The possible role of gliotoxin in health and disease.
Demonstration of the unique therapeutic properties of penicillin initiated an extensive investigation of other mould metabolites in the hope of finding other useful chemotherapeutic agents. While many hundreds of active substances were studied very few indeed satisfied the criteria necessary for clinical use. Among those whose toxicity ruled them out was gliotoxin. Recently, however a chance observation, in quite a different context, suggests that gliotoxin may prove valuable in human tissue transplantation.
Waring
P
P
John Curtin School of Medical Research, Australian National University, Canberra.
Mullbacher
A
A
D000818:Animals; D005912:Gliotoxin / Q000494:pharmacology*; D006801:Humans; D016377:Organ Transplantation
D005912:Gliotoxin