title: Activation of the glutamate metabotropic receptor protects retina against N-methyl-D-aspartate toxicity.
abstract: Intraocular pretreatment with the specific metabotropic glutamate receptor agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) in the adult rat reduced the excitotoxic effects induced in the retina by a single intraocular injection of N-methyl-D-aspartate (NMDA). Damage was estimated by assessing NMDA-induced loss of retinal choline acetyltransferase (ChAT) activity. The interaction between metabotropic and ionotropic glutamate receptors may, therefore, be considered an important target for in vivo pharmacological neuroprotection.
authors.affiliation: Fidia Research Laboratories, Abano Terme, PD, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Siliprandi
authors.forename: M
authors.initials: M
authors.lastname: Lipartiti
authors.forename: E
authors.initials: E
authors.lastname: Fadda
authors.forename: J
authors.initials: J
authors.lastname: Sautter
authors.forename: H
authors.initials: H
authors.lastname: Manev
mesh_terms: D000818:Animals; D003515:Cycloleucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D016202:N-Methylaspartate / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D017470:Receptors, Glutamate / Q000187:drug effects*; D012160:Retina / Q000187:drug effects*
chemical_list: D017470:Receptors, Glutamate; D003515:Cycloleucine; C036361:1-amino-1,3-dicarboxycyclopentane; D016202:N-Methylaspartate