title: [The effects of cholestyramine on pancreatic secretion].
abstract: The objective was to evaluate the effect of biliary salt depletion on morphology and function of the exocrine pancreas. Cholestyramine (15 g/day) was given during fifteen days to male Wistar rats in order to evaluate changes in pancreas weight as well as in enzymatic content of pancreatic tissue and duodenal juice (amylase, lipase and trypsinogen); in duodenal juice, bile salt concentration was also measured; Moreover ultrastructure of the exocrine pancreas was studied. Our results show an increase in pancreas weight in rats treated with cholestyramine, with a significant increase of amylase (p < 0.05) and trypsinogen in pancreatic tissue (p < 0.01), and of lipase in duodenal juice (p < 0.05). Ultrastructural changes were absent. It is concluded that cholestyramine, probably through a bile salt depletion, stimulates pancreatic function and growth, as well as lipase secretion.
authors.affiliation: Departamento de Medicina, Facultad de Medicina, Valladolid.
authors.forename: M E
authors.initials: ME
authors.lastname: Santamaría Gil
authors.forename: M C
authors.initials: MC
authors.lastname: Fernández Alonso
authors.forename: M S
authors.initials: MS
authors.lastname: de Andrés Loste
authors.forename: E
authors.initials: E
authors.lastname: González Fernández
authors.forename: F J
authors.initials: FJ
authors.lastname: Blanco Varela
authors.forename: M C
authors.initials: MC
authors.lastname: Coca García
authors.forename: A
authors.initials: A
authors.lastname: Caro-Patón Gómez
mesh_terms: D000681:Amylases / Q000032:analysis / Q000187:drug effects; D000818:Animals; D002792:Cholestyramine Resin / Q000494:pharmacology*; D004386:Duodenum; D007419:Intestinal Secretions / Q000187:drug effects / Q000201:enzymology; D008049:Lipase / Q000032:analysis / Q000187:drug effects; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism* / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D014362:Trypsinogen / Q000032:analysis / Q000187:drug effects
chemical_list: D002792:Cholestyramine Resin; D014362:Trypsinogen; D008049:Lipase; D000681:Amylases