Effect of emulsion concentration on biodistribution of perflubron in tumor-bearing mice.
Perflubron (perfluoroocytlbromide, PFOB) emulsion concentrations of 100%, 90%, or 60% w/v were administered to mice with and without 3 types of murine malignant tumor implants, and the distribution in blood, tumor, lung, liver and spleen were studied 48 hours after a dose of 10 or 3 g/Kg of PFOB. The most important changes were seen in the blood where the PFOB concentration [PFOB] was decreased in tumor bearing mice (TBM). Blood [PFOB] was also decreased in TBM and normal mice (NM) that received the 60% emulsion. Liver [PFOB] was increased in TBM. Lung [PFOB] was directly proportional to the emulsion concentration with the 10g/Kg dose. No major differences were seen in the biodistribution between the 100% and 90% emulsions using 10g/Kg, in spite of differences in composition and manufacturing history.
Long
D M
DM
University of California, San Diego Department of Radiology 92103.
Witt
B L
BL
Escobar
J A
JA
Long
R A
RA
D000818:Animals; D001802:Blood Substitutes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003287:Contrast Media / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004655:Emulsions; D005466:Fluorocarbons / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006842:Hydrocarbons, Brominated; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000378:metabolism* / Q000628:therapy; D014018:Tissue Distribution
D001802:Blood Substitutes; D003287:Contrast Media; D004655:Emulsions; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; C003072:perflubron