title: Effects of periodic backflushing on ultrafiltration performance.
abstract: Periodic backflushing was introduced to a membrane separation process to improve the performance. Hemoglobin (M.W. = 62,500) and dextran (M.W. = 10,000) were used as model compounds. Filtration performance of an ultrafiltration membrane system (Amicon hollow fiber membrane, H1P30-43, molecular weight cutoff = 30,000) was measured in terms of apparent permeability and retention coefficient of dextran to determine the effects of backflushing frequency and duration of one cycle. An optimum frequency around 0.2 min-1 existed to give a maximum permeability while the retention of dextran decreased with increasing frequencies. The improvement in permeability by periodic backflush was more than doubled. The retention of dextran decreased as backflushing duration was increased in one cycle. With the duration of 33.75 s, the retention of dextran was less than 50% and dextran output was 1.14 g/h, which was 1.3 times the value without backflushing. Also, periodic backflush made possible the long-term filtration of yeast cells for more than 20 h.
authors.affiliation: Bioprocess Engineering Research Center, Korea Advanced Institute of Science and Technology, Seoul.
authors.forename: B S
authors.initials: BS
authors.lastname: Kim
authors.forename: H N
authors.initials: HN
authors.lastname: Chang
mesh_terms: D003911:Dextrans / Q000302:isolation & purification; D006454:Hemoglobins / Q000302:isolation & purification; D014462:Ultrafiltration
chemical_list: D003911:Dextrans; D006454:Hemoglobins