[Hyperthermia for cancer with dextran magnetite using tubular implants].
Dextran magnetite particles (Meito Sangyo Corp.) are an aqueous magnetite zol and a nanometer complex consisting of dextran chains surrounding a core of ultrafine iron oxide. The tubular implants were made with polyester tube (3 mm diameter, 20 mm length) filled with DM aqueous zol (29%w/v). The temperature of an agar phantom with implants was measured in the inductive field. Heating was effected by creating an electromagnetic field with a 7 kW generator operating at 500kHz (Yamamoto Vinyter). The temperature was elevated 3.4 degrees at a distance of 5 mm from the implant at an inductive power of 2.6 kW. An area of 20 x 20 mm was heated while changing the power, the number of implants, and their arrangement. Selective heating of cancer was considered possible by inductive heating at 500 kHz and DM implants. Since the DM aqueous zol configuration can be readily changed, treatment of various cancers is possible.
Takemori
S
S
Second Dept. of Surgery, Faculty of Medicine, Toyama Medical and Pharmaceutical University.
Tazawa
K
K
Nagae
H
H
Shimizu
T
T
Masuko
Y
Y
Okamoto
M
M
Fujimaki
M
M
D003911:Dextrans / Q000008:administration & dosage*; D004343:Drug Implants; D004574:Electromagnetic Fields; D006979:Hyperthermia, Induced / Q000379:methods; D007501:Iron; D008961:Models, Structural; D009369:Neoplasms / Q000628:therapy; D010087:Oxides
D003911:Dextrans; D004343:Drug Implants; D010087:Oxides; D007501:Iron