title: Streptokinase morbidity--more common than previously recognised.
abstract: Streptokinase is the thrombolytic agent most commonly used for the treatment of acute myocardial infarction. We report eight patients who developed late uncommon adverse reactions to streptokinase probably due to immune complex disease. The clinical manifestations included vasculitic rashes, abnormal renal and liver function tests and a syndrome resembling adult respiratory distress syndrome. Major adverse events with streptokinase such as stroke, bleeding and other allergic reactions, have been previously documented but the morbidity related to delayed reactions has not been widely recognised. These reactions produced significant morbidity resulting in prolonged hospital stay and may need to be considered in the decision to use streptokinase.
authors.affiliation: Department of Pharmacy, Flinders Medical Centre, Adelaide, SA.
authors.forename: W J
authors.initials: WJ
authors.lastname: Siebert
authors.forename: R W
authors.initials: RW
authors.lastname: Ayres
authors.forename: M T
authors.initials: MT
authors.lastname: Bulling
authors.forename: C M
authors.initials: CM
authors.lastname: Thomas
authors.forename: R B
authors.initials: RB
authors.lastname: Minson
authors.forename: P E
authors.initials: PE
authors.lastname: Aylward
mesh_terms: D000328:Adult; D000368:Aged; D004342:Drug Hypersensitivity / Q000209:etiology*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced / Q000276:immunology; D007105:Immune Complex Diseases / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy; D013300:Streptokinase / Q000009:adverse effects* / Q000276:immunology
chemical_list: D013300:Streptokinase