title: Teicoplanin in open fractures: a preliminary report.
abstract: The occurrence of infection following open fractures varies with the severity of the fracture and associated soft tissue damage. In order to study the effect of antibiotics given prophylactically, teicoplanin has been used in a prospective study. On admission, fractures were graded according to the severity of the tissue damage: Type I--soft tissue injury less than 1 cm Type II--soft tissue injury more than 1 cm. Type III fractures characterized by extensive soft tissue and bone damage were not included in the study. Type I patients were given a single dose of teicoplanin, 400 mg i.v.; Type II patients were given a single dose of teicoplanin, 400 mg i.v., followed by two further intravenous injections at 12 and 24 hours. Patients were assessed for the presence of wound and bone infections and follow up was for 1 year. Preliminary results, predominantly from Type II fractures involving long bones, show that teicoplanin is effective in lowering the incidence of infection following open fractures.
authors.affiliation: Department of Orthopaedic Surgery, University of Edinburgh, Scotland, UK.
authors.forename: S P
authors.initials: SP
authors.lastname: Hughes
authors.forename: E
authors.initials: E
authors.lastname: Strachan
authors.forename: R
authors.initials: R
authors.lastname: Miles
authors.forename: A H
authors.initials: AH
authors.lastname: Williams
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005597:Fractures, Open / Q000150:complications*; D006020:Glycopeptides / Q000008:administration & dosage / Q000627:therapeutic use; D016905:Gram-Negative Bacterial Infections / Q000517:prevention & control; D006801:Humans; D008297:Male; D008875:Middle Aged; D010000:Osteitis / Q000517:prevention & control; D011446:Prospective Studies; D017334:Teicoplanin; D014946:Wound Infection / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D017334:Teicoplanin