Glucagon-like peptide-1(7-37)/(7-36)amide is a new incretin.
Glucagon-like peptide-1 (GLP-1) is the main product of the intestinal processing of proglucagon. It is released from the intestinal K-cells into the circulation in response to the oral ingestion of food. At the pancreatic beta cell GLP-1 is a potent insulin secretagogue in the presence of elevated glucose levels, defining glucagon-like peptide-1 as a new incretin. Its action is mediated by specific receptors coupled to the adenylate cyclase system by a stimulatory G-protein. Finally, glucagon-like peptide-1 stimulates proinsulin gene expression and it is thus involved at several levels in the regulation of insulin synthesis and secretion.
Fehmann
H C
HC
Department of Internal Medicine, Philipps University of Marburg, Germany.
Göke
R
R
Göke
B
B
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001665:Binding Sites; D019004:Galanin; D005786:Gene Expression Regulation; D005934:Glucagon / Q000378:metabolism / Q000502:physiology*; D052216:Glucagon-Like Peptide 1; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007413:Intestinal Mucosa / Q000166:cytology / Q000378:metabolism*; D007515:Islets of Langerhans / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism / Q000502:physiology*; D010455:Peptides / Q000502:physiology; D011384:Proinsulin / Q000235:genetics; D011498:Protein Precursors / Q000378:metabolism / Q000502:physiology*; D013004:Somatostatin / Q000378:metabolism
D007328:Insulin; D010446:Peptide Fragments; D010455:Peptides; D011498:Protein Precursors; D013004:Somatostatin; D019004:Galanin; D052216:Glucagon-Like Peptide 1; D005934:Glucagon; D011384:Proinsulin; D000262:Adenylyl Cyclases