The 14th C. L. Oakley Lecture. Candida albicans HSP 90: link between protective and auto immunity.
Heat shock proteins (HSP) are thought to play a role in the aetiology of autoimmune diseases, but are also common targets for the immune response to many infections. Patients recovering from systemic candidosis produce antibodies to Candida albicans HSP 90, both to species-specific epitopes and, more commonly, to epitopes shared with human HSP 90. One such autoreactive antibody was protective in a mouse model of systemic candidosis.
Matthews
R C
RC
Department of Medical Microbiology, University of Manchester.
D000818:Animals; D000946:Antigens, Fungal / Q000276:immunology; D015551:Autoimmunity; D002176:Candida albicans / Q000276:immunology*; D002177:Candidiasis / Q000276:immunology; D000939:Epitopes; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans
D000946:Antigens, Fungal; D000939:Epitopes; D006360:Heat-Shock Proteins