Lymphatic absorption of 3-phenylamino-1,2-propanediol and its esters.
From oils associated with the toxic syndrome have been isolated 3-phenylamino-1,2-aminophenol (PAP) and diesters with fatty acids in addition to fatty anilides. These substances have been obtained by chemical synthesis and administered orally to rats whose lymphatic canal had previously been cannulated. The lipid fraction of the lymph collected at different time intervals was isolated. Its chromatographic study has confirmed the presence of the mentioned substances, as well as a metabolite of them, demonstrating that these products enter the blood by lymphatic absorption.
Ruiz-Gutiérrez
V
V
Institute of Lipids and their Derivatives, Sevilla, Spain.
Maestro-Durán
R
R
D000042:Absorption; D000814:Aniline Compounds / Q000737:chemistry; D000818:Animals; D001937:Brassica; D002914:Chylomicrons / Q000302:isolation & purification; D004075:Diglycerides / Q000737:chemistry; D004951:Esterification; D004952:Esters; D005227:Fatty Acids / Q000378:metabolism; D005229:Fatty Acids, Monounsaturated; D008055:Lipids / Q000302:isolation & purification; D008208:Lymphatic System / Q000378:metabolism*; D008297:Male; D010938:Plant Oils / Q000032:analysis*; D011409:Propylene Glycols / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D000074262:Rapeseed Oil; D051381:Rats; D017208:Rats, Wistar
D000814:Aniline Compounds; D002914:Chylomicrons; D004075:Diglycerides; D004952:Esters; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D008055:Lipids; D010938:Plant Oils; D011409:Propylene Glycols; D000074262:Rapeseed Oil; C077151:3-phenylamino-1,2-propanediol; C023650:aniline