title: Suprasellar tumors of maldevelopmental origin in Klinefelter's syndrome. A report of two cases.
abstract: Patients with Klinefelter's syndrome may have a predisposition for the development of neoplasia, particularly extragonadal germ-cell tumors, but a suprasellar location is rarely reported. The clinical and neuroradiologic features in two patients with Klinefelter's syndrome and dysmorphic suprasellar masses of maldevelopmental origin (presumably lipomas or lipodermoids) are described. One patient had bilateral optic atrophy and decreased vision. To our knowledge, only one similar case (a suprasellar hamartoma) has been previously reported in association with Klinefelter's syndrome.
authors.affiliation: Department of Ophthalmology, University of Florida College of Medicine, Gainesville 32610-0284.
authors.forename: L M
authors.initials: LM
authors.lastname: Hamed
authors.forename: B L
authors.initials: BL
authors.lastname: Maria
authors.forename: R
authors.initials: R
authors.lastname: Quisling
authors.forename: M M
authors.initials: MM
authors.lastname: Fanous
authors.forename: P
authors.initials: P
authors.lastname: Mickle
mesh_terms: D001932:Brain Neoplasms / Q000150:complications* / Q000175:diagnosis; D002675:Child, Preschool; D003397:Craniopharyngioma / Q000150:complications / Q000175:diagnosis; D004814:Epidermal Cyst / Q000175:diagnosis; D006801:Humans; D007713:Klinefelter Syndrome / Q000150:complications*; D008067:Lipoma / Q000150:complications* / Q000175:diagnosis; D008297:Male; D012658:Sella Turcica