[Polymorphism of HLA class I loci HLA-A, -B, -C, in the Mandenka population from eastern Senegal].
A sample of 162 Mandenkalu from Eastern Senegal has been typed for three HLA class I loci: HLA-A, -B and -C. The Mandenka population presents a very high genetic variability with 15 alleles for locus A, 24 alleles for locus B, and at least 8 alleles for locus C. The calculated heterozygosities for the three loci A, B, and C are respectively 0.884, 0.944 and 0.829. The Mandenkalu allelic frequencies are close to that found in other sub-Saharan populations. They show, however, some peculiarities like the occurrence of the Bw 56 allele and the high frequencies of both B5 and B35.
Dard
P
P
Département d'Anthropologie et d'Ecologie, Université de Genève, Suisse.
Schreiber
Y
Y
Excoffier
L
L
Sanchez-Mazas
A
A
Shi-Isaac
X
X
Epelbouin
A
A
Langaney
A
A
Jeannet
M
M
D000483:Alleles; D016009:Chi-Square Distribution; D005805:Genes, MHC Class I / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D015236:HLA-C Antigens / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D012675:Senegal / Q000453:epidemiology
D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens