The effect of calcium channel modulators on blood pressure and pressor responses to noradrenaline in the guinea-pig.
Selective L-type voltage-operated calcium channel (VOCC) antagonists nicardipine, diltiazem and verapamil all produced pronounced falls in mean arterial blood pressure (MAP) in the anaesthetized artificially ventilated guinea-pig. This fall in MAP was associated with a significant reduction of the pressor response induced by i.v. noradrenaline. omega-Conotoxin GVIA (CgTx) a preferential N-type VOCC antagonist produced a significant time-dependent fall in MAP, similar in magnitude to the L-type VOCC antagonist, but did not affect the noradrenaline-induced pressor responses.
Bond
A
A
Eli Lilly & Co., Lilly Research Centre Ltd., Windlesham, Surrey, UK.
Boot
J R
JR
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D006168:Guinea Pigs; D008297:Male; D008978:Mollusk Venoms / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology*; D020866:omega-Conotoxin GVIA
D002121:Calcium Channel Blockers; D008978:Mollusk Venoms; D020866:omega-Conotoxin GVIA; D009638:Norepinephrine