Clonal 6p21 rearrangement is restricted to the mesenchymal component of an endometrial polyp.
Previous cytogenetic analyses revealed t(6;20)(p21;q13) in two endometrial polyps. We karyotyped a large endometrial polyp in which 19 of 25 metaphase cells contained a t(1;6;4)(q21;p21;q13). Subsequent combined immunohistochemical/cytogenetic analysis showed all aberrant metaphase cells to be of mesenchymal derivation, whereas epithelial cells from the polyp were diploid. These studies indicate that rearrangement of chromosome band 6p21 is a characteristic cytogenetic aberration in the stromal component of endometrial polyps.
Fletcher
J A
JA
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115.
Pinkus
J L
JL
Lage
J M
JM
Morton
C C
CC
Pinkus
G S
GS
D000368:Aged; D000369:Aged, 80 and over; D002871:Chromosome Banding; D002878:Chromosomes, Human, Pair 1; D002894:Chromosomes, Human, Pair 4; D002896:Chromosomes, Human, Pair 6; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D007621:Karyotyping; D008648:Mesoderm / Q000473:pathology; D011127:Polyps / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics