RNA kinetics at the wound margins.
The in vitro incorporation rate of 3H cytidine was determined by autoradiography in vital specimens taken from cut wounds in the outer ear of rats and evaluated by means of a Quantimet 920. Seven rats in each group were allowed to survive for the same periods of time between 0 and 60 hours. The following findings were observed: after 10 hours survival time the cytidine incorporation rate in the basal cells increased significantly, while remaining unchanged in all other skin layers. The relationship between the higher RNA synthesis rate and the increase in DNA synthesis--particularly in the basal cell layer--is discussed.
Oehmichen
M
M
Institut für Rechtsmedizin, Medizinische Universität zu Lübeck, Deutschland.
Lagodka
T
T
D000818:Animals; D001485:Basement Membrane / Q000378:metabolism; D005260:Female; D012313:RNA / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000378:metabolism*; D013997:Time Factors; D014945:Wound Healing
D012313:RNA