxygenase / Q000502:physiology; D016718:Arachidonic Acid / Q000378:metabolism; D003436:Croton Oil; D003872:Dermatitis / Q000276:immunology*; D003879:Dermatologic Agents / Q000494:pharmacology*; D007975:Leukotriene B4 / Q000378:metabolism; D016859:Lipoxygenase Inhibitors; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology
D003879:Dermatologic Agents; D016859:Lipoxygenase Inhibitors; D007975:Leukotriene B4; D016718:Arachidonic Acid; D003436:Croton Oil; D001094:Arachidonate 5-Lipoxygenase
Ammoniumbituminosulfonat (Ichthyol). Antientzündliche Wirkung und Hemmung des Enzyms 5-Lipoxygenase.