Effects of cyclopiazonic acid, an inhibitor of the Ca++ ATPase of sarcoplasmic reticulum, on Ca++ transport, contraction and relaxation in cardiac muscle.
Cyclopiazonic acid is a potent inhibitor of cardiac sarcoplasmic reticulum Ca++ ATPase. It scarely affects inotropism but significantly impairs lusitropism suggesting a greater role for cardiac sarcoplasmic reticulum in the control of cardiac relaxation than in the control of cardiac contraction.
Lahouratate
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P
SmithKline Beecham Laboratoires Pharmaceutiques, St. Gregoire, France.
Quiniou
M J
MJ
Léoty
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C
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors*; D004285:Dogs; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology*; D009183:Mycotoxins / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects*; D009210:Myofibrils / Q000187:drug effects / Q000502:physiology; D010210:Papillary Muscles / Q000187:drug effects / Q000502:physiology*; D011817:Rabbits; D012519:Sarcoplasmic Reticulum / Q000201:enzymology*
D007211:Indoles; D009183:Mycotoxins; D000252:Calcium-Transporting ATPases; D002118:Calcium; C000543:cyclopiazonic acid