title: Effect of thyroid hormone status on the expression of the mRNAs of components of the lipolytic regulatory cascade in brown adipose tissue.
abstract: 1. The levels of mRNAs for RII beta and G beta were about 50% lower in brown adipose tissue (BAT) from hyperthyroid than from hypothyroid rats. 2. Treatment of hypothyroid rats with T3 resulted in a 50% decrease in mRNAs for RII beta and G beta in BAT occurring by 12 hr after treatment. 3. The levels of mRNAs for hormone-sensitive lipase, G alpha s and C alpha in BAT were unchanged by thyroid hormone status. 4. The results suggest that thyroid hormone may be involved in negative regulation of the expression of RII beta and G beta at the transcriptional level in BAT.
authors.affiliation: Department of Medicine, University of Minnesota, Minneapolis 55455.
authors.forename: M P
authors.initials: MP
authors.lastname: Thompson
authors.forename: K A
authors.initials: KA
authors.lastname: Strait
mesh_terms: D002001:Adipose Tissue, Brown / Q000502:physiology*; D000818:Animals; D015152:Blotting, Northern; D015342:DNA Probes; D019204:GTP-Binding Proteins / Q000235:genetics; D008066:Lipolysis / Q000235:genetics*; D008297:Male; D011494:Protein Kinases / Q000235:genetics; D012313:RNA / Q000302:isolation & purification; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D002787:Sterol Esterase / Q000235:genetics; D013963:Thyroid Hormones / Q000502:physiology*
chemical_list: D015342:DNA Probes; D012333:RNA, Messenger; D013963:Thyroid Hormones; D012313:RNA; D011494:Protein Kinases; D002787:Sterol Esterase; D019204:GTP-Binding Proteins