Clearance of purified human liver gamma-glutamyltransferase after intravenous injection in the rat.
The clearance of gamma-glutamyltransferase was studied by injecting the purified human liver enzyme intravenously in the rat. The results show a biphasic clearance, with a rapid initial rate of removal. The initial uptake is more rapid for neuraminidase-treated GT. Liver accounts for the bulk organ uptake and the enzyme is almost exclusively taken up into the parenchymal cells. We suggest that the uptake of circulating GT is receptor mediated, most likely by the galactose receptor of the parenchymal cells.
Institute of Medical Biology, University of Tromso, Norway.
N E
NE
Huseby
G M
GM
Kindberg
M
M
Grøstad
T
T
Berg
D000818:Animals; D006801:Humans; D007275:Injections, Intravenous; D007457:Iodine Radioisotopes; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D008297:Male; D008657:Metabolic Clearance Rate; D009439:Neuraminidase / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000378:metabolism; D014018:Tissue Distribution; D005723:gamma-Glutamyltransferase / Q000008:administration & dosage / Q000493:pharmacokinetics*
D007457:Iodine Radioisotopes; D011956:Receptors, Cell Surface; C039707:galactose receptor; D005723:gamma-Glutamyltransferase; D009439:Neuraminidase