Characterization of the human IgG antibody VL repertoire to Haemophilus influenzae type b polysaccharide.
The human antibody response to the capsular polysaccharide of Haemophilus influenzae type b (Hib) is a good model for examining human V region repertoires. While the VL repertoire of human antibodies to Hib polysaccharide is relatively simple and dominated by the product of a germline V kappa II gene named A2, at least five other VL genes can be expressed by some individuals. These include at least two V kappa I products and at least one V kappa III, one V kappa IV, and one V lambda product. The epitope recognized by a monoclonal anti-idiotype antibody is on the A2 V kappa II product.
Scott
M G
MG
Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.
Nahm
M H
MH
D000328:Adult; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D016667:Bacterial Capsules; D001428:Bacterial Vaccines / Q000276:immunology*; D004168:Diphtheria Toxoid / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D015964:Gene Expression Regulation, Bacterial; D005803:Genes, Immunoglobulin; D018073:Haemophilus Vaccines; D006193:Haemophilus influenzae / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis* / Q000235:genetics; D007147:Immunoglobulin Light Chains / Q000235:genetics*; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D007145:Immunoglobulin kappa-Chains / Q000235:genetics; D011135:Polysaccharides, Bacterial / Q000276:immunology*
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D004168:Diphtheria Toxoid; D000939:Epitopes; D018073:Haemophilus Vaccines; C044237:Haemophilus influenzae type b polysaccharide vaccine; C052180:Haemophilus influenzae type b-polysaccharide vaccine-diphtheria toxoid conjugate; D007074:Immunoglobulin G; D007147:Immunoglobulin Light Chains; D007135:Immunoglobulin Variable Region; D007145:Immunoglobulin kappa-Chains; D011135:Polysaccharides, Bacterial