Pineal tumors.
Tissue diagnosis is necessary for optimal treatment of pineal region tumors in children. Preoperative staging should include craniospinal MR imaging with and without gadolinium DTPA enhancement, CSF sampling for cytology, and measurement of biologic tumor markers in serum and CSF. Surgical approach is determined by results of preoperative MR imaging and the extent of resection by the results of staging and intraoperative frozen-section histopathologic evaluation. There is no longer a role for the radiation test dose (2000 cGy) in the management of these tumors. Postoperative treatment is based on histopathology and extent of disease. Benign tumors are treated with surgery only, and nondisseminating focal tumors with surgery and focal radiation therapy. Non-germinoma malignant germ cell tumors are best treated with neoadjuvant chemotherapy followed by radiation therapy given focally for focal disease; craniospinal radiation therapy is reserved for patients with evidence of disseminated disease at the completion of induction chemotherapy.
Baumgartner
J E
JE
Department of Neurosurgery, University of California, School of Medicine, San Francisco.
Edwards
M S
MS
D001254:Astrocytoma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D002648:Child; D003399:Craniotomy; D006801:Humans; D008279:Magnetic Resonance Imaging; D010870:Pineal Gland / Q000473:pathology / Q000601:surgery*; D010871:Pinealoma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D011379:Prognosis
D014408:Biomarkers, Tumor