title: Differences between KT/V measured during dialysis and KT/V predicted from manufacturer clearance data.
abstract: We retrospectively analyzed data from 3,863 dialysis treatments in 329 end-stage renal disease patients over a period of 33 months to evaluate the accuracy of in vitro KT/V estimated by manufacturer's urea clearance data in relation to in vivo measured KT/V. In 1,087 urea clearances measured, mean actual clearance was 87% of predicted. At all blood flows, actual clearances were significantly lower than predicted (8-16% lower than predicted). In 2,807 KT/V measurements, predicted KT/V was 1.238 +/- 0.005 whereas the mean of actual measured KT/V was 16% lower or 1.024 +/- 0.005 (P less than 0.0001). At different blood flows and with different dialyzers, predicted KT/V overestimated actual values. With increasing numbers of reuse, actual/predicted clearance ratios and actual/predicted KT/V ratios progressively dropped. Prescribing dialysis treatments using manufacturer's in vitro generated clearance data can lead to marked underdialysis of patients.
authors.affiliation: Department of Medicine, University of Missouri School of Medicine, Dialysis Clinic, Inc., Columbia.
authors.forename: L K
authors.initials: LK
authors.lastname: Saha
authors.forename: J C
authors.initials: JC
authors.lastname: Van Stone
mesh_terms: D000328:Adult; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D006435:Renal Dialysis; D012189:Retrospective Studies; D014508:Urea / Q000097:blood*
chemical_list: D014508:Urea