Effect of a single replacement of one of Ringer lactate, hypertonic saline/dextran, 7g% albumin, stroma-free hemoglobin, o-raffinose polyhemoglobin or whole blood on the long term survival of unanesthetized rats with lethal hemorrhagic shock after 67% acute blood loss.
This study is based on an unanesthetized lethal hemorrhagic shock rat model (67% blood volume bled in 2 stages). The 8 groups studied were as follows. 1. Control--no resuscitation fluid. 2. Reinfusion of rat's own shed whole blood. 3. Ringer lactate solution--3 times shed blood volume. The following 4 fluids were each given as equal to the shed blood volume. 4. 7.5g% NaCl hypertonic saline/6% Dextran 70, followed by 3 volumes Ringer lactate dextran. 5. Ringer lactate solution. 6. Human albumin 7g% in Ringer lactate. 7. Stroma-free hemoglobin in Ringer lactate 8. o-raffinose polyhemoglobin in Ringer Lactate. Blood pressure and other vital signs were recorded continuously during the control period, bleeding periods, infusion period and 60 minutes after infusion. After this all surviving animals were followed for 14 days with no other special treatments. Group 4 had transient (10 minutes) returned of blood pressure to control levels. The 3 groups with sustained blood pressure at control level when followed for 1 hour were groups 2, 6 and 7. The 2 groups with 100% survival on days 14 were group 2 and group 7.
Chang
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Artificial Cells & Organ Research Centre, Faculty of Medicine, McGill University, Montreal, P.Q., Canada.
Varma
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D000818:Animals; D001802:Blood Substitutes / Q000627:therapeutic use*; D001803:Blood Transfusion; D004195:Disease Models, Animal; D005069:Evaluation Studies as Topic; D006439:Hemodynamics; D006454:Hemoglobins / Q000627:therapeutic use; D007552:Isotonic Solutions; D010952:Plasma Substitutes / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012151:Resuscitation; D012771:Shock, Hemorrhagic / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D013997:Time Factors; D015430:Weight Gain
D001802:Blood Substitutes; D006454:Hemoglobins; D007552:Isotonic Solutions; D010952:Plasma Substitutes; C016484:hemoglobin, stroma free; C037158:polyhemoglobin