[Study of the antigenic structure of human immunodeficiency virus using synthetic peptides].
In a search for synthetic peptide antigens fit to detect anti-HIV antibodies, a set of algorithms were used to predict the probable antigenic determinants of gag, pol, env and nef proteins of HIV-1 and HIV-2. Over forty peptides were synthesized by the solid-phase method. The reactivity of the peptide antigens was evaluated in ELISA on panels of HIV-1/2-positive sera. Application of the synthetic peptides for the early HIV diagnostics was examined.
Ivanov
V S
VS
Chikin
L D
LD
Suvorova
Z K
ZK
Kozhich
A T
AT
Ivanov
V T
VT
D000595:Amino Acid Sequence; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000276:immunology*; D015686:Gene Products, env / Q000276:immunology; D015683:Gene Products, gag / Q000276:immunology; D015693:Gene Products, nef / Q000276:immunology; D015684:Gene Products, pol / Q000276:immunology; D015752:Genes, env; D015750:Genes, gag; D015754:Genes, nef; D015751:Genes, pol; D015483:HIV Antibodies / Q000032:analysis*; D015497:HIV-1 / Q000276:immunology*; D015498:HIV-2 / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D054311:nef Gene Products, Human Immunodeficiency Virus
D000939:Epitopes; D015686:Gene Products, env; D015683:Gene Products, gag; D015693:Gene Products, nef; D015684:Gene Products, pol; D015483:HIV Antibodies; D054311:nef Gene Products, Human Immunodeficiency Virus