Diaspirin cross-linked hemoglobin solution as a resuscitative fluid following severe hemorrhage in the rat.
The effect of diaspirin cross-linked hemoglobin (DCLHb) on mean arterial pressure (MAP) and heart rate (HR) was compared to Ringer's lactate (RL) and shed blood in a 70% lethal model of hemorrhage (35 cc/kg blood loss) in conscious rats. All animals resuscitated with DCLHb regardless of dose (17.5 and 35 cc/kg) and concentration (7% and 10% solution) exhibited complete restoration of MAP and HR which was maintained for at least 5 hrs. Hemodynamic responses in DCLHb-treated animals were not significantly different from 35 cc/kg blood-treated animals. In RL (105 cc/kg) treated animals the MAP was restored to 60-70% of baseline. 24 hr survival in animals resuscitated with fluids ranged between 88-100% and was not significantly different between treatment groups.
Malcolm
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D
Uniformed Services University of the Health Sciences, Bethesda, MD.
Kissinger
D
D
Garrioch
M
M
D000818:Animals; D001241:Aspirin / Q000031:analogs & derivatives; D001794:Blood Pressure; D001802:Blood Substitutes / Q000302:isolation & purification / Q000627:therapeutic use*; D001803:Blood Transfusion; D003432:Cross-Linking Reagents; D005069:Evaluation Studies as Topic; D006339:Heart Rate; D006454:Hemoglobins / Q000302:isolation & purification / Q000627:therapeutic use*; D006470:Hemorrhage / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012151:Resuscitation
D001802:Blood Substitutes; D003432:Cross-Linking Reagents; D006454:Hemoglobins; C030830:succinyldisalicylic acid; D001241:Aspirin