Dopamine receptor agonists and antagonists enhance ATP-activated currents.
The effects of dopamine and related compounds on ATP-activated channels were investigated in pheochromocytoma PC12 cells. Dopamine (10 microM) enhanced an inward current activated by 100 microM ATP. A similar enhancement of the ATP-activated current was observed with apomorphine (10 microM), a non-selective dopamine receptor agonist, with (+)-SKF-38393 (10 microM), a selective dopamine D1 receptor agonist, and with (-)-quinpirole (10 microM), a selective dopamine D2 receptor agonist. Moreover, (+)-SCH-23390 (30 microM), a dopamine D1 receptor antagonist, and (-)-sulpiride (30 microM), a dopamine D2 receptor antagonist, also enhanced the ATP-activated current. The results suggest that ATP-activated channels are modulated by dopaminergic mechanisms, and that this modulation cannot be attributed to any single class of dopamine receptors.
Inoue
K
K
Division of Pharmacology, National Institute of Hygienic Sciences, Tokyo, Japan.
Nakazawa
K
K
Watano
T
T
Ohara-Imaizumi
M
M
Fujimori
K
K
Takanaka
A
A
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D004298:Dopamine / Q000494:pharmacology; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism*; D016716:PC12 Cells / Q000187:drug effects; D011954:Receptors, Dopamine / Q000187:drug effects*; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors / Q000187:drug effects; D017448:Receptors, Dopamine D2 / Q000187:drug effects
D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D007473:Ion Channels; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D000255:Adenosine Triphosphate; D004298:Dopamine