title: [The status of biological risk factors and the optimality concept in diagnosis of early childhood developmental disorders].
abstract: In a prospective study the psychomotor development up to the end of the second year of life of 409 preterm and term newborn infants was examined in order to identify which optimality score might be associated with disturbances of normal childlike development. Significant connections between 24 and 55 risk factors and the mortality could be demonstrated, but only 3 factors (sex, apgar, acidosis) exert influence on psychomotor development. The risk loading of the collective was high, not one of the children showed an optimal score. Decreased patients possessed a stronger reduced optimality than survivors. The optimality concept is not suitable for the prediction of later disturbed development of children, because the items are unspecific. The marker of hypoxia, the erythrocytic-density-test, as well as the neuron-specific enolase showed better diagnostic values than the optimality concept.
authors.affiliation: Frühgeborenenzentrum, Medizinischen Akademie Magdeburg.
authors.forename: H T
authors.initials: HT
authors.lastname: Abel
authors.forename: C
authors.initials: C
authors.lastname: Korb
authors.forename: S
authors.initials: S
authors.lastname: Meder
authors.forename: W
authors.initials: W
authors.lastname: Lamme
authors.forename: H
authors.initials: H
authors.lastname: Köditz
mesh_terms: D001925:Brain Damage, Chronic / Q000209:etiology* / Q000517:prevention & control; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000209:etiology* / Q000517:prevention & control; D006233:Persons with Disabilities; D004909:Erythrocyte Indices; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009460:Neurologic Examination; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D011446:Prospective Studies; D011596:Psychomotor Disorders / Q000209:etiology* / Q000517:prevention & control; D012307:Risk Factors
chemical_list: D010751:Phosphopyruvate Hydratase