A plasminogen-related gene is expressed in cancer cells.
The breakdown of blood clots requires the fibrinolytic action of the serine proteinase plasmin, a two-chain polypeptide derived posttranslationally from its precursor zymogen, plasminogen. While investigating plasminogen gene expression in human extrahepatic tissues, a cDNA sequence was obtained which closely resembled the plasminogen cDNA, yet appeared to represent a distinct gene product. This sequence, which represents the transcript of the recently characterized plasminogen-related gene B, encodes a putative polypeptide of Mr 8800 and is expressed most prominently in malignant cancer cells.
Weissbach
L
L
Orthopaedic Research Laboratories, Massachusetts General Hospital, Boston 02114.
Treadwell
B V
BV
D000328:Adult; D000368:Aged; D000595:Amino Acid Sequence; D001483:Base Sequence; D001859:Bone Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D001943:Breast Neoplasms / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D004273:DNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D015870:Gene Expression; D006801:Humans; D008099:Liver / Q000201:enzymology; D008175:Lung Neoplasms / Q000201:enzymology / Q000235:genetics / Q000556:secondary*; D008969:Molecular Sequence Data; D009367:Neoplasm Staging; D012516:Osteosarcoma / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D010958:Plasminogen / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000379:methods; D012313:RNA / Q000235:genetics / Q000302:isolation & purification; D015183:Restriction Mapping
D004273:DNA, Neoplasm; D012313:RNA; D010958:Plasminogen