title: Demonstration of mismatch negativity in the monkey.
abstract: In humans, deviant auditory stimuli elicit an event-related potential (ERP) component, termed "mismatch negativity" (MMN), that reflects the operation of a cortical detector of infrequent stimulus change. Epidural auditory ERPs were recorded from 3 cynomolgous monkeys in response to soft and loud clicks. "Oddball" loud or soft stimuli elicited a long-duration frontocentral negativity, peaking at approximately 85 msec, that was superimposed upon cortically generated obligatory ERP components. These data suggest that monkeys might serve as a heuristically valuable system in which to study the neurochemical and neuroanatomical substrates of early context-dependent ERP generation.
authors.affiliation: Department of Psychiatry, Albert Einstein College of Medicine, Bronx, NY 10461.
authors.forename: D C
authors.initials: DC
authors.lastname: Javitt
authors.forename: C E
authors.initials: CE
authors.lastname: Schroeder
authors.forename: M
authors.initials: M
authors.lastname: Steinschneider
authors.forename: J C
authors.initials: JC
authors.lastname: Arezzo
authors.forename: H G
authors.initials: HG
authors.lastname: Vaughan
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001921:Brain / Q000502:physiology*; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D008252:Macaca fascicularis; D008297:Male; D011930:Reaction Time / Q000502:physiology