Renin gene restriction fragment length polymorphisms in a Japanese family with a high incidence of essential hypertension.
1. Human renin gene restriction fragment length polymorphisms (RFLP) were compared in a Japanese family which has a high incidence of essential hypertension. 2. RFLP of human renin gene were observed in three restriction enzymes, Mbo I, Bgl I and Hind III; 1.4 kb and 1.0 kb [Mbo I], 5.0 kb and 9.0 kb [Bgl I] and 9.0 and 6.2 kb [Hind III]. 3. Plasma renin activity was not associated with blood pressure. 4. Renin gene RFLP were not cosegregated with essential hypertension in this Japanese family.
2nd Department of Internal Medicine, Ehime University School of Medicine, Japan.
T
T
Okura
Y
Y
Kitami
R
R
Wakamiya
T
T
Iwata
K
K
Hiwada
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015139:Blotting, Southern; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes; D005819:Genetic Markers; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000235:genetics*; D007564:Japan; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D012083:Renin / Q000097:blood / Q000235:genetics*
D005819:Genetic Markers; D004247:DNA; D004262:DNA Restriction Enzymes; D012083:Renin