Impairment of some granulocyte functions in Sweet's syndrome.
Chemotaxis, phagocytic and intracellular killing activities of polymorphonuclear leukocytes (PMNL) were investigated in vitro in 7 patients suffering from the acute phase of Sweet's syndrome. A moderate but consistent impairment of neutrophilic chemotactic activity (NCA) was revealed in all patients. Intracellular killing of blastospores of Candida albicans was diminished in 5/7 patients. Phagocytosis and oxidase activities were within normal levels. These results point to an alteration of some PMNL functions in the acute phase of Sweet's syndrome.
Department of Dermatology, University of Erlangen-Nürnberg, Germany.
P
P
von den Driesch
M
M
Simon
R
R
Schlegel Gomez
O P
OP
Hornstein
D002176:Candida albicans; D002634:Chemotaxis, Leukocyte; D003602:Cytotoxicity, Immunologic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000502:physiology*; D010587:Phagocytosis; D016463:Sweet Syndrome / Q000276:immunology / Q000503:physiopathology*