Antibiotic-impregnated plaster of Paris beads. Trials with teicoplanin.
Teicoplanin-impregnated plaster of Paris beads were made and in vitro release properties were studied. Teicoplanin was released in an initial massive dose, with a rapid decline during the first three days, followed by a slowly declining prolonged release up to 30 days. The release tested by diffusion in gelose and high-performance liquid chromatography was found to be 21.4% and 28.2%, respectively, of the amount theoretically present in the beads. Plaster of Paris is a resorbable, nontoxic biomaterial that has already been used to fill dead spaces in bone and deliver antibiotics in the treatment of chronic osteomyelitis. The addition of teicoplanin, a new antistaphylococcal agent with low known bacterial resistance, is a promising alternative. Follow-up tests in vivo, simulating local conditions of the osteomyelitic bone, are necessary to prove efficacy.
Dacquet
V
V
Institut Calot, Berck-sur-Mer, France.
Varlet
A
A
Tandogan
R N
RN
Tahon
M M
MM
Fournier
L
L
Jehl
F
F
Monteil
H
H
Bascoulergue
G
G
D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000032:analysis; D001412:Bacillus subtilis / Q000187:drug effects; D002133:Calcium Sulfate; D002851:Chromatography, High Pressure Liquid; D004337:Drug Carriers; D004353:Drug Evaluation, Preclinical; D006020:Glycopeptides / Q000008:administration & dosage / Q000032:analysis; D008826:Microbial Sensitivity Tests / Q000379:methods; D013211:Staphylococcus aureus / Q000187:drug effects; D013242:Sterilization / Q000379:methods; D017334:Teicoplanin; D013997:Time Factors
D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D006020:Glycopeptides; D017334:Teicoplanin; D002133:Calcium Sulfate