[A case of HBsAg positive liver cirrhosis who died after withdrawal of steroid].
A 42-year-old male was admitted with subarachnoidal hemorrhage. Dexamethasone 224 mg was used to reduce brain edema. His operation was successful without blood transfusion. No remarkable signs and symptoms were found except HBsAg positive and mild GPT elevation during his admission. He was discharged on the 33rd day. But 2 weeks later, he felt general fatigue and became worse day by day. He was re-admitted on the 75th day. Several therapies were given but he died of hepatic failure on the 85th day. The autopsy showed liver cirrhosis with massive necrosis. We believed that the steroid-withdrawal-phenomenon caused excessive immunological response and this process caused his hepatic failure leading to death.
Kumada
K
K
Department of Internal Medicine, Nagoya City Moriyama General Hospital.
Mizokami
M
M
Orito
E
E
Kamejima
N
N
Yamamoto
M
M
Oba
K
K
Tokuda
Y
Y
Suzuki
K
K
Narita
M
M
Mizuno
M
M
D000328:Adult; D001929:Brain Edema / Q000188:drug therapy; D002353:Carrier State / Q000276:immunology; D003907:Dexamethasone / Q000009:adverse effects*; D006509:Hepatitis B / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D013375:Substance Withdrawal Syndrome / Q000209:etiology*
D006514:Hepatitis B Surface Antigens; D003907:Dexamethasone