title: Local botulinum toxin in the treatment of spastic drop foot.
abstract: Ten patients with spastic drop foot were treated by local injections of botulinum toxin A (botulinum toxin A haemagglutinin complex). The purpose was to improve stance and gait and/or to facilitate physiotherapy and patient care. Various calf muscles were injected using EMG guidance. The average dose used was 23 ng. Prior to and 4 weeks after treatment, positions of the upper and lower ankle joint at rest and the corresponding end positions of passive and active movement were determined. In addition, changes of spasticity and pain, the transmission phenomenon and stance and gait were evaluated. Most patients showed improvement of some aspects of the spastic drop foot. Positions of the upper and lower ankle joint were improved in most of the patients, as were the other parameters examined. Except for weakness of the injected muscles no side-effects were observed. The results appear promising and may be optimized in further trials by using higher doses of the toxin.
authors.affiliation: Neurologische Klinik der Universität, Bonn, Federal Republic of Germany.
authors.forename: R
authors.initials: R
authors.lastname: Dengler
authors.forename: U
authors.initials: U
authors.lastname: Neyer
authors.forename: K
authors.initials: K
authors.lastname: Wohlfarth
authors.forename: U
authors.initials: U
authors.lastname: Bettig
authors.forename: H H
authors.initials: HH
authors.lastname: Janzik
mesh_terms: D000293:Adolescent; D000328:Adult; D000843:Ankle Joint / Q000503:physiopathology*; D001905:Botulinum Toxins / Q000627:therapeutic use*; D004576:Electromyography; D005260:Female; D005528:Foot; D005684:Gait / Q000502:physiology; D006801:Humans; D007866:Leg; D008297:Male; D008875:Middle Aged; D009128:Muscle Spasticity / Q000188:drug therapy / Q000503:physiopathology; D010243:Paralysis / Q000188:drug therapy* / Q000503:physiopathology; D011187:Posture / Q000502:physiology; D016059:Range of Motion, Articular / Q000502:physiology
chemical_list: D001905:Botulinum Toxins