Temporal association of marrow eosinophilia with inversion of chromosome 16 in recurrent blast crises of chronic myelogenous leukemia.
We report a patient with Ph+ chronic myelogenous leukemia (CML) whose recurrent blast crises were associated with marrow eosinophilia and inv(16). After intensive chemotherapy, for each blast crisis, the patient reentered chronic phase with disappearance of both the inv(16) and the eosinophilia.
Evers
J P
JP
Department of Medicine, Georgetown University Medical Center, Washington, D.C.
Bagg
A
A
Himoe
E
E
Zwiebel
J A
JA
Jacobson
R J
RJ
D000328:Adult; D001752:Blast Crisis; D002869:Chromosome Aberrations; D002885:Chromosomes, Human, Pair 16; D004802:Eosinophilia / Q000150:complications*; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000235:genetics*; D008297:Male