title: Atrial automatic tachycardia in infancy and childhood.
abstract: Twenty-one cases (13 male, eight female) of atrial automatic tachycardia (AAT) assessed by standard and Holter-ECG in otherwise healthy infants and children have been documented. AAT was incessant in 12 patients, repetitive in seven, and of undetermined type in the remaining two. The frontal P wave axis suggested an ectopic focus in the high right atrium or right atrial appendage in 13 patients, in the low right atrium in one patient, and in the left atrium in seven patients. Thirteen out of 14 patients with the incessant or undetermined type of AAT were symptomatic, in contrast to only two of seven patients with the repetitive type. All patients were treated with between one and eight (median three) antiarrhythmic drugs. The most effective drug was amiodarone, followed by the class I C antiarrhythmic drugs, propafenone and flecainide. At present, all patients are alive 4 months to 21 years (median 2.5 years) after diagnosis of AAT. Twelve patients are in sinus rhythm, five of them without any medication. Nine patients still have AAT, which, however, is repetitive or intermittent in all but one. In conclusion, AAT is an unusual, and in its incessant form often severely symptomatic arrhythmia, which is resistant to conventional antiarrhythmic medication. However, amiodarone and class I C antiarrhythmic drugs are frequently effective. Since medical treatment with these drugs is often successful, and AAT may resolve completely, a conservative approach is indicated in many cases.
authors.affiliation: Department of Pediatric Cardiology, RWTH Aachen, Germany.
authors.forename: G
authors.initials: G
authors.lastname: von Bernuth
authors.forename: W
authors.initials: W
authors.lastname: Engelhardt
authors.forename: H H
authors.initials: HH
authors.lastname: Kramer
authors.forename: H
authors.initials: H
authors.lastname: Singer
authors.forename: P
authors.initials: P
authors.lastname: Schneider
authors.forename: H
authors.initials: H
authors.lastname: Ulmer
authors.forename: S
authors.initials: S
authors.lastname: Brodherr-Heberlein
authors.forename: W
authors.initials: W
authors.lastname: Kienast
authors.forename: D
authors.initials: D
authors.lastname: Lang
authors.forename: A
authors.initials: A
authors.lastname: Lindinger
mesh_terms: D000293:Adolescent; D000638:Amiodarone / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D015716:Electrocardiography, Ambulatory; D005260:Female; D005424:Flecainide / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008297:Male; D011379:Prognosis; D011405:Propafenone / Q000627:therapeutic use; D013612:Tachycardia, Ectopic Atrial / Q000188:drug therapy / Q000503:physiopathology*
chemical_list: D011405:Propafenone; D005424:Flecainide; D000638:Amiodarone