[The activity of tumor necrosis factor in schistosomiasis japonica].
The activity of tumor necrosis factor (TNF) in both the culture supernatant of peripheral blood mononuclear cells (PBMC) and the serum was examined in 20 patients of advanced schistosomiasis at 8th week after pyquiton treatment, and 6 rabbits infected with S. japonicum cercariae at 8th and 16th weeks post-infection and using L929 cell cytotoxic assay. The results showed that the capacity of PBMC to produce TNF in response to LPS from patients with late schistosomiasis was significantly lower than that from normal subjects (P less than 0.01), whereas the activity of TNF in serum was significantly elevated (P less than 0.01). The capacity of PBMC to produce TNF and the TNF activity in serum of infected rabbits showed sharp rise at 8th week post-infection (P less than 0.01), and remained high at 16th week, then returned to normal level 8 weeks after treatment. The persistent rise of TNF in the circulation indicate that TNF might take part in the formation of hepatic fibrosis.
Zhang
L W
LW
Institute of Infectious Diseases, Zhejiang Medical University, Hangzhou.
Sun
Y L
YL
Cai
W M
WM
Wang
M H
MH
He
N X
NX
D000328:Adult; D000368:Aged; D000818:Animals; D005260:Female; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011223:Praziquantel / Q000627:therapeutic use; D011817:Rabbits; D012554:Schistosomiasis japonica / Q000097:blood* / Q000188:drug therapy; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis* / Q000502:physiology
D014409:Tumor Necrosis Factor-alpha; D011223:Praziquantel