[Effect of propranolol on electrophysiologic features of the heart in patients with hyperthyroidism].
The effect of increasing doses of intravenously administered propranolol on electrophysiological features of heart was studied in 17 patients with untreated hyperthyroidism by using the transesophageal stimulation method. A positive and dose-dependent effect of propranolol on the studied parameters was found with the normalization of the majority of disturbances taking place after the administration of 6 mg of propranolol. This dose was safe and well tolerated by the patients. The sensitivity of the auriculo-ventricular junction to propranolol was less pronounced during the stimulated rhythm than during the sinus rhythm.
Gasińska
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I Klinika Chorób Wewnetrznych Slaskiej AM, Katowicach.
Prochaczek
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F
Izbicka
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D000328:Adult; D004305:Dose-Response Relationship, Drug; D017548:Echocardiography, Transesophageal; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000627:therapeutic use*
D011433:Propranolol
Wpływ propranololu na właściwości elektrofizjologiczne serca u chorych z nadczynnościa tarczycy.