title: Suppression of experimental autoimmune encephalomyelitis by gallium nitrate.
abstract: We examined the effect of gallium (Ga) nitrate on the development of the development of experimental autoimmune encephalomyelitis (EAE). Weekly subcutaneous injections of 10-30 mg/kg prevented clinical signs as well as histopathological changes of EAE. The optimal timing of a single injection of Ga was 6 days after induction of EAE, with amelioration also apparent following a single injection on day 3 or 9 but not day 12. Ga administered in vivo suppressed myelin basic protein (MBP) and purified protein derivative-specific lymphocyte proliferative responses in vitro. Addition of Ga to MBP-specific T lymphocyte line cultures at various times after initiation of culture revealed that Ga exerts an effect at an early stage of cellular activation.
authors.affiliation: Department of Medical Microbiology and Immunology, College of Medicine, Ohio State University, Columbus 43210.
authors.forename: C
authors.initials: C
authors.lastname: Whitacre
authors.forename: G
authors.initials: G
authors.lastname: Apseloff
authors.forename: K
authors.initials: K
authors.lastname: Cox
authors.forename: V
authors.initials: V
authors.lastname: Matkovic
authors.forename: S
authors.initials: S
authors.lastname: Jewell
authors.forename: N
authors.initials: N
authors.lastname: Gerber
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000503:physiopathology*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D003208:Concanavalin A / Q000494:pharmacology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000503:physiopathology*; D005708:Gallium / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D004676:Myelin Basic Protein / Q000494:pharmacology; D051381:Rats; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects; D014373:Tuberculin
chemical_list: D004676:Myelin Basic Protein; D014373:Tuberculin; D003208:Concanavalin A; D005708:Gallium; C027235:gallium nitrate