[Clinical pharmacokinetics of cis-diamminedichloroplatinum (DDP)].
We studied the pharmacokinetics of DDP in 9 cancer patients who received iv infusion of DDP (100-120 mg/m2). Platinum concentration was measured by high performance liquid chromatography (HPLC). Plasma clearance of platinum was biphasic. There was a short initial phase with a half life of 19.8 min and a long second phase with a half life of 41.13 hours. A small peak was noted in 5 hours after the end of DDP infusion in about 50% of patients. This suggested tissue reabsorption, release and entero-hepatic circulation. Plasma ultrafiltrable platinum concentration fell with a half life of 21 min. Nearly 75-96% of the platinum in the plasma was protein bound 24 minutes after DDP infusion. The urinary excretion of platinum was found to be 9.52-21.35% in 24 hours with 6.69-19.57% eliminated within the first three hours.
Zhang
M
M
Cancer Hospital, Chinese Academy of Medical Sciences, Beijing.
D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002945:Cisplatin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D002945:Cisplatin