title: Intra-articular injection pentosanpolysulphate results in increased hyaluronan molecular weight in joint fluid.
abstract: The influence of an oversulphated glycosaminoglycan, pentosanpolysulphate, on hyaluronan metabolism of the synovial lining cell was studied in vivo in human volunteers. Significant increases in the mean degree of polymerisation of the hyaluronan chains were observed after a series of four to six intra-articular injections of this glycosaminoglycan. No increases in hyaluronan synthesis rates were observed. Repeated administration of the drug did not cause any inflammation or bleeding in the joint cavity.
authors.affiliation: Department of Rheumatology, University Hospital, Ghent, Belgium.
authors.forename: G
authors.initials: G
authors.lastname: Verbruggen
authors.forename: E M
authors.initials: EM
authors.lastname: Veys
mesh_terms: D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry / Q000378:metabolism*; D007270:Injections, Intra-Articular; D008970:Molecular Weight; D010426:Pentosan Sulfuric Polyester / Q000008:administration & dosage / Q000494:pharmacology*; D013582:Synovial Fluid / Q000378:metabolism*; D014783:Viscosity / Q000187:drug effects
chemical_list: D010426:Pentosan Sulfuric Polyester; D006820:Hyaluronic Acid