title: Functional homology between N-myc and c-myc in murine plasmacytomagenesis: plasmacytoma development in N-myc transgenic mice.
abstract: Mouse plasmacytomas induced by pristane oil alone, or in combination with Abelson murine leukemia virus (A-MuLV), regularly carry one of three alternative chromosomal translocations that juxtapose c-myc to immunoglobulin heavy- or light-chain loci. E mu-c-myc transgenic mice develop translocation-free plasmacytomas after induction by pristane oil and/or A-MuLV [Sugiyama, H., Silva, S., Wang, Y., Weber, G., Babonits, M., Rosen, A., Wiener, F. & Klein, G. (1990). Int. J. Cancer, 46, 845-852]. In order to test whether another member of the myc family, N-myc, could play a similar role as c-myc, we treated E mu-N-myc transgenic mice with pristane and helper-free A-MuLV. Of 20 mice that received a single pristane injection followed by A-MuLV, 17 developed plasmacytomas with a mean latency period of 54 +/- 20 days. In a corresponding group that only received a single pristane injection, five out of six transgenic mice developed plasmacytomas with a mean latency period of 142 +/- 32 days. However, after three monthly injections of pristane, all 15 transgenic mice developed plasmacytomas with a mean latency period of 128 +/- 20 days. All plasmacytomas expressed the N-myc transgene, while none of them expressed either c-myc or endogenous N-myc. None of the tumors carried the usual plasmacytoma-associated translocations.
authors.affiliation: Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Sugiyama
authors.forename: H
authors.initials: H
authors.lastname: Axelson
authors.forename: C K
authors.initials: CK
authors.lastname: Panda
authors.forename: M
authors.initials: M
authors.lastname: Babonits
authors.forename: A
authors.initials: A
authors.lastname: Ma
authors.forename: J M
authors.initials: JM
authors.lastname: Steinberg
authors.forename: F W
authors.initials: FW
authors.lastname: Alt
authors.forename: G
authors.initials: G
authors.lastname: Klein
authors.forename: F
authors.initials: F
authors.lastname: Wiener
mesh_terms: D000011:Abelson murine leukemia virus / Q000235:genetics*; D000818:Animals; D002273:Carcinogens; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D004273:DNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D004742:Enhancer Elements, Genetic; D005803:Genes, Immunoglobulin; D016259:Genes, myc; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007147:Immunoglobulin Light Chains / Q000235:genetics; D007438:Introns; D051379:Mice; D008822:Mice, Transgenic; D010954:Plasmacytoma / Q000139:chemically induced / Q000235:genetics* / Q000473:pathology; D012313:RNA / Q000235:genetics / Q000302:isolation & purification; D012334:RNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D013729:Terpenes; D014178:Translocation, Genetic
chemical_list: D002273:Carcinogens; D004273:DNA, Neoplasm; D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D012334:RNA, Neoplasm; D013729:Terpenes; C009042:pristane; D012313:RNA; D004247:DNA