title: Efficacy of prostate-specific antigen and magnetic resonance imaging in staging stage C adenocarcinoma of the prostate.
abstract: OBJECTIVE
  The authors compared the two most common presurgical tests now used for the preoperative staging of adenocarcinoma of the prostate, prostate-specific antigen (PSA) and magnetic resonance imaging (MRI).
  
  
  METHODS
  One hundred consecutive radical retropubic prostatectomy patients were imaged at 1.5 Tesla before surgery with routine T1-weighted and T2-weighted transaxial images. The images were analyzed by two experienced radiologists for evidence of extracapsular disease. Radiologists rated each gland on a scale of 0 to 100 for the percentage likelihood of extracapsular disease based on its MRI appearance. Receiver operator characteristic (ROC) curves were plotted, and areas were calculated for the two radiologists and the preoperative PSA values.
  
  
  RESULTS
  Comparison of the areas of the ROC curves generated from the two radiologists and those from the preoperative PSA values showed no statistical difference.
  
  
  CONCLUSIONS
  In this series, radiologic interpretation of body coil MRI studies in those patients chosen for a radical retropubic prostatectomy was no better in staging adenocarcinoma of the prostate than simply using the preoperative PSA values.
authors.affiliation: Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia 19104.
authors.forename: M L
authors.initials: ML
authors.lastname: Schiebler
authors.forename: B C
authors.initials: BC
authors.lastname: Yankaskas
authors.forename: C
authors.initials: C
authors.lastname: Tempany
authors.forename: P
authors.initials: P
authors.lastname: Holtz
authors.forename: E
authors.initials: E
authors.lastname: Zerhouni
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000097:blood*; D001706:Biopsy; D005069:Evaluation Studies as Topic; D005189:False Positive Reactions; D006801:Humans; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000706:statistics & numerical data; D008297:Male; D009367:Neoplasm Staging; D011467:Prostate / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000473:pathology*; D012372:ROC Curve
chemical_list: D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen