Synthesis and characterization of artificial red cell (ARC).
An unsaturated lipid made from 2,4-octadecadienoic acid was used as a component of phospholipid vesicles. The vesicles (0.2 micron phi) was prepared by an extrusion method, and the unsaturated lipid was polymerized with gamma-ray. Vesicles constructed from the polylipid show enormous stability during long term storage in frozen state and can be handled easily. Negative effect could not be confirmed in vitro tests. This system satisfies all the physiological conditions, such as oxygen transport ability and solution properties as a blood substitute.
Tsuchida
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Department of Polymer Chemistry, Waseda University, Tokyo, Japan.
D000818:Animals; D001802:Blood Substitutes / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D004285:Dogs; D004355:Drug Stability; D006454:Hemoglobins / Q000737:chemistry; D008051:Lipid Bilayers / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D010100:Oxygen; D010743:Phospholipids / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives / Q000737:chemistry; D051381:Rats; D012996:Solutions
D001802:Blood Substitutes; D006454:Hemoglobins; D008051:Lipid Bilayers; D010743:Phospholipids; D011108:Polymers; D012996:Solutions; C030939:polyhemoglobin-pyridoxal-5-phosphate; D011732:Pyridoxal Phosphate; D010100:Oxygen