CD5+ B lymphocytes and T-cell subsets in a case of juvenile rheumatoid arthritis.
Recent research has demonstrated that CD5+ B lymphocytes have an important role in autoimmune and rheumatic diseases. In a case of juvenile rheumatoid arthritis (JRA), we observed the behavior of these cells and other subpopulations of T lymphocytes of peripheral blood before and after therapy with thymopentin (TP5). All the lymphocyte subpopulations returned to normal range, except the CD5+ B cells, where the percentage remained abnormally high (60%). These data suggest that CD5+ B cells can be a useful monitoring index and confirm their important role in the pathogenesis of juvenile rheumatoid arthritis.
Ambrogi
F
F
Unità Operativa Allergologia Clinica, Università di Pisa, Italy.
Ricciardi
L
L
Nutini
P
P
Vanacore
R
R
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D015703:Antigens, CD / Q000032:analysis*; D001171:Arthritis, Juvenile / Q000188:drug therapy / Q000276:immunology*; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D016516:CD4-CD8 Ratio; D018956:CD5 Antigens; D002675:Child, Preschool; D005260:Female; D006801:Humans; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D015703:Antigens, CD; D018956:CD5 Antigens