title: [Enteropathogenicity and enteropathogenic toxin production of Vibrio mimicus].
abstract: Enteropathogenicity and enteroreactive-toxins were examined in 66 strains of Vibrio mimicus and the following results were obtained. Frequencies of enteropathogenic strains judged by the result of suckling mouse tests were 11/13 (85%) for clinical isolates and 37/53 (70%) for fish or environmental isolates. Frequencies of preservation of cholera toxin gene and NAG-ST gene were 2 and 15%, respectively, for 48 enteropathogenic strains, and 0 and 6%, respectively, for 18 non-enteropathogenic strains. Frequencies of production of NAG-rTDH, FAF and hemolysin were 4, 63 and 100%, respectively, for 48 enteropathogenic strains, and 6, 50, and 100%, respectively, for 18 non-enteropathogenic strains. No correlation between serovar and enteropathogenicity was observed in the suckling mouse test. Six out of 12 enteropathogenic strains produced hemolysin in ligated rabbit ileal loop, while 1 out of 12 non-enteropathogenic strains did so under the same condition. A significant inhibition of fluid accumulation in the ligated rabbit ileal loop test with viable cells was noted in rabbits immunized with hemolysin of non-O1 V. cholerae. These results suggest that approximately two-thirds of environmental isolates are enteropathogenic and that hemolysin is the most important toxin in the enteropathogenic mechanism of V. mimicus strains.
authors.affiliation: Toyama Institute of Health.
authors.forename: Y
authors.initials: Y
authors.lastname: Gyobu
authors.forename: J
authors.initials: J
authors.lastname: Isobe
authors.forename: H
authors.initials: H
authors.lastname: Kodama
authors.forename: S
authors.initials: S
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Shimada
mesh_terms: D000818:Animals; D003967:Diarrhea / Q000382:microbiology / Q000401:mortality; D004768:Enterotoxins / Q000096:biosynthesis*; D051379:Mice; D011817:Rabbits; D014733:Vibrio / Q000302:isolation & purification / Q000378:metabolism / Q000472:pathogenicity*
chemical_list: D004768:Enterotoxins; C069211:enterotoxin, Vibrio mimicus