Clastogenicity of 2-chlorobenzylidene malonitrile (CS) in V79 Chinese hamster cells.
The clastogenicity of the sensory irritant 2-chlorobenzylidene malonitrile (CS) to V79 Chinese hamster cells was investigated at various exposure conditions. CS efficiently induced chromatid-type aberrations in a dose-dependent manner provided the cells could run through at least one or two S-phases during a 20-h exposure over a 3-h exposure followed by a 20-h recovery period (cell cycle time 8-10 h). The induction of SCEs indicates an S-dependent mechanism. The hydrolysis products o-chlorobenzaldehyde and malonitrile were inactive in these experiments.
Bauchinger
M
M
Institut für Strahlenbiologie, GSF-Forschungszentrum für Umwelt und Gesundheit mbH, Neuherberg, Germany.
Schmid
E
E
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D006224:Cricetinae; D009153:Mutagens / Q000378:metabolism / Q000633:toxicity*; D009763:o-Chlorobenzylidenemalonitrile / Q000378:metabolism / Q000633:toxicity*
D009153:Mutagens; D009763:o-Chlorobenzylidenemalonitrile