title: BUN/Cr ratio as an index of gastrointestinal bleeding mass in children.
abstract: Determining the site and severity of blood loss is important in the management of children with gastrointestinal (GI) bleeding. Blood urea nitrogen (BUN) and serum creatinine (Cr) were measured on the day of hospitalization and the ratio of BUN/Cr was calculated in 11 children with 16 episodes of upper GI bleeding and 49 with lower GI bleeding. There was a significant difference between the two GI bleeding groups with regard to BUN/Cr ratio (p less than 0.001). When the ratio was 30 or above, the specificity of upper GI bleeding was 98% with a sensitivity of 68.8%. A linear relationship was found between the BUN/Cr ratio and delta Hb (delta Hb = 0.08 x BUN/Cr +/- 0.8 g/dl) for bleeding originating from the upper GI tract. This study confirms that measurement of the BUN/Cr ratio is useful for localizing the source of bleeding to the upper GI tract and also demonstrates its usefulness as an estimation of the severity of blood loss from the upper GI tract.
authors.affiliation: Department of Pediatrics, Tokyo Jikei University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Urashima
authors.forename: S
authors.initials: S
authors.lastname: Toyoda
authors.forename: T
authors.initials: T
authors.lastname: Nakano
authors.forename: S
authors.initials: S
authors.lastname: Matsuda
authors.forename: N
authors.initials: N
authors.lastname: Kobayashi
authors.forename: H
authors.initials: H
authors.lastname: Kitajima
authors.forename: A
authors.initials: A
authors.lastname: Tokushige
authors.forename: H
authors.initials: H
authors.lastname: Horita
authors.forename: J
authors.initials: J
authors.lastname: Akatsuka
authors.forename: K
authors.initials: K
authors.lastname: Maekawa
mesh_terms: D000293:Adolescent; D001806:Blood Urea Nitrogen; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood*; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn
chemical_list: D003404:Creatinine