The mitochondrial benzodiazepine receptor: evidence for association with the voltage-dependent anion channel (VDAC).
Specific, high-affinity receptors for numerous drugs have recently been localized to mitochondrial membrane proteins. This review discusses the association of the mitochondrial receptor for benzodiazepines (mBzR) with the voltage-dependent anion channel (VDAC), indicating a possible auxiliary role for VDAC as a putative drug binding protein. The proposed subunit composition of the purified mBzR complex isolated from rat kidney mitochondria includes VDAC, which functions as a recognition site for benzodiazepines (e.g., flunitrazepam), the adenine nucleotide carrier (ADC), and an 18 kDa outer membrane protein identified by covalent labelling with the mBzR antagonists isoquinoline carboxamides (e.g., PK14105).
McEnery
M W
MW
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
D000818:Animals; D007473:Ion Channels / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D018272:Porins; D011963:Receptors, GABA-A / Q000302:isolation & purification / Q000378:metabolism*; D050994:Voltage-Dependent Anion Channels
D007473:Ion Channels; D008565:Membrane Proteins; D018272:Porins; D011963:Receptors, GABA-A; D050994:Voltage-Dependent Anion Channels