[Mode of action of sulfasalazine in chronic inflammatory enterocolonic diseases].
We have investigated the mode of action of the sulphasalazine in ulcerative colitis and Crohn's ileitis. We point out: a) the activity of sulphasalazine and its derivative, 5-aminosalicylic acid in prostaglandin's metabolites pathway, by inhibition of lipoxygenase; b) a moderate activity on the cell-mediated immunity by weak inhibition of natural killer activity; c) the 5-amino salicylic acid is effective strongly like a radical scavenger.
Delboy
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Service de Médecine Interne, Hôtel-Dieu, Marseille.
D003093:Colitis, Ulcerative / Q000188:drug therapy*; D003424:Crohn Disease / Q000188:drug therapy*; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D007079:Ileitis / Q000188:drug therapy; D007111:Immunity, Cellular / Q000187:drug effects; D066298:In Vitro Techniques; D011453:Prostaglandins / Q000494:pharmacology; D012460:Sulfasalazine / Q000494:pharmacology* / Q000627:therapeutic use
D005609:Free Radicals; D011453:Prostaglandins; D012460:Sulfasalazine
Mode d'action de la sulfasalazine dans les entérocolopathies inflammatoires chroniques.