title: Aplasia of the retinal vessels combined with optic nerve hypoplasia, neonatal epileptic seizures, and lactic acidosis due to mitochondrial complex I deficiency.
abstract: A newborn male with mitochondrial complex I deficiency suffered from neonatal epileptic seizures, which later developed into infantile spasms. The infant was blind due to aplasia of the retinal vessels and hypoplasia of the optic nerve. There was congenital lactic acidosis, which persisted in later life. The boy was microcephalic and retarded. Muscular hypotonia later shifted to spasticity. Succinic acid was increased in urine. We assume that the aplasia of the retinal vessels is due to damage of the retinal ganglion cells caused by the mitochondrial disease in the first 3 to 4 months of pregnancy.
authors.affiliation: Kinderklinik der Johannes Gutenberg-Universität, Mainz, Federal Republic of Germany.
authors.forename: R
authors.initials: R
authors.lastname: Boor
authors.forename: R
authors.initials: R
authors.lastname: Rochels
authors.forename: B
authors.initials: B
authors.lastname: Walther
authors.forename: B
authors.initials: B
authors.lastname: Reitter
mesh_terms: D000140:Acidosis, Lactic / Q000150:complications*; D001921:Brain / Q000002:abnormalities / Q000000981:diagnostic imaging; D042967:Electron Transport Complex I; D004827:Epilepsy / Q000150:complications*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008928:Mitochondria / Q000201:enzymology; D009247:NADH, NADPH Oxidoreductases / Q000172:deficiency*; D009900:Optic Nerve / Q000002:abnormalities*; D012171:Retinal Vessels / Q000002:abnormalities*; D014057:Tomography, X-Ray Computed
chemical_list: D009247:NADH, NADPH Oxidoreductases; D042967:Electron Transport Complex I