title: Use of monitoring software to improve the measurement of carotid wall thickness by B-mode imaging.
abstract: METHODS
  High-resolution B-mode imaging is a reliable, easily performed and non-invasive means of studying atherosclerosis in superficial blood vessels. Recently it has been used for in vivo studies on the thickness of the common carotid artery wall. It is very sensitive, although the results of practical investigations are highly dependent on both the operator and the direction and angle of ultrasound beams directed towards the vessel.
  
  
  METHODS
  We have assessed inter- and intra-observer reproducibility of the measurement of common carotid artery wall thickness in 13 subjects, using two procedures. The first was a standard echographical investigation. In the second procedure, the principal parameters recorded from the first investigation were used to reposition the beam with the same incident angle.
  
  
  RESULTS
  Intra-observer variability (correlation coefficient, r = 0.61 for procedure 1 and r = 0.77 for procedure 2) and inter-observer variation (r = 0.58 for procedure 1 and r = 0.71 for procedure 2) were reduced when the second investigation was assisted by reproducibility software.
  
  
  CONCLUSIONS
  The proposed method is a reliable and reproducible way of assessing combined intimal and medial wall thickness in the common carotid artery. It may be possible to improve reproducibility using specific software to aid the operator. Since the intimal and medial thickness of the common carotid artery appears to be a sensitive marker of vascular risk, the proposed standardized method of measuring these parameter may allow early detection and assessment of changes.
authors.affiliation: Centre for Neurovascular Diagnosis and Prevention, Paris, France.
authors.forename: P J
authors.initials: PJ
authors.lastname: Touboul
authors.forename: P
authors.initials: P
authors.lastname: Prati
authors.forename: P Y
authors.initials: PY
authors.lastname: Scarabin
authors.forename: V
authors.initials: V
authors.lastname: Adrai
authors.forename: E
authors.initials: E
authors.lastname: Thibout
authors.forename: P
authors.initials: P
authors.lastname: Ducimetière
mesh_terms: D000368:Aged; D002339:Carotid Arteries / Q000033:anatomy & histology / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D015588:Observer Variation; D015203:Reproducibility of Results; D012984:Software; D014463:Ultrasonography / Q000379:methods