An exceptional case of lethal disulfiram-alcohol reaction.
A case of fatal disulfiram-alcohol reaction due to ingestion of ethanol and antabuse is presented. Unusual autopsy findings and toxicological results are described. This case represents a report of corrosion lesion in the lower oesophagus and stomach due to a violent chemical reaction in situ and also the highest blood concentration of acetaldehyde (41 mg/l) ever recorded.
Heath
M J
MJ
Department of Forensic Medicine, London Hospital Medical College, UK.
Pachar
J V
JV
Perez Martinez
A L
AL
Toseland
P A
PA
D000434:Alcoholic Beverages / Q000009:adverse effects*; D000437:Alcoholism / Q000188:drug therapy; D000447:Aldehydes / Q000032:analysis; D004221:Disulfiram / Q000506:poisoning* / Q000627:therapeutic use; D004347:Drug Interactions; D004947:Esophagus / Q000737:chemistry / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011041:Poisoning / Q000378:metabolism / Q000473:pathology; D013270:Stomach / Q000737:chemistry / Q000473:pathology
D000447:Aldehydes; D004221:Disulfiram