Perfluoroalkylated surfactants: relationships between structure and acute toxicity in mice.
New single chain neutral, and single and double chain zwitterionic perfluoroalkylated surfactants or co-surfactants have been evaluated for in vivo applications. A study of the relationship between structure and acute toxicity in mice is presented. Acute toxicity evaluations i.v. in mice indicate the following trends (increasing tolerance): zwitterionic single-chain less than neutral single-chain less than zwitterionic double-chain and, where the polar head is concerned, single-chain compounds: phosphocholine less than phosphoramidate less than trehalose approximately sucrose less than maltose less than xylitol.
Mahé
A M
AM
Centre de Transfusion Sanguine des Alpes Maritimes, St Laurent du Var, France.
Manoux
J
J
Valla
A
A
Follana
R
R
Zarif
L
L
Greiner
J
J
Vierling
P
P
Riess
J G
JG
D000818:Animals; D001802:Blood Substitutes / Q000737:chemistry / Q000633:toxicity; D002240:Carbohydrate Sequence; D003287:Contrast Media / Q000737:chemistry / Q000633:toxicity; D005466:Fluorocarbons / Q000737:chemistry / Q000633:toxicity*; D051379:Mice; D008969:Molecular Sequence Data; D013329:Structure-Activity Relationship; D013501:Surface-Active Agents / Q000737:chemistry / Q000633:toxicity*
D001802:Blood Substitutes; D003287:Contrast Media; D005466:Fluorocarbons; D013501:Surface-Active Agents