X-linked dystrophies: from gene localization to gene therapy.
Linkage studies have narrowed the interval to which the Emery-Dreifuss muscular dystrophy (EDMD) gene maps, raising prospects for isolating this locus. Diagnosis and carrier detection for Duchenne muscular dystrophy (DMD) have been improved, new isoforms of dystrophin have been identified, and gene transfer studies have raised the prospects for gene therapy.
Chamberlain
J S
JS
Department of Human Genetics, University of Michigan Medical School, Ann Arbor.
D016189:Dystrophin / Q000235:genetics; D006580:Genetic Carrier Screening; D008040:Genetic Linkage / Q000235:genetics*; D015316:Genetic Therapy; D006801:Humans; D009136:Muscular Dystrophies / Q000235:genetics*; D012729:Sex Chromosome Aberrations / Q000235:genetics*; D014960:X Chromosome
D016189:Dystrophin