Electric and/or magnetic field effects on DNA structure and function in cultured human cells.
Exposure of cultured K562 cells to 50 Hz electric (0.2-20 kV/m), magnetic (0.002-2 G), or combined electric and magnetic fields for up to 24 h did not result in the production of detectable DNA lesions, as assayed by the filter elution technique. The rate of cell growth was also unaffected as well as the intracellular ATP and NAD+ levels. These results indicate that, under the experimental conditions utilized in this study, 50 Hz electric, magnetic and electromagnetic fields are not geno- and cyto-toxic in cultured mammalian cells.
Fiorani
M
M
Centro di Metodologie Biochimiche Applicate, Università degli Studi di Urbino, Italy.
Cantoni
O
O
Sestili
P
P
Conti
R
R
Nicolini
P
P
Vetrano
F
F
Dachà
M
M
D000255:Adenosine Triphosphate / Q000378:metabolism; D002455:Cell Division / Q000528:radiation effects; D004247:DNA / Q000528:radiation effects*; D004249:DNA Damage; D004574:Electromagnetic Fields / Q000009:adverse effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008741:Methyl Methanesulfonate / Q000633:toxicity; D009243:NAD / Q000378:metabolism; D014407:Tumor Cells, Cultured
D009243:NAD; D000255:Adenosine Triphosphate; D004247:DNA; D008741:Methyl Methanesulfonate