Synthesis and preliminary characterisation of new esters of the bacterial polysaccharide gellan.
Under the appropriate experimental conditions, ethyl, propyl, and methylprednisolon-21-yl esters of gellan can be obtained without significant degradation. At low degrees of esterification (de), depending on the ester moiety, the products are water-soluble, which allows the influence of hydrophilicity and charge density on their ability to assume an ordered conformation in dilute aqueous solution to be studied. With high de, the products were soluble only in organic solvents (e.g., methyl sulphoxide) with good film-forming capacity. The methylprednisolon-21-yl esters have been characterised in a preliminary manner in terms of drug-release kinetics.
Crescenzi
V
V
Department of Chemistry, University of Rome La Sapienza, Italy.
Dentini
M
M
Segatori
M
M
Tiblandi
C
C
Callegaro
L
L
Benedetti
L
L
D000438:Alcohols; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D004952:Esters; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D009904:Optical Rotation; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D012542:Scattering, Radiation; D013055:Spectrophotometry, Infrared; D013816:Thermodynamics
D000438:Alcohols; D004952:Esters; D011135:Polysaccharides, Bacterial; C048288:gellan gum