title: Leukemic phase of intermediate non-Hodgkin's lymphoma with cells showing different matured stages in invaded various organs.
abstract: A 56-year-old male was admitted to our hospital with lymphocytosis (16.4 x 10(9)/l; 79% lymphocytes including 50% small lymphocytes), generalized lymphadenopathy, massive splenomegaly, and heavily infiltrated bone marrow. Immunophenotype analysis of the neoplastic cells in the bone marrow revealed that they were B cells (CD20 + CD19 + Ia1 + sIgM+) positive for CD10. By contrast, the cells in the lymph node were CD20 + CD19 + Ia1 + sIgM+ but negative for CD10. The patient was tentatively diagnosed as having lymphosarcoma cell lymphoma, however, the final diagnosis was leukemic phase of intermediate lymphocytic lymphoma. We concluded that CD10+ neoplastic cells in the bone marrow and peripheral blood had differentiated to CD10- cells.
authors.affiliation: First Department of Internal Medicine, Tokyo Medical College, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shimamoto
authors.forename: K
authors.initials: K
authors.lastname: Ohyashiki
authors.forename: Y
authors.initials: Y
authors.lastname: Nehashi
authors.forename: T
authors.initials: T
authors.lastname: Tauchi
authors.forename: J H
authors.initials: JH
authors.lastname: Ohyashiki
authors.forename: K
authors.initials: K
authors.lastname: Toyama
mesh_terms: D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D002454:Cell Differentiation; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000276:immunology / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015260:Neprilysin; D009928:Organ Specificity
chemical_list: D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D015260:Neprilysin