[Action of calmodulin antagonist on the proliferation and cytoskeleton of A549 lung cancer cells].
Trifluoperazine (TFP) could inhibit the proliferation of A549 lung cancer cells and human embryo lung (HEL) cells. The inhibitory effects were dose dependent. The inhibitory effects were stronger in A549 lung cancer cells than in HEL cells at the same TFP dose. Cytoskeleton in A549 lung cancer cells treated with TFP was increased as observed electron microscopically. The role of calmodulin in the proliferation and the changes in cytoskeleton of A549 lung cancer cells is discussed.
Fan
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X
Hubei Medical College, Wuhan.
D002147:Calmodulin / Q000037:antagonists & inhibitors*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003599:Cytoskeleton / Q000187:drug effects* / Q000648:ultrastructure; D004622:Embryo, Mammalian; D006801:Humans; D008168:Lung / Q000166:cytology; D008175:Lung Neoplasms / Q000473:pathology*; D014268:Trifluoperazine / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D002147:Calmodulin; D014268:Trifluoperazine