title: Reproductive behaviour following spontaneous loss of pregnancy after prenatal diagnosis.
abstract: One hundred and fifty-eight women of advanced maternal age with complete follow up who experienced spontaneous fetal loss after prenatal diagnosis were studied for reproductive behaviour as well as prenatal diagnosis in a subsequent pregnancy. A higher rate of subsequent pregnancies amongst women who experienced an early spontaneous abortion after chorionic villus sampling (CVS) was expected compared with women who lost a pregnancy later during pregnancy after amniocentesis. Of the 92 women who underwent CVS in a previous pregnancy, 57 (62%) became pregnant again. Of the 66 women who underwent amniocentesis in the pregnancy that ended in fetal loss, 34 women (52%) had a subsequent pregnancy. The cumulative incidence of subsequent pregnancies was significantly influenced by maternal age but not by parity or the method of prenatal testing. Most women who decided on a new pregnancy opted for prenatal diagnosis. There was a preference for amniocentesis if the patient had previously undergone CVS. However, the reverse was not the case.
authors.affiliation: Department of Obstetrics and Gynecology, Academic Hospital Rotterdam-Dijkzigt, Erasmus University, The Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Brandenburg
authors.forename: J
authors.initials: J
authors.lastname: Groenhuijzen
authors.forename: M G
authors.initials: MG
authors.lastname: Jahoda
authors.forename: T
authors.initials: T
authors.lastname: Stijnen
authors.forename: M A
authors.initials: MA
authors.lastname: de Ridder
authors.forename: E S
authors.initials: ES
authors.lastname: Sachs
authors.forename: J W
authors.initials: JW
authors.lastname: Wladimiroff
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology*; D000328:Adult; D000649:Amniocentesis / Q000706:statistics & numerical data*; D015193:Chorionic Villi Sampling / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008423:Maternal Age; D009426:Netherlands / Q000453:epidemiology; D011247:Pregnancy / Q000706:statistics & numerical data*; D018566:Pregnancy, High-Risk