Preparation and biological behaviour of some neutral 99mTc-carbonyl dithiocarbamates showing rapid hepatobiliary excretion.
A simple procedure for the preparation of 99mTc-carbonyl complexes of dithiocarbamates in high yield and radiochemical purity has been developed and used for the preparation of 99mTc-carbonyl complexes of bis(2-hydroxyethyl)dithiocarbamate and bis(2-hydroxypropyl)dithiocarbamate. These complexes were found to be extremely stable and their biological behaviour was studied in mice and compared to that of the 99mTcN- and the 99mTc-complexes [prepared by dithionite (dit) reduction] of the same ligands. The carbonyl complexes were found to be efficient hepatobiliary agents and cleared more rapidly than the corresponding 99mTcN- and 99mTc(dit)-complexes.
Baldas
J
J
Australian Radiation Laboratory, Yallambie.
Bonnyman
J
J
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005704:Gallbladder / Q000378:metabolism*; D007202:Indicators and Reagents; D008099:Liver / Q000378:metabolism*; D051379:Mice; D013667:Technetium / Q000493:pharmacokinetics*; D013859:Thiocarbamates / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D007202:Indicators and Reagents; D013859:Thiocarbamates; D013667:Technetium