title: Comparison of inorganic bovine bone mineral particles with porous hydroxyapatite granules and cranial bone dust in the reconstruction of full-thickness skull defect.
abstract: Twenty adult rabbits were used to evaluate the biocompatibility and osteoconductivity of Bio-Oss, an inorganic bovine bone mineral, in the reconstruction of full-thickness skull defects. Skull defects were treated with either autogenous bone dust, porous hydroxyapatite granules, Bio-Oss particles, or were left untreated as controls. Histological examination of decalcified sections showed incorporation of Bio-Oss into the host tissue without a significant inflammatory reaction. Measurement of the profile area occupied by the bone revealed that Bio-Oss, hydroxyapatite, and the control had the same amount of bone ingrowth, whereas autogenous bone dust produced a greater amount of bone (p < 0.01). We conclude that Bio-Oss, like porous hydroxyapatite, has sufficient osteoconductive properties and can also be used as a bone substitute material.
authors.affiliation: Providence Hospital, Southfield, MI.
authors.forename: K
authors.initials: K
authors.lastname: Fukuta
authors.forename: Y
authors.initials: Y
authors.lastname: Har-Shai
authors.forename: M V
authors.initials: MV
authors.lastname: Collares
authors.forename: J B
authors.initials: JB
authors.lastname: Lichten
authors.forename: I T
authors.initials: IT
authors.lastname: Jackson
mesh_terms: D000818:Animals; D001031:Apatites; D001672:Biocompatible Materials; D016025:Bone Transplantation / Q000379:methods*; D001842:Bone and Bones; D002417:Cattle; D006882:Hydroxyapatites; D008422:Materials Testing; D008903:Minerals; D010012:Osteogenesis; D011817:Rabbits; D012886:Skull / Q000601:surgery*
chemical_list: D001031:Apatites; C077540:Bio-Oss; D001672:Biocompatible Materials; D006882:Hydroxyapatites; D008903:Minerals