Acute isopropanol ingestion: pharmacokinetic parameters in the infant.
We describe a case of isopropanol intoxication in a 2-month-old infant. The source of isopropanol and both the route and time of ingestion could be clearly identified. Serial measurements of isopropanol and acetone provided data for calculating their respective elimination half-lives. Isopropanol (half-life = 5.8 hr) clearance was similar to values reported for adults; acetone (half-life = 10.8 hr) was eliminated twice as rapidly as in adults.
Parker
K M
KM
Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City.
Lera
T A
TA
D000433:1-Propanol / Q000097:blood / Q000493:pharmacokinetics* / Q000506:poisoning*; D000096:Acetone / Q000097:blood; D004632:Emergency Medical Services; D005260:Female; D005751:Gastric Lavage; D006207:Half-Life; D006801:Humans; D007223:Infant; D008657:Metabolic Clearance Rate; D011041:Poisoning / Q000628:therapy
D000096:Acetone; D000433:1-Propanol