Influence of phenobarbital and triiodothyronine on the development of hepatic eosine transport in rats.
In male Wistar rats aged 20 and 60 days the influence of a 5-day-treatment with phenobarbital (PB, 75 mg/kg b.m. i.p.), triiodothyronine (T3, 100 micrograms/kg b.m. s.c.) and both agents simultaneously (PB+T3) on eosine accumulation of liver slices in vitro and biliary excretion of eosine in vivo was investigated. PB enhanced bile acid independent bile flow. T3 accelerated eosine accumulation in liver slices. The combined treatment with PB+T3 had no additional effects. The simultaneous action of PB+T3 could not induce the maturation of the rate limiting excretion process for organic anions in 20-day-old rats.
Barth
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Institute of Pharmacology and Toxicology, Friedrich Schiller University, Jena, Germany.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects / Q000502:physiology; D004801:Eosine Yellowish-(YS) / Q000493:pharmacokinetics*; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D008099:Liver / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D008297:Male; D010634:Phenobarbital / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014284:Triiodothyronine / Q000008:administration & dosage / Q000494:pharmacology*
D014284:Triiodothyronine; D004801:Eosine Yellowish-(YS); D010634:Phenobarbital