title: Blood-CSF barrier permeability and central nervous system immunoglobulin G in schizophrenia.
abstract: The ratio of albumin in cerebrospinal fluid (CSF) to serum may serve as an index of the integrity of the blood-CSF barrier, with increases in this ratio indicating increased permeability. The ratio of immunoglobulin G (IgG) in CSF to serum (divided by the albumin ratio to correct for variance in blood-CSF permeability) represents an index of the endogenous production of IgG in the central nervous system (CNS), with increases reflecting a possible infectious and/or autoimmune process stimulating central IgG synthesis. We analyzed simultaneously collected CSF and serum samples from 46 schizophrenic subjects, 8 of whom were studied both on and off neuroleptic treatment, and samples from 20 normal controls. The data indicated increases in CSF/serum albumin ratios or CSF/serum IgG indices in 22% and 20%, respectively, of the schizophrenic patients. Only 3 patients showed elevations in both indices. Comparison of values on and off neuroleptics indicated no significant effect of neuroleptics on these indices.
authors.affiliation: Division of Clinical Research, National Institute of Mental Health, Rockville, Maryland.
authors.forename: D G
authors.initials: DG
authors.lastname: Kirch
authors.forename: R C
authors.initials: RC
authors.lastname: Alexander
authors.forename: R L
authors.initials: RL
authors.lastname: Suddath
authors.forename: N M
authors.initials: NM
authors.lastname: Papadopoulos
authors.forename: C A
authors.initials: CA
authors.lastname: Kaufmann
authors.forename: D G
authors.initials: DG
authors.lastname: Daniel
authors.forename: R J
authors.initials: RJ
authors.lastname: Wyatt
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000418:Albumins / Q000134:cerebrospinal fluid*; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000276:immunology / Q000502:physiology*; D002490:Central Nervous System / Q000276:immunology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology*; D014149:Tranquilizing Agents / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000418:Albumins; D007074:Immunoglobulin G; D014149:Tranquilizing Agents