title: Effects of gamma interferon and indomethacin in preventing Brucella abortus infections in mice.
abstract: Increased resistance to infection with Brucella abortus 2308 resulted when recombinant murine gamma interferon (rMuIFN-gamma) was given to mice both before and during infection but not when given only before infection. Mice given rMuIFN-gamma had enhanced peritoneal and splenic macrophage bactericidal activity against B. abortus. Treatment of mice with rMuIFN-gamma plus indomethacin did not further enhance resistance to infection or macrophage bactericidal activity compared with that after treatment of mice with rMuIFN-gamma alone.
authors.affiliation: Brucellosis Research Unit, National Animal Disease Center, Ames, Iowa 50010.
authors.forename: M G
authors.initials: MG
authors.lastname: Stevens
authors.forename: G W
authors.initials: GW
authors.lastname: Pugh
authors.forename: L B
authors.initials: LB
authors.lastname: Tabatabai
mesh_terms: D000818:Animals; D002003:Brucella abortus; D002006:Brucellosis / Q000276:immunology / Q000517:prevention & control*; D007113:Immunity, Innate / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology*; D007371:Interferon-gamma / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D011453:Prostaglandins / Q000502:physiology; D011994:Recombinant Proteins
chemical_list: D011453:Prostaglandins; D011994:Recombinant Proteins; D007371:Interferon-gamma; D007213:Indomethacin