Changes in hepatic lipogenic enzyme activities in voles and mice treated with monosodium aspartate.
Changes in activities of hepatic lipogenic enzymes, ATP citrate lyase and acetyl-CoA carboxylase, were measured in voles and C57BL mice following neonatal administration of monosodium aspartate (MSA). Hepatic lipogenic enzyme activities in voles were considerably lower than those in mice; these low activities were considered to be one of the characteristics of voles as a herbivore. In the MSA-treated voles and mice, the plasma insulin concentrations increased significantly. The MSA-treated mice showed remarkable obesity and increased lipogenic enzyme activities. In the MSA-treated voles, signs of obesity were not observed and hepatic ATP citrate lyase activity increased significantly; acetyl-CoA carboxylase activity did not increase.
Department of Veterinary Biochemistry, Nippon Veterinary and Animal Science University, Tokyo, Japan.
T
T
Arai
Y
Y
Hasegawa
Y
Y
Oki
D001275:ATP Citrate (pro-S)-Lyase / Q000187:drug effects* / Q000378:metabolism; D000103:Acetyl-CoA Carboxylase / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D003411:Arvicolinae / Q000378:metabolism*; D001224:Aspartic Acid / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D007328:Insulin / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000378:metabolism
D001786:Blood Glucose; D007328:Insulin; D001224:Aspartic Acid; D001275:ATP Citrate (pro-S)-Lyase; D000103:Acetyl-CoA Carboxylase