Can virostatic chemotherapy and/or adoptive allogeneic immunotherapy eradicate in vivo Friend's virus infection?
While none of the three drugs which exert an in vitro anti-HIV effect, neither AZT nor the other two, acriflavine and elliptinium, which we have shown to be more efficient than AZT, is able to eradicate Friend's virus in vivo, the combination of the 3 drugs at much smaller doses than when given alone seems able to eradicate it in almost 30% of the infected animals. This possible eradicating effect of virostatics in combination is compared with the results we had previously obtained with lymphocytes of virus-immunized allogeneic donors.
G
G
Mathé
M
M
Trabaud
E
E
Chenu
C
C
Bourut
D000818:Animals; D004338:Drug Combinations; D004358:Drug Therapy; D015497:HIV-1 / Q000187:drug effects*; D007167:Immunotherapy; D007942:Leukemia, Experimental / Q000628:therapy*; D051379:Mice; D015215:Zidovudine / Q000494:pharmacology
D004338:Drug Combinations; D015215:Zidovudine