Condensation products of 2-amino-3-cyano-4,6-disubstituted pyridine with carbon disulfide, thiourea, urea & formamide and their antibacterial activity.
Some new 5,7-disubstituted pyrido[2,3-d]pyrimidine derivatives have been synthesized by the condensation of 2-amino-3-cyano-4,6-disubstituted pyridine with carbon disulfide, thiourea, urea and formamide. The structure of these products are supported by their IR and 1H-NMR spectra as well as by elemental analysis. The compounds have been tested for their antibacterial activity against E. coli and S. aureus.
Gupta
A
A
Department of Chemistry, Rajasthan University, Jaipur, India.
Shaihla
Mital
R L
RL
Prakash
L
L
D000631:Aminopyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002246:Carbon Disulfide; D004926:Escherichia coli / Q000187:drug effects; D005559:Formamides; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects; D013890:Thiourea; D014508:Urea
D000631:Aminopyridines; D000900:Anti-Bacterial Agents; D005559:Formamides; D014508:Urea; D013890:Thiourea; D002246:Carbon Disulfide