Sexual differentiation and the germ cell in sex reversed gonads after aromatase inhibition in the chicken embryo.
Chicken embryos were treated on day three of incubation with a steroidal or a non-steroidal aromatase inhibitor (1-methyl-androstendion, CGS 16949 A). Complete sex reversal of ovaries into testes or intermediate stages of sex reversal resulted from the inhibitory effect on oestradiol formation during gonadal development before and during sexual differentiation. Germ cell differentiation shifted from the female to the male pattern depending on the local advance of sex reversal.
Wartenberg
H
H
Department of Anatomy, University of Bonn, Germany.
Lenz
E
E
Schweikert
H U
HU
D000818:Animals; D047072:Aromatase Inhibitors; D002642:Chick Embryo; D012734:Disorders of Sex Development; D017316:Fadrozole; D005260:Female; D007093:Imidazoles / Q000494:pharmacology*; D007621:Karyotyping; D008297:Male; D009570:Nitriles / Q000494:pharmacology*; D010053:Ovary / Q000166:cytology; D012733:Sex Differentiation / Q000187:drug effects*; D012744:Sex Ratio; D013737:Testis / Q000166:cytology / Q000187:drug effects* / Q000196:embryology
D047072:Aromatase Inhibitors; D007093:Imidazoles; D009570:Nitriles; D017316:Fadrozole