title: Electrophysiological findings in a case of severe intrathecal baclofen overdose.
abstract: Multimodality evoked potentials were examined in a case of serious accidental intrathecal baclofen overdose in a patient who suffered from severe spasticity due to a traumatic brain lesion. Electrophysiological findings during, before and after the intoxication were compared. Transcranial electrical stimulation up to 750 V did not evoke any responses in thenar muscles on the first day of intoxication. An improvement to normal values was observed within 3 days, paralleled by an amelioration of the patient's clinical condition. Cervical electrical stimulation was largely unaffected by baclofen. Median nerve somatosensory and brain-stem acoustic evoked potentials revealed few or no differences during intoxication compared to pre- and post-intoxication responses.
authors.affiliation: Department of Neurology, Innsbruck University, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Kofler
authors.forename: L
authors.initials: L
authors.lastname: Saltuari
authors.forename: E
authors.initials: E
authors.lastname: Schmutzhard
authors.forename: K
authors.initials: K
authors.lastname: Berek
authors.forename: H
authors.initials: H
authors.lastname: Baumgartner
authors.forename: L
authors.initials: L
authors.lastname: Russegger
authors.forename: F
authors.initials: F
authors.lastname: Aichner
mesh_terms: D000293:Adolescent; D001418:Baclofen / Q000506:poisoning*; D062787:Drug Overdose / Q000503:physiopathology; D004558:Electric Stimulation; D004569:Electroencephalography / Q000187:drug effects; D005071:Evoked Potentials / Q000187:drug effects; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D009132:Muscles / Q000502:physiology; D011930:Reaction Time / Q000187:drug effects
chemical_list: D001418:Baclofen