Retention of perfluorochemicals in rat liver and spleen.
The uptake and retention of perfluorochemicals (PFCs) into rat liver and spleen have been measured for up to 28 d following injection of either the commercial PFC emulsion, Fluosol, or a novel perfluorodecalin (FDC)-based emulsion. Both quantitative and qualitative differences in the retention of individual PFCs were observed, depending on composition of emulsion administered. Nevertheless, uptake of PFCs into the spleen was consistently greater than into the liver, irrespective of formulation injected.
Lowe
K C
KC
Department of Life Science, University of Nottingham, U.K.
Bentley
P K
PK
D000818:Animals; D001693:Biological Transport, Active; D001802:Blood Substitutes / Q000493:pharmacokinetics*; D004655:Emulsions; D005466:Fluorocarbons / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000378:metabolism*; D014018:Tissue Distribution
D001802:Blood Substitutes; D004655:Emulsions; D005466:Fluorocarbons; C050455:fluosol