Cytogenetic analysis of a uterine lipoleiomyoma.
We cytogenetically analyzed a uterine lipoleiomyoma. A primary chromosomal abnormality, t(12;14), was found in all 62 cells studied. A secondary change involving chromosomes 1 and 5 was detected in 15 of 62 cells. These findings suggest that lipoleiomyomas share the same chromosomal abnormalities found in common leiomyomas. We speculate that the secondary chromosomal change involving chromosomal 5 may be responsible for the lipomatous change.
Hu
J
J
Department of Human Genetics, University of Pittsburgh, Pennsylvania.
Surti
U
U
Tobon
H
H
D002878:Chromosomes, Human, Pair 1; D002881:Chromosomes, Human, Pair 12; D002884:Chromosomes, Human, Pair 15; D002895:Chromosomes, Human, Pair 5; D005260:Female; D006801:Humans; D007621:Karyotyping; D007889:Leiomyoma / Q000235:genetics* / Q000473:pathology; D008067:Lipoma / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D014178:Translocation, Genetic; D014594:Uterine Neoplasms / Q000235:genetics* / Q000473:pathology