Brief visual experience induces immediate early gene expression in the cat visual cortex.
Brief visual experience causes rapid physiological changes in the visual cortex during early postnatal development. A possible mediator of these effects is the immediate early genes whose protein products are involved in the rapid response of neurons to transsynaptic stimulation. Here we report evidence that the levels of immediate early gene mRNAs in the visual cortex can be altered by manipulating the visual environment. Specifically, we find that brief (1 h) visual experience in dark-reared cats causes dramatic transient inductions of egr1, c-fos, and junB mRNAs in the visual cortex but not in the frontal cortex. Levels of c-jun and c-myc mRNAs are unaffected. These results suggest that select combinatorial interactions of immediate early gene proteins are an important step in the cascade of events through which visually elicited activity controls visual cortical development.
Rosen
K M
KM
Massachusetts General Hospital, Department of Neurobiology, Harvard Medical School, Boston 02129.
McCormack
M A
MA
Villa-Komaroff
L
L
Mower
G D
GD
D000818:Animals; D015152:Blotting, Northern; D002415:Cats; D004268:DNA-Binding Proteins / Q000235:genetics; D003624:Darkness; D005625:Frontal Lobe / Q000502:physiology*; D015870:Gene Expression; D005809:Genes, Regulator; D016758:Genes, jun; D016259:Genes, myc; D008027:Light; D012313:RNA / Q000235:genetics / Q000302:isolation & purification; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D015183:Restriction Mapping; D014157:Transcription Factors / Q000235:genetics; D014785:Vision, Ocular / Q000502:physiology*; D014793:Visual Cortex / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*; D016335:Zinc Fingers / Q000235:genetics
D004268:DNA-Binding Proteins; D012333:RNA, Messenger; D014157:Transcription Factors; D012313:RNA