Viral phenotype and immune response in primary human immunodeficiency virus type 1 infection.
Nineteen individuals were studied for virologic and immunologic events during primary human immunodeficiency virus type 1 (HIV-1) infection. In 16 individuals only non-syncytium-inducing (NSI) isolates were detected; syncytium-inducing (SI) isolates were obtained from 3. Studies of transmitter-recipient pairs indicated that both NSI variants and SI variants were transmitted and that SI variants may be suppressed in the recipient. CD4+ T cells remained in the normal range in 15 of 16 individuals with NSI isolates but rapidly declined in all 3 individuals with SI variants, 1 of whom was treated with zidovudine. The most marked increase in CD8+ T cells and activated CD8+ T cells was observed in individuals with the most pronounced clinical signs of acute HIV-1 infection. Activated CD8+ T cells were only transiently elevated in individuals with SI variants, suggesting that an impaired cellular anti-HIV-1 immune response plays a role in the rapid progression to AIDS.
Central Laboratory of the Netherlands Red Cross Blood Transfusion Service (Laboratory of Experimental and Clinical Immunology), Department of Internal Medicine, Amsterdam.
M T
MT
Roos
J M
JM
Lange
R E
RE
de Goede
R A
RA
Coutinho
P T
PT
Schellekens
F
F
Miedema
M
M
Tersmette
D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D005260:Female; D015726:Giant Cells; D015483:HIV Antibodies / Q000096:biosynthesis; D015658:HIV Infections / Q000150:complications / Q000276:immunology / Q000382:microbiology*; D015497:HIV-1 / Q000145:classification / Q000276:immunology / Q000502:physiology*; D006801:Humans; D008231:Lymphopenia / Q000150:complications*; D008297:Male; D010641:Phenotype; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D015483:HIV Antibodies