title: Scintigraphic demonstration of lactulose-induced accelerated proximal colon transit.
abstract: Although lactulose, a widely used cathartic, is known to increase stool frequency, details of its site of action in the colon are obscure. In the present study a noninvasive scintigraphic technique was used to closely follow the movements of proximal colonic contents. Lactulose, 10-20 mL three times daily, significantly accelerated mean transit through the ascending colon from 12.9 +/- 3.7 to 7.0 +/- 2.5 hours (n = 11; P less than 0.01). This was associated with the occurrence of mass movements, with six such events seen during lactulose treatment whereas only one was seen during the control study (P less than 0.05). Lactulose also accelerated movement through the rest of the colon so that at 24 hours after dosing the geometric center of the isotope bolus was distal to that seen during the control study (6.6 +/- 1.2 vs. 4.7 +/- 1.3; n = 11, P less than 0.001). This model of diarrhea in otherwise normal subjects was subsequently used to study the effects of viscous gels in diarrhea. The viscous and relatively poorly fermented gel ispaghula, 3.5 g three times daily, abolished mass movements and was associated with a small but significant increase in proximal colonic transit time, which increased from 6.1 +/- 2.1 to 7.7 +/- 1.5 hours (n = 8; P less than 0.05). By contrast, the viscous but readily fermentable gelling agent guar gum, 5 g three times daily, further accelerated the cathartic effect of lactulose, with the mean transit time decreasing from 6.4 +/- 2.3 to 4.7 +/- 1.7 hours (n = 8; P less than 0.05). The acceleration of proximal colonic transit by lactulose may be a useful model to study diarrhea and its modification by therapy.
authors.affiliation: Department of Physiology and Pharmacology, University of Nottingham, England.
authors.forename: L
authors.initials: L
authors.lastname: Barrow
authors.forename: K P
authors.initials: KP
authors.lastname: Steed
authors.forename: R C
authors.initials: RC
authors.lastname: Spiller
authors.forename: P J
authors.initials: PJ
authors.lastname: Watts
authors.forename: C D
authors.initials: CD
authors.lastname: Melia
authors.forename: M C
authors.initials: MC
authors.lastname: Davies
authors.forename: C G
authors.initials: CG
authors.lastname: Wilson
mesh_terms: D000293:Adolescent; D000328:Adult; D003106:Colon / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D005782:Gels; D006801:Humans; D007205:Indium Radioisotopes; D007792:Lactulose / Q000494:pharmacology*; D008297:Male; D011877:Radionuclide Imaging
chemical_list: D005782:Gels; D007205:Indium Radioisotopes; D007792:Lactulose