title: Recombinant factor VIIa in an infant with haemophilia A and inhibitors.
abstract: Post-traumatic bleeding from the gingiva in a 16-month-old boy with severe haemophilia A did not stop after treatment with factor VIII concentrate and tranexamic acid, and it was demonstrated that he had developed antibodies to factor VIII. Treatment with recombinant factor VIIa 60-90 micrograms/kg body weight four to eight times daily, together with local measures, stopped the bleeding and no complications were seen.
authors.affiliation: Section of Coagulation Disorders, Sahlgren's Hospital, Göteborg, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Tengborn
authors.forename: B
authors.initials: B
authors.lastname: Kjellman
authors.forename: P O
authors.initials: PO
authors.lastname: Elfstrand
authors.forename: T
authors.initials: T
authors.lastname: Bågenholm
mesh_terms: D005169:Factor VIII / Q000276:immunology*; D015942:Factor VIIa / Q000627:therapeutic use*; D006467:Hemophilia A / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007223:Infant; D007518:Isoantibodies; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D007518:Isoantibodies; D011994:Recombinant Proteins; D005169:Factor VIII; D015942:Factor VIIa