[Drug modification of post-traumatic edema of the extremities by the proteinase inhibitor aprotinin. An animal experiment study].
Posttraumatic edema remains a serious problem in traumatology. Unrecognized or improperly treated, edema poses a threat to the survival of any extremity, particularly the hand, where a number of intricate functional structures are at stake. This study, as well as other recent clinical and experimental work, show that aprotinin, a proteinase inhibitor, is valuable in the treatment of posttraumatic edema, provided it is given as early as possible and in an adequate dosage.
Stoltz
J
J
Klinik und Poliklinik für Chirurgie des Bereiches Medizin, Rudolf-Elle-Waldkrankenhauses Eisenberg/Thüringen.
Zollmann
P
P
Dorow
C
C
Schwarz
J
J
Schubert
H
H
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000503:physiopathology*; D005552:Forelimb / Q000098:blood supply / Q000293:injuries; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D014947:Wounds and Injuries / Q000503:physiopathology*
D007611:Aprotinin