The persistence of sister-chromatid exchange frequencies in men occupationally exposed to vinyl chloride monomer.
The persistence of sister-chromatid exchange frequencies in a population occupationally exposed to the well known chemical mutagen vinyl chloride monomer was studied. It was shown that increased values of sister-chromatid exchange frequencies were still present in the lymphocytes of workers who had not been exposed for 8-120 days and retired persons for 5-10 years after exposure. The possible ability of vinyl chloride monomer alkylating metabolites to cause long-lasting damage of the DNA molecule is discussed.
Fucić
A
A
Institute for Medical Research and Occupational Health, University of Zagreb, Croatia, Yugoslavia.
Garaj-Vrhovac
V
V
Dimitrović
B
B
Skara
M
M
D000328:Adult; D002617:Chemical Industry; D004247:DNA / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009153:Mutagens / Q000009:adverse effects*; D016273:Occupational Exposure; D010969:Plastics; D012854:Sister Chromatid Exchange / Q000187:drug effects; D013997:Time Factors; D014752:Vinyl Chloride / Q000009:adverse effects*
D009153:Mutagens; D010969:Plastics; D004247:DNA; D014752:Vinyl Chloride