[The effect of streptozotocin diabetes on lipid levels in the myocardium in young rats].
The effect of intraperitoneally administered streptozotocin was studied in 8-, 10-, and 12-week-old rats. The total triacylglycerol content was found to be significantly increased in all the three groups studied, and that by 59.64% in the 8-week old group, by 54.86% in the 10-week-old group, and by 50.57% in the 12-week-old group. The level of total phospholipids increased only in the 8-week-old group of diabetic animals, and that by 11.09%, whereas in the other age groups studied it remained unchanged. In the level of individual phospholipids changes occurred in 8-week-old rats, namely phosphatidylcholine increased by 53.0% and sphingomyelin by 23.8%. In 10- and 12-week-old diabetic rats the only change was recorded in the level of cardiolipin which increased by 54.23% in 12-week-old animals.
Kvaszová
E
E
Ustav patologickej fyziológie LFUK v Bratislave a Ustav súdneho lekárstva LFUK v Bratislave.
Zlatos
L
L
Valúch
J
J
D000367:Age Factors; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D050356:Lipid Metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
D013311:Streptozocin