title: A glove with exceptional protective features minimizes the risks of working with hazardous chemicals.
abstract: In continuation of our preceding studies, we disclose long-term experiments to test more extensively the protective power of the novel 4H Glove. 2 compounds encountered in modern electron microscopy technique, 1-hexadecene (1-HD) and 2-hydroxyethyl acrylate (2-HEA), which elicit allergic and/or toxic reactions in laboratory workers, were tested for their penetration through the 4H Glove material 1-HD has not to our knowledge been tested on any glove material. 2-HEA was known to have a breakthrough time exceeding 240 min; in contrast, it penetrates the common latex or vinyl gloves within minutes. When exposing the outside of a 4H Glove to 2-HEA for 200 h at 21 degrees C and then attaching the reverse unexposed side to a sensitized volunteer's forearm, 30 min of contact elicited a barely visible reddening of the skin at the contact site which disappeared within 24 h; 90 min of contact caused a somewhat stronger reddening limited to the contact area, which disappeared within 2 days. By the same criteria, 1-HD did not penetrate through the 4H Glove in 200 h. In an additional experiment, breakthrough time of 1-HD on latex gloves was less than 30 min.
authors.affiliation: Department of Internal Medicine, University Hospital Zürich, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Tobler
authors.forename: A U
authors.initials: AU
authors.lastname: Freiburghaus
mesh_terms: D000328:Adult; D000475:Alkenes / Q000009:adverse effects; D003877:Dermatitis, Contact / Q000209:etiology / Q000517:prevention & control*; D009783:Dermatitis, Occupational / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006229:Hand Dermatoses / Q000139:chemically induced / Q000517:prevention & control*; D006801:Humans; D007840:Latex; D010328:Patch Tests; D011102:Polyhydroxyethyl Methacrylate / Q000009:adverse effects / Q000031:analogs & derivatives; D011481:Protective Clothing; D012307:Risk Factors
chemical_list: D000475:Alkenes; D007840:Latex; D011102:Polyhydroxyethyl Methacrylate; C023037:poly(2-hydroxyethyl acrylate); C010734:cetene