title: Anti-aids agents, 6. Salaspermic acid, an anti-HIV principle from Tripterygium wilfordii, and the structure-activity correlation with its related compounds.
abstract: Salaspermic acid [1], an inhibitor of HIV reverse transcriptase and HIV replication in H9 lymphocyte cells, was isolated from the roots of Tripterygium wilfordii for the first time. The structure of 1 derived from spectral data was established unequivocally by an X-ray analysis of crystals of the monohydrate. A structure-activity correlation of 1 with ten related compounds indicated that the acetal linkage in ring A and the carboxyl group in ring E of 1 may be required for the anti-HIV activity.
authors.affiliation: Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599.
authors.forename: K
authors.initials: K
authors.lastname: Chen
authors.forename: Q
authors.initials: Q
authors.lastname: Shi
authors.forename: Y
authors.initials: Y
authors.lastname: Kashiwada
authors.forename: D C
authors.initials: DC
authors.lastname: Zhang
authors.forename: C Q
authors.initials: CQ
authors.lastname: Hu
authors.forename: J Q
authors.initials: JQ
authors.lastname: Jin
authors.forename: H
authors.initials: H
authors.lastname: Nozaki
authors.forename: R E
authors.initials: RE
authors.lastname: Kilkuskie
authors.forename: E
authors.initials: E
authors.lastname: Tramontano
authors.forename: Y C
authors.initials: YC
authors.lastname: Cheng
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D054303:HIV Reverse Transcriptase; D015497:HIV-1 / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000382:microbiology; D008968:Molecular Conformation; D010946:Plants, Medicinal / Q000737:chemistry*; D018894:Reverse Transcriptase Inhibitors; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*; D014961:X-Ray Diffraction
chemical_list: D000998:Antiviral Agents; D018894:Reverse Transcriptase Inhibitors; D014315:Triterpenes; C074717:salaspermic acid; D054303:HIV Reverse Transcriptase