[Treatment of patients with panic disorder and an elevated urinary excretion of MHPG using imipramine or clonazepam].
The response to treatment with imipramine or clonazepam was evaluated in patients with panic disorder. These patients had a high urinary 3-methoxy-4-hydroxy-phenylglycol 24 h-excretion and normal plasma lactate levels. Both drugs were efficient as anti-panic agents, but clonazepam resulted more efficacious than imipramine by the scores of Hamilton Anxiety or Depression Scales. Moreover, clonazepam also reduced the anticipatory anxiety.
Lima
L
L
Instituto Venezolano de Investigaciones Científicas, Caracas.
Carreira
I
I
Morales
M
M
Silva
C
C
Casique
M
M
D000328:Adult; D001008:Anxiety Disorders / Q000453:epidemiology; D002998:Clonazepam / Q000494:pharmacology / Q000627:therapeutic use*; D003863:Depression / Q000150:complications; D005260:Female; D006801:Humans; D007099:Imipramine / Q000494:pharmacology / Q000627:therapeutic use*; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000652:urine*; D008875:Middle Aged; D009638:Norepinephrine / Q000378:metabolism; D016584:Panic Disorder / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D010259:Paranoid Disorders / Q000150:complications; D015995:Prevalence; D011581:Psychological Tests; D012559:Schizophrenia / Q000150:complications
D007773:Lactates; D019344:Lactic Acid; D008734:Methoxyhydroxyphenylglycol; D002998:Clonazepam; D007099:Imipramine; D009638:Norepinephrine