title: Magnetic resonance image synthesis from analytic solutions of spin-echo and radio frequency-spoiled gradient-echo images.
abstract: OBJECTIVE
  To synthesize magnetic resonance images (MRI) in real-time using a minimal data set obtained with routine clinical protocols and stored in a picture archiving and communication system (PACS) database.
  
  
  METHODS
  Analytic solutions for T1 and T2 were obtained from a double and a single spin-echo set, with routine parameters. Analytic solutions from radio frequency-spoiled gradient-echo images, with TRs as low as 33 mseconds, also were used to synthesize gradient-echo images.
  
  
  RESULTS
  Phantom studies showed that the errors in the synthesized images were significantly smaller than the errors in the T1- and T2-calculated images and similar to the source images. The gradient-echo images resulted in significant scan time savings.
  
  
  CONCLUSIONS
  MRI synthesis from analytic solutions of T1, T2, and rho saves computational time and yields accurate values for the intrinsic parameters while allowing the use of routine clinical protocols. The availability of clinical images in the PACS database and the ability to synthesize images in real-time has allowed the development of a practical interactive teaching module.
authors.affiliation: Department of Radiological Sciences, School of Medicine, University of California, Los Angeles.
authors.forename: S
authors.initials: S
authors.lastname: Sinha
authors.forename: U
authors.initials: U
authors.lastname: Sinha
authors.forename: H
authors.initials: H
authors.lastname: Kangarloo
authors.forename: H K
authors.initials: HK
authors.lastname: Huang
mesh_terms: D001921:Brain / Q000033:anatomy & histology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008961:Models, Structural