Gonadoblastoma and fertility.
Most patients with gonadoblastoma have dysgenetic gonads. This rare tumour has been described in three pregnant women. A fourth case in a 26 year old pregnant woman who presented with gonadoblastoma and dysgerminoma, is reported. She had a normal term pregnancy, 46XX chromosomes, normal genitalia, no history of menstrual irregularities and no signs of hyperandrogenism, thereby differing from the other reported cases. The germ cell component of this patient's tumour had undergone rapid overgrowth, most of the tumour comprising pure dysgerminoma. It is suggested that gonadoblastoma may occur in functionally and morphologically normal gonads more often than previous case reports imply.
Erhan
Y
Y
Obstetrics and Gynaecology Department, Ege University Medical Faculty, Bornova, Turkey.
Toprak
A S
AS
Ozdemir
N
N
Tiras
B
B
D000328:Adult; D004407:Dysgerminoma / Q000473:pathology*; D005260:Female; D005298:Fertility; D006801:Humans; D010051:Ovarian Neoplasms / Q000473:pathology*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology*