Dengue 2 virus enhancement in asthmatic and non asthmatic individual.
During the 1981 dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) Cuban epidemic, bronchial asthma (BA) was frequently found as a personal or family antecedent in dengue hemorrhagic fever patients. Considering that antibody dependent enhancement (ADE) plays an important role in the etiopathogenic mechanism of DHF/DSS, we decide to study the Dengue 2 virus (D2V) capability of replication in peripheral blood leukocytes (PBL) from asthmatic patients and healthy persons. In 90% of asthmatic patients and 53.8% of control group it was obtained PBL with a significant D2V enhancing activity (X2 p < 0.01). Power enhancement was higher in asthmatic group. This is the first in vitro study relating BA and the dengue 2 virus immuno enhancement. The results obtained support the role of BA as a risk factor for DHF/DSS as already described on epidemiological data.
Departamento de Virología, Instituto de Medicina Tropical Pedro Kouri, Habana, Cuba.
M G
MG
Guzman
G
G
Kouri
M
M
Soler
J
J
Bravo
A
A
Rodríguez de La Vega
S
S
Vazquez
M
M
Mune
D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000276:immunology; D001249:Asthma / Q000097:blood / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D002478:Cells, Cultured; D003462:Cuba / Q000453:epidemiology; D003715:Dengue / Q000150:complications / Q000276:immunology / Q000382:microbiology*; D003716:Dengue Virus / Q000276:immunology / Q000502:physiology*; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000382:microbiology; D008264:Macrophages / Q000502:physiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D014776:Virus Cultivation; D014779:Virus Replication
D000914:Antibodies, Viral