Bioavailability of oral isbufylline in rabbits.
The bioavailability of isbufylline was assessed in male rabbits given 12 mg/kg i.v. (intravenous) or per os (oral) according to a randomized design. The concentrations of unbound (fu = 54.0) isbufylline were considered in plasma as a function of time, after i.v. and oral administration. After oral administration in saline solution, a mean absolute oral bioavailability of 59.6% was calculated. The drug is rapidly absorbed and the comparison of the kinetic profiles after i.v. and per os administration, revealed a rapid elimination: t1/2 27.3 and 28.8 min respectively, and a total body clearance of 67.06 ml/min/kg. Urinary recovery 0-48 h accounted for less than 1% of the dose.
Celardo
A
A
Istituto Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, S. Maria Imbaro, Italy.
Dell'Elba
G
G
Bonati
M
M
D015056:1-Methyl-3-isobutylxanthine / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D000818:Animals; D001682:Biological Availability; D001798:Blood Proteins / Q000378:metabolism; D001993:Bronchodilator Agents / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D011485:Protein Binding; D011817:Rabbits
D001798:Blood Proteins; D001993:Bronchodilator Agents; C058878:isbufylline; D015056:1-Methyl-3-isobutylxanthine