Protective effects of vitamin E against bleomycin-induced genotoxicity in head and neck cancer patients in vitro.
The quantitative protective effects of alpha-tocopherol acid and alpha-tocopherol acid succinate on mutagen-induced genotoxicity were studied in human lymphoblastoid cell lines and lymphocytes from cultures of peripheral blood. Both agents showed a dose-dependent protection both in lymphoblastoid cell lines and in lymphocytes of head and neck cancer patients. The concentrations used were in the phatmacologic concentration range of vitamin E. The protection against genetic toxic effects may be an important part of the cancer-protective effects of vitamin E.
Trizna
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Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Hsu
T C
TC
Schantz
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SP
D016587:Antimutagenic Agents / Q000494:pharmacology*; D001761:Bleomycin / Q000633:toxicity*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000648:ultrastructure; D014810:Vitamin E / Q000494:pharmacology*
D016587:Antimutagenic Agents; D001761:Bleomycin; D014810:Vitamin E