Assignment of the human cyclin D3 gene (CCND3) to chromosome 6p----q13.
The PRAD1/cyclin D1 gene (CCND1), a member of the D-type cyclin gene family, has been implicated as a protooncogene in parathyroid, lymphoid, and mammary tumors. We cloned and mapped another member of this family, the human cyclin D3 gene (CCND3), to chromosome 6p----q13 using human x rodent hybrids. This assignment raises the hypothesis that cyclin D3 may be involved in the pathogenesis of human neoplasms with abnormalities of chromosome 6.
Motokura
T
T
Endocrine Unit, Massachusetts General Hospital, Boston 02114.
Yi
H F
HF
Kronenberg
H M
HM
McBride
O W
OW
Arnold
A
A
D015139:Blotting, Southern; D002896:Chromosomes, Human, Pair 6; D003001:Cloning, Molecular; D016213:Cyclins / Q000235:genetics*; D015723:Gene Library; D006801:Humans; D006822:Hybrid Cells; D005810:Multigene Family / Q000235:genetics; D011519:Proto-Oncogenes / Q000235:genetics
D016213:Cyclins