Identification of indolepyruvic acid as an intermediate of rebeccamycin biosynthesis.
Experimental evidence is presented to demonstrate that indolepyruvic acid is an intermediate in the rebeccamycin biosynthetic pathway. [3-14C]Indolepyruvic acid was prepared and efficiently incorporated (8%) into rebeccamycin by Saccharothrix aerocolonigenes.
Lam
K S
KS
Bristol-Myers Squibb Company, Wallingford, CT 06492.
Forenza
S
S
Doyle
T W
TW
Pearce
C J
CJ
D000192:Actinomycetales / Q000378:metabolism*; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D002227:Carbazoles; D007211:Indoles / Q000037:antagonists & inhibitors / Q000378:metabolism*; D014364:Tryptophan / Q000494:pharmacology
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D002227:Carbazoles; D007211:Indoles; C008122:indol-3-yl pyruvic acid; D014364:Tryptophan; C053339:rebeccamycin