title: Effectiveness of curosurf for severe respiratory distress syndrome: a case-control study.
abstract: Randomized trials have proven that exogenous surfactant is effective in severe neonatal respiratory distress syndrome when strict entry criteria are applied. To evaluate efficacy of surfactant treatment in a clinical setting, we performed a case-control study. The outcome of the first 25 consecutive cases treated with porcine surfactant (Curosurf) was compared to that of 25 matched historical nontreated controls. Survival at discharge was significantly higher in surfactant-treated cases than among controls (76 vs. 48%; p less than 0.05). No differences were found in other outcome parameters.
authors.affiliation: Departamento de Pediatria, Hospital de Cruces, Universidad del País Vasco, Bilbao, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Valls-i-Soler
authors.forename: M
authors.initials: M
authors.lastname: Lizarraga
authors.forename: J
authors.initials: J
authors.lastname: López de Heredia
authors.forename: L
authors.initials: L
authors.lastname: Roman
authors.forename: E
authors.initials: E
authors.lastname: Hernáez
authors.forename: E
authors.initials: E
authors.lastname: Gastiasoro
mesh_terms: D001688:Biological Products; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D010743:Phospholipids; D011663:Pulmonary Surfactants / Q000627:therapeutic use*; D012127:Respiratory Distress Syndrome, Newborn / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D016896:Treatment Outcome
chemical_list: D001688:Biological Products; D010743:Phospholipids; D011663:Pulmonary Surfactants; C068291:poractant alfa