T-cell and B-cell function in lupus.
B-cell hyperactivity is characteristic of lupus and appears to be, in many instances, T-cell driven. Recent work continues to examine the paradox of T-cell activation in vivo and depressed T-cell function in vitro. The role of intrinsic B-cell abnormalities, particularly in CD5+ B cells, is an area of active investigation.
Via
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CS
University of Maryland School of Medicine, Baltimore.
Handwerger
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BS
D000818:Animals; D015703:Antigens, CD; D001402:B-Lymphocytes / Q000276:immunology*; D018956:CD5 Antigens; D016207:Cytokines / Q000096:biosynthesis; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D051379:Mice; D010641:Phenotype; D011948:Receptors, Antigen, T-Cell; D013601:T-Lymphocytes / Q000276:immunology*
D015703:Antigens, CD; D018956:CD5 Antigens; D016207:Cytokines; D011948:Receptors, Antigen, T-Cell