Circulating elevated levels of soluble CD23, interleukin-4, and CD20+CD23+ lymphocytes in atopic subjects with elevated serum IgE concentrations.
Circulating IgE protein levels, leukocyte counts, lymphocyte subsets, IL-4, and soluble CD23 levels were quantitated in 43 atopic and 19 nonatopic subjects. Mean values of IgE protein levels, total eosinophil counts, CD20+CD23+ cells (B cells with low-affinity IgE receptor), IL-4 and sCD23 levels were elevated in atopic patients compared with nonatopic controls. The results suggest that sCD23, IL-4, and CD20+CD23+ lymphocytes may play a role in the increased production of IgE in atopic subjects in a manner similar to that observed by other investigators in prior in vitro studies.
Reddy
M M
MM
R.A. Cooke Institute of Allergy, St. Luke's/Roosevelt Hospital, New York, New York.
Weissman
A M
AM
Mazza
D S
DS
Meriney
D K
DK
Johns
M
M
Carrabis
S
S
Grieco
M H
MH
D000328:Adult; D015703:Antigens, CD / Q000032:analysis*; D018951:Antigens, CD20; D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis*; D001491:Basophils / Q000166:cytology; D004804:Eosinophils / Q000166:cytology; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000097:blood*; D007073:Immunoglobulin E / Q000032:analysis*; D015847:Interleukin-4 / Q000097:blood*; D007958:Leukocyte Count; D016131:Lymphocyte Subsets / Q000276:immunology; D008214:Lymphocytes / Q000737:chemistry* / Q000276:immunology*; D008297:Male; D011961:Receptors, Fc / Q000032:analysis*; D017455:Receptors, IgE
D015703:Antigens, CD; D018951:Antigens, CD20; D000944:Antigens, Differentiation, B-Lymphocyte; D011961:Receptors, Fc; D017455:Receptors, IgE; D015847:Interleukin-4; D007073:Immunoglobulin E