The influence of vancomycin concentration and the pH of plasma on vancomycin protein binding.
A review of numerous studies of the protein binding of vancomycin suggests major discrepancies among their results. The reported percent protein binding of vancomycin varies from 0% to 98%. The influence of pH and concentration on the protein binding of vancomycin was investigated in this study. There was a significant difference (p < 0.001) in percent protein binding in vancomycin-spiked plasma samples across the pH range of 7.0-8.0. There was no significant difference (p > 0.05) in percent protein binding in vancomycin-spiked plasma samples across the concentration range of 2-80 mg/L. It is likely that some of the variation reported to date may be due to a lack of control of pH during the measurement of protein binding of vancomycin.
Chen
Y
Y
Department of Clinical Pharmacology, Princess Alexandra Hospital, Woolloongabba QLD, Australia.
Norris
R L
RL
Schneider
J J
JJ
Ravenscroft
P J
PJ
D001798:Blood Proteins / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D011485:Protein Binding / Q000187:drug effects; D014640:Vancomycin / Q000378:metabolism*
D001798:Blood Proteins; D014640:Vancomycin