Stability and blood compatibility of polylipid/Hb.
The Polylipid/Hb vesicle is a new artificial red cell (ARC) based on liposome-encapsulated Hb. Advantages are derived from the stabilized liposomal bilayer membranes, obtained by polymerization of 1,2-bis(2,4-octadecadienoyl)-sn-glycero-3-phospho choline (DODPC). Furthermore, blood compatibility in vitro are good.
Morizawa
K
K
Tsukuba Research Lab., Nippon Oil & Fats Co. Tsukuba, Japan.
Akama
K
K
Kawakami
Y
Y
Tsuchida
E
E
D001777:Blood Coagulation / Q000187:drug effects; D001802:Blood Substitutes / Q000008:administration & dosage* / Q000633:toxicity; D004355:Drug Stability; D004903:Erythrocyte Aggregation / Q000187:drug effects; D006454:Hemoglobins / Q000008:administration & dosage*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D008081:Liposomes; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D011108:Polymers
D001802:Blood Substitutes; D006454:Hemoglobins; D008081:Liposomes; D010975:Platelet Aggregation Inhibitors; D011108:Polymers