WS9326A, a novel tachykinin antagonist isolated from Streptomyces violaceusniger no. 9326. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.
Data from several studies suggest that tachykinins may play an important role in the pathophysiology of airway diseases, especially asthma. Our aim is to discover tachykinin antagonists which exhibit therapeutically useful anti-asthmatic activity. In our search for activities inhibiting the binding of [3H]substance P to guinea-pig lung membrane preparations, we have found that the fermentation product, WS9326A, isolated from Streptomyces violaceusniger, is a potent tachykinin receptor antagonist.
Hayashi
K
K
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
Hashimoto
M
M
Shigematsu
N
N
Nishikawa
M
M
Ezaki
M
M
Yamashita
M
M
Kiyoto
S
S
Okuhara
M
M
Kohsaka
M
M
Imanaka
H
H
D000818:Animals; D001249:Asthma / Q000188:drug therapy; D005285:Fermentation; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008855:Microscopy, Electron, Scanning; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry; D013373:Substance P / Q000037:antagonists & inhibitors / Q000378:metabolism; D015320:Tachykinins / Q000037:antagonists & inhibitors*; D047630:Depsipeptides
D007783:Lactones; D010456:Peptides, Cyclic; D013373:Substance P; D015320:Tachykinins; C076469:WS 9326A; D047630:Depsipeptides; C075570:FK 224