Viral-associated haemophagocytosis with parvovirus-B19-related pancytopenia.
Viral-associated haemophagocyte syndrome in response to infection with human parvovirus B19 was seen in 2 patients with hereditary spherocytosis. Depressed reticulocyte response during acute parvovirus infection is a known cause of hypoproliferative crises in patients with reduced erythrocyte lifespan; the observation of parvovirus-associated haemophagocytosis could account for the pancytopenia that may accompany human parvovirus B19 infection.
Department of Haematology, Monklands District General Hospital, Airdrie, UK.
K
K
Muir
W T
WT
Todd
W H
WH
Watson
E
E
Fitzsimons
D000328:Adult; D001803:Blood Transfusion; D001856:Bone Marrow Examination; D002648:Child; D004279:DNA, Viral / Q000097:blood; D016731:Erythema Infectiosum / Q000097:blood / Q000150:complications* / Q000473:pathology; D015616:Histiocytosis, Non-Langerhans-Cell / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D010198:Pancytopenia / Q000097:blood / Q000209:etiology* / Q000628:therapy; D013103:Spherocytosis, Hereditary / Q000150:complications*
D004279:DNA, Viral; D007075:Immunoglobulin M