Role of central ATP-sensitive potassium channels in the hyperthermic effect of morphine in mice.
Morphine (10 mg/kg, SC) in combination with ICV vehicle induced a significant hyperthermic effect at 120 min (peak time) after injection compared to ICV vehicle plus SC saline (control group). Glibenclamide (50 micrograms, ICV), a selective adenosine triphosphate-sensitive potassium (KATP) channel blocker, in combination with SC saline hardly affected the rectal temperature compared to the control group. ICV glibenclamide antagonized the hyperthermia induced by SC morphine in a dose-dependent manner. From these results, we demonstrated that KATP channels play an important role as modulators of the hyperthermic effect of mu agonists.
Narita
M
M
Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
Suzuki
T
T
Misawa
M
M
Nagase
H
H
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005334:Fever / Q000139:chemically induced / Q000503:physiopathology*; D005905:Glyburide / Q000008:administration & dosage / Q000494:pharmacology; D007276:Injections, Intraventricular; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D015221:Potassium Channels / Q000502:physiology*
D015221:Potassium Channels; D009020:Morphine; D000255:Adenosine Triphosphate; D005905:Glyburide