Substance P, vasoactive intestinal polypeptide, and gastrin catabolism in canine liver and kidney.
No reports have described the catabolic mechanism of substance P in vivo. We studied the effects of hepatic or renal transit on substance P, vasoactive intestinal polypeptide, and gastrin in anesthetized dogs. It was found that the liver plays a more important role in vasoactive intestinal polypeptide catabolism than the kidney and that the kidney is more important in gastrin catabolism than the liver. Substance P was more rapidly degraded than the other two peptides in both organs. The transrenal substance P loss measured by C-terminal antiserum differed from that measured by N-terminal antiserum, although there was no difference in the liver. This suggested that there were different patterns of cleavage of substance P between the liver and the kidney, and that its C terminal was degraded more strongly than its N terminal in the kidney.
Kabemura
T
T
Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Misawa
T
T
Chijiiwa
Y
Y
Nasu
T
T
Nawata
H
H
D000818:Animals; D004285:Dogs; D005755:Gastrins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006207:Half-Life; D007262:Infusions, Intravenous; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008657:Metabolic Clearance Rate; D011863:Radioimmunoassay; D013373:Substance P / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors; D014660:Vasoactive Intestinal Peptide / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D005755:Gastrins; D013373:Substance P; D014660:Vasoactive Intestinal Peptide