title: Evidence for pulsatile secretion of human atrial natriuretic peptide in healthy subjects.
abstract: The secretion pattern of human atrial natriuretic peptide (hANP) was investigated in 8 healthy male volunteers. Blood was drawn in 2 minute intervals for 90 minutes and in a second study in 4 minute intervals for 180 minutes. Base-line hANP plasma levels varied in a pulsatile secretion pattern of regular pulses every 9 +/- 1 minutes. Additionally long-term oscillations of 34 +/- 4 minutes were found. These data suggest that under basal conditions hANP varies in a pulsatile fashion.
authors.affiliation: Department of Endocrinology, Johann Wolfgang Goethe-University, Frankfurt am Main/Germany.
authors.forename: T
authors.initials: T
authors.lastname: Haak
authors.forename: E
authors.initials: E
authors.lastname: Jungmann
authors.forename: K
authors.initials: K
authors.lastname: Schöffling
authors.forename: K H
authors.initials: KH
authors.lastname: Usadel
mesh_terms: D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood* / Q000378:metabolism; D006321:Heart / Q000502:physiology; D006801:Humans; D008297:Male; D009206:Myocardium / Q000378:metabolism; D011673:Pulsatile Flow / Q000502:physiology*; D013997:Time Factors
chemical_list: D009320:Atrial Natriuretic Factor