Repeated lindane exposure in the rat results in changes in spontaneous motor activity at 2 weeks post-exposure.
Male Wistar rats were given 25 doses of lindane, 10 mg/kg per day, 1 ml/kg p.o. in olive oil, or control vehicle. Two weeks after the last dose, the animals were assessed for modifications in spontaneous motor activity, plus-maze behavior, shuttle-box active avoidance acquisition, brain regional concentrations of biogenic amines and metabolites, and regional [35S]TBPS binding. Rats treated with lindane showed an increase in spontaneous motor activity. Although no additional behavioral or neurochemical modifications were found, the changes in activity observed at 2 weeks post-exposure further demonstrate the need to assess for long lasting neurobehavioral sequelae of repeated lindane exposure.
Llorens
J
J
Department of Neurochemistry, Consejo Superior de Investigaciones Cientificas (CSIC), Barcelona, Spain.
Tusell
J M
JM
Suñol
C
C
Rodríguez-Farré
E
E
D000284:Administration, Oral; D000818:Animals; D001679:Biogenic Amines / Q000032:analysis; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D001643:Bridged Bicyclo Compounds / Q000378:metabolism; D019086:Bridged Bicyclo Compounds, Heterocyclic; D002851:Chromatography, High Pressure Liquid; D003292:Convulsants / Q000378:metabolism; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D001679:Biogenic Amines; D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D003292:Convulsants; D001556:Hexachlorocyclohexane; C037476:tert-butylbicyclophosphorothionate