title: Interleukin-5 in eosinophilic gastroenteritis.
abstract: During a 4-year period a 28-year-old female had 4 episodes of eosinophilia of over 10,000/mu 1; these episodes were associated with nausea, vomiting, diarrhea, and abdominal pain. On one occasion, she had ascites and pleural effusion which contained numerous mature eosinophils. On each occasion, these attacks disappeared within several weeks without any specific treatment. A diagnosis of eosinophilic gastroenteritis was made. A plasma sample obtained during the eosinophilia generated in vitro eosinophilic colonies when added to granulocyte/macrophage-progenitor (CFU-GM) cultures without exogenous growth factors. Colony formation was inhibited by anti-interleukin-5 (IL-5) antibody but not by antibodies toward IL-3, granulocyte colony-stimulating factor (G-CSF) or GM-CSF. A high plasma interleukin-5 (IL-5) level was noted when measured by enzyme-linked immunosorbent assay, while IL-3, G-CSF, and GM-CSF were undetectable. During remission the plasma gave negative results both for colony formation and IL-5 level. These results indicate that the eosinophilia of this disease is mediated by IL-5.
authors.affiliation: Second Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
authors.forename: S
authors.initials: S
authors.lastname: Nishikawa
authors.forename: R
authors.initials: R
authors.lastname: Tsuyuoka
authors.forename: A
authors.initials: A
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Murakami
authors.forename: M
authors.initials: M
authors.lastname: Amenomori
authors.forename: Y
authors.initials: Y
authors.lastname: Okuno
authors.forename: H
authors.initials: H
authors.lastname: Imura
mesh_terms: D000328:Adult; D000906:Antibodies / Q000032:analysis / Q000276:immunology; D001853:Bone Marrow / Q000378:metabolism; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D004797:Enzyme-Linked Immunosorbent Assay; D004802:Eosinophilia / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D005260:Female; D005759:Gastroenteritis / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D016179:Granulocyte Colony-Stimulating Factor / Q000032:analysis / Q000276:immunology; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000032:analysis / Q000276:immunology; D006801:Humans; D007377:Interleukin-3 / Q000032:analysis / Q000276:immunology; D015848:Interleukin-5 / Q000097:blood* / Q000378:metabolism / Q000502:physiology
chemical_list: D000906:Antibodies; D007377:Interleukin-3; D015848:Interleukin-5; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor