[The keratinocyte].
This review summarizes recent data on the keratinocyte, the major cell type in the epidermis. A two-state model is proposed: in the "resting" state, the keratinocyte is committed to a program of terminal differentiation focusing on production of an efficient barrier, the stratum corneum, and of the epidermal basement membrane; the activated state, first discovered in cell culture studies, occurs in vivo during epidermal wound healing and inflammatory skin diseases.
Taïeb
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Laboratoire d'Immunologie/CNRS URA 1456, Université de Bordeaux II, France.
D002454:Cell Differentiation / Q000502:physiology; D000078404:Epidermal Cells; D004817:Epidermis / Q000502:physiology*; D000091344:Filaggrin Proteins; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology; D007381:Intermediate Filament Proteins / Q000502:physiology; D015603:Keratinocytes / Q000166:cytology / Q000502:physiology* / Q000648:ultrastructure; D007633:Keratins / Q000737:chemistry / Q000502:physiology; D011498:Protein Precursors / Q000502:physiology; D012871:Skin Diseases / Q000235:genetics / Q000378:metabolism; D011503:Transglutaminases / Q000502:physiology; D014945:Wound Healing / Q000502:physiology
D000091344:Filaggrin Proteins; D007375:Interleukin-1; D007381:Intermediate Filament Proteins; D011498:Protein Precursors; C032253:involucrin; D007633:Keratins; D011503:Transglutaminases