Effects of picroliv, the active principle of Picrorhiza kurroa, on biochemical changes in rat liver poisoned by Amanita phalloides.
The efficacy of Picroliv, a standardized iridoid glycoside fraction of Picrorhiza kurroa, was studied against the Amanita phalloides-induced biochemical changes in rat liver. A phalloides (50 mg.kg-1) caused significant increases in the activities of hepatic 5'-nucleotidase, gamma-glutamyl transpeptidase, acid ribonuclease, and succinate dehydrogenase, but a decrease in glucose-6-phosphatase. The level of cytochrome P-450 in microsomal fraction and content of glycogen in liver showed significant depletions. Picroliv (25 mg.kg-1.d-1 x 10 d) provided significant restorations of all the biochemical changes poisoned by A phalloides except cytochrome P-450 and glycogen. These results demonstrated the protective effect of Picroliv against A phalloides-induced hepatotoxicity in rats.
Dwivedi
Y
Y
ICMR Centre for Advanced Pharmacological Research on Traditional Remedies, Central Drug Research Institute, Lucknow, India.
Rastogi
R
R
Garg
N K
NK
Dhawan
B N
BN
D000545:Amanita; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications / Q000201:enzymology*; D002934:Cinnamates / Q000494:pharmacology*; D006027:Glycosides / Q000494:pharmacology*; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D009145:Mushroom Poisoning / Q000150:complications / Q000201:enzymology*; D010088:Oxidoreductases / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014641:Vanillic Acid / Q000494:pharmacology*; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D002934:Cinnamates; D006027:Glycosides; D008112:Liver Glycogen; C057463:kutkin; D010088:Oxidoreductases; D005723:gamma-Glutamyltransferase; D010744:Phosphoric Monoester Hydrolases; D014641:Vanillic Acid