title: Increased secretion of interleukin-6 in malignant mesothelioma cells from a patient with marked thrombocytosis.
abstract: BACKGROUND
  A high prevalence of thrombocytosis in malignant mesothelioma has been reported, although its pathogenesis remains unknown.
  
  
  METHODS
  The case of a patient with marked thrombocytosis in peritoneal malignant mesothelioma is reported. To investigate the cytokines responsible for thrombocytosis in this patient, enzyme-linked immunosorbent assay and immunohistochemical analysis were used.
  
  
  RESULTS
  Tumor cells produced large amounts of interleukin-6 (IL-6) and small amounts of granulocyte macrophage colony stimulating factor (GM-CSF) and monocyte colony stimulating factor (M-CSF). Immunocytochemical staining of tumor cells showed strong positivity for IL-6.
  
  
  CONCLUSIONS
  These results indicated that persistent secretion of IL-6 promoted thrombogenesis in this patient.
authors.affiliation: First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Higashihara
authors.forename: S
authors.initials: S
authors.lastname: Sunaga
authors.forename: T
authors.initials: T
authors.lastname: Tange
authors.forename: H
authors.initials: H
authors.lastname: Oohashi
authors.forename: K
authors.initials: K
authors.lastname: Kurokawa
mesh_terms: D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D008297:Male; D008654:Mesothelioma / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D013922:Thrombocytosis / Q000209:etiology*
chemical_list: D015850:Interleukin-6