title: The human squamous cervical carcinoma cell line, HOG-1, is responsive to steroid hormones.
abstract: Growth of the human squamous cervical carcinoma cell line, HOG-I, was stimulated in response to oestradiol in serum-containing and chemically defined medium. The oestradiol-stimulated growth could be inhibited by 4-OH tamoxifen, progesterone and medroxyprogesterone acetate; the last 2 compounds also inhibited basal cell growth in serum-containing and chemically defined media. The data are consistent with the sensitivity of human squamous cervical cancer to sex-steroid hormones and suggest that endocrine therapies may be of benefit in this disease.
authors.affiliation: Institute of Obstetrics and Gynaecology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
authors.forename: J O
authors.initials: JO
authors.lastname: White
authors.forename: R N
authors.initials: RN
authors.lastname: Jones
authors.forename: J D
authors.initials: JD
authors.lastname: Croxtall
authors.forename: R P
authors.initials: RP
authors.lastname: Gleeson
authors.forename: T
authors.initials: T
authors.lastname: Krausz
authors.forename: S
authors.initials: S
authors.lastname: Pervez
authors.forename: A
authors.initials: A
authors.lastname: Jamil
authors.forename: L
authors.initials: L
authors.lastname: Guida
authors.forename: J E
authors.initials: JE
authors.lastname: Beesley
authors.forename: W P
authors.initials: WP
authors.lastname: Soutter
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000188:drug therapy* / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D003470:Culture Media; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008525:Medroxyprogesterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D017258:Medroxyprogesterone Acetate; D013629:Tamoxifen / Q000031:analogs & derivatives* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D002583:Uterine Cervical Neoplasms / Q000737:chemistry / Q000188:drug therapy* / Q000473:pathology
chemical_list: D003470:Culture Media; D013629:Tamoxifen; C016601:afimoxifene; D004958:Estradiol; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone