Modulation of the behavioural effects of interleukin-1 in mice by nitric oxide.
Interleukin-1 is a cytokine which mediates the host response to infection and inflammation and is responsible for sickness behaviour. Inhibition of nitric oxide synthase activity by N omega nitro-L-Arginine-Methyl-ester (30 mg kg-1, i.p.) potentiated the depressive effects of interleukin-1 (375 ng, i.p.) on social investigation in mice. This effect was attenuated by L-arginine (180 mg kg-1, i.p.) but not by D-arginine. The same treatment did not alter the body weight loss induced by interleukin-1. These results suggest that nitric oxide plays a protective role in the neural effects of interleukin-1.
Bluthé
R M
RM
INRA-INSERM U176, Bordeaux, France.
Sparber
S
S
Dantzer
R
R
D000594:Amino Acid Oxidoreductases / Q000037:antagonists & inhibitors*; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D007375:Interleukin-1 / Q000502:physiology*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D019331:NG-Nitroarginine Methyl Ester; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase; D012919:Social Behavior
D007375:Interleukin-1; D009569:Nitric Oxide; D001120:Arginine; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases; D019331:NG-Nitroarginine Methyl Ester