title: Reactive lentiginous hyperpigmentation after cryosurgery for lentigo maligna.
abstract: BACKGROUND
  Twenty patients treated for lentigo maligna of the face with cryosurgery developed benign lentiginous hyperpigmentation mimicking a recurrence.
  
  
  OBJECTIVE
  When cryosurgery is used in the treatment of lentigo maligna, it is important to know whether repigmentation of the scar represents true recurrence or a benign process.
  
  
  METHODS
  Twenty patients were treated with cryosurgery for lentigo maligna of the face. Within a follow-up period of 7 to 80 months, frequent clinical observations were made.
  
  
  RESULTS
  Lentiginous hyperpigmentation developed within the treatment area in eight patients. Histologic investigation revealed recurrence of lentigo maligna in three and benign hyperpigmentation in five.
  
  
  CONCLUSIONS
  Genetic factors and UV exposure after cryosurgery may favor the development of benign lentiginous hyperpigmentation. Because recurrence of lentigo maligna must be considered, histologic evaluation of repigmentation is mandatory.
authors.affiliation: Department of Dermatology II, University of Vienna, Austria.
authors.forename: K
authors.initials: K
authors.lastname: Böhler-Sommeregger
authors.forename: S
authors.initials: S
authors.lastname: Schuller-Petrovic
authors.forename: R
authors.initials: R
authors.lastname: Knobler
authors.forename: P R
authors.initials: PR
authors.lastname: Neumann
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy; D003452:Cryosurgery / Q000009:adverse effects* / Q000379:methods; D004817:Epidermis / Q000473:pathology; D005148:Facial Dermatoses / Q000209:etiology* / Q000473:pathology; D005153:Facial Neoplasms / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015603:Keratinocytes / Q000473:pathology; D007911:Lentigo / Q000209:etiology* / Q000473:pathology; D008297:Male; D008543:Melanins; D008544:Melanocytes / Q000473:pathology; D008545:Melanoma / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery*
chemical_list: D008543:Melanins