Bactericidal action of a glycoprotein from the body surface mucus of giant African snail.
1. Bactericidal action of a glycoprotein, Achacin, purified from the giant African snail, Achatina fulica Férussac, has been studied. 2. Achacin kills both gram-positive and gram-negative bacteria, but only in their growing states. 3. Achacin does not have any bacteriolytic activity. 4. The strain which has no cell wall is a little more sensitive than the native strain and the cell membrane-damaged strain. 5. Achacin was observed on the cytoplasmic membrane and on the cell wall of treated Escherichia coli by immunoelectron microscopy. 6. Achacin attacks the cytoplasmic membrane of the cell.
Otsuka-Fuchino
H
H
Department of Chemistry, Faculty of Science and Technology, Sophia University, Tokyo, Japan.
Watanabe
Y
Y
Hirakawa
C
C
Tamiya
T
T
Matsumoto
J J
JJ
Tsuchiya
T
T
D000818:Animals; D002122:Calcium Chloride / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D003091:Colistin / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects*; D006023:Glycoproteins / Q000494:pharmacology*; D006096:Gramicidin / Q000494:pharmacology; D016253:Microscopy, Immunoelectron; D009093:Mucus / Q000737:chemistry*; D009711:Nucleotides / Q000378:metabolism; D012908:Snails / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects*
D006023:Glycoproteins; D009711:Nucleotides; D006096:Gramicidin; D003609:Dactinomycin; D004492:Edetic Acid; D002122:Calcium Chloride; D003091:Colistin