title: Cefaclor concentrations in human serum, gingiva, mandibular bone, and dental follicle following a single oral administration.
abstract: 1. Cefaclor concentrations in human serum (n = 59), gingiva (n = 46), mandibular bone (n = 39), and dental follicle (n = 42) following a single oral administration of cefaclor (500 mg) were measured by the paper disk method. 2. The peak times of serum, gingiva, mandibular bone, and dental follicle were 1.5, 2, 2, and 1.5 hr, respectively. 3. The mean peak concentrations of serum, gingiva, mandibular bone, and dental follicle were 7.58 micrograms/ml, 3.71, 1.59 and 2.42 micrograms/g, respectively. 4. The concentration ratios of gingiva/serum, mandibular bone/serum, and dental follicle/serum at peak times of the tissues were 0.49, 0.18, and 0.32, respectively. 5. Mean cefaclor concentrations in gingiva, mandibular bone, and dental follicle at peak times exceeded MIC for 90% for clinically isolated strains of alpha-hemolytic Streptococci.
authors.affiliation: Second Department of Oral Surgery, Nihon University School of Dentistry, Matsudo, Chiba, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Akimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Mochizuki
authors.forename: A
authors.initials: A
authors.lastname: Uda
authors.forename: H
authors.initials: H
authors.lastname: Omata
authors.forename: J
authors.initials: J
authors.lastname: Shibutani
authors.forename: H
authors.initials: H
authors.lastname: Nishimura
authors.forename: M
authors.initials: M
authors.lastname: Komiya
authors.forename: K
authors.initials: K
authors.lastname: Kaneko
authors.forename: A
authors.initials: A
authors.lastname: Fujii
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002433:Cefaclor / Q000097:blood / Q000493:pharmacokinetics*; D002506:Cephalexin / Q000493:pharmacokinetics; D003795:Dental Sac / Q000378:metabolism*; D005260:Female; D005881:Gingiva / Q000378:metabolism*; D006801:Humans; D008297:Male; D008334:Mandible / Q000378:metabolism*; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D013291:Streptococcus / Q000187:drug effects
chemical_list: D002433:Cefaclor; D002506:Cephalexin