Novel adjuvant action of lipopolysaccharides that possess mannose homopolysaccharides as O-specific polysaccharides on immune responses to nonimmunogenic autoantigens in mice.
The adjuvant action of various lipopolysaccharides on immune responses to syngeneic tissue extract in mice was examined. Only lipopolysaccharides possessing the linear mannose homopolysaccharides as O-specific polysaccharides exhibited definite adjuvant action on immune responses to the autoantigens. The intensity of this adjuvant activity of lipopolysaccharide from Klebsiella O3 seemed to be the strongest.
Yokochi
T
T
Department of Microbiology, Aichi Medical University School of Medicine, Japan.
Fukada
M
M
Kawai
M
M
Zhang
Y H
YH
Jiang
G Z
GZ
Takahashi
K
K
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D002240:Carbohydrate Sequence; D004926:Escherichia coli / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007709:Klebsiella / Q000276:immunology; D008070:Lipopolysaccharides / Q000737:chemistry / Q000276:immunology*; D008297:Male; D008362:Mannosides / Q000276:immunology; D051379:Mice; D008969:Molecular Sequence Data; D019081:O Antigens; D009920:Orchitis / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D012475:Salmonella / Q000276:immunology; D013737:Testis / Q000276:immunology; D013961:Thyroid Gland / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000276:immunology*
D000942:Antigens, Bacterial; D001324:Autoantigens; D008070:Lipopolysaccharides; D008362:Mannosides; D019081:O Antigens; D011135:Polysaccharides, Bacterial