Oxidative and other DNA damages as the basis of aging: a review.
DNA damages occur continuously in cells of living organisms. While most of these damages are repaired, some accumulate. In particular, there is evidence for DNA damage accumulation in non-dividing cells of mammals. These accumulated DNA damages probably interfere with RNA transcription. We consider that the decline in the ability of DNA to serve as a template for gene expression is the primary cause of aging. Oxidative DNA damages are among the best documented and prevalent DNA damages and are likely to be a prominent cause of aging.
Holmes
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GE
Department of Microbiology, College of Medicine, Howard University, Washington, DC 20059.
Bernstein
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C
Bernstein
H
H
D000375:Aging / Q000235:genetics*; D000818:Animals; D002455:Cell Division; D004247:DNA / Q000235:genetics* / Q000378:metabolism; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D008017:Life Expectancy
D004247:DNA