title: Localization of four human chromosome 21 genes--SOD1, ETS2, IFNAR, and CBR--to two different chromosomes in the marsupial species Macropus eugenii.
abstract: We have mapped the chromosomal location of four genes previously assigned to human chromosome 21--Cu/Zn superoxide dismutase (SOD1), the protooncogene ETS2, the interferon alpha/beta receptor gene (IFNAR), and the carbonyl reductase gene (CBR)--in the tammar, Macropus eugenii. The genes are localized on two separate autosomes: SOD1 and CBR map to chromosome 7 and ETS2 and IFNAR map to chromosome 3 or 4. These results provide the first example of asynteny between SOD1/CBR and ETS2/IFNAR in a mammalian species. The results suggest that either this synteny group has been disrupted in the marsupial lineage, or, alternatively, the genes located on human chromosome 21 may have been joined after the marsupials diverged from the eutherian mammals some 130-150 million years ago.
authors.affiliation: Molecular Embryology and Birth Defects Laboratory, Monash University, Clayton, Victoria, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Brookes
authors.forename: P
authors.initials: P
authors.lastname: Maccarone
authors.forename: J B
authors.initials: JB
authors.lastname: de Haan
authors.forename: M
authors.initials: M
authors.lastname: Tymms
authors.forename: G L
authors.initials: GL
authors.lastname: Forrest
authors.forename: J A
authors.initials: JA
authors.lastname: Graves
authors.forename: I
authors.initials: I
authors.lastname: Kola
mesh_terms: D000429:Alcohol Oxidoreductases / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D002891:Chromosomes, Human, Pair 21; D004268:DNA-Binding Proteins; D006801:Humans; D007372:Interferons / Q000235:genetics; D008394:Marsupialia / Q000235:genetics*; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D015345:Oligonucleotide Probes / Q000235:genetics; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D050787:Proto-Oncogene Protein c-ets-2; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D011971:Receptors, Immunologic / Q000235:genetics*; D017471:Receptors, Interferon; D012097:Repressor Proteins; D013482:Superoxide Dismutase / Q000235:genetics*; D015534:Trans-Activators; D014157:Transcription Factors
chemical_list: D004268:DNA-Binding Proteins; C107465:ERF protein, human; C494069:ETS2 protein, human; D015345:Oligonucleotide Probes; D050787:Proto-Oncogene Protein c-ets-2; D011518:Proto-Oncogene Proteins; D011971:Receptors, Immunologic; D017471:Receptors, Interferon; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D007372:Interferons; D000429:Alcohol Oxidoreductases; D013482:Superoxide Dismutase; D011505:Protein-Tyrosine Kinases