[The effect of chronic combined exposure to nickel and lead on the enzymatic indices in body uptake with the drinking water].
A toxicological experiment on white male rats was carried out for one year. They received simultaneously per os nickel in doses 0.005 mg/kg and lead in doses 0.0025 mg/kg, equivalent respectively to the recommended by CMEA norms for nickel and hygienic norm for lead in drinking waters, as well as nickel and lead in doses 0.015 and 0.01 mg/kg, 0.015 and 0.1 mg/kg surpassing 3 and 4 times and 30 and 40 times the above mentioned norms or only nickel in doses 0.015 mg/kg, after which their effect on some enzyme indices was studied. Tests were made on: free sulfhydryl groups in blood serum, heart and liver; catalase activity of blood; cholinesterase activity and creatinphosphatase in blood serum; cytochromoxidase activity in liver and heart. It is established that in combined per os effect of nickel and lead in doses respectively 0.15 and 0.1 mg/kg and 0.015 and 0.01 mg/kg, as well as during independent effect of nickel with doses 0.015 mg/kg, occur disorders in the tissue breathing and oxyreduction processes. Nickel and lead in doses, equivalent to the hygienic norms, lead to no changes according to all studied indices.
Ts
Ts
Vodichenska
D000818:Animals; D002374:Catalase / Q000097:blood / Q000187:drug effects*; D002802:Cholinesterases / Q000097:blood / Q000187:drug effects*; D003402:Creatine Kinase / Q000097:blood / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D003576:Electron Transport Complex IV / Q000032:analysis / Q000187:drug effects*; D007854:Lead / Q000633:toxicity*; D008297:Male; D051379:Mice; D009532:Nickel / Q000633:toxicity*; D013438:Sulfhydryl Compounds / Q000032:analysis; D013997:Time Factors; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D013438:Sulfhydryl Compounds; D014874:Water Pollutants, Chemical; D007854:Lead; D009532:Nickel; D002374:Catalase; D003576:Electron Transport Complex IV; D003402:Creatine Kinase; D002802:Cholinesterases
Vliianie na khronichnoto kombinirano vŭzdeĭstvie s nikel i olovo vŭrkhu niakoi enzimni pokazateli pri postŭpvaneto im v organizm s piteīnite vodi.