Clinically normal skin becomes sclerodermatous when transplanted into a sclerodermatous area.
A 56-year-old female with systemic sclerosis developed sclerodermatous change in clinically normal forearm skin 10 months after this was transplanted to the tip of her right index finger. This observation implicates local factors in the pathogenesis of the disease.
Herrick
A L
AL
Rheumatic Diseases Center, University of Manchester.
Marcuson
R
R
Freemont
A J
AJ
Jayson
M I
MI
D005260:Female; D006801:Humans; D008833:Microcirculation; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000473:pathology* / Q000503:physiopathology; D012867:Skin / Q000098:blood supply / Q000473:pathology*; D016038:Skin Transplantation / Q000473:pathology*