[Brain-stem auditory pathways: effects of atropine].
The efferent pathways exert a control action on the function of the cochlear nucleus and hair cells. Acetylcholine is the neurotransmitter of the centrifugal system and its action can be blocked by Atropine. In order to give a contribution to the knowledge of the function of the efferent bundle, Auditory Brainstem Responses (ABRs) and Acoustic Reflex Latencies (ARLs) have been examined in 10 young normal subjects there was also a decrease in latency greater than or equal to 100 microseconds by at least other two waves. The only statistically significant difference was relative to the latency mean value of the wave III recorded in contralateral derivation at 11 pps. The ARLs, after the infusion of atropine, showed a statistically significant increase in 7 of the 10 cases; no change was recorded in the AR amplitude. It can be concluded that the pharmacological block of the olivo-cochlear bundle determines a delay in the neural conduction of the acoustic impulses; this finding means that the atropine can inhibit the facilitating activity of the efferent system on the brainstem afferent pathways.
Salonna
I
I
Centro di Audiologia e Otologia, Università degli Studi di Bari.
Bartoli
R
R
Quaranta
A
A
D000109:Acetylcholine / Q000502:physiology; D000293:Adolescent; D000328:Adult; D000344:Afferent Pathways / Q000502:physiology; D001285:Atropine / Q000494:pharmacology*; D001306:Auditory Pathways / Q000187:drug effects*; D003056:Cochlear Nerve / Q000187:drug effects / Q000502:physiology; D003864:Depression, Chemical; D004525:Efferent Pathways / Q000187:drug effects / Q000502:physiology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D009847:Olivary Nucleus / Q000187:drug effects / Q000502:physiology; D011930:Reaction Time / Q000187:drug effects; D012022:Reflex, Acoustic / Q000187:drug effects*
D001285:Atropine; D000109:Acetylcholine