[Changes in the parameters of respiratory mechanics after the aspiration reflex and asphyxia].
Parameters of respiration mechanics (dynamic compliance--Cdyn and total lung resistance--RL), ventilation, blood gases, and right-to-left pulmonary shunts were studied after aspiration reflex in experiments on 29 anesthetized cats. Attacks of aspiration reflex were induced without asphyxia (8 cats) and during two-minute asphyxia (9 cats). The control group consisted of 12 animals. A series of aspiration reflex attacks resulted in short-term improvement of the parameters of respiration mechanics with an increase in Cdyn and reduction of RL. A simultaneous elevation of PaO2 and a decrease of PaCO2 were recorded. In combination with asphyxia (hypoxemia and hyperkapnia), the aspiration reflex induced a reversed reaction, i.e. decreased Cdyn lasting till the end of experiment (3 hours) and an increase of functional alveolar right-to-left shunts. The results indicate that in cats impairment of respiration mechanics parameters is brought on only when deep inspiration is combined with asphyxia.
Javorka
K
K
Ustav fyziológie Jeseniovej lekárskej fakulty Univerzity Komenského, Martin, CSFR.
Petrásková
M
M
Zelenayová
E
E
D000403:Airway Resistance; D000818:Animals; D001237:Asphyxia / Q000097:blood / Q000503:physiopathology*; D002245:Carbon Dioxide / Q000097:blood; D002415:Cats; D001239:Inhalation / Q000502:physiology*; D008170:Lung Compliance; D010100:Oxygen / Q000097:blood; D011652:Pulmonary Circulation; D012018:Reflex; D015656:Respiratory Mechanics
D002245:Carbon Dioxide; D010100:Oxygen