Diazepam and atropine as premedicants: no discrimination by monoamine metabolite and catecholamine measurements in cerebrospinal fluid and plasma.
The relationships between self-reported assessments of the quality of the preoperative night's sleep, preoperative anxiety, and several biochemical and physiological indicators of stress reaction were investigated in pregnant women at term receiving no premedication (n = 15), a placebo tablet (n = 15), diazepam 5 mg p.o. (n = 15), or atropine 0.01 mg/kg i.m. (n = 15), in connection with spinal analgesia for elective caesarean section. In the patients receiving no premedication, the subjective estimate of the quality of the preoperative night's sleep was negatively associated with concentrations of noradrenaline (NA) and its metabolite, 3-methoxy-4-hydroxyphenylglycol (MHPG) in CSF, and with plasma adrenaline. The anxiolytic effect of diazepam was reflected as significantly lower plasma levels of another metabolite of NA, 3,4-dihydroxyphenylglycol (DHPG). Placebo and diazepam, and to a lesser extent atropine, confounded the statistical relationships between the clinical and biochemical responses found in the patients with no premedication. On the whole, the biochemical monoamine measurements were of little use in determining the clinical effects of different kinds of premedicants.
Department of Anaesthesiology, University of Turku, Finland.
J
J
Kanto
M
M
Scheinin
D015102:3,4-Dihydroxyphenylacetic Acid / Q000097:blood / Q000134:cerebrospinal fluid; D000328:Adult; D015360:Analgesia, Epidural; D001007:Anxiety / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D001285:Atropine; D002585:Cesarean Section / Q000523:psychology*; D003975:Diazepam; D004298:Dopamine / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D004837:Epinephrine / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006719:Homovanillic Acid / Q000097:blood / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000097:blood / Q000134:cerebrospinal fluid; D008734:Methoxyhydroxyphenylglycol / Q000031:analogs & derivatives / Q000097:blood / Q000134:cerebrospinal fluid; D009638:Norepinephrine / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D010919:Placebos; D011229:Preanesthetic Medication; D011247:Pregnancy; D012701:Serotonin / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D012890:Sleep / Q000502:physiology
D010919:Placebos; D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D001285:Atropine; D003975:Diazepam; C010117:3,4-dihydroxyphenylglycol; D004298:Dopamine; D009638:Norepinephrine; D006719:Homovanillic Acid; D004837:Epinephrine