Isometachromin, a new cytotoxic sesquiterpenoid from a deep water sponge of the family Spongiidae.
Isometachromin (1), a new sesquiterpene-quinone that is related structurally to metachromin C (2), and the known compounds ilimaquinone (3) and 5-epi-ilimaquinone (4), were isolated from a deep water sponge in the family Spongiidae; the structure of isometachromin was elucidated by spectral methods. Isometachromin exhibits in vitro cytotoxicity against the human lung cancer cell line A549 (IC50 = 2.6 micrograms/ml), but not against P388 murine leukemia (IC 50 > or equal to 10 micrograms/ml) and also exhibits antimicrobial activity.
McConnell
O J
OJ
Harbor Branch Oceanographic Institution, Inc., Ft. Pierce, FL 34946.
Longley
R
R
Gunasekera
M
M
D000818:Animals; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D011161:Porifera / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
D003603:Cytotoxins; D012717:Sesquiterpenes; C077213:isometachromin