title: Immunohistochemical localisation of substance P in human parotid gland.
abstract: Based on the clinical observation that pain is experienced during parotid gland surgery under local anaesthesia, the presence of the sensory neuropeptide substance P (SP) was sought. Using a polyclonal antibody, the presence of SP was demonstrated by an indirect immunofluorescence technique, with rat parotid gland and spinal cord serving as controls. SP-containing neuronal elements occurred around acini, blood vessels and ducts. It is suggested that some of the SP-immunoreactive elements are the unmyelinated and thinly myelinated small diameter (A delta and C) fibres, which are regarded as the peripheral receptors for nociceptive information.
authors.affiliation: Department of Oral Medicine, Faculty of Dentistry University of Otago, Dunedin, New Zealand.
authors.forename: B D
authors.initials: BD
authors.lastname: Whitley
authors.forename: J W
authors.initials: JW
authors.lastname: Ferguson
authors.forename: A J
authors.initials: AJ
authors.lastname: Harris
authors.forename: T B
authors.initials: TB
authors.lastname: Kardos
mesh_terms: D000273:Adipose Tissue / Q000294:innervation; D000328:Adult; D000818:Animals; D001808:Blood Vessels / Q000294:innervation; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D009412:Nerve Fibers / Q000737:chemistry*; D010306:Parotid Gland / Q000098:blood supply / Q000737:chemistry / Q000294:innervation*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000737:chemistry; D013373:Substance P / Q000032:analysis*; D013376:Substantia Gelatinosa / Q000737:chemistry
chemical_list: D013373:Substance P