Adrenal- and ovarian-vein steroids and LH response to GnRH in two patients with virilizing adrenocortical adenoma studied by selective catheterizations.
Two women with androgen-secreting adrenal adenomas were studied by selective adrenal- and ovarian-vein catheterization. Blood samples were collected for determination of testosterone, androstenedione, dehydroepiandrosterone sulfate and cortisol. In a preoperative stimulation test with gonadotropin-releasing hormone, the response of luteinizing hormone was enhanced in both subjects. In catheterization studies, the venous gradients for the hormones were not diagnostic for the source of hyperandrogenism in either of the patients.
Ruutiainen
K
K
Department of Obstetrics and Gynecology, Turku University Central Hospital, Finland.
Satokari
K
K
Anttila
L
L
Erkkola
R
R
D000236:Adenoma / Q000097:blood* / Q000378:metabolism; D000306:Adrenal Cortex Neoplasms / Q000097:blood* / Q000378:metabolism; D000311:Adrenal Glands / Q000098:blood supply*; D000328:Adult; D000728:Androgens / Q000378:metabolism*; D000738:Androsterone / Q000097:blood; D002404:Catheterization; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate; D005260:Female; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood*; D010053:Ovary / Q000098:blood supply*; D013739:Testosterone / Q000097:blood; D014680:Veins
D000728:Androgens; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate; D007986:Luteinizing Hormone; D000738:Androsterone; D006854:Hydrocortisone