title: Differential effects of ibogaine pretreatment on brain levels of morphine and (+)-amphetamine.
abstract: Previous studies in rats have shown that ibogaine inhibits neurochemical and behavioral effects of morphine yet potentiates similar effects of (+)-amphetamine. To assess whether these different functional interactions have a metabolic basis, brain levels of morphine and (+)-amphetamine were measured by gas chromatography-mass spectrometry after ibogaine pretreatment (19 h before injection of morphine or (+)-amphetamine). Ibogaine pretreatment had no effect on brain morphine levels, either at 30 min or 2 h after morphine injection; however, ibogaine significantly increased brain amphetamine levels at 30 min and, to a greater extent, at 2 h after (+)-amphetamine injection. These and other data suggest that ibogaine irreversibly inhibits an amphetamine-metabolizing enzyme. The functional interactions between ibogaine and (+)-amphetamine, but not those between ibogaine and morphine, may result from a hepatic drug-drug interaction.
authors.affiliation: Department of Pharmacology and Toxicology, Albany Medical College, NY 122208.
authors.forename: S D
authors.initials: SD
authors.lastname: Glick
authors.forename: C A
authors.initials: CA
authors.lastname: Gallagher
authors.forename: L B
authors.initials: LB
authors.lastname: Hough
authors.forename: K L
authors.initials: KL
authors.lastname: Rossman
authors.forename: I M
authors.initials: IM
authors.lastname: Maisonneuve
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003913:Dextroamphetamine / Q000493:pharmacokinetics*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006207:Half-Life; D007050:Ibogaine / Q000494:pharmacology*; D009020:Morphine / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D007050:Ibogaine; D009020:Morphine; D003913:Dextroamphetamine