Left ventricular hypertrophy and diastolic dysfunction.
The hypertrophied heart generally preserves systolic function, but it pays a price in diastolic dysfunction. Coronary reserve is impaired and susceptibility to myocardial ischemia increased. The pathophysiology is managed by addressing causes of pressure overload, preventing tachycardia, or, of course, by specific strategies to reduce or eliminate ischemia.
Lorell
B H
BH
Harvard Medical School, Boston.
D000222:Adaptation, Physiological; D000818:Animals; D003326:Coronary Circulation / Q000502:physiology; D003971:Diastole / Q000502:physiology*; D006321:Heart / Q000503:physiopathology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D017202:Myocardial Ischemia / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D013610:Tachycardia / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D016277:Ventricular Function, Left / Q000502:physiology