title: Effects of supercypermethrin, a synthetic developmental pyrethroid, on four biological test systems.
abstract: The genotoxic potential of the insecticide supercypermethrin, a second-generation pyrethroid, was studied on four different test systems. It was non-mutagenic to Salmonella typhimurium strains TA1535, TA100, TA1538, TA98 and TA97 in the presence and absence of S9 mixture. It induced gene conversion at the tryptophan locus and induced point mutations at the isoleucine locus in Saccharomyces cerevisiae cells. A slight increase in the frequency of aberrant anaphases and telophases in root tips of Hordeum vulgare and Vicia faba was observed, but no genotoxic effects were detected in Drosophila melanogaster.
authors.affiliation: Department of Genetics and Molecular Biology, Comenius University, Faculty of Science, Bratislava, Czechoslovakia.
authors.forename: E
authors.initials: E
authors.lastname: Miadoková
authors.forename: V
authors.initials: V
authors.lastname: Vlcková
authors.forename: V
authors.initials: V
authors.lastname: Dúhová
authors.forename: M
authors.initials: M
authors.lastname: Trebatická
authors.forename: L
authors.initials: L
authors.lastname: Garajová
authors.forename: J
authors.initials: J
authors.lastname: Grolmus
authors.forename: S
authors.initials: S
authors.lastname: Podstavková
authors.forename: D
authors.initials: D
authors.lastname: Vlcek
mesh_terms: D000818:Animals; D001711:Biotransformation; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D004305:Dose-Response Relationship, Drug; D004331:Drosophila melanogaster / Q000187:drug effects / Q000235:genetics; D005785:Gene Conversion / Q000187:drug effects*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D010944:Plants / Q000187:drug effects / Q000235:genetics; D011722:Pyrethrins / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000235:genetics; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics; D012729:Sex Chromosome Aberrations
chemical_list: D009153:Mutagens; D011722:Pyrethrins; C017160:cypermethrin