Ph-positive chronic myeloid leukemia with loss of the segment distal to M-bcr.
We describe a patient with chronic myeloid leukemia (CML) and a 22q- but no 9q+ chromosome. Southern blot analysis showed a BCR rearrangement. The patient soon developed profound and superficial thrombophlebitis in arms and legs and died from pulmonary embolisation 15 days after diagnosis. Five CML cases with a deletion of 22q but no known translocation of 22q11----qter have been described earlier. The present patient is the first such case, however, in whom a BCR rearrangement has been demonstrated.
Pedersen
B
B
Department of Cytogenetics, Danish Cancer Society, Aarhus.
Bartram
C R
CR
Nielsen
J L
JL
D001752:Blast Crisis / Q000235:genetics / Q000473:pathology; D001943:Breast Neoplasms; D002277:Carcinoma; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002899:Chromosomes, Human, Pair 9; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D015321:Gene Rearrangement; D016313:Genes, abl; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D009857:Oncogenes; D010677:Philadelphia Chromosome
D016044:Fusion Proteins, bcr-abl