[Resistance and capacity function of blood vessels of the brain during activation of its cholinergic mechanisms].
Blood from the cat donor was perfused into the haemodynamically isolated cat brain. The changes of the vascular resistance and their capacity during the pharmacological activity of the endogenic cholinergic mechanism on the introduction of phosphacol into the bloodstream were investigated. Research has shown that the reduction of the activity of cholinergics leads to a decrease in pressure in the arteries of the brain and to an increase of the intercellular fluid absorption, caused by the neurogenic cholinergic influences. The possibility of a mediator realisation of the cholinergic influences on the brain vessels is discussed.
Pugovkin
A P
AP
Artem'eva
A I
AI
Lazarev
S G
SG
D000109:Acetylcholine / Q000502:physiology*; D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology / Q000502:physiology*; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D002802:Cholinesterases / Q000097:blood / Q000378:metabolism; D004789:Enzyme Activation; D006651:Histocytochemistry; D066298:In Vitro Techniques; D013053:Spectrophotometry; D014655:Vascular Resistance
D002800:Cholinesterase Inhibitors; D000110:Acetylcholinesterase; D002802:Cholinesterases; D000109:Acetylcholine