Research on heterocyclic compounds, XXIX. Synthesis and antiinflammatory activity of imidazo[1,2-a]pyrazine derivatives.
The reaction in anhydrous ethanol of some substituted 2-aminopyrazines with ethyl 2-benzoyl-2-bromoacetate or with ethyl 3-bromo-4-oxopentanoate afforded a group of ethyl 2-phenylimidazo[1,2-a]pyrazine-3-carboxylates and a group of ethyl 2-methylimidazo[1,2-a]pyrazine-3-acetates, respectively. The corresponding acids obtained via alkaline hydrolysis were subjected to pharmacological testing in vivo in order to evaluate their antiinflammatory activity.
Abignente
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E
Dipartimento di Chimica Farmaceutica e Tossicologica, Facoltà di Farmacia Università di Napoli Federico II.
De Caprariis
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P
Rimoli
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MG
Capasso
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F
Autore
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G
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000473:pathology; D011719:Pyrazines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011719:Pyrazines; D002351:Carrageenan