A new depsipeptide antibiotic, citropeptin.
An actinomycete identified as Streptomyces flavidovirens was found to produce a new cyclic hexadepsipeptide antibiotic, designated citropeptin. Citropeptin showed antitumor activity against P388 murine leukemia.
Institute of Applied Microbiology, University of Tokyo, Japan.
Y
Y
Hayakawa
M
M
Nakagawa
Y
Y
Toda
H
H
Seto
D000818:Animals; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification*; D002470:Cell Survival / Q000187:drug effects; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D015394:Molecular Structure; D010455:Peptides; D010456:Peptides, Cyclic / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism; D014407:Tumor Cells, Cultured
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D010455:Peptides; D010456:Peptides, Cyclic; C064644:citropeptin