Granulocyte colony-stimulating factor-producing malignant lymphoma.
A 71-year-old woman with leukocytosis was admitted for treatment of malignant lymphoma. During the clinical course, neutrophilia of unknown origin occurred in parallel with the progression of the malignant lymphoma. The supernatant of lymphoma tissue culture contained a high titer of granulocyte colony-stimulating factor (G-CSF), and lymphoma cells were positive when immunohistochemically stained by anti-G-CSF antibody. Western blot analysis and mouse colony assay of the supernatant also confirmed that the lymphoma produced G-CSF.
Ohtsuki
T
T
Department of Internal Medicine III, National Defense Medical College, Saitama, Japan.
Matsu-ura
Y
Y
Suzu
S
S
Mizukami
H
H
Ohnishi
M
M
Kimura
F
F
Nagata
N
N
Motoyoshi
K
K
D000368:Aged; D015153:Blotting, Western; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000737:chemistry; D008223:Lymphoma / Q000737:chemistry / Q000378:metabolism*
D016179:Granulocyte Colony-Stimulating Factor