title: Individual differences in the cognitive and neurobiological consequences of normal aging.
abstract: Defining the neural basis of age-related cognitive dysfunction is a major goal of current research on aging. Compelling evidence from laboratory animals and humans indicates that aging does not inevitably lead to cognitive decline. Conducting neurobiological investigations in subjects that have previously undergone behavioral characterization has therefore emerged as a promising strategy for identifying those alterations in brain structure and function that are specifically associated with age-related cognitive impairment.
authors.affiliation: Laboratory of Neuronal Structure and Function, Salk Institute, San Diego, CA 92186-5800.
authors.forename: P R
authors.initials: PR
authors.lastname: Rapp
authors.forename: D G
authors.initials: DG
authors.lastname: Amaral
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D003071:Cognition / Q000502:physiology*; D006801:Humans; D007206:Individuality; D009424:Nervous System Physiological Phenomena