[Varicella-zoster virus infection after peripheral blood stem cell autografts in children with leukemia or non-Hodgkin's lymphoma].
Thirty-two patients with leukemia or non-Hodgkin's lymphoma (NHL) who underwent high-dose chemotherapy without total body irradiation (TBI) and peripheral blood stem cell autografts (PBSCT) were evaluated for the occurrence of clinically manifested varicella-zoster virus infection (VZV). In a minimum follow-up of 3 mo, there were 14 cases with VZV; 12 patients were treated with intravenous acyclovir and 2 patients received additional intravenous VZV hyperimmune immunoglobulin preparations. History of previous varicella-zoster at some time before PBSCT was the only significant risk factor for the development of VZV. Furthermore, a significant association between VZV and higher disease-free survival rate after PBSCT was proved. Development of minor and reversible VZV is rather common event after high-dose chemotherapy without TBI and PBSCT. VZV appears to be one of the factors which reflects basic physiologic mechanism preventing relapse of leukemias or NHL after PBSCT.
Department of Pediatrics, University of Tokushima.
Y
Y
Okamoto
Y
Y
Takaue
S
S
Saito
A
A
Hirao
T
T
Suzue
T
T
Shimizu
T
T
Abe
J
J
Sato
T
T
Watanabe
Y
Y
Kawano
D000293:Adolescent; D002644:Chickenpox / Q000635:transmission*; D002648:Child; D002675:Child, Preschool; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000601:surgery*; D008228:Lymphoma, Non-Hodgkin / Q000601:surgery*; D008297:Male; D011183:Postoperative Complications; D014182:Transplantation, Autologous