Conceptual design and cost estimate for a modified hemoglobin production plant.
Polymerized, pyridoxalated stroma-free hemoglobin (Poly PSFH), made from outdated human blood, has excellent attributes for use as a blood substitute. A hypothetical larger scale process for the production of Poly PSFH is detailed, and facility design and cost estimates are presented. This paper gives the opportunity to discuss the engineering activities of process scope definition, utilities selection, and aseptic processing techniques, etc. Compliance with cGMP and other FDA regulation will also be discussed.
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Fluor Daniel Inc., Greenville, SC 29607.
Owings
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D001698:Biomedical Engineering / Q000191:economics / Q000295:instrumentation*; D001709:Biotechnology; D001802:Blood Substitutes / Q000302:isolation & purification*; D003365:Costs and Cost Analysis; D004864:Equipment and Supplies / Q000191:economics; D005160:Facility Design and Construction / Q000191:economics; D006454:Hemoglobins / Q000302:isolation & purification*; D006801:Humans; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives / Q000302:isolation & purification
D001802:Blood Substitutes; D006454:Hemoglobins; C030939:polyhemoglobin-pyridoxal-5-phosphate; D011732:Pyridoxal Phosphate