Influence of thyroid hormone deficiency in DNA contents in different areas of adult rat brain.
We have studied DNA concentrations in various regions of the adult rat brain in prolonged hypothyroidism of different origin. In both normal and hypothyroid rats hypophysis, cerebellum and hypothalamus contained the highest concentrations of DNA. Hypothyroidism produced a slight decrease in DNA content but this effect varied according to the different regions. These variations were due to changes in their maturation period, a critical and specific target for thyroid hormone action after birth.
Serrano-Lozano
A
A
Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad de Málaga, Spain.
Morata
P
P
Montiel
M
M
Miranda
M T
MT
Morell
M
M
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism; D007037:Hypothyroidism / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D010902:Pituitary Gland / Q000378:metabolism; D011441:Propylthiouracil; D051381:Rats; D011919:Rats, Inbred Strains; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D011441:Propylthiouracil; D004247:DNA; D013974:Thyroxine