On the rat model of human osteopenias and osteoporoses.
The idea that rats cannot model human osteopenias errs. The same mechanisms control gains in bone mass (longitudinal bone growth and modeling drifts) and losses (BMU-based remodeling), in young and aged rats and humans. Furthermore, they respond similarly in rats and man to mechanical influences, hormones, drugs and other agents.
Frost
H M
HM
Department of Orthopaedic Surgery, Southern Colorado Clinic, Pueblo.
Jee
W S
WS
D000328:Adult; D000818:Animals; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000503:physiopathology; D016723:Bone Remodeling; D002648:Child; D002675:Child, Preschool; D004195:Disease Models, Animal; D006801:Humans; D010024:Osteoporosis / Q000503:physiopathology; D051381:Rats