[Serum antibodies to brain protein antigens in cerebral palsy in children].
Using special brain antigen test-system ELITEST-24, ELISA assays of the serum of children with cerebral palsy were conducted. The data obtained were compared to relevant characteristics of the sera from neurologically and somatically healthy persons and patients with diagnoses of multiple sclerosis, schizophrenia, epilepsy and hepato-cerebral dystrophy according to special PC program VIZUAL and DIAGNOST. High specificity of the cerebral palsy anti-brain antigens reactivity was revealed by ELITEST technique. Moreover, the comparison of the mother-child pair immunoreactivity has been conducted. Evidence for hypothesis of epigenetically performing of children antibodies repertoires by mother-during-pregnancy immune status were obtained. Possible immunopathologic mechanisms of the disease are discussed.
Rubtsova
M Iu
MIu
Lobanov
D S
DS
Kloss
T Iu
TIu
Semenov
A S
AS
Poletaev
A B
AB
D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D001324:Autoantigens / Q000276:immunology*; D001921:Brain / Q000276:immunology*; D002547:Cerebral Palsy / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D007525:Isoelectric Focusing; D009419:Nerve Tissue Proteins / Q000276:immunology*
D001323:Autoantibodies; D001324:Autoantigens; D009419:Nerve Tissue Proteins