Autoreactive cytotoxic cells in rabbits after prolonged immunostimulation.
Rabbits immunized for 6 months with different amounts of sterile human serum showed weight loss and a decrease in leukocytes. The lymphocyte population reacting to ConA contained autoreactive cells capable of causing 51Cr release from labeled cells from a culture consisting of splenic and peripheral lymphocytic cells from the same animal.
Galdiero
F
F
Istituto di Microbiologia, I Facoltà di Medicina e Chirurgia, Università di Napoli, Italy.
Romano Carratelli
C
C
Nuzzo
I
I
Bentivoglio
C
C
Galdiero
M P
MP
D000818:Animals; D006801:Humans; D007114:Immunization; D007273:Injections, Intramuscular; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D011817:Rabbits / Q000276:immunology*; D013045:Species Specificity; D013154:Spleen / Q000276:immunology / Q000473:pathology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*