title: Determination of the absolute configuration of the active amlodipine enantiomer as (-)-S: a correction.
abstract: The active (-) enantiomer of amlodipine was originally reported to have R configuration. This does not concur with other 1,4-dihydropyridines with known absolute configuration. This configuration has now been determined by X-ray structural analysis using (1S)-camphanic acid and (S)-2-methoxy-2-phenylethanol as chiral probes. Both determinations gave the S configuration for the amlodipine (-) enantiomer with the greater Ca-antagonistic activity.
authors.affiliation: Bayer AG, Pharma Research Center, Wuppertal, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Goldmann
authors.forename: J
authors.initials: J
authors.lastname: Stoltefuss
authors.forename: L
authors.initials: L
authors.lastname: Born
mesh_terms: D017311:Amlodipine; D008968:Molecular Conformation; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000737:chemistry; D013237:Stereoisomerism; D014961:X-Ray Diffraction
chemical_list: D017311:Amlodipine; D009543:Nifedipine