title: Effects of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) on somatic mutation in a soybean test system.
abstract: The mutagenic activity of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) was assayed in heterozygous soybean plants (Y11y11), based on the appearance of mutational spots (yellow, dark green and twin) on the leaves. When soybean seeds were treated with IQ at concentrations of 0.01-0.1 microgram/ml, the frequency of mutational spots per leaf increased significantly in proportion to the concentration of IQ. At higher concentrations IQ was toxic. The mutagenicity of IQ was enhanced by pretreatment with the hepatic S9 fraction from Aroclor-induced rats. The numbers of yellow and dark green spots per leaf increased markedly by the treatment with IQ and S9-activated IQ, but the number of twin spots did not increase.
authors.affiliation: Life Science Division, Hokkaido Institute of Public Health, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Katoh
authors.forename: M
authors.initials: M
authors.lastname: Maekawa
authors.forename: Y
authors.initials: Y
authors.lastname: Sano
mesh_terms: D001140:Aroclors / Q000633:toxicity; D016009:Chi-Square Distribution; D004789:Enzyme Activation; D005506:Food Contamination; D017343:Genes, Plant / Q000187:drug effects; D008110:Liver Extracts; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens; D011804:Quinolines / Q000633:toxicity*; D013025:Glycine max / Q000187:drug effects* / Q000235:genetics*
chemical_list: D001140:Aroclors; D008110:Liver Extracts; D009153:Mutagens; D011804:Quinolines; C029216:2-amino-3-methylimidazo(4,5-f)quinoline