Granulocyte colony stimulating factor in the management of chronic neutropenia.
OBJECTIVE
To report two cases of chronic neutropenic states successfully treated with granulocyte colony stimulating factor (G-CSF).


METHODS
A 23-year-old man with severe congenital cyclic neutropenia causing lifelong recurrent infections and consequent debilitation presented with intractable infected leg ulcers. A 56-year-old man with acquired idiopathic neutropenia presented with severe perianal infection and sepsis.


RESULTS
Both patients were successfully treated with recombinant G-CSF.


CONCLUSIONS
G-CSF is an agent with major clinical potential for the therapy of primary neutropenic states.
Marlton
P V
PV
Department of Haematology, Mater Misericordiae Hospitals, South Brisbane, QLD.
Wright
S J
SJ
Taylor
K M
KM
D000328:Adult; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000151:congenital / Q000628:therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor