title: A comparative study of the potentiating effect of caffeine and poly-D-lysine on chromosome damage induced by X-rays in plant cells.
abstract: X-Ray-induced chromosomal aberrations (CA) were potentiated by post-treatments in G2 with either caffeine (caff) or poly-D-lysine (PDL) in root-tip cells of Allium cepa. The enhancement of the yield of CA was concomitant with an increase in the frequency of mitosis. Our results seem to support the idea of a direct relationship between radiation-induced G2 delay and repair of chromosome damage. Here we report on similarities between caffeine and PDL in both decreasing G2 delay and enhancing chromatid aberration yield. The possible molecular mechanism(s) of action responsible for the cytogenetic effects observed are discussed.
authors.affiliation: Department of Cell Biology, Faculty of Biology, Sevilla, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Mateos
authors.forename: N
authors.initials: N
authors.lastname: Panneerselvam
authors.forename: J C
authors.initials: JC
authors.lastname: Mateos
authors.forename: F
authors.initials: F
authors.lastname: Cortés
mesh_terms: D002110:Caffeine / Q000633:toxicity*; D002869:Chromosome Aberrations; D004357:Drug Synergism; D016195:G2 Phase / Q000187:drug effects; D010944:Plants / Q000235:genetics; D011107:Polylysine / Q000633:toxicity*; D014965:X-Rays / Q000009:adverse effects
chemical_list: D011107:Polylysine; D002110:Caffeine