title: Experience with tretinoin therapy in temperate regions.
abstract: In a previously reported study on the anti-photoageing effects of topical tretinoin, the following regimen produced good patient compliance: 0.01% for 1 month, 0.025% for 1 month; and 0.05% for 4 months. The majority of patients (60/89) enrolled in the initial study continued to apply the cream to the face, and a further 140 patients were enrolled for a long-term study (mean duration 2 years). The prolonged study showed that 91.4% of patients used tretinoin in an attempt to slow down skin aging, and 8.6% sought subjective skin benefits. Of the 163 patients who completed the study, 58.8% sought an improvement of wrinkles, 30.1% skin trophism and 14.7% reduced pigmentation. The product was used throughout the year by 66.9% of patients, but 8.0% stopped using it during the summer. A daytime moisturizing cream was required by 77.9% of patients, and 82.8% used a sunscreen in the summer. Tretinoin was applied to other areas of the body by 63.8% of patients.
authors.affiliation: First Department of Dermatology and Paediatric Dermatology, University of Milan, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Caputo
authors.forename: M
authors.initials: M
authors.lastname: Monti
authors.forename: C
authors.initials: C
authors.lastname: Rigoni
authors.forename: S
authors.initials: S
authors.lastname: Pinelli
authors.forename: S
authors.initials: S
authors.lastname: Motta
authors.forename: M
authors.initials: M
authors.lastname: Barbareschi
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D010349:Patient Compliance; D015595:Skin Aging / Q000187:drug effects*; D013997:Time Factors; D014212:Tretinoin / Q000008:administration & dosage*
chemical_list: D014212:Tretinoin