title: Suppressing effect of vanillin on chromosome aberrations that occur spontaneously or are induced by mitomycin C in the germ cell line of Drosophila melanogaster.
abstract: In order to investigate the anticlastogenic effect of vanillin on ring-X loss, D. melanogaster females exposed to different vanillin concentrations were crossed with non-treated, MMC- or MMS-treated males. The results obtained with this in vivo investigation showed a significant inhibition of vanillin in the frequencies of spontaneous ring-X loss--59, 56, 38 and 36%--at the different concentrations used. In addition, vanillin treatment caused a significant suppression of MMC-induced ring-X loss. This decrease was observed only in the first 3 days after the interruption of vanillin treatment and at the concentrations of 0.5 and 1% of this flavoring agent. In contrast, vanillin did not show any effect on chromosome loss provoked by MMS. Therefore, the ring-X loss-decreasing effect of vanillin seemed to depend on the quality of DNA lesions and consequently on a specific enzymatic repair process present in the oocytes of D. melanogaster.
authors.affiliation: Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: H H
authors.initials: HH
authors.lastname: de Andrade
authors.forename: J H
authors.initials: JH
authors.lastname: Santos
authors.forename: M C
authors.initials: MC
authors.lastname: Gimmler-Luz
authors.forename: M J
authors.initials: MJ
authors.lastname: Correa
authors.forename: M
authors.initials: M
authors.lastname: Lehmann
authors.forename: M L
authors.initials: ML
authors.lastname: Reguly
mesh_terms: D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001547:Benzaldehydes / Q000494:pharmacology*; D016009:Chi-Square Distribution; D002872:Chromosome Deletion; D004260:DNA Repair; D004331:Drosophila melanogaster / Q000235:genetics; D005260:Female; D008297:Male; D016685:Mitomycin; D009152:Mutagenicity Tests; D009865:Oocytes / Q000187:drug effects; D012303:Ring Chromosomes; D013094:Spermatozoa / Q000187:drug effects; D014960:X Chromosome / Q000187:drug effects
chemical_list: D016587:Antimutagenic Agents; D001547:Benzaldehydes; D016685:Mitomycin; C100058:vanillin