title: Oxygen consumption is maintained in fetal sheep during prolonged hypoxaemia.
abstract: Experiments were conducted in 12 chronically-catheterized pregnant sheep to examine the effect of prolonged hypoxaemia secondary to the restriction of uterine blood flow on fetal oxygen consumption. Surgery was performed at 115 days gestation to place a teflon vascular occluder around the maternal common internal iliac artery and for insertion of vascular catheters. Following a 5-day recovery period, uterine blood flow was reduced in 6 animals for 24 hours and in 6 animals, the occluder was not adjusted. Fetal arterial PO2 decreased from 19.9 +/- 2.0 mmHg to 12.8 +/- 2.0 mmHg and 11.0 +/- 2.0 mmHg at 1 and 24 hours respectively in the experimental group and did not change the control group. Fetal pH decreased from 7.34 +/- 0.01 to 7.25 +/- 0.03 and 7.29 +/- 0.02 at 1 and 24 hours of hypoxaemia respectively. Fetal arterial lactate concentrations remained elevated throughout the experimental period with maximum concentrations of 6.6 +/- 2.1 mmol/l being present at 4 hours compared to 1.3 +/- 0.2 mmol/l during the control period. Umbilical blood flow increased from 186 +/- 19 ml/min/kg to 251 +/- 39 ml/min/kg at 1 h of hypoxaemia and returned to 191 +/- 21 ml/min/kg at 24 h. In association with the progressive fall in oxygen delivery to the fetus, oxygen extraction increased from 0.33 +/- 0.04 to 0.43 +/- 0.04 and 0.54 +/- 0.05 at 1 and 24 hours, respectively. Overall oxygen consumption by the fetus remained unchanged from control values.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Obstetrics and Gynaecology, University of Western Ontario, Lawson Research Institute, St. Joseph's Health Centre, London, Canada.
authors.forename: A D
authors.initials: AD
authors.lastname: Bocking
authors.forename: S E
authors.initials: SE
authors.lastname: White
authors.forename: J
authors.initials: J
authors.lastname: Homan
authors.forename: B S
authors.initials: BS
authors.lastname: Richardson
mesh_terms: D000818:Animals; D001794:Blood Pressure; D005260:Female; D005315:Fetal Diseases / Q000378:metabolism* / Q000503:physiopathology; D005333:Fetus / Q000502:physiology; D005740:Gases / Q000097:blood; D006454:Hemoglobins / Q000032:analysis; D006863:Hydrogen-Ion Concentration; D000860:Hypoxia / Q000378:metabolism* / Q000503:physiopathology; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D011247:Pregnancy; D012039:Regional Blood Flow; D012756:Sheep / Q000196:embryology; D013997:Time Factors; D014599:Uterus / Q000098:blood supply; D014680:Veins
chemical_list: D005740:Gases; D006454:Hemoglobins; D010100:Oxygen