title: The cancer-associated retinopathy antigen is a recoverin-like protein.
abstract: Cancer-associated retinopathy (CAR) is a rare form of retinal degeneration that occurs in association with certain forms of cancer. CAR patients typically possess high titers of autoantibodies against a specific photoreceptor protein--the 23 kD retinal CAR antigen. The mechanisms involved in the vision loss experienced by CAR patients are not understood, but serologic studies indicate the process could include a series of autoimmune reactions directed at specific components of the retina. Because the retinal CAR antigen is the principal ocular autoantigen involved in the antibody response of CAR patients, characterizing it would contribute to the understanding of putative autoimmune involvement. Serum antibodies from CAR patients have been used to isolate the gene encoding the CAR antigen from a cDNA library of human retina. Nucleotide sequence analysis suggests that the CAR antigen shows approximately 90% homology to the published amino acid sequence of bovine recoverin.
authors.affiliation: Ophthalmology Research, University of California Davis Medical Center, Sacramento.
authors.forename: C E
authors.initials: CE
authors.lastname: Thirkill
authors.forename: R C
authors.initials: RC
authors.lastname: Tait
authors.forename: N K
authors.initials: NK
authors.lastname: Tyler
authors.forename: A M
authors.initials: AM
authors.lastname: Roth
authors.forename: J L
authors.initials: JL
authors.lastname: Keltner
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000912:Antibodies, Neoplasm / Q000276:immunology; D000951:Antigens, Neoplasm / Q000235:genetics* / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000276:immunology; D001483:Base Sequence; D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins / Q000235:genetics*; D005136:Eye Proteins; D051597:Hippocalcin; D006801:Humans; D007124:Immunoenzyme Techniques; D008074:Lipoproteins; D008253:Macaca mulatta; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins; D010257:Paraneoplastic Syndromes / Q000235:genetics / Q000276:immunology; D010786:Photoreceptor Cells / Q000276:immunology; D051603:Recoverin; D012162:Retinal Degeneration / Q000235:genetics / Q000276:immunology; D012689:Sequence Homology, Nucleic Acid
chemical_list: D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D001323:Autoantibodies; D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; D005136:Eye Proteins; D008074:Lipoproteins; D009419:Nerve Tissue Proteins; C496731:RCVRN protein, human; D051603:Recoverin; D051597:Hippocalcin