title: Prevention of rheumatic fever in Costa Rica.
abstract: During the beginning of the 1970s, major changes occurred in Costa Rica in the treatment of streptococcal throat infections. Because of poor compliance with regimens using orally administered agents, intramuscular administration of benzathine penicillin was selected as the standard treatment and throat cultures were eliminated as a prerequisite for prescribing antibiotics. A decline in the incidence of rheumatic fever then occurred. We believe that similar health intervention could be applied in other developing countries.
authors.affiliation: Department of Pediatric Infectious Diseases, National Children's Hospital, San José, Costa Rica.
authors.forename: A
authors.initials: A
authors.lastname: Arguedas
authors.forename: E
authors.initials: E
authors.lastname: Mohs
mesh_terms: D003364:Costa Rica / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007273:Injections, Intramuscular; D010401:Penicillin G Benzathine / Q000008:administration & dosage / Q000627:therapeutic use*; D010612:Pharyngitis / Q000188:drug therapy* / Q000382:microbiology; D012213:Rheumatic Fever / Q000453:epidemiology / Q000517:prevention & control*; D013290:Streptococcal Infections / Q000188:drug therapy*; D013292:Streptococcus agalactiae
chemical_list: D010401:Penicillin G Benzathine