title: Partial correction of impaired creatine kinase activity in diabetic rat heart by physical training.
abstract: The effect of physical training on total creatine kinase (CK), CK-MM, and CK-MB isoenzyme activity was studied in hearts of diabetic and control rats. Diabetes was induced with streptozotocin (50 mg/kg), and only rats with blood glucose levels between 14 and 22 mmol/L 1 week later were kept in the protocol. Exercise training was performed on a treadmill in a progressive 10-week program. Physical training did not induce any significant changes in plasma glucose or insulin levels in diabetic rats. Total CK, CK-MM, and CK-MB activity was decreased in diabetic rat heart by 27%, 22%, and 56%, respectively. Physical training did not induce any important changes in CK activity in heart of nondiabetic rats. However, in diabetic rat heart, training increased total CK activity by 13%, CK-MM activity by 12%, and CK-MB activity by 31%. We conclude that the decrease in cardiac CK activity observed in chronic experimental diabetes mellitus can be partly alleviated by a program of physical training. This may be one of the mechanisms whereby physical conditioning improves cardiac function in experimental diabetes.
authors.affiliation: Diabetes Research Unit, CHUL Research Center, Laval University Medical Center, Ste-Foy, Quebec, Canada.
authors.forename: N
authors.initials: N
authors.lastname: Mokhtar
authors.forename: S
authors.initials: S
authors.lastname: Rousseau-Migneron
authors.forename: G
authors.initials: G
authors.lastname: Tancrède
authors.forename: A
authors.initials: A
authors.lastname: Nadeau
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003402:Creatine Kinase / Q000378:metabolism / Q000502:physiology*; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology* / Q000503:physiopathology; D006321:Heart / Q000502:physiology; D007328:Insulin / Q000097:blood; D007527:Isoenzymes / Q000378:metabolism / Q000502:physiology; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D010758:Phosphorus / Q000032:analysis; D010805:Physical Conditioning, Animal; D051381:Rats; D013311:Streptozocin
chemical_list: D001786:Blood Glucose; D007328:Insulin; D007527:Isoenzymes; D010758:Phosphorus; D013311:Streptozocin; D003402:Creatine Kinase