dup(12)(q13----qter) in two t(14;18)-negative follicular B-non-Hodgkin's lymphomas.
Two t(14;18)-negative follicular B-non-Hodgkin's lymphomas with the same chromosomal abnormality, dup(12)(q13----qter), are presented. The absence of a BCL2 gene rearrangement was confirmed by molecular studies in both cases. Instead, duplication of a 12q segment was found. Further evidence for the presence of the dup(12)(q13----qter) was found using fluorescence in situ hybridization. dup(12q) may be equivalent to the trisomy 12 originally described in B-chronic lymphocytic leukemia. This chromosome anomaly has also been reported in B-non-Hodgkin's lymphomas, usually in association with other chromosome anomalies and a more aggressive tumor phenotype. Occurrence of dup(12q) in two histologically similar cases of follicular small cleaved-cell lymphoma without a typical t(14;18), suggests that this karyotypic change may play a critical role in some cases of follicle center-cell lymphomas.
Wlodarska
I
I
Center for Human Genetics, University of Leuven, Belgium.
Mecucci
C
C
Vandenberghe
E
E
De Wolf-Peeters
C
C
Thomas
J
J
Hilliker
C
C
Schoenmakers
E
E
Stul
M
M
Marynen
P
P
Cassiman
J J
JJ
D000368:Aged; D002869:Chromosome Aberrations; D002881:Chromosomes, Human, Pair 12; D002883:Chromosomes, Human, Pair 14; D002887:Chromosomes, Human, Pair 18; D015342:DNA Probes / Q000235:genetics; D005260:Female; D005453:Fluorescence; D006801:Humans; D016393:Lymphoma, B-Cell / Q000235:genetics*; D008224:Lymphoma, Follicular / Q000235:genetics*; D009693:Nucleic Acid Hybridization
D015342:DNA Probes