Further evidence concerning catecholamine metabolism in polycystic ovary syndrome following Gn-RH administration.
The role of catecholamine activity in the GnRH-LH system among cases of polycystic ovary syndrome was investigated by high-performance liquid chromatography using an electrochemical detector. We measured plasma levels of catecholamine metabolites, 3-methoxy-4-hydroxyphenylglycol (MHPG) and 3,4-dihydroxyphenylacetic acid (DOPAC), in relation to LH-RH administration in 23 women with polycystic ovary syndrome. MHPG concentrations were significantly higher in polycystic ovary syndrome patients than in ten control subjects in early follicular phase. The peak values of LH after LH-RH administration were significantly correlated with plasma MHPG concentrations. These data suggest that an excess of norepinephrine is present in polycystic ovary syndrome and that the hypophyseal response to LH-RH administration is correlated with catecholamine, especially norepinephrine activity.
Department of Obstetrics and Gynecology, Shimane Medical University, Izumo, Japan.
K
K
Yoshino
K
K
Takahashi
A
A
Nishigaki
Y
Y
Eda
M
M
Kitao
D015102:3,4-Dihydroxyphenylacetic Acid / Q000097:blood; D000328:Adult; D002395:Catecholamines / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005498:Follicular Phase / Q000502:physiology; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008734:Methoxyhydroxyphenylglycol / Q000097:blood; D009638:Norepinephrine / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000097:blood*
D002395:Catecholamines; D015102:3,4-Dihydroxyphenylacetic Acid; D007987:Gonadotropin-Releasing Hormone; D008734:Methoxyhydroxyphenylglycol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D009638:Norepinephrine