Sucralphate in the prevention of acute gastric lesions induced by ischemia-reperfusion.
The role of sucralphate in prevention of acute gastric injuries and its comparison with free radical blockers such as allopurinol, soybean trypsin inhibitor and superoxidase dismutase in the ischemia-reperfusion model by total occlusion of the coeliac artery in Wistar rats, was studied. The gross gastric mucosal necrotic area was 80%. In contrast with the antioxidant drugs the necrotic area attained was between 7 to 15%, while with sucralphate, an antioxidant-cytoprotective drug that enhances the gastric defensive barrier, the prevention of the secondary aggression induced by free radicals was more important.
Laudanno
O M
OM
Cátedras de Patología Médica III (Gastroenterología) y de Histología, Facultad de Ciencias Médicas, Rosario, Argentina.
Bedini
O A
OA
Cesolari
J A
JA
San Miguel
P
P
D000208:Acute Disease; D000493:Allopurinol / Q000494:pharmacology; D000818:Animals; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000473:pathology / Q000517:prevention & control*; D013270:Stomach / Q000098:blood supply; D013276:Stomach Ulcer / Q000517:prevention & control; D013392:Sucralfate / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000494:pharmacology; D014360:Trypsin Inhibitor, Kunitz Soybean / Q000494:pharmacology
D013392:Sucralfate; D000493:Allopurinol; D014360:Trypsin Inhibitor, Kunitz Soybean; D013482:Superoxide Dismutase