Event-related potential measurement of deficits in information processing following moderate to severe closed head injury.
Event-related potentials may offer more precision than behavioural measures for understanding the extent and timing of information processing difficulties that follow closed head injury (CHI). Behavioural tests consistently indicate a general reduction in cognitive function but lack adequate diagnostic or prognostic function. This study compares a group of seven CHI patients, in which time since injury varied between 1 and 5 years following injury, with 10 matched controls on a three-tone discrimination task. Abnormality in the processing of tones as early as 200 ms following their onset, as measured by the P2 and N2 components of the event-related potential, indicated a general difficulty with tone discrimination. This abnormality was obtained despite differing damage profiles over patients and is likely to be due to the diffuse aspects of damage normal in CHI. These results also indicate that functional deficits in CHI patients can extend up to 5 years or more. A correlation between P2/N2 amplitudes and time since injury, however, suggests that both these components normalize with the passage of time and offers the prospect of a sensitive, non-behavioural measure of recovery in cognitive processing.
Clark
C R
CR
Cognitive Neuroscience Laboratory, Flinders University of South Australia, Adelaide, Australia.
O'Hanlon
A P
AP
Wright
M J
MJ
Geffen
G M
GM
D000293:Adolescent; D000328:Adult; D000647:Amnesia / Q000175:diagnosis / Q000503:physiopathology; D001925:Brain Damage, Chronic / Q000175:diagnosis / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000502:physiology*; D004569:Electroencephalography / Q000295:instrumentation*; D005072:Evoked Potentials, Auditory / Q000502:physiology; D005500:Follow-Up Studies; D016489:Head Injuries, Closed / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000175:diagnosis / Q000503:physiopathology*; D010897:Pitch Discrimination / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*