title: Impairment of cerebral biogenic amine synthesis in a patient receiving high-dose methotrexate.
abstract: A transient acute neurologic syndrome occurred in a 15-year-old boy receiving high-dose methotrexate (MTX) for acute lymphoblastic leukemia. Cerebrospinal fluid analysis revealed a decrease of homovanillic acid and 5-hydroxyindoleacetic acid concentrations with a rise of biopterin levels. These findings suggest that MTX can induce a transient alteration of the metabolism of tetrahydrobiopterin leading to the defect of biogenic amine neurotransmitter synthesis.
authors.affiliation: Service d'Hématologie clinique, Centre Hospitalier, France.
authors.forename: F
authors.initials: F
authors.lastname: Millot
authors.forename: J L
authors.initials: JL
authors.lastname: Dhondt
authors.forename: J M
authors.initials: JM
authors.lastname: Hayte
authors.forename: F
authors.initials: F
authors.lastname: Bauters
mesh_terms: D000293:Adolescent; D001679:Biogenic Amines / Q000096:biosynthesis*; D001708:Biopterins / Q000134:cerebrospinal fluid; D001921:Brain / Q000378:metabolism*; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008727:Methotrexate / Q000008:administration & dosage*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000134:cerebrospinal fluid / Q000188:drug therapy*
chemical_list: D001679:Biogenic Amines; D001708:Biopterins; D006897:Hydroxyindoleacetic Acid; D006719:Homovanillic Acid; D008727:Methotrexate