title: Implantable programmable insulin pumps for the treatment of diabetes.
abstract: Implantable programmable pump systems for insulin delivery to the peritoneal cavity or for intravenous insulin delivery have been recently developed. Thirty-one pumps were implanted in 25 patients between 1987 and 1991. At this writing, 76% of patients had functioning pumps. Ninety-two percent of pumps were functioning at 1 year; 89% at 2 years; and 50% at 3 years. No life-threatening complications, either surgical or metabolic, developed. However, 18 patients required 23 outpatient procedures for maintenance of pump function or for pump removal. Metabolic improvement was evidenced by mean and standard deviation of blood glucose levels and by glycosylated hemoglobin levels.
authors.affiliation: Department of Surgery, University of California-Irvine, Orange.
authors.forename: K
authors.initials: K
authors.lastname: Waxman
authors.forename: D
authors.initials: D
authors.lastname: Turner
authors.forename: S T
authors.initials: ST
authors.lastname: Nguyen
authors.forename: J L
authors.initials: JL
authors.lastname: Selam
authors.forename: M A
authors.initials: MA
authors.lastname: Charles
mesh_terms: D000009:Abdominal Muscles / Q000601:surgery; D000273:Adipose Tissue / Q000601:surgery; D001786:Blood Glucose / Q000032:analysis; D002404:Catheterization / Q000295:instrumentation; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy* / Q000601:surgery; D004867:Equipment Design; D004868:Equipment Failure; D000071938:Fasciotomy; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D015918:Infusion Pumps, Implantable; D007262:Infusions, Intravenous / Q000295:instrumentation; D007274:Injections, Intraperitoneal; D007328:Insulin / Q000008:administration & dosage; D007332:Insulin Infusion Systems; D011095:Polyethylenes; D012449:Safety; D013350:Subclavian Vein; D013997:Time Factors; D014025:Titanium
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin; D011095:Polyethylenes; D014025:Titanium