Response of pulpal blood flow to intra-arterial infusion of endothelin.
Laser Doppler flowmetry was used to determine the effect of the vasoconstrictor endothelin 1 (ET-1) on the pulpal blood flow of intact dogs' teeth during mandibular arterial infusion. ET-1 produced a profound decrease in pulpal blood flow of a relatively long duration at lower doses than similar infusions of norepinephrine. The decrease in pulpal blood flow in response to ET-1 was partially attenuated by the calcium channel blocker nifedipine. These findings demonstrate the presence of receptors for ET-1 in the microvasculature of the dental pulp and suggests that ET-1 may function in the local control of the pulpal microcirculation.
Gilbert
T M
TM
Pashley
D H
DH
Anderson
R W
RW
D000818:Animals; D003782:Dental Pulp / Q000098:blood supply* / Q000187:drug effects*; D004285:Dogs; D016232:Endothelins / Q000494:pharmacology*; D017078:Laser-Doppler Flowmetry; D008833:Microcirculation / Q000187:drug effects*; D012039:Regional Blood Flow / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000494:pharmacology
D016232:Endothelins; D014662:Vasoconstrictor Agents