Antitumor action of retinoids: inhibition of tumor cell line-induced angiogenesis and prevention of tumors in mice.
Acitretin was shown to inhibit angiogenic response to the tumorigenic SKV cell line bearing HPV16 genome and to sarcoma L-1 cell line, both in vitro and in vivo systems. The lowered angiogenic response to tumor cells was independent of duration and timing of the application of acitretin to animals. Acitretin, but not etretinate, was also found to be effective in the prevention of sarcoma tumors in mice.
Szmurlo
A
A
Dermatology Department, Warsaw School of Medicine, Poland.
Marczak
M
M
Jablonska
S
S
Bollag
W
W
D017255:Acitretin; D000818:Animals; D005050:Etretinate / Q000494:pharmacology* / Q000627:therapeutic use; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D009389:Neovascularization, Pathologic; D012513:Sarcoma, Experimental / Q000517:prevention & control; D014212:Tretinoin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D014407:Tumor Cells, Cultured
D014212:Tretinoin; D005050:Etretinate; D017255:Acitretin