[Action of GABA-positive preparations on uterus-stimulating effects of activating neuromediators, prostaglandin F2 alpha and oxytocin].
Experiments on isolated strips of the non-pregnant rabbit and rat uterus showed the ability of dopamine, noradrenaline, serotonin, acetylcholine, prostaglandin F2 alpha, oxytocin to increase the uterine strips contractile activity. On the other hand, GABA, GABAB receptors agonist phenibut and diazepam inhibit the stimulating effects of the above mentioned substances, thus showing the properties of physiological antagonists of these neuromediators, prostaglandin and oxytocin.
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PI
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D015237:Dinoprost / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004576:Electromyography; D005260:Female; D066298:In Vitro Techniques; D010121:Oxytocin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D014590:Uterine Contraction / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000494:pharmacology*
D000927:Anticonvulsants; D010121:Oxytocin; D005680:gamma-Aminobutyric Acid; D015237:Dinoprost; D003975:Diazepam; C008842:4-amino-3-phenylbutyric acid