[Enhancement of bleomycin or hyperthermia induced tumor cell damage by ADPRT inhibitor].
Enhancement of tumor cell damage by ADPRT inhibitor, 3-aminobenzamide (3AB) was investigated. 3AB could inhibit DNA strand break repair in HeLa S3 cells after treatment with bleomycin. 3AB was able to lower the clonogenic ability of HeLa S3 cells after bleomycin treatment and hyperthermia. 3AB could also prevent potentially lethal damage repair (PLDR) in HeLa S3 cells treated with bleomycin. This work presents some experimental evidence and theoretical background for the possible use of 3AB as a sensitizer in the treatment of cancer.
Tao
H
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Institute of Radiation Medicine, Beijing.
D001549:Benzamides / Q000494:pharmacology*; D001761:Bleomycin / Q000494:pharmacology*; D004249:DNA Damage / Q000187:drug effects; D004260:DNA Repair / Q000187:drug effects*; D004273:DNA, Neoplasm / Q000235:genetics; D004357:Drug Synergism; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D014410:Tumor Stem Cell Assay
D001549:Benzamides; D004273:DNA, Neoplasm; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D001761:Bleomycin; C025160:3-aminobenzamide