Fonsecaea pedrosoi: lipid composition and determination of susceptibility to amphotericin B.
Conidia and mycelial cells of Fonsecaea pedrosoi ATCC 46428 were obtained for analyses of lipid composition. Total lipids, phospholipids, sterols, and qualitative sterols and fatty acid composition were determined. A higher lipid content was detected in conidia than in mycelial cells of Fonsecaea pedrosoi, which could not be attributed to total sterols and phospholipids. In both forms of this fungus, ergosterol was the only sterol detected. The minimal inhibitory concentration of amphotericin B was lower for conidia than for mycelium.
Gomes
M H
MH
Departamento de Microbiologia, Instituto de Ciências Biológicas Universidade Federal de Minas Gerais, Brazil.
Resende
M A
MA
D000666:Amphotericin B / Q000494:pharmacology*; D003881:Dermatomycoses / Q000188:drug therapy; D004352:Drug Resistance, Microbial; D004875:Ergosterol / Q000032:analysis; D006801:Humans; D008055:Lipids / Q000032:analysis*; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000737:chemistry / Q000187:drug effects* / Q000254:growth & development
D008055:Lipids; D000666:Amphotericin B; D004875:Ergosterol