title: The varieties of ribonuclease P.
abstract: Ribonuclease P is a ribozyme involved in tRNA processing that is present in all cells and organelles that synthesize tRNA. Most of our understanding of ribonuclease P derives from studies of the bacterial enzyme. This enzyme has been characterized biochemically and a secondary structure for the RNA subunit has been proposed. Isolation and characterization of ribonuclease P from diverse Archaea and Eukarya are now modifying and adding to our model of this unusual enzyme. The latter instances of RNase P differ from the bacterial version, but similarities are emerging.
authors.affiliation: Department of Biochemistry, University of Nebraska-Lincoln 68583-0718.
authors.forename: S C
authors.initials: SC
authors.lastname: Darr
authors.forename: J W
authors.initials: JW
authors.lastname: Brown
authors.forename: N R
authors.initials: NR
authors.lastname: Pace
mesh_terms: D000818:Animals; D001419:Bacteria / Q000201:enzymology; D001483:Base Sequence; D004722:Endoribonucleases / Q000737:chemistry* / Q000235:genetics; D005057:Eukaryotic Cells / Q000201:enzymology; D006801:Humans; D008969:Molecular Sequence Data; D015388:Organelles / Q000201:enzymology; D012329:RNA, Bacterial / Q000737:chemistry; D016337:RNA, Catalytic / Q000737:chemistry* / Q000235:genetics; D012343:RNA, Transfer / Q000737:chemistry; D043262:Ribonuclease P; D012441:Saccharomyces cerevisiae / Q000201:enzymology
chemical_list: D012329:RNA, Bacterial; D016337:RNA, Catalytic; D012343:RNA, Transfer; D004722:Endoribonucleases; C058330:mitochondrial RNA-processing endoribonuclease; C468368:RPP14 protein, human; D043262:Ribonuclease P