title: Very high collagen increase in placentae of smoking mothers.
abstract: In 55 placentae, collected at term from clinically normal pregnancies, hydroxyproline was assayed. Thirty were from mothers who smoke and 25 from nonsmokers. In placentae of smokers, hydroxyproline concentration was 42.77 +/- 8.77 micrograms/mg of tissue and in these of nonsmokers 22.52 +/- 7.46 micrograms/mg. Such high a difference discloses a large increment in placental collagen production in smokers, which may account for some of the noxious effects of tobacco on pregnancy.
authors.affiliation: Department of Medicine, School of Medicine, University of São Paulo, Brazil.
authors.forename: D
authors.initials: D
authors.lastname: Andreucci
authors.forename: W R
authors.initials: WR
authors.lastname: Teodoro
authors.forename: C
authors.initials: C
authors.lastname: Mariani
mesh_terms: D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000737:chemistry*; D009538:Nicotine / Q000009:adverse effects; D010920:Placenta / Q000737:chemistry* / Q000187:drug effects; D011247:Pregnancy; D012907:Smoking / Q000009:adverse effects*
chemical_list: D009538:Nicotine; D006909:Hydroxyproline