Killing curve activity of ciprofloxacin is comparable to synergistic effect of beta-lactam-tobramycin combinations against Haemophilus species endocarditis strains.
Nine Haemophilus species strains, all beta-lactamase negative, isolated from patients with endocarditis were tested in killing curve experiments. Antibiotics used were penicillin, amoxicillin, aztreonam alone and in combination with tobramycin, as well as ciprofloxacin alone. Synergism between beta-lactams and tobramycin with reduction of colony counts to zero was seen after 24 h for H. influenzae, H. parainfluenzae and H. segnis strains. Ciprofloxacin was as effective as beta-lactam-tobramycin combinations. The H. aphrophilus strain was not killed as effectively as other strains by any of the antibiotics.
Westh
H
H
Department of Clinical Microbiology, Bispebjerg Hospital, Copenhagen, Denmark.
Frimodt-Møller
N
N
Gutschik
E
E
Bangsborg
J
J
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D004357:Drug Synergism; D004697:Endocarditis, Bacterial / Q000382:microbiology*; D006190:Haemophilus / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D014031:Tobramycin / Q000494:pharmacology*; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D002939:Ciprofloxacin; D014031:Tobramycin