Lp(a) and the risk of coronary heart disease.
A screening study was performed on 106 children with familial risk for coronary heart disease (CHD) and on matched controls. The two groups differed in several parameters. Children of CHD patients exhibited significantly elevated levels of Lp(a) and total cholesterol, reduced HDL apo A1 and apo A2 and increased values of serum hexuronic acid. These results support the concept that genetic and familial factors contribute to the risk of atherosclerosis.
Bihari-Varga
M
M
2nd Dept. of Pathology, Semmelweis University, Budapest, Hungary.
Kostner
G
G
Czinner
A
A
D000293:Adolescent; D000367:Age Factors; D016632:Apolipoprotein A-I / Q000032:analysis*; D016633:Apolipoprotein A-II / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D003327:Coronary Disease / Q000209:etiology* / Q000235:genetics; D004198:Disease Susceptibility; D006025:Glycosaminoglycans / Q000097:blood; D006801:Humans; D006951:Hyperlipoproteinemias / Q000150:complications* / Q000235:genetics; D007009:Hypolipoproteinemias / Q000150:complications* / Q000235:genetics; D017270:Lipoprotein(a); D008074:Lipoproteins / Q000097:blood* / Q000235:genetics; D008075:Lipoproteins, HDL / Q000097:blood*; D012307:Risk Factors
D016632:Apolipoprotein A-I; D016633:Apolipoprotein A-II; D006025:Glycosaminoglycans; D017270:Lipoprotein(a); D008074:Lipoproteins; D008075:Lipoproteins, HDL