Determination of topanol antioxidants in methacrylates using capillary gas-liquid chromatography.
This paper presents a method to identify and determine topanol A and topanol O antioxidants in methylmethacrylate and 11-bromoundecylmethacrylate. The method is both simple and rapid. Analysis is performed on a 10 m x 0.53 mm I.D. HP-1 capillary gas chromatography column with a temperature gradient and a high carrier gas flow-rate (16.5 ml/min). Quantitation is by internal standardisation. Validation of the method is described for both topanols at concentrations of approximately 50 ppm in methylmethacrylate and 250 ppm in 11-bromoundecylmethacrylate.
Smith
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ID
SmithKline Beecham Pharmaceuticals, Tonbridge, Kent, UK.
Waters
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DG
D000975:Antioxidants / Q000032:analysis*; D002084:Butylated Hydroxytoluene / Q000032:analysis*; D002849:Chromatography, Gas; D003408:Cresols / Q000032:analysis*; D008689:Methacrylates / Q000032:analysis*; D020366:Methylmethacrylate; D008768:Methylmethacrylates / Q000032:analysis; D011786:Quality Control
D000975:Antioxidants; D003408:Cresols; D008689:Methacrylates; D008768:Methylmethacrylates; D020366:Methylmethacrylate; D002084:Butylated Hydroxytoluene; C076882:11-bromoundecyl methacrylate; C076883:topanol A