Central role for differential gene expression in mammalian hibernation.
Mammalian hibernators experience dramatic reductions in body temperature, metabolic rate, respiratory rate, and heart rate during hibernation. These changes are precisely controlled and reversible with only internally driven mechanisms, suggesting specific biochemical regulation. We present a model that integrates our observations of differential liver gene expression during preparation for, and maintenance of, the hibernating state, with the known phylogenetic interspersion of hibernating species in several major mammalian lineages. This model predicts a major role for the differential expression of existing mammalian genes in the biochemical regulation of hibernation.
Srere
H K
HK
University of Colorado Health Sciences Center, Department of Cellular and Structural Biology, Denver 80262.
Wang
L C
LC
Martin
S L
SL
D000818:Animals; D001143:Arousal; D001798:Blood Proteins / Q000378:metabolism; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D015870:Gene Expression; D015723:Gene Library; D006605:Hibernation / Q000502:physiology*; D008099:Liver / Q000502:physiology; D008954:Models, Biological; D010507:Periodicity; D010802:Phylogeny; D011061:Poly A / Q000235:genetics / Q000302:isolation & purification; D012313:RNA / Q000235:genetics / Q000302:isolation & purification; D012333:RNA, Messenger; D012589:Sciuridae / Q000235:genetics / Q000502:physiology*; D012709:Serum Albumin / Q000378:metabolism; D013045:Species Specificity
D001798:Blood Proteins; D012333:RNA, Messenger; D012709:Serum Albumin; D011061:Poly A; D012313:RNA; D004247:DNA