[Study on the interaction between hypertension, smoking and the disorder of lipids metabolism in the coronary artery disease].
The correlations of the coronary artery disease (CAD) and hypertension, smoking and/or the levels of lipoproteins and apolipoproteins, were studied in 100 patients with CAD diagnosed by coronary arteriography and 141 non-CAD controls. The findings are: 1. There are: significant positive dose-response relationships between the degrees of CAD and the levels of diastolic pressure, cumulative smoking consumptions, the levels of high-density lipoprotein subclasses and apolipoproteins A1 and/or B. 2. The degrees of CAD in patients with the hypertension and smoking at same time were more serious than those with only a single risk factor. It's suggested that there are some synergy between hypertension and smoking in the occurrence of CAD. The synergic mechanism may be related to lipids metabolism.
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Department of Epidemiology, Fourth Military Medical University, Xian.
D003327:Coronary Disease / Q000209:etiology*; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications*; D006973:Hypertension / Q000150:complications*; D008074:Lipoproteins / Q000378:metabolism; D008297:Male; D015999:Multivariate Analysis; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*
D008074:Lipoproteins