[Metallic mesh endoprosthesis and intraluminal high dose rate 192Ir brachytherapy in the palliative treatment of malignant bile duct obstruction. Initial results].
Since December 1989, 9 patients with inoperable malignant biliary tract obstruction were treated palliatively by a combined modality treatment consisting of placement of a permanent biliary endoprosthesis followed by intraluminal high dose-rate 192Ir brachytherapy. A dose of 10 Gy was delivered in a hyperfractionated schedule at the point of reference in a distance of 7.5 mm of centre of the source. External small field radiotherapy (50.4 Gy, 1.8 Gy per day, 5 fractions per week) was also given in six cases (M/O, Karnofsky greater than 60%). In 9/9 cases an unrestrained bile flow and an interruption of pruritus was achieved, in 78% (7/9) of cases the duration of palliation was as long as the survival time (median survival time 7.5 months).
Pakisch
B
B
Abteilung für Strahlentherapie, Universitäts-Klinik für Radiologie, Graz.
Klein
G E
GE
Stücklschweiger
G
G
Lammer
J
J
Poier
E
E
Leitner
H
H
Poschauko
J
J
Hausegger
K A
KA
Hackl
A
A
D000230:Adenocarcinoma / Q000150:complications*; D000328:Adult; D000368:Aged; D001650:Bile Duct Neoplasms / Q000150:complications*; D001918:Brachytherapy; D002779:Cholestasis / Q000209:etiology* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D005706:Gallbladder Neoplasms / Q000150:complications*; D006801:Humans; D007496:Iridium Radioisotopes / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D015607:Stents
D007496:Iridium Radioisotopes