Telomere association of human chromosomes induced by aphidicolin.
Telomere associations were studied in metaphase chromosomes from 96-h cultures of peripheral blood lymphocytes of two healthy women, treated with 0.4 microM aphidicolin for the last 72 h. Telomere associations were encountered in 2.9% and 3.2% of the metaphases screened, whereas no such associations were encountered in 5-fluorodeoxyuridine-treated cultures. The chromosome arms involved in telomere associations were nonrandom: 1q, 2q, 3q, 6p and 16q were more frequently involved in the associations (P less than 0.01). Of the 51 combinations of telomere associations encountered, those occurring nonrandomly were 1q/2q, 2q/2q, 4q/4q, 6q/6q and 6p/6p associations.
Kuwano
A
A
Department of Pediatrics, Yamaguchi University School of Medicine, Ube, Japan.
Matsuura
S
S
Kajii
T
T
D000328:Adult; D016590:Aphidicolin / Q000494:pharmacology*; D002478:Cells, Cultured; D002877:Chromosomes, Human / Q000187:drug effects*; D005260:Female; D005467:Floxuridine / Q000494:pharmacology; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000648:ultrastructure; D016615:Telomere / Q000187:drug effects*
D005467:Floxuridine; D016590:Aphidicolin