The effect of axon injury on microtubule-associated protein MAP2 mRNA in the hypoglossal nucleus of the adult rat.
High molecular weight microtubule-associated protein 2 (HW MAP2) is heavily concentrated in mature dendrites and may be critical for dendritic stability. Motor axon injury results in retraction of the dendritic tree which is associated with a decrease in MAP 2-like immunoreactivity (-LIR). Here we have shown with in situ hybridization that motor axon injury results in reduced expression of HW MAP2 mRNA in affected neurons. We conclude that axotomy induces a down-regulation of HW MAP2 synthesis.
Svensson
M
M
Department of Anatomy, Karolinska Institutet, Stockholm, Sweden.
Aldskogius
H
H
D000818:Animals; D016375:Antisense Elements (Genetics); D001369:Axons / Q000502:physiology*; D001483:Base Sequence; D001933:Brain Stem / Q000502:physiology*; D005260:Female; D007002:Hypoglossal Nerve / Q000502:physiology*; D008869:Microtubule-Associated Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D016375:Antisense Elements (Genetics); D008869:Microtubule-Associated Proteins; D012333:RNA, Messenger