Alloimmune thrombocytopenia: in utero treatment by high doses of intravenous gamma globulins.
The authors report successful in utero treatment by high doses of intravenous gamma globulins in a case of neonatal alloimmune thrombocytopenia. Early diagnosis allows an appropriate management: fetal blood sampling as early as 20 weeks of gestation; in case of fetal thrombocytopenia, treatment by intravenous gamma globulin (1.0 g/kg/b.w.) each week during 8 weeks or more; ultrasound screening of in utero hemorrhage, particularly intracranial hemorrhage; fetal blood sampling before delivery at term and in utero transfusion of platelet antigen negative in case of persistence of fetal thrombocytopenia.
Poulain
P
P
Institut National de Transfusion Sanguine, Paris, France.
Kaplan
C
C
Leberre
C
C
Milon
J
J
Bergeron
C
C
Grall
J Y
JY
D000328:Adult; D016824:Antigens, Human Platelet; D001792:Blood Platelets / Q000276:immunology; D001805:Blood Transfusion, Intrauterine; D005260:Female; D005312:Fetal Blood / Q000166:cytology; D005315:Fetal Diseases / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D007231:Infant, Newborn; D007275:Injections, Intravenous; D039661:Integrin beta3; D008297:Male; D008431:Maternal-Fetal Exchange / Q000276:immunology; D010976:Platelet Count; D017713:Platelet Transfusion; D011247:Pregnancy; D013921:Thrombocytopenia / Q000151:congenital / Q000175:diagnosis / Q000628:therapy*; D005719:gamma-Globulins / Q000008:administration & dosage*
D016824:Antigens, Human Platelet; C061248:ITGB3 protein, human; D039661:Integrin beta3; D005719:gamma-Globulins