Stimulation in the ventral posterior lateral nucleus of the primate thalamus leads to release of serotonin in the lumbar spinal cord.
Stimulation in the ventrobasal complex of the thalamus relieves neuropathic pain and inhibits spinal cord transmission of nociceptive information. Electrical stimulation of the ventral posterior nucleus of the thalamus elicited increases in extracellular serotonin concentration in the spinal cords of anesthetized monkeys. These results suggest that thalamic stimulation activates the raphe-spinal tract and thus implicates serotonin as a mediator of thalamic stimulation induced analgesia.
Sorkin
L S
LS
Marine Biomedical Institute, University of Texas Medical Branch, Galveston 77550.
McAdoo
D J
DJ
Willis
W D
WD
D000818:Animals; D001931:Brain Mapping; D003956:Dialysis / Q000379:methods; D004558:Electric Stimulation; D007700:Kinetics; D008252:Macaca fascicularis; D010146:Pain / Q000503:physiopathology*; D012701:Serotonin / Q000378:metabolism*; D013116:Spinal Cord / Q000502:physiology*; D013787:Thalamic Nuclei / Q000502:physiology*
D012701:Serotonin