In vivo microdialysis of amino acid neurotransmitters in the hippocampus in amygdaloid kindled rat.
Extracellular concentrations of gamma-aminobutyric acid (GABA), glutamate (Glu) and aspartate (Asp) were determined by microdialysis in rat hippocampus during various amygdaloid kindled stages. The values of GABA and Glu were increased 3-4 times in C2-C3 stages in comparison with the values in control animals. After reaching the C5 stages, these values were increased 3-7 times. However, the concentration of Asp decreased depending on the kindling stage, reaching the lowest value of 33% in comparison with the normal value. The observed changes may be related to kindling induced seizures.
Minamoto
Y
Y
Department of Physiology, Kagawa Medical School, Japan.
Itano
T
T
Tokuda
M
M
Matsui
H
H
Janjua
N A
NA
Hosokawa
K
K
Okada
Y
Y
Murakami
T H
TH
Negi
T
T
Hatase
O
O
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D003956:Dialysis / Q000379:methods; D004558:Electric Stimulation; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D006624:Hippocampus / Q000378:metabolism*; D007696:Kindling, Neurologic; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005971:Glutamates; D001224:Aspartic Acid; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid