[Current data on GM-CSF (Granulocyte-Macrophage Colony Stimulating Factor) in acute myeloid leukemia].
GM-CSF (Granulocyte-Macrophage Colony Stimulating Factor) activates neutrophil, eosinophil, granular, and macrophage precursors through binding to specific receptors. GM-CSF receptor is a member of the "cytokine receptor superfamily", which displays a particular transmembrane structure. It is expressed in small amounts on normal mature blood or medullary cells, with a high affinity. On acute myeloid leukemia blasts (18 patients), our results agree with the review of the literature: GM-CSF receptors are in small amounts, of two types (high and low affinity), with no relation to the FAB classification of leukemias.
de Gentile
A
A
Service de médecine nucléaire, hôpital Saint-Louis, Paris, France.
Schlageter
M H
MH
Krawice
I
I
Dombret
H
H
Najean
Y
Y
Chomienne
C
C
Toubert
M E
ME
D003115:Colony-Stimulating Factors / Q000502:physiology*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood*; D016184:Receptors, Colony-Stimulating Factor / Q000032:analysis / Q000502:physiology
D003115:Colony-Stimulating Factors; D016184:Receptors, Colony-Stimulating Factor