title: Bioactive polymers. 70. The kinetics of controlled release of neomycin in an alkaline medium.
abstract: Neomycin is coupled on xanthan--a polysaccharide of microbial biosynthesis produced by Xanthomona campestris--through ionic complexation. The kinetics of neomycin release, in vitro, at pH = 8.2 is studied. A release of neomycin, following a zero order kinetics, is observed, regardless of the eluent flow-rate. The neomycin-xanthan complex, protected by a cellulosic membrane, behaves like a monolithic-type device. Diffusion coefficients--increasing with increasing the eluent flow-rate--are also calculated.
authors.affiliation: Polytechnic Institute of Jassy, Romania.
authors.forename: S
authors.initials: S
authors.lastname: Dumitriu
authors.forename: N
authors.initials: N
authors.lastname: Aelenei
authors.forename: I M
authors.initials: IM
authors.lastname: Popa
authors.forename: M
authors.initials: M
authors.lastname: Dumitriu
authors.forename: D
authors.initials: D
authors.lastname: Dumitriu
mesh_terms: D003692:Delayed-Action Preparations; D004058:Diffusion; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D009355:Neomycin / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology; D011108:Polymers; D011135:Polysaccharides, Bacterial; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D003692:Delayed-Action Preparations; D011108:Polymers; D011135:Polysaccharides, Bacterial; D009355:Neomycin; C002563:xanthan gum