title: Efficacy of a sustained-release device containing chlorhexidine and Ca(OH)2 in preventing secondary infection of dentinal tubules.
abstract: This study was conducted to evaluate the efficacy of the antibacterial activity of Ca(OH)2 and a sustained-release device containing chlorhexidine (SRD) in both sterilization and prevention of secondary infection of the root canal system. Bovine root dentine specimens previously incubated with Streptococcus faecalis were used in this experiment. Two different formulations of the SRD (differing in their cross-linkage), Ca(OH)2 and normal saline (control) were evaluated. The degree of bacterial infection of the root canal was tested after incubation periods of 24 h, 72 h and 7 days with these medicaments. Their efficacy in preventing secondary infection after recontamination was tested after 72 h and 7 days. The results demonstrated that both formulations of the SRD significantly reduced the bacterial population in the primary infected groups, as well as preventing secondary infection of the dentinal tubules in the recontaminated group. By contrast, Ca(OH)2 did not show any antibacterial activity, and failed to sterilize the dentinal tubules or prevent secondary infection after recontamination at the time periods examined.
authors.affiliation: Hadassah-Hebrew University, Jerusalem.
authors.forename: I
authors.initials: I
authors.lastname: Heling
authors.forename: D
authors.initials: D
authors.lastname: Steinberg
authors.forename: S
authors.initials: S
authors.lastname: Kenig
authors.forename: I
authors.initials: I
authors.lastname: Gavrilovich
authors.forename: M N
authors.initials: MN
authors.lastname: Sela
authors.forename: M
authors.initials: M
authors.lastname: Friedman
mesh_terms: D000818:Animals; D002126:Calcium Hydroxide / Q000008:administration & dosage* / Q000494:pharmacology; D002417:Cattle; D002710:Chlorhexidine / Q000008:administration & dosage* / Q000494:pharmacology; D015169:Colony Count, Microbial; D003692:Delayed-Action Preparations; D003804:Dentin / Q000382:microbiology*; D013293:Enterococcus faecalis / Q000187:drug effects; D016908:Gram-Positive Bacterial Infections / Q000517:prevention & control*; D012388:Root Canal Irrigants / Q000008:administration & dosage*; D013242:Sterilization
chemical_list: D003692:Delayed-Action Preparations; D012388:Root Canal Irrigants; D002126:Calcium Hydroxide; D002710:Chlorhexidine