Suppressive effect of polyoxometalates on the cytopathogenicity of human immunodeficiency virus type 1 (HIV-1) in vitro and their inhibitory activity against HIV-1 reverse transcriptase.
One isopolyoxometalate and 42 heteropolyoxometalates consisting of 3 compounds with the trivacant Keggin structure, 2 with the lacunary Keggin structure, 30 with the Keggin structure, one with the Wells-Dawson structure and 6 with miscellaneous structures were tested for their suppressive effect on the cytopathogenicity of human immunodeficiency virus type 1 (HIV-1) in vitro and inhibitory activity against HIV-1 reverse transcriptase. In contrast to the leading interpretations which attribute the suppressive effect of polyoxometalates on the cytopathogenicity of HIV-1 to the inhibition of HIV-1 reverse transcriptase by these compounds, there was no distinct correlation observed between these two functions of polyoxometalates.
Inouye
Y
Y
Institute of Pharmaceutical Sciences, Hiroshima, Japan.
Tokutake
Y
Y
Kunihara
J
J
Yoshida
T
T
Yamase
T
T
Nakata
A
A
Nakamura
S
S
D000965:Antimony / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D015497:HIV-1 / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D011108:Polymers / Q000494:pharmacology*; D018894:Reverse Transcriptase Inhibitors; D014414:Tungsten / Q000494:pharmacology*; D017973:Tungsten Compounds
D000998:Antiviral Agents; D011108:Polymers; D018894:Reverse Transcriptase Inhibitors; D017973:Tungsten Compounds; C009613:ammonium tungsten antimonate hydroxide oxide; D000965:Antimony; D014414:Tungsten