title: Inhibition of mutagenesis by p-aminobenzoic acid as a nitrite scavenger.
abstract: Nitrite treatment enhances the direct-acting mutagenicity of various foodstuffs (e.g., chicken, bloater, the soybean flour 'kinako', and Ban-Ban-Chi sauce) on Salmonella typhimurium TA100. p-Aminobenzoic acid (PABA) and glutathione (GSH) reduced this mutagenicity; on the other hand, thioproline (TPRO) increased it. PABA seemed more effective than TPRO in scavenging nitrite ion. In analysis of the reactions of PABA and sodium nitrite under acidic conditions (pH 3.0), p-hydroxybenzoic acid (PHBA) was identified as a major reaction product. The reaction seems to involve two steps, diazotization and diazonium substitution. PHBA was not mutagenic to four strains (TA97, TA98, TA100 and TA102) of S. typhimurium with or without S9 mix.
authors.affiliation: Institute for Fundamental Research, Suntory Limited, Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kako
authors.forename: Y
authors.initials: Y
authors.lastname: Toyoda
authors.forename: Y
authors.initials: Y
authors.lastname: Hatanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Suwa
authors.forename: H
authors.initials: H
authors.lastname: Nukaya
authors.forename: M
authors.initials: M
authors.lastname: Nagao
mesh_terms: D010129:4-Aminobenzoic Acid / Q000494:pharmacology*; D005504:Food Analysis; D005978:Glutathione / Q000494:pharmacology*; D016296:Mutagenesis / Q000187:drug effects*; D009152:Mutagenicity Tests; D009573:Nitrites / Q000037:antagonists & inhibitors*; D012486:Salmonella typhimurium / Q000187:drug effects; D013844:Thiazoles / Q000494:pharmacology*; D053778:Thiazolidines
chemical_list: D009573:Nitrites; D013844:Thiazoles; D053778:Thiazolidines; C003438:thiazolidine-4-carboxylic acid; D005978:Glutathione; D010129:4-Aminobenzoic Acid