Biochemical changes in arthritic rats under the influence of vitamin E.
Two phases of adjuvant arthritis, acute phase (4 days after adjuvant inoculation) and chronic phase (21 and 29 days after adjuvant inoculation) were studied in male rats. The effect of administration of vitamin E in a daily oral dose of 147 mg/kg body wt. for one week against these phases of arthritis were demonstrated before and after adjuvant inoculation. Results showed that administration of the vitamin before and after adjuvant inoculation increased the lowered serum-SH group in arthritic rats so that their level was restored to pre-arthritic values especially in chronic treated group. Meanwhile, these treatments produced no change in the increased level of blood GSH or erythrocyte SOD activity of arthritic rats. The results showed also that administration of vitamin E before adjuvant inoculation increased significantly the level of alpha 2-M while it did not alter the increased serum Cp in acute phase. However, administration of the vitamin after adjuvant inoculation failed to exert any change in these parameters. In the meantime, these treatments tended to increase the lowered A/G of arthritic rats in different phases especially in acute one. These observations suggest that antioxidants such as vitamin E may be beneficial for arthritis.
Kheir-Eldin
A A
AA
Department of Biochemistry, Faculty of Pharmacy, Cairo University, Egypt.
Hamdy
M A
MA
Motawi
T K
TK
Shaheen
A A
AA
Abd el Gawad
H M
HM
D000818:Animals; D001169:Arthritis, Experimental / Q000378:metabolism*; D002570:Ceruloplasmin / Q000378:metabolism; D004912:Erythrocytes / Q000201:enzymology; D005978:Glutathione / Q000097:blood; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000097:blood; D014810:Vitamin E / Q000494:pharmacology*; D000511:alpha-Macroglobulins / Q000378:metabolism
D000511:alpha-Macroglobulins; D014810:Vitamin E; D013482:Superoxide Dismutase; D002570:Ceruloplasmin; D005978:Glutathione