Behaviour of several 'progression markers' during the HIV-Ab seroconversion period. Comparison with later stages.
Two acute phase reactants, four cytokines, five soluble factors and lymphocyte subpopulations have been simultaneously evaluated in 16 subjects before and closely after the HIV-Ab seroconversion time. The same variables have also been determined in 50 HIV-Ab-negative high risk subjects, in 36 CDC II-III and in 30 CDC IV patients, utilizing a mixed longitudinal epidemiological model. The results show significant variations of few parameters in the early phases (increase: sCD8, beta-2-Microglobulin, sIL-2R, sCD23, Neopterin, IFN-alpha; decrease: CD4+ lymphocytes). In the course of the disease, many others parameters progressively increase (IFN-tau, IL-4, IL-6, acid-alpha 1-glycoprotein, alpha 1-antitrypsin) or decrease (B- and T-lymphocytes). Ferritin, in particular, highly increases only in CDC IV stage. These data may be useful to monitor patients during the entire course of their disease and to suggest the time elapsed from seroconversion.
Cordiali Fei
P
P
Laboratory of Clinical Pathology, San Gallicano Institute, Roma, Italy.
Massa
A
A
Prignano
G
G
Pietravalle
M
M
Alemanno
L
L
Vitelli
G
G
Palamara
G
G
Giglio
A
A
Gandolfo
G M
GM
Gentili
G
G
D000209:Acute-Phase Proteins / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood*; D001708:Biopterins / Q000031:analogs & derivatives / Q000097:blood; D016207:Cytokines / Q000097:blood; D006679:HIV Seropositivity / Q000097:blood* / Q000276:immunology; D006801:Humans; D016131:Lymphocyte Subsets / Q000276:immunology; D008297:Male; D019798:Neopterin; D013997:Time Factors
D000209:Acute-Phase Proteins; D015415:Biomarkers; D016207:Cytokines; D001708:Biopterins; D019798:Neopterin