Brain implants in man do not break down the blood-brain barrier to dopamine and domperidone.
We have evaluated the blood-brain barrier (BBB) in 8 Parkinsonian patients before and after stereotactic implantation of foetal mesencephalon (STIM) and one patient with an adrenal medullary implant. Parenteral administration of dopamine did not reverse Parkinsonism pre-operatively or at 5 days, 1, 2, 3, 4 months and 1 year post-operatively. Apomorphine and domperidone reversed Parkinsonism and produced dyskinesia in all patients pre- and post-operatively. We conclude that the BBB remains intact to dopamine following implantation.
Clough
C G
CG
Department of Neurosurgery, University of Birmingham, Midland Centre for Neurosurgery and Neurology, Smethwick, Warley, UK.
Hitchcock
E R
ER
Hughes
R C
RC
Henderson
B T
BT
Kenny
B G
BG
D000328:Adult; D000368:Aged; D001058:Apomorphine / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism*; D004294:Domperidone / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D004298:Dopamine / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D004343:Drug Implants; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000378:metabolism
D004343:Drug Implants; D004294:Domperidone; D001058:Apomorphine; D004298:Dopamine