[T-lineage acute lymphoblastic leukemia. Report of 23 cases].
23 cases of T-lineage acute lymphoblastic leukemia (TALL) were identified by multiple monoclonal antibodies. TALL was characterized by a younger age of the patients (average age 28 years), strong male preponderance (M:F, 4.8: 1), mediastinal mass (19%), higher leucocyte count (71.4%), hepatomegaly (76.2%) and splenomegaly (90.5%). Of 19 cases of TALL who were subclassified according to the criteria for subclassification of TALL proposed by Reinherz, 10 cases expressed a surface antigen pattern consistent with the early thymocyte stage of TALL development, 8 cases were of common thymocyte stage and 1 case was of mature thymocyte stage. The phenotypes of TALL cells appear to be considerably heterogeneous. 12 of 18 patients who received chemotherapy had achieved complete remission (67%).
Zhu
K G
KG
First Affiliated Hospital, Zhejiang Medical University.
Zhou
S W
SW
Lin
M F
MF
D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000145:classification / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011379:Prognosis
D000911:Antibodies, Monoclonal