title: Effects of butylated hydroxyanisole on ornithine decarboxylase activity induced by ultraviolet-B and PUVA in mouse skin.
abstract: The effects of butylated hydroxyanisole (BHA), a representative phenolic antioxidant, on the activity of ornithine decarboxylase (ODC, an indicator of tumor promotion and epidermal hyperproliferation) induced by ultraviolet-B (UVB) or PUVA in mouse skin were investigated. By topical application of BHA (55 mumol), PUVA-induced ODC activity was suppressed by about 60% at both 12 h and 24 h after treatment. In contrast, BHA failed to suppress UVB-induced ODC activity in mouse skin. These results suggest that the induction of ODC activity by UVB or PUVA is mediated by different pathways.
authors.affiliation: Department of Dermatology, Osaka City University Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kono
authors.forename: S
authors.initials: S
authors.lastname: Taniguchi
authors.forename: N
authors.initials: N
authors.lastname: Mizuno
authors.forename: M
authors.initials: M
authors.lastname: Fukuda
authors.forename: N
authors.initials: N
authors.lastname: Maekawa
authors.forename: T
authors.initials: T
authors.lastname: Hisa
authors.forename: M
authors.initials: M
authors.lastname: Ishii
authors.forename: S
authors.initials: S
authors.lastname: Otani
authors.forename: T
authors.initials: T
authors.lastname: Hamada
mesh_terms: D000818:Animals; D002083:Butylated Hydroxyanisole / Q000494:pharmacology*; D005260:Female; D051379:Mice; D008812:Mice, Hairless; D009955:Ornithine Decarboxylase / Q000378:metabolism* / Q000528:radiation effects; D011701:PUVA Therapy; D012867:Skin / Q000201:enzymology* / Q000528:radiation effects*; D014466:Ultraviolet Rays
chemical_list: D002083:Butylated Hydroxyanisole; D009955:Ornithine Decarboxylase