Lymphoid tissue responses to concentrated perfluorochemical emulsions in rats.
The effects of injecting perfluorochemical (PFC) emulsions of varying concentrations on lymphoid tissues have been studied in rats. Tissue weights were increased in proportion with quantity of PFC injected, with spleen responses consistently greater than those of the liver. PFC droplets recovered from tissues had mean diameters in the 1-10 microns range, with those from the spleen being larger than from the liver. Recovered droplet diameters were considerably greater than freshly-prepared emulsion mean particle sizes (0.20-0.25 microns). This suggests that coalescence of emulsion droplets following accumulation in tissues is a pre-requisite to the eventual excretion of PFC vapour through the lungs.
Bentley
P K
PK
Department of Life Science, University of Nottingham, U.K.
Johnson
O L
OL
Washington
C
C
Lowe
K C
KC
D000818:Animals; D001802:Blood Substitutes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004655:Emulsions; D005466:Fluorocarbons / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008099:Liver / Q000033:anatomy & histology / Q000378:metabolism; D008221:Lymphoid Tissue / Q000033:anatomy & histology / Q000378:metabolism*; D008297:Male; D009929:Organ Size; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000033:anatomy & histology / Q000378:metabolism
D001802:Blood Substitutes; D004655:Emulsions; D005466:Fluorocarbons; C050455:fluosol