[Potentiation of the antitumoral effect of electrochemotherapy by immunotherapy with allogeneic cells producing interleukin 2].
Electrochemotherapy (ECT) is a new antitumour treatment which consists of delivering electric pulses to the tumour a few minutes after an intravenous injection of bleomycin. The antitumour efficacy of ECT is increased by local injections of interleukin 2 (IL2) in the oedema which appears at the site of the treated tumours. We have shown that tumour cells inoculated in syngeneic mice are rejected if IL2 secreting allo- or xenogeneic cells are co-injected with tumour cells. We report here the large increase of ECT therapeutical efficacy when allogeneic cells secreting IL2 are injected into the peri-tumoural oedema.
Mir
L M
LM
Unité de Biochimie-Enzymologie de l'I.G.R., U.R.A. 147 C.N.R.S., U. 140, I.N.S.E.R.M., Institut Gustave-Roussy, Villejuif.
Roth
C
C
Orlowski
S
S
Belehradek
J
J
Fradelizi
D
D
Paoletti
C
C
Kourilsky
P
P
D000818:Animals; D001761:Bleomycin / Q000008:administration & dosage; D004487:Edema / Q000188:drug therapy / Q000209:etiology; D004563:Electrochemistry / Q000379:methods*; D005260:Female; D007167:Immunotherapy; D007275:Injections, Intravenous; D007376:Interleukin-2 / Q000032:analysis / Q000627:therapeutic use*; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation / Q000473:pathology; D009369:Neoplasms / Q000628:therapy*; D012513:Sarcoma, Experimental / Q000473:pathology / Q000628:therapy*; D012871:Skin Diseases / Q000188:drug therapy / Q000209:etiology; D014184:Transplantation, Homologous
D007376:Interleukin-2; D001761:Bleomycin