Circulating immune complexes in leukaemias and lymphomas.
Circulating immune complexes (ClC) were estimated in 78 patients of leukaemias and lymphomas by Clq deviation ELISA and PEG assay. In all leukaemias a significant elevation in ClC was seen at the time of first presentation. While in ALL a decrease occurred on therapy as partial or complete remission was achieved, no such fall was seen in AML or CML-BC when treated. ClC levels were much higher in non-Hodgkins lymphoma than in Hodgkins disease and showed a direct correlation with B symptoms and activity of the disease. The ClC levels were highest in null-ALL followed by those in common ALL and T-ALL. The mean duration of remission in patients of ALL without elevation in ClC was much longer than in those with ClC.
Kishore
J
J
Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow.
Kumar
R
R
Choudhry
V P
VP
Bhargava
M
M
D000936:Antigen-Antibody Complex / Q000032:analysis / Q000097:blood / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D002845:Chromatography; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D016130:Immunophenotyping; D007938:Leukemia / Q000145:classification / Q000175:diagnosis / Q000276:immunology*; D008223:Lymphoma / Q000175:diagnosis / Q000276:immunology*; D008297:Male; D011379:Prognosis
D000936:Antigen-Antibody Complex