Transplantation of organs between species.
The shortage of organs from human donors for transplantation has stimulated a renewed interest in the use of organs from animals or xenografting. Such grafts can be transplanted between closely related species--concordant, or distantly related species--discordant. In this mini review the immune processes which cause rejection for each of these categories is described. Data demonstrating methods by which this rejection can be controlled are summarised and a possible approach to clinical application is described.
White
D J
DJ
Department of Surgery, University of Cambridge, Addenbrookes Hospital, UK.
D000818:Animals; D015703:Antigens, CD; D018958:CD55 Antigens; D003165:Complement System Proteins / Q000502:physiology; D006224:Cricetinae; D003520:Cyclophosphamide / Q000494:pharmacology; D007166:Immunosuppressive Agents / Q000494:pharmacology; D051916:Membrane Cofactor Protein; D008562:Membrane Glycoproteins / Q000502:physiology; D008565:Membrane Proteins / Q000502:physiology; D051379:Mice; D051381:Rats; D011923:Rats, Nude; D016019:Survival Analysis; D014183:Transplantation, Heterologous
D015703:Antigens, CD; D018958:CD55 Antigens; C497860:Cd46 protein, rat; D007166:Immunosuppressive Agents; C497859:Mcp protein, mouse; D051916:Membrane Cofactor Protein; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D003520:Cyclophosphamide; D003165:Complement System Proteins