Voltammetric study of 8-OH-DPAT effect on the raphe-trigeminal 5-HT system.
The effect of i.p. administration of the selective 5-HT1A agonist 8-hydroxy-2-(di-N-propylamino) tetralin (8-OH-DPAT) (100 micrograms kg-1) has been investigated by in vivo 5-hydroxyindole electrochemical (peak 3) detection in the nucleus raphe magnus (NRM) and medullary dorsal horn (MDH) of acute anaesthetized and unanaesthetized freely moving rats. 8-OH-DPAT induced a small but significant decrease in peak 3 in the NRM and MDH of anaesthetized rats. In freely moving animals, a similar small effect was observed at both NRM and MDH levels. With reference to similar in vivo studies demonstrating differential responsiveness of ascending serotonergic systems to 8-OH-DPAT, it is concluded that the serotonergic NRM-dorsal horn system is slightly affected by this 5-HT1A agonist.
Puig
S
S
Unité de Recherches de Physiopharmacologie du Système Nerveux (INSERM U 161), Paris, France.
Rivot
J P
JP
Besson
J M
JM
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000633:toxicity*; D000704:Analysis of Variance; D000818:Animals; D004594:Electrophysiology / Q000379:methods; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects / Q000502:physiology*; D011903:Raphe Nuclei / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D012701:Serotonin / Q000378:metabolism*; D014278:Trigeminal Nuclei / Q000187:drug effects / Q000502:physiology*
D011985:Receptors, Serotonin; D012701:Serotonin; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin