Experimental atrophic rhinitis in 2 and 4 month old pigs infected sequentially with Bordetella bronchiseptica and toxigenic type D Pasteurella multocida.
Experimental infections with Bordetella bronchiseptica and/or toxigenic type D Pasteurella multocida were studied in 2- and 4-month-old primary specific-pathogen-free pigs. None of the 2-month-old pigs inoculated with B. bronchiseptica or P. multocida alone developed turbinate atrophy. All the pigs inoculated with B. bronchiseptica (10(7) CFU/head) and P. multocida (10(9) CFU/head for 5 consecutive days) together, however, developed clinical and post-mortem signs of atrophic rhinitis (AR) similar to the naturally occurring disease. Slight to severe turbinate atrophy was observed in the 4-month-old pigs inoculated with B. bronchiseptica and P. multocida (at the same concentration as above) at necropsy.
Sakano
T
T
Zen-noh Institute of Animal Health, Sakura, Japan.
Okada
M
M
Taneda
A
A
Ono
M
M
Sato
S
S
D000818:Animals; D001284:Atrophy; D001885:Bordetella Infections / Q000150:complications / Q000662:veterinary*; D016950:Bordetella bronchiseptica / Q000502:physiology; D010326:Pasteurella Infections / Q000150:complications / Q000662:veterinary*; D016979:Pasteurella multocida / Q000502:physiology; D012222:Rhinitis, Atrophic / Q000382:microbiology / Q000662:veterinary*; D013047:Specific Pathogen-Free Organisms; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology*; D014420:Turbinates / Q000473:pathology