A critical review of the toxicology of glutaraldehyde.
Glutaraldehyde, a low molecular weight aldehyde, has been investigated for toxicity in humans and animals. Examination of this dialdehyde was indicated from previous studies with other aldehydes in which carcinogenicity of formaldehyde and toxicity of acetaldehyde and malonaldehyde have been disclosed. Information gaps concerning the actions of glutaraldehyde have been identified in this review and recommendations are suggested for additional short- and long-term studies. In particular, information regarding irritation of the respiratory tract, potential neurotoxicity, and developmental effects would assist in a complete hazard evaluation of glutaraldehyde. Further study related to disposition, metabolism, and reactions of glutaraldehyde may elucidate the mechanism of action.
Beauchamp
R O
RO
CIIT, Research Triangle Park, NC 27709.
St Clair
M B
MB
Fennell
T R
TR
Clarke
D O
DO
Morgan
K T
KT
Kari
F W
FW
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D009783:Dermatitis, Occupational / Q000209:etiology*; D004285:Dogs; D005314:Embryonic and Fetal Development / Q000187:drug effects; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D005976:Glutaral / Q000009:adverse effects* / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D006168:Guinea Pigs; D006801:Humans; D007509:Irritants / Q000009:adverse effects; D007928:Lethal Dose 50; D008452:Maximum Allowable Concentration; D051379:Mice; D009152:Mutagenicity Tests; D016273:Occupational Exposure / Q000009:adverse effects*; D011817:Rabbits; D051381:Rats; D012140:Respiratory Tract Diseases / Q000139:chemically induced*; D014481:United States; D014489:United States Occupational Safety and Health Administration
D007509:Irritants; D005976:Glutaral