Pulsed static magnetic field effects on in-vitro pineal indoleamine metabolism.
In-vitro rat pineal glands stimulated with the beta-adrenergic receptor agonist isoproterenol to induce melatonin synthesis and exposed for 1 h to a pulsed 0.4-G static magnetic field demonstrated significant inhibition of serotonin-N-acetyltransferase activity and melatonin content. 2-h exposure to pulsed magnetic field also resulted in a significant reduction in isoproterenol-induced serotonin-N-acetyltransferase activity. These results support the idea that the cultured pineal gland can be affected directly by artificially generated weak magnetic fields.
Richardson
B A
BA
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284-7762.
Yaga
K
K
Reiter
R J
RJ
Morton
D J
DJ
D000818:Animals; D001191:Arylamine N-Acetyltransferase / Q000037:antagonists & inhibitors; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D066298:In Vitro Techniques; D007211:Indoles / Q000378:metabolism*; D007545:Isoproterenol / Q000494:pharmacology; D008280:Magnetics; D008297:Male; D008550:Melatonin / Q000096:biosynthesis; D010870:Pineal Gland / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism
D007211:Indoles; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; C067042:indolamine; D001191:Arylamine N-Acetyltransferase; D008550:Melatonin; D007545:Isoproterenol