[Biochemical bases of ftorafur-potentiating effects of perfluorodecalin, inducer of cytochrome P-450 dependent microsomal monooxygenases].
Activity of cytochrome P-450-dependent monooxygenase system is significantly lower in hepatoma H-2-73 and Lewis lung carcinoma-bearing mice as compared to that in control animals. An inhibition of the cytochrome P-450 system was observed after the injection of ftorafur. Treatment of the mice with perfluorodecalin markedly increased the antineoplastic activity of ftorafur determined by a loss of the leucocytes and of the weight hepatoma H-2-73- and Lewis lung carcinoma resistant to ftorafur alone.
Khlopushina
T G
TG
Krinskaia
A V
AV
Bukhman
V M
VM
Zherdev
V P
VP
Val'dman
A V
AV
D000818:Animals; D001802:Blood Substitutes; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004790:Enzyme Induction; D005466:Fluorocarbons / Q000627:therapeutic use*; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000201:enzymology; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008861:Microsomes / Q000201:enzymology*; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000201:enzymology; D010088:Oxidoreductases / Q000096:biosynthesis*; D010952:Plasma Substitutes; D005641:Tegafur / Q000627:therapeutic use*
D001802:Blood Substitutes; D005466:Fluorocarbons; D010952:Plasma Substitutes; D005641:Tegafur; C008805:perfluorodecalin; D003577:Cytochrome P-450 Enzyme System; D010088:Oxidoreductases