Protective effects of ether, oxygen and their mixture for radiation in Drosophila melanogaster.
Protective effects of ether mixed with air or oxygen against ionizing radiation damages were demonstrated in adult flies of Drosophila melanogaster. The protective effects against knock-down on the 2nd day and lethality on the 8th day after irradiation were not affected by the radiation sensitivity and DNA repair capacity of the strains. Ether (4.2%) in oxygen was more effective than ether in air for both endpoints. The protective effects may be due to damages not involving cell division, since no mitotic cells are observed in adult flies except in gonadal glands. A change in the orderliness of the cell membrane by ether is suggested to be the cause of the protective effects.
Megumi
T
T
Research Institute for Science and Technology, University of Osaka Prefecture, Japan.
Gamo
S
S
Tsujii
Y
Y
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D004331:Drosophila melanogaster / Q000187:drug effects / Q000528:radiation effects*; D004351:Drug Resistance; D004986:Ether / Q000494:pharmacology*; D005720:Gamma Rays; D010100:Oxygen / Q000494:pharmacology; D011837:Radiation-Protective Agents
D011837:Radiation-Protective Agents; D004986:Ether; D010100:Oxygen