An 'anatomical cascade hypothesis' for Alzheimer's disease.
The molecular mechanisms of the cytopathology of Alzheimer's disease are very rapidly being elucidated. However, the factors that restrict the effects of this disease to specific neuroanatomical systems are less well understood. In this brief article a possible hypothesis is outlined to explain this apparent specific localization.
Hardy
J
J
Dept of Biochemistry and Molecular Genetics, St Mary's Hospital Medical School, London, UK.
D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D006801:Humans; D009928:Organ Specificity
D016229:Amyloid beta-Peptides