title: Inducible protective processes in animal systems. III. Adaptive response of meiotic cells of the grasshopper, Poecilocerus pictus, to a low dose of ethyl methanesulfonate.
abstract: Meiotic cells of Poecilocerus pictus exposed to a low dose of 0.03 M of ethyl methanesulfonate (EMS) were found to be resistant to the induction of chromosomal anomalies by a subsequent challenge dose (0.12 M) of the same mutagen as compared to cells that were not pre-exposed. They responded with a significantly reduced incidence of chromosomal anomalies in metaphase I and II and anaphase I and II. These results indicate the presence of an inducible chromosomal repair mechanism in meiotic cells of P. pictus. The incidence of chromosome damage was found to be less when the time lag between the conditioning and challenging doses was reduced, suggesting that under the conditions tested, the efficacy of repair enzymes gradually decreases as the time between the two doses increases.
authors.affiliation: Department of Studies in Zoology, University of Mysore, India.
authors.forename: R
authors.initials: R
authors.lastname: Mahmood
authors.forename: V
authors.initials: V
authors.lastname: Vasudev
mesh_terms: D000220:Adaptation, Biological / Q000187:drug effects; D000818:Animals; D016009:Chi-Square Distribution; D002869:Chromosome Aberrations; D011088:DNA Ligases / Q000235:genetics; D004260:DNA Repair / Q000187:drug effects*; D004790:Enzyme Induction; D005020:Ethyl Methanesulfonate / Q000633:toxicity*; D006110:Grasshoppers / Q000235:genetics*; D008297:Male; D008540:Meiosis / Q000187:drug effects*; D013997:Time Factors
chemical_list: D005020:Ethyl Methanesulfonate; D011088:DNA Ligases