The role of Wnt genes in vertebrate development.
Over the past decade, many potential candidates for molecules involved in pattern formation in the vertebrate embryo have been identified. Manipulation of the expression of some of these factors has generated fascinating results that have allowed investigators to address their roles in embryogenesis. One such family consists of a group of putative cell signaling molecules related to the proto-oncogene Wnt-1. An accumulating body of evidence suggests that the Wnt-family plays a major role in several aspects of vertebrate development.
Dickinson
M E
ME
Roche Institute of Molecular Biology, Department of Cell and Developmental Biology, Nutley, New Jersey 07110.
McMahon
A P
AP
D000818:Animals; D002490:Central Nervous System / Q000196:embryology; D015870:Gene Expression / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D014714:Vertebrates / Q000196:embryology / Q000235:genetics*; D051153:Wnt Proteins; D051155:Wnt1 Protein; D029961:Zebrafish Proteins
D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; D051155:Wnt1 Protein; D029961:Zebrafish Proteins