Thrombelastography after aspirin ingestion in pregnant and non-pregnant subjects.
The thrombelastograph (TEG) and bleeding time were performed before and 6 h after a single oral dose of aspirin 600 mg in a group of eight healthy volunteers and 12 pregnant patients. Measured TEG variables (r, k, r+k times and maximum amplitude) were unaltered after aspirin although there was a significant prolongation of the bleeding time in both groups. Although the TEG appeared not to detect aspirin-induced changes in platelet function, the TEG measures all phases of coagulation and the unaltered TEG after aspirin suggested a functioning coagulation system.
Orlikowski
C E
CE
Department of Anaesthetics, Faculty of Medicine, University of Natal, Durban, South Africa.
Payne
A J
AJ
Moodley
J
J
Rocke
D A
DA
D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology*; D001760:Bleeding Time; D001777:Blood Coagulation / Q000187:drug effects*; D001792:Blood Platelets / Q000187:drug effects; D005260:Female; D006801:Humans; D011247:Pregnancy / Q000097:blood*; D013916:Thrombelastography
D001241:Aspirin