Tissue responses to Hydron, assessed by intramuscular implantation.
Freshly mixed polymerized Hydron root canal filling material, fully set AH26 and Teflon were implanted in the quadriceps muscle of guinea pigs and assessed histologically at 2 days, 1, 2, 3, 12 and 26 weeks after implantation. All materials were characterized by peri-implant fibrous connective tissue capsule formation. Von Kossa-positive calcific material was observed at the implant-tissue interface of Hydron implants. The amount of apparently calcified material increased with time. Inflammation was not a prominent tissue response for any of the test materials, nor was a foreign body giant cell response.
Reid
R J
RJ
The University of Adelaide, South Australia.
Wilson
D F
DF
Chau
K K
KK
Heithersay
G S
GS
Heijkoop
P S
PS
D000818:Animals; D001672:Biocompatible Materials; D001729:Bismuth / Q000633:toxicity; D004338:Drug Combinations; D004853:Epoxy Resins; D005549:Foreign-Body Reaction; D006168:Guinea Pigs; D020100:Hydrogels; D007249:Inflammation / Q000139:chemically induced; D008262:Macrophage Activation; D008297:Male; D008422:Materials Testing; D008709:Methenamine / Q000633:toxicity; D009132:Muscles / Q000187:drug effects*; D011102:Polyhydroxyethyl Methacrylate / Q000031:analogs & derivatives* / Q000633:toxicity; D011138:Polytetrafluoroethylene / Q000633:toxicity; D019736:Prostheses and Implants; D012387:Root Canal Filling Materials / Q000633:toxicity*; D012834:Silver / Q000633:toxicity; D014025:Titanium / Q000633:toxicity
D001672:Biocompatible Materials; D004338:Drug Combinations; D004853:Epoxy Resins; D020100:Hydrogels; D012387:Root Canal Filling Materials; C000257:polyhydroxyethyl methacrylate hydrogels; D011102:Polyhydroxyethyl Methacrylate; D012834:Silver; C028044:epoxy resin AH-26; D011138:Polytetrafluoroethylene; D014025:Titanium; D008709:Methenamine; D001729:Bismuth