Psychotropic and medical drug interactions.
In a number of situations, drugs used to treat psychiatric and physical illnesses are coadministered to patients suffering primarily from a psychiatric illness. Hence, coadministration of medical and psychiatric drugs is not uncommon. With increasing use of multiple drugs, our ability to treat a number of disorders has increased, but simultaneously, the problem of drug interactions has also assumed importance. A number of factors contribute to such drug interactions in psychiatric patients. All these interactions are both pharmacologically and genetically determined. Genetic susceptibility is not practical to determine. It is therefore essential for the physician to employ drug combinations only when necessary, be aware of the known clinically significant interactions, anticipate and watch for them, avoid dangerous combinations, and monitor the patients receiving combination of drugs with vigilance.
Ananth
J
J
University of California, Harbor UCLA Medical Center, Torrance 90509.
Johnson
K
K
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000145:classification / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000145:classification / Q000627:therapeutic use; D000925:Anticoagulants / Q000008:administration & dosage / Q000145:classification / Q000627:therapeutic use; D000927:Anticonvulsants / Q000008:administration & dosage / Q000145:classification / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000145:classification / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000145:classification / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000145:classification / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000145:classification / Q000627:therapeutic use; D004232:Diuretics / Q000008:administration & dosage / Q000145:classification / Q000627:therapeutic use; D004357:Drug Synergism; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000145:classification / Q000627:therapeutic use; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy*; D011600:Psychopharmacology; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D013566:Sympathomimetics / Q000008:administration & dosage / Q000145:classification / Q000627:therapeutic use; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000145:classification / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000925:Anticoagulants; D000927:Anticonvulsants; D000928:Antidepressive Agents; D000959:Antihypertensive Agents; D000970:Antineoplastic Agents; D014150:Antipsychotic Agents; D004232:Diuretics; D007004:Hypoglycemic Agents; D011619:Psychotropic Drugs; D013566:Sympathomimetics; D014665:Vasodilator Agents