title: Renal function in preterm infants during the first five days of life: influence of maturation and early colloid treatment.
abstract: We measured the influence of maturation and early freshly frozen plasma infusion (FFP) on renal function (day 2 and day 5) in preterm infants in intensive care; they were divided into two groups, those with gestational ages less than 30 weeks (G less than 30) and those with gestational ages of 30-34 weeks (G 30-34). A total of 35 infants was studied. The infants were randomly assigned to one of two treatment groups, one receiving FFP, the other not, yielding four study groups; G less than 30 and no FFP (8 infants), G less than 30 and FFP (8 infants), G 30-34 and no FFP (9 infants) and G 30-34 and FFP (10 infants). The infants in the two FFP groups received FFP 10 ml/kg on days 1-3. FFP did not significantly influence creatinine clearance (CCr) or the urinary sodium excretion rate either in G less than 30 or G 30-34. CCr was significantly lower (p less than 0.001) and fractional urinary sodium excretion significantly higher (p less than 0.002) in infants of G less than 30 than in infants of G 30-34. Infants of G less than 30 had significantly higher plasma potassium concentrations (p less than 0.01) than infants of G 30-34. Despite the low CCr and the high urinary sodium excretion rate, infants of G less than 30 had stable fluid and electrolyte balance.
authors.affiliation: Department of Pediatrics, University of Turku, Finland.
authors.forename: H
authors.initials: H
authors.lastname: Ekblad
authors.forename: P
authors.initials: P
authors.lastname: Kero
authors.forename: H
authors.initials: H
authors.lastname: Korvenranta
mesh_terms: D000375:Aging / Q000502:physiology*; D003102:Colloids / Q000627:therapeutic use*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D007668:Kidney / Q000378:metabolism / Q000502:physiology*; D010949:Plasma / Q000502:physiology; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000652:urine; D014882:Water-Electrolyte Balance / Q000502:physiology
chemical_list: D003102:Colloids; D012964:Sodium; D011188:Potassium