title: In vivo studies of ethanol on prolactin and luteinizing hormone in rats and mice.
abstract: The interaction of ethanol (EtOH), prolactin (Prl) and luteinizing hormone (LH) was examined in two studies. In the first study, adult male C57B1/6J mice were given a single intraperitoneal injection of either vehicle or Prl at 5, 10 and 20 mg/kg and a significant dose-related suppression of ethanol consumption was found. This injection did not cause any differences in food intake or body weight. Additionally, a 5 mg/kg dose of Prl was also given to adult male Long Evans Hooded rats and, similarly, there was a significant suppression of ethanol consumption. In a second study, when rats were given a free choice between water and 5% EtOH, three subgroups were found regarding the amount of EtOH consumption: low, medium and high. After 2 weeks of free choice, hypothalamic, but not serum Prl and LH levels, were significantly increased in EtOH-imbibing groups compared to controls. These findings suggest important interactions between EtOH consumption and ambient levels of Prl and LH.
authors.affiliation: Department of RMS, Dayton VA Medical Center, OH.
authors.forename: C
authors.initials: C
authors.lastname: Ho
authors.forename: N V
authors.initials: NV
authors.lastname: Emanuele
authors.forename: L
authors.initials: L
authors.lastname: Kirsteins
authors.forename: A M
authors.initials: AM
authors.lastname: Lawrence
mesh_terms: D000428:Alcohol Drinking; D000818:Animals; D004327:Drinking Behavior / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011388:Prolactin / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000431:Ethanol; D011388:Prolactin; D007986:Luteinizing Hormone