title: 12-O-tetradecanoylphorbol 13-acetate induced differentiation in human lung squamous carcinoma cells.
abstract: Three human lung squamous carcinoma cell lines (NX002, CX140 and CX143) demonstrate features of squamous differentiation including involucrin synthesis and competence to form cornified envelopes. 12-O-Tetradecanoylphorbol 13-acetate inhibits growth of these cell lines and this growth inhibition is associated with enhanced differentiation.
authors.affiliation: ICRF Medical Oncology Unit, Western General Hospital, Edinburgh, UK.
authors.forename: G J
authors.initials: GJ
authors.lastname: Rabiasz
authors.forename: S P
authors.initials: SP
authors.lastname: Langdon
authors.forename: L
authors.initials: L
authors.lastname: Anderson
authors.forename: A A
authors.initials: AA
authors.lastname: Ritchie
authors.forename: W R
authors.initials: WR
authors.lastname: Miller
authors.forename: J F
authors.initials: JF
authors.lastname: Smyth
mesh_terms: D000951:Antigens, Neoplasm / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000276:immunology / Q000473:pathology*; D002454:Cell Differentiation / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D007633:Keratins / Q000032:analysis; D008175:Lung Neoplasms / Q000737:chemistry / Q000276:immunology / Q000473:pathology*; D011498:Protein Precursors / Q000032:analysis*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000951:Antigens, Neoplasm; D011498:Protein Precursors; C032253:involucrin; D007633:Keratins; D013755:Tetradecanoylphorbol Acetate