title: Undifferentiated small cell hepatoblastoma with a unique chromosomal translocation: a case report.
abstract: Cytogenetic studies of pediatric tumors have revealed a number of reproducible karyotypic abnormalities, including del(p13) found in aniridia-Wilms' tumor association, t(8;14) in Burkitt's lymphoma, and t(11;22) in Ewing's sarcoma. To date, no consistent cytogenetic abnormality has been reported in association with hepatoblastoma. We report the case of a 7-month-old male infant with the undifferentiated small cell variant of hepatoblastoma. Immunohistochemistry revealed reactivity with antibodies to cytokeratin and vimentin throughout the tumor. Alpha-fetoprotein, neuron-specific enolase, and S100 stains were negative. Chromosomal analysis of metaphase cells from a culture of tumor tissue revealed a translocation of most of the long arm of chromosome 22 to the distal long arm of chromosome 10.
authors.affiliation: Department of Pathology, Rhode Island Hospital, Providence 02903.
authors.forename: K
authors.initials: K
authors.lastname: Hansen
authors.forename: J
authors.initials: J
authors.lastname: Bagtas
authors.forename: H F
authors.initials: HF
authors.lastname: Mark
authors.forename: A
authors.initials: A
authors.lastname: Homans
authors.forename: D B
authors.initials: DB
authors.lastname: Singer
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002454:Cell Differentiation; D002879:Chromosomes, Human, Pair 10; D002892:Chromosomes, Human, Pair 22; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007633:Keratins / Q000378:metabolism; D008113:Liver Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008297:Male; D014178:Translocation, Genetic; D014746:Vimentin / Q000378:metabolism
chemical_list: D014746:Vimentin; D007633:Keratins