Humoral immunity in Down's syndrome.
Carried out on 57 outpatients, the study was aimed to prove the existence of a disgammaglobulinemia in Down's syndrome. The event could not be attributed to hospitalization. Data indicate increased A and G immunoglobulinemias. In agreement with other authors Ig A level was found to be very high especially after the age of 5. Ig M titre in patients was reduced in comparison with that of the controls, regardless of the age group. Increase timing of IgA and Ig G concentrations tends to be more marked for the Ig A fraction. In patients ranging from 0 to 5 years the Ig A serum level is deficient.
Bălăiţă
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Institute of Neurology and Psychiatry, Bucharest, Romania.
Christodorescu
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Gherghina
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Iscrulescu
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C
D000293:Adolescent; D000367:Age Factors; D000917:Antibody Formation / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000276:immunology*; D005260:Female; D006760:Hospitalization; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007136:Immunoglobulins / Q000032:analysis; D007223:Infant; D008297:Male
D007136:Immunoglobulins