[Transport of Ca2+ in the sarcoplasmic reticulum of skeletal muscles in hyperthermia].
Study of functional changes in sarcoplasmic reticulum membranes of the rat skeletal muscles shows that mild hyperthermia is accompanied by the activation of Ca-transporting system function (the increase in accumulation of Ca ions and the rise of Ca(2+)-ATPase activity are observed), a passive release of this ion being unchanged. The revealed changes are regarded as reaction induced by the body temperature increase. The effectiveness of the SR Ca-pump decreases sharply under heat stroke, but the increase of Ca2+ release from SR vesicles is observed. This is considered to be one of possible factors, causing disorder of electromechanical coupling and the disturbance of the skeletal muscle contractility.
Avetisova
N L
NL
Fedorov
A N
AN
Seferova
R I
RI
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D002413:Cations, Divalent; D005334:Fever / Q000378:metabolism*; D006868:Hydrolysis; D007700:Kinetics; D008297:Male; D009132:Muscles / Q000378:metabolism*; D051381:Rats; D012519:Sarcoplasmic Reticulum / Q000378:metabolism*
D002413:Cations, Divalent; D000255:Adenosine Triphosphate; D000252:Calcium-Transporting ATPases; D002118:Calcium