title: Effect of acute zinc deficiency on insulin receptor binding in rat adipocytes.
abstract: Considerable data have been reported on the relationship between insulin resistance and zinc deficiency. In this study, insulin receptor binding was measured in isolated rat adipocytes. Two assays were carried out at 37 degrees C (binding and internalization) and 16 degrees C (binding) using 125I insulin 0.05-20 nM. A decreased insulin receptor binding was observed in zinc-deficient rat adipocytes, but we could not make any distinction between the specific zinc depletion effects and the effects of the caloric restriction induced by zinc deficiency.
authors.affiliation: Laboratoire de Biochimie C, Hôpital A. Michallon, Grenoble, France.
authors.forename: M J
authors.initials: MJ
authors.lastname: Gomot
authors.forename: P
authors.initials: P
authors.lastname: Faure
authors.forename: A M
authors.initials: AM
authors.lastname: Roussel
authors.forename: C
authors.initials: C
authors.lastname: Coudray
authors.forename: M
authors.initials: M
authors.lastname: Osman
authors.forename: A
authors.initials: A
authors.lastname: Favier
mesh_terms: D000273:Adipose Tissue / Q000166:cytology / Q000378:metabolism* / Q000648:ultrastructure; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D007328:Insulin / Q000378:metabolism; D007457:Iodine Radioisotopes; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011972:Receptor, Insulin / Q000378:metabolism*; D015032:Zinc / Q000172:deficiency* / Q000378:metabolism
chemical_list: D007328:Insulin; D007457:Iodine Radioisotopes; D011972:Receptor, Insulin; D015032:Zinc