title: M-BCR breakpoint location does not predict survival in Philadelphia chromosome-positive chronic myeloid leukemia.
abstract: BACKGROUND
  Some reports in the recent literature have shown that the site of molecular rearrangement within the M-BCR area may have a prognostic value in Ph1 + CML patients. A number of studies have, however, failed to demonstrate this finding. Here we report the molecular rearrangements of 107 patients and their clinical follow-up.
  
  
  METHODS
  Localization of the breakpoints was determined according to conventional criteria, after digestion with 2 to 4 restriction endonucleases and hybridization with 1 or 2 molecular probes.
  
  
  RESULTS
  Sixty two patients were rearranged in the 5' area and 45 in the 3' area: there was no difference between the survival curves of the two groups, at least not after 3 years of follow-up.
  
  
  CONCLUSIONS
  The site of the breakpoint within the M-BCR has no prognostic significance in our series.
authors.affiliation: Centro di Genetica Oncologica, Università di Bologna, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Zaccaria
authors.forename: G
authors.initials: G
authors.lastname: Martinelli
authors.forename: M
authors.initials: M
authors.lastname: Buzzi
authors.forename: E
authors.initials: E
authors.lastname: Zuffa
authors.forename: M D
authors.initials: MD
authors.lastname: Zamagni
authors.forename: N
authors.initials: N
authors.lastname: Testoni
authors.forename: D
authors.initials: D
authors.lastname: Russo
authors.forename: A
authors.initials: A
authors.lastname: Guerrasio
authors.forename: G
authors.initials: G
authors.lastname: Saglio
authors.forename: S
authors.initials: S
authors.lastname: Tura
mesh_terms: D000328:Adult; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D015321:Gene Rearrangement; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000401:mortality; D015993:Life Tables; D008297:Male; D008875:Middle Aged; D010677:Philadelphia Chromosome; D011379:Prognosis; D015996:Survival Rate
chemical_list: D016044:Fusion Proteins, bcr-abl