Zidovudine therapy in combination with intravenous immunoglobulin in HIV infected children.
There is little published data on concomitant use of zidovudine and intravenous immunoglobulin (IV IgG). In this paper we review our experience of four HIV-1 infected children treated with zidovudine for periods of 19-33 months (mean 26.5 months) subsequent to starting IV IgG for period of 18-20 months (mean 19 months). In these children the only clear benefit we found was in one child who had developed HIV encephalopathy which resolved after starting zidovudine. The respective roles of zidovudine and intravenous immunoglobulin in HIV-1 infected children need to be clarified in larger comparative trials.
Croft
N
N
Regional Infectious Diseases Unit, City Hospital, Edinburgh.
Yap
P L
PL
Mok
J Y
JY
Hague
R A
RA
Burns
S M
SM
D015496:CD4-Positive T-Lymphocytes; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy* / Q000401:mortality; D015497:HIV-1; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use*; D007223:Infant; D007958:Leukocyte Count; D015996:Survival Rate; D016896:Treatment Outcome; D015215:Zidovudine / Q000008:administration & dosage / Q000627:therapeutic use*
D016756:Immunoglobulins, Intravenous; D015215:Zidovudine