[Research of the relation between the type of asthenia of the spleen and kidney and platelet associated antibodies and T-lymphocyte subsets in idiopathic thrombocytopenic purpura].
Idiopathic thrombocytopenic purpura (ITP) is a kind of disease associated with immunity. At present a great quantity of study on ITP has been made on humoral and cellular immunity. But there are few reports about the relationship between the types based on the differential diagnosis of TCM and immune rationale of ITP. In order to deeply explore the relationship between the types based on differential diagnosis of TCM and immune rationale of ITP., the authors measured PAIg and T lymphocyte subsets of 34 ITP patients of asthenia of both Spleen and Kidney. The value of PAIgG increased in both types of Spleen failing to control blood (SFCB) and deficiency of Spleen-yin and Kidney -yin (DSYKY), and the value of PAIgG of the type of DSYKY was significantly higher than that of SFCB (P less than 0.01). OKT3, OKT4/OKT8 of the type of SFCB remarkably decreased (P less than 0.05), OKT4, OKT4/OKT8 of DSYKY also remarkably decreased (P less than 0.001), while OKT8 significantly increased (P less than 0.001). The above results suggested that the type of DSYKY has more serious immune dysfunction than the type of SFCB, and the types of SFCB and DSYKY has close relationship with PAIg T lymphocyte subsets.
Zhan
W Y
WY
Handan TCM Hospital.
Huang
Z Q
ZQ
Xue
Z Z
ZZ
D000293:Adolescent; D000328:Adult; D016824:Antigens, Human Platelet / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis; D016516:CD4-CD8 Ratio; D002648:Child; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007674:Kidney Diseases / Q000276:immunology; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000145:classification / Q000276:immunology*; D013158:Splenic Diseases / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D016710:Yin Deficiency / Q000276:immunology*
D016824:Antigens, Human Platelet; D001323:Autoantibodies; D007074:Immunoglobulin G