Clarithromycin-ciprofloxacin-amikacin for therapy of Mycobacterium avium-Mycobacterium intracellulare bacteremia in patients with AIDS.
A combination of clarithromycin, ciprofloxacin, and amikacin for the treatment of Mycobacterium avium-Mycobacterium intracellulare bacteremia was evaluated in 12 AIDS patients. Mycobacteremia cleared in all patients by 2 to 8 weeks of treatment, and symptoms resolved. Four patients died; all had negative blood cultures until death, and disseminated M. avium-M. intracellulare complex infection was not considered the primary cause of death.
de Lalla
F
F
Department of Infectious Diseases, S. Bortolo Hospital, Vicenza, Italy.
Maserati
R
R
Scarpellini
P
P
Marone
P
P
Nicolin
R
R
Caccamo
F
F
Rigoli
R
R
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000583:Amikacin / Q000008:administration & dosage / Q000627:therapeutic use*; D016470:Bacteremia / Q000150:complications / Q000188:drug therapy*; D002423:Cause of Death; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D017291:Clarithromycin; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004917:Erythromycin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D015270:Mycobacterium avium-intracellulare Infection / Q000150:complications / Q000188:drug therapy*; D010865:Pilot Projects
D002939:Ciprofloxacin; D004917:Erythromycin; D000583:Amikacin; D017291:Clarithromycin