title: [Estimating cancer latency using data from a case-control study with time-related factors. I. A general multivariate theory and algorithm].
abstract: In the present paper, a general multivariate approach, estimating cancer latency using data from a case-control study with time-related factors, is proposed based on the theory for risk analysis of states. Making use of a forward-analysis and backward-synthesis strategy and excess exposure fraction, this approach can simultaneously accomplish multivariate logistic regression analysis and estimation of susceptible exposure ages and latency distribution. The latency is resolved into a accumulative period and preneoplastic period. It gives a theoretical interpretation for primary and secondary prevention of cancer.
authors.affiliation: Cancer Institute, Chinese Academy of Medical Sciences, Beijing.
authors.forename: Y Y
authors.initials: YY
authors.lastname: Liu
mesh_terms: D000465:Algorithms; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D004198:Disease Susceptibility; D004781:Environmental Exposure; D006801:Humans; D015999:Multivariate Analysis; D009369:Neoplasms / Q000453:epidemiology* / Q000517:prevention & control; D012307:Risk Factors; D013997:Time Factors