title: Modulation of acute phase protein synthesis in cultured rat hepatocytes by human recombinant hepatocyte growth factor.
abstract: Human recombinant hepatocyte growth factor (HGF) added to primary cultures of rat hepatocytes stimulates synthesis of some acute phase proteins, especially alpha-2-macroglobulin. As indicated by changes in mRNA abundance HGF increases alpha-2-macroglobulin production at the pretranslational level. Interleukin-6, the main acute-phase cytokine, does not show synergy with HGF in enhancing synthesis of alpha-2-macroglobulin, and inhibits HGF-induced DNA-synthesis. On the other hand, dexamethasone potentiates the effects of HGF on synthesis of DNA and acute phase proteins by cultured rat hepatocytes.
authors.affiliation: Institute of Molecular Biology, Jagiellonian University, Krakow, Poland.
authors.forename: P
authors.initials: P
authors.lastname: Pierzchalski
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Takehara
authors.forename: A
authors.initials: A
authors.lastname: Koj
mesh_terms: D000209:Acute-Phase Proteins / Q000096:biosynthesis*; D000818:Animals; D002478:Cells, Cultured; D003907:Dexamethasone / Q000494:pharmacology; D017228:Hepatocyte Growth Factor / Q000502:physiology*; D015850:Interleukin-6 / Q000502:physiology; D008099:Liver / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins / Q000494:pharmacology
chemical_list: D000209:Acute-Phase Proteins; D015850:Interleukin-6; D011994:Recombinant Proteins; D017228:Hepatocyte Growth Factor; D003907:Dexamethasone