title: Effects of neonatal enucleation on catecholamine and serotonin turnover and amino acid levels in lateral geniculate nucleus and visual cortex of the adult rat.
abstract: Changes in turnover of dopamine (DA), noradrenaline (NA) and serotonin (5-hydroxytryptamine (5-HT)) and their metabolites, together with amino acid content, have been studied in dorsal lateral geniculate nucleus (LGNd) and visual cortex (VC) of neonatal enucleated rats. Enucleation increases the 5-HT turnover in LGNd and catecholamine turnover in VC. In contrast, enucleation decreases glutamate (and/or aspartate) content in LGNd and gamma-aminobutyric acid (GABA) in VC. These changes suggest an increase of the inhibitory action of the biogenic amines in LGNd after neonatal enucleation. The decrease of GABA in VC may reflect the importance of GABA in intracortical circuitry.
authors.affiliation: Departamento de Bioquimica, Bromatologia y Toxicologia, Universidad de Sevilla, Spain.
authors.forename: M L
authors.initials: ML
authors.lastname: Vizuete
authors.forename: V
authors.initials: V
authors.lastname: Steffen
authors.forename: A
authors.initials: A
authors.lastname: Machado
authors.forename: J
authors.initials: J
authors.lastname: Cano
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D002395:Catecholamines / Q000378:metabolism*; D005829:Geniculate Bodies / Q000378:metabolism*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D014793:Visual Cortex / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D002395:Catecholamines; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid