Calcitonin enhances the effects of nimodipine on biogenic amines of rat brain.
1. Nimodipine affects the brain biogenic amines suggesting both inhibition of the striatal dopaminergic system and activation of serotonergic systems in various brain areas. 2. Salmon calcitonin affects serotonergic systems as nimodipine does. 3. It was hypothesized that these effects could be more than additive since they all have been ascribed to inhibition of neuronal calcium influx. 4. Biogenic amines and metabolites were determined in brain areas obtained from rats pretreated with saline or salmon calcitonin (10 MRC U/kg, s.c.) and treated with nimodipine (2.5-20 mg/kg, i.p.). 5. The effects of nimodipine and salmon calcitonin appeared to be merely additive.
Gaggi
R
R
Department of Pharmacology, University of Bologna, Italy.
Chirivi
L
L
Roncada
P
P
Gianni
A M
AM
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects*; D002116:Calcitonin / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D009553:Nimodipine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism
D001679:Biogenic Amines; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D009553:Nimodipine; D002116:Calcitonin