title: QT-interval abnormalities in hypertrophic cardiomyopathy.
abstract: To examine whether QTc and QTc dispersion across the leads of a surface electrocardiogram (ECG) are different in patients with hypertrophic cardiomyopathy (HCM) compared with normal subjects, we measured QT and calculated QTc in all 12 leads of a surface ECG in 24 patients with HCM and in 20 age- and sex-matched normal control subjects. Maximal QTc was prolonged in HCM patients (465 +/- 24 ms) compared with controls (410 +/- 20 ms) (p < 0.001). QTc dispersion defined as the difference of maximum-minimum QTc was also greater in HCM patients (71 +/- 21 ms) compared with normals (35 +/- 11 ms) (p < 0.001). A correlation was found between the degree of left ventricular hypertrophy expressed by the maximal wall thickness and maximal QTc (r = 0.48, p < 0.02). However, QTc dispersion did not correlate with maximal wall thickness. Thus, patients with HCM show a prolonged QTc (> 440 ms) and increased QTc dispersion compared with normal subjects. In addition, the degree of left ventricular hypertrophy correlates with maximal QTc. The presence of a prolonged QT with increased regional dispersion may be associated with the occurrence of serious ventricular arrhythmia and sudden death in HCM.
authors.affiliation: Department of Medicine, Hammersmith Hospital, Royal Postgraduate Medical School, London, England.
authors.forename: A
authors.initials: A
authors.lastname: Dritsas
authors.forename: E
authors.initials: E
authors.lastname: Sbarouni
authors.forename: D
authors.initials: D
authors.lastname: Gilligan
authors.forename: P
authors.initials: P
authors.lastname: Nihoyannopoulos
authors.forename: C M
authors.initials: CM
authors.lastname: Oakley
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000175:diagnosis* / Q000209:etiology*; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications* / Q000000981:diagnostic imaging; D016757:Death, Sudden, Cardiac / Q000453:epidemiology; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors; D017180:Tachycardia, Ventricular / Q000453:epidemiology