title: Highly conserved epitope domain in major core protein p24 is structurally similar among human, simian and feline immunodeficiency viruses.
abstract: Linear B cell epitopes were mapped on the major core protein p24 of human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus (SIVAGM) and feline immunodeficiency virus (FIV) using a fusion protein-based method and murine monoclonal antibodies reactive against the p24 antigens expressed on the surface of HIV-1- and FIV-infected cells. The results suggest that the sites identified here are encoded at similar positions in the three virus genomes and consist of highly conserved epitopes, which could exhibit immunodominance.
authors.affiliation: Central Research Laboratories, Ajinomoto Co. Inc., Japan.
authors.forename: K
authors.initials: K
authors.lastname: Matsuo
authors.forename: Y
authors.initials: Y
authors.lastname: Nishino
authors.forename: T
authors.initials: T
authors.lastname: Kimura
authors.forename: R
authors.initials: R
authors.lastname: Yamaguchi
authors.forename: A
authors.initials: A
authors.lastname: Yamazaki
authors.forename: T
authors.initials: T
authors.lastname: Mikami
authors.forename: K
authors.initials: K
authors.lastname: Ikuta
mesh_terms: D000595:Amino Acid Sequence; D003001:Cloning, Molecular; D000939:Epitopes / Q000235:genetics; D006678:HIV / Q000235:genetics / Q000276:immunology*; D016655:HIV Core Protein p24 / Q000235:genetics / Q000276:immunology; D016089:Immunodeficiency Virus, Feline / Q000235:genetics / Q000276:immunology*; D008969:Molecular Sequence Data; D011993:Recombinant Fusion Proteins / Q000096:biosynthesis; D017386:Sequence Homology, Amino Acid; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000276:immunology*; D014758:Viral Core Proteins / Q000235:genetics / Q000276:immunology*
chemical_list: D000939:Epitopes; D016655:HIV Core Protein p24; D011993:Recombinant Fusion Proteins; D014758:Viral Core Proteins