[Effect of enoxacin on theophylline pharmacokinetics].
The effect of a multiple-dose regimen of oral Enoxacin on Theophylline pharmacokinetics was evaluated in 10 hospitalized patients with COPD. It was found that mean Theophylline concentrations in serum significantly increased 144% (P < 0.01), AUC increased 350.4% (P < 0.01), T1/2K increased 204% (P < 0.01), clearance decreased 76.8% (P < 0.01) during coadministration of enoxacin than before. This results suggested that a multidose regimen of enoxacin significantly slowed the clearance of theophylline and elevated theophylline concentrations in serum. The careful monitoring of serum theophylline level and modification of theophylline dosage in patients receiving enoxacin and theophylline were recommended.
Liu
Y N
YN
General Hospital of P.L.A.
D000328:Adult; D000368:Aged; D000628:Aminophylline / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004347:Drug Interactions; D015365:Enoxacin / Q000627:therapeutic use*; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D008875:Middle Aged
D000628:Aminophylline; D015365:Enoxacin