Chronic administration of cyclosporin A induces a decrease in hepatic excretory function in man.
Chronic administration of cyclosporin A may induce cholestasis in a few patients. The purpose of this study was to examine the effect of chronic administration of cyclosporin A on serum bile acid levels, serum bilirubin concentration, and bromosulfophthalein plasmatic fractional clearance. Twenty heart-transplanted patients with normal serum alanine aminotransferase activity receiving cyclosporine A during a mean duration of 33 months (range 7-54) were compared to 20 matched kidney-transplanted patients with normal serum alanine aminotransferase receiving azathioprine for a mean duration of 34 months (range 6-72). As compared to azathioprine-treated patients, patients treated with cyclosporin A had an increase in serum bile acid levels of 32% (P < 0.01), an increase in serum bilirubin concentration of 100% (P < 0.001), and a decrease in bromosulfophthalein plasmatic fractional clearance of 60% (P < 0.001). These results suggest that cyclosporin A induces a decrease in hepatic excretory function in man.
Cadranel
J F
JF
Service d'Hépatogastroentérologie, Hôpital de la Pitié-Salpétrière, Paris, France.
Erlinger
S
S
Desruenne
M
M
Luciani
J
J
Lunel
F
F
Grippon
P
P
Cabrol
A
A
Opolon
P
P
D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001379:Azathioprine / Q000494:pharmacology; D001647:Bile Acids and Salts / Q000097:blood*; D001663:Bilirubin / Q000097:blood*; D016572:Cyclosporine / Q000008:administration & dosage*; D005215:Fasting; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013448:Sulfobromophthalein / Q000378:metabolism*
D001647:Bile Acids and Salts; D013448:Sulfobromophthalein; D016572:Cyclosporine; D000410:Alanine Transaminase; D001379:Azathioprine; D001663:Bilirubin