title: Bleomycin/cis-platin as neoadjuvant chemotherapy before radical radiotherapy in localized, inoperable carcinoma of the esophagus. A prospective randomized multicentre study: the second Scandinavian trial in esophageal cancer.
abstract: Survival and swallowing function were studied in a randomized trial of 97 patients with inoperable, localized esophageal carcinoma. Radical radiotherapy was given to 51 patients, while 46 patients had two courses of bleomycin/cisplatin before radiotherapy. The survival was 29% after one year, and 6% after 3 years in the radiotherapy group. The survival in the combined treatment group was 18 and 0%, respectively; p = 0.1895. The number of patients who could swallow any food increased from 6% before treatment to 38% after 3 months in the radiotherapy group, and from 0% to 23% in the combined group. No benefit was found by combining bleomycin/cisplatin with radiotherapy.
authors.affiliation: Norwegian Radium Hospital, Oslo.
authors.forename: R
authors.initials: R
authors.lastname: Hatlevoll
authors.forename: S
authors.initials: S
authors.lastname: Hagen
authors.forename: H S
authors.initials: HS
authors.lastname: Hansen
authors.forename: R
authors.initials: R
authors.lastname: Hultborn
authors.forename: A
authors.initials: A
authors.lastname: Jakobsen
authors.forename: M
authors.initials: M
authors.lastname: Mäntylä
authors.forename: H
authors.initials: H
authors.lastname: Modig
authors.forename: E
authors.initials: E
authors.lastname: Munck-Wikland
authors.forename: K
authors.initials: K
authors.lastname: Nygaard
authors.forename: B
authors.initials: B
authors.lastname: Rosengren
mesh_terms: D000368:Aged; D001761:Bleomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003679:Deglutition / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000453:epidemiology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012537:Scandinavian and Nordic Countries / Q000453:epidemiology; D015996:Survival Rate
chemical_list: D001761:Bleomycin; D002945:Cisplatin