Effect of caffeine and isobutyl-methyl-xanthine on production of binucleate cells and on post-replicative repair.
Caffeine (CAF) but not 3-isobutyl 1-methyl-xanthine (IBMX) displayed a strong DNA anti-repair effect in G2 prophase, as estimated by the frequency of abnormal chromosomes in anaphase-telophase found shortly after treatment. IBMX is more effective than CAF in inhibiting cytokinesis, while the binucleate cells formed by a short treatment with any of these two xanthines have similar cycle kinetics.
Grenet
J
J
Departamento Biomédico, Facultad de la Salud, Universidad de Antofagasta, Chile.
De La Torre
C
C
Sans
J
J
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology*; D000490:Allium / Q000166:cytology / Q000187:drug effects; D002110:Caffeine / Q000494:pharmacology*; D002453:Cell Cycle; D002478:Cells, Cultured; D004260:DNA Repair / Q000187:drug effects*; D016195:G2 Phase / Q000187:drug effects*; D011418:Prophase / Q000187:drug effects
D002110:Caffeine; D015056:1-Methyl-3-isobutylxanthine