Biology of restenosis and therapeutic approach.
Numerous attempts have been made to prevent restenosis after successful transluminal dilation of an atherosclerotic vessel using a variety of pharmacologic and mechanical approaches. This article reviews the pathobiology of the restenosis process, offers a hypothesis as to its cause, reviews attempts to modify the process, and outlines therapeutic approaches to future treatment.
Nicolini
F A
FA
Department of Medicine, University of Florida College of Medicine, Gainesville.
Pepine
C J
CJ
D000800:Angioplasty, Balloon; D000818:Animals; D001161:Arteriosclerosis / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D001695:Biology; D006801:Humans; D012008:Recurrence