Immunohistochemical localisation of substance P in human parotid gland.
Based on the clinical observation that pain is experienced during parotid gland surgery under local anaesthesia, the presence of the sensory neuropeptide substance P (SP) was sought. Using a polyclonal antibody, the presence of SP was demonstrated by an indirect immunofluorescence technique, with rat parotid gland and spinal cord serving as controls. SP-containing neuronal elements occurred around acini, blood vessels and ducts. It is suggested that some of the SP-immunoreactive elements are the unmyelinated and thinly myelinated small diameter (A delta and C) fibres, which are regarded as the peripheral receptors for nociceptive information.
Whitley
B D
BD
Department of Oral Medicine, Faculty of Dentistry University of Otago, Dunedin, New Zealand.
Ferguson
J W
JW
Harris
A J
AJ
Kardos
T B
TB
D000273:Adipose Tissue / Q000294:innervation; D000328:Adult; D000818:Animals; D001808:Blood Vessels / Q000294:innervation; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D009412:Nerve Fibers / Q000737:chemistry*; D010306:Parotid Gland / Q000098:blood supply / Q000737:chemistry / Q000294:innervation*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000737:chemistry; D013373:Substance P / Q000032:analysis*; D013376:Substantia Gelatinosa / Q000737:chemistry
D013373:Substance P