Immune surveillance against Epstein-Barr virus.
Following primary infection, EBV retains a life-long latent association with B lymphocytes and a permissive association with stratified epithelium in the oropharynx. This review presents a model for the host-virus relationships in healthy virus carriers, a relationship which, if perturbed, may result in EBV-associated disease. Cytotoxic T cells that recognise virally-determined epitopes on infected cells are the major effector arm and control the persistant infection. A strategy for developing a vaccine to EBV is discussed.
Moss
D J
DJ
Queensland Institute of Medical Research, Herston, Brisbane, Australia.
Burrows
S R
SR
Khanna
R
R
Misko
I S
IS
Sculley
T B
TB
D000595:Amino Acid Sequence; D000956:Antigens, Viral / Q000096:biosynthesis / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology / Q000382:microbiology; D002353:Carrier State / Q000276:immunology / Q000382:microbiology; D004848:Epithelium / Q000382:microbiology; D000939:Epitopes / Q000276:immunology; D015967:Gene Expression Regulation, Viral; D006566:Herpesviridae Infections / Q000276:immunology* / Q000382:microbiology; D004854:Herpesvirus 4, Human / Q000276:immunology* / Q000502:physiology; D006801:Humans; D007108:Immune Tolerance; D007157:Immunologic Surveillance; D007244:Infectious Mononucleosis / Q000276:immunology / Q000382:microbiology; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000276:immunology / Q000382:microbiology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014764:Viral Proteins / Q000096:biosynthesis / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology; D014779:Virus Replication
D000956:Antigens, Viral; D000939:Epitopes; D014764:Viral Proteins; D014765:Viral Vaccines