title: CD5+ B cells from bovine leukemia virus infected cows are activated cycling cells responsive to interleukin 2.
abstract: Most of the B cells from bovine leukemia virus (BLV) infected cows in persistent lymphocytosis (PL) were known to express the CD5 T-cell marker but it was not known whether this peculiar membrane phenotype relates to an activation state. It was demonstrated that these B cells were also flagged by two other membrane markers normally borne by cells belonging to the myeloid lineage (namely CD11b and CD11c). Moreover, cell cycle analysis illustrated that a significant percentage of these B cells (greater than 15%) left their resting (G0/G1) status and progressed through the cell cycle. In addition, T-cell-depleted peripheral blood mononuclear cells from animals in PL were shown to proliferate in response to a IL-2-containing supernatant (MLA 144). These results indicate that the CD5+ B cells from BLV-infected cows in PL are activated cells.
authors.affiliation: Department of Immunology, University of Namur, Belgium.
authors.forename: J P
authors.initials: JP
authors.lastname: Matheise
authors.forename: M
authors.initials: M
authors.lastname: Delcommenne
authors.forename: A
authors.initials: A
authors.lastname: Mager
authors.forename: C H
authors.initials: CH
authors.lastname: Didembourg
authors.forename: J J
authors.initials: JJ
authors.lastname: Letesson
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000378:metabolism*; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology; D018956:CD5 Antigens; D002417:Cattle; D002453:Cell Cycle; D016130:Immunophenotyping; D007376:Interleukin-2 / Q000494:pharmacology*; D001909:Leukemia Virus, Bovine; D007942:Leukemia, Experimental / Q000150:complications / Q000276:immunology* / Q000473:pathology; D008213:Lymphocyte Activation; D008218:Lymphocytosis / Q000209:etiology / Q000276:immunology / Q000473:pathology
chemical_list: D015703:Antigens, CD; D018956:CD5 Antigens; D007376:Interleukin-2