Stabilization of perflubron emulsions with egg yolk phospholipid.
Egg Yolk Phospholipid(EYP) has been used extensively as the primary surfactant in parenteral fat emulsions for many years. The simplicity, functionality and physiologic tolerance of EYP has contributed greatly to its success in the intravenous emulsion arena. The mechanism of stabilization in triglyceride emulsions is well understood; however, this is not the case with perfluorocarbon emulsions. Interfacial models, as well as emulsion stability studies, have been conducted utilizing EYP of varied composition in order to derive a structure/function relationship. Our studies indicate that minor components, total unsaturation, acyl chain length and presence of charged species have significant impact on the functional properties of EYP and the subsequent stability of the emulsion product. These findings contribute to our ability to design and manipulate natural surfactants with superior properties for use in medical applications of perfluorocarbon emulsions.
Pelura
T J
TJ
Alliance Pharmaceutical Corp., San Diego, CA.
Johnson
C S
CS
Tarara
T E
TE
Weers
J G
JG
D001802:Blood Substitutes / Q000302:isolation & purification*; D004355:Drug Stability; D004655:Emulsions; D005466:Fluorocarbons / Q000302:isolation & purification*; D006842:Hydrocarbons, Brominated; D010743:Phospholipids; D013501:Surface-Active Agents
D001802:Blood Substitutes; D004655:Emulsions; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; D010743:Phospholipids; D013501:Surface-Active Agents; C003072:perflubron