Inhibitory effects of azelastine on nasal allergic responses in sensitized guinea pigs.
The in vivo effects of the antiallergic drug azelastine were investigated in sensitized guinea pigs. Topical administration of antigen into the nasal cavity produced an increase in nasal vascular permeability together with an increase in both the histamine and leukotriene C4 (LTC4) concentrations of nasal lavage fluid. Pre-treatment with azelastine significantly inhibited both the LTC4 release and the increase in nasal vascular permeability. These results suggest that azelastine inhibits the release of antigen-induced leukotrienes and increases nasal vascular permeability in vivo.
Shirasaki
H
H
Department of Otolaryngology, Sapporo Medical College, Japan.
Asakura
K
K
Sohma
S
S
Kataura
A
A
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects; D007114:Immunization; D008297:Male; D010047:Ovalbumin / Q000276:immunology; D010793:Phthalazines / Q000494:pharmacology*; D012221:Rhinitis, Allergic, Perennial / Q000503:physiopathology*; D013189:SRS-A / Q000378:metabolism
D006634:Histamine H1 Antagonists; D010793:Phthalazines; D013189:SRS-A; D010047:Ovalbumin; C020976:azelastine