Fast systematic approach for the determination of drugs in biological fluids by fully automated high-performance liquid chromatography with on-line solid-phase extraction and automated cartridge exchange. Application to cebaracetam in human urine.
A fast stepwise systematic approach for the conversion of conventional reversed-phase high-performance liquid chromatographic (HPLC) assays involving liquid-liquid extraction of biological fluids into fully automated HPLC assays using solid-phase extraction and cartridge exchange is described. The suitability of this procedure is demonstrated for the determination of cebaracetam in human urine.
Chollet
D
D
Department of Toxicology and Pharmacokinetics, Zyma S.A., Nyon, Switzerland.
Künstner
P
P
D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation; D006801:Humans; D010879:Piperazines / Q000652:urine*; D011619:Psychotropic Drugs / Q000652:urine*; D015203:Reproducibility of Results; D013056:Spectrophotometry, Ultraviolet
D010879:Piperazines; D011619:Psychotropic Drugs; C077252:cebaracetam