Concomitant release of renin, angiotensin I, and angiotensin II during superfusion of human juxtaglomerular cell tumor.
Increasing evidence indicates that angiotensin II can be formed by juxtaglomerular cells (JGC) and cosecreted with renin. We investigated the existence of this local renin-angiotensin system in a human JGC tumor, using an in vitro superfusion. The JGC tumor was found concomitantly to release renin and angiotensin I and II. Sequential addition of atrial natriuretic peptide, dopamine, and a somatostatin analog in the superfusion did not affect renin or angiotensin I and II release. The data provide evidence that the human JGC tumor in vitro generates angiotensin II, and supports its possible role as a local in vivo regulator of kidney function.
Fallo
F
F
Institute of Semeiotica Medica, University of Padova, Italy.
D'Agostino
D
D
Armanini
D
D
Caregaro
L
L
Mantero
F
F
D000328:Adult; D000803:Angiotensin I / Q000378:metabolism*; D000804:Angiotensin II / Q000378:metabolism*; D009320:Atrial Natriuretic Factor / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D005260:Female; D006801:Humans; D007606:Juxtaglomerular Apparatus; D007680:Kidney Neoplasms / Q000378:metabolism* / Q000648:ultrastructure; D008854:Microscopy, Electron; D015282:Octreotide / Q000494:pharmacology; D010477:Perfusion; D012083:Renin / Q000378:metabolism*
D000804:Angiotensin II; D009320:Atrial Natriuretic Factor; D000803:Angiotensin I; D012083:Renin; D015282:Octreotide; D004298:Dopamine