title: Radiation-induced osteosarcoma of the calvaria--case report.
abstract: The authors report a case of radiation-induced calvarial osteosarcoma. A 58-year-old female received subtotal removal of the pituitary adenoma and 5000 rads postoperative irradiation. Seven years later, an osteoblastic osteosarcoma occurred in the frontotemporal region. She received total tumor removal and chemotherapy. However, computed tomography subsequently revealed multiple small lesions at the margin of the bone flap. A chest x-ray film demonstrated lung metastasis. Local recurrence and lung metastasis require careful attention in radiation-induced osteosarcoma patients.
authors.affiliation: Department of Neurosurgery, Kurume University School of Medicine, Fukuoka.
authors.forename: Y
authors.initials: Y
authors.lastname: Sugita
authors.forename: M
authors.initials: M
authors.lastname: Shigemori
authors.forename: J
authors.initials: J
authors.lastname: Miyagi
authors.forename: S
authors.initials: S
authors.lastname: Ochiai
authors.forename: S
authors.initials: S
authors.lastname: Lee
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: H
authors.initials: H
authors.lastname: Abe
authors.forename: M
authors.initials: M
authors.lastname: Morimatsu
mesh_terms: D000236:Adenoma / Q000150:complications / Q000532:radiotherapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000628:therapy; D012516:Osteosarcoma / Q000209:etiology* / Q000556:secondary / Q000628:therapy; D010911:Pituitary Neoplasms / Q000150:complications / Q000532:radiotherapy; D011878:Radiotherapy / Q000009:adverse effects*; D012888:Skull Neoplasms / Q000209:etiology* / Q000628:therapy