Antigenic and genetic analyses of eight influenza C strains isolated in various areas of Japan during 1985-9.
Eight strains of influenza C virus isolated in various areas of Japan between January 1985 and January 1989 were compared using monoclonal antibodies to the haemagglutinin-esterase (HE) glycoproteins and by oligonucleotide mapping of total vRNA. Five of six strains isolated during 1986-9 were closely related to one another and also resembled the virus, C/Aichi/1/81, isolated in 1981 in Aichi prefecture. This suggests that the C/Aichi/1/81-related viruses had an epidemiological advantage over any co-circulating viruses at least during that period. One of two 1985 isolates (C/Nara/1/85) was antigenically indistinguishable from the C/Mississippi/1/80 strain though their oligonucleotide patterns were markedly different from each other. This raises the possibility that C/Nara/1/85 may be a recombinant virus which receives its HE gene from the C/Mississippi/1/80-related parent.
Ohyama
S
S
Yamagata Prefectural Institute of Public Health, Japan.
Adachi
K
K
Sugawara
K
K
Hongo
S
S
Nishimura
H
H
Kitame
F
F
Nakamura
K
K
D000956:Antigens, Viral / Q000032:analysis; D001483:Base Sequence; D000939:Epitopes / Q000032:analysis; D005814:Genes, Viral; D006389:Hemagglutinins, Viral / Q000235:genetics; D006801:Humans; D007251:Influenza, Human / Q000453:epidemiology / Q000382:microbiology*; D009982:Gammainfluenzavirus / Q000235:genetics* / Q000276:immunology* / Q000302:isolation & purification; D007564:Japan / Q000453:epidemiology; D009710:Nucleotide Mapping; D012367:RNA, Viral / Q000032:analysis; D014760:Viral Fusion Proteins; D014764:Viral Proteins / Q000235:genetics
D000956:Antigens, Viral; D000939:Epitopes; D006389:Hemagglutinins, Viral; D012367:RNA, Viral; D014760:Viral Fusion Proteins; D014764:Viral Proteins; C060814:hemagglutinin esterase