title: The genotoxicity of chromium(VI) oxide in the wing spot test of Drosophila melanogaster is over 90% due to mitotic recombination.
abstract: Chromium(VI) oxide and chromium(III) chloride were tested in the wing somatic mutation and recombination test (SMART) in Drosophila melanogaster according to standard procedures. The hexavalent compound was highly genotoxic in both chronic and acute treatments whereas the trivalent one was clearly negative. Further analysis of wings carrying an inversion chromosome which eliminates all recombination events showed that over 90% of the spots induced by chromium(VI) oxide are due to mitotic recombination.
authors.affiliation: Institute of Toxicology, Swiss Federal Institute of Technology, Schwerzenbach.
authors.forename: U
authors.initials: U
authors.lastname: Graf
authors.forename: O S
authors.initials: OS
authors.lastname: Heo
authors.forename: O O
authors.initials: OO
authors.lastname: Ramirez
mesh_terms: D000818:Animals; D002712:Chlorides; D002857:Chromium / Q000633:toxicity*; D017608:Chromium Compounds; D004331:Drosophila melanogaster; D008938:Mitosis / Q000187:drug effects*; D009154:Mutation; D011995:Recombination, Genetic
chemical_list: D002712:Chlorides; D017608:Chromium Compounds; D002857:Chromium; C017133:chromous chloride; C023600:chromic oxide