title: [Detection of circulating activated platelets by anti-GMP-140 monoclonal antibodies].
abstract: The clinical significance and detection methods for circulating activated platelets are reviewed. It has been recently demonstrated that three kinds of platelet granules, dense granule, alpha-granule and lysosome, have specific membrane proteins; granulophysin, GMP-140 (PADGEM) and CD63 antigen, respectively, and that these specific granule-membrane proteins become exposed on the surface of the activated platelets. It is believed that detection of circulating activated platelets, using monoclonal antibodies specific to these granule-membrane, may be reliable and diagnostic value in thrombotic and prethrombotic diseases. Preliminary clinical studies using 2T60, a newly developed anti-GMP-140 monoclonal antibody, was presented.
authors.affiliation: Dept. of Cardiovascular Res., Tokyo Metropolitan Inst. of Medical Science.
authors.forename: K
authors.initials: K
authors.lastname: Tanoue
authors.forename: N
authors.initials: N
authors.lastname: Akamatsu
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Katagiri
authors.forename: H
authors.initials: H
authors.lastname: Yamazaki
authors.forename: T
authors.initials: T
authors.lastname: Fujimoto
authors.forename: S
authors.initials: S
authors.lastname: Fukuda
authors.forename: Y
authors.initials: Y
authors.lastname: Onozawa
mesh_terms: D000911:Antibodies, Monoclonal; D001665:Binding Sites; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D019007:P-Selectin; D015539:Platelet Activation; D010980:Platelet Membrane Glycoproteins / Q000032:analysis / Q000276:immunology* / Q000378:metabolism; D013927:Thrombosis / Q000175:diagnosis
chemical_list: D000911:Antibodies, Monoclonal; D019007:P-Selectin; D010980:Platelet Membrane Glycoproteins; D005340:Fibrinogen