[The effect of the new nonsteroidal anti-inflammatory agent glucamine on oxidative phosphorylation processes].
A study was made of the action of the nonsteroidal antiinflammatory agent glucamin on the processes of oxidation and phosphorylation (OP) in isolated mitochondria of the liver. It has been established that glucamin does not exhibit the properties of a separator in the explored concentrations (10(-2)-10(-7) M). Unlike the standard drug voltaren that separates OP processes, it slightly enhances interaction of liver mitochondria which oxidize NAD-dependent substrates. The effect of voltaren is dose-dependent, being pronounced to a greater measure when succinate is applied as a substrate of mitochondria oxidation.
Iakovleva
L V
LV
Drogovoz
S M
SM
Romanova
V E
VE
Chernobaeva
G N
GN
Luk'ianova
L D
LD
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004008:Diclofenac / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005944:Glucosamine / Q000494:pharmacology*; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D066298:In Vitro Techniques; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D051381:Rats; D013386:Succinates / Q000378:metabolism; D019802:Succinic Acid
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005971:Glutamates; D013386:Succinates; D004008:Diclofenac; D018698:Glutamic Acid; D019802:Succinic Acid; D005944:Glucosamine
Vliianie novogo nesteroidnogo protivovospalitel'nogo sredstva gliukamina na protsessy okislitel'nogo fosforilirovaniia.