[Influence of dietary selenium level on immune function of rats with esophageal tumors induced by methylbenzylnitrosamine (NMBzA)].
The influence of dietary selenium of the incidence of esophageal tumor induced by NMBzA and the immune function during carcinogenesis were studied in rats fed with Torula yeast diet and survived for 18 weeks. The incidences of esophageal tumors were statistically not significant among rats on normal, high and low selenium intake (P greater than 0.05). The level of plaque forming cells (PFC), delayed type hypersensitivity (DTH), natural killer cell activity (NK) were significantly higher in the high selenium diet group than those of the low selenium diet group (P less than 0.05). The authors believe that the modulation of dietary selenium can alter the immune function of animals during carcinogenesis but the anticarcinogenic effect of selenium still needs further study.
Zhu
M
M
Xinjiang Medical College, Urumchi.
D000818:Animals; D002273:Carcinogens; D004128:Dimethylnitrosamine / Q000031:analogs & derivatives; D004938:Esophageal Neoplasms / Q000139:chemically induced / Q000276:immunology* / Q000517:prevention & control; D006462:Hemolytic Plaque Technique; D006968:Hypersensitivity, Delayed; D007694:Killer Cells, Natural / Q000276:immunology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012643:Selenium / Q000627:therapeutic use*
D002273:Carcinogens; C014707:nitrosobenzylmethylamine; D012643:Selenium; D004128:Dimethylnitrosamine