Endothelial cell interactions with granulocytes: tethering and signaling molecules.
The adhesion of granulocytes to endothelial cells requires regulated expression of molecules on both the endothelial cell and the granulocyte. These pro-adhesive molecules have diverse structures and mechanisms of expression, and act either to tether the two cells together or as signals that induce activation-dependent adhesion events. Combinations of tethering and signaling molecules regulate endothelial-cell-granulocyte interactions at the endothelial surface.
Zimmerman
G A
GA
Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City 84112.
Prescott
S M
SM
McIntyre
T M
TM
D015815:Cell Adhesion Molecules / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology*; D006801:Humans; D016023:Integrins / Q000502:physiology; D009504:Neutrophils / Q000502:physiology*; D019007:P-Selectin; D010972:Platelet Activating Factor / Q000502:physiology; D010980:Platelet Membrane Glycoproteins / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D015815:Cell Adhesion Molecules; D016023:Integrins; D019007:P-Selectin; D010972:Platelet Activating Factor; D010980:Platelet Membrane Glycoproteins