Processing and presentation of ovalbumin in mice genetically selected for antibody response.
Lines of mice selected for high or low antibody production to sheep red blood cells (H-I and L-I) were studied for their ability to process and present ovalbumin to a panel of 12 T-T hybridomas in two different H-2 haplotypes. When H-I and L-I spleen cells were used as antigen-presenting cells, no difference could be observed in the peptide generation by these mice compared to H-2-compatible B.10.Q and B.10.S spleen cells, respectively. Neither normal splenic L-I B-cells nor L-I thioglycolate-induced peritoneal macrophages were defective at presenting native ovalbumin, to six and eight different I-As-restricted T-T hybrids, respectively. Altogether, these results differ from previous findings which had indicated a deficiency in the processing and presentation of antigen by the low line, L-I.
Vidard
L
L
Dana-Farber Cancer Institute, Division-Lymphocyte Biology, Boston.
Rock
K L
KL
Couderc
J
J
Mouton
D
D
Benacerral
B
B
D000818:Animals; D000917:Antibody Formation / Q000235:genetics*; D000938:Antigen-Presenting Cells / Q000502:physiology*; D001402:B-Lymphocytes / Q000276:immunology; D000939:Epitopes / Q000032:analysis; D006183:H-2 Antigens / Q000235:genetics; D008264:Macrophages / Q000276:immunology; D051379:Mice; D010047:Ovalbumin / Q000276:immunology*; D013154:Spleen / Q000276:immunology
D000939:Epitopes; D006183:H-2 Antigens; D010047:Ovalbumin