TDM35--a new monoclonal antibody to the XH1 cervical carcinoma cell line. Characterization and immunoperoxidase localization in benign and malignant tissues.
The murine monoclonal IgG1 kappa antibody TDM35 was raised against the cervical carcinoma cell line XH1. The antibody recognizes 18.5-66 kDa NCA-like glycoproteins and immunostains a variety of formalin-fixed, paraffin-embedded normal, benign, and malignant tissues. It is of value in the diagnosis of carcinoma of the exocrine pancreas and it identifies foci of squamous and glandular differentiation in other tumours. TDM35 should form a useful addition to a panel of antibodies for the evaluation of epithelial lesions.
Chana
T
T
Department of Histopathology, UMDS, St Thomas Hospital, London, U.K.
Han
X
X
Dagg
B
B
Lawrie
A S
AS
Gooding
R P
RP
Eustace
D L
DL
Fletcher
C D
CD
Heyderman
E
E
D000230:Adenocarcinoma / Q000175:diagnosis; D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007145:Immunoglobulin kappa-Chains / Q000276:immunology; D008175:Lung Neoplasms / Q000175:diagnosis; D051379:Mice; D008807:Mice, Inbred BALB C; D010190:Pancreatic Neoplasms / Q000175:diagnosis; D014407:Tumor Cells, Cultured / Q000276:immunology; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000276:immunology*
D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains