[Pharmacokinetic studies of menogaril (TUT-7) with rats].
Menogaril (TUT-7) is a novel antitumor antibiotic belonging to anthracyclines. The pharmacokinetic parameters derived from plasma concentration-time profiles after repeated (for 14 days) or single oral administration of TUT-7 to rats were found to be not significantly different by either administration schedule. The rats with artificial liver dysfunction were obtained by subcutaneous application of carbon tetrachloride (CCl4, 1 ml/kg) for 3 days. After oral administration of TUT-7 to the rats with CCl4-induced liver toxicity (3 daily administrations of 1mg/kg, S.C.), the maximum plasma concentrations (Cmax) and AUC of both the unchanged drug and its metabolite N-Demethyl menogaril, were increased. Also over all elimination was slower in animals with liver dysfunction.
Ohashi
K
K
Division of Clinical Pharmacology Center, Nippon Medical School, Japan.
Hara
H
H
Takahashi
F
F
Aso
R
R
Akimoto
T
T
Nakama
K
K
D000284:Administration, Oral; D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D002252:Carbon Tetrachloride Poisoning / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury; D008107:Liver Diseases / Q000097:blood; D008297:Male; D017290:Menogaril; D009621:Nogalamycin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D051381:Rats
D000970:Antineoplastic Agents; D017290:Menogaril; D009621:Nogalamycin