ATP-dependent bacterial transporters and cystic fibrosis: analogy between channels and transporters.
The traffic ATPases superfamily includes known transporters, both prokaryotic and eukaryotic, including the medically important proteins, P-glycoprotein, and the cystic fibrosis gene product (CFTR), which is known to be a Cl- channel. The structure and mechanism of action of the best-studied members of the superfamily, the periplasmic permeases, are described and related to that of CFTR and eukaryotic traffic ATPases in general. The contention is put forward that the distinction between the architecture and mechanisms of action of channels and transporters is blurred.
Ames
G F
GF
Department of Molecular Biology, University of California, Berkeley 94720.
Lecar
H
H
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000595:Amino Acid Sequence; D005075:Biological Evolution; D001693:Biological Transport, Active; D002352:Carrier Proteins / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism; D003550:Cystic Fibrosis / Q000378:metabolism*; D007473:Ion Channels / Q000737:chemistry* / Q000378:metabolism; D008969:Molecular Sequence Data
D002352:Carrier Proteins; D007473:Ion Channels; D000255:Adenosine Triphosphate