Multiple fractions in the treatment of head and neck cancer.
Fifty-eight cases of head and neck cancer received hyperfractionated accelerated radiotherapy, with treatment three times daily to 47.5-54 Gy over 12-20 days. A total of 69% had a complete response within 3 months, and the actuarial survival was 52% at 1 year, 41% at 2 years, 43% at 3 years and 38% at 4 years. Acute reactions were rather more pronounced (31%) and late necrosis (15%) was more than would be expected with conventional fractionation. It is suggested that multiple fractions carried out by a small centre, are feasible and will reduce hospital stay.
Lindup
R
R
Radiotherapy Department, North Staffordshire Royal Infirmary, Stoke-on-Trent, UK.
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D008722:Methods; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D015996:Survival Rate