Inhibition of the activation of Hageman factor (factor XII) by aprotinin (Trasylol)
Aprotinin (Trasylol; Bayer AG, Leverkusen, Germany), a protease inhibitor resembling or identical with Kunitz' pancreatic trypsin inhibitor, is said to have anticoagulant properties, but these are not clearly defined. The present study provides evidence that one action of aprotinin is inhibition of the activation of Hageman factor (factor XII).
Laurel
M T
MT
Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
Ratnoff
O D
OD
Everson
B
B
D007611:Aprotinin / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D004610:Ellagic Acid / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D005170:Factor X / Q000378:metabolism; D005174:Factor XII / Q000378:metabolism*; D005898:Glass; D006801:Humans; D066298:In Vitro Techniques; D013433:Sulfoglycosphingolipids / Q000037:antagonists & inhibitors / Q000494:pharmacology
D013433:Sulfoglycosphingolipids; D004610:Ellagic Acid; D005170:Factor X; D005174:Factor XII; D007611:Aprotinin