[The effect of indomethacin and iloprost on the cardiodepressive actions of various anesthetics on isolated atrial preparations from guinea pigs].
Effects of Indomethacin and Iloprost on the Cardiodepressant Properties of Various Narcotics on Isolated Auricle Preparations from Guinea Pigs. In isolated auricle preparations from guinea pigs several narcotics (hexobarbital, pentobarbital, ketamine, etomidate, urethane) dose-dependently showed cardiodepressive effects. Premedication of the preparations with indomethacin significantly reduced the narcotics-induced changes of the cardiac action. Iloprost, a stable prostacyclin analogon, had the same efficacy. The influence of both substances could be due to an unspecific membrane effect or a positive inotropic action.
Burk
S A
SA
Institut für Pharmakologie und Toxikologie, Martin-Luther-Universität, Halle-Wittenberg.
Mentz
P
P
D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006325:Heart Atria / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D016285:Iloprost / Q000494:pharmacology*; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D011229:Preanesthetic Medication
D000777:Anesthetics; D000889:Anti-Arrhythmia Agents; D016285:Iloprost; D007213:Indomethacin