Recombinant factor VIIa in an infant with haemophilia A and inhibitors.
Post-traumatic bleeding from the gingiva in a 16-month-old boy with severe haemophilia A did not stop after treatment with factor VIII concentrate and tranexamic acid, and it was demonstrated that he had developed antibodies to factor VIII. Treatment with recombinant factor VIIa 60-90 micrograms/kg body weight four to eight times daily, together with local measures, stopped the bleeding and no complications were seen.
Tengborn
L
L
Section of Coagulation Disorders, Sahlgren's Hospital, Göteborg, Sweden.
Kjellman
B
B
Elfstrand
P O
PO
Bågenholm
T
T
D005169:Factor VIII / Q000276:immunology*; D015942:Factor VIIa / Q000627:therapeutic use*; D006467:Hemophilia A / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007223:Infant; D007518:Isoantibodies; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use
D007518:Isoantibodies; D011994:Recombinant Proteins; D005169:Factor VIII; D015942:Factor VIIa