Effects of interferon alpha on murine cytomegalovirus replication.
The present study examined the protective effect of IFN-alpha against mouse cytomegalovirus (MCMV) infection in embryo fibroblasts (MEF) of genetically resistant (C3H/HeJ) and susceptible (C57BL/6) mouse strains. At a M.O.I. of 1 IFN-alpha was protective in C3H/HeJ-MEF but not in C57BL/6-MEF. Dot-blot analysis during MCMV replication in C3H/HeJ-MEF showed that IFN-alpha pretreatment reduced the steady state level of immediate early and late mRNAs but partially reduced early gene expression.
Martinotti
M G
MG
Instituto di Microbiologia, Università di Torino, Italy.
Gribaudo
G
G
Gariglio
M
M
Angeretti
A
A
Cavallo
G
G
Landolfo
S
S
D000818:Animals; D003587:Cytomegalovirus / Q000187:drug effects* / Q000254:growth & development; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000382:microbiology; D016898:Interferon-alpha / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D009693:Nucleic Acid Hybridization; D012313:RNA / Q000032:analysis; D014779:Virus Replication / Q000187:drug effects
D016898:Interferon-alpha; D012313:RNA