Lymphocyte subset and NK activity in cervical intra-epithelial neoplasia.
We have studied the systemic T-lymphocyte subset and, in particular, the natural-killer (NK) activity in 23 patients with cervical intra-epithelial neoplasia (CIN), and 11 controls (a history of normal cervical PAP smears and colposcopy patterns). The lymphocyte phenotypes were studied using a panel of monoclonal antibodies, and NK activity was evaluated as the percentage lysis of K 562 target cells. In patients with CIN we found a significant decrease in NK activity (p = 0.002) which was directly correlated with the grade of CIN, with no alterations in the absolute number of NK cells.
Garzetti
G G
GG
Department of Obstetrics and Gynaecology, University of Ancona, Italy.
Cignitti
M
M
Ciavattini
A
A
Fabris
N
N
Romanini
C
C
D000328:Adult; D003127:Colposcopy; D003276:Contraceptives, Oral; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007694:Killer Cells, Natural / Q000737:chemistry*; D016131:Lymphocyte Subsets / Q000737:chemistry*; D009367:Neoplasm Staging; D065006:Papanicolaou Test; D010298:Parity; D012907:Smoking / Q000453:epidemiology; D016176:T-Lymphocyte Subsets / Q000737:chemistry; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000473:pathology; D014626:Vaginal Smears
D003276:Contraceptives, Oral