[Efficacy of the use of a stabilized alpha2-macroglobulin concentrate in experimental burns].
The effectiveness of the use of a stabilized composition of alpha 2-macroglobulin concentrate obtained from fraction III of plasma proteins according to Cohn in burn disease in the experiment on guinea pigs was studied. Under the influence of intraabdominal administration for 4 days of alpha 2-macroglobulin concentrate with a stabilizer, healing of the burn wounds, normalization of a state of the animals occurred 2 times more rapidly than in control ones, activity of acid proteinases restored by day 5 (in control--by day 14) due to increase in activity of proteolytic enzyme inhibitors.
Perekhrestenko
P M
PM
Lositskaia
V M
VM
Lobunets
K A
KA
Voloshina
M S
MS
Sizov
V M
VM
Iakovenko
S B
SB
Mashchenko
V A
VA
Evtukh
V P
VP
D000818:Animals; D002056:Burns / Q000188:drug therapy*; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D007274:Injections, Intraperitoneal; D008297:Male; D013997:Time Factors; D000511:alpha-Macroglobulins / Q000737:chemistry / Q000627:therapeutic use*
D000511:alpha-Macroglobulins