title: Teicoplanin vs cephradine and metronidazole in the prophylaxis of sepsis following vascular surgery: an interim analysis of an ongoing trial.
abstract: This paper presents further preliminary results of a trial of the prophylaxis of sepsis in 165 patients undergoing vascular surgery. The efficacy and safety of a single dose of teicoplanin was examined and compared with three doses of cephradine plus metronidazole. No significant differences were detected in the prophylactic efficacy in either group. The first interim report indicated abnormalities in liver function, maximum at 7 days, in both groups. These findings are confirmed in this second interim report. Raised levels of GGT and alkaline phosphatase are more prominent in patients receiving teicoplanin. Liver function improved by 28 days, however, suggesting that any abnormality is transient.
authors.affiliation: Department of Vascular Surgery, St James's University Hospital, Leeds, UK.
authors.forename: R M
authors.initials: RM
authors.lastname: Antrum
authors.forename: K
authors.initials: K
authors.lastname: Galvin
authors.forename: K
authors.initials: K
authors.lastname: Gorst
authors.forename: C A
authors.initials: CA
authors.lastname: Thornton
authors.forename: M
authors.initials: M
authors.lastname: Lansdown
authors.forename: R C
authors.initials: RC
authors.lastname: Kester
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002515:Cephradine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006020:Glycopeptides / Q000627:therapeutic use; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use*; D008875:Middle Aged; D011292:Premedication; D013530:Surgical Wound Infection / Q000517:prevention & control*; D017334:Teicoplanin; D014656:Vascular Surgical Procedures; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D008795:Metronidazole; D017334:Teicoplanin; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D002515:Cephradine