[Reduction of atherogenesis in an arterialized venous graft by using an external sleeve].
The parietal thickening of a vein under hemodynamical conditions in the arterial system can be reduced when supporting the vein with a rigid external sleeve. To assess the role of thickness reduction in atherogenesis of an arterialized vein graft, a 4 mm thick external sleeve was implemented around the proximal half of a carotid-carotid vein graft in 16 New Zealand rabbits. Eleven rabbits were submitted to a hypercholesterolemic diet (HC group), while five others were submitted to a normal cholesterol diet (NC group). After eight weeks, a statistically significant difference in thickness was observed between free and sleeved segments, in the NC group with 105 +/- 9 microns versus 65 +/- 6 microns (p < 10.0001) respectively as well as in the HC group with 180 +/- 37 microns versus 99 +/- 35 microns (p < 10.0001) respectively. Studying the extent of soudanophilic lesions showed a statistically significant difference according to the use or not of an external sleeve where average extent is 68 +/- 17% in free segments versus 31 +/- 26% (p < 10.0001) is sleeved segments. The reduction in vein overfullness using an external constrictive sleeve prevents structural parietal changes in the vein and allows reducing atherogenesis of the arterialized vein graft.
Hôpital Beaujon, service de Chirurgie vasculaire et thoracique, Clichy.
J
J
Batellier
A
A
Tedgui
D000818:Animals; D001161:Arteriosclerosis / Q000517:prevention & control*; D002339:Carotid Arteries / Q000601:surgery; D002985:Clinical Protocols; D004730:Endothelium, Vascular / Q000473:pathology*; D006937:Hypercholesterolemia / Q000150:complications; D011817:Rabbits; D014182:Transplantation, Autologous; D014680:Veins / Q000637:transplantation*
Réduction de l'athérogenèse d'un greffon veineux artérialisé par un manchon externe.