Hyperglucagonemia induced in mice by tryptamine: involvement of the peripheral 5-HT2 receptors.
The effects of an indoleamine, tryptamine, on plasma glucagon levels were investigated in mice. Tryptamine induced dose-related increases in plasma glucagon levels. The hyperglucagonemia effects of tryptamine were completely antagonized by methysergide and ketanserin which have a high affinity to 5-HT2 receptors. In addition, the peripheral 5-HT2 receptor antagonist, xylamidine, also strongly inhibited tryptamine-induced hyperglucagonemia. Our results indicate that the peripheral 5-HT2 receptors mediate the increase in plasma glucagon levels induced by tryptamine and that these receptors may have a role in the control of glucagon secretion.
Yamada
J
J
Department of Pharmacology, Kobe Women's College of Pharmacy, Japan.
Sugimoto
Y
Y
Kimura
I
I
Watanabe
Y
Y
Takeuchi
N
N
Horisaka
K
K
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005934:Glucagon / Q000097:blood*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000494:pharmacology; D014363:Tryptamines / Q000494:pharmacology*
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D014363:Tryptamines; C030820:tryptamine; D005934:Glucagon