A new angiogenesis inhibitor, FR-111142.
FR-111142 is a new angiogenesis inhibitor produced by a fungus Scolecobasidium arenarium F-2015. FR-111142 inhibited endothelial cell proliferation in vitro and angiogenesis in the growing chick chorioallantoic membrane model in vivo. Further, FR-111142 also suppressed the solid tumor growth in mice.
Otsuka
T
T
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
Shibata
T
T
Tsurumi
Y
Y
Takase
S
S
Okuhara
M
M
Terano
H
H
Kohsaka
M
M
Imanaka
H
H
D000482:Allantois; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002642:Chick Embryo; D002823:Chorion; D004730:Endothelium, Vascular / Q000187:drug effects; D004852:Epoxy Compounds / Q000302:isolation & purification* / Q000494:pharmacology; D005260:Female; D005285:Fermentation; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D003904:Mitosporic Fungi / Q000145:classification / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D013141:Spiro Compounds / Q000302:isolation & purification* / Q000494:pharmacology
D004852:Epoxy Compounds; D013141:Spiro Compounds; C074363:FR 111142