title: Enhancement of trinitrophenyl-specific humoral response to TNP proteins as the result of carrier chlorination.
abstract: Trinitrophenyl (TNP)-specific humoral response was tested after immunization with TNP-protein conjugates composed of either native proteins or proteins modified by chlorination. Significant enhancement of the hapten-specific response was observed as a result of carrier chlorination. This effect was dose dependent and affected mainly T-helper-cell activation. Since stimulated neutrophils chlorinate in vivo proteins, we propose that they take part in the induction phase of immune response by facilitation of antigen processing and/or presentation.
authors.affiliation: Department of Immunology, Copernicus School of Medicine, Cracow, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Marcinkiewicz
authors.forename: E
authors.initials: E
authors.lastname: Olszowska
authors.forename: S
authors.initials: S
authors.lastname: Olszowski
authors.forename: J M
authors.initials: JM
authors.lastname: Zgliczynski
mesh_terms: D000818:Animals; D000917:Antibody Formation; D006241:Haptens / Q000276:immunology; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D012710:Serum Albumin, Bovine / Q000276:immunology; D013997:Time Factors; D014301:Trinitrobenzenes / Q000276:immunology*; D010948:Viral Plaque Assay; D005719:gamma-Globulins / Q000276:immunology
chemical_list: D006241:Haptens; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D014301:Trinitrobenzenes; D005719:gamma-Globulins; D012710:Serum Albumin, Bovine