Bullatencin, 4-deoxyasimicin, and the uvariamicins: additional bioactive Annonaceous acetogenins from Annona bullata Rich. (Annonaceae).
Additional bioactive Annonaceous acetogenins have been isolated from the EtOH extract of the bark of Annona bullata Rich. by bioactivity-directed fractionation using lethality to brine shrimp. These acetogenins include bullatencin, a new single tetrahydrofuran acetogenin having a double bond in the hydrocarbon chain; 4-deoxyasimicin, a new adjacent bis-tetrahydrofuran acetogenin; and the uvariamicins, an isomeric mixture of four single tetrahydrofuran acetogenins showed selective cytotoxicities for certain human solid tumor cell lines comparable to or better than adriamycin.
Department of Medical Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907.
Y H
YH
Hui
K V
KV
Wood
J L
JL
McLaughlin
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D033364:Decapoda; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification*; D014407:Tumor Cells, Cultured / Q000187:drug effects
C087001:4-deoxyasimicin; D000972:Antineoplastic Agents, Phytogenic; D005663:Furans; D007783:Lactones; C087002:bullatencin