title: Acetylation status using hydralazine in African hypertensives at Kenyatta National Hospital.
abstract: In this study, the investigation of hydralazine acetylator phenotype was undertaken for the first time in African hypertensives at Kenyatta National Hospital. A total of 25 randomly selected patients with moderate to severe hypertension (diastolic pressure 105-130 mmHg), participated in the phenotyping study. The phenotyping was done by administering oral standard hydralazine dose of 150 mg/day in three divided doses. The 24 hour urinary MTP/hydralazine ratio was used to categorize patients into slow and fast acetylators. Of the patients studied 69.9% were slow acetylators while 30.4% were fast acetylators. The mean 24 hour urinary MTP/hydralazine ratio for slow acetylators was 1.01 +/- 0.95. This was significantly different from the fast acetylators where the mean 24 hour urinary MTP/hydralazine ratio was 10.6 +/- 4.4 (P < 0.001). The acetylator phenotyping divided the patients into two distinct populations and no further arbitrary method was required to divide the patients into either group.
authors.affiliation: Clinical Research Centre, Nairobi.
authors.forename: J R
authors.initials: JR
authors.lastname: Rashid
authors.lastname: Kofi-Tsepko
authors.forename: F D
authors.initials: FD
authors.lastname: Juma
mesh_terms: D000107:Acetylation; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001191:Arylamine N-Acetyltransferase; D005260:Female; D005787:Gene Frequency; D006779:Hospitals, Public; D006801:Humans; D006830:Hydralazine / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D006973:Hypertension / Q000188:drug therapy* / Q000453:epidemiology / Q000235:genetics; D007630:Kenya / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010641:Phenotype
chemical_list: D006830:Hydralazine; D001191:Arylamine N-Acetyltransferase