CD4+, CD33-, CD13-, CD14- acute monoblastic leukaemia.
We report a case of acute monoblastic leukaemia in which the expression of the CD4 antigen occurred in the absence of myeloid and monocytic lineage specific markers. Unexpected marker profiles have biological and diagnostic implications and we also suggest that the inappropriate expression of the CD4 antigen may be implicated in the poor prognosis of this case.
Lombard
E H
EH
Department of Haematological Pathology, University of Stellenbosch, Tygerberg, South Africa.
Mansvelt
E P
EP
D000293:Adolescent; D015703:Antigens, CD / Q000032:analysis*; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis / Q000235:genetics; D018826:CD13 Antigens; D015704:CD4 Antigens / Q000032:analysis*; D006801:Humans; D016130:Immunophenotyping; D007948:Leukemia, Monocytic, Acute / Q000276:immunology*; D018950:Lipopolysaccharide Receptors; D008297:Male; D063268:Sialic Acid Binding Ig-like Lectin 3
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D000954:Antigens, Surface; C571163:CD33 protein, human; D015704:CD4 Antigens; D018950:Lipopolysaccharide Receptors; D063268:Sialic Acid Binding Ig-like Lectin 3; D018826:CD13 Antigens