title: A population-based case-control study of cancers of the nasal cavity and paranasal sinuses in Shanghai.
abstract: A population-based case-control study of cancer of the nasal cavity and sinuses, involving interviews of 60 incident cases and 414 controls, was conducted in Shanghai. Cigarette smoking was associated with a mild elevation in risk of squamous-cell carcinoma but not cancers of other cell types. Occupational exposures to wood and silica dusts and to petroleum products, and the use of wood and straw as cooking fuel, were linked to moderate increases in risk, while 4-fold or greater increases were associated with a history of chronic nasal diseases, including those occurring 10 or more years prior to cancer diagnosis. Dietary analyses revealed a significant protective effect of consumption of allium vegetables, oranges and tangerines, with a 50% reduced risk of nasal cancer among individuals in the highest intake group of these foods. Consumption of salt-preserved vegetables, meat and fish was associated with a significantly increased risk of nasal cancer in a dose-response fashion, with a 5-fold excess observed for the heaviest intake of these salted foods. These findings suggest that dietary factors may contribute to the development of nasal cancer.
authors.affiliation: Shanghai Cancer Institute, Department of Epidemiology, People's Republic of China.
authors.forename: W
authors.initials: W
authors.lastname: Zheng
authors.forename: W J
authors.initials: WJ
authors.lastname: Blot
authors.forename: X O
authors.initials: XO
authors.lastname: Shu
authors.forename: E L
authors.initials: EL
authors.lastname: Diamond
authors.forename: Y T
authors.initials: YT
authors.lastname: Gao
authors.forename: B T
authors.initials: BT
authors.lastname: Ji
authors.forename: J F
authors.initials: JF
authors.lastname: Fraumeni
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D004032:Diet; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity; D009669:Nose Neoplasms / Q000453:epidemiology* / Q000209:etiology; D016273:Occupational Exposure; D010255:Paranasal Sinus Neoplasms / Q000453:epidemiology* / Q000209:etiology; D012306:Risk; D012907:Smoking / Q000009:adverse effects