Antiallergic properties of the second-generation H1 antihistamines during the early and late reactions to antigen.
Some of the second-generation H1 antihistamines reduce the bronchoconstrictor response after exercise and antigen challenge. For example, terfenadine causes a slight but significant increase in forced expiratory volume after 1 second. At doses of 120 and 240 mg, terfenadine has a protective effect against asthma induced by ultrasonic nebulized distilled water and cold air hyperventilation challenge. Certain other newer antihistamines, such as ketotifen, azelastine, and cetirizine, have additional antiallergy properties. These effects include inhibition of eosinophil, basophil, and neutrophil migration and platelet-activating factor-induced eosinophil accumulation in skin. The ability of cetirizine (and perhaps other antihistamines) to inhibit these responses at usual therapeutic doses may be useful in investigating the late allergic reaction.
Townley
R G
RG
Department of Medicine, Creighton University School of Medicine, Omaha, Neb. 68178.
D000941:Antigens / Q000008:administration & dosage; D001249:Asthma / Q000188:drug therapy*; D017332:Cetirizine / Q000494:pharmacology; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D003080:Cold Temperature; D005541:Forced Expiratory Volume; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D009299:Nasal Provocation Tests; D009504:Neutrophils / Q000276:immunology; D005082:Physical Exertion; D013189:SRS-A / Q000378:metabolism; D012882:Skin Tests; D016593:Terfenadine / Q000627:therapeutic use; D013997:Time Factors
D000941:Antigens; D006634:Histamine H1 Antagonists; D013189:SRS-A; D016593:Terfenadine; D017332:Cetirizine