Effect of cacao husk extract on human immunodeficiency virus infection.
A sodium hydroxide extract from cacao husk inhibited the cytopathic effect of human immunodeficiency virus type 1 (HIV-1) against HTLV-1-transformed T-cell lines MT-2 and MT-4. It also inhibited syncytium formation between HIV-infected and uninfected lymphoblastoid T-cell line, MOLT-4. The anti-HIV activity was concentrated by membrane filter fractionation to a fraction with molecular weight of 100-300 KDa. Anti-HIV activity of the extract was attributable to interference with the virus adsorption, rather than to inhibition of the virus replication after adsorption.
Unten
S
S
AIDS Research Center, National Institute of Health, Tokyo, Japan.
Ushijima
H
H
Shimizu
H
H
Tsuchie
H
H
Kitamura
T
T
Moritome
N
N
Sakagami
H
H
D002099:Cacao; D002460:Cell Line; D002461:Cell Line, Transformed; D005591:Chemical Fractionation; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D015726:Giant Cells / Q000187:drug effects; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013601:T-Lymphocytes / Q000382:microbiology*; D014779:Virus Replication / Q000187:drug effects
D010936:Plant Extracts