[Short-term effect and the mechanism of radix Angelicae on pulmonary hypertension in chronic obstructive pulmonary disease].
The changes of hemodynamics, hemorheology and blood gas were investigated in 28 stable COPD patients with pulmonary hypertension after short-term treatment by Radix Angelicae. The level of TXA2, PGI2 were measured in 10 of the 28 patients before and after treatment. The results show that Radix Angelicae produced significant improvement on pulmonary hypertension, blood viscosity, hematocrit and the level of TXA2 decreased significantly. But the blood gas, blood pressure and the level of PGI2 remained unchanged in all of the patients.
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Research Department of Respiratory Diseases of Affilated Tongji, Hospital to Tongji, Medical University, Wuhan.
D001794:Blood Pressure / Q000187:drug effects*; D001809:Blood Viscosity / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology; D008173:Lung Diseases, Obstructive / Q000150:complications*; D011651:Pulmonary Artery / Q000187:drug effects; D013928:Thromboxane A2 / Q000097:blood
D004365:Drugs, Chinese Herbal; D013928:Thromboxane A2