title: [Fatal course of peracute fatty liver of pregnancy].
abstract: A fatal case of acute fatty liver of pregnancy (AFLP) is reported. After admission, the patient was delivered within 3 hours. Routine laboratory investigation revealed acute liver insufficiency with advanced coagulopathy. Despite substitution therapy, the severe coagulation defect progressed to lethal intracerebral bleeding. Advanced AFLP can only be satisfactorily diagnosed in time, if non-specific symptoms or icterus lead to studies of blood chemistry, especially liver function tests, coagulation parameters (including platelet count, fibrinogen, AT III), blood glucose and renal function (including uric acid). This will enable an adequate management of the patient. The clinical problem of AFLP still remains that of early diagnosis.
authors.affiliation: Universitätsfrauenklinik Tübingen.
authors.forename: J
authors.initials: J
authors.lastname: Fischer
authors.forename: C
authors.initials: C
authors.lastname: Rozenbajgier
authors.forename: M
authors.initials: M
authors.lastname: Schulze
authors.forename: K
authors.initials: K
authors.lastname: Decker
authors.forename: P
authors.initials: P
authors.lastname: Stoll
mesh_terms: D000208:Acute Disease; D000328:Adult; D003937:Diagnosis, Differential; D005234:Fatty Liver / Q000473:pathology*; D005260:Female; D017359:HELLP Syndrome / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008099:Liver / Q000473:pathology; D008297:Male; D007744:Obstetric Labor Complications / Q000473:pathology*; D006473:Postpartum Hemorrhage / Q000473:pathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000473:pathology*; D011272:Pregnancy, Multiple / Q000502:physiology*; D014593:Uterine Inertia / Q000473:pathology*