Aluminium hydroxide uptake in the stomach and in the intestine of the rat: a histochemical study.
Using the histochemical stains aluminon, solochrome azurine and solochrome cyanine, intracellular binding of aluminium was examined in the mucosa of the stomach, duodenum, jejunum and ileum of adult rats. A first group of rats (n = 42) was sacrificed 1, 3, 6, 12, 24, 48 and 96 h after a single (300 mg x kg-1) oral administration of aluminium hydroxide. A second group of animals (n = 30) received daily the same dose of Al(OH)3 and was euthanatized after 3, 4, 5, 6 and 7 days of treatment. Aluminium deposits occurred only in the antral glands of the stomach and in rats treated for at least 3 days. The reactive deposits are located in the cytoplasm of the upper glandular cells and in the lumen of the antral glands. These results suggest that aluminium is absorbed through the antral mucosa and may be re-excreted through the glandular mucus flow into the digestive lumen where it will be absorbed again. We hypothesize that the metal could act as a delayed-effect drug.
Moré
J
J
Laboratoire de Pharmacologie-Toxicologie, INRA, Toulouse, France.
Fioramonti
J
J
Buéno
L
L
D000284:Administration, Oral; D000536:Aluminum Hydroxide / Q000008:administration & dosage / Q000032:analysis* / Q000493:pharmacokinetics; D000818:Animals; D005753:Gastric Mucosa / Q000737:chemistry* / Q000378:metabolism; D006651:Histocytochemistry; D007413:Intestinal Mucosa / Q000737:chemistry* / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013194:Staining and Labeling
D000536:Aluminum Hydroxide