Bioactive polymers. 70. The kinetics of controlled release of neomycin in an alkaline medium.
Neomycin is coupled on xanthan--a polysaccharide of microbial biosynthesis produced by Xanthomona campestris--through ionic complexation. The kinetics of neomycin release, in vitro, at pH = 8.2 is studied. A release of neomycin, following a zero order kinetics, is observed, regardless of the eluent flow-rate. The neomycin-xanthan complex, protected by a cellulosic membrane, behaves like a monolithic-type device. Diffusion coefficients--increasing with increasing the eluent flow-rate--are also calculated.
Dumitriu
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Polytechnic Institute of Jassy, Romania.
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D003692:Delayed-Action Preparations; D004058:Diffusion; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D009355:Neomycin / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology; D011108:Polymers; D011135:Polysaccharides, Bacterial; D013211:Staphylococcus aureus / Q000187:drug effects
D003692:Delayed-Action Preparations; D011108:Polymers; D011135:Polysaccharides, Bacterial; D009355:Neomycin; C002563:xanthan gum