title: Effect of a bovine hemoglobin preparation (SBHS) on the response of two murine solid tumors to radiation therapy or chemotherapeutic alkylating agents.
abstract: When tested in mice bearing the Lewis lung tumor with 2, 3, or 4 Gy daily for 5 days, SBHS produced a dose-modifying factor of 1.6 that was increased to 2.1 with carbogen. The addition of SBHS (1.32 gm protein/kg) to treatment with melphalan (MEL) resulted in a 2.2-fold increase in the tumor growth delay (TGD). The combination of SBHS with carbogen (6 h) produced a 3.6-fold increase in TGD compared with MEL alone. The addition of SBHS to treatment with cyclophosphamide (CTX) resulted in a 2-fold increase in the TGD. However, the combination of SBHS and carbogen was much more effective resulting in a 4.6-fold increase in TGD. There was a 1.3-fold increase in TGD with SBHS and CDDP compared with CDDP alone. The combination of SBHS and carbogen was a more effective addition to CDDP resulting in a 1.9-fold increase in TGD. The addition of SBHS to treatment with BCNU increased the TGD produced by BCNU by 1.5-fold. The combination of SBHS/BCNU and carbogen resulted in a 2.3-fold increase in TGD over that obtained with BCNU alone.
authors.affiliation: Dana-Farber Cancer Institute, Boston, MA.
authors.forename: B A
authors.initials: BA
authors.lastname: Teicher
authors.forename: S A
authors.initials: SA
authors.lastname: Holden
authors.forename: G
authors.initials: G
authors.lastname: Ara
authors.forename: T S
authors.initials: TS
authors.lastname: Herman
authors.forename: R E
authors.initials: RE
authors.lastname: Hopkins
authors.forename: K
authors.initials: K
authors.lastname: Menon
mesh_terms: D000477:Alkylating Agents / Q000627:therapeutic use; D000818:Animals; D001802:Blood Substitutes / Q000302:isolation & purification / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006454:Hemoglobins / Q000302:isolation & purification / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*
chemical_list: D000477:Alkylating Agents; D001802:Blood Substitutes; D006454:Hemoglobins