title: Effect of gamma interferon on resolution of murine chlamydial genital infection.
abstract: Mice infected in the genital tract with the Chlamydia trachomatis agent of mouse pneumonitis were treated with monoclonal rat anti-gamma interferon (anti-IFN-gamma) antibody to determine whether IFN-gamma participated in the resolution of the infection. In two experiments, anti-IFN-gamma antibody treatment resulted in significantly prolonged infections. In support of these data, passive administration of recombinant IFN-gamma to chronically infected nu/nu mice was able to bring about resolution of the infection in some animals.
authors.affiliation: Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock 72205.
authors.forename: R G
authors.initials: RG
authors.lastname: Rank
authors.forename: K H
authors.initials: KH
authors.lastname: Ramsey
authors.forename: E A
authors.initials: EA
authors.lastname: Pack
authors.forename: D M
authors.initials: DM
authors.lastname: Williams
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D002690:Chlamydia Infections / Q000276:immunology*; D002692:Chlamydia trachomatis; D005260:Female; D005831:Genital Diseases, Female / Q000276:immunology*; D007371:Interferon-gamma / Q000494:pharmacology / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D011994:Recombinant Proteins
chemical_list: D000911:Antibodies, Monoclonal; D011994:Recombinant Proteins; D007371:Interferon-gamma