[Use of 2,4-dinitrophenol for immunosuppressive action on the recipient in implantation of fetal organs in mice].
In experiments performed on 118 white mice and 10 laboratory rats, it was shown that cutaneous application of 2,4-dinitrophenol microdoses once a week around the sites of fetal organ implantation leads to a significant prolongation of the implant life with minimal trouble for the recipient's health. The maximal effect was reached with 10(-3) M concentration of DNP, the applications beginning 2-3 weeks before fetal pancreas implantations.
Bulava
K M
KM
Kulik
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VP
D019297:2,4-Dinitrophenol; D000818:Animals; D004140:Dinitrophenols / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D016332:Fetal Tissue Transplantation; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007421:Intestine, Small / Q000196:embryology / Q000637:transplantation*; D008297:Male; D051379:Mice; D010179:Pancreas / Q000196:embryology; D016035:Pancreas Transplantation; D051381:Rats; D013997:Time Factors; D016042:Transplantation, Heterotopic
D004140:Dinitrophenols; D007166:Immunosuppressive Agents; D019297:2,4-Dinitrophenol