The genotoxicity of organotin compounds in SOS chromotest and rec-assay.
In these days pollution by organotin compounds in the environment extends widely and effects on human health are feared. We studied the genotoxicity of various organotin compounds (butyltins, phenyltins, methyltins) and inorganic tin (SnCl4), which are present in the environment, with the SOS chromotest and the rec-assay. Mono-n-butyltin oxide, n-butyltin trichloride and di-n-butyltin dichloride showed high SOS-inducing potency in the SOS chromotest with Escherichia coli PQ37. Di-n-butyltin dichloride, tri-n-butyltin chloride, bis(tri-n-butyltin)oxide, dimethyltin dichloride and trimethyltin chloride were recognized as genotoxic chemicals by the rec-assay.
Hamasaki
T
T
Department of Public Health, Gifu Pharmaceutical University, Japan.
Sato
T
T
Nagase
H
H
Kito
H
H
D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology / Q000235:genetics; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D009947:Organotin Compounds / Q000494:pharmacology*; D013014:SOS Response, Genetics / Q000187:drug effects*; D014001:Tin / Q000494:pharmacology*; D001616:beta-Galactosidase / Q000378:metabolism
D009153:Mutagens; D009947:Organotin Compounds; D015112:4-Nitroquinoline-1-oxide; D014001:Tin; D001616:beta-Galactosidase