[Anorexia nervosa with neutropenia--response of neutrophils to G-CSF].
A 50-year-old woman with anorexia nervosa was admitted for evaluation of neutropenia (WBC 1,600/microliters). Her bone marrow was gelatinous, and myeloid cells had decreased. Homogeneous substance deposited in the marrow, stained by alcian blue (pH 2.5), indicative of acid mucopolysaccharides. CFU-G and CFU-GM were decreased in number and myeloid pool in the bone marrow also decreased. Anti-neutrophilic antibody was negative. Neutropenia may be related to myeloid hypoplasia, due to increase of acid mucopolysaccharides replacing adipose cells in the bone marrow under long-term mal-nutritional state. Neutrophils markedly increased by administration of rhG-CSF 5.0 micrograms/kg/day for 14 days without the first peak. Serum G-CSF level did not increase (less than 60 pg/ml). It is effective to administer G-CSF to anorexia nervosa with neutropenia.
Muraki
Y
Y
Institute of Clinical Medicine, University of Tsukuba.
Kobayashi
T
T
Kojima
H
H
Shibuya
A
A
Nagasawa
T
T
Abe
T
T
Mori
N
N
D000856:Anorexia Nervosa / Q000097:blood* / Q000628:therapy; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007958:Leukocyte Count; D008875:Middle Aged; D009503:Neutropenia / Q000628:therapy*; D009504:Neutrophils / Q000502:physiology
D016179:Granulocyte Colony-Stimulating Factor