title: Brainstem glioma after radiation therapy for acute myeloblastic leukemia in a child with Down syndrome. Possible pathogenetic mechanisms.
abstract: A 13-year-old boy with Down syndrome (DS) had a brainstem glioma confirmed at autopsy, 10 years after receiving prophylactic cranial irradiation for acute myeloblastic leukemia. There is no clear association of brain tumors with DS; despite a reported link between leukemia and glioma, a causal association with radiation therapy is more likely.
authors.affiliation: Department of Pathology, New York University Medical Center, NY 10016.
authors.forename: D
authors.initials: D
authors.lastname: Zagzag
authors.forename: D C
authors.initials: DC
authors.lastname: Miller
authors.forename: J
authors.initials: J
authors.lastname: Cangiarella
authors.forename: J C
authors.initials: JC
authors.lastname: Allen
authors.forename: M A
authors.initials: MA
authors.lastname: Greco
mesh_terms: D000293:Adolescent; D001921:Brain / Q000033:anatomy & histology; D001933:Brain Stem / Q000473:pathology*; D016371:Cranial Irradiation / Q000009:adverse effects*; D004314:Down Syndrome / Q000150:complications*; D005910:Glioma / Q000209:etiology*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000209:etiology / Q000532:radiotherapy*; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D016609:Neoplasms, Second Primary / Q000209:etiology