title: Plasma membrane redox activity correlates with N-myc expression in neuroblastoma cells.
abstract: In different neuroblastoma cell lines and transfected clones, an increasing plasma membrane redox activity correlates with amplification and enhanced expression of the N-myc oncogene. Furthermore, plasma membrane redox activity is partially inhibited by retinoic acid in neuroblastoma cells with multiple copies of the N-myc oncogene but not in neuroblastoma cells with only one copy of this gene.
authors.affiliation: Sektion Onkologie/Immunologie, Ruprecht-Karls-Universität, Heidelberg, Germany.
authors.forename: M A
authors.initials: MA
authors.lastname: Medina
authors.forename: A
authors.initials: A
authors.lastname: del Castillo-Olivares
authors.forename: L
authors.initials: L
authors.lastname: Schweigerer
mesh_terms: D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology; D005784:Gene Amplification; D016259:Genes, myc; D006801:Humans; D009447:Neuroblastoma / Q000235:genetics* / Q000378:metabolism; D010084:Oxidation-Reduction; D014162:Transfection; D014212:Tretinoin / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D016222:Fibroblast Growth Factor 2; D014212:Tretinoin