Modification of cell proliferation with inhibitors.
Recent developments on mechanisms that control cell multiplication, using molecular biology, are renewing interest in inhibitors and activators. A great deal of information has been gained in the past through the use of chemicals that modify passage through the cell cycle. The kinds of inhibitors, their sites of action that disrupt functions essential for proliferation, their usefulness in synchronizing cultures and, importantly, their therapeutic value, have been the subject of many investigations.
Pardee
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AB
Dana-Farber Cancer Institute, Boston, Massachusetts.
Keyomarsi
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K
D000818:Animals; D002455:Cell Division / Q000187:drug effects* / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis; D006801:Humans; D008563:Membrane Lipids / Q000378:metabolism; D010766:Phosphorylation; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis
D008563:Membrane Lipids; D012313:RNA; D004247:DNA