title: [Massive fetal-maternal hemorrhage at term associated with a choriocarcinoma].
abstract: A case of malignant choriocarcinoma produced a major feto-maternal transfusion at term. This was proven using routine Kleihauer's test. The newborn died on the 5th day of life from haemorrhagic shock. The diagnosis of choriocarcinoma was made when acute post-partum haemorrhage occurred together with a high level of Beta HCG. The patient was cured by the use of Methotrexate followed by four courses of tri-chemotherapy (Methotrexate, Actinomycin and Cyclophosphamide). After treatment for secondary infertility, the patient had two normal pregnancies. This case makes possible to point out again the possible association of a positive Kleihauer test with choriocarcinoma. It also points out strongly the value of carrying out Beta HCG testing when bleeding occurs post-partum. Early diagnosis improves the maternal prognosis and allows conservative treatment to be carried out in cases of choriocarcinoma in young women.
authors.affiliation: Unité d'Obstétrique, Université de Louvain, Cliniques Universitaires Saint-Luc, Bruxelles, Belgium.
authors.forename: I
authors.initials: I
authors.lastname: Theunissen
authors.forename: S
authors.initials: S
authors.lastname: Gosseye
authors.forename: M
authors.initials: M
authors.lastname: Van Lierde
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002822:Choriocarcinoma / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D006063:Chorionic Gonadotropin / Q000097:blood; D018997:Chorionic Gonadotropin, beta Subunit, Human; D003520:Cyclophosphamide / Q000008:administration & dosage; D003609:Dactinomycin / Q000008:administration & dosage; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005331:Fetomaternal Transfusion / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage; D010446:Peptide Fragments / Q000097:blood; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011379:Prognosis; D014594:Uterine Neoplasms / Q000097:blood / Q000150:complications* / Q000188:drug therapy
chemical_list: D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments; D003609:Dactinomycin; D003520:Cyclophosphamide; D008727:Methotrexate