IgM M-protein in a patient with sensory-dominant neuropathy binds preferentially to polysialogangliosides.
A 77-year-old man presented sensory-dominant neuropathy associated with IgM M-protein reacting with various gangliosides. The M-protein bound to gangliosides with polysialosyl residue, such as GD1b, GD3, GT1b, GT3, GQ1b, and GQ1c. In addition, GD1a, GM3 and LM1, having a terminal monosialosyl epitope, were also recognized. Previously, Ilyas et al. described a similar case in which sensory symptoms were associated with IgM M-protein reacting with gangliosides containing a disialosyl group, such as GD3, GD1b, and GT1b, but not GM3 and GD1a. It is suggested that the reactivity of IgM M-protein with polysialogangliosides may be associated with the pathogenesis of sensory-dominant neuropathy.
Obi
T
T
Department of Neurology, National Shizuoka Hospital, Japan.
Kusunoki
S
S
Takatsu
M
M
Mizoguchi
K
K
Nishimura
Y
Y
D000368:Aged; D002855:Chromatography, Thin Layer; D004797:Enzyme-Linked Immunosorbent Assay; D005732:Gangliosides / Q000276:immunology*; D006017:Glycolipids / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000378:metabolism*; D008222:Lymphokines / Q000378:metabolism*; D008297:Male; D009185:Myelin Proteins / Q000378:metabolism*; D018992:Myelin-Associated Glycoprotein; D010525:Peripheral Nerves / Q000276:immunology / Q000473:pathology; D029584:Prostatic Secretory Proteins; D012678:Sensation Disorders / Q000175:diagnosis / Q000276:immunology*
D005732:Gangliosides; D006017:Glycolipids; D007075:Immunoglobulin M; D008222:Lymphokines; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D029584:Prostatic Secretory Proteins; C043076:beta-microseminoprotein; C013059:immunoglobulin-binding factors; C025447:sialogangliosides