The uptake of anionic and cationic amino acids by the isolated perfused sheep choroid plexus.
The carrier-mediated uptake of anionic and cationic amino acids by the basolateral face (blood side) of the isolated perfused sheep choroid plexus was demonstrated using the paired-tracer dilution technique. The uptake of these two classes of amino acid was higher than at the blood-brain barrier with no cross-competition between them. In addition the uptake was markedly stereospecific with a high degree of selectivity and no interaction with the L-system amino acids.
Preston
J E
JE
Sherrington School of Physiology, United Medical School, Guy's Hospital, London, UK.
Segal
M B
MB
D000818:Animals; D001120:Arginine / Q000378:metabolism*; D001224:Aspartic Acid / Q000378:metabolism*; D001692:Biological Transport / Q000187:drug effects; D002831:Choroid Plexus / Q000378:metabolism*; D005260:Female; D005971:Glutamates / Q000378:metabolism* / Q000494:pharmacology; D066298:In Vitro Techniques; D007700:Kinetics; D008239:Lysine / Q000378:metabolism* / Q000494:pharmacology; D008297:Male; D010477:Perfusion; D012756:Sheep
D005971:Glutamates; D001224:Aspartic Acid; D001120:Arginine; D008239:Lysine