title: [A case of chronic toluene intoxication with atrophy of cerebrum, cerebellum and brainstem on CT and MRI].
abstract: A 28-year-old man developed neurological disorders consisting of cerebellar symptoms and dementia over a period of 8 years of inhalation of toluene. He also developed bilateral optic atrophy. CT scan and MRI revealed atrophy of cerebrum, cerebellum and brainstem. The severity of neurological symptoms corresponded with the findings of CT and MRI. Furthermore, MRI (T2) showed reduced signal intensity in bilateral thalamus. This patient was also admitted to another hospital 2.5 years ago. Compared with the previous findings, present examinations showed significant progress of the atrophy of cerebrum and brainstem. It was suggested from the results of ABR that the disturbance of the brainstem was aggravated through this period.
authors.affiliation: Department of Neuropsychiatry, School of Medicine, Kyorin University.
authors.forename: K
authors.initials: K
authors.lastname: Fujita
authors.forename: Y
authors.initials: Y
authors.lastname: Koga
authors.forename: K
authors.initials: K
authors.lastname: Takemasa
authors.forename: H
authors.initials: H
authors.lastname: Koike
authors.forename: J
authors.initials: J
authors.lastname: Akai
mesh_terms: D000328:Adult; D001284:Atrophy; D001921:Brain / Q000187:drug effects* / Q000473:pathology; D001933:Brain Stem / Q000187:drug effects* / Q000473:pathology; D002531:Cerebellum / Q000187:drug effects* / Q000473:pathology; D002908:Chronic Disease; D016057:Evoked Potentials, Auditory, Brain Stem; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011041:Poisoning / Q000473:pathology; D014050:Toluene / Q000506:poisoning*; D014057:Tomography, X-Ray Computed
chemical_list: D014050:Toluene