Protein V, a novel type-II IgG receptor from Streptococcus sp.: sequence, homologies and putative Fc-binding site.
We have cloned and sequenced the Fc-receptor-encoding gene, fcrV, from a group G streptococcus. Considerable similarity was revealed between the FcRV, FcRA76 and M proteins of group A streptococci in their signal sequences and 3' termini, and between the Fc-binding regions of FcRV and FcRA76. The promoter and terminator regions showed no homology with those of the fcrA76 and M protein-encoding genes. The A1-A4 domains of FcrV (protein V) exhibit a heptapeptide repeat motif which is characteristic of alpha-helical coiled-coil proteins. The sequence, Ser-Asn-Arg-Ala-Ala, in the outer position, 'f' of each domain is highly conserved and may be involved in FcR-IgG interactions.
Smirnov OYu
Institute of Immunology, State Concern Biopreparation, Moscow Region, Russia.
Denesyuk
A I
AI
Zakharov
M V
MV
Abramov
V M
VM
Zav'yalov
V P
VP
D000595:Amino Acid Sequence; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics*; D001483:Base Sequence; D002352:Carrier Proteins; D003001:Cloning, Molecular; D008969:Molecular Sequence Data; D017452:Receptors, IgG / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D013291:Streptococcus / Q000235:genetics*
D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; D017452:Receptors, IgG; C014689:streptococcal M protein; C077032:FcrV protein, Streptococcus