Dexmedetomidine attenuates sympathoadrenal responses to tracheal intubation and reduces the need for thiopentone and peroperative fentanyl.
The effects of the new, highly selective alpha 2-adrenergic agonist, dexmedetomidine, were studied in a randomized, placebo-controlled, double-blind trial in 24 ASA I patients. Dexmedetomidine 0.6 micrograms kg-1 or saline was given i.v. 10 min before induction of anaesthesia. The required dose of thiopentone was significantly (P less than 0.001) smaller in the dexmedetomidine group (mean 4.4 (sd 0.9) mg kg-1) than in the control group (6.9 (1.6) mg kg-1), and the drug attenuated the cardiovascular responses to laryngoscopy and tracheal intubation. The concentration of noradrenaline in mixed venous plasma was smaller in the dexmedetomidine group during all phases of induction (P less than 0.01). During surgery, fentanyl was required in a dose of 0.5 (0.6) mg kg-1 and 2.8 (2.6) mg kg-1 in the dexmedetomidine and control groups, respectively (P less than 0.001). During 2 h postoperative follow-up, oxycodone 0.06 (0.06) mg kg-1 and 0.16 (0.1) mg kg-1 (P less than 0.05) was given to the two groups respectively.
Department of Anaesthesia, University Central Hospital, Helsinki, Finland.
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Scheinin
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Lindgren
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Randell
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Scheinin
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Scheinin
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000328:Adult; D000762:Anesthesia Recovery Period; D000768:Anesthesia, General; D004311:Double-Blind Method; D004837:Epinephrine / Q000097:blood; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D007442:Intubation, Intratracheal; D008297:Male; D020926:Medetomidine; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D011229:Preanesthetic Medication; D013874:Thiopental / Q000008:administration & dosage
D000316:Adrenergic alpha-Agonists; D007093:Imidazoles; D013874:Thiopental; D020926:Medetomidine; D005283:Fentanyl; D009638:Norepinephrine; D004837:Epinephrine