title: Bone response to invading tumors with spindle cell components: a report of findings in two patients.
abstract: Two case studies are presented in which quantitative bone histomorphometry is used to analyze bone changes in adult patients with diagnosed spindle cell sarcoma. Three tumor-involved sites and one noninvolved site from the iliac crest of patient 1 were evaluated. In the involved sites the percentage trabecular bone volume (11.0%) and the number of osteoblasts (0.6 cell/mm2) were significantly reduced, osteoid volume was significantly increased (8.1%), and woven osteoid was present. The total eroded surface (6.8%) was also significantly increased. In the noninvolved site the number of osteoblasts was decreased and both the percentage eroded and percentage osteoclast surfaces were increased. In the femoral epicondyle specimen from patient 2 the number of osteoblasts was 27.0 cells/mm2, percentage osteoid volume was 18.4%, percentage osteoid surface was 62.9%, and osteoid thickness was 20.0 microns. In tumor-involved sites in both patients indices of active bone resorption were similar and normal. These two case studies indicate that (1) distinctive morphologic changes occur in bone invaded by spindle cell sarcoma, and that (2) changes affect bone formation to a greater extent than bone resorption. Bone alterations are probably local in nature and related to the extent and duration of tumor invasion and the influence of local tumor factor(s).
authors.affiliation: Medical Genetics-Birth Defects Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
authors.forename: H E
authors.initials: HE
authors.lastname: Gruber
authors.forename: C P
authors.initials: CP
authors.lastname: Schwinn
authors.forename: M E
authors.initials: ME
authors.lastname: Kirchen
authors.forename: T M
authors.initials: TM
authors.lastname: Moore
authors.forename: G J
authors.initials: GJ
authors.lastname: Marshall
mesh_terms: D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D001862:Bone Resorption; D001842:Bone and Bones / Q000473:pathology* / Q000648:ultrastructure; D002452:Cell Count; D005260:Female; D005269:Femur / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D007085:Ilium / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D010006:Osteoblasts / Q000473:pathology; D010010:Osteoclasts / Q000473:pathology; D012509:Sarcoma / Q000473:pathology* / Q000648:ultrastructure