Methyl parathion-induced sperm shape abnormalities in mouse.
Metacid 50, the commercial grade of methyl parathion (O,O-dimethyl-O-4-nitrophenyl phosphorothionate), a commonly used organophosphorus insecticide, was tested for its genotoxicity in Swiss albino mice using the sperm abnormality assay. Sperms of albino mice were examined at two time intervals, 1 week and 5 weeks after a single acute oral treatment with the pesticide at four dose levels, viz., 75.0, 37.5, 18.75 and 9.375 mg/kg body weight corresponding to 1/2 LD50, 1/4 LD50, 1/8 LD50 and 1/16 LD50 values respectively. A dose-related statistically significant increase in the percentage of abnormal sperm observed indicates the genotoxic potency of methyl parathion.
Mathew
G
G
Department of Biosciences, Mangalore University, Mangalagangotri, India.
Vijayalaxmi
K K
KK
Abdul Rahiman
M
M
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008297:Male; D008743:Methyl Parathion / Q000633:toxicity*; D051379:Mice; D008815:Mice, Inbred Strains; D009153:Mutagens / Q000633:toxicity*; D012016:Reference Values; D013094:Spermatozoa / Q000002:abnormalities / Q000187:drug effects*
D009153:Mutagens; D008743:Methyl Parathion