Surgery for disseminated abdominal sarcoma.
Seventy-two consecutive patients with disseminated soft tissue sarcoma in the abdomen were prospectively placed in a program of debulking surgery. The tumor was completely resectable in 64% of the patients. Following the first exploration, the median survival was 23 months for those with resection of metastases and 9 months for those without resection (p less than or equal to 0.01); the former group had a survival rate of 28% at 3 years, 18% at 4 years, and 4% at 5 years (44%, 37%, and 10%, respectively, for low-grade sarcomas, i.e., grade I or II sarcomas), whereas in the latter group, none survived for 3 years. In the group with resection, patients with grade III tumors had a median survival longer by 6 months, and those with low-grade tumors by 28 months (p less than or equal to 0.001), over the respective median survival of patients with unresectable tumors. Metastasectomy appeared to prolong survival in all patients and significantly so in patients with low-grade tumors and those with long disease-free intervals.
Karakousis
C P
CP
Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263.
Blumenson
L E
LE
Canavese
G
G
Rao
U
U
D000008:Abdominal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007890:Leiomyosarcoma / Q000601:surgery; D008080:Liposarcoma / Q000601:surgery; D008113:Liver Neoplasms / Q000556:secondary / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D010534:Peritoneal Neoplasms / Q000601:surgery; D011446:Prospective Studies; D012186:Retroperitoneal Neoplasms / Q000601:surgery; D012509:Sarcoma / Q000188:drug therapy / Q000473:pathology / Q000556:secondary / Q000601:surgery*; D015996:Survival Rate