[Interactions between peptides and major histocompatibility complex molecules].
T-cell receptors recognize foreign proteins as peptide fragments associated with major histocompatibility complex (MHC) molecules. Properties of antigenic peptides, methods for detecting peptide-MHC molecule combinations, and the characteristics of the interaction are reviewed. Possible explanations for graft rejection and autoimmune disease are suggested in the light of these data.
Choppin
J
J
INSERM U 152, Institut Cochin de Génétique Moléculaire, Hôpital Cochin, Paris, France.
D001172:Arthritis, Rheumatoid / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology; D003920:Diabetes Mellitus / Q000276:immunology; D004347:Drug Interactions / Q000276:immunology; D000939:Epitopes / Q000276:immunology* / Q000302:isolation & purification; D015395:Histocompatibility Antigens Class I / Q000276:immunology* / Q000302:isolation & purification; D000949:Histocompatibility Antigens Class II / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D010455:Peptides / Q000737:chemistry / Q000276:immunology*; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000276:immunology
D000939:Epitopes; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D010455:Peptides