Event-related EEG potentials in mild dementia of the Alzheimer type.
Most studies on event-related EEG potentials in dementia have focussed on the P3 component and used auditory stimuli only. In the present study, N2b was analysed in the usual auditory oddball task in addition to P3, and a visual task was employed ("Push"/"Wait"), with recordings including an occipital scalp site. Seven Alzheimer-type patients, with their mean IQ still in the normal range, were compared to age-matched normal controls. In the oddball task, P3 did not differ between groups but the patients' N2b was delayed. The main difference in the Push/Wait task was in an occipital P270, which component was distinctly larger in the patients. It is suggested that both differences reflect the disintegration of patients' cognition: stimuli are perceived in a normal way but then a gap arises due to uncertainty what to do with the perceived event.
Verleger
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Klinik für Neurologie, Medizinische Universität zu Lübeck, F.R.G.
Kömpf
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Neukäter
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D000161:Acoustic Stimulation; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000503:physiopathology*; D000704:Analysis of Variance; D004569:Electroencephalography; D004585:Electrooculography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013647:Task Performance and Analysis