title: Shared antigenic epitopes of the major core proteins of human and simian immunodeficiency virus isolates.
abstract: Antigenic epitopes on the major core (gag) protein of isolates of simian and human immunodeficiency virus (SIV and HIV) were compared using a panel of eleven mouse monoclonal antibodies (Mabs) that recognized nine distinct gag epitopes. Viral isolates used for comparison were HIV-1IIIb, HIV-2ROD, and SIV isolates from macaque (SIVmac), sooty mangabey (SIVsm-UCD), African green monkey (SIVagm), and stump-tailed macaque (SIVstm-UCD). The relatedness of the various HIV and SIV isolates, as determined by Mabs to core protein epitopes, paralleled that ascertained by genetic sequencing.
authors.affiliation: Department of Medicine, School of Veterinary Medicine, University of California, Davis 95616.
authors.forename: J R
authors.initials: JR
authors.lastname: Higgins
authors.forename: S
authors.initials: S
authors.lastname: Sutjipto
authors.forename: P A
authors.initials: PA
authors.lastname: Marx
authors.forename: N C
authors.initials: NC
authors.lastname: Pedersen
mesh_terms: D000911:Antibodies, Monoclonal; D000939:Epitopes / Q000276:immunology*; D015683:Gene Products, gag / Q000276:immunology*; D006678:HIV / Q000276:immunology*; D016655:HIV Core Protein p24 / Q000276:immunology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D000939:Epitopes; C066594:Gag protein p27, Simian immunodeficiency virus; D015683:Gene Products, gag; D016655:HIV Core Protein p24