Abnormality of background EEG determined by the entropy of power spectra in epileptic patients.
Relationships between epileptiform discharges and background activity were examined by power spectral entropy (PSE), measuring a degree of EEG irregularity. The EEGs were recorded from 10 electrodes placed at F3, F4, C3, C4, T3, T4, P3, P4, O1 and O2 in 11 epileptic patients with widespread lateralized spike and wave complexes (SWCs). Bipolar records were also made from the antero-posterior derivations. The locations of the maximum PSE coincided with those of the maximum amplitude of SWC in most of the patients. Bipolar derivations with the maximum PSE always included the locations with the maximum PSE obtained from a linked ears reference. Pearson's correlation coefficient between PSE and SWC amplitude was 0.62 +/- 0.14 (mean +/- S.D.) in 11 patients, thus indicating that the scalp distribution of PSE was closely related to that of the amplitude of SWC. These findings suggest that the background EEG is disorganized in or near the epileptogenic focus. A focal background abnormality can therefore be estimated by PSE.
Inouye
T
T
Department of Neuropsychiatry, Osaka University Medical School, Japan.
Shinosaki
K
K
Sakamoto
H
H
Toi
S
S
Ukai
S
S
Iyama
A
A
Katsuda
Y
Y
Hirano
M
M
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000503:physiopathology*; D002648:Child; D004569:Electroencephalography / Q000379:methods; D004827:Epilepsy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male