Effect of dexamethasone on the nerve growth factor-induced increase in the NILE glycoprotein in PC12 cells.
The long-known and well-documented increase in the NILE glycoprotein produced by nerve growth factor in PC12 cells is prevented by simultaneous treatment with dexamethasone. The absence of this surface marker on the fully differentiated cells has been demonstrated by both glucosamine incorporation and immunohistofluorescence.
Tocco
M D
MD
Section of Growth Factors, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892.
Fujita
K
K
Guroff
G
G
D000818:Animals; D015816:Cell Adhesion Molecules, Neuronal / Q000096:biosynthesis; D002454:Cell Differentiation / Q000187:drug effects; D003907:Dexamethasone / Q000494:pharmacology*; D016326:Extracellular Matrix Proteins / Q000096:biosynthesis; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D005944:Glucosamine / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000096:biosynthesis*; D009363:Neoplasm Proteins / Q000096:biosynthesis; D009414:Nerve Growth Factors / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D039842:Neural Cell Adhesion Molecule L1; D016716:PC12 Cells / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism; D017475:Receptors, Nerve Growth Factor; D019063:Tenascin
D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D039842:Neural Cell Adhesion Molecule L1; D011956:Receptors, Cell Surface; D017475:Receptors, Nerve Growth Factor; D019063:Tenascin; D003907:Dexamethasone; D005944:Glucosamine