Lindane-induced modifications to membrane lipid structure: effect on membrane fluidity after subchronic treatment.
Chronic lindane intoxication by injecting subcutaneously the toxicant, resulted in an altered lipid pattern in rat ventral prostate membranes. An increase of membrane fluidity was also observed using a fluorescence polarization technique. When in vitro experiments were carried out with both treated and untreated rats, an interesting lack of parallelism was found, which could indicate the development of a resistance to membrane disordering by lindane. The observed changes in cholesterol and phospholipid composition are also consistent with the hypothesis that lindane perturbs the lipid matrix of membranes, possibly inducing complex compensatory changes in the membrane lipid composition.
Gutierrez-Ocaña
M T
MT
Departamento de Bioquímica y Biología Molecular, Universidad de Alcalá, Madrid, Spain.
Senar
S
S
Perez-Albarsanz
M A
MA
Recio
M N
MN
D000818:Animals; D005454:Fluorescence Polarization; D001556:Hexachlorocyclohexane / Q000494:pharmacology*; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects*; D008563:Membrane Lipids / Q000737:chemistry*; D010743:Phospholipids / Q000737:chemistry; D011467:Prostate / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
D008563:Membrane Lipids; D010743:Phospholipids; D001556:Hexachlorocyclohexane