title: [Clinical studies on pediatric purulent meningitis--statistical analysis of etiology and therapy].
abstract: In a total of 149 children with purulent meningitis we encountered in our institute in the last 20 years, the causatives, the changes in therapeutic management and the prognosis were investigated. The causatives could be detected in 109 patients (73%): H. influenzae; 30 patients (20%), S. pneumoniae; 18 patients (12%), E. coli; 13 patients (9%), GBS; 7 patients (5%) and S. aureus; 6 patients (4%). These five causatives were detected in 49% of the total patients, or 67% of the patients in whom causatives could be detected. Of these five causatives, E. coli were detected the most frequently in the first half of 1970's, but, in recent years, the detection of GBS, S. pneumoniae and H. influenzae has been remarkably increasing. In spite of progress in antibiotics, the prognosis of the disease due to S. pneumoniae, GBS and S. aureus was poor. In the majority of the patients who died, the death came within five days after hospitalization due to loss of consciousness, convulsion etc. It is therefore necessary not only to initiate strong antibiotic treatment as soon as possible after early diagnosis, but also to take symptomatic measures such as steroidal treatment, treatment of shock etc.
authors.affiliation: Department of Pediatrics, Tokyo Jikei University School of Medicine.
authors.forename: K
authors.initials: K
authors.lastname: Fukunaga
authors.forename: C
authors.initials: C
authors.lastname: Nishimura
authors.forename: H
authors.initials: H
authors.lastname: Tamaki
authors.forename: Y
authors.initials: Y
authors.lastname: Saito
authors.forename: M
authors.initials: M
authors.lastname: Okazaki
authors.forename: Y
authors.initials: Y
authors.lastname: Wada
authors.forename: S
authors.initials: S
authors.lastname: Kobayashi
authors.forename: N
authors.initials: N
authors.lastname: Wada
authors.forename: F
authors.initials: F
authors.lastname: Ito
authors.forename: M
authors.initials: M
authors.lastname: Kubo
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D016920:Meningitis, Bacterial / Q000188:drug therapy / Q000382:microbiology* / Q000401:mortality; D008583:Meningitis, Haemophilus / Q000382:microbiology; D008586:Meningitis, Pneumococcal / Q000382:microbiology; D011379:Prognosis
chemical_list: D000900:Anti-Bacterial Agents