[Effect of 764-3 on bleomycin activation of alveolar macrophages].
The effect of pretreatment with 764-3, a huo xue hua yu medicine, on bleomycin A6 activation of alveolar macrophages of rats was observed. Results showed that bleomycin A6 could activate alveolar macrophages directly and that 764-3 could inhibit the activating effect of bleomycin A6. When alveolar macrophages are activated, they release not only PMN chemotactic factor, but also many destructive lysosomal enzymes, superoxide anions, etc, possibly resulting in serious injury to the lungs.
Yu
L
L
Institute of Basic Medical Sciences, Beijing.
D000818:Animals; D001761:Bleomycin / Q000494:pharmacology* / Q000031:analogs & derivatives; D002630:Chemotactic Factors / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008262:Macrophage Activation / Q000187:drug effects*; D016676:Macrophages, Alveolar / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D002630:Chemotactic Factors; D004365:Drugs, Chinese Herbal; C052656:bleomycin A6; D001761:Bleomycin