title: Response of pulpal blood flow to intra-arterial infusion of endothelin.
abstract: Laser Doppler flowmetry was used to determine the effect of the vasoconstrictor endothelin 1 (ET-1) on the pulpal blood flow of intact dogs' teeth during mandibular arterial infusion. ET-1 produced a profound decrease in pulpal blood flow of a relatively long duration at lower doses than similar infusions of norepinephrine. The decrease in pulpal blood flow in response to ET-1 was partially attenuated by the calcium channel blocker nifedipine. These findings demonstrate the presence of receptors for ET-1 in the microvasculature of the dental pulp and suggests that ET-1 may function in the local control of the pulpal microcirculation.
authors.forename: T M
authors.initials: TM
authors.lastname: Gilbert
authors.forename: D H
authors.initials: DH
authors.lastname: Pashley
authors.forename: R W
authors.initials: RW
authors.lastname: Anderson
mesh_terms: D000818:Animals; D003782:Dental Pulp / Q000098:blood supply* / Q000187:drug effects*; D004285:Dogs; D016232:Endothelins / Q000494:pharmacology*; D017078:Laser-Doppler Flowmetry; D008833:Microcirculation / Q000187:drug effects*; D012039:Regional Blood Flow / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000494:pharmacology
chemical_list: D016232:Endothelins; D014662:Vasoconstrictor Agents