Increased mutagenicity of some nitroimidazoles by non-mutagenic nitrotoluene on Klebsiella pneumoniae (fluctuation test).
In the fluctuation test the mutation frequency of Klebsiella pneumoniae by the 5-nitroimidazoles panidazole and dimetridazole was increased by adding the non-mutagenic substances 4-nitrotoluene or toluene-4-sulfonamide. This effect was not found with 1-methyl-5-nitroimidazole, metronidazole, ronidazole, nimorazole and 1-methyl-2-hydroxymethyl-5-nitroimidazole. It is suggested that the molecules of panidazole or dimetridazole form some association, which is destroyed by 4-nitrotoluene or toluene-4-sulfonamide, thus increasing the concentration of mutagenic particles.
Voogd
C E
CE
National Institute of Public Health and Environmental Protection, Bilthoven, Netherlands.
van der Stel
J J
JJ
van Bruchem
M C
MC
D004131:Dimetridazole / Q000633:toxicity; D004357:Drug Synergism; D007711:Klebsiella pneumoniae / Q000187:drug effects*; D008795:Metronidazole / Q000633:toxicity; D016296:Mutagenesis; D009554:Nimorazole / Q000633:toxicity; D009593:Nitroimidazoles / Q000633:toxicity*; D013329:Structure-Activity Relationship; D014050:Toluene / Q000031:analogs & derivatives* / Q000633:toxicity
D009593:Nitroimidazoles; C016029:panidazole; D008795:Metronidazole; D014050:Toluene; D009554:Nimorazole; C017572:4-nitrotoluene; D004131:Dimetridazole