title: The interactions of gamma delta T cells with extracellular matrix: receptor expression and utilization patterns.
abstract: Purified populations and clones of human gamma delta T cells were examined for their ability to interact with extracellular matrix (ECM) components. The stimulation of these cells with phorbol ester induced cellular adhesion for ECM. The adhesion structures for fibronectin and collagen were shown to be members of the CD29 integrin family. The expression patterns of beta 1, beta 2 and beta 3 integrins by these cells were examined. The receptor expression and utilization patterns suggest that alpha beta, gamma delta T cells and B cells have similar repertoires of adhesion structure.
authors.affiliation: Department of Internal Medicine, University of Manitoba, Winnipeg, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Wilkins
authors.forename: L
authors.initials: L
authors.lastname: Selin
authors.forename: S
authors.initials: S
authors.lastname: Stewart
authors.forename: K
authors.initials: K
authors.lastname: Sivananthan
authors.forename: D
authors.initials: D
authors.lastname: Stupack
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D002999:Clone Cells; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D006801:Humans; D019012:Integrin beta1; D016023:Integrins / Q000032:analysis; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000032:analysis; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D013601:T-Lymphocytes / Q000276:immunology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D015703:Antigens, CD; D016326:Extracellular Matrix Proteins; D019012:Integrin beta1; D016023:Integrins; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta; D013755:Tetradecanoylphorbol Acetate