Down-regulation of E1a expression by E3 gene products in group C adenoviruses.
Mutant group C adenoviruses defective in expression of the E3 transcription unit were found to overexpress E1a proteins relative to wild-type adenoviruses. This result suggests that one or more proteins encoded in the E3 region (present in wild-type viruses) down-regulate E1a expression. This interpretation was confirmed by transfection experiments in which a plasmid expressing the E3 region reduced expression of E1a in 293 cells. Experiments to examine the molecular basis of this down-regulation of E1a suggest that E3 protein products interfere with the translation of viral mRNA molecules.
Zhang
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Division of Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra.
Müllbacher
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Braithwaite
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AW
D017456:Adenovirus Early Proteins; D000260:Adenoviruses, Human / Q000235:genetics* / Q000276:immunology; D000818:Animals; D000957:Antigens, Viral, Tumor / Q000235:genetics*; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D002460:Cell Line; D015536:Down-Regulation / Q000235:genetics* / Q000276:immunology; D005347:Fibroblasts; D015967:Gene Expression Regulation, Viral / Q000276:immunology*; D005814:Genes, Viral; D051379:Mice; D009856:Oncogene Proteins, Viral / Q000235:genetics* / Q000276:immunology; D014157:Transcription Factors / Q000235:genetics
D017456:Adenovirus Early Proteins; D000957:Antigens, Viral, Tumor; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D009856:Oncogene Proteins, Viral; D014157:Transcription Factors; C068486:Tcfe3 protein, mouse