title: Co-transplantation of fetal or adult dorsal root ganglia and of autologous peripheral nerve segments to the adult rat spinal cord: extensive reinnervation of the grafted nerves by the transplanted DRG cells.
abstract: Intraspinal transplantation of embryonic neurons and of autologous peripheral nerve segments is an essential tool for studying plasticity and repair in the adult mammalian spinal cord. Unlike adult central nervous system neurons, adult dorsal root ganglion (DRG) cells can be cultured in vitro and are assumed to survive transplantation. In the present work, we have co-transplanted adult (and also fetal, for comparison) DRG and peripheral nerve autografts to the cervical spinal cord of the adult rat. Similar results were obtained from both series: fetal as well as adult DRG cells did survive transplantation and nearly half of them grew lengthy axons into the grafted nerves. A few of them were seen to express a calcitonin gene-related peptide. Possibilities of central afferentation as well as of peripheral connectivity of these transplanted neurons is under study.
authors.affiliation: Laboratoire de Neurobiologie, Université René Descartes, Paris, France.
authors.forename: J H
authors.initials: JH
authors.lastname: Ye
authors.forename: F
authors.initials: F
authors.lastname: Rhrich
authors.forename: C
authors.initials: C
authors.lastname: Baillet-Derbin
authors.forename: J C
authors.initials: JC
authors.lastname: Horvat
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism; D005260:Female; D016332:Fetal Tissue Transplantation; D005727:Ganglia, Spinal / Q000166:cytology / Q000502:physiology*; D006085:Graft Survival; D009416:Nerve Regeneration; D009417:Nerve Tissue / Q000637:transplantation*; D010525:Peripheral Nerves / Q000502:physiology / Q000637:transplantation*; D051381:Rats; D013116:Spinal Cord / Q000502:physiology*; D014182:Transplantation, Autologous
chemical_list: D015740:Calcitonin Gene-Related Peptide