[Effects of IL-1 and TNF-alpha on the in vitro growth of fibroblasts].
Purified mouse IL-1 at doses higher than 5 u/ml strongly inhibits the growth of passaged rabbit bone marrow fibroblasts. Rec, human TNF-alpha at doses 0.05-3 u/ml slightly stimulates and at higher doses inhibits the in vitro growth of passaged fibroblasts from rabbit and human bone marrow. At the same time the in vitro growth of human skin fibroblasts is stimulated by rec. human TNF-alpha.
Gorskaia
Iu F
IuF
D000818:Animals; D001854:Bone Marrow Cells; D002455:Cell Division; D002478:Cells, Cultured; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D051379:Mice; D011817:Rabbits; D012867:Skin / Q000166:cytology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha