Enhanced photorelaxation in aorta, pulmonary artery and corpus cavernosum produced by BAY K 8644 or N-nitro-L-arginine.
Segments of endothelium-denuded aorta, pulmonary arterial rings and strips of corpus cavernosum from rabbits were superfused with Krebs medium. Photorelaxation elicited by ultraviolet light (366 nm) was significantly enhanced by either BAY K 8644 (20 nM) or N-nitro-L-arginine (100 and 500 microM) and was associated with increased cyclic GMP. This action of both drugs was greater in pulmonary artery than aorta and corpus cavernosum and persisted in vascular rings for 90 min after drug removal. The effect was significantly attenuated by hemoglobin (10 microM) but was unaltered by superoxide dismutase (30 u/ml). The mechanism of such photosensitization is presently unclear.
Chen
X
X
Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06510.
Gillis
C N
CN
D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects*; D001120:Arginine / Q000031:analogs & derivatives* / Q000494:pharmacology; D002426:Cavernous Sinus / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects*; D006152:Cyclic GMP / Q000378:metabolism; D004307:Dose-Response Relationship, Radiation; D066298:In Vitro Techniques; D008027:Light; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects*; D019335:Nitroarginine; D011651:Pulmonary Artery / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects*; D011817:Rabbits; D014466:Ultraviolet Rays; D014664:Vasodilation / Q000187:drug effects / Q000528:radiation effects*
D019335:Nitroarginine; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D001120:Arginine; D006152:Cyclic GMP