CD7 expression in malignant pleural mesothelioma.
CD7 antigen was found to be expressed on malignant mesothelioma arising from the right pleura in a 15-year-old girl not only by immunostaining using monoclonal antibodies, but also by Northern blot analysis. The level of expression in this tumor was comparable to those in T-cell lines, Jurkat and CCRF-CEM. Cytogenetic analysis of the tumor showed hypodiploidy (n = 43). CD7 has been regarded as one of the hematopoietic cell markers selectively expressed on the majority of T cells and multipotential stem cells. To our knowledge, this is the first report of a non-hematopoietic tumor expressing CD7.
Hibi
S
S
Division of Pediatrics, Children's Research Hospital, Kyoto.
Kataoka
Y
Y
Fujita
N
N
Okabe
H
H
Yoshikawa
K
K
Seto
M
M
Ueda
R
R
Imashuku
S
S
D000293:Adolescent; D000911:Antibodies, Monoclonal; D015703:Antigens, CD / Q000032:analysis*; D019011:Antigens, CD7; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis*; D015152:Blotting, Northern; D005260:Female; D006801:Humans; D008654:Mesothelioma / Q000188:drug therapy / Q000235:genetics / Q000276:immunology*; D010997:Pleural Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000276:immunology*
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D019011:Antigens, CD7; D000945:Antigens, Differentiation, T-Lymphocyte