title: Hypofibrinogenemia due to fibrin formation in subserosal type eosinophilic gastroenteropathy.
abstract: A 33-year-old woman presented with abdominal pain and distention, diarrhoea and marked eosinophilia in blood and ascites. As other causes could be excluded, the subserosal type of eosinophilic gastroenteropathy was diagnosed. The low plasma fibrinogen level (less than 100 mg/100 ml) found in this patient is an as yet undescribed feature. During prednisolone therapy it increased concurrently with the fall of blood eosinophils and the relief of clinical symptoms. Interest was further directed to the ascitic fluid where not only the presence of eosinophils (74%) enveloped in fibrin yarn and of basophils (2%) but also of 24% T lymphocytes (among them 75% CD4+, 24% CD8+, 4% CD25+, less than 1% CD19+, less than 1% natural killer cells) could be demonstrated. These lymphocytes are likely to be the source for lymphokine production chemoattracting eosinophils into the intestine. In addition they seem to be involved in IgE hyperproduction, which after adequate therapy and complete resolution of the clinical symptoms, tended to decrease slowly.
authors.affiliation: 1. Medizinische Universitätsklinik, Wien, Osterreich.
authors.forename: E
authors.initials: E
authors.lastname: Presterl
authors.forename: L
authors.initials: L
authors.lastname: Wagner
authors.forename: W
authors.initials: W
authors.lastname: Base
mesh_terms: D000328:Adult; D000347:Afibrinogenemia / Q000175:diagnosis / Q000209:etiology*; D004802:Eosinophilia / Q000150:complications*; D005260:Female; D005337:Fibrin / Q000096:biosynthesis; D005767:Gastrointestinal Diseases / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D011239:Prednisolone / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000473:pathology
chemical_list: D005337:Fibrin; D011239:Prednisolone