Metal-binding sites in proteins.
A dramatic increase in the number of solved metalloprotein structures and recent breakthroughs in structural analysis have provided a sufficiently detailed understanding of the structural chemistry of some metal-binding sites to allow successful design. As a result, metal-binding site design is now one of the most powerful and promising approaches for influencing protein folding, assembly, stability and catalysis.
Department of Molecular Biology, Scripps Research Institute, La Jolla, California 92037.
J A
JA
Tainer
V A
VA
Roberts
E D
ED
Getzoff
D000595:Amino Acid Sequence; D001665:Binding Sites; D008667:Metalloproteins / Q000737:chemistry*; D008670:Metals / Q000737:chemistry; D008958:Models, Molecular; D008969:Molecular Sequence Data; D015202:Protein Engineering
D008667:Metalloproteins; D008670:Metals