title: Research on heterocyclic compounds, XXIX. Synthesis and antiinflammatory activity of imidazo[1,2-a]pyrazine derivatives.
abstract: The reaction in anhydrous ethanol of some substituted 2-aminopyrazines with ethyl 2-benzoyl-2-bromoacetate or with ethyl 3-bromo-4-oxopentanoate afforded a group of ethyl 2-phenylimidazo[1,2-a]pyrazine-3-carboxylates and a group of ethyl 2-methylimidazo[1,2-a]pyrazine-3-acetates, respectively. The corresponding acids obtained via alkaline hydrolysis were subjected to pharmacological testing in vivo in order to evaluate their antiinflammatory activity.
authors.affiliation: Dipartimento di Chimica Farmaceutica e Tossicologica, Facoltà di Farmacia Università di Napoli Federico II.
authors.forename: E
authors.initials: E
authors.lastname: Abignente
authors.forename: P
authors.initials: P
authors.lastname: De Caprariis
authors.forename: M G
authors.initials: MG
authors.lastname: Rimoli
authors.forename: F
authors.initials: F
authors.lastname: Capasso
authors.forename: G
authors.initials: G
authors.lastname: Autore
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000473:pathology; D011719:Pyrazines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011719:Pyrazines; D002351:Carrageenan