[Intrauterine device-induced menorrhagia and endometrial content of prostacyclins].
The endometrial concentration of 6-keto-PGF1 alpha and TXB2 were measured by RIA in women with Tcu-IUD induced menorrhagia (MBL greater than 80 ml) and in levonorgestrel-IUD users with oligomenorrhea or amenorrhea. Non-IUD users with normal menses (MBL less than 80 ml) were chosen as control. It was found that the Tcu-IUD group showed a significantly higher 6-keto-PGF1 alpha concentration than the other two groups (P less than 0.01). Conversely, the TXB2 concentration of levonorgestrel-IUD group was significantly higher than that of the other groups (P less than 0.05). As a result, the 6-keto-PGF1 alpha/TXB2 ratio was much higher in Tcu-IUD group (P less than 0.01). Our results indicated that the unbalance of PGI2/TXA2 ratio may be the direct cause of the IUD-induced menorrhagia.
Zhang
J Y
JY
Tongji Hospital of Tongji Medical University, Wuhan.
Luo
L L
LL
D015121:6-Ketoprostaglandin F1 alpha / Q000032:analysis; D000328:Adult; D004717:Endometrium / Q000737:chemistry*; D011464:Epoprostenol / Q000032:analysis*; D005260:Female; D006801:Humans; D007434:Intrauterine Devices / Q000009:adverse effects*; D007435:Intrauterine Devices, Copper / Q000009:adverse effects; D007436:Intrauterine Devices, Medicated / Q000009:adverse effects; D016912:Levonorgestrel; D008595:Menorrhagia / Q000209:etiology* / Q000378:metabolism; D009839:Oligomenorrhea / Q000209:etiology / Q000378:metabolism; D013929:Thromboxane B2 / Q000032:analysis
D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D016912:Levonorgestrel; D011464:Epoprostenol