[The role of lactate acidosis and enzyme hyperactivity in evaluating hypoxic organ disorders in patients following cardiopulmonary byøass].
One hundred and fifty patients after cardiopulmonary bypass surgery have been examined. It has been shown that overall enzyme activity should be taken into consideration when determining the genesis of postoperative hyperenzymemia and diagnosing the topical (organic) damage. High lactate level (6-8 mmol/l) reflects profound circulatory hypoxia and shows a great likelihood of secondary damage of parenchymatous organs in patients after cardiopulmonary bypass surgery. Marked lactatacidosis combined with a 5-10-fold increase in enzyme activity in the early postoperative period is an unfavourable prognostic sign. Prolonged antagosan (trasilol) administration during cardiopulmonary bypass surgery may be one of the techniques preventing and correcting hypoxic organ damage.
Dement'eva
I I
II
Abbakumov
V V
VV
Mikhaĭlov
Iu E
IuE
Leonova
S F
SF
Luchina
O O
OO
D000140:Acidosis, Lactic / Q000503:physiopathology*; D000293:Adolescent; D000328:Adult; D007611:Aprotinin / Q000627:therapeutic use; D002315:Cardiopulmonary Bypass; D002648:Child; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology* / Q000517:prevention & control; D008875:Middle Aged; D011183:Postoperative Complications / Q000201:enzymology / Q000378:metabolism*
D007611:Aprotinin