[Effects of magnesium and nickel ions on penicillin-induced focal epileptic activity in the cerebral cortex of rats].
In experiments on freely moving male Wistar rats on the model of penicillin-induced focal epileptic activity (EA) (the application onto the sensorimotor cortex of a filter paper soaked with benzylpenicillin sodium salt solution) it was shown that addition of MgSO4 (series 1) and NiCl2 (series 2) into the solution of penicillin significantly weakened EA. The combination of Mg2+ and Ni2+ with penicillin (series 3) produced a more significant suppression of EA as compared with separate application of the above-mentioned ions: the latency period of appearance of interictal discharges (IID) increased, the frequency and amplitude of IID decreased much more, no ictal discharges appeared in any animal, the duration of epileptic foci reduced to a much greater extent. This effect can be explained by the blockade of Ca current by the above-mentioned ions. One can suppose that the amplification of antiepileptic effects of combined action of Mg2+ and Ni2+ was due to an increase in the number of blocked voltage-dependent and NMDA-operated calcium channels.
Kryzhanovskiĭ
G N
GN
Karpova
M N
MN
Ozerova
I B
IB
Glebov
R N
RN
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology*; D004338:Drug Combinations; D004828:Epilepsies, Partial / Q000139:chemically induced / Q000503:physiopathology*; D008274:Magnesium / Q000494:pharmacology*; D008297:Male; D009532:Nickel / Q000494:pharmacology*; D010400:Penicillin G; D051381:Rats; D017208:Rats, Wistar
D004338:Drug Combinations; D009532:Nickel; D008274:Magnesium; D010400:Penicillin G