Mapping rat brain structures activated during ethanol withdrawal: role of glutamate and NMDA receptors.
Brain structures activated during ethanol withdrawal have been mapped by visualizing c-fos mRNA expression. The regional distribution of c-fos mRNA in brain during ethanol withdrawal can be mimicked by acute injection of N-methyl-D-aspartic acid (NMDA) and is stereospecifically blocked by the NMDA receptor antagonist, MK-801. The findings reveal that the dentate gyrus and piriform cortex are selectively activated during ethanol withdrawal and suggest that this may be mediated by glutamate activation of NMDA receptors.
Morgan
P F
PF
Laboratory of Clinical Studies, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892.
Nadi
N S
NS
Karanian
J
J
Linnoila
M
M
D000818:Animals; D001921:Brain / Q000502:physiology; D001923:Brain Chemistry / Q000502:physiology; D001931:Brain Mapping; D016291:Dizocilpine Maleate / Q000494:pharmacology; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D005971:Glutamates / Q000502:physiology*; D018698:Glutamic Acid; D008297:Male; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology*; D015290:Second Messenger Systems / Q000187:drug effects / Q000502:physiology; D013237:Stereoisomerism; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*
D005971:Glutamates; D016760:Proto-Oncogene Proteins c-fos; D012333:RNA, Messenger; D016194:Receptors, N-Methyl-D-Aspartate; D000431:Ethanol; D018698:Glutamic Acid; D016291:Dizocilpine Maleate