title: Young CA1 pyramidal cells of rats, but not dentate gyrus granule cells, express a delayed inward rectifying current with properties of IQ.
abstract: In hippocampal CA1 pyramidal cells (CA1PC) and dentate gyrus granule cells (DGGC) we compared the expression of currents which could cause differences in discharge behaviour. Negative current injections cause a uniform hyperpolarization in DGGC whereas in CA1PC the initial hyperpolarization is followed by a repolarization towards resting membrane potential. The underlying inward current can be classified as IQ. It is sensitive to CsCl, activated at -80 mV, and it has a mean amplitude of -109.8 pA and a mean activation time constant of 187 ms with voltage jumps from -40 to -120 mV. We conclude that some of the differences in response properties of DGGC and CA1PC upon repetitive stimulation can be attributed to differences in the expression of IQ.
authors.affiliation: Institut für Neurophysiologie, Universität zu Köln, F.R.G.
authors.forename: J
authors.initials: J
authors.lastname: Stabel
authors.forename: E
authors.initials: E
authors.lastname: Ficker
authors.forename: U
authors.initials: U
authors.lastname: Heinemann
mesh_terms: D000818:Animals; D002586:Cesium / Q000494:pharmacology; D004594:Electrophysiology; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology*; D008564:Membrane Potentials / Q000502:physiology; D011712:Pyramidal Tracts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007473:Ion Channels; D002586:Cesium