Vinblastine treatment induces dose-dependent increases in the frequency of micronuclei in mouse bone marrow.
The effect of various doses (0.005-2.0 mg/kg b.w.) of vinblastine sulfate (VBL) was studied on the induction of micronuclei in polychromatic and normochromatic erythrocytes (PCE, NCE) of the bone marrow of female BALB/c mice. VBL treatment resulted in a dose-dependent increase in the frequency of micronucleated PCE and NCE, while the PCE/NCE ratio and mitotic index declined with increasing drug dose. The dose-effect curves were linear quadratic for all the parameters studied.
Jagetia
G C
GC
Department of Radiobiology, Kasturba Medical College, Manipal, India.
Jacob
P S
PS
D000704:Analysis of Variance; D000818:Animals; D001854:Bone Marrow Cells; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D015162:Micronucleus Tests; D014747:Vinblastine / Q000633:toxicity*
D014747:Vinblastine