title: Bone marrow necrosis at transformation of chronic granulocytic leukaemia treated with interferon.
abstract: A patient with chronic myeloid leukaemia was treated with interferon without using conventional cytotoxic agents. Bone marrow necrosis developed at the onset of blast transformation. It is suggested that cytotoxic drugs should be given before treatment with interferon for chronic myeloid leukaemia. Cytotoxic drugs may also be needed to prevent rapid bone marrow growth once interferon has been withdrawn.
authors.affiliation: Department of Haematology, Burnley General Hospital, Lancs.
authors.forename: J R
authors.initials: JR
authors.lastname: Kendra
authors.forename: S
authors.initials: S
authors.lastname: Pickens
authors.forename: A K
authors.initials: AK
authors.lastname: Singh
authors.forename: K
authors.initials: K
authors.lastname: Singh
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009336:Necrosis
chemical_list: D000970:Antineoplastic Agents; D016898:Interferon-alpha