title: Schistosoma mansoni: peritoneal plasmacytogenesis and polypoid transformation of mesenteric milky spots in infected mice.
abstract: We have studied inflammatory reactions in the mesenteric tissue of mice infected with Schistosoma mansoni. Perivascular tissue contained diffuse infiltrates of macrophages, eosinophilic granulocytes and lymphocytes. Angiogenesis in the perivascular adipose tissue was associated with superficial plasmacytogenic foci. Polypoid structures were occasionally formed adjacent to inflammatory foci in the adipose tissue, organized around loops of capillaries, with terminal formation of a glomerular capillary network embedded in connective tissue, covered by plasmacytes. We conclude that these structures are specialized milky spots dedicated to active plasmacytogenesis and antibody secretion into the peritoneal cavity of schistosome-infected mice.
authors.affiliation: Departamento de Bioquímica, Universidade Federal do Rio de Janeiro, Brazil.
authors.forename: D F
authors.initials: DF
authors.lastname: Weinberg
authors.forename: E
authors.initials: E
authors.lastname: Baldo-Correa
authors.forename: H L
authors.initials: HL
authors.lastname: Lenzi
authors.forename: R
authors.initials: R
authors.lastname: Borojevic
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000818:Animals; D002196:Capillaries / Q000473:pathology; D002454:Cell Differentiation; D002908:Chronic Disease; D005260:Female; D006098:Granulocytes / Q000276:immunology; D007249:Inflammation; D008214:Lymphocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D008297:Male; D008643:Mesentery / Q000098:blood supply / Q000276:immunology* / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D009389:Neovascularization, Pathologic; D010529:Peritoneal Cavity / Q000098:blood supply / Q000473:pathology*; D010950:Plasma Cells / Q000276:immunology* / Q000648:ultrastructure; D012555:Schistosomiasis mansoni / Q000276:immunology* / Q000473:pathology