Growth factor (M-CSF) and antigenic properties of macrophages in meningioma.
In meningiomas, transformed meningeal cells can share morphological aspects (in hemangiopericytic meningioma) and antigenic properties (i.e.: HLA-DR antigens expression) with elements of the monocyte/macrophage lineage. In this report, we describe a case of a highly vascular meningioma where numerous tumor cells, studied with immunohistochemical methods, present phenotypic properties of macrophages. Moreover, the cerebrospinal fluid (CF) analysis disclosed, using a biological assay, a high level of a growth factor for monocytic elements, the Macrophages Colony Stimulating Factor (M-CSF). Our findings may confirm that transitional aspects between different mesenchymal cells could be present in meningiomas.
Giometto
B
B
II Neurological Clinic, University of Padova, School of Medicine, Italy.
Bozza
F
F
Gallo
P
P
Pagni
S
S
Argentiero
V
V
Ferla
S
S
Mingrino
S
S
Tavolato
B
B
D015703:Antigens, CD / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000134:cerebrospinal fluid; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D016173:Macrophage Colony-Stimulating Factor / Q000134:cerebrospinal fluid*; D008264:Macrophages / Q000276:immunology / Q000473:pathology*; D008562:Membrane Glycoproteins / Q000032:analysis; D008577:Meningeal Neoplasms / Q000134:cerebrospinal fluid / Q000276:immunology / Q000473:pathology*; D008875:Middle Aged; D018396:Mucin-1; D009113:Muramidase / Q000032:analysis; D014746:Vimentin / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000032:analysis
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D006680:HLA Antigens; D006684:HLA-DR Antigens; D008562:Membrane Glycoproteins; D018396:Mucin-1; D014746:Vimentin; D000515:alpha 1-Antitrypsin; D007633:Keratins; D016173:Macrophage Colony-Stimulating Factor; D009113:Muramidase