title: Prolonged shelf stability and biocompatibility of a concentrated injectable fluorocarbon emulsion.
abstract: A four-year-old 100% w/v concentrated emulsion of perfluorooctylbromide (PFOB, perflubron) stored at 5 degrees C, when submitted to the close-to-total exchange-perfusion test in conscious rats (Hct 3-5%) still resulted in 75% survival. Particle size and size distribution, viscosity, pH were still in the acceptable range.
authors.affiliation: Centre Départemental de Transfusion Sanguine, Laurent du Var, France.
authors.forename: R
authors.initials: R
authors.lastname: Follana
authors.forename: D
authors.initials: D
authors.lastname: Klein
authors.forename: M P
authors.initials: MP
authors.lastname: Krafft
authors.forename: D M
authors.initials: DM
authors.lastname: Long
authors.forename: C D
authors.initials: CD
authors.lastname: Long
authors.forename: Y
authors.initials: Y
authors.lastname: Ni
authors.forename: J G
authors.initials: JG
authors.lastname: Riess
authors.forename: A
authors.initials: A
authors.lastname: Valla
mesh_terms: D000818:Animals; D001802:Blood Substitutes / Q000008:administration & dosage; D004355:Drug Stability; D004655:Emulsions; D005078:Exchange Transfusion, Whole Blood; D005466:Fluorocarbons / Q000008:administration & dosage; D006842:Hydrocarbons, Brominated; D008422:Materials Testing; D051381:Rats; D013997:Time Factors
chemical_list: D001802:Blood Substitutes; D004655:Emulsions; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; C003072:perflubron