[Study on the kinetics of bradykinin level in the wound produced by thermal injury in the ear burn model in mice].
The kinetics of bradykinin derived from localized thermal injury on vascular-permeability were investigated in mice with experimental ear burn. The leakage of plasma into the ear tissue by accelerated vascular-permeability reached the maximum at 3 hr and decreased gradually until 6 hr after the thermal injury. The contents of bradykinin increased by the thermal injury and the increment continued up to 24 hr. Although the bradykinin contents in the burned ear decreased by using a protease inhibitor, the hyperpermeability of injured ear vessels was unchanged by protease inhibitors. These results suggest that bradykinin is concerned with the pain reaction rather than vascular-permeability.
Imokawa
H
H
Department of Plastic and Reconstructive Surgery, St. Marianna University School of Medicine, Kanagawa, Japan.
Ando
K
K
Kubota
T
T
Isono
E
E
Inoue
H
H
Ishida
H
H
D000818:Animals; D001920:Bradykinin / Q000378:metabolism* / Q000502:physiology; D002056:Burns / Q000378:metabolism*; D002199:Capillary Permeability; D004195:Disease Models, Animal; D004431:Ear, External / Q000293:injuries; D051379:Mice; D010146:Pain; D011480:Protease Inhibitors / Q000494:pharmacology
D011480:Protease Inhibitors; D001920:Bradykinin