Effects of interleukin-1 receptor antagonist on the behavioral effects of lipopolysaccharide in rat.
To investigate the role of interleukin-1 (IL-1) in lipopolysaccharide (LPS)-induced sickness behavior, rats were injected with recombinant human interleukin-1 receptor antagonist (IL-1ra), an endogenous cytokine able to block most of the biological effects of IL-1 both in vivo and in vitro. Intraperitoneal injection of IL-1ra (3 mg/rat) attenuated the depressive effect of LPS (250 micrograms/kg) on social exploration and body weight when both treatments were injected peripherally. Intracerebroventricular injection of IL-1ra (60 micrograms/rat) did not block the effects of peripherally injected LPS. These data indicate that the peripherally mediated effects of IL-1 account for a significant part of LPS-induced sickness behavior.
Bluthé
R M
RM
INRA-INSERM U176, Bordeaux, France.
Dantzer
R
R
Kelley
K W
KW
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D005106:Exploratory Behavior / Q000187:drug effects*; D007276:Injections, Intraventricular; D007378:Interleukins / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology; D008070:Lipopolysaccharides / Q000633:toxicity*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011971:Receptors, Immunologic / Q000037:antagonists & inhibitors*; D017472:Receptors, Interleukin-1; D012016:Reference Values
D007378:Interleukins; D008070:Lipopolysaccharides; D011971:Receptors, Immunologic; D017472:Receptors, Interleukin-1