Demonstration of mismatch negativity in the monkey.
In humans, deviant auditory stimuli elicit an event-related potential (ERP) component, termed "mismatch negativity" (MMN), that reflects the operation of a cortical detector of infrequent stimulus change. Epidural auditory ERPs were recorded from 3 cynomolgous monkeys in response to soft and loud clicks. "Oddball" loud or soft stimuli elicited a long-duration frontocentral negativity, peaking at approximately 85 msec, that was superimposed upon cortically generated obligatory ERP components. These data suggest that monkeys might serve as a heuristically valuable system in which to study the neurochemical and neuroanatomical substrates of early context-dependent ERP generation.
Javitt
D C
DC
Department of Psychiatry, Albert Einstein College of Medicine, Bronx, NY 10461.
Schroeder
C E
CE
Steinschneider
M
M
Arezzo
J C
JC
Vaughan
H G
HG
D000161:Acoustic Stimulation; D000818:Animals; D001921:Brain / Q000502:physiology*; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D008252:Macaca fascicularis; D008297:Male; D011930:Reaction Time / Q000502:physiology