The H2-receptor antagonist era in duodenal ulcer disease.
This paper reviews the remarkable impact of H2-receptor antagonists on duodenal ulcer management. The development and the scientific rationale of these agents are presented, and efficacy and safety aspects in the short- and long-term treatment of duodenal ulcer disease discussed. Attention is focused on the possible role of "acid rebound" in ulcer relapse following the withdrawal of therapy and on the clinical relevance of prolonged suppression of acid secretion in patients on long-term therapy.
Department of Medicine, University of Cape Town, South Africa.
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Marks
D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans
D006635:Histamine H2 Antagonists