[Evaluation of serum SC6 antigen using immunoradiometric assay for diagnosis of pancreatic cancer].
A solid-phase immunoradiometric sandwich assay for SC6 antigen was defined by a monoclonal antibody (SC6). The concentration of SC6 antigen in samples was determined by reference to a standard curve. The average intra- and interassay CV were 5.4% and 8.7% respectively. This antibody was found at low concentration in serum from 33 healthy individuals and the cutoff of normal upper limit of SC6 antigen was 41 U/ml. The level of serum SC6 antigen was assayed in 41 patients with pancreatic cancer, 95 with non-pancreatic carcinomas, and 48 with nonmalignant diseases. Frequency of elevated SC6 antigen level was highest in patients with gastrointestinal cancer, especially pancreatic cancer. The sensitivity and specificity were 70.7% and 84.3% for pancreatic cancer. The level in most cases of benign diseases was within upper normal limit. The results show that detection of SC6 antigen is valuable in the diagnosis of pancreatic cancer. It may be of help for detecting pancreatic cancer in its early stage.
Guo
X Z
XZ
Digestive Diseases Laboratory, Shenyang General Hospital of PLA.
Liu
M P
MP
Li
X X
XX
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D006801:Humans; D015592:Immunoradiometric Assay; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000276:immunology
D000911:Antibodies, Monoclonal; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor