title: Low dose cyclosporin A versus pulsed cyclophosphamide in Behçet's syndrome: a single masked trial.
abstract: A single masked trial of cyclosporin A 5 mg/kg/day versus monthly 1 g intravenous boluses of cyclophosphamide was conducted among 23 patients with Behçet's syndrome and active, potentially reversible uveitis. The trial was unmasked after a mean of 12 (SD 2) months for the cyclosporin A group (n = 12) and a mean of 10 (SD 3) months for the cyclophosphamide group (n = 11). During the initial 6 months the visual acuity significantly improved (p < 0.001) in the cyclosporin A group whereas this was not observed in the cyclophosphamide group. The subsequent follow-up of patients up to 24 months suggested that the initial improvement in visual acuity with cyclosporin A was not sustained. More extensive and especially long-term studies of cyclosporin A in the uveitis of Behçet's syndrome are warranted.
authors.affiliation: Department of Medicine, Cerrahpaşa Medical Faculty, University of Istanbul, Turkey.
authors.forename: Y
authors.initials: Y
authors.lastname: Ozyazgan
authors.forename: S
authors.initials: S
authors.lastname: Yurdakul
authors.forename: H
authors.initials: H
authors.lastname: Yazici
authors.forename: B
authors.initials: B
authors.lastname: Tüzün
authors.forename: A
authors.initials: A
authors.lastname: Işçimen
authors.forename: Y
authors.initials: Y
authors.lastname: Tüzün
authors.forename: T
authors.initials: T
authors.lastname: Aktunç
authors.forename: H
authors.initials: H
authors.lastname: Pazarli
authors.forename: V
authors.initials: V
authors.lastname: Hamuryudan
authors.forename: A
authors.initials: A
authors.lastname: Müftüoğlu
mesh_terms: D000293:Adolescent; D000328:Adult; D001528:Behcet Syndrome / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use*; D016572:Cyclosporine / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D016037:Single-Blind Method; D013997:Time Factors; D014792:Visual Acuity
chemical_list: D016572:Cyclosporine; D003520:Cyclophosphamide