title: The cell adhesion molecule L1 has a specific role in neural cell migration.
abstract: L1-transfected L cells show a markedly enhanced ability for neuronal cell binding and promotion of neuron migration compared with control L cells. Further, when purified L1 was used as a culture substrate for neurons, it was found to promote neuronal adhesion and enhance the speed of migration of cerebellar neurons from reaggregated cultures, indicating that it is involved in a determinant step of neural cell migration.
authors.affiliation: Department of Physiology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Asou
authors.forename: M
authors.initials: M
authors.lastname: Miura
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
authors.forename: K
authors.initials: K
authors.lastname: Uyemura
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D002478:Cells, Cultured; D002531:Cerebellum / Q000502:physiology*; D003001:Cloning, Molecular; D005455:Fluorescent Antibody Technique; D039841:Leukocyte L1 Antigen Complex; D051379:Mice; D009474:Neurons / Q000502:physiology*; D051381:Rats; D014162:Transfection
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D039841:Leukocyte L1 Antigen Complex