Propylene glycol as a vehicle for percutaneous absorption of therapeutic agents.
Propylene glycol (PG) was evaluated as a vehicle for the in vivo percutaneous absorption of the hydrochloride salts of desipramine, nortriptyline, procainamide, and N-acetyl-procainamide. Each drug was administered topically to hairless (hr-1/hr-1) mice in water and in aqueous 10% and 50% PG. Mean drug concentrations in blood, brain, heart, liver, and lung were measured by high-pressure liquid chromatography after either two or three hours of topical absorption. The presence of PG generally enhanced the absorption of each drug, and the degree of enhancement appeared to be related to the percentage of PG in the dosing solution.
Bailey
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DN
Department of Pathology, University of California Medical Center, San Diego 92103-8320.
D000120:Acecainide / Q000008:administration & dosage / Q000493:pharmacokinetics; D000818:Animals; D003891:Desipramine / Q000008:administration & dosage / Q000493:pharmacokinetics; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D009661:Nortriptyline / Q000008:administration & dosage / Q000493:pharmacokinetics; D014677:Pharmaceutical Vehicles; D011342:Procainamide / Q000008:administration & dosage / Q000493:pharmacokinetics; D019946:Propylene Glycol; D011409:Propylene Glycols / Q000008:administration & dosage*; D012869:Skin Absorption
D014677:Pharmaceutical Vehicles; D011409:Propylene Glycols; D019946:Propylene Glycol; D000120:Acecainide; D009661:Nortriptyline; D011342:Procainamide; D003891:Desipramine