Di-iodo-L-tyrosine-labelled dextrans as molecular size markers of nasal absorption in the rat.
A series of fractionated di-iodo-L-tyrosine-labelled dextrans (DIT dextrans), with a narrow range of number average molecular weights from 1260 to 45,500 Da, was administered intranasally and intravenously to anaesthetized rats. The nasal absorption of these compounds ranged from 0.6 to 52.7%. There was an inverse relationship between molecular size and the proportion of an intranasal dose absorbed. The study demonstrated the usefulness of DIT dextrans as molecular weight markers and confirmed the relationship between molecular size and nasal absorption for highly water soluble compounds. These results also supported the proposition that there is a continuous range of aqueous pores in the nasal mucosa.
Fisher
A N
AN
Department of Pharmaceutical Sciences, University of Nottingham, UK.
Illum
L
L
Davis
S S
SS
Schacht
E H
EH
D000281:Administration, Intranasal; D000818:Animals; D001692:Biological Transport; D003911:Dextrans / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004105:Diiodotyrosine / Q000031:analogs & derivatives*; D007275:Injections, Intravenous; D008297:Male; D008970:Molecular Weight; D009297:Nasal Mucosa / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D003911:Dextrans; D004105:Diiodotyrosine