Karyotype evolution in a patient with biphenotypic neonatal leukemia.
We present the case of a 4-day-old boy with acute lymphoblastic leukemia showing at onset a karyotype 46,XY,t(4;11)(q21;q23). At relapse an additional change, add(2), was present. Molecular analysis showed the same immunoglobulin rearrangement both at onset and at relapse, but immunohistochemical analysis revealed some cells having myeloid features. A continuous cell line derived from the leukemic blasts of the patient presented typical monoblastic features.
Fugazza
G
G
Department of Biology and Genetics, University of Genova, Italy.
Basso
G
G
Sessarego
M
M
Haupt
R
R
Comelli
A
A
Roncella
S
S
Negri
D
D
Sansone
R
R
D002460:Cell Line; D002880:Chromosomes, Human, Pair 11; D002894:Chromosomes, Human, Pair 4; D015321:Gene Rearrangement; D006801:Humans; D016130:Immunophenotyping; D007231:Infant, Newborn; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000151:congenital* / Q000235:genetics; D007951:Leukemia, Myeloid / Q000151:congenital* / Q000235:genetics; D008297:Male; D014178:Translocation, Genetic