[Roles of T cell subsets in the protective immunity of mice against Plasmodium yoelii].
BALB/c mice which had developed protective immunity against Plasmodium yoelii (P. y.) challenge were injected with anti-CD4 or anti-CD8 monoclonal antibody, and were then challenged again with P. yoelli. No impairment of protection was observed. CD8+T cells obtained from spleens of these mice were transferred to BALB/c nude mice and induced partial protection, while transfer of CD4+T cells did not so. In P. yoelli-mouse model, the parasites invaded reticulocytes in the early infection, and the infected reticulocytes could be recognized and attacked by sensitized CD8+T cells. In late infection when P. yoelli also invaded mature erythrocytes, the protective effect of CD8+T cells decreased and the main role of protection was played by antibodies.
Mao
Y H
YH
Institute of Basic Medical Sciences, CAMS, Beijing.
Fan
R G
RG
Liu
F X
FX
Su
W
W
Zhao
Z S
ZS
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D015704:CD4 Antigens / Q000276:immunology; D016827:CD8 Antigens / Q000276:immunology; D008288:Malaria / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D010967:Plasmodium yoelii / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000911:Antibodies, Monoclonal; D015704:CD4 Antigens; D016827:CD8 Antigens