Induction of thermotolerance by chemical agents in enucleate erythrocytes.
Erythrocytes treated with various chemical agents for 1 h at 37 degrees C showed resistance to a subsequent 1 h heat treatment at 53 degrees C. Maximal thermotolerance was observed 6 h after 3 mM DNP and 0.03 mM disulfiram treatment and 4 h after diamide exposure at 0.3 mM. Our results suggest that chemically induced thermotolerance to heat treatment in erythrocytes was similar to heat-induced thermotolerance.
Chair of Biophysics, University of Lódź, Poland.
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Jóźwiak
D019297:2,4-Dinitrophenol; D000064:Acclimatization / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001151:Arsenic / Q000494:pharmacology; D018053:Arsenites; D003958:Diamide / Q000494:pharmacology; D004140:Dinitrophenols / Q000494:pharmacology*; D004221:Disulfiram / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects / Q000502:physiology*; D006358:Hot Temperature; D066298:In Vitro Techniques; D017670:Sodium Compounds; D013439:Sulfhydryl Reagents / Q000494:pharmacology*; D013552:Swine
D018053:Arsenites; D004140:Dinitrophenols; D017670:Sodium Compounds; D013439:Sulfhydryl Reagents; D003958:Diamide; C017947:sodium arsenite; D001151:Arsenic; D019297:2,4-Dinitrophenol; D004221:Disulfiram