[Effects of propranolol on the gastroduodenal myoelectrical activity].
The effects of propranolol on the myoelectrical activity of the stomach, pylorus and duodenum were investigated in chronic experiments on rabbits. During the first phase of propranolol action a positive gastro-chronotropic effect was accompanied by a negative cardio-chronotropic effect. The gastro-chronotropic effect was 3 times higher than cardio-chronotropic one. The second phase of the propranolol effect manifested with periodical fluctuation of the gastroduodenal myoelectrical activity during stable bradycardia. Marked reactivity of the gastro-duodenum and periodical fluctuation of its activity are evidence of vital importance of the autoregulation mechanisms for gastroduodenal myoelectric activity.
Shemerovskiĭ
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D000818:Animals; D004386:Duodenum / Q000187:drug effects / Q000502:physiology*; D004576:Electromyography; D005769:Gastrointestinal Motility / Q000187:drug effects; D006339:Heart Rate; D006706:Homeostasis; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D011433:Propranolol / Q000494:pharmacology*; D011708:Pylorus / Q000187:drug effects / Q000502:physiology; D011817:Rabbits; D013270:Stomach / Q000187:drug effects / Q000502:physiology*
D011433:Propranolol