title: The accident at Chernobyl and trisomy 21 in Finland.
abstract: Our objective was to explore whether the radiation fallout in Finland after the accident at the Chernobyl nuclear power plant in April 1986 led to an increased incidence of trisomy 21. In this geographic and temporal cohort study, the country was divided into three zones according to the amounts of radioactive fallout and internal radiation caused by two cesium isotopes. The 518 cytologically verified cases of trisomy 21 were divided into a control group (conceived before the accident), and a study group of children whose expected dates of birth were in the post-accident years 1987-1988, i.e., pregnancies commenced after May 1986. The cases were also divided into three subgroups according to the zones of radiation. There were no significant differences in prevalence of trisomy 21 between the control and study groups nor between the three zones in spite of the significant differences in the levels of radiation and in the body burden that prevailed throughout the study period. Power estimates showed that in the two zones of lower radiation, an increase of 0.5% in the prevalence would have been detected with a power of 0.85, and in the somewhat smaller zone of the highest radiation, with a power of 0.70. The study lends no further support to the view that the low radiation fallout in western Europe would have been causally associated with trisomy 21.
authors.affiliation: Department of Pathology, University of Helsinki, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Harjulehto-Mervaala
authors.forename: R
authors.initials: R
authors.lastname: Salonen
authors.forename: T
authors.initials: T
authors.lastname: Aro
authors.forename: L
authors.initials: L
authors.lastname: Saxén
mesh_terms: D000059:Accidents; D002588:Cesium Radioisotopes / Q000009:adverse effects; D002891:Chromosomes, Human, Pair 21 / Q000528:radiation effects*; D015331:Cohort Studies; D004314:Down Syndrome / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D016555:Matched-Pair Analysis; D008423:Maternal Age; D009688:Nuclear Reactors; D011210:Power Plants; D011247:Pregnancy; D018566:Pregnancy, High-Risk; D011297:Prenatal Exposure Delayed Effects; D015995:Prevalence; D011847:Radioactive Fallout / Q000009:adverse effects; D014314:Trisomy; D014455:Ukraine
chemical_list: D002588:Cesium Radioisotopes; D011847:Radioactive Fallout