title: Interstitial pneumonia in simian immunodeficiency virus infection.
abstract: Interstitial pneumonia unrelated to Pneumocystis carinii or other infections was observed histopathologically in 5 of 25 rhesus monkeys infected with simian immunodeficiency virus (SIV). The predominant lesion was lymphocytic infiltration of interalveolar septa and hyperplasia of peribronchial and perivascular lymphoid tissue. Immunohistochemical staining using a panel of antibodies against human T and B lymphocytes, macrophages, and immunoglobulins showed that peribronchial aggregates and interstitial infiltrates were predominantly B cells, whereas perivascular masses consisted mainly of T cells. One animal with a primary B-cell lymphoma of the spinal cord had secondary plasmacytoid lymphomatous nodules throughout the lung which were accompanied locally by reactive B-cell lymphoid follicles. Another animal also had large areas of diffuse alveolar fibrosis and epithelial metaplasia to a bronchiolar type. In two monkeys, branches of the pulmonary arteries showed intimal proliferation and organizing occlusive thrombi, some of which were mineralized.
authors.affiliation: Division of Pathology, Centre for Applied Microbiology and Research, Porton Down, Salisbury, Wiltshire, U.K.
authors.forename: A
authors.initials: A
authors.lastname: Baskerville
authors.forename: A D
authors.initials: AD
authors.lastname: Ramsay
authors.forename: B J
authors.initials: BJ
authors.lastname: Addis
authors.forename: M J
authors.initials: MJ
authors.lastname: Dennis
authors.forename: R W
authors.initials: RW
authors.lastname: Cook
authors.forename: M P
authors.initials: MP
authors.lastname: Cranage
authors.forename: P J
authors.initials: PJ
authors.lastname: Greenaway
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000473:pathology; D007143:Immunoglobulin Heavy Chains / Q000032:analysis; D007147:Immunoglobulin Light Chains / Q000032:analysis; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008168:Lung / Q000473:pathology*; D008253:Macaca mulatta; D008264:Macrophages / Q000473:pathology; D011658:Pulmonary Fibrosis / Q000473:pathology*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology
chemical_list: D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D007633:Keratins