12-O-tetradecanoylphorbol 13-acetate induced differentiation in human lung squamous carcinoma cells.
Three human lung squamous carcinoma cell lines (NX002, CX140 and CX143) demonstrate features of squamous differentiation including involucrin synthesis and competence to form cornified envelopes. 12-O-Tetradecanoylphorbol 13-acetate inhibits growth of these cell lines and this growth inhibition is associated with enhanced differentiation.
Rabiasz
G J
GJ
ICRF Medical Oncology Unit, Western General Hospital, Edinburgh, UK.
Langdon
S P
SP
Anderson
L
L
Ritchie
A A
AA
Miller
W R
WR
Smyth
J F
JF
D000951:Antigens, Neoplasm / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000276:immunology / Q000473:pathology*; D002454:Cell Differentiation / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D007633:Keratins / Q000032:analysis; D008175:Lung Neoplasms / Q000737:chemistry / Q000276:immunology / Q000473:pathology*; D011498:Protein Precursors / Q000032:analysis*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000951:Antigens, Neoplasm; D011498:Protein Precursors; C032253:involucrin; D007633:Keratins; D013755:Tetradecanoylphorbol Acetate