title: Mechanical preprocessing in the mammalian cochlea.
abstract: The mammalian cochlea responds with exquisite sensitivity to the small fluctuations in air pressure that make up the stimulus of sound. Moreover, it responds to pressure fluctuations that occur extremely rapidly and that vary over a wide range of intensities--in both cases, to an extent outside the capabilities of unaided nerve fibres. Research performed during the past decade has shown that these properties are dependent on a physiological source of mechanical energy that operates probably within the outer hair cells of the organ of Corti. These cells, which are anatomically and functionally similar to the primary receptor cells, the inner hair cells, are believed to function as a source of mechanical power to assist the mechanical sensitivity of the cochlea, by mechanisms that currently are not understood. Several possible mechanisms have been proposed, but each has limitations that may make it an unsuitable candidate. Recent work has also demonstrated the likely role of mechanoelectrical transduction in outer hair cells in controlling the power source and thereby influencing the sensitivity and amplitude range of the cochlea.
authors.affiliation: Dept of Physiology, University of Western Australia, Nedlands.
authors.forename: G K
authors.initials: GK
authors.lastname: Yates
authors.forename: B M
authors.initials: BM
authors.lastname: Johnstone
authors.forename: R B
authors.initials: RB
authors.lastname: Patuzzi
authors.forename: D
authors.initials: D
authors.lastname: Robertson
mesh_terms: D000818:Animals; D003051:Cochlea / Q000502:physiology*; D006801:Humans; D008322:Mammals / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology