The activation of major histocompatibility complex class I genes by interferon regulatory factor-1 (IRF-1).
We have investigated the role of interferon regulatory factor-1 (IRF-1), an interferon-gamma (IFN-gamma) inducible transcriptional activator, on major histocompatibility complex (MHC) class I gene transcription. IRF-1 alone is sufficient to trans-activate both transfected and endogenous class I genes and the effect of IRF-1 appears to be direct and sequence-specific. These data suggest that IRF-1 is involved in the IFN-gamma mediated induction of MHC class I expression.
Chang
C H
CH
Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510.
Hammer
J
J
Loh
J E
JE
Fodor
W L
WL
Flavell
R A
RA
D001483:Base Sequence; D002460:Cell Line; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000502:physiology*; D005434:Flow Cytometry; D005786:Gene Expression Regulation; D005809:Genes, Regulator / Q000502:physiology; D006367:HeLa Cells; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis*; D006801:Humans; D050856:Interferon Regulatory Factor-1; D008969:Molecular Sequence Data; D010750:Phosphoproteins / Q000502:physiology*; D010957:Plasmids; D011401:Promoter Regions, Genetic / Q000502:physiology; D012313:RNA / Q000032:analysis; D015534:Trans-Activators / Q000502:physiology; D014158:Transcription, Genetic / Q000502:physiology; D015533:Transcriptional Activation; D014162:Transfection; D015854:Up-Regulation / Q000502:physiology
D004268:DNA-Binding Proteins; D015395:Histocompatibility Antigens Class I; C494257:IRF1 protein, human; D050856:Interferon Regulatory Factor-1; D010750:Phosphoproteins; D015534:Trans-Activators; D012313:RNA