Syntheses of a glycerophospholipid, C16-platelet activating factor and a palmitoyl analogue of M-5, an anti-inflammatory glyceroglycolipid.
From a chiral C4-epoxide (-)-3, which is one of the synthons in our synthetic strategy for complex lipids, a glycerophospholipid C16-platelet activating factor (C16-PAF, 1) and a palmitoyl analogue (2) of an anti-inflammatory glyceroglycolipid M-5, which was previously isolated from the Okinawan marine sponge Phyllospongia foliascens, have been synthesized.
Shibuya
H
H
Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Kawashima
K
K
Narita
N
N
Kitagawa
I
I
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D005994:Glycerophosphates / Q000138:chemical synthesis*; D006017:Glycolipids / Q000138:chemical synthesis*; D010169:Palmitic Acids / Q000138:chemical synthesis*; D010743:Phospholipids / Q000138:chemical synthesis*; D010972:Platelet Activating Factor / Q000138:chemical synthesis*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005994:Glycerophosphates; D006017:Glycolipids; D010169:Palmitic Acids; D010743:Phospholipids; D010972:Platelet Activating Factor; C016476:glyceroglucolipids