title: High prevalence of Clostridium difficile diarrhoea during intensive chemotherapy for disseminated germ cell cancer.
abstract: A prospective, consecutive study of the aetiology of treatment-associated diarrhoea was conducted in 25 patients with disseminated germ cell cancer treated with intensive chemotherapy. Clostridium difficile was isolated in 45% of the diarrhoea episodes, which makes this species the most important bacterial pathogen in the development of clinically significant diarrhoea in this group of immunocompromised patients.
authors.affiliation: Department of Clinical Microbiology, Rigshopitalet, Copenhagen, Denmark.
authors.forename: H
authors.initials: H
authors.lastname: Nielsen
authors.forename: G
authors.initials: G
authors.lastname: Daugaard
authors.forename: M
authors.initials: M
authors.lastname: Tvede
authors.forename: B
authors.initials: B
authors.lastname: Bruun
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D016360:Clostridioides difficile / Q000302:isolation & purification*; D003967:Diarrhea / Q000188:drug therapy / Q000382:microbiology*; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D016867:Immunocompromised Host; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy*; D015995:Prevalence; D011446:Prospective Studies
chemical_list: D001761:Bleomycin; D005047:Etoposide; D002945:Cisplatin