High prevalence of Clostridium difficile diarrhoea during intensive chemotherapy for disseminated germ cell cancer.
A prospective, consecutive study of the aetiology of treatment-associated diarrhoea was conducted in 25 patients with disseminated germ cell cancer treated with intensive chemotherapy. Clostridium difficile was isolated in 45% of the diarrhoea episodes, which makes this species the most important bacterial pathogen in the development of clinically significant diarrhoea in this group of immunocompromised patients.
Nielsen
H
H
Department of Clinical Microbiology, Rigshopitalet, Copenhagen, Denmark.
Daugaard
G
G
Tvede
M
M
Bruun
B
B
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D016360:Clostridioides difficile / Q000302:isolation & purification*; D003967:Diarrhea / Q000188:drug therapy / Q000382:microbiology*; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D016867:Immunocompromised Host; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy*; D015995:Prevalence; D011446:Prospective Studies
D001761:Bleomycin; D005047:Etoposide; D002945:Cisplatin