title: Oral lesions in systemic lupus erythematosus. Do ulcerative lesions represent a necrotizing vasculitis?
abstract: BACKGROUND
  It has been suggested that oral lesions in patients with systemic lupus erythematosus (SLE) may be grouped clinically as erythema, discoid lesions, or oral ulcerations. Oral ulcerations have been said to foretell a severe systemic disease flare and the proposal that oral ulcers represent a mucosal vasculitis has been suggested to explain this hypothesis.
  
  
  OBJECTIVE
  Our objective was to test the hypothesis that oral ulcers in patients with SLE result from vasculitis.
  
  
  METHODS
  We studied 10 patients with American College of Rheumatology (ACR) criteria for a diagnosis of SLE who had oral lesions of lupus (six prospectively and four retrospectively) clinically and by routine and immunofluorescence microscopy. Biopsy specimens were reviewed in a single-blinded fashion.
  
  
  RESULTS
  In our patients, no oral lesion, regardless of morphology, demonstrated vasculitis histologically. All lesions demonstrated an interface mucositis.
  
  
  CONCLUSIONS
  Our data strongly contradict the hypothesis that leukocytoclastic vasculitis explains a possible unproven correlation between oral ulceration and disease flares in patients with SLE.
authors.affiliation: Department of Dermatology, Bowman Gray School of Medicine, Winston-Salem, NC 27157-1071.
authors.forename: J L
authors.initials: JL
authors.lastname: Jorizzo
authors.forename: P L
authors.initials: PL
authors.lastname: Salisbury
authors.forename: R S
authors.initials: RS
authors.lastname: Rogers
authors.forename: S M
authors.initials: SM
authors.lastname: Goldsmith
authors.forename: G G
authors.initials: GG
authors.lastname: Shar
authors.forename: J P
authors.initials: JP
authors.lastname: Callen
authors.forename: C M
authors.initials: CM
authors.lastname: Wise
authors.forename: E L
authors.initials: EL
authors.lastname: Semble
authors.forename: W L
authors.initials: WL
authors.lastname: White
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology*; D009336:Necrosis; D011446:Prospective Studies; D012189:Retrospective Studies; D013281:Stomatitis, Aphthous / Q000473:pathology*; D014657:Vasculitis / Q000473:pathology*