The effect of cycloheximide on natural and X-ray-induced cell death in the developing cerebral cortex.
Naturally occurring cell death in the cerebral cortex and subcortical white matter is increased after X-irradiation, and this process is curbed with cycloheximide, an inhibitor of protein synthesis. However, cycloheximide alone increases cell death during development, and this effect is dose-dependent. This suggests that, in both normal and experimentally-induced cortical cell death during development, different proteins are activated or inhibited, depending on the agent, the time of its application, and the previous metabolic or functional state of the cell.
Ferrer
I
I
Unidad Neuropatología, Universidad de Barcelona, Hospitalet de Llobregat, Barcelona, Spain.
D000818:Animals; D016923:Cell Death / Q000187:drug effects / Q000528:radiation effects*; D002540:Cerebral Cortex / Q000166:cytology* / Q000254:growth & development / Q000528:radiation effects; D003513:Cycloheximide / Q000494:pharmacology*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D011247:Pregnancy; D051381:Rats; D014965:X-Rays
D003513:Cycloheximide