title: The role of second look laparotomy and tumor markers in the follow-up of endodermal sinus tumor of the ovary. A case report and review of the literature.
abstract: Endodermal sinus tumor (EST) of the ovary is extremely rare and little information exists about therapy and the role of second-look laparotomy in the management of this entity. A case of EST of the ovary in a 21 year old woman is reported. She received conservative surgery and six courses of combination therapy consisting of Vincristine, Actinomycin D and Cyclophosphamide before second-look laparotomy. Due to progression of the disease second-line polychemotherapy with Vinblastine, Bleomycin and Cisplatin was administered. This new regimen reduced the alpha-fetoprotein to normal levels although the patient was not free of disease on second-look laparotomy. Precise guidelines for the management of this disease, especially in advanced stages, are still lacking.
authors.affiliation: Gynaecologic Oncology Department, Hospital of Cruces, University of the Basque Country, Vizcaya, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Barrenetxea
authors.forename: J
authors.initials: J
authors.lastname: Schneider
authors.forename: M
authors.initials: M
authors.lastname: Martín-Mateos
authors.forename: M
authors.initials: M
authors.lastname: Fraca
authors.forename: J C
authors.initials: JC
authors.lastname: Matía
authors.forename: F J
authors.initials: FJ
authors.lastname: Rodríguez-Escudero
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006801:Humans; D007813:Laparotomy; D008649:Mesonephroma / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D012086:Reoperation; D000509:alpha-Fetoproteins / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; D000509:alpha-Fetoproteins