[Characterization of thyroglobulin in a patient with functioning and non-functioning benign thyroid tumors].
The chemical and immunological properties of thyroglobulin (Tg) in tissue obtained from a patient co-existed with two types of thyroid tumors, i.e., functioning and non-functioning, and were compared with the properties of Tg that was isolated from adjacent peripheral tissue. In the present observations, the Tg content was markedly increased in the non-functioning thyroid tumor. On the other hand, the Tg content in the functioning tumor was at the normal level. The iodine content of Tg was significantly lower in the non-functioning tumor than in peripheral tissues. Affinity with Lectins differed among Tg preparations, suggesting that the carbohydrate chain in the Tg was different in each nodule in a single individual.
Ishikita
T
T
Second Department of Surgery, Gunma University School of Medicine, Maebashi, Japan.
Iino
Y
Y
Ishida
T
T
Takei
H
H
Morishita
Y
Y
Tarutani
O
O
D000236:Adenoma / Q000145:classification / Q000378:metabolism* / Q000473:pathology; D004903:Erythrocyte Aggregation; D005260:Female; D006801:Humans; D007455:Iodine / Q000032:analysis; D037102:Lectins; D008875:Middle Aged; D013954:Thyroglobulin / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D013964:Thyroid Neoplasms / Q000145:classification / Q000378:metabolism* / Q000473:pathology
D037102:Lectins; D013954:Thyroglobulin; D007455:Iodine