Selected ion monitoring for the determination of bromovalerylurea in human plasma.
A gas chromatography-selected ion monitoring procedure with chemical ionization is described for the determination of bromovalerylurea (BVU) in human plasma. BVU was extracted with ether after addition of 2-bromo-2-methylpropylurea as an internal standard. The lower limit of BVU quantification by this method was 2 ng/0.1 ml plasma volume. This procedure was used to determine the sequential plasma levels of BVU in a human volunteer following a single oral dose of a commercial analgesic.
Kokatsu
J
J
Research Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Yomoda
R
R
Suwa
T
T
D000284:Administration, Oral; D000328:Adult; D001968:Bromisovalum / Q000008:administration & dosage / Q000097:blood*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male
D001968:Bromisovalum