title: [Motor fluctuations in Parkinson disease: risk factors].
abstract: We studied the histories of 173 patients with Parkinson's disease (1985-1987) chronically treated with levodopa + dopa decarboxylase inhibitor. Ninety four patients had daily motor fluctuations and 79 showed stable motor response. The most significant differences between fluctuating and stable patients were given by age at disease onset and duration of levodopa therapy. Patient with disease onset before 60 had a greater risk (p less than 0.001) of developing fluctuations. Delaying the initiation of levodopa treatment was not associated with a smaller incidence of fluctuations.
authors.affiliation: Departamento de Neurología, Clínica Universitaria de Navarra, Pamplona.
authors.forename: F
authors.initials: F
authors.lastname: Grandas
authors.forename: M R
authors.initials: MR
authors.lastname: Luquin
authors.forename: M
authors.initials: M
authors.lastname: Rodríguez
authors.forename: J
authors.initials: J
authors.lastname: Vaamonde
authors.forename: G
authors.initials: G
authors.lastname: Lera
authors.forename: J A
authors.initials: JA
authors.lastname: Obeso
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007980:Levodopa / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000187:drug effects*; D010300:Parkinson Disease / Q000188:drug therapy* / Q000503:physiopathology; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors
chemical_list: D007980:Levodopa