title: Prenatal cytogenetic diagnosis of 1,400 consecutive amniocenteses.
abstract: We report on the incidence of chromosomal abnormalities in 1,400 amniocenteses. Thirty-one cases (2.21%) were found to have various types of chromosomal abnormality. The majority of abnormal cases (54.84%) were trisomies. All individuals with trisomic fetuses chose to terminate the pregnancy with the exception of one who gave birth to a Down's syndrome child. However, fetuses with apparently balanced translocations were phenotypically normal at birth.
authors.affiliation: Division of Genetics, Long Island College Hospital, SUNY Health Science Center, Brooklyn 11201.
authors.forename: T
authors.initials: T
authors.lastname: Mathews
authors.forename: D
authors.initials: D
authors.lastname: Navsaria
authors.forename: R S
authors.initials: RS
authors.lastname: Verma
mesh_terms: D000649:Amniocentesis; D001723:Birth Rate; D002869:Chromosome Aberrations / Q000453:epidemiology* / Q000235:genetics; D025063:Chromosome Disorders; D006785:Hospitals, University; D006801:Humans; D015994:Incidence; D007621:Karyotyping; D009519:New York City / Q000453:epidemiology; D011296:Prenatal Diagnosis