Comparative study of the H2-receptor antagonists cimetidine, ranitidine, famotidine and nizatidine on the rabbit stomach fundus and sigmoid colon.
The H2-receptor antagonists, cimetidine, ranitidine, famotidine and nizatidine, were tested for their effect on the isolated smooth muscle strips from the rabbit stomach fundus and sigmoid colon. These H2-receptor antagonists were found to possess a concentration-dependent contractile effect on the above smooth muscle preparations and the order of potency was: ranitidine = nizatidine > famotidine > cimetidine. In addition, the smooth muscle preparations from the sigmoid colon were significantly more sensitive to the above compounds than the smooth muscle preparations from the stomach fundus.
Department of Pharmacology, Faculty of Veterinary Medicine, Aristotelian University, Thessaloniki, Greece.
G
G
Kounenis
M
M
Koutsoviti-Papadopoulou
A
A
Elezoglou
A
A
Voutsas
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002927:Cimetidine / Q000494:pharmacology; D012809:Colon, Sigmoid / Q000187:drug effects; D015738:Famotidine / Q000494:pharmacology; D005260:Female; D005748:Gastric Fundus / Q000187:drug effects; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D016567:Nizatidine / Q000494:pharmacology; D011817:Rabbits; D011899:Ranitidine / Q000494:pharmacology
D006635:Histamine H2 Antagonists; D015738:Famotidine; D002927:Cimetidine; D011899:Ranitidine; D000109:Acetylcholine; D016567:Nizatidine