Anti-human immunodeficiency virus effects of cationic metalloporphyrin-ellipticine complexes.
A series of cationic metalloporphyrin-ellipticine complexes were found to inhibit the cytopathicity of human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus in MT-4 cells at concentrations ranging from 1.4 to 17 micrograms/mL, i.e. at a concentration that was 2.5-30-fold below the cytotoxicity threshold. These compounds were also found to inhibit syncytium formation between persistently HIV-1-infected HUT-78 and uninfected Molt/4 cells, to interfere with HIV-1 binding to the cells, and to suppress HIV-1-associated reverse transcriptase activity.
Ding
L
L
Laboratoire de Chimie de Coordination du CNRS, Toulouse, France.
Balzarini
J
J
Schols
D
D
Meunier
B
B
de Clercq
E
E
D015704:CD4 Antigens / Q000032:analysis; D002478:Cells, Cultured / Q000187:drug effects; D004611:Ellipticines / Q000494:pharmacology*; D004789:Enzyme Activation; D054303:HIV Reverse Transcriptase; D015497:HIV-1 / Q000187:drug effects* / Q000201:enzymology; D008345:Manganese; D008665:Metalloporphyrins / Q000494:pharmacology*; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism*; D015302:Simian Immunodeficiency Virus / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects; D015032:Zinc
D015704:CD4 Antigens; D004611:Ellipticines; D008665:Metalloporphyrins; D008345:Manganese; D054303:HIV Reverse Transcriptase; D012194:RNA-Directed DNA Polymerase; D015032:Zinc