T cells and eosinophils in the pathogenesis of asthma.
Persistent asthma is characterized by chronic inflammation of the bronchial mucosa, where T cells and eosinophils are prominent. This article summarizes the evidence that asthmatic bronchial inflammation is initiated and propagated by cytokines secreted by activated T cells and other cells, and describes how the release of specific cytokines could result in local preferential accumulation and activation of eosinophils.
Dept of Allergy and Clinical Immunology, National Heart and Lung Institute, London, UK.
C J
CJ
Corrigan
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AB
Kay
D001249:Asthma / Q000209:etiology / Q000503:physiopathology*; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D004804:Eosinophils / Q000276:immunology*; D015870:Gene Expression; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000235:genetics; D006801:Humans; D007073:Immunoglobulin E / Q000502:physiology; D007249:Inflammation / Q000503:physiopathology; D009092:Mucous Membrane / Q000503:physiopathology; D012333:RNA, Messenger / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D016207:Cytokines; D012333:RNA, Messenger; D007073:Immunoglobulin E; D016178:Granulocyte-Macrophage Colony-Stimulating Factor