title: Cerebrospinal fluid biogenic amine metabolites in fibromyalgia/fibrositis syndrome and rheumatoid arthritis.
abstract: OBJECTIVE
  To compare the levels of biogenic amines in the cerebrospinal fluid (CSF) of primary fibromyalgia syndrome (PFS) patients with those in the CSF of controls.
  
  
  METHODS
  Metabolites of serotonin, norepinephrine, and dopamine were identified in CSF, using high performance liquid chromatography with coulometric detection.
  
  
  RESULTS
  CSF levels of metabolites from all 3 neurotransmitters were lower in PFS patients than in controls.
  
  
  CONCLUSIONS
  A low rate of turnover of several neurotransmitters supports the proposed hypothesis of a metabolic defect in PFS and suggests that the defect occurs at a neuroregulatory level.
authors.affiliation: Department of Medicine, University of Texas Health Science Center, San Antonio 78284-7874.
authors.forename: I J
authors.initials: IJ
authors.lastname: Russell
authors.forename: H
authors.initials: H
authors.lastname: Vaeroy
authors.forename: M
authors.initials: M
authors.lastname: Javors
authors.forename: F
authors.initials: F
authors.lastname: Nyberg
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000134:cerebrospinal fluid*; D001679:Biogenic Amines / Q000134:cerebrospinal fluid*; D005260:Female; D005356:Fibromyalgia / Q000134:cerebrospinal fluid*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D013577:Syndrome
chemical_list: D001679:Biogenic Amines; D006897:Hydroxyindoleacetic Acid