title: Loss of chromosome 3 alleles and multiplication of chromosome 8 alleles in uveal melanoma.
abstract: Uveal melanoma is the most frequent primary intraocular tumor. The etiology is unknown. Using neutral DNA polymorphisms on chromosomes 2, 3, and 8, we have detected loss of chromosome 3 alleles in 8 of 13 tumors and multiplication of chromosome 8 alleles in 6 of 11 tumors. No anomalies at a locus on chromosome 2 were found in 10 of 10 tumors. These results confirm and extend previous cytogenetic findings and suggest that a tumor suppressor gene on chromosome 3 and an oncogene on chromosome 8 may be involved in the formation or progression of this tumor.
authors.affiliation: Institut für Humangenetik, Universitätsklinikum Essen, Federal Republic of Germany.
authors.forename: B
authors.initials: B
authors.lastname: Horsthemke
authors.forename: G
authors.initials: G
authors.lastname: Prescher
authors.forename: N
authors.initials: N
authors.lastname: Bornfeld
authors.forename: R
authors.initials: R
authors.lastname: Becher
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D014408:Biomarkers, Tumor; D015139:Blotting, Southern; D002872:Chromosome Deletion; D002893:Chromosomes, Human, Pair 3; D002898:Chromosomes, Human, Pair 8; D004247:DNA / Q000032:analysis; D003720:Densitometry; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008545:Melanoma / Q000235:genetics*; D008875:Middle Aged; D005810:Multigene Family; D011110:Polymorphism, Genetic; D014604:Uveal Neoplasms / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D004247:DNA