Effect of recombinant human granulocyte colony-stimulating factor on survival in lethally irradiated mice.
Repeated injections of recombinant human granulocyte colony-stimulating factor (rhG-CSF) to lethally irradiated mice increased the rate of animal survival. Dose modification factor was 1.20 when 4.5 micrograms/mouse of rhG-CSF was given daily for 14 days after whole body irradiation. Haematological examinations revealed that rhG-CSF increased the number of blood-circulating leukocytes, neutrophils, monocytes and erythrocytes, but not that of lymphocytes and thrombocytes. Spleen weight and number of endogenous spleen colonies were also increased by rhG-CSF treatment compared with the values for mice irradiated only.
Hosoi
Y
Y
Department of Radiation Research, Tohoku University School of Medicine, Sendai, Japan.
Kurishita
A
A
Ono
T
T
Sakamoto
K
K
D000818:Animals; D003114:Colony-Forming Units Assay; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D004906:Erythrocyte Count / Q000187:drug effects / Q000528:radiation effects*; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009929:Organ Size / Q000187:drug effects / Q000528:radiation effects; D010976:Platelet Count / Q000187:drug effects / Q000528:radiation effects*; D011833:Radiation Injuries, Experimental / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use*; D013154:Spleen / Q000187:drug effects / Q000528:radiation effects; D013997:Time Factors; D014916:Whole-Body Irradiation; D014965:X-Rays
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor