title: Experimental atrophic rhinitis in 2 and 4 month old pigs infected sequentially with Bordetella bronchiseptica and toxigenic type D Pasteurella multocida.
abstract: Experimental infections with Bordetella bronchiseptica and/or toxigenic type D Pasteurella multocida were studied in 2- and 4-month-old primary specific-pathogen-free pigs. None of the 2-month-old pigs inoculated with B. bronchiseptica or P. multocida alone developed turbinate atrophy. All the pigs inoculated with B. bronchiseptica (10(7) CFU/head) and P. multocida (10(9) CFU/head for 5 consecutive days) together, however, developed clinical and post-mortem signs of atrophic rhinitis (AR) similar to the naturally occurring disease. Slight to severe turbinate atrophy was observed in the 4-month-old pigs inoculated with B. bronchiseptica and P. multocida (at the same concentration as above) at necropsy.
authors.affiliation: Zen-noh Institute of Animal Health, Sakura, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sakano
authors.forename: M
authors.initials: M
authors.lastname: Okada
authors.forename: A
authors.initials: A
authors.lastname: Taneda
authors.forename: M
authors.initials: M
authors.lastname: Ono
authors.forename: S
authors.initials: S
authors.lastname: Sato
mesh_terms: D000818:Animals; D001284:Atrophy; D001885:Bordetella Infections / Q000150:complications / Q000662:veterinary*; D016950:Bordetella bronchiseptica / Q000502:physiology; D010326:Pasteurella Infections / Q000150:complications / Q000662:veterinary*; D016979:Pasteurella multocida / Q000502:physiology; D012222:Rhinitis, Atrophic / Q000382:microbiology / Q000662:veterinary*; D013047:Specific Pathogen-Free Organisms; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology*; D014420:Turbinates / Q000473:pathology