title: All-trans retinoic acid in acute promyelocytic leukemia: preliminary results in Cuba.
abstract: Seven patients with acute promyelocytic leukemia (APL) were treated with all-trans retinoic acid (ATRA). Five (71.4%) achieved complete remission (CR). Most side effects were transient and well tolerated. Hyperleukocytosis was the major adverse effect. These observations confirm the efficacy of ATRA for inducing CR in APL.
authors.affiliation: Instituto de Hematologia e Inmunologia, Ciudad de La Habana, Cuba.
authors.forename: P
authors.initials: P
authors.lastname: Hernández
authors.forename: J
authors.initials: J
authors.lastname: Carnot
authors.forename: E
authors.initials: E
authors.lastname: Dorticós
authors.forename: E
authors.initials: E
authors.lastname: Espinosa
authors.forename: A
authors.initials: A
authors.lastname: González
authors.forename: I
authors.initials: I
authors.lastname: Rodríguez
mesh_terms: D000328:Adult; D003462:Cuba; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy*; D008297:Male; D013237:Stereoisomerism; D014212:Tretinoin / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D014212:Tretinoin