title: [Pharmacokinetic studies of menogaril (TUT-7) with rats].
abstract: Menogaril (TUT-7) is a novel antitumor antibiotic belonging to anthracyclines. The pharmacokinetic parameters derived from plasma concentration-time profiles after repeated (for 14 days) or single oral administration of TUT-7 to rats were found to be not significantly different by either administration schedule. The rats with artificial liver dysfunction were obtained by subcutaneous application of carbon tetrachloride (CCl4, 1 ml/kg) for 3 days. After oral administration of TUT-7 to the rats with CCl4-induced liver toxicity (3 daily administrations of 1mg/kg, S.C.), the maximum plasma concentrations (Cmax) and AUC of both the unchanged drug and its metabolite N-Demethyl menogaril, were increased. Also over all elimination was slower in animals with liver dysfunction.
authors.affiliation: Division of Clinical Pharmacology Center, Nippon Medical School, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ohashi
authors.forename: H
authors.initials: H
authors.lastname: Hara
authors.forename: F
authors.initials: F
authors.lastname: Takahashi
authors.forename: R
authors.initials: R
authors.lastname: Aso
authors.forename: T
authors.initials: T
authors.lastname: Akimoto
authors.forename: K
authors.initials: K
authors.lastname: Nakama
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D002252:Carbon Tetrachloride Poisoning / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury; D008107:Liver Diseases / Q000097:blood; D008297:Male; D017290:Menogaril; D009621:Nogalamycin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D051381:Rats
chemical_list: D000970:Antineoplastic Agents; D017290:Menogaril; D009621:Nogalamycin