[Thymectomy and splenectomy of adult mice have no influence on the level of suppressor activity of T-lymphocytes specific to antigens of H-2 complex].
I.v. immunization of mice with irradiated (1500 rad) allogeneic spleen cells induces T cells specific to histocompatibility antigens and capable to suppress proliferation in mixed lymphocyte cultures. The lymph node cells appeared to be almost as capable as spleen cells of producing suppression. Splenectomy experiments showed that the spleen is not essential for induction of suppressive activity of T cells. The precursors of T cells with suppressive activity do not belong to the pool of short-living cells as they are insensitive to adult thymectomy, produced 6 weeks before immunization.
Kronin
V V
VV
Anosova
N G
NG
D000367:Age Factors; D000818:Animals; D006183:H-2 Antigens / Q000276:immunology*; D007114:Immunization; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D013154:Spleen / Q000276:immunology / Q000502:physiology; D013156:Splenectomy; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D013934:Thymectomy; D013997:Time Factors
D006183:H-2 Antigens