title: Effect of antineoplastic agents on smooth muscle cell proliferation in vitro: implications for prevention of restenosis after transluminal angioplasty.
abstract: The effect of several antineoplastic agents on vascular smooth muscle cell proliferation was studied in vitro. Both fluorouracil and cytarabine produced significant concentration-dependent inhibition of smooth muscle cell proliferation in cultured porcine pulmonary artery in vitro, while cyclophosphamide stimulated growth. For fluorouracil, inhibition was near maximal at a concentration of 13.0 microgram/mL and was seen with both coincubation and 2-hour preincubation of fluorouracil with quiescent cells. Fluorouracil is a promising agent for inhibition of intimal proliferation. Further work is warranted to determine its effect in vivo.
authors.affiliation: Department of Radiology, University of Iowa College of Medicine, Iowa City.
authors.forename: A H
authors.initials: AH
authors.lastname: Cragg
authors.forename: L L
authors.initials: LL
authors.lastname: Stoll
authors.forename: T P
authors.initials: TP
authors.lastname: Smith
authors.forename: K
authors.initials: K
authors.lastname: Berbaum
mesh_terms: D000800:Angioplasty, Balloon; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003251:Constriction, Pathologic; D003520:Cyclophosphamide / Q000494:pharmacology; D003561:Cytarabine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005472:Fluorouracil / Q000494:pharmacology; D009131:Muscle, Smooth, Vascular / Q000166:cytology* / Q000187:drug effects; D011651:Pulmonary Artery / Q000166:cytology; D012008:Recurrence; D013552:Swine
chemical_list: D000970:Antineoplastic Agents; D003561:Cytarabine; D003520:Cyclophosphamide; D005472:Fluorouracil