title: The Wnt gene family in tumorigenesis and in normal development.
abstract: Various members of the Wnt gene family have been identified as activated oncogenes in mouse mammary tumors. We show that some tumors are oligoclonal for activation of a Wnt gene, and clonal variation when those tumors are transplanted to become hormone-independent. The normal function of many Wnt genes is to control pattern formation in early embryos, as shown by expression profiles and by mutant analysis.
authors.affiliation: Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University, CA 94305.
authors.forename: R
authors.initials: R
authors.lastname: Nusse
mesh_terms: D000818:Animals; D004330:Drosophila / Q000196:embryology / Q000235:genetics; D005314:Embryonic and Fetal Development / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D008325:Mammary Neoplasms, Experimental / Q000235:genetics; D051379:Mice; D005810:Multigene Family; D009857:Oncogenes; D011518:Proto-Oncogene Proteins / Q000235:genetics* / Q000502:physiology; D051153:Wnt Proteins; D029961:Zebrafish Proteins
chemical_list: D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; D029961:Zebrafish Proteins