title: [A case of aortic valve stenosis and regurgitation with idiopathic thrombocytopenic purpura].
abstract: A patient of aortic valvular disease with idiopathic thrombocytopenic purpura underwent aortic valvular replacement. We report a preventive measure against the intra and postoperative bleeding. The patient was a 67-year-old man. He was diagnosed as aortic valvular stenosis with regurgitation. There was no abnormal data about the coagulation test. Thrombocyte count was 8.2 x 10(4)/mm3, but thrombocytopenic life span had shortened 3.8 days. So, we used gamma-globulin 400 mg/kg/day for 5 days before the day of operation and infused blood platelets on the day of operation. There was no problem intra and postoperative period. On the 14th postoperative day thrombocyte count increased to 22.9 x 10(4)/mm3, and thrombocytopenic life span returned to normal range (7.6 days). But on the 45th day of postoperation, thrombocyte count decreased to 11.0 x 10(4)/mm3. We think that many gamma-globulin medication is a useful method to prevent intra and postoperative bleeding resulting from idiopathic thrombocytopenic purpura.
authors.affiliation: Second Department of Surgery, Shinsyu University School of Medicine.
authors.forename: Y
authors.initials: Y
authors.lastname: Nimura
authors.forename: M
authors.initials: M
authors.lastname: Morimoto
authors.forename: H
authors.initials: H
authors.lastname: Nohara
authors.forename: Y
authors.initials: Y
authors.lastname: Fukaya
authors.forename: K
authors.initials: K
authors.lastname: Nishimura
authors.forename: H
authors.initials: H
authors.lastname: Nakano
authors.forename: H
authors.initials: H
authors.lastname: Miwa
authors.forename: N
authors.initials: N
authors.lastname: Yanagiya
authors.forename: M
authors.initials: M
authors.lastname: Shinohara
authors.forename: S
authors.initials: S
authors.lastname: Haruta
mesh_terms: D000368:Aged; D001021:Aortic Valve / Q000601:surgery; D001022:Aortic Valve Insufficiency / Q000150:complications / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000150:complications / Q000601:surgery*; D006350:Heart Valve Prosthesis; D006801:Humans; D007116:Immunization, Passive; D008297:Male; D011696:Purpura, Thrombocytopenic / Q000150:complications* / Q000628:therapy; D005719:gamma-Globulins / Q000008:administration & dosage
chemical_list: D005719:gamma-Globulins