title: Human liver glutamic gamma-semialdehyde dehydrogenase: structural relationship to the yeast enzyme.
abstract: The amino acid sequences of nine tryptic peptides (containing altogether 105 amino acids) from human liver glutamic gamma-semialdehyde of dehydrogenase (hitherto designated as ALDH4) were found to correspond, at 33-66% identity, to segments from the yeast 1-proline-5-carboxylate (P5C) dehydrogenase encoded by the PUT2 gene.
authors.affiliation: Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, PA 15261.
authors.forename: J
authors.initials: J
authors.lastname: Hempel
authors.forename: R
authors.initials: R
authors.lastname: Eckey
authors.forename: D
authors.initials: D
authors.lastname: Berie
authors.forename: H
authors.initials: H
authors.lastname: Romovacek
authors.forename: D P
authors.initials: DP
authors.lastname: Agarwal
authors.forename: H W
authors.initials: HW
authors.lastname: Goedde
mesh_terms: D050842:1-Pyrroline-5-Carboxylate Dehydrogenase; D000595:Amino Acid Sequence; D006801:Humans; D008099:Liver / Q000201:enzymology*; D008969:Molecular Sequence Data; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000737:chemistry*; D010455:Peptides / Q000032:analysis; D012441:Saccharomyces cerevisiae / Q000201:enzymology*; D029701:Saccharomyces cerevisiae Proteins; D017385:Sequence Homology
chemical_list: D010455:Peptides; D029701:Saccharomyces cerevisiae Proteins; D050842:1-Pyrroline-5-Carboxylate Dehydrogenase; C494240:ALDH4A1 protein, human; C494242:PUT2 protein, S cerevisiae; D000587:Oxidoreductases Acting on CH-NH Group Donors