Autoimmunity and the ovary.
The ovary was first documented as a target of autoimmunity over three decades ago yet today the aetiology and pathogenesis of autoimmune-mediated premature ovarian failure (POF) are poorly understood. Here, Roy and Helga Moncayo provide a brief overview of human autoimmune-mediated POF and the animal models of POF. They propose a model for the development of the disease, highlighting the role of supraphysiological levels of gonadotropins in inducing selectively antigenic mature ovarian elements.
Moncayo
R
R
Dept of Nuclear Medicine, University of Innsbruck, Austria.
Moncayo
H E
HE
D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D016572:Cyclosporine / Q000633:toxicity; D004195:Disease Models, Animal; D004351:Drug Resistance; D005260:Female; D006065:Gonadotropins, Pituitary / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007114:Immunization; D008594:Menopause, Premature / Q000276:immunology*; D051379:Mice; D008819:Mice, Nude; D010053:Ovary / Q000187:drug effects / Q000276:immunology*; D010062:Ovulation Induction / Q000009:adverse effects; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013934:Thymectomy / Q000009:adverse effects; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology
D001323:Autoantibodies; D006065:Gonadotropins, Pituitary; D016572:Cyclosporine