Characterisation of a novel repetitive DNA sequence from Mycobacterium bovis.
We report characterisation of three copies of a novel repeat sequence isolated from a Mycobacterium bovis genomic library. The repeat occurs within open reading frames, potentially encoding a conserved tandem array of a pentapeptide sequence with the consensus X-Gly-Asn-X-Gly. The tandem array is present up to five times in M. bovis and it is proposed that they may occur in a family of genes expressing functionally related proteins. We postulate that these proteins may play a role in binding of M. bovis to host cell receptors.
Doran
T J
TJ
CSIRO Division of Animal Health, Animal Health Research Laboratory, Parkville, Australia.
Hodgson
A L
AL
Davies
J K
JK
Radford
A J
AJ
D000595:Amino Acid Sequence; D001483:Base Sequence; D004269:DNA, Bacterial / Q000235:genetics*; D015698:Genomic Library; D008969:Molecular Sequence Data; D009163:Mycobacterium bovis / Q000235:genetics*; D016366:Open Reading Frames; D012091:Repetitive Sequences, Nucleic Acid; D016415:Sequence Alignment
D004269:DNA, Bacterial