title: The cultured diploid fibroblast as a model for the study of cellular aging.
abstract: The limited proliferative potential of the cultured human diploid fibroblast is now well established. A number of biological correlates suggest that this culture system is a model for the study of aging at the cellular level. The mechanism(s) that causes the loss of proliferative activity is unknown; the results of some recent studies indicate that specific genes may play a pivotal role in cellular aging in vitro. The extent to which changes in proliferative functions are causally related to aging in vivo is currently under investigation.
authors.affiliation: Department of Pathology, University of Washington, Seattle 98195.
authors.forename: T H
authors.initials: TH
authors.lastname: Norwood
authors.forename: W R
authors.initials: WR
authors.lastname: Pendergrass
mesh_terms: D002478:Cells, Cultured; D016922:Cellular Senescence / Q000502:physiology*; D004171:Diploidy; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology*; D006801:Humans; D008954:Models, Biological