title: Behaviour of several 'progression markers' during the HIV-Ab seroconversion period. Comparison with later stages.
abstract: Two acute phase reactants, four cytokines, five soluble factors and lymphocyte subpopulations have been simultaneously evaluated in 16 subjects before and closely after the HIV-Ab seroconversion time. The same variables have also been determined in 50 HIV-Ab-negative high risk subjects, in 36 CDC II-III and in 30 CDC IV patients, utilizing a mixed longitudinal epidemiological model. The results show significant variations of few parameters in the early phases (increase: sCD8, beta-2-Microglobulin, sIL-2R, sCD23, Neopterin, IFN-alpha; decrease: CD4+ lymphocytes). In the course of the disease, many others parameters progressively increase (IFN-tau, IL-4, IL-6, acid-alpha 1-glycoprotein, alpha 1-antitrypsin) or decrease (B- and T-lymphocytes). Ferritin, in particular, highly increases only in CDC IV stage. These data may be useful to monitor patients during the entire course of their disease and to suggest the time elapsed from seroconversion.
authors.affiliation: Laboratory of Clinical Pathology, San Gallicano Institute, Roma, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Cordiali Fei
authors.forename: A
authors.initials: A
authors.lastname: Massa
authors.forename: G
authors.initials: G
authors.lastname: Prignano
authors.forename: M
authors.initials: M
authors.lastname: Pietravalle
authors.forename: L
authors.initials: L
authors.lastname: Alemanno
authors.forename: G
authors.initials: G
authors.lastname: Vitelli
authors.forename: G
authors.initials: G
authors.lastname: Palamara
authors.forename: A
authors.initials: A
authors.lastname: Giglio
authors.forename: G M
authors.initials: GM
authors.lastname: Gandolfo
authors.forename: G
authors.initials: G
authors.lastname: Gentili
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood*; D001708:Biopterins / Q000031:analogs & derivatives / Q000097:blood; D016207:Cytokines / Q000097:blood; D006679:HIV Seropositivity / Q000097:blood* / Q000276:immunology; D006801:Humans; D016131:Lymphocyte Subsets / Q000276:immunology; D008297:Male; D019798:Neopterin; D013997:Time Factors
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; D016207:Cytokines; D001708:Biopterins; D019798:Neopterin