title: Epilepsy in the first 10 years of life: findings of the child health and education study.
abstract: OBJECTIVE
  To identify children with afebrile seizures in a national cohort, classify the seizures, and document progress in the first 10 years of life.
  
  
  METHODS
  Population based birth cohort study.
  
  
  METHODS
  The child health and education study, which includes 16,004 neonatal survivors (98.5% of infants born in the United Kingdom during one week of April 1970).
  
  
  METHODS
  14,676 children for whom relevant information was available.
  
  
  METHODS
  Responses to parental and general practitioner questionnaires and hospital records at 5 and 10 years after birth.
  
  
  RESULTS
  84 children (42 boys, 42 girls) had had one or more afebrile seizure (incidence 5.7/1000). 63 children (31 boys, 32 girls) had epilepsy (incidence 4.3/1000). 49 of 55 children had a second seizure within a year of the first. The commonest seizure types were tonic-clonic (42) and complex partial (25). A greater proportion of children with complex partial seizures had recurrences. Children who had infantile spasms or a mixed seizure disorder had a poor outcome. All six children who died had symptomatic seizures in the first year, but seizures were not the direct cause of death.
  
  
  CONCLUSIONS
  The results of this study are probably representative of seizure patterns in the general population. Outcome after seizures is determined more by the underlying disease than by the seizures themselves.
authors.affiliation: Department of Paediatrics, Addenbrooke's Hospital, Cambridge.
authors.forename: C M
authors.initials: CM
authors.lastname: Verity
authors.forename: E M
authors.initials: EM
authors.lastname: Ross
authors.forename: J
authors.initials: J
authors.lastname: Golding
mesh_terms: D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D002658:Developmental Disabilities / Q000453:epidemiology; D004827:Epilepsy / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D005192:Family Health; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007859:Learning Disabilities / Q000453:epidemiology; D008297:Male; D012008:Recurrence; D012307:Risk Factors; D013997:Time Factors; D006113:United Kingdom / Q000453:epidemiology