Possible mechanisms of activation of soluble guanylate cyclase by organic nitrates.
Various possible mechanisms for the activation of soluble guanylate cyclase by the organic nitrates are discussed. It is suggested that the mechanisms in intact blood vessels and in blood vessel homogenates are probably different.
Yeates
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Research Laboratories; Pfizer/Mack Ltd., Illertissen, Fed. Rep. of Germany.
D001808:Blood Vessels / Q000187:drug effects; D004789:Enzyme Activation / Q000187:drug effects; D006162:Guanylate Cyclase / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009566:Nitrates / Q000494:pharmacology*; D009569:Nitric Oxide / Q000494:pharmacology
D009566:Nitrates; D009569:Nitric Oxide; D006162:Guanylate Cyclase