On the induction of umu gene expression in Salmonella typhimurium strain TA1535/pSK1002 by some nitrofurans.
Several nitrofurans were found to induce umu gene expression in Salmonella typhimurium TA1535/pSK1002 as defined on the basis of at least a 2-fold increase of beta-galactosidase activity over the background level. beta-Galactosidase activity increased with increasing concentrations of the chemical, attained a maximum at a concentration which was different for different nitrofurans used, and then gradually decreased with a further increase of the nitrofuran concentration. The umu gene expression test revealed that the genotoxic activity was highest for furazolidone and lowest for 5-nitro-2-furaldehyde.
Pal
A K
AK
Biophysics Division, Saha Institute of Nuclear Physics, Calcutta, India.
Rahman
M S
MS
Chatterjee
S N
SN
D001386:Azides / Q000633:toxicity; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects*; D005798:Genes, Bacterial; D008769:Methylnitronitrosoguanidine / Q000633:toxicity; D009153:Mutagens / Q000633:toxicity*; D009581:Nitrofurans / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000235:genetics*; D019810:Sodium Azide; D001616:beta-Galactosidase / Q000378:metabolism
D001386:Azides; D009153:Mutagens; D009581:Nitrofurans; D008769:Methylnitronitrosoguanidine; D019810:Sodium Azide; D001616:beta-Galactosidase