[Formation of alcohol motivation under blockade of protein synthesis by cycloheximide].
The influence of protein blocker cycloheximide on ethanol intake in rats under condition of development of alcohol motivation was studied. It was found that intracerebroventricular injection of cycloheximide caused inhibition of alcohol intake in rats which had free choice between water and 20% ethanol solution. The blockade action of cycloheximide on the development of alcohol motivation was dependent on initial preference of ethanol in rats and was more strong in rats with originally low preference for ethanol.
Timofeeva
L V
LV
Anuchina
N M
NM
D000427:Alcohol Deterrents / Q000008:administration & dosage / Q000494:pharmacology*; D000428:Alcohol Drinking; D000818:Animals; D003513:Cycloheximide / Q000008:administration & dosage / Q000494:pharmacology*; D004326:Drinking; D007276:Injections, Intraventricular; D008297:Male; D009042:Motivation; D051381:Rats
D000427:Alcohol Deterrents; D003513:Cycloheximide