Ovarian mucinous cystadenocarcinoma producing alpha-fetoprotein. A case report.
A 62-year-old woman with a complaint of abdominal distention underwent surgery to remove a tumor in her left ovary. The serum alpha-fetoprotein (AFP) level was 4,130 ng/ml. Histologically, the tumor was diagnosed as a mucinous cystadenocarcinoma with a small area of solid proliferation of tumor cells. The cells of the latter part were shown immunohistochemically to possess AFP. We suppose that a part of the mucinous cystadenocarcinoma dedifferentiates and produces AFP.
Nomura
K
K
Department of Pathology, Jikei University School of Medicine, Tokyo, Japan.
Miyasaka
Y
Y
Murae
M
M
Terashima
Y
Y
Aizawa
S
S
D001344:Autopsy; D003536:Cystadenocarcinoma / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008853:Microscopy; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology*; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
D000509:alpha-Fetoproteins