Embedding of dithranol in lipid crystals.
A new cream base, based on lipid crystals, was used to formulate an antipsoriatic cream containing Dithranol. The cream consists of solid lipid crystals of C12 and C14 monoglycerides. The lipids are solid at room temperature but melt at skin temperature. The cream is easy to wash off, provides good stability of dithranol, and is practically nonstaining.
Lindahl
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Hydro Pharma AB, Malmö, Sweden.
D000875:Anthralin / Q000008:administration & dosage*; D003460:Crystallization; D004355:Drug Stability; D008055:Lipids; D013194:Staining and Labeling
D008055:Lipids; D000875:Anthralin