title: Oxidative and other DNA damages as the basis of aging: a review.
abstract: DNA damages occur continuously in cells of living organisms. While most of these damages are repaired, some accumulate. In particular, there is evidence for DNA damage accumulation in non-dividing cells of mammals. These accumulated DNA damages probably interfere with RNA transcription. We consider that the decline in the ability of DNA to serve as a template for gene expression is the primary cause of aging. Oxidative DNA damages are among the best documented and prevalent DNA damages and are likely to be a prominent cause of aging.
authors.affiliation: Department of Microbiology, College of Medicine, Howard University, Washington, DC 20059.
authors.forename: G E
authors.initials: GE
authors.lastname: Holmes
authors.forename: C
authors.initials: C
authors.lastname: Bernstein
authors.forename: H
authors.initials: H
authors.lastname: Bernstein
mesh_terms: D000375:Aging / Q000235:genetics*; D000818:Animals; D002455:Cell Division; D004247:DNA / Q000235:genetics* / Q000378:metabolism; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D008017:Life Expectancy
chemical_list: D004247:DNA