title: Implantation of p(HEMA)-collagen composite into bone.
abstract: The replacement of bone defects is very important in clinical practice. This study compares biological properties of poly(2-hydroxyethyl methacrylate)-collagen composite with those exhibited by pure p(HEMA), an insoluble fraction of calf skin collagen (ISC-40) and demineralized bone matrix after implantation into pig or dog femurs. The levels of biodegradation or destruction of implants and healing of bone defects were studied using X-ray photography, histology and enzyme histochemistry. The results indicated a significant effect of collagen on biological destruction of the p(HEMA)-composite implants; even a minute amount of collagen influences this process dramatically. A stimulatory action of collagen on new bone formation may be of importance in bone defect healing.
authors.affiliation: Department of Anatomy, Faculty of Medicine I, Charles University, Prague, Czechoslovakia.
authors.forename: K
authors.initials: K
authors.lastname: Smetana
authors.forename: M
authors.initials: M
authors.lastname: Stol
authors.forename: P
authors.initials: P
authors.lastname: Korbelár
authors.forename: M
authors.initials: M
authors.lastname: Novák
authors.forename: M
authors.initials: M
authors.lastname: Adam
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001842:Bone and Bones / Q000187:drug effects* / Q000648:ultrastructure; D002417:Cattle; D003094:Collagen / Q000648:ultrastructure; D004285:Dogs; D006801:Humans; D011102:Polyhydroxyethyl Methacrylate; D019736:Prostheses and Implants; D011475:Prosthesis Failure; D013552:Swine; D013556:Swine, Miniature
chemical_list: D001672:Biocompatible Materials; D011102:Polyhydroxyethyl Methacrylate; D003094:Collagen