[Studies of kinin-like properties of a new peptide isolated from bovine brain].
Kinin-like properties of two new peptides NRP-11 and P7 which have structural similarity with neurotensin (NT) and kallidin (K) were investigated. It was found that, unlike NT and K, the new peptides possess reduced myotropic and hypotensive activity. On the other hand, similarly to NT and K, the new peptides exhibited a high histamine-releasing activity in rat peritoneal mast cells. Possible central effects are implied for peptide NRP-11 isolated from bovine brain and its fragment P7.
Myshliakova
N V
NV
Ratkevich
M P
MP
Strazda
G M
GM
Klusha
V E
VE
Karelin
A A
AA
Karelina
E V
EV
D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D006168:Guinea Pigs; D006636:Histamine Release; D007609:Kallidin / Q000494:pharmacology; D007705:Kinins / Q000494:pharmacology; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism; D009479:Neuropeptides / Q000494:pharmacology; D009496:Neurotensin / Q000494:pharmacology; D051381:Rats
D007705:Kinins; D009479:Neuropeptides; D007609:Kallidin; D009496:Neurotensin