N-terminal alkylated derivatives of [D-Pro10]dynorphin A-(1-11) are highly selective for kappa-opioid receptors.
Choi
H
H
Oregon State University, College of Pharmacy, Corvallis 97331.
Murray
T F
TF
DeLander
G E
GE
Caldwell
V
V
Aldrich
J V
JV
D000478:Alkylation; D000595:Amino Acid Sequence; D000818:Animals; D002531:Cerebellum / Q000378:metabolism; D004399:Dynorphins / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D017473:Receptors, Opioid, kappa / Q000378:metabolism*
D010446:Peptide Fragments; D017473:Receptors, Opioid, kappa; D004399:Dynorphins; C044619:dynorphin (1-11), Pro(10)-