Clonal aberrations of chromosomes X, Y, 7 and 10 in normal kidney tissue of patients with renal cell tumors.
By means of G-banding techniques, chromosome aberrations were studied in short-term cultures of normal renal parenchymal cells from 45 patients with renal cell carcinoma. Clonal chromosomal aberrations were detected in 29 patients; loss of the Y chromosome as well as trisomy X, 5, 7, 9, 10, 12, and 18 was found. Chromosomes 7 and 10 were involved preferentially. Results of fluorescence in situ hybridization with chromosome 7- and 10-specific DNA probes on non-cultured normal kidney cells suggested that the aberrations developed in vivo.
Emanuel
A
A
Laboratory of Cytogenetics, Institute of Pathology, Albert-Ludwigs-University, Freiburg, Federal Republic of Germany.
Szucs
S
S
Weier
H U
HU
Kovacs
G
G
D002292:Carcinoma, Renal Cell / Q000473:pathology*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002879:Chromosomes, Human, Pair 10 / Q000648:ultrastructure; D002897:Chromosomes, Human, Pair 7 / Q000648:ultrastructure; D002999:Clone Cells / Q000473:pathology*; D015342:DNA Probes; D005260:Female; D005456:Fluorescent Dyes; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D009030:Mosaicism; D009693:Nucleic Acid Hybridization; D014960:X Chromosome / Q000648:ultrastructure; D014998:Y Chromosome / Q000648:ultrastructure
D015342:DNA Probes; D005456:Fluorescent Dyes