Hormonal effects of zinc on growth in children.
Zinc deficiency impairs the metabolism of thyroid hormones, androgens, and above all growth hormones. In view of their important role in growth, it is not surprising to find growth disorders associated with zinc deficiency. Stunted growth linked to zinc deficiency is found during gestation, and also in the newborn and children up to adolescence. Depending on the country, 5-30% of children suffer from moderate zinc deficiency, responsible for small-for-age height. Zinc supplementation has proven effective in many studies, mainly in children where zinc deficiency has first been found. Finally, zinc supplementation makes it possible in certain cases to overcome resistance to growth hormone treatment.
Favier
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Laboratoire de Biochimie des intéractions Micronutriments, Université Joseph Fourier, Faculté de Pharmacie, La Tronche, France.
D000293:Adolescent; D000328:Adult; D002648:Child; D002657:Child Development / Q000502:physiology; D002675:Child, Preschool; D005260:Female; D006128:Growth / Q000502:physiology*; D006728:Hormones / Q000502:physiology*; D006801:Humans; D007223:Infant; D008297:Male; D009752:Nutritional Status; D011247:Pregnancy; D015032:Zinc / Q000494:pharmacology / Q000502:physiology*
D006728:Hormones; D015032:Zinc