title: Olfactory bulb transplantation into the olfactory bulb of neonatal rats: a WGA-HRP study.
abstract: After unilateral bulbectomy in neonatal (P1-P5) rats, autoradiographically prelabeled presumptive olfactory bulbs from E15 and E17 embryos were transplanted in place of the removed tissue. After 2-7 months, the animals received injections of wheat germ agglutinin-horseradish peroxidase (WGA-HRP) into the piriform cortex. Nine of the twenty animals revealed WGA-HRP-positive neurons among neurons autoradiographically labeled, providing thus evidence that the axons of the output neurons from the homotopically transplanted olfactory bulb reconnect with the host piriform cortex.
authors.affiliation: Department of Biological Sciences, Florida State University, Tallahassee 32306.
authors.forename: T
authors.initials: T
authors.lastname: Zigova
authors.forename: P P
authors.initials: PP
authors.lastname: Graziadei
authors.forename: A G
authors.initials: AG
authors.lastname: Monti-Graziadei
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001345:Autoradiography; D016380:Brain Tissue Transplantation / Q000502:physiology*; D016332:Fetal Tissue Transplantation / Q000502:physiology*; D006651:Histocytochemistry; D006735:Horseradish Peroxidase; D009830:Olfactory Bulb / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013936:Thymidine / Q000378:metabolism; D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; D014909:Wheat Germ Agglutinins
chemical_list: D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; D014909:Wheat Germ Agglutinins; D006735:Horseradish Peroxidase; D013936:Thymidine