All-trans retinoic acid in acute promyelocytic leukemia: preliminary results in Cuba.
Seven patients with acute promyelocytic leukemia (APL) were treated with all-trans retinoic acid (ATRA). Five (71.4%) achieved complete remission (CR). Most side effects were transient and well tolerated. Hyperleukocytosis was the major adverse effect. These observations confirm the efficacy of ATRA for inducing CR in APL.
Hernández
P
P
Instituto de Hematologia e Inmunologia, Ciudad de La Habana, Cuba.
Carnot
J
J
Dorticós
E
E
Espinosa
E
E
González
A
A
Rodríguez
I
I
D000328:Adult; D003462:Cuba; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy*; D008297:Male; D013237:Stereoisomerism; D014212:Tretinoin / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*
D014212:Tretinoin