Human interleukin-1 receptor antagonist is expressed in liver.
Using PCR and Northern blot analysis, an IL-1 receptor antagonist specific transcript was amplified from HepG2- and liver mRNA. cDNA clones coding for IL-1 receptor antagonist were isolated from a liver cDNA library and sequence comparison revealed complete identity with the secreted, monocytic form of IL-1 receptor antagonist.
Steinkasserer
A
A
Department of Biochemistry, University of Oxford, UK.
Estaller
C
C
Weiss
E H
EH
Sim
R B
RB
D015152:Blotting, Northern; D002460:Cell Line; D004247:DNA; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism*; D008099:Liver / Q000737:chemistry*; D016133:Polymerase Chain Reaction; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D012313:RNA / Q000235:genetics; D011971:Receptors, Immunologic / Q000378:metabolism; D017472:Receptors, Interleukin-1; D012795:Sialoglycoproteins; D014158:Transcription, Genetic
C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D011506:Proteins; D011971:Receptors, Immunologic; D017472:Receptors, Interleukin-1; D012795:Sialoglycoproteins; D012313:RNA; D004247:DNA