[Reduction of voluntary alcohol consumption under the effects of prolonged-action zinc].
It was revealed that an involuntary rats' intoxication with 10% ethanol solution during 8 months caused a reduction of zinc content in the brain. A subcutaneous depot administration of highly dispersed zinc powder in a dose of 5 mg/kg reduced ethanol consumption under conditions of free choice for two weeks. This effect of the preparation was associated with normalization of zinc content and increase of a malondialdehyde level in the brain.
Skal'nyĭ
A V
AV
Kukhtina
E N
EN
Ol'khovskaia
I P
IP
Glushchenko
N N
NN
D000428:Alcohol Drinking; D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003300:Copper / Q000378:metabolism; D003692:Delayed-Action Preparations; D007279:Injections, Subcutaneous; D007501:Iron / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D013997:Time Factors; D015032:Zinc / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*
D003692:Delayed-Action Preparations; D008315:Malondialdehyde; D003300:Copper; D007501:Iron; D015032:Zinc