Isolation and synthesis of a new bio-antimutagen, petasiphenol, from scapes of Petasites japonicum.
A new bio-antimutagen, petasiphenol [3-(3,4-dihydroxyphenyl)-2-oxopropyl caffeate] (1) was isolated from scapes of Petasites japonicum (AD50 = 95 micrograms/ml against UV-induced mutagenic E. coli WP2 B/r Trp-. Petasiphenol (1) and its isomer (2) were synthesized. The activity of 1 was observed in the presence of soybean oil (glyceride), although the isomer (2) did not show any activity in doses up to 300 micrograms/ml.
Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University, Nagano, Japan.
R
R
Iriye
K
K
Furukawa
R
R
Nishida
C
C
Kim
H
H
Fukami
D016587:Antimutagenic Agents / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000494:pharmacology; D001709:Biotechnology; D002109:Caffeic Acids / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D007536:Isomerism; D009154:Mutation / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*
D016587:Antimutagenic Agents; D002109:Caffeic Acids; C079021:petasiphenol