[Specificity of the effect of polyene phosphatidylcholine depending on the mode of administration and animal species].
The effects of polyene phosphatidylcholine (PPC) treatment at oral and intravenous administration to rats and rabbits in hypercholesterolemic diet were studied. No aorta damage was observed in either of rat groups. But fatty liver appeared, and it was the greatest in rats, who received cholesterol and PPC. The result may be attributed to adaptive protection of peripheral tissues due to high experiment duration (18 months) in the state of active reverse cholesterol transport (RChT). No antiatherogenic effect was noted in rabbits at PPC administration (170 mg/kg), while its intravenous injection (50 mg/kg) resulted in marked reduction of plasma cholesterol level, elevation of HDL cholesterol and decrease of the extent of aorta damage. The conclusion is drawn on the ppc high antiatherogenic effect predominantly at intravenous administration, and on advisability of its use in cases of RChT deficiencies, as its activator.
Tarkhovskaia
T I
TI
Khalilov
E M
EM
Fortinskaia
E S
ES
Kliuchnikova
Zh I
ZhI
Rikhter
F
F
Morvinski
I
I
Kliaĭn
K
K
Rassul
F
F
Kiunnert
V
V
Rotch
V
V
D000284:Administration, Oral; D000818:Animals; D001161:Arteriosclerosis / Q000097:blood / Q000188:drug therapy / Q000378:metabolism; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D004036:Diet, Atherogenic; D007275:Injections, Intravenous; D008074:Lipoproteins / Q000097:blood; D010713:Phosphatidylcholines / Q000008:administration & dosage* / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity; D014280:Triglycerides / Q000097:blood
D008074:Lipoproteins; D010713:Phosphatidylcholines; D014280:Triglycerides; C029449:polyene phosphatidylcholine; D002784:Cholesterol