title: Effect of naloxone-precipitated morphine withdrawal on noradrenaline release in rat hippocampus in vivo.
abstract: Here we investigated the effect of naloxone-precipitated morphine withdrawal on the release of noradrenaline in hippocampus of the anaesthetised rat. Naloxone (1 mg/kg i.p.) injected 3 and 24 h, but not 3 weeks, after eight daily injections of morphine, induced an immediate increase in hippocampal noradrenaline release. This striking effect of naloxone was markedly attenuated by pretreatment with clonidine (0.1 mg/kg s.c.). These findings provide direct evidence for a marked release of noradrenaline in hippocampus during opiate withdrawal in vivo.
authors.affiliation: MRC Unit, Radcliffe Infirmary, Oxford, UK.
authors.forename: C
authors.initials: C
authors.lastname: Done
authors.forename: P
authors.initials: P
authors.lastname: Silverstone
authors.forename: T
authors.initials: T
authors.lastname: Sharp
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003000:Clonidine / Q000494:pharmacology; D003956:Dialysis; D004563:Electrochemistry; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D008125:Locus Coeruleus / Q000187:drug effects; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013375:Substance Withdrawal Syndrome / Q000378:metabolism*; D019966:Substance-Related Disorders / Q000378:metabolism
chemical_list: D009270:Naloxone; D009020:Morphine; D003000:Clonidine; D009638:Norepinephrine