Resolution of terfenadine enantiomers by beta-cyclodextrin chiral stationary phase high-performance liquid chromatography.
Enantiomers of terfenadine were resolved by high-performance liquid chromatography (HPLC) using a chiral stationary phase (CSP) column packed with beta-cyclodextrin (beta-CD) covalently bound to silica. Separation was achieved in both the reverse phase and normal phase modes. Resolution of enantiomers was confirmed by ultraviolet-visible absorption, circular dichroism, and mass spectral analysis.
Weems
H
H
Department of Pharmacology, Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine, Bethesda, Maryland 20814-4799.
Zamani
K
K
D002851:Chromatography, High Pressure Liquid; D003505:Cyclodextrins; D006863:Hydrogen-Ion Concentration; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D016593:Terfenadine / Q000302:isolation & purification* / Q000378:metabolism; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D047392:beta-Cyclodextrins; D016593:Terfenadine; C031215:betadex