[Rat liver antioxidant defense mechanism to the action of aromatic amines].
The effects of diaminobiphenyl, biphenylamine and tetraaminobiphenyl on lipid peroxidation and antioxidant protective mechanisms in the subcellular fractions of rat liver have been studied. It was found that activation of lipid peroxidation plays a crucial role in the manifestation of hepatotoxic activities of diaminobiphenyl and biphenylamine, this effect being due to the decrease of the protective activity of the antioxidant system during intoxication by these compounds. Tetraaminobiphenyl does not influence the rate of lipid peroxidation. It is concluded that structural differences determine the differences in the mechanisms of adaptation of the antioxidant system to the effect of aromatic amines.
Lomonosova
E E
EE
Pikulev
A T
AT
Kurchenko
V P
VP
D000611:Aminobiphenyl Compounds / Q000378:metabolism / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D005609:Free Radicals; D015227:Lipid Peroxidation; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D051381:Rats
D000611:Aminobiphenyl Compounds; D000975:Antioxidants; D005609:Free Radicals