Heat-shock proteins: immunity and autoimmunity.
Antigens from a wide variety of pathogens have been identified as members of conserved heat-shock protein families, sharing upwards of 50% amino acid identity with corresponding host-cell proteins. Analysis of the responses to these conserved antigens may provide insights into regulation of the immune system during infection and autoimmunity.
Young
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MRC Tuberculosis and Related Infections Unit, RPMS, Hammersmith Hospital, London, UK.
D000818:Animals; D001169:Arthritis, Experimental / Q000276:immunology; D016918:Arthritis, Reactive / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology; D015551:Autoimmunity; D001426:Bacterial Proteins / Q000276:immunology; D004195:Disease Models, Animal; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D007109:Immunity; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology
D001426:Bacterial Proteins; D006360:Heat-Shock Proteins; D016692:Receptors, Antigen, T-Cell, gamma-delta