[Study of pantothenic acid derivatives as cardiac protectors in a model of experimental ischemia and reperfusion of the isolated heart].
An isolated heart model with experimental ischemia and reperfusion was used to show effective decrease in lactate, increase in ATP content and prevention of conjugated dienes accumulation in the myocardium by derivatives of pantothenic acid: panthenol (9.0 mg/kg), calcium pantothenate (15.6 mg/kg) and by these ones applied simultaneously as ingredients of perfusate (25 microM) in postischemic period. In that way derivatives of pantothenic acid should be regarded as cardiac protectors.
Kumerova
A O
AO
Utno
L Ia
LIa
Lipsberga
Z E
ZE
Shkestere
I Ia
IIa
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D007773:Lactates / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010204:Pantetheine / Q000031:analogs & derivatives* / Q000494:pharmacology; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury
D007773:Lactates; D010725:Phosphocreatine; D010205:Pantothenic Acid; C007288:dexpanthenol; D010204:Pantetheine; C005425:pantethine; D000255:Adenosine Triphosphate