title: Deletions of 17p and p53 mutations in preneoplastic lesions of the lung.
abstract: Cytogenetic and p53 mutation analysis in two cases of severe dysplasia of the bronchial epithelium in lung cancer patients and p53 immunostaining in a third one are reported. The finding of both chromosomal deletions of 17p and p53 mutation indicates that these changes may take place early in the process of lung carcinogenesis.
authors.affiliation: Division of Experimental Oncology A, Istituto Nazionale Tumori, Milano, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Sozzi
authors.forename: M
authors.initials: M
authors.lastname: Miozzo
authors.forename: R
authors.initials: R
authors.lastname: Donghi
authors.forename: S
authors.initials: S
authors.lastname: Pilotti
authors.forename: C T
authors.initials: CT
authors.lastname: Cariani
authors.forename: U
authors.initials: U
authors.lastname: Pastorino
authors.forename: G
authors.initials: G
authors.lastname: Della Porta
authors.forename: M A
authors.initials: MA
authors.lastname: Pierotti
mesh_terms: D001483:Base Sequence; D002278:Carcinoma in Situ / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002872:Chromosome Deletion; D002886:Chromosomes, Human, Pair 17; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008969:Molecular Sequence Data; D011230:Precancerous Conditions / Q000235:genetics*