title: Human muscle cell denervation: the results of a 31-phosphorus magnetic resonance spectroscopy study.
abstract: The results presented here demonstrate that there is a major abnormality of high and low energy phosphate metabolism in muscle following peripheral nerve damage. Using 31-phosphorus magnetic resonance spectroscopy the changes in phosphocreatine, adenosine triphosphate, inorganic phosphate and metabolites of membrane metabolism could be observed in vivo in human subjects. The data indicate that there may be a metabolic myopathy in the muscle cells after nerve injury. Further, the metabolic changes did not always return to the control level, indicating a persistence of the abnormality. This failure of the metabolic function of the cells may be important in determining the ultimate outcome of peripheral nerve surgery.
authors.affiliation: M.R.C. Biochemical and Clinical Magnetic Resonance Unit, John Radcliffe Hospital, Oxford.
authors.forename: S P
authors.initials: SP
authors.lastname: Frostick
authors.forename: D J
authors.initials: DJ
authors.lastname: Taylor
authors.forename: M J
authors.initials: MJ
authors.lastname: Dolecki
authors.forename: G K
authors.initials: GK
authors.lastname: Radda
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D009132:Muscles / Q000294:innervation* / Q000378:metabolism; D059348:Peripheral Nerve Injuries; D010710:Phosphates / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism; D010761:Phosphorus Radioisotopes / Q000378:metabolism; D013997:Time Factors
chemical_list: D010710:Phosphates; D010761:Phosphorus Radioisotopes; D010725:Phosphocreatine; D010758:Phosphorus; D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases