Emerging role of heat shock proteins in biology and medicine.
All cells, procaryotic and eucaryotic, respond to an elevation in temperature by increasing the synthesis of a family of proteins collectively known as heat shock proteins (HSPs). HSPs are among the most highly conserved and abundant proteins in nature. Studies on the regulation of the synthesis of HSPs have for several years shed light on the mechanisms regulating gene expression. The results from recent years, showing that HSPs play crucial roles in a wide variety of normal cellular processes, has made them an object of even broader interest, first to molecular and cellular biologists and later to specialists in various fields of medicine including oncology, immunology, infectious disease, autoimmunity, embryology, neurology and endocrinology. The aim of this review is to briefly summarize our present knowledge of the regulation of the heat shock response and the structure of the relevant gene products, HSPs. Moreover, some of the exciting associations between HSPs and various fields of medicine will be discussed.
Jäättelä
M
M
Department of Tumor Cell Biology, Fibiger Institute, Copenhagen, Denmark.
Wissing
D
D
D000818:Animals; D001327:Autoimmune Diseases / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D006360:Heat-Shock Proteins; D014409:Tumor Necrosis Factor-alpha