title: Studies of Org 10172 in patients with acute ischemic stroke. TOAST Study Group.
abstract: This report presents data from pilot studies of Org 10172 in the management of patients with acute ischemic stroke. The studies have established a potentially optimal dosage and treatment regimen and have provided information for the development of a large randomized trial. The trial of Org 10172 in acute stroke treatment is now underway in the United States.
authors.affiliation: Department of Neurology, University of Iowa College of Medicine, Iowa City 52242.
authors.forename: H P
authors.initials: HP
authors.lastname: Adams
authors.forename: R F
authors.initials: RF
authors.lastname: Woolson
authors.forename: J
authors.initials: J
authors.lastname: Biller
authors.forename: W
authors.initials: W
authors.lastname: Clarke
mesh_terms: D002545:Brain Ischemia / Q000188:drug therapy* / Q000453:epidemiology; D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D004341:Drug Evaluation; D065427:Factor Xa Inhibitors; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006025:Glycosaminoglycans / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006470:Hemorrhage / Q000139:chemically induced; D006496:Heparinoids / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006497:Heparan Sulfate; D006801:Humans; D015994:Incidence; D010865:Pilot Projects; D011516:Prothrombin / Q000037:antagonists & inhibitors; D015912:Thrombolytic Therapy; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology
chemical_list: D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D065427:Factor Xa Inhibitors; D005343:Fibrinolytic Agents; D006025:Glycosaminoglycans; D006496:Heparinoids; D006497:Heparan Sulfate; D011516:Prothrombin; C025337:Factor IIa; C035838:danaparoid