title: Characteristic findings on the standard 12-lead ECG in patients with the fasciculoventricular Mahaim fiber.
abstract: Standard 12-lead electrocardiograms with a Q wave in lead V1 were obtained from 32 subjects without organic cardiac disease and analyzed for features that might characterize an abnormal atrioventricular conduction through the fasciculoventricular Mahaim fiber. Following an infusion of ajmaline, the Q wave in V1 vanished abruptly and changed to an rS pattern in the 12 ajmaline responders. Discriminant analysis was performed to distinguish the ajmaline responders from the others. The explanatory variables were number of precordial leads with the abnormal Q wave, existence of the septal q waves, existence of the slurring of the Q wave in V1, existence of clockwise rotation, and existence of high voltage (RV5 + SV1 > 3.5 mV). Three variables, the absence of the septal q waves, the presence of the slurring, and the absence of clockwise rotation, were found to predict a positive response to ajmaline (discriminant probability = 77%). These findings associated with the Q wave in V1 suggest that the fasciculoventricular fiber may be present.
authors.affiliation: First Department of Internal Medicine, Nagoya University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Miyaguchi
authors.forename: J
authors.initials: J
authors.lastname: Tsuzuki
authors.forename: M
authors.initials: M
authors.lastname: Yokota
authors.forename: H
authors.initials: H
authors.lastname: Hayashi
mesh_terms: D000293:Adolescent; D000328:Adult; D000404:Ajmaline / Q000494:pharmacology; D004562:Electrocardiography / Q000187:drug effects; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011227:Pre-Excitation, Mahaim-Type / Q000503:physiopathology*
chemical_list: D000404:Ajmaline