Influence of chemotherapy on hormone receptor concentration in a xenotransplanted endometrial cancer.
There is growing evidence that chemotherapy may influence the hormone receptor capacity in human carcinomas. The consideration of this assumption may be of importance for the therapeutic management of tumors with metastatic spread which underwent previous adjuvant chemotherapy. Therefore we investigated the influence of six different kinds of chemotherapy on the hormone receptor concentration and the percentage of receptor positive cells in xenotransplanted endometrial cancer. Our results can be summarized as follows: (1) We find neither a significant decrease in hormone receptor capacity after chemotherapeutic treatment (biochemical determination), nor do we see a decrease in the percentage of ER/PR pos. cells (immunohistochemistry). (2) On the other hand, there is no increase in hormone receptor concentration inducible by chemotherapy and no increase in ER/PR pos. cells immunohistochemically.
Vering
A
A
Department of Gynecology and Oncology, Main University, Medical Center, Frankfurt, FRG.
Michel
R T
RT
Mitze
M
M
Stegmüller
M
M
Bender
H G
HG
D000230:Adenocarcinoma / Q000378:metabolism*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001761:Bleomycin / Q000494:pharmacology; D016190:Carboplatin / Q000494:pharmacology; D003520:Cyclophosphamide / Q000494:pharmacology; D016889:Endometrial Neoplasms / Q000378:metabolism*; D015251:Epirubicin / Q000494:pharmacology; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D008937:Mitomycins / Q000494:pharmacology; D009368:Neoplasm Transplantation; D011959:Receptors, Estradiol / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D014183:Transplantation, Heterologous
D000970:Antineoplastic Agents; D008937:Mitomycins; D011959:Receptors, Estradiol; D011980:Receptors, Progesterone; D001761:Bleomycin; D015251:Epirubicin; D003520:Cyclophosphamide; D016190:Carboplatin; D005472:Fluorouracil