title: Inhibition of cell division initiation by an imbalance in the ratio of FtsA to FtsZ.
abstract: Elevated levels of FtsA protein block cell division at a very early stage, similar to that caused by inhibition of the action of FtsZ. In contrast, overexpression of FtsA and FtsZ together does not block division. A specific ratio of FtsA to FtsZ protein, therefore, is required for cell division.
authors.affiliation: Institute of Cell & Molecular Biology, University of Edinburgh, Scotland.
authors.forename: S J
authors.initials: SJ
authors.lastname: Dewar
authors.forename: K J
authors.initials: KJ
authors.lastname: Begg
authors.forename: W D
authors.initials: WD
authors.lastname: Donachie
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D002455:Cell Division / Q000502:physiology; D003598:Cytoskeletal Proteins; D004926:Escherichia coli / Q000166:cytology / Q000502:physiology*; D029968:Escherichia coli Proteins
chemical_list: D001426:Bacterial Proteins; D003598:Cytoskeletal Proteins; D029968:Escherichia coli Proteins; C065103:FtsA protein, Bacteria; C489310:FtsA protein, E coli; C071525:FtsZ protein, Bacteria