[Preventive and therapeutic effects of hirudo on incipient acute tubular necrosis in rats].
Male Sprague-Dawley rats, weighing 180-250 g and depleted with water for 16 h, were injected with glycerol (im) to induce acute tubular necrosis, and then divided into groups given blood-activating and stasis-removing drug, Hirudo solution (GH) tap water (GW), verapamil (GV) and none (GSDW) in incipient stage separately. It was observed that levels of BUN increased at 24th and 48th h after administration of glycerol and levels of Bcr increased at 3rd, 24th and 48th h after injecting glycerol in GH were significantly lower than those increased in GW and GSDW (P less than 0.05-P less than 0.001), but roughly similar to those in GV (P greater than 0.05-P greater than 0.5). Renal histopathological damage under light microscope and electron-microscope in GH at 3rd and 24th h after administration of glycerol were also less severe than those in GW and GSDW. The results suggested that Hirudo could exert a preventive and therapeutic effects on incipient acute tubular necrosis induced by glycerol in rats.
Shi
J C
JC
Hebei Academy of Medical Sciences, Shijiazhuang.
D058186:Acute Kidney Injury / Q000517:prevention & control*; D000818:Animals; D001806:Blood Urea Nitrogen; D005990:Glycerol; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced / Q000188:drug therapy*; D007865:Leeches; D008297:Male; D008419:Materia Medica / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D014700:Verapamil
D008419:Materia Medica; D014700:Verapamil; D005990:Glycerol