Carrier sequence selection--one key to successful vaccines.
The trend towards epitopic vaccines has brought with it the problem of ensuring carrier function, a role previously filled by carrier sequences of the attenuated organism. Here, Howard Etlinger proposes the use of carrier epitopes, derived from vaccines already in use and selected for their ability to activate only helper T-cell responses, in the administration of B-cell-specific epitopic vaccines.
Etlinger
H M
HM
Pharmaceutical Research New Technologies, F. Hoffmann-La Roche and Co. Ltd., Basel, Switzerland.
D000595:Amino Acid Sequence; D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D000939:Epitopes / Q000276:immunology*; D000922:Immunotoxins / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D015800:Protozoan Proteins / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D013744:Tetanus Toxin / Q000276:immunology; D014612:Vaccines / Q000276:immunology*
D000953:Antigens, Protozoan; D000939:Epitopes; D000922:Immunotoxins; D015800:Protozoan Proteins; D013744:Tetanus Toxin; D014612:Vaccines; C041595:circumsporozoite protein, Protozoan