Penetration of ciprofloxacin into human peritoneal tissue following a single oral dose of 750 milligrams.
The penetration of ciprofloxacin into the peritoneal tissue was studied in 10 patients after a single oral dose of 750 mg given 5.6 hours (mean) before elective laparotomy. The mean tissue level was 0.29 micrograms/ml (range, 0.082 to 0.96 micrograms/ml) while the mean concomitant serum level was 1.3 micrograms/g (range, 0.52 to 2.57 micrograms/g). The achieved concentrations are above the minimum inhibitory concentrations (MICs) of ciprofloxacin for most gram-negative bacteria commonly involved in intra-abdominal infections.
Dan
M
M
Infectious Diseases Unit, Edith Wolfson Medical Center, Holon, Israel.
Serour
F
F
Poch
F
F
D000005:Abdomen; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000818:Animals; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006224:Cricetinae; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010537:Peritoneum / Q000502:physiology*
D002939:Ciprofloxacin