Antimutagenic effects of polyphenolic compounds.
Smokers expose themselves to potent carcinogens daily. One of them is the nicotine-derived nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Since estimates are that humans consume 1 g of phenolic compounds/day, we investigated the inhibitory effects of five structurally related polyphenolic compounds on the mutagenicity of NNK in Salmonella typhimurium TA1535. NNK at a concentration of 80 mM was activated by hamster liver microsomes. The antimutagenic efficacies were dose-related between the non-toxic concentrations of 0.1 and 0.5 mmol/dish in the following order: esculetin > ellagic acid > (+)-catechin > propyl gallate > (-)esculin. At the highest non-toxic dose tested (0.5 mmol/dish), these polyphenolics inhibited mutagenesis in TA1535 by 77%, 67%, 62%, 59% and 53%, respectively. The results of this study demonstrated that polyphenolic compounds may inhibit the activation of NNK.
Teel
R W
RW
Department of Physiology and Pharmacology, School of Medicine, Loma Linda University, CA 92350.
Castonguay
A
A
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001711:Biotransformation; D006224:Cricetinae; D008297:Male; D008647:Mesocricetus; D009152:Mutagenicity Tests; D009602:Nitrosamines / Q000378:metabolism; D010636:Phenols / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects
D016587:Antimutagenic Agents; D009602:Nitrosamines; D010636:Phenols; C016583:4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone