Do analogues of gonadotrophin releasing hormone influence follicular fluid steroid levels, oocyte maturity and fertilization rates?
One-hundred-and-twelve samples of follicular fluid from 32 patients undergoing in-vitro fertilization and embryo transfer were analysed in this study. The follicular fluids were analysed for any relationships between oestradiol, progesterone and 17 alpha-hydroxyprogesterone levels, the progesterone/oestradiol and 17 alpha-hydroxyprogesterone/oestradiol ratios and oocyte maturity and fertilization rates. In Group A, consisting of women who used analogues of gonadotrophin-releasing hormone during ovarian stimulation with human menopausal gonadotrophin, the progesterone/oestradiol ratio rose in parallel with the fertilization rate (P less than 0.05). Group B comprised patients treated with human menopausal gonadotrophin alone. No significant relationship was found between the other parameters, oocyte maturation and fertilization rates in either group.
Tavmergen
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Department of Obstetrics and Gynaecology, Ege University Faculty of Medicine Bornova, Izmir, Turkey.
Tavmergen
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Capanoğlu
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D019326:17-alpha-Hydroxyprogesterone; D000328:Adult; D000704:Analysis of Variance; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D004958:Estradiol / Q000096:biosynthesis; D005260:Female; D005306:Fertilization / Q000187:drug effects*; D005307:Fertilization in Vitro; D015571:Follicular Fluid / Q000737:chemistry* / Q000187:drug effects*; D012739:Gonadal Steroid Hormones / Q000096:biosynthesis*; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D006908:Hydroxyprogesterones / Q000097:blood; D008186:Luteolytic Agents / Q000494:pharmacology*; D008596:Menotropins / Q000627:therapeutic use; D009865:Oocytes / Q000187:drug effects* / Q000502:physiology; D010062:Ovulation Induction; D011374:Progesterone / Q000096:biosynthesis; D017329:Triptorelin Pamoate
D006063:Chorionic Gonadotropin; D012739:Gonadal Steroid Hormones; D006908:Hydroxyprogesterones; D008186:Luteolytic Agents; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D004958:Estradiol; D008596:Menotropins; D019326:17-alpha-Hydroxyprogesterone