[Effect of electroacupuncture on myocardial oxygen metabolism and pH of coronary sinus blood during experimental angina pectoris].
The experiments were performed on 30 healthy mongrel dogs, intubation was taken in the left anterior descending coronary (LAD), the blood in carotid was transported to LAD through a peristalic pump, the blood flow was reduced to 3-5 ml/min, thus acute myocardial ischemia was produced. Basing on this condition, 0.1-0.16 ml bradykinin (2 ug/ml) was given into LAD coronary before recording to produce angina pectoris. The effects of electroacupuncture (EA) at "Neiguan" area on myocardial oxygen metabolism, pH of coronary sinus blood and myocardial contractile force were observed (EA intensity 5 volts, frequency 1-20 Hz). The results are as follows: 1. EA could reduce obviously A-V difference of blood oxygen capacity (Ca-vO2) and the rate of myocardium extracting oxygen (O2E), thus reduced obviously oxygen consumption of ischemic myocardium. 2. EA could reduce V-A difference of carbon dioxide partial pressure (Pv-aCO2), prevent the decrease of pH of coronary sinus blood (PHv), this indicated that EA could prevent accumulation of acidic metabolic products. 3. EA could increase myocardial developed tension (DT) of ischemic area, strengthen myocardial contractile force of ischemic area. Above results indicated that EA could reduce oxygen consumption of ischemic myocardium, prevent the decrease of pH of coronary sinus blood, thus myocardial cell acidosis was prevented, myocardial contractile force was strengthened. It might be the mechanism of acupuncture treating coronary heart disease.
Gao
C
C
Institute of Acupuncture and Moxibustion, China Academy of Traditional Chinese Medicine, Beijing.
Meng
J
J
Fu
W
W
Song
L
L
D000787:Angina Pectoris / Q000378:metabolism* / Q000628:therapy*; D000818:Animals; D003331:Coronary Vessels; D004285:Dogs; D015671:Electroacupuncture; D006863:Hydrogen-Ion Concentration; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption