title: Interleukin 6 activity in pleural effusion. Its diagnostic value and thrombopoietic activity.
abstract: We measured interleukin 6 (IL-6) concentrations in the pleural fluid of various patients to determine its role in pathophysiology and diagnosis by using specific functional bioassay. IL-6 levels were significantly higher in exudate than in transudate (79.3 +/- 176.2 U/ml [n = 55] vs 1.7 +/- 1.8 U/ml [n = 12]; p < 0.01). Tuberculous effusion contained a significantly higher amount of IL-6 than malignant effusion (181.3 +/- 176.2 U/ml [n = 13] vs 29.4 +/- 71.5 U/ml [n = 29]; p < 0.005). Pleural IL-6 levels were invariably higher than serum IL-6 levels, and both were significantly correlated (n = 21, r = 0.632; p < 0.02). Pleural IL-6 levels were significantly correlated with lactate dehydrogenase (LDH) in pleural fluid (r = 0.392; p < 0.01), ratio of pleural/serum LDH (r = 0.571; p < 0.01), pleural adenosine deaminase activity (r = 0.599; p < 0.01), and serum C-reactive protein (r = 0.494; p < 0.01). Furthermore, IL-6 levels were significantly correlated with peripheral blood platelet counts (r = 0.447; p < 0.001). These results suggest that (1) IL-6 is produced locally in pleural space, (2) pleural IL-6 level is helpful for differential diagnosis, and (3) locally produced IL-6 could leak to circulation and cause systemic effects such as the induction of C-reactive protein and thrombocytosis.
authors.affiliation: Second Department of Internal Medicine, Ehime University School of Medicine, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Yokoyama
authors.forename: M
authors.initials: M
authors.lastname: Maruyama
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: N
authors.initials: N
authors.lastname: Kohno
authors.forename: K
authors.initials: K
authors.lastname: Hiwada
authors.forename: S
authors.initials: S
authors.lastname: Yano
mesh_terms: D000243:Adenosine Deaminase / Q000032:analysis; D016724:Empyema, Pleural / Q000150:complications / Q000175:diagnosis; D005122:Exudates and Transudates / Q000737:chemistry*; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis* / Q000502:physiology; D008175:Lung Neoplasms / Q000150:complications; D010976:Platelet Count; D010996:Pleural Effusion / Q000097:blood / Q000209:etiology* / Q000378:metabolism*; D016066:Pleural Effusion, Malignant / Q000175:diagnosis / Q000378:metabolism; D014396:Tuberculosis, Pleural / Q000150:complications / Q000175:diagnosis
chemical_list: D015850:Interleukin-6; D000243:Adenosine Deaminase