Proteinase inhibitory activity in the plasma of a mollusc: evidence for the presence of alpha-macroglobulin in Biomphalaria glabrata.
1. A methylamine-sensitive inhibitor was present in the plasma of B. glabrata. 2. This inhibitor decreased trypsin activity against a protein substrate, however trypsin retained activity against a low molecular weight substrate in the presence of the inhibitor. 3. Snail plasma protected trypsin from inhibition by soybean trypsin inhibitor. 4. The results give evidence for an alpha-macroglobulin proteinase inhibitor in the plasma of this gastropod mollusc.
Bender
R C
RC
Department of Zoology, Oregon State University, Corvallis 97331-2914.
Fryer
S E
SE
Bayne
C J
CJ
D000818:Animals; D001700:Biomphalaria / Q000201:enzymology*; D006454:Hemoglobins / Q000302:isolation & purification; D011480:Protease Inhibitors / Q000097:blood*; D014361:Trypsin Inhibitors / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000032:analysis*
D006454:Hemoglobins; D011480:Protease Inhibitors; D014361:Trypsin Inhibitors; D000511:alpha-Macroglobulins