Effect of human chorionic gonadotropin (hCG) on reverse transcriptase activity in HIV-1 infected lymphocytes and monocytes.
The majority of infants born to HIV-positive mothers are not infected in utero, suggesting that the pregnancy factors produced by fetal trophoblasts may provide protection against HIV-1 infection. Except for steroid female hormones, little is known of other pregnancy factors that may regulate either resistance or susceptibility to HIV-1. Human chorionic gonadotropin (hCG)--the major glycoprotein produced by the placental trophoblast throughout the pregnancy--was tested on reverse transcriptase activity in HIV-infected ACH-2 lymphocytes and U1 monocytes. The results suggest that low non-cytotoxic doses of hCG (0.01-1.0 IU range) may inhibit viral replication in maternal blood cells.
Bourinbaiar
A S
AS
Population Council, Center for Biomedical Research, New York, NY.
Nagorny
R
R
D002478:Cells, Cultured; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D054303:HIV Reverse Transcriptase; D015497:HIV-1 / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D006801:Humans; D008214:Lymphocytes / Q000382:microbiology*; D009000:Monocytes / Q000382:microbiology*; D012194:RNA-Directed DNA Polymerase / Q000187:drug effects*; D014779:Virus Replication / Q000187:drug effects
D006063:Chorionic Gonadotropin; D054303:HIV Reverse Transcriptase; D012194:RNA-Directed DNA Polymerase