title: Trisomy 2 as the sole chromosomal abnormality in a hepatoblastoma.
abstract: Short-term cultures of a fine-needle aspirate from a hepatoblastoma were analyzed cytogenetically. Trisomy 2 was found as the sole abnormality, yielding the karyotype 47,XY, + 2/46,XY. Because trisomy for all or part of chromosome 2 has been described, although together with other aberrations, in seven of the 11 hepatoblastomas hitherto reported, the finding of + 2 as the only anomaly in the present case strongly indicates that additional chromosome 2 material is of pathogenetic significance in this tumor type.
authors.affiliation: Department of Clinical Genetics, University Hospital, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Bardi
authors.forename: B
authors.initials: B
authors.lastname: Johansson
authors.forename: N
authors.initials: N
authors.lastname: Pandis
authors.forename: S
authors.initials: S
authors.lastname: Heim
authors.forename: N
authors.initials: N
authors.lastname: Mandahl
authors.forename: A
authors.initials: A
authors.lastname: Békássy
authors.forename: I
authors.initials: I
authors.lastname: Hägerstrand
authors.forename: F
authors.initials: F
authors.lastname: Mitelman
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D002889:Chromosomes, Human, Pair 2; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D014314:Trisomy