Retinal regeneration.
The goal of research on neural regeneration is to restore brain function following injury. To many, this suggests regrowing damaged axons and re-establishing the interrupted pathways. A second, but little studied aspect of brain regeneration, is the replacement of lost neurons. For example, in some animals the neural retina is reconstituted by regenerative neurogenesis following its partial or total destruction. Two separate processes underlying retinal regeneration have been described: transdifferentiation of retinal pigmented epithelial cells into retinal neural progenitors (in adult urodeles, tadpoles, and embryonic chickens), and alteration in the fate of photoreceptor progenitors intrinsic to the retina (in adult fish).
Hitchcock
P F
PF
Dept of Anatomy and Cell Biology, W.K. Kellogg Eye Center, University of Michigan, School of Medicine, Ann Arbor 48105.
Raymond
P A
PA
D000818:Animals; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D012160:Retina / Q000502:physiology*