Idiopathic hypereosinophilic syndrome terminating in acute lymphoblastic leukemia.
Idiopathic hypereosinophilic syndrome (IHES) is a heterogeneous group of disorders characterized by multisystem dysfunction and persistent, extreme eosinophilia of unknown cause. We describe a 9-1/2-year-old boy whose course included several unusual clinical features and terminated 2 years after diagnosis in acute lymphoblastic leukemia (ALL). Serial studies suggest that leukemia was not present earlier in his course. We speculate that this child may have had an evolving lymphoproliferative syndrome with a terminal blast crisis to which the eosinophilia was a nonmalignant leukemoid reaction.
Blatt
J
J
Department of Pediatrics, Children's Hospital, Pittsburgh, Pennsylvania 15213-3417.
Proujansky
R
R
Horn
M
M
Phebus
C
C
Longworth
D
D
Penchansky
L
L
D000943:Antigens, Differentiation / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D002648:Child; D004802:Eosinophilia / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D006412:Hematopoietic Stem Cells / Q000473:pathology; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000473:pathology; D008297:Male; D015260:Neprilysin; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma; D011289:Preleukemia / Q000188:drug therapy / Q000473:pathology*; D013577:Syndrome; D013921:Thrombocytopenia / Q000150:complications
D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D015260:Neprilysin