[Increased serum levels of IgA and C4 in atherosclerosis: the absence of a correlation with the arteriographic picture].
We have previously shown that an increase in serum IgA and C4 is often detectable in presence of diffuse atherosclerotic disease. The present study was performed to verify such results in a different and larger sample of subjects, and to ascertain whether the above immunologic variables are correlated with the severity of atherosclerotic disease. Seventy-three atherosclerotic subjects with at least 1 significant (> 75%) stenosis in a major arterial branch were selected according to the reports of arterial panangiographies performed previously. Among them, 36 subjects (24 men and 12 women, mean age 63 +/- 7 years) were singled out, who matched by age and sex 36 control subjects (mean age 63 +/- 7 years). In all of these subjects the following serum immunologic and lipid variables were measured: IgG, IgA, IgM, IgE, C3, C4, total cholesterol, HDL-cholesterol and triglycerides. With respect to the controls, the 36 matched atherosclerotic subjects had higher levels of IgA (263.0 +/- 119.8 vs 334.3 +/- 130.5 mg/dl; p = 0.0126), C4 (25.7 +/- 5.8 vs 30.4 +/- 9.1 mg/dl; p = 0.0297) and triglycerides (153.1 +/- 77.3 vs 209.7 +/- 141.3; p = 0.0500). No correlation was found between the number of arterial stenoses (range 1-8, mean 2.9 +/- 1.5) and any of the immunologic or lipid parameters in all the 73 atherosclerotic subjects. Only the daily cigarette consumption was correlated with the disease extension (tau = 0.1984; p = 0.0392).(ABSTRACT TRUNCATED AT 250 WORDS)
Bozzoli
C
C
Istituto di Patologia Speciale Medica e Metodologia Clinica, Università degli Studi, Bologna.
Muscari
A
A
Puddu
G M
GM
Vallar
G
G
Renzi
C
C
Miniero
R
R
Rovinetti
C
C
Puddu
P
P
D000368:Aged; D001161:Arteriosclerosis / Q000097:blood / Q000000981:diagnostic imaging* / Q000276:immunology*; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007136:Immunoglobulins / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D011859:Radiography
D003176:Complement C3; D003181:Complement C4; D007070:Immunoglobulin A; D007136:Immunoglobulins; D008055:Lipids