Evidence for pulsatile secretion of human atrial natriuretic peptide in healthy subjects.
The secretion pattern of human atrial natriuretic peptide (hANP) was investigated in 8 healthy male volunteers. Blood was drawn in 2 minute intervals for 90 minutes and in a second study in 4 minute intervals for 180 minutes. Base-line hANP plasma levels varied in a pulsatile secretion pattern of regular pulses every 9 +/- 1 minutes. Additionally long-term oscillations of 34 +/- 4 minutes were found. These data suggest that under basal conditions hANP varies in a pulsatile fashion.
Haak
T
T
Department of Endocrinology, Johann Wolfgang Goethe-University, Frankfurt am Main/Germany.
Jungmann
E
E
Schöffling
K
K
Usadel
K H
KH
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood* / Q000378:metabolism; D006321:Heart / Q000502:physiology; D006801:Humans; D008297:Male; D009206:Myocardium / Q000378:metabolism; D011673:Pulsatile Flow / Q000502:physiology*; D013997:Time Factors
D009320:Atrial Natriuretic Factor