Large-cell "mixed-phenotype" lymphoma in AIDS. Identification of a CD5-expressing subset of B-cell non-Hodgkin's lymphoma.
We have characterized cells from an AIDS-associated non-Hodgkin's lymphoma (NHL). We found a malignant CD5+ B cell (approximately three-fourths of cells), with the balance of cells comprised of T cells having an activated phenotype. The lymphoma was unusual, in that all cells bear "T-lineage" markers, CD3 and CD5, and "B-lineage" markers, CD19 and CD20. Thus, conventional immunohistologic techniques were insufficient to type this mixture of cells; single-cell analysis was required. These "mixed-phenotype" lymphomas may occur frequently in AIDS-associated NHL. Our results show striking similarity to those obtained in the analysis of certain murine CD5+ B-cell lymphomas, suggesting that the study of lymphomagenesis in the mouse may aid in the understanding of AIDS-associated NHL.
Mercolino
T J
TJ
Becton Dickinson Immunocytometry Systems, San Jose, California 95131.
Herndier
B
B
Nolan
T J
TJ
McGrath
M S
MS
D015703:Antigens, CD / Q000032:analysis*; D016175:B-Lymphocyte Subsets / Q000276:immunology* / Q000473:pathology; D001706:Biopsy; D018956:CD5 Antigens; D006679:HIV Seropositivity; D006801:Humans; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D016483:Lymphoma, AIDS-Related / Q000276:immunology* / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010641:Phenotype
D015703:Antigens, CD; D018956:CD5 Antigens