title: A serine, threonine and proline-rich region near the carboxyl-terminus of a rat intestinal mucin peptide.
abstract: Further sequencing of a cDNA encoding the C-terminal region of a rat intestinal mucin peptide reveals a region corresponding to 258 amino acids enriched in serine, threonine and proline, but no typical mucin-like tandem repeat structures. Between this region and a previously described stretch of 4.5 degenerate S,T,P-rich tandem repeats, there is a 42 amino acid cysteine-rich segment. The discontinuity of cysteine-rich and S,T,P-rich areas near the C-terminus has not been observed in other mammalian mucin structures reported to date.
authors.affiliation: Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: L J
authors.initials: LJ
authors.lastname: Huan
authors.forename: G
authors.initials: G
authors.lastname: Xu
authors.forename: G
authors.initials: G
authors.lastname: Forstner
authors.forename: J
authors.initials: J
authors.lastname: Forstner
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D007413:Intestinal Mucosa / Q000502:physiology*; D008969:Molecular Sequence Data; D009077:Mucins / Q000235:genetics*; D011392:Proline; D012313:RNA / Q000235:genetics / Q000302:isolation & purification; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D012091:Repetitive Sequences, Nucleic Acid; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D012694:Serine; D013912:Threonine
chemical_list: D009077:Mucins; D012333:RNA, Messenger; C076410:mucin-like peptide 3500; D013912:Threonine; D012694:Serine; D012313:RNA; D004247:DNA; D011392:Proline