Graft engineering: the evolution of hematopoietic transplantation.
In vivo therapeutic manipulation as well as ex vivo grafting are important strategies for bone marrow manipulation and transplantation. This review article discusses the early techniques for marrow processing and manipulation as a background for discussing later graft engineering protocols, as well as preclinical and experimental protocols designed to modify transplantation biology at the multidisciplinary level. The direction of future trials in graft transplantation is also discussed.
Graft Engineering Laboratory, Johns Hopkins Oncology Center, Baltimore, MD 21205.
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D001698:Biomedical Engineering / Q000379:methods*; D016026:Bone Marrow Transplantation / Q000379:methods; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D013048:Specimen Handling / Q000379:methods