[Effect of 764-3 on histamine content in the lungs during inflammation and on the proliferation of lung fibroblasts].
The changes of histamine content in inflamed lungs induced by bleomycin, lung fibroblast proliferation enhanced by histamine and the effect of 764-3 on these parameters were investigated. Results showed that: 1) after intratracheal instillation of bleomycin for 7 and 21 days, the lung histamine content increased significantly, and 764-3 inhibited this increase of histamine content; 2) histamine enhanced the proliferation of lung fibroblasts in a dose- and time-dependent manner, and 764-3 inhibited the proliferation of lung fibroblasts in both normal and histamine-enhanced conditions. Results suggested that both inhibitory actions (direct inhibition of fibroblast proliferation and indirect action stemming from a reduction in the histamine content increase) might be involved in the antifibrotic mechanism of 764-3.
Liu
Q
Q
Institute of Basic Medical Sciences, Beijing.
D000818:Animals; D001761:Bleomycin; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005347:Fibroblasts / Q000166:cytology; D006632:Histamine / Q000032:analysis* / Q000494:pharmacology; D008168:Lung / Q000737:chemistry* / Q000473:pathology; D008297:Male; D011014:Pneumonia / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D004365:Drugs, Chinese Herbal; D001761:Bleomycin; D006632:Histamine