Studies on the intravenous pharmacokinetics in rabbit and in vitro protein binding of two new salts of erythromycin: erythromycin maltobionate and erythromycin fumarate.
Pharmacokinetics in rabbits following intravenous administration and in vitro protein binding were studied for two new salts of erythromycin (erythromycin maltobionate and erythromycin fumarate). Serum erythromycin levels following intravenous injection were described by two compartment model kinetics, and values for the distribution volume of the central compartment, the peripheral compartment and overall distribution volume were calculated. The elimination half-lives of erythromycins in serum were 83 min, 168 min, and 103 min for erythromycin maltobionate, erythromycin fumarate, and erythromycin lactobionate (reference standard), respectively. The erythromycin salts were highly (c. 90 per cent) protein bound, but the binding was found to be reversible. Differences in the pharmacokinetic parameters after administration of equivalent doses of the salts, indicate possible variation in efficacies of different salts.
Basu
S K
SK
Department of Pharmacy, Jadavpur University, Calcutta, India.
Manna
P K
PK
Goswami
B B
BB
D000818:Animals; D004917:Erythromycin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D011485:Protein Binding; D011817:Rabbits
D004917:Erythromycin