title: An immunohistochemical study on HLA-DR expression in human meningiomas.
abstract: The expression of HLA-DR was examined in 38 cases of meningiomas with the streptavidin-biotin immunoperoxidase method using two monoclonal antibodies to HLA-DR (LN-3 and TAL-IB5) on formalin-fixed, paraffin-embedded specimens. Similar immunoreactivity was obtained with these two monoclonal antibodies. In addition to infiltrated lymphoid cells and perivascular macrophages, tumor cells themselves showed HLA-DR expression in 16 cases (42%) of meningiomas. The rate of HLA-DR-positive cases in the transitional and fibrous subtypes (64% and 67%, respectively) was higher than that in the meningotheliomatous subtype (8%). Spindle-shaped tumor cells were frequently positive for HLA-DR, whereas few of meningotheliomatous cells with plump cytoplasm were positive. Most of HLA-DR-positive cases showed no or scanty lymphoid cell infiltration, and a few cases with marked infiltration of lymphoid cells were variable for HLA-DR expression. These findings suggest little correlation between HLA-DR expression of tumor cells and the degree of lymphoid cell infiltration, but indicate an aberrant HLA-DR expression of tumor cells themselves.
authors.affiliation: Second Department of Pathology, Okayama University Medical School, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Ohara
authors.forename: K
authors.initials: K
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Miyake
authors.forename: H J
authors.initials: HJ
authors.lastname: Jeon
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Akagi
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008577:Meningeal Neoplasms / Q000276:immunology* / Q000473:pathology; D008579:Meningioma / Q000276:immunology* / Q000473:pathology; D008875:Middle Aged; D013194:Staining and Labeling
chemical_list: D006684:HLA-DR Antigens