title: Significantly higher frequency of the MspI 2.2 kb allele of the Duchenne muscular dystrophy intragenic probe P-20 in the Chinese population.
abstract: The P-20 intragenic marker was used to test for restriction fragment length polymorphisms in unrelated Chinese patients with Duchenne or Becker muscular dystrophy or X-linked mental retardation. In addition to polymorphism at the 6.0/3.5 kb MspI allelic site, we found an independent and high frequency of polymorphism at the 2.2/1.8 kb site. This differs from results found with other populations.
authors.affiliation: Department of Medical Genetics, Shandong Medical University, Jinan, People's Republic of China.
authors.forename: J
authors.initials: J
authors.lastname: Wei
authors.forename: Y
authors.initials: Y
authors.lastname: Guo
authors.forename: B
authors.initials: B
authors.lastname: Chen
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China; D015342:DNA Probes / Q000235:genetics; D019003:Deoxyribonuclease HpaII; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism; D005787:Gene Frequency; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D009136:Muscular Dystrophies / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D014960:X Chromosome
chemical_list: D015342:DNA Probes; D005819:Genetic Markers; D019003:Deoxyribonuclease HpaII; D015252:Deoxyribonucleases, Type II Site-Specific