[Pharmacokinetic study of pseudohainanensine with deuteriumlabeled analogue as internal standard].
Pseudohainanensine (HH08) is a synthetic compound which is active against L-1210. In order to study the pharmacokinetic characteristics of this compound in rats, 3', 4'-dideuteropseudohainanensine (DH08) was synthesized and used as internal standard in GC-MS determination for quantitative analysis of alkaloid HH08 in the blood of rats that had been given HH08 at a dosage of 10 mg/kg intravenously. Experiments demonstrated that the detection limit of HH08 was 3 micrograms/ml and the peak concentration in the blood was 13.1 +/- 0.2 micrograms/ml after a single intravenous injection (one min. after injection). The biological half life time can be divided into two phases; the fast phase (alpha) 2.61 min, and the slow phase (beta) 42.59 min. Two hours after the injection no drug could be detected in the blood.
Gu
Q M
QM
Institute of Materia Medica, CAMS. Beijing.
D000470:Alkaloids / Q000493:pharmacokinetics*; D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D008401:Gas Chromatography-Mass Spectrometry; D051381:Rats
D000470:Alkaloids; D000970:Antineoplastic Agents; C077431:pseudohainanensine