Measurements of T1 and T2 over time in formalin-fixed human whole-brain specimens.
T1 and T2 were measured in 5 formalin-fixed human whole-brain specimens as a function of time. Gray matter/white matter contrast reversal was observed around the 4th day and was considered to be due to the greater decrease in T1 in gray than in white matter. A possible explanation for this is that the decomposition of the myelin phospholipid structure by formalin somewhat counteracts the general reductive effect of the fixation procedure on relaxation times.
Tovi
M
M
Department of Diagnostic Radiology, Akademiska Sjukhuset, Uppsala University, Sweden.
Ericsson
A
A
D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology*; D005260:Female; D005557:Formaldehyde; D006801:Humans; D066298:In Vitro Techniques; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D016707:Tissue Fixation / Q000379:methods*
D005557:Formaldehyde