Alteration of arteriolar responses to serotonin by two intravenous anesthetics.
The effects of serotonin (5-HT) on the microvasculature of cremaster muscles were compared in decerebrate, ketamine- and pentobarbital-anesthetized rats. 5-HT-induced constriction of large distributing arterioles was enhanced in the ketamine- and pentobarbital-anesthetized rats. Precapillary arterioles of pentobarbital-anesthetized animals were more sensitive to 5-HT-induced dilation than either decerebrate or ketamine-anesthetized animals. The response of vessels to two 5-HT receptor antagonists (methysergide and LY53857) were unchanged by the anesthetics. Our findings suggest that both ketamine and pentobarbital enhance the microvascular response to 5-HT, but that these changes are not due to an alteration of receptor sensitivity.
Asher
E F
EF
Department of Anesthesiology, School of Medicine University of Louisville, KY 40292.
Alsip
N L
NL
Zhang
P Y
PY
Harris
P D
PD
D000777:Anesthetics / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D001160:Arterioles / Q000187:drug effects*; D003655:Decerebrate State; D004873:Ergolines / Q000494:pharmacology; D007275:Injections, Intravenous; D007649:Ketamine / Q000494:pharmacology; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D009994:Osmolar Concentration; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000494:pharmacology*; D012702:Serotonin Antagonists; D014661:Vasoconstriction; D014664:Vasodilation
D000777:Anesthetics; D004873:Ergolines; D012702:Serotonin Antagonists; D012701:Serotonin; D007649:Ketamine; D010424:Pentobarbital; C032663:LY 53857; D008784:Methysergide