title: Teicoplanin--its role as systemic therapy of burn infections and as prophylaxis for orthopaedic surgery. Italian Study Groups for Antimicrobial Prophylaxis in Orthopaedic Surgery and Burns.
abstract: Two randomized studies have been initiated to establish the role of teicoplanin as systemic therapy for infections in burns patients and as short-term prophylaxis for orthopaedic implant surgery. Opportunistic micro-organisms causing infections in burn patients are often acquired in hospital. These infections commonly involve Gram-positive organisms which may be resistant to several antibiotics. Teicoplanin, alone and in combination with additional antibacterial drugs, is effective in the treatment of Gram-positive infections of various types. In addition, teicoplanin has proved useful as prophylaxis against infection in orthopaedic surgery. Deep prosthetic infections are very difficult to cure without removing the infected device; the outcome can be devastating, such as total loss of joint function, amputation, and, occasionally, death. Preliminary results from the two studies are encouraging and show that teicoplanin has a role to play both in treatment of infection and as prophylaxis against hospital-acquired infection.
authors.affiliation: Dipartimento di Farmacologia, Università degli Studi, Firenze, Italia.
authors.forename: P
authors.initials: P
authors.lastname: Periti
authors.forename: G
authors.initials: G
authors.lastname: Stringa
authors.forename: L
authors.initials: L
authors.lastname: Donati
authors.forename: T
authors.initials: T
authors.lastname: Mazzei
authors.forename: E
authors.initials: E
authors.lastname: Mini
authors.forename: A
authors.initials: A
authors.lastname: Novelli
mesh_terms: D000328:Adult; D002056:Burns / Q000150:complications*; D002437:Cefazolin / Q000627:therapeutic use; D003428:Cross Infection / Q000517:prevention & control; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D005260:Female; D006020:Glycopeptides / Q000627:therapeutic use; D016908:Gram-Positive Bacterial Infections / Q000517:prevention & control*; D006801:Humans; D007595:Joint Prosthesis; D008297:Male; D008875:Middle Aged; D009428:Netilmicin / Q000627:therapeutic use; D011183:Postoperative Complications / Q000517:prevention & control*; D017334:Teicoplanin; D013949:Thymus Extracts / Q000627:therapeutic use; D014946:Wound Infection / Q000517:prevention & control*
chemical_list: D006020:Glycopeptides; D013949:Thymus Extracts; C031407:thymostimulin; D009428:Netilmicin; D017334:Teicoplanin; D002437:Cefazolin