CSF amine metabolites in depression.
The amine metabolites, namely homovanillic acid (HVA) and 5-hydroxy indoleacetic acid (5-HIAA) were measured in cerebrospinal fluid (CSF) of depressives (n = 30) and controls (n = 30). Depressed patients had significantly lower HVA levels than controls. No significant differences were noted between the two groups in 5-HIAA levels. However, the differences between the groups for the CSF HVA/5-HIAA ratio were larger than those for the CSF HVA alone (p less than 0.01 versus p less than 0.025, respectively). HVA levels correlated positively with monoamine oxidase activity and adenosine deaminase activity.
Department of Neurochemistry, National Institute of Mental Health and Neuroscience, Bangalore, India.
P L
PL
Reddy
S
S
Khanna
M N
MN
Subhash
S M
SM
Channabasavanna
B S
BS
Rao
D000328:Adult; D002851:Chromatography, High Pressure Liquid; D003866:Depressive Disorder / Q000134:cerebrospinal fluid*; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008297:Male; D011339:Probenecid
D006897:Hydroxyindoleacetic Acid; D011339:Probenecid; D006719:Homovanillic Acid