Nucleotide receptors on DDT1 MF-2 vas deferens cells.
On exposure to triphosphatic nucleotides vas deferens DDT1 MF-2 smooth muscle cells responded with an outward K+ current as measured with the whole-cell patch clamp configuration. The rank order of potency was: ATP greater than UTP greater than TTP greater than CTP = GTP. The responses evoked by these agonists were blocked by suramin. Adenosine, ADP, alpha, beta-methylene-ATP and 2-methylthio-ATP did not affect the transmembrane current. The responses evoked by the nucleotides in DDT1 MF-2 cells are supposed to be mediated via 'nucleotide' receptors.
Van der Zee
L
L
Department of Pharmacology/Clinical Pharmacology, University of Groningen, Netherlands.
Nelemans
A
A
Den Hertog
A
A
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D002478:Cells, Cultured; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009130:Muscle, Smooth / Q000378:metabolism*; D009711:Nucleotides / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D014649:Vas Deferens / Q000378:metabolism
D007473:Ion Channels; D009711:Nucleotides; D011956:Receptors, Cell Surface; D000255:Adenosine Triphosphate