title: Complex chromosomal rearrangements in an unusual variant of hairy cell leukemia.
abstract: An unusual case of variant HCL with multiple ribosomal lamellar complexes and complex chromosomal changes is described. The karyotype of the main cell clone is characterized by involvement of chromosome 5 at q13.3 and interstitial deletion of 7q. However, there is no other evidence of myelodysplasia and the abnormal cells are of lymphoid origin with a B-cell immunophenotype. The clonal chromosomal evolution involves rearrangements at sites known to be specifically altered in lymphoid tumors.
authors.affiliation: University of Cambridge Department of Haematology, MRC Centre, U.K.
authors.forename: E
authors.initials: E
authors.lastname: Nacheva
authors.forename: P
authors.initials: P
authors.lastname: Fischer
authors.forename: S
authors.initials: S
authors.lastname: O'Connor
authors.forename: D
authors.initials: D
authors.lastname: Bloxham
authors.forename: C
authors.initials: C
authors.lastname: Hoggarth
authors.forename: R
authors.initials: R
authors.lastname: Marcus
mesh_terms: D000368:Aged; D002869:Chromosome Aberrations; D002895:Chromosomes, Human, Pair 5; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D007943:Leukemia, Hairy Cell / Q000235:genetics* / Q000473:pathology