Feto-maternal interaction of IGF-I and its binding proteins in fetal growth.
Elevated levels of maternal IGF-I and IGF-binding proteins IGFBP-1 are regulated by placental hormones rather than pituitary control during pregnancy. Maternal IGF-I promotes fetal growth by stimulating nutrient transfer to fetus through placenta and IGFBP-1 suppresses fetal growth by inhibiting IGF-I binding to receptors in placenta. Since IGF-I and IGFBP-1 are produced in placenta and decidua, respectively, fetal growth is regulated by these substances in the locally formed paracrine system.
Iwashita
M
M
Maternal and Perinatal Center, Tokyo Women's Medical College, Japan.
Kobayashi
M
M
Matsuo
A
A
Nakayama
S
S
Mimuro
T
T
Takeda
Y
Y
Sakamoto
S
S
D002352:Carrier Proteins / Q000502:physiology*; D005314:Embryonic and Fetal Development / Q000502:physiology*; D005260:Female; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D013002:Somatomedins / Q000502:physiology*
D002352:Carrier Proteins; D018969:Insulin-Like Growth Factor Binding Proteins; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I