Delayed suppressive effect of a low dose of caerulein on the grooming behavior induced by the D1-receptor agonist SKF 38393.
Caerulein (CLN, 0.8-80 micrograms/kg, s.c.) was administered to male rats 10 min or 24 hr before the injection of SKF 38393 (3 mg/kg, i.p.). The increased mouth movement and grooming behavior by SKF 38393 were suppressed dose-dependently by CLN 10 min before the SKF 38393. CLN at the dose of 0.8 micrograms/kg, given 24 hr before the SKF 38393, suppressed the grooming behavior by SKF 38393. These findings suggest that a low dose of CLN, but not a high dose, had a delayed suppressive effect on the grooming behavior induced by an excess of D1-activity.
Department of Pharmacology, School of Dentistry, Iwate Medical University, Morioka, Japan.
Y
Y
Masuda
S
S
Murai
H
H
Saito
E
E
Abe
T
T
Itoh
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D002108:Ceruletide / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D015259:Dopamine Agents / Q000494:pharmacology*; D006120:Grooming / Q000187:drug effects*; D008297:Male; D009068:Movement / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000187:drug effects*; D012844:Sincalide / Q000494:pharmacology
D015259:Dopamine Agents; D017447:Receptors, Dopamine D1; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D002108:Ceruletide; D012844:Sincalide