The effects of normovolemic hemodilution with dextran-40 on acute myocardial ischemia/reperfusion injury in rabbits.
The effects of decreasing blood viscosity by normovolemic hemodilution with dextran-40 or normal saline (NS) on myocardial lipid peroxides, superoxide dismutase, infarct size and left ventricular function during acute myocardial ischemia/reperfusion were studied in rabbits. It was found that normovolemic hemodilution with dextran-40 could decrease the content of ischemic myocardial malondialdehyde and preserve ischemic myocardial superoxide dismutase activity after 1 h of coronary occlusion followed by 1 h of reperfusion. However, after administration of NS only a tendency in this aspect exhibited without statistical significance. Besides, hemodilution with dextran-40 reduced infarct size and improved left ventricular systolic function after 1 h of ischemia followed by 23 h of reperfusion. These results suggest that normovolemic hemodilution with dextran-40 may have anti-injury effect on acute myocardial ischemia/reperfusion to a certain degree.
Ruan
H D
HD
Department of Pathophysiology, Hubei Medical College, Wuhan.
Dong
C R
CR
Ling
H
H
D000818:Animals; D003327:Coronary Disease / Q000188:drug therapy*; D003911:Dextrans / Q000627:therapeutic use*; D005260:Female; D006438:Hemodilution; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D011817:Rabbits; D013482:Superoxide Dismutase / Q000378:metabolism
D003911:Dextrans; D008315:Malondialdehyde; D013482:Superoxide Dismutase