Nitric oxide participation in renal hemodynamic effect of angiotensin converting enzyme inhibitor lisinopril.
Nitric oxide (NO) contribution to the renal hemodynamic effect of lisinopril was assessed in anesthetized rabbits. NG-Nitro-L-arginine (NArg), slightly decreased renal blood flow following vehicle. Also, NArg reversed partially the increase in renal blood flow caused by DuP 753, and almost completely reversed the effect of lisinopril. The results suggest that NO plays an important role in the renal hemodynamic effect of lisinopril, more so than its contribution to the effect of DuP 753.
Hajj-ali
A F
AF
Department of Pharmacology, University of Minnesota, Minneapolis 55455.
Zimmerman
B G
BG
D000594:Amino Acid Oxidoreductases / Q000037:antagonists & inhibitors; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D004656:Enalapril / Q000031:analogs & derivatives* / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D017706:Lisinopril; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase; D019335:Nitroarginine; D011817:Rabbits; D012079:Renal Circulation / Q000187:drug effects*
D000806:Angiotensin-Converting Enzyme Inhibitors; D019335:Nitroarginine; D009569:Nitric Oxide; D004656:Enalapril; D001120:Arginine; D017706:Lisinopril; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases