[Antifibrosis effect of modified forms of catalase and superoxide dismutase in experimental silicosis].
The forms of catalase modified by treatment with dextran aldehyde were obtained and studied. Efficacy of the preparations containing native and modified forms of catalase and superoxide dismutase as well as their covalent bienzyme conjugate containing catalase-dextran aldehyde-superoxide dismutase was studied in rats with simulated silicosis. The preparations were administered into rats by means of inhalation and intraperitoneal injection. Positive protective effect exhibited a mixture of native enzymes and their covalent conjugate. The most pronounced additional effect was caused by the mixture of native catalase and superoxide dismutase as compared with modified preparation of superoxide dismutase. The preparation of bienzyme containing conjugate was less effective.
Maksimenko
A V
AV
Bezrukavnikova
L M
LM
Grigor'eva
E L
EL
Tishchenko
E G
EG
Arkhipova
O G
OG
Iaglov
V V
VV
Torchilin
V P
VP
D000818:Animals; D002374:Catalase / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D002417:Cattle; D002850:Chromatography, Gel; D003911:Dextrans / Q000737:chemistry; D008099:Liver / Q000201:enzymology; D011658:Pulmonary Fibrosis / Q000188:drug therapy*; D051381:Rats; D012829:Silicosis / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*
D003911:Dextrans; D002374:Catalase; D013482:Superoxide Dismutase