Growth hormone and the kidney: a case presentation and review of the literature.
Hypersomatotropism is accompanied by a significant increase in GFR and RPF. A case of a patient with acromegaly and supranormal renal function as measured by inulin and p-aminohippurate clearances is reported. The literature regarding the effects of growth hormone on renal function is reviewed, and the potential mechanisms of action and therapeutic implications of these effects are discussed.
O'Shea
M H
MH
Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Layish
D T
DT
D000172:Acromegaly / Q000266:history / Q000378:metabolism; D000328:Adult; D001834:Body Water / Q000378:metabolism; D005110:Extracellular Space / Q000378:metabolism; D005919:Glomerular Filtration Rate; D013006:Growth Hormone / Q000378:metabolism / Q000494:pharmacology*; D049673:History, 20th Century; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology; D007668:Kidney / Q000378:metabolism* / Q000473:pathology; D007674:Kidney Diseases / Q000378:metabolism* / Q000473:pathology; D008297:Male
D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone