In vivo modulation of myelin gene expression by human recombinant IL-2.
We treated adult mice with human recombinant interleukin-2 (IL-2) and determined the expression of the genes encoding for the major central and peripheral myelin proteins. In the CNS, myelin basic protein (MBP) and myelin-associated glycoprotein (MAG) mRNA levels were the same both in IL-2-treated and in control mice. Proteolipid protein (PLP) transcript was decreased in IL-2-treated animals when compared to controls. In the PNS, the messages for the glycoprotein P0 and for MBP were markedly increased in IL-2-treated animals when compared to controls.
Sessa
M
M
Department of Neurology, University of Milan, IRCCS Hospital San Raffaele, Italy.
Nemni
R
R
Iannaccone
S
S
Quattrini
A
A
Confalonieri
V
V
Canal
N
N
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D015342:DNA Probes; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009185:Myelin Proteins / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D012313:RNA / Q000235:genetics / Q000302:isolation & purification; D012333:RNA, Messenger / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism; D011994:Recombinant Proteins / Q000494:pharmacology; D012584:Sciatic Nerve / Q000187:drug effects / Q000502:physiology*
D015342:DNA Probes; D007376:Interleukin-2; D009185:Myelin Proteins; D012333:RNA, Messenger; D011994:Recombinant Proteins; D012313:RNA