The cultured diploid fibroblast as a model for the study of cellular aging.
The limited proliferative potential of the cultured human diploid fibroblast is now well established. A number of biological correlates suggest that this culture system is a model for the study of aging at the cellular level. The mechanism(s) that causes the loss of proliferative activity is unknown; the results of some recent studies indicate that specific genes may play a pivotal role in cellular aging in vitro. The extent to which changes in proliferative functions are causally related to aging in vivo is currently under investigation.
Norwood
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TH
Department of Pathology, University of Washington, Seattle 98195.
Pendergrass
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WR
D002478:Cells, Cultured; D016922:Cellular Senescence / Q000502:physiology*; D004171:Diploidy; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology*; D006801:Humans; D008954:Models, Biological