Porphyrinogenic properties of the anesthetic enflurane.
1. The effect of enflurane, a volatile anesthetic, on heme metabolism was studied. Different doses (0.5-6.0 ml/kg) of this anesthetic were administered i.p. to mice and animals sacrificed at different times after administration (5-240 min). 2. The dose of 2 ml/kg was chosen as the optimum anesthetic dose producing more alterations in the heme pathway. 3. ALA-S was significantly induced at earlier times of anesthesia. 4. Blood PBGase and deaminase was greatly reduced. 5. This diminution coupled with ALA-S induction are in accordance with the known biochemical changes occurring in acute intermittent porphyria and include enflurane in the list of porphyrinogenic drugs, the use of which is not recommended for the management of anesthesia in porphyric patients.
Buzaleh
A M
AM
Centro de Investigaciones sobre Porfirinas v Porifirias (CIPYP), (CONICET-FCEN, UBA), Ciudad Universitaria, Buenos Aires, Argentine.
Enriquez de Salamanca
R
R
Batlle
A M
AM
D000624:5-Aminolevulinate Synthetase / Q000378:metabolism; D000642:Ammonia-Lyases / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004737:Enflurane / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D006418:Heme / Q000096:biosynthesis; D007668:Kidney / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D051379:Mice; D011166:Porphyrins / Q000096:biosynthesis*
D001786:Blood Glucose; D011166:Porphyrins; D006418:Heme; D004737:Enflurane; D000624:5-Aminolevulinate Synthetase; D000642:Ammonia-Lyases; C100132:porphobilinogenase; D005947:Glucose