Artificial blood and extracorporeal circulation (ECC).
To investigate a possible clinical use in ECC of artificial blood (AB) by means of a stroma free, polymerized and pyridoxylated hemoglobin a feasibility study was performed. Group I (5 calves) served as control. Group II (5 calves) received 2000 ml of a mixture of one part AB and one part Ringer's solution, group III (5 calves) 2000 ml of AB as priming solution. Blood samples were taken preoperatively, at 6 h, 24 h and then weekly up to 1 month. All animals survived and could be weaned from the ventilator immediately after the operation. Total hemoglobin was 10.6 before and 9.5 g/dl 12 h after the operation in mean in the group I and 11.5 and 11.9 for group II and III. Aortic mean pressure was increased in group II/III from preoperatively 105/95 mmHg to 124/135 mmHg after the end of cardio pulmonary bypass (CPB). The pulmonary vascular resistance increased in group II/III from 92/52 to 214/264 dyn*s*cm-5 in mean. This could not be observed in group I. Pulmonary resistance correlated with the concentration of free plasma hemoglobin.
Schistek
R
R
Department f. Cardiac Surgery, LKA Salzburg, Vienna.
Pohla
G
G
Samhaber
E
E
Unger
F
F
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001802:Blood Substitutes / Q000627:therapeutic use*; D002315:Cardiopulmonary Bypass; D002417:Cattle; D005069:Evaluation Studies as Topic; D005112:Extracorporeal Circulation / Q000379:methods*; D005260:Female; D006454:Hemoglobins / Q000627:therapeutic use*; D011652:Pulmonary Circulation / Q000187:drug effects; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014655:Vascular Resistance / Q000187:drug effects
D001802:Blood Substitutes; D006454:Hemoglobins; C016484:hemoglobin, stroma free; C037158:polyhemoglobin; C030939:polyhemoglobin-pyridoxal-5-phosphate; D011732:Pyridoxal Phosphate