Immunoregulatory capability of murine CLL-like CD5+ B cells.
NZB mice spontaneously develop clones of hyperdiploid CD5+B cells, which are much like the malignant cells of CLL. We have found that these clonal CD5+B cells are immunoregulatory. The development of these cells is accompanied by the loss of detectable normal percentages of IgM+ B220(6B2)+ B cells secondary to hyperplasia of splenic non-B cells, which are positively regulated by the hyperdiploid B-cell clone.
Phillips
J
J
Albany Medical College, New York.
Raveché
E
E
D000818:Animals; D015703:Antigens, CD / Q000032:analysis / Q000276:immunology*; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D018956:CD5 Antigens; D004171:Diploidy; D007942:Leukemia, Experimental / Q000276:immunology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D012016:Reference Values; D013154:Spleen / Q000276:immunology
D015703:Antigens, CD; D018956:CD5 Antigens