Abnormalities in immune regulation precede the development of multiple myeloma.
Immunosuppression of immunoglobulin synthesis seen in patients with multiple myeloma is in part due to immunosuppressive CD5 positive B cells. In a 13 year longitudinal study of an IgA-deficient blood donor who developed multiple myeloma, the presence of immunosuppressive CD5 positive B cells and T cells preceded the diagnosis of overt multiple myeloma and the appearance of immunosuppressive monocytes. These data argue that certain immune defects may be involved in the development of myeloma and are not simply a consequence of overt malignancy.
Paglieroni
T
T
Sacramento Medical Foundation, Center for Blood Research, CA 95816-7089.
Caggiano
V
V
MacKenzie
M
M
D000917:Antibody Formation; D015703:Antigens, CD / Q000032:analysis; D001782:Blood Donors; D018956:CD5 Antigens; D006801:Humans; D017098:IgA Deficiency; D016131:Lymphocyte Subsets; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000209:etiology* / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000502:physiology; D013997:Time Factors
D015703:Antigens, CD; D018956:CD5 Antigens