Combined liver kidney transplantation in primary hyperoxaluria type I. Prevention of the recidive of calcium oxalate deposits in the renal graft.
We report the case of a 31-year-old patient who underwent combined liver and kidney transplantation for primary hyperoxaluria type I. Intensive hemodialysis was performed before the intervention and post-operatively in order to maintain plasma oxalate levels near the normal range. In spite of the correction of the liver enzyme deficiency, oxalate removal from the tissular stores led to prolonged hyperoxaluria, more longer than one year after the transplantation, as already reported. This increased urinary oxalate excretion exposes the renal graft to the risk of recurrence of calcium oxalate deposits and stone formation during a prolonged period. Hemodialysis in the postoperative period and fluid intake allowing a large urine volume might be able to decrease the concentration of urinary oxalate under the critical value of 300 mumol/l, at which supersaturation of urine in respect of calcium oxalate occurs.
Lloveras
J J
JJ
Service de Néphrologie, CHU Toulouse Rangueil, France.
Durand
D
D
Dupre
C
C
Rischman
P
P
Fourtanier
G
G
Ton That
H
H
Suc
J M
JM
D000328:Adult; D002129:Calcium Oxalate / Q000378:metabolism* / Q000652:urine; D005260:Female; D005440:Fluid Therapy; D005665:Furosemide / Q000627:therapeutic use; D006801:Humans; D006960:Hyperoxaluria, Primary / Q000453:epidemiology / Q000517:prevention & control / Q000601:surgery*; D007668:Kidney / Q000378:metabolism*; D016030:Kidney Transplantation; D016031:Liver Transplantation; D012008:Recurrence; D006435:Renal Dialysis; D012307:Risk Factors; D013997:Time Factors
D002129:Calcium Oxalate; D005665:Furosemide