Hyperfractionated radiotherapy and polychemotherapy in brain stem tumors in children.
Between October 1989 and January 1991 five children with brain stem tumors were treated with sequential chemo- and radiotherapy. The polychemotherapy consisted of procarbazine, ifosfamide, etoposide, methotrexate, cisplatin and cytosine arabinoside. Locally, hyperfractionated radiotherapy was delivered at a total dose of 63.8 Gy (1.1 Gy twice daily, 10 fractions per week). After a median observation time of 11.8 (range 4-23) months from diagnosis three children are alive and without evidence of tumor progression. Two patients died from tumor progression 11 and 16 months respectively after initiation of therapy.
Pakisch
B
B
Abteilung für Strahlentherapie, Radiologische Universitätsklinik, Graz, Austria.
Urban
C
C
Slavc
I
I
Poier
E
E
Stücklschweiger
G
G
Oberbauer
R
R
Mokry
M
M
Poschauko
J
J
Hammer
J
J
Leitner
H
H
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003561:Cytarabine / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D011149:Pons; D011855:Radiodermatitis / Q000209:etiology; D011879:Radiotherapy Dosage; D012074:Remission Induction; D015996:Survival Rate; D013788:Thalamus
D003561:Cytarabine; D008727:Methotrexate