Ion channels in action potential generation.
Molecular structure-function studies have identified the two key regions--the voltage sensor and pore--of the sodium and potassium channels responsible for the action potential in nerve axon. Mutational analysis has focused on the amino acids that are most important in each region. Similar studies in myocytes and nerve cell bodies are now being pursued.
Brown
A M
AM
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston.
D000200:Action Potentials / Q000502:physiology; D000596:Amino Acids / Q000502:physiology; D000818:Animals; D001369:Axons / Q000502:physiology; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology; D007473:Ion Channels / Q000502:physiology*; D016062:Porosity; D015221:Potassium Channels / Q000502:physiology; D015222:Sodium Channels / Q000502:physiology
D000596:Amino Acids; D007473:Ion Channels; D015221:Potassium Channels; D015222:Sodium Channels