Lipid and apolipoprotein changes after orthotopic liver transplantation for end-stage liver diseases.
Orthotopic liver transplantation was performed in 37 patients with different endstage liver diseases. Changes in lipid and apolipoprotein concentrations were followed daily from day 1 to 20 after surgery and regularly thereafter until 12 months. When the acute effects of surgery had cleared away, there was a sharp drop in HDL-C, apo A-I and A-II from day 1 to 5, a stabilization at their lowest values from day 5 to 15 and then a progressive rise. Contrasting with this drop, triglycerides, apo B, C-II and C-III increased from day 1 to 5 with variable concentrations thereafter. Apo SAA considerably increased early after surgery and remained significantly higher than normal in most patients after 12 months. All other parameters returned to normal from 3 to 6 months after transplant. The mechanism leading to these lipid and apolipoprotein changes are discussed with respect to the distant effect of infusions, re-alimentation, immunosuppressive therapy and lipoprotein metabolism. The apolipoprotein concentrations appear very useful indicators of functional liver recovery.
Malmendier
C L
CL
Fondation de Recherche sur l'Athérosclérose, Brussels, Belgium.
Lontie
J F
JF
Mathé
D
D
Adam
R
R
Bismuth
H
H
D000328:Adult; D001053:Apolipoproteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000601:surgery*; D050356:Lipid Metabolism; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged
D001053:Apolipoproteins