title: The effect of a protein meal on zidovudine pharmacokinetics in HIV-infected patients.
abstract: Eleven HIV-infected men participated in a randomized, two-treatment, two-period crossover study to determine the effect of a 25 g protein meal on zidovudine pharmacokinetics. On two separate occasions, 1 week apart, each patient received 200 mg zidovudine in a fasting state or immediately following the protein meal. A protein meal significantly decreased Cmax [532 (228 s.d.) vs 802 (452 s.d.) ng ml-1, P = 0.004] and increased mean residence time (138 (26 s.d.) vs 114 (26 s.d.) min, corrected for lag times, P = 0.001). However, AUC, tmax, terminal half-life and renal clearance were not significantly altered (P greater than 0.05). The power to detect a 20% change in AUC was 98% at the 5% significance level. In contrast to fat-containing foods, protein-based meals may not alter the extent of zidovudine absorption.
authors.affiliation: Department of Medicine, Ottawa General Hospital, Ontario, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Sahai
authors.forename: K
authors.initials: K
authors.lastname: Gallicano
authors.forename: G
authors.initials: G
authors.lastname: Garber
authors.forename: I
authors.initials: I
authors.lastname: McGilveray
authors.forename: N
authors.initials: N
authors.lastname: Hawley-Foss
authors.forename: N
authors.initials: N
authors.lastname: Turgeon
authors.forename: D W
authors.initials: DW
authors.lastname: Cameron
mesh_terms: D004044:Dietary Proteins / Q000008:administration & dosage*; D015658:HIV Infections / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D008297:Male; D015215:Zidovudine / Q000493:pharmacokinetics*
chemical_list: D004044:Dietary Proteins; D015215:Zidovudine