Neurochemical changes in the rat brain after intraventricular administration of tryptamine-4,5-dione.
Tryptamine-4,5-dione (4,5-DKT) a neurotoxic derivative of serotonin (5-HT), was injected into the lateral ventricle of the rat in order to evaluate its biochemical effects. The levels of 8 substances in the hippocampus, striatum and prefrontal cortex were examined 3, 7 and 14 days after treatment with 4,5-DKT. 5-Hydroxytryptamine and 5-hydroxyindoleacetic acid (5-HIAA) levels were decreased in all three regions by days 7 and 14, respectively. Tryptamine-4,5-dione had no significant effect on dopaminergic or adrenergic systems or on the levels of L-tryptophan and L-tyrosine, in any of the three areas of brain examined. Reduced activity of tryptophan hydroxylase in the cortex was observed 14 days after administration of 4,5-DKT. However, administration of 4,5-DKT did not alter the binding of [3H]paroxetine, a specific antagonist of the uptake of 5-HT, to nerve terminals. These results indicate that 4,5-DKT produced depletion of 5-HT without eliminating serotoninergic nerve terminals.
Chen
J C
JC
Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, MA 02118.
Schnepper
P W
PW
To
A
A
Volicer
L
L
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D004563:Electrochemistry; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D066298:In Vitro Techniques; D045563:Indolequinones; D007276:Injections, Intraventricular; D008297:Male; D008566:Membranes / Q000187:drug effects / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism; D017374:Paroxetine; D010880:Piperidines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism; D012702:Serotonin Antagonists / Q000494:pharmacology; D014363:Tryptamines / Q000008:administration & dosage / Q000494:pharmacology*; D014365:Tryptophan Hydroxylase / Q000378:metabolism
D045563:Indolequinones; D018377:Neurotransmitter Agents; D010880:Piperidines; D012702:Serotonin Antagonists; D014363:Tryptamines; C060213:tryptamine-4,5-dione; D012701:Serotonin; D017374:Paroxetine; D006897:Hydroxyindoleacetic Acid; D014365:Tryptophan Hydroxylase