Neuroendocrine and epithelial markers in diagnostic bronchial lung cancer biopsy specimens.
The incidence of neuroendocrine and epithelial markers was investigated by immunocytochemistry in archival, lung cancer, bronchial biopsy specimens (n = 48). No correlation of antigenicity with histological type was observed. 79% non-small cell lung carcinoma (NSCLC) and 61% small cell lung carcinoma (SCLC) were positive for epithelial markers. HuTu-m3 did not discriminate adenocarcinomas and squamous cell carcinomas from SCLC. 83% SCLC and 93% NSCLC were positive for one or more neuroendocrine marker. Multiple neuroendocrine markers were found in 61% SCLC, 83% NSCLC and 83% squamous cell carcinomas, this incidence being greater in the NSCLC group, and in the squamous carcinomas in particular, than previously reported.
Burnett
H E
HE
Clatterbridge Cancer Research Trust, Clatterbridge Hospital, Bebington, Wirral, U.K.
Zakhour
H D
HD
Walker
C
C
D000906:Antibodies; D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis*; D001706:Biopsy; D001984:Bronchial Neoplasms / Q000737:chemistry* / Q000276:immunology / Q000473:pathology; D002289:Carcinoma, Non-Small-Cell Lung / Q000737:chemistry* / Q000276:immunology / Q000473:pathology; D018288:Carcinoma, Small Cell / Q000737:chemistry* / Q000276:immunology / Q000473:pathology; D004702:Endocrine Glands / Q000737:chemistry / Q000276:immunology; D004848:Epithelium / Q000737:chemistry; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry* / Q000276:immunology / Q000473:pathology; D008562:Membrane Glycoproteins / Q000032:analysis; D018396:Mucin-1; D009420:Nervous System / Q000737:chemistry / Q000276:immunology; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D013194:Staining and Labeling
D000906:Antibodies; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D008562:Membrane Glycoproteins; D018396:Mucin-1; D010751:Phosphopyruvate Hydratase