title: Sequence comparison between the phosphoprotein mRNAs of human and bovine respiratory syncytial viruses identifies a divergent domain in the predicted protein.
abstract: The nucleotide and deduced amino acid sequences of the phosphoprotein (P) mRNA of bovine respiratory syncytial virus (BRSV) strain A51908 have been determined. The P mRNA is 860 nucleotides long with a single large open reading frame and the encoded polypeptide is 241 amino acids long. Comparison with the corresponding sequences of human respiratory syncytial virus (HRSV) subgroups A and B revealed 72 to 74% identity at the nucleotide level, and 81% at the amino acid level. The P protein contains a single divergent domain (37% amino acid identity) flanked by highly conserved domains (87% amino acid identity). The 3' end non-coding region is 47 nucleotides shorter than the corresponding region of HRSV. Comparison of the P mRNA sequences of two strains of BRSV (A51908 and FS-1) showed that there was extensive sequence identity at both the nucleotide (97%) and amino acid (97.9%) levels.
authors.affiliation: College of Veterinary Medicine, University of Maryland, College Park 20742.
authors.forename: S K
authors.initials: SK
authors.lastname: Mallipeddi
authors.forename: S K
authors.initials: SK
authors.lastname: Samal
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000956:Antigens, Viral / Q000235:genetics; D001483:Base Sequence; D002417:Cattle; D014644:Genetic Variation; D015707:HN Protein; D006801:Humans; D008969:Molecular Sequence Data; D010750:Phosphoproteins / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics*; D012136:Respiratory Syncytial Viruses / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D014759:Viral Envelope Proteins; D014764:Viral Proteins / Q000235:genetics*
chemical_list: D000956:Antigens, Viral; D015707:HN Protein; D010750:Phosphoproteins; D012333:RNA, Messenger; D014759:Viral Envelope Proteins; D014764:Viral Proteins; C116204:attachment protein G