title: Benzimidazole condensed ring systems. 8 (1). Synthesis of some substituted 1-oxo-1H,5H-pyrido[1,2-a] benzimidazole-4-carbonitriles with anticipated antimicrobial activity.
abstract: As a part of research project on the syntheses of a number of pyrido[1,2-a]benzimidazole derivatives with possible antimicrobial activity, some 3-(chloro or morpholino)-acetyloxy (2,3), 3-(N,N-dimethylcarbamoyloxy) (4,5) and 3-tosyloxy-1-oxo-1H,5H-pyrido[1,2a]benzimidazole-4-carbonitrile s (6) were prepared and evaluated for such activity. Many compounds exhibited in vitro antimicrobial activity and structure-activity relationship is discussed.
authors.affiliation: Pharmaceutical Chemistry Department-Faculty of Pharmacy, Alexandria University, Egypt.
authors.forename: E A
authors.initials: EA
authors.lastname: Badawey
authors.forename: Y M
authors.initials: YM
authors.lastname: Gohar
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011728:Pyridones / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D001562:Benzimidazoles; D011728:Pyridones