[Effect of low and high molecular weight dextrans on selected serum lipid parameters. 1].
Three male patients with hyperlipidaemia were given daily infusions of dextran over a period of 10 days. Plasma levels of total cholesterol, LDL and HDL cholesterol, apolipoprotein B and AI and triglycerides were analysed after the infusion of dextrans different in dose and molecular size. Dextrans caused alterations of some plasma lipids and lipoproteins exceeding the haemodilution effect. The degree of lipid lowering depends on the volume and molecular size of the administered dextran.
Rühlmann
C
C
Abteilung Kardiologie/Angiologie, Universität Leipzig.
Koksch
M
M
Kuklinski
B
B
D000328:Adult; D000368:Aged; D001053:Apolipoproteins / Q000097:blood; D001157:Arterial Occlusive Diseases / Q000097:blood / Q000628:therapy*; D002784:Cholesterol / Q000097:blood; D002792:Cholestyramine Resin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003911:Dextrans / Q000008:administration & dosage*; D006438:Hemodilution / Q000379:methods*; D006801:Humans; D007262:Infusions, Intravenous; D007511:Ischemia / Q000097:blood / Q000628:therapy*; D007866:Leg / Q000098:blood supply*; D008055:Lipids / Q000097:blood*; D008148:Lovastatin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight
D001053:Apolipoproteins; D003911:Dextrans; D008055:Lipids; D002792:Cholestyramine Resin; D002784:Cholesterol; D008148:Lovastatin