title: Acute thrombosis of prosthetic valves: a multivariate analysis of the risk factors for a lifethreatening event.
abstract: In 3231 prosthetic valves implanted between January 1975 and November 1990, we observed 61 cases of prosthetic obstruction of biological origin with clinical and laboratory findings of severe functional impairment which required surgery as emergency treatment. The hospital mortality was 19.67% (12/61). The obstruction was due to a primary thrombosis in all 5 bioprostheses which were not anticoagulated and in 11/56 (19.64%) mechanical prostheses of which 3 were not anticoagulated and 4 were not properly anticoagulated. The obstruction was due to fibrous tissue overgrowth in the other 45 mechanical prostheses (80.35%) with secondary thrombosis in 34 cases (60.71%) and no thrombosis in 11 (19.64%); 71.11% of these prostheses were adequately anticoagulated. Of the 61 obstructed prostheses, 53 were mitral and 8 were aortic. No tricuspid obstruction was observed. A statistical assessment by multiple correspondence, cluster and chi square analysis was performed in two groups of patients with different models of mechanical mitral prostheses. The 5-year actuarial incidence of obstruction was 6.08%. Significant risk factors were: tilting disc prostheses, prostheses without pyrocarbon coating, large prostheses, tilting disc prostheses with a small orifice posteriorly oriented, atrial fibrillation, enlarged left atrium, time from implant greater than 4 years, age between 40 and 50 years. In our opinion, prosthetic obstruction may be referred to a primary thrombosis only in cases where it may be prevented by adequate anticoagulation. In most cases, the obstruction is produced by periprosthetic fibroblastic proliferation which may develop in spite of adequate anticoagulation in both groups.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Institute of Cardiac Surgery, V. Monaldi Hospital, University of Naples 1st Medical School, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Renzulli
authors.forename: L
authors.initials: L
authors.lastname: De Luca
authors.forename: A
authors.initials: A
authors.lastname: Caruso
authors.forename: R
authors.initials: R
authors.lastname: Verde
authors.forename: D
authors.initials: D
authors.lastname: Galzerano
authors.forename: M
authors.initials: M
authors.lastname: Cotrufo
mesh_terms: D000208:Acute Disease; D000328:Adult; D001021:Aortic Valve; D001705:Bioprosthesis; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve; D015999:Multivariate Analysis; D011300:Preoperative Care; D011475:Prosthesis Failure; D012307:Risk Factors; D013927:Thrombosis / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology / Q000601:surgery