title: Colony stimulating factor-1 stimulates Ishikawa cell proliferation and lipocortin II synthesis.
abstract: Proliferation of the Ishikawa human endometrial adenocarcinoma cell line is under the concerted control of oestrogen and progesterone. Here we demonstrate that Ishikawa cells express colony stimulating factor-1 (CSF-1), CSF-1 receptor mRNA and are growth stimulated by CSF-1 treatment. An early event associated with CSF-1 treatment is the induction of lipocortin II synthesis, a protein whose expression is also under oestrogen and progesterone control. However, neither CSF-1 or CSF-1 receptor mRNA appear to be modulated by oestrogen or progesterone.
authors.affiliation: Institute of Obstetrics and Gynaecology, Royal Postgraduate Medical School, Hammersmith Hospital, London, England.
authors.forename: J D
authors.initials: JD
authors.lastname: Croxtall
authors.forename: J W
authors.initials: JW
authors.lastname: Pollard
authors.forename: F
authors.initials: F
authors.lastname: Carey
authors.forename: R A
authors.initials: RA
authors.lastname: Forder
authors.forename: J O
authors.initials: JO
authors.lastname: White
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D017302:Annexins; D001483:Base Sequence; D002135:Calcium-Binding Proteins / Q000096:biosynthesis*; D002455:Cell Division / Q000187:drug effects*; D004591:Electrophoresis, Polyacrylamide Gel; D016889:Endometrial Neoplasms / Q000378:metabolism* / Q000473:pathology; D004967:Estrogens / Q000502:physiology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016173:Macrophage Colony-Stimulating Factor / Q000494:pharmacology*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011233:Precipitin Tests; D011374:Progesterone / Q000502:physiology; D012333:RNA, Messenger / Q000096:biosynthesis; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000235:genetics; D014407:Tumor Cells, Cultured
chemical_list: D017302:Annexins; D002135:Calcium-Binding Proteins; D004967:Estrogens; D012333:RNA, Messenger; D011374:Progesterone; D016173:Macrophage Colony-Stimulating Factor; D016186:Receptor, Macrophage Colony-Stimulating Factor; D012194:RNA-Directed DNA Polymerase