Shared antigenic epitopes of the major core proteins of human and simian immunodeficiency virus isolates.
Antigenic epitopes on the major core (gag) protein of isolates of simian and human immunodeficiency virus (SIV and HIV) were compared using a panel of eleven mouse monoclonal antibodies (Mabs) that recognized nine distinct gag epitopes. Viral isolates used for comparison were HIV-1IIIb, HIV-2ROD, and SIV isolates from macaque (SIVmac), sooty mangabey (SIVsm-UCD), African green monkey (SIVagm), and stump-tailed macaque (SIVstm-UCD). The relatedness of the various HIV and SIV isolates, as determined by Mabs to core protein epitopes, paralleled that ascertained by genetic sequencing.
Higgins
J R
JR
Department of Medicine, School of Veterinary Medicine, University of California, Davis 95616.
Sutjipto
S
S
Marx
P A
PA
Pedersen
N C
NC
D000911:Antibodies, Monoclonal; D000939:Epitopes / Q000276:immunology*; D015683:Gene Products, gag / Q000276:immunology*; D006678:HIV / Q000276:immunology*; D016655:HIV Core Protein p24 / Q000276:immunology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000939:Epitopes; C066594:Gag protein p27, Simian immunodeficiency virus; D015683:Gene Products, gag; D016655:HIV Core Protein p24