title: Effects of insulin-like growth factors and growth hormone on the in vitro proliferation of T lymphocytes.
abstract: The insulin-like growth factors I and II (IGF-I and IGF-II) promote proliferation and differentiation of many cell types. We report that recombinant IGF-I and IGF-II augment both the lectin- and anti-CD3-induced proliferation of human peripheral blood mononuclear cells (PBMC) at concentrations proportional to their binding affinities. IGF-I and IGF-II also augmented the lectin-induced proliferation of purified T lymphocytes. Effects of IGF-I were found in cultures of T cells vigorously depleted for monocytes and supplemented with saturating concentrations of interleukin-1. The latter results indicate that the effect of IGF-I on the proliferation of T lymphocytes can occur independent of monocytes or monocyte-derived factors.
authors.affiliation: Department of Immunology, University Hospital for Children, Utrecht, The Netherlands.
authors.forename: R
authors.initials: R
authors.lastname: Kooijman
authors.forename: M
authors.initials: M
authors.lastname: Willems
authors.forename: G T
authors.initials: GT
authors.lastname: Rijkers
authors.forename: A
authors.initials: A
authors.lastname: Brinkman
authors.forename: S C
authors.initials: SC
authors.lastname: van Buul-Offers
authors.forename: C J
authors.initials: CJ
authors.lastname: Heijnen
authors.forename: B J
authors.initials: BJ
authors.lastname: Zegers
mesh_terms: D002352:Carrier Proteins / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D013006:Growth Hormone / Q000494:pharmacology*; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D007335:Insulin-Like Growth Factor II / Q000494:pharmacology*; D009000:Monocytes / Q000166:cytology; D011994:Recombinant Proteins; D013002:Somatomedins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000166:cytology*
chemical_list: D002352:Carrier Proteins; D018969:Insulin-Like Growth Factor Binding Proteins; D011994:Recombinant Proteins; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II; D013006:Growth Hormone