Activation of the glutamate metabotropic receptor protects retina against N-methyl-D-aspartate toxicity.
Intraocular pretreatment with the specific metabotropic glutamate receptor agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) in the adult rat reduced the excitotoxic effects induced in the retina by a single intraocular injection of N-methyl-D-aspartate (NMDA). Damage was estimated by assessing NMDA-induced loss of retinal choline acetyltransferase (ChAT) activity. The interaction between metabotropic and ionotropic glutamate receptors may, therefore, be considered an important target for in vivo pharmacological neuroprotection.
Siliprandi
R
R
Fidia Research Laboratories, Abano Terme, PD, Italy.
Lipartiti
M
M
Fadda
E
E
Sautter
J
J
Manev
H
H
D000818:Animals; D003515:Cycloleucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D016202:N-Methylaspartate / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D017470:Receptors, Glutamate / Q000187:drug effects*; D012160:Retina / Q000187:drug effects*
D017470:Receptors, Glutamate; D003515:Cycloleucine; C036361:1-amino-1,3-dicarboxycyclopentane; D016202:N-Methylaspartate