Quantitative structure-mutagenic activity relationships of triazino indole derivatives.
The mutagenicity of 3-(4'-benzylidenamino)-5H-1,2,3-triazin[5,4-b]-indol-4-one derivatives, new compounds with considerable platelet antiaggregating activity, was assayed with the Ames test using the Salmonella typhimurium strains TA97, TA98, TA100 and TA102. The adaptive least-squares method (ALS method) was used to carry out a quantitative structure-activity relationship (QSAR) analysis. Three equations, based on 10 congeners, were found for strains TA97, TA98 and TA100. The results suggest that lipophilicity of the substituent decreases the mutagenicity of the series.
García
E
E
C.I.F.A., Universidad de Navarra, Pamplona, Spain.
Lopez-de-Cerain
A
A
Martinez-Merino
V
V
Monge
A
A
D015197:Carcinogenicity Tests; D007211:Indoles / Q000737:chemistry / Q000633:toxicity*; D016018:Least-Squares Analysis; D016296:Mutagenesis; D009152:Mutagenicity Tests; D009153:Mutagens / Q000737:chemistry / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D013329:Structure-Activity Relationship
D007211:Indoles; D009153:Mutagens