Renal renin secretion rate and norepinephrine secretion rate in response to centrally administered angiotensin-II: role of the medial basal forebrain.
The influence that centrally administered angiotensin-II (ANG-II) and saralasin (SAR) has on renal norepinephrine secretion rate (NESR) and renal renin secretion rate (RSR) were studied. Rats were given thermal lesions of the medial basal forebrain (MBF) or sham surgery. Twenty-four hours later the right kidney was vascularly isolated (but neurally intact) and perfused with an artificial plasma at either a constant pressure (100 mm Hg) or constant flow (600 microliters/min). Renal perfusate was collected before (pre-injection) and at 10 min intervals after central administration of peptides for determination of NESR and RSR. In both perfusion models, intracerebroventricular (ICV) ANG-II increased renal NESR. In MBF lesioned rats pre-injection renal NESR is reduced and the response to ICV ANG-II is blocked. In both perfusion models ICV ANG-II decreases renal RSR. Concomitant administration of SAR blocks the effect of ANG-II on both NESR and RSR. MBF lesioned rats had significantly elevated pre-injection levels of RSR and there is no change in RSR following ICV ANG-II. These experiments indicate that centrally administered ANG-II increases renal NESR concomitant with a decrease in renal RSR and that MBF lesions block those changes.
Weekley
L B
LB
Dept. of Veterinary Biosciences, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg 24061.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D005260:Female; D007276:Injections, Intraventricular; D007668:Kidney / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D016548:Prosencephalon / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012083:Renin / Q000378:metabolism*; D012504:Saralasin / Q000494:pharmacology; D000092502:Renin Inhibitors
D000804:Angiotensin II; D009638:Norepinephrine; D012083:Renin; D012504:Saralasin; D000092502:Renin Inhibitors