Pharmacokinetics of brain natriuretic peptide in rats.
The pharmacokinetics of rat brain natriuretic peptide (rBNP) was compared with that of alpha-rat atrial natriuretic peptide (alpha-rANP) in rats. After intravenous infusion in rats (600 pmol min-1kg-1 for 2 min), the disappearance of plasma rBNP was 4-fold slower than that of alpha-rANP. The estimated mean plasma clearance rates for rBNP and alpha-rANP were 45.9 ml min-1kg-1 and 74.4 ml min-1kg-1, respectively. The affinity of rBNP for the clearance receptor or degradation enzyme was considered to be lower than that of alpha-rANP.
Hashimoto
Y
Y
Department of Pharmacy, Kyoto University Hospital, Japan.
Nakao
K
K
Hama
N
N
Mukoyama
M
M
Imura
H
H
Yasuhara
M
M
Hori
R
R
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D001923:Brain Chemistry; D007262:Infusions, Intravenous; D045283:Natriuretic Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats
D045283:Natriuretic Agents; D009320:Atrial Natriuretic Factor