title: Proliferation in non-Hodgkin's lymphomas as determined by immunohistochemical double staining for Ki-67.
abstract: The authors have studied proliferation (growth fractions) in non-Hodgkin's lymphomas (NHL) using an immunohistochemical double staining technique with the monoclonal antibody (MoAb), Ki-67, in order to clarify the relationships between histologic type, proliferation and prognosis. The percentages of Ki-67 positive (Ki-67+) cells in B cell lymphomas were higher for diffuse lymphomas than for follicular lymphomas and increased in order from small to large cell types. In addition, the percentage of Ki-67+ cells in B cell lymphomas inversely correlated with survival in months (n = 33 r = -0.54 p < 0.01). These results indicate that the percentage of Ki-67+ cells in B cell lymphomas correlates with histologic type and prognosis. Although the prognosis of T cell lymphomas is considered worse than that of B cell lymphomas, the percentage of Ki-67+ cells was lower, in general, in T cell lymphomas than in B cell lymphomas. These data indicate that proliferation in T cell lymphomas does not correlate with survival.
authors.affiliation: First Department of Pathology, Fukushima Medical College, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tominaga
authors.forename: Y
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Nozawa
authors.forename: M
authors.initials: M
authors.lastname: Abe
authors.forename: H
authors.initials: H
authors.lastname: Wakasa
mesh_terms: D002455:Cell Division; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D019394:Ki-67 Antigen; D016393:Lymphoma, B-Cell / Q000276:immunology / Q000401:mortality / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology* / Q000401:mortality / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000276:immunology / Q000401:mortality / Q000473:pathology; D009687:Nuclear Proteins / Q000032:analysis*; D011379:Prognosis
chemical_list: D019394:Ki-67 Antigen; D009687:Nuclear Proteins