title: On the rat model of human osteopenias and osteoporoses.
abstract: The idea that rats cannot model human osteopenias errs. The same mechanisms control gains in bone mass (longitudinal bone growth and modeling drifts) and losses (BMU-based remodeling), in young and aged rats and humans. Furthermore, they respond similarly in rats and man to mechanical influences, hormones, drugs and other agents.
authors.affiliation: Department of Orthopaedic Surgery, Southern Colorado Clinic, Pueblo.
authors.forename: H M
authors.initials: HM
authors.lastname: Frost
authors.forename: W S
authors.initials: WS
authors.lastname: Jee
mesh_terms: D000328:Adult; D000818:Animals; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000503:physiopathology; D016723:Bone Remodeling; D002648:Child; D002675:Child, Preschool; D004195:Disease Models, Animal; D006801:Humans; D010024:Osteoporosis / Q000503:physiopathology; D051381:Rats