Ranitidine, cimetidine, famotidine have no effect on post-prandial absorption of ethanol 0.8 g/kg taken after an evening meal.
Forty-seven healthy male subjects were studied twice using a randomized, placebo-controlled design. Each subject took an 8-day course of two of the following four regimens; 300 mg ranitidine, 800 mg cimetidine, 40 mg famotidine or placebo (identical either to 300 mg ranitidine or 800 mg cimetidine). The systemic bioavailability of ethanol (integrated 6-h plasma ethanol concentration, peak plasma ethanol concentration, and the time to peak plasma ethanol concentration) was measured after the oral ingestion of 0.8 g of ethanol per kg body weight, given one hour after an evening meal on Day 8 of each regimen. There was no significant difference of integrated 6-h plasma ethanol concentration, peak ethanol concentration, or time to reach peak ethanol concentration after dosing with either ranitidine, cimetidine or famotidine or placebo.
Fraser
A G
AG
University Department of Medicine, Royal Free Hospital School of Medicine, London, UK.
Hudson
M
M
Sawyerr
A M
AM
Smith
M
M
Rosalki
S B
SB
Pounder
R E
RE
D000042:Absorption / Q000187:drug effects; D000328:Adult; D001682:Biological Availability; D002927:Cimetidine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004347:Drug Interactions; D004435:Eating; D000431:Ethanol / Q000097:blood / Q000493:pharmacokinetics*; D015738:Famotidine / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011899:Ranitidine / Q000494:pharmacology
D006635:Histamine H2 Antagonists; D000431:Ethanol; D015738:Famotidine; D002927:Cimetidine; D011899:Ranitidine