Electrochemistry of anticonvulsants: electron transfer as a possible mode of action.
Reduction potentials were determined for various anticonvulsants, including progabide, SL 75.102, CGS 9896, pyridazines, zonisamide, 1,2,3-triazoles, and copper complexes. The values generally were in the range of about -0.1 to -0.6 V for the protonated drugs and the metal complexes. Reduction potentials provide information on the feasibility of electron transfer (ET) in vivo. If the value is relatively positive (greater than about -0.6 V), the agent can act catalytically as an electron acceptor from an appropriate cellular donor. A concomitant favorable influence on abnormal neuronal processes associated with epilepsy could occur. We describe ET as a possible mode of action of anticonvulsants as well as some antiepileptic agents with no electrochemical data based on this hypothetical ET approach.
Ames
J R
JR
Department of Chemistry, University of Michigan-Flint 48502-2186.
Kovacic
P
P
Kadaba
P K
PK
Kiser
P F
PF
D000927:Anticonvulsants / Q000494:pharmacology*; D001463:Barbiturates / Q000494:pharmacology; D001569:Benzodiazepines / Q000494:pharmacology; D004563:Electrochemistry; D006801:Humans; D006827:Hydantoins / Q000494:pharmacology; D007555:Isoxazoles / Q000494:pharmacology; D011720:Pyrazoles / Q000494:pharmacology; D012545:Schiff Bases / Q000494:pharmacology; D014230:Triazoles / Q000494:pharmacology; D000078305:Zonisamide; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000494:pharmacology
D000927:Anticonvulsants; D001463:Barbiturates; D006827:Hydantoins; D007555:Isoxazoles; D011720:Pyrazoles; D012545:Schiff Bases; D014230:Triazoles; D001569:Benzodiazepines; C017985:progabide; D000078305:Zonisamide; D005680:gamma-Aminobutyric Acid; C034704:2-(4-chlorophenyl)-2,5-dihydropyrazolo(4,3-c)quinoline-3(3H)-one