title: Variability of serum levels for three oral 8-methoxypsoralen brands.
abstract: We conducted a pilot study to investigate the serum level patterns of 3 commercial and internationally introduced 8-methoxypsoralen (8-MOP) preparations in 9 patients for their bioequivalence and registered the interindividual variability of serum levels over 8 h after intake of 30 mg 8-MOP equivalent doses. On average, the highest serum levels (Cmax 120.1, range 235-61 ng.ml-1) were reached as early as 0.5-1 h after ingestion of Geroxalen soft gelatin capsules, whereas lower serum levels were seen after intake of the Oxsoralen hard gelatin capsules (Cmax 82.3, range 154-47 ng.ml-1) and the Mopsoralen tablets (Cmax 81.3, range 172-26 ng.ml-1). The importance of 8-MOP serum level determination for better and efficient PUVA therapy is discussed.
authors.affiliation: Department of Dermatology, University of Leipzig, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Walther
authors.forename: B
authors.initials: B
authors.lastname: Quednow
authors.forename: U F
authors.initials: UF
authors.lastname: Haustein
authors.forename: F P
authors.initials: FP
authors.lastname: Meyer
mesh_terms: D000328:Adult; D001835:Body Weight; D006801:Humans; D008730:Methoxsalen / Q000493:pharmacokinetics*; D010865:Pilot Projects
chemical_list: D008730:Methoxsalen