Sequence of a canine cDNA clone encoding a Ran/TC4 GTP-binding protein.
We report the isolation and characterization of a canine cDNA encoding a 216-amino acid GTP-binding protein of the Ras superfamily. The protein is almost identical to the human TC4 [Drivas et al., Mol. Cell. Biol. 10 (1990) 1793-1798] and Ran [Bischoff and Ponstingl, Proc. Natl. Acad. Sci. USA 88 (1991) 10830-10834; Nature 354 (1991) 80-82] proteins, the latter of which has been found to be involved in cell cycle control. Furthermore, the protein is highly similar to the fission yeast spi1 gene product [Matsumoto and Beach, Cell 66 (1991) 347-360]. The high degree of evolutionary conservation in this protein suggests that it plays a vital role in the eukaryotic cell.
Dupree
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Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany.
Olkkonen
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Chavrier
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D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D004247:DNA / Q000235:genetics* / Q000302:isolation & purification; D004285:Dogs; D019204:GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000235:genetics*; D016366:Open Reading Frames; D017386:Sequence Homology, Amino Acid; D020931:ran GTP-Binding Protein
D009687:Nuclear Proteins; D004247:DNA; D019204:GTP-Binding Proteins; D020931:ran GTP-Binding Protein