[Protection on experimental sinus node dysfunction in rabbits with ginsenosides].
This experiment was carried out to evaluate the effect of ginsenosides from stems and leaves (GSL) on the sinus node dysfunction (SND) by observing the changes of the electrophysiological parameters of sinus node in limited period. Anesthetized rabbits were randomly divided into 3 groups. In the acute experiment, GSL, 50 mg/kg, iv, was given to the GSL group (G), n = 12. Normal saline (NS), the same volume, to the control group (C), n = 12. After GSL was administered 30-50 mg/kg.d for 14 days, iv, another data were obtained from chronic experimental group (CE), n = 15. The results show that the parameters, spontaneous cycle length (SCL), maximal sinus node recovery time (SNRTmax), corrected sinus node recovery time (CSNRT) were shorter in G group and CE group than C group respectively (P less than 0.05, P less than 0.01). It was suggested that GSL exerted protective effects on the experimental sinus node dysfunction.
Gao
D
D
Cardiocerebrovascular Institute, Second Affiliated Hospital, Zhejiang Medical University, Hangzhou.
Lou
F
F
Jin
F
F
D000818:Animals; D004594:Electrophysiology; D036145:Ginsenosides; D006327:Heart Block / Q000188:drug therapy; D011817:Rabbits; D012503:Saponins / Q000494:pharmacology* / Q000627:therapeutic use; D012849:Sinoatrial Node / Q000187:drug effects* / Q000503:physiopathology
D036145:Ginsenosides; D012503:Saponins