title: Genetic linkage analysis of the murine developmental mutant velvet coat (Ve) and the distal chromosome 15 developmental genes Hox-3.1, Rar-g, Wnt-1, and Krt-2.
abstract: We have identified restriction fragment length polymorphisms between Mus musculus and Mus spretus for the Chromosome 15 loci Hox-3, Wnt-1, Krt-2, Rar-g, and Ly-6. We followed the inheritance of these alleles in interspecific genetic test crosses between velvet coat (Ve) heterozygotes and M. spretus. The results suggest a gene order and recombination distances (in cM) of Ly-6-22-Wnt-1-2-Ve/Krt-2/Rar-g-3-Hox-3. No recombination was found between Ve, Krt-2, and Rar-g. The data also provide evidence for the hypothesis of a large-scale genomic duplication involving homologous gene pairs on mouse Chromosomes 15 and 11.
authors.affiliation: Department of Biology, Yale University, New Haven, Connecticut 06511.
authors.forename: C P
authors.initials: CP
authors.lastname: Hart
authors.forename: J G
authors.initials: JG
authors.lastname: Compton
authors.forename: S H
authors.initials: SH
authors.lastname: Langley
authors.forename: L
authors.initials: L
authors.lastname: Hunihan
authors.forename: K P
authors.initials: KP
authors.lastname: LeClair
authors.forename: A
authors.initials: A
authors.lastname: Zelent
authors.forename: T H
authors.initials: TH
authors.lastname: Roderick
authors.forename: F H
authors.initials: FH
authors.lastname: Ruddle
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000235:genetics; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D005796:Genes; D050437:Genes, Developmental; D005801:Genes, Homeobox; D008040:Genetic Linkage; D006197:Hair; D018398:Homeodomain Proteins; D007633:Keratins / Q000235:genetics; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009154:Mutation; D012150:Polymorphism, Restriction Fragment Length; D011518:Proto-Oncogene Proteins / Q000235:genetics; D018168:Receptors, Retinoic Acid; D051153:Wnt Proteins; D051155:Wnt1 Protein; D029961:Zebrafish Proteins
chemical_list: D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; C489816:Hoxc8 protein, mouse; D011518:Proto-Oncogene Proteins; D018168:Receptors, Retinoic Acid; D051153:Wnt Proteins; D051155:Wnt1 Protein; C495246:Wnt1 protein, mouse; D029961:Zebrafish Proteins; D007633:Keratins