Effect of CD23 on purified human hematopoietic cells.
We report herein the effect of soluble CD23 (sCD23) on the differentiation of lymphoid and myeloid precursors. CD23 is known as the low affinity receptor for IgE. In addition to it, our results indicate that sCD23 in synergy with IL1 is able to promote the maturation of normal and leukemic hematopoietic progenitor cells.
Mossalayi
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D
Lab. Immunologie Cellulaire URA CNRS Pitie Salpetriere, France.
Dalloul
A
A
Arock
M
M
Debre
P
P
D000944:Antigens, Differentiation, B-Lymphocyte / Q000502:physiology*; D001853:Bone Marrow / Q000196:embryology; D001854:Bone Marrow Cells; D002454:Cell Differentiation / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000187:drug effects; D011961:Receptors, Fc / Q000502:physiology*; D017455:Receptors, IgE; D012995:Solubility; D013601:T-Lymphocytes / Q000166:cytology*; D013950:Thymus Gland / Q000166:cytology / Q000196:embryology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000944:Antigens, Differentiation, B-Lymphocyte; D011961:Receptors, Fc; D017455:Receptors, IgE