title: The influence of intravenous Albunex injections on pulmonary arterial pressure, gas exchange, and left ventricular peak intensity.
abstract: Contrast ultrasonography may be used to assess regional tissue perfusion. The purpose of this study was to evaluate the safety and efficacy of a new, commercially prepared ultrasound contrast agent (Albunex) in dogs. The injections were administered from peripheral intravenous (IV), right atrial (RA), and pulmonary artery (PA) sites. Acute pulmonary hemodynamic and gas exchange effects of low-dose (0.5, 1.0, 2.0 ml) Phase I injections, and high-dose (2.0, 5.0, 10, 20 ml) Phase II injections of Albunex were evaluated in nine dogs. Immediately before and after each injection, pulmonary artery pressure (PAP) and oxygen tension (PO2) were determined. In addition, left ventricular cavity opacification was assessed visually and by videodensitometric off-line analysis. Visual assessment was performed by four blinded observers who graded on a scale of 0 to 3 (0 = no contrast enhancement of the left ventricular (LV) cavity; 1 = weak or suboptimal contrast enhancement; 2 = optimal or excellent contrast enhancement; and 3 = attenuation of the ultrasound signal following a contrast injection). Peak pixel intensity was also determined with videodensitometric analysis. Results showed that significant changes in PAP or PO2 were not noted after Albunex injections, regardless of injection site or dose range. The average change in PAP after Albunex injection was 1.0 mm Hg +/- 1.2 mm Hg (NS), and the average change in PO2 after Albunex injections was 6.2 mm Hg +/- 6.7 mm Hg (NS). The left ventricular cavity peak pixel intensity was dependent on both injection site (PA = RA > IV) and dose range (2.0 = 1.0 > 0.5).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Anesthesia and Critical Care Medicine, University of Chicago, IL 60637.
authors.forename: R
authors.initials: R
authors.lastname: Walker
authors.forename: J G
authors.initials: JG
authors.lastname: Wiencek
authors.forename: S
authors.initials: S
authors.lastname: Aronson
authors.forename: J
authors.initials: J
authors.lastname: Zaroff
authors.forename: D
authors.initials: D
authors.lastname: Glock
authors.forename: R
authors.initials: R
authors.lastname: Thisted
authors.forename: S B
authors.initials: SB
authors.lastname: Feinstein
mesh_terms: D000418:Albumins / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003287:Contrast Media; D004285:Dogs; D004452:Echocardiography / Q000379:methods*; D006325:Heart Atria; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D007267:Injections; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D008863:Microspheres; D010100:Oxygen / Q000097:blood; D010316:Particle Size; D011651:Pulmonary Artery / Q000187:drug effects* / Q000502:physiology; D011659:Pulmonary Gas Exchange / Q000187:drug effects*; D012709:Serum Albumin / Q000008:administration & dosage; D012815:Signal Processing, Computer-Assisted; D016277:Ventricular Function, Left / Q000187:drug effects*
chemical_list: D000418:Albumins; C060687:Albunex; D003287:Contrast Media; D012709:Serum Albumin; D010100:Oxygen