Effects of oxazolidines derived from (-) ephedrine in the rat.
1. Five oxazolidines were synthesized by reaction of (-) ephedrine with aliphatic aldehydes. The aldehydes used were formaldehyde, propionaldehyde, butyraldehyde, isobutyraldehyde and trimethylacetaldehye. 2. These five oxazolidines were tested in rats for ephedrine-like pharmacological activity using the hyperthermia and anorexia models. 3. All five oxazolidines caused significant elevation of body temperature in the hyperthermia model. The oxazolidine synthesized from (-) ephedrine and butyraldehyde caused greatest hyperthermia. 4. Four oxazolidines caused significant anorectic responses. The oxazolidine synthesized from (-) ephedrine and isobutyraldehyde caused greatest anorexia. 5. A possible tolerance to the anorectic effects of some of the compounds was observed.
Walker
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RB
Chemistry Department, University of Arkansas, Pine Bluff 71601.
Wood
D M
DM
Akmal
M M
MM
Sharks
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E
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D004435:Eating / Q000187:drug effects; D004809:Ephedrine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008297:Male; D010080:Oxazoles / Q000494:pharmacology*; D011355:Prodrugs; D051381:Rats; D017207:Rats, Sprague-Dawley
D010080:Oxazoles; D011355:Prodrugs; D004809:Ephedrine