Glisoprenins, new inhibitors of acyl-CoA: cholesterol acyltransferase produced by Gliocladium sp. FO-1513. I. Production, isolation and physico-chemical and biological properties.
Gliocladium sp. FO-1513 was found to produce novel inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT). Two active compounds, designated glisoprenins A and B, were isolated from the culture broth of the producing strain by a conventional method. The IC50 values of glisoprenins A and B for ACAT activity were 46 and 61 microM in an enzyme assay using rat liver microsomes, and 1.2 and 0.57 microM in a J774 macrophage assay, respectively.
Tomoda
H
H
Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
Huang
X H
XH
Nishida
H
H
Masuma
R
R
Kim
Y K
YK
Omura
S
S
D000818:Animals; D005233:Fatty Alcohols; D005285:Fermentation; D051379:Mice; D003904:Mitosporic Fungi / Q000145:classification / Q000378:metabolism*; D051381:Rats; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors* / Q000302:isolation & purification / Q000494:pharmacology
D005233:Fatty Alcohols; C077321:glisoprenin A; C077322:glisoprenin B; D002785:Sterol O-Acyltransferase