Hyaluronan and cell locomotion.
Hyaluronan (HA), a glycosaminoglycan, has long been implicated in cell locomotion. We have shown that HA production regulates the locomotion of H-ras-transformed cells. This autocrine motility mechanism is mediated by a novel HA receptor termed RHAMM, an acronym for Receptor for HA Mediated Motility. HA:RHAMM interactions regulate directional locomotion of tumor cells and result in enhanced protein tyrosine phosphorylation that may be a critical messenger mechanism for initiation of locomotion.
Turley
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EA
Manitoba Institute of Cell Biology, Winnipeg, Canada.
D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D011905:Genes, ras / Q000502:physiology; D006801:Humans; D018960:Hyaluronan Receptors; D006820:Hyaluronic Acid / Q000502:physiology*; D009369:Neoplasms / Q000503:physiopathology; D051381:Rats; D011956:Receptors, Cell Surface / Q000502:physiology; D014945:Wound Healing / Q000502:physiology
D018960:Hyaluronan Receptors; D011956:Receptors, Cell Surface; D006820:Hyaluronic Acid