Determination of the absolute configuration of the active amlodipine enantiomer as (-)-S: a correction.
The active (-) enantiomer of amlodipine was originally reported to have R configuration. This does not concur with other 1,4-dihydropyridines with known absolute configuration. This configuration has now been determined by X-ray structural analysis using (1S)-camphanic acid and (S)-2-methoxy-2-phenylethanol as chiral probes. Both determinations gave the S configuration for the amlodipine (-) enantiomer with the greater Ca-antagonistic activity.
Goldmann
S
S
Bayer AG, Pharma Research Center, Wuppertal, Germany.
Stoltefuss
J
J
Born
L
L
D017311:Amlodipine; D008968:Molecular Conformation; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000737:chemistry; D013237:Stereoisomerism; D014961:X-Ray Diffraction
D017311:Amlodipine; D009543:Nifedipine