Antiandrogen. I. 2-azapregnane and 2-oxapregnane steroids.
2-Azachlormadinone acetate (5a, 17-acetoxy-6-chloro-2-azapregna-4,6-diene- 3,20-dione), 2-oxachlormadinone acetate (6, 17-acetoxy-6-chloro-2-oxapregna-4,6-diene-3,20-dione) and the derivatives were prepared as potential antiandrogenic agents. Biological evaluation showed that 5a and 6 had a potent antiandrogenic activity when tested in the castrated male rat.
Shibata
K
K
Research Department, Teikoku Hormone Mfg. Co., Ltd., Kawasaki, Japan.
Takegawa
S
S
Koizumi
N
N
Yamakoshi
N
N
Shimazawa
E
E
D000726:Androgen Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D002715:Chlormadinone Acetate / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D008297:Male; D011278:Pregnanes / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013260:Steroids, Heterocyclic / Q000138:chemical synthesis* / Q000494:pharmacology
D000726:Androgen Antagonists; D011278:Pregnanes; D013260:Steroids, Heterocyclic; D002715:Chlormadinone Acetate; C076708:2-azachlormadinone acetate; C069297:osaterone acetate