Evidence for hormonal inhibition of exocrine pancreatic function by somatostatin 28 in humans.
Somatostatin 28 (S-28), originating in gastrointestinal cells, is secreted into the circulation and increases in humans after ingestion of a mixed meal. To evaluate the possibility that the increased levels of S-28 post cibum might modulate the release of enzymes and bicarbonate from the exocrine pancreas, S-28 was infused intravenously into healthy volunteers to levels seen after food intake. During S-28 infusion, the output of lipase, trypsin, amylase, and bicarbonate stimulated by either exogenous cholecystokinin octapeptide or endogenous signals from intraduodenal administration of tryptophan or a mixture of amino acids was significantly reduced. It is concluded that S-28 released from the gut during food intake modulates pancreatic exocrine function in humans.
Division of Gastroenterology, University Hospital, Basel, Switzerland.
P
P
Hildebrand
J W
JW
Ensinck
K
K
Gyr
S
S
Mossi
J
J
Leuppi
C
C
Eggenberger
C
C
Beglinger
D000328:Adult; D000596:Amino Acids / Q000494:pharmacology; D002766:Cholecystokinin / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004386:Duodenum; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009994:Osmolar Concentration; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D010477:Perfusion; D013004:Somatostatin / Q000097:blood / Q000494:pharmacology*; D053561:Somatostatin-28; D014364:Tryptophan / Q000494:pharmacology
D000596:Amino Acids; D013004:Somatostatin; D053561:Somatostatin-28; D014364:Tryptophan; D002766:Cholecystokinin