title: Glycyrrhiza glabra extract as an effector of interception in Escherichia coli K12+.
abstract: Glycyrrhiza glabra polar lipid extract contains a number of flavonoids and related chemical compounds. Studies on the effectiveness of Glycyrrhiza glabra polar lipid extract in intercepting reactive molecules generated from the illumination of the photosensitizers rose bengal and phenosafranin indicate that it is effective in preventing cytotoxicity against E. coli K12+ in a dose-related fashion using illuminated rose bengal. Since only a modest scavenging of singlet oxygen generated from phenosafranin is observed, the effects of the extracts are less related to singlet oxygen-mediated oxidation of substrate (type II reactions) than non-singlet oxygen-mediated oxidation of substrate (type I reactions). Elevated levels of glutathione observed in exponentially growing cells of E. coli K12 were also observed.
authors.affiliation: Department of Microbiology, University of Kansas, Lawrence 66045.
authors.forename: S
authors.initials: S
authors.lastname: Kuo
authors.forename: D M
authors.initials: DM
authors.lastname: Shankel
authors.forename: H
authors.initials: H
authors.lastname: Telikepalli
authors.forename: L A
authors.initials: LA
authors.lastname: Mitscher
mesh_terms: D000975:Antioxidants; D004228:Dithionitrobenzoic Acid / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D005609:Free Radicals; D005978:Glutathione / Q000378:metabolism; D006035:Glycyrrhiza; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry; D010777:Photochemistry; D010936:Plant Extracts / Q000737:chemistry*; D010946:Plants, Medicinal; D012395:Rose Bengal / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D010936:Plant Extracts; D012395:Rose Bengal; D004228:Dithionitrobenzoic Acid; D005978:Glutathione; D010100:Oxygen