Neutrophil chemiluminescence following exposure to formaldehyde in healthy subjects and in patients with contact dermatitis.
13 formaldehyde-sensitive contact dermatitis patients and 5 healthy subjects were exposed to formaldehyde (FM) at a concentration 0.5 mg/m3, in an exposure chamber for 2 hours. There was no significant decrease of the ventilatory parameters either in healthy subjects or in contact dermatitis patients following the exposure Bronchial hyperreactivity to histamine (PC20) increased in one healthy and two patients with contact dermatitis. Neutrophils were isolated from whole venous blood before the test and 30 minutes and 24 hours after the exposure. All subjects with allergic contact dermatitis had chemiluminescence higher before the FM provocation in a comparison with the healthy ones. It increased significantly 30 minutes post the exposure and was much higher 24 hours after the exposure in the comparison with the neutrophil chemiluminescence before the test.
Górski
P
P
Department of Occupational Diseases, Institute of Occupational Medicine, Lodz, Poland.
Tarkowski
M
M
Krakowiak
A
A
Kieć-Swierczyńska
M
M
D000328:Adult; D000485:Allergens; D001273:Atmosphere Exposure Chambers; D003877:Dermatitis, Contact / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D009783:Dermatitis, Occupational / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D005260:Female; D005557:Formaldehyde / Q000009:adverse effects / Q000494:pharmacology*; D006632:Histamine; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007428:Intradermal Tests; D008163:Luminescent Measurements; D008297:Male; D009504:Neutrophils / Q000187:drug effects*; D016273:Occupational Exposure; D010328:Patch Tests; D016897:Respiratory Burst / Q000187:drug effects*; D012129:Respiratory Function Tests; D013997:Time Factors
D000485:Allergens; D005557:Formaldehyde; D007073:Immunoglobulin E; D006632:Histamine