Brainstem glioma after radiation therapy for acute myeloblastic leukemia in a child with Down syndrome. Possible pathogenetic mechanisms.
A 13-year-old boy with Down syndrome (DS) had a brainstem glioma confirmed at autopsy, 10 years after receiving prophylactic cranial irradiation for acute myeloblastic leukemia. There is no clear association of brain tumors with DS; despite a reported link between leukemia and glioma, a causal association with radiation therapy is more likely.
Zagzag
D
D
Department of Pathology, New York University Medical Center, NY 10016.
Miller
D C
DC
Cangiarella
J
J
Allen
J C
JC
Greco
M A
MA
D000293:Adolescent; D001921:Brain / Q000033:anatomy & histology; D001933:Brain Stem / Q000473:pathology*; D016371:Cranial Irradiation / Q000009:adverse effects*; D004314:Down Syndrome / Q000150:complications*; D005910:Glioma / Q000209:etiology*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000209:etiology / Q000532:radiotherapy*; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D016609:Neoplasms, Second Primary / Q000209:etiology