Arterial response to mechanical injury: balloon catheter de-endothelialization.
Coronary angioplasty has been used clinically for over a decade. Its initial promise as an alternative to coronary bypass surgery has only partially been fulfilled because of the high rate of post-operative restenosis. A number of animal models have been devised to study this phenomenon and although none is entirely satisfactory, they have, together with recent advances in molecular biology provided an insight into the cellular mechanisms that may contribute to this complication. This knowledge may ultimately lead to a means of therapeutic intervention. This review summarises our present understanding of the pathology of post-angioplasty re-stenosis as revealed by studies using the balloon catheter de-endothelialization model, and discusses some of the intervention strategies that have been attempted.
Ferns
G A
GA
William Harvey Research Institute, St. Bartholomew's Hospital Medical College University of London, U.K.
Stewart-Lee
A L
AL
Anggård
E E
EE
D000800:Angioplasty, Balloon / Q000009:adverse effects*; D000818:Animals; D001158:Arteries / Q000187:drug effects / Q000293:injuries* / Q000378:metabolism; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000187:drug effects / Q000293:injuries* / Q000378:metabolism; D006801:Humans; D013045:Species Specificity