8-Methoxypsoralen blocks ATP-sensitive potassium channels and stimulates insulin release.
8-Methoxypsoralen (8-MOP) stimulated insulin release from HIT-T15 B-cells and inhibited the diazoxide-induced and sulfonylurea-sensitive 86Rb+ efflux from these cells. These results indicate that 8-MOP affects ATP-sensitive K+ channel activity. Patch-clamp experiments confirmed this view.
Szewczyk
A
A
Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France.
De Weille
J R
JR
Lazdunski
M
M
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D006168:Guinea Pigs; D007328:Insulin / Q000378:metabolism*; D007340:Insulinoma / Q000378:metabolism; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism; D008730:Methoxsalen / Q000494:pharmacology*; D015221:Potassium Channels / Q000187:drug effects*; D012414:Rubidium Radioisotopes; D014407:Tumor Cells, Cultured
D007328:Insulin; D015221:Potassium Channels; D012414:Rubidium Radioisotopes; D000255:Adenosine Triphosphate; D008730:Methoxsalen