title: Lymphocytic adenohypophysitis with sudden onset of diabetes insipidus in menopausal female--case report.
abstract: A rare case of a postmenopausal (60-year-old) female with lymphocytic adenohypophysitis manifesting as a sudden onset of diabetes insipidus is reported. Magnetic resonance imaging with gadolinium-diethylene-triaminepentaacetic acid enhancement showed a spherical lesion, approximately 1 cm in diameter, in the sella turcica and a thickened, deviated pituitary stalk. The abnormal tissue was totally removed. Histological examination showed marked infiltration of lymphocytes and plasma cells. Postoperatively, the pituitary stalk became normal. Preoperative differentiation of lymphocytic adenohypophysitis from pituitary adenoma is extremely difficult, and biopsy is essential.
authors.affiliation: Department of Neurosurgery, University of the Ryukyus School of Medicine, Okinawa.
authors.forename: K
authors.initials: K
authors.lastname: Ito
authors.forename: J
authors.initials: J
authors.lastname: Mukawa
authors.forename: K
authors.initials: K
authors.lastname: Miyagi
authors.forename: E
authors.initials: E
authors.lastname: Takara
authors.forename: S
authors.initials: S
authors.lastname: Mekaru
authors.forename: Y
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Higa
mesh_terms: D000236:Adenoma / Q000175:diagnosis; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000473:pathology; D001706:Biopsy; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D003919:Diabetes Insipidus / Q000188:drug therapy / Q000209:etiology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008593:Menopause; D008875:Middle Aged; D010900:Pituitary Diseases / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D010903:Pituitary Gland, Anterior / Q000473:pathology; D010911:Pituitary Neoplasms / Q000175:diagnosis; D010950:Plasma Cells / Q000473:pathology
chemical_list: D003894:Deamino Arginine Vasopressin