[Immunologic disorders in patients with idiopathic subretinal neovascular membrane].
The authors analyze the results of comprehensive clinical and immunologic examinations of 52 patients with this condition (SNVM) in its active and inactive phases, angiographically confirmed, aged 19 to 46; 32 of these were women (61.5%), 20 (38.4%) men. A complex of immunologic methods was employed to reveal the etiology of the condition and the immune status of SNMV patients. The origin of the condition was identified in 44.2% of patients; it was toxoplasmic in 19.2, autoimmune in 15.4, tuberculous in 7.7, and mixed toxoplasmic and tuberculous in 1.9% of cases. T lymphocyte functional activity was inhibited in 37.5% of patients with the exudative hemorrhagic phase of SNMV and in 16.7% of those in the cicatrization phase. Changes in the humoral immunity presenting as gammapathies were detected in 34% of patients, those manifesting by hyperconcentrations of circulating immune complexes in 66.7%, and of cryoglobulins in 37.8% of patients. Krypton laser coagulation was employed in multiple-modality treatment of patients with SNMV. The remissions persisted for 3-5 years.
Teplinskaia
L E
LE
Kaliberdina
A F
AF
Katsnel'son
L A
LA
Zaĭtseva
N S
NS
D000328:Adult; D000936:Antigen-Antibody Complex / Q000032:analysis; D005123:Eye / Q000098:blood supply*; D005260:Female; D006801:Humans; D007154:Immune System Diseases / Q000150:complications* / Q000175:diagnosis; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000209:etiology* / Q000276:immunology / Q000601:surgery; D013601:T-Lymphocytes / Q000276:immunology
D000936:Antigen-Antibody Complex