[An experimental evaluation of the acute and chronic oral toxicity of the antibiotic Bactericin for plant protection].
In relation to the future implementation of the antibiotic bactericin in agriculture are carried out acute, subacute and chronic oral experiments on 128 male white rats and 88 female. In order to determine the parameters of acute oral toxicity, doses (200, 120, 80, 60, 50, 40 mg/kg) of the preparation dissolved in polyethylene glycol are applied. In the subacute--1/10 and 1/20 LD50, and in the chronic (four months)--1/50 and 1/100 LD50. The bactericin, meant for treatment of tomatoes before sowing, in rate of acute oral toxicity falls in class II of very toxic pesticides. The acute oral LD50 for male white rats is 73.0 (48.6-109.5) mg/kg-1 and for female--58.0 (39.9-84.0) mg/kg-1. In conditions of subacute (30 oral applications for 45 days) and chronic (four months) experiments no cumulative properties are proved as well as hepatotoxic, nephrotoxic and neurotoxic effect. On the basis of the complex study could be accepted, that the dose 1/100 LD50 (0.7 mg/kg-1) for male rats and 0.4 mg/kg-1 for female) is not active at chronic oral introduction.
Antov
G
G
Zaĭkov
Kh
Kh
Khalkova
Zh
Zh
Mikhaĭlova
A
A
Shumkov
N
N
D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005659:Fungicides, Industrial / Q000008:administration & dosage / Q000633:toxicity*; D007928:Lethal Dose 50; D018942:Macrolides; D008297:Male; D011090:Polyenes / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D005659:Fungicides, Industrial; D018942:Macrolides; D011090:Polyenes; C089592:bactericin
Eksperimentalna otsenka na ostrata i khronichnata oralna toksichnost na antibiotika "Bakteritsin" za rastitelna zashtita.