title: Cytogenetic abnormalities in renal oncocytic neoplasms.
abstract: We have performed cytogenetic studies on five renal oncocytic neoplasms (three grade 2 tumors and two grade 1 tumors) identified histologically by light microscopy. One grade 1 tumor failed to produce mitotic cells. The other four tumors exhibited both normal and abnormal cell lines. Numerical abnormalities were found in both the single grade 1 and two of the grade 2 tumors whereas structural abnormalities were limited to grade 2 tumors. Aneuploidy of chromosome 12 was observed in both grade 1 and 2 tumors. Grade 2 tumors showed more extensive numerical change than the grade 1 tumors. Abnormalities of chromosome 3 characteristic of renal cell carcinoma were not found in any tumor in this series. A combination of C-banding and HaeIII endonuclease banding was used to identify an ambiguous marker. In our four cases and in the cases previously reported, loss of a sex chromosome, abnormalities of chromosomes 1 and 22, and trisomy 12 are findings most often observed in renal oncocytoma.
authors.affiliation: Department of Pathology, Scott and White Hospital, Scott, Sherwood and Brindley Foundation, Texas A&M University College of Medicine, Temple 76508.
authors.forename: S M
authors.initials: SM
authors.lastname: Dobin
authors.forename: C P
authors.initials: CP
authors.lastname: Harris
authors.forename: J A
authors.initials: JA
authors.lastname: Reynolds
authors.forename: K S
authors.initials: KS
authors.lastname: Coffield
authors.forename: R C
authors.initials: RC
authors.lastname: Klugo
authors.forename: R F
authors.initials: RF
authors.lastname: Peterson
authors.forename: V O
authors.initials: VO
authors.lastname: Speights
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D002277:Carcinoma / Q000235:genetics* / Q000473:pathology; D002292:Carcinoma, Renal Cell; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D014407:Tumor Cells, Cultured / Q000648:ultrastructure
chemical_list: D014408:Biomarkers, Tumor; D005819:Genetic Markers