Total cholesterol, high-density lipoprotein cholesterol, and triglycerides in children receiving antiepileptic drugs.
The influence of antiepileptic drug (AED) therapy on total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, and triglycerides was studied in 208 epileptic children compared with 175 normal children. A significant increase in TC plasma levels was observed with carbamazepine (CBZ), phenobarbital (PB), and phenytoin (PHT). The patients receiving valproate (VPA) showed levels very similar to those of the control population. The results may be explainable by the different biotransformation pathway of these drugs. HDL cholesterol and triglycerides were not altered by any of the AEDs. We recommend monitoring TC level in patients receiving CBZ, PB, and PHT and prescription of diet treatment, at least during the time of AED treatment.
Franzoni
E
E
Center of Pediatric Neurology, University of Bologna, Italy.
Govoni
M
M
D'Addato
S
S
Gualandi
S
S
Sangiorgi
Z
Z
Descovich
G C
GC
Salvioli
G P
GP
D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D002220:Carbamazepine / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood*; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D007223:Infant; D010424:Pentobarbital / Q000009:adverse effects / Q000627:therapeutic use; D010672:Phenytoin / Q000009:adverse effects / Q000627:therapeutic use; D014280:Triglycerides / Q000097:blood*; D014635:Valproic Acid / Q000009:adverse effects / Q000627:therapeutic use
D000927:Anticonvulsants; D008076:Cholesterol, HDL; D014280:Triglycerides; D002220:Carbamazepine; D014635:Valproic Acid; D010672:Phenytoin; D002784:Cholesterol; D010424:Pentobarbital