Difference in the concentration of tryptophan metabolites between maternal and umbilical foetal blood.
Maternal and umbilical foetal blood at delivery were analysed for tryptophan metabolites by using fully automated high-performance liquid chromatography. The metabolites detected in 100 microliters of maternal plasma were kynurenine, serotonin, 5-hydroxyindoleacetic acid, indolelactic acid, indoleacetic acid and indolepropionic acid. These metabolites were present in various amounts in the protein-bound form. Except for indolepropionic acid, the concentrations of tryptophan metabolites were significantly higher in umbilical foetal plasma than in maternal plasma. In addition, 3-hydroxyanthranilic acid was present in umbilical foetal blood, but not in maternal blood. Furthermore, kynurenic acid was also detected in amniotic fluids.
Morita
I
I
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Japan.
Kawamoto
M
M
Yoshida
H
H
D000596:Amino Acids / Q000097:blood; D000653:Amniotic Fluid / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005333:Fetus / Q000378:metabolism*; D006801:Humans; D007202:Indicators and Reagents; D007231:Infant, Newborn; D011247:Pregnancy; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D014364:Tryptophan / Q000097:blood*
D000596:Amino Acids; D007202:Indicators and Reagents; D014364:Tryptophan