Keratin expression in chemically induced mouse lung adenomas.
Chemically induced mouse lung tumors exhibit distinctive growth patterns, characterized by an alveolar or solid appearance, a papillary appearance, or a combination of the two. Lung tumors induced in strain A/J mice by either benzo(a)pyrene (BP) or by N-nitrosoethylurea (ENU) were examined for expression of low- and high-molecular-weight cytokeratins. Simple cytokeratins (low molecular weight) were found in all epithelial cells of the normal mouse lung and in all tumor types, whereas higher-molecular-weight cytokeratins were found only in normal bronchiolar cells and in papillary tumor cells. These data lend support to the hypothesis that chemically induced papillary lung tumors in strain A/J mice are derived from bronchiolar Clara cells.
Gunning
W T
WT
Department of Pathology, Medical College of Ohio, Toledo 43699-0008.
Goldblatt
P J
PJ
Stoner
G D
GD
D000236:Adenoma / Q000139:chemically induced / Q000737:chemistry* / Q000648:ultrastructure; D000818:Animals; D001580:Benzopyrenes; D005038:Ethylnitrosourea; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis*; D008175:Lung Neoplasms / Q000139:chemically induced / Q000737:chemistry* / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008854:Microscopy, Electron
D001580:Benzopyrenes; D007633:Keratins; D005038:Ethylnitrosourea