[Fusarin C induced esophageal and forestomach carcinoma in mice and rats].
Fusarium moniliforme, a fungus of established carcinogenic potential, is one of the most common fungal contaminants of maize, millet and other grains in Linxian, China, a high-risk county for human esophageal cancer. Fusarin C, a major product of F. moniliforme grown on corn in the laboratory, is mutagenic in Salmonella tester strains and in V79 cells. Fusarin C treated rat esophageal epithelial cell line showed several characteristics of malignant transformations including the growth in nude mice. The present work demonstrated that Fusarin C can induce esophageal and forestomach carcinoma in DBA mice and Wistar rats thus further substantiating the carcinogenicity of this mycotoxin.
Li
M X
MX
Cancer Institute, Chinese Academy of Medical Sciences, Beijing.
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D004938:Esophageal Neoplasms / Q000139:chemically induced*; D005260:Female; D006965:Hyperplasia / Q000139:chemically induced; D051379:Mice; D008811:Mice, Inbred DBA; D010212:Papilloma / Q000139:chemically induced; D011090:Polyenes; D011230:Precancerous Conditions / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains; D013274:Stomach Neoplasms / Q000139:chemically induced*
D011090:Polyenes; C041403:fusarin C