On the regulation of beta 2 integrins.
The complex functions played by beta 2 integrins in mediating a large variety of adhesive interactions of leukocytes are highly regulated. This regulation results in transient adaptations/associations, permitting physical and functional recycling of these receptors during chemotaxis, phagocytosis and target-cell killing. The structural definition of these adaptations will lead not only to a better understanding of how these receptors are regulated in leukocytes but also shed valuable light on how these integrins integrate diverse extracellular signals into spatially and temporaly coordinated cellular responses.
Leukocyte Biology and Inflammation Program, Massachusetts General Hospital, Boston.
M A
MA
Arnaout
M
M
Michishita
C P
CP
Sharma
D000595:Amino Acid Sequence; D015703:Antigens, CD / Q000096:biosynthesis; D018845:CD11 Antigens; D018821:CD18 Antigens; D003034:Coated Pits, Cell-Membrane / Q000378:metabolism; D003593:Cytoplasm; D003598:Cytoskeletal Proteins / Q000378:metabolism; D004705:Endocytosis; D016023:Integrins / Q000096:biosynthesis* / Q000737:chemistry / Q000502:physiology; D007962:Leukocytes / Q000737:chemistry / Q000502:physiology*; D008024:Ligands; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D015398:Signal Transduction
D015703:Antigens, CD; D018845:CD11 Antigens; D018821:CD18 Antigens; D003598:Cytoskeletal Proteins; D016023:Integrins; D008024:Ligands