Regulation of inflammation by lipocortin 1.
The mechanisms that regulate inflammatory responses, and their dysfunction in chronic inflammatory diseases, are poorly understood. Lipocortin 1 is a potential mediator of the anti-inflammatory effects of glucocorticoid hormones. Following the discovery of putative receptors on phagocytes for lipocortin 1, Nick Goulding and Paul Guyre here offer one explanation for the self-limitation of inflammation and the impairment of the mechanism in chronic inflammatory disease.
Goulding
N J
NJ
Bath Institute for Rheumatic Diseases.
Guyre
P M
PM
D000818:Animals; D017302:Annexins; D002135:Calcium-Binding Proteins / Q000276:immunology*; D002908:Chronic Disease; D004195:Disease Models, Animal; D005938:Glucocorticoids / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D009000:Monocytes / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D010586:Phagocytes / Q000276:immunology
D017302:Annexins; D002135:Calcium-Binding Proteins; D005938:Glucocorticoids