title: Life stress and treatment course of recurrent depression: 1. Response during index episode.
abstract: Research on treatment course and outcome in depression is mixed with respect to the implications of life stress. Several concerns are addressed in a prospective study of 91 individuals treated for recurrent depression. Specific forms of stress occurring before treatment entry predicted a poor clinical response both after 16 weeks and after a more extended intervention period. Specific forms of stress occurring during the 1st 6 weeks of treatment also predicted poor response after 16 weeks and after the extended intervention period. Severe stress occurring early in treatment predicted a longer time to attain relief for treatment responders. Concepts underlying the idea that stress-related disorders have a better clinical outcome are discussed, and it is proposed that life stress has different implications for individuals with and without recurrent depression.
authors.affiliation: University of Oregon, Department of Psychology, Eugene 97403-1227.
authors.forename: S M
authors.initials: SM
authors.lastname: Monroe
authors.forename: D J
authors.initials: DJ
authors.lastname: Kupfer
authors.forename: E
authors.initials: E
authors.lastname: Frank
mesh_terms: D000275:Adjustment Disorders / Q000523:psychology / Q000628:therapy*; D000328:Adult; D003131:Combined Modality Therapy; D003866:Depressive Disorder / Q000523:psychology / Q000628:therapy*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use*; D008016:Life Change Events; D008297:Male; D010555:Personality Inventory; D011613:Psychotherapy; D012008:Recurrence
chemical_list: D007099:Imipramine