Studies about the oral bioavailability of mitonafide and 2HCl amonafide, two new cytotoxic molecules.
A study was done on the factors which could modify the oral bioavailability of two new cytotoxic molecules (mitonafide and 2HCl amonafide) when administered in solid form. From the values of the ionization constants, we can assume that the absorption of these drugs is produced in the first segments of the small intestine. In the course of both molecules through the digestive tract to the site of absorption, we presume that their chemical stability will not be significantly compromised by the influence of pH of the GI tract. The high aqueous solubility of 2HCl amonafide and the rapid dissolution rate of mitonafide at low pH values lead to assume that the previous dissolution of the drugs will not be an essential factor in the absorption of the oral form.
Torres Suárez
A I
AI
Departamento de Farmacia y Technología Farmacéutica, Facultad de Farmacia, Universidad Complutense de Madrid, España.
Camacho Sánchez
M A
MA
D000225:Adenine; D000970:Antineoplastic Agents / Q000737:chemistry / Q000493:pharmacokinetics*; D001682:Biological Availability; D006863:Hydrogen-Ion Concentration; D007094:Imides; D007364:Intercalating Agents / Q000493:pharmacokinetics*; D007546:Isoquinolines / Q000737:chemistry / Q000493:pharmacokinetics*; D053644:Naphthalimides; D063065:Organophosphonates; D012995:Solubility
D000970:Antineoplastic Agents; D007094:Imides; D007364:Intercalating Agents; D007546:Isoquinolines; D053644:Naphthalimides; D063065:Organophosphonates; C019215:mitonafide; C037020:amonafide; D000225:Adenine