title: Behavioural consequences following infusion of selective neurokinin agonists into the median raphe nucleus of the rat.
abstract: The locomotor activity induced after infusion of selective neurokinin (NK) agonists into the median raphé nucleus of rats was investigated. In photocell cages, the NK-2-agonist, GR64349, and the NK-3 agonist, senktide, both increased motor activity in a dose-dependent manner. However, the NK-1 agonist, GR73632, had little effect over a range of doses. In the open field, the motor effect of all three NK agonists was identical to that observed in the photocell cages. In addition, senktide induced straub-tail, hind-limb splaying and various oral movements. Such effects were not noted with the other two agonists. These results suggest that activation of NK-2 or NK-3 receptors by the neurokinins, in the median raphe nucleus of the rat, leads to an increase in locomotor activity.
authors.affiliation: Department of Neuropharmacology, Glaxo Group Research Ltd., Ware, Hertfordshire, U.K.
authors.forename: G S
authors.initials: GS
authors.lastname: Mason
authors.forename: P J
authors.initials: PJ
authors.lastname: Elliott
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007267:Injections; D008969:Molecular Sequence Data; D009043:Motor Activity / Q000187:drug effects*; D015288:Neurokinin A / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D011903:Raphe Nuclei; D051381:Rats; D013373:Substance P / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D010446:Peptide Fragments; C054724:senktide; C068031:neurokinin A (3-10), lysyl(3)-glycyl(8)-R-lactam-leucine(9)-; D013373:Substance P; D015288:Neurokinin A