Cortisol and prolactin responses to d-fenfluramine in non-depressed patients with obsessive-compulsive disorder: a comparison with depressed and healthy controls.
Cortisol and prolactin responses to d-fenfluramine were measured in 10 drug-free normothymic patients with obsessive-compulsive disorder (OCD). The results were compared with these responses in 10 healthy controls and in 10 major depressives. The endocrine responses in OCD were significantly attenuated when compared to the healthy controls; however, the results were not specific to OCD as the depressives' responses were similarly blunted.
Lucey
J V
JV
Department of Psychiatry, Trinity College Medical School, St James Hospital, Dublin, Ireland.
O'Keane
V
V
Butcher
G
G
Clare
A W
AW
Dinan
T G
TG
D000328:Adult; D001143:Arousal / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D003866:Depressive Disorder / Q000097:blood / Q000175:diagnosis*; D005277:Fenfluramine; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000097:blood / Q000175:diagnosis*; D011388:Prolactin / Q000097:blood*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology; D012016:Reference Values
D011985:Receptors, Serotonin; D005277:Fenfluramine; D011388:Prolactin; D006854:Hydrocortisone