Carbohydrate changes in colon carcinoma.
The colonic epithelium preferentially expresses only certain types of carbohydrate antigens. The most prevalent ones are the lacto-series type 1 (Gal beta 1,3GlcNAc) and type 2 (Gal beta 1,4GlcNAc) chain blood group-related substances, which can reside on both glycolipids and glycoproteins, and mucin-type O-linked structures such as Tn, T, and sialosyl-Tn, which reside exclusively on glycoproteins. This review focuses on the tissue expression in the colon of those carbohydrate tumour-associated antigens which have been most extensively studied and for which the epitope structure has been defined.
Itzkowitz
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Gastrointestinal Research Laboratory, Mount Sinai School of Medicine, New York, N.Y.
D000017:ABO Blood-Group System / Q000737:chemistry* / Q000378:metabolism; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000737:chemistry* / Q000378:metabolism; D002240:Carbohydrate Sequence; D002277:Carcinoma / Q000737:chemistry* / Q000378:metabolism; D003110:Colonic Neoplasms / Q000737:chemistry* / Q000378:metabolism; D000939:Epitopes; D006031:Glycosylation; D006801:Humans; D007983:Lewis Blood Group Antigens / Q000737:chemistry* / Q000378:metabolism; D008969:Molecular Sequence Data; D009077:Mucins / Q000737:chemistry / Q000378:metabolism
D000017:ABO Blood-Group System; D015295:Antigens, Tumor-Associated, Carbohydrate; D000939:Epitopes; D007983:Lewis Blood Group Antigens; D009077:Mucins