Effect of atrial natriuretic peptide on apomorphine-induced stereotyped cage-climbing behavior in mice.
In previous experiments, it was observed that rat atrial natriuretic peptide-(1-28) (ANP-(1-28)) participated in fear-induced learning and memory processes via dopaminergic and cholinergic mediation. Since cage-climbing behavior is described as a simple test for studying dopaminergic activity in the central nervous system, a systemic study was carried out with ANP-(1-28) in order to confirm or to exclude the possible involvement of dopamine in the ANP-induced action in the brain. The present study demonstrate that ANP-(1-28) facilitated cage-climbing behavior in mice in a dose-dependent manner. When combined with apomorphine, the peptide potentiated the effect of the dopamine agonist. The effect of ANP-(1-28) in combination with apomorphine could be antagonized by a selected dose of haloperidol. These data suggest that ANP might be regarded as a dopamine agonist-modulating agent and that a dopaminergic mechanism is a possible mode of action of ANP in the fear-induced learning studied earlier.
Institute of Pathophysiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
A
A
Bidzseranova
J
J
Gueron
G
G
Tóth
B
B
Penke
G
G
Telegdy
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D004298:Dopamine / Q000502:physiology; D015259:Dopamine Agents / Q000494:pharmacology; D018492:Dopamine Antagonists; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
D015259:Dopamine Agents; D018492:Dopamine Antagonists; D009320:Atrial Natriuretic Factor; D006220:Haloperidol; D001058:Apomorphine; D004298:Dopamine