Structure-activity relationships for unsaturated dialdehydes. 6. The mutagenic activity of 11 compounds in the V79/HGPRT assay.
The mutagenic activity of 11 sesquiterpenoid unsaturated dialdehydes in the V79/HGPRT assay has been determined, and is compared with previously published data on the mutagenicity of the same compounds towards Ames Salmonella strains. One compound, isovelleral, is a potent mutagen in both assays, while six compounds, which are positive in the Ames Salmonella/microsome assay, show no significant activity in this study. One compound, acetylmerulidial, is negative in the Ames Salmonella/microsome assay but significantly although weakly mutagenic in the V79/HGPRT assay. The remaining three compounds are inactive in both assays. The study is part of a general investigation of quantitative structure-activity relationships for unsaturated dialdehydes, a class of natural occurring compounds known for their potent and numerous biological activities.
Morales
P
P
Department of Organic Chemistry 2, Lund Institute of Technology, University of Lund, Sweden.
Andersson
M
M
Lewan
L
L
Sterner
O
O
D000447:Aldehydes / Q000737:chemistry* / Q000633:toxicity*; D000818:Animals; D006224:Cricetinae; D003412:Cricetulus; D005796:Genes; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D016296:Mutagenesis; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000633:toxicity*; D013329:Structure-Activity Relationship
D000447:Aldehydes; D009153:Mutagens; D012717:Sesquiterpenes; D007041:Hypoxanthine Phosphoribosyltransferase