Lp(a): a link between thrombosis and atherosclerosis.
Lipoprotein(a), or Lp(a), is a lipoprotein having lipid composition similar to that of LDL, but a protein moiety consisting of ApoB 100 linked by disulfide bridge to apo(a), a glycoprotein with structural similarity to plasminogen. Lp(a) can be both atherogenic and thrombogenic. These two actions are likely to be mutually operative, a fact that on a molar basis makes Lp(a) more of a cardiovascular pathogen than LDL.
Scanu
A M
AM
Department of Medicine, Biochemistry and Molecular Biology, University of Chicago, Illinois 60637.
D000328:Adult; D001161:Arteriosclerosis / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy; D002648:Child; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage; D006801:Humans; D006951:Hyperlipoproteinemias / Q000150:complications* / Q000517:prevention & control / Q000628:therapy; D000960:Hypolipidemic Agents; D017270:Lipoprotein(a); D008074:Lipoproteins / Q000037:antagonists & inhibitors / Q000097:blood*; D008403:Mass Screening; D009355:Neomycin / Q000008:administration & dosage; D009525:Niacin / Q000008:administration & dosage; D012307:Risk Factors; D013927:Thrombosis / Q000178:diet therapy / Q000188:drug therapy / Q000209:etiology* / Q000517:prevention & control
D015525:Fatty Acids, Omega-3; D000960:Hypolipidemic Agents; D017270:Lipoprotein(a); D008074:Lipoproteins; D009525:Niacin; D009355:Neomycin