[Lichenoid eruptions after gold therapy. Report of two cases].
Lichenoid eruptions appearing in two women receiving chrysotherapy (Solganal B oleosum R) a described. The morphological diagnosis, distribution of skin eruptions, histological and immunological features and monoclonal antibodies (Leu 4, Leu 2A and Leu 3A) against several cell surface markers were studied. Individual lesions were not distinguishable from idiopathic lichen planus, with some features typical for gold lichenoid eruptions: hyperpigmentation, psoriasiform eruptions, and hair loss. Histopathological and immunological examination of biopsy specimens with monoclonal antibodies generally confirms clinical impressions. The authors suggest similar pathogenetic mechanisms in the development of idiopathic lichen planus and of lichenoid eruptions after gold therapy.
Lasarowa
A Z
AZ
Institut für Dermatologie und Venerologie, Medizinischen Akademie Sofia, Bulgarien.
Tsankov
N K
NK
Stoimenov
A P
AP
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001284:Atrophy; D006051:Aurothioglucose / Q000008:administration & dosage / Q000009:adverse effects*; D003875:Drug Eruptions / Q000473:pathology*; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008010:Lichen Planus / Q000139:chemically induced* / Q000473:pathology; D012867:Skin / Q000473:pathology
D006051:Aurothioglucose