Adenosine A1 receptor gene structure and regulation in normotensive and spontaneously hypertensive rats.
In spontaneously hypertensive rats (SHR), both the response to adenosine and the affinity of adenosine A1 receptors (A1R) are altered. We compared the coding sequences and the mRNA expression levels of A1R in SHR and normotensive Wistar rats (NWTR). Neither the nucleotide sequence nor the mRNA level of A1R are altered in SHR, so that gene mutations or an altered gene regulation of A1R cannot account for alterations in A1R function in SHR.
Ungerer
M
M
Laboratorium für molekulare Biologie, Universität München, Max-Planck-Institut für Biochemie, Martinsried, Germany.
Obermaier-Skrobranek
B
B
Lohse
M J
MJ
D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D005786:Gene Expression Regulation; D006973:Hypertension / Q000235:genetics* / Q000378:metabolism; D009154:Mutation; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000235:genetics*; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar; D011983:Receptors, Purinergic / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic
D012333:RNA, Messenger; D011983:Receptors, Purinergic; D000241:Adenosine