[The immunogenic activity of the Lassa virus structural proteins].
The immunogenic properties of Lassa virus GP1, GP2, and NP polypeptides were studied in rabbits. Lassa virus NP polypeptide, in contrast to GP1 and GP2 polypeptides, was shown to induce the highest titres of antibodies determined by IFA and ELISA tests. Moreover, the antibody relative avidity experiment showed that the anti-NP antibodies has ELISA index of 0.63 whereas anti-GP1 and anti-GP2 antisera had those of 0.49 and 0.28, respectively.
Bystrova
S I
SI
Lemeshko
N N
NN
Shkolina
T V
TV
Vladyko
A S
AS
D000818:Animals; D000915:Antibody Affinity; D000918:Antibody Specificity; D002213:Capsid / Q000276:immunology; D000939:Epitopes; D006023:Glycoproteins / Q000276:immunology; D007106:Immune Sera / Q000032:analysis; D007114:Immunization / Q000379:methods; D007124:Immunoenzyme Techniques; D007836:Lassa virus / Q000276:immunology*; D011817:Rabbits; D014758:Viral Core Proteins / Q000276:immunology; D014759:Viral Envelope Proteins / Q000276:immunology; D015678:Viral Structural Proteins / Q000276:immunology*
D000939:Epitopes; D006023:Glycoproteins; D007106:Immune Sera; D014758:Viral Core Proteins; D014759:Viral Envelope Proteins; D015678:Viral Structural Proteins; C066508:glycoprotein gp1, lassa virus; C077198:glycoprotein gp2, lassa virus