title: Brain implants in man do not break down the blood-brain barrier to dopamine and domperidone.
abstract: We have evaluated the blood-brain barrier (BBB) in 8 Parkinsonian patients before and after stereotactic implantation of foetal mesencephalon (STIM) and one patient with an adrenal medullary implant. Parenteral administration of dopamine did not reverse Parkinsonism pre-operatively or at 5 days, 1, 2, 3, 4 months and 1 year post-operatively. Apomorphine and domperidone reversed Parkinsonism and produced dyskinesia in all patients pre- and post-operatively. We conclude that the BBB remains intact to dopamine following implantation.
authors.affiliation: Department of Neurosurgery, University of Birmingham, Midland Centre for Neurosurgery and Neurology, Smethwick, Warley, UK.
authors.forename: C G
authors.initials: CG
authors.lastname: Clough
authors.forename: E R
authors.initials: ER
authors.lastname: Hitchcock
authors.forename: R C
authors.initials: RC
authors.lastname: Hughes
authors.forename: B T
authors.initials: BT
authors.lastname: Henderson
authors.forename: B G
authors.initials: BG
authors.lastname: Kenny
mesh_terms: D000328:Adult; D000368:Aged; D001058:Apomorphine / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism*; D004294:Domperidone / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D004298:Dopamine / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D004343:Drug Implants; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000378:metabolism
chemical_list: D004343:Drug Implants; D004294:Domperidone; D001058:Apomorphine; D004298:Dopamine