[Evaluation of a method for determining ACTH concentration in samples of serum obtained by catheterization of inferior petrosal sinuses in diagnosis of Cushing's disease].
A method consisting in the catheterization of lower petrosal sinuses aimed at obtaining blood samples for the determination of ACTH concentration has been applied in diagnostically difficult cases of Cushing's disease. The appearance of ACTH concentration gradient between the blood originating from the immediate vicinity of pituitary and the peripheral venous blood confirmed the hypophyseal etiology of hypercortisolemia. The gradient of ACTH concentration between the two petrosal sinuses made possible the localization of a microadenoma in the anterior lobe of pituitary. The diagnostic conclusions obtained by the above method have been confirmed during the surgery.
Klinika Neurochirurgii Instytutu Chirurgii AM, Warszawie.
W
W
Bonicki
W
W
Koszewski
A
A
Kasperlik-Załuska
A
A
Dowzenko
Z
Z
Sadowski
A
A
Andrzejewski
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D002404:Catheterization / Q000379:methods; D003480:Cushing Syndrome / Q000097:blood / Q000175:diagnosis*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017591:Petrosal Sinus Sampling / Q000379:methods*
D000324:Adrenocorticotropic Hormone
Wartość metody oznaczania poziomu hormonu ACTH w próbkach krwi uzyskanych poprzez cewnikowanie zatok skalistych dolnych w diagnostyce choroby Cushinga.