Variability of crossreactivity of IgE antibodies to group I and V allergens in eight grass pollen species.
Crossreactivity to Dactylis glomerata, Festuca rubra, Phleum pratense, Anthoxanthum odoratum, Secale cereale, Zea mays, and Phragmites communis of IgE antibodies against Lol p I or Lol p V was investigated by means of RAST-inhibition. Within a group of sera the degree of crossreactivity was demonstrated to be highly variable. Individual sera were not always equally crossreactive to all pollen species. A high degree of crossreactivity for Group I allergens did not necessarily implicate the same for Group V. Group I and Group V representatives were found to be present in all eight species. It was demonstrated that within this group of grass species significant quantitative and qualitative differences exist, with respect to Group I and Group V allergens. Species with a low phylogenetic affinity to Lolium perenne, like Zea mays and Phragmites communis showed a very low degree of reactivity, even when measured with the most crossreactive sera. A higher taxonomic relationship however, did not always implicate a closer antigenic resemblance. Antigenically both allergens from Zea mays are more similar to Lol p I and Lol p V, than the analogues in Secale cereale.
Van Ree
R
R
Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, Amsterdam.
Driessen
M N
MN
Van Leeuwen
W A
WA
Stapel
S O
SO
Aalberse
R C
RC
D000485:Allergens / Q000276:immunology*; D000940:Antigenic Variation / Q000276:immunology; D003429:Cross Reactions / Q000276:immunology*; D000939:Epitopes / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D006109:Poaceae; D011058:Pollen / Q000276:immunology*; D011852:Radioallergosorbent Test
D000485:Allergens; D000939:Epitopes; D007073:Immunoglobulin E