Cerebellar norepinephrine infusions facilitate recovery after sensorimotor cortex injury.
This study reports the effects of norepinephrine infusions into cerebellum after unilateral sensorimotor cortex injury. The results demonstrate an immediate and permanent acceleration in motor recovery in awake rats infused with 150 micrograms norepinephrine into the cerebellum contralateral to a right sensorimotor cortex ablation. A vehicle infusion or infusion of norepinephrine into the ipsilateral cerebellum produced no beneficial effects on functional recovery.
Boyeson
M G
MG
Department of Rehabilitation Medicine, University of Wisconsin Medical School, Madison 53706.
Krobert
K A
KA
D000758:Anesthesia; D000818:Animals; D002531:Cerebellum; D007276:Injections, Intraventricular; D008297:Male; D009044:Motor Cortex / Q000293:injuries*; D009638:Norepinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013003:Somatosensory Cortex / Q000293:injuries*
D009638:Norepinephrine