title: Isochromosome 1q in acute monocytic leukemia: a new nonrandom association.
abstract: We report a case of de novo acute monocytic leukemia in a 25-year-old man in whom the sole clonal cytogenetic abnormality was an additional isochromosome 1q. Cytogenetic polymorphisms indicate that, in addition to the formation of the isochromosome, a duplication of the remaining normal chromosome 1 had taken place. Other reported cases suggest an association between acute monocytic leukemia and i(1q).
authors.affiliation: Department of Haematology, Royal Free Hospital and Medical School, London, United Kingdom.
authors.forename: J M
authors.initials: JM
authors.lastname: Hawkins
authors.forename: M
authors.initials: M
authors.lastname: Wood
authors.forename: F
authors.initials: F
authors.lastname: Wright
authors.forename: L M
authors.initials: LM
authors.lastname: Secker-Walker
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000235:genetics*; D008297:Male