[Effects of morphine and naloxone administered to pregnant rats on the adrenal glands and testes of the offspring].
Relative testis and adrenal weights, testosterone and corticosterone levels in the blood were determined in 9-, 16-day and 2-month-old rats born to females injected with morphine (10 mg/kg/day), naloxone (10 mg/kg/day) or saline throughout the 15-18 days of gestation. Opioid receptors agonist morphine caused a long-lasting inhibition of the testes and activation of the adrenals. Saline injections to the females, that are known to be a stressor for them, also inhibited the testis of the neonatal offsprings. The block of the opioid receptors by the naloxone prevented the effect of prenatal stress on the testis, but inverted the negative correlation between the testes and the adrenals, that can be observed in the normal development.
Dygalo
N N
NN
Korani
L
L
Fel'tsegi
K
K
Endretsi
E
E
D000311:Adrenal Glands / Q000187:drug effects*; D000367:Age Factors; D000818:Animals; D003345:Corticosterone / Q000097:blood*; D005260:Female; D005333:Fetus / Q000187:drug effects*; D005865:Gestational Age; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013737:Testis / Q000187:drug effects*; D013739:Testosterone / Q000097:blood*
D009270:Naloxone; D013739:Testosterone; D009020:Morphine; D003345:Corticosterone