Transgenic animal models of cardiovascular disease.
Transgenic experimentation has become a crucial part of hypertension and atherosclerosis research, and is growing more important in several other areas of cardiovascular disease. It has recently made a particular contribution to understanding the role of the renin-angiotensin system in controlling hypertension. The study of blood pressure regulation, cardiac hypertrophy, atherogenesis and thrombosis are also benefiting from the transgenic approach.
Centre for Genome Research, University of Edinburgh, UK.
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G
Barrett
J J
JJ
Mullins
D000818:Animals; D030801:Animals, Genetically Modified; D016632:Apolipoprotein A-I / Q000378:metabolism; D001161:Arteriosclerosis / Q000235:genetics / Q000503:physiopathology; D001794:Blood Pressure; D006332:Cardiomegaly / Q000235:genetics / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000235:genetics / Q000503:physiopathology*; D008076:Cholesterol, HDL / Q000097:blood; D004195:Disease Models, Animal; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology; D051379:Mice; D008822:Mice, Transgenic; D012083:Renin / Q000235:genetics; D012084:Renin-Angiotensin System / Q000235:genetics
D016632:Apolipoprotein A-I; D008076:Cholesterol, HDL; D012083:Renin