Anticlastogenic effects of a polyvitamin product, 'Pharmavit', on gamma-ray induction of somatic and germ cell chromosome aberrations in the mouse.
The polyvitamin product 'Pharmavit' (Pv), comprising vitamins A, D2, B1, B2, B6, C, E, nicotinamide, and calcium pantothene, was tested for anticlastogenic properties against gamma-rays in mice. Pretreatment with Pv consisted of daily administration by gavage for 30 days at dose levels corresponding to clinical recommendations for an adult human, as recalculated in terms of mg/kg. Findings indicated a reduction of chromosome aberrations in bone marrow cells from mice exposed to 3.0 Gy 137Cs gamma-rays; the reduction concerned predominantly fragments of the chromatid type. Furthermore, a reduction factor of 1.6 was obtained for the frequency of reciprocal translocations induced by spermatogonial irradiation in mice exposed to 4.0 Gy gamma-rays. Pretreatment with vitamin C alone, at the dose present in Pv, proved nearly ineffective in protecting from chromosome aberrations in bone marrow cells. Pharmavit is believed to be a promising agent for application to human populations exposed to the carcinogenic and genetic hazards of ionizing radiation.
Benova
D K
DK
National Centre of Radiobiology and Radiation Hygiene, Sofia, Bulgaria.
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects; D002869:Chromosome Aberrations; D005720:Gamma Rays; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009930:Organic Chemicals; D013093:Spermatogonia / Q000187:drug effects / Q000528:radiation effects*; D014178:Translocation, Genetic / Q000187:drug effects / Q000528:radiation effects; D014815:Vitamins / Q000494:pharmacology*
D016587:Antimutagenic Agents; D009930:Organic Chemicals; D014815:Vitamins; C077058:Pharmavit; D001205:Ascorbic Acid