Bordetella bronchiseptica pneumonia and bacteremia following bone marrow transplantation.
Bordetella bronchiseptica is a frequent cause of respiratory infections in animals but rarely causes disease in humans. We describe a patient with B. bronchiseptica pneumonia and bacteremia that developed following bone marrow transplantation. B. bronchiseptica infection persisted despite antimicrobial therapy and may have progressed because of the combined effects of the patient's underlying immunosuppression and the antimicrobial antagonism between doxycycline and ciprofloxacin.
Bauwens
J E
JE
Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.
Spach
D H
DH
Schacker
T W
TW
Mustafa
M M
MM
Bowden
R A
RA
D000328:Adult; D016470:Bacteremia / Q000188:drug therapy / Q000209:etiology; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D001885:Bordetella Infections / Q000188:drug therapy / Q000209:etiology*; D016950:Bordetella bronchiseptica / Q000302:isolation & purification*; D002939:Ciprofloxacin / Q000627:therapeutic use; D004318:Doxycycline / Q000627:therapeutic use; D004336:Drug Antagonism; D005260:Female; D006801:Humans; D011014:Pneumonia / Q000188:drug therapy / Q000209:etiology
D002939:Ciprofloxacin; D004318:Doxycycline