[The role of calmodulin and calcium ions in the immunosuppressive mechanism of the action of cyclosporin A].
The calcium pathway of Cyclosporine A (CyA) action on peripheral blood lymphocytes was assessed with regard to the literature data and self observations of kidney graft recipients. A significant relation between the immunosuppressive action of the drug and intracellular concentrations of Ca2+ is intimately linked with the regulatory potential of calmodulin. Because of the widespread clinical use of calcium channel blockers also considered influence of these drugs on immunosuppression by CyA and their importance in reducing its nephrotoxicity.
Adamiec
R
R
Katedra i Klinika Nefrologii AM, Wrocławiu.
D000596:Amino Acids; D002118:Calcium / Q000037:antagonists & inhibitors / Q000276:immunology*; D002147:Calmodulin / Q000037:antagonists & inhibitors / Q000276:immunology*; D016572:Cyclosporine / Q000494:pharmacology*; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects* / Q000276:immunology; D066298:In Vitro Techniques; D016030:Kidney Transplantation / Q000276:immunology*; D008954:Models, Biological; D008969:Molecular Sequence Data; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology*
D000596:Amino Acids; D002147:Calmodulin; D016572:Cyclosporine; D002118:Calcium