title: Influence of cefodizime on the reagibility of human leukocytes.
abstract: Cefodizime was evaluated for its effect on a number of parameters of leukocyte function in humans. Four healthy volunteers received 2 g i.v. b.i.d. for seven days. Leukocyte activity was measured before, during and after treatment. Using opsonized zymosan as a stimulant, no effect on the respiratory burst of granulocytes was observed. It was found, however, that the lymphocytes in three of the four subjects showed significantly more marked proliferation rates in the mixed lymphocyte reaction after administration of cefodizime than at baseline. The stimulation indices subsequently returned to normal. This pilot study therefore demonstrated that cefodizime has biological response modifying properties in healthy humans.
authors.affiliation: Pharma Research Antiinfectives, Hoechst AG, Brüningstr., Frankfurt/Main, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Limbert
authors.forename: H
authors.initials: H
authors.lastname: Müllner
authors.forename: P M
authors.initials: PM
authors.lastname: Shah
mesh_terms: D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology*; D007962:Leukocytes / Q000187:drug effects* / Q000502:physiology; D008163:Luminescent Measurements; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D010587:Phagocytosis / Q000187:drug effects
chemical_list: D007155:Immunologic Factors; D002439:Cefotaxime; C033356:cefodizime