Glutamate-gated ion channels in the brain. Genetic mechanism for generating molecular and functional diversity.
L-glutamate is the major excitatory neurotransmitter in the vertebrate central nervous system. Most cells are responsive to glutamate which activates cation channels with different pharmacological, kinetic, and ion permeability properties. These channels play important roles in neurotransmission, memory acquisition as well as acute and chronic disorders of the brain. The present report summarizes recent knowledge on AMPA (a-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid) receptors which mediate fast synaptic neurotransmission.
Sommer
B
B
Center for Molecular Biology, University of Heidelberg, Fed. Rep. of Germany.
Monyer
H
H
Wisden
W
W
Verdoorn
T A
TA
Burnashev
N
N
Sprengel
R
R
Sakmann
B
B
Seeburg
P H
PH
D000818:Animals; D001923:Brain Chemistry / Q000502:physiology; D005971:Glutamates / Q000502:physiology*; D018698:Glutamic Acid; D006801:Humans; D015640:Ion Channel Gating / Q000235:genetics / Q000502:physiology*; D007473:Ion Channels / Q000235:genetics / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000502:physiology*; D018091:Receptors, AMPA; D017981:Receptors, Neurotransmitter / Q000502:physiology
D005971:Glutamates; D007473:Ion Channels; D018377:Neurotransmitter Agents; D018091:Receptors, AMPA; D017981:Receptors, Neurotransmitter; D018698:Glutamic Acid