title: [The effect of chronic gamma irradiation in an exponentially decreasing dose rate on the nucleic acid content in the hematopoietic organs and blood of rats].
abstract: The effect of continuous gamma irradiation at exponentially decreased dose rates (from 562 mGy/h to 13 mGy/h with a total cumulative dose of 14.355 Gy delivered over a period of 10 days) on the nucleic acid content of rat hemopoietic tissues and blood was followed up. The radiation model used simulated a decrease in the radioactivity of a fission mixture in the contaminated environment resulting from a nuclear device accident. We have found that the dynamics of the changes seems to be similar to that observed after acute exposure, and the hemopoiesis recovery starts just at the time of irradiation. In evaluating the damage and recovery extent after accidental irradiation, we consider it expedient to complement the biological dosimetry with the indices studied work including the determination of DNA and RNA concentrations in blood of irradiated human beings.
authors.affiliation: Department of Cellular and Molecular Biology, P. J. Safárik University, Kosice, Czechoslovakia.
authors.forename: E
authors.initials: E
authors.lastname: Misurová
authors.forename: K
authors.initials: K
authors.lastname: Kropácová
authors.forename: R
authors.initials: R
authors.lastname: Rexa
mesh_terms: D000818:Animals; D001769:Blood / Q000528:radiation effects*; D001835:Body Weight / Q000528:radiation effects; D002908:Chronic Disease; D004247:DNA / Q000032:analysis / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006413:Hematopoietic System / Q000737:chemistry / Q000528:radiation effects*; D008297:Male; D012313:RNA / Q000032:analysis / Q000528:radiation effects*; D011833:Radiation Injuries, Experimental / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D012313:RNA; D004247:DNA