Plasma protein C as a marker of hepatocellular damage in alcoholic liver disease.
The synthesis of a number of clotting factors takes place in a hepatocyte. Therefore, measurement of these factors in the blood have proved to be of additional value in the diagnosis and follow-up of liver diseases. In the present study we evaluated protein C level in the plasma of patients with liver cell damage due to chronic alcohol consumption. A decrease in plasma protein C concentration which correlated with clinical performance of the patients was found. Significant correlations between the level of protein C and antithrombin III, one-stage prothrombin time, factors VII and X and some biochemical tests reflecting liver cell damage were also stated. The obtained data indicate that plasma protein C level may constitute a useful marker of hepatocellular disease in alcoholics.
Kłoczko
J
J
Department of Haematology, Medical Academy, Biastok, Poland.
Mian
M
M
Wojtukiewicz
M Z
MZ
Babiuch
L
L
Bielawiec
M
M
Galar
M
M
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers; D001779:Blood Coagulation Factors / Q000032:analysis; D002802:Cholinesterases / Q000097:blood; D005235:Fatty Liver, Alcoholic / Q000097:blood; D006519:Hepatitis, Alcoholic / Q000097:blood; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood; D008108:Liver Diseases, Alcoholic / Q000097:blood* / Q000473:pathology; D008875:Middle Aged; D011486:Protein C / Q000032:analysis*; D011516:Prothrombin / Q000032:analysis; D005723:gamma-Glutamyltransferase / Q000097:blood
D015415:Biomarkers; D001779:Blood Coagulation Factors; D011486:Protein C; D011516:Prothrombin; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D002802:Cholinesterases; D000469:Alkaline Phosphatase