Clonazepam treatment of myoclonic contractions associated with high-dose opioids: case report.
A 30-year-old man with chronic abdominal pain was treated with high doses of hydromorphone intravenously and developed severe and frequent myoclonic contractions. Several medications including lorazepam failed to control the contractions; however, clonazepam in normal doses reduced the myoclonus dramatically.
Eisele
John H
JH
Department of Anesthesiology Pain Service, University of California at Davis, Sacramento, CAUSA Cancer Center Pharmacy, University of California Davis Medical Center, Sacramento, CAUSA.
Grigsby
Eric J
EJ
Dea
Gilland
G
D000328:Adult; D002998:Clonazepam / Q000627:therapeutic use*; D006801:Humans; D004091:Hydromorphone / Q000009:adverse effects*; D008140:Lorazepam / Q000627:therapeutic use; D008297:Male; D009207:Myoclonus / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology
D002998:Clonazepam; D008140:Lorazepam; D004091:Hydromorphone