title: Selective localization of radioiodinated alkylphosphocholine derivatives in tumors.
abstract: We have designed and synthesized two radioiodinated analogs of hexadecylphosphocholine in order to evaluate their tumor imaging potential. 12-(m[125I]iodophenyl)dodecyl phosphocholine (NM-324) and hexadecyl-2-[N,N-dimethyl-N-(m[125I]iodobenzyl)-ammonium] ethyl phosphate (NM-326) demonstrated the ability of such compounds to localize in and thereby visualize the Walker 256 tumor in rats. However, the tumor avidity of NM-324 was far superior to NM-326. In addition, NM-324 showed excellent tumor localization in athymic mice bearing subcutaneous human tumors.
authors.affiliation: Department of Pharmacology, University of Michigan, Ann Arbor 48109.
authors.forename: K P
authors.initials: KP
authors.lastname: Plotzke
authors.forename: T
authors.initials: T
authors.lastname: Haradahira
authors.forename: L
authors.initials: L
authors.lastname: Stancato
authors.forename: N M
authors.initials: NM
authors.lastname: Olken
authors.forename: S
authors.initials: S
authors.lastname: Skinner
authors.forename: M D
authors.initials: MD
authors.lastname: Gross
authors.forename: R L
authors.initials: RL
authors.lastname: Wahl
authors.forename: R E
authors.initials: RE
authors.lastname: Counsell
mesh_terms: D000818:Animals; D002279:Carcinoma 256, Walker / Q000000981:diagnostic imaging*; D005260:Female; D007457:Iodine Radioisotopes; D008099:Liver / Q000378:metabolism; D010742:Phospholipid Ethers / Q000138:chemical synthesis / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
chemical_list: D007457:Iodine Radioisotopes; D010742:Phospholipid Ethers; C077316:NM 326; C077315:NM 324