Aneuploidy in nonneoplastic and benign melanocytic and breast lesions determined by DNA flow cytometry.
A total of ten of 60 nonneoplastic lesions and eight of 76 benign neoplasms of skin and breast showed an aneuploid peak in DNA flow cytometry profiles obtained from archival paraffin blocks. This confirms previous similar scattered reports and emphasizes that caution needs to be exercised in interpreting aneuploidy in DNA flow cytometry to mean preneoplasia, neoplasia, or malignancy.
Department of Pathology, University of Western Ontario, London, Canada.
J V
JV
Frei
V J
VJ
Martinez
D000782:Aneuploidy; D001941:Breast Diseases / Q000235:genetics* / Q000473:pathology; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology; D004247:DNA / Q000378:metabolism; D005434:Flow Cytometry; D006801:Humans; D008544:Melanocytes / Q000473:pathology*; D012871:Skin Diseases / Q000235:genetics* / Q000473:pathology; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology
D004247:DNA