title: Growth factor (M-CSF) and antigenic properties of macrophages in meningioma.
abstract: In meningiomas, transformed meningeal cells can share morphological aspects (in hemangiopericytic meningioma) and antigenic properties (i.e.: HLA-DR antigens expression) with elements of the monocyte/macrophage lineage. In this report, we describe a case of a highly vascular meningioma where numerous tumor cells, studied with immunohistochemical methods, present phenotypic properties of macrophages. Moreover, the cerebrospinal fluid (CF) analysis disclosed, using a biological assay, a high level of a growth factor for monocytic elements, the Macrophages Colony Stimulating Factor (M-CSF). Our findings may confirm that transitional aspects between different mesenchymal cells could be present in meningiomas.
authors.affiliation: II Neurological Clinic, University of Padova, School of Medicine, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Giometto
authors.forename: F
authors.initials: F
authors.lastname: Bozza
authors.forename: P
authors.initials: P
authors.lastname: Gallo
authors.forename: S
authors.initials: S
authors.lastname: Pagni
authors.forename: V
authors.initials: V
authors.lastname: Argentiero
authors.forename: S
authors.initials: S
authors.lastname: Ferla
authors.forename: S
authors.initials: S
authors.lastname: Mingrino
authors.forename: B
authors.initials: B
authors.lastname: Tavolato
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000134:cerebrospinal fluid; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D016173:Macrophage Colony-Stimulating Factor / Q000134:cerebrospinal fluid*; D008264:Macrophages / Q000276:immunology / Q000473:pathology*; D008562:Membrane Glycoproteins / Q000032:analysis; D008577:Meningeal Neoplasms / Q000134:cerebrospinal fluid / Q000276:immunology / Q000473:pathology*; D008875:Middle Aged; D018396:Mucin-1; D009113:Muramidase / Q000032:analysis; D014746:Vimentin / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000032:analysis
chemical_list: D015703:Antigens, CD; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D006680:HLA Antigens; D006684:HLA-DR Antigens; D008562:Membrane Glycoproteins; D018396:Mucin-1; D014746:Vimentin; D000515:alpha 1-Antitrypsin; D007633:Keratins; D016173:Macrophage Colony-Stimulating Factor; D009113:Muramidase