X-linked gene MIC5 codes for the L1 adhesion molecule recognized by monoclonal antibody R1.
Monoclonal antibody (MoAb) R1 was generated by use of human-mouse hybrids containing only the long arm of chromosome X as the human component. It recognizes plasma membrane glycoproteins of 145 and 200 kd as well as a soluble protein of 195 kd. In this study, using a biochemical approach, we identified these glycoproteins as the human L1 adhesion molecule.
Patel
K
K
Imperial Cancer Research Fund, Frenchay Hospital, Bristol, England.
Banting
G
G
Frost
G
G
Kemshead
J T
JT
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D015153:Blotting, Western; D015816:Cell Adhesion Molecules, Neuronal / Q000737:chemistry / Q000235:genetics*; D000939:Epitopes / Q000276:immunology; D006801:Humans; D006825:Hybridomas / Q000276:immunology; D007163:Immunosorbent Techniques; D039841:Leukocyte L1 Antigen Complex; D051379:Mice; D009447:Neuroblastoma; D014407:Tumor Cells, Cultured; D014960:X Chromosome
D000911:Antibodies, Monoclonal; D015816:Cell Adhesion Molecules, Neuronal; D000939:Epitopes; D039841:Leukocyte L1 Antigen Complex