title: Penetration of lomefloxacin into human prostatic tissue.
abstract: Serum and prostatic tissue concentrations of lomefloxacin were measured in 12 elderly patients who underwent transurethral resection of the prostate after receiving a single oral dose of 400 mg. The peak serum concentration of lomefloxacin was 2.5-10.0 micrograms/mL (mean, 5.2 +/- 1.9 micrograms/mL). During surgery, serum and tissue concentrations averaged 4.6 +/- 2.2 micrograms/mL and 6.5 +/- 2.7 micrograms/g, respectively. The ratio of tissue to serum concentrations was 1.53 +/- 0.54. The levels of lomefloxacin in serum and prostatic tissue were found to be higher than the minimum inhibitory concentration (MIC) values for most urinary tract pathogens.
authors.affiliation: Department of Biochemistry, Rouen University School of Medicine, France.
authors.forename: A
authors.initials: A
authors.lastname: Leroy
authors.forename: G
authors.initials: G
authors.lastname: Humbert
authors.forename: J P
authors.initials: JP
authors.lastname: Fillastre
authors.forename: P
authors.initials: P
authors.lastname: Grise
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D024841:Fluoroquinolones; D006801:Humans; D008297:Male; D008875:Middle Aged; D011292:Premedication; D011467:Prostate / Q000378:metabolism*; D011468:Prostatectomy; D011470:Prostatic Hyperplasia / Q000378:metabolism / Q000601:surgery; D015363:Quinolones / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C053091:lomefloxacin