The polar-lethal Ovum mutant gene maps to the distal portion of mouse chromosome 11.
Genome imprinting is the process by which identical alleles at a particular locus may be rendered functionally different depending on the sex of the parent contributing the allele. While several mutations in imprinted genes have been defined, no variants in the regulatory system that gives rise to imprinting have been described. Here we report our genetic analysis of the behavior of the interstrain, polar, embryonic-lethal phenotype known as the "DDK syndrome." We have mapped the interstrain, polar-lethal region of the genome to the distal portion of mouse chromosome 11, near the Xmv-42 locus. We propose that the lethal phenotype is not caused by a standard mutation, but by aberrant imprinting of a gene within this region.
Sapienza
C
C
Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla 92093-0660.
Paquette
J
J
Pannunzio
P
P
Albrechtson
S
S
Morgan
K
K
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005260:Female; D005804:Genes, Lethal / Q000235:genetics*; D005838:Genotype; D007248:Infertility, Male / Q000235:genetics; D008098:Litter Size / Q000235:genetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D008957:Models, Genetic; D009841:Oligonucleotides / Q000235:genetics; D010641:Phenotype; D011533:Proviruses / Q000235:genetics; D011995:Recombination, Genetic / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid
D009841:Oligonucleotides