title: Novel adjuvant action of lipopolysaccharides that possess mannose homopolysaccharides as O-specific polysaccharides on immune responses to nonimmunogenic autoantigens in mice.
abstract: The adjuvant action of various lipopolysaccharides on immune responses to syngeneic tissue extract in mice was examined. Only lipopolysaccharides possessing the linear mannose homopolysaccharides as O-specific polysaccharides exhibited definite adjuvant action on immune responses to the autoantigens. The intensity of this adjuvant activity of lipopolysaccharide from Klebsiella O3 seemed to be the strongest.
authors.affiliation: Department of Microbiology, Aichi Medical University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yokochi
authors.forename: M
authors.initials: M
authors.lastname: Fukada
authors.forename: M
authors.initials: M
authors.lastname: Kawai
authors.forename: Y H
authors.initials: YH
authors.lastname: Zhang
authors.forename: G Z
authors.initials: GZ
authors.lastname: Jiang
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D002240:Carbohydrate Sequence; D004926:Escherichia coli / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007709:Klebsiella / Q000276:immunology; D008070:Lipopolysaccharides / Q000737:chemistry / Q000276:immunology*; D008297:Male; D008362:Mannosides / Q000276:immunology; D051379:Mice; D008969:Molecular Sequence Data; D019081:O Antigens; D009920:Orchitis / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D012475:Salmonella / Q000276:immunology; D013737:Testis / Q000276:immunology; D013961:Thyroid Gland / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000276:immunology*
chemical_list: D000942:Antigens, Bacterial; D001324:Autoantigens; D008070:Lipopolysaccharides; D008362:Mannosides; D019081:O Antigens; D011135:Polysaccharides, Bacterial