title: Selected ion monitoring for the determination of bromovalerylurea in human plasma.
abstract: A gas chromatography-selected ion monitoring procedure with chemical ionization is described for the determination of bromovalerylurea (BVU) in human plasma. BVU was extracted with ether after addition of 2-bromo-2-methylpropylurea as an internal standard. The lower limit of BVU quantification by this method was 2 ng/0.1 ml plasma volume. This procedure was used to determine the sequential plasma levels of BVU in a human volunteer following a single oral dose of a commercial analgesic.
authors.affiliation: Research Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Kokatsu
authors.forename: R
authors.initials: R
authors.lastname: Yomoda
authors.forename: T
authors.initials: T
authors.lastname: Suwa
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001968:Bromisovalum / Q000008:administration & dosage / Q000097:blood*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male
chemical_list: D001968:Bromisovalum