Mitochondrial function in neurodegeneration and ageing.
The mitochondrial respiratory chain and oxidative phosphorylation system are responsible for the production of ATP by aerobic metabolism. Defects of the respiratory chain are increasingly recognised as important causes of human disease, and neurodegenerative disorders in particular. This article will seek to review the clinical and biochemical effects of respiratory chain defects, and summarise what is known about the molecular mechanisms that underlie them. Increasing age is also associated with a decline in mitochondrial function. The biochemical correlates of this dysfunction and the possible molecular defects that may cause it will also be reviewed.
Schapira
A H
AH
Department of Neuroscience, Royal Free Hospital School of Medicine, London, UK.
Cooper
J M
JM
D000375:Aging / Q000502:physiology*; D000818:Animals; D004272:DNA, Mitochondrial / Q000235:genetics; D017353:Gene Deletion; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D017237:Mitochondrial Encephalomyopathies / Q000235:genetics / Q000378:metabolism*; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics / Q000378:metabolism; D009410:Nerve Degeneration / Q000502:physiology*; D009422:Nervous System Diseases / Q000235:genetics / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D010101:Oxygen Consumption; D010300:Parkinson Disease / Q000235:genetics / Q000378:metabolism
D004272:DNA, Mitochondrial; D016660:NAD(P)H Dehydrogenase (Quinone)