title: [Hemostatic disorders following polytrauma--the role of physiologic coagulation inhibitors during the preclinical phase].
abstract: Coagulation changes due to polytrauma are considered to be an important determinant for the outcome. In this context, physiological inhibitors of activated coagulation are highlighted with special reference to antithrombin-III (AT-III). Blood samples of 20 randomly selected adults with polytrauma (Injury Severity Score mean = 36.7 +/- 8.6) were investigated. To investigate the very early onset of coagulation changes, samples were taken as early as possible at the site of emergency (mean = 18.3 +/- 5.5 min. after trauma) as well as at hospital admission (mean = 78.0 +/- 10.4 min.). By means of a specially designed "mini-lab", basic processing of the samples harvested (centrifugation, pipetting, freezing) was done on the spot to obtain haemostaseological results that agree as closely as possible with the subsequent analyses. Due to the activation of intravascular coagulation as well as the consumption of physiological inhibitors, comprehensive coagulation disturbances become obvious at the time of hospital admission. These are intensified by haemodilution as a consequence of high-dose fluid replacement. However, significantly elevated levels of specific coagulation reaction products (thrombin-antithrombin-III-complex) give evidence of the consumption of inhibitory potential exceeding haemodilution.
authors.affiliation: Abteilung für Anästhesiologie und Internsivmedizin, Bundeswehrkrankenhaus Ulm.
authors.forename: L
authors.initials: L
authors.lastname: Lampl
authors.forename: E
authors.initials: E
authors.lastname: Seifried
authors.forename: M
authors.initials: M
authors.lastname: Tisch
authors.forename: M
authors.initials: M
authors.lastname: Helm
authors.forename: B
authors.initials: B
authors.lastname: Maier
authors.forename: K H
authors.initials: KH
authors.lastname: Bock
mesh_terms: D000328:Adult; D000368:Aged; D000990:Antithrombin III / Q000502:physiology*; D001777:Blood Coagulation / Q000502:physiology*; D005260:Female; D006023:Glycoproteins / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009104:Multiple Trauma / Q000503:physiopathology*; D011486:Protein C / Q000502:physiology*; D017293:Protein S
chemical_list: D006023:Glycoproteins; D011486:Protein C; D017293:Protein S; D000990:Antithrombin III