MK-801 prevents brain lesions and delayed-nonmatching-to-sample deficits produced by pyrithiamine-induced encephalopathy in rats.
Rats were trained on a spatial delayed-nonmatching-to-sample (DNMTS) task and assigned by block randomization to one of four treatments: pyrithiamine-induced thiamine deficiency (PTD), PTD with administration of MK-801 after 12 days, control with MK-801 treatment, and control without MK-801. After 15 days of treatment followed by 21 days of recovery, the PTD rats showed significant deficits for DNMTS accuracy at retention intervals (RI) that ranged from 3.0 s to 15.0 s, the RIs that produced 75% accuracy on DNMTS in staircase training, and the rate at which a novel radial arm maze task was learned. The PTD-treated rats had consistent lesions in the thalamus and the mammillary bodies. MK-801 protected rats from both behavioral deficits and brain lesions (assessed quantitatively and qualitatively) that were produced by the PTD treatment.
Robinson
J K
JK
University of New Hampshire, Durham 03824.
Mair
R G
RG
D000425:Alcohol Amnestic Disorder / Q000503:physiopathology*; D000818:Animals; D001070:Appetitive Behavior / Q000187:drug effects / Q000502:physiology; D001931:Brain Mapping; D004193:Discrimination Learning / Q000187:drug effects* / Q000502:physiology; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D008297:Male; D011939:Mental Recall / Q000187:drug effects* / Q000502:physiology; D009949:Orientation / Q000187:drug effects* / Q000502:physiology; D011745:Pyrithiamine / Q000037:antagonists & inhibitors / Q000633:toxicity*; D051381:Rats; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects* / Q000502:physiology; D012153:Retention, Psychology / Q000187:drug effects / Q000502:physiology; D013788:Thalamus / Q000187:drug effects / Q000503:physiopathology; D013832:Thiamine Deficiency / Q000139:chemically induced* / Q000503:physiopathology; D014899:Wernicke Encephalopathy / Q000139:chemically induced* / Q000503:physiopathology
D016194:Receptors, N-Methyl-D-Aspartate; D011745:Pyrithiamine; D016291:Dizocilpine Maleate