title: Comparison of atracurium-induced neuromuscular block in rectus abdominis and hand muscles of man.
abstract: We have compared neuromuscular block in the rectus abdominis and the hand muscles in 11 adult patients. Atracurium 0.5 mg kg-1 was administered by single bolus and anaesthesia maintained with isoflurane and nitrous oxide in oxygen. Train-of-four (TOF) stimulation was applied to the 10th intercostal space in the anterior axillary line and to the ulnar nerve at the wrist. Electromyographic (EMG) responses were recorded over the rectus abdominis and hypothenar muscles. Neuromuscular block had a significantly faster onset in the rectus abdominis (mean 1.6 (SEM 0.2) min) than in the hand (2.4 (0.3) min) (P less than 0.001). Recovery occurred more rapidly in the rectus abdominis: time to 25% TOF recovery was 39 (3) min at rectus abdominis and 51 (4) min at the hand (P less than 0.001). Time to 75% TOF recovery was 56 (4) min at rectus abdominis and 72 (6) min at the hand (P less than 0.001).
authors.affiliation: Shackleton Department of Anaesthetics, Southampton General Hospital.
authors.forename: J M
authors.initials: JM
authors.lastname: Saddler
authors.forename: L F
authors.initials: LF
authors.lastname: Marks
authors.forename: J
authors.initials: J
authors.lastname: Norman
mesh_terms: D000009:Abdominal Muscles / Q000187:drug effects*; D000328:Adult; D001279:Atracurium / Q000494:pharmacology*; D004576:Electromyography; D006225:Hand; D006801:Humans; D008875:Middle Aged; D009469:Neuromuscular Junction / Q000187:drug effects*; D013997:Time Factors
chemical_list: D001279:Atracurium