title: Distribution of carbamazepine and its epoxide in blood compartments in adolescent and adult epileptic patients.
abstract: Carbamazepine (CBZ) used in the treatment of epilepsy, is metabolized in man to an active metabolite: carbamazepine 10-11 epoxide (CBZ-E). CBZ and CBZ-E concentrations in the different blood compartments (plasma ultrafiltrate, plasma proteins, and red blood cells (RBC)) of epileptic patients on CBZ monotherapy were assessed using HPLC. The highest CBZ and CBZ-E level to dose ratios were observed in the RBC. For CBZ and CBZ-E significant correlations were found between some blood compartments particularly between RBC and plasma ultrafiltrate. The measurement of CBZ and CBZ-E in all blood compartments may be interesting in uncontrolled patients and in patients presenting side-effects which cannot be explained by total plasma concentration values.
authors.affiliation: U 278 INSERM Faculte de Pharmacie, Marseille, France.
authors.forename: J
authors.initials: J
authors.lastname: Bonneton
authors.forename: P
authors.initials: P
authors.lastname: Genton
authors.forename: E
authors.initials: E
authors.lastname: Mesdjian
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D002220:Carbamazepine / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D004827:Epilepsy / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D014462:Ultrafiltration
chemical_list: D001798:Blood Proteins; D002220:Carbamazepine; C012227:carbamazepine epoxide