[Effects of concanavalin A on different variants of adhesive reactions of human neutrophils].
The influence of Con A on human neutrophils adhesion in interactions with sepharose 4B, C3b-sephadex G-25, DEAE-sephadex A-25, polymethylmethacrylate was studied. In concentrations 25 mg/ml and more Con A completely inhibited IgG-dependent adhesion but had no influence on other types of adhesion reactions. The effect was due to Con A interaction with neutrophils and could not be reproduced by Con A pretreatment of IgG-sepharose. Results are considered to be a manifestation of lectin-dependent modulation of cell receptors functions.
Chebotar'
I V
IV
Maianskiĭ
A N
AN
Solov'ev
K Iu
KIu
Chelyshev
I V
IV
D003208:Concanavalin A / Q000494:pharmacology*; D003911:Dextrans; D005782:Gels; D006801:Humans; D007202:Indicators and Reagents; D037102:Lectins; D008768:Methylmethacrylates; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D012685:Sepharose / Q000031:analogs & derivatives; D000267:Tissue Adhesions
D003911:Dextrans; D005782:Gels; D007202:Indicators and Reagents; D037102:Lectins; D008768:Methylmethacrylates; D011956:Receptors, Cell Surface; C036210:immunoglobulin G-sepharose; D003208:Concanavalin A; D012685:Sepharose; C025614:sephadex