Recurrent chromosome alterations in transitional cell bladder carcinomas.
A karyotype study was performed in 42 cases of transitional cell bladder carcinoma. The results, confirmed by DNA content evaluation, showed a prevalence of near-diploid modes not related to the histologic grade of differentiation. Nonrandom alterations were represented by monosomy of chromosome 13 and 22, trisomy of chromosome 7 and deletion of chromosomes 6 and 11. These anomalies allow the identification of different sub-groups of tumors, each with its own biological characteristics of aggressiveness. Prognosis was particularly poor in cases with monosomy of chromosomes 13 and 22 but more favourable in poorly differentiated carcinomas with trisomy of chromosome 7.
Matturri
L
L
Institute of Pathological Anatomy, University of Milan, Italy.
Lavezzi
A M
AM
D002295:Carcinoma, Transitional Cell / Q000648:ultrastructure*; D002869:Chromosome Aberrations; D006801:Humans; D007621:Karyotyping; D013194:Staining and Labeling; D001749:Urinary Bladder Neoplasms / Q000648:ultrastructure*