Phenytoin-induced IgG2 and IgG4 deficiencies in a patient with epilepsy.
A five-year-old girl with epilepsy and recurrent respiratory infections was investigated for serum IgG subclass concentrations. She was diagnosed as having a combined deficiency of IgG2 and IgG4 with a decreased serum concentration of IgA and IgG3 and was given replacement therapy with i.v. immunoglobulins. Since then, she has been free from respiratory infections. After phenytoin therapy was stopped, IgG subclass deficiency improved. This case describes the further action of phenytoin on the immune system, adding IgG subclass deficiency to the list.
Ishizaka
A
A
Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan.
Nakanishi
M
M
Kasahara
E
E
Mizutani
K
K
Sakiyama
Y
Y
Matsumoto
S
S
D002675:Child, Preschool; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D006801:Humans; D017099:IgG Deficiency / Q000139:chemically induced* / Q000276:immunology / Q000628:therapy; D007136:Immunoglobulins / Q000097:blood; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D010672:Phenytoin / Q000009:adverse effects* / Q000627:therapeutic use
D007136:Immunoglobulins; D016756:Immunoglobulins, Intravenous; D010672:Phenytoin