Trisomy 8 in Philadelphia chromosome (Ph1)-negative cells in the course of Ph1-positive chronic myelocytic leukemia.
A female patient with chronic myelocytic leukemia (CML) in chronic phase after busulfan and interferon treatment had four different cell lines in her bone marrow. In addition to cells with a normal karyotype there were cells with the Philadelphia chromosome (Ph1), cells with trisomy 8 and Ph1, and cells with trisomy 8 as the sole anomaly.
Casali
M
M
Biologia Generale e Genetica Medica, Università di Pavia, Italy.
Truglio
F
F
Milone
G
G
Di Raimondo
F
F
Parrinello
G
G
Maserati
E
E
Pasquali
F
F
D000368:Aged; D002066:Busulfan / Q000627:therapeutic use; D002892:Chromosomes, Human, Pair 22; D002898:Chromosomes, Human, Pair 8; D002899:Chromosomes, Human, Pair 9; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000235:genetics*; D009030:Mosaicism; D011994:Recombinant Proteins; D014178:Translocation, Genetic; D014314:Trisomy
D007370:Interferon Type I; D011994:Recombinant Proteins; D002066:Busulfan