Pentafraction reduces the lung lymph response after endotoxin administration in the ovine model.
For the past half-century, several high molecular weight compounds have been used for volume expansion during cardiopulmonary resuscitation. However, the effectiveness and side effects of these different expanders are varied. We have compared plasma, pentastarch, and a new product, pentafraction, for effective plasma volume expansion before and after tissue injury with endotoxin administration. In each group, eight range ewes instrumented with a Swan-Ganz, arterial, and venous catheters, and lung and flank lymphatic cannulas were compared. Each group received 15 ml/kg of either 6% pentafraction, 6% pentastarch, or plasma followed two hours later by 1.5 micrograms/kg/0.5 hr E. Coli endotoxin over 30 min. Data were collected for an additional 24 hr after endotoxin administration. Our results indicated a plasma volume expansion in all three groups. However, the prior administration of pentafraction significantly attenuated the increase in the lung lymph flow and early evaluation of systemic vascular resistance noted with endotoxin in comparison to the other two groups.
Traber
L D
LD
University of Texas Medical Branch, Galveston.
Brazeal
B A
BA
Schmitz
M
M
Toole
J
J
Coffey
J
J
Flynn
J T
JT
Traber
D L
DL
D015121:6-Ketoprostaglandin F1 alpha / Q000032:analysis; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002199:Capillary Permeability / Q000187:drug effects; D004195:Disease Models, Animal; D006895:Hydroxyethyl Starch Derivatives / Q000494:pharmacology / Q000627:therapeutic use*; D008196:Lymph / Q000378:metabolism*; D008970:Molecular Weight; D011654:Pulmonary Edema / Q000188:drug therapy*; D012756:Sheep; D012772:Shock, Septic / Q000188:drug therapy*; D013929:Thromboxane B2 / Q000032:analysis
D006895:Hydroxyethyl Starch Derivatives; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha