title: 1 beta-hydroxylated bile acids in the urine of healthy neonates.
abstract: In order to clarify the metabolism of bile acids in neonates, 1 beta-hydroxylated bile acids in the urine of healthy newborns were examined by gas chromatography-mass spectrometry. The results showed that the percentage of total 1 beta-hydroxylated bile acids, 3 beta, 12 alpha-dihydroxy-5-cholenoic acid and hyocholic acid in neonates was significantly higher than in older children. The ratio of 1 beta-hydroxylated bile acids to their comparable primary bile acids was also higher in neonates than in older children. These results suggest that 1 beta- and 6 alpha-hydroxylation of bile acids are the predominant pathways of bile acid metabolism in neonates.
authors.affiliation: Department of Pediatrics, Koshigaya Municipal Hospital, Saitama, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Obinata
authors.forename: H
authors.initials: H
authors.lastname: Nittono
authors.forename: K
authors.initials: K
authors.lastname: Yabuta
authors.forename: R
authors.initials: R
authors.lastname: Mahara
authors.forename: M
authors.initials: M
authors.lastname: Tohma
mesh_terms: D001647:Bile Acids and Salts / Q000378:metabolism / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D006900:Hydroxylation; D007223:Infant; D007231:Infant, Newborn / Q000652:urine*
chemical_list: D001647:Bile Acids and Salts