Rhenium-186 hydroxyethylidene diphosphonate for the treatment of painful osseous metastases.
Rhenium-186 (tin)hydroxyethylidene diphosphonate (HEDP) is a new radiopharmaceutical that localizes in skeletal metastases in patients with advanced cancer. A single intravenous administration of approximately 34 mCi (1,258 MBq) resulted in significant improvement in pain in 33 of 43 evaluable patients (77%) following the initial injection, and in 7 of 14 evaluable patients (50%) following a second treatment. Patients responding to treatment experienced an average decrease in pain of about 60%, with one in five treatments resulting in a complete resolution of pain. The only adverse clinical reaction was the occurrence after about 10% of the administered doses of a mild, transient increase in pain within a few days following injection. Statistically significant but clinically unimportant decreases in total white blood cell counts and total platelet counts were observed within the first 8 weeks following the injection; no other toxicity was apparent. Rhenium-186(Sn)HEDP is a useful new compound for the palliation of painful skeletal metastases.
Maxon
H R
HR
Department of Radiology, Eugene L. Saenger Radioisotope Laboratory, University of Cincinnati Medical Center, OH 45267-0577.
Thomas
S R
SR
Hertzberg
V S
VS
Schroder
L E
LE
Englaro
E E
EE
Samaratunga
R
R
Scher
H I
HI
Moulton
J S
JS
Deutsch
E A
EA
Deutsch
K F
KF
D001859:Bone Neoplasms / Q000503:physiopathology / Q000556:secondary*; D012968:Etidronic Acid / Q000627:therapeutic use*; D006801:Humans; D009942:Organometallic Compounds / Q000627:therapeutic use*; D010146:Pain / Q000209:etiology / Q000532:radiotherapy*; D010166:Palliative Care
D009942:Organometallic Compounds; C064573:rhenium-186(tin)etidronate; D012968:Etidronic Acid