title: No secular increase in the prevalence of vertebral fractures due to postmenopausal osteoporosis.
abstract: We examined whether the prevalence of vertebral fractures in otherwise healthy, 70-year-old Danish women had increased during an interval of 10 years. The population-based epidemiological study included two age-matched groups of postmenopausal women. Group 1 consisted of 70-year-old women (n = 386) living in a defined area of suburban Copenhagen recruited in 1979 for an epidemiological study. Of the 285 women who were entered, 173 were judged healthy, without secondary causes of osteoporosis. Group 2 was recruited by sending questionnaires to all women aged 68-72 years living in the same area in 1989. Of the 512 women who attended a medical screening, 387 were found to be without secondary causes of osteoporosis and had a spinal radiograph. Radiographs of the thoracolumbar spine were assessed for vertebral fracture by five radiological methods. There was no significant difference between the two groups in the prevalence of vertebral fractures and the 95% confidence intervals overlapped completely in all methods. The prevalence rates varied by method from about 35% to more than 80% but the distribution of fracture types was similar in the two groups. We conclude that the prevalence of vertebral fractures due to postmenopausal osteoporosis has not increased since 1979 in otherwise healthy women residing in suburban Copenhagen, and that comparison of prevalences between studies requires that they use the same method of radiological assessment.
authors.affiliation: Department of Clinical Chemistry, Glostrup Hospital, University of Copenhagen, Denmark.
authors.forename: M A
authors.initials: MA
authors.lastname: Hansen
authors.forename: K
authors.initials: K
authors.lastname: Overgaard
authors.forename: V A
authors.initials: VA
authors.lastname: Nielsen
authors.forename: G F
authors.initials: GF
authors.lastname: Jensen
authors.forename: A
authors.initials: A
authors.lastname: Gotfredsen
authors.forename: C
authors.initials: C
authors.lastname: Christiansen
mesh_terms: D000368:Aged; D003718:Denmark; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D015663:Osteoporosis, Postmenopausal / Q000150:complications* / Q000628:therapy; D015995:Prevalence; D011859:Radiography; D011871:Radiology / Q000379:methods; D016103:Spinal Fractures / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology*