title: T cell-dependent antibody production by Ly-1 B cells.
abstract: Through the use of a SCID transfer system, we have demonstrated that under certain conditions, the production of Ig by Ly-1 B cells can be modulated by T cells. This modulation can take the form of enhanced isotype production or isotype-switch induction and to some extent appears to be dependent on the activation state of the T cells. Furthermore we have shown that Ly-1 B cells can mount an idiotypically restricted T cell-dependent immune response to the antigen PC-KLH. This result suggests that the previous failure to observe T cell-dependent responses by Ly-1 B cells has been due to these B cells being "blind" to the antigens used and is not due to some inherent property of these B cells. When one considers the previous reports of the substantial contribution of Ly-1 B cells to the natural serum immunoglobulin levels and the ability of T cells to affect Ig production by Ly-1 B cells documented in this report, it is clear that the interaction of T cells with the Ly-1 B-cell population is important in determining the "natural" serum Ig repertoire of the mouse.
authors.affiliation: Institute for Genetics, University of Cologne, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Taki
authors.forename: M
authors.initials: M
authors.lastname: Schmitt
authors.forename: D
authors.initials: D
authors.lastname: Tarlinton
authors.forename: I
authors.initials: I
authors.lastname: Förster
authors.forename: K
authors.initials: K
authors.lastname: Rajewsky
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology; D000917:Antibody Formation; D015703:Antigens, CD / Q000276:immunology*; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D015704:CD4 Antigens / Q000276:immunology; D018956:CD5 Antigens; D007070:Immunoglobulin A / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000145:classification; D007075:Immunoglobulin M / Q000096:biosynthesis; D016219:Immunotherapy, Adoptive; D051379:Mice; D016513:Mice, SCID; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000906:Antibodies; D015703:Antigens, CD; D015704:CD4 Antigens; D018956:CD5 Antigens; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M