[Immunogenetic studies of familial occurrence of progressive systemic scleroderma and circumscribed scleroderma].
Two different forms of scleroderma in one family are described: the mother suffers from systemic sclerosis and her daughter from linear morphoea. The observed HLA antigens indicate that systemic sclerosis and morphoea have various features in common. The immunogenetic data can be used to calculate the aetiological and preventive fractions, which together with environmental hazards and other risk factors describe the HLA-associated potential for provocation of scleroderma.
Holzmann
H
H
Abteilung I, Johann-Wolfgang-Goethe-Universität Frankfurt/Main.
Schlieter
A
A
Altmeyer
P
P
Kühnl
P
P
D000293:Adolescent; D000328:Adult; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012307:Risk Factors; D012594:Scleroderma, Localized / Q000235:genetics* / Q000276:immunology; D012595:Scleroderma, Systemic / Q000235:genetics* / Q000276:immunology
D006680:HLA Antigens