title: Hyaluronan and cell locomotion.
abstract: Hyaluronan (HA), a glycosaminoglycan, has long been implicated in cell locomotion. We have shown that HA production regulates the locomotion of H-ras-transformed cells. This autocrine motility mechanism is mediated by a novel HA receptor termed RHAMM, an acronym for Receptor for HA Mediated Motility. HA:RHAMM interactions regulate directional locomotion of tumor cells and result in enhanced protein tyrosine phosphorylation that may be a critical messenger mechanism for initiation of locomotion.
authors.affiliation: Manitoba Institute of Cell Biology, Winnipeg, Canada.
authors.forename: E A
authors.initials: EA
authors.lastname: Turley
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D011905:Genes, ras / Q000502:physiology; D006801:Humans; D018960:Hyaluronan Receptors; D006820:Hyaluronic Acid / Q000502:physiology*; D009369:Neoplasms / Q000503:physiopathology; D051381:Rats; D011956:Receptors, Cell Surface / Q000502:physiology; D014945:Wound Healing / Q000502:physiology
chemical_list: D018960:Hyaluronan Receptors; D011956:Receptors, Cell Surface; D006820:Hyaluronic Acid