p33, an endogenous target protein for arginine-specific ADP-ribosyltransferase in chicken polymorphonuclear leukocytes, is highly homologous to mim-1 protein (myb-induced myeloid protein-1).
We have determined the partial amino acid sequence of p33, an endogenous substrate protein for arginine-specific ADP-ribosyltransferase in chicken polymorphonuclear leukocytes (heterophils), and found that the sequence was completely identical with the regions of amino acid sequences deduced from mim-1 (named for myb-induced myeloid protein-1, which is expressed in chicken promyelocytes) cDNA [(1989) Cell, 59, 1115-1125], except for one amino acid difference (Tyr297-->Ile). These results together with data on cellular and subcellular distributions of p33 in heterophils suggest that mim-1 may encode the precursor protein of p33.
Yamada
K
K
Department of Biochemistry, Shimane Medical University, Izumo, Japan.
Tsuchiya
M
M
Mishima
K
K
Shimoyama
M
M
D036002:ADP Ribose Transferases / Q000378:metabolism*; D000123:Acetyltransferases; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002645:Chickens; D002851:Chromatography, High Pressure Liquid; D008969:Molecular Sequence Data; D009504:Neutrophils / Q000378:metabolism*; D010446:Peptide Fragments / Q000302:isolation & purification; D010449:Peptide Mapping; D011506:Proteins / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D013379:Substrate Specificity
D010446:Peptide Fragments; D011506:Proteins; D000123:Acetyltransferases; C077509:mim-1 protein, Gallus gallus; D036002:ADP Ribose Transferases