Rare point mutation at codon 301 and 969 of FMS/M-CSF receptor in acute myelomonocytic and monocytic leukemia.
We have investigated whether point mutations occurred at codon 301 or 969 of FMS (M-CSF receptor) in 19 patients with acute myelomonocytic (M4) and monocytic leukemia (M5). Nineteen peripheral blood and bone marrow blood samples collected from M4 and M5 patients were examined by using polymerase chain reaction and hybridization to allele specific oligonucleotide probes. Mutations at codon 301 and 969 of FMS were not detected in any samples. FMS gene mutations at codon 301 and 969 were rarely involved in M4 and M5 patients in Japan.
Natazuka
T
T
Department of Medicine, Kobe University School of Medicine, Japan.
Matsui
T
T
Ito
M
M
Nakata
H
H
Nakagawa
T
T
Nakamura
H
H
Masaoka
T
T
Isobe
T
T
Nakao
Y
Y
D000595:Amino Acid Sequence; D003062:Codon / Q000235:genetics*; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000235:genetics*; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics*; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics*; D016133:Polymerase Chain Reaction; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000235:genetics*
D003062:Codon; D016186:Receptor, Macrophage Colony-Stimulating Factor