Microbial transformation of immunosuppressive compounds. II. Specific desmethylation of 13-methoxy group of FK 506 and FR 900520 by an unidentified Actinomycete ATCC 53828 [corrected].
Chen
T S
TS
Merck Sharp & Dohme Research Laboratory, Rahway, New Jersey 07065.
Arison
B H
BH
Wicker
L S
LS
Inamine
E S
ES
D000190:Actinomyces / Q000737:chemistry / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D010880:Piperidines / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013601:T-Lymphocytes / Q000187:drug effects; D016559:Tacrolimus / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents; D010880:Piperidines; C074832:L 685487; C074833:L 683519; C058028:immunomycin; D016559:Tacrolimus