Old microbes with new faces: molecular biology and the design of new vaccines.
Rational approaches to the design of live attenuated bacterial and viral recombinant vaccine strains are leading to the manipulation of old vaccines and the generation of new ones. The two basic problems to be solved are attenuation of pathogenic strains, and the stable expression of foreign antigens.
Connell
N
N
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 1046.
Stover
C K
CK
Jacobs
W R
WR
D000256:Adenoviridae / Q000276:immunology; D000818:Animals; D001428:Bacterial Vaccines / Q000096:biosynthesis; D008967:Molecular Biology; D014613:Vaccines, Attenuated / Q000096:biosynthesis*; D014614:Vaccines, Synthetic / Q000096:biosynthesis*; D014615:Vaccinia / Q000276:immunology; D014765:Viral Vaccines / Q000096:biosynthesis
D001428:Bacterial Vaccines; D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic; D014765:Viral Vaccines