Is injectable collagen truly safe?
Most patients have no response to injectable collagen or silicone, but some cases may have positive or 'undersea' (= clinically negative but immunologically positive) response to collagen. From the results of the Macrophage migration inhibition test, the relative immunogenicity was augmented most when we used implants with the following combination. The first immunization was collagen and the second one was collagen with silicone. The augmented antigenicity might be enough to cause an allergic reaction to the patients who had no response to each implant alone.
Takayama
E
E
Department of Otolaryngology, National Defense Medical College, Saitama, Japan.
Ikeda
M
M
Tsuru
S
S
Ogura
M
M
Kitahara
S
S
Inouye
T
T
Healy
G B
GB
D000276:Adjuvants, Immunologic; D000818:Animals; D002464:Cell Migration Inhibition; D003094:Collagen / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007267:Injections; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D012828:Silicones / Q000009:adverse effects*; D014827:Vocal Cords
D000276:Adjuvants, Immunologic; D012828:Silicones; D003094:Collagen