Sultriecin, a new antifungal and antitumor antibiotic from Streptomyces roseiscleroticus. Production, isolation, structure and biological activity.
Streptomyces roseiscleroticus L827-7 (ATCC 53903) produced a novel antifungal and antitumor antibiotic, sultriecin. It exhibited in vitro antifungal activity and potent in vivo antitumor activity against P388 and L1210 leukemias, and B16 melanoma. Sultriecin is composed of several unique structural units; a conjugated triene, an alpha,beta-unsaturated delta-lactone, and a sulfate functionality.
Ohkuma
H
H
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
Naruse
N
N
Nishiyama
Y
Y
Tsuno
T
T
Hoshino
Y
Y
Sawada
Y
Y
Konishi
M
M
Oki
T
T
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007783:Lactones / Q000302:isolation & purification / Q000494:pharmacology; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D011753:Pyrones; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; D007783:Lactones; D011753:Pyrones; C077328:sultriecin