The Wnt gene family in tumorigenesis and in normal development.
Various members of the Wnt gene family have been identified as activated oncogenes in mouse mammary tumors. We show that some tumors are oligoclonal for activation of a Wnt gene, and clonal variation when those tumors are transplanted to become hormone-independent. The normal function of many Wnt genes is to control pattern formation in early embryos, as shown by expression profiles and by mutant analysis.
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Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University, CA 94305.
D000818:Animals; D004330:Drosophila / Q000196:embryology / Q000235:genetics; D005314:Embryonic and Fetal Development / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D008325:Mammary Neoplasms, Experimental / Q000235:genetics; D051379:Mice; D005810:Multigene Family; D009857:Oncogenes; D011518:Proto-Oncogene Proteins / Q000235:genetics* / Q000502:physiology; D051153:Wnt Proteins; D029961:Zebrafish Proteins
D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; D029961:Zebrafish Proteins