Ti gamma A + delta TCS1+ T cells in human thymus. Analysis of the T cell receptor.
TcR1+ T cells in peripheral blood have been shown to express in an exclusive fashion either the Ti gamma A or the delta TCS1 epitope. Here, we characterize a subset of TcR1+ T cells in fresh thymus co-expressing the Ti gamma A and delta TCS1 epitopes. TcR1dim and TcR1bright clones can be distinguished. Biochemical and molecular studies on both types of clones generated from these thymocytes reveal a unique T cell receptor structure characterized by the use of a V gamma 9/C gamma 2-encoded 55-kDa gamma chain nondisulfide linked to a V delta 1-encoded delta chain.
Bosse
R
R
Abteilung Immunologie und Transfusionsmedizin, Medizinische Hochschule, Hannover, FRG.
Heiken
H
H
Kolanus
W
W
Delany
P
P
Triebel
F
F
Schmidt
R E
RE
D002460:Cell Line; D004220:Disulfides / Q000032:analysis; D006801:Humans; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology*
D004220:Disulfides; D016692:Receptors, Antigen, T-Cell, gamma-delta