Association between serum-soluble CD8 levels and parameters of immune activation in patients with human immunodeficiency virus infection.
We compared the serum concentrations of soluble CD8 with the immune activation markers neopterin, interferon-gamma, tumour necrosis factor-alpha, soluble CD4, and with CD4+ and CD8+ T-cell counts in patients with human immunodeficiency virus (HIV) infection. The majority of patients had increased concentrations of soluble CD8, interferon-gamma and neopterin, and various significant correlations existed between them. Our results support the view that enhanced soluble CD8 levels indicate activated CD8+ T cells in patients with HIV infection.
Tilz
G P
GP
Klinische Immunologie und Immunhämatologie, Universität Graz.
Zangerle
R
R
Weiss
G
G
Fritsch
P
P
Wachter
H
H
Fuchs
D
D
D000328:Adult; D015415:Biomarkers / Q000097:blood; D016827:CD8 Antigens / Q000097:blood*; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D012995:Solubility
D015415:Biomarkers; D016827:CD8 Antigens