[Role of the hypothalamo-hypophyseal neurosecretory system in the accomplishment of the antistress effect of substance P].
Light and electron microscopy and spectrophotometry were employed in study of the morphofunctional condition of the hypothalamo-hypophyseal neurosecretory system (HHNS) of intact rats after exposure to stress in injection of substance P. Injection of 12.5 mcg/100g of substance P decelerates the outflow of the neurosecretory substance in intact animals and inhibits the processes of biosynthesis in the neurocytes of the hypothalamic supraoptic nucleus. Injection of substance P prior to exposure of the organism to the stress effects leads to diminution of the HHNS response of them and prevents the development of dystrophic changes in the gastric mucosa.
Kozhevnikova
L A
LA
Kosenko
A F
AF
Drozdovich
I I
II
D000818:Animals; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000503:physiopathology*; D013373:Substance P / Q000502:physiology*
D013373:Substance P