Extended use of Fluosol emulsion in acute myocardial ischemia treatment.
An intravenous infusion of Fluosol enhanced significantly the t-PA thrombolysis of the arterio-venous shunt made by insertion of 125I-fibrin clot in rabbits. The plasma radioactivity released through thrombolysis increased in both time and dose-dependent manner after the administration of t-PA. Fluosol in combination with t-PA increased the plasma radioactivity, compared with the t-PA treatment alone at the corresponding dosage. The coronary blood flow was markedly reduced to almost zero after the thrombin injection into narrowed LCX with a clamp in open-chest dogs. An intravenous infusion of Fluosol or Pluronic F-68 solution at a dose of 15 ml/kg significantly shortened the thrombolysis time by intracoronary infusion of urokinase alone. While, little change in the QTc interval of ECG and the plasma CPK-MB activity was observed in the Fluosol group in combination with urokinase, suggesting a myocardial protective action of Fluosol possibly due to its oxygen carrying effect.
Ohyanagi
H
H
First Department of Surgery, School of Medicine Kobe University, Japan.
Saitoh
Y
Y
Uchida
T
T
Watanabe
M
M
Yamanouchi
K
K
Yokoyama
K
K
Mitsuno
T
T
D000818:Animals; D001166:Arteriovenous Shunt, Surgical; D001802:Blood Substitutes / Q000008:administration & dosage / Q000627:therapeutic use*; D004285:Dogs; D004655:Emulsions; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D005466:Fluorocarbons / Q000008:administration & dosage / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D008297:Male; D017202:Myocardial Ischemia / Q000097:blood / Q000628:therapy*; D011817:Rabbits; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage
D001802:Blood Substitutes; D004655:Emulsions; D005466:Fluorocarbons; C050455:fluosol; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator