[The synthesis of new pyrrolidone derivatives with psychotropic action].
The synthesis of ten new heterocyclic compounds obtained by the addition of pyrrolidone to heterocumulenes and its condensation or of its sodic derivative with acid chlorides is presented. The synthetized pyrolidonic derivatives were subjected to a preliminary study for determining their possible psychotropic action. The pharmacological screening evidenced a significant hypothermisante and neurodynamic-nootropic action of some synthetized compounds.
Universitatea de Medicină şi Farmacie Iaşi.
E
E
Stefănescu
M
M
Petrovanu
I
I
Ciocoiu
M
M
Caproşu
E
E
Bîcu
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects; D011619:Psychotropic Drugs / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D011619:Psychotropic Drugs; D011760:Pyrrolidinones
Sinteza unor noi derivaţi pirolidonici cu acţiune psihotropă.