title: [Changes in left ventricular filling after acute increase of afterload in essential arterial hypertension with or without left ventricular hypertrophy].
abstract: It is debatable whether a direct causal link exists between left ventricular hypertrophy (LVH) and abnormal left ventricular filling (LVF) in arterial hypertension (AH). To assess if LVH is responsible for peculiar patterns of LVF, we examined 30 selected subjects, similar in age and body surface area, by Doppler echocardiography: 10 hypertensives (SBP: 158 +/- 15; DBP: 105 +/- 7 mmHg) with LVH (IM: 154 +/- 19 mg/m2) (Group 1); 10 hypertensives (SBP: 157 +/- 9; DBP: 101 +/- 5 mmHg) without LVH (IM: 105 +/- 17 mg/m2; Group 2); 10 normotensives without familiar history of AH (Group 3). LVF was analyzed in baseline conditions and during transient afterload increase, obtained by isometric exercise (handgrip, HG, for 5 min at 30% of maximal effort). At rest: 1) A wave peak velocity resulted significantly higher (p less than 0.01) in Group 1 (61 +/- 3 cm/s) versus Group 3 (52 +/- 7 cm/s), and E wave peak velocity was significantly lower in Group 1 (58 +/- 13 cm/s) versus Group 3 (74 +/- 10 cm/s); 2) Group 2 values (E wave: 66 +/- 12; A wave: 58 +/- 15 cm/s) were intermediate between those of groups 1 and 3, and with no significant differences; 3) E/A ratio resulted significantly lower both in Group 1 (1.04 +/- 0.2) and Group 2 (1.21 +/- 0.2) versus Group 3 (1.6 +/- 0.4).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Istituto di Malattie dell'Apparato Cardiovascolare, Università degli Studi, Bari.
authors.forename: G
authors.initials: G
authors.lastname: Antonelli
authors.forename: M
authors.initials: M
authors.lastname: Campaniello
authors.forename: N
authors.initials: N
authors.lastname: Di Venere
authors.forename: A
authors.initials: A
authors.lastname: Di Masi
authors.forename: D
authors.initials: D
authors.lastname: Carretta
authors.forename: G
authors.initials: G
authors.lastname: Santoro
authors.forename: P C
authors.initials: PC
authors.lastname: Dicillo
authors.forename: S
authors.initials: S
authors.lastname: Cesario
authors.forename: P
authors.initials: P
authors.lastname: Rizzon
mesh_terms: D001794:Blood Pressure; D006332:Cardiomegaly / Q000209:etiology / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D016277:Ventricular Function, Left