1 beta-hydroxylated bile acids in the urine of healthy neonates.
In order to clarify the metabolism of bile acids in neonates, 1 beta-hydroxylated bile acids in the urine of healthy newborns were examined by gas chromatography-mass spectrometry. The results showed that the percentage of total 1 beta-hydroxylated bile acids, 3 beta, 12 alpha-dihydroxy-5-cholenoic acid and hyocholic acid in neonates was significantly higher than in older children. The ratio of 1 beta-hydroxylated bile acids to their comparable primary bile acids was also higher in neonates than in older children. These results suggest that 1 beta- and 6 alpha-hydroxylation of bile acids are the predominant pathways of bile acid metabolism in neonates.
Obinata
K
K
Department of Pediatrics, Koshigaya Municipal Hospital, Saitama, Japan.
Nittono
H
H
Yabuta
K
K
Mahara
R
R
Tohma
M
M
D001647:Bile Acids and Salts / Q000378:metabolism / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D006900:Hydroxylation; D007223:Infant; D007231:Infant, Newborn / Q000652:urine*
D001647:Bile Acids and Salts