Metabolic differences and similarities of selenium in blood and brain of the rat following the administration of different selenium compounds.
A common intermediate, i.e., selenite, was found in the serum of the rat; the maximum levels occurred 3 h after administration independent of chemical forms. This indicates that both the reduction of selenate to selenite, and oxidation of seleno-dl-methionine to selenite existed in the metabolic pathways of the rat. We found that water-soluble selenium compounds led to a similar maximum content in blood and serum, but seleno-dl-methionine had a higher affinity for the brain and, by gel filtration chromatography, for the higher mol-wt (25-100 K Da) fractions of serum protein, when compared with inorganic forms.
Wang
Z J
ZJ
Research Centre For Eco-Environmental Sciences, Academia Sinica, Beijing, PR China.
Zhou
J
J
Peng
A
A
D000818:Animals; D001921:Brain / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D064586:Selenic Acid; D020887:Selenious Acid; D012643:Selenium / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics; D018036:Selenium Compounds; D012645:Selenomethionine / Q000378:metabolism / Q000493:pharmacokinetics
D018036:Selenium Compounds; D012645:Selenomethionine; D020887:Selenious Acid; D012643:Selenium; D064586:Selenic Acid