Sex difference for tolerance of 5-HT1A receptor-mediated temperature and corticosterone responses in mice.
Repeated treatment with 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) resulted in significant attenuation of 8-OH-DPAT-induced hypothermia and adrenocorticol effect in mice of both sexes, while it did not affect the 8-OH-DPAT-induced decrease in 5-hydroxyindoleacetic acid in the hypothalamus in either sex. The attenuated responses developed more rapidly in female than in male mice, indicating sex differences in the adaptive regulation of the 5-HT1A receptor-mediated responses.
Nakano
Y
Y
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka, Japan.
Matsuda
T
T
Takuma
K
K
Yoshikawa
T
T
Baba
A
A
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D003345:Corticosterone / Q000097:blood*; D005260:Female; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D051379:Mice; D011985:Receptors, Serotonin / Q000378:metabolism*; D012727:Sex Characteristics
D011985:Receptors, Serotonin; D006897:Hydroxyindoleacetic Acid; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D003345:Corticosterone