title: An immunohistochemical and ultrastructural study of case of small-cell neuroendocrine carcinoma in the ampullary region of the duodenum.
abstract: One case of small-cell neuroendocrine carcinoma in the ampullary region of the duodenum is reported. The histological appearance of the tumor was identical to pulmonary small-cell carcinoma. Neuroendocrine differentiation was demonstrated immunohistochemically by positive immunoreaction for neuron specific enolase, Leu-7 and chromogranin, and ultrastructurally by the presence of scanty dense-core neurosecretory type granules. Small-cell neuroendocrine carcinoma in the ampulla of Vater is extremely rare. To our knowledge, this is the sixth reported case.
authors.affiliation: Second Department of Pathology, Okayama University Medical School, Japan.
authors.forename: A B
authors.initials: AB
authors.lastname: Sarker
authors.forename: Y
authors.initials: Y
authors.lastname: Hoshida
authors.forename: S
authors.initials: S
authors.lastname: Akagi
authors.forename: K
authors.initials: K
authors.lastname: Hayashi
authors.forename: I
authors.initials: I
authors.lastname: Murakami
authors.forename: H J
authors.initials: HJ
authors.lastname: Jeon
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Akagi
mesh_terms: D014670:Ampulla of Vater; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002272:Carcinoembryonic Antigen / Q000032:analysis; D018288:Carcinoma, Small Cell / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D004379:Duodenal Neoplasms / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007372:Interferons / Q000008:administration & dosage; D008875:Middle Aged; D016577:Pancreaticoduodenectomy; D005641:Tegafur / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D002272:Carcinoembryonic Antigen; D014409:Tumor Necrosis Factor-alpha; D000509:alpha-Fetoproteins; D005641:Tegafur; D007372:Interferons