Cardiac myxoma with a cytokeratin-immunoreactive glandular component.
This study documents the expression of cytokeratin intermediate filaments (IFs) in a surgically excised glandular atrial myxoma. The glandular structures showed also positivity for carcinoembryonic antigen. Typical isolated or cordlike myxoma cells contained vimentin IFs. Positivity for von Willebrand factor was detected in cells lining deep invaginations of surface papillae and vascular channels. Bundles of smooth muscle cells and myofibroblasts scattered throughout the myxoid matrix synthesized the isoform of alpha-actin specific for smooth muscle.
Schmitt-Gräff
A
A
Department of Pathology, University Medical Center, Geneva, Switzerland.
Borchard
F
F
D006325:Heart Atria; D006338:Heart Neoplasms / Q000737:chemistry*; D006801:Humans; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000032:analysis*; D007633:Keratins / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009232:Myxoma / Q000737:chemistry*; D014841:von Willebrand Factor / Q000032:analysis
D007381:Intermediate Filament Proteins; D014841:von Willebrand Factor; D007633:Keratins