title: Identification of metastatic disease by T category, gleason score and serum PSA level in patients with carcinoma of the prostate.
abstract: Pre-operative serum prostate specific antigen (Tandem-R assay), T category, Gleason score and the metastatic (M1) status of a consecutive series of 60 patients with newly diagnosed carcinoma of the prostate were studied prospectively. The results revealed that, of these variables, pre-operative serum PSA (greater than 100 ng/ml) was the single most important indicator of metastatic disease, with 100% predictive value. With this alone, 83.3% of M1 disease could be correctly identified. For the remaining 17%, however, we advocate a high index of suspicion if the tumour is T3-T4 category on digital rectal examination (predictive value = 71.4%) and has a high grade with a Gleason score 8-10 (predictive value = 81%).
authors.affiliation: University Department of Surgery/Urology, Western General Hospital, Edinburgh.
authors.forename: A
authors.initials: A
authors.lastname: Rana
authors.forename: K
authors.initials: K
authors.lastname: Karamanis
authors.forename: M G
authors.initials: MG
authors.lastname: Lucas
authors.forename: G D
authors.initials: GD
authors.lastname: Chisholm
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D017430:Prostate-Specific Antigen; D011471:Prostatic Neoplasms / Q000097:blood* / Q000556:secondary*
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen