Effect of gamma interferon on resolution of murine chlamydial genital infection.
Mice infected in the genital tract with the Chlamydia trachomatis agent of mouse pneumonitis were treated with monoclonal rat anti-gamma interferon (anti-IFN-gamma) antibody to determine whether IFN-gamma participated in the resolution of the infection. In two experiments, anti-IFN-gamma antibody treatment resulted in significantly prolonged infections. In support of these data, passive administration of recombinant IFN-gamma to chronically infected nu/nu mice was able to bring about resolution of the infection in some animals.
Rank
R G
RG
Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock 72205.
Ramsey
K H
KH
Pack
E A
EA
Williams
D M
DM
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D002690:Chlamydia Infections / Q000276:immunology*; D002692:Chlamydia trachomatis; D005260:Female; D005831:Genital Diseases, Female / Q000276:immunology*; D007371:Interferon-gamma / Q000494:pharmacology / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D011994:Recombinant Proteins
D000911:Antibodies, Monoclonal; D011994:Recombinant Proteins; D007371:Interferon-gamma