Virally induced immunosuppression.
A mouse model of virus-triggered, T-cell mediated acquired immunosuppression is analyzed. Lymphocytic choriomeningitis virus initially infects mostly macrophages and antigen-presenting cells; these are destroyed by lymphocytic choriomeningitis virus specific cytotoxic T cells resulting in immunosuppression. Similar immunopathological mechanisms may play a role in acquired immune deficiency syndrome.
Zinkernagel
R M
RM
University of Zurich, Switzerland.
Hengartner
H
H
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D000938:Antigen-Presenting Cells / Q000276:immunology; D006678:HIV / Q000254:growth & development / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology*; D008264:Macrophages / Q000382:microbiology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000914:Antibodies, Viral