Quinolinehydrazones as inhibitors of retroviral reverse transcriptase.
The inhibitory activity of a series of 2- and 4-quinolinehydrazones on retroviral reverse transcriptase has been studied on enzymes from M-MuLV, RAV-2, and on a crude lysate of HIV-1, assuming the first two enzymes as potential models of the third. The highest activity is mainly found in lipophilic, water soluble 4-quinolinehydrazones. The inhibitory activity of these compounds decreases in changing from the M-MuLV to the RAV-2, and HIV-1 enzymes, in this order.
Bartolucci
C
C
Instituto di Strutturistica Chimica G. Giacomello, C.N.R., Roma.
Cellai
L
L
Di Filippo
P
P
Brizzi
V
V
Pellerano
C
C
Savini
L
L
Benedetto
A
A
Elia
G
G
D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D012190:Retroviridae / Q000201:enzymology*; D018894:Reverse Transcriptase Inhibitors
D006835:Hydrazones; D011804:Quinolines; D018894:Reverse Transcriptase Inhibitors