Loss of heterozygosity for 10q loci in human gliomas.
Cytogenetic and RFLP studies have shown that chromosome 10 is frequently lost in tumor cells from glioblastomas, suggesting that a suppressor gene important in tumorigenesis is present on this chromosome. Forty-one tumors were examined for loss of heterozygosity at 23 loci on chromosome 10 to determine the smallest common deletion interval on this chromosome. Seven tumors did not lose heterozygosity for any of the markers. Twenty-three tumors lost an allele for all the informative loci. In 11 tumors heterozygosity was maintained at some loci and lost at other loci, indicating partial deletion of chromosome 10. The common region of deletion in these 11 tumors was located in 10q24-q26 between the markers pHUK-8 and pMCT122.2.
Rasheed
B K
BK
Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710.
Fuller
G N
GN
Friedman
A H
AH
Bigner
D D
DD
Bigner
S H
SH
D000483:Alleles; D001932:Brain Neoplasms / Q000235:genetics*; D002872:Chromosome Deletion; D002879:Chromosomes, Human, Pair 10 / Q000648:ultrastructure*; D015342:DNA Probes; D005260:Female; D005819:Genetic Markers; D005909:Glioblastoma / Q000235:genetics; D005910:Glioma / Q000235:genetics*; D006801:Humans; D008297:Male; D012150:Polymorphism, Restriction Fragment Length
D015342:DNA Probes; D005819:Genetic Markers