title: MIDAS: hypertension and atherosclerosis. A trial of the effects of antihypertensive drug treatment on atherosclerosis. MIDAS Research Group.
abstract: Although clinical trials of the efficacy of antihypertensive treatment have demonstrated impressive reductions in the incidence of stroke, the reduction in coronary artery disease mortality has been less impressive. It may be that the antihypertensive drugs used in these trials induced metabolic disturbances, or produced inadequate regression of left ventricular hypertrophy, thus blunting the reduction in risk of coronary artery disease expected with blood pressure-lowering. Isradipine, a dihydropyridine calcium antagonist known to be an effective antihypertensive agent, has also displayed pronounced antiatherogenic effects in animals. Thus, a reasonable hypothesis could be that isradipine not only reduces the level of blood pressure, but also may have a positive effect on the evolution of atherosclerotic plaque in coronary and carotid arteries, thereby leading to prevention of clinical sequelae of atherosclerosis. On this basis, a 3-year clinical trial is being carried out in the United States--the Multicenter Isradipine/Diuretic Atherosclerosis Study (MIDAS)--to establish the efficacy of isradipine in inhibiting atherogenesis and retarding the progression of atherosclerosis in carotid arteries of hypertensive patients. The primary end point of the study is intima-media thickness and the extent of atherosclerotic plaque in the carotid arteries, as measured by B-mode ultrasonography.
authors.affiliation: University of California, Davis.
authors.forename: N O
authors.initials: NO
authors.lastname: Borhani
authors.forename: S T
authors.initials: ST
authors.lastname: Miller
authors.forename: S B
authors.initials: SB
authors.lastname: Brugger
authors.forename: H W
authors.initials: HW
authors.lastname: Schnaper
authors.forename: T E
authors.initials: TE
authors.lastname: Craven
authors.forename: M G
authors.initials: MG
authors.lastname: Bond
authors.forename: S
authors.initials: S
authors.lastname: Khoury
authors.forename: J
authors.initials: J
authors.lastname: Flack
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000188:drug therapy*; D004095:Dihydropyridines / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D017275:Isradipine; D008297:Male
chemical_list: D000959:Antihypertensive Agents; D004095:Dihydropyridines; D006852:Hydrochlorothiazide; D017275:Isradipine