title: [Rapeseed poisoning of wild herbivores].
abstract: Beginning with the simultaneous occurrence of the first extensive sowing of 00-rape and local increased losses among hares and roe deer in Western Germany and Austria at the end of 1986, the clinical and morphological symptoms of rape poisoning are discussed. They consist of damage to endo- and epithelium, cell membranes, blood, liver and in the so called "rape-blindness". Subsequently, the most important toxic agents of rape including their metabolites are presented. They consist in alkenyl- and indolyl-glucosinolates, leading to isothiocyanates (mustard oils), thiocyanates or thiocyanate ions resp., nitriles and antithyroid agents (e.g. goitrin) as well as S-methylcysteine sulphoxide and its metabolites, particularly dimethyl disulphide. Finally, the activity spectrum of the toxic agents or the metabolites and the clinical picture of the affected wildlife in 1986 are compared with the result that the losses of that period are most likely to be traced back to rape poisoning and that the rape-blindness mentioned is to be interpreted as a thiocyanate-psychosis.
authors.affiliation: Tierärztlichen Fakultät, Universität München, Itingen, Basel.
authors.forename: A
authors.initials: A
authors.lastname: Schmid
authors.forename: H
authors.initials: H
authors.lastname: Schmid
mesh_terms: D000818:Animals; D000835:Animals, Wild; D013956:Antithyroid Agents / Q000032:analysis / Q000506:poisoning; D001317:Austria / Q000453:epidemiology; D001937:Brassica / Q000737:chemistry; D003545:Cysteine / Q000031:analogs & derivatives / Q000032:analysis / Q000506:poisoning; D003670:Deer; D005858:Germany / Q000453:epidemiology; D005961:Glucosinolates / Q000032:analysis / Q000506:poisoning; D017879:Isothiocyanates; D007793:Lagomorpha; D009570:Nitriles / Q000032:analysis / Q000506:poisoning; D010939:Plant Poisoning / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D013455:Sulfur / Q000032:analysis / Q000506:poisoning; D013861:Thiocyanates / Q000032:analysis / Q000506:poisoning
chemical_list: D013956:Antithyroid Agents; D005961:Glucosinolates; D017879:Isothiocyanates; D009570:Nitriles; D013861:Thiocyanates; C037152:isothiocyanic acid; C008389:methiin; D013455:Sulfur; D003545:Cysteine