title: TLC G-65 in combination with other agents in the therapy of Mycobacterium avium infection in beige mice.
abstract: The activity of TLC G-65 (a liposomal gentamicin preparation), alone and in combination with rifapentine, clarithromycin, clofazimine and ethambutol, was evaluated in the beige mouse (C57BL/6J--bgj/bgj) model of disseminated Mycobacterium avium infection. TLC G-65 was found to be more active than amikacin. The combination of rifapentine and TLC G-65 was more active than either agent alone. The activity of clarithromycin in combination with TLC G-65 was similar to that of either agent alone. Clofazimine improved the activity of TLC G-65 with respect to the spleen, while ethambutol improved the activity with respect to the liver. Clofazimine and ethambutol enhanced the activity of TLC G-65 against bacteria in the lungs. TLC G-65 in combination with rifapentine appears to be an attractive regimen for the treatment of infections caused by bacteria in the M. avium complex.
authors.affiliation: Veterans Affairs Medical Center, Syracuse, New York.
authors.forename: M H
authors.initials: MH
authors.lastname: Cynamon
authors.forename: S P
authors.initials: SP
authors.lastname: Klemens
authors.forename: C E
authors.initials: CE
authors.lastname: Swenson
mesh_terms: D000583:Amikacin / Q000627:therapeutic use; D000818:Animals; D000995:Antitubercular Agents / Q000627:therapeutic use; D017291:Clarithromycin; D002991:Clofazimine / Q000627:therapeutic use; D003470:Culture Media; D004359:Drug Therapy, Combination; D004917:Erythromycin / Q000031:analogs & derivatives / Q000627:therapeutic use; D004977:Ethambutol / Q000627:therapeutic use; D005839:Gentamicins / Q000627:therapeutic use*; D008081:Liposomes; D051379:Mice; D008810:Mice, Inbred C57BL; D009162:Mycobacterium avium; D012293:Rifampin / Q000031:analogs & derivatives / Q000627:therapeutic use; D014376:Tuberculosis / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D003470:Culture Media; D005839:Gentamicins; D008081:Liposomes; D004917:Erythromycin; D000583:Amikacin; D004977:Ethambutol; D002991:Clofazimine; D017291:Clarithromycin; D012293:Rifampin; C018421:rifapentine