title: Modulation of inotropic therapy by venodilation in acute heart failure: a randomised comparison of four inotropic agents, alone and combined with isosorbide dinitrate.
abstract: The effects of four inotropic agents with differing ancillary properties [a cardiac glycoside (digoxin), a combined alpha- and beta-adrenergic agonist (dobutamine), a beta-adrenergic agonist (prenalterol), and a phosphodiesterase inhibitor (amrinone)] alone and with subsequent addition of isosorbide dinitrate were compared in 48 consecutive acute myocardial infarction patients with radiographic and haemodynamic (pulmonary artery occluded pressure greater than 18 mm Hg) left ventricular failure. All agents with the exception of dobutamine reduced the elevated left heart filling pressure; only digoxin and dobutamine augmented the cardiac stroke volume index. All drugs except digoxin reduced the SVRI; an arteriolar constrictor response was evident 60 min after digoxin and a tachycardia resulted after combined alpha- and beta- and beta-adrenergic stimulations (dobutamine and prenalterol, respectively). The addition of isosorbide dinitrate reversed the inotrope-induced elevations of systemic arterial pressure and resulted in additional reductions in left heart filling pressure. These data suggest that, in the absence of substantial venodilator properties in an inotropic compound, reduction in elevated left heart filling pressure is not achieved with inotropic therapy alone in acute left ventricular failure and combining a venodilator may be haemodynamically advantageous.
authors.affiliation: University Department of Cardiovascular Studies, General Infirmary, Leeds, U.K.
authors.forename: S P
authors.initials: SP
authors.lastname: Verma
authors.forename: B
authors.initials: B
authors.lastname: Silke
authors.forename: G W
authors.initials: GW
authors.lastname: Reynolds
authors.forename: A
authors.initials: A
authors.lastname: Richmond
authors.forename: S H
authors.initials: SH
authors.lastname: Taylor
mesh_terms: D000328:Adult; D000368:Aged; D000676:Amrinone / Q000627:therapeutic use; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D004077:Digoxin / Q000627:therapeutic use; D004280:Dobutamine / Q000627:therapeutic use; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007548:Isosorbide Dinitrate / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011294:Prenalterol / Q000627:therapeutic use; D011446:Prospective Studies; D016037:Single-Blind Method; D014664:Vasodilation / Q000502:physiology*
chemical_list: D002316:Cardiotonic Agents; D004280:Dobutamine; D004077:Digoxin; D007548:Isosorbide Dinitrate; D000676:Amrinone; D011294:Prenalterol