Immunomodulatory effects of gamma-HCH (Lindane) in mice.
Mice were fed for 24 weeks with three different subtoxic dosages of gamma-HCH (0.012, 0.12 and 1.2 mg/kg) mixed in powdered feed. The immunological profile was assessed at an interval of one month during the entire exposure period. Both the cell mediated and humoral components of immunity showed a biphasic response characterized initially by stimulation followed by suppression in a dose dependent manner. However, gamma-HCH did not affect the functional properties of peritoneal macrophages. Histological changes in lymphoid organs were in accordance with the biphasic immunomodulatory effects of gamma-HCH.
Meera
P
P
Department of Zoology, Osmania University, Hyderabad, India.
Rao
P R
PR
Shanker
R
R
Tripathi
O
O
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D005260:Female; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D006968:Hypersensitivity, Delayed; D007107:Immune System / Q000187:drug effects*; D008213:Lymphocyte Activation / Q000187:drug effects; D007959:Lymphocyte Culture Test, Mixed; D008221:Lymphoid Tissue / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C
D001556:Hexachlorocyclohexane