title: Induction of external abnormalities in offspring of male mice irradiated with 252Cf neutron.
abstract: To assess the genetic effects of fission neutron, the induction of external malformations was studied in F1 fetuses after F0 male mice were irradiated. Male mice of the ICR:MCH strain were irradiated with 252Cf neutron at doses of 0.238, 0.475, 0.95 and 1.9 Gy. They were mated with non-irradiated female mice at 71-120 days after the irradiation. Pregnant females were autopsied on day 18 of gestation and their fetuses were examined for deaths and external abnormalities. No increases of pre- and post-implantation losses were noted at any dose. External abnormalities were observed at rates of 1.40% in the 0.238 Gy, 2.23% in the 0.475 Gy, 3.36% in the 0.95 Gy and 3.26% in the 1.9 Gy groups; the rate in the control group was 1.65%. The dose-response curve was linear up to 0.95 Gy, and then flattened out; the induction rate of external abnormalities was 2.7 x 10(-4)/gamete/cGy based on the linear regression. These results indicated that fission neutron effectively induces external abnormalities in F1 fetuses after spermatogonial irradiation.
authors.affiliation: Department of Radiation Research, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kurishita
authors.forename: T
authors.initials: T
authors.lastname: Ono
authors.forename: S
authors.initials: S
authors.lastname: Okada
authors.forename: Y
authors.initials: Y
authors.lastname: Mori
authors.forename: S
authors.initials: S
authors.lastname: Sawada
mesh_terms: D000016:Abnormalities, Radiation-Induced / Q000209:etiology*; D000704:Analysis of Variance; D000818:Animals; D002142:Californium; D016009:Chi-Square Distribution; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D016296:Mutagenesis; D009502:Neutrons / Q000009:adverse effects*; D009680:Nuclear Fission; D011247:Pregnancy; D012044:Regression Analysis; D013093:Spermatogonia / Q000528:radiation effects*
chemical_list: D002142:Californium