title: Auditory evoked response and awareness: a study in volunteers at sub-MAC concentrations of isoflurane.
abstract: We have investigated the relationship between the auditory evoked response (AER) and simple tests of conscious awareness at four end-expiratory concentrations (0.0, 0.1, 0.2 and 0.4 MAC) of isoflurane in oxygen in each of eight anaesthetist volunteers, in random order, at least 1 week apart. The early cortical AER was recorded from electrodes at the vertex and inion. Amplitudes of the waves Pa, Nb and Pc and latencies of the waves Na, Pa, Nb, Pb and Nc were measured. All the AER variables were highly significantly related to end-expiratory anaesthetic concentration. Amplitudes decreased and latencies increased progressively with increasing anaesthetic concentration. The AER variables were also highly significantly related to the level of response. Amplitudes were greatest and the latencies shortest when there was full response to command. (Nb latency increased from 47.5 to 54.5 ms between partial and no response.) The close correlation between the effects of concentration and level of response, and between concentration and the AER implied that it was difficult to demonstrate those changes in the AER which specifically relate to changes in response. At 0.2 MAC, however, which was the concentration at which all subjects showed some deficit, the response to a shock word was distinguished clearly by Nb latency. In eight of 24 possible comparisons (eight AER variables and three types of psychological test) the AER fitted the response more closely than concentration.
authors.affiliation: Division of Anaesthesia, Clinical Research Centre, Harrow, Middlesex.
authors.forename: D E
authors.initials: DE
authors.lastname: Newton
authors.forename: C
authors.initials: C
authors.lastname: Thornton
authors.forename: K M
authors.initials: KM
authors.lastname: Konieczko
authors.forename: C
authors.initials: C
authors.lastname: Jordan
authors.forename: N R
authors.initials: NR
authors.lastname: Webster
authors.forename: N P
authors.initials: NP
authors.lastname: Luff
authors.forename: C D
authors.initials: CD
authors.lastname: Frith
authors.forename: C J
authors.initials: CJ
authors.lastname: Doré
mesh_terms: D001364:Awareness / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D006801:Humans; D007530:Isoflurane / Q000008:administration & dosage / Q000494:pharmacology*; D008568:Memory / Q000187:drug effects; D011897:Random Allocation; D011930:Reaction Time / Q000187:drug effects; D014838:Volunteers
chemical_list: D007530:Isoflurane