Mental and physical state in subclinical hyperthyroidism: investigations in a normal working population.
We investigated whether subclinically hyperthyroid individuals selected from a nonpatient working population exhibit similar impairments to those found in studies with patients. Sixteen subclinically hyperthyroid subjects without apparent reason (SH-0) and 15 subclinically hyperthyroid subjects on levothyroxine (SH-T4) were compared with 27 euthyroid controls with respect to signs and symptoms of hyperthyroidism, sleep, depressivity, ability to concentrate, anxiety, and other dimensions of well-being. We found that SH-T4 exhibited significantly higher TT4 levels, TT4/TBG ratios, and more palpitations than controls. Furthermore, they slept less. The SH-0 subjects reported being in a better mood and less touchy than controls. Psychometric results of all groups were within the normal range. A comparison of this study to previous studies reveals that TT4 levels or TT4/TBG ratios may play a crucial role in the development of the predominantly nervous symptoms in subclinical hyperthyroidism. Possible reasons for the discrepancies between results in hospital and nonhospital settings are discussed.
Schlote
B
B
Berufsgenossenschaft für Nährungsmittel und Gaststätten (Social Corporation of Food and Catering) Mannheim, Germany.
Schaaf
L
L
Schmidt
R
R
Pohl
T
T
Vardarli
I
I
Schiebeler
H
H
Zober
M A
MA
Usadel
K H
KH
D000328:Adult; D001143:Arousal / Q000502:physiology; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000175:diagnosis / Q000517:prevention & control* / Q000523:psychology; D008297:Male; D008403:Mass Screening; D019965:Neurocognitive Disorders / Q000175:diagnosis / Q000523:psychology; D010555:Personality Inventory; D012803:Sick Role; D012894:Sleep Stages / Q000502:physiology; D013963:Thyroid Hormones / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone
D013963:Thyroid Hormones; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin