title: Iloprost reduces peripheral resistance during femoro-distal reconstruction.
abstract: A randomised placebo-controlled trial was conducted to investigate the effect of iloprost, a stable prostacyclin mimetic, on peripheral resistance during femoro-distal bypass. Patients undergoing femoro-distal long saphenous vein bypass for critical ischaemia received 3000 ng of iloprost or placebo infused into the graft via an unligated side branch over 2 min. Graft blood flow and peripheral resistance were measured for 20 min, using an operative Doppler flowmeter (OpDop 130, SciMed, U.K.) and a pressure transducer to record graft pressure. Postoperatively, graft blood flow was assessed by daily duplex ultrasound for 7 days. Iloprost produced an immediate drop in peripheral resistance in all cases (n = 18) by a mean (range) of 40% (4-80%) compared with controls (n = 15) in whom there was a 5.3% (-8 to +36%) increase in resistance (p less than 0.01, Wilcoxon test). Decreased peripheral resistance in iloprost-treated patients persisted to 20 min. The largest decreases in peripheral resistance occurred in patients with the highest initial resistances (r = 0.56, p less than 0.02). Graft flow during the same period increased by 52% (-7 to 294%) compared with controls in whom there was a 6% (-17 to 26%) increase in flow, (p less than 0.01). Flow remained elevated by 53% over baseline values at 1 week post-infusion in the iloprost-treated group but this did not achieve statistical significance compared to controls in whom flow also increased by 13%. Iloprost produces an immediate decrease in peripheral resistance associated with a prolonged increase in graft blood flow. This may reduce graft failure in the early postoperative period.
authors.affiliation: University Department of Vascular Surgery, Queen Elizabeth Hospital, Edgbaston, Birmingham, U.K.
authors.forename: F C
authors.initials: FC
authors.lastname: Smith
authors.forename: G M
authors.initials: GM
authors.lastname: Tsang
authors.forename: H R
authors.initials: HR
authors.lastname: Watson
authors.forename: C P
authors.initials: CP
authors.lastname: Shearman
mesh_terms: D000368:Aged; D000714:Anastomosis, Surgical; D004334:Drug Administration Schedule; D005260:Female; D005263:Femoral Artery / Q000601:surgery*; D006801:Humans; D016285:Iloprost / Q000008:administration & dosage / Q000494:pharmacology*; D007432:Intraoperative Period; D007511:Ischemia / Q000503:physiopathology / Q000601:surgery*; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D014655:Vascular Resistance / Q000187:drug effects*
chemical_list: D016285:Iloprost