title: Differentiation therapy.
abstract: A variety of compounds are able to induce myeloid leukemia cells to differentiate into morphologically and functionally mature cells. Vitamin D derivatives, retinoids, interferons, and polar-planar compounds are agents that demonstrate such activity in vitro and have been employed as therapy for the myelodysplastic syndromes.
authors.affiliation: Division of Health Sciences, University of California, School of Medicine, Los Angeles.
authors.forename: R L
authors.initials: RL
authors.lastname: Paquette
authors.forename: H P
authors.initials: HP
authors.lastname: Koeffler
mesh_terms: D002117:Calcitriol / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002454:Cell Differentiation / Q000187:drug effects; D006410:Hematopoiesis / Q000187:drug effects; D006801:Humans; D007372:Interferons / Q000494:pharmacology / Q000627:therapeutic use; D009190:Myelodysplastic Syndromes / Q000188:drug therapy*; D012176:Retinoids / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D012176:Retinoids; D007372:Interferons; D002117:Calcitriol