Effects of gamma interferon and indomethacin in preventing Brucella abortus infections in mice.
Increased resistance to infection with Brucella abortus 2308 resulted when recombinant murine gamma interferon (rMuIFN-gamma) was given to mice both before and during infection but not when given only before infection. Mice given rMuIFN-gamma had enhanced peritoneal and splenic macrophage bactericidal activity against B. abortus. Treatment of mice with rMuIFN-gamma plus indomethacin did not further enhance resistance to infection or macrophage bactericidal activity compared with that after treatment of mice with rMuIFN-gamma alone.
Stevens
M G
MG
Brucellosis Research Unit, National Animal Disease Center, Ames, Iowa 50010.
Pugh
G W
GW
Tabatabai
L B
LB
D000818:Animals; D002003:Brucella abortus; D002006:Brucellosis / Q000276:immunology / Q000517:prevention & control*; D007113:Immunity, Innate / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology*; D007371:Interferon-gamma / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D011453:Prostaglandins / Q000502:physiology; D011994:Recombinant Proteins
D011453:Prostaglandins; D011994:Recombinant Proteins; D007371:Interferon-gamma; D007213:Indomethacin