title: Nitric oxide: a pathogenetic factor in autoimmunity.
abstract: Nitric oxide (NO) has been identified recently as a multifunctional mediator, produced by, and acting on, most cells of the body. Besides its function as endothelium-derived relaxing factor, as a neurotransmitter and as an immune defence molecule, evidence is accumulating that NO participates in inflammatory- and autoimmune-mediated tissue destruction. Modulation of NO synthesis and action represents a new approach to the treatment of inflammatory and autoimmune conditions.
authors.affiliation: Diabetes Research Institute, University of Düsseldorf, FRG.
authors.forename: H
authors.initials: H
authors.lastname: Kolb
authors.forename: V
authors.initials: V
authors.lastname: Kolb-Bachofen
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000037:antagonists & inhibitors / Q000145:classification / Q000378:metabolism; D000818:Animals; D001120:Arginine / Q000378:metabolism / Q000494:pharmacology; D015551:Autoimmunity / Q000502:physiology*; D002118:Calcium / Q000502:physiology; D002448:Cell Adhesion; D016923:Cell Death; D003921:Diabetes Mellitus, Experimental / Q000276:immunology / Q000473:pathology; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology; D004790:Enzyme Induction; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D007515:Islets of Langerhans / Q000473:pathology; D007527:Isoenzymes / Q000378:metabolism; D008262:Macrophage Activation; D051379:Mice; D009504:Neutrophils / Q000378:metabolism; D009569:Nitric Oxide / Q000276:immunology* / Q000633:toxicity; D019001:Nitric Oxide Synthase
chemical_list: D007527:Isoenzymes; D009569:Nitric Oxide; D001120:Arginine; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases; D002118:Calcium