Localization of the fibroblast growth factor receptor-4 gene to chromosome region 5q33-qter.
Our polymerase chain reaction cloning of novel tyrosine kinases expressed in the K562 chronic myeloid leukemia cells has revealed a novel fibroblast growth factor receptor, FGFR4. We have here mapped the FGFR4 gene by analysis of somatic cell hybrids and in situ hybridization to the 5q33-qter chromosomal region. This finding is of interest in that the FGFR4 gene is expressed in several leukemia cell lines and the 5q33-qter region is involved in nonrandom chromosomal translocations in acute myelogenous leukemias and Ki-I lymphomas.
Armstrong
E
E
Department of Virology, University of Helsinki, Finland.
Partanen
J
J
Cannizzaro
L
L
Huebner
K
K
Alitalo
K
K
D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5; D005346:Fibroblast Growth Factors; D015973:Gene Expression Regulation, Leukemic; D005796:Genes; D006801:Humans; D007938:Leukemia / Q000235:genetics / Q000473:pathology; D004915:Leukemia, Erythroblastic, Acute / Q000235:genetics / Q000473:pathology; D008223:Lymphoma / Q000235:genetics / Q000473:pathology; D009363:Neoplasm Proteins / Q000235:genetics; D016133:Polymerase Chain Reaction; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D051499:Receptor, Fibroblast Growth Factor, Type 4; D011956:Receptors, Cell Surface / Q000235:genetics*; D017468:Receptors, Fibroblast Growth Factor; D014178:Translocation, Genetic; D014407:Tumor Cells, Cultured / Q000648:ultrastructure
D009363:Neoplasm Proteins; D011956:Receptors, Cell Surface; D017468:Receptors, Fibroblast Growth Factor; D005346:Fibroblast Growth Factors; C496371:FGFR4 protein, human; D011505:Protein-Tyrosine Kinases; D051499:Receptor, Fibroblast Growth Factor, Type 4