title: Brain factor from Galleria mellonella (Lepidoptera) stimulating silk gland activity.
abstract: Brain extracts from day 1-4 last instar larvae of Galleria mellonella (Lepidoptera) stimulate RNA synthesis in cultured silk glands from day 3 last instar larvae. When the fibroin-synthesizing posterior parts of silk glands were incubated for 3 h in vitro in the presence of brain extract (0.1 brain equivalent), [3H]-uridine incorporation into RNA was stimulated more than twofold. The stimulating effect of brain extract showed a dose response relationship. It is suggested that the heat-resistant and protease-sensitive brain factor is a peptide.
authors.affiliation: Department of Comparative Biochemistry, Polish Academy of Sciences, Warsaw.
authors.forename: J
authors.initials: J
authors.lastname: Michalik
authors.forename: E
authors.initials: E
authors.lastname: Szolajska
authors.forename: Z
authors.initials: Z
authors.lastname: Lassota
mesh_terms: D000818:Animals; D007301:Insect Hormones / Q000737:chemistry / Q000502:physiology*; D019476:Insect Proteins; D009036:Moths / Q000502:physiology*; D009490:Neurosecretory Systems / Q000502:physiology*; D011506:Proteins / Q000378:metabolism*; D012313:RNA / Q000378:metabolism; D047011:Silk; D014020:Tissue Extracts
chemical_list: D007301:Insect Hormones; D019476:Insect Proteins; D011506:Proteins; D047011:Silk; D014020:Tissue Extracts; D012313:RNA