Novel version of Multiple Antigenic Peptide allowing incorporation on a cysteine functionalized lysine tree.
A novel version of Multiple Antigenic Peptide (MAP) is described. This approach consists of the synthesis of a properly functionalized antigen carrier and the incorporation, on request, of one or more activated antigenic peptides. This method was to synthesize a MAP containing eight epitopes of Hsp 70-1 from Plasmodium falciparum. Mice immunised with this MAP gave a specific response while those immunised with the peptide alone did not.
Baleux
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F
Department of Organic Chemistry, Pasteur Institute, Paris, France.
Dubois
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P
D000595:Amino Acid Sequence; D000818:Animals; D000913:Antibodies, Protozoan / Q000276:immunology; D000941:Antigens / Q000008:administration & dosage / Q000737:chemistry* / Q000276:immunology; D000953:Antigens, Protozoan / Q000276:immunology; D003545:Cysteine / Q000031:analogs & derivatives / Q000138:chemical synthesis; D000939:Epitopes / Q000276:immunology; D005260:Female; D006360:Heat-Shock Proteins / Q000276:immunology; D007114:Immunization; D008239:Lysine; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis* / Q000276:immunology / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000276:immunology
D000913:Antibodies, Protozoan; D000941:Antigens; D000953:Antigens, Protozoan; D000939:Epitopes; D006360:Heat-Shock Proteins; D010455:Peptides; C062289:S-(3-nitro-2-pyridinesulfenyl)cysteine; D008239:Lysine; D003545:Cysteine