title: Distribution of proline-specific aminopeptidases in human tissues and body fluids.
abstract: The proline-specific peptidases, aminopeptidase P (EC 3.4.11.9) and dipeptidyl peptidase IV (EC 3.4.14.5), were measured in human tissue homogenates and physiological fluids. All tissues examined contained measurable aminopeptidase P and dipeptidyl peptidase IV activities. High specific activities for both enzymes under study were found in benign prostatic hypertrophy. Normal prostate and prostatic adenocarcinoma had a much lower activity. This difference, however, is not reflected in the serum values of the patients. The most striking finding is the extremely high activity of dipeptidyl peptidase IV in prostatosomes, prostate-derived organelles, which occur freely in human seminal plasma, and which are important for enhancement of sperm forward motility.
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, University of Antwerp, Wilrijk, Belgium.
authors.forename: G
authors.initials: G
authors.lastname: Vanhoof
authors.forename: I
authors.initials: I
authors.lastname: De Meester
authors.forename: M
authors.initials: M
authors.lastname: van Sande
authors.forename: S
authors.initials: S
authors.lastname: Scharpé
authors.forename: A
authors.initials: A
authors.lastname: Yaron
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology; D000626:Aminopeptidases / Q000378:metabolism*; D001826:Body Fluids / Q000201:enzymology*; D018819:Dipeptidyl Peptidase 4; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000378:metabolism*; D006801:Humans; D008297:Male; D011467:Prostate / Q000201:enzymology; D011470:Prostatic Hyperplasia / Q000201:enzymology; D011471:Prostatic Neoplasms / Q000201:enzymology; D014020:Tissue Extracts
chemical_list: D014020:Tissue Extracts; D000626:Aminopeptidases; C022750:X-Pro aminopeptidase; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D018819:Dipeptidyl Peptidase 4