Tc-99m HMPAO WBC imaging to detect carditis and to evaluate the results of high-dose gamma globulin treatment in Kawasaki disease.
Eighteen patients with Kawasaki disease and suspected carditis (11 boys, 7 girls, mean age 18 months) in acute stages underwent Tc-99m HMPAO WBC imaging of the heart. Signs and symptoms subsided after conventional aspirin therapy and the intravenous injection of high-dose (400 mg/kg per day for 5 days) gamma-globulin treatments. Tc-99m HMPAO WBC imaging of the heart was arranged a second time to evaluate the effects of the treatments for carditis. The results showed that a significant difference existed in the severity of carditis before and after the treatments (P less than 0.001, by signed rank test), 39% (7/18) with significant improvement in severity of carditis, 50% (9/18) without definite change. However, 11% (2/18) became more severely ill after the treatments. Tc-99m HMPAO WBC imaging may be useful in detecting carditis in Kawasaki disease and in evaluating the effects of aspirin plus the newly recommended gamma-globulin for the treatment of carditis in Kawasaki disease.
Kao
C H
CH
Department of Nuclear Medicine, Taichung, Veterans General Hospital, Taiwan, Republic of China.
Hsieh
K S
KS
Wang
Y L
YL
Chen
C W
CW
Liao
S Q
SQ
Wang
S J
SJ
Yeh
S H
SH
D002675:Child, Preschool; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D007223:Infant; D007962:Leukocytes; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications*; D009205:Myocarditis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000628:therapy; D015609:Organotechnetium Compounds; D010091:Oximes; D011877:Radionuclide Imaging; D019690:Technetium Tc 99m Exametazime; D005719:gamma-Globulins / Q000008:administration & dosage*
D015609:Organotechnetium Compounds; D010091:Oximes; D005719:gamma-Globulins; D019690:Technetium Tc 99m Exametazime