title: Thrombelastography after aspirin ingestion in pregnant and non-pregnant subjects.
abstract: The thrombelastograph (TEG) and bleeding time were performed before and 6 h after a single oral dose of aspirin 600 mg in a group of eight healthy volunteers and 12 pregnant patients. Measured TEG variables (r, k, r+k times and maximum amplitude) were unaltered after aspirin although there was a significant prolongation of the bleeding time in both groups. Although the TEG appeared not to detect aspirin-induced changes in platelet function, the TEG measures all phases of coagulation and the unaltered TEG after aspirin suggested a functioning coagulation system.
authors.affiliation: Department of Anaesthetics, Faculty of Medicine, University of Natal, Durban, South Africa.
authors.forename: C E
authors.initials: CE
authors.lastname: Orlikowski
authors.forename: A J
authors.initials: AJ
authors.lastname: Payne
authors.forename: J
authors.initials: J
authors.lastname: Moodley
authors.forename: D A
authors.initials: DA
authors.lastname: Rocke
mesh_terms: D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology*; D001760:Bleeding Time; D001777:Blood Coagulation / Q000187:drug effects*; D001792:Blood Platelets / Q000187:drug effects; D005260:Female; D006801:Humans; D011247:Pregnancy / Q000097:blood*; D013916:Thrombelastography
chemical_list: D001241:Aspirin