Synergistic antiproliferative effect of interferons and azidothymidine on HL60 cells.
Proliferation of human leukemia cells, HL60, was synergistically inhibited by a combination of human interferons and azidothymidine in vitro. Combination of interferon-gamma (3000 U/ml) and azidothymidine (30 microM) inhibited cell growth by 76%, whereas interferon-gamma alone suppressed growth by 23% and azidothymidine alone by 33%. Interferon-alpha-2a and interferon-beta also exerted synergistic effects with azidothymidine, but the potentiation was weaker than that by the combination of interferon-gamma and aziodthymidine.
Nakae
H
H
Kobe Women's College of Pharmacy, Motoyama Kitamachi, Japan.
Asada
S
S
D002455:Cell Division / Q000187:drug effects*; D004357:Drug Synergism; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000494:pharmacology; D016899:Interferon-beta / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology; D007372:Interferons / Q000494:pharmacology*; D007942:Leukemia, Experimental / Q000473:pathology*; D011994:Recombinant Proteins; D014407:Tumor Cells, Cultured; D015215:Zidovudine / Q000494:pharmacology*
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D015215:Zidovudine; D016899:Interferon-beta; D007371:Interferon-gamma; D007372:Interferons