PEG-bovine hemoglobin: safety in a canine dehydrated hypovolemic-hemorrhagic shock model.
An initial evaluation of PEG-bHb was performed using a modified hypovolemic shock model. PEG-bHb had a substantially longer intravascular half-life than native Hb and no measurable hemoglobinuria was observed in the canine. PEG-bHb allowed successful resuscitation with an oxygen carrying capacity of 14-22% over that of lactated Ringer's solution.
Nho
K
K
Duke University Medical Center, Dept. of Surgery, Durham, NC 27710.
Glower
D
D
Bredehoeft
S
S
Shankar
H
H
Shorr
R
R
Abuchowski
A
A
D000818:Animals; D001802:Blood Substitutes / Q000302:isolation & purification / Q000627:therapeutic use* / Q000633:toxicity; D003681:Dehydration / Q000628:therapy*; D004195:Disease Models, Animal; D004285:Dogs; D006207:Half-Life; D006454:Hemoglobins / Q000302:isolation & purification / Q000378:metabolism / Q000627:therapeutic use*; D007552:Isotonic Solutions / Q000627:therapeutic use; D011092:Polyethylene Glycols; D012151:Resuscitation; D000077325:Ringer's Lactate; D012449:Safety; D012769:Shock / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D012771:Shock, Hemorrhagic / Q000628:therapy
D001802:Blood Substitutes; D006454:Hemoglobins; D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D011092:Polyethylene Glycols