title: Effect of long-term treatment with somatostatin analogue (SMS 201-995) on pituitary tumor shrinkage in acromegaly--report of two cases.
abstract: The effect of long-term somatostatin analogue (SMS 201-995) treatment in two acromegalic patients is reported. Continuous tumor shrinkage was observed even after 129 and 139 weeks of treatment with 600 micrograms of SMS 201-995 daily. A huge and firm adenoma underwent shrinkage during treatment with SMS 201-995. No serious side effect appeared during 160 weeks of treatment. SMS 201-995 has a longterm tumor shrinkage effect and improves endocrinopathies.
authors.affiliation: Department of Neurosurgery, Hiroshima University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Mukada
authors.forename: T
authors.initials: T
authors.lastname: Uozumi
authors.forename: A
authors.initials: A
authors.lastname: Takechi
authors.forename: K
authors.initials: K
authors.lastname: Arita
authors.forename: T
authors.initials: T
authors.lastname: Yano
authors.forename: T
authors.initials: T
authors.lastname: Hirohata
authors.forename: J
authors.initials: J
authors.lastname: Onda
authors.forename: M
authors.initials: M
authors.lastname: Ohta
mesh_terms: D000172:Acromegaly / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D000236:Adenoma / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D000239:Adenoma, Acidophil / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery; D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D015282:Octreotide / Q000627:therapeutic use*; D010911:Pituitary Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery; D011859:Radiography
chemical_list: D015282:Octreotide