Digoxin-specific Fab fragments impair renal function in the rabbit.
A 2 mg kg-1 intravenous bolus dose of digoxin-specific Fab fragments produced a 28% reduction in creatinine clearance in rabbits after 24 h. Urine output was reduced, while plasma and urinary creatinine concentrations were unaffected and increased, respectively. By 5 days the creatinine clearance had returned to normal. The fractional excretion of Na+ was nearly halved, indicating that the tubular reabsorption of Na+ increased to compensate for the reduced glomerular filtration rate, suggesting that tubular (as opposed to glomerular) function was not impaired.
Department of Pharmacology and Clinical Pharmacology, University of Dundee, Ninewells Hospital and Medical School, UK.
M P
MP
Timsina
D S
DS
Hewick
D000465:Algorithms; D000818:Animals; D003404:Creatinine / Q000097:blood / Q000652:urine; D004077:Digoxin / Q000276:immunology*; D005260:Female; D007140:Immunoglobulin Fab Fragments / Q000633:toxicity*; D007128:Immunoglobulin Fragments / Q000633:toxicity*; D007275:Injections, Intravenous; D011817:Rabbits; D012079:Renal Circulation / Q000187:drug effects*; D012964:Sodium / Q000097:blood / Q000652:urine
D007140:Immunoglobulin Fab Fragments; D007128:Immunoglobulin Fragments; D004077:Digoxin; D012964:Sodium; D003404:Creatinine