Hepatitis C virus infection in chronic liver disease in Bombay.
To find out the prevalence of antibody of hepatitis C virus (anti-HCV) in patients with chronic liver disease in Bombay, sera from 126 patients (93 men, 33 women; aged 9-70 years, mean 39.7) with chronic liver disease (cirrhosis 103, cirrhosis with hepatocellular carcinoma 3, chronic active hepatitis 20) were tested for HBsAg and anti-HCV antibody. HBsAg positive sera were tested for anti-delta antibody and IgM anti-HBc. All the tests were carried out by ELISA. Of 126 patients, 51 (40.5%) were HBsAg positive, 49 (38.8%) alcoholic and 21 (16.6%) anti-HCV positive. The prevalence of anti-HCV in HBsAg positive, alcoholic and cryptogenic (HBV negative and no alcohol) liver disease patients was 13.7%, 14.7% and 20.5% respectively. Of 21 anti-HCV antibody positive patients, 8 (38%) had received blood transfusions previously. HCV is present in 15-20% of patients with chronic liver disease in Bombay.
Amarapurkar
D N
DN
Department of Gastroenterology, B Y L Nair Charitable Hospital, Bombay.
Kumar
A
A
Parikh
S S
SS
Chopra
K B
KB
Murti
P
P
Kalro
R H
RH
Desai
H G
HG
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002908:Chronic Disease; D005260:Female; D016174:Hepacivirus / Q000276:immunology; D006508:Hepatitis Antibodies / Q000032:analysis*; D006526:Hepatitis C / Q000453:epidemiology; D018937:Hepatitis C Antibodies; D006801:Humans; D007194:India / Q000453:epidemiology; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008107:Liver Diseases / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D016036:Seroepidemiologic Studies
D006508:Hepatitis Antibodies; D018937:Hepatitis C Antibodies