Synthesis and ADA inhibitory activity of new 2-aryl-8-azaadenosines. VIII.
Title compounds were synthesized from the protected beta-D-ribofuranosyl-1-azide, the sodium salt of malononitrile and the suitable aroyl nitrile. The deblocked 8-azaadenosines had shown good activity as inhibitors of adenosine deaminase (ADA) and a non-substrate behaviour toward the hydrolytic deamination promoted by the enzyme.
Biagi
G
G
Istituto di Chimica Farmaceutica e Tossicologica, Università di Pisa, Italy.
Giorgi
I
I
Livi
O
O
Scartoni
V
V
D000241:Adenosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D058892:Adenosine Deaminase Inhibitors; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D009682:Magnetic Resonance Spectroscopy; D013056:Spectrophotometry, Ultraviolet
D058892:Adenosine Deaminase Inhibitors; D000241:Adenosine