Depressed interferon synthesis in skin fibroblasts from lung cancer patients.
Skin fibroblast cell cultures, derived from male adult lung cancer patients, an adult control population, and a newborn population were examined for their susceptibility to transformation with Kirsten murine sarcoma virus and their ability to respond to an interferon inducer (poly I.poly C). An association between sensitivity to viral transformation and induction of interferon was observed. Cultures derived from lung cancer patients demonstrated an increased sensitivity to virus transformation and a decreased ability to respond to interferon induction as compared with age-matched controls and newborns.
Winters
A L
AL
Department of Microbiology, University of Alabama, University 35486.
Leach
M F
MF
Horton
E J
EJ
Frankel
J W
JW
D000328:Adult; D000368:Aged; D002460:Cell Line; D002472:Cell Transformation, Viral / Q000502:physiology; D002478:Cells, Cultured; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007372:Interferons / Q000032:analysis / Q000096:biosynthesis*; D007708:Kirsten murine sarcoma virus / Q000235:genetics; D008175:Lung Neoplasms / Q000276:immunology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000378:metabolism*
D007372:Interferons