Combination of treatment with perfluorochemicals and free radical scavengers.
P-cyclohexylmorpholine, given as oxygen carrier of second generation, was tested in two experimental models: the ischemic intestine and the lung under hyperbaric oxygen condition. In both instances in separated groups either alpha-tocopherol or allopurinol was additionally given as oxygen free radical scavenger. The thiobarbituric acid reaction (TBAR) was used as screening test for the occurrence of lipid peroxidation in organ probes; further the content of glutathione in reduced (GSH) and oxidized form (GSSG) was determined. Whereas only slight increases of TBAR substances and GSSG could be found compared to controls, the effect of the administrated scavenging drugs was very impressive: they could suppress nearly totally the effect of an enhanced oxidative stress.
Lutz
J
J
Physiologisches Institut, Univ. Wuerzburg, FRG.
Augustin
A J
AJ
Purucker
E
E
Milz
J
J
D000818:Animals; D001802:Blood Substitutes / Q000008:administration & dosage*; D005466:Fluorocarbons / Q000008:administration & dosage*; D016166:Free Radical Scavengers; D005978:Glutathione / Q000031:analogs & derivatives / Q000378:metabolism; D019803:Glutathione Disulfide; D006931:Hyperbaric Oxygenation; D007422:Intestines / Q000098:blood supply / Q000187:drug effects; D007511:Ischemia / Q000628:therapy; D015227:Lipid Peroxidation / Q000187:drug effects; D008168:Lung / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D001802:Blood Substitutes; D005466:Fluorocarbons; D016166:Free Radical Scavengers; D017392:Thiobarbituric Acid Reactive Substances; D005978:Glutathione; D019803:Glutathione Disulfide