Identification of a human brain peptidase with the specificity to generate the N-terminus of A4/beta-amyloid protein from its precursor.
McDermott
J R
JR
MRC Neurochemical Pathology Unit, Newcastle General Hospital.
Biggins
J A
JA
Gibson
A M
AM
D000595:Amino Acid Sequence; D016229:Amyloid beta-Peptides / Q000235:genetics / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism*; D002540:Cerebral Cortex / Q000201:enzymology*; D002852:Chromatography, Ion Exchange; D010450:Endopeptidases / Q000302:isolation & purification / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D011480:Protease Inhibitors / Q000494:pharmacology*; D011499:Protein Processing, Post-Translational; D013379:Substrate Specificity
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D011480:Protease Inhibitors; D010450:Endopeptidases