title: Induction of endogenous retroviral gene product (SU) as an acute-phase protein by IL-6 in murine hepatocytes.
abstract: The effect of Lps locus and IL-6 on the production of SU (previously termed gp70), a mouse endogenous retroviral gene product, was studied. Back-cross studies using the progeny between (NZB x C3H/HeJ)F1 and C3H/HeJ mice indicate that the basal level of SU is not associated with the Lps locus on chromosome 4. Lipopolysaccharide (LPS) mitogen response-negative mice did not show the enhancement of serum SU production after LPS injection. Spleen cells from LPS-mitogen response-positive but not from negative mice showed increase of IL-6 synthesis in the presence of LPS. Since IL-6 may be involved in the production of serum SU, we tested the effect of IL-6 in a primary hepatocyte culture system. SU production was clearly enhanced in the presence of recombinant IL-6, indicating that IL-6 induced by LPS can enhance the expression of retroviral genome.
authors.affiliation: Department of Molecular Pathology, Tokyo Metropolitan Institute of Gerontology, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Itoh
authors.forename: N
authors.initials: N
authors.lastname: Maruyama
authors.forename: M
authors.initials: M
authors.lastname: Kitamura
authors.forename: T
authors.initials: T
authors.lastname: Shirasawa
authors.forename: K
authors.initials: K
authors.lastname: Shigemoto
authors.forename: T
authors.initials: T
authors.lastname: Koike
mesh_terms: D000209:Acute-Phase Proteins / Q000096:biosynthesis*; D000818:Animals; D002478:Cells, Cultured; D003433:Crosses, Genetic; D005260:Female; D015850:Interleukin-6 / Q000096:biosynthesis / Q000494:pharmacology*; D008070:Lipopolysaccharides; D008099:Liver / Q000378:metabolism*; D051379:Mice; D008809:Mice, Inbred C3H; D008811:Mice, Inbred DBA; D008814:Mice, Inbred NZB; D011994:Recombinant Proteins / Q000494:pharmacology; D015682:Retroviridae Proteins, Oncogenic / Q000096:biosynthesis*; D014158:Transcription, Genetic / Q000187:drug effects; D014759:Viral Envelope Proteins / Q000096:biosynthesis*
chemical_list: D000209:Acute-Phase Proteins; D015850:Interleukin-6; D008070:Lipopolysaccharides; D011994:Recombinant Proteins; D015682:Retroviridae Proteins, Oncogenic; D014759:Viral Envelope Proteins