Protein metal-binding sites.
Metal ions have a role in a variety of important functions in proteins including protein folding, assembly, stability, conformational change, and catalysis. The presence or absence of a given metal ion is crucial to the conformation or activity of over one third of all proteins. Recent developments have been made in the understanding and design of metal-binding sites in proteins, an important and rapidly advancing area of protein engineering.
Tainer
J A
JA
Department of Molecular Biology, Scripps Research Institute, La Jolla, CA 92037.
Roberts
V A
VA
Getzoff
E D
ED
D001665:Binding Sites; D003198:Computer Simulation; D008670:Metals / Q000378:metabolism*; D011487:Protein Conformation; D015202:Protein Engineering; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*
D008670:Metals; D011506:Proteins