Nuclear internalisation and DNA binding activities of interleukin-1, interleukin-1 receptor and interleukin-1/receptor complexes.
This paper presents evidence to suggest that interleukin-1 alpha as a complex with its receptor is able to express DNA binding activity. Both the interleukin-1/receptor complex and the interleukin-1 receptor appear to be able to bind to DNA, however interleukin-1 on its own showed no binding activity. Interleukin-1 was found to be internalised into the nuclei of all cells examined (EL4, MEL, HL-60, K562, THP-1 and Jurkat cells). The data suggest the possible modulation of genes by interaction of interleukin-1/receptor complexes with DNA structures.
Weitzmann
M N
MN
Department of Medical Biochemistry, University of the Witwatersrand Medical School, Johannesburg, South Africa.
Savage
N
N
D002460:Cell Line; D002467:Cell Nucleus / Q000378:metabolism*; D002845:Chromatography; D003101:Collodion; D004247:DNA / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism*; D007457:Iodine Radioisotopes; D007700:Kinetics; D011971:Receptors, Immunologic / Q000378:metabolism*; D017472:Receptors, Interleukin-1
D007375:Interleukin-1; D007457:Iodine Radioisotopes; D011971:Receptors, Immunologic; D017472:Receptors, Interleukin-1; D003101:Collodion; D004247:DNA