title: Effect of recombinant porcine somatotropin and dietary protein on pancreatic digestive enzymes in the pig.
abstract: This study was conducted to determine the effect of daily recombinant porcine somatotropin (rpST) injection (0 or 120 micrograms/kg BW) and dietary CP level of the feed (14 or 26% CP) on pancreatic characteristics of growing pigs. Daily injection of rpST did not affect pancreatic weight (P = .885) but did decrease pancreatic amylase content (P = .005). The ratios of amylase:protein and amylase:trypsin were also lowered by daily rpST injection (P = .002 and P = .0002, respectively). There were protein x rpST and protein x rpST x sex interactions for the ratio of amylase:chymotrypsin. The CP content of the diet had a greater effect than the injection of rpST on pancreatic characteristics. Pigs consuming the 26% CP diet had significantly higher pancreatic weight (P = .003) and greater total pancreatic chymotrypsin (P = .006) than pigs consuming the 14% CP diet. The ratios of trypsin and chymotrypsin to DNA were also higher in pigs fed the 26% CP diet (P = .007 and P = .005, respectively). These responses were not influenced by sex. Recombinant porcine somatotropin seemed to have a slight effect on porcine pancreatic characteristics; however, dietary protein had a greater effect on pancreatic characteristics in market-weight hogs.
authors.affiliation: Performance Enhancement Research, Upjohn Company, Kalamazoo, MI 49001.
authors.forename: B
authors.initials: B
authors.lastname: Hibbard
authors.forename: J P
authors.initials: JP
authors.lastname: Peters
authors.forename: R Y
authors.initials: RY
authors.lastname: Shen
authors.forename: S T
authors.initials: ST
authors.lastname: Chester
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology; D000681:Amylases / Q000032:analysis; D000818:Animals; D002918:Chymotrypsin / Q000032:analysis; D004044:Dietary Proteins / Q000494:pharmacology*; D005260:Female; D013006:Growth Hormone / Q000494:pharmacology*; D016018:Least-Squares Analysis; D008297:Male; D010179:Pancreas / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology*; D011336:Probability; D011506:Proteins / Q000032:analysis; D011897:Random Allocation; D011994:Recombinant Proteins / Q000494:pharmacology; D013552:Swine / Q000378:metabolism*; D014357:Trypsin / Q000032:analysis
chemical_list: D004044:Dietary Proteins; D011506:Proteins; D011994:Recombinant Proteins; D013006:Growth Hormone; D000681:Amylases; D002918:Chymotrypsin; D014357:Trypsin