title: Synthesis and pharmacological activity of 4-carbamoyl-5-aryl-6-methyl-4,5-dihydropyridazin-3(2H)-ones.
abstract: A new series of 4-carbamoyl-5-aryl-6-methyl-4,5-dihydropyridazin-3(2H)-ones have been synthesized and tested for their antiinflammatory and analgesic properties. Amongst the test compounds, only 31 showed antiinflammatory activity, though of shorter duration than that of indomethacin, taken as reference drug. On the contrary, many derivatives displayed relevant analgesic activity, 4--the only 4,5-dehydroderivative--being the most potent in the writhing test. In the hot plate test 3b, 3f and 3k were found to possess the most significant analgesic properties.
authors.affiliation: Istituto Chimica Farmaceutica, Sassari, Italia.
authors.forename: G A
authors.initials: GA
authors.lastname: Pinna
authors.forename: F
authors.initials: F
authors.lastname: Sardu
authors.forename: M M
authors.initials: MM
authors.lastname: Curzu
authors.forename: M
authors.initials: M
authors.lastname: Satta
authors.forename: A
authors.initials: A
authors.lastname: Peana
authors.forename: G
authors.initials: G
authors.lastname: Cignarella
authors.forename: D
authors.initials: D
authors.lastname: Barlocco
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D051379:Mice; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011724:Pyridazines; D007213:Indomethacin