Effects of omeprazole on the number of immunoreactive gastrin- and somatostatin-cells in the rat gastric mucosa.
The effects of omeprazole--an inhibitor of gastric acid secretion--on gastrin (G)- and somatostatin (D)-cell density in the gastric antral mucosa epithelium in rats were examined, following a 5-day treatment. It was found that omeprazole increased the density of G-cells, whereas it decreased the density of D-cells. That effect was probably independent of hypergastrinaemia, since it could not be blocked by a simultaneous treatment with proglumide--a gastrin receptor blocker. It is concluded that the observed phenomenon is a direct result of a lower gastric acidity, as a consequence of omeprazole treatment.
Department of Experimental Endocrinology and Hormone Diagnostics, University School of Medicine, Lódz, Poland.
M
M
Pawlikowski
M
M
Karbownik
A
A
Lewinski
H
H
Pisarek
E
E
Wajs
M
M
Szkudlinski
D000818:Animals; D002452:Cell Count / Q000187:drug effects; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D005755:Gastrins / Q000032:analysis*; D007150:Immunohistochemistry; D008297:Male; D015282:Octreotide / Q000494:pharmacology; D009853:Omeprazole / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011377:Proglumide / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000032:analysis*
D005755:Gastrins; D013004:Somatostatin; D011377:Proglumide; D009853:Omeprazole; D015282:Octreotide