CD8+ cutaneous anaplastic large-cell lymphoma: report of two cases with immunophenotyping, T-cell-receptor gene rearrangement and electron microscopic studies.
Two cases are reported of cutaneous anaplastic large-cell lymphoma with the suppressor/cytotoxic (CD8) phenotype. In both cases there was a solitary skin tumour in which there was a dense infiltrate with large irregularly shaped cells which on immunophenotyping expressed CD8. DNA hybridization analysis showed rearrangements of the T-cell-receptor gene in both cases.
Kikuchi
A
A
Department of Dermatology, Saiseikai Yokomashi Nanbu Hospital, Kanagawa, Japan.
Sakuraoka
K
K
Kurihara
S
S
Akiyama
M
M
Shimizu
H
H
Nishikawa
T
T
D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D018949:Antigens, CD1; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D017252:CD3 Complex; D016827:CD8 Antigens / Q000032:analysis*; D005260:Female; D015329:Gene Rearrangement, T-Lymphocyte / Q000235:genetics; D006801:Humans; D016130:Immunophenotyping / Q000379:methods; D007633:Keratins / Q000032:analysis; D017730:Ki-1 Antigen; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D015336:Molecular Probe Techniques; D011948:Receptors, Antigen, T-Cell / Q000032:analysis / Q000235:genetics; D012878:Skin Neoplasms / Q000235:genetics / Q000276:immunology* / Q000473:pathology
D015703:Antigens, CD; D018949:Antigens, CD1; D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm; D017252:CD3 Complex; D016827:CD8 Antigens; D017730:Ki-1 Antigen; D011948:Receptors, Antigen, T-Cell; D007633:Keratins