[Experimental study on dose effect relationships between ultraviolet rays and its early impairment].
An experimental study on dose time effect relationships was carried out on mice by using epidermic cell DNA damage, skin immune suppression and histological change as indicators. The results showed that when animal exposed to a daily dose of 0.12 MED of Ultraviolet rays for 12 weeks, no obvious change was found. It suggested that this dose level would be safe. But at 0.5 MED dose level, increase in UDS repair, decrease in number of skin Langerhans cells and the presence of skin-aging occurred, showing that 0.5 MED dosage had a slow damaging effect. With regard to the effect of time, the longer the exposure the stronger the effects, but the early impairment was mainly related to the daily dose, rather than to the total dose.
Tai
S P
SP
China Medical University, Shenyang.
D000818:Animals; D004249:DNA Damage / Q000528:radiation effects*; D004285:Dogs; D004307:Dose-Response Relationship, Radiation; D007801:Langerhans Cells / Q000528:radiation effects; D051379:Mice; D011833:Radiation Injuries, Experimental; D012867:Skin / Q000528:radiation effects; D016176:T-Lymphocyte Subsets / Q000528:radiation effects; D013997:Time Factors; D014466:Ultraviolet Rays