[Effects of phenothiazine and dibenzazepine derivatives on the muscarinic cholinergic system].
Interactions of some dialkylaminoalkyl (DAL) and dialkylaminoacyl (DAC) derivatives of phenothiazine and dibenzazepine with muscarinic cholinergic receptors (MR) of rabbit striatum and heart and rat brain were investigated. DAC derivatives were more active at brain and heart MR in some cases. The most active preparation was G-512, DA-analogue of chlorpromazine. Some cardiotropic properties of antianginal preparation nonachlazine may be connected with its central antimuscarinic activity.
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D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects; D003342:Corpus Striatum / Q000187:drug effects; D003984:Dibenzazepines / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D010640:Phenothiazines / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D011976:Receptors, Muscarinic / Q000187:drug effects*
D000889:Anti-Arrhythmia Agents; D003984:Dibenzazepines; D010640:Phenothiazines; D011976:Receptors, Muscarinic