The anticoagulant effects of ionic and nonionic low-osmolar contrast media in dogs.
OBJECTIVE
The anticoagulant effects of ionic and nonionic low-osmolar contrast media were evaluated in vivo.


METHODS
The amount of clot deposited on guide wires placed in the femoral vessels of dogs was weighed 30 minutes after the injection of 2 mL/kg of different contrast media. Six dogs were examined after injection of ioxaglate (ioxaglate group), six after injection of iopamidol (iopamidol group), and five after injection of saline (saline group).


RESULTS
The mean weights of clot deposited on the guide wires in dogs in the ioxaglate group, the iopamidol group, and saline group were 30.5, 63.1, and 74.2 mg, respectively. The mean weight of clot deposition on the guide wires in the ioxaglate group was significantly less than in the iopamidol and saline groups, whereas there was no statistical difference in the mean weight of clot deposition on the guide wires in the iopamidol and saline groups.


CONCLUSIONS
Ioxaglate, a low-osmolar, ionic contrast medium, has a greater anticoagulant effect than a low-osmolar, nonionic contrast agent, such as iopamidol.
Kurisu
Y
Y
Department of Radiology, Jikei University School of Medicine, Tokyo, Japan.
Tada
S
S
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D003287:Contrast Media / Q000494:pharmacology*; D004285:Dogs; D007479:Iopamidol / Q000494:pharmacology; D007485:Ioxaglic Acid / Q000494:pharmacology; D009994:Osmolar Concentration
D000925:Anticoagulants; D003287:Contrast Media; D007479:Iopamidol; D007485:Ioxaglic Acid