The inhibitory effect of anthranilate derivatives on HCO3-/Cl- exchange in red blood cells of human, pigeon and trout.
All ten of anthranilate derivatives were found to be inhibitors of HCO3-/Cl- exchange in human, trout and pigeon red blood cells. The individual l50 values covered a range of 2-3 orders of magnitude for human, trout and pigeon RBCs. The results obtained confirm that the anion transporting region of the band 3 protein in human, trout and pigeon red blood cells are highly preserved even though the RBCs belong to animals living in entirely different habitats. However, in spite of the general similarities, significant differences between human trout and pigeon red blood cells could be observed. They could be attributed to differences of the hydrophobic character of the various probes.
Romano
L
L
Institute of General Physiology, University of Messina, Italy.
Mandolfino
M
M
Trischitta
F
F
Scuteri
A
A
D000818:Animals; D001457:Anion Exchange Protein 1, Erythrocyte / Q000378:metabolism*; D027321:Anion Transport Proteins; D001639:Bicarbonates / Q000378:metabolism*; D001692:Biological Transport / Q000187:drug effects; D002352:Carrier Proteins / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism*; D010856:Columbidae / Q000097:blood; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D013045:Species Specificity; D013329:Structure-Activity Relationship; D014337:Trout / Q000097:blood; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
D001457:Anion Exchange Protein 1, Erythrocyte; D027321:Anion Transport Proteins; D001639:Bicarbonates; D002352:Carrier Proteins; D002712:Chlorides; D062367:ortho-Aminobenzoates