title: Quantitative color Doppler imaging in untreated and irradiated choroidal melanoma.
abstract: Histological data indicate the importance of tumor vascularization as a determinant of the biological behavior and the response to radiotherapy in choroidal melanoma. Duplex ultrasound and color Doppler imaging, the combination of B-mode ultrasound and pulse-waved Doppler analysis, were used to measure quantitatively neovascular blood flow in 31 patients with choroidal melanoma. Follow-up studies (20 patients) were performed to investigate the change of tumor blood flow in choroidal melanomas after radiotherapy. Blood flow was detected in 30 out of 31 melanomas (size 3.1-17.8 mm) within the tumor and at the tumor base with a mean peak systolic frequency of 1.0 kHz (range 0.3-2.7 kHz), a mean end diastolic frequency of 0.3 kHz (range 0.1-1.0 kHz), and a mean frequency of 0.7 kHz (range 0.2-1.3 kHz). Two and six months after 106Ru/106Rh beta-ray application, 19 patients showed a significant decrease in peak systolic frequency. This occurred with and in advance of the decrease in the tumor size. In one patient, a rising maximum systolic frequency after radiotherapy marked a recurrent tumor growth. Results indicate that the quantitative measurement of tumor blood flow by duplex ultrasound and color Doppler imaging may be a new diagnostic modality for monitoring the effectiveness of radiotherapy in choroidal melanoma.
authors.affiliation: University Eye Hospital, Munich, FRG.
authors.forename: P G
authors.initials: PG
authors.lastname: Wolff-Kormann
authors.forename: B A
authors.initials: BA
authors.lastname: Kormann
authors.forename: K G
authors.initials: KG
authors.lastname: Riedel
authors.forename: G C
authors.initials: GC
authors.lastname: Hasenfratz
authors.forename: F H
authors.initials: FH
authors.lastname: Stefani
authors.forename: F A
authors.initials: FA
authors.lastname: Spengel
authors.forename: O E
authors.initials: OE
authors.lastname: Lund
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity; D001918:Brachytherapy; D002830:Choroid Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000532:radiotherapy; D003116:Color; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008545:Melanoma / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000532:radiotherapy; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging; D011446:Prospective Studies; D011868:Radioisotopes; D012238:Rhodium; D012429:Ruthenium Radioisotopes; D014463:Ultrasonography
chemical_list: D011868:Radioisotopes; D012429:Ruthenium Radioisotopes; D012238:Rhodium