title: Preferential loss of striato-external pallidal projection neurons in presymptomatic Huntington's disease.
abstract: We have reported previously that striatal projection neurons are differentially affected in the course of Huntington's disease, and in a prior patient report we noted that differential loss of striatal projection neurons occurs also in patients with presymptomatic Huntington's disease. Striatal neurons projecting to the external segment of the globus pallidus or the substantia nigra show evident loss, whereas those projecting to the internal segment of the globus pallidus appear relatively spared at presymptomatic and early stages of symptomatic Huntington's disease. We now report similar findings in a second apparently presymptomatic Huntington's disease allele carrier.
authors.affiliation: Department of Neurology, University of Michigan, Ann Arbor.
authors.forename: R L
authors.initials: RL
authors.lastname: Albin
authors.forename: A
authors.initials: A
authors.lastname: Reiner
authors.forename: K D
authors.initials: KD
authors.lastname: Anderson
authors.forename: L S
authors.initials: LS
authors.lastname: Dure
authors.forename: B
authors.initials: B
authors.lastname: Handelin
authors.forename: R
authors.initials: R
authors.lastname: Balfour
authors.forename: W O
authors.initials: WO
authors.lastname: Whetsell
authors.forename: J B
authors.initials: JB
authors.lastname: Penney
authors.forename: A B
authors.initials: AB
authors.lastname: Young
mesh_terms: D000328:Adult; D002470:Cell Survival; D003342:Corpus Striatum / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D004745:Enkephalins / Q000378:metabolism; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D005917:Globus Pallidus / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D006816:Huntington Disease / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000502:physiology*; D013373:Substance P / Q000378:metabolism; D009435:Synaptic Transmission
chemical_list: D004745:Enkephalins; D005904:Glial Fibrillary Acidic Protein; D013373:Substance P