The human squamous cervical carcinoma cell line, HOG-1, is responsive to steroid hormones.
Growth of the human squamous cervical carcinoma cell line, HOG-I, was stimulated in response to oestradiol in serum-containing and chemically defined medium. The oestradiol-stimulated growth could be inhibited by 4-OH tamoxifen, progesterone and medroxyprogesterone acetate; the last 2 compounds also inhibited basal cell growth in serum-containing and chemically defined media. The data are consistent with the sensitivity of human squamous cervical cancer to sex-steroid hormones and suggest that endocrine therapies may be of benefit in this disease.
White
J O
JO
Institute of Obstetrics and Gynaecology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Jones
R N
RN
Croxtall
J D
JD
Gleeson
R P
RP
Krausz
T
T
Pervez
S
S
Jamil
A
A
Guida
L
L
Beesley
J E
JE
Soutter
W P
WP
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000188:drug therapy* / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D003470:Culture Media; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008525:Medroxyprogesterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D017258:Medroxyprogesterone Acetate; D013629:Tamoxifen / Q000031:analogs & derivatives* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D002583:Uterine Cervical Neoplasms / Q000737:chemistry / Q000188:drug therapy* / Q000473:pathology
D003470:Culture Media; D013629:Tamoxifen; C016601:afimoxifene; D004958:Estradiol; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone