Electrophysiological follow-up of acute and chronic experimental allergic encephalomyelitis in the Lewis rat.
Cortical somatosensory evoked potentials (c-SEP) and flash visual evoked potentials (f-VEP) were serially recorded in acute monophasic and chronic relapsing experimental allergic encephalomyelitis (EAE) in the Lewis rat. In acute EAE, a significantly delayed latency and broadened peak of the c-SEP were observed corresponding to the clinical onset, and then returned to normal with the disappearance of clinical signs. In chronic EAE, the c-SEP showed the same changes as in acute EAE, also reflecting the first attack, remission and relapsing phase. However, chronic EAE, when paralysis had recovered in the relapsing phase, showed c-SEP abnormalities suggestive of subclinical active lesions. In contrast, the f-VEP showed no obvious abnormalities in acute or chronic EAE. These findings suggest that the c-SEP is an objective and sensitive index for detecting clinical and pathological changes in acute and chronic EAE in the Lewis rat.
Deguchi
K
K
Third Department of Internal Medicine, Kagawa Medical School, Japan.
Takeuchi
H
H
Miki
H
H
Yamada
A
A
Touge
T
T
Terada
S
S
Nishioka
M
M
D000818:Animals; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000175:diagnosis* / Q000503:physiopathology; D005073:Evoked Potentials, Somatosensory; D005074:Evoked Potentials, Visual; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009103:Multiple Sclerosis / Q000503:physiopathology; D051381:Rats; D011917:Rats, Inbred Lew; D012008:Recurrence