Parathyroid hormone fragment 1-34 and anti-inflammatory effect.
We have studied the possible activity of the rat parathyroid hormone fragment 1-34, peripherally or centrally injected, on the vascular permeability induced by local administration of croton oil. Our study considered also the possible interference of parathyroid hormone fragment 1-34 on the release of histamine by mast cells and on the content of histamine in paw tissue. Parathyroid hormone fragment 1-34 significantly reduced the increase in vascular permeability produced in mice by local croton oil injection, as well as the serotonin-induced paw edema in the rat. These effects of parathyroid hormone fragment 1-34 were present only after peripheral administration. At the dose of 3.3 micrograms/kg, it decreased the histamine content in paw tissue. Peripheral administration of a calcium antagonist, such as nimodipine, at the dose of 50 micrograms/kg, or a metal-chelating agent, such as ethylene-diaminetetraacetic acid, at the dose of 10 micrograms/kg, antagonized the anti-inflammatory effect of parathyroid hormone fragment 1-34. Moreover, at 10-100 microliters/ml it significantly decreased the histamine release by mast cells.
Clementi
G
G
Institute of Pharmacology, University of Catania School of Medicine, Italy.
Caruso
A
A
Cutuli
V
V
Prato
A
A
Fiore
C E
CE
Amico-Roxas
M
M
D000707:Anaphylaxis / Q000139:chemically induced / Q000517:prevention & control; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D003436:Croton Oil; D003877:Dermatitis, Contact / Q000517:prevention & control; D003911:Dextrans; D004487:Edema / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D006636:Histamine Release / Q000187:drug effects; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D010281:Parathyroid Hormone / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin; D019379:Teriparatide
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003911:Dextrans; D010281:Parathyroid Hormone; D010446:Peptide Fragments; D019379:Teriparatide; D012701:Serotonin; D003436:Croton Oil