title: Allorecognition by NK cells: nonself or no self?
abstract: The issue of antigen recognition by NK cells is complex, fascinating and, as yet, unresolved. This article reviews recent research on the repertoire of human NK cell clones for the recognition of different allogeneic cells, and summarizes the studies, most of which have been performed in mice, that implicate the MHC in NK cell recognition. It goes on to provide a common conceptual framework within which these different systems may be understood.
authors.affiliation: Dip. di Medicina ed Oncologia Sperimentale, University of Turin, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Moretta
authors.forename: E
authors.initials: E
authors.lastname: Ciccone
authors.forename: A
authors.initials: A
authors.lastname: Moretta
authors.forename: P
authors.initials: P
authors.lastname: Höglund
authors.forename: C
authors.initials: C
authors.lastname: Ohlén
authors.forename: K
authors.initials: K
authors.lastname: Kärre
mesh_terms: D000818:Animals; D002999:Clone Cells; D003602:Cytotoxicity, Immunologic; D000939:Epitopes / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006801:Humans; D016130:Immunophenotyping; D007519:Isoantigens / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation
chemical_list: D000939:Epitopes; D015395:Histocompatibility Antigens Class I; D007519:Isoantigens