[Effects of administration of three kinds of catecholamine on mitral complex].
To evaluate cardiac injury induced by injection of 3 kinds of catecholamine, 219 male rabbits were examined. Eighty-five to 100 percent of the animals having high doses of adrenaline and noradrenaline showed ventricular premature contraction, and 65 to 75 percent of them showed mitral complex injury; whereas, these effects were identified in none or only in 10 percent of the animals with isoproterenol injection. The cardiac injury was similar to that of vagal stimulation, which was reported previously. These results indicate that ventricular premature contractions are important for developing the adrenaline- and noradrenaline-induced mitral complex injury.
Imataka
K
K
Institute for Adult Diseases, Asahi Life Foundation, Tokyo.
Sakamoto
H
H
Okamoto
E
E
Ieki
K
K
Fujii
J
J
D000818:Animals; D005117:Cardiac Complexes, Premature / Q000139:chemically induced; D002395:Catecholamines / Q000009:adverse effects*; D004837:Epinephrine / Q000009:adverse effects; D007545:Isoproterenol / Q000009:adverse effects; D008297:Male; D008943:Mitral Valve / Q000187:drug effects* / Q000473:pathology; D009638:Norepinephrine / Q000009:adverse effects; D011817:Rabbits
D002395:Catecholamines; D007545:Isoproterenol; D009638:Norepinephrine; D004837:Epinephrine