[Study on significance of lymphocyte chemiluminescence measurements in cancer patients].
Chemiluminescent responses of peripheral blood lymphocytes were measured in patients with carcinomas and healthy donors. The intensity of lymphocyte chemiluminescence (Ly-CL) in 54 preoperative patients was significantly lower than that in 97 healthy donors (P less than 0.05). Compared to that before treatment, the Ly-CL intensity in 14 patients after radiotherapy was decreased (P less than 0.05). However, Ly-CL intensity in 12 patients after 6-8 days of thymosin therapy was significantly increased (P less than 0.05), and exceeded that of healthy donors (P less than 0.01). These data suggest that Ly-CL measurements may become a new method for monitoring lymphocyte activity or function, and evaluating therapeutic effectiveness in cancer patients.
Zhang
X J
XJ
Anhui Medical University, Hefei.
D000328:Adult; D000368:Aged; D004067:Digestive System Neoplasms / Q000473:pathology; D005260:Female; D006801:Humans; D007167:Immunotherapy; D008163:Luminescent Measurements; D008175:Lung Neoplasms / Q000473:pathology / Q000628:therapy; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000378:metabolism*; D008875:Middle Aged; D009369:Neoplasms / Q000473:pathology* / Q000628:therapy; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000532:radiotherapy