Loss of chromosome 3 alleles and multiplication of chromosome 8 alleles in uveal melanoma.
Uveal melanoma is the most frequent primary intraocular tumor. The etiology is unknown. Using neutral DNA polymorphisms on chromosomes 2, 3, and 8, we have detected loss of chromosome 3 alleles in 8 of 13 tumors and multiplication of chromosome 8 alleles in 6 of 11 tumors. No anomalies at a locus on chromosome 2 were found in 10 of 10 tumors. These results confirm and extend previous cytogenetic findings and suggest that a tumor suppressor gene on chromosome 3 and an oncogene on chromosome 8 may be involved in the formation or progression of this tumor.
Horsthemke
B
B
Institut für Humangenetik, Universitätsklinikum Essen, Federal Republic of Germany.
Prescher
G
G
Bornfeld
N
N
Becher
R
R
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D014408:Biomarkers, Tumor; D015139:Blotting, Southern; D002872:Chromosome Deletion; D002893:Chromosomes, Human, Pair 3; D002898:Chromosomes, Human, Pair 8; D004247:DNA / Q000032:analysis; D003720:Densitometry; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008545:Melanoma / Q000235:genetics*; D008875:Middle Aged; D005810:Multigene Family; D011110:Polymorphism, Genetic; D014604:Uveal Neoplasms / Q000235:genetics*
D014408:Biomarkers, Tumor; D004247:DNA