title: dup(12)(q13----qter) in two t(14;18)-negative follicular B-non-Hodgkin's lymphomas.
abstract: Two t(14;18)-negative follicular B-non-Hodgkin's lymphomas with the same chromosomal abnormality, dup(12)(q13----qter), are presented. The absence of a BCL2 gene rearrangement was confirmed by molecular studies in both cases. Instead, duplication of a 12q segment was found. Further evidence for the presence of the dup(12)(q13----qter) was found using fluorescence in situ hybridization. dup(12q) may be equivalent to the trisomy 12 originally described in B-chronic lymphocytic leukemia. This chromosome anomaly has also been reported in B-non-Hodgkin's lymphomas, usually in association with other chromosome anomalies and a more aggressive tumor phenotype. Occurrence of dup(12q) in two histologically similar cases of follicular small cleaved-cell lymphoma without a typical t(14;18), suggests that this karyotypic change may play a critical role in some cases of follicle center-cell lymphomas.
authors.affiliation: Center for Human Genetics, University of Leuven, Belgium.
authors.forename: I
authors.initials: I
authors.lastname: Wlodarska
authors.forename: C
authors.initials: C
authors.lastname: Mecucci
authors.forename: E
authors.initials: E
authors.lastname: Vandenberghe
authors.forename: C
authors.initials: C
authors.lastname: De Wolf-Peeters
authors.forename: J
authors.initials: J
authors.lastname: Thomas
authors.forename: C
authors.initials: C
authors.lastname: Hilliker
authors.forename: E
authors.initials: E
authors.lastname: Schoenmakers
authors.forename: M
authors.initials: M
authors.lastname: Stul
authors.forename: P
authors.initials: P
authors.lastname: Marynen
authors.forename: J J
authors.initials: JJ
authors.lastname: Cassiman
mesh_terms: D000368:Aged; D002869:Chromosome Aberrations; D002881:Chromosomes, Human, Pair 12; D002883:Chromosomes, Human, Pair 14; D002887:Chromosomes, Human, Pair 18; D015342:DNA Probes / Q000235:genetics; D005260:Female; D005453:Fluorescence; D006801:Humans; D016393:Lymphoma, B-Cell / Q000235:genetics*; D008224:Lymphoma, Follicular / Q000235:genetics*; D009693:Nucleic Acid Hybridization
chemical_list: D015342:DNA Probes