Intellectual development at age 12 years of children with congenital hypothyroidism diagnosed by neonatal screening.
Twenty-seven patients with congenital hypothyroidism diagnosed by neonatal screening were examined at the age of 12 years. The 12 patients with severe hypothyroidism at diagnosis (thyroxine < 2 micrograms/dl (< 26 nmol/L), and area-of-the-knee epiphyses < 0.05 cm2 had a lower IQ than the 15 patients with less severe hypothyroidism (mean +/- SD, 89 +/- 17 vs 104 +/- 10; p < 0.007). Comparisons of patients and siblings confirm that this difference was due to the severity of hypothyroidism.
Glorieux
J
J
Department of Pediatrics, Université de Montréal, Quebec, Canada.
Dussault
J
J
Van Vliet
G
G
D002648:Child; D003409:Congenital Hypothyroidism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis; D007231:Infant, Newborn; D007360:Intelligence; D008297:Male; D015997:Neonatal Screening