Mesangial expression of intercellular adhesion molecule-1 in primary glomerulosclerosis.
Frozen sections of renal biopsy specimens from eight patients with primary focal segmental glomerulosclerosis (FSGS) and 10 patients with membranous nephropathy (MN) were stained in immuno-peroxidase with the intercellular adhesion molecule-1 (ICAM-1) monoclonal antibody (MoAb), CL203.4. ICAM-1 was expressed by mesangial cells in six patients with FSGS. On the other hand, ICAM-1 was not detected in mesangial cells in patients with MN or in the non-affected portion of tumoral kidneys used to control normal renal expression of ICAM-1. De novo mesangial expression of ICAM-1 in FSGS suggests that sclerosis results from an inflammatory process, possibly associated with local release of cytokines.
Dal Canton
A
A
Cattedra di Nefrologia, Università di Catanzaro, Italy.
Fuiano
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G
Sepe
V
V
Caglioti
A
A
Ferrone
S
S
D000911:Antibodies, Monoclonal; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D005920:Glomerular Mesangium / Q000378:metabolism*; D005923:Glomerulosclerosis, Focal Segmental / Q000378:metabolism*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D007668:Kidney / Q000378:metabolism; D012016:Reference Values; D013194:Staining and Labeling; D014018:Tissue Distribution
D000911:Antibodies, Monoclonal; D015815:Cell Adhesion Molecules; D018799:Intercellular Adhesion Molecule-1