title: Determination of estrogen and progesterone receptors in endometrial adenocarcinomas. Comparison between dextran-coated charcoal and immunoenzymatic methods on curettage biopsies.
abstract: Estrogen receptors (ER) and progesterone receptors (PR) were determined on curettages from women with endometrial adenocarcinoma. The results obtained with the enzyme immunoassay (EIA) and the dextran-coated charcoal (DCC) assay were compared. A highly significant correlation was obtained between these methods for the ER measurement (Rs = 0.91). For PR determination, the Rs value between EIA and DCC assay was 0.57 and the mean value of PR-DCC is significantly higher than the mean value of PR-EIA. These results suggest that EIA is a suitable method for ER measurement. For PR determination on curettage material the DCC assay seems more accurate than EIA.
authors.affiliation: Centre Alexis Vautrin, Vandoeuvre les Nancy, France.
authors.forename: S
authors.initials: S
authors.lastname: Marchal
authors.forename: C
authors.initials: C
authors.lastname: Marchal
authors.forename: S
authors.initials: S
authors.lastname: Hoffstetter
authors.forename: R M
authors.initials: RM
authors.lastname: Parache
authors.forename: M
authors.initials: M
authors.lastname: Pernot
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry* / Q000473:pathology; D000328:Adult; D000368:Aged; D001706:Biopsy; D002606:Charcoal; D003911:Dextrans; D004714:Endometrial Hyperplasia; D016889:Endometrial Neoplasms / Q000737:chemistry* / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*
chemical_list: D003911:Dextrans; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D002606:Charcoal