[The effect of carnitine on the early phase of liver regeneration after partial hepatectomy in rats with experimental diabetes].
The effect of intraperitoneally administered carnitine (10 or 100 mg/kg) on the early stage of liver regeneration after two-third hepatectomy was studied in rats with experimentally induced alloxan diabetes (60 mg/kg IV). The level of regeneration was assessed mainly on the basis of DNA synthesis in the liver. Untreated diabetic rats exhibited significantly lower values of DNA synthesis determined 24 hours after hepatectomy. Administration of carnitine resulted in a significant increase in DNA synthesis over the given time interval. The stimulatory effect of carnitine in diabetic rats was confirmed also by the recorded values of serum lipids, particularly by the decreased concentration of triacylglycerols and the increased concentration of HDL-cholesterol, as determined in carnitine treated diabetic rats 24 hours following partial hepatectomy. (Tab. 2, Fig. 3, Ref. 34.)
Cervinková
Z
Z
Katedra fyziologie a patologické fyziologie a II. interní klinika lékarské fakulty Univerzity Karlovy, CSFR.
Kalinová
M
M
Simek
J
J
D000818:Animals; D002331:Carnitine / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism / Q000503:physiopathology*; D006498:Hepatectomy; D008099:Liver / Q000378:metabolism; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D051381:Rats
D004247:DNA; D002331:Carnitine