[Acute effect of small dosages of somatostatin analogue SMS201-995 on gallbladder contractility in normal adults].
Recently, a long-acting, somatostatin analogue, SMS201-995(SMS), has been developed and extensively investigated. It has been proved to be remarkably effective in treating many diseases, including active acromegaly. We observed the effect of SMS on gallbladder contractility in normal adults using the fatty meal test. Our results show that gallbladder contractility was inhibited significantly for 6 hours after the subcutaneous injection of SMS in dosages of 50, 25, 12.5, and 5 micrograms. We conclude that it is not practical to avoid gallbladder disfunction during long-term SMS treatment by decreasing the dosages of SMS.
Zhu
X
X
PUMC Hospital, Beijing.
D000328:Adult; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging / Q000187:drug effects; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D015282:Octreotide / Q000008:administration & dosage / Q000494:pharmacology*; D014463:Ultrasonography
D015282:Octreotide