title: Iloprost in cardiopulmonary bypass procedures.
abstract: The inhibition of platelet aggregation during cardiopulmonary bypass and effects on post-operative placebo-controlled study of 145 patients. Significant preservation of platelet numbers and function were shown without significant haemodynamic problems, but no effect on cerebral deficits could be found. The use of iloprost in patients with severe thrombocytopenia seems justified, but the clinical benefits from its use in routine cardiopulmonary bypass remain to be shown.
authors.affiliation: Cardiovascular Clinical Research Unit, Schering Health Care, West Sussex, England.
authors.forename: H R
authors.initials: HR
authors.lastname: Watson
authors.forename: G
authors.initials: G
authors.lastname: Belcher
authors.forename: J K
authors.initials: JK
authors.lastname: Brierley
authors.forename: W P
authors.initials: WP
authors.lastname: Dole
mesh_terms: D001803:Blood Transfusion; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D016285:Iloprost / Q000627:therapeutic use*; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count; D011183:Postoperative Complications / Q000517:prevention & control*; D011597:Psychomotor Performance / Q000187:drug effects
chemical_list: D016285:Iloprost