title: Bayesian restoration of single-channel patch clamp recordings.
abstract: The technique of patch clamp recording makes possible the measurement of current flowing through a single ion channel in a cell membrane. Examination of such recordings suggests that the current is quantal in nature, alternating in a seemingly random manner between "on" and "off," but the recordings are corrupted by noise from a variety of sources. In this paper we propose and illustrate methods for restoring the underlying quantal signal from such noisy measurements. The methods use a Markov chain prior distribution for the underlying quantal process and base the restoration on the resulting posterior distribution.
authors.affiliation: Department of Physics, University of California, San Diego, La Jolla 92093.
authors.forename: D R
authors.initials: DR
authors.lastname: Fredkin
authors.forename: J A
authors.initials: JA
authors.lastname: Rice
mesh_terms: D000465:Algorithms; D000818:Animals; D001699:Biometry; D018118:Chloride Channels; D007473:Ion Channels / Q000502:physiology*; D008433:Mathematics; D008565:Membrane Proteins / Q000502:physiology; D008954:Models, Biological; D009474:Neurons / Q000502:physiology; D009865:Oocytes / Q000502:physiology; D051381:Rats; D011978:Receptors, Nicotinic / Q000235:genetics / Q000502:physiology; D015222:Sodium Channels / Q000502:physiology; D013269:Stochastic Processes
chemical_list: D018118:Chloride Channels; D007473:Ion Channels; D008565:Membrane Proteins; D011978:Receptors, Nicotinic; D015222:Sodium Channels