Similar effects of nifedipine and hydralazine on anaesthesia and hypermotility induced by pentobarbitone in mice.
Nifedipine, a dihydropyridine calcium channel blocker, and hydralazine, a non-calcium channel antagonist vasodilatator, enhanced pentobarbitone-induced sleeping time and reversed locomotor hyperactivity induced by a subhypnotic dose of the barbiturate in mice. The similarity of the behavioural effects, exerted by nifedipine and hydralazine, suggest that haemodynamic factors may play an important role in the interaction of calcium channel antagonists with barbiturates.
Istituto di Psicobiologia e Psicofarmacologia, CNR, Roma, Italy.
M
M
Sansone
F
F
Pavone
M
M
Battaglia
W
W
Daniel
J
J
Vetulani
D000758:Anesthesia; D000818:Animals; D004347:Drug Interactions; D006439:Hemodynamics / Q000187:drug effects; D006830:Hydralazine / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D009543:Nifedipine / Q000494:pharmacology*; D010424:Pentobarbital / Q000493:pharmacokinetics / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects
D006830:Hydralazine; D010424:Pentobarbital; D009543:Nifedipine