title: Intravenous catheterisation of foetus and mare in late pregnancy: management and respiratory, circulatory and metabolic effects.
abstract: The uterine and umbilical vessels of 12 pregnant ponies were catheterised to study foetal metabolism. The effects of this procedure on maternal and foetal cardiovascular, respiratory, metabolic and adrenocortical activity were monitored during and after surgery. Premedication with acepromazine-butorphanol-detomidine was followed by induction of anaesthesia with detomidine and ketamine and maintenance, using mechanical ventilation, with halothane in oxygen and nitrous oxide. Mean maternal arterial blood pressure was greater than 70 mmHg during anaesthesia and arterial oxygen tension remained over 100 mmHg. The foetuses were adequately oxygenated but were hypercapnic and lactic acidaemic. Most maternal and foetal blood gases and metabolites had returned to normal by 24 h, although foetal plasma lactate fell more slowly. The maternal adrenocortical discharge was less severe than reported previously and plasma cortisol had fallen to basal levels by 48 h after surgery. Foetal plasma cortisol remained low and did not change during or after surgery. Arterio-venous metabolite and gas tension differences across the uterine and umbilical circulations were slightly greater at operation than in the recovery period, suggesting that uteroplacental perfusion may have been impaired during surgery. Post-operative recovery of the mare and foetus was satisfactory and subsequent problems associated with the foetal catheters were not related to the anaesthesia or surgery.
authors.affiliation: Animal Health Trust, Newmarket, Suffolk, UK.
authors.forename: P M
authors.initials: PM
authors.lastname: Taylor
authors.forename: M
authors.initials: M
authors.lastname: Silver
authors.forename: A L
authors.initials: AL
authors.lastname: Fowden
mesh_terms: D000136:Acid-Base Equilibrium; D000768:Anesthesia, General / Q000662:veterinary*; D000818:Animals; D001784:Blood Gas Analysis / Q000662:veterinary; D001794:Blood Pressure; D002404:Catheterization / Q000662:veterinary*; D015237:Dinoprost / Q000031:analogs & derivatives / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005333:Fetus / Q000502:physiology*; D006736:Horses / Q000502:physiology / Q000601:surgery*; D006854:Hydrocortisone / Q000097:blood; D011182:Postoperative Care / Q000662:veterinary; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D012119:Respiration; D014469:Umbilical Arteries; D014471:Umbilical Veins; D014599:Uterus / Q000098:blood supply
chemical_list: C008228:15-keto-13,14-dihydroprostaglandin F2alpha; D015237:Dinoprost; D006854:Hydrocortisone