Serotonin uptake inhibition: in vivo effect of sertraline in rats.
Sertraline, a potent and selective serotonin uptake inhibitor, was used to analyze the changes occurring in the serotonin system after uptake inhibition in vivo. Sertraline (11 mg/kg) lowered extracellular 5-hydroxyindolacetic acid (5-HIAA), measured in rat hippocampus by in vivo voltammetry, for about 3 h. The interaction between sertraline and drugs known to interfere with the release or uptake of serotonin (L-5-hydroxytryptophan (5-HTP), d-norfenfluramine and tianeptine) was then studied. The sertraline-induced decrease in extracellular 5-HIAA was related to the inhibition of uptake.
Manfridi
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Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Clavenna
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De Simoni
M G
MG
D015057:1-Naphthylamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D004567:Electrodes, Implanted; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D009642:Norfenfluramine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D020280:Sertraline; D013841:Thiazepines / Q000494:pharmacology
D000929:Antidepressive Agents, Tricyclic; D013841:Thiazepines; C050504:tianeptine; D009642:Norfenfluramine; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D015057:1-Naphthylamine; D006916:5-Hydroxytryptophan; D020280:Sertraline; D004298:Dopamine; D009638:Norepinephrine