Biological properties of interleukin 10.
An enormous amount of information on interleukin 10 (IL-10) has been gathered since its original description as cytokine synthesis inhibition factor (CSIF) several years ago. In this short article, Maureen Howard and Anne O'Garra summarize what is currently known of the biological properties of IL-10 and speculate on its clinical potential.
Howard
M
M
DNAX Research Institute, Palo Alto, CA 94304-1104.
O'Garra
A
A
D000818:Animals; D000938:Antigen-Presenting Cells / Q000187:drug effects; D001402:B-Lymphocytes / Q000187:drug effects*; D016207:Cytokines / Q000502:physiology; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects*; D016753:Interleukin-10 / Q000494:pharmacology / Q000502:physiology*; D008213:Lymphocyte Activation / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects*
D016207:Cytokines; D016753:Interleukin-10