[Intracochlear electrical stimulation of the auditory nerve in deaf kittens--brainstem response audiometric and histopathologic studies].
The effects of long-term electrical stimulation of the auditory nerve on the morphology of the cochlear nucleus were investigated in young pharmacologically deafened kittens. Comparing the amplitude of EABR with the soma area, there was a strong positive correlation between the amplitude of EABR and the soma area of neurons within the anterior ventral cochlear nucleus on the stimulated side. However, there was no correlation between the amplitude of EABR and the soma area of neurons within the unstimulated anterior ventral cochlear nucleus. In addition, there was no correlation between the amplitude of EABR and the survival rate of spiral ganglion cells. This showed that EABR may be affected not only by the survival rate of the spiral ganglion cell, but also by the development of the central auditory nervous system in kittens, which were deafened under the development of the central auditory nervous system.
Matsushima
J
J
Department of Otolaryngology, Hokkaido University School of Medicine, Sapporo.
Inuyama
Y
Y
D000818:Animals; D002415:Cats; D003051:Cochlea / Q000473:pathology*; D003638:Deafness / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D000159:Vestibulocochlear Nerve / Q000503:physiopathology*