title: Effects of verapamil on [3H]acetylcholine release in the striatum of spontaneously hypertensive rats.
abstract: In the present study, we describe the effects of Ca2+ channel antagonist (verapamil) on [3H]acetylcholine (ACh) release in the central nervous system of spontaneously hypertensive rats (SHR). The electrically stimulated release of [3H]ACh from striatal slices was not different between SHR and normotensive Wistar Kyoto (WKY) rats. Verapamil inhibited electrically stimulated [3H]ACh release in a dose-related fashion. The inhibitory effect of verapamil was significantly greater in SHR than in WKY rats. These results suggest that the Ca2+ sensitivity of central cholinergic neurons might be enhanced in SHR, which could attribute, at least partially, to the pathogenesis of hypertension.
authors.affiliation: Department of Medicine, Wakayama Medical College, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tsuda
authors.forename: S
authors.initials: S
authors.lastname: Tsuda
authors.forename: Y
authors.initials: Y
authors.lastname: Masuyama
authors.forename: M
authors.initials: M
authors.lastname: Goldstein
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D014700:Verapamil / Q000494:pharmacology*
chemical_list: D014700:Verapamil; D000109:Acetylcholine