The effects of diuretics on nasal transmucosal potential difference.
The effects of application of frusemide, amiloride and bumetanide on nasal transmucosal potential difference (NTPD), at rest and during exercise, were studied in 8 normal subjects. In a double-blind placebo controlled study, 8 volunteers had NTPD recorded at 4-min intervals during 12-min periods of rest, before and after treatment, during 12 min of exercise, and recovery. Application of placebo, frusemide and bumetanide did not significantly alter NTPD at rest. Amiloride caused a significant reduction (P less than 0.025). During exercise there was a significant rise in NTPD with placebo (P less than 0.05), frusemide (P less than 0.05) and amiloride (P less than 0.05). There was no increase in NTPD during exercise with bumetanide.
Stewart
E J
EJ
Eye and Ear Clinic, Royal Victoria Hospital, Belfast, Northern Ireland.
Cinnamond
M J
MJ
Nicholls
P
P
Stanford
C F
CF
D000328:Adult; D000584:Amiloride / Q000494:pharmacology; D002034:Bumetanide / Q000494:pharmacology; D004232:Diuretics / Q000494:pharmacology*; D005080:Exercise Test; D005665:Furosemide / Q000494:pharmacology; D006801:Humans; D007473:Ion Channels / Q000187:drug effects* / Q000378:metabolism; D007474:Ion Exchange; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009297:Nasal Mucosa / Q000187:drug effects* / Q000378:metabolism
D004232:Diuretics; D007473:Ion Channels; D002034:Bumetanide; D000584:Amiloride; D005665:Furosemide