[Schizophrenia and immunity].
In schizophrenia, various modifications of the immune system have been reported. A decrease of interleukin-2 production by T lymphocytes and an increase of IL-2 receptors were observed by several authors. Not only cellular but humoral immunity seems to be modified: apart from the viral hypothesis, an auto-immune hypothesis holds that auto-antibodies may play a role in the biology of schizophrenia. Natural auto-antibodies, preexisting any antigenic stimulation, may also be involved, particularly in the response to neuroleptic drugs.
Service hospitalo-universitaire de santé mentale et de thérapeutique, Hôpital Sainte Anne, Paris.
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Galinowski
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Levy-Soussan
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Lôo
D014150:Antipsychotic Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000096:biosynthesis; D001921:Brain / Q000187:drug effects / Q000276:immunology; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis*; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D015375:Receptors, Interleukin-2 / Q000187:drug effects / Q000276:immunology*; D012559:Schizophrenia / Q000188:drug therapy / Q000276:immunology*; D012565:Schizophrenic Psychology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D014150:Antipsychotic Agents; D001323:Autoantibodies; D007376:Interleukin-2; D015375:Receptors, Interleukin-2
Schizophrénie et immunité.