Beta/A4 deposits and their relationship to senile plaques in Alzheimer's disease.
The density and spatial pattern of immunostained beta/A4 deposits and mature senile plaques (SP) stained by the Glees method were compared in Alzheimer's diseased brain. Thirty-seven percent of the variance in Glees SP density in a tissue could be explained by beta/A4. Both lesions were clustered with the beta/A4 clusters often larger than the Glees SP clusters. Beta/A4 and Glees SP cluster size were not correlated in a tissue. The size of Glees SP clusters was positively correlated with SP density but no correlation could be detected for beta/A4. Hence, the density and spatial pattern of beta/A4 deposits in most tissues did not predict the development of Glees SP.
Armstrong
R A
RA
Department of Vision Sciences, Aston University, Birmingham, UK.
Myers
D
D
D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D012044:Regression Analysis; D013194:Staining and Labeling
D009419:Nerve Tissue Proteins