title: Polymeric pseudolatices bearing pilocarpine for controlled ocular delivery.
abstract: The pseudolatex-based ocular formulations of pilocarpine were prepared using different combinations of Eudragit RS 100 and polyvinyl pyrrolidone for prolonged and controlled release of the drug. The designed system was essentially based on polymeric pseudolatex dispersion. The process variables that effect the latex particle size, drug loading and release profiles of drug were studied. Preparations were evaluated for their in vitro performance with regard to release profile and diffusion co-efficient. The designed system exhibited linear relationship between cumulative drug release (Q) and square root of time (t0.5). The products selected on the basis of in vitro characterization were studied for in vivo performance evaluation. It was observed that the preparations exhibited in vivo prolonged therapeutic efficacy. Thus polymer based pseudolatices hold promise for controlled pilocarpine ocular delivery.
authors.affiliation: Pharmaceutics Laboratories, Department of Pharmaceutical Sciences, Sagar, India.
authors.forename: S P
authors.initials: SP
authors.lastname: Vyas
authors.forename: S
authors.initials: S
authors.lastname: Ramchandraiah
authors.forename: C P
authors.initials: CP
authors.lastname: Jain
authors.forename: S K
authors.initials: SK
authors.lastname: Jain
mesh_terms: D000042:Absorption; D000180:Acrylic Resins; D000818:Animals; D002214:Capsules; D003692:Delayed-Action Preparations; D004355:Drug Stability; D008297:Male; D008916:Miotics / Q000008:administration & dosage / Q000493:pharmacokinetics; D009883:Ophthalmic Solutions; D010862:Pilocarpine / Q000008:administration & dosage* / Q000493:pharmacokinetics; D011205:Povidone; D011680:Pupil / Q000187:drug effects; D011817:Rabbits; D014783:Viscosity
chemical_list: D000180:Acrylic Resins; D002214:Capsules; D003692:Delayed-Action Preparations; D008916:Miotics; D009883:Ophthalmic Solutions; D010862:Pilocarpine; C050528:Eudragit RS; D011205:Povidone