title: Kinetics of particulate and solute marker passage in sheep supplemented with cationomycin and lasalocid antibiotics. Comparisons among methods for calculating mean retention time.
abstract: Passage of particulate and solute markers in the digestive tract was studied in sheep fed a roughage-pelleted diet supplemented or not with ionophore antibiotics. Methods of marker administration (continuous infusion vs pulse-dose) and mathematical treatment of data were investigated. Antibiotic supplementation did not affect markers' mean retention time (MRT) significantly, regardless of sampling site, technique of marker administration or MRT calculation methods used. The pulse dose technique led to 20-30% higher estimate of particle markers MRT in the entire gut and stomachs of sheep than did the continuous infusion method. Similar results were obtained between these methods for solute markers MRT at both sampling sites. Total MRT in the digestive tract could be partitioned among compartments using a deterministic model when applied to pulse-dose kinetics. Such a partitioning appeared unsatisfactory with continuous-infusion data. Estimations of particle or solute markers MRT in the rumen from duodenal and faecal marker kinetics were significantly different and rarely correlated.
authors.affiliation: NRA, Unité de la Digestion Microbienne, Theix, Saint-Genès-Champanelle, France.
authors.forename: L
authors.initials: L
authors.lastname: Gomez
authors.forename: J P
authors.initials: JP
authors.lastname: Lallès
authors.forename: C
authors.initials: C
authors.lastname: Bogaërt
authors.forename: C
authors.initials: C
authors.lastname: Poncet
mesh_terms: D000821:Animal Feed; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004063:Digestion; D005243:Feces / Q000737:chemistry; D005663:Furans / Q000494:pharmacology*; D005772:Gastrointestinal Transit / Q000187:drug effects*; D007700:Kinetics; D007832:Lasalocid / Q000494:pharmacology*; D012756:Sheep / Q000502:physiology*
chemical_list: D000900:Anti-Bacterial Agents; D005663:Furans; C022174:cationomycin; D007832:Lasalocid