Investigations of the acute toxic, cytogenetic, and embryotoxic activity of buminafos.
The organophosphorus herbicide buminafos (O,O-dibutyl-(1-butylaminocyclohexyl)-phosphonate) was tested for its acute toxic, cytogenetic, and embryotoxic activity on different strains of mice. The oral LD50 value for male NMRI mice was determined to be 3500 mg/kg. Single oral doses of 175, 1000, and 2000 mg/kg did not cause any significant enhancement in the percentage of chromosome aberrations in bone marrow cells of male NMRI mice. After oral administration of 500 and 1000 mg/kg buminafos to pregnant Halle:DBA and Halle:AB mice at Days 6-15 of gestation no embryotoxic effects were observed. The cytogenetic inactivity of buminafos in the bone marrow chromosome assay corresponds to negative findings in other mutagenicity tests.
Nehéz
M
M
Department of Hygiene and Epidemiology, Albert Szent-Györgyi University Medical School, Szeged, Hungary.
Fischer
G W
GW
Scheufler
H
H
Schmidt
R
R
Sipos
T
T
Dési
I
I
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations; D005260:Female; D006540:Herbicides / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009153:Mutagens / Q000633:toxicity*; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000633:toxicity*; D011247:Pregnancy; D013723:Teratogens / Q000633:toxicity*
D006540:Herbicides; D009153:Mutagens; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D013723:Teratogens; C078045:buminafos