title: The psychological effects of false-positive results in prenatal screening for fetal abnormality: a prospective study.
abstract: The purpose of the study was to describe the impact of false-positive results from initial maternal serum alpha-fetoprotein (MS-AFP) screening. The analyses compared two groups of women, those receiving a negative result (n = 346) and those receiving an initial positive result (n = 26), over four time points--prior to testing, immediately after testing, later in pregnancy, and in the post-partum period. Receiving an abnormal result was associated with high levels of anxiety which were reflected in increased worry about the baby's health and a more negative attitude towards the pregnancy and the baby. Women who had an initial abnormal result were offered a variety of further tests. Those women who went on to have amniocentesis were less worried about their baby's health in the third trimester and also less anxious post-partum than those who did not have amniocentesis. In view of the increasing number of screening tests available, it is necessary to establish whether and how these levels of distress can best be reduced.
authors.affiliation: Psychology Unit, Royal Free Hospital School of Medicine, London, U.K.
authors.forename: T M
authors.initials: TM
authors.lastname: Marteau
authors.forename: R
authors.initials: R
authors.lastname: Cook
authors.forename: J
authors.initials: J
authors.lastname: Kidd
authors.forename: S
authors.initials: S
authors.lastname: Michie
authors.forename: M
authors.initials: M
authors.lastname: Johnston
authors.forename: J
authors.initials: J
authors.lastname: Slack
authors.forename: R W
authors.initials: RW
authors.lastname: Shaw
mesh_terms: D000328:Adult; D000649:Amniocentesis / Q000523:psychology; D001007:Anxiety / Q000209:etiology; D005189:False Positive Reactions; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis*; D006801:Humans; D008137:Longitudinal Studies; D011247:Pregnancy / Q000097:blood / Q000523:psychology*; D011296:Prenatal Diagnosis / Q000523:psychology*; D011446:Prospective Studies; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000509:alpha-Fetoproteins