title: Comparative virulence of NAD-dependent and NAD-independent Actinobacillus pleuropneumoniae strains.
abstract: The virulence of a NAD-independent Actinobacillus pleuropneumoniae serotype 2 strain and NAD-dependent serotype 2, 3 and 9 strains was compared under experimental conditions. Hysterectomy-derived piglets were inoculated endobronchially with 50-500 cfu of these strains. All 23 piglets inoculated with the NAD-dependent strains developed acute disease within 12 hours post inoculation. Twenty-two of these piglets died within 24 hours after the first clinical signs. Three of nine piglets inoculated with the NAD-independent strain did not develop clinical disease. In the other six piglets, disease signs were similar as in the piglets inoculated with the NAD-dependent strains. No differences in clinical disease were observed between colostrum deprived piglets and piglets that obtained colostrum from a SPF sow.
authors.affiliation: Laboratory of Veterinary Bacteriology, Faculty of Veterinary Medicine, University of Gent, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Dom
authors.forename: F
authors.initials: F
authors.lastname: Haesebrouck
mesh_terms: D000189:Actinobacillus Infections / Q000382:microbiology / Q000662:veterinary*; D016977:Actinobacillus pleuropneumoniae / Q000472:pathogenicity*; D000818:Animals; D009243:NAD / Q000378:metabolism*; D011001:Pleuropneumonia / Q000382:microbiology / Q000662:veterinary*; D013047:Specific Pathogen-Free Organisms; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology*; D014774:Virulence
chemical_list: D009243:NAD