Ciwujianosides D1 and C1: powerful inhibitors of histamine release induced by anti-immunoglobulin E from rat peritoneal mast cells.
In rat peritoneal mast cells induced by anti-immunoglobulin E, ciwujianosides D1 (1) and C1 (2) from Acanthopanax senticosus (ciwujia) strongly inhibited histamine release in a concentration-dependent manner. The inhibitory effect of 1 was approximately 6800 times stronger than that of disodium cromoglycate.
Umeyama
A
A
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Shoji
N
N
Takei
M
M
Endo
K
K
Arihara
S
S
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D002478:Cells, Cultured; D006636:Histamine Release / Q000187:drug effects*; D007073:Immunoglobulin E / Q000276:immunology*; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism*; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D010529:Peritoneal Cavity / Q000166:cytology; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000494:pharmacology*
D000888:Antibodies, Anti-Idiotypic; D010936:Plant Extracts; D012503:Saponins; C077203:ciwujianoside C1; C077202:ciwujianoside D1; D007073:Immunoglobulin E; D009828:Oleanolic Acid