Inhibitory effect of morphine on yawning induced by cholinoceptor and dopamine D2 receptor activation in rats.
1. Bromocriptine (2, 4 and 8 mg kg-1, i.p.), physostigmine (0.05, 0.1 and 0.2 mg kg-1, i.p.) and pilocarpine (1, 3 and 5 mg kg-1, i.p.) induced dose-dependent yawning in rats. 2. These responses were reduced in a dose-dependent manner by pretreatment with morphine. 3. The inhibitory effect of morphine was reversed by naloxone. 4. Naloxone alone induced slight but significant yawning. 5. The present results suggest that morphine inhibits yawning in rats at an opiate receptor downstream from the sites at which cholinoceptor and dopamine D2 activation induce yawning. The anatomical location of these sites remains to be established.
Zarrindast
M R
MR
Department of Pharmacology, Medical Faculty, University of Tehran, Iran.
Jamshidzadeh
A
A
D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D010830:Physostigmine / Q000494:pharmacology; D010862:Pilocarpine / Q000494:pharmacology; D051381:Rats; D011950:Receptors, Cholinergic / Q000187:drug effects*; D011954:Receptors, Dopamine / Q000187:drug effects*; D017448:Receptors, Dopamine D2; D015000:Yawning / Q000187:drug effects*
D011950:Receptors, Cholinergic; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D010862:Pilocarpine; D009270:Naloxone; D001971:Bromocriptine; D009020:Morphine; D010830:Physostigmine