Biodegradable microspheres containing adriamycin in the treatment of proliferative vitreoretinopathy.
The use of biodegradable polymer microspheres containing adriamycin for the treatment of proliferative vitreoretinopathy (PVR) in an experimental rabbit model was investigated. A single injection of microspheres containing 10 micrograms of adriamycin effectively decreased traction retinal detachment to 10% (n = 10), whereas 50% of eyes injected with blank microspheres (n = 10) developed retinal detachment (P < 0.05). A single injection of microspheres, containing 3 micrograms of adriamycin, did not suppress retinal detachment. Electroretinographic and histologic studies confirmed that the 10 micrograms injection of adriamycin in microspheres was not toxic to the retina, although the injection of the same amount of free adriamycin caused retinal necrosis and detachment. Thus, microspheres containing adriamycin hold promise as a new treatment modality for PVR.
Moritera
T
T
Department of Ophthalmology, Faculty of Medicine, Kyoto University, Japan.
Ogura
Y
Y
Yoshimura
N
N
Honda
Y
Y
Wada
R
R
Hyon
S H
SH
Ikada
Y
Y
D000818:Animals; D001673:Biodegradation, Environmental; D003692:Delayed-Action Preparations; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000008:administration & dosage* / Q000627:therapeutic use; D004337:Drug Carriers; D004596:Electroretinography; D005128:Eye Diseases / Q000188:drug therapy / Q000473:pathology; D005654:Fundus Oculi; D008863:Microspheres; D011817:Rabbits; D012160:Retina / Q000187:drug effects / Q000473:pathology; D012163:Retinal Detachment / Q000473:pathology / Q000517:prevention & control; D012164:Retinal Diseases / Q000188:drug therapy* / Q000473:pathology; D014822:Vitreous Body / Q000473:pathology
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004317:Doxorubicin