title: Mode of delivery, plasma catecholamines and Doppler-derived cardiac output in healthy term newborn infants.
abstract: Umbilical cord arterial and venous concentrations of epinephrine, norepinephrine and the catecholamine metabolites 3,4-dihydroxyphenylglycol and 3,4-dihydroxyphenylacetic acid were determined in 41 healthy newborn infants delivered vaginally, vaginally with epidural analgesia, by cesarean section under general anesthesia or by cesarean section under epidural anesthesia. Doppler-derived cardiac output and arterial blood pressure were repeatedly measured during the first 48 h of life. There were fairly small differences in umbilical arterial and venous plasma concentrations of epinephrine and norepinephrine between the groups, with the highest levels of norepinephrine in infants delivered vaginally without analgesia (about 10 times as high as in the cesarean, general anesthetized group). No significant differences were found in the metabolite concentrations. Doppler-derived cardiac output and heart rate decreased in all groups during the study period and, in spite of increased catecholamine levels in the vaginally delivered infants, the differences between the groups were marginal. Healthy term infants with no signs of asphyxia were well prepared for a normal hemodynamic adaptation irrespective of mode of delivery or mode of obstetric anesthesia/analgesia.
authors.affiliation: Department of Pediatrics, University of Turku, Finland.
authors.forename: H
authors.initials: H
authors.lastname: Hirsimäki
authors.forename: P
authors.initials: P
authors.lastname: Kero
authors.forename: H
authors.initials: H
authors.lastname: Ekblad
authors.forename: M
authors.initials: M
authors.lastname: Scheinin
authors.forename: M
authors.initials: M
authors.lastname: Saraste
authors.forename: R
authors.initials: R
authors.lastname: Erkkola
mesh_terms: D015360:Analgesia, Epidural; D000767:Anesthesia, Epidural; D000768:Anesthesia, General; D001794:Blood Pressure / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology*; D002395:Catecholamines / Q000097:blood*; D036861:Delivery, Obstetric / Q000379:methods*; D004837:Epinephrine / Q000097:blood; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn / Q000097:blood* / Q000502:physiology*; D007773:Lactates / Q000097:blood; D008734:Methoxyhydroxyphenylglycol / Q000031:analogs & derivatives / Q000097:blood; D009638:Norepinephrine / Q000097:blood; D011247:Pregnancy; D014465:Ultrasonics
chemical_list: D002395:Catecholamines; D007773:Lactates; C035055:3,4-dihydroxyphenyllactic acid; D008734:Methoxyhydroxyphenylglycol; C010117:3,4-dihydroxyphenylglycol; D009638:Norepinephrine; D004837:Epinephrine