title: Hyperfractionated radiotherapy and polychemotherapy in brain stem tumors in children.
abstract: Between October 1989 and January 1991 five children with brain stem tumors were treated with sequential chemo- and radiotherapy. The polychemotherapy consisted of procarbazine, ifosfamide, etoposide, methotrexate, cisplatin and cytosine arabinoside. Locally, hyperfractionated radiotherapy was delivered at a total dose of 63.8 Gy (1.1 Gy twice daily, 10 fractions per week). After a median observation time of 11.8 (range 4-23) months from diagnosis three children are alive and without evidence of tumor progression. Two patients died from tumor progression 11 and 16 months respectively after initiation of therapy.
authors.affiliation: Abteilung für Strahlentherapie, Radiologische Universitätsklinik, Graz, Austria.
authors.forename: B
authors.initials: B
authors.lastname: Pakisch
authors.forename: C
authors.initials: C
authors.lastname: Urban
authors.forename: I
authors.initials: I
authors.lastname: Slavc
authors.forename: E
authors.initials: E
authors.lastname: Poier
authors.forename: G
authors.initials: G
authors.lastname: Stücklschweiger
authors.forename: R
authors.initials: R
authors.lastname: Oberbauer
authors.forename: M
authors.initials: M
authors.lastname: Mokry
authors.forename: J
authors.initials: J
authors.lastname: Poschauko
authors.forename: J
authors.initials: J
authors.lastname: Hammer
authors.forename: H
authors.initials: H
authors.lastname: Leitner
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003561:Cytarabine / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D011149:Pons; D011855:Radiodermatitis / Q000209:etiology; D011879:Radiotherapy Dosage; D012074:Remission Induction; D015996:Survival Rate; D013788:Thalamus
chemical_list: D003561:Cytarabine; D008727:Methotrexate