title: Fluoride concentrations in plaque, whole saliva, and ductal saliva after application of home-use topical fluorides [published eerratum appears in J Dent Res 1993 Jan;72(1):87].
abstract: It is now well-accepted that the primary anti-caries activity of fluoride (F) is via topical action. The retention of F in the mouth after topical fluoride treatment is considered to be an important factor in the clinical efficacy of F. The purpose of this study was to evaluate F levels in ductal saliva, whole saliva, and pooled plaque after treatment with topical F agents intended for home use. Ten consenting adults, mean (SD) age 31.0 (8.2) years, participated in all aspects of the study. Two days before each test, subjects received a professional tooth cleaning and subsequently abstained from all oral hygiene procedures to permit plaque to accumulate, and from the use of F-containing dental products. Treatments consisted of a placebo dentifrice (PD), fluoride dentifrice (FD; 0.24% NaF), fluoride rinse (FR; 0.05% NaF), and fluoride gel (FG; 1.1% NaF). Unstimulated whole saliva and pooled plaque were sampled at multiple points over a 24-hour period. In a separate experimental series, stimulated parotid saliva was sampled over a two-hour period after treatment. Fluoride levels generally followed the same pattern in whole saliva and pooled plaque samples, with FG > FR > FD > PD. Night-time F application resulted in prolonged F retention in whole saliva but not in plaque. Fluoride levels in parotid saliva were only slightly higher after F treatment and returned to baseline levels within two h. The results of this study indicate that the method of F delivery, the F concentration of the agent, and the time of application (daytime vs. night-time) are important factors influencing F levels in the mouth.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Oral Sciences, Eastman Dental Center, Rochester, New York 14620.
authors.forename: D T
authors.initials: DT
authors.lastname: Zero
authors.forename: R F
authors.initials: RF
authors.lastname: Raubertas
authors.forename: J
authors.initials: J
authors.lastname: Fu
authors.forename: A M
authors.initials: AM
authors.lastname: Pedersen
authors.forename: A L
authors.initials: AL
authors.lastname: Hayes
authors.forename: J D
authors.initials: JD
authors.lastname: Featherstone
mesh_terms: D000293:Adolescent; D000328:Adult; D002940:Circadian Rhythm; D003773:Dental Plaque / Q000737:chemistry*; D003802:Dentifrices; D005260:Female; D005460:Fluorides, Topical / Q000032:analysis / Q000493:pharmacokinetics*; D005782:Gels; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes; D009910:Oral Hygiene / Q000379:methods; D012463:Saliva / Q000737:chemistry* / Q000378:metabolism; D012636:Secretory Rate
chemical_list: D003802:Dentifrices; D005460:Fluorides, Topical; D005782:Gels; D009067:Mouthwashes