New diketopiperazine metabolites from the sclerotia of Aspergillus ochraceus.
Three new diketopiperazine-containing metabolites 1-3 have been isolated from the sclerotia of Aspergillus ochraceus (NRRL 3519) by chromatography on Sephadex LH-20 and reversed-phase hplc. The structures of these compounds were established using extensive high-field 1D and 2D nmr experiments. All three compounds cause moderate reduction in weight gain in assays against the lepidopteran crop pest Helicoverpa zea.
de Guzman
F S
FS
Department of Chemistry, University of Iowa, Iowa City 52242.
Gloer
J B
JB
Wicklow
D T
DT
Dowd
P F
PF
D000596:Amino Acids / Q000032:analysis; D001230:Aspergillus / Q000737:chemistry*; D054659:Diketopiperazines; D015394:Molecular Structure; D010879:Piperazines / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism
D000596:Amino Acids; D054659:Diketopiperazines; D010879:Piperazines