title: Potential antitumor agents XIX [1]. Synthesis and antitumor activity of tricyclic compounds related to lotifazole.
abstract: The synthesis of phenothiazine and anthraquinone derivatives, bearing at least one fragment present in lotifazole, is reported. Some of the new compounds showed antitumor activity in vitro (P388 leukemia cells) and in vivo (Ehrlich ascites tumor cells in mice).
authors.affiliation: Dipartimento di Scienze Farmaceutiche, University of Bologna.
authors.forename: A
authors.initials: A
authors.lastname: Andreani
authors.forename: M
authors.initials: M
authors.lastname: Rambaldi
authors.forename: A
authors.initials: A
authors.lastname: Locatelli
authors.forename: A
authors.initials: A
authors.lastname: Fraccari
authors.forename: R
authors.initials: R
authors.lastname: Bossa
authors.forename: I
authors.initials: I
authors.lastname: Galatulas
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002219:Carbamates / Q000138:chemical synthesis* / Q000494:pharmacology; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D005260:Female; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D002219:Carbamates; D011083:Polycyclic Compounds; C040605:lotifazole