The cell adhesion molecule L1 has a specific role in neural cell migration.
L1-transfected L cells show a markedly enhanced ability for neuronal cell binding and promotion of neuron migration compared with control L cells. Further, when purified L1 was used as a culture substrate for neurons, it was found to promote neuronal adhesion and enhance the speed of migration of cerebellar neurons from reaggregated cultures, indicating that it is involved in a determinant step of neural cell migration.
Asou
H
H
Department of Physiology, Keio University School of Medicine, Tokyo, Japan.
Miura
M
M
Kobayashi
M
M
Uyemura
K
K
D000818:Animals; D000831:Animals, Newborn; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D002478:Cells, Cultured; D002531:Cerebellum / Q000502:physiology*; D003001:Cloning, Molecular; D005455:Fluorescent Antibody Technique; D039841:Leukocyte L1 Antigen Complex; D051379:Mice; D009474:Neurons / Q000502:physiology*; D051381:Rats; D014162:Transfection
D015816:Cell Adhesion Molecules, Neuronal; D039841:Leukocyte L1 Antigen Complex