title: Antibiotic-impregnated plaster of Paris beads. Trials with teicoplanin.
abstract: Teicoplanin-impregnated plaster of Paris beads were made and in vitro release properties were studied. Teicoplanin was released in an initial massive dose, with a rapid decline during the first three days, followed by a slowly declining prolonged release up to 30 days. The release tested by diffusion in gelose and high-performance liquid chromatography was found to be 21.4% and 28.2%, respectively, of the amount theoretically present in the beads. Plaster of Paris is a resorbable, nontoxic biomaterial that has already been used to fill dead spaces in bone and deliver antibiotics in the treatment of chronic osteomyelitis. The addition of teicoplanin, a new antistaphylococcal agent with low known bacterial resistance, is a promising alternative. Follow-up tests in vivo, simulating local conditions of the osteomyelitic bone, are necessary to prove efficacy.
authors.affiliation: Institut Calot, Berck-sur-Mer, France.
authors.forename: V
authors.initials: V
authors.lastname: Dacquet
authors.forename: A
authors.initials: A
authors.lastname: Varlet
authors.forename: R N
authors.initials: RN
authors.lastname: Tandogan
authors.forename: M M
authors.initials: MM
authors.lastname: Tahon
authors.forename: L
authors.initials: L
authors.lastname: Fournier
authors.forename: F
authors.initials: F
authors.lastname: Jehl
authors.forename: H
authors.initials: H
authors.lastname: Monteil
authors.forename: G
authors.initials: G
authors.lastname: Bascoulergue
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000032:analysis; D001412:Bacillus subtilis / Q000187:drug effects; D002133:Calcium Sulfate; D002851:Chromatography, High Pressure Liquid; D004337:Drug Carriers; D004353:Drug Evaluation, Preclinical; D006020:Glycopeptides / Q000008:administration & dosage / Q000032:analysis; D008826:Microbial Sensitivity Tests / Q000379:methods; D013211:Staphylococcus aureus / Q000187:drug effects; D013242:Sterilization / Q000379:methods; D017334:Teicoplanin; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D006020:Glycopeptides; D017334:Teicoplanin; D002133:Calcium Sulfate