Cerebral cortical amyloid protein precursor mRNA expression is similar in Alzheimer's disease and other neurodegenerative diseases.
The expression of 3 beta-amyloid protein precursor (APP) mRNAs (695, 751, and 770) in the cerebral cortex in Alzheimer's disease and other neurodegenerative diseases was analyzed by the S1 nuclease protection assay. We found no significant Alzheimer's disease-specific alteration of APP mRNA expression when compared to the other neurological diseases as controls. Since the expression of this mRNA was not correlated with amyloid deposition, it is possible that gliosis/neuronal loss may secondarily alter APP mRNA expression. However, the current study revealed no significant correlation between them.
Ohyagi
Y
Y
Division of Demyelinating Disease and Aging, National Center of Neurology and Psychiatry, Tokyo, Japan.
Takahashi
K
K
Satoh
Y
Y
Makifuchi
T
T
Tabira
T
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D016564:Amyloid beta-Protein Precursor / Q000096:biosynthesis*; D015152:Blotting, Northern; D002540:Cerebral Cortex / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000378:metabolism* / Q000473:pathology; D012333:RNA, Messenger / Q000096:biosynthesis*; D015719:Single-Strand Specific DNA and RNA Endonucleases / Q000378:metabolism
D016564:Amyloid beta-Protein Precursor; D012333:RNA, Messenger; D015719:Single-Strand Specific DNA and RNA Endonucleases