Fibroblast growth factor injected in cerebral ventricles does not decrease mean arterial blood pressure.
Intracerebroventricular injections of acidic fibroblast growth factor (aFGF) in rats did not elicit any change in the mean arterial blood pressure, and also did not appreciably affect the hypotensive effect of intravenous injections of aFGF. These observations are of general clinical interest, since such effects could constitute important drawbacks for the therapeutic applications of FGF.
Cuevas
P
P
Histology Department, Hospital Ramóm y Cajal, Madrid, Spain.
Carceller
F
F
Muñoz-Willery
I
I
Gimenez-Gallego
G
G
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D016220:Fibroblast Growth Factor 1 / Q000008:administration & dosage*; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000008:administration & dosage
D011994:Recombinant Proteins; D016220:Fibroblast Growth Factor 1