K+ channel activator inhibition of neurogenic goblet cell secretion in guinea pig trachea.
A potassium (K+) channel activator, BRL 38227, inhibited goblet cell secretion in guinea-pig trachea induced by either electrical stimulation of the vagus nerves or acute inhalation of cigarette smoke, two stimuli which activate both cholinergic nerves and capsaicin-sensitive sensory nerves. BRL 38227 failed to inhibit methacholine- or substance P-induced goblet cell secretion which suggests that K+ channel activators inhibit neurogenic goblet cell secretion via a prejunctional effect on cholinergic and sensory nerves.
Kuo
H P
HP
Department of Thoracic Medicine, National Heart and Lung Institute, London, UK.
Rohde
J A
JA
Barnes
P J
PJ
Rogers
D F
DF
D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D001993:Bronchodilator Agents / Q000494:pharmacology*; D019806:Cromakalim; D004558:Electric Stimulation; D006168:Guinea Pigs; D008297:Male; D008688:Methacholine Compounds / Q000037:antagonists & inhibitors / Q000494:pharmacology; D015221:Potassium Channels / Q000187:drug effects*; D011758:Pyrroles / Q000494:pharmacology*; D012907:Smoking / Q000503:physiopathology; D013373:Substance P / Q000037:antagonists & inhibitors / Q000494:pharmacology; D014132:Trachea / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D014630:Vagus Nerve / Q000502:physiology
D001578:Benzopyrans; D001993:Bronchodilator Agents; D008688:Methacholine Compounds; D015221:Potassium Channels; D011758:Pyrroles; D019806:Cromakalim; D013373:Substance P