Human T-cell activation deficiencies.
The increasing understanding of T-cell activation is paralleled by the recognition of a growing range of 'experiments of nature' that cause T-cell activation deficiencies. Analysis of these deficiencies is, in turn, contributing to the understanding of T-cell function in vivo. Here, José Regueiro, Antonio Arnaiz-Villena and colleagues review current knowledge of structural and functional T-cell defects and the implications of these for T-cell biology.
Arnaiz-Villena
A
A
Dept of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain.
Timón
M
M
Rodríguez-Gallego
C
C
Pérez-Blas
M
M
Corell
A
A
Martín-Villa
J M
JM
Regueiro
J R
JR
D000243:Adenosine Deaminase / Q000172:deficiency; D000938:Antigen-Presenting Cells / Q000276:immunology; D015703:Antigens, CD / Q000502:physiology; D002448:Cell Adhesion; D002648:Child; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D008213:Lymphocyte Activation / Q000187:drug effects; D008954:Models, Biological; D011683:Purine-Nucleoside Phosphorylase / Q000172:deficiency; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology*
D015703:Antigens, CD; D011948:Receptors, Antigen, T-Cell; D011683:Purine-Nucleoside Phosphorylase; D000243:Adenosine Deaminase