Adenosine and carnitine derivatives and calcium movements in rat heart sarcoplasmic reticulum.
Many researches indicate that some Ca antagonists modulate Ca fluxes not only at the level of the cytoplasmic membrane but also across the sarcoplasmic reticulum. The present study investigates whether certain compounds like propionylcarnitine or acetylcarnitine which have the capacity to influence cardiac activity might interfere with intracellular Ca movements. The results demonstrate that acetylcarnitine and propionylcarnitine do not affect the calcium intracellular movement in sarcoplasmic reticulum.
Bertelli
A
A
Department of Pharmacology, University of Milan, Italy.
Ronca-Testoni
S
S
Spaggiari
P G
PG
Zucchi
R
R
D000108:Acetylcarnitine / Q000494:pharmacology*; D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002331:Carnitine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010477:Perfusion; D051381:Rats; D017207:Rats, Sprague-Dawley; D012519:Sarcoplasmic Reticulum / Q000187:drug effects* / Q000378:metabolism
C003223:propionylcarnitine; D000108:Acetylcarnitine; D000241:Adenosine; D002331:Carnitine; D002118:Calcium