Granulomatous hypersensitivity to protamine as a complication of insulin therapy.
A patient is described who developed a granulomatous skin reaction to injections of protamine-insulin for the treatment of her diabetes mellitus. By means of skin testing it was shown that this reaction was caused by protamine. No adverse effects were seen when she was injected with insulin which did not contain protamine.
Hulshof
M M
MM
Department of Dermatology, Eemland Hospital, Amersfoort, The Netherlands.
Faber
W R
WR
Kniestedt
W F
WF
Boeree
M J
MJ
Kreek
P
P
D000368:Aged; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006099:Granuloma / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D011479:Protamines / Q000009:adverse effects*; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000139:chemically induced* / Q000473:pathology
D007328:Insulin; D011479:Protamines