Synthetic peptides in the search for T- and B-cell epitopes.
In this article, Eva Rajnavölgyi describes two aspects of the rigorous application of organic chemistry to the task of synthesizing peptides that induce immune responses. First, the development of viral peptides that activate T and B cells without the need for carrier molecules and secondly, the production of a new generation of immunologically inert carrier molecules.
Rajnavölgyi
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Dept of Immunology, Lóránd Eötvös University, Hungary.
D000595:Amino Acid Sequence; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002352:Carrier Proteins / Q000276:immunology; D000939:Epitopes / Q000276:immunology*; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014759:Viral Envelope Proteins / Q000276:immunology
D002352:Carrier Proteins; D000939:Epitopes; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral; D010455:Peptides; D014759:Viral Envelope Proteins