title: Difference in the concentration of tryptophan metabolites between maternal and umbilical foetal blood.
abstract: Maternal and umbilical foetal blood at delivery were analysed for tryptophan metabolites by using fully automated high-performance liquid chromatography. The metabolites detected in 100 microliters of maternal plasma were kynurenine, serotonin, 5-hydroxyindoleacetic acid, indolelactic acid, indoleacetic acid and indolepropionic acid. These metabolites were present in various amounts in the protein-bound form. Except for indolepropionic acid, the concentrations of tryptophan metabolites were significantly higher in umbilical foetal plasma than in maternal plasma. In addition, 3-hydroxyanthranilic acid was present in umbilical foetal blood, but not in maternal blood. Furthermore, kynurenic acid was also detected in amniotic fluids.
authors.affiliation: Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Morita
authors.forename: M
authors.initials: M
authors.lastname: Kawamoto
authors.forename: H
authors.initials: H
authors.lastname: Yoshida
mesh_terms: D000596:Amino Acids / Q000097:blood; D000653:Amniotic Fluid / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005333:Fetus / Q000378:metabolism*; D006801:Humans; D007202:Indicators and Reagents; D007231:Infant, Newborn; D011247:Pregnancy; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D014364:Tryptophan / Q000097:blood*
chemical_list: D000596:Amino Acids; D007202:Indicators and Reagents; D014364:Tryptophan