[The role of free fatty acids in the formation of cholelith].
Free fatty acids of bile were determined by gas chromatography in 57 patients with and without cholelithiasis. The results showed that 1. The percentage of free palmitic acid in total lipid was significantly higher in gallbladder stone group (0.38%) and duct stone group (0.32%) than that in control group (0.07%), P less than 0.05. 2. The percentage of free stearic acid and arachidonic acid was significantly higher in gallbladder stone group (0.08%, 0.09%) than that in control group (0.01%, 0.02%), P less than 0.05. Authors believed that the changes were related to the formation of fatty acid calcium in the stones and the oversecretion of prostaglandin in gallbladder.
Wang
Z Y
ZY
Dalian Medical College.
D000328:Adult; D000368:Aged; D016718:Arachidonic Acid / Q000378:metabolism; D001646:Bile / Q000378:metabolism*; D001649:Bile Duct Diseases / Q000378:metabolism; D002769:Cholelithiasis / Q000209:etiology / Q000378:metabolism*; D002849:Chromatography, Gas; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010169:Palmitic Acids / Q000378:metabolism; D013229:Stearic Acids / Q000378:metabolism
D005227:Fatty Acids; D010169:Palmitic Acids; D013229:Stearic Acids; D016718:Arachidonic Acid