Eel calcitonin induces creatine kinase BB activity in the rat kidney medulla.
We have studied the effect of intravenous injection of eel calcitonin (ECT) on creatine kinase E.C.2.7.3.2. BB isozyme (CKBB) in the kidney of male Wistar rats. CKBB immunoreactivity was detected by the peroxidase-antiperoxidase method. Eel calcitonin increased CKBB immunoreactivity in the renal medulla in a dose-dependent fashion. Its effect peaked at 2 h and lasted up to 24 h. The distribution of activated CKBB in the kidney occurs in the same areas where highly specific CT-binding sites have been previously demonstrated, and is in agreement with the current concepts on renal actions of this hormone.
Bernardini
R
R
Institute of Pharmacology, University of Catania, Italy.
Fiore
C E
CE
Insirello
L
L
Pistritto
M
M
Costa
V
V
Clementi
G
G
D000818:Animals; D002116:Calcitonin / Q000494:pharmacology*; D003402:Creatine Kinase / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D004524:Eels / Q000378:metabolism*; D004790:Enzyme Induction / Q000187:drug effects; D007124:Immunoenzyme Techniques; D007527:Isoenzymes; D007679:Kidney Medulla / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D007527:Isoenzymes; D002116:Calcitonin; D003402:Creatine Kinase