Enhancement of trinitrophenyl-specific humoral response to TNP proteins as the result of carrier chlorination.
Trinitrophenyl (TNP)-specific humoral response was tested after immunization with TNP-protein conjugates composed of either native proteins or proteins modified by chlorination. Significant enhancement of the hapten-specific response was observed as a result of carrier chlorination. This effect was dose dependent and affected mainly T-helper-cell activation. Since stimulated neutrophils chlorinate in vivo proteins, we propose that they take part in the induction phase of immune response by facilitation of antigen processing and/or presentation.
Marcinkiewicz
J
J
Department of Immunology, Copernicus School of Medicine, Cracow, Poland.
Olszowska
E
E
Olszowski
S
S
Zgliczynski
J M
JM
D000818:Animals; D000917:Antibody Formation; D006241:Haptens / Q000276:immunology; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D012710:Serum Albumin, Bovine / Q000276:immunology; D013997:Time Factors; D014301:Trinitrobenzenes / Q000276:immunology*; D010948:Viral Plaque Assay; D005719:gamma-Globulins / Q000276:immunology
D006241:Haptens; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D014301:Trinitrobenzenes; D005719:gamma-Globulins; D012710:Serum Albumin, Bovine