Tumor associated glycoprotein-72 (TAG-72) levels in patients with non-malignant and malignant disease.
TAG-72 is a tumor-associated antigen identified by the monoclonal antibody B72.3. Serum levels of TAG-72 were measured in patients with non-malignant and malignant disease. TAG-72 is not a specific marker of cancer and slightly elevated levels of this antigen can also be detected in the serum of healthy subjects. However, our results show that specificity (92%) and positive predictive value (86%) of this marker are very high. TAG-72 levels above the cut-off limit of 6 U/mL were found in patients with tumors of various organs, including gastrointestinal, ovarian, lung and breast cancer. TAG-72 assay sensitivity is related to tumor stage with values being highest with advanced disease, especially in patients with gastric cancer and lung adenocarcinoma.
Filella
X
X
Department of Clinical Biochemistry (Unit for Cancer Research). Hospital Clínic i Provincial, Barcelona, Spain.
Molina
R
R
Jo
J
J
Bedini
J L
JL
Joseph
J
J
Ballesta
A M
AM
D000951:Antigens, Neoplasm / Q000032:analysis*; D005260:Female; D006023:Glycoproteins / Q000032:analysis*; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D009369:Neoplasms / Q000097:blood* / Q000473:pathology; D011237:Predictive Value of Tests; D011247:Pregnancy; D012680:Sensitivity and Specificity
D000951:Antigens, Neoplasm; D006023:Glycoproteins; C047052:tumor-associated antigen 72