title: Plasmodium falciparum induced perturbations of the erythrocyte antioxidant system.
abstract: Erythrocyte antioxidants catalase, superoxide dismutase, reduced glutathione and glutathione peroxidase were studied in cells harbouring different growth stages of Plasmodium falciparum. Catalase and superoxide dismutase showed significant decrease during parasite maturation indicating hampered metabolism of hydrogen peroxide and superoxide anions. Glutathione peroxidase also exhibited a downward trend during the growth of P. falciparum, while there was a moderate accumulation of reduced glutathione. These findings suggest decreased utilization of the reduction potential in detoxification of reactive oxygen species. The fall in all three antioxidant enzymes studied was highly significant (P less than 0.001) in erythrocytes with mature stages of the parasite (trophozoites, schizonts). The increased vulnerability of erythrocytes to damage, which parallels the growth phases of the parasite emphasizes the need for early treatment of P. falciparum malaria to minimise red cell destruction and the resulting anaemia.
authors.affiliation: Department of Parasitology, Post-graduate Institute of Medical Education & Research Chandigarh, India.
authors.forename: K
authors.initials: K
authors.lastname: Mohan
authors.forename: M L
authors.initials: ML
authors.lastname: Dubey
authors.forename: N K
authors.initials: NK
authors.lastname: Ganguly
authors.forename: R C
authors.initials: RC
authors.lastname: Mahajan
mesh_terms: D000818:Animals; D000975:Antioxidants; D002374:Catalase / Q000097:blood; D004912:Erythrocytes / Q000469:parasitology / Q000502:physiology*; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D016778:Malaria, Falciparum / Q000097:blood* / Q000469:parasitology; D009249:NADP / Q000097:blood; D010084:Oxidation-Reduction; D010963:Plasmodium falciparum; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000975:Antioxidants; D009249:NADP; D006861:Hydrogen Peroxide; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione