title: Comparison of MRI white matter changes with neuropsychologic impairment in Cockayne syndrome.
abstract: The neuropsychologic function and white matter changes observed on magnetic resonance imaging (MRI) in Cockayne syndrome were studied. MRI with T2-weighted sequences revealed periventricular hyperintensity and white matter hyperintensity in all 3 Cockayne syndrome patients examined; in contrast, 8 age-matched controls had no periventricular or white matter hyperintensity. MRI scans were graded according to the severity of periventricular or white matter hyperintensity using a scale applied to an elderly patient population. There was no difference in the severity of MRI white matter changes in these 3 Cockayne syndrome patients, 2 of whom had severe neuropsychologic functions and one a relatively milder one. There was no correlation between neuropsychologic impairment and MRI white matter changes.
authors.affiliation: Department of Pediatrics, Chiba University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sugita
authors.forename: J
authors.initials: J
authors.lastname: Takanashi
authors.forename: M
authors.initials: M
authors.lastname: Ishii
authors.forename: H
authors.initials: H
authors.lastname: Niimi
mesh_terms: D000293:Adolescent; D001921:Brain / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology; D002552:Cerebral Ventricles / Q000473:pathology; D002648:Child; D003057:Cockayne Syndrome / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009186:Myelin Sheath / Q000473:pathology; D009460:Neurologic Examination; D009483:Neuropsychological Tests