Structural basis of the in vivo induction of micronuclei.
The structural basis of the in vivo induction of micronuclei was examined with CASE, a structure-activity relational method. The CASE program identified a number of structures associated with this activity. When used to predict the activity of chemicals not included in the learning set, these structural determinants gave a concordance in excess of 83%. The existence of a structural basis for the induction of micronuclei will permit an investigation of the mechanistic basis of this phenomenon.
Yang
W L
WL
Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, PA 15261.
Klopman
G
G
Rosenkranz
H S
HS
D016208:Databases, Factual; D015162:Micronucleus Tests; D009153:Mutagens / Q000737:chemistry* / Q000633:toxicity; D013329:Structure-Activity Relationship
D009153:Mutagens