Acute myelogenous leukemia (AML) and diabetes insipidus (DI): further association with monosomy 7.
Diabetes insipidus (DI) is a rare complication of acute myelogenous leukemia (AML). Five of the six such cases described in the literature who had banded chromosomal studies performed had monosomy 7 and the sixth patient had del(7)(q22). A further case of AML complicated by DI in whom banded chromosomal studies revealed a complex karyotypic abnormality, including monosomy 7, is reported. The association between monosomy 7 and DI in AML appears specific but the reason for this association remains unclear.
Slater
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SE
ICRF Department of Medical Oncology, St Bartholomew's Hospital, West Smithfield, London, U.K.
Maccallum
P K
PK
Birjandi
F
F
Gibbons
B
B
Lister
T A
TA
D002897:Chromosomes, Human, Pair 7; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000235:genetics*; D008875:Middle Aged; D009006:Monosomy / Q000235:genetics*