title: Cholinesterases in the amyloid angiopathy of Alzheimer's disease.
abstract: Vessels affected by amyloid angiopathy in patients with Alzheimer's disease also displayed intense acetylcholinesterase and butyrylcholinesterase activity when examined by light and electron microscopy. The enzymatic properties of the vessel-bound cholinesterases were identical to those of the cholinesterases associated with senile plaques and neurofibrillary tangles. This cholinesterase activity is of unknown origin but represents one of the very few features common to all the major pathological markers of Alzheimer's disease.
authors.affiliation: Bullard and Denny-Brown Laboratory, Beth Israel Hospital, Boston, MA 02215.
authors.forename: M
authors.initials: M
authors.lastname: Mesulam
authors.forename: K
authors.initials: K
authors.lastname: Carson
authors.forename: B
authors.initials: B
authors.lastname: Price
authors.forename: C
authors.initials: C
authors.lastname: Geula
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications*; D000682:Amyloid; D002093:Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide / Q000494:pharmacology; D002091:Butyrylcholinesterase / Q000378:metabolism; D002802:Cholinesterases / Q000378:metabolism*; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008854:Microscopy, Electron; D013194:Staining and Labeling; D013770:Tetraisopropylpyrophosphamide / Q000494:pharmacology; D014652:Vascular Diseases / Q000201:enzymology* / Q000209:etiology
chemical_list: D000682:Amyloid; D002093:Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide; D013770:Tetraisopropylpyrophosphamide; D002091:Butyrylcholinesterase; D002802:Cholinesterases