title: Mechanism of bradycardia-dependent appearance of manifest extrasystoles in concealed bigeminy. A theoretical model derived from the concepts of longitudinal dissociation and multilevel block in the reentrant pathway of extrasystoles.
abstract: A case of bradycardia-dependent appearance of manifest extrasystoles in concealed bigeminy is presented. To explain the mechanism of such bradycardia-dependent appearance, a theoretical model is derived from the concepts of "longitudinal dissociation" and "multilevel block" in the reentrant pathway of extrasystoles. In the theoretical model, functional longitudinal dissociation divides the reentrant pathway into dual pathways F and S. When manifest extrasystoles are not found for a long time, alternate sinus impulses pass through both pathways F and S, but become concealed extrasystoles because of insufficient conduction delay in the pathways. The other alternate sinus impulses are blocked in the pathways; in pathway F, the impulses are blocked at the entrance, while in pathway S, the impulses are blocked at a more distal level. When sinus cycles gradually lengthen, one of such alternate sinus impulses passes through the entrance of pathway F and, traveling very slowly, is blocked at a more distal level. The next sinus impulse is blocked at the entrance of pathway F; namely, 3:2 Wenckebach block occurs at the entrance of pathway F. Thus this sinus impulse enters only pathway S and passes through pathway S with enough conduction delay to become a manifest reentrant extrasystole.
authors.affiliation: Health Administration Center, Hokkaido University, Sapporo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kinoshita
authors.forename: G
authors.initials: G
authors.lastname: Konishi
authors.forename: F
authors.initials: F
authors.lastname: Okada
mesh_terms: D001919:Bradycardia / Q000150:complications / Q000503:physiopathology*; D005117:Cardiac Complexes, Premature / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D008962:Models, Theoretical