[Correlativity of plasma endotoxin, plasma fibronectin and common bile duct pressure in severe acute cholangitis].
On the basis of common bile duct pressure measurement (CBDP) in 18 patients of severe acute cholangitis, plasma endotoxin (ET) was determined by modified synthetic chromogenic limulus amebocyte lysate assay and plasma fibronectin (FN) was detected with Laurell's rocket immunoelectrophoresis. CBDP was 2.23 +/- 0.49 KPa in patient group. There was striking positive correlation between ET and CBDP. Preoperative ET was 202.73 +/- 88.57 ng/L in patient group which was much higher than 15.47 +/- 7.38 ng/L in the control (P less than 0.001). Preoperative FN was 141.77 +/- 82.37 mg/L in the patient group which was lower than 317.21 +/- 12.57 mg/L in the control (p less than 0.001). Statistical differences could be noticed in postoperative ET and FN between the survivor and the dead. The study suggested that plasma ET levels are greatly influenced by pressure gradient of bile duct, dynamic observations of ET and FN levels are helpful to monitor disease course and predict prognosis.
Zhang
L M
LM
Ningbo Second Hospital, Zhejiang.
D000208:Acute Disease; D000328:Adult; D000368:Aged; D002761:Cholangitis / Q000097:blood* / Q000503:physiopathology / Q000601:surgery; D003135:Common Bile Duct / Q000382:microbiology / Q000503:physiopathology*; D004731:Endotoxins / Q000097:blood*; D004926:Escherichia coli / Q000302:isolation & purification; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D007122:Immunoelectrophoresis; D008033:Limulus Test; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011312:Pressure; D011379:Prognosis
D004731:Endotoxins; D005353:Fibronectins