Prolonged shelf stability and biocompatibility of a concentrated injectable fluorocarbon emulsion.
A four-year-old 100% w/v concentrated emulsion of perfluorooctylbromide (PFOB, perflubron) stored at 5 degrees C, when submitted to the close-to-total exchange-perfusion test in conscious rats (Hct 3-5%) still resulted in 75% survival. Particle size and size distribution, viscosity, pH were still in the acceptable range.
Follana
R
R
Centre Départemental de Transfusion Sanguine, Laurent du Var, France.
Klein
D
D
Krafft
M P
MP
Long
D M
DM
Long
C D
CD
Ni
Y
Y
Riess
J G
JG
Valla
A
A
D000818:Animals; D001802:Blood Substitutes / Q000008:administration & dosage; D004355:Drug Stability; D004655:Emulsions; D005078:Exchange Transfusion, Whole Blood; D005466:Fluorocarbons / Q000008:administration & dosage; D006842:Hydrocarbons, Brominated; D008422:Materials Testing; D051381:Rats; D013997:Time Factors
D001802:Blood Substitutes; D004655:Emulsions; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; C003072:perflubron