Prolonged intravenous urokinase infusion: an alternative pharmacologic approach in the treatment of thrombus-containing saphenous vein graft stenoses.
A subtotally occlusive saphenous vein graft stenosis resolved after rapid intracoronary and prolonged intravenous urokinase infusion. Additional therapy was unnecessary, avoiding the attendant risks of saphenous vein graft angioplasty. Combined intracoronary and intravenous urokinase infusion should be considered prior to coronary angioplasty of saphenous vein graft stenoses, particularly when diffuse degeneration is present or the risk of underlying thrombus is high.
Cospito
P D
PD
Angiographic Core Laboratory, Washington Cardiology Center, Washington, D.C. 20010.
Popma
J J
JJ
Satler
L F
LF
Leon
M B
MB
Kent
K M
KM
Pichard
A D
AD
D015906:Angioplasty, Balloon, Coronary; D001026:Coronary Artery Bypass; D006083:Graft Occlusion, Vascular / Q000188:drug therapy* / Q000628:therapy; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D012501:Saphenous Vein / Q000473:pathology / Q000637:transplantation*; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000188:drug therapy* / Q000628:therapy; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*
D014568:Urokinase-Type Plasminogen Activator