Dose-dependent enzyme suppression in spleen induced by GM1 (monosialoganglioside 1) administration to mice.
Our previous studies suggested that the administration of exogenous gangliosides to the body modulates enzymatic networks in the brain. In the present study, we tested whether that is the case with another organ, spleen. By testing the dose response relationship, we found that there is a optimum dose for the effect of enzymatic modulation of GM1 (monosialoganglioside 1) administration. Although the optimum level varied depending on each of the examined hydrolytic enzymes, it usually fell in the range around 50 micrograms/kg body weight. The findings led us to conclude that the enzyme-modulating actions of gangliosides come not merely from the bizarre actions in vivo of high molecular exogenous substances.
Aoyagi
T
T
Institute of Microbial Chemistry, Tokyo, Japan.
Osanai
T
T
Wada
T
T
Kojima
F
F
Nagai
M
M
Harada
S
S
Takeuchi
T
T
Nagai
Y
Y
D000818:Animals; D001923:Brain Chemistry; D004305:Dose-Response Relationship, Drug; D005677:G(M1) Ganglioside / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000187:drug effects / Q000201:enzymology*
D005677:G(M1) Ganglioside