[Blood platelet as a test system in the evaluation of neurohormonal imbalance in pregnant women with diabetes mellitus].
A study was made of platelet alpha 2- and beta 2-adrenoreceptors stimulated by adrenaline and alupent as well as of hemostatic system parameters the levels of ACTH, cortisol, glucagon and C-peptide in the blood of women with type I diabetes mellitus during pregnancy, surgical delivery, and the postoperative period. It is shown that the changes in the sensitivity of both subtypes of platelet adrenoreceptors are closely related to the activation of the stress-realizing systems and may serve as a test for estimating the intensity of neurohumoral imbalance both during pregnancy and surgical intervention. The sensitivity of platelet adrenoreceptors to agonists may be examined by a simple retention test allowing rapid information to be derived, which is of paramount importance under clinical conditions.
Kuznetsov
N N
NN
Kulikov
A V
AV
Egorov
V M
VM
Vershinina
G A
GA
Anisimov
K Iu
KIu
Iakushev
A M
AM
D000324:Adrenocorticotropic Hormone / Q000097:blood; D001792:Blood Platelets / Q000187:drug effects*; D002096:C-Peptide / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D005934:Glucagon / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D009921:Metaproterenol / Q000494:pharmacology; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D013268:Stimulation, Chemical
D002096:C-Peptide; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D009921:Metaproterenol; D000324:Adrenocorticotropic Hormone; D005934:Glucagon; D006854:Hydrocortisone; D004837:Epinephrine