Altered glucose metabolism in adriamycin-induced heart failure.
Spontaneously hypertensive rats received 1 mg/kg of Adriamycin intravenously once a week for up to 12 weeks; their hearts were excised and perfused with buffer containing 5 mM [1-13C]glucose. Histological evidence of Adriamycin cardiotoxicity was evident after 8 and 12 weeks of treatment and was accompanied by a significant decrease in cardiac function. There were only minor changes in the 31P-NMR spectra in hearts following treatment; however, 13C-NMR spectra revealed decreased incorporation of label into the lactate, alanine and glutamate pools in hearts with severe tissue damage compared to hearts from untreated animals.
Chatham
J C
JC
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Hutchins
G M
GM
Glickson
J D
JD
D000409:Alanine / Q000378:metabolism; D000818:Animals; D004317:Doxorubicin / Q000633:toxicity*; D005947:Glucose / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D006321:Heart / Q000187:drug effects*; D006331:Heart Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D051381:Rats; D011918:Rats, Inbred SHR
D005971:Glutamates; D007773:Lactates; D019344:Lactic Acid; D018698:Glutamic Acid; D004317:Doxorubicin; D005947:Glucose; D000409:Alanine