title: Effect of various polyamino acids and D- and L-amino acids on the blood fibrinolytic system.
abstract: 1. Comparative additional effects of 24 commercially obtained amino acids and their derivatives were studied by the whole blood clot lysis time (WBCLT) method. D-Arg and L-Lys (greater than 50 micrograms/ml) activated the fibrinolytic system, and poly-L-Glu (mol. wt 6000-90,000) (less than 50 micrograms/ml) were less effective. 2. Poly-L-Arg, poly-L-Lys and poly-(Lys-Ala-Glu-Tyr) accelerated the TPA inhibition in the presence of human plasma. 3. For in vivo experiments, 5 mg of poly-L-Glu were given intravenously to 10 rats. 4. The shortening of WBCLT and elevation of EFA (P less than 0.01) were found after 1 hr administration. 5. The main enzymes which increased in plasma were proved to be the endogenous plasminogen activators with mol. wt higher than 70,000, by zymography.
authors.affiliation: Department of Nutrition and Food Science, Okayama Prefectural College, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Sumi
authors.forename: K
authors.initials: K
authors.lastname: Kawabe
authors.forename: N
authors.initials: N
authors.lastname: Nakajima
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D011099:Polyglutamic Acid / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D010455:Peptides; D011099:Polyglutamic Acid