Anti-aids agents, 6. Salaspermic acid, an anti-HIV principle from Tripterygium wilfordii, and the structure-activity correlation with its related compounds.
Salaspermic acid [1], an inhibitor of HIV reverse transcriptase and HIV replication in H9 lymphocyte cells, was isolated from the roots of Tripterygium wilfordii for the first time. The structure of 1 derived from spectral data was established unequivocally by an X-ray analysis of crystals of the monohydrate. A structure-activity correlation of 1 with ten related compounds indicated that the acetal linkage in ring A and the carboxyl group in ring E of 1 may be required for the anti-HIV activity.
Chen
K
K
Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599.
Shi
Q
Q
Kashiwada
Y
Y
Zhang
D C
DC
Hu
C Q
CQ
Jin
J Q
JQ
Nozaki
H
H
Kilkuskie
R E
RE
Tramontano
E
E
Cheng
Y C
YC
D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D054303:HIV Reverse Transcriptase; D015497:HIV-1 / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000382:microbiology; D008968:Molecular Conformation; D010946:Plants, Medicinal / Q000737:chemistry*; D018894:Reverse Transcriptase Inhibitors; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*; D014961:X-Ray Diffraction
D000998:Antiviral Agents; D018894:Reverse Transcriptase Inhibitors; D014315:Triterpenes; C074717:salaspermic acid; D054303:HIV Reverse Transcriptase