Deletions of 17p and p53 mutations in preneoplastic lesions of the lung.
Cytogenetic and p53 mutation analysis in two cases of severe dysplasia of the bronchial epithelium in lung cancer patients and p53 immunostaining in a third one are reported. The finding of both chromosomal deletions of 17p and p53 mutation indicates that these changes may take place early in the process of lung carcinogenesis.
Sozzi
G
G
Division of Experimental Oncology A, Istituto Nazionale Tumori, Milano, Italy.
Miozzo
M
M
Donghi
R
R
Pilotti
S
S
Cariani
C T
CT
Pastorino
U
U
Della Porta
G
G
Pierotti
M A
MA
D001483:Base Sequence; D002278:Carcinoma in Situ / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002872:Chromosome Deletion; D002886:Chromosomes, Human, Pair 17; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008969:Molecular Sequence Data; D011230:Precancerous Conditions / Q000235:genetics*