Circulating endothelin is not extracted by the pulmonary circulation in man.
To determine whether endothelin is extracted from plasma during passage through the pulmonary circulation, we measured its concentration at several points, including the pulmonary artery and the left superior pulmonary vein in seven patients undergoing cardiac surgery. Endothelin concentrations were very similar at all sites sampled. In patients undergoing coronary artery bypass grafting, there is no net pulmonary clearance of endothelin.
Ray
S G
SG
Department of Cardiology, Western Infirmary, Glasgow, Scotland.
McMurray
J J
JJ
Morton
J J
JJ
Dargie
H J
HJ
D000328:Adult; D000787:Angina Pectoris / Q000097:blood / Q000601:surgery; D001026:Coronary Artery Bypass; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011651:Pulmonary Artery; D011652:Pulmonary Circulation; D011667:Pulmonary Veins; D014684:Venae Cavae
D016232:Endothelins