Case report: role of granulocyte colony stimulating factor in radiotherapy.
Two patients who received granulocyte colony stimulating factor (G-CSF) before or during radiotherapy are reviewed. Both patients developed granulocytopenia after multi-agent chemotherapy. One patient had breast cancer with multiple distant metastasis and received palliative radiotherapy to the spine and hip joint. The other patient had locally advanced anal carcinoma and received concurrent 5-fluorouracil, mitomycin, and radiation therapy. Both patients completed the planned course of radiotherapy without interruption, after administration of G-CSF.
Zachariah
B
B
Department of Radiation Oncology, H. Lee Moffitt Cancer Center, University of South Florida, Tampa.
D000230:Adenocarcinoma / Q000097:blood / Q000532:radiotherapy / Q000628:therapy*; D000380:Agranulocytosis / Q000209:etiology / Q000517:prevention & control*; D000971:Antineoplastic Combined Chemotherapy Protocols; D001005:Anus Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D001943:Breast Neoplasms / Q000097:blood / Q000532:radiotherapy / Q000628:therapy*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D010315:Particle Accelerators; D011878:Radiotherapy / Q000009:adverse effects*
D016179:Granulocyte Colony-Stimulating Factor