Vermixocins A and B, two novel metabolites from Penicillium vermiculatum.
Vermixocins A and B, 3-(1'-hydroxy-3'-methylbutyl)- and 3-(1'-acetoxy-3'-methylbutyl)-11-hydroxy-4-methoxy-9-methyl-5H,7H- dibenzo[c,f][1,5]dioxocin-5-one, respectively, were isolated from the mycelium of Penicillium vermiculatum. Both metabolites showed cytotoxic effects on lympholeukemia cells P388.
Proksa
B
B
Institute of Chemistry, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
Uhrín
D
D
Adamcová
J
J
Fuska
J
J
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000302:isolation & purification; D006575:Heterocyclic Compounds, 3-Ring; D007941:Leukemia P388 / Q000378:metabolism; D051379:Mice; D010407:Penicillium / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic; D006571:Heterocyclic Compounds; D006575:Heterocyclic Compounds, 3-Ring; C068086:purpactin A; C077329:vermixocin A