Transient hypothyroxinaemia associated with developmental delay in very preterm infants.
In 563 surviving very preterm (less than 32 weeks gestational age) and/or very low birthweight (less than 1500 g) infants the relationship between neonatal thyroxine concentration and psychomotor development at 2 years of age (corrected for preterm birth) was studied. A significant association was found between low neonatal thyroxine concentration and a negative score on the three milestones of development. These findings do not support the view that transient hypothyroxinaemia in preterm infants is harmless.
Meijer
W J
WJ
TNO Institute of Preventive Health Care, Leiden, The Netherlands.
Verloove-Vanhorick
S P
SP
Brand
R
R
van den Brande
J L
JL
D002675:Child, Preschool; D003409:Congenital Hypothyroidism; D002658:Developmental Disabilities / Q000097:blood* / Q000453:epidemiology; D005500:Follow-Up Studies; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000453:epidemiology; D007223:Infant; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D016015:Logistic Models; D016017:Odds Ratio; D011597:Psychomotor Performance; D013974:Thyroxine / Q000097:blood*
D013974:Thyroxine