Sialogogic effects on rat submandibular gland of analogs of the C-terminal hexapeptide of substance P.
The sialogogic response of submandibular glands to analogs of the C-terminal hexapeptide of substance P with various amino acids at the N-terminus was investigated in urethane-anesthetized rats. The rank order of potencies was as follows: SP greater than (pGlu6)SP6-11 much greater than (Dab6)SP6-11 greater than (Orn6)SP6-11 greater than (Gln6)SP6-11 greater than (Lys6)SP6-11 much greater than (Ala6)SP6-11. These results suggest that the sialogogic activity of the analogs of the C-terminal hexapeptide is influenced by the steric effects of the N-terminal amino acid, and the nature of its side chain is of particular importance.
Iwabuchi
Y
Y
Department of Dental Pharmacology, School of Dentistry, Nippon Dental University, Japan.
Masuhara
T
T
Sofuku
S
S
D000818:Animals; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D051381:Rats; D011919:Rats, Inbred Strains; D012472:Salivation / Q000187:drug effects*; D013363:Submandibular Gland / Q000187:drug effects / Q000378:metabolism*; D013373:Substance P / Q000031:analogs & derivatives / Q000494:pharmacology*
D010446:Peptide Fragments; D013373:Substance P; C032292:substance P (6-11); C026238:substance P (6-11), pGlu(6)-; D011761:Pyrrolidonecarboxylic Acid