title: Production of anti-peptide specific antibody in mice following immunization with peptides conjugated to mannan.
abstract: In order to investigate the usefulness of polysaccharides as carriers for the induction of antibody to synthetic peptides, peptides representing residues 139-147 of the surface antigen of hepatitis B and residues 129-140 of the pre-S2 region of the protein were coupled to mannan and dextran via an aminocaproic spacer molecule. Of the two conjugates studied, only mannan was useful as a carrier for the efficient production of anti-peptide antibodies.
authors.affiliation: Department of Clinical Sciences, London School of Hygiene and Tropical Medicine, UK.
authors.forename: Y
authors.initials: Y
authors.lastname: Okawa
authors.forename: C R
authors.initials: CR
authors.lastname: Howard
authors.forename: M W
authors.initials: MW
authors.lastname: Steward
mesh_terms: D000614:Aminocaproates; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000096:biosynthesis*; D000918:Antibody Specificity; D003911:Dextrans / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D004797:Enzyme-Linked Immunosorbent Assay; D006514:Hepatitis B Surface Antigens; D000922:Immunotoxins / Q000276:immunology*; D008297:Male; D008351:Mannans / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C
chemical_list: D000614:Aminocaproates; D000888:Antibodies, Anti-Idiotypic; D003911:Dextrans; D006514:Hepatitis B Surface Antigens; D000922:Immunotoxins; D008351:Mannans