Bleomycin-detectable iron in the plasma of premature and full-term neonates.
The bleomycin assay measures non-transferrin-bound iron, able to catalyze free radical reactions, in human plasma. No bleomycin-detectable iron is present in plasma from healthy adults. However, plasma from 3/15 premature babies was positive in this assay. Plasma from 52 apparently-healthy term babies was analyzed and 11 were positive in the bleomycin assay. Hence not only some premature but also some full-term apparently-healthy babies may be at risk of severe oxidative damage.
Evans
P J
PJ
Department of Biochemistry, Kings College, London, UK.
Evans
R
R
Kovar
I Z
IZ
Holton
A F
AF
Halliwell
B
B
D001761:Bleomycin; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn / Q000097:blood*; D007234:Infant, Premature / Q000097:blood*; D007501:Iron / Q000097:blood*
D001761:Bleomycin; D007501:Iron