title: An increased ability to generate hydrogen peroxide in certain polymorphonuclear leukocytes in neonates.
abstract: We performed a quantitative assay of the hydrogen peroxide generation in polymorphonuclear leukocytes using single cell analysis by flow cytometry. The study population included premature neonates (n = 10), term neonates (n = 28) and healthy adults (n = 29). The ability to generate hydrogen peroxide in neonatal polymorphonuclear leukocytes was totally reduced compared with adults, however, some polymorphonuclear leukocytes in neonates demonstrated highly accentuated hydrogen peroxide generation.
authors.affiliation: Department of Pediatrics, Asahikawa Medical College, Japan.
authors.forename: D
authors.initials: D
authors.lastname: Ueda
authors.forename: Y
authors.initials: Y
authors.lastname: Sakata
authors.forename: K
authors.initials: K
authors.lastname: Sasaki
authors.forename: H
authors.initials: H
authors.lastname: Azuma
mesh_terms: D000328:Adult; D005434:Flow Cytometry; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood*; D007231:Infant, Newborn / Q000097:blood*; D007234:Infant, Premature / Q000097:blood; D009504:Neutrophils / Q000378:metabolism*
chemical_list: D006861:Hydrogen Peroxide