Isolation of sesbanimide from the seed of Sesbania vesicaria.
1. The HPLC separation of a water-soluble toxic fraction isolated from the seed of Sesbania vesicaria provided a potent antileukemic compound which was identified as sesbanimide (or sesbanimide A). The identity was established by comparison of the proton magnetic resonance spectra of the isolated sesbanimide and the authentic sample. 2. The IC50 value determined by the activity against the growth of murine leukemia (L1210) cells in vitro was 0.8 ng/ml.
Kim
H L
HL
Department of Veterinary Physiology and Pharmacology, Texas A & M University, College Station 77843.
Krakoff
I H
IH
Newman
R A
RA
D000470:Alkaloids; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004187:Disaccharides / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007939:Leukemia L1210 / Q000473:pathology; D051379:Mice; D010880:Piperidines / Q000302:isolation & purification* / Q000494:pharmacology; D010947:Plants, Toxic / Q000737:chemistry*; D013781:Texas; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D004187:Disaccharides; D010880:Piperidines; C077293:sesbanimide