title: Impaired iron status in rats as induced by copper deficiency.
abstract: The hypothesis was tested that marginal copper deficiency affects iron status. Copper restriction (1 vs 5 mg Cu/kg diet) significantly lowered iron concentrations and transferrin saturation in plasma and reduced blood hemoglobin, hematocrit, and iron concentrations in tibia and femur, but raised iron concentrations in liver. Marginal copper deficiency did not affect feed intake and bodyweight gain.
authors.affiliation: Interfaculty Reactor Institute, University of Technology, Delft, The Netherlands.
authors.forename: G J
authors.initials: GJ
authors.lastname: Van Den Berg
authors.forename: F
authors.initials: F
authors.lastname: Van Houwelingen
authors.forename: A G
authors.initials: AG
authors.lastname: Lemmens
authors.forename: A C
authors.initials: AC
authors.lastname: Beynen
mesh_terms: D000818:Animals; D001835:Body Weight; D003300:Copper / Q000172:deficiency*; D004435:Eating; D005269:Femur / Q000737:chemistry; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D007501:Iron / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000737:chemistry; D008297:Male; D009752:Nutritional Status; D051381:Rats; D017208:Rats, Wistar; D013977:Tibia / Q000737:chemistry; D014168:Transferrin / Q000378:metabolism
chemical_list: D006454:Hemoglobins; D014168:Transferrin; D003300:Copper; D007501:Iron