title: Neurokinin A-like immunoreactivity in articular afferents of the cat.
abstract: Dorsal root ganglion cells with axons innervating the cat's knee joint via the medial articular nerve were retrogradely labelled with Fast blue. Neurokinin A-like immunoreactivity was found in 4.5 +/- 1.1% (mean +/- S.D. of 5 nerves and 695 cells) of the articular afferents. Colchicine treatment of the ganglia increased the percentage of immunopositive cells to 8.5 +/- 0.7% (mean +/- S.D. of 6 nerves and 554 cells) after 3-22 h. The diameter distribution of the immunopositive somata ranged from 20 to 50 microns with a maximum at 26-30 microns. Comparing the proportions of neurokinin A-immunopositive cells with those of substance P, it can be calculated on the basis of mRNA encoding that neurokinin A is synthetized in about half of the substance P-containing primary articular afferents.
authors.affiliation: Physiologisches Institut, Universität Würzburg, FRG.
authors.forename: U
authors.initials: U
authors.lastname: Hanesch
authors.forename: B
authors.initials: B
authors.lastname: Heppelmann
authors.forename: R F
authors.initials: RF
authors.lastname: Schmidt
mesh_terms: D000344:Afferent Pathways / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D000578:Amidines; D000818:Animals; D001370:Axonal Transport; D002415:Cats; D003078:Colchicine / Q000494:pharmacology; D005456:Fluorescent Dyes; D005727:Ganglia, Spinal / Q000166:cytology / Q000502:physiology*; D007596:Joints / Q000166:cytology / Q000294:innervation*; D015288:Neurokinin A / Q000032:analysis* / Q000187:drug effects; D010525:Peripheral Nerves / Q000166:cytology / Q000502:physiology*
chemical_list: D000578:Amidines; D005456:Fluorescent Dyes; C031455:diamidino compound 253-50; D015288:Neurokinin A; D003078:Colchicine