Comparison of hematopoietic and immune recovery after autologous bone marrow or blood stem cell transplants.
We studied hematopoietic and immune recovery in 40 subjects receiving autologous bone marrow (ABMT) or blood stem cell transplants (ABSCT). Supportive care, transplant-related morbidity, duration of hospitalization and cost were also considered. ABSCT was associated with more rapid recovery of all hematopoietic lineages than was ABMT. However, kinetics of immune recovery were similar between the groups. In the ABSCT group, there was a correlation between numbers of blood progenitor cells infused and the rate of hematopoietic recovery. The accelerated hematopoietic recovery following ABSCT correlated with less morbidity, fewer transfusions, briefer hospitalization and lower cost than ABMT.
Henon
P R
PR
Service d'Hématologie, Hopital du Hasenrain, Mulhouse, France.
Liang
H
H
Beck-Wirth
G
G
Eisenmann
J C
JC
Lepers
M
M
Wunder
E
E
Kandel
G
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D001773:Blood Cells / Q000276:immunology / Q000473:pathology / Q000637:transplantation*; D001804:Blood Transfusion, Autologous; D016026:Bone Marrow Transplantation / Q000276:immunology / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006410:Hematopoiesis; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000276:immunology / Q000473:pathology; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000276:immunology / Q000473:pathology / Q000601:surgery; D005719:gamma-Globulins / Q000378:metabolism
D007136:Immunoglobulins; D005719:gamma-Globulins