title: Effect of soft x-ray irradiation on immunological functions in mice.
abstract: Effect of soft x-ray irradiation on immunological functions in mice was investigated. Soft x-ray irradiation with 100R or more induced a significant reduction in the number of plaque-forming cells (PFC). The reduction in the number of PFC depended on the irradiation doses. Irradiation with 600R or more showed a significant reduction in the delayed reaction of footpad swelling. However, soft x-ray irradiation with doses ranging from 100R to 1000R did not exert significant influence on the K values of carbon clearance test. Irradiation with 100R or more of soft x-ray showed a remarkable reduction of response to concanavalinA (ConA) or lipopolysaccharide (LPS) in spleen cells, and the response to ConA was lower than that to LPS. These results suggest that in the soft x-ray-irradiated mice, antibody-producing ability, delayed type hypersensitivity reaction and mitogenic activity are sensitive to soft x-ray irradiation and furthermore, T cell is more sensitive than B cell, but phagocytic activity of reticulo-endothelial system (RES) is resistant to soft x-ray irradiation.
authors.affiliation: United Department of Basic Veterinary Sciences, United Graduate School of Veterinary Sciences, Yamaguchi University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Takeuchi
authors.forename: H
authors.initials: H
authors.lastname: Shibata
authors.forename: T
authors.initials: T
authors.lastname: Nasu
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000528:radiation effects*; D002478:Cells, Cultured; D003208:Concanavalin A / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular / Q000528:radiation effects*; D008070:Lipopolysaccharides / Q000528:radiation effects; D008213:Lymphocyte Activation / Q000528:radiation effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D012157:Mononuclear Phagocyte System / Q000276:immunology / Q000528:radiation effects; D010587:Phagocytosis / Q000528:radiation effects*; D013154:Spleen / Q000166:cytology / Q000276:immunology / Q000528:radiation effects
chemical_list: D008070:Lipopolysaccharides; D003208:Concanavalin A