title: Serum autoantibodies against glial fibrillary acidic protein in brain aging and senile dementias.
abstract: Autoantibodies against glial fibrillary acidic protein (GFAP) were investigated by ELISA test in sera of patients suffering from senile dementias and in healthy aging people. One hundred eight subjects divided into control, vascular dementia (VD), presenile Alzheimer's disease (AD), and senile Alzheimer's disease (SDAT) groups were included in the study. VD patients showed the highest antibody titers when compared to controls, whereas AD had the lowest titers when compared to the other groups. These results do not support the utility of anti-GFAP antibodies as useful markers of Alzheimer's disease, suggesting that their presence is a secondary phenomenon to blood-brain barrier disruption.
authors.affiliation: Institute of Gerontology and Geriatrics, University of Perugia, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Mecocci
authors.forename: L
authors.initials: L
authors.lastname: Parnetti
authors.forename: R
authors.initials: R
authors.lastname: Donato
authors.forename: C
authors.initials: C
authors.lastname: Santucci
authors.forename: A
authors.initials: A
authors.lastname: Santucci
authors.forename: D
authors.initials: D
authors.lastname: Cadini
authors.forename: E
authors.initials: E
authors.lastname: Foà
authors.forename: R
authors.initials: R
authors.lastname: Cecchetti
authors.forename: U
authors.initials: U
authors.lastname: Senin
mesh_terms: D000368:Aged; D000375:Aging / Q000276:immunology*; D000544:Alzheimer Disease / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers; D001921:Brain / Q000276:immunology*; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D005904:Glial Fibrillary Acidic Protein