title: Diffusion of cloxacillin into synovial tissue.
abstract: After a 30 min i.v. infusion of 1 g cloxacillin, the concentrations of this antibiotic were measured in plasma and synovial tissue samples from 11 patients undergoing total hip replacement. Assuming passive distribution between plasma and tissue the rate constants of distribution were estimated. The mean half-life of distribution was 22 min. The concentration of free drug in synovial tissue was estimated to be 77% of the total tissue concentration. The maximum tissue drug concentration after an i.v. bolus dose is predicted to occur at about 37 min.
authors.affiliation: University Hospital, Department of Infectious Diseases, Leiden, The Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Mattie
authors.forename: S
authors.initials: S
authors.lastname: De Marie
authors.forename: G
authors.initials: G
authors.lastname: Slaghuis
authors.forename: P M
authors.initials: PM
authors.lastname: Rozing
authors.forename: E
authors.initials: E
authors.lastname: Van Strijen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003023:Cloxacillin / Q000097:blood / Q000493:pharmacokinetics*; D004058:Diffusion; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013583:Synovial Membrane / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D003023:Cloxacillin