Chromatographic resolution of the chiral isomers of several beta-blockers over cellulose tris(3,5-dimethylphenylcarbamate) chiral stationary phase.
The optical resolution of seven beta-blockers which have in common the N-isopropyl-3-aryloxy-2-hydroxypropylamine moiety was carried out by HPLC using the cellulose tris(3,5-dimethylphenylcarbamate) chiral stationary phase to quantitatively characterize the enantioselectivity of these compounds. The capacity factors and separation factors at different column temperature were determined with some qualitative trends derived. A compensation effect was observed for these compounds where there exists an approximately linear relationship between the enantiomeric differences in enthalpic and entropic energies.
Department of Chemical Engineering, National University of Singapore.
C B
CB
Ching
B G
BG
Lim
E J
EJ
Lee
S C
SC
Ng
D000319:Adrenergic beta-Antagonists / Q000032:analysis*; D002482:Cellulose; D002851:Chromatography, High Pressure Liquid; D013237:Stereoisomerism; D013696:Temperature
D000319:Adrenergic beta-Antagonists; D002482:Cellulose