[Immunomodulation in dystrophic diseases of the joints].
Immunological examinations of 357 patients with mixed arthritis, coxarthrosis and aseptic necrosis of the femoral head have revealed substantial immunopathological deviations requiring immunomodulation and influencing surgical outcomes, with inhibition or dysfunction of T and B cellular reactions, inversion of the regulatory index, remarkable autoimmune component, and bacterial sensitization in a considerable part of the examined. In addition to the conventional immunomodulating agents (levamisole, thymalin, T-activin, sodium nucleinate), it is recommended that hemodes and polyglucin may be used, provided they are chosen individually in vitro. The use of ELISA made it possible to reveal a direct strong correlation between the level of antibodies to glycolipid cartilaginous antigen and arteparon as well as a decrease of the number of antibodies in therapeutic administration of the drug. This suggests the immunological mechanisms of the action of arteparon, namely according to the principle of hapten inhibition.
Delevskiĭ
Iu P
IuP
Isaeva
E G
EG
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D001168:Arthritis / Q000276:immunology / Q000628:therapy; D001323:Autoantibodies / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D005271:Femur Head Necrosis / Q000276:immunology / Q000628:therapy; D006801:Humans; D007592:Joint Diseases / Q000276:immunology / Q000628:therapy*; D015207:Osteoarthritis, Hip / Q000276:immunology / Q000628:therapy
D000276:Adjuvants, Immunologic; D001323:Autoantibodies