title: Synthesis and pharmacological study of some 3-(isoxazol-5-yl)-quinazolin-4(3H)-ones.
abstract: A number of new 3-(isoxazol-5-yl)-quinazolin-4(3H)-ones was prepared and tested, together a few analogues previously obtained, for their analgesic, antipyretic and antiinflammatory activities, as well as for their acute toxicity and ulcerogenic effects. In the carrageenan rat foot edema model one of the tested compounds showed activity and LD50 comparable to that of ASA, but the ulceration index approximated zero value.
authors.affiliation: Dipartimento di Chimica e Technologie Farmaceutiche, Università di Palermo, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Plescia
authors.forename: G
authors.initials: G
authors.lastname: Daidone
authors.forename: D
authors.initials: D
authors.lastname: Raffa
authors.forename: M L
authors.initials: ML
authors.lastname: Bajardi
authors.forename: A
authors.initials: A
authors.lastname: Caruso
authors.forename: V
authors.initials: V
authors.lastname: Cutuli
authors.forename: M
authors.initials: M
authors.lastname: Amico-Roxas
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D008297:Male; D051379:Mice; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007555:Isoxazoles; D011799:Quinazolines