Variability of serum levels for three oral 8-methoxypsoralen brands.
We conducted a pilot study to investigate the serum level patterns of 3 commercial and internationally introduced 8-methoxypsoralen (8-MOP) preparations in 9 patients for their bioequivalence and registered the interindividual variability of serum levels over 8 h after intake of 30 mg 8-MOP equivalent doses. On average, the highest serum levels (Cmax 120.1, range 235-61 ng.ml-1) were reached as early as 0.5-1 h after ingestion of Geroxalen soft gelatin capsules, whereas lower serum levels were seen after intake of the Oxsoralen hard gelatin capsules (Cmax 82.3, range 154-47 ng.ml-1) and the Mopsoralen tablets (Cmax 81.3, range 172-26 ng.ml-1). The importance of 8-MOP serum level determination for better and efficient PUVA therapy is discussed.
Walther
T
T
Department of Dermatology, University of Leipzig, Germany.
Quednow
B
B
Haustein
U F
UF
Meyer
F P
FP
D000328:Adult; D001835:Body Weight; D006801:Humans; D008730:Methoxsalen / Q000493:pharmacokinetics*; D010865:Pilot Projects
D008730:Methoxsalen