title: Exploiting the chemical synthesis of RNA.
abstract: A number of nucleotide phosphoramidites are now available that permit the chemical synthesis of RNA, modified RNA and RNA-DNA chimeric oligonucleotides. Since the chemical strategy allows the introduction of a particular modification at any given site in a nucleotide polymer, very subtle and specific questions regarding structure-function relationships in RNA may be addressed.
authors.affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.
authors.forename: N
authors.initials: N
authors.lastname: Usman
authors.forename: R
authors.initials: R
authors.lastname: Cedergren
mesh_terms: D001483:Base Sequence; D002678:Chimera; D004247:DNA / Q000737:chemistry; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D012313:RNA / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D012313:RNA; D004247:DNA