title: Magnetic resonance imaging, microangiography, and histology in a rat model of primary liver cancer.
abstract: OBJECTIVE
  N-nitrosodiethylamine is able to induce various benign and malignant liver lesions in rats with a high success rate and a low mortality rate. It provides a more appropriate model that better simulates the various lesions occurring in patients than the usual model of tumor implantations.
  
  
  METHODS
  Hepatic carcinogenesis was induced in 58 Wistar rats using oral N-nitrosodiethylamine. The rats subsequently were studied by liver magnetic resonance imaging (MRI), postmortem microangiography, and histologic examination.
  
  
  RESULTS
  Hepatic tumors developed in 57 rats. A wide variety of the tumors in the degree of vascularization, the type of vessels, the areas of intratumoral secretion and necrosis, and the tumor cell differentiation resulted from the tumor model. The authors were able to assess the contribution of the vascular, extravascular, and cellular components in the final pattern of contrast enhancement in MRI.
  
  
  CONCLUSIONS
  The N-nitrosoethylamine model for hepatic tumor induction is simple, and provides a more representative range of tumors for experimental evaluation.
authors.affiliation: Department of Radiology, University Hospitals K.U. Leuven, Belgium.
authors.forename: Y
authors.initials: Y
authors.lastname: Ni
authors.forename: G
authors.initials: G
authors.lastname: Marchal
authors.forename: B
authors.initials: B
authors.lastname: van Damme
authors.forename: P
authors.initials: P
authors.lastname: van Hecke
authors.forename: J
authors.initials: J
authors.lastname: Michiels
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: J
authors.initials: J
authors.lastname: Yu
authors.forename: A L
authors.initials: AL
authors.lastname: Baert
mesh_terms: D000818:Animals; D003287:Contrast Media; D004052:Diethylnitrosamine; D004195:Disease Models, Animal; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods; D008297:Male; D008852:Microradiography / Q000379:methods; D051381:Rats; D017208:Rats, Wistar
chemical_list: D003287:Contrast Media; D004052:Diethylnitrosamine