title: Normothermic arrest with continuous hyperkalaemic blood: initial experience.
abstract: The requirement for hypothermia in myocardial protection has recently been questioned. Between October 1990 and May 1991, diastolic arrest was achieved using continuous perfusion with normothermic, hyperkalaemic blood in 257 consecutive patients undergoing cardiac surgery. The mean age was 59.8 +/- 9.3 years (range 28-84 years). Coronary artery surgery was performed in 210 patients, valve replacements in 18, combined procedures in 22, and 7 patients had miscellaneous procedures. Eleven patients (4.3%) had undergone previous cardiac surgery, and 65 (25.3%) required urgent or emergency operations. Hyperkalaemic blood (7-20 mmol/l) was delivered antegradely in 190 (72.8%) patients (mean aortic root pressure 60-80 mmHg), retrogradely in 62 (25.3%) patients (mean coronary sinus pressure less than 40 mmHg), and by a combined route in 5 (1.9%). Sinus rhythm returned immediately after removal of the aortic clamp in 235 (91.4%) patients. Weaning from bypass was achieved without circulatory support in 207 (82.5%) patients. Of 233 patients undergoing non-emergency coronary artery surgery, single valve or combined procedures, 11 died, giving an operative mortality of 4.7%. Of 155 patients with good left ventricular function requiring coronary artery surgery, 3 (1.9%) died. The in-hospital mortality for the group as a whole was 7.3%. Sixteen (6.2%) patients sustained perioperative myocardial infarctions; of these 6 died. We conclude that continuous, normothermic, hyperkalaemic arrest is a simple and safe method of myocardial protection. It may avoid the damage associated with hypothermia, ischaemia and reperfusion.
authors.affiliation: Cardiothoracic Centre, Liverpool, UK.
authors.forename: R D
authors.initials: RD
authors.lastname: Page
authors.forename: D A
authors.initials: DA
authors.lastname: Sharpe
authors.forename: C M
authors.initials: CM
authors.lastname: Bellamy
authors.forename: A
authors.initials: A
authors.lastname: Rashid
authors.forename: B M
authors.initials: BM
authors.lastname: Fabri
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001243:Assisted Circulation; D001831:Body Temperature; D002118:Calcium / Q000097:blood*; D006348:Cardiac Surgical Procedures / Q000379:methods / Q000401:mortality; D002315:Cardiopulmonary Bypass; D005260:Female; D006324:Heart Arrest, Induced / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications
chemical_list: D002118:Calcium