Long-term effects of imipramine on striatal dopamine autoreceptor function: involvement of both noradrenergic and serotonergic systems.
1. The effects of apomorphine (APO) administration on DA system activity were assessed by measuring dopamine metabolite levels (HVA) in several circumstances. 2. Pretreatment with IMI reduced the effect of APO on HVA levels. 3. Pretreatments with either IDE or DMI did not reduce the effect of APO on HVA levels. 4. Reductions of either NE and 5-HT levels after DSP4 and pCPA restored the effect of APO after IMI pretreatment.
Scavone
C
C
Departamento de Farmacologia, Universidade de São Paulo, Brazil.
Aizenstein
M L
ML
Planeta
C da S
Cda S
De Lucia
R
R
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001596:Benzylamines / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D010134:Fenclonine / Q000494:pharmacology; D006719:Homovanillic Acid / Q000378:metabolism; D007099:Imipramine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000378:metabolism / Q000502:physiology*; D010880:Piperidines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D012701:Serotonin / Q000378:metabolism / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology
D001596:Benzylamines; D010880:Piperidines; D011954:Receptors, Dopamine; D012702:Serotonin Antagonists; D012701:Serotonin; D001058:Apomorphine; D007099:Imipramine; C012102:DSP 4; D010134:Fenclonine; C018181:indalpine; D009638:Norepinephrine; D006719:Homovanillic Acid