title: Comparative coherence studies in healthy volunteers and Down's syndrome patients from childhood to adult age.
abstract: Within the scope of the Munich Pediatric Longitudinal Study, EEG coherence was studied in 212 Down's syndrome patients and 342 healthy controls aged from 6 months up to 30 years. The digitalized EEG records were subjected to spectral analysis. Frequency band-related coherences were calculated to reveal age-specific differences in the functional relationship between two brain areas in Down's syndrome patients and controls. The results show that in the "eyes-open" state the intra-hemispheric coherence in the alpha band was significantly lower (P less than 0.05) in the Down's syndrome patients than in the controls whereas that in the delta bands it was generally higher. The intra-hemispheric coherence in the "eyes-closed" state was generally higher in the Down's syndrome groups than in the controls; however, significant differences could be detected only in some age groups. The age-specific development of coherence in the inter-hemispheric parieto-occipital region was almost identical in Down's syndrome children as in controls, both with open and closed eyes. The most distinct differences were found in the fronto-central inter-hemispheric coherence (P less than 0.01), while the coherence deficiencies in the Down's syndrome group became more prominent with increasing age from school age onwards. These electrophysiological results are compared with the results of neuropathological and neurophysiological studies of other authors. It can be suggested that there are correlations with a significantly small number of dendritic spines in Down's syndrome patients, which was determined in neuropathological examinations. A neuronal model of interpretation is presented which explains the increasing developmental deficit with age in Down's syndrome children.
authors.affiliation: Institut für Soziale Pädiatrie und Jugendmedizin, Universität München, F.R.G.
authors.forename: R G
authors.initials: RG
authors.lastname: Schmid
authors.forename: W S
authors.initials: WS
authors.lastname: Tirsch
authors.forename: P
authors.initials: P
authors.lastname: Rappelsberger
authors.forename: H M
authors.initials: HM
authors.lastname: Weinmann
authors.forename: S J
authors.initials: SJ
authors.lastname: Pöppl
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000502:physiology; D000704:Analysis of Variance; D001143:Arousal / Q000502:physiology; D001921:Brain / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000503:physiopathology*; D004569:Electroencephalography; D006801:Humans; D007223:Infant; D011930:Reaction Time / Q000502:physiology