Comparison of cyclosporine and FK506 effects on glutathione levels in rat cochlea, brain, liver and kidney.
Cyclosporine treatment (50 mg/kg/day, p.o.) caused increases in rat renal reduced glutathione (GSH) levels of 205 and 673%, respectively, after 5 and 10 days. No changes were seen in liver GSH with either dose of cyclosporine. FK506 (2.5 mg/kg/day, p.o., for 7 days) caused an approximately 200% increase in kidney GSH, and an approximately 250% increase in hepatic GSH levels. Oxidized glutathione (GSSG) was never more than 1-2% of the level of the reduced form in any tissue from control animals. Small increases in the ratios of oxidized to reduced glutathione were seen in livers and kidneys from both cyclosporine- and FK506-treated animals. No changes in GSH or GSSG levels were seen in brains or cochleas from any animal.
Department of Psychiatry, Dartmouth Medical School, Hanover, NH 03755.
R D
RD
Edkins
L P
LP
Rybak
D W
DW
Hoffman
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003051:Cochlea / Q000187:drug effects / Q000378:metabolism; D016572:Cyclosporine / Q000494:pharmacology* / Q000633:toxicity; D005978:Glutathione / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D016559:Tacrolimus / Q000494:pharmacology* / Q000633:toxicity
D016572:Cyclosporine; D005978:Glutathione; D016559:Tacrolimus