Oral acitretin induces alterations in mouse liver phospholipid composition.
3 and 10 mg/kg/day acitretin, a new synthetic retinoid, were orally administered to two groups of Ng57Bln mice (12 animals each) respectively, over a period of six weeks. Control animals (N = 10) received corresponding quantities of arachis oil. Chromatographic analysis and quantitative determination of the isolated phospholipid classes revealed statistically significant alterations in the liver phospholipid composition of the treated animals under both acitretin dosages, which may be associated with changes in the metabolic activity, ionic transport and cell-cell interaction of the liver cellular components.
Tsambaos
D
D
Department of Dermatology, University of Patras, Rio-Patras, Greece.
Kalofoutis
A
A
Georgiou
S
S
Koulocheris
A
A
D017255:Acitretin; D000284:Administration, Oral; D000818:Animals; D005260:Female; D008099:Liver / Q000187:drug effects*; D051379:Mice; D008812:Mice, Hairless; D010713:Phosphatidylcholines / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D014212:Tretinoin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
D010713:Phosphatidylcholines; D010743:Phospholipids; D014212:Tretinoin; D017255:Acitretin