[Prevention of liver metastasis by intrasplenic injection of OK-432].
The effects of OK-432 on artificial liver metastasis of tumor-bearing mice were assessed using murine colon adenocarcinoma MCA-38 in C57 BL/6 mice. OK-432 injection into the spleen reduced the liver metastases. In gastro-intestinal cancer patients, the effects of OK-432 injection into the spleen were assessed with functional T cell subsets. The treatment resulted in an increase in the number of cytotoxic T cells, but a decrease in the suppressor T cells. The facts suggested that OK-432 injection into the spleen had an ability to prevent liver metastases.
Ohmori
K
K
Second Dept. of Surgery, Kyoto Prefectural University of Medicine.
Yamagishi
H
H
Oka
T
T
D000230:Adenocarcinoma / Q000276:immunology / Q000556:secondary*; D000818:Animals; D003110:Colonic Neoplasms / Q000276:immunology / Q000473:pathology*; D007267:Injections; D007958:Leukocyte Count; D008113:Liver Neoplasms / Q000517:prevention & control* / Q000556:secondary*; D016131:Lymphocyte Subsets; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010844:Picibanil / Q000627:therapeutic use*; D015375:Receptors, Interleukin-2 / Q000032:analysis; D013154:Spleen; D050378:T-Lymphocytes, Regulatory
D015375:Receptors, Interleukin-2; D010844:Picibanil