title: Patent infections of Ascaris suum in pigs: effect of previous exposure to multiple, high doses of eggs and various treatment regimes.
abstract: Fifty-four crossbred, 4-week-old pigs divided into nine equal groups were used to test whether multiple inoculations with high numbers of A. suum eggs with or without anthelmintic would result in patent infections. All pigs exposed to multiple prechallenge inoculations of 500, 1000, 2000, 5000, 10,000 and 20,000 and challenged orally 2 weeks later with 10,000 eggs harboured adult worms. When prechallenge infections were removed by pyrantel tartrate treatment the animals were more susceptible to challenge than controls not previously exposed to infections. The same drug used from 2 days before until 10 days after the last prechallenge infection eliminated that effect. Pigs subjected to the same multiple egg dosing regimen but given feed containing fenbendazole immediately before, during and for 10 days after multiple dosing developed significantly more adult intestinal worms after challenge than any other group. These worms were, however, significantly shorter than those that developed in any group of pigs. Adult worms from all these groups produced eggs that after embryonation were infective to mice.
authors.affiliation: Wallaceville Animal Research Centre, Ministry of Agriculture & Fisheries, Upper Hutt, New Zealand.
authors.forename: M
authors.initials: M
authors.lastname: Stankiewicz
authors.forename: W
authors.initials: W
authors.lastname: Jonas
authors.forename: D L
authors.initials: DL
authors.lastname: Froe
mesh_terms: D000818:Animals; D001196:Ascariasis / Q000188:drug therapy / Q000276:immunology / Q000662:veterinary*; D017165:Ascaris suum / Q000276:immunology*; D004198:Disease Susceptibility; D005260:Female; D005273:Fenbendazole / Q000627:therapeutic use; D011717:Pyrantel Tartrate / Q000627:therapeutic use; D011897:Random Allocation; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy / Q000276:immunology*
chemical_list: D005273:Fenbendazole; D011717:Pyrantel Tartrate