Role of serotonin receptor subtype in seizures kindled from the feline hippocampus.
This study assessed the effects of a serotonin (5-HT)1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a 5-HT2 agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and a 5-HT2 antagonist ketanserin on fully kindled seizures from the hippocampus. 8-OH-DPAT produced a marked suppression in hippocampal kindled seizures, while producing behavioral signs similar to those seen in the 5-HT syndrome. Although DOI and ketanserin did not affect kindled focal epileptic activity, DOI shortened and ketanserin prolonged the latency to onset of generalized convulsions. Our data suggest that 5-HT1A receptors play an inhibitory role in the generation of hippocampal seizures, whereas 5-HT2 receptors may participate in kindled seizure generalization from this region.
Wada
Y
Y
Department of Neuropsychiatry, Kanazawa University School of Medicine, Japan.
Nakamura
M
M
Hasegawa
H
H
Yamaguchi
N
N
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000662:Amphetamines / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D002415:Cats; D004558:Electric Stimulation; D005260:Female; D006213:Hallucinogens / Q000494:pharmacology; D006624:Hippocampus / Q000378:metabolism*; D007650:Ketanserin / Q000494:pharmacology; D007696:Kindling, Neurologic / Q000378:metabolism*; D008297:Male; D011985:Receptors, Serotonin / Q000378:metabolism*; D012640:Seizures / Q000378:metabolism*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology
D000662:Amphetamines; D000927:Anticonvulsants; D006213:Hallucinogens; D011985:Receptors, Serotonin; D013764:Tetrahydronaphthalenes; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D007650:Ketanserin; C015952:4-iodo-2,5-dimethoxyphenylisopropylamine