title: Late potentials in an ovine model of acute transmural myocardial infarction.
abstract: The development of slow conduction during the first hours of acute transmural myocardial infarction (ATMI) was studied by signal-averaged electrocardiograms (SAE) in 19 adult anesthetized sheep. SAEs were recorded before and after intravenous infusions of lidocaine and bretylium were begun and 10, 30, and 60 min after ATMI produced by ligation of the left anterior descending and second diagonal coronary arteries. Four sheep died promptly of ventricular tachyarrhythmias; two others developed sustained ventricular arrhythmias, which precluded additional data. Biphasic changes in QRS duration, root mean square voltage of the terminal 40 ms of the QRS complex, and duration of terminal low-amplitude (less than 30 microV) signal were observed. Peak changes in conduction occurred 30 min after infarction and regressed toward baseline thereafter. At 30 min, all animals developed late potentials, which were defined as signals that exceeded both after-drug QRS duration and duration of terminal low-amplitude signal less than 30 microV by more than two standard deviations. At 60 min, only 3 of 13 (23%) animals had late potentials. Conduction is slowest 30 min after ATMI in sheep but may not be related to development of ventricular arrhythmias. In five of six sheep (83%), ventricular arrhythmias occurred within 15 min of infarction before peak slowing was observed by SAE.
authors.affiliation: Department of Surgery, University of Pennsylvania, Philadelphia 19104.
authors.forename: G
authors.initials: G
authors.lastname: Kreiner
authors.forename: C D
authors.initials: CD
authors.lastname: Gottlieb
authors.forename: S
authors.initials: S
authors.lastname: Furukawa
authors.forename: M B
authors.initials: MB
authors.lastname: Simson
authors.forename: G S
authors.initials: GS
authors.lastname: Tyson
authors.forename: L H
authors.initials: LH
authors.lastname: Edmunds
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004562:Electrocardiography; D004594:Electrophysiology; D009203:Myocardial Infarction / Q000150:complications / Q000503:physiopathology*; D012756:Sheep; D017180:Tachycardia, Ventricular / Q000209:etiology / Q000503:physiopathology; D013997:Time Factors