Aluminum transfer through milk in female rats intoxicated by aluminum chloride.
Female rats received an ip injection of aluminum chloride (10 mg Al/kg/d) during the first 12 d after parturition; this treatment led to a reduction in food intake associated with a reduction in body wt. Pups of the intoxicated dams showed a growth retardation after postnatal day 7. One day after treatment, the female rats intoxicated with aluminum had a considerably higher level of aluminum in milk than controls. The aluminum levels of plasma, liver, spleen, and kidneys were also significantly higher in treated female rats than controls. On the contrary, in the same tissues of pups from treated or not treated dams, no differences in aluminum levels were observed. No effect of aluminum treatment was detected on plasma silicon levels in dams and pups.
Muller
G
G
Centre des Sciences de l'Environnement, Université de Metz, France.
Hutin
M F
MF
Burnel
D
D
Lehr
P R
PR
D000535:Aluminum / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity*; D000077410:Aluminum Chloride; D017607:Aluminum Compounds; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000378:metabolism; D001692:Biological Transport; D001835:Body Weight / Q000187:drug effects; D002712:Chlorides / Q000633:toxicity*; D004435:Eating / Q000187:drug effects; D005260:Female; D007774:Lactation / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000187:drug effects; D008297:Male; D008892:Milk / Q000187:drug effects / Q000378:metabolism*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012825:Silicon / Q000097:blood; D014018:Tissue Distribution
D017607:Aluminum Compounds; D002712:Chlorides; D000077410:Aluminum Chloride; D000535:Aluminum; D012825:Silicon