Drug interaction between rifampicin, isoniazid and cotrimoxazole in rabbits.
1 The results of cotrimoxazole (CTZ) co-administration (15 mg kg-1 trimethoprim + 40 mg kg-1 sulphamethoxazole) on plasma concentration and various pharmacokinetic parameters of rifampicin (RIF, 24 mg kg-1) and isoniazid (INH, 14 mg kg-1) were studied. 2 In the test group (n = 6), CTZ was administered on the 24th day of antitubercular treatment (ATT) and given for 7 d. 3 At the end of concurrent treatment with CTZ, RIF half-life (t1/2) and plasma concentration were both increased. However, there was no effect on INH half-life and plasma concentration.
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
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Malhi
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Uppal
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Sharma
D000818:Animals; D004347:Drug Interactions; D006207:Half-Life; D007538:Isoniazid / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011817:Rabbits; D012293:Rifampin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage / Q000097:blood*
D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D007538:Isoniazid; D012293:Rifampin