title: Formaldehyde, glyoxal, urethane, methyl carbamate, 2,3-butanedione, 2,3-hexanedione, ethyl acrylate, dibromoacetonitrile and 2-hydroxypropionitrile induce chromosome loss in Saccharomyces cerevisiae.
abstract: Induction of mitotic chromosome loss could be demonstrated for the dialdehyde glyoxal, the diketones 2,3-butanedione and 2,3-hexanedione, ethyl and methyl carbamate, ethyl acrylate, dibromoacetonitrile, 2-hydroxypropionitrile and formaldehyde, but only when they were combined with subacute concentrations of propionitrile, which is a strong inducer of chromosomal malsegregation. The same chemicals did not induce mitotic chromosome loss when applied in pure form. However, glyoxal, ethyl acrylate, dibromoacetonitrile and formaldehyde when applied in pure form also induced mitotic recombination. Respiratory deficiency was induced, in the absence of propionitrile, by these recombinogenic agents and also by 2,3-hexanedione and 2-hydroxypropionitrile which are not recombinogenic.
authors.affiliation: Institut für Mikrobiologie, Technische Hochschule, Darmstadt, Germany.
authors.forename: F K
authors.initials: FK
authors.lastname: Zimmermann
authors.forename: A
authors.initials: A
authors.lastname: Mohr
mesh_terms: D000097:Acetonitriles / Q000633:toxicity; D000179:Acrylates / Q000633:toxicity; D002219:Carbamates / Q000633:toxicity; D002872:Chromosome Deletion; D003931:Diacetyl / Q000633:toxicity; D005557:Formaldehyde / Q000633:toxicity; D005821:Genetic Techniques; D006037:Glyoxal / Q000633:toxicity; D006588:Hexanones / Q000633:toxicity; D009152:Mutagenicity Tests / Q000379:methods*; D009153:Mutagens / Q000633:toxicity*; D009570:Nitriles / Q000633:toxicity; D010101:Oxygen Consumption / Q000187:drug effects; D011995:Recombination, Genetic / Q000187:drug effects*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics*; D014520:Urethane / Q000633:toxicity
chemical_list: D000097:Acetonitriles; D000179:Acrylates; D002219:Carbamates; D006588:Hexanones; D009153:Mutagens; D009570:Nitriles; D005557:Formaldehyde; D014520:Urethane; D006037:Glyoxal; C043231:2,3-hexanedione; C040833:ethyl acrylate; C036868:methyl carbamate; C005557:propionitrile; D003931:Diacetyl; C051715:dibromoacetonitrile