Somatic cell mapping of T-cell receptor CD3 complex and CD8 genes in cattle.
Bovine genes encoding T-cell receptor, CD3, and CD8 molecules have been mapped to syntenic groups using bovine x rodent hybrid somatic cells. T-cell receptor alpha and delta chains were assigned to bovine syntenic group U5, and the beta and gamma genes were syntenic with each other and with markers on U13. CD3E and CD3D genes were syntenic with each other and located to bovine syntenic group U19. CD8 was most concordant with markers of syntenic group U16, although the concordancy was only 85% and the assignment must be regarded as tentative. The comparative gene maps of human chromosome 7, bovine syntenic group U13, and mouse chromosomes 6 and 13 suggest extensive evolutionary conservation.
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Department of Veterinary Pathobiology, Texas A&M University, College Station 77843.
Teale
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Bensaid
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Dunlap
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Dietz
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Womack
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D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics*; D005075:Biological Evolution; D015139:Blotting, Southern; D017252:CD3 Complex; D016827:CD8 Antigens / Q000235:genetics*; D002417:Cattle / Q000235:genetics* / Q000276:immunology; D002874:Chromosome Mapping; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA; D015342:DNA Probes; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*
D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D016827:CD8 Antigens; D015342:DNA Probes; D011948:Receptors, Antigen, T-Cell; D004247:DNA