[The effect of chloroquine on lymphocytic HLA-A and B antigens].
The author investigated the effect of 20%, 15%, 10%, 5%, 2.5%, 1.25% chloroquine on HLA-A,B antigens on lymphocytes and on the reaction HLA-A,B antigen-antibody. HLA-A,B antigens are not released by chloroquine from the lymphocyte surface and their expressivity does not change, as was revealed by examination of the micro-lymphocytotoxic and absorption test. Higher concentrations of chloroquine cause poly-reactivity of lymphocytes. A 20%, 15% and sometimes also 10% and 5% of chloroquine solution block the reaction HLA-A, B antigen--HLA antibodies. The reason for this is the destructive action of chloroquine on rabbit complement.
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Ustav hematologie a krevní transfúze, Praha.
D002738:Chloroquine / Q000494:pharmacology*; D003601:Cytotoxicity Tests, Immunologic; D015234:HLA-A Antigens / Q000187:drug effects*; D015235:HLA-B Antigens / Q000187:drug effects*; D006801:Humans
D015234:HLA-A Antigens; D015235:HLA-B Antigens; D002738:Chloroquine