In vitro effects of Etodolac and acetylsalicylic acid on human chondrocyte metabolism.
The effects of two nonsteroidal anti-inflammatory drugs (NSAIDs), Etodolac (ETO) and acetylsalicylic acid (ASA), used at pharmacological concentrations, were tested on several metabolic parameters of human chondrocytes cultivated in three-dimensional culture. The results indicated that proteoglycan synthesis was significantly decreased by ASA treatment, whereas Etodolac did not affect this parameter. Neither ASA nor Etodolac modified type-II collagen production. Both NSAIDs were potent inhibitors of PGE2 production, but Etodolac was more efficient at equimolar concentrations. In contrast, collagenolytic activity was unaffected by Etodolac.
Henrotin
Y
Y
Laboratory of Radioimmunoassay, University of Liège, C.H.U., Belgium.
Bassleer
C
C
Franchimont
P
P
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology*; D002358:Cartilage, Articular / Q000166:cytology / Q000378:metabolism*; D003094:Collagen / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D015232:Dinoprostone / Q000378:metabolism; D017308:Etodolac; D006801:Humans; D007210:Indoleacetic Acids / Q000494:pharmacology*; D011509:Proteoglycans / Q000378:metabolism; D011863:Radioimmunoassay
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007210:Indoleacetic Acids; D011509:Proteoglycans; D017308:Etodolac; D003094:Collagen; D004247:DNA; D015232:Dinoprostone; D001241:Aspirin