Structure-activity relationship of new 10-13 membered oxygen-nitrogen heterocyclic systems containing two aromatic rings.
The synthesis and biological activity of new 10-13 membered oxygen-nitrogen heterocyclic systems condensed with two aromatic rings is reported. The structure-activity relationship of these new compounds in X-ray investigation has been studied. Pharmacological investigations have shown that the compounds exhibit weak neuroleptic activity.
Department of Technology and Chemistry of Drugs, Medical Akademy of Lódź, Poland.
K
K
Walczyński
R
R
Glinka
A
A
Stepień
T
T
Olszak
P
P
Sabatino
D000818:Animals; D014150:Antipsychotic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D065127:Dopamine D2 Receptor Antagonists; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000378:metabolism; D013329:Structure-Activity Relationship; D014961:X-Ray Diffraction
D014150:Antipsychotic Agents; D065127:Dopamine D2 Receptor Antagonists; D006571:Heterocyclic Compounds; D017447:Receptors, Dopamine D1; D011976:Receptors, Muscarinic