[Study of the possibility to abolish the action of immunosuppressive factors of tumor cells].
We investigated the efficacy of IL-2, LPS, MDP, TRA, ionomycin and contrykal on proliferation of lymphocytes treated by tumor cell immunosuppressive factors (ISF). IL-2, LPS and/or MDP did not abolish the influence of P815 and B16 ISF on Con A or alloantigen-induced lymphocyte proliferation. TPA and in less extent ionomycin and combination of the above preparations totally abrogated the suppression of Con A-induced lymphocyte proliferation. In inverted experiments Con A abrogated ISF-mediated suppression of lymphocyte proliferation induced by TPA plus ionomycin.
Fuks
B B
BB
Klaamas
K V
KV
Rakhmilevich
A L
AL
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology; D000818:Animals; D007611:Aprotinin / Q000494:pharmacology; D003208:Concanavalin A / Q000494:pharmacology; D007108:Immune Tolerance; D007376:Interleukin-2 / Q000494:pharmacology; D015759:Ionomycin / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D012515:Mast-Cell Sarcoma / Q000276:immunology*; D008546:Melanoma, Experimental / Q000276:immunology*; D051379:Mice; D012513:Sarcoma, Experimental / Q000276:immunology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000276:immunology
D007376:Interleukin-2; D008070:Lipopolysaccharides; D003208:Concanavalin A; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D015759:Ionomycin; D007611:Aprotinin; D013755:Tetradecanoylphorbol Acetate