title: [The GPI-anchored Fc gamma receptor III in the activation of granulocytes].
abstract: PMN express primary two Fc gamma receptors for IgG immune complexes. Fc gamma RII is a transmembraneous molecule in contrast to Fc gamma RIII on PMN which is GPI-linked. In spite of the different membrane linkage both Fc gamma R use calcium as an intracellular signal. Cross-linking of Fc gamma RIII is more effective for induction of H2O2 production than Fc gamma RII. Monoclonal IgG1x cryoglobulin complexes activate PMN via Fc gamma RIII as shown by calcium mobilization and H2O2 production.
authors.affiliation: Abteilung Immunologie und Transfusionsmedizin, Medizinische Hochschule Hannover.
authors.forename: M
authors.initials: M
authors.lastname: Hundt
authors.forename: R E
authors.initials: RE
authors.lastname: Schmidt
mesh_terms: D000943:Antigens, Differentiation / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D006017:Glycolipids; D017261:Glycosylphosphatidylinositols; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D066298:In Vitro Techniques; D009504:Neutrophils / Q000502:physiology*; D010716:Phosphatidylinositols; D011961:Receptors, Fc / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D017452:Receptors, IgG; D015398:Signal Transduction
chemical_list: D000943:Antigens, Differentiation; D006017:Glycolipids; D017261:Glycosylphosphatidylinositols; D010716:Phosphatidylinositols; D011961:Receptors, Fc; D017452:Receptors, IgG; D006861:Hydrogen Peroxide; D002118:Calcium