The metabotropic excitatory amino acid receptor agonist 1S,3R-ACPD selectively potentiates N-methyl-D-aspartate-induced brain injury.
The role of metabotropic type excitatory amino acid receptors in brain injury was assessed using the selective metabotropic receptor agonist, (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD). Intrastriatal stereotaxic injection of 1S,3R-ACPD (250 nmol) in PND 7 rats produced little brain injury as assessed by hemispheric weight disparities. However, 1S,3R-ACPD markedly potentiated N-methyl-D-aspartate (NMDA)-, but not alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA)-, mediated brain injury. This effect was stereoselective since the inactive metabotropic agonist, 1R,3S-ACPD, did not potentiate NMDA toxicity.
McDonald
J W
JW
CNS Research, Eli Lilly and Company, Indianapolis, IN 46285.
Schoepp
D D
DD
D000818:Animals; D001921:Brain / Q000187:drug effects*; D003515:Cycloleucine / Q000031:analogs & derivatives* / Q000633:toxicity; D004357:Drug Synergism; D007051:Ibotenic Acid / Q000031:analogs & derivatives / Q000633:toxicity; D066298:In Vitro Techniques; D016202:N-Methylaspartate / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D017459:Receptors, Amino Acid / Q000187:drug effects*; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
D017459:Receptors, Amino Acid; D003515:Cycloleucine; C036361:1-amino-1,3-dicarboxycyclopentane; D007051:Ibotenic Acid; D016202:N-Methylaspartate; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid