title: PEG-bovine hemoglobin: safety in a canine dehydrated hypovolemic-hemorrhagic shock model.
abstract: An initial evaluation of PEG-bHb was performed using a modified hypovolemic shock model. PEG-bHb had a substantially longer intravascular half-life than native Hb and no measurable hemoglobinuria was observed in the canine. PEG-bHb allowed successful resuscitation with an oxygen carrying capacity of 14-22% over that of lactated Ringer's solution.
authors.affiliation: Duke University Medical Center, Dept. of Surgery, Durham, NC 27710.
authors.forename: K
authors.initials: K
authors.lastname: Nho
authors.forename: D
authors.initials: D
authors.lastname: Glower
authors.forename: S
authors.initials: S
authors.lastname: Bredehoeft
authors.forename: H
authors.initials: H
authors.lastname: Shankar
authors.forename: R
authors.initials: R
authors.lastname: Shorr
authors.forename: A
authors.initials: A
authors.lastname: Abuchowski
mesh_terms: D000818:Animals; D001802:Blood Substitutes / Q000302:isolation & purification / Q000627:therapeutic use* / Q000633:toxicity; D003681:Dehydration / Q000628:therapy*; D004195:Disease Models, Animal; D004285:Dogs; D006207:Half-Life; D006454:Hemoglobins / Q000302:isolation & purification / Q000378:metabolism / Q000627:therapeutic use*; D007552:Isotonic Solutions / Q000627:therapeutic use; D011092:Polyethylene Glycols; D012151:Resuscitation; D000077325:Ringer's Lactate; D012449:Safety; D012769:Shock / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D012771:Shock, Hemorrhagic / Q000628:therapy
chemical_list: D001802:Blood Substitutes; D006454:Hemoglobins; D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D011092:Polyethylene Glycols