Peripheral blood cell activities of monoamine oxidase B and superoxide dismutase in Parkinson's disease.
Monoamine oxidase type B (MAO-B) and superoxide dismutase (SOD) are two enzyme systems that are potentially relevant to an oxidative stress model of Parkinson's disease (PD) causation. Activities of MAO-B in platelets (nmol/10(8) cells/hr) and total SOD in lymphocytes (U/mg protein) were assayed among 28 cases of idiopathic PD and 22 controls. As anticipated, MAO-B was lowest in PD cases on selegiline (L-deprenyl) therapy (mean 1.10). There was a slight deficit of MAO-B among male cases not taking selegiline compared to controls (3.78 vs. 4.15), but the opposite trend was observed for females (6.18 vs. 4.16). SOD was slightly higher in cases (7.40), than controls (6.81). Excess SOD among PD cases was seen irrespective of gender, age, or selegiline treatment, although none of the differences was statistically significant. Future research on SOD should take advantage of the availability of assays specific for the cytosolic and mitochondrial forms of the enzyme.
Checkoway
H
H
Department of Environmental Health, School of Public Health and Community Medicine, University of Washington, Seattle.
Costa
L G
LG
Woods
J S
JS
Castoldi
A F
AF
Lund
B O
BO
Swanson
P D
PD
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001792:Blood Platelets / Q000201:enzymology; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood*; D010300:Parkinson Disease / Q000097:blood* / Q000188:drug therapy / Q000201:enzymology; D012642:Selegiline / Q000627:therapeutic use; D013482:Superoxide Dismutase / Q000097:blood*
D012642:Selegiline; D013482:Superoxide Dismutase; D008995:Monoamine Oxidase