Low density lipoprotein composition and oxidizability in coronary disease--apparent favourable effect of beta blockers.
The oxidative modification of LDL in vivo may have an important role in atherogenesis. To determine whether LDL fatty acid, anti-oxidant composition and sensitivity to oxidation in vitro is different in subjects with established atherosclerosis we compared 20 men with angiogram proven coronary disease with 25 controls without clinical evidence of arterial disease. LDL-cholesterol, total triglycerides and LDL fatty acid composition did not differ significantly between the groups. LDL oxidation lag time and oxidation rate in coronary patients (132 min, 0.02 absorbance units/min) and controls (140, 0.017) were not significantly different. However coronary disease subjects taking beta-blockers had evidence for reduced LDL oxidizability (lag time 148 +/- 7 min; oxidation rate 0.017 +/- 0.002 abs units/min) compared with those not on beta-blockers (lag time 114 +/- 7 min, rate 0.025 +/- 0.003, P < 0.005). LDL beta-carotene was significantly lower in coronary patients (0.92 mumol/mmol LDL cholesterol; controls 1.58; P = 0.001). LDL alpha-tocopherol appeared lower in coronary patients (2.8 mumol/mmol LDL cholesterol; controls 3.3; P = 0.056) and was significantly lower in smokers (2.56; non-smokers 3.24; P = 0.04). LDL oxidation rate was negatively correlated with LDL alpha-tocopherol (r = -0.51, P = 0.005).(ABSTRACT TRUNCATED AT 250 WORDS)
Department of Medicine, University of Western Australia, Perth.
K D
KD
Croft
S B
SB
Dimmitt
C
C
Moulton
L J
LJ
Beilin
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D002338:Carotenoids / Q000032:analysis; D003324:Coronary Artery Disease / Q000097:blood* / Q000188:drug therapy; D005227:Fatty Acids / Q000032:analysis; D006801:Humans; D008055:Lipids / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D014810:Vitamin E / Q000032:analysis; D019207:beta Carotene
D000319:Adrenergic beta-Antagonists; D005227:Fatty Acids; D008055:Lipids; D008077:Lipoproteins, LDL; D019207:beta Carotene; D014810:Vitamin E; D002338:Carotenoids