Pharmacokinetics of intragraft iloprost infusion during femoro-crural reconstruction.
Pharmacokinetics of a single intra-graft infusion of 3000ng iloprost during femoro-crural bypass surgery have been investigated. Plasma iloprost concentrations, biphasic half-lives, and total drug clearances were found to occur within ranges demonstrated for IV infusion dose regimens.
Smith
F C
FC
Department of Vascular Surgery, Queen Elizabeth Hospital, Birmingham, UK.
Hildebrand
M
M
Watson
H R
HR
Shearman
C P
CP
D000368:Aged; D005260:Female; D005263:Femoral Artery / Q000601:surgery*; D006801:Humans; D016285:Iloprost / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007262:Infusions, Intravenous; D007511:Ischemia / Q000601:surgery; D007866:Leg / Q000098:blood supply* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow / Q000502:physiology; D012501:Saphenous Vein / Q000637:transplantation; D014182:Transplantation, Autologous
D016285:Iloprost