Mapping rat brain structures activated during ethanol withdrawal: role of glutamate and NMDA receptors.
Brain structures activated during ethanol withdrawal have been mapped by visualizing c-fos mRNA expression. The regional distribution of c-fos mRNA in brain during ethanol withdrawal can be mimicked by acute injection of N-methyl-D-aspartic acid (NMDA) and is stereospecifically blocked by the NMDA receptor antagonist, MK-801. The findings reveal that the dentate gyrus and piriform cortex are selectively activated during ethanol withdrawal and suggest that this may be mediated by glutamate activation of NMDA receptors.
Laboratory of Clinical Studies, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892.
P F
PF
Morgan
N S
NS
Nadi
J
J
Karanian
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M
Linnoila
D000818:Animals; D001921:Brain / Q000502:physiology; D001923:Brain Chemistry / Q000502:physiology; D001931:Brain Mapping; D016291:Dizocilpine Maleate / Q000494:pharmacology; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D005971:Glutamates / Q000502:physiology*; D018698:Glutamic Acid; D008297:Male; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology*; D015290:Second Messenger Systems / Q000187:drug effects / Q000502:physiology; D013237:Stereoisomerism; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*
D005971:Glutamates; D016760:Proto-Oncogene Proteins c-fos; D012333:RNA, Messenger; D016194:Receptors, N-Methyl-D-Aspartate; D000431:Ethanol; D018698:Glutamic Acid; D016291:Dizocilpine Maleate