title: Inter-alpha-trypsin inhibitor-related immunoreactivity in human tissues and body fluids.
abstract: The distribution of inter-alpha-trypsin inhibitor (ITI) and related inhibitors was investigated in normal human tissues and body fluids by using an enzyme-linked immunosorbent assay (ELISA) and a streptavidin-biotin-peroxidase immunohistochemical technique. ITI-related immunoreactivity was localized in different cell types of various organs, such as liver, kidney, testis, gross intestine, cutis and brain. Specific immunoreactivity was also detected in serum, urine and bronchial mucus. This widespread, but not ubiquitous pattern of localization suggests that, in addition to the well known plasmatic role, ITI and/or ITI-related inhibitors may play a number of different physiological roles in various human tissues.
authors.affiliation: Department of Cardiovascular Sciences, University, La Sapienza, Rome, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Businaro
authors.forename: F M
authors.initials: FM
authors.lastname: Leali
authors.forename: G
authors.initials: G
authors.lastname: De Renzis
authors.forename: E
authors.initials: E
authors.lastname: Pompili
authors.forename: G
authors.initials: G
authors.lastname: Pagliari
authors.forename: G
authors.initials: G
authors.lastname: Menghi
authors.forename: L
authors.initials: L
authors.lastname: Fumagalli
mesh_terms: D000328:Adult; D000510:Alpha-Globulins / Q000032:analysis* / Q000652:urine; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D009928:Organ Specificity; D015842:Serine Proteinase Inhibitors / Q000032:analysis* / Q000097:blood / Q000652:urine
chemical_list: D000510:Alpha-Globulins; D015842:Serine Proteinase Inhibitors; C011877:inter-alpha-inhibitor