The genes for protamine 1 and 2 (PRM1 and PRM2) and transition protein 2 (TNP2) are closely linked in the mammalian genome.
The genes for two protamines (PRM1 and PRM2) and for two transition proteins (TNP1 and TNP2) have been characterized in several mammalian species. In the human, boar, and bull, the genes for PRM1, PRM2, and TNP2 are closely linked over a stretch of DNA 13-15 kb long. Although similar data are not yet available for the mouse and rat, our results suggest that the three genes are similarly linked in these species. The gene for TNP1 in all species studied is located on another chromosome.
Engel
W
W
Institut für Humangenetik der Universität, Göttingen, FRG.
Keime
S
S
Kremling
H
H
Hameister
H
H
Schlüter
G
G
D000818:Animals; D002868:Chromosomal Proteins, Non-Histone; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D003360:Cosmids; D004268:DNA-Binding Proteins; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology; D008040:Genetic Linkage; D016678:Genome; D015894:Genome, Human; D006801:Humans; D008677:Metaphase; D051379:Mice; D008815:Mice, Inbred Strains; D009687:Nuclear Proteins / Q000235:genetics*; D011479:Protamines / Q000235:genetics*
D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D011479:Protamines; C489505:Tnp2 protein, mouse; C489504:Tnp2 protein, rat; C053886:spermatid transition proteins