Serotonergic dysfunction in depression associated with Parkinson's disease.
A 55-year-old man presented with a 5-year history of Parkinson's disease and a 6-month history of major depression. The patient's depressive symptoms responded to treatment with fluvoxamine, a selective and potent serotonin reuptake inhibitor. Tryptophan depletion testing, which acutely lowers central serotonin levels, caused a brief exacerbation of the depressive illness, which resolved upon tryptophan repletion. Serotonergic dysfunction may be an etiologic factor in depression that occurs in Parkinson's disease.
McCance-Katz
E F
EF
Connecticut Mental Health Center, Department of Psychiatry, New Haven.
Marek
K L
KL
Price
L H
LH
D003866:Depressive Disorder / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D016666:Fluvoxamine / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D014179:Neurotransmitter Uptake Inhibitors / Q000627:therapeutic use; D010300:Parkinson Disease / Q000378:metabolism* / Q000523:psychology*; D012701:Serotonin / Q000378:metabolism*; D014364:Tryptophan / Q000378:metabolism
D014179:Neurotransmitter Uptake Inhibitors; D012701:Serotonin; D014364:Tryptophan; D016666:Fluvoxamine