cDNA sequence for rat dermatan sulfate proteoglycan-II (decorin).
A cDNA clone for dermatan sulfate proteoglycan-II, or decorin, has been isolated from a rat uterus library and sequenced. The cDNA and deduced amino acid sequences are 79 and 77% identical to the previously reported human and bovine sequences, respectively. The rat protein contains potential attachment sites for two glycosaminoglycan chains and four N-linked oligosaccharides, six conserved cysteine residues and multiple repeats of a leucine-rich sequence, LXXLXLXXNXL/I. Overlapping the C-end of one of these repeats is an NKISK sequence, which has been implicated in binding to fibronectin.
Abramson
S R
SR
Department of Biochemistry and Molecular Biology, REPSCEND Labs, University of Miami School of Medicine, FL 33101.
Woessner
J F
JF
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004247:DNA; D058575:Decorin; D016326:Extracellular Matrix Proteins; D005260:Female; D006801:Humans; D008969:Molecular Sequence Data; D011509:Proteoglycans / Q000235:genetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017386:Sequence Homology, Amino Acid; D014599:Uterus / Q000378:metabolism
C546878:DCN protein, human; C546880:Dcn protein, rat; D058575:Decorin; D016326:Extracellular Matrix Proteins; D011509:Proteoglycans; D004247:DNA