8-Methoxy- and p-dimethoxy-1-aminoethylhetero-tetralins: synthesis and DA, 5-HT receptors affinities.
Two series of compounds, 8-methoxy- and p-dimethoxy derivatives of 1-aminoethylhetero-tetralins, I, were evaluated for D-2, 5-HT1 and 5-HT2 receptors affinity. No significant serotoninergic affinity was observed, whereas p-dimethoxy-derivatives 7b e 11b showed a moderate D-2 affinity.
Dipartimento Farmaco-Chimico, Università di Bari, Italy.
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R
Perrone
F
F
Berardi
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S
Ferorelli
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V
Tortorella
M D
MD
Lograno
E
E
Daniele
S
S
Govoni
D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D015259:Dopamine Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D066298:In Vitro Techniques; D051381:Rats; D017448:Receptors, Dopamine D2 / Q000187:drug effects; D017366:Serotonin Receptor Agonists / Q000138:chemical synthesis* / Q000494:pharmacology; D013764:Tetrahydronaphthalenes / Q000138:chemical synthesis* / Q000494:pharmacology
D015259:Dopamine Agents; D017448:Receptors, Dopamine D2; D017366:Serotonin Receptor Agonists; D013764:Tetrahydronaphthalenes