title: [Effectiveness of estriol depot vaginal suppositories in postmenopausal women with urogenital climacteric manifestations].
abstract: In this study, 43 postmenopausal patients with urogenital complaints such as vaginal dryness, incontinence, or bleeding with intercourse were treated with weekly applications of Orthogynest vaginal estriol suppositories in a new depot form. A marked increase in the vaginal epithelium (A. Schmitt score) and a significant decrease in symptoms due to vaginal atrophy were noted. The depot form allows for decreased dosing frequency, leading to improved compliance. Systemic symptoms, such as hot flashes and emotional lability, were also noted to respond to the Orthogynest suppositories.
authors.affiliation: Thurgauisches Kantonsspital, Frauenfeld.
authors.forename: O R
authors.initials: OR
authors.lastname: Köchli
authors.forename: G
authors.initials: G
authors.lastname: Schär
authors.forename: B
authors.initials: B
authors.lastname: Beck
authors.forename: J
authors.initials: J
authors.lastname: Benz
mesh_terms: D000282:Administration, Intravaginal; D002979:Climacteric / Q000187:drug effects*; D003692:Delayed-Action Preparations; D004964:Estriol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D014549:Urinary Incontinence / Q000188:drug therapy*
chemical_list: D003692:Delayed-Action Preparations; D004964:Estriol