Effects of butylated hydroxyanisole on ornithine decarboxylase activity induced by ultraviolet-B and PUVA in mouse skin.
The effects of butylated hydroxyanisole (BHA), a representative phenolic antioxidant, on the activity of ornithine decarboxylase (ODC, an indicator of tumor promotion and epidermal hyperproliferation) induced by ultraviolet-B (UVB) or PUVA in mouse skin were investigated. By topical application of BHA (55 mumol), PUVA-induced ODC activity was suppressed by about 60% at both 12 h and 24 h after treatment. In contrast, BHA failed to suppress UVB-induced ODC activity in mouse skin. These results suggest that the induction of ODC activity by UVB or PUVA is mediated by different pathways.
Kono
T
T
Department of Dermatology, Osaka City University Medical School, Japan.
Taniguchi
S
S
Mizuno
N
N
Fukuda
M
M
Maekawa
N
N
Hisa
T
T
Ishii
M
M
Otani
S
S
Hamada
T
T
D000818:Animals; D002083:Butylated Hydroxyanisole / Q000494:pharmacology*; D005260:Female; D051379:Mice; D008812:Mice, Hairless; D009955:Ornithine Decarboxylase / Q000378:metabolism* / Q000528:radiation effects; D011701:PUVA Therapy; D012867:Skin / Q000201:enzymology* / Q000528:radiation effects*; D014466:Ultraviolet Rays
D002083:Butylated Hydroxyanisole; D009955:Ornithine Decarboxylase