t(13q;17p) and del(5q): possibly specific changes in Chinese patients with colorectal cancers.
Cytogenetic study of 18 colorectal carcinomas confirmed the extensive heterogeneity and the complexity of the karyotypic picture in this type of tumor. Karyotypic analysis showed that chromosomes 17p and 5q, in both numerical and structural aspects, were the most frequently involved chromosomes and prone to losses. The most common structurally rearranged forms were translocations of 17p with other chromosomes, especially t(13q;17p), which constituted over 50% of all 17p rearrangements, and an interstitial deletion of 5q that made up as much as 73% of all structural abnormalities of 5q. According to the results, we conclude that chromosomes 17 and 5 may play important roles in the evolution of colorectal cancer and t(13q;17p) and del(5q) may be possibly specific to Chinese patients with colorectal cancer.
Wang
L
L
Institute of Cancer Research, West China University of Medical Sciences, Chengdu, Sichuan.
Li
L
L
Zhou
H Y
HY
Gao
X K
XK
Li
S J
SJ
D000328:Adult; D000368:Aged; D002681:China; D002869:Chromosome Aberrations; D002886:Chromosomes, Human, Pair 17; D002895:Chromosomes, Human, Pair 5; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic