title: [Acute hepatitis A (HA) presenting findings of meningoencephalitis].
abstract: A 39-year-old man, who had high grade fever and headache for 4 days was admitted to our hospital because of generalized seizure and disturbance of consciousness. He was pyrexial, but not icteric. Neurological examination revealed disorientation, nuchal rigidity and bilateral Babinski reflexes. Laboratory test results included the following: GOT 1,740 U/l, GPT 2,800 U/l, bilirubin 1.2 mg/dl, serum IgM-HA antibody cut-off index 6.8. CSF was clear, with 10 leukocytes/mm3 and protein level of 108 mg/dl. Head CT and MRI revealed no abnormality. An EEG demonstrated diffuse slowing. During the following 2 days, he had increased obtundation and labored breathing. In the second week of hospitalization his neurological conditions and liver function test results improved. A diagnosis of HA was confirmed by a finding of serum IgM-HA antibody. The neurological findings, CSF findings and clinical course indicated acute meningoencephalitis in association with HA. To our knowledge, there have been only 4 previous case reports of meningoencephalitis associated with serologically confirmed HA infection. HA virus infection might pass unnoticed, as many cases of HA infection remain anicteric or subclinical. Therefore, HA virus should also be considered as one of the etiological agents in meningoencephalitis.
authors.affiliation: Department of Neurology, Tokai University School of Medicine.
authors.forename: K
authors.initials: K
authors.lastname: Matsushima
authors.forename: K
authors.initials: K
authors.lastname: Niwa
authors.forename: H
authors.initials: H
authors.lastname: Fujita
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Shinohara
mesh_terms: D000208:Acute Disease; D000328:Adult; D006506:Hepatitis A / Q000150:complications* / Q000276:immunology; D006508:Hepatitis Antibodies / Q000032:analysis; D006518:Hepatitis Viruses / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008590:Meningoencephalitis / Q000209:etiology* / Q000276:immunology
chemical_list: D006508:Hepatitis Antibodies; D007075:Immunoglobulin M