The effect of a protein meal on zidovudine pharmacokinetics in HIV-infected patients.
Eleven HIV-infected men participated in a randomized, two-treatment, two-period crossover study to determine the effect of a 25 g protein meal on zidovudine pharmacokinetics. On two separate occasions, 1 week apart, each patient received 200 mg zidovudine in a fasting state or immediately following the protein meal. A protein meal significantly decreased Cmax [532 (228 s.d.) vs 802 (452 s.d.) ng ml-1, P = 0.004] and increased mean residence time (138 (26 s.d.) vs 114 (26 s.d.) min, corrected for lag times, P = 0.001). However, AUC, tmax, terminal half-life and renal clearance were not significantly altered (P greater than 0.05). The power to detect a 20% change in AUC was 98% at the 5% significance level. In contrast to fat-containing foods, protein-based meals may not alter the extent of zidovudine absorption.
Sahai
J
J
Department of Medicine, Ottawa General Hospital, Ontario, Canada.
Gallicano
K
K
Garber
G
G
McGilveray
I
I
Hawley-Foss
N
N
Turgeon
N
N
Cameron
D W
DW
D004044:Dietary Proteins / Q000008:administration & dosage*; D015658:HIV Infections / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D008297:Male; D015215:Zidovudine / Q000493:pharmacokinetics*
D004044:Dietary Proteins; D015215:Zidovudine