Pharmacological manipulation of peripheral resistance during distal vascular reconstruction.
A randomised placebo-controlled trial was conducted to investigate the effects of iloprost, a stable prostacyclin analogue, on peripheral resistance, during femoro-crural arterial bypass. 3000 ng of iloprost, infused into the graft, produced an immediate drop in peripheral resistance by a mean (range) of 43% (4-80%; p less than 0.01, Wilcoxon). Decreased peripheral resistance persisted to 20 minutes. Graft flow during the same period increased by 59.8% (-7 to 294%; p less than 0.01) and this increase persisted after the operation. Iloprost produces an immediate decrease in peripheral resistance associated with a prolonged increase in graft blood flow. This may reduce graft failure in the early postoperative period.
Smith
F C
FC
University Department of Vascular Surgery, Queen Elizabeth Hospital, Birmingham, UK.
Shearman
C P
CP
D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity / Q000502:physiology; D003131:Combined Modality Therapy; D005260:Female; D005528:Foot / Q000098:blood supply*; D006083:Graft Occlusion, Vascular / Q000503:physiopathology; D006801:Humans; D016285:Iloprost / Q000008:administration & dosage*; D007511:Ischemia / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012501:Saphenous Vein / Q000637:transplantation*; D014655:Vascular Resistance / Q000187:drug effects* / Q000502:physiology
D016285:Iloprost