Effect of long-term use of Norplant implants on haemostatic function.
This study describes the effects of Norplant on haemostatic function after 5 years of use in 97 women. There was a decrease in vitamin-K dependent Factors II, V, VII and reduction in fibrinolytic activity at 2 and 4 years of use. Increased platelet numbers and accelerated platelet aggregation were found throughout the 5 years of Norplant use, whilst raised alpha 2-Macroglobulin (a2-M) and antithrombin III (ATIII) antigen level were observed for up to 4 years of use. Prolonged Norplant use does not appear to activate the coagulation system and does not enhance a state of hypercoagulation.
Singh
K
K
Department of Obstetrics and Gynaecology, National University of Singapore, National University Hospital, Singapore.
Viegas
O A
OA
Koh
S C
SC
Ratnam
S S
SS
D000941:Antigens / Q000032:analysis; D000990:Antithrombin III / Q000032:analysis / Q000276:immunology; D001779:Blood Coagulation Factors / Q000032:analysis; D004343:Drug Implants; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D016912:Levonorgestrel / Q000494:pharmacology*; D008137:Longitudinal Studies; D010314:Partial Thromboplastin Time; D010958:Plasminogen / Q000032:analysis; D010960:Plasminogen Activators / Q000032:analysis; D015539:Platelet Activation / Q000187:drug effects; D010976:Platelet Count / Q000187:drug effects; D011446:Prospective Studies; D011517:Prothrombin Time; D000511:alpha-Macroglobulins / Q000032:analysis
D000941:Antigens; D001779:Blood Coagulation Factors; D004343:Drug Implants; D006454:Hemoglobins; D000511:alpha-Macroglobulins; D016912:Levonorgestrel; D000990:Antithrombin III; D010958:Plasminogen; D010960:Plasminogen Activators