"Carba" peptide bond surrogates. Different approaches to Gly-psi(CH2-CH2)-D,L-Xaa pseudo-dipeptide units.
Racemic "carba" pseudo-dipeptide units such as Gly-psi(CH2-CH2)-D,L-Xaa were obtained either through the Horner-Emmons condensation of N-tert.-butyloxycarbonyl-beta alaninal with the appropriate substituted triethyl phosphonacetate, or from commercially available 3-carbethoxy-2-piperidone.
Rodriguez
M
M
CCIPE, Faculty of Pharmacy, Montpellier, France.
Heitz
A
A
Martinez
J
J
D000478:Alkylation; D004151:Dipeptides / Q000138:chemical synthesis / Q000737:chemistry*; D007536:Isomerism; D009557:Nipecotic Acids / Q000737:chemistry; D010746:Phosphonoacetic Acid / Q000031:analogs & derivatives / Q000737:chemistry
D004151:Dipeptides; D009557:Nipecotic Acids; C076890:3-carbethoxy-2-piperidone; C076891:triethyl phosphonoacetate; D010746:Phosphonoacetic Acid