Effect of stabilized hemoglobin as a component of cardioplegia on warm ischemic heart.
Stabilized hemoglobin was utilized as a component of cardioplegia in isolated rat heart. While oxygen consumption and heart function was better preserved in long term after reperfusion, damage from reperfusion injury was suspected and reversed in part by diltiazem.
Matsushita
S
S
Dept. of Surgery, University of Tsukuba, Ibaraki, Japan.
Sakakibara
Y
Y
Jikuya
T
T
Atsumi
N
N
Tsutsui
T
T
Okmamura
K
K
Ijima
H
H
Mitsui
T
T
Hori
M
M
D000818:Animals; D001802:Blood Substitutes / Q000627:therapeutic use* / Q000633:toxicity; D004110:Diltiazem / Q000627:therapeutic use; D006321:Heart / Q000187:drug effects / Q000502:physiology; D006324:Heart Arrest, Induced / Q000009:adverse effects / Q000379:methods*; D006439:Hemodynamics / Q000187:drug effects; D006454:Hemoglobins / Q000627:therapeutic use* / Q000633:toxicity; D066298:In Vitro Techniques; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy / Q000209:etiology; D010101:Oxygen Consumption / Q000187:drug effects; D011092:Polyethylene Glycols / Q000627:therapeutic use* / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism
D001802:Blood Substitutes; D006454:Hemoglobins; D017382:Reactive Oxygen Species; C050907:pyridoxalated-hemoglobin-polyethylene glycol conjugate; D011092:Polyethylene Glycols; D004110:Diltiazem