title: In vivo activity of novel sulphonic derivatives of distamycin A.
abstract: Solid tumor growth can be modulated through inhibition of vascularization elicited by angiogenic factors. With the objective to complex these factors, new derivatives of distamycin A were synthesized and evaluated in vitro [1] and in vivo for their ability, after i.v. administration, to inhibit bFGF-induced vascularization and the growth of M5076 murine reticulosarcoma implanted i.m. The tested compounds were able to block angiogenesis with inhibition values ranging between 70-100%. Moreover, they were found to be capable of inducing tumor inhibition with values ranging between 40% and 95% at non-toxic doses.
authors.affiliation: Farmitalia Carlo Erba, Erbamont Group, Research and Development Center, Nerviano, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Sola
authors.forename: G
authors.initials: G
authors.lastname: Biasoli
authors.forename: E
authors.initials: E
authors.lastname: Pesenti
authors.forename: M
authors.initials: M
authors.lastname: Farao
authors.forename: P
authors.initials: P
authors.lastname: Della Torre
authors.forename: N
authors.initials: N
authors.lastname: Mongelli
authors.forename: M
authors.initials: M
authors.lastname: Grandi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003094:Collagen; D004214:Distamycins / Q000627:therapeutic use*; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009389:Neovascularization, Pathologic / Q000473:pathology / Q000517:prevention & control*; D019736:Prostheses and Implants; D013329:Structure-Activity Relationship; D013451:Sulfonic Acids / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D004214:Distamycins; D013451:Sulfonic Acids; D016222:Fibroblast Growth Factor 2; C030000:stallimycin; D003094:Collagen