[Lipid peroxidation and erythrocyte membrane function in congenital heart defects in relation to the use of beta-adrenoblockers].
Oxygen tension in the blood and tissues, lipid peroxidation (LP) intensity (content of malonic blood dialdehyde and activity of superoxide dismutase in erythrocytes), spectrum of fatty acids and phospholipid composition of erythrocytic membranes, their passive K(+) permeability, total ATP content in erythrocytes, some other metabolic indices were investigated in 24 patients with blue type congenital heart disease. It was shown that these patients showed a reduced oxygen tension in the blood and tissues, LP intensification, changes of the lipid phase of erythrocytic membranes, disorders of their permeability, decrease of intraerythrocytic ATP reserves. Beta-adrenoblocking agents (obsidan, anaprilin were used in 10 patients. Reported are clinico-metabolic findings indicating a favourable effects of these drugs on LP processes, lipid spectrum of erythrocytic membranes, their permeability and bioenergy reactions.
Minkov
I P
IP
D000319:Adrenergic beta-Antagonists / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002463:Cell Membrane Permeability / Q000187:drug effects; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D006330:Heart Defects, Congenital / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000097:blood
D000319:Adrenergic beta-Antagonists; D008055:Lipids
Perekisnoe okislenie i sostoianie éritrotsitarnykh membran pri vrozhdennykh porokakh serdtsa v sviazi s primeneniem nekotorykh beta-adrenoblokatorov.