Chromosome aberrations in an alpha-fetoprotein-producing hepatoblastoma.
The cytogenetic findings of an alpha-fetoprotein (AFP)-producing hepatoblastoma in a 14-month-old girl are reported. Ten of 36 tumor cells were chromosomally abnormal, yielding the composite karyotype 47,XX,2q +, t(3;5)(p25;q31),dup(4)(q12q26), +20. Three of the chromosomal abnormalities (2q+, break at 4q12, +20) have been reported previously and might be of pathogenetic significance.
Annerén
G
G
Department of Clinical Genetics, University Hospital, Uppsala, Sweden.
Nordlinder
H
H
Hedborg
F
F
D000782:Aneuploidy; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002889:Chromosomes, Human, Pair 2 / Q000648:ultrastructure; D002890:Chromosomes, Human, Pair 20; D002893:Chromosomes, Human, Pair 3 / Q000648:ultrastructure; D002894:Chromosomes, Human, Pair 4 / Q000648:ultrastructure; D002895:Chromosomes, Human, Pair 5 / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D009363:Neoplasm Proteins / Q000378:metabolism*; D014178:Translocation, Genetic; D000509:alpha-Fetoproteins / Q000378:metabolism*
D009363:Neoplasm Proteins; D000509:alpha-Fetoproteins