Parental imprinting of the human H19 gene.
It has only recently become clear that genetic imprinting plays an important role in human embryogenesis and in processes leading to the development of pediatric cancers and other human diseases. Using a unique human tissue, the androgenetic complete hydatidiform mole, we established that the maternally inherited allele of the imprinted H19 gene is expressed. Our results also show that the paternal allele of the human IGF-II gene, a gene suspected to be parentally imprinted in humans, is expressed.
Rachmilewitz
J
J
Department of Biological Chemistry, Silberman Institute of Life Sciences, Hebrew University, Jerusalem, Israel.
Goshen
R
R
Ariel
I
I
Schneider
T
T
de Groot
N
N
Hochberg
A
A
D015152:Blotting, Northern; D002460:Cell Line; D002822:Choriocarcinoma / Q000235:genetics*; D004622:Embryo, Mammalian; D005260:Female; D015870:Gene Expression; D005796:Genes; D006801:Humans; D006828:Hydatidiform Mole / Q000235:genetics*; D007335:Insulin-Like Growth Factor II / Q000235:genetics; D010920:Placenta / Q000502:physiology*; D011247:Pregnancy; D012313:RNA / Q000235:genetics / Q000302:isolation & purification; D012334:RNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D014594:Uterine Neoplasms / Q000235:genetics*
D012334:RNA, Neoplasm; D012313:RNA; D007335:Insulin-Like Growth Factor II