title: Circulating immune complexes in leukaemias and lymphomas.
abstract: Circulating immune complexes (ClC) were estimated in 78 patients of leukaemias and lymphomas by Clq deviation ELISA and PEG assay. In all leukaemias a significant elevation in ClC was seen at the time of first presentation. While in ALL a decrease occurred on therapy as partial or complete remission was achieved, no such fall was seen in AML or CML-BC when treated. ClC levels were much higher in non-Hodgkins lymphoma than in Hodgkins disease and showed a direct correlation with B symptoms and activity of the disease. The ClC levels were highest in null-ALL followed by those in common ALL and T-ALL. The mean duration of remission in patients of ALL without elevation in ClC was much longer than in those with ClC.
authors.affiliation: Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow.
authors.forename: J
authors.initials: J
authors.lastname: Kishore
authors.forename: R
authors.initials: R
authors.lastname: Kumar
authors.forename: V P
authors.initials: VP
authors.lastname: Choudhry
authors.forename: M
authors.initials: M
authors.lastname: Bhargava
mesh_terms: D000936:Antigen-Antibody Complex / Q000032:analysis / Q000097:blood / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D002845:Chromatography; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D016130:Immunophenotyping; D007938:Leukemia / Q000145:classification / Q000175:diagnosis / Q000276:immunology*; D008223:Lymphoma / Q000175:diagnosis / Q000276:immunology*; D008297:Male; D011379:Prognosis
chemical_list: D000936:Antigen-Antibody Complex