[Aztreonam or gentamicin combined with piperacillin as empiric antibiotic therapy during neutropenia of patients with hematologic diseases].
Fourty-two febrile episodes of 32 patients with hematologic disease during neutropenia were treated with two randomly assigned antibiotic combinations of either piperacillin plus gentamicin or piperacillin plus aztreonam. Eleven of the 22 febrile episodes treated with piperacillin plus gentamicin and 12 of the 20 febrile episodes treated with piperacillin plus aztreonam responded. Addition of cefamandole to non-responders improved the outcome in 2 of the 16 febrile episodes. Mean nadir leucocyte count, age, sex, and underlying disease were not significantly different in both groups. Side effects were tolerable in both groups, although 1 patient treated with piperacillin plus gentamicin showed severe renal impairment. Piperacillin plus aztreonam is as effective as piperacillin plus gentamicin as an empiric antibiotic combination in the treatment of febrile episodes with hematologic disease during neutropenia.
Murase
T
T
Department of Internal Medicine, Second Tokyo National Hospital.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000741:Anemia, Aplastic / Q000150:complications; D001398:Aztreonam / Q000008:administration & dosage*; D001424:Bacterial Infections / Q000188:drug therapy*; D002435:Cefamandole / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D005334:Fever / Q000188:drug therapy; D005839:Gentamicins / Q000008:administration & dosage; D006801:Humans; D007938:Leukemia / Q000150:complications*; D008223:Lymphoma / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000150:complications*; D010878:Piperacillin / Q000008:administration & dosage; D011446:Prospective Studies
D005839:Gentamicins; D002435:Cefamandole; D001398:Aztreonam; D010878:Piperacillin