Comparison of intubating conditions after administration of Org 9246 (rocuronium) and suxamethonium.
We have assessed intubating conditions after administration of Org 9426 (rocuronium) 600 micrograms kg-1 at 60 or 90 s in groups of 20 patients anaesthetized with thiopentone, nitrous oxide in oxygen and small doses of fentanyl, and compared the data with those obtained after suxamethonium 1 mg kg-1 in similar groups of patients. The influence of prior suxamethonium administration on the potency of Org 9426 was studied also by constructing a dose-response curve. Intubating conditions after Org 9426 were found to be clinically acceptable (good or excellent) in 95% of patients at 60 s and in all patients at 90 s and in all patients at both times after suxamethonium. The average time for the onset of block following Org 9426 at this dose was 89 s (which is shorter than with any of the currently available non-depolarizing neuromuscular blocking drugs); the duration of clinical relaxation (25% recovery of twitch height) 30 min. Prior administration of suxamethonium did not appear to influence the potency of Org 9426.
Cooper
R
R
Department of Anaesthetics, Queen's University of Belfast.
Mirakhur
R K
RK
Clarke
R S
RS
Boules
Z
Z
D000293:Adolescent; D000328:Adult; D000368:Aged; D000732:Androstanols / Q000494:pharmacology*; D000758:Anesthesia; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007442:Intubation, Intratracheal; D008875:Middle Aged; D009126:Muscle Relaxation / Q000187:drug effects; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D000077123:Rocuronium; D013390:Succinylcholine / Q000494:pharmacology*; D013997:Time Factors
D000732:Androstanols; D009466:Neuromuscular Blocking Agents; D013390:Succinylcholine; D000077123:Rocuronium