Cerebrospinal fluid concentrations of neuropeptide Y in depressed patients and in controls.
Concentrations of Neuropeptide Y-like (NPY-LI) immunoreactivity in cerebrospinal fluid (CSF) were measured in a group of depressed patients (n = 24) and compared with that of control subjects (n = 12). CSF-NPY-LI was significantly reduced in the group of non-endogenously depressed patients when classified according to Newcastle Rating Scale for Depression--1971 (N-II). No significant correlation was found in the control or depressed groups between lumbar concentrations of NPY-LI and a number of other neurotransmitters.
Sct. Hans Hospital, Dept. P & Research Institute of Biological Psychiatry, Roskilde, Denmark.
A
A
Gjerris
E
E
Widerlöv
L
L
Werdelin
R
R
Ekman
D000328:Adult; D000368:Aged; D003866:Depressive Disorder / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009478:Neuropeptide Y / Q000134:cerebrospinal fluid*; D018377:Neurotransmitter Agents / Q000134:cerebrospinal fluid; D011569:Psychiatric Status Rating Scales; D011863:Radioimmunoassay
D009478:Neuropeptide Y; D018377:Neurotransmitter Agents