[Effects of amiridin and tacrine, drugs effective in Alzheimer's disease, on synaptosomal uptake of neuromediators].
The study of the drugs effective in the treatment of cognitive deficits and memory loss associated with senile dementia of the Alzheimer's type--tacrine and amiridin, acetylcholinesterase inhibitor physostigmine and nootrop piracetam on uptake of 3H-serotonin (3H-5-HT), 3H-adrenaline (3H-AD), 3H-noradrenaline (3H-HA), 2H-dopamine (3H-DA), 3H-gamma-aminobutyric acid (3H-GABA), 3H-glutamic acid (3H-GLU), 3H-aspartic acid (3H-ASP) and 3H-glycine (3H-GLI) showed that tacrine and amiridin (5 x 10(-5) M) statistically significantly (P less than 0.05) inhibited the uptake of 3H-DA and 3H-5-HT. Physostigmine at concentration 5 x 10(-4) M statistically significantly (P less than 0.05) inhibited uptake of 3H-5-HT only. Piracetam at concentration range 1-5 x 10(-3) M had no effect on uptake of all investigated neurotransmitters. The above finding suggest that the uptake of neurotransmitter in nerve terminals is not the main target of amiridin and tacrine.
Iu V
IuV
Burov
T D
TD
Baĭmanov
N I
NI
Maĭsov
D000544:Alzheimer Disease / Q000188:drug therapy*; D000634:Aminoquinolines / Q000494:pharmacology*; D000818:Animals; D002800:Cholinesterase Inhibitors; D004298:Dopamine / Q000378:metabolism; D004837:Epinephrine / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D010830:Physostigmine / Q000494:pharmacology; D010889:Piracetam / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*; D013619:Tacrine / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000634:Aminoquinolines; D002800:Cholinesterase Inhibitors; D018377:Neurotransmitter Agents; D011619:Psychotropic Drugs; D012701:Serotonin; D013619:Tacrine; D005680:gamma-Aminobutyric Acid; D010830:Physostigmine; C049860:amiridine; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine; D010889:Piracetam
Vliianie amiridina i takrina--preparatov, éffektivnykh pri bolezni Al'tsgeĭmera, na sinaptosomal'nyĭ zakhvat neĭromediatorov.