Attempts to induce immune-mediated cerebral arterial injury for an experimental model of moyamoya disease.
To examine the possible role of immune complex-mediated reactions in moyamoya disease, a novel experimental system using a serum sickness vasculitis model combined with intracisternal administration of antibodies or antigens was developed. Twenty-eight male Japanese white rabbits were divided into four experimental groups. Group I was treated twice with intravenous injections of heterologous serum. In group II, intracisternal administration of antibodies or antigens was combined with the second injection of serum. Group III received a single intravenous injection of antigens simultaneously with intracisternal administration of antibodies. Group IV was a technical control group. Cerebral arteritis, although likely in the initial process, was induced only in groups II and III. This study suggests that the cerebral arteries rarely develop arteritis in a serum sickness model alone. The cerebral arteries may require additional intracisternal administration of antibodies or antigens to induce in situ deposition of immune complexes around them.
Ezura
M
M
Division of Neurosurgery, School of Medicine, Tohoku University, Sendai, Japan.
Fujiwara
S
S
Nose
M
M
Yoshimoto
T
T
Kyogoku
M
M
D000818:Animals; D000910:Antibodies, Heterophile / Q000008:administration & dosage / Q000276:immunology; D000936:Antigen-Antibody Complex / Q000032:analysis; D015478:Antigens, Heterophile / Q000008:administration & dosage / Q000276:immunology; D001167:Arteritis / Q000276:immunology / Q000473:pathology; D002536:Cerebral Arteries / Q000276:immunology* / Q000473:pathology; D004195:Disease Models, Animal; D007105:Immune Complex Diseases / Q000276:immunology* / Q000473:pathology; D008297:Male; D009072:Moyamoya Disease / Q000276:immunology* / Q000473:pathology; D011817:Rabbits; D012713:Serum Sickness / Q000276:immunology / Q000473:pathology
D000910:Antibodies, Heterophile; D000936:Antigen-Antibody Complex; D015478:Antigens, Heterophile