[Pharmacokinetics of the interferon inducer PHL-6 and interferon synthesis in target organs under various methods of drug administration].
The pharmacokinetics of PHL-6 and interferon synthesis dynamic in the target organs (tissues) of mice were studied during its and intraperitoneal administration. In the experimental setting, there was a direct correlation between the interferon production in the murine organs with single PHL-6 and distribution of 14C PHL-6. The highest radioactivity with its oral administration was detected in the liver and intestine. Interferon was actively synthesized in the intestine, liver and serum, showing the levels of 20000, 1024-2048 and 512-1024 IU/ml, respectively. The prolonged action of the drug was in good agreement with the low PHL-6 excretion from the body. It was also shown that almost the whole radiation dose 1 (greater than 98%) was excreted with feces and urine after single and chronic administrations of uniformly labeled PHL-6 which proved important clinical drug use.
Ershov
F I
FI
Sumin
V I
VI
Saĭitkulov
A M
AM
Baram
N I
NI
Tazulakhova
E B
EB
Ismailov
A I
AI
D000284:Administration, Oral; D000818:Animals; D001921:Brain / Q000378:metabolism*; D004355:Drug Stability; D007273:Injections, Intramuscular; D007369:Interferon Inducers / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007372:Interferons / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009930:Organic Chemicals; D014781:Viscera / Q000378:metabolism*
D007369:Interferon Inducers; D009930:Organic Chemicals; C076742:PHL 6; D007372:Interferons