title: Lethal effects of ivermectin on Anopheles quadrimaculatus.
abstract: Female Anopheles quadrimaculatus adults were blood fed on 15 mixed breed dogs 4 h after the dogs were given oral dosages of ivermectin. Dogs were divided into 5 treatment groups of 3 dogs each, at 10, 500, 1,000, 2,500 micrograms/kg, and untreated. Additionally, An. quadrimaculatus were fed on lambskin-membranes containing blood drawn from one dog in each treatment group. Mosquitoes were allowed to feed on the dogs or the lambskin-membranes and were observed for death at 24 and 48 h post-feeding. Greater than 90% mortality was recorded in all ivermectin treatment groups except at the 24 h post-feeding period with the 10 micrograms/kg dog dose blood fed through the lambskin-membrane (65.4% mortality). The highest 2 dosages produced 100% mosquito mortality at 48 h post-feeding from either a dog or the in vitro system using a lambskin-membrane.
authors.affiliation: Department of Entomology, University of Arkansas, Fayetteville 72701.
authors.forename: J W
authors.initials: JW
authors.lastname: Jones
authors.forename: M V
authors.initials: MV
authors.lastname: Meisch
authors.forename: C L
authors.initials: CL
authors.lastname: Meek
authors.forename: W S
authors.initials: WS
authors.lastname: Bivin
mesh_terms: D000818:Animals; D000852:Anopheles; D004285:Dogs; D005260:Female; D007559:Ivermectin / Q000097:blood; D009032:Mosquito Control / Q000379:methods*
chemical_list: D007559:Ivermectin