Cutaneous lymphadenoma with focal mucinosis.
Cutaneous lymphadenoma of the eyebrow occurred in a 72-year-old man. The nodular tumor was well circumscribed but non encapsulated and invaded the reticular dermis and superficial hypodermis without any connection with the epidermis. Tumor cells had a basal-like appearance and were arranged in small lobules and islands with peripheral palisading and areas of central keratinization. They were often dissociated by an extracellular mucinous material. The stroma was fibroblastic and contained a marked lymphoid infiltrate that surrounded and penetrated the neoplastic lobules. Occasional germ-like hair follicle structures were noted. The immunohistochemical pattern was similar to that of hair follicles, and the leucocytic component was predominantly composed of T-lymphocytes and Langerhans cells, which were specially numerous within the neoplastic lobules. We believe that the tumor, in the present case, has morphologic features consistent with epithelial and stromal attributes observed in hair follicles.
Wechsler
J
J
Department of cells & Tissue Pathology, Henri Mondor Hospital, Créteil, France.
Fromont
G
G
André
J M
JM
Zafrani
E S
ES
D000368:Aged; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008223:Lymphoma / Q000150:complications* / Q000473:pathology; D008297:Male; D009077:Mucins / Q000378:metabolism*; D012871:Skin Diseases / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology; D013194:Staining and Labeling
D009077:Mucins