Effects of histamine H2-receptor antagonists and a proton pump inhibitor on the mucosal hydroxyproline content of ethanol-HCl-induced gastric lesions in rats.
We evaluated the effects of different antisecretory agents (H2-receptor antagonists and a proton pump inhibitor) on collagen regeneration in rat gastric lesions induced by intragastric administration of 50% ethanol +0.15 N HCl (EtOH-HCl). The lesion indices showed the highest value 30 min after administration of EtOH-HCl and a significantly decreased value 15 h later. The mucosal hydroxyproline concentration was significantly increased 30 min after EtOH-HCl administration, reached a maximum 6 h later and subsequently decreased as time passed. Intraperitoneal administration of cimetidine at a dose of 100 mg/kg or famotidine at a dose of 5 mg/kg 30 min after EtOH-HCl administration could not reduce the lesion indices in less than 24 h and suppressed the increase in mucosal hydroxyproline concentrations significantly compared with the control group. On the other hand, treatment with 10 mg/kg of E-3810, a proton pump inhibitor, had no effects on the lesion healing nor on the fluctuation of mucosal hydroxyproline concentrations. These facts suggest that H2-receptor antagonists might delay the healing of EtOH-HCl-induced gastric lesions through the suppression of collagen regeneration under the condition of exclusion of gastric acid secretion.
Suzuki
T
T
Second Department of Internal Medicine, Nagoya University School of Medicine, Japan.
Tsukamoto
Y
Y
Goto
H
H
Hase
S
S
Arisawa
T
T
Asai
J
J
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology*; D003094:Collagen / Q000378:metabolism; D000431:Ethanol; D015738:Famotidine / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000737:chemistry*; D006851:Hydrochloric Acid; D006909:Hydroxyproline / Q000032:analysis*; D008297:Male; D009853:Omeprazole / Q000031:analogs & derivatives; D064750:Rabeprazole; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology*
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D001562:Benzimidazoles; D064750:Rabeprazole; D000431:Ethanol; D015738:Famotidine; D002927:Cimetidine; D003094:Collagen; D000251:Adenosine Triphosphatases; D009853:Omeprazole; D006851:Hydrochloric Acid; D006909:Hydroxyproline