title: Mental and physical state in subclinical hyperthyroidism: investigations in a normal working population.
abstract: We investigated whether subclinically hyperthyroid individuals selected from a nonpatient working population exhibit similar impairments to those found in studies with patients. Sixteen subclinically hyperthyroid subjects without apparent reason (SH-0) and 15 subclinically hyperthyroid subjects on levothyroxine (SH-T4) were compared with 27 euthyroid controls with respect to signs and symptoms of hyperthyroidism, sleep, depressivity, ability to concentrate, anxiety, and other dimensions of well-being. We found that SH-T4 exhibited significantly higher TT4 levels, TT4/TBG ratios, and more palpitations than controls. Furthermore, they slept less. The SH-0 subjects reported being in a better mood and less touchy than controls. Psychometric results of all groups were within the normal range. A comparison of this study to previous studies reveals that TT4 levels or TT4/TBG ratios may play a crucial role in the development of the predominantly nervous symptoms in subclinical hyperthyroidism. Possible reasons for the discrepancies between results in hospital and nonhospital settings are discussed.
authors.affiliation: Berufsgenossenschaft für Nährungsmittel und Gaststätten (Social Corporation of Food and Catering) Mannheim, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Schlote
authors.forename: L
authors.initials: L
authors.lastname: Schaaf
authors.forename: R
authors.initials: R
authors.lastname: Schmidt
authors.forename: T
authors.initials: T
authors.lastname: Pohl
authors.forename: I
authors.initials: I
authors.lastname: Vardarli
authors.forename: H
authors.initials: H
authors.lastname: Schiebeler
authors.forename: M A
authors.initials: MA
authors.lastname: Zober
authors.forename: K H
authors.initials: KH
authors.lastname: Usadel
mesh_terms: D000328:Adult; D001143:Arousal / Q000502:physiology; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000175:diagnosis / Q000517:prevention & control* / Q000523:psychology; D008297:Male; D008403:Mass Screening; D019965:Neurocognitive Disorders / Q000175:diagnosis / Q000523:psychology; D010555:Personality Inventory; D012803:Sick Role; D012894:Sleep Stages / Q000502:physiology; D013963:Thyroid Hormones / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone
chemical_list: D013963:Thyroid Hormones; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin