Selective localization of radioiodinated alkylphosphocholine derivatives in tumors.
We have designed and synthesized two radioiodinated analogs of hexadecylphosphocholine in order to evaluate their tumor imaging potential. 12-(m[125I]iodophenyl)dodecyl phosphocholine (NM-324) and hexadecyl-2-[N,N-dimethyl-N-(m[125I]iodobenzyl)-ammonium] ethyl phosphate (NM-326) demonstrated the ability of such compounds to localize in and thereby visualize the Walker 256 tumor in rats. However, the tumor avidity of NM-324 was far superior to NM-326. In addition, NM-324 showed excellent tumor localization in athymic mice bearing subcutaneous human tumors.
Plotzke
K P
KP
Department of Pharmacology, University of Michigan, Ann Arbor 48109.
Haradahira
T
T
Stancato
L
L
Olken
N M
NM
Skinner
S
S
Gross
M D
MD
Wahl
R L
RL
Counsell
R E
RE
D000818:Animals; D002279:Carcinoma 256, Walker / Q000000981:diagnostic imaging*; D005260:Female; D007457:Iodine Radioisotopes; D008099:Liver / Q000378:metabolism; D010742:Phospholipid Ethers / Q000138:chemical synthesis / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
D007457:Iodine Radioisotopes; D010742:Phospholipid Ethers; C077316:NM 326; C077315:NM 324