Effect of elevated serum prolactin concentrations on cytokine production and natural killer cell activity.
In vitro and in vivo studies in rodents and human suggested an immunostimulatory effect of prolactin. The aim of the present study was to determine the impact of chronically elevated serum prolactin concentrations on the immune system in patients with prolactinomas. For this purpose parameters of the humoral and cellular immune system were studied in seven patients with prolactinomas on two occasions (1) when their serum prolactin concentration had been normalized through treatment with dopamine agonists and (2) when their serum prolactin concentration was high. Serum concentrations of immunoglobulines, interleukin 1, 3 and 6, TNF-alpha, interferon-gamma and the soluble interleukin 2 receptor, leukocyte subsets and the natural killer cell activity were found to be within the normal range on both occasions, i.e. at normal and at high serum prolactin concentrations. The assumption could be made that long-lasting elevation of serum prolactin concentration induces adaptive changes when the acute stimulatory effects of prolactin on several parameters of the immune system have subsided.
Clodi
M
M
Department of Medicine II, University of Vienna, Austria.
Svoboda
T
T
Kotzmann
H
H
Deyssig
R
R
Woloszczuk
W
W
Zielinski
C C
CC
Luger
A
A
D000328:Adult; D000368:Aged; D016207:Cytokines / Q000096:biosynthesis* / Q000187:drug effects / Q000276:immunology; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D007375:Interleukin-1 / Q000097:blood; D007377:Interleukin-3 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000276:immunology* / Q000378:metabolism; D011388:Prolactin / Q000097:blood* / Q000276:immunology / Q000378:metabolism; D015175:Prolactinoma / Q000097:blood / Q000276:immunology* / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D016207:Cytokines; D007136:Immunoglobulins; D007375:Interleukin-1; D007377:Interleukin-3; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D011388:Prolactin