title: Histochemistry of NADPH-diaphorase, a marker for neuronal nitric oxide synthase, in the peripheral autonomic nervous system of the mouse.
abstract: In order to identify possible sites of synthesis of nitric oxide in the peripheral nervous system, several mouse organs were investigated for the presence of NADPH-diaphorase activity. Diaphorase-positive neurons and fibers were localized in the tongue, submandibular salivary glands, gastrointestinal and biliary duct systems, lower urinary tract and pelvic ganglia. By thionin counterstaining it was found that a distinct subpopulation of neurons was labeled. The present study indicates that nitric oxide synthase may be present in intrinsic neurons of various organs, suggesting a widespread function of nitric oxide in the peripheral autonomic nervous system.
authors.affiliation: Department of Anatomy, Free University of Berlin, F.R.G.
authors.forename: Z
authors.initials: Z
authors.lastname: Grozdanovic
authors.forename: H G
authors.initials: HG
authors.lastname: Baumgarten
authors.forename: G
authors.initials: G
authors.lastname: Brüning
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000032:analysis / Q000378:metabolism*; D000818:Animals; D001341:Autonomic Nervous System / Q000201:enzymology*; D015415:Biomarkers; D004064:Digestive System / Q000294:innervation; D005260:Female; D005704:Gallbladder / Q000294:innervation; D005725:Ganglia, Autonomic / Q000166:cytology / Q000201:enzymology*; D006651:Histocytochemistry; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009252:NADPH Dehydrogenase / Q000032:analysis / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000201:enzymology*; D019001:Nitric Oxide Synthase; D010614:Pharynx / Q000294:innervation; D013363:Submandibular Gland / Q000294:innervation; D014059:Tongue / Q000294:innervation; D014551:Urinary Tract / Q000294:innervation
chemical_list: D015415:Biomarkers; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases; D009252:NADPH Dehydrogenase