Effect of organophosphate pesticides on glutaminase synthetase activity in rat brain.
Of the organophosphate pesticides studied, dichlorvos inhibited significantly both, phosphate-activated glutaminase and alpha-keto acid-activated glutaminase, while monocorotophos inhibited moderately alpha-keto acid activated glutaminase in rat brain. Phosphamidon inhibited glutamine synthetase activity negligibly.
Indian Institute of Chemical Biology, Calcutta, India.
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D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D005974:Glutamate-Ammonia Ligase / Q000187:drug effects / Q000378:metabolism*; D005972:Glutaminase / Q000187:drug effects / Q000378:metabolism*; D007306:Insecticides / Q000494:pharmacology*; D008297:Male; D009943:Organophosphorus Compounds; D051381:Rats
D007306:Insecticides; D009943:Organophosphorus Compounds; D005972:Glutaminase; D005974:Glutamate-Ammonia Ligase