title: The contents of macromolecule solutes in flexor tendon sheath fluid and their relation to synovial fluid. A quantitative analysis.
abstract: The importance of synovial environment for minimal adhesion formation in flexor tendon healing has recently gained attention. Various techniques have been used to restore an injured synovial tendon sheath. Therefore a quantitative analysis of flexor tendon sheath fluid is of interest to increase our knowledge about the specific synovial milieu and to evaluate the success of different types of sheath reconstructions from a biochemical point of view. Samples of tendon sheath fluid from trigger digits and tendon sheaths containing ganglions have been assayed for contents of hyaluronic acid and proteins of different molecular weights. The results show concentrations of hyaluronate and several proteins similar to those in normal joint fluid. These results indicate that flexor tendon sheath fluid has a character similar to synovial fluid of joints and apparently has specific functions such as soft tissue lubrication and nutrition of avascular tendon tissue.
authors.affiliation: Department of Hand Surgery, Malmö Allmänna Sjukhus, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Hagberg
authors.forename: D
authors.initials: D
authors.lastname: Heinegård
authors.forename: K
authors.initials: K
authors.lastname: Ohlsson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000418:Albumins / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D005110:Extracellular Space / Q000737:chemistry*; D005260:Female; D005724:Ganglia / Q000378:metabolism; D006801:Humans; D006820:Hyaluronic Acid / Q000032:analysis* / Q000097:blood; D007074:Immunoglobulin G / Q000032:analysis; D019272:Leukocyte Elastase; D007962:Leukocytes / Q000201:enzymology; D046911:Macromolecular Substances; D008297:Male; D008875:Middle Aged; D010196:Pancreatic Elastase / Q000032:analysis / Q000097:blood; D053491:Proteinase Inhibitory Proteins, Secretory; D011506:Proteins / Q000032:analysis*; D015842:Serine Proteinase Inhibitors / Q000032:analysis / Q000097:blood; D012709:Serum Albumin / Q000032:analysis; D013582:Synovial Fluid / Q000737:chemistry*; D013710:Tendons / Q000294:innervation / Q000378:metabolism*; D000514:alpha 1-Antichymotrypsin / Q000032:analysis / Q000097:blood; D000515:alpha 1-Antitrypsin / Q000032:analysis; D000511:alpha-Macroglobulins / Q000032:analysis
chemical_list: D000418:Albumins; D001798:Blood Proteins; D007074:Immunoglobulin G; D046911:Macromolecular Substances; D053491:Proteinase Inhibitory Proteins, Secretory; D011506:Proteins; D015842:Serine Proteinase Inhibitors; D012709:Serum Albumin; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D006820:Hyaluronic Acid; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase