Soluble interleukin-2 receptors in children with juvenile chronic arthritis.
Concentrations of interleukin-2 receptors were studied in sera of 81 patients with pauciarticular-, polyarticular-, and systemic-onset juvenile chronic arthritis using a double antibody "sandwich" enzyme-linked immunosorbent technique. Serum concentrations were significantly increased in all subgroups when compared with the healthy controls. Higher concentrations were found in systemic onset disease than in pauci- or polyarticular onset disease. Serum levels were found to be increased in both inactive and active disease, showing maximal values in patients with systemic features. A correlation to C-reactive protein, alpha 1-acid glycoprotein, and erythrocyte sedimentation was observed. Increased sIL-2R values suggest disease activity despite the absence of clinical symptoms.
Fassbender
K
K
Department of Rheumatology, University Hospital, Felix-Platter-Spital, Basel, Switzerland.
Michels
H
H
Vogt
P
P
Aeschlimann
A
A
Müller
W
W
D000209:Acute-Phase Proteins / Q000032:analysis; D000293:Adolescent; D000328:Adult; D001171:Arthritis, Juvenile / Q000097:blood* / Q000473:pathology; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009961:Orosomucoid / Q000032:analysis; D015375:Receptors, Interleukin-2 / Q000032:analysis*
D000209:Acute-Phase Proteins; D009961:Orosomucoid; D015375:Receptors, Interleukin-2; D002097:C-Reactive Protein