title: Seasonal variation of prostatic acid phosphate and prostate-specific antigen in patients without prostatic malignancy.
abstract: The seasonal pattern of prostatic acid phosphatase (PAP) and prostate specific antigen (PSA) in nonmalignant males was investigated. Serum levels were measured in 1,540 men during a 3-year period with radioimmunoassay methods using monoclonal antibody techniques. All of the tested individuals were free of prostatic malignancy. During each of the 3 years, PAP ans PSA showed a rise, especially in spring. The mean PSA level in spring showed a statistically important difference when compared with winter, fall and summer mean levels (p less than 0.05). However, no significant difference of PAP levels was estimated seasonally in the 3 years, which shows that an important marker of prostatic cancer can vary with seasons.
authors.affiliation: Department of Urology, Uludağ University, Bursa, Turkey.
authors.forename: U
authors.initials: U
authors.lastname: Simşek
authors.forename: S
authors.initials: S
authors.lastname: Kutlu
authors.forename: I
authors.initials: I
authors.lastname: Yavaşçaouğlu
authors.forename: B
authors.initials: B
authors.lastname: Oktay
authors.forename: M
authors.initials: M
authors.lastname: Ozyurt
mesh_terms: D000135:Acid Phosphatase / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D011470:Prostatic Hyperplasia / Q000097:blood*; D012621:Seasons
chemical_list: D014408:Biomarkers, Tumor; D000135:Acid Phosphatase; D017430:Prostate-Specific Antigen