A 35 kDa Fos-related antigen is co-localized with substance P and dynorphin in striatal neurons.
The rat striatum after dopamine denervation followed by repeated apomorphine treatment was examined for the co-expression of c-fos and Fos-related antigens with dynorphin, substance P and [Met5]enkephalin using Western blot and immunohistochemical techniques. Administration of apomorphine, a dopamine agonist, elevated the level of 35 kDa Fos-related antigen which co-localized with dynorphin and substance P, but not enkephalin, in striatal neurons.
Zhang
W Q
WQ
Laboratory of Molecular and Integrative Neuroscience, National Institute of Environmental Health Sciences, National Institute of Health Research Triangle Park, NC 27709.
Pennypacker
K R
KR
Ye
H
H
Merchenthaler
I J
IJ
Grimes
L
L
Iadarola
M J
MJ
Hong
J S
JS
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D015153:Blotting, Western; D003342:Corpus Striatum / Q000737:chemistry / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D004298:Dopamine / Q000502:physiology; D004399:Dynorphins / Q000032:analysis*; D016762:Genes, fos / Q000187:drug effects; D007150:Immunohistochemistry; D008297:Male; D008970:Molecular Weight; D009474:Neurons / Q000737:chemistry / Q000276:immunology*; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000032:analysis*; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology*
D016760:Proto-Oncogene Proteins c-fos; D013373:Substance P; D004399:Dynorphins; D001058:Apomorphine; D004298:Dopamine