Pain on injection of propofol: comparison of lignocaine with metoclopramide.
We have conducted a randomized, double-blind study in 255 ASA I and II patients to compare the efficacy of lignocaine and metoclopramide in minimizing the pain of injection of i.v. propofol. When administered immediately before propofol into a dorsal hand vein, compared with placebo both drugs significantly reduced the incidence of pain on subsequent injection of propofol (P < 0.001). Twenty patients who had received metoclopramide (n = 85) experienced pain, compared with 18 who had received lignocaine (n = 85) and 42 who had been pretreated with saline (n = 85).
Ganta
R
R
Department of Anesthesiology, University of Oklahoma 73190.
Fee
J P
JP
D000293:Adolescent; D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007275:Injections, Intravenous / Q000009:adverse effects*; D008012:Lidocaine / Q000627:therapeutic use*; D008297:Male; D008787:Metoclopramide / Q000627:therapeutic use*; D008875:Middle Aged; D010146:Pain / Q000209:etiology / Q000517:prevention & control*; D011229:Preanesthetic Medication; D015742:Propofol / Q000008:administration & dosage*; D013924:Thrombophlebitis / Q000209:etiology
D008012:Lidocaine; D008787:Metoclopramide; D015742:Propofol