title: Tissue responses to Hydron, assessed by intramuscular implantation.
abstract: Freshly mixed polymerized Hydron root canal filling material, fully set AH26 and Teflon were implanted in the quadriceps muscle of guinea pigs and assessed histologically at 2 days, 1, 2, 3, 12 and 26 weeks after implantation. All materials were characterized by peri-implant fibrous connective tissue capsule formation. Von Kossa-positive calcific material was observed at the implant-tissue interface of Hydron implants. The amount of apparently calcified material increased with time. Inflammation was not a prominent tissue response for any of the test materials, nor was a foreign body giant cell response.
authors.affiliation: The University of Adelaide, South Australia.
authors.forename: R J
authors.initials: RJ
authors.lastname: Reid
authors.forename: D F
authors.initials: DF
authors.lastname: Wilson
authors.forename: K K
authors.initials: KK
authors.lastname: Chau
authors.forename: G S
authors.initials: GS
authors.lastname: Heithersay
authors.forename: P S
authors.initials: PS
authors.lastname: Heijkoop
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001729:Bismuth / Q000633:toxicity; D004338:Drug Combinations; D004853:Epoxy Resins; D005549:Foreign-Body Reaction; D006168:Guinea Pigs; D020100:Hydrogels; D007249:Inflammation / Q000139:chemically induced; D008262:Macrophage Activation; D008297:Male; D008422:Materials Testing; D008709:Methenamine / Q000633:toxicity; D009132:Muscles / Q000187:drug effects*; D011102:Polyhydroxyethyl Methacrylate / Q000031:analogs & derivatives* / Q000633:toxicity; D011138:Polytetrafluoroethylene / Q000633:toxicity; D019736:Prostheses and Implants; D012387:Root Canal Filling Materials / Q000633:toxicity*; D012834:Silver / Q000633:toxicity; D014025:Titanium / Q000633:toxicity
chemical_list: D001672:Biocompatible Materials; D004338:Drug Combinations; D004853:Epoxy Resins; D020100:Hydrogels; D012387:Root Canal Filling Materials; C000257:polyhydroxyethyl methacrylate hydrogels; D011102:Polyhydroxyethyl Methacrylate; D012834:Silver; C028044:epoxy resin AH-26; D011138:Polytetrafluoroethylene; D014025:Titanium; D008709:Methenamine; D001729:Bismuth