Non-random abnormalities of chromosomes 3, 6, and 8 associated with posterior uveal melanoma.
We present ten cases of posterior uveal melanoma which were karyotyped after short-term culture. One tumour had a normal chromosome complement. The remaining nine tumours were cytogenetically abnormal, with chromosomes 3, 6, 8, 11, and 13 most frequently involved. Abnormalities of chromosome 13 were seen in two cases, chromosome 11 in three cases, and chromosomes 3, 6, and 8 in five cases. Four tumours, all derived from the ciliary body, demonstrated monosomy 3 and i(8q), confirming the involvement of these aberrations with a subgroup of uveal melanomas arising from the ciliary body.
Sisley
K
K
Department of Experimental and Clinical Microbiology, Sheffield University, Medical School, United Kingdom.
Cottam
D W
DW
Rennie
I G
IG
Parsons
M A
MA
Potter
A M
AM
Potter
C W
CW
Rees
R C
RC
D000368:Aged; D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11; D002882:Chromosomes, Human, Pair 13; D002893:Chromosomes, Human, Pair 3; D002896:Chromosomes, Human, Pair 6; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008545:Melanoma / Q000235:genetics*; D008875:Middle Aged; D014604:Uveal Neoplasms / Q000235:genetics*