title: [Polymorphism of HLA class I loci HLA-A, -B, -C, in the Mandenka population from eastern Senegal].
abstract: A sample of 162 Mandenkalu from Eastern Senegal has been typed for three HLA class I loci: HLA-A, -B and -C. The Mandenka population presents a very high genetic variability with 15 alleles for locus A, 24 alleles for locus B, and at least 8 alleles for locus C. The calculated heterozygosities for the three loci A, B, and C are respectively 0.884, 0.944 and 0.829. The Mandenkalu allelic frequencies are close to that found in other sub-Saharan populations. They show, however, some peculiarities like the occurrence of the Bw 56 allele and the high frequencies of both B5 and B35.
authors.affiliation: Département d'Anthropologie et d'Ecologie, Université de Genève, Suisse.
authors.forename: P
authors.initials: P
authors.lastname: Dard
authors.forename: Y
authors.initials: Y
authors.lastname: Schreiber
authors.forename: L
authors.initials: L
authors.lastname: Excoffier
authors.forename: A
authors.initials: A
authors.lastname: Sanchez-Mazas
authors.forename: X
authors.initials: X
authors.lastname: Shi-Isaac
authors.forename: A
authors.initials: A
authors.lastname: Epelbouin
authors.forename: A
authors.initials: A
authors.lastname: Langaney
authors.forename: M
authors.initials: M
authors.lastname: Jeannet
mesh_terms: D000483:Alleles; D016009:Chi-Square Distribution; D005805:Genes, MHC Class I / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D015236:HLA-C Antigens / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D012675:Senegal / Q000453:epidemiology
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens