title: [Current data on GM-CSF (Granulocyte-Macrophage Colony Stimulating Factor) in acute myeloid leukemia].
abstract: GM-CSF (Granulocyte-Macrophage Colony Stimulating Factor) activates neutrophil, eosinophil, granular, and macrophage precursors through binding to specific receptors. GM-CSF receptor is a member of the "cytokine receptor superfamily", which displays a particular transmembrane structure. It is expressed in small amounts on normal mature blood or medullary cells, with a high affinity. On acute myeloid leukemia blasts (18 patients), our results agree with the review of the literature: GM-CSF receptors are in small amounts, of two types (high and low affinity), with no relation to the FAB classification of leukemias.
authors.affiliation: Service de médecine nucléaire, hôpital Saint-Louis, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: de Gentile
authors.forename: M H
authors.initials: MH
authors.lastname: Schlageter
authors.forename: I
authors.initials: I
authors.lastname: Krawice
authors.forename: H
authors.initials: H
authors.lastname: Dombret
authors.forename: Y
authors.initials: Y
authors.lastname: Najean
authors.forename: C
authors.initials: C
authors.lastname: Chomienne
authors.forename: M E
authors.initials: ME
authors.lastname: Toubert
mesh_terms: D003115:Colony-Stimulating Factors / Q000502:physiology*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood*; D016184:Receptors, Colony-Stimulating Factor / Q000032:analysis / Q000502:physiology
chemical_list: D003115:Colony-Stimulating Factors; D016184:Receptors, Colony-Stimulating Factor