Antitumor agents. 134. New shiraiachrome-A- and calphostin-C-related perylene derivatives as cytotoxic and antiviral agents and inhibitors of protein kinase C.
Shiraiachrome-A and -B have been isolated from the mycelium of the Chinese bamboo fungus Shiraia bambusicola as the cytotoxic principles. A series of new perylene derivatives (7-27) related to Shiraiachrome-A and -B as well as Calphostin-C have been synthesized and evaluated for their cytotoxicity, antiviral activity, and inhibitory activity against protein kinase C. The results indicated that 11 and 12 are potent cytotoxic agents against HCT-8, RPMI-7951, and TE-671 solid tumor cells, whereas 24 and 26 demonstrated strong antiviral activity against HSV-1 and HSV-2. Compound 10 is an inhibitor of protein kinase C.
Wang
H K
HK
Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599.
Xie
J X
JX
Chang
J J
JJ
Hwang
K M
KM
Liu
S Y
SY
Ballas
L M
LM
Jiang
J B
JB
Lee
K H
KH
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009281:Naphthalenes; D010569:Perylene / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D011083:Polycyclic Compounds / Q000737:chemistry / Q000494:pharmacology*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D018139:Simplexvirus / Q000187:drug effects; D014407:Tumor Cells, Cultured; D014709:Vero Cells
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D009281:Naphthalenes; D011083:Polycyclic Compounds; C075921:Shiraiachrome A; D010569:Perylene; D011493:Protein Kinase C; C058819:calphostin C