Increase in rat pup ultrasonic isolation calls induced by lindane.
The neurotoxic agent lindane was tested for its ability to alter the rate of ultrasonic isolation calls of suckling rats. Doses that did not produce any sign of convulsant activity significantly increased the number of calls and the cumulative time of calling in male pups. At days 10-13 of age after a single dose of 20 mg/kg lindane, animals showed more than twice the control call values. After daily dosing with 10 mg/kg during the first week of age call increases also appeared. It is suggested that lindane has an anxiogenic effect mediated through its action on the benzodiazepine-GABAA receptor-chloride channel complex.
Rivera
S
S
Department of Pharmacology and Toxicology, CSIC, Barcelona, Spain.
Sanfeliu
C
C
García
M
M
Comellas
F
F
Rodríguez-Farré
E
E
D000818:Animals; D001007:Anxiety / Q000139:chemically induced*; D004334:Drug Administration Schedule; D005260:Female; D001556:Hexachlorocyclohexane / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012934:Social Isolation; D014465:Ultrasonics; D014828:Vocalization, Animal / Q000187:drug effects*
D001556:Hexachlorocyclohexane