title: The innervation of the great saphenous vein: an immunohistochemical study with special regard to regulatory peptides.
abstract: The human great saphenous vein is often used in by-pass surgery. In spite of its importance little is known about the neuronal regulation and innervation of this vessel. On the other hand, therapeutic phlebectomy of the saphenous vein provides a good basis for investigations on the nervous supply of human veins. In former studies the human great saphenous vein has been proved to be a richly innervated portion of the low pressure vascular system. We studied the innervation of the proximal femoral saphenous vein by immunohistochemical methods and with special regard to regulatory neuropeptides. A peptidergic innervation mainly localized along the vasa vasorum and associated with immunoreactivity of substance P and CGRP was found which yields evidence for a mechanosensory innervation of this vascular segment.
authors.affiliation: Dermatologische Universitäts-Klinik Erlangen.
authors.forename: W M
authors.initials: WM
authors.lastname: Herbst
authors.forename: K P
authors.initials: KP
authors.lastname: Eberle
authors.forename: Y
authors.initials: Y
authors.lastname: Ozen
authors.forename: O P
authors.initials: OP
authors.lastname: Hornstein
mesh_terms: D015740:Calcitonin Gene-Related Peptide / Q000502:physiology*; D006801:Humans; D007124:Immunoenzyme Techniques; D009131:Muscle, Smooth, Vascular / Q000294:innervation* / Q000473:pathology; D010751:Phosphopyruvate Hydratase / Q000502:physiology*; D009418:S100 Proteins / Q000502:physiology*; D012501:Saphenous Vein / Q000294:innervation* / Q000473:pathology; D011984:Sensory Receptor Cells / Q000473:pathology; D013373:Substance P / Q000502:physiology*; D014648:Varicose Veins / Q000473:pathology; D014660:Vasoactive Intestinal Peptide / Q000502:physiology*
chemical_list: D009418:S100 Proteins; D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D010751:Phosphopyruvate Hydratase; D015740:Calcitonin Gene-Related Peptide