title: [Treatment of soil-transmitted helminth infections by anthelmintics in current use].
abstract: The efficacy of broad-spectrum anthelmintics in current use was studied in Hengshan County, Hunan Province. The vermicides under study include albendazole (400mg, single dose), mebendazole composite (mebendazole 100 mg and levamisole 25mg bid x 3d), oxantel pyrantel pamoate composite (pyrantel pamoate 150 mg and oxantel pamoate 150 mg bid x 2d), and pyrantel pamoate composite (base 10 mg/kg, single dose). Therapeutic effect assessed 2 weeks after medication revealed Ascaris egg negative rates or cure rates (CR) of 97.5-100% for the former 3 regimens, and 80.9% for the latter one; while CR for hookworm infection were 95.4%, 78.6-100%, 96.7% and 83.3%, respectively. A follow-up survey pursued 4 weeks post treatment showed no significant difference in CR for the above regimens. Judging from CR in Trichuris trichiura infection, pyrantel pamoate composite was recommended as the drug of choice (89.3%), which was followed by mebendazole composite (64.6-83.8%) and albendazole (28.2-42.6%), whereas pyrantel pamoate was inefficacious. Obvious egg reduction rates were evidenced post application of the above drugs in trichuriasis treatment except pyrantel pamoate at single dose.
authors.affiliation: Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shanghai.
authors.forename: L Q
authors.initials: LQ
authors.lastname: Zu
authors.forename: Z X
authors.initials: ZX
authors.lastname: Jiang
authors.forename: S H
authors.initials: SH
authors.lastname: Yu
authors.forename: X M
authors.initials: XM
authors.lastname: Ding
authors.forename: X H
authors.initials: XH
authors.lastname: Bin
authors.forename: H F
authors.initials: HF
authors.lastname: Yang
authors.forename: H Q
authors.initials: HQ
authors.lastname: Zhu
authors.forename: C S
authors.initials: CS
authors.lastname: Kuang
authors.forename: Q W
authors.initials: QW
authors.lastname: Chen
authors.forename: C H
authors.initials: CH
authors.lastname: Zhou
mesh_terms: D015766:Albendazole / Q000627:therapeutic use; D000871:Anthelmintics / Q000627:therapeutic use*; D001196:Ascariasis / Q000188:drug therapy; D004338:Drug Combinations; D006725:Hookworm Infections / Q000188:drug therapy; D006801:Humans; D008463:Mebendazole / Q000627:therapeutic use; D009349:Nematode Infections / Q000188:drug therapy*; D011716:Pyrantel Pamoate / Q000627:therapeutic use; D014257:Trichuriasis / Q000188:drug therapy
chemical_list: D000871:Anthelmintics; D004338:Drug Combinations; D011716:Pyrantel Pamoate; D008463:Mebendazole; D015766:Albendazole