Ageing and photoageing of the skin: observations at the cellular and molecular level.
It is now well established that ageing occurs at the level of individual cells in the skin and other organ systems. Changes in cell behaviour, protein production and gene expression in response to standardized stimuli are readily observed in cultured cells derived from young vs old donors and from photoaged vs sun-protected body sites. Whether these changes are best viewed as a cause or a consequence of ageing cannot be determined at present. Nevertheless, available data now provide cellular and molecular correlates for the well-known differences in clinical responsiveness between newborn, adult and photoaged skin. From this basis, it will hopefully be possible to develop a more comprehensive understanding of cutaneous ageing processes.
Gilchrest
B A
BA
USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA.
Yaar
M
M
D000328:Adult; D000368:Aged; D002454:Cell Differentiation; D002478:Cells, Cultured; D066246:ErbB Receptors / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D015603:Keratinocytes / Q000473:pathology; D008938:Mitosis; D011519:Proto-Oncogenes / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism; D012867:Skin / Q000473:pathology; D015595:Skin Aging / Q000473:pathology / Q000502:physiology*; D013472:Sunlight / Q000009:adverse effects*
D012333:RNA, Messenger; D066246:ErbB Receptors