Crystal structure of nevirapine, a non-nucleoside inhibitor of HIV-1 reverse transcriptase, and computational alignment with a structurally diverse inhibitor.
Mui
P W
PW
Department of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut 06877.
Jacober
S P
SP
Hargrave
K D
KD
Adams
J
J
D001381:Azepines / Q000737:chemistry* / Q000494:pharmacology; D001569:Benzodiazepines / Q000737:chemistry / Q000494:pharmacology; D001665:Binding Sites; D003461:Crystallography; D015497:HIV-1 / Q000187:drug effects / Q000201:enzymology; D007093:Imidazoles / Q000737:chemistry / Q000494:pharmacology; D008958:Models, Molecular; D008968:Molecular Conformation; D019829:Nevirapine; D011725:Pyridines / Q000737:chemistry* / Q000494:pharmacology; D018894:Reverse Transcriptase Inhibitors; D014961:X-Ray Diffraction
D001381:Azepines; D007093:Imidazoles; D011725:Pyridines; D018894:Reverse Transcriptase Inhibitors; D001569:Benzodiazepines; C067413:R-82913; D019829:Nevirapine