title: Cytotoxicity of a transferrin-adriamycin conjugate to anthracycline-resistant cells.
abstract: Conjugates of adriamycin coupled to transferrin by glutaraldehyde are cytotoxic to human promyelocytic (HL-60) and erythroleukemic (K562) cells. Growth inhibition of adriamycin-sensitive cells, as evaluated by thymidine incorporation and the MTT-assay, was higher for conjugates than for free adriamycin. The cytotoxicity toward adriamycin-resistant K562 and HL-60 cells was 3-fold and more than 10-fold higher, respectively, for the transferrin-adriamycin conjugate than for the free drug. The effect of the conjugate was dependent on its adriamycin content, i.e., on its conjugation number.
authors.affiliation: Institut für Medizinische Chemie, University of Vienna, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Fritzer
authors.forename: K
authors.initials: K
authors.lastname: Barabas
authors.forename: V
authors.initials: V
authors.lastname: Szüts
authors.forename: A
authors.initials: A
authors.lastname: Berczi
authors.forename: T
authors.initials: T
authors.lastname: Szekeres
authors.forename: W P
authors.initials: WP
authors.lastname: Faulk
authors.forename: H
authors.initials: H
authors.lastname: Goldenberg
mesh_terms: D004317:Doxorubicin / Q000008:administration & dosage* / Q000494:pharmacology; D004351:Drug Resistance; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000473:pathology; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology; D014168:Transferrin / Q000008:administration & dosage* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D014168:Transferrin; D004317:Doxorubicin