title: Estimation of extracellular space and blood volume using bioelectrical impedance measurements.
abstract: The bromide-82 dilution space (extracellular space, ECS) and blood volume (BV) were measured in 21 patients with esophageal and gastric cancer and in 27 patients 18-96 months after total gastrectomy. Resistance (R) and reactance (Xc) from bioelectrical impedance measurements were used to obtain multiple regression equations for ECS and BV. The variables weight, gender, and height 2/Xc were independent predictors of ECS (r = 0.767; P less than 0.0001). Height 2/R and gender were predictors of blood volume (r = 0.856; P less than 0.0001). The mean difference between the Br space and the ECS predicted from impedance measurements was 0 +/- 1.54 (mean +/- SD). The limits of agreement (+/- 2 SD) were therefore +/- 3.08 l or 19.6% of the mean Br space of 15.7 l. The limits of agreement for BV were +/- 789 ml or +/- 19.7% of the average BV of 4008 ml. It is concluded that bioelectrical impedance plethysmography using a single frequency can be used for the estimation of ECS and BV. The wide limits of agreement, however, may limit its used in clinical practice.
authors.affiliation: Klinik für Abdominal- und Transplantationschirurgie, Medizinische Hochschule Hannover.
authors.forename: J
authors.initials: J
authors.lastname: Miholic
authors.forename: L
authors.initials: L
authors.lastname: Reilmann
authors.forename: H J
authors.initials: HJ
authors.lastname: Meyer
authors.forename: H
authors.initials: H
authors.lastname: Körber
authors.forename: A
authors.initials: A
authors.lastname: Dieckelmann
authors.forename: R
authors.initials: R
authors.lastname: Pichlmayr
mesh_terms: D000328:Adult; D000368:Aged; D000886:Anthropometry; D001811:Blood Volume Determination / Q000379:methods*; D001823:Body Composition; D015992:Body Mass Index; D001834:Body Water; D001967:Bromine Radioisotopes; D004938:Esophageal Neoplasms / Q000473:pathology; D005069:Evaluation Studies as Topic; D005110:Extracellular Space; D005260:Female; D005743:Gastrectomy; D006801:Humans; D007201:Indicator Dilution Techniques; D008297:Male; D008875:Middle Aged; D010992:Plethysmography, Impedance; D011184:Postoperative Period; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery
chemical_list: D001967:Bromine Radioisotopes