title: Electrostimulation effects of the vagus nerve on balance in epilepsy.
abstract: Preliminary results of selected postural measures in quiet standing indicate that stimulation of the vagus nerve appears not to be producing adverse effects. With this specific sample size, more testing is needed to determine long-term effects and future data analyses will examine correlations between electroencephalogram results, drug levels, and seizure frequency. In the present study three subjects have had old injuries to hips and ankles. Two subjects had normal values for postural control prior to stimulation, while other subjects were severely abnormal. In future, studies should include larger homogeneous sample sizes, as the current subjects show marked variability in age and premorbid health backgrounds. Future work should also control more vigorously for variables such as visual input (i.e., blindfolding subjects instead of simply closing the eyes). Evaluation of postural control mechanisms will be continued to assess stability changes in these patients as seizure frequency continues to subside.
authors.affiliation: McMaster University Medical Centre, Hamilton, Ontario, Canada.
authors.forename: B M
authors.initials: BM
authors.lastname: Clarke
authors.forename: A R
authors.initials: AR
authors.lastname: Upton
authors.forename: M
authors.initials: M
authors.lastname: Kamath
authors.forename: H M
authors.initials: HM
authors.lastname: Griffin
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D004599:Electric Stimulation Therapy / Q000295:instrumentation* / Q000379:methods; D017029:Epilepsy, Complex Partial / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D004856:Postural Balance / Q000502:physiology*; D011187:Posture / Q000502:physiology; D019736:Prostheses and Implants; D013997:Time Factors; D014630:Vagus Nerve / Q000502:physiology*
chemical_list: D000927:Anticonvulsants