Orgaran in hip fracture surgery.
Two studies evaluating the effect of Orgaran prophylaxis on the incidence of postoperative thrombosis in hip fracture surgery are reported. In one Scandinavian study, dextran was used in the comparative group, and in the US study, warfarin was used. In both, Orgaran was significantly more effective in reducing the frequency of deep vein thrombosis without producing an increase in bleeding complications or other side effects.
Bergqvist
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Department of Surgery, Lund University, Malmö General Hospital, Sweden.
D000368:Aged; D000369:Aged, 80 and over; D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D003911:Dextrans / Q000627:therapeutic use; D005260:Female; D006025:Glycosaminoglycans / Q000009:adverse effects / Q000627:therapeutic use*; D006470:Hemorrhage / Q000139:chemically induced; D006496:Heparinoids / Q000009:adverse effects / Q000627:therapeutic use*; D006497:Heparan Sulfate; D006620:Hip Fractures / Q000601:surgery*; D006801:Humans; D015994:Incidence; D008297:Male; D011183:Postoperative Complications / Q000453:epidemiology / Q000401:mortality / Q000517:prevention & control*; D011655:Pulmonary Embolism / Q000453:epidemiology / Q000401:mortality / Q000517:prevention & control*; D012537:Scandinavian and Nordic Countries / Q000453:epidemiology; D016037:Single-Blind Method; D013924:Thrombophlebitis / Q000453:epidemiology / Q000517:prevention & control*; D014481:United States / Q000453:epidemiology; D014859:Warfarin / Q000627:therapeutic use
D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D003911:Dextrans; D006025:Glycosaminoglycans; D006496:Heparinoids; D006497:Heparan Sulfate; D014859:Warfarin; C035838:danaparoid