title: Hepatitis C core antibody detection in acute hepatitis and cirrhosis patients from Tunisia.
abstract: The detection of anti-Hepatitis C virus (HCV) Core antibodies is an important addition to HCV antibody testing. In this study it appears to be more specific than the first generation HCV tests and in combination with the detection of anti-C33c antibodies, it is possibly more sensitive. In Tunisia hepatitis C virus is implicated by the presence of anti-Core antibodies in only 8% of the adult cases of acute hepatitis as opposed to 60% for Hepatitis B virus (HBV) and 4% for Hepatitis A virus (HAV). In contrast to the low prevalence of HCV infection among acute hepatitis cases, HCV infection is implicated in 35% of the cirrhosis cases. These results stress the potential importance of HCV infection in the development of cirrhosis which is a relatively common disease in North Africa.
authors.affiliation: Institut de Virologie de Tours, Laboratoire de Microbiologie, Faculté de Pharmacie, France.
authors.forename: P
authors.initials: P
authors.lastname: Coursaget
authors.forename: B
authors.initials: B
authors.lastname: Simpson
authors.forename: N
authors.initials: N
authors.lastname: el Goulli
authors.forename: H
authors.initials: H
authors.lastname: Ben Khelifa
authors.forename: R
authors.initials: R
authors.lastname: Kastally
mesh_terms: D004797:Enzyme-Linked Immunosorbent Assay; D016174:Hepacivirus / Q000276:immunology*; D006508:Hepatitis Antibodies / Q000032:analysis*; D006526:Hepatitis C / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D018937:Hepatitis C Antibodies; D006801:Humans; D008103:Liver Cirrhosis / Q000209:etiology / Q000276:immunology*; D014416:Tunisia; D014758:Viral Core Proteins / Q000276:immunology*
chemical_list: D006508:Hepatitis Antibodies; D018937:Hepatitis C Antibodies; D014758:Viral Core Proteins