DNA structure, mutations, and human genetic disease.
The etiology of fragile X syndrome, myotonic dystrophy and Kennedy's disease has been attributed to the massive expansion of triplet repeat DNA sequences. This review details the relationships between the structural diversity of DNA, its secondary structure or DNA-directed mutagenesis, and the expansion of triplet repeats.
Sinden
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Institute of Biosciences and Technology, Texas A & M University, Houston.
Wells
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D001483:Base Sequence; D004247:DNA / Q000737:chemistry* / Q000235:genetics*; D017353:Gene Deletion; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D006801:Humans; D008958:Models, Molecular; D009154:Mutation; D009690:Nucleic Acid Conformation; D017354:Point Mutation; D011995:Recombination, Genetic
D004247:DNA