Improved neurological outcome following early anatomical correction of transposition of the great arteries.
The incidence of neurological residuals following anatomical correction of transposition of the great arteries (d-TGA) has not been described so far. Clinical examination, EEG recordings, and computed tomography (CT) scans were carried out in a consecutive series of 38 children with d-TGA surviving anatomic corrective surgery. The patients were classified into one of three groups according to the type of operation: 15 patients after two-stage approach (TSA) (Stage 1: pulmonary artery banding+aortopulmonary shunt; Stage 2: anatomic correction); 12 patients with primary anatomic correction within the first 2 weeks of life (early switch, ES); 11 patients with primary anatomic correction later in infancy (later switch, LS). In 26 patients (68%) we found no abnormalities on neurologic examination, CT scan, or EEG. Four patients suffered from spastic hemiplegia, 3 of these had cortical brain damage visible on CT scan, and 3 had focal epilepsy as well. In 2 otherwise clinical normal patients cortical infarction could be seen on a CT scan. Thus, in 5 cases (13% of 38 patients) cerebral infarcts were diagnosed by CT scan. The cortical vascular infarction was seen in 4 patients after TSA and in 1 after LS. In 6 patients we found other neurological abnormalities. Early anatomic correction in patients with d-TGA reduces the risk of cortical vascular infarction.
Department of Pediatrics and Neuroradiology, University Hospital Hamburg, Germany.
N
N
Veelken
L
L
Grävinghoff
E W
EW
Keck
H J
HJ
Freitag
D002561:Cerebrovascular Disorders / Q000175:diagnosis / Q000453:epidemiology*; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000175:diagnosis / Q000453:epidemiology*; D004569:Electroencephalography; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D009422:Nervous System Diseases / Q000175:diagnosis / Q000453:epidemiology*; D009460:Neurologic Examination; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014188:Transposition of Great Vessels / Q000601:surgery*; D016896:Treatment Outcome