Nonlinkage of 16q markers to familial predisposition to Wilms' tumor.
Wilms' tumor (WT), a childhood cancer of the kidney, occurs in both familial and sporadic forms. Chromosome 11 genes have been implicated in the etiology of WT, and mutations in a gene at chromosomal band 11p13, WT1, have been identified in a few WT cases. However, 11p13 has been excluded as the site of the predisposition mutation segregating in several large WT families, which implies the existence of a non-11p familial predisposition gene. Recently, loss of heterozygosity for 16q markers located between chromosomal bands 16q13 and 16q22 has been reported in approximately 20% of sporadic Wilms' tumors. To determine if this region of 16q harbors the non-11p familial WT gene, a genetic linkage study of five WT families was undertaken. Using multipoint analyses, we ruled out genetic linkage of familial WT predisposition to 16q.
Department of Biochemistry and Molecular Biology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
V
V
Huff
A E
AE
Reeve
M
M
Leppert
L C
LC
Strong
E C
EC
Douglass
C F
CF
Geiser
F P
FP
Li
A
A
Meadows
D F
DF
Callen
G
G
Lenoir
D002871:Chromosome Banding; D002885:Chromosomes, Human, Pair 16; D005260:Female; D016162:Genes, Wilms Tumor; D005819:Genetic Markers; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D008126:Lod Score; D008297:Male; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D009396:Wilms Tumor / Q000235:genetics*
D005819:Genetic Markers