Mutagenic activity of a series of synthetic and naturally occurring heterocyclic amines in Salmonella.
26 synthetic and naturally occurring heterocyclic amines were tested in the Salmonella/microsome assay (Ames test) using tester strains TA98 and TA100 in the presence of an Aroclor-induced rat-liver S9 fraction. 9 of the compounds were protein-pyrolysis products which had previously been shown to be mutagenic. Mutagenic potencies similar to previously reported values were demonstrated for these compounds with the exception that Trp-P-1 was only mutagenic in strain TA98 in our study, although it had previously been reported to be weakly mutagenic in strain TA100. 17 structurally diverse heterocyclic amines were synthesized and tested for mutagenicity. The structural diversity of these synthetic heterocyclic amines will enhance the sensitivity of future quantitative structure-activity relationship (QSAR) studies by demonstrating the structural characteristics essential for mutagenicity. The results of this study provide a large data base for the mutagenicity of this important class of compounds.
Smith
C
C
R.J. Reynolds Tobacco Company, Winston-Salem, NC 27102.
Payne
V
V
Doolittle
D J
DJ
Debnath
A K
AK
Lawlor
T
T
Hansch
C
C
D000588:Amines / Q000737:chemistry / Q000633:toxicity*; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000633:toxicity*; D015394:Molecular Structure; D009152:Mutagenicity Tests; D009153:Mutagens / Q000737:chemistry / Q000633:toxicity*; D012475:Salmonella / Q000187:drug effects
D000588:Amines; D006571:Heterocyclic Compounds; D009153:Mutagens