title: Abnormal cardiovascular responses induced by localized high power microwave exposure.
abstract: A hypothesis of microwave-induced circulatory under perfusion was tested in ketamine anesthetized rats whose heart rate, mean arterial pressure, pulse pressure, respiration rate, and body temperatures were monitored continuously. Fifty-eight ventral head and neck exposures in a waveguide consisted of sham-exposure and exposure to continuous wave (CW) and pulsed 1.25 GHz microwaves for 5 min. The 0.5 Hz (10 microseconds, 2 W average) and 16 Hz (1 microsecond, 6.4 W average) pulse-modulated microwaves were delivered at 400 kW peak power. The CW microwaves were 2 and 6.4 W. The average specific absorption rate was 4.75 W/kg per watt transmitted in the brain and 17.15 W/kg per watt transmitted in the neck. Respiration rate and mean arterial pressure were not altered. Changes in heart rate and pulse pressure were observed in rats exposed to higher power (16 Hz pulses and 6.4 W CW) but not to the lower average power microwaves (0.5 Hz pulses and 2 W CW). Depression of pulse pressure, an indication of a decrease in stroke volume, and increased (tachycardia) or decreased (bradycardia) heart rate were noted in presence of whole-body hyperthermia. The cardiac output of those animals exposed to higher average power microwaves was considered to be below normal as hypothesized. Decreased cardiac output and normal mean arterial pressure resulted in an increase in the total peripheral resistance which was contrary to the anticipated thermal response of animals.
authors.affiliation: ERC BioServices Corporation, Gaithersburg, MD 20879.
authors.forename: S T
authors.initials: ST
authors.lastname: Lu
authors.forename: D O
authors.initials: DO
authors.lastname: Brown
authors.forename: C E
authors.initials: CE
authors.lastname: Johnson
authors.forename: S P
authors.initials: SP
authors.lastname: Mathur
authors.forename: E C
authors.initials: EC
authors.lastname: Elson
mesh_terms: D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D006439:Hemodynamics / Q000502:physiology / Q000528:radiation effects; D008297:Male; D008872:Microwaves / Q000009:adverse effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013047:Specific Pathogen-Free Organisms / Q000502:physiology / Q000528:radiation effects