Electrophysiological findings in a case of severe intrathecal baclofen overdose.
Multimodality evoked potentials were examined in a case of serious accidental intrathecal baclofen overdose in a patient who suffered from severe spasticity due to a traumatic brain lesion. Electrophysiological findings during, before and after the intoxication were compared. Transcranial electrical stimulation up to 750 V did not evoke any responses in thenar muscles on the first day of intoxication. An improvement to normal values was observed within 3 days, paralleled by an amelioration of the patient's clinical condition. Cervical electrical stimulation was largely unaffected by baclofen. Median nerve somatosensory and brain-stem acoustic evoked potentials revealed few or no differences during intoxication compared to pre- and post-intoxication responses.
Kofler
M
M
Department of Neurology, Innsbruck University, Austria.
Saltuari
L
L
Schmutzhard
E
E
Berek
K
K
Baumgartner
H
H
Russegger
L
L
Aichner
F
F
D000293:Adolescent; D001418:Baclofen / Q000506:poisoning*; D062787:Drug Overdose / Q000503:physiopathology; D004558:Electric Stimulation; D004569:Electroencephalography / Q000187:drug effects; D005071:Evoked Potentials / Q000187:drug effects; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D009132:Muscles / Q000502:physiology; D011930:Reaction Time / Q000187:drug effects
D001418:Baclofen