title: Human cytotoxic T-lymphocytes specific for autologous follicular lymphoma recognize immunoglobulin in a major histocompatibility complex restricted fashion.
abstract: BACKGROUND
  Previously, autologous Burkitt lymphoma-specific cytotoxic T-lymphocytes (CTL) were found to express the gamma and delta T-cell receptor and recognize tumor idiotype in a major histocompatibility complex (MHC) unrestricted fashion.
  
  
  METHODS
  In this study, the authors established autologous CTL lines and clones specific for a B-cell follicular lymphoma.
  
  
  RESULTS
  These CTL are tumor specific and inhibited by antiimmunoglobulin monoclonal antibodies, but unlike the Burkitt lymphoma-specific CTL, they are MHC restricted and express the alpha and beta T-cell receptor.
  
  
  CONCLUSIONS
  These studies suggest that different B-cell lymphomas can induce CTL of different phenotypes and MHC restriction.
authors.affiliation: Department of Pediatrics, Stanford University, California 94305.
authors.forename: S
authors.initials: S
authors.lastname: Luna-Fineman
authors.forename: J E
authors.initials: JE
authors.lastname: Lee
authors.forename: P K
authors.initials: PK
authors.lastname: Wesley
authors.forename: C
authors.initials: C
authors.lastname: Clayberger
authors.forename: A M
authors.initials: AM
authors.lastname: Krensky
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D017252:CD3 Complex / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D002450:Cell Communication; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D006801:Humans; D007167:Immunotherapy; D016393:Lymphoma, B-Cell / Q000276:immunology* / Q000628:therapy; D008224:Lymphoma, Follicular / Q000276:immunology* / Q000628:therapy; D008285:Major Histocompatibility Complex / Q000276:immunology*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000032:analysis; D012074:Remission Induction; D013602:T-Lymphocytes, Cytotoxic / Q000737:chemistry / Q000276:immunology*; D014407:Tumor Cells, Cultured
chemical_list: D000911:Antibodies, Monoclonal; D017252:CD3 Complex; D016827:CD8 Antigens; D016693:Receptors, Antigen, T-Cell, alpha-beta