title: Captopril-induced pemphigus vegetans with Charcot-Leyden crystals.
abstract: A 78-year-old woman developed intertriginous vegetating plaques, mouth ulcers, and a cerebriform tongue after 11 months of captopril therapy. Findings of clinical, histologic, and immunofluorescence testing were consistent with a diagnosis of pemphigus vegetans. In addition, Charcot-Leyden crystals were observed within some of the intraepidermal, eosinophilic abscess cavities, which were bordered by granular cells undergoing keratinization. The skin lesions cleared rapidly after discontinuation of captopril. To the best of our knowledge, this report describes the first case of pemphigus vegetans induced by captopril.
authors.affiliation: Department of Dermatology, Curry Cabral Hospital, Lisboa, Portugal.
authors.forename: G M
authors.initials: GM
authors.lastname: Pinto
authors.forename: P
authors.initials: P
authors.lastname: Lamarão
authors.forename: T
authors.initials: T
authors.lastname: Vale
mesh_terms: D000368:Aged; D002216:Captopril / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D004804:Eosinophils / Q000378:metabolism; D005260:Female; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D008245:Lysophospholipase; D010392:Pemphigus / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology
chemical_list: D006023:Glycoproteins; D002216:Captopril; D008245:Lysophospholipase; C011711:lysolecithin acylhydrolase