Biopharmacological data and high-performance liquid chromatographic analysis of 1,4-benzodiazepines in biological fluids: a review.
A review with 123 references on the analysis of 1,4-benzodiazepines in biological samples using HPLC is presented. Some important physico-chemical and biopharmacological data for the development of analytical methods are collected. Different methods of sample pretreatment, chromatographic conditions and detection systems are discussed.
Departamento de Química Analítica, Facultad de Ciencias, Universidad del Paías Vasco, Bilbao, Spain.
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Berrueta
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Gallo
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Vicente
D014151:Anti-Anxiety Agents / Q000032:analysis* / Q000097:blood / Q000378:metabolism / Q000652:urine; D001569:Benzodiazepines; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003975:Diazepam / Q000032:analysis; D005479:Flurazepam / Q000032:analysis; D008140:Lorazepam / Q000031:analogs & derivatives / Q000032:analysis; D010084:Oxidation-Reduction; D014229:Triazolam / Q000032:analysis
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D014229:Triazolam; C023842:lormetazepam; D005479:Flurazepam; D008140:Lorazepam; D003975:Diazepam