Analysis of clastogenic effect of Porto Alegre drinking water supplies on mouse bone marrow cells.
Studies were conducted to evaluate the clastogenic activity of drinking water from Porto Alegre and Guaíba (Rio Grande do Sul, Brazil) estuarine waters. Mouse bone marrow was the target organ. C57B1/6 male and female mice received the water samples as their only liquid supply. Bone marrow cells were collected on the 16th day after the beginning of treatment. The analysis of metaphases demonstrated that the water supplies did not increase the structural chromosome aberration frequencies compared to the control groups. Concerning numerical alterations, only one treated female group showed a significant difference (loss of one chromosome) when compared to the control group, but this result is not considered relevant.
Gimmler-Luz
M C
MC
Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Erdtmann
B
B
Balbueno
R A
RA
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D001938:Brazil; D016009:Chi-Square Distribution; D002869:Chromosome Aberrations; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016296:Mutagenesis; D009152:Mutagenicity Tests / Q000379:methods; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D014881:Water Supply
D014874:Water Pollutants, Chemical