Sister-chromatid exchange induction produced by in vivo and in vitro exposure to alpha-asarone.
The effect of alpha-asarone, a chemical with hypocholesterolemic properties extracted from Guatteria gaumeri, on SCE induction was studied both in human lymphocytes in vitro and in murine bone marrow cells in vivo. A slight but consistent increase in SCE was observed in both biological systems.
Morales-Ramírez
P
P
Instituto Nacional de Investigaciones Nucleares, Mexico DF Mexico.
Madrigal-Bujaidar
E
E
Mercader-Martínez
J
J
Cassini
M
M
González
G
G
Chamorro-Cevallos
G
G
Salazar-Jacobo
M
M
D000081248:Allylbenzene Derivatives; D000818:Animals; D000840:Anisoles / Q000633:toxicity*; D000924:Anticholesteremic Agents / Q000633:toxicity*; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D016009:Chi-Square Distribution; D004261:DNA Replication / Q000187:drug effects; D006801:Humans; D016018:Least-Squares Analysis; D007928:Lethal Dose 50; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D008800:Mexico; D051379:Mice; D008807:Mice, Inbred BALB C; D008940:Mitotic Index / Q000187:drug effects; D016296:Mutagenesis; D010946:Plants, Medicinal; D012854:Sister Chromatid Exchange
D000081248:Allylbenzene Derivatives; D000840:Anisoles; D000924:Anticholesteremic Agents; C012195:asarone