Extracorporeal membrane oxygenation in lambs through umbilical vessel perfusion: cardiac and hepatic complications.
Twin lambs were delivered by ceasarean section near term, aralyzed, sedated and randomly assigned to either mechanical ventilation or umbilical arteriovenous ECMO for 48 hours. Umbilical arteriovenous ECMO provided adequate gas exchange with minimal or no ventilation of the native lungs. However, at autopsy, animals treated with umbilical ECMO showed right heart dilation and liver necrosis or hemorrhage compared to their twins treated with mechanical ventilation.
Bui
K C
KC
Division of Neonatology, Children's Hospital, Los Angeles, Calif 90027.
Humphries
B
B
Kitagawa
H
H
Kosi
M
M
Dorio
R
R
Lew
C
C
Atkinson
J
J
Platzker
A
A
D000818:Animals; D000831:Animals, Newborn; D006332:Cardiomegaly / Q000209:etiology; D004195:Disease Models, Animal; D015199:Extracorporeal Membrane Oxygenation / Q000009:adverse effects / Q000379:methods*; D005240:Feasibility Studies; D006470:Hemorrhage / Q000209:etiology; D008107:Liver Diseases / Q000209:etiology; D010865:Pilot Projects; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000628:therapy*; D012756:Sheep; D014427:Twins; D014469:Umbilical Arteries; D014471:Umbilical Veins