title: Deletions in the short arm of chromosome 8 are present in up to 90% of human colorectal cancer cell lines.
abstract: Cytogenetic analyses of human colon cancer cells have revealed non-random deletions in chromosome arm 8p, among other chromosomal changes. By using 8p-specific DNA probes we could identify allelic loss in 87% of colon cancer cell lines. Corresponding analyses in direct preparations of colon tumor tissues revealed a minimal value of 40% of allelic loss but were obstructed in many instances by contaminating normal tissue. These findings add to the number of non-random genetic alterations occurring during colon carcinogenesis.
authors.affiliation: Institut für Experimentelle Pathologie, Deutsches Krebsforschungszentrum, Heidelberg, Federal Republic of Germany.
authors.forename: K
authors.initials: K
authors.lastname: van der Bosch
authors.forename: I
authors.initials: I
authors.lastname: Becker
authors.forename: L
authors.initials: L
authors.lastname: Savelyeva
authors.forename: S
authors.initials: S
authors.lastname: Brüderlein
authors.forename: P
authors.initials: P
authors.lastname: Schlag
authors.forename: M
authors.initials: M
authors.lastname: Schwab
mesh_terms: D000483:Alleles; D002872:Chromosome Deletion; D002898:Chromosomes, Human, Pair 8 / Q000648:ultrastructure*; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D015342:DNA Probes; D004273:DNA, Neoplasm / Q000032:analysis; D005819:Genetic Markers; D006801:Humans; D014407:Tumor Cells, Cultured
chemical_list: D015342:DNA Probes; D004273:DNA, Neoplasm; D005819:Genetic Markers