Activation of the Na+/K+/Cl- cotransport system by reorganization of the actin filaments in Ehrlich ascites tumor cells.
Reorganization (disassembly) of the actin filaments in Ehrlich ascites tumor cells, either by hypotonic treatment in the presence of Ca2+ or by addition of cytochalasin B, results in activation of the Na+/K+/Cl- cotransport system. However, other regulatory processes, some of which may be dependent on an intact filament system, are responsible for the activation of the Na+/K+/Cl- cotransport system after cell shrinkage.
Jessen
F
F
Technological Laboratory, Danish Ministry of Fisheries, Technical University, Lyngby.
Hoffmann
E K
EK
D000199:Actins / Q000502:physiology*; D000818:Animals; D001692:Biological Transport; D002034:Bumetanide / Q000494:pharmacology; D002286:Carcinoma, Ehrlich Tumor; D002352:Carrier Proteins / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism*; D003571:Cytochalasin B / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*; D028021:Sodium-Potassium-Chloride Symporters; D014407:Tumor Cells, Cultured
D000199:Actins; D002352:Carrier Proteins; D002712:Chlorides; D028021:Sodium-Potassium-Chloride Symporters; D002034:Bumetanide; D003571:Cytochalasin B; D012964:Sodium; D011188:Potassium