title: Pregnancy modulates the expression of beta-N-acetylhexosaminidase in rat serum and tissues.
abstract: 1. beta-N-Acetylhexosaminidases in maternal rat serum were separated by DEAE-cellulose chromatography and compared with those of adult rat serum. 2. In pregnant serum there is an increase of the isoenzymes which are entirely composed of beta-subunits (B and intermediate forms). 3. These alterations could be compared to those already described in human pregnancy. 4. The levels of beta-N-acetylhexosaminidase and the relative expression of alpha- and beta-subunits in normal and pregnant serum correlate with the above isoenzyme expression. 5. The increase of B and intermediate forms as well as the increase of specific activity during pregnancy was not peculiar to maternal serum but was also demonstrated in several foetal tissues and in maternal tissues, in which cases the beta-N-acetylhexosaminidase isoenzyme patterns closely resemble the foetal ones rather than those of the adult rat tissues. 6. These analogies strongly suggest that the expression of beta-subunit of beta-N-acetylhexosaminidase is regulated by hormones or other factors related to pregnancy.
authors.affiliation: Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università di Perugia, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Emiliani
authors.forename: P
authors.initials: P
authors.lastname: Locci
authors.forename: L
authors.initials: L
authors.lastname: Marinucci
authors.forename: R
authors.initials: R
authors.lastname: Rossi
authors.forename: A
authors.initials: A
authors.lastname: Orlacchio
mesh_terms: D000818:Animals; D002848:Chromatography, DEAE-Cellulose; D005260:Female; D007668:Kidney / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000097:blood / Q000378:metabolism*; D051381:Rats; D013154:Spleen / Q000378:metabolism; D001619:beta-N-Acetylhexosaminidases / Q000097:blood / Q000378:metabolism*
chemical_list: D001619:beta-N-Acetylhexosaminidases