title: Midpregnancy plasma zinc in normal and growth retarded fetuses--a preliminary study.
abstract: OBJECTIVE
  To determine plasma zinc concentrations in normally and abnormally growing fetuses.
  
  
  METHODS
  Prospective observational study.
  
  
  METHODS
  Fetal Medicine Unit, Queen Charlotte's Maternity Hospital.
  
  
  METHODS
  53 pregnant women attending for fetal blood sampling at between 18 and 40 weeks gestation. 27 fetuses were normal (central group), 11 fetuses were growth retarded and 15 were malformed.
  
  
  METHODS
  Plasma zinc concentrations in maternal and fetal blood at time of fetal blood sampling.
  
  
  RESULTS
  In normally growing fetuses, between 18 and 40 weeks gestation, there was no fall in maternal plasma zinc concentration; the fetal level fell by 36%. In 10 fetuses with symmetrical growth retardation, plasma zinc concentration tended to be low, but was not significantly different from that in the normal control fetuses.
  
  
  CONCLUSIONS
  The results suggest that (i) placental transfer of zinc is an uphill secretory process and that it is a rate-limiting step in the accumulation of zinc by the fetus and (ii) in fetuses with symmetrical intrauterine growth retardation, a low plasma zinc is probably a parallel phenomenon and not necessarily an aetiological factor.
authors.affiliation: Royal Postgraduate Medical School, London, UK.
authors.forename: H
authors.initials: H
authors.lastname: Nasrat
authors.forename: D
authors.initials: D
authors.lastname: Bloxam
authors.forename: U
authors.initials: U
authors.lastname: Nicolini
authors.forename: N
authors.initials: N
authors.lastname: Williams
authors.forename: Y
authors.initials: Y
authors.lastname: Tannirandorn
authors.forename: P
authors.initials: P
authors.lastname: Nicolaides
authors.forename: C H
authors.initials: CH
authors.lastname: Roedeck
mesh_terms: D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005317:Fetal Growth Retardation / Q000097:blood*; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy / Q000097:blood*; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D015032:Zinc / Q000097:blood*; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000509:alpha-Fetoproteins; D015032:Zinc