[Treatment of chronic renal failure with Oenothera beinnis L in rats with subtotal nephrectomy].
The effect of orally administered Oenothera Biennis L on chronic renal failure was studied in the partially nephrectomized rats. As compared with the control groups, the group treated with Oenothera showed the following features. 1) Urine protein excretion was reduced; 2) Level of serum cholesterol decreased; 3) Scr maintained the same level as before treatment; 4) Level of PGE1 and PGE2 increased both in renal cortex and medulla; 5) 6-keto PGF1 alpha increased in cortex; 6) Increased TXB2 production was only observed 4 weeks after nephrectomy; 7) Glomerular lesions were more severe in control group. It is concluded that Oenothera Biennis L has beneficial effect on the remnant kidney and may be useful as a kind of conservative treatment for chronic renal failure.
Bi
Z Q
ZQ
Nephrology Division, PUMC Hospital, Beijing.
Bo
Y H
YH
Duan
J H
JH
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000527:Alprostadil / Q000378:metabolism; D000818:Animals; D015232:Dinoprostone / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D007668:Kidney / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D009392:Nephrectomy; D011507:Proteinuria / Q000188:drug therapy; D051381:Rats; D017208:Rats, Wistar; D013929:Thromboxane B2 / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D000527:Alprostadil; D015232:Dinoprostone