CA-125 as a maternal serum marker for Down's syndrome in the first and second trimesters.
CA-125, alpha-fetoprotein (AFP), and human chorionic gonadotropin (HCG) were determined in maternal serum in the first trimester from 14 women with a Down's syndrome fetus and 61 women with a healthy fetus. In the second trimester, 15 and 60 serum samples were determined from women with a Down's syndrome and a healthy fetus respectively. In both trimesters, maternal serum CA-125 was found to be elevated in Down's syndrome pregnancies compared with controls. Using discrimination functions, our preliminary results indicate that CA-125 is a better marker than AFP and HCG respectively for a Down's syndrome fetus in the first trimester and improves the detection rate in the second trimester.
Høgdall
C K
CK
Department of Gynaecology and Obstetrics, Rigshospitalet, University of Copenhagen, Denmark.
Høgdall
E V
EV
Arends
J
J
Nørgaard-Pedersen
B
B
Smidt-Jensen
S
S
Larsen
S O
SO
D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D006063:Chorionic Gonadotropin / Q000097:blood; D004314:Down Syndrome / Q000175:diagnosis*; D005260:Female; D006801:Humans; D011247:Pregnancy / Q000097:blood*; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D000509:alpha-Fetoproteins / Q000032:analysis
D015295:Antigens, Tumor-Associated, Carbohydrate; D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins