The coagulative system in haemodialyzed patients: the relationship between the elderly and hypertrygliceridaemia.
The coagulative system has an important role on haemodialysis and on atherosclerosis genesis; in particular the platelets are key elements of the coagulation and of atherosclerosis phenomena. Alterations of the coagulative system and increase risk of developing atherosclerosis are reported in the aging. We in this paper, report the results obtained studying the influence of the interaction between the elderly and dyslipidemia on the coagulative system in haemodialyzed patients. The obtained data showed that the hypertriglyceridaemia in interaction with the elderly accelerates and increases platelet aggregation after stimulation by ADP, Epinephrine and Collagen. So, it is important to consider hypertriglyceridaemia and age as thrombogenic factors and atherosclerosis accelerating factors in haemodialyzed patients.
Savica
V
V
Chair of Nephrology, University of Messina.
Bellinghieri
G
G
Barbera
C M
CM
Egitto
M
M
Consolo
F
F
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000367:Age Factors; D000368:Aged; D001161:Arteriosclerosis / Q000209:etiology; D001778:Blood Coagulation Disorders / Q000209:etiology*; D003094:Collagen / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005344:Fibrinopeptide A / Q000032:analysis; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications*; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D006435:Renal Dialysis / Q000009:adverse effects*; D013917:Thrombin / Q000494:pharmacology; D014511:Uremia / Q000097:blood* / Q000150:complications / Q000628:therapy; D001620:beta-Thromboglobulin / Q000032:analysis
D001620:beta-Thromboglobulin; D005344:Fibrinopeptide A; D000244:Adenosine Diphosphate; D003094:Collagen; D013917:Thrombin; D004837:Epinephrine