Chromosome aberrations in 450 sperm complements from eight controls and lack of increase after chemotherapy in two patients.
Four hundred fifty sperm complements from eight controls were analyzed. A conservative estimate of aneuploidy was 1.8% with a hyperhaploid rate of 0.9% (4/450). The overall frequency of structural aberrations was 8.9% (40/450). The proportion of X-bearing (47.5%) and Y-bearing (52.5%) sperm did not differ significantly. Sperm complements were analyzed from a cancer patient 9 months after polychemotherapy (n = 63) and from a patient being treated with Imurek (azathioprine) (n = 30). There was no significant increase in the incidence of numerical and structural chromosome aberrations in the sperm of either patient. The percentages of X-bearing and Y-bearing sperm were not significantly different from the expected 50%.
Jenderny
J
J
Institut für Humangenetik und Anthropologie, Universität, Düsseldorf, Federal Republic of Germany.
Jacobi
M L
ML
Rüger
A
A
Röhrborn
G
G
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001379:Azathioprine / Q000009:adverse effects*; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects; D002869:Chromosome Aberrations; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D004359:Drug Therapy, Combination; D004407:Dysgerminoma / Q000188:drug therapy; D006521:Hepatitis, Chronic / Q000188:drug therapy; D006801:Humans; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D013094:Spermatozoa / Q000187:drug effects*; D014751:Vindesine / Q000008:administration & dosage / Q000009:adverse effects
D001761:Bleomycin; D001379:Azathioprine; D002945:Cisplatin; D014751:Vindesine; D011241:Prednisone