[Effect of serum from IgA nephropathy patients on IL-1 production from P388 D1 cell lines].
The study was designed to investigate IL-1 production from P388D1 cell using serum from 40 cases with IgA nephropathy (IgAN) as stimulative factor. It was found that there was a relationship between IL-1 and renal morphological change. The result indicated that IL-1 production by P388D1 cell was much higher in the presence of the serum than that in the absence (CPM: 47597 +/- 26213 vs 36567 +/- 14377 P less than 0.05). The level of IL-1 correlated obviously to the renal morphologic changes (r = 0.406, P less than 0.05). It is suggested that in the serum of IgAN patients there are certain factors stimulating P388D1 cell to produce IL-1, which may contribute to the pathogenesis of IgAN.
Chen
X M
XM
Dept. of Nephrology, General Hospital of Chinese PLA, Beijing.
Yu
L F
LF
Cheng
Q L
QL
D000293:Adolescent; D000328:Adult; D000818:Animals; D002478:Cells, Cultured / Q000378:metabolism; D005260:Female; D005922:Glomerulonephritis, IGA / Q000097:blood* / Q000209:etiology / Q000473:pathology; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis*; D007668:Kidney / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D013950:Thymus Gland / Q000166:cytology
D007375:Interleukin-1