title: Early results of cryopreserved pulmonary allografts as aortic valve substitute.
abstract: Excellent clinical results with pulmonary autografts and experimental evidence that the pulmonary valve can withstand the higher stress in the systemic circulation led us to use the cryopreserved pulmonary allograft for aortic valve replacement. From September 1988 to March 1991, 45 consecutive patients (59.9 +/- 12.0 years, 25 men and 20 women) received a cryopreserved pulmonary allograft in the aortic position from our hospital based valve bank. All allografts were inserted freehand in the subcoronary position. There were 3 in-hospital deaths (7%) and 1 patient had severe valvular incompetence immediately postoperatively requiring reoperation after 4 weeks. Forty-one patients were followed at 3-6 month interval for 14.7 +/- 7.8 months (3-28 months) and valve performance was assessed routinely by means of color flow Doppler echocardiography: 34 patients (83%) had no or trivial aortic valve regurgitation. Valvular incompetence class II was present in 2 patients (5%) whereas 3 (7%) demonstrated class II-III. Severe aortic regurgitation (class III-IV) could be detected in 2 patients (5%). Both had to undergo reoperation 4 months and 15 months, respectively, postoperatively. Macroscopic and histological evaluation of the explanted valves demonstrated absence of significant degeneration. We assume that a mismatch in size between allograft and aortic annulus could have lead to dilatation of the allograft valve ring and consequently to valvular incompetence. Pulmonary cryopreserved allografts achieve acceptable short-term results which can be improved if initial technical problems can be avoided.
authors.affiliation: Department of Surgery I, General Hospital Linz, Austria.
authors.forename: R
authors.initials: R
authors.lastname: Mair
authors.forename: W
authors.initials: W
authors.lastname: Harringer
authors.forename: C
authors.initials: C
authors.lastname: Gross
authors.forename: P
authors.initials: P
authors.lastname: Hartl
authors.forename: G
authors.initials: G
authors.lastname: Wimmer-Greinecker
authors.forename: P
authors.initials: P
authors.lastname: Brücke
mesh_terms: D000328:Adult; D000368:Aged; D001021:Aortic Valve / Q000601:surgery*; D015925:Cryopreservation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009926:Organ Preservation; D011183:Postoperative Complications; D011664:Pulmonary Valve / Q000473:pathology / Q000637:transplantation*; D012086:Reoperation