8-OH-DPAT-induced inhibition of renal sympathetic nerve activity and serotonin neuronal firing.
The effects of the 5-HT1A receptor 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) administered i.v. on medullary 5-HT neuronal firing and renal sympathetic nerve activity were determined in spontaneously breathing anaesthetized cats. Low doses of 8-OH-DPAT (1-3 micrograms/kg) caused a similar reduction in 5-HT neuronal firing and renal nerve activity while high doses (10-30 micrograms/kg) completely inhibited neuronal firing but caused only 80% inhibition of renal nerve activity. These data are discussed in relationship to the mechanism of sympatholytic action of 8-OH-DPAT and the serotonergic regulation of sympathetic nerve activity.
Ramage
A G
AG
Cardiovascular Disease Research, Upjohn Company, Kalamazoo, MI 49001.
Clement
M E
ME
McCall
R B
RB
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000294:innervation*; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D012701:Serotonin / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000187:drug effects*
D012701:Serotonin; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin