title: Lp(a) levels in patients undergoing aorto-coronary bypass surgery.
abstract: The aims of this study were to evaluate plasma lipid, apoprotein and Lp(a) levels in patients with severe coronary atherosclerosis undergoing aorto-coronary bypass surgery (BP) and to relate these parameters to the involvement of one or more vessels. Seventy-seven male patients and 77 cardiovascular disease-free controls, matched for sex, age and body weight were studied. Higher triglyceride and apo B levels with lower HDL-cholesterol and apo A-I levels were found in BP patients in comparison with the controls. Lp(a) levels were slightly, but not significantly, increased. Moreover BP patients presented a significantly higher prevalence of HDL-cholesterol levels below 35 mg dl-1 (49.3% vs 22.1%) and Lp(a) levels above 70 mg dl-1 (10.4% vs 1.3%) than the controls. When patients were divided according to the number of coronary vessels involved (one, two or three), no significant difference was found, with a trend to increase in Lp(a) mean levels and in prevalence of Lp(a) levels above 30 and 70 mg dl-1 in more severely diseased patients. These results suggest that patients with severe coronary artery disease undergoing aorto-coronary bypass surgery show low HDL-cholesterol levels with high triglyceride levels. Moreover Lp(a) levels above 70 mg dl-1 are highly associated with severe coronary vessel stenosis.
authors.affiliation: Istituto di Medicina Interna e Geriatria, Università di Palermo, Italy.
authors.forename: M R
authors.initials: MR
authors.lastname: Averna
authors.forename: C M
authors.initials: CM
authors.lastname: Barbagallo
authors.forename: S
authors.initials: S
authors.lastname: Ocello
authors.forename: O
authors.initials: O
authors.lastname: Doria
authors.forename: G
authors.initials: G
authors.lastname: Davì
authors.forename: V
authors.initials: V
authors.lastname: Scafidi
authors.forename: R
authors.initials: R
authors.lastname: Albiero
authors.forename: A
authors.initials: A
authors.lastname: Notarbartolo
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D016632:Apolipoprotein A-I / Q000378:metabolism; D001055:Apolipoproteins B / Q000097:blood; D016009:Chi-Square Distribution; D008076:Cholesterol, HDL / Q000097:blood; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000097:blood / Q000473:pathology / Q000601:surgery; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
chemical_list: D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D017270:Lipoprotein(a); D014280:Triglycerides