Transfer of 125I-albumin from blood to brain in newborn rats and the effect of hyperbilirubinemia on the transfer.
Transfer of albumin from blood into cerebellum and cerebrum was examined in postnatal rats. 125I-Albumin was injected into rats on day 3, 7, 14, 28 or 70. The ratio of albumin concentration in the cerebellum or in the cerebrum to that in the plasma 2 h after the injection, hereinafter termed the relative albumin level (RA), was calculated and used as a criterion for the albumin transfer. The RA in both the cerebellum and the cerebrum decreased with age, but plateaued between days 28 and 70. The level was significantly higher in the cerebellum than in the cerebrum on days 3 and 7. This was not observed, however, on days 28 and 70. Significant correlations were indicated between 125I-albumin levels in the plasma and those in the cerebellum or cerebrum on days 7 and 14, but not on day 28. No significant difference in the RA in the cerebellum and the cerebrum was detected between jaundiced homozygous Gunn rats and control nonjaundiced rats at all ages examined. These results demonstrated that albumin could enter the brain tissue from the blood at least until postnatal day 14 and that the endogenous bilirubin had no effect on the albumin transfer into the brain. The relationship between the immaturity of brain and the transfer of albumin into the brain was discussed.
Ohsugi
M
M
Department of Anatomy, Mie University School of Medicine, Tsu, Japan.
Sato
H
H
Yamamura
H
H
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001693:Biological Transport, Active; D001812:Blood-Brain Barrier / Q000502:physiology*; D001921:Brain / Q000378:metabolism; D002531:Cerebellum / Q000378:metabolism; D005260:Female; D006932:Hyperbilirubinemia / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D051381:Rats; D011911:Rats, Gunn; D012709:Serum Albumin / Q000378:metabolism*
D012709:Serum Albumin