Tumor angiogenesis: evidence of new blood channels from plasma infiltrations.
Stroma formation in Ehrlich carcinoma, studied with histochemical and TEM techniques, is similar to wound healing. In this tumour mast cells, macrophages, adipocytes, platelets and fibrin seem to co-operate locally with malignant cells in regulating stroma formation. The gaps opened in the tumor parenchyma by plasma outpouring from local blood vessels seem to offer easy routes for endothelial cell migration towards ill-nourished areas, and may explain the irregular aspect of tumor microvascularity.
Freitas
I
I
Department of Animal Biology, University of Pavia, Italy.
Baronzio
G F
GF
Barni
S
S
Bertone
V
V
Griffini
P
P
Accossato
P
P
Pontiggia
P
P
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000098:blood supply* / Q000473:pathology; D004487:Edema / Q000473:pathology / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000473:pathology / Q000648:ultrastructure; D051379:Mice; D008833:Microcirculation / Q000473:pathology / Q000648:ultrastructure; D008854:Microscopy, Electron; D009389:Neovascularization, Pathologic / Q000473:pathology* / Q000503:physiopathology; D014945:Wound Healing