title: Diagnostic tests for Helicobacter pylori: comparison and influence of non-steroidal anti-inflammatory drugs.
abstract: OBJECTIVE
  To evaluate the efficacy of culture, histology, CLO-test, Helico-G and Pyloriset tests in diagnosing Helicobacter pylori in the presence or absence of non-steroidal anti-inflammatory drugs (NSAIDs).
  
  
  METHODS
  Of 134 patients studied, 75 had taken NSAIDs. At endoscopy, biopsy specimens were taken for culture, histology, and CLO-test. Blood was also taken for enzyme linked immunosorbent assay (ELISA) (Helico-G) and latex agglutination (Pyloriset) tests.
  
  
  RESULTS
  The sensitivity, specificity, and predictive values of histology and CLO-test, compared with culture, ranged from 90% to 97%, regardless of NSAID intake. In the 59 patients not taking NSAIDs Helico-G had a sensitivity of 75% (p < 0.05) and a specificity of 61%; Pyloriset's sensitivity and specificity were, respectively, 63% (p < 0.05) and 67%. In the 75 patients taking NSAIDs the sensitivity of Helico-G was 81% and its specificity 45% (p < 0.05); Pyloriset had a sensitivity of 61% (p < 0.05) and a specificity of 50% (p < 0.05).
  
  
  CONCLUSIONS
  These findings suggest that H pylori is more reliably diagnosed by culture, histology, and CLO-test than by the serological tests used in this study, especially in patients treated with NSAIDs.
authors.affiliation: Department of Gastroenterology, Royal Infirmary, Glasgow.
authors.forename: A S
authors.initials: AS
authors.lastname: Taha
authors.forename: P
authors.initials: P
authors.lastname: Boothman
authors.forename: I
authors.initials: I
authors.lastname: Nakshabendi
authors.forename: J
authors.initials: J
authors.lastname: Reid
authors.forename: C
authors.initials: C
authors.lastname: Morran
authors.forename: C G
authors.initials: CG
authors.lastname: Gemmell
authors.forename: F D
authors.initials: FD
authors.lastname: Lee
authors.forename: R D
authors.initials: RD
authors.lastname: Sturrock
authors.forename: R I
authors.initials: RI
authors.lastname: Russell
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D005756:Gastritis / Q000473:pathology; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000188:drug therapy; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D013276:Stomach Ulcer / Q000188:drug therapy / Q000473:pathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007074:Immunoglobulin G