Neurochemical mechanisms of memory control.
Modulation of memory trace retrieval in emotiogenic brain structures, cortex and brainstem reticular formation by postsynaptic noradrenergic and dopaminergic drugs was found. At the initial stage of latent inhibition-a most significant mechanism of information selection-memory trace retrieval is retarded in all structures and in the cortex and the zona incerta later on. A haloperidol model of latent inhibition was obtained. Most important role of dopaminergic system in latent inhibition was shown. Inhibition of the GABA-benzodiazepine-ionophore complex by the blockade of GABA-receptors induced by bicuculline, the chloride channels by picrotoxin, the benzodiazepine receptors by flumazenil (R015-1788) and R015-3505 facilitates the memory trace retrieval damaged by amnesic agent. The dopaminergic activation enhances the dominant state and developes conditions for switching on the interferential GABA-ergic inhibition.
Institute of Physiology, Siberian Branch of the Academy of Medical Sciences, Novosibirsk, Russia.
R Y
RY
Ilyutchenok
L V
LV
Loskutova
A L
AL
Finkelberg
N I
NI
Dubrovina
D000647:Amnesia / Q000503:physiopathology; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000502:physiology; D002415:Cats; D004298:Dopamine / Q000502:physiology; D005071:Evoked Potentials; D005442:Flumazenil / Q000494:pharmacology; D058787:GABA-A Receptor Antagonists; D008297:Male; D008568:Memory / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D018377:Neurotransmitter Agents / Q000502:physiology*; D009638:Norepinephrine / Q000502:physiology; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000502:physiology
D001640:Bicuculline; D004298:Dopamine; D005442:Flumazenil; D058787:GABA-A Receptor Antagonists; D018377:Neurotransmitter Agents; D009638:Norepinephrine; D010852:Picrotoxin; D011963:Receptors, GABA-A