title: Genetic affinities of oceanic populations based on RFLP and haplotype analysis of genetic loci on three chromosomes.
abstract: Restriction fragment length polymorphisms at the renin and factor 13B loci located at chromosome 1q32-1q42 were studied in 14 ethnic groups in the west Pacific region. The allele frequencies were combined with previously described beta-globin and albumin-vitamin D binding protein haplotype frequencies and used to assess genetic affinities among eight major ethnic-geographic groups in this region. These population groups divide into two clusters with Australian Aborigines, Island Melanesians, and Highland Melanesians forming one cluster and east Asians, Southeast Asians, Micronesians, and Polynesians forming the other. The results indicate that Micronesians and Polynesians are derived from populations in Southeast Asia and that they originated independently of the Melanesian populations.
authors.affiliation: Human Genetics Group, John Curtin School of Medical Research, Australian National University, Canberra, ACT.
authors.forename: L Z
authors.initials: LZ
authors.lastname: Chen
authors.forename: S
authors.initials: S
authors.lastname: Easteal
authors.forename: P G
authors.initials: PG
authors.lastname: Board
authors.forename: R L
authors.initials: RL
authors.lastname: Kirk
mesh_terms: D001609:Beta-Globulins / Q000235:genetics; D015139:Blotting, Southern; D002878:Chromosomes, Human, Pair 1; D005006:Ethnicity / Q000235:genetics*; D005176:Factor XIII / Q000235:genetics*; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D010139:Pacific Islands; D012150:Polymorphism, Restriction Fragment Length; D012083:Renin / Q000235:genetics*; D014809:Vitamin D-Binding Protein / Q000235:genetics
chemical_list: D001609:Beta-Globulins; D014809:Vitamin D-Binding Protein; D005176:Factor XIII; D012083:Renin