title: CA-125 as a maternal serum marker for Down's syndrome in the first and second trimesters.
abstract: CA-125, alpha-fetoprotein (AFP), and human chorionic gonadotropin (HCG) were determined in maternal serum in the first trimester from 14 women with a Down's syndrome fetus and 61 women with a healthy fetus. In the second trimester, 15 and 60 serum samples were determined from women with a Down's syndrome and a healthy fetus respectively. In both trimesters, maternal serum CA-125 was found to be elevated in Down's syndrome pregnancies compared with controls. Using discrimination functions, our preliminary results indicate that CA-125 is a better marker than AFP and HCG respectively for a Down's syndrome fetus in the first trimester and improves the detection rate in the second trimester.
authors.affiliation: Department of Gynaecology and Obstetrics, Rigshospitalet, University of Copenhagen, Denmark.
authors.forename: C K
authors.initials: CK
authors.lastname: Høgdall
authors.forename: E V
authors.initials: EV
authors.lastname: Høgdall
authors.forename: J
authors.initials: J
authors.lastname: Arends
authors.forename: B
authors.initials: B
authors.lastname: Nørgaard-Pedersen
authors.forename: S
authors.initials: S
authors.lastname: Smidt-Jensen
authors.forename: S O
authors.initials: SO
authors.lastname: Larsen
mesh_terms: D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D006063:Chorionic Gonadotropin / Q000097:blood; D004314:Down Syndrome / Q000175:diagnosis*; D005260:Female; D006801:Humans; D011247:Pregnancy / Q000097:blood*; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins