The signal-induced phospholipid degradation cascade and protein kinase C activation.
Acting in synergy with diacylglycerol, unsaturated free fatty acids such as arachidonic, oleic, linoleic, linolenic and docosahexaenoic acids dramatically activate some members of the protein kinase C family at the basal level of Ca2+ concentration. It is plausible that phospholipase C and phospholipase A2, and possibly phospholipase D as well, are involved in the activation of protein kinase C. Presumably, this enzyme activation is integrated into the signal-induced membrane phospholipid degradation cascade, prolonging the activation of protein kinase C. The sustained activity of this enzyme appears to be of importance for long-term cellular responses such as development of neuronal plasticity and gene activation.
Asaoka
Y
Y
Biosignal Research Center, Kobe University, Japan.
Yoshida
K
K
Oka
M
M
Shinomura
T
T
Mishima
H
H
Matsushima
S
S
Nishizuka
Y
Y
D000818:Animals; D004075:Diglycerides / Q000494:pharmacology*; D004357:Drug Synergism; D004789:Enzyme Activation / Q000502:physiology; D005230:Fatty Acids, Nonesterified / Q000494:pharmacology*; D010743:Phospholipids / Q000378:metabolism*; D011493:Protein Kinase C / Q000187:drug effects / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D013569:Synapses / Q000187:drug effects
D004075:Diglycerides; D005230:Fatty Acids, Nonesterified; D010743:Phospholipids; D011493:Protein Kinase C