Prevention of acrolein-induced bladder injury by pentosanpolysulfate.
The active metabolite of cyclophosphamide, acrolein, which is capable of damaging the transitional epithelium of the bladder, was evaluated in both in vivo and in vitro models to determine if its damaging effect could be reduced by the presence of a sulfated polysaccharide pentosampolysulfate. It was discovered that in all models pentosanpolysulfate was capable of reducing transitional cell injury due to acrolein.
Kalota
S J
SJ
University of California, San Diego Medical Center 92103.
Stein
P C
PC
Parsons
C L
CL
D000171:Acrolein / Q000009:adverse effects / Q000037:antagonists & inhibitors*; D000818:Animals; D002478:Cells, Cultured; D005260:Female; D010426:Pentosan Sulfuric Polyester / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D001745:Urinary Bladder Diseases / Q000139:chemically induced* / Q000473:pathology
D010426:Pentosan Sulfuric Polyester; D000171:Acrolein