title: Ti gamma A + delta TCS1+ T cells in human thymus. Analysis of the T cell receptor.
abstract: TcR1+ T cells in peripheral blood have been shown to express in an exclusive fashion either the Ti gamma A or the delta TCS1 epitope. Here, we characterize a subset of TcR1+ T cells in fresh thymus co-expressing the Ti gamma A and delta TCS1 epitopes. TcR1dim and TcR1bright clones can be distinguished. Biochemical and molecular studies on both types of clones generated from these thymocytes reveal a unique T cell receptor structure characterized by the use of a V gamma 9/C gamma 2-encoded 55-kDa gamma chain nondisulfide linked to a V delta 1-encoded delta chain.
authors.affiliation: Abteilung Immunologie und Transfusionsmedizin, Medizinische Hochschule, Hannover, FRG.
authors.forename: R
authors.initials: R
authors.lastname: Bosse
authors.forename: H
authors.initials: H
authors.lastname: Heiken
authors.forename: W
authors.initials: W
authors.lastname: Kolanus
authors.forename: P
authors.initials: P
authors.lastname: Delany
authors.forename: F
authors.initials: F
authors.lastname: Triebel
authors.forename: R E
authors.initials: RE
authors.lastname: Schmidt
mesh_terms: D002460:Cell Line; D004220:Disulfides / Q000032:analysis; D006801:Humans; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology*
chemical_list: D004220:Disulfides; D016692:Receptors, Antigen, T-Cell, gamma-delta