Induction of micronuclei in V79 Chinese hamster cells by tetrachlorohydroquinone, a metabolite of pentachlorophenol.
Tetrachlorohydroquinone, a metabolite of the fungicide pentachlorophenol, induced significant dose-related increases in micronuclei in V79 Chinese hamster cells without exogenous metabolic activation. The lowest observed effective dose was 10 microM, where the relative survival was about 62%. At the highest dose tested, 20 microM, the relative survival was about 8% and the frequency of cells with micronuclei was about 6 times the solvent control frequency. The induction of micronuclei by tetrachlorohydroquinone was significantly inhibited by the hydroxyl radical scavenger dimethyl sulfoxide at 5% (v/v).
Jansson
K
K
Department of Cell Biology, University of Jyväskylä, Finland.
Jansson
V
V
D000818:Animals; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D004249:DNA Damage; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D006873:Hydroquinones / Q000633:toxicity*; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects*; D015162:Micronucleus Tests; D010416:Pentachlorophenol / Q000378:metabolism*
D006873:Hydroquinones; C044578:2,3,5,6-tetrachlorohydroquinone; D010416:Pentachlorophenol; D004121:Dimethyl Sulfoxide