Urinary glycylprolyl dipeptidyl aminopeptidase (GP-DAP) in insulin-dependent diabetic patients.
Urinary glycylprolyl dipeptidyl aminopeptidase (GP-DAP) concentrations were determined in 36 insulin-dependent diabetic children aged 4-18 years with a duration of diabetes ranging from 1 month to 14 years. Abnormal urinary GP-DAP concentrations were found in 19 of the 36 patients. Twelve of 27 patients without microalbuminuria also had increased urinary concentrations of GP-DAP. There was a significant correlation between urinary GP-DAP and plasma fructosamine (r = 0.52, p < 0.001). Our data suggest that urinary GP-DAP may be used as a marker for diabetic nephropathy. However, there is also a possibility that increased urinary GP-DAP concentrations are functionally related to poor metabolic control. Longitudinal studies are needed to establish the clinical usefulness of urinary GP-DAP.
Nukada
O
O
Department of Pediatrics, Okayama University, School of Medicine, Japan.
Kobayashi
M
M
Moriwake
T
T
Kanzaki
S
S
Himei
H
H
Yoda
T
T
Seino
Y
Y
D000293:Adolescent; D000367:Age Factors; D000419:Albuminuria / Q000453:epidemiology / Q000209:etiology / Q000652:urine; D015415:Biomarkers / Q000652:urine; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications / Q000652:urine*; D003928:Diabetic Nephropathies / Q000453:epidemiology / Q000209:etiology / Q000652:urine; D018819:Dipeptidyl Peptidase 4; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000652:urine*; D005069:Evaluation Studies as Topic; D019270:Fructosamine; D006595:Hexosamines / Q000097:blood; D006785:Hospitals, University; D006801:Humans; D007564:Japan / Q000453:epidemiology; D015995:Prevalence; D012044:Regression Analysis
D015415:Biomarkers; D006595:Hexosamines; D019270:Fructosamine; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D018819:Dipeptidyl Peptidase 4