title: Variable gene usage, physiology and development of Ly-1+ (CD5+) B cells.
abstract: Two related features of Ly-1+ B cells (CD5+ B cells in man) are their biased specificities and variable gene usage, and their relationship to the bulk of Ly-1- ('conventional') B cells. An emerging model views Ly-1+ B cells as a memory population in the adult animal, whose generation is largely limited to fetal and neonatal development. Selection based on germline-encoded self-reactivity then shapes the adult repertoire.
authors.affiliation: Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia.
authors.forename: R R
authors.initials: RR
authors.lastname: Hardy
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000276:immunology*; D000950:Antigens, Ly / Q000276:immunology*; D016175:B-Lymphocyte Subsets / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D018956:CD5 Antigens; D005803:Genes, Immunoglobulin / Q000276:immunology*; D006801:Humans; D016130:Immunophenotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology; D008223:Lymphoma / Q000276:immunology
chemical_list: D015703:Antigens, CD; D000950:Antigens, Ly; D018956:CD5 Antigens