title: [Prevalence of hereditary pathologies in residents of the Kirov Province].
abstract: Medical-genetic study was carried out in the population of Kirov Province (population size about 120.000). 203 families with 334 affected with hereditary disorders were registered. The correctness of pathology classification for the inheritance type was confirmed by segregational analysis. The load of hereditary diseases in the population was: 1.25 +/- 0.06 for autosomal dominant, 1.37 +/- 0.07 for autosomal recessive and 0.22 +/- 0.06 for X-linked recessive disorders. It is suggested that variability in the values of the load of autosomal recessive disorders is determined to the large extent by genetic structure of the population.
authors.forename: R A
authors.initials: RA
authors.lastname: Mamedova
authors.forename: E K
authors.initials: EK
authors.lastname: Ginter
authors.forename: A N
authors.initials: AN
authors.lastname: Petrin
authors.forename: A V
authors.initials: AV
authors.lastname: Khvatova
authors.forename: O V
authors.initials: OV
authors.lastname: Khlebnikova
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Kadoshnikova
authors.forename: L K
authors.initials: LK
authors.lastname: Mikhaĭlova
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Prokhorov
authors.forename: G E
authors.initials: GE
authors.lastname: Rudenskaia
authors.forename: I D
authors.initials: ID
authors.lastname: Lukashova
mesh_terms: D005799:Genes, Dominant; D005808:Genes, Recessive; D030342:Genetic Diseases, Inborn / Q000453:epidemiology*; D008040:Genetic Linkage; D005828:Genetics, Population; D006801:Humans; D012426:Russia / Q000453:epidemiology; D014960:X Chromosome