title: Cyclin B is associated with centrosomes in Drosophila mitotic cells.
abstract: We have studied by way of confocal laser scanning microscopy the subcellular localization of cyclin B in Drosophila-cultured cells and report here evidence that a part of the cyclin B cell pool is closely associated with the centrosome. This cyclin B centrosomal signal is strong in prophase and metaphase but disappears during anaphase. Moreover, the signal is absent in the acentriolar Drosophila cell line 1182-4. These results put forward additional arguments suggesting that the centrosome plays an important role in the control of the cell cycle.
authors.affiliation: Unité Associée du CNRS 1135, Université Pierre et Marie Curie, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Debec
authors.forename: C
authors.initials: C
authors.lastname: Montmory
mesh_terms: D000818:Animals; D015153:Blotting, Western; D002460:Cell Line; D002502:Centrioles / Q000378:metabolism*; D016213:Cyclins / Q000378:metabolism*; D004331:Drosophila melanogaster; D005455:Fluorescent Antibody Technique; D008938:Mitosis
chemical_list: D016213:Cyclins