Chloride-dependent cation conductance activated during cellular shrinkage.
A chloride (Cl-)-dependent, nonselective cation conductance was activated during cellular shrinkage and inhibited during cellular swelling or by extracellular gadolinium. The shrinking-induced, nonselective cation conductance and the swelling-induced anion conductance appear to function in the regulation of cell volume in airway epithelia. The shrinking-induced cation conductance had an unusual dependence on Cl-: partial replacement of extracellular Cl- with aspartate reduced the magnitude of the shrinking-enhanced current without accompanying changes in the reversal potential. The Cl- dependence of the nonselective cation conductance could provide a mechanism that tightly regulates Cl- secretion and sodium reabsorption in cells under osmotic stress.
Chan
H C
HC
Department of Medicine, University of Chicago, IL 60637.
Nelson
D J
DJ
D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D000584:Amiloride / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D002412:Cations; D002462:Cell Membrane / Q000502:physiology*; D002463:Cell Membrane Permeability; D002586:Cesium / Q000378:metabolism; D002712:Chlorides / Q000494:pharmacology*; D004553:Electric Conductivity; D004848:Epithelium / Q000502:physiology / Q000648:ultrastructure; D006801:Humans; D007473:Ion Channels / Q000502:physiology*; D008094:Lithium / Q000378:metabolism; D008168:Lung / Q000502:physiology / Q000648:ultrastructure; D008564:Membrane Potentials; D009994:Osmolar Concentration; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
D002412:Cations; D002712:Chlorides; D007473:Ion Channels; D002586:Cesium; D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; D000584:Amiloride; D008094:Lithium; D012964:Sodium; D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; D011188:Potassium; D002118:Calcium