title: Production and specificity of anti-22-oxacalcitriol antisera.
abstract: 22-Oxacalcitriol 3-hemiglutarate, a haptenic derivative of 22-oxacalcitriol, was synthesized to obtain a specific antibody for use in radioimmunoassay. Three antisera were elicited in rabbits against the hapten conjugated with bovine serum albumin, and their specificity was examined by cross-reaction study. One of the antisera was found to be satisfactorily specific, and expected to provide a radioimmunoassay useful for the pharmacokinetic study of 22-oxacalcitriol.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kanazawa University, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Kobayashi
authors.forename: T
authors.initials: T
authors.lastname: Asano
authors.forename: J
authors.initials: J
authors.lastname: Kitahori
authors.forename: K
authors.initials: K
authors.lastname: Shimada
authors.forename: N
authors.initials: N
authors.lastname: Kubodera
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
mesh_terms: D000818:Animals; D000906:Antibodies / Q000032:analysis*; D000918:Antibody Specificity; D002117:Calcitriol / Q000031:analogs & derivatives* / Q000097:blood / Q000276:immunology; D005260:Female; D011817:Rabbits; D011863:Radioimmunoassay
chemical_list: D000906:Antibodies; C077050:22-oxacalcitriol-3-hemiglutarate; D002117:Calcitriol; C051883:maxacalcitol