Recombinant human granulocyte colony-stimulating factor promotes wound healing in a patient with congenital neutropenia.
We report a patient with congenital neutropenia or Kostmann's Syndrome who suffered many complications after presenting with Clostridium septicum enterocolitis, including absence of wound healing. Because of several reports of the use of granulocyte colony-stimulating factor (G-CSF) in patients with various complications of neutropenia, we treated this patient with recombinant human (rh) G-CSF. We found that once rhG-CSF restored neutrophil counts to normal, progressive wound healing followed. Thus, rhG-CSF therapy may be useful in treating neutropenic patients with wound complications.
Besner
G E
GE
Department of Surgery, School of Medicine and Biomedical Sciences, University at Buffalo, NY.
Glick
P L
PL
Karp
M P
MP
Wang
W C
WC
Lobe
T E
TE
White
C R
CR
Cooney
D R
DR
D000293:Adolescent; D004761:Enterocolitis, Pseudomembranous / Q000209:etiology / Q000601:surgery; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D009503:Neutropenia / Q000150:complications / Q000151:congenital / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000494:pharmacology / Q000627:therapeutic use; D013530:Surgical Wound Infection / Q000188:drug therapy* / Q000209:etiology; D014945:Wound Healing / Q000187:drug effects*
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor