title: Expression of the bcl-2 gene product in follicular lymphoma.
abstract: Expression of bcl-2 protein was analyzed in 140 cases of follicular lymphoma by immunohistologic staining of paraffin-embedded tissue; 85% of cases were positive, the frequency being related to histologic grade (100% for the small-cleaved cell type, 86% for the mixed cell type, and 76% for the large cell group). There was striking heterogeneity of bcl-2 content in a number of cases and the smaller neoplastic cells (i.e., centrocytes) were usually the most strongly labeled. In most cases, bcl-2 protein staining was much weaker in normal lymphoid cells than in the neoplastic cells. In several cases, staining for bcl-2 revealed patterns of neoplastic cell spread into adjacent tissue (e.g., normal follicles, lymphoid sinuses), and bcl-2 protein expression tended to be highest in these migratory cells.
authors.affiliation: Department of Pathology, Henri Mondor Hospital, Créteil, France.
authors.forename: P
authors.initials: P
authors.lastname: Gaulard
authors.forename: M F
authors.initials: MF
authors.lastname: d'Agay
authors.forename: M
authors.initials: M
authors.lastname: Peuchmaur
authors.forename: N
authors.initials: N
authors.lastname: Brousse
authors.forename: C
authors.initials: C
authors.lastname: Gisselbrecht
authors.forename: P
authors.initials: P
authors.lastname: Solal-Celigny
authors.forename: J
authors.initials: J
authors.lastname: Diebold
authors.forename: D Y
authors.initials: DY
authors.lastname: Mason
mesh_terms: D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008224:Lymphoma, Follicular / Q000378:metabolism* / Q000473:pathology; D009361:Neoplasm Invasiveness; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2; D013194:Staining and Labeling
chemical_list: D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2