title: Recovery of cognitive functions after anaesthesia with desflurane or isoflurane and nitrous oxide.
abstract: We studied recovery in 25 adult patients, ASA I, undergoing elective orthopaedic procedures after anaesthesia with 0.65 MAC desflurane (n = 16) or isoflurane (n = 9) with 60% nitrous oxide in oxygen. Early emergence from anaesthesia was assessed in the operating room by measuring time to spontaneous movement, cough, response to painful pinch, tracheal extubation, opening of the eyes and stating correct age, name and body parts. The return of cognitive functions in the late recovery phase was assessed in the post-anaesthesia care unit (PACU) by post-anaesthesia recovery scores (PARS), the Trieger dot test (TDT), and the digit substitution test (DST). In the early recovery phase, time to tracheal extubation, opening eyes, telling correct name, age and body parts occurred significantly faster in the desflurane group than in the isoflurane group (P < 0.05). The mean "triple orientation" time (to name, age, body parts) was 10.9 (SEM 0.9) min for desflurane, compared with 18.6 (2.5) min for isoflurane (P < 0.01). In the late recovery phase, desflurane patients had significantly greater PARS, more correct responses to the DST and fewer error responses to the TDT. Recovery times were not increased by increased duration of desflurane anaesthesia. The desflurane patients showed no delirium, minimal sedation and less shivering during the entire postoperative course. We conclude that desflurane anaesthesia was superior to isoflurane anaesthesia, not only in emergence, but also in the recovery of cognitive functions.
authors.affiliation: Department of Anesthesiology, Harbor-UCLA Medical Center, Torrance 90509.
authors.forename: S K
authors.initials: SK
authors.lastname: Tsai
authors.forename: C
authors.initials: C
authors.lastname: Lee
authors.forename: W F
authors.initials: WF
authors.lastname: Kwan
authors.forename: B J
authors.initials: BJ
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000762:Anesthesia Recovery Period; D000777:Anesthetics / Q000494:pharmacology*; D003071:Cognition / Q000187:drug effects*; D003243:Consciousness / Q000187:drug effects; D000077335:Desflurane; D006801:Humans; D007530:Isoflurane / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D009609:Nitrous Oxide / Q000494:pharmacology; D013997:Time Factors
chemical_list: D000777:Anesthetics; D000077335:Desflurane; D007530:Isoflurane; D009609:Nitrous Oxide