Plasma membrane redox activity correlates with N-myc expression in neuroblastoma cells.
In different neuroblastoma cell lines and transfected clones, an increasing plasma membrane redox activity correlates with amplification and enhanced expression of the N-myc oncogene. Furthermore, plasma membrane redox activity is partially inhibited by retinoic acid in neuroblastoma cells with multiple copies of the N-myc oncogene but not in neuroblastoma cells with only one copy of this gene.
Medina
M A
MA
Sektion Onkologie/Immunologie, Ruprecht-Karls-Universität, Heidelberg, Germany.
del Castillo-Olivares
A
A
Schweigerer
L
L
D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology; D005784:Gene Amplification; D016259:Genes, myc; D006801:Humans; D009447:Neuroblastoma / Q000235:genetics* / Q000378:metabolism; D010084:Oxidation-Reduction; D014162:Transfection; D014212:Tretinoin / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D016222:Fibroblast Growth Factor 2; D014212:Tretinoin