Granulocyte-colony-stimulating factor enhances the circulating hematopoietic progenitors in lung cancer patients treated with cisplatin-containing regimens.
A phase II study examining the effects of human recombinant granulocyte-colony-stimulating factor (G-CSF) on the growth of colony-forming unit-granulocyte macrophage (CFU-GM) in the bone marrow and in the peripheral blood was performed in lung cancer patients treated with cisplatin-containing regimens. Treatment with G-CSF following chemotherapy significantly increased the absolute granulocyte count. No significant effect of G-CSF on either the platelet or the red blood cell count was observed. Treatment with G-CSF did not affect the CFU-GM levels in the bone marrow, but did have a significant effect on peripheral blood CFU-GM levels 14 days after initiation of chemotherapy (P less than 0.05). Four patients demonstrated a rebound increase in the level of peripheral blood CFU-GM during the first course of chemotherapy without G-CSF. In contrast, eight patients displayed increase in peripheral blood CFU-GM levels during the second course of chemotherapy with G-CSF treatment. These findings demonstrate that G-CSF is a potent stimulator of granulocyte proliferation as well as a potent agent for promoting transport of hematopoietic progenitors from the bone marrow into the peripheral blood.
Mukai
J
J
Third Department of Internal Medicine, University of Tokushima School of Medicine.
Shimizu
E
E
Ogura
T
T
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002945:Cisplatin / Q000008:administration & dosage*; D004341:Drug Evaluation; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects / Q000494:pharmacology*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D006098:Granulocytes / Q000166:cytology / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D008175:Lung Neoplasms / Q000097:blood* / Q000188:drug therapy; D008264:Macrophages / Q000166:cytology / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000188:drug therapy; D011994:Recombinant Proteins / Q000494:pharmacology; D013268:Stimulation, Chemical
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D002945:Cisplatin