Local sequence dependence of rate of base replacement in mammals.
I have analysed the local sequence context of base replacement changes in 78 processed pseudogenes. Transversions occur more often than transitions in a ratio of 3.37 to 1, and G:C is replaced 1.4 times more frequently than A:T. In addition, the bases to the 5' and 3' of the mutating base also influence the rate at which bases change, purine:pyrimidine and pyrimidine:purine pairs changing 1.2 times as fast as purine:purine and pyrimidine:pyrimidine pairs. I discuss implications of this for the mechanism of DNA polymerization in mammals.
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PA Consulting Group, Cambridge Laboratory, Melbourn, Royston, Herts, Great Britain.
D000818:Animals; D001482:Base Composition; D002417:Cattle; D005796:Genes; D006801:Humans; D008322:Mammals / Q000235:genetics*; D051379:Mice; D009154:Mutation; D011544:Pseudogenes; D051381:Rats