Neurofibromatosis and central nervous system tumors in childhood.
Neurofibromatosis is a multifaceted disease that often results in tumors of the central nervous system. As our understanding of the molecular biology of the disease improves along with better neuroradiology imaging, surgical instrumentation, and adjunctive care, the management schemes for these patients are evolving. This article reviews what is known about neurofibromatosis, common management problems with respect to the central nervous system, and an approach to the handling of these issues.
Mapstone
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Department of Neurological Surgery, Case Western Reserve University School of Medicine, Cleveland, Ohio.
D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery; D002648:Child; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D009456:Neurofibromatosis 1 / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery; D016518:Neurofibromatosis 2 / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery; D012307:Risk Factors