Synthesis and antibacterial activity of some imidazo[1,2-a]pyrimidine derivatives.
A series of 75 imidazo[1,2-a]pyrimidine derivatives were synthesized. The "in vitro" antibacterial activity of these compounds and their corresponding alpha-bromoketones against a variety of gram (+), gram (-) bacteria and Mycobacterium species is reported. Some of the prepared derivatives exhibited potent antimicrobial activity.
Rival
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Laboratoire de Chimie Organique, Faculté de Pharmacie, Illkirch, France.
Grassy
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G
Michel
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G
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D007093:Imidazoles; D011743:Pyrimidines