[Swiss Register for unrelated bone marrow donors: preliminary results].
Bone marrow transplantation from the unrelated volunteer donor is today a realistic possibility for patients lacking an HLA-identical family donor. In 1988, the Swiss Unrelated Bone Marrow Donor Registry was founded to coordinate such bone marrow transplants and create the Swiss volunteer donor registry. Thus for a search has been initiated for 71 patients and 16 transplants have been performed. Donor and recipient were HLA-A-, -B- identical by serology and HLA-Dr-identical by DNA-oligotyping. 10 of the 16 patients are alive without signs of basic disease 2 weeks to 2 years and 4 months after the transplant. These results illustrate that unrelated donor transplantation, using careful selection criteria, is a realistic new therapeutic modality.
Gratwohl
A
A
Departement Innere Medizin, Kantonsspital Basel.
Helg
C
C
Chapuis
B
B
Gmür
J
J
Jeannet
M
M
Kern
M
M
Tichelli
A
A
Speck
B
B
Signer
E
E
Wyss
M
M
D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D005260:Female; D006680:HLA Antigens; D006650:Histocompatibility Testing / Q000379:methods; D006801:Humans; D007223:Infant; D007256:Information Systems; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D012042:Registries; D013557:Switzerland; D014019:Tissue Donors
D006680:HLA Antigens