title: Bleomycin-detectable iron in the plasma of premature and full-term neonates.
abstract: The bleomycin assay measures non-transferrin-bound iron, able to catalyze free radical reactions, in human plasma. No bleomycin-detectable iron is present in plasma from healthy adults. However, plasma from 3/15 premature babies was positive in this assay. Plasma from 52 apparently-healthy term babies was analyzed and 11 were positive in the bleomycin assay. Hence not only some premature but also some full-term apparently-healthy babies may be at risk of severe oxidative damage.
authors.affiliation: Department of Biochemistry, Kings College, London, UK.
authors.forename: P J
authors.initials: PJ
authors.lastname: Evans
authors.forename: R
authors.initials: R
authors.lastname: Evans
authors.forename: I Z
authors.initials: IZ
authors.lastname: Kovar
authors.forename: A F
authors.initials: AF
authors.lastname: Holton
authors.forename: B
authors.initials: B
authors.lastname: Halliwell
mesh_terms: D001761:Bleomycin; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn / Q000097:blood*; D007234:Infant, Premature / Q000097:blood*; D007501:Iron / Q000097:blood*
chemical_list: D001761:Bleomycin; D007501:Iron