[Mechanisms of protective action of radix Salviae miltiorrhizae (RSM) against experimental hepatic injury in rats].
The results indicated that RSM could significantly inhibit the lipid peroxidation of normal livers and cultured hepatocytes of rats, induce liver microsomal cytochrome P450 in normal rats, increase nucleic acids, proteins, urea and cerolloplasmin of damaged cultured hepatocytes of rats, relieve ultrastructural damage of cultured hepatocytes induced by CCl4. The pharmacological actions mentioned above should be considered as important mechanisms of RSM against liver injury.
Deng
H
H
Shanxi Medical College, Taiyuan.
Ma
X
X
Xu
R
R
Chen
X
X
Zhao
Y
Y
Yin
L
L
Han
D
D
D000818:Animals; D002251:Carbon Tetrachloride; D002478:Cells, Cultured; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D010936:Plant Extracts; D012313:RNA / Q000378:metabolism; D051381:Rats; D027561:Salvia miltiorrhiza
D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D008315:Malondialdehyde; D012313:RNA; D004247:DNA; D003577:Cytochrome P-450 Enzyme System; D002251:Carbon Tetrachloride