title: Tiopronine-induced reduction of rheumatoid factor functional affinity and asialylated IgG in patients with rheumatoid arthritis.
abstract: Serum and synovial fluid (SF) from 16 rheumatoid arthritis patients were evaluated before and after a 2-month treatment with tiopronine (TP). The levels of rheumatoid factor (RF) declined, as did the functional affinity of the remaining RF (p less than 0.01 in serum and p less than 0.05 in SF). Concomitant restoration of the sialylation of IgG was observed (p less than 0.05 in serum and SF). Following an initial increase, a significant reduction was observed in the level of soluble interleukin-2 receptors in serum (p less than 0.05) and SF (p less than 0.05) after treatment with TP.
authors.affiliation: Laboratory of Immunology, Brest University Medical School Hospital, France.
authors.forename: P
authors.initials: P
authors.lastname: Youinou
authors.forename: J
authors.initials: J
authors.lastname: Keusch
authors.forename: R
authors.initials: R
authors.lastname: Casburn-Budd
authors.forename: L
authors.initials: L
authors.lastname: Paolozzi
authors.forename: A
authors.initials: A
authors.lastname: Lamour
authors.forename: P
authors.initials: P
authors.lastname: Le Goff
authors.forename: B
authors.initials: B
authors.lastname: Bendaoud
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000032:analysis; D012217:Rheumatoid Factor / Q000032:analysis / Q000502:physiology*; D013582:Synovial Fluid / Q000737:chemistry; D013601:T-Lymphocytes / Q000187:drug effects / Q000648:ultrastructure; D008625:Tiopronin / Q000494:pharmacology*
chemical_list: D007074:Immunoglobulin G; D015375:Receptors, Interleukin-2; D012217:Rheumatoid Factor; D008625:Tiopronin