title: Brain neurite-stimulating protein promotes formation of mechanosensory endings in sensory neuron.
abstract: In the present study we have shown that in the organotypic culture of dorsal root ganglia (DRG) of 10-11 day-old chick embryos, the neurite-stimulating protein (NSP) from bovine brain promotes the development of branching mechanosensory endings. The light and electron microscopic observation revealed that the morphological features of these sensory endings are similar to those in vivo. A mechanical stimulation of these endings elicited bursts of impulses in the sensory neurons.
authors.affiliation: Pavlov Institute of Physiology, Russian Academy of Sciences, St. Peterburg.
authors.forename: G N
authors.initials: GN
authors.lastname: Akoev
authors.forename: O S
authors.initials: OS
authors.lastname: Sotnikov
authors.forename: N I
authors.initials: NI
authors.lastname: Chalisova
authors.forename: V G
authors.initials: VG
authors.lastname: Lukashin
authors.forename: S S
authors.initials: SS
authors.lastname: Sergeeva
authors.forename: V V
authors.initials: VV
authors.lastname: Vshivoeva
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D002417:Cattle; D002642:Chick Embryo; D005727:Ganglia, Spinal / Q000502:physiology* / Q000648:ultrastructure; D008564:Membrane Potentials; D009411:Nerve Endings / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D009414:Nerve Growth Factors; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D009924:Organ Culture Techniques; D010455:Peptides / Q000494:pharmacology*; D010812:Physical Stimulation
chemical_list: D009414:Nerve Growth Factors; D010455:Peptides; C047805:neurite-inducing factor