Cyclin D1 messenger RNA is inducible by platelet-derived growth factor in cultured fibroblasts.
In fibroblasts in culture, the levels of cyclin D1 mRNA are growth regulated. In mouse and in human fibroblasts, both serum and platelet-derived growth factor increase cyclin D1 mRNA levels with similar kinetics of induction. Insulin-like growth factor 1 by itself does not induce cyclin D1 expression, and an antisense oligodeoxynucleotide to the insulin-like growth factor 1 receptor RNA does not affect the growth-regulated levels of cyclin D1 mRNA.
Surmacz
E
E
Jefferson Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107-5541.
Reiss
K
K
Sell
C
C
Baserga
R
R
D016475:3T3 Cells / Q000378:metabolism; D000818:Animals; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics / Q000494:pharmacology*; D016213:Cyclins / Q000096:biosynthesis*; D005347:Fibroblasts / Q000378:metabolism*; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008969:Molecular Sequence Data; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology*; D016133:Polymerase Chain Reaction / Q000379:methods; D012333:RNA, Messenger / Q000096:biosynthesis*; D016192:Resting Phase, Cell Cycle; D014407:Tumor Cells, Cultured
D002352:Carrier Proteins; D016213:Cyclins; D018970:Insulin-Like Growth Factor Binding Protein 1; D010982:Platelet-Derived Growth Factor; D012333:RNA, Messenger