Lymphocytes in pseudomembranes of late prosthetic joint failure.
The pseudomembrane formed in association with late aseptic prosthesis failure contains a mixed giant cell and histiocytic infiltrate with variable numbers of lymphocytes. Immunolabelling with a panel of antibodies on paraffin sections was undertaken to define the nature of the lymphoid infiltrate in 19 cases. In all cases, the predominant lymphoid cell was a memory (CD45RO+, CD45RA-) T-cell. B-cells were rare. Tissue from patients with rheumatoid arthritis (RA) contained greater numbers of T-cells when compared with patients with osteoarthritis (OA), suggesting that the intensity of the lymphoid infiltrates reflects the underlying joint disease rather than necessarily being part of a hypersensitivity response to wear debris.
Salter
D M
DM
Department of Pathology, University of Edinburgh, U.K.
Krajewski
A S
AS
Robertson
S
S
D000368:Aged; D000941:Antigens / Q000032:analysis; D004868:Equipment Failure; D005260:Female; D006801:Humans; D007158:Immunologic Techniques; D007595:Joint Prosthesis; D007596:Joints / Q000276:immunology / Q000473:pathology*; D008214:Lymphocytes / Q000276:immunology / Q000473:pathology*; D008297:Male; D008566:Membranes / Q000276:immunology / Q000473:pathology; D008875:Middle Aged; D013194:Staining and Labeling; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
D000941:Antigens