Permeability of insulin entrapped in liposome through the nasal mucosa of rabbits.
The permeability of liposome entrapping insulin through the nasal mucosa of rabbit has been studied and compared with the permeability of insulin solution with or without pretreatment by sodium glycocholate (GC). Insulin entrapped in liposome was not detected in the receiver cell using the diffusion cells with the nasal mucosa. On the other hand, permeability of insulin entrapped in liposome increased after the pretreatment of GC. The phospholipids which result from liposomes, were not observed in the receiver. Also, the GC remaining in the nasal mucosa was measured. Considering the mechanism of permeation of insulin entrapped in liposome through the nasal mucosa, the GC remaining in the nasal mucosa may cause the lysis of liposomes.
Maitani
Y
Y
Department of Pharmaceutics, Hoshi University, Tokyo, Japan.
Asano
S
S
Takahashi
S
S
Nakagaki
M
M
Nagai
T
T
D000281:Administration, Intranasal; D000818:Animals; D007328:Insulin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008081:Liposomes; D009297:Nasal Mucosa / Q000378:metabolism*; D010539:Permeability; D011817:Rabbits
D007328:Insulin; D008081:Liposomes