Small RNA helices as substrates for aminoacylation and their relationship to charging of transfer RNAs.
RNA microhelices that reconstruct the acceptor stems of transfer RNAs can be aminoacylated. The anticodon-independent aminoacylation is sequence-specific and suggests a relationship between amino acids and nucleotide sequences which is different from that of the classical genetic code. The specific aminoacylation of RNA microhelices also suggests a highly differentiated adaptation of the structures of aminoacyl-tRNA synthetases to sequences in the acceptor stems of transfer RNAs.
Francklyn
C
C
Department of Biochemistry, University of Vermont College of Medicine, Burlington.
Musier-Forsyth
K
K
Schimmel
P
P
D000595:Amino Acid Sequence; D000604:Amino Acyl-tRNA Synthetases / Q000378:metabolism*; D001483:Base Sequence; D004926:Escherichia coli / Q000378:metabolism; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D012329:RNA, Bacterial / Q000235:genetics / Q000378:metabolism*; D012343:RNA, Transfer / Q000378:metabolism*; D013379:Substrate Specificity
D012329:RNA, Bacterial; D012343:RNA, Transfer; D000604:Amino Acyl-tRNA Synthetases