[Histochemical picture of kidneys from pregnant female rats subjected to the action of vibramycin].
Female rats were given intragastrically, by means of a probe, Vibramycine in suspension, in a dose 4 mg/kg body weight, in different stages of pregnancy. On kidney sections there were performed: H+E staining, PAS reaction, histochemical determination of enzymes activity: alkaline phosphatase, ATP-ase, SDH and LDH. In non-pregnant females receiving the drug there was observed an intensification of alkaline phosphatase activity in brush border of main tubules of the kidney and a slight broadening of the light of the tubules. In pregnant females receiving the drug, most clearly in the second half of pregnancy a slight intensification of the activity of the examined enzymes was observed.
Katedra i Zakład Histologii i Embriologii z Pracownia Cytologii Doświadczalnej, Akademia Medyczna w Lublinie.
J
J
Romanowska
E
E
Kifer-Wysocka
W
W
Matysiak
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D004318:Doxycycline / Q000494:pharmacology*; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism
D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D000469:Alkaline Phosphatase; D000251:Adenosine Triphosphatases; D004318:Doxycycline
Obraz histochemiczny nerki ciezarnych szczurzyc poddanych działaniu wibramycyny.