Trisomy 2 as the sole chromosomal abnormality in a hepatoblastoma.
Short-term cultures of a fine-needle aspirate from a hepatoblastoma were analyzed cytogenetically. Trisomy 2 was found as the sole abnormality, yielding the karyotype 47,XY, + 2/46,XY. Because trisomy for all or part of chromosome 2 has been described, although together with other aberrations, in seven of the 11 hepatoblastomas hitherto reported, the finding of + 2 as the only anomaly in the present case strongly indicates that additional chromosome 2 material is of pathogenetic significance in this tumor type.
Bardi
G
G
Department of Clinical Genetics, University Hospital, Sweden.
Johansson
B
B
Pandis
N
N
Heim
S
S
Mandahl
N
N
Békássy
A
A
Hägerstrand
I
I
Mitelman
F
F
D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D002889:Chromosomes, Human, Pair 2; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D014314:Trisomy