title: Microrips of the retinal pigment epithelium.
abstract: We describe six patients with exudative age-related macular degeneration who had retinal pigment epithelial detachments with associated overlying neurosensory detachments. During fluorescein angiography, each patient demonstrated a solitary, intense, central serouslike leak at the edge of the retinal pigment epithelial detachment with passage of fluorescein into the subretinal space. In patients in whom the location of associated choroidal neovascularization was evident, the leakage site was remote to the area of neovascularization. Our observations suggest that these leaks result from small retinal epithelial rips, which we termed "microrips," that differ from conventionally described retinal pigment epithelial rips in clinical course and response to laser treatment. We hypothesize that the mechanisms and forces that generate these microrips are different from those producing conventionally described retinal pigment epithelial rips.
authors.affiliation: Department of Ophthalmology, Manhattan Eye, Ear, and Throat Hospital, New York, NY 10021.
authors.forename: D
authors.initials: D
authors.lastname: Ie
authors.forename: L A
authors.initials: LA
authors.lastname: Yannuzzi
authors.forename: R F
authors.initials: RF
authors.lastname: Spaide
authors.forename: K P
authors.initials: KP
authors.lastname: Woodward
authors.forename: L J
authors.initials: LJ
authors.lastname: Singerman
authors.forename: M S
authors.initials: MS
authors.lastname: Blumenkranz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002829:Choroid / Q000098:blood supply; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D017075:Laser Coagulation; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000473:pathology; D010857:Pigment Epithelium of Eye / Q000473:pathology* / Q000601:surgery; D012163:Retinal Detachment / Q000473:pathology* / Q000601:surgery; D014792:Visual Acuity