[Blockage of glyrrhiza uralensis and chelidonium majus in MNNG induced cancer and mutagenesis].
Glyrrhiza Uralensis (GU) and Chelidonium Majus (CM) are two kinds of Chinese herbal medicine. GU and CM not only exert much stronger effects in blocking mutagenesis due to strains of Salmonella typhimurium (TA 97, TA 98, TA 100, TA 102), but also have different degrees of obstructing mutagenesis induced by Furapromidum (F30066), Zhengdingmycin Hydrochloride (DM), N-methyl-N1-nitro-N-nitrosoguanidine (MNNG) and Methyl-methanesulfonate (MMS). The blockage effect of GU and CM obviously depends on the doses used. GU and CM could also impede the occurrence of stomach cancer induced by MNNG, and the impeding rate is about sixty percent.
Shi
G Z
GZ
Beijing Institute for Cancer Research.
D016604:Aflatoxin B1; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D004249:DNA Damage / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006035:Glycyrrhiza; D008297:Male; D008769:Methylnitronitrosoguanidine; D016296:Mutagenesis / Q000187:drug effects*; D010946:Plants, Medicinal; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000235:genetics; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000517:prevention & control*
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D008769:Methylnitronitrosoguanidine; D016604:Aflatoxin B1