Difenacoum poisoning as a cause of haematuria.
A man presented with frank haematuria and a grossly prolonged prothrombin time. He was later found to have taken an overdose of difenacoum--a 'superwarfarin' rodenticide. The diagnosis was confirmed by a serum concentration of difenacoum of 0.6 micrograms ml-1. Overdosage with superwarfarins is discussed and the need for prolonged treatment with vitamin K1 highlighted.
Ealing General Hospital, Southall, Middlesex, UK.
G P
GP
Butcher
M J
MJ
Shearer
A D
AD
MacNicoll
M J
MJ
Kelly
P W
PW
Ind
D015110:4-Hydroxycoumarins / Q000097:blood / Q000506:poisoning*; D000328:Adult; D062787:Drug Overdose; D006417:Hematuria / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D008297:Male; D011517:Prothrombin Time; D012378:Rodenticides / Q000097:blood / Q000506:poisoning*; D014812:Vitamin K / Q000627:therapeutic use
D015110:4-Hydroxycoumarins; D012378:Rodenticides; D014812:Vitamin K; C012903:difenacoum