[CSF monoamine metabolites in patients with progressive supranuclear palsy].
Neurochemical abnormalities in the patients with progressive supranuclear palsy (PSP) are not well understood. We investigated CSF levels of the monoamine metabolites HVA, 5HIAA and MHPG in 5 patients with PSP in order to investigate, especially dopaminergic, serotonergic and noradrenergic metabolism. Results were as follows (value; mena +/- S.D.). [table: see text] The levels of HVA were significantly lower than those in controls. These findings suggest that there is a hypofunction of dopaminergic neurons in PSP patients.
Yamamoto
M
M
Department of Neurology, Kagawa Central Hospital.
Ujike
H
H
Kohira
I
I
Ogasawara
N
N
Ogawa
N
N
D000368:Aged; D015306:Biogenic Monoamines / Q000134:cerebrospinal fluid* / Q000378:metabolism; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000134:cerebrospinal fluid; D008875:Middle Aged; D013494:Supranuclear Palsy, Progressive / Q000134:cerebrospinal fluid*
D015306:Biogenic Monoamines; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D006719:Homovanillic Acid