Study of effect of the newly developed artificial blood "Neo Red Cells (NRC)" on hemodynamics and blood gas transport in canine hemorrhagic shock.
The purpose of this study is to evaluate the newly developed liposome-encapsulated hemoglobin, named Neo Red Cells (NRC), in the treatment of hemorrhagic shock. The particle size of NRC is 180 +/- 88 nm, the hemoglobin concentration is 5.6 g/dl, the viscosity is 2 cp and P50 is 49.5 mmHg. The experiment was carried out on six mongrel dogs suffering hemorrhagic shock. Blood was extracted from the femoral artery and blood pressure became lower than 60 mmHg. NRC in amount equal to the amount of blood extracted was transfused immediately. Inhalating normal room air, the above manipulation was repeated 3-5 times. After 59% to 88% blood exchange using NRC, the total peripheral vascular resistance index (TPRI) was reduced and the cardiac index (CI) was increased, thereby alleviating the burden on the heart. The reduction of TPRI in the presence of hemorrhagic shock is presumed to be due to the small size of the NRC granules and their low viscosity. As the exchange rate increased, the oxygen consumption (VO2) increased remarkably, presumably due to the increase of CI and A-V difference of oxygen content. The conclusion of the study is that NRC is more suitable than natural blood for the treatment of hemorrhagic shock.
Usuba
A
A
Department of Surgery I, Fukushima Medical College, Hikarigaoka Fukushima City, Japan.
Motoki
R
R
Suzuki
K
K
Sakaguchi
K
K
Takahashi
A
A
D000818:Animals; D001693:Biological Transport, Active; D001802:Blood Substitutes / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004285:Dogs; D006439:Hemodynamics; D006454:Hemoglobins / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D006801:Humans; D008081:Liposomes; D010100:Oxygen / Q000097:blood; D012771:Shock, Hemorrhagic / Q000097:blood / Q000503:physiopathology / Q000628:therapy*
D001802:Blood Substitutes; D006454:Hemoglobins; D008081:Liposomes; C016484:hemoglobin, stroma free; D010100:Oxygen