[Induction of differentiation of human leukemia cells].
Human myeloid leukemia cells do not differentiate into functional end-cells but remain in the proliferation pool. Human cell lines can serve as model for hematopoietic cells arrested at different stages of myeloid differentiation and helps to dissect the cellular and molecular events involved in leukemogenesis. Furthermore, several agents have been identified as inducers of differentiation of leukemia cells. Exciting new clinical observation have shown that patients with APL respond well to the treatment with all-trans retinoic acid. RAR-alpha gene was proved to translocated from chromosome 17 to a locus PML on chromosome 15. This new chimeric gene, PML-RAR alpha is extremely important to understand the leukemogenesis of APL.
Kizaki
M
M
Division of Hematology, Keio University School of Medicine, Tokyo, Japan.
Nakajima
H
H
Ikeda
Y
Y
D002117:Calcitriol / Q000494:pharmacology / Q000627:therapeutic use; D002352:Carrier Proteins / Q000235:genetics; D002454:Cell Differentiation / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D002678:Chimera; D016207:Cytokines / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007372:Interferons / Q000494:pharmacology / Q000627:therapeutic use; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D018168:Receptors, Retinoic Acid; D014212:Tretinoin / Q000494:pharmacology* / Q000627:therapeutic use; D014407:Tumor Cells, Cultured
D002352:Carrier Proteins; D016207:Cytokines; D018168:Receptors, Retinoic Acid; D014212:Tretinoin; D007372:Interferons; D002117:Calcitriol