title: Coumarins from Phebalium tuberculosum ssp. megaphyllum and Phebalium filifolium.
abstract: A total of 14 coumarins have been isolated from the aerial parts of Phebalium tuberculosum ssp. megaphyllum and 9 from Phebalium filifolium (Rutaceae). Three of the coumarins obtained from P. tuberculosum ssp. megaphyllum are novel and have been characterized, on the basis of spectroscopic analysis, as (E)-7-(6-hydroperoxy-3,7-dimethylocta-2,7- dienyloxy)coumarin [3], (E)-8-(6-hydroperoxy-3,7-dimethylocta-2,7-dienyloxy)psoralen [16] and (E,E)-8-(7-hydroxy-3,7-dimethylocta-2,5-dienyloxy)psoralen [15] In addition, both species yielded the simple acetophenone xanthoxylin, and P. tuberculosum ssp. megaphyllum gave (E)-betulin-3-p-coumarate [20] and (Z)-betulin-3-p-coumarate [21], both of which appear to be novel. The chemotaxonomic implications of coumarin distribution in the two species are discussed.
authors.affiliation: Department of Pharmaceutical Sciences, University of Strathclyde, Scotland, UK.
authors.forename: M A
authors.initials: MA
authors.lastname: Rashid
authors.forename: A I
authors.initials: AI
authors.lastname: Gray
authors.forename: P G
authors.initials: PG
authors.lastname: Waterman
authors.forename: J A
authors.initials: JA
authors.lastname: Armstrong
mesh_terms: D002853:Chromatography, Liquid; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D015394:Molecular Structure; D010946:Plants, Medicinal
chemical_list: D003374:Coumarins