Arterial blood gases and brain oxygen availability following infusion of intratracheal fluorocarbon neat liquids.
Eight adult New Zealand Swiss rabbits (3-5 kg) having previously implanted chronic bilateral platinum electrodes in the visual cerebral cortex and subcutaneous silver reference electrodes were tranquilized and monitored in multiple 2-3 hour sessions using voltammetric techniques. Six of these were given intratracheal neat liquid fluorocarbons ranging in boiling point from 132 degrees C to 215 degrees C at doses of 2 or 4cc/kg. Each animal received only one fluorocarbon liquid. Two additional rabbits were match-studied as controls. Half of the rabbits have survived more than five months. Both controls and two experimental rabbits were sacrificed after more than seven months due to gastric hairballs. The period of daytime monitoring sessions, when cathodic brain oxygen currents (aO2), arterial blood gases and pH were obtained, was between 34 and 263 days. In some animals the arterial pCO2 was increased during the first week but the pO2 and pH remained nearly normal in all eight animals throughout. The two best fluorocarbons for liquid breathing on the basis of this limited but intensive work are F-methyldecalin and F-5,6H-dec-5-ene (F44E).
Hoffmann
R E
RE
Children's Hospital Medical Center, Cincinnati, Ohio.
Bhargava
H K
HK
Davis
S L
SL
Clark
L C
LC
D000818:Animals; D001802:Blood Substitutes / Q000008:administration & dosage*; D001921:Brain / Q000378:metabolism; D002245:Carbon Dioxide / Q000097:blood; D005466:Fluorocarbons / Q000008:administration & dosage*; D010100:Oxygen / Q000097:blood / Q000378:metabolism*; D011817:Rabbits; D012119:Respiration; D014132:Trachea; D014835:Volatilization
D001802:Blood Substitutes; D005466:Fluorocarbons; D002245:Carbon Dioxide; D010100:Oxygen