Effect of methyl methacrylate on isolated atria and interaction with isoproterenol, atropine and calcium chloride.
1. Spontaneous rate and contractile force of isolated rat and rabbit atria suspended in a tissue bath were recorded before and after drugs. Methyl methacrylate monomer (MMA) alone both decreased force and increased rate dose-dependently. 2. Concentrations of calcium chloride or isoproterenol that alone increased both rate and force of rat atrial contraction were fully and only partially able, respectively, to restore force to normal after MMA. 3. Atropine prevented changes in rat atrial function from low-effective doses of MMA, but not higher ones; it also failed to prevent the reduction of contractile force by a calcium channel blocker, verapamil. 4. There are similarities but also differences between actions of MMA and verapamil on rat atria.
Baran
K P
KP
Department of Pharmacology, School of Pharmacy, University of Mississippi, University 38677.
Davis
W M
WM
Waters
I W
IW
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D002122:Calcium Chloride / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D020366:Methylmethacrylate; D008768:Methylmethacrylates / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects; D011817:Rabbits; D051381:Rats
D008768:Methylmethacrylates; D020366:Methylmethacrylate; D001285:Atropine; D007545:Isoproterenol; D002122:Calcium Chloride