A cDNA clone encoding the ADP/ATP translocase of Drosophila melanogaster shows a high degree of similarity with the mammalian ADP/ATP translocases.
A complementary DNA clone encoding the ADP/ATP translocase in Drosophila melanogaster has been identified. It has been shown by sequence analysis to contain a single open reading frame that encodes a polypeptide 297 amino acids long. This polypeptide shows extensive similarities to the known eukaryotic translocase polypeptides, the similarity being greatest (up to 80% identity) to the mammalian ADP/ATP translocases. In situ hybridization to polytene chromosomes of D. melanogaster with the sequence characterized in this study showed localization at a single site on the X chromosome at 9E. DNA transfer hybridization experiments suggest that more than one gene coding for the ADP/ATP translocase is present in the D. melanogaster genome.
Louvi
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Department of Biochemistry, Cell and Molecular Biology and Genetics, University of Athens, Panepistimiopolis, Greece.
Tsitilou
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SG
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle / Q000235:genetics; D004247:DNA / Q000235:genetics; D004331:Drosophila melanogaster / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D008322:Mammals / Q000235:genetics* / Q000378:metabolism; D000226:Mitochondrial ADP, ATP Translocases / Q000235:genetics*; D008969:Molecular Sequence Data; D009492:Neurospora crassa / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics; D016415:Sequence Alignment; D013045:Species Specificity; D003313:Zea mays / Q000235:genetics
D004247:DNA; D000226:Mitochondrial ADP, ATP Translocases