[A study on the role of immunosuppression in the pathogenesis of brucellosis].
An immunosuppressive effect was seen in murine brucellosis as detected by using plaque forming cell (PFC) and 3H-labelled lymphocyte blastogenesis transformation (LBT) assays. The immunosuppression PFC could last until 11 months after infection, while that of LBT was only seen at 3 months after infection. This immunosuppression could be relieved by using immunomodulators such as levamisole, bestatin, IL-2 and polyporus umbellatus. IL-2 and polyporus umbellatus could reverse the suppression to normal levels. Thus, this study provided evidence that immunosuppression is a component of pathogenesis of brucellosis.
Zhang
J
J
Institute of Epidemiology & Microbiology, Chinese Academy of Preventive Medicine, Beijing.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D002006:Brucellosis / Q000209:etiology / Q000276:immunology*; D006462:Hemolytic Plaque Technique; D007108:Immune Tolerance; D007376:Interleukin-2 / Q000494:pharmacology; D007930:Leucine / Q000031:analogs & derivatives / Q000494:pharmacology; D007978:Levamisole / Q000494:pharmacology; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL
D000276:Adjuvants, Immunologic; D007376:Interleukin-2; D007978:Levamisole; D007930:Leucine; C012211:ubenimex