title: Phase response curve to anisomycin in tau mutant hamsters.
abstract: Administration of the protein synthesis inhibitor, anisomycin, to wild type hamsters produces phase shifts in their circadian rhythms that have similarities to shifts produced by non-photic behavioral stimulation. A mutation that shortens the period of rhythms in hamsters results in altered responsiveness to non-photic input. However, responses of the mutants to anisomycin are unaffected: their phase response curve (PRC) for anisomycin is similar to that of wild types. This suggests that 1) anisomycin is not acting on mechanisms specifically involved in non-photic behavioral phase shifting, and 2) the mutation affects the non-photic input pathway or the pacemaker itself at a point that is upstream from anisomycin's site of action.
authors.affiliation: Department of Zoology, University of Toronto, Ontario, Canada.
authors.forename: N
authors.initials: N
authors.lastname: Mrosovsky
authors.forename: M R
authors.initials: MR
authors.lastname: Ralph
mesh_terms: D000818:Animals; D000841:Anisomycin / Q000494:pharmacology*; D002940:Circadian Rhythm / Q000187:drug effects*; D006224:Cricetinae; D008027:Light; D008297:Male; D008647:Mesocricetus; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009154:Mutation
chemical_list: D000841:Anisomycin