title: [Bone marrow involvement in Whipple's disease].
abstract: The authors present the case of a 57 years old woman who had atypical Whipple's disease characterized solely by migratory arthralgia, weight loss and unexplained anemia which had lasted for 5 years. Once the diagnosis of Whipple's disease was established on abdominal lymph node biopsy, the retrospective study of a bone marrow biopsy revealed the presence of PAS-positive sickle-formed particles within medullary macrophages. Review of the literature attests the rarity of ante-mortem diagnosis of Whipple's disease in bone marrow preparations. We suggest that bone marrow biopsies stained with the PAS technique be employed in clinical settings of chronic migratory arthralgia and unexplained anemia.
authors.affiliation: Département de Pathologie, Hôpital Cantonal Universitaire, Faculté de Médecine, Genève, Suisse.
authors.forename: S
authors.initials: S
authors.lastname: Remadi
authors.forename: M
authors.initials: M
authors.lastname: Starobinski
authors.forename: S
authors.initials: S
authors.lastname: Widgren
mesh_terms: D000740:Anemia / Q000209:etiology; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology*; D005260:Female; D006801:Humans; D007596:Joints; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D015431:Weight Loss; D008061:Whipple Disease / Q000150:complications / Q000473:pathology*