Amplification of genes within the chromosome 11q13 region is indicative of poor prognosis in patients with operable breast cancer.
Amplification of the chromosome 11q13 region, which harbors the BCL1 region and the PRAD1, EMS1, HSTF1, and INT2 genes, was found in 36 (16%) of a series of 226 breast carcinomas. In the 153 patients with stage I-IIIa disease who had received no therapy prior to surgery and who were treated with curative intent, 11q13 amplification was associated with the presence of lymph node metastases (P less than 0.002). The presence of an 11q13 amplification was associated with a significantly shorter relapse-free survival (P less than 0.002) and a higher breast cancer-specific mortality (P less than 0.003). Stepwise multivariate analysis showed that, in addition to lymph node status, 11q13 amplification was the best predictor for short survival. Stratified log-rank analysis indicated that, within the group of lymph node-positive breast cancer patients, 11q13 amplification identifies a subgroup at high risk.
Schuuring
E
E
Division of Tumor Biology, The Netherlands Cancer Institute, Amsterdam.
Verhoeven
E
E
van Tinteren
H
H
Peterse
J L
JL
Nunnink
B
B
Thunnissen
F B
FB
Devilee
P
P
Cornelisse
C J
CJ
van de Vijver
M J
MJ
Mooi
W J
WJ
D001943:Breast Neoplasms / Q000235:genetics* / Q000601:surgery; D002880:Chromosomes, Human, Pair 11 / Q000502:physiology*; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005784:Gene Amplification / Q000235:genetics*; D006801:Humans; D008408:Mastectomy; D011379:Prognosis
D004273:DNA, Neoplasm