Synthesis and antitumor activity of fused quinoline derivatives. III. Novel N-glycosylamino-indolo[3,2-b]quinolines.
Novel indolo[3,2-b]quinolines (1b-k), having a nitro, amino, acetamido, methanesulfonamido, or glycosylamino group at the 2, 7, or 8-position, were prepared and their antitumor activities against P388 leukemia in mice were examined. The 7-galactopyranosylamino derivative (1g) showed the most potent activity (optimal dose = 25 mg/kg, T/C greater than 333%, cure rate 5/6).
Takeuchi
Y
Y
Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Chang
M R
MR
Hashigaki
K
K
Tashiro
T
T
Tsuruo
T
T
Tsukagoshi
S
S
Yamato
M
M
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology*; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D011804:Quinolines / Q000138:chemical synthesis / Q000494:pharmacology*
D000970:Antineoplastic Agents; D007211:Indoles; D011804:Quinolines