title: Perfluoroalkylated surfactants: relationships between structure and acute toxicity in mice.
abstract: New single chain neutral, and single and double chain zwitterionic perfluoroalkylated surfactants or co-surfactants have been evaluated for in vivo applications. A study of the relationship between structure and acute toxicity in mice is presented. Acute toxicity evaluations i.v. in mice indicate the following trends (increasing tolerance): zwitterionic single-chain less than neutral single-chain less than zwitterionic double-chain and, where the polar head is concerned, single-chain compounds: phosphocholine less than phosphoramidate less than trehalose approximately sucrose less than maltose less than xylitol.
authors.affiliation: Centre de Transfusion Sanguine des Alpes Maritimes, St Laurent du Var, France.
authors.forename: A M
authors.initials: AM
authors.lastname: Mahé
authors.forename: J
authors.initials: J
authors.lastname: Manoux
authors.forename: A
authors.initials: A
authors.lastname: Valla
authors.forename: R
authors.initials: R
authors.lastname: Follana
authors.forename: L
authors.initials: L
authors.lastname: Zarif
authors.forename: J
authors.initials: J
authors.lastname: Greiner
authors.forename: P
authors.initials: P
authors.lastname: Vierling
authors.forename: J G
authors.initials: JG
authors.lastname: Riess
mesh_terms: D000818:Animals; D001802:Blood Substitutes / Q000737:chemistry / Q000633:toxicity; D002240:Carbohydrate Sequence; D003287:Contrast Media / Q000737:chemistry / Q000633:toxicity; D005466:Fluorocarbons / Q000737:chemistry / Q000633:toxicity*; D051379:Mice; D008969:Molecular Sequence Data; D013329:Structure-Activity Relationship; D013501:Surface-Active Agents / Q000737:chemistry / Q000633:toxicity*
chemical_list: D001802:Blood Substitutes; D003287:Contrast Media; D005466:Fluorocarbons; D013501:Surface-Active Agents