Cytokeratin expression in mucinous sweat gland carcinomas: an immunohistochemical analysis of four cases.
Four mucinous sweat gland carcinomas were examined for the distribution of cytokeratin (CK) polypeptides using immunohistochemical techniques on paraffin-embedded sections. All the tumour specimens reacted with monoclonal antibodies to CK 7, CK 8, CK 18 and CK 19. Antibodies to CK 1, CK 1/2/10/14, CK 1/5/10/11, CK 13, CK 14 and CK 20 did not stain any of the carcinomas. The results add additional support to the notion that mucinous sweat gland carcinoma represents a tumour histogenetically related to the eccrine secretory coil. Furthermore, the absence of CK 20 might significantly contribute to the differentiation of this tumour from cutaneous metastases from gastrointestinal carcinomas.
Eckert
F
F
Department of Dermatology, University of Munich, Germany.
Schmid
U
U
Hardmeier
T
T
Altmannsberger
M
M
D002288:Adenocarcinoma, Mucinous / Q000737:chemistry* / Q000473:pathology; D000368:Aged; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000737:chemistry* / Q000473:pathology; D013544:Sweat Gland Neoplasms / Q000737:chemistry* / Q000473:pathology
D007633:Keratins