[Effects of pesticide fluometuron (cotoran) on template synthesis of RNA].
The experiments on the investigation of pesticide fluometuron (cotoran) influence on nuclease sensitivity and template activity of rat liver chromatin were carried out. Cotoran was found to bind specifically with non-histone proteins of chromatin. It was shown that this pesticide considerably decreases template activity of chromatin and its sensitivity to the action of nucleases. It suggests, that certain conformation changes occur in chromatin upon the action of cotoran.
Khamidov
D Kh
DKh
Mirakhmedov
A K
AK
Sagatova
G A
GA
Azimova
Sh S
ShS
D000818:Animals; D002843:Chromatin / Q000187:drug effects; D012321:DNA-Directed RNA Polymerases / Q000187:drug effects; D003851:Deoxyribonucleases / Q000187:drug effects; D006540:Herbicides / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008782:Methylurea Compounds / Q000633:toxicity*; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D013698:Templates, Genetic
D002843:Chromatin; D006540:Herbicides; D008782:Methylurea Compounds; C005015:fluometuron; D012313:RNA; D012321:DNA-Directed RNA Polymerases; D003851:Deoxyribonucleases