title: Quinolinehydrazones as inhibitors of retroviral reverse transcriptase.
abstract: The inhibitory activity of a series of 2- and 4-quinolinehydrazones on retroviral reverse transcriptase has been studied on enzymes from M-MuLV, RAV-2, and on a crude lysate of HIV-1, assuming the first two enzymes as potential models of the third. The highest activity is mainly found in lipophilic, water soluble 4-quinolinehydrazones. The inhibitory activity of these compounds decreases in changing from the M-MuLV to the RAV-2, and HIV-1 enzymes, in this order.
authors.affiliation: Instituto di Strutturistica Chimica G. Giacomello, C.N.R., Roma.
authors.forename: C
authors.initials: C
authors.lastname: Bartolucci
authors.forename: L
authors.initials: L
authors.lastname: Cellai
authors.forename: P
authors.initials: P
authors.lastname: Di Filippo
authors.forename: V
authors.initials: V
authors.lastname: Brizzi
authors.forename: C
authors.initials: C
authors.lastname: Pellerano
authors.forename: L
authors.initials: L
authors.lastname: Savini
authors.forename: A
authors.initials: A
authors.lastname: Benedetto
authors.forename: G
authors.initials: G
authors.lastname: Elia
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D012190:Retroviridae / Q000201:enzymology*; D018894:Reverse Transcriptase Inhibitors
chemical_list: D006835:Hydrazones; D011804:Quinolines; D018894:Reverse Transcriptase Inhibitors