Inhibition of peptide release from invertebrate neurons by the protein kinase inhibitor H-7.
The protein kinase inhibitor H-7 has been shown to prevent the potentiation of action potentials that normally accompanies an afterdischarge in the bag cell neurons of Aplysia. We have now shown that H-7 attenuates the release of ELH from these neurons during an afterdischarge without influencing the firing frequency or length of the afterdischarge.
Loechner
K J
KJ
Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510.
Mattessich-Arrandale
J
J
Azhderian
E M
EM
Kaczmarek
L K
LK
D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001048:Aplysia; D004558:Electric Stimulation; D005724:Ganglia / Q000502:physiology*; D066298:In Vitro Techniques; D007447:Invertebrate Hormones / Q000378:metabolism*; D007546:Isoquinolines / Q000494:pharmacology*; D007700:Kinetics; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D010879:Piperazines / Q000494:pharmacology*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*
D007447:Invertebrate Hormones; D007546:Isoquinolines; D010879:Piperazines; C026880:egg-laying hormone, Mollusca; D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D011493:Protein Kinase C