title: Fragile X positivity in Chinese children with autistic spectrum disorder.
abstract: Chromosome analysis was performed in 105 Chinese children (96 boys, 9 girls) with autistic spectrum disorder to assess fragile X positivity. Seventy percent of these autistic children were mentally retarded. None of the children in the infantile autism group (N = 75) had fragile X positivity. Two boys in the autistic condition group (N = 30) had clinical features and chromosomal positivity for fragile X syndrome. The low (2%) prevalence rate of fragile X positivity in children with different degrees of expressivity of autistic features may be related to other factors rather than to pure autistic characteristics per se.
authors.affiliation: Department of Paediatrics, University of Hong Kong, Pokfulam.
authors.forename: V C
authors.initials: VC
authors.lastname: Wong
authors.forename: S T
authors.initials: ST
authors.lastname: Lam
mesh_terms: D001321:Autistic Disorder / Q000175:diagnosis / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005600:Fragile X Syndrome / Q000175:diagnosis / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D006723:Hong Kong; D006801:Humans; D007223:Infant; D008607:Intellectual Disability / Q000175:diagnosis / Q000235:genetics; D008297:Male
chemical_list: D005819:Genetic Markers