title: Effect of dietary sunflower seed oil on the severity of reperfusion-induced arrhythmias in anesthetized rats.
abstract: Myocardial ischemia followed by reperfusion was produced in artificially respirated, open-chest rats. Coronary artery ligation for 6 min rarely evoked arrhythmias; however, reperfusion after this period rapidly produced severe dysrhythmias in all control animals. Reperfusion after 12 min of ischemia produced less frequent dysrhythmias than after coronary occlusion for 6 min. Feeding of a linoleic acid-rich diet, applying 12% sunflower seed oil in rat food pellet for 4 weeks, decreased the incidence of reperfusion-induced ventricular fibrillation both after 6 min (2/15 vs. 7/11) and 12 min (0/11 vs. 2/8) of myocardial ischemia and the incidence of other arrhythmias was also decreased. The number of animals developing no arrhythmias during reperfusion was increased (8/15 after 6 min of ischemia, 4/11 after 12 min of ischemia vs. 0/11 and 0/8 in controls, respectively). Our results indicate that increased dietary consumption of linoleic acid decreased the occurrence of life-threatening arrhythmias both during the acute phase of myocardial ischemia and during reperfusion in anesthetized rats.
authors.affiliation: Department of Pharmacology, A. Szent-Györgyi University Medical School, Szeged, Hungary.
authors.forename: I
authors.initials: I
authors.lastname: Leprán
authors.forename: L
authors.initials: L
authors.lastname: Szekeres
mesh_terms: D000758:Anesthesia; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000178:diet therapy / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology; D003327:Coronary Disease / Q000178:diet therapy / Q000503:physiopathology; D003331:Coronary Vessels / Q000502:physiology; D004042:Dietary Fats, Unsaturated / Q000627:therapeutic use*; D006339:Heart Rate / Q000502:physiology; D008041:Linoleic Acids / Q000494:pharmacology; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000178:diet therapy / Q000503:physiopathology*; D010938:Plant Oils / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D000074242:Sunflower Oil
chemical_list: D004042:Dietary Fats, Unsaturated; D008041:Linoleic Acids; D010938:Plant Oils; D000074242:Sunflower Oil