[Acral vasospasm in Crohn's disease].
55 patients with Crohn's disease and 55 sex- and age-matched healthy controls were studied by nailfold capillary microscopy for evidence of microcirculatory abnormalities. Digital capillary blood flow measurements in combination with a local cooling test were assessed by videocapillaroscopy using the flying-sport technique. We found a blood flow stop with cold exposure in 44 of the 55 patients with Crohn's disease (mean duration 39 seconds) but in 5 of the 55 control subjects only (mean duration 19 seconds). There was no significant difference in skin temperature between the two groups. Intravital microscopy of nailfold capillaries revealed a marked reduction in capillary density (p less than 0.001) compared to normal subjects. The association of vasoconstrictive reaction in finger microcirculation of patients with Crohn's disease suggests a vasospastic tendency in this disorder.
Internmedizinische und chirurgische Abteilung, St. Claraspital Basel.
P
P
Gasser
H
H
Affolter
J P
JP
Schuppisser
U
U
Herzog
D000328:Adult; D001783:Blood Flow Velocity; D002196:Capillaries / Q000502:physiology; D003424:Crohn Disease / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006225:Hand / Q000098:blood supply*; D006801:Humans; D008297:Male; D008853:Microscopy / Q000379:methods; D008875:Middle Aged; D013035:Spasm / Q000209:etiology; D013256:Steroids / Q000627:therapeutic use; D012460:Sulfasalazine / Q000627:therapeutic use; D014652:Vascular Diseases / Q000209:etiology*
D013256:Steroids; D012460:Sulfasalazine
Akrale Vasospasmen bei M. Crohn.