Sticking coefficients of adsorbing proteins.
The protein sticking coefficient, phi, the fraction of collisions that result in adsorption, is a function of the molecular interactions between the protein and the surface. A random walk and diffusion-to-capture model was used to describe the kinetics of protein adsorption. The assumption of a constant sticking coefficient leads to a first-order model of the kinetics. A solution of the problem of adsorption from a semi-infinite medium with first-order kinetics at the boundary was obtained by numerical simulation on the computer. The results of the computer simulations match the time dependence observed experimentally. A correlation was developed to estimate phi from experimental data. phi has been found to be in the range 10(-5)-10(-8) for several protein adsorption kinetic studies reported in the literature.
Weaver
D R
DR
Department of Chemical Engineering, Brigham Young University, Provo, Utah 84602.
Pitt
W G
WG
D000327:Adsorption; D004058:Diffusion; D008432:Mathematical Computing; D008956:Models, Chemical; D011506:Proteins / Q000737:chemistry / Q000493:pharmacokinetics*
D011506:Proteins