Folipastatin, a new depsidone compound from Aspergillus unguis as an inhibitor of phospholipase A2. Taxonomy, fermentation, isolation, structure determination and biological properties.
A new inhibitor of phospholipase A2 was isolated from the fermentation broth of Aspergillus unguis. The structure, with a depsidone carbon skeleton, was assigned by spectroscopic experiments.
Hamano
K
K
Fermentation Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
Kinoshita-Okami
M
M
Hemmi
A
A
Sato
A
A
Hisamoto
M
M
Matsuda
K
K
Yoda
K
K
Haruyama
H
H
Hosoya
T
T
Tanzawa
K
K
D000818:Animals; D001230:Aspergillus / Q000145:classification* / Q000378:metabolism; D005285:Fermentation; D007783:Lactones / Q000302:isolation & purification* / Q000494:pharmacology; D009568:Nitrendipine / Q000378:metabolism; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2; D013552:Swine
D007783:Lactones; C077320:folipastatin; D009568:Nitrendipine; D010741:Phospholipases A; D054467:Phospholipases A2