Human cytotoxic T-lymphocytes specific for autologous follicular lymphoma recognize immunoglobulin in a major histocompatibility complex restricted fashion.
BACKGROUND
Previously, autologous Burkitt lymphoma-specific cytotoxic T-lymphocytes (CTL) were found to express the gamma and delta T-cell receptor and recognize tumor idiotype in a major histocompatibility complex (MHC) unrestricted fashion.


METHODS
In this study, the authors established autologous CTL lines and clones specific for a B-cell follicular lymphoma.


RESULTS
These CTL are tumor specific and inhibited by antiimmunoglobulin monoclonal antibodies, but unlike the Burkitt lymphoma-specific CTL, they are MHC restricted and express the alpha and beta T-cell receptor.


CONCLUSIONS
These studies suggest that different B-cell lymphomas can induce CTL of different phenotypes and MHC restriction.
Luna-Fineman
S
S
Department of Pediatrics, Stanford University, California 94305.
Lee
J E
JE
Wesley
P K
PK
Clayberger
C
C
Krensky
A M
AM
D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D017252:CD3 Complex / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D002450:Cell Communication; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D006801:Humans; D007167:Immunotherapy; D016393:Lymphoma, B-Cell / Q000276:immunology* / Q000628:therapy; D008224:Lymphoma, Follicular / Q000276:immunology* / Q000628:therapy; D008285:Major Histocompatibility Complex / Q000276:immunology*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000032:analysis; D012074:Remission Induction; D013602:T-Lymphocytes, Cytotoxic / Q000737:chemistry / Q000276:immunology*; D014407:Tumor Cells, Cultured
D000911:Antibodies, Monoclonal; D017252:CD3 Complex; D016827:CD8 Antigens; D016693:Receptors, Antigen, T-Cell, alpha-beta