The Lennox-Gastaut syndrome: electroencephalographic characteristics, clinical correlates, and follow-up studies.
Electroencephalographic and clinical findings are reported for 100 patients with the Lennox-Gastaut (LGS) triad of slow bilateral spike and wave (BSW), retardation and multiple seizures. Neurological and mental deficits were frequently observed, especially in patients who developed seizures before age 1 yr. More than half of the patients had focal epileptiform discharges that peaked in occurrence at age 4-6 yrs. EEG follow-up showed that background frequency slowed when patients developed the LGS pattern, and increased after recovery. Only 2 patients developed normal EEGs on follow-up, although 22 patients no longer showed the LGS pattern after an average of 3 yrs 3 mos follow-up.
Fitzgerald
L F
LF
University of Illinois Medical Center, Department of Neurology and Neurosurgery, Chicago 60612.
Stone
J L
JL
Hughes
J R
JR
Melyn
M A
MA
Lansky
L L
LL
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D004827:Epilepsy / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D012890:Sleep / Q000502:physiology; D013577:Syndrome