Serum granulocyte colony-stimulating factor in patients with repeated infections.
We have already reported significant elevation of serum granulocyte colony-stimulating factor (G-CSF) in the acute phase of infection. In this study, we compared the responses to infection between patients with frequently repeated infection (repeaters) and others (non-repeaters). We examined the clinical data and serum G-CSF levels in 48 patients with acute infections. Serum G-CSF levels were significantly lower in repeaters than in non-repeaters (197.7 +/- 370.0 vs. 1014.1 +/- 924.4 pg/ml. P less than 0.001). There were no significant differences in age, serum total protein, or cholinesterase between the groups, but serum albumin was significantly lower in repeaters than in non-repeaters (2.87 +/- 0.5 vs. 3.31 +/- 0.4 g/dl. P less than 0.005). It is suggested that administration of recombinant G-CSF may be useful for patients with repeated infections.
Kawakami
M
M
Department of Hematology, Tokyo Metropolitan Geriatric Hospital, Japan.
Tsutsumi
H
H
Kumakawa
T
T
Hirai
M
M
Kurosawa
S
S
Mori
M
M
Fukushima
M
M
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood*; D006801:Humans; D008297:Male; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000097:blood*; D012709:Serum Albumin / Q000032:analysis; D014552:Urinary Tract Infections / Q000097:blood*
D012709:Serum Albumin; D016179:Granulocyte Colony-Stimulating Factor