title: The clinical impact of thallium-201 reinjection scintigraphy for detection of myocardial viability.
abstract: In a clinical study, the value of thallium-201 reinjection was studied in 139 patients with suspected or known coronary artery disease who showed one or more persistent defects after conventional stress-redistribution imaging. Fifty-nine (42%) patients had sustained a Q-wave myocardial infarction. Sixty-eight (49%) patients showed a reversible defect in at least one myocardial segment at redistribution, while 71 (51%) had persistent defects only. Following reinjection additional segmental filling-in was seen in 95 (68%) patients, including 50 of the 68 (74%) patients with reversible defects and 45 of the 71 (63%) with persistent defects only. On the immediately post-exercise images, 458 (47%) of 973 segments showed perfusion defects. At redistribution 105 (23%) of the 458 defects showed filling-in, whereas of the remaining 353 persistent defects 164 (46%) resolved additionally after reinjection. Thirteen (10%) of 133 Q-wave related defects showed filling-in at redistribution compared with 22 (27%) of 82 remote defects (P = 0.001). After reinjection additional filling-in of defects was seen in 47 (39%) of 120 Q-wave related defects compared with 35 (58%) or 60 remote defects (P = 0.015). Overall, 60 (45%) of 133 Q-wave related defects resolved compared with 57 (70%) of 82 remote defects (P = 0.005).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Diagnostic Radiology (Division of Nuclear Medicine), University of Leiden, Netherlands.
authors.forename: A F
authors.initials: AF
authors.lastname: Kuijper
authors.forename: H W
authors.initials: HW
authors.lastname: Vliegen
authors.forename: E E
authors.initials: EE
authors.lastname: van der Wall
authors.forename: W P
authors.initials: WP
authors.lastname: Oosterhuis
authors.forename: A H
authors.initials: AH
authors.lastname: Zwinderman
authors.forename: B L
authors.initials: BL
authors.lastname: van Eck-Smit
authors.forename: M G
authors.initials: MG
authors.lastname: Niemeyer
authors.forename: E K
authors.initials: EK
authors.lastname: Pauwels
mesh_terms: D003327:Coronary Disease / Q000000981:diagnostic imaging*; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D013794:Thallium Radioisotopes; D013997:Time Factors
chemical_list: D013794:Thallium Radioisotopes