Spotlight article: thrombolysis in unstable angina: randomized double-blind trial of t-PA and placebo. Circulation 1992;85: 150-7. (Freeman MR, Langer A, Wilson RF, Morgan CD, Armstrong PW.).
This is a well-written and executed study that indicates that infusion of t-PA in patients with unstable angina does not decrease in-hospital cardiac events and, in fact, may worsen myocardial perfusion. The small sample size requires further study replication.
Kennedy
G T
GT
University of Texas Health Science Center, San Antonio.
D000789:Angina, Unstable / Q000150:complications / Q000188:drug therapy*; D004311:Double-Blind Method; D017052:Hospital Mortality; D006801:Humans; D015994:Incidence; D009203:Myocardial Infarction / Q000453:epidemiology / Q000209:etiology; D016032:Randomized Controlled Trials as Topic / Q000379:methods / Q000592:standards*; D012107:Research Design / Q000592:standards; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome
D010959:Tissue Plasminogen Activator