title: Residual platelet function under acetylsalicylic acid and the risk of restenosis after coronary angioplasty.
abstract: Restenosis after percutaneous transluminal coronary angioplasty (PTCA) was shown not to be preventable by antiplatelet therapy; residual platelet function under treatment with platelet inhibitors could be one cause of this. Therefore, in a prospective investigation, residual platelet function was assessed in 98 patients treated with acetylsalicylic acid (ASA) on three occasions during the first 3 months after successful PTCA. Control cardiac catheterization was obtained in 75 of these patients (77%) with 82 dilated stenoses 173 +/- 117 days after PTCA. Restenosis, defined as diameter stenosis greater than or equal to 50% at control angiography, occurred in 41% of the dilated vessels, and 43% of patients experienced restenosis in at least one vessel. The in vitro platelet aggregatory response to either ADP (0.5, 1, and 10 microM) or collagen (1 and 5 mg/L) as aggregating agents did not differ between patients with and without restenosis. In addition, neither the collagen-stimulated in vitro synthesis of thromboxane nor the basal or prostaglandin E1-stimulated concentrations of cyclic AMP in platelet-rich plasma (PRP) was different in the two groups. There was no significant correlation between any of the parameters of platelet function assessed and the change in coronary luminal diameter observed between immediately after PTCA and control coronary angiography. The mean dose of ASA ingested during follow-up was also not a determinant of the occurrence of restenosis. Thus, residual platelet function under treatment with ASA as measured in vitro in this study, did not influence the occurrence of restenosis after successful PTCA.
authors.affiliation: Department of Cardiology, Eppendorf University Hospital, Hamburg, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Terres
authors.forename: C W
authors.initials: CW
authors.lastname: Hamm
authors.forename: A
authors.initials: A
authors.lastname: Ruchelka
authors.forename: A
authors.initials: A
authors.lastname: Weilepp
authors.forename: W
authors.initials: W
authors.lastname: Kupper
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D003327:Coronary Disease / Q000097:blood / Q000628:therapy*; D000242:Cyclic AMP / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D012008:Recurrence; D013929:Thromboxane B2 / Q000032:analysis / Q000096:biosynthesis
chemical_list: D013929:Thromboxane B2; D000242:Cyclic AMP; D001241:Aspirin