Expression of activins and TGF beta 1 and beta 2 RNAs in early postimplantation mouse embryos and uterine decidua.
The expression of the mesoderm inducing factors, activins and TGF beta s, was characterized in 5 1/2-9 1/2 day mouse embryos and implantation sites by in situ hybridization. Activin beta A RNA was not detected within the embryo, but is expressed in nearby decidual cells from 5 to 7 days. Thus activin A could play a role within the embyro during gastrulation. Activin beta A is also expressed in more mesometrially located decidual cells from 6 to 9 1/2 days. Activin beta B and inhibin alpha RNAs were not detected, while a control tissue was highly positive. TGF beta 1 is expressed in the secondary decidual zone and in developing endothelial cells in the decidua and embryo. TGF beta 2 is expressed in the mesometrial decidua at 6 1/2 days and in the midline of the cranial neural plate.
Manova
K
K
Department of Cell Biology and Anatomy, Cornell University Medical College, New York, NY 10021.
Paynton
B V
BV
Bachvarova
R F
RF
D028341:Activins; D000818:Animals; D003656:Decidua / Q000737:chemistry / Q000378:metabolism*; D004475:Ectoderm / Q000737:chemistry / Q000378:metabolism; D004627:Embryonic Induction / Q000235:genetics*; D004730:Endothelium, Vascular / Q000737:chemistry / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation; D005865:Gestational Age; D007265:Inhibins / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D009693:Nucleic Acid Hybridization; D012313:RNA / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000235:genetics* / Q000378:metabolism
D016212:Transforming Growth Factor beta; D028341:Activins; D007265:Inhibins; D012313:RNA