Effect of Casodex on sleep-related erections in patients with advanced prostate cancer.
Sleep-related erections in 5 patients with stage T3N0M0 prostate cancer treated with a new nonsteroidal antiandrogen, Casodex, were evaluated with continuous monitoring of penile tumescence and rigidity on multiple nights. Mean serum luteinizing hormone levels were 7.2 +/- 1.2 IU/l. before therapy and increased to 14 +/- 3.6 IU/l. after 6 months of therapy. Serum testosterone and estradiol levels also increased from a basal level of 5.05 +/- 1.9 ng./ml. and 102 +/- 18 pmol./l., respectively, to 8.04 +/- 1.32 ng./ml. and 175 +/- 20 pmol./l., respectively, after 6 months of therapy. No significant modifications in regard to number of nocturnal penile tumescence episodes, maximum penile circumference and total rigidity time were found before and after therapy. Only 1 patient reported a decrease in sexual drive and libido. All patients presented with stable disease (National Prostatic Cancer Treatment Group criteria) and an unmodified performance status (Eastern Cooperative Oncology Group) after 6 months. Pure antiandrogen therapy did not seem to interfere significantly with the erectile capability of men with prostate cancer.
Migliari
R
R
Clinica Urologica, Università di Cagliari, Italy.
Muscas
G
G
Usai
E
E
D000135:Acid Phosphatase / Q000097:blood; D000726:Androgen Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D000813:Anilides / Q000494:pharmacology / Q000627:therapeutic use*; D000951:Antigens, Neoplasm / Q000097:blood; D004958:Estradiol / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D009570:Nitriles; D010410:Penile Erection / Q000187:drug effects*; D017430:Prostate-Specific Antigen; D011471:Prostatic Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D012890:Sleep; D013739:Testosterone / Q000097:blood; D014105:Tosyl Compounds
D000726:Androgen Antagonists; D000813:Anilides; D000951:Antigens, Neoplasm; D009570:Nitriles; D014105:Tosyl Compounds; D013739:Testosterone; D004958:Estradiol; C053541:bicalutamide; D000135:Acid Phosphatase; D017430:Prostate-Specific Antigen