Emergence of optic pathway gliomas in children with neurofibromatosis type 1 after normal neuroimaging results.
We report the appearance of gliomas of the optic nerve or chiasm in four young children with neurofibromatosis type 1 whose previous neuroimaging studies showed no abnormalities; the age range of the children was 1 year 8 months to 5 years 9 months at the time the tumors were detected. Normal neuroimaging findings in an infant or young child with neurofibromatosis type 1 does not provide assurance that the optic nerves and chiasm will remain healthy.
Listernick
R
R
Department of Pediatrics, Northwestern University Medical School, Chicago, Illinois.
Charrow
J
J
Greenwald
M
M
D002675:Child, Preschool; D003390:Cranial Nerve Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000000981:diagnostic imaging; D009442:Neurilemmoma / Q000175:diagnosis* / Q000000981:diagnostic imaging; D009456:Neurofibromatosis 1; D009897:Optic Chiasm / Q000000981:diagnostic imaging / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed