title: BCG therapy in superficial bladder tumours--complications and precautions.
abstract: Bacillus Calmette-Guérin (BCG) immunotherapy represents a valuable treatment in the management of superficial bladder cancer, but the therapy is not without its risks. A total of 220 patients have been included in a review of local and systemic side effects associated with BCG immunotherapy. The majority of side effects are mild and self limiting, but potentially life threatening complications can arise with BCG immunotherapy. These systemic side effects include pneumonitis/hepatitis and systemic BCG infection. Recommendations are given for the use and administration of BCG, and if these rules are correctly applied, BCG may be administered safely, and with confidence.
authors.affiliation: Service d'Urologie, Groupe Hospitalier Cochin, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Steg
authors.forename: S
authors.initials: S
authors.lastname: Adjiman
authors.forename: B
authors.initials: B
authors.lastname: Debré
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000995:Antitubercular Agents / Q000627:therapeutic use*; D001500:BCG Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D002295:Carcinoma, Transitional Cell / Q000628:therapy*; D003556:Cystitis / Q000188:drug therapy / Q000209:etiology*; D005334:Fever / Q000188:drug therapy / Q000209:etiology; D006505:Hepatitis / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D008875:Middle Aged; D009164:Mycobacterium Infections / Q000209:etiology*; D009163:Mycobacterium bovis / Q000472:pathogenicity; D011014:Pneumonia / Q000188:drug therapy / Q000209:etiology*; D013256:Steroids; D001749:Urinary Bladder Neoplasms / Q000628:therapy*; D014774:Virulence
chemical_list: D000893:Anti-Inflammatory Agents; D000995:Antitubercular Agents; D001500:BCG Vaccine; D013256:Steroids