Tissue response to intraperitoneal implants of polyethylene oxide-modified polyethylene terephthalate.
Polyethylene terephthalate films surface modified with polyethylene oxide of mol wt 18,500 g/mol (18.5 k) by a previously described technique, were implanted in the peritoneal cavity of mice, along with their respective untreated controls, for periods of 1-28 d. The implants were retrieved and examined for tissue reactivity and cellular adherence. The control polyethylene terephthalate surfaces showed an initial inflammatory reaction followed by an extensive fibrotic response with a mean thickness of 60 microns at 28 d. By contrast, polyethylene oxide-modified polyethylene terephthalate showed only a mild inflammatory response and no fibrotic encapsulation throughout the implantation period: at 28 d a cellular monolayer was observed. Apparently either the polyethylene oxide-modified surface was stimulating less inflammation, which was in turn stimulating less fibroblastic overgrowth, or the cellular adhesion to the polyethylene oxide-modified surface was too weak to support cellular multilayers.
Desai
N P
NP
Department of Chemical Engineering, University of Texas, Austin 78712-1062.
Hubbell
J A
JA
D000818:Animals; D001672:Biocompatible Materials; D005549:Foreign-Body Reaction / Q000473:pathology; D008297:Male; D008422:Materials Testing; D051379:Mice; D008813:Mice, Inbred ICR; D010529:Peritoneal Cavity; D011092:Polyethylene Glycols; D011093:Polyethylene Terephthalates; D019736:Prostheses and Implants
D001672:Biocompatible Materials; D011093:Polyethylene Terephthalates; D011092:Polyethylene Glycols