Resistance to collagen-induced arthritis in Biozzi mice is not associated with a defect in autoantibodies to accessible epitopes on cartilage collagen.
In order to understand why most strains of Biozzi mice are unexpectedly either arthritis-resistant, or susceptible, we investigate the autoantibody reactivity against matrix-embedded collagen molecules. We show a close correlation between these tissular and the free collagen antibodies, irrespective of arthritis susceptibility. These results are against an antibody response restricted to hidden non-pathogenic epitopes in the resistant mice.
Bouvet
J P
JP
Unité d'Immunologie Microbienne, Institut Pasteur, Paris, France.
Franc
B
B
Zyad
A
A
Couderc
J
J
D000818:Animals; D001169:Arthritis, Experimental / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D002356:Cartilage / Q000276:immunology*; D003094:Collagen / Q000276:immunology*; D004198:Disease Susceptibility / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000276:immunology*; D007124:Immunoenzyme Techniques; D051379:Mice
D001323:Autoantibodies; D000939:Epitopes; D003094:Collagen