Antimutagenic effect of eight natural foods on moldy foods in a high liver cancer incidence area.
Ames test procedures were used to test 8 natural food extracts for their antimutagenic activity against the mutagenic activity induced in S. typhimurium strains TA98 and TA100 by aflatoxin B1 (AFB1) or metabolic extracts from A. versicolor or A. ochraceus. The tested substances were extracted repeatedly with acetone. The revertants induced by AFB1, metabolic extracts of A. versicolor or A. ochraceus were significantly decreased when extracts of the 8 natural foods were added to the media. The results showed that these extracts had marked inhibitory effects on the mutagenic activity induced by AFB1 or metabolic extracts of the two molds and also suggested that antimutagenic substances were present in these natural foods. These experiments provide a scientific basis for the study of food substances for the prevention of carcinogenesis. It is considered that these 8 natural food extracts produce marked antimutagenic effects and are practically valuable in the field of chemoprophylaxis of liver cancer in humans.
Ruan
C C
CC
Guangxi Cancer Institute, Nanning, China.
Liang
Y
Y
Liu
J L
JL
Tu
W S
WS
Liu
Z H
ZH
D016604:Aflatoxin B1 / Q000037:antagonists & inhibitors / Q000633:toxicity; D016587:Antimutagenic Agents; D002681:China / Q000453:epidemiology; D005502:Food; D008113:Liver Neoplasms / Q000453:epidemiology / Q000517:prevention & control; D009152:Mutagenicity Tests; D009183:Mycotoxins / Q000037:antagonists & inhibitors / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
D016587:Antimutagenic Agents; D009183:Mycotoxins; D016604:Aflatoxin B1