Influence of chromatin molecular changes on RNA synthesis during embryonic development.
Two aspects of the chromatin repeat length (rl) are discussed: (i) Why is rl longer for slowly dividing cells than in rapidly dividing cells?, and (ii) Why is the temporal evolution of rl a decreasing function of time (t) in mammalian cortical neurons, whereas it is an increasing function of t for granule cells around the time of birth? These questions are discussed in terms of a hypothesis which assumes a correlation between deoxyribonucleic acid (DNA) packaging, transcription, and replication.
Chela-Flores
J
J
International Centre for Theoretical Physics, Trieste, Italy.
D000818:Animals; D001921:Brain / Q000196:embryology; D002843:Chromatin / Q000502:physiology*; D004261:DNA Replication / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology; D008322:Mammals / Q000196:embryology* / Q000235:genetics; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D014158:Transcription, Genetic / Q000502:physiology
D002843:Chromatin; D012313:RNA