[On the relation between substance P and physostigmine on cardiovascular control in rabbit brain].
Using an electromagnetic flowmeter technique, the cardiac output as measured by blood flow in the aortic arch was measured during intracerebroventricular injection (icv.) of Substance P (SP) and physostigmine in 47 anesthetized rabbits. Carotid artery blood pressure and heart rate were recorded. After icv of SP (20 micrograms/20 microliters) or physostigmine (60 micrograms/20 microliters), both cardiac output and mean artery pressure were increased. Pretreatment with icv. of atropine (150 micrograms/20 microliters) did not alter the effect of SP, but the effect of physostigmine was blocked by pretreatment with SP blocker (25 micrograms/20 microliters). These findings suggest that cerebral SP is involved in cholinergic mechanisms on the central control of blood pressure.
Yang
L P
LP
Department of Physiology, Zunyi Medical College.
Wen
Z Y
ZY
Yu
G Q
GQ
Tian
H
H
D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001921:Brain / Q000502:physiology; D002302:Cardiac Output / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D007276:Injections, Intraventricular; D010830:Physostigmine / Q000494:pharmacology*; D011817:Rabbits; D013373:Substance P / Q000494:pharmacology*
D013373:Substance P; D010830:Physostigmine; D000109:Acetylcholine