Assignment of the gene coding for the alpha 2-macroglobulin receptor to mouse chromosome 15 and to human chromosome 12q13-q14 by isotopic and nonisotopic in situ hybridization.
The assignment of the gene encoding the alpha 2-macroglobulin receptor (A2MR), which was first described as the low-density lipoprotein receptor-related protein, was confirmed by nonisotopic and isotopic in situ hybridizations on normal human metaphases to the region 12q13-q14. The same human cDNA, which has 95% sequence identity with the mouse A2mr, was hybridized to metaphases containing the Robertsonian translocation Rb(6;15)1Ald. The mouse A2mr gene was assigned to chromosome 15 in the region B2-D1. This locus and other loci on mouse chromosome 15 have been shown to be homologous with loci on human chromosome 12q.
Hilliker
C
C
Center for Human Genetics, University of Leuven, Belgium.
Van Leuven
F
F
Van den Berghe
H
H
D000818:Animals; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D005796:Genes; D005819:Genetic Markers; D006801:Humans; D051379:Mice / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D014178:Translocation, Genetic; D000511:alpha-Macroglobulins / Q000235:genetics*
D005819:Genetic Markers; D000511:alpha-Macroglobulins