Which brain defects accompany cyclopia?
We report a fetus with an association of cyclopia without proboscis, aprosencephaly and agnathia. Analysing literature cases and the case presented here we can suggest that: 1) not only alobar holoprosencephaly but also more severe forebrain anomalies can be a brain equivalent of cyclopia; 2) aprosencephaly can be viewed as the earliest known variant of prosencephalic series; and 3) "agnathia-holoprosencephaly" association is etiologically heterogeneous.
Lurie
I W
IW
Byelorussian Institute of Hereditary Disease, Minsk.
Kirillova
I A
IA
Nedzved
M K
MK
Krapiva
G A
GA
D000015:Abnormalities, Multiple / Q000000981:diagnostic imaging / Q000235:genetics*; D000025:Abortion, Eugenic; D000328:Adult; D001921:Brain / Q000473:pathology; D005124:Eye Abnormalities / Q000000981:diagnostic imaging / Q000235:genetics*; D005260:Female; D016142:Holoprosencephaly / Q000000981:diagnostic imaging / Q000235:genetics*; D006801:Humans; D008844:Micrognathism / Q000000981:diagnostic imaging / Q000235:genetics; D011247:Pregnancy; D016216:Ultrasonography, Prenatal