Lectin-binding profile of plasmacytoid monocytes.
The lectin-binding profile of plasmacytoid monocytes, also known as plasmacytoid T cells, was studied in 18 axillary lymph nodes draining invasive breast carcinomas. The plasmacytoid monocytes bound fluorescein-conjugated lectins from Canavalia ensiformis (Con A), Phaseolus vulgaris (PHA-L), Arachis hypogaea (PNA), Ricinus communis (RCA I and II), and Triticum vulgaris (WGA), but no reaction was found with those from Dolichos biflorus (DBA) and Ulex europaeus (UEA I). Fluorescence was bright and the reactivity was distributed in a granular pattern in the cytoplasm of plasmacytoid monocytes, a staining pattern similar to that of monocytes and macrophages. B and T lymphocytes usually exhibited weak staining with the same lectins, and this was limited to the cell membrane. Plasmacytoid monocytes were originally thought to be closely related to the T-cell system. The results of recent immunocytologic studies and the lectin-binding profile of plasmacytoid monocytes observed in this study, however, suggest that these cells are related to the mononuclear phagocytic system.
Horst
H A
HA
Department of Internal Medicine II, University of Kiel, Germany.
Schumacher
U
U
Horny
H P
HP
Lennert
K
K
D015415:Biomarkers; D005260:Female; D006801:Humans; D037102:Lectins / Q000378:metabolism*; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology*; D008264:Macrophages / Q000378:metabolism; D009000:Monocytes / Q000166:cytology / Q000378:metabolism*
D015415:Biomarkers; D037102:Lectins