Parathyroid hormone activation of stretch-activated cation channels in osteosarcoma cells (UMR-106.01).
Cell-attached patches of membrane of osteoblast-like cells UMR-106.01 respond to bath application of parathyroid hormone (PTH) with an increase in the average activity, as well as the single channel conductance, of a stretch-activated non-selective cation channel. Correlations with whole cell membrane potential and conductance changes are considered.
Duncan
R L
RL
Department of Medicine, Jewish Hospital, Washington University Medical Center, St. Louis, MO 63110.
Hruska
K A
KA
Misler
S
S
D000818:Animals; D004553:Electric Conductivity; D015640:Ion Channel Gating / Q000502:physiology*; D007473:Ion Channels / Q000502:physiology*; D008465:Mechanoreceptors / Q000502:physiology; D012516:Osteosarcoma; D010281:Parathyroid Hormone / Q000502:physiology*; D051381:Rats; D014407:Tumor Cells, Cultured
D007473:Ion Channels; D010281:Parathyroid Hormone