title: Minor neurological dysfunction from birth to 12 years. I: Increase during late school-age.
abstract: To study the hypothesis that the frequency of minor neurological dysfunction (MND) stabilizes around the age of nine years, two groups of the Groningen Perinatal Project (GPP) were re-examined at 12 years. The study group (N = 174) was selected on the basis of the presence of MND at nine years; the control group comprised 172 neurologically normal children. The hypothesis was rejected: extrapolation of the findings to the total GPP population showed that the over-all rate of MND increased. Control children who developed MND were mainly boys who had been neurologically abnormal at birth or were born preterm and/or had experienced an adversity in combination with asphyxia. Interval complications between nine and 12 years were related to the emergence of MND.
authors.affiliation: Department of Developmental Neurology, University Hospital Groningen, The Netherlands.
authors.forename: R J
authors.initials: RJ
authors.lastname: Lunsing
authors.forename: M
authors.initials: M
authors.lastname: Hadders-Algra
authors.forename: H J
authors.initials: HJ
authors.lastname: Huisjes
authors.forename: B C
authors.initials: BC
authors.lastname: Touwen
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D002648:Child; D002653:Child Behavior Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D002658:Developmental Disabilities / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D009460:Neurologic Examination; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology