Haloperidol-induced increase in neuropeptide Y immunoreactivity in the locus coeruleus of the rat brain.
The effect of haloperidol, a dopamine (preferably D2) receptor blocking agent on neuropeptide Y immunoreactivity was studied immunohistochemically in neurons of the locus coeruleus and striatum of rat brain. It was found that haloperidol given four times (5 and 2.5 mg/kg, i.p.) induced, after 24 h, a significant increase in the level of neuropeptide Y immunoreactivity in the locus coeruleus but not in the striatum. No changes in neuropeptide Y immunoreactivity in studied structures were observed after alpha-adrenergic receptor blocking agent phenoxybenzamine or serotonin-synthesis inhibitor D,L-p-chlorophenylalanine. The results suggest that the content of neuropeptide Y-immunoreactive material in nerve cell bodies of the locus coeruleus is inhibitorally controlled by monoaminergic (may be dopaminergic D2) receptors.
Smiałowska
M
M
Laboratory of Neurobiology, Polish Academy of Sciences, Kraków.
Legutko
B
B
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D010134:Fenclonine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology*; D007150:Immunohistochemistry; D008125:Locus Coeruleus / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D009478:Neuropeptide Y / Q000276:immunology / Q000378:metabolism*; D010643:Phenoxybenzamine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D009478:Neuropeptide Y; D010643:Phenoxybenzamine; D006220:Haloperidol; D010134:Fenclonine