title: Morphological changes in diseased gall bladder: a study of 415 cholecystectomies at Aligarh.
abstract: Morphological changes of gall bladder were studied in 415 cholecystectomy specimens. There was a preponderance of females (male to female ratio--1:6.5). The mean age of the cases was 43.6 years. Most of the cases (63.4%) were in the 4th and 5th decades of life. The average duration of illness was 2.8 years. Associated cholelithiasis was present in 85.3% cases. Gall-stones were of mixed variety in 78.2% cases, cholesterol type in 15.3% cases and both types were present in 6.5% cases. Chronic cholecystitis was the main histological diagnosis (50.8%). Other lesions observed were adenomyomatosis (8.2%), adenomatous hyperplasia (10.1%), granulomatous cholecystitis (4.1%), cholesterosis (2.7%), acute cholecystitis (4.1%), acute on chronic infection (10.8%), sub-acute cholecystitis (2.4%) and carcinoma gall bladder (6.8%). The frequency of Rokitansky-Aschoff's sinuses was closely related with the degree of inflammatory response. In 13 (6.2%) cases the diagnosis of chronic follicular cholecystitis was made. All the cases of cholesterosis were multiparous females and of younger age. Of the malignant lesions, adenocarcinoma was the commonest (96.4%).
authors.affiliation: Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim University.
authors.forename: S P
authors.initials: SP
authors.lastname: Tyagi
authors.forename: N
authors.initials: N
authors.lastname: Tyagi
authors.forename: V
authors.initials: V
authors.lastname: Maheshwari
authors.forename: S M
authors.initials: SM
authors.lastname: Ashraf
authors.forename: P
authors.initials: P
authors.lastname: Sahoo
mesh_terms: D000328:Adult; D002763:Cholecystectomy; D005260:Female; D005705:Gallbladder Diseases / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012737:Sex Factors