title: Fibrous mastocytoma in a patient with generalized cutaneous mastocytosis.
abstract: A 57-year-old woman with cutaneous mastocytosis of 23 years duration developed a hyperpigmented abdominal plaque composed of confluent indurated papules that enlarged for a period of 1 year to 12 x 8 cm. Biopsy showed dermal infiltration by closely packed spindle-shaped mast cells, fibroblasts, collagen, and scattered lymphocytes, predominantly T-suppressor cells. Electron microscopy showed close contact between mast cells, fibroblasts, and lymphocytes. Piecemeal mast cell degranulation and extrusion of mast cell granules was seen, with rare mast cell granules in fibroblasts, and collagen fibers in peripheral and perinuclear endoplasmic reticulum of mast cells. the term Fibrous mastocytoma is suggested for this tumor-like dermal fibrosis, possibly induced by lymphokines.
authors.affiliation: Department of Dermatology, School of Medicine, University of Maryland, Baltimore.
authors.forename: C
authors.initials: C
authors.lastname: Wood
authors.forename: B
authors.initials: B
authors.lastname: Sina
authors.forename: C G
authors.initials: CG
authors.lastname: Webster
authors.forename: D
authors.initials: D
authors.lastname: Kurgansky
authors.forename: C B
authors.initials: CB
authors.lastname: Drachenberg
authors.forename: E A
authors.initials: EA
authors.lastname: Reedy
mesh_terms: D001706:Biopsy; D003094:Collagen / Q000648:ultrastructure; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D006801:Humans; D008407:Mast Cells / Q000473:pathology; D012515:Mast-Cell Sarcoma / Q000150:complications* / Q000473:pathology; D008415:Mastocytosis / Q000150:complications* / Q000473:pathology; D008854:Microscopy, Electron; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology; D013194:Staining and Labeling; D013601:T-Lymphocytes / Q000473:pathology
chemical_list: D003094:Collagen