title: Resolution of terfenadine enantiomers by beta-cyclodextrin chiral stationary phase high-performance liquid chromatography.
abstract: Enantiomers of terfenadine were resolved by high-performance liquid chromatography (HPLC) using a chiral stationary phase (CSP) column packed with beta-cyclodextrin (beta-CD) covalently bound to silica. Separation was achieved in both the reverse phase and normal phase modes. Resolution of enantiomers was confirmed by ultraviolet-visible absorption, circular dichroism, and mass spectral analysis.
authors.affiliation: Department of Pharmacology, Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine, Bethesda, Maryland 20814-4799.
authors.forename: H
authors.initials: H
authors.lastname: Weems
authors.forename: K
authors.initials: K
authors.lastname: Zamani
mesh_terms: D002851:Chromatography, High Pressure Liquid; D003505:Cyclodextrins; D006863:Hydrogen-Ion Concentration; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D016593:Terfenadine / Q000302:isolation & purification* / Q000378:metabolism; D047392:beta-Cyclodextrins
chemical_list: D003505:Cyclodextrins; D047392:beta-Cyclodextrins; D016593:Terfenadine; C031215:betadex