Immunophenotype and cytochemical reactions of acute lymphoblastic leukemia in Thai children.
The immunophenotypes of acute lymphoblastic leukemia (ALL) in 28 Thai children were studied by the APAAP technique using a panel of eight specific monoclonal antibodies: HLA-DR, CD 19, CALLA (CD 10), IgM, CD 7, CD 3, CD 4, and CD 8. Sixty-eight, 18, 3.5, 3.5, and 7 per cent were respectively shown to be common, null, pre-B, B, and mature thymocyte T subtypes. Cytochemical reactions (beta-glucuronidase, alpha naphthyl acetate esterase, and acid phosphatase) in this study could identify null, common, and T ALLs with confidence, and could be used in the process of ALL subtyping to reduce cost.
Apibal
S
S
Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Bangkok, Thailand.
Atichartakarn
V
V
Salakit
C
C
Nitiyanant
P
P
Mahasandana
C
C
Supradish
P
P
Hathirat
P
P
D001856:Bone Marrow Examination / Q000592:standards*; D002648:Child; D005069:Evaluation Studies as Topic; D006651:Histocytochemistry / Q000592:standards*; D006776:Hospitals, Pediatric; D006785:Hospitals, University; D006801:Humans; D016130:Immunophenotyping / Q000592:standards*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000145:classification / Q000175:diagnosis* / Q000453:epidemiology; D012680:Sensitivity and Specificity; D013785:Thailand / Q000453:epidemiology