Non-random reassortment between the tripartite RNA genomes of La Crosse and snowshoe hare viruses.
The process of reassortment between the tripartite RNA genomes (segments designated L, M and S) of snowshoe hare and La Crosse bunyaviruses (Bunyaviridae) has been investigated by polymerase chain reaction analysis of greater than 250 progeny recovered at 72 h post-infection from dual wild-type virus infections involving high multiplicities (approximately 5) of each virus in a BHK-21 cell line. Statistical analysis of the data indicated that RNA segment reassortment was not random, and for these two viruses the data appeared to fit the hypothesis that there was a preference for homologous L-M and M-S associations among the progeny formed.
Urquidi
V
V
NERC Institute of Virology and Environmental Microbiology, Oxford, U.K.
Bishop
D H
DH
D000818:Animals; D001483:Base Sequence; D002478:Cells, Cultured; D006224:Cricetinae; D002141:Encephalitis Virus, California / Q000145:classification / Q000235:genetics*; D005814:Genes, Viral / Q000235:genetics*; D016679:Genome, Viral; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000235:genetics*; D011995:Recombination, Genetic
D012367:RNA, Viral