title: The small non-structural protein NS2 of the autonomous parvovirus minute virus of mice is required for virus growth in murine cells.
abstract: Mutants of the autonomous parvovirus minute virus of mice (MVM) strains MVM(p) and MVM(i) that either fail to produce or produce a truncated NS2 protein, were deficient in the production of infectious virus and attained lower levels of viral DNA synthesis than wild-type virus following infection of a series of normal and transformed murine cell lines. Mutant virus growth and the levels of DNA replication were similar to those of wild-type virus in the rat, hamster and human lines tested. These results suggest that the requirement of NS2 for the growth of MVM is murine species-specific.
authors.affiliation: Department of Molecular Microbiology and Immunology, University of Missouri-Columbia School of Medicine 65212.
authors.forename: J E
authors.initials: JE
authors.lastname: Cater
authors.forename: D J
authors.initials: DJ
authors.lastname: Pintel
mesh_terms: D000818:Animals; D002213:Capsid / Q000235:genetics / Q000502:physiology*; D002460:Cell Line; D004261:DNA Replication; D051379:Mice; D008915:Minute Virus of Mice / Q000254:growth & development*; D009154:Mutation; D014758:Viral Core Proteins / Q000235:genetics / Q000502:physiology*; D017361:Viral Nonstructural Proteins; D014779:Virus Replication
chemical_list: D014758:Viral Core Proteins; D017361:Viral Nonstructural Proteins