Sister-chromatid exchange and chromosome aberrations induced by paracetamol in vivo in bone-marrow cells of mice.
Sister-chromatid exchange (SCE) and chromosome aberrations (CA) induced by paracetamol (PC), a common analgesic, were studied in vivo on bone-marrow cells of mice. The trend tests for the evidence of dose-response effects for both SCE and CA were significant. The significant increase in SCE as well as CA induced by PC may be attributed to the fact that PC can induce genotoxicity through DNA damage. Thus, the present study indicates that PC was genotoxic in vivo in bone-marrow cells of mice.
Giri
A K
AK
Division of Toxicology, Central Drug Research Institute, Chattar Manzil Palace, Lucknow, India.
Sivam
S S
SS
Khan
K A
KA
D000082:Acetaminophen / Q000633:toxicity*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D005260:Female; D008297:Male; D051379:Mice; D012854:Sister Chromatid Exchange
D000082:Acetaminophen