Ivermectin treatment of naturally acquired and experimentally induced Strongyloides stercoralis infections in dogs.
Treatment of Strongyloides stercoralis infection was investigated in 2 dogs with naturally acquired, chronic-active infections, and in 3 dogs with corticosteroid-enhanced, experimentally induced hyperinfections. A single oral dose of ivermectin was given to naturally infected (200 micrograms/kg of body weight) and experimentally infected (800 micrograms/kg) dogs. Five dogs with experimental hyperinfections served as controls. Dogs with naturally acquired infections ceased to shed first-stage larvae in the feces 1 week after treatment, but 1 dog had recrudescence and required a second dose. Ivermectin was 100% effective in removing adult S stercoralis from the intestinal tract of the experimentally infected dogs, but it was not effective in removing third-stage larvae from parenteral sites. Ivermectin-treated dogs had few intestinal parasites of any stage, whereas at necropsy, 4 of 5 experimentally infected dogs not treated had massive infections (greater than 100,000 adults, greater than 92,000 larvae) in the intestinal tract, and 3 of 5 had larvae (greater than 2,500) in parenteral sites.
Mansfield
L S
LS
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104.
Schad
G A
GA
D000284:Administration, Oral; D000818:Animals; D002908:Chronic Disease; D004283:Dog Diseases / Q000188:drug therapy* / Q000469:parasitology; D004285:Dogs; D005243:Feces / Q000469:parasitology; D005260:Female; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D007422:Intestines / Q000469:parasitology; D007559:Ivermectin / Q000008:administration & dosage / Q000627:therapeutic use*; D007814:Larva; D008297:Male; D012867:Skin / Q000469:parasitology; D017171:Strongyloides stercoralis / Q000187:drug effects* / Q000302:isolation & purification; D013322:Strongyloidiasis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*
D007559:Ivermectin