The Scottish first episode schizophrenia study. VIII. Five-year follow-up: clinical and psychosocial findings. The Scottish Schizophrenia Research Group.
Forty-four schizophrenic patients were followed up for five years after their first admission to hospital for a first episode of illness. Thirteen (30%) of 43 patients had not relapsed; 28 of the 30 patients who did relapse did so within the first 42 months. The relapses occurred despite antipsychotic drug therapy. Also, 24% of patients had at least one course of ECT. Only 19% of the patients at five years were in open employment; unemployment was strongly associated with relapse. Eighteen per cent had neither relapses nor schizophrenic symptoms at follow-up. Poor outcome at five years was associated with greater psychological distress among relatives at first admission. At five years 43% of relatives continued to show case level psychological stress.
D000203:Activities of Daily Living / Q000523:psychology*; D000284:Administration, Oral; D000328:Adult; D017028:Caregivers / Q000523:psychology; D003131:Combined Modality Therapy; D004311:Double-Blind Method; D005260:Female; D005475:Flupenthixol / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D005500:Follow-Up Studies; D006760:Hospitalization / Q000639:trends*; D006801:Humans; D008297:Male; D017533:Marital Status; D010868:Pimozide / Q000009:adverse effects / Q000627:therapeutic use; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D011594:Psychometrics; D012050:Rehabilitation, Vocational / Q000639:trends*; D012559:Schizophrenia / Q000175:diagnosis / Q000534:rehabilitation*; D012565:Schizophrenic Psychology; D012606:Scotland; D012917:Social Adjustment
D010868:Pimozide; C007761:flupenthixol decanoate; D005475:Flupenthixol