title: Immune-mediated disease as a risk factor for canine lymphoma.
abstract: BACKGROUND
  Autoimmune diseases and neoplasia have been associated as occurring simultaneously in individuals. This study evaluated the association between the simultaneous occurrence of canine lymphoma and various immune-mediated diseases.
  
  
  METHODS
  The Veterinary Medical Data Program, a national disease data registry for veterinary schools, was examined. The following immune-mediated disease categories were evaluated: lupus disorders, pemphigus disorders, autoimmune polyarthritis, immune-mediated hemolytic anemia, and immune-mediated thrombocytopenia. Odds ratios with 99% confidence intervals were calculated for the occurrence of lymphoma and each of the immune-mediated disorder categories.
  
  
  RESULTS
  Only dogs with immune-mediated thrombocytopenia had a statistically significantly increased odds ratio (5.61; 99% confidence interval, 4.16-7.57) for the occurrence of lymphoma versus the general population. This association still was observed for immune-mediated thrombocytopenia when stratified by age, sex, and neutering status.
  
  
  CONCLUSIONS
  Dogs with immune-mediated thrombocytopenia had a greater occurrence of lymphoma than dogs without immune-mediated thrombocytopenia.
authors.affiliation: Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706.
authors.forename: E T
authors.initials: ET
authors.lastname: Keller
mesh_terms: D000367:Age Factors; D000818:Animals; D001327:Autoimmune Diseases / Q000453:epidemiology / Q000662:veterinary*; D002369:Castration; D004283:Dog Diseases / Q000453:epidemiology*; D004285:Dogs; D005260:Female; D008223:Lymphoma / Q000453:epidemiology / Q000662:veterinary*; D008297:Male; D016017:Odds Ratio; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D013921:Thrombocytopenia / Q000453:epidemiology / Q000662:veterinary; D014481:United States / Q000453:epidemiology