title: Distribution of ICAM-1, LFA-3 and HLA-DR in healthy and diseased gingival tissues.
abstract: Cell adhesion molecules are involved in recognition and effector aspects of the host response, including the control of migration of leukocytes into inflammatory sites. In this study we have demonstrated that the distribution of three cell-surface molecules involved in cell interactions, ICAM-1, LFA-3 and HLA-DR is distinct and different in healthy and diseased gingival tissue. ICAM-1 was consistently expressed by junctional epithelial cells in healthy gingiva and by pocket epithelium in diseased gingiva but was not detectable on the majority of keratinocytes in external gingival epithelium. ICAM-1 was also expressed by endothelial cells of gingival blood vessels and a subset of leukocytes in the infiltrated connective tissue in both healthy and diseased gingiva. HLA-DR and LFA-3 were also expressed by epithelial cells and endothelial cells but in patterns which were distinctly different from ICAM-1.
authors.affiliation: Center for Research in Periodontal Diseases and Oral Molecular Biology, University of Illinois, Chicago.
authors.forename: J M
authors.initials: JM
authors.lastname: Crawford
mesh_terms: D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis*; D018968:CD58 Antigens; D015815:Cell Adhesion Molecules / Q000032:analysis*; D004730:Endothelium, Vascular / Q000276:immunology; D004846:Epithelial Attachment / Q000276:immunology*; D005881:Gingiva / Q000276:immunology*; D005888:Gingival Pocket / Q000276:immunology*; D005891:Gingivitis / Q000276:immunology; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D018799:Intercellular Adhesion Molecule-1; D007962:Leukocytes / Q000276:immunology; D008562:Membrane Glycoproteins / Q000032:analysis*; D010518:Periodontitis / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D018968:CD58 Antigens; D015815:Cell Adhesion Molecules; D006684:HLA-DR Antigens; D008562:Membrane Glycoproteins; D018799:Intercellular Adhesion Molecule-1