[Malaria and hemoglobin S: interactions in African children].
Among 300 cases of Plasmodium falciparum malaria attacks explored in Gabon, the proportion of homozygous (SS) or heterozygous (AS) sickle-cell patients was 6.2 percent in 206 ordinary attacks and 3.2 percent in 94 cerebral malaria attacks, and 23.2 percent in the general population. On the other hand, asymptomatic carriage, as detected in 98 children by thin blood films in school screening, was as frequent in the SS or AS infantile population as in the general population. These data show that haemoglobin S protects effectively, although not entirely, against severe attacks of P. falciparum malaria. The incidence of anaemia and vaso-obstructive crisis in malaria-infested sickle-cell patients suggests that subclinical carriage of haematozoa may worsen the course of sickle-cell disease, and this must be taken into account when planning treatment.
Gendrel
D
D
Département de Pédiatrie, Hôpital Saint-Vincent-de-Paul, Paris.
Kombila
M
M
Nardou
M
M
Gendrel
C
C
Djouba
F
F
Martz
M
M
Richard-Lenoble
D
D
D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D004588:Electrophoresis, Cellulose Acetate; D005681:Gabon; D006451:Hemoglobin, Sickle / Q000032:analysis*; D006801:Humans; D016778:Malaria, Falciparum / Q000097:blood* / Q000188:drug therapy / Q000517:prevention & control; D011446:Prospective Studies; D011803:Quinine / Q000627:therapeutic use
D006451:Hemoglobin, Sickle; D011803:Quinine