Effect of testosterone on the development of bladder tumors and calculi in female rats.
In order to study the effect of testosterone on bladder calculi and tumor formation in female rats, Wistar rats were administered testosterone for 12, 18 or 24 weeks. Testosterone was found to increase the incidence of both bladder calculi and tumors in intact, but not in oophorectomized rats. It is suggested that testosterone in combination with estrogen may contribute to hyperplasia formation, in turn leading to an increased incidence of bladder calculi and tumors.
Terada
S
S
Department of Obstetrics and Gynecology, Kanazawa University, School of Medicine, Japan.
Suzuki
N
N
Uchide
K
K
Akasofu
K
K
Nishida
E
E
D000818:Animals; D002291:Carcinoma, Papillary / Q000139:chemically induced* / Q000453:epidemiology / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D006965:Hyperplasia; D015994:Incidence; D010052:Ovariectomy; D010212:Papilloma / Q000139:chemically induced* / Q000453:epidemiology / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012307:Risk Factors; D012737:Sex Factors; D013739:Testosterone; D001744:Urinary Bladder Calculi / Q000139:chemically induced* / Q000453:epidemiology; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000453:epidemiology / Q000473:pathology
D013739:Testosterone