Inhibition of neutrophil chemotactic factor production in comedonal bacteria by subminimal inhibitory concentrations of erythromycin.
The effect of 1/10 minimal inhibitory concentrations (sub-MIC) of erythromycin (EM) on human neutrophil chemotactic factor production in comedonal bacteria, Propionibacterium acnes strains, Propionibacterium granulosum strains and coagulase-negative staphylococcus (CNS) strains was assayed using the Boyden chamber method. Sub-MIC of EM significantly suppressed neutrophil chemotactic factor production in all strains of P. acnes, P. granulosum and CNS. Our results suggest that sub-MIC of EM may have an anti-inflammatory action by reducing the inflammatory capacity of comedonal bacteria in inflammatory acne.
Akamatsu
H
H
Department of Dermatology, Kansai Medical University, Osaka, Japan.
Kurokawa
I
I
Nishijima
S
S
Asada
Y
Y
D000152:Acne Vulgaris / Q000188:drug therapy / Q000382:microbiology* / Q000503:physiopathology; D004917:Erythromycin / Q000494:pharmacology*; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology*; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism*; D011425:Propionibacterium acnes / Q000187:drug effects*
D016209:Interleukin-8; D004917:Erythromycin