title: Hyperglucagonemia induced in mice by tryptamine: involvement of the peripheral 5-HT2 receptors.
abstract: The effects of an indoleamine, tryptamine, on plasma glucagon levels were investigated in mice. Tryptamine induced dose-related increases in plasma glucagon levels. The hyperglucagonemia effects of tryptamine were completely antagonized by methysergide and ketanserin which have a high affinity to 5-HT2 receptors. In addition, the peripheral 5-HT2 receptor antagonist, xylamidine, also strongly inhibited tryptamine-induced hyperglucagonemia. Our results indicate that the peripheral 5-HT2 receptors mediate the increase in plasma glucagon levels induced by tryptamine and that these receptors may have a role in the control of glucagon secretion.
authors.affiliation: Department of Pharmacology, Kobe Women's College of Pharmacy, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Yamada
authors.forename: Y
authors.initials: Y
authors.lastname: Sugimoto
authors.forename: I
authors.initials: I
authors.lastname: Kimura
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
authors.forename: N
authors.initials: N
authors.lastname: Takeuchi
authors.forename: K
authors.initials: K
authors.lastname: Horisaka
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005934:Glucagon / Q000097:blood*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000494:pharmacology; D014363:Tryptamines / Q000494:pharmacology*
chemical_list: D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D014363:Tryptamines; C030820:tryptamine; D005934:Glucagon