title: Neurodevelopmental outcome in very-low-birth-weight infants with or without periventricular haemorrhage and/or leucomalacia.
abstract: The aim of the study was to verify the predictive value of ultrasound performed in the neonatal period for short-term neurodevelopmental prognosis in 122 preterm very-low-birth-weight infants followed-up at 36 months. Neuromotor development was favourable in 53 (87%) subjects with normal ultrasound findings and in 21 (81%) subjects presenting uncomplicated haemorrhage. However, sensory and/or cognitive sequelae developed in 13% and 19% of the two groups, respectively. Outcome was unfavourable in 14 (50%) of 28 patients with ultrasound findings of complicated cerebral haemorrhages and in 5 (71%) of those (7) with ultrasound findings of parenchymal lesions without haemorrhage. Neonatal ultrasound examination seems to be fundamental in predicting neuromotor, but not cognitive, outcome in very-low-birth-weight infants.
authors.affiliation: Department of Child Neuropsychiatry, IRCCS C. Mondino Foundation, University of Pavia, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Fazzi
authors.forename: G
authors.initials: G
authors.lastname: Lanzi
authors.forename: A
authors.initials: A
authors.lastname: Gerardo
authors.forename: A
authors.initials: A
authors.lastname: Ometto
authors.forename: S
authors.initials: S
authors.lastname: Orcesi
authors.forename: G
authors.initials: G
authors.lastname: Rondini
mesh_terms: D002543:Cerebral Hemorrhage / Q000145:classification / Q000150:complications / Q000000981:diagnostic imaging*; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007558:Italy / Q000453:epidemiology; D007969:Leukomalacia, Periventricular / Q000145:classification / Q000150:complications / Q000000981:diagnostic imaging*; D008297:Male; D011379:Prognosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D014463:Ultrasonography