[t-PA and PAI in patients with Raynaud's syndrome in treatment with a stable prostacyclin analog].
An study was made in order to determinate the relationship between the restoration of the local fibrinolytic activity and the clinical signs in patients with a Raynaud's phenomenon. It is known that local fibrinolytic activity is a system influenced by changes into its components produced by exogenous and endogenous factors. An important role is represented by the t-PA and PAI-1. On the contrary, u-PA doesn't change. Samples were all taken at the same time, approximately at the middle of the morning. In patients with Raynaud's phenomenon treated with a prostacyclin stable analogous, we have perceived a clinical improvement, corresponding with a fibrinolytic activity increase.
Pola
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Divisione di Angiologia, Università Cattolica del Sacro Cuore, Roma, Italia.
de Martini
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D
Gerardino
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L
D000328:Adult; D000368:Aged; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D016285:Iloprost / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D015849:Plasminogen Inactivators / Q000097:blood*; D011928:Raynaud Disease / Q000097:blood* / Q000188:drug therapy; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000097:blood* / Q000187:drug effects
D015849:Plasminogen Inactivators; D010959:Tissue Plasminogen Activator; D016285:Iloprost