title: Cytotoxicity of tin on human peripheral lymphocytes in vitro.
abstract: The comparative effects of inorganic and organic tin compounds on chromosomes were assessed in human peripheral blood lymphocytes of healthy donors 20-40 years of age. The endpoints observed were chromosomal abnormalities, sister-chromatid exchanges (SCEs) and cell cycle kinetics. The maximum concentrations which reduced the replicative index by about 50%, of stannic chloride and trimethyltin chloride were 40 micrograms and 2 micrograms per culture respectively. The tested doses were 20 micrograms and 10 micrograms of stannic chloride and 1 microgram and 0.5 microgram of trimethyltin chloride. Both doses of stannic chloride induced a much higher frequency of chromosomal abnormalities (P less than 0.05-P less than 0.001) and a greater reduction of cell cycle kinetics than the corresponding relative doses of trimethyltin chloride. The frequencies of SCEs/cell induced by the latter were, however, slightly higher than those induced by the former.
authors.affiliation: Department of Botany, University of Calcutta, India.
authors.forename: B B
authors.initials: BB
authors.lastname: Ganguly
authors.forename: G
authors.initials: G
authors.lastname: Talukdar
authors.forename: A
authors.initials: A
authors.lastname: Sharma
mesh_terms: D002453:Cell Cycle / Q000187:drug effects; D002869:Chromosome Aberrations; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects*; D016296:Mutagenesis; D009942:Organometallic Compounds / Q000633:toxicity; D012854:Sister Chromatid Exchange / Q000187:drug effects; D014001:Tin / Q000633:toxicity*
chemical_list: D009942:Organometallic Compounds; D014001:Tin