Composite tumor of the main bile duct producing several regulatory peptides.
Herein we describe what is, to our knowledge, the first reported case of a composite tumor of the main bile duct with epiploon metastases. Glucagon, pancreatic polypeptide, and somatostatin-immunoreactive cells were demonstrated in these metastases, but not serotonin, gastrin, or insulin-immunoreactive cells. The clinical significance of the neuroendocrine cells in the present case is discussed.
Department of Medicine III, University Hospital of Lisbon, Portugal.
J
J
Ducla-Soares
M
M
Ferreira
C
C
Campos
G P
GP
Gomes
A
A
Ginestal-Cruz
H L
HL
Silva
M D
MD
Gonçalves
D000328:Adult; D001650:Bile Duct Neoplasms / Q000737:chemistry* / Q000473:pathology; D003135:Common Bile Duct; D005260:Female; D005934:Glucagon / Q000032:analysis; D006801:Humans; D009077:Mucins / Q000032:analysis; D009373:Neoplasms, Germ Cell and Embryonal / Q000737:chemistry* / Q000473:pathology / Q000556:secondary; D009852:Omentum; D010191:Pancreatic Polypeptide / Q000032:analysis; D010534:Peritoneal Neoplasms / Q000556:secondary; D013004:Somatostatin / Q000032:analysis
D009077:Mucins; D013004:Somatostatin; D010191:Pancreatic Polypeptide; D005934:Glucagon