Impairment of cerebral biogenic amine synthesis in a patient receiving high-dose methotrexate.
A transient acute neurologic syndrome occurred in a 15-year-old boy receiving high-dose methotrexate (MTX) for acute lymphoblastic leukemia. Cerebrospinal fluid analysis revealed a decrease of homovanillic acid and 5-hydroxyindoleacetic acid concentrations with a rise of biopterin levels. These findings suggest that MTX can induce a transient alteration of the metabolism of tetrahydrobiopterin leading to the defect of biogenic amine neurotransmitter synthesis.
Millot
F
F
Service d'Hématologie clinique, Centre Hospitalier, France.
Dhondt
J L
JL
Hayte
J M
JM
Bauters
F
F
D000293:Adolescent; D001679:Biogenic Amines / Q000096:biosynthesis*; D001708:Biopterins / Q000134:cerebrospinal fluid; D001921:Brain / Q000378:metabolism*; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008727:Methotrexate / Q000008:administration & dosage*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000134:cerebrospinal fluid / Q000188:drug therapy*
D001679:Biogenic Amines; D001708:Biopterins; D006897:Hydroxyindoleacetic Acid; D006719:Homovanillic Acid; D008727:Methotrexate