Inhibition of angiogenesis by suramin.
In this study, we have determined the ability of suramin to inhibit angiogenesis in the chick chorioallantoic membrane. Suramin alone showed significant angiostatic activity in a dose-related manner. Suramin also potentiated the activity of the angiostatic steroids, cortisol-21-phosphate, 17 alpha-hydroxyprogesterone, tetrahydrocortisol, and tetrahydrocortexolone. The presence of heparin decreased the angiostatic activity of suramin. These results suggest that suramin may decrease tumor growth by inhibiting angiogenesis. These novel findings indicate that suramin, perhaps in combination with angiostatic steroids, may be the basis for important new therapeutic approaches for diseases of neovascularization.
Gagliardi
A
A
Research Service, Veterans Administration Medical Center, Lexington, Kentucky.
Hadd
H
H
Collins
D C
DC
D000482:Allantois; D000818:Animals; D002642:Chick Embryo; D002823:Chorion; D004305:Dose-Response Relationship, Drug; D006493:Heparin / Q000494:pharmacology; D009389:Neovascularization, Pathologic; D013256:Steroids / Q000494:pharmacology; D013498:Suramin / Q000494:pharmacology*
D013256:Steroids; D013498:Suramin; D006493:Heparin