title: Lung mechanics (FRC and static pressure-volume diagram) after endotracheal surfactant instillation: preliminary observations.
abstract: Preliminary measurements of functional residual capacity (FRC) with the sulphurhexafluoride technique and static pressure volume diagrams were performed in newborn infants with respiratory distress syndrome receiving endotracheal instillation of natural porcine surfactant (Curosurf, 100 or 200 mg/kg). Within the first hour after surfactant treatment there was an increase in FRC and distensibility of the lungs persisting for 24-48 h.
authors.affiliation: Department of Paediatrics, University Hospital, Lund, Sweden.
authors.forename: N W
authors.initials: NW
authors.lastname: Svenningsen
authors.forename: L
authors.initials: L
authors.lastname: Björklund
authors.forename: C
authors.initials: C
authors.lastname: Vilstrup
authors.forename: O
authors.initials: O
authors.lastname: Werner
mesh_terms: D001688:Biological Products; D005652:Functional Residual Capacity / Q000187:drug effects; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007322:Instillation, Drug; D010743:Phospholipids; D011663:Pulmonary Surfactants / Q000494:pharmacology*; D012121:Respiration, Artificial; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy; D015656:Respiratory Mechanics / Q000187:drug effects*
chemical_list: D001688:Biological Products; D010743:Phospholipids; D011663:Pulmonary Surfactants; C068291:poractant alfa