Cognitive test performances related to early and late computed tomography findings after closed-head injury.
Computed tomography (CT) findings from early (less than 24 hours) and late scan (6 months) after closed-head injury (CHI) were compared to cognitive test scores obtained on an average of 4 months after injury in a consecutive series of 53 patients. The presence of parenchymal lesion was associated with poor test results, indicating cognitive inflexibility and disinhibition of routine response tendencies in novel tasks. These deficits have previously been found to be related in particular to frontal-lobe dysfunction, but the present study did not support the hypothesis that frontal lesion is the principal cause of this impairment in CHI. Parenchymal lesions in the right and left hemisphere were associated with spatial and verbal deficits, respectively. Ventricular enlargement in the late CT was related to cognitive inefficiency, both being strongly associated with age. The results suggest that parenchymal lesion in the early CT is an indicator of diffuse axonal injury, which results in cognitive inflexibility during recovery.
Vilkki
J
J
Department of Neurosurgery, University Central Hospital, Helsinki, Finland.
Holst
P
P
Ohman
J
J
Servo
A
A
Heiskanen
O
O
D000293:Adolescent; D000328:Adult; D000368:Aged; D003071:Cognition / Q000502:physiology*; D004311:Double-Blind Method; D016489:Head Injuries, Closed / Q000000981:diagnostic imaging / Q000523:psychology*; D006406:Hematoma / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D007361:Intelligence Tests; D008568:Memory / Q000502:physiology; D008875:Middle Aged; D011597:Psychomotor Performance / Q000502:physiology; D014057:Tomography, X-Ray Computed