[Immunohistochemical detection of glutathione S-transferase (GST) -pi in head and neck carcinoma and its changes by radiotherapy].
It is well known that the "placental form of glutathione S-transferase" (GST-pi) is present in high concentrations in most human carcinomas. However, its expression in head and neck carcinomas have not yet been reported. The author investigated the expression of GST-pi in the tissue of pharyngeal and laryngeal carcinomas by the immunohistochemical procedure, and the following results were obtained: 1) GST-pi was positive in 80% of laryngeal carcinomas (35 cases) and 52.8% of pharyngeal carcinomas (36 cases). As a rule, well differentiated squamous cell carcinomas showed stronger expression of GST-pi than poorly differentiated squamous cell carcinomas. 2) Although normal epithelia of the pharynx and larynx showed negative GST-pi, it should be noticed that 54.6% of precancerous epithelia (11 cases) showed positive GST-pi. 3) Most patients treated with radiotherapy showed the diminution of GST-pi expression after the irradiation. However, co-relation between the strength of initial GST-pi expression and the effectiveness of radiotherapy was not observed (p < 0.01).
Tanita
J
J
Department of Otolaryngology, Hirosaki University School of Medicine.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000473:pathology / Q000532:radiotherapy; D005260:Female; D005982:Glutathione Transferase / Q000378:metabolism* / Q000528:radiation effects; D006258:Head and Neck Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000532:radiotherapy; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged
D014408:Biomarkers, Tumor; D005982:Glutathione Transferase