[Decreased blood pressure in sleep and left ventricular hypertrophy in patients with kidney transplants].
Since left-ventricular hypertrophy (LVH) has been identified as a poor prognostic indicator in patients with secondary hypertension, we investigated 38 renal transplant recipients on antihypertensive medication with 24-h ambulatory blood-pressure measurement (SpaceLabs 90207) and determined their left-ventricular mass by two-dimensional guided M-mode echocardiography. An increased left-ventricular mass correlated with a reduced fall of diastolic blood pressure during sleep (r = 0.29; p less than 0.05), as well as with a reduced fall of mean arterial pressure during sleep (r = 0.31; p less than 0.05). Therefore, a less pronounced afterload during sleep is related to more severe left-ventricular hypertrophy, suggesting a worse cardiovascular prognosis.
Gatzka
C D
CD
4. Medizinische Klinik, Universität Erlangen-Nürnberg.
Schobel
H P
HP
Vogt-Ladner
G
G
Neumayer
H H
HH
Schmieder
R E
RE
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D015924:Blood Pressure Monitors; D002306:Cardiac Volume / Q000502:physiology; D006332:Cardiomegaly / Q000503:physiopathology*; D002940:Circadian Rhythm / Q000502:physiology*; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006977:Hypertension, Renal / Q000503:physiopathology* / Q000601:surgery; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000503:physiopathology*; D012894:Sleep Stages / Q000502:physiology*; D016277:Ventricular Function, Left / Q000502:physiology*