bFGF enhances the development of the collateral circulation after acute arterial occlusion.
An adequate collateral circulation is crucial to tissue survival subsequent to proximal major arterial occlusion. The precise mechanism of collateral blood vessel development and the biochemical mediators involved in this process are unknown. To evaluate the influence of a number of agents on the development of the collateral circulation, we developed a rat model of severe hind limb ischaemia. The recovery of blood flow after acute arterial occlusion was increased by exogenous basic fibroblast growth factor and heparin, and decreased by protamine. Erucamide (cis-13-docosenamide), an angiogenic lipid, had no effect on collateral blood flow. These results indicate that basic fibroblast growth factor and heparin are potential therapeutic agents in the treatment of peripheral vascular disease.
Chleboun
J O
JO
University Department of Surgery, Repatriation General Hospital, Nedlands, Australia.
Martins
R N
RN
Mitchell
C A
CA
Chirila
T V
TV
D000818:Animals; D004883:Erucic Acids / Q000494:pharmacology*; D005121:Extremities / Q000098:blood supply; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D006493:Heparin / Q000494:pharmacology*; D007511:Ischemia / Q000503:physiopathology; D009389:Neovascularization, Pathologic; D011479:Protamines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D013997:Time Factors
D004883:Erucic Acids; D011479:Protamines; C049508:erucyl amide; D016222:Fibroblast Growth Factor 2; D006493:Heparin