title: cDNA sequence of human p11 calpactin I light chain.
abstract: The cDNA encoding full-length human p11 calpactin I light chain has been cloned and subjected to DNA sequencing. The open reading frame specifies a 97-amino-acid residue protein that surprisingly is identical to the p11 sequences of two mammalian ungulate species, cow and pig. However, the previously reported p11 polypeptide sequences of mouse and rat exhibited 8-9% nonidentity to human p11. These mammalian sequence comparison results are unexpected in view of current molecular cladistic theories that suggest a closer relationship between primates and rodents, rather than primates and ungulates. The mouse p11 gene has been previously mapped to chromosome 3 at a position syntenic with a centromeric-proximal region on human chromosome 1, and the human p11 cDNA clone is likely to be useful in physical mapping on chromosome 1.
authors.affiliation: Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78228.
authors.forename: T P
authors.initials: TP
authors.lastname: Dooley
authors.forename: K L
authors.initials: KL
authors.lastname: Weiland
authors.forename: M
authors.initials: M
authors.lastname: Simon
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017302:Annexins; D001483:Base Sequence; D002135:Calcium-Binding Proteins / Q000737:chemistry / Q000235:genetics*; D002417:Cattle; D004247:DNA / Q000235:genetics*; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D011487:Protein Conformation; D051381:Rats; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D013552:Swine
chemical_list: D017302:Annexins; D002135:Calcium-Binding Proteins; D004247:DNA