The emerging neuropoietic cytokine family: first CDF/LIF, CNTF and IL-6; next ONC, MGF, GCSF?
CDF/LIF is a polyfunctional cytokine that shares a remarkable overlap with ciliary neurotrophic factor in its actions on neurons, and with interleukin-6 in its actions on other tissues. Moreover, the receptors for this cytokine, as well as those for ciliary neurotrophic factor, share homology with the subunits of the interleukin-6 receptor. The predicted structural similarity of these proteins with oncostatin M, myelomonocytic growth factor and granulocyte colony-stimulating factor, as well as at least a partial overlap in biological activities, is now prompting further examination of their roles in neuronal gene expression.
Patterson
P H
PH
Biology Division, California Institute of Technology, Pasadena 91125.
D000818:Animals; D030161:Avian Proteins; D020934:Ciliary Neurotrophic Factor; D016207:Cytokines / Q000502:physiology*; D006131:Growth Inhibitors / Q000502:physiology; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D015850:Interleukin-6 / Q000502:physiology; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D053683:Oncostatin M; D010455:Peptides / Q000502:physiology; D016188:Receptors, Granulocyte Colony-Stimulating Factor / Q000502:physiology
D030161:Avian Proteins; D020934:Ciliary Neurotrophic Factor; D016207:Cytokines; D006131:Growth Inhibitors; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D015850:Interleukin-6; C507837:LIF protein, human; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines; C059626:MGF protein, chicken; D009419:Nerve Tissue Proteins; C508351:OSM protein, human; D010455:Peptides; D016188:Receptors, Granulocyte Colony-Stimulating Factor; D053683:Oncostatin M