Simultaneous occurrence of primary sclerosing cholangitis and autoimmune chronic active hepatitis in a patient with ulcerative colitis.
The simultaneous occurrence of PSC and autoimmune CAH in a patient with ulcerative colitis is described. Although each disease is a well documented complication of UC, their combination has never been reported. The diagnosis of PSC was based on typical findings on ERCP and liver biopsy and that of CAH was based on typical findings on liver biopsy supported by HLA typings and a remarkable response to a combination of glucocorticoids and azathioprine. The difficulties in establishing the diagnosis and the management of such patients are discussed.
Rabinovitz
M
M
Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania 15261.
Demetris
A J
AJ
Bou-Abboud
C F
CF
Van Thiel
D H
DH
D000328:Adult; D001327:Autoimmune Diseases / Q000209:etiology* / Q000473:pathology; D001706:Biopsy; D002760:Cholangiopancreatography, Endoscopic Retrograde; D015209:Cholangitis, Sclerosing / Q000209:etiology* / Q000473:pathology; D003093:Colitis, Ulcerative / Q000150:complications*; D006521:Hepatitis, Chronic / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male