title: Cytogenetic and FISH studies of abnormal X chromosomes in a patient with ANLL.
abstract: We report a case of idic(X)(q13),r(X)(p22q13), and del(X)(:p11-->cen-->q11:) in a 71-year-old female patient with de novo acute nonlymphocytic leukemia (ANLL), FAB-M4. The abnormal X chromosomes of this patient were identified cytogenetically by G-banding technique and were further confirmed by fluorescence in situ hybridization (FISH) using an alpha-satellite probe to chromosome X centromere. The features of this are compared with other cases reported in the literature.
authors.affiliation: Cancer Center of SBRI and Genetrix, Inc., Scottsdale, AZ 85251.
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
authors.forename: C S
authors.initials: CS
authors.lastname: Berger
authors.forename: R
authors.initials: R
authors.lastname: Morgan
authors.forename: D
authors.initials: D
authors.lastname: Roth
authors.forename: J F
authors.initials: JF
authors.lastname: Stone
authors.forename: A A
authors.initials: AA
authors.lastname: Sandberg
mesh_terms: D000368:Aged; D002869:Chromosome Aberrations; D002999:Clone Cells; D005260:Female; D005453:Fluorescence; D006801:Humans; D017403:In Situ Hybridization / Q000379:methods; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D012303:Ring Chromosomes; D014960:X Chromosome