Nodular sclerosing Hodgkin's disease and large cell lymphoma. Immunophenotypic characterization of a composite case.
Composite lymphomas have rarely been reported in Hodgkin's disease (HD), except in the lymphocyte predominance sub-type, and immunohistochemical investigations have been performed in only few cases. We describe the histological and immunophenotypical findings in a case of composite nodular sclerosing HD and high-grade, large cell non-Hodgkin's lymphoma (NHL). In our case HD and NHL cells displayed striking morphological and immunophenotypical divergence, suggesting a lack of correlation between the two neoplasms.
Paulli
M
M
Department of Anatomical Pathology, University of Pavia, I.R.C.C.S. Policlinico S. Matteo, Italy.
Rosso
R
R
Kindl
S
S
Boveri
E
E
Sirchi
M
M
De Medici
A
A
Invernizzi
R
R
Magrini
U
U
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D018951:Antigens, CD20; D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis; D000970:Antineoplastic Agents / Q000008:administration & dosage; D006684:HLA-DR Antigens / Q000032:analysis; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006689:Hodgkin Disease / Q000473:pathology*; D006801:Humans; D016256:Lewis X Antigen; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis; D018396:Mucin-1; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D010641:Phenotype; D012799:Sialyltransferases / Q000032:analysis; D000094802:beta-D-Galactoside alpha 2-6-Sialyltransferase
D015703:Antigens, CD; D018951:Antigens, CD20; D000944:Antigens, Differentiation, B-Lymphocyte; D000970:Antineoplastic Agents; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D016256:Lewis X Antigen; D008562:Membrane Glycoproteins; D018396:Mucin-1; C045084:invariant chain; D012799:Sialyltransferases; D000094802:beta-D-Galactoside alpha 2-6-Sialyltransferase