Theoretical mechanisms for synthesis of carcinogen-induced embryonic proteins: XXVII. Intermediate generalizations (Part B).
In this second section of generalizations, methylation, differentiation and carcinogenesis are reviewed. Special consideration is given to the alpha-fetoprotein gene which is used extensively as a model embryonic gene. Specific correlations are made between the glucocorticoid response element and the alpha-fetoprotein gene. A further correlation was made between retinoic acid and alpha-fetoprotein synthesis.
Hancock
R L
RL
Canadian Institute of Theoretical Biology, Scott's Bay, Nova Scotia.
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic; D004247:DNA / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D005326:Fetal Proteins / Q000096:biosynthesis* / Q000235:genetics; D015870:Gene Expression; D008099:Liver / Q000166:cytology / Q000378:metabolism; D008745:Methylation; D051379:Mice; D008954:Models, Biological; D000509:alpha-Fetoproteins / Q000096:biosynthesis / Q000235:genetics
D002273:Carcinogens; D005326:Fetal Proteins; D000509:alpha-Fetoproteins; D004247:DNA