title: The human APO-1 (APT) antigen maps to 10q23, a region that is syntenic with mouse chromosome 19.
abstract: The APO-1 (APT) antigen is a cell surface antigen expressed on a variety of normal and malignant cells. Binding of anti-APO-1 antibody to the APO-1 antigen induces programmed cell death (apoptosis). The APO-1 antigen shows homology to the members of the tumor necrosis factor receptor/nerve growth factor receptor superfamily. Using cosmid DNA containing the APO-1 gene as a probe for fluorescence in situ hybridization, we have mapped the gene to a subregion of chromosomal band 10q23. The human APO-1 locus lies within a conserved synteny segment present on mouse chromosome 19 consistent with the previous chromosomal assignment of the corresponding mouse antigen.
authors.affiliation: Forschungsschwerpunkt Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Heidelberg, Federal Republic of Germany.
authors.forename: P
authors.initials: P
authors.lastname: Lichter
authors.forename: H
authors.initials: H
authors.lastname: Walczak
authors.forename: S
authors.initials: S
authors.lastname: Weitz
authors.forename: I
authors.initials: I
authors.lastname: Behrmann
authors.forename: P H
authors.initials: PH
authors.lastname: Krammer
mesh_terms: D000951:Antigens, Neoplasm / Q000235:genetics*; D000954:Antigens, Surface / Q000235:genetics*; D017209:Apoptosis; D001483:Base Sequence; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10; D015342:DNA Probes; D006801:Humans; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D019014:fas Receptor
chemical_list: D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D015342:DNA Probes; D019014:fas Receptor