Regulation of estrogen sulfotransferase by estrogen in MCF-7 human mammary cancer cells.
The importance of the steroid hormone microenvironment within cells is now recognised in studies on endocrine-related neoplasms such as breast cancer. This focuses attention on enzymes which control the intracellular levels of estradiol-17 beta (E2). One such enzyme, estrogen sulfotransferase, which converts E2 to inactive E2-3 sulfate, has now been shown to be regulated by estrogen in MCF-7 human mammary cancer cells. Hydroxysteroid sulfotransferase, which sulfurylates the adrenal-derived estrogen 5-androstene-3 beta,17 beta-diol, is also under estrogen control. Evidence is provided which shows that one function of these enzymes may involve elimination of estrogen from the cell following processing of the ligand-charged estrogen receptor (ER).
Adams
J B
JB
School of Biochemistry, University of New South Wales, Sydney, Australia.
Vrahimis
R
R
Phillips
N
N
D001943:Breast Neoplasms / Q000201:enzymology*; D003609:Dactinomycin / Q000494:pharmacology; D004717:Endometrium / Q000201:enzymology; D004958:Estradiol / Q000502:physiology*; D005260:Female; D006801:Humans; D011960:Receptors, Estrogen / Q000032:analysis; D015238:Sulfotransferases; D013466:Sulfurtransferases / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D011960:Receptors, Estrogen; D003609:Dactinomycin; D004958:Estradiol; D013466:Sulfurtransferases; D015238:Sulfotransferases; C028152:alcohol sulfotransferase; C020122:estrone sulfotransferase