title: Synteny mapping in the bovine: genes from human chromosome 5.
abstract: In an effort to generate a more complete bovine syntenic map of Type I comparative anchor loci, seven homologs to genes found on HSA5 were mapped using a panel of bovine x rodent hybrid somatic cells. Five HSA5 genes, CSF2, RPS14, PDGFRB, FGFA, and CSF1R, were assigned to bovine syntenic group U22 (chromosome 7), while two others, C9 and HGMCR, mapped to U10 and U5, respectively. Previous studies had assigned the HSA5 marker SPARC to bovine syntenic group U22. The mapping of genes spanning the length of HSA5 in cattle and also in mouse permits syntenic comparisons between prototypic genomes of three mammalian orders, providing insight into the evolutionary history of this region of the ancestral mammalian genome.
authors.affiliation: Department of Veterinary Pathobiology, Texas A & M University, College Station 77843.
authors.forename: N
authors.initials: N
authors.lastname: Zhang
authors.forename: J E
authors.initials: JE
authors.lastname: Womack
mesh_terms: D000214:Acyl Coenzyme A / Q000235:genetics; D000818:Animals; D015139:Blotting, Southern; D002417:Cattle / Q000235:genetics*; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5; D003115:Colony-Stimulating Factors / Q000235:genetics; D003186:Complement C9 / Q000235:genetics; D006224:Cricetinae; D004247:DNA / Q000032:analysis; D015342:DNA Probes; D016220:Fibroblast Growth Factor 1 / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D010982:Platelet-Derived Growth Factor / Q000235:genetics; D016184:Receptors, Colony-Stimulating Factor / Q000235:genetics; D012269:Ribosomal Proteins / Q000235:genetics
chemical_list: D000214:Acyl Coenzyme A; D003115:Colony-Stimulating Factors; D003186:Complement C9; D015342:DNA Probes; D010982:Platelet-Derived Growth Factor; D016184:Receptors, Colony-Stimulating Factor; D012269:Ribosomal Proteins; C039747:ribosomal protein S14; D016220:Fibroblast Growth Factor 1; C008047:3-hydroxy-3-methylglutaryl-coenzyme A; D004247:DNA