Salvage of infarcted myocardium by angiogenic action of basic fibroblast growth factor.
Coronary collateral vessels reduce damage to ischemic myocardium after coronary obstruction. Factors that stimulate collateral formation are expected to have ameliorating effects on myocardial infarction. In a canine experimental myocardial infarct model, intracoronary injection of basic fibroblast growth factor (bFGF) improved cardiac systolic function and reduced infarct size. Treatment with bFGF increased the number of arterioles and capillaries in the infarct. Thus, the angiogenic action of bFGF might lead to a reduction in infarct size. The application of bFGF might bring about a therapeutic modality for the salvage of infarcted myocardium.
Yanagisawa-Miwa
A
A
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
Uchida
Y
Y
Nakamura
F
F
Tomaru
T
T
Kido
H
H
Kamijo
T
T
Sugimoto
T
T
Kaji
K
K
Utsuyama
M
M
Kurashima
C
C
D000818:Animals; D001160:Arterioles / Q000473:pathology; D002196:Capillaries / Q000473:pathology; D002455:Cell Division; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000473:pathology; D004285:Dogs; D004730:Endothelium, Vascular / Q000473:pathology; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage / Q000627:therapeutic use*; D006352:Heart Ventricles / Q000473:pathology; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000473:pathology; D009389:Neovascularization, Pathologic; D009929:Organ Size
D016222:Fibroblast Growth Factor 2