Vaccine strategies against schistosomiasis.
In this review the authors analyze the effector and regulatory mechanisms in the immune response to schistosomiasis. To study these mechanisms two animal models were used, mouse and rat. The mouse totally permissive host like human, show prominent-T cell control in the acquisition of resistance. But other mechanisms like antibody mediated cytotoxicity (ADCC) involving eosinophils and IgG antibodies described in humans, are observed in rats. Also in this animal, it is observed specific IgE antibody high production and blood and tissue eosinophilia. Using the rat model and schistosomula as target, some ADCC features have emerged: the cellular population involved are bone marrow derived inflammatory cell (mononuclear phagocytes, eosinophils and platelets), interacting with IgE through IgE Fc receptors. Immunization has been attempted using the recombinant protein Sm28/GST. Protection has been observed in rodents with significant decrease of parasite fecundity and egg viability affecting the number, size and volume of liver egg granulomas. The association of praziquantel and immunization with Sm28/GST increases the resistance to infection and decreases egg viability. The authors suggest the possibility of the establishment of a future vaccine against Schistosoma mansoni.
Capron
A
A
Centre d'Immunologie et de Biologie Parasitaire, Unité Mixte INSERM U167, CNRS 624, Institut Pasteur, Lille, France.
Dessaint
J P
JP
Capron
M
M
Pierce
R J
RJ
D000818:Animals; D000909:Antibodies, Helminth / Q000276:immunology; D000920:Antibody-Dependent Cell Cytotoxicity; D000947:Antigens, Helminth / Q000276:immunology; D004195:Disease Models, Animal; D004198:Disease Susceptibility / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007132:Immunoglobulin Isotypes / Q000276:immunology; D051379:Mice; D008954:Models, Biological; D011223:Praziquantel / Q000627:therapeutic use; D051381:Rats; D012552:Schistosomiasis / Q000276:immunology / Q000517:prevention & control*; D012555:Schistosomiasis mansoni / Q000276:immunology; D013045:Species Specificity; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014612:Vaccines
D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D007132:Immunoglobulin Isotypes; D014612:Vaccines; D011223:Praziquantel