title: Effects of lasalocid on selected ruminal and blood metabolites in young calves.
abstract: Twelve Holstein bull calves were ruminally cannulated at 5 d of age and assigned to 0 or 1 mg of lasalocid/kg of BW daily, administered postruminally via milk replacer or into the ruminal cannula. Calves were fed milk replacer for 8 wk and calf starter for 12 wk. Lasalocid administration was terminated at weaning in calves fed lasalocid in milk replacer. Ruminal pH tended to be higher in calves fed lasalocid ruminally than in calves on control treatment and averaged 5.9 and 5.6 and 5.4 and 5.1 during wk 1 to 8 and 9 to 12, respectively. Molar proportion of ruminal butyrate tended to be lower when lasalocid was added to the rumen, particularly after weaning. Blood beta-hydroxybutyrate and acetoacetate were lower when lasalocid was administered into the rumen after weaning and averaged .897 and .646 and .026 and .015 mM in calves on control and ruminal treatments, respectively. No effects of lasalocid administered via the milk replacer were observed, except for plasma NEFA, which were reduced postweaning. These data suggest that lasalocid reduces blood beta-hydroxybutyrate by changes in ruminal fermentation and subsequent metabolism of butyrate by ruminal epithelium.
authors.affiliation: Department of Animal Science, University of Tennessee, Knoxville 37901-1071.
authors.forename: J D
authors.initials: JD
authors.lastname: Quigley
authors.forename: S I
authors.initials: SI
authors.lastname: Boehms
authors.forename: T M
authors.initials: TM
authors.lastname: Steen
authors.forename: R N
authors.initials: RN
authors.lastname: Heitmann
mesh_terms: D020155:3-Hydroxybutyric Acid; D000090:Acetoacetates / Q000097:blood; D000818:Animals; D002087:Butyrates / Q000378:metabolism; D020148:Butyric Acid; D002264:Carboxylic Acids / Q000097:blood / Q000378:metabolism*; D002417:Cattle / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006863:Hydrogen-Ion Concentration; D006885:Hydroxybutyrates / Q000097:blood; D007659:Ketones / Q000097:blood / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D007832:Lasalocid / Q000494:pharmacology*; D008297:Male; D012417:Rumen / Q000187:drug effects / Q000378:metabolism*
chemical_list: D000090:Acetoacetates; D002087:Butyrates; D002264:Carboxylic Acids; D005230:Fatty Acids, Nonesterified; D006885:Hydroxybutyrates; D007659:Ketones; D007773:Lactates; D020148:Butyric Acid; D019344:Lactic Acid; C016635:acetoacetic acid; D020155:3-Hydroxybutyric Acid; D007832:Lasalocid