title: Karyotype evolution in a patient with biphenotypic neonatal leukemia.
abstract: We present the case of a 4-day-old boy with acute lymphoblastic leukemia showing at onset a karyotype 46,XY,t(4;11)(q21;q23). At relapse an additional change, add(2), was present. Molecular analysis showed the same immunoglobulin rearrangement both at onset and at relapse, but immunohistochemical analysis revealed some cells having myeloid features. A continuous cell line derived from the leukemic blasts of the patient presented typical monoblastic features.
authors.affiliation: Department of Biology and Genetics, University of Genova, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Fugazza
authors.forename: G
authors.initials: G
authors.lastname: Basso
authors.forename: M
authors.initials: M
authors.lastname: Sessarego
authors.forename: R
authors.initials: R
authors.lastname: Haupt
authors.forename: A
authors.initials: A
authors.lastname: Comelli
authors.forename: S
authors.initials: S
authors.lastname: Roncella
authors.forename: D
authors.initials: D
authors.lastname: Negri
authors.forename: R
authors.initials: R
authors.lastname: Sansone
mesh_terms: D002460:Cell Line; D002880:Chromosomes, Human, Pair 11; D002894:Chromosomes, Human, Pair 4; D015321:Gene Rearrangement; D006801:Humans; D016130:Immunophenotyping; D007231:Infant, Newborn; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000151:congenital* / Q000235:genetics; D007951:Leukemia, Myeloid / Q000151:congenital* / Q000235:genetics; D008297:Male; D014178:Translocation, Genetic