title: [Laparoscopic surgery versus laparotomy. Comparative analysis of stress markers].
abstract: The place of laparoscopic surgery continues to increase in the field of surgery in our specialty. Although the advantages would seem to be obvious, it seemed to us interesting to quantify, if possible, the parameters of operative stress and compare laparoscopic surgery with conventional surgery. Markers studied are Prolactin, Cortisol, Adrenaline, Nor-Adrenaline, Dopamine and the Beta-Endorphins. The only marker that shows any difference in the two procedures in our study is Beta-Endorphin which is significantly less raised in laparoscopic surgery directly after the operation (p less than 0.01). This was very specific for pain, which is one of the benefits of this technique and shown in this parameter which confirms the clinical impression. The curves of the changes in the different markers have been analysed and discussed.
authors.affiliation: Service de Gynécologie-Obstétrique, CHU Pitié-Salpêtrière, Paris.
authors.forename: G
authors.initials: G
authors.lastname: Lefebvre
authors.forename: A V
authors.initials: AV
authors.lastname: Thirion
authors.forename: D
authors.initials: D
authors.lastname: Vauthier-Brouzes
authors.forename: S
authors.initials: S
authors.lastname: Cohen
authors.forename: J
authors.initials: J
authors.lastname: Seebacher
authors.forename: Y
authors.initials: Y
authors.lastname: Darbois
authors.forename: J
authors.initials: J
authors.lastname: Antreassian
authors.forename: S
authors.initials: S
authors.lastname: Guillemant
authors.forename: M
authors.initials: M
authors.lastname: Lagoguet
authors.forename: C
authors.initials: C
authors.lastname: Landault
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D001835:Body Weight; D004298:Dopamine / Q000097:blood; D004837:Epinephrine / Q000097:blood; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007247:Infertility, Female / Q000601:surgery; D007431:Intraoperative Complications / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D010535:Laparoscopy / Q000009:adverse effects*; D007813:Laparotomy / Q000009:adverse effects*; D009638:Norepinephrine / Q000097:blood; D010048:Ovarian Cysts / Q000601:surgery; D011388:Prolactin / Q000097:blood; D013312:Stress, Physiological / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D013997:Time Factors; D001615:beta-Endorphin / Q000097:blood
chemical_list: D015415:Biomarkers; D001615:beta-Endorphin; D011388:Prolactin; D004298:Dopamine; D006854:Hydrocortisone; D009638:Norepinephrine; D004837:Epinephrine