title: Concomitant release of renin, angiotensin I, and angiotensin II during superfusion of human juxtaglomerular cell tumor.
abstract: Increasing evidence indicates that angiotensin II can be formed by juxtaglomerular cells (JGC) and cosecreted with renin. We investigated the existence of this local renin-angiotensin system in a human JGC tumor, using an in vitro superfusion. The JGC tumor was found concomitantly to release renin and angiotensin I and II. Sequential addition of atrial natriuretic peptide, dopamine, and a somatostatin analog in the superfusion did not affect renin or angiotensin I and II release. The data provide evidence that the human JGC tumor in vitro generates angiotensin II, and supports its possible role as a local in vivo regulator of kidney function.
authors.affiliation: Institute of Semeiotica Medica, University of Padova, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Fallo
authors.forename: D
authors.initials: D
authors.lastname: D'Agostino
authors.forename: D
authors.initials: D
authors.lastname: Armanini
authors.forename: L
authors.initials: L
authors.lastname: Caregaro
authors.forename: F
authors.initials: F
authors.lastname: Mantero
mesh_terms: D000328:Adult; D000803:Angiotensin I / Q000378:metabolism*; D000804:Angiotensin II / Q000378:metabolism*; D009320:Atrial Natriuretic Factor / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D005260:Female; D006801:Humans; D007606:Juxtaglomerular Apparatus; D007680:Kidney Neoplasms / Q000378:metabolism* / Q000648:ultrastructure; D008854:Microscopy, Electron; D015282:Octreotide / Q000494:pharmacology; D010477:Perfusion; D012083:Renin / Q000378:metabolism*
chemical_list: D000804:Angiotensin II; D009320:Atrial Natriuretic Factor; D000803:Angiotensin I; D012083:Renin; D015282:Octreotide; D004298:Dopamine