Apolipoprotein B immunoreactivity in senile plaque and vascular amyloids and neurofibrillary tangles in the brains of patients with Alzheimer's disease.
Based upon our previous finding of the association of apolipoprotein E (apoE) immunoreactivity with cerebral amyloids and neurofibrillary tangles (NFTs), we examined immunohistochemically whether this is also the case for apolipoprotein B (apoB). Polyclonal antibody to apoB immunosustained senile plaque amyloid, vascular amyloid, subpial amyloid deposits and intracellular NFTs in formalin-fixed, paraffin-embedded brain sections from patients with Alzheimer disease. Hydrated autoclave pretreatment of the sections enhanced the staining of plaque amyloid. The results may suggest a role of apoB in amyloid and NFT formation.
Namba
Y
Y
Department of Neuropathology, Faculty of Medicine, University of Tokyo, Japan.
Tsuchiya
H
H
Ikeda
K
K
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology*; D000682:Amyloid / Q000032:analysis*; D001055:Apolipoproteins B / Q000032:analysis*; D001921:Brain / Q000473:pathology*; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D016874:Neurofibrillary Tangles / Q000473:pathology*; D012016:Reference Values; D013194:Staining and Labeling; D013702:Temporal Lobe / Q000473:pathology
D000682:Amyloid; D001055:Apolipoproteins B