A prospective study of skeletal changes during short-term acitretin therapy.
We prospectively analyzed skeletal changes of 16 patients who were treated with acitretin for various disorders of keratinization at doses of 10-50 mg/day (overall mean 0.4 mg/kg/day) for 7-12 months (mean 11.4 months). Skeletal changes from pretherapy findings were observed in 5 patients. In 4 of 5 patients they appeared to be linked to a preexisting degenerative pathology and could not be attributed to acitretin therapy. However, in 1 patient a spinal osseous side effect could not be excluded. No retinoid-induced extraspinal tendon or ligament calcifications were observed.
Hohl
D
D
Department of Dermatology, University Hospital, Zurich, Switzerland.
Pelloni
F
F
Sigg
C
C
Gilardi
S
S
Jung
T
T
D017255:Acitretin; D000293:Adolescent; D001847:Bone Diseases / Q000139:chemically induced*; D001842:Bone and Bones / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012871:Skin Diseases / Q000188:drug therapy*; D013122:Spinal Diseases / Q000139:chemically induced; D014212:Tretinoin / Q000009:adverse effects / Q000031:analogs & derivatives*
D014212:Tretinoin; D017255:Acitretin