title: Dehydroepiandrosterone (DHEA) levels in patients with prostatic cancer, heart diseases and under surgery stress.
abstract: DHEA levels in patients with prostatic cancer were significantly lower, but total and free testosterone (T) significantly higher as those in an age-matched control group. Therefore, the calculated quotients DHEA/free T and DHEA/T were especially different between both groups. DHEA and DHEAS levels in patients with heart diseases were also significantly lower but cortisol (F) levels were significantly higher as those in a control group. The quotients DHEA/F and DHEAS/F were also of greater significance between both groups than the hormone values alone. The response of DHEA and F levels in patients undergoing surgery showed an increase of both steroids under surgery. On the second postoperative day, however, F levels were still significantly higher but DHEA levels were significantly lower as the initial values. The differences between the initial values and those on the second postoperative day of F and DHEA showed a significant correlation, i.e. the higher the elevation of F levels above the initial values the greater was the diminution of DHEA levels below the initial values.
authors.affiliation: Department of Urology, Humboldt University Medical School (Charité), Berlin, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Stahl
authors.forename: D
authors.initials: D
authors.lastname: Schnorr
authors.forename: C
authors.initials: C
authors.lastname: Pilz
authors.forename: G
authors.initials: G
authors.lastname: Dörner
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives / Q000097:blood*; D019314:Dehydroepiandrosterone Sulfate; D005260:Female; D006331:Heart Diseases / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008016:Life Change Events; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000097:blood*; D011863:Radioimmunoassay; D013514:Surgical Procedures, Operative / Q000523:psychology*; D013739:Testosterone / Q000097:blood
chemical_list: D013739:Testosterone; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate; D006854:Hydrocortisone