Synthesis, characterization and biodistribution studies of a neutral-lipophilic Tc-99m N3S2 chelate.
Diaminedithiols (DADT) are known to form neutral-lipophilic complexes with 99mTc in aqueous solutions, where they are readily formed in high yields and demonstrate excellent stability. A new triaminedithiol (TADT) ligand was synthesized, characterized and shown to form a neutral-lipophilic 99mTc-chelate. The biodistribution of this 99mTc chelate in rats showed that its uptake in brain or heart following i.v. injection of the 99mTc chelate was low, but activity taken up was retained over a long period of time. The in vivo and in vitro properties of this chelate indicate the possibility that chemical modification of this TADT ligand may produce ligand systems that form 99mTc chelates with suitable diagnostic properties.
Singh
P R
PR
Department of Radiology, Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65211.
Corlija
M
M
Troutner
D E
DE
Ketring
A R
AR
Volkert
W A
WA
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D002854:Chromatography, Paper; D002855:Chromatography, Thin Layer; D004588:Electrophoresis, Cellulose Acetate; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D011437:Propylamines / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D013667:Technetium / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D007202:Indicators and Reagents; D015609:Organotechnetium Compounds; D011437:Propylamines; C077317:technetium Tc 99m 2,2,8,14,14-pentamethyl-4,8,12-triazadodecanedithiol; D013667:Technetium