title: Reduction of CSF monoamine metabolites in poststroke depression: a preliminary report.
abstract: Monoamine metabolites were measured in the cerebrospinal fluid (CSF) of depressed and nondepressed patients with acute stroke lesions and in nondepressed patients without stroke lesions. Depressed stroke patients had a significantly lower concentration of CSF 5-hydroxyindoleacetic acid (5-HIAA; a serotonin metabolite) than the other two groups. These findings suggest that poststroke depression may be mediated by serotonergic mechanisms.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: J B
authors.initials: JB
authors.lastname: Bryer
authors.forename: S E
authors.initials: SE
authors.lastname: Starkstein
authors.forename: V
authors.initials: V
authors.lastname: Votypka
authors.forename: R M
authors.initials: RM
authors.lastname: Parikh
authors.forename: T R
authors.initials: TR
authors.lastname: Price
authors.forename: R G
authors.initials: RG
authors.lastname: Robinson
mesh_terms: D000328:Adult; D000368:Aged; D002544:Cerebral Infarction / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000523:psychology; D003866:Depressive Disorder / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000523:psychology; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000523:psychology
chemical_list: D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D006719:Homovanillic Acid