Identification of a 5-HT1A receptor positively coupled to planarian adenylate cyclase.
The adenylate cyclase system present in particulate fractions prepared from two planarian species was tested for sensitivity to various neurotransmitters. While dopamine and other catecholamines were ineffective, serotonin was capable of stimulating the enzyme. Among the various serotonin agonists tested, only 8-OH-DPAT resulted effective on the adenylate cyclase activity, thus suggesting the presence in planarians of a serotonin receptor of the type 5-HT1A.
Cretì
P
P
Department of Biology, University of Lecce, Italy.
Capasso
A
A
Grasso
M
M
Parisi
E
E
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D010986:Platyhelminths / Q000201:enzymology*; D011985:Receptors, Serotonin / Q000032:analysis* / Q000187:drug effects; D015290:Second Messenger Systems / Q000187:drug effects*; D012701:Serotonin / Q000502:physiology*; D013045:Species Specificity; D013764:Tetrahydronaphthalenes / Q000494:pharmacology
D011985:Receptors, Serotonin; D013764:Tetrahydronaphthalenes; D012701:Serotonin; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000262:Adenylyl Cyclases; D004298:Dopamine