title: [Chief cell mass in gastric ulcer: cyto-secretory correlations].
abstract: The aim of this experience has been to evaluate the chief cell mass and serum pepsinogen I in gastric ulcer patients. Comparisons were also made with parietal cell mass and acid secretion. Chief cell mass and serum pepsinogen I are not only influenced by the localization of ulcer but, also, by the histological condition of fundic mucosa. In fact, the behaviour of serum pepsinogen I and chief cell mass in type I gastric ulcer is the same observed in case of fundic chronic gastritis without gastric ulcer. In case of gastric ulcer type I with superficial fundic gastritis it emerges normozymogenism with hyperpepsinogenemia++ I, with preatrophic fundic gastritis hypozymogenism with normopepsinogenemia, with atrophic fundic gastritis hypozymogenism with hypopepsinogenemia I. In type II and III gastric ulcer the chief cell mass and serum pepsinogen I behaviour as they do in duodenal ulcer with hyperpepsinogenemia although hypozymogenism is present.
authors.affiliation: Divisione di Gastroenterologia ed Endoscopia Digestiva, Ospedale S. Martino, Genova.
authors.forename: A
authors.initials: A
authors.lastname: Perasso
authors.forename: G
authors.initials: G
authors.lastname: Testino
mesh_terms: D000328:Adult; D000368:Aged; D010131:Aminosalicylic Acid; D001706:Biopsy; D004792:Enzyme Precursors / Q000032:analysis; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005748:Gastric Fundus / Q000473:pathology; D005753:Gastric Mucosa / Q000473:pathology; D005756:Gastritis / Q000097:blood / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010295:Parietal Cells, Gastric; D010435:Pepsinogens / Q000097:blood*; D013276:Stomach Ulcer / Q000097:blood / Q000473:pathology*
chemical_list: D004792:Enzyme Precursors; D010435:Pepsinogens; D010131:Aminosalicylic Acid