A young female case of polyarteritis nodosa strongly suspected by typical angiographic findings which improved rapidly after prednisolone and cyclophosphamide therapy.
A 16-year-old girl was admitted with the complaints of headache, chest pain, low abdominal pain and left hemi-numbness. Her blood pressure was high and plasma renin activity and aldosterone levels were elevated. Renal angiography revealed vascular stenoses and microaneurysms although the renal artery and its main branches were not involved. Polyarteritis nodosa (PN) was strongly suspected and oral prednisolone and intravenous pulse therapy of cyclophosphamide were started. The second renal angiography which was performed 11 days after the therapy was started, showed marked improvement of vascular lesions. This is a case which suggests that the angiographic findings of PN can improve very rapidly with therapy.
First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
H
H
Yamada
M
M
Oka
S
S
Mori
T
T
Takahashi
S
S
Kuwata
C
C
Aizawa
G
G
Toda
K
K
Kurokawa
D000293:Adolescent; D000783:Aneurysm / Q000000981:diagnostic imaging / Q000188:drug therapy; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D010488:Polyarteritis Nodosa / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D011859:Radiography; D012077:Renal Artery / Q000000981:diagnostic imaging
D003520:Cyclophosphamide; D011239:Prednisolone