title: CD8+ cutaneous anaplastic large-cell lymphoma: report of two cases with immunophenotyping, T-cell-receptor gene rearrangement and electron microscopic studies.
abstract: Two cases are reported of cutaneous anaplastic large-cell lymphoma with the suppressor/cytotoxic (CD8) phenotype. In both cases there was a solitary skin tumour in which there was a dense infiltrate with large irregularly shaped cells which on immunophenotyping expressed CD8. DNA hybridization analysis showed rearrangements of the T-cell-receptor gene in both cases.
authors.affiliation: Department of Dermatology, Saiseikai Yokomashi Nanbu Hospital, Kanagawa, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kikuchi
authors.forename: K
authors.initials: K
authors.lastname: Sakuraoka
authors.forename: S
authors.initials: S
authors.lastname: Kurihara
authors.forename: M
authors.initials: M
authors.lastname: Akiyama
authors.forename: H
authors.initials: H
authors.lastname: Shimizu
authors.forename: T
authors.initials: T
authors.lastname: Nishikawa
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D018949:Antigens, CD1; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D017252:CD3 Complex; D016827:CD8 Antigens / Q000032:analysis*; D005260:Female; D015329:Gene Rearrangement, T-Lymphocyte / Q000235:genetics; D006801:Humans; D016130:Immunophenotyping / Q000379:methods; D007633:Keratins / Q000032:analysis; D017730:Ki-1 Antigen; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D015336:Molecular Probe Techniques; D011948:Receptors, Antigen, T-Cell / Q000032:analysis / Q000235:genetics; D012878:Skin Neoplasms / Q000235:genetics / Q000276:immunology* / Q000473:pathology
chemical_list: D015703:Antigens, CD; D018949:Antigens, CD1; D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm; D017252:CD3 Complex; D016827:CD8 Antigens; D017730:Ki-1 Antigen; D011948:Receptors, Antigen, T-Cell; D007633:Keratins