[Development of oral vaccines based on recombinant proteins derived from cholera toxin].
In this paper a new approach to create antigens through genetic engineering is discussed. In this particular case the subunits of V. cholerae toxin are used as heterologous epitope carries. In this paper the manipulation of A and B subunits is described. This manipulation allows both the insertion of epitopes to the B subunit and the use of subunit A in the construction of recombinant antigens similar to the ones derived from subunit B.
Sánchez
J
J
Centro de Investigaciones sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México.
Solórzano
R M
RM
D000284:Administration, Oral; D001428:Bacterial Vaccines / Q000008:administration & dosage; D002772:Cholera Toxin / Q000235:genetics; D000939:Epitopes; D005818:Genetic Engineering; D011994:Recombinant Proteins; D014734:Vibrio cholerae / Q000235:genetics
D001428:Bacterial Vaccines; D000939:Epitopes; D011994:Recombinant Proteins; D002772:Cholera Toxin