title: A recombination event that redefines the Huntington disease region.
abstract: We report both a recombination event that places the Huntington disease gene proximal to the marker D4S98 and an extended linkage-disequilibrium study that uses this marker and confirms the existence of disequilibrium between it and the HD locus. We also report the cloning of other sequences in the region around D4S98, including a new polymorphic marker R10 and conserved sequences that identify a gene in the region of interest.
authors.affiliation: Department of Medical Genetics, University of Wales College of Medicine, Cardiff, United Kingdom.
authors.forename: R G
authors.initials: RG
authors.lastname: Snell
authors.forename: L M
authors.initials: LM
authors.lastname: Thompson
authors.forename: D A
authors.initials: DA
authors.lastname: Tagle
authors.forename: T L
authors.initials: TL
authors.lastname: Holloway
authors.forename: G
authors.initials: G
authors.lastname: Barnes
authors.forename: H G
authors.initials: HG
authors.lastname: Harley
authors.forename: L A
authors.initials: LA
authors.lastname: Sandkuijl
authors.forename: M E
authors.initials: ME
authors.lastname: MacDonald
authors.forename: F S
authors.initials: FS
authors.lastname: Collins
authors.forename: J F
authors.initials: JF
authors.lastname: Gusella
mesh_terms: D002894:Chromosomes, Human, Pair 4; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D006816:Huntington Disease / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D010375:Pedigree; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic; D015183:Restriction Mapping
chemical_list: D005819:Genetic Markers