HI-6 pharmacokinetics in rabbits after intravenous and intramuscular administration.
The pharmacokinetics of HI-6 ((4-carboxamidopyridinium (1) methyl)-(2'-hydroxyiminomethyl-pyridinium (1') methyl) ether dichloride) have been studied in rabbits receiving an intramuscular (50 micrograms kg-1) or intravenous (12.5 micrograms kg-1) dose. The plasma concentration-time profile for the intramuscular dose (n = 8) fits a one-compartment open model with first-order absorption and elimination. The absorption half-life was 2 min and maximum concentration (51 micrograms mL-1) was reached in 9 min. The pharmacokinetics for the intravenous dose (n = 8) was described by a two-compartment open model with first-order distribution and elimination. The apparent volume of distribution was 0.1 L kg-1. Half-lives of distribution and elimination were 5 and 38 min, respectively. The results indicate HI-6 is rapidly absorbed, distributed and eliminated in rabbits receiving an intramuscular dose.
United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland 21010-54245.
B J
BJ
Lukey
C L
CL
Woodard
C R
CR
Clark
M P
MP
McCluskey
D000818:Animals; D000931:Antidotes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002801:Cholinesterase Reactivators / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004195:Disease Models, Animal; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007306:Insecticides / Q000506:poisoning; D008297:Male; D009943:Organophosphorus Compounds; D010091:Oximes; D011726:Pyridinium Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011817:Rabbits
D000931:Antidotes; D002801:Cholinesterase Reactivators; D007306:Insecticides; D009943:Organophosphorus Compounds; D010091:Oximes; D011726:Pyridinium Compounds; C022870:asoxime chloride