Neurotransmitter transporters (plus): a promising new gene family.
Neurotransmitter transporter genes encode proteins with 12 putative transmembrane regions, which mediate Na(+)-dependent reaccumulation of released neurotransmitters into presynaptic terminals and are the sites of action of important abused and therapeutic drugs. Studies of these genes show promise for improving our understanding of transport mechanisms and modes of drug action, and may even uncover previously unanticipated neurotransmitters.
Uhl
G R
GR
Laboratory of Molecular Neurobiology, National Institute on Drug Abuse, MD.
D000595:Amino Acid Sequence; D000818:Animals; D001693:Biological Transport, Active; D015415:Biomarkers; D001923:Brain Chemistry; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D004247:DNA / Q000235:genetics; D004058:Diffusion; D050483:Dopamine Plasma Membrane Transport Proteins; D050485:GABA Plasma Membrane Transport Proteins; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism*; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D008969:Molecular Sequence Data; D005810:Multigene Family; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D050484:Norepinephrine Plasma Membrane Transport Proteins; D027361:Organic Anion Transporters; D011487:Protein Conformation; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D050486:Serotonin Plasma Membrane Transport Proteins; D012964:Sodium / Q000378:metabolism; D013329:Structure-Activity Relationship; D027981:Symporters; D009435:Synaptic Transmission
D015415:Biomarkers; D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D050485:GABA Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents; D050484:Norepinephrine Plasma Membrane Transport Proteins; D027361:Organic Anion Transporters; D011993:Recombinant Fusion Proteins; C493227:SLC6A2 protein, human; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D027981:Symporters; D004247:DNA; D012964:Sodium