Favorable clinical effects of iloprost infusion in 4 uremic patients with critical limb ischemia.
Four uremic patients with advanced peripheral arterial occlusive disease (PAOD) of lower limbs causing rest pain and ischemic-necrotic lesions were treated with a four-hour intravenous infusion of iloprost at doses of 0.75-2.5 ng/kg/min for twenty-eight days. After a week of the therapy all patients experienced disappearance of rest pain and prolonged walking distance. At the end of the trial a diabetic patient showed a complete regression of the necrotic areas of two toes while the other patients still showed ischemic-necrotic foot lesions that were well demarcated. Iloprost therapy can be effective in uremic patients with severe PAOD.
Bedani
P L
PL
Division of Nephrology, S. Anna Hospital, Ferrara, Italy.
Perini
L
L
Farinelli
R
R
Fabbian
F
F
Fiocchi
O
O
Guerra
S
S
Vanini
A
A
Gilli
P
P
D000208:Acute Disease; D001132:Arm / Q000098:blood supply*; D004341:Drug Evaluation; D006801:Humans; D016285:Iloprost / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D007511:Ischemia / Q000188:drug therapy* / Q000209:etiology; D007866:Leg / Q000098:blood supply*; D009336:Necrosis; D012074:Remission Induction; D014034:Toes / Q000098:blood supply / Q000473:pathology; D014511:Uremia / Q000150:complications / Q000188:drug therapy*
D016285:Iloprost