Dietary iron loading does not influence biliary iron excretion in rats.
The effect of dietary iron loading on biliary iron excretion was investigated with male Wistar rats aged 6 wk. The rats were fed purified diets with either 174 or 1740 mg FeSO4. 7H2O/kg diet and demineralized water for 6 wk. Blood haemoglobin, hematocrit, and iron concentrations in kidney and heart were not affected and iron concentrations in liver, spleen, and tibia were significantly raised after feeding the high-iron diet. The high-iron diet did not raise biliary iron excretion, suggesting that biliary iron excretion does not play an important role in regulating iron metabolism in rat after dietary iron loading.
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Department of Large Animal Medicine and Nutrition, State University, Utrecht, The Netherlands.
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D000818:Animals; D001646:Bile / Q000378:metabolism*; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D007501:Iron / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism / Q000494:pharmacology*; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D008297:Male; D009206:Myocardium / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000737:chemistry; D013977:Tibia / Q000737:chemistry
D006454:Hemoglobins; D007501:Iron