Cytogenetic and FISH studies of abnormal X chromosomes in a patient with ANLL.
We report a case of idic(X)(q13),r(X)(p22q13), and del(X)(:p11-->cen-->q11:) in a 71-year-old female patient with de novo acute nonlymphocytic leukemia (ANLL), FAB-M4. The abnormal X chromosomes of this patient were identified cytogenetically by G-banding technique and were further confirmed by fluorescence in situ hybridization (FISH) using an alpha-satellite probe to chromosome X centromere. The features of this are compared with other cases reported in the literature.
Chen
Z
Z
Cancer Center of SBRI and Genetrix, Inc., Scottsdale, AZ 85251.
Berger
C S
CS
Morgan
R
R
Roth
D
D
Stone
J F
JF
Sandberg
A A
AA
D000368:Aged; D002869:Chromosome Aberrations; D002999:Clone Cells; D005260:Female; D005453:Fluorescence; D006801:Humans; D017403:In Situ Hybridization / Q000379:methods; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D012303:Ring Chromosomes; D014960:X Chromosome