title: Sternocleidomastoid muscle contractility at different levels of isoflurane anaesthesia in humans.
abstract: We have measured force-frequency curves of the sternocleidomastoid muscle in six patients at three different levels of isoflurane anaesthesia (1.0, 1.4 and 1.8 MAC). Spontaneous ventilation was suppressed by mild hypocapnia induced by mechanical ventilation. An anterior force vector of the sternocleidomastoid muscle was measured during isometric contraction induced by supramaximal electrical stimulation at 20, 50 and 100 Hz to the i.m. accessory nerves of the muscle. The force response at 20 Hz and 50 Hz did not change with an increase in isoflurane concentration, but it decreased at 100 Hz as isoflurane concentration increased. The reduction in the force at 100 Hz may be caused mainly by impaired neuromuscular transmission.
authors.affiliation: Department of Anaesthesiology and Critical Care Medicine, School of Medicine, Tokyo Medical and Dental University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Oshima
authors.forename: H
authors.initials: H
authors.lastname: Toyooka
authors.forename: K
authors.initials: K
authors.lastname: Amaha
mesh_terms: D000293:Adolescent; D000328:Adult; D000769:Anesthesia, Inhalation; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007530:Isoflurane / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects*; D009334:Neck Muscles / Q000187:drug effects* / Q000502:physiology
chemical_list: D007530:Isoflurane