title: The NM23 gene maps to human chromosome band 17q22 and shows a restriction fragment length polymorphism with BglII.
abstract: The NM23-Hl gene is a putative tumor suppressor gene that may be important in the metastasic process. Recent genetic and immunological data indicate that the NM23-Hl gene encodes a protein with nucleoside diphosphate (NDP) kinase activity. The mapping of NM23-Hl by panels of rodent-human somatic cell hybrids and in situ hybridization showed that the gene is located in human chromosome band 17q22. A two-allele polymorphism with BglII was demonstrated.
authors.affiliation: Institute of Pathological Anatomy and Histology, University of Pisa, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Varesco
authors.forename: M A
authors.initials: MA
authors.lastname: Caligo
authors.forename: P
authors.initials: P
authors.lastname: Simi
authors.forename: D M
authors.initials: DM
authors.lastname: Black
authors.forename: V
authors.initials: V
authors.lastname: Nardini
authors.forename: L
authors.initials: L
authors.lastname: Casarino
authors.forename: M
authors.initials: M
authors.lastname: Rocchi
authors.forename: G
authors.initials: G
authors.lastname: Ferrara
authors.forename: E
authors.initials: E
authors.lastname: Solomon
authors.forename: G
authors.initials: G
authors.lastname: Bevilacqua
mesh_terms: D000483:Alleles; D000818:Animals; D001426:Bacterial Proteins; D015139:Blotting, Southern; D001943:Breast Neoplasms / Q000235:genetics; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D006224:Cricetinae; D004247:DNA / Q000235:genetics; D015252:Deoxyribonucleases, Type II Site-Specific; D016147:Genes, Tumor Suppressor; D020022:Genetic Predisposition to Disease; D006801:Humans; D006822:Hybrid Cells / Q000648:ultrastructure; D020559:Monomeric GTP-Binding Proteins; D054778:NM23 Nucleoside Diphosphate Kinases; D009693:Nucleic Acid Hybridization; D009701:Nucleoside-Diphosphate Kinase; D012150:Polymorphism, Restriction Fragment Length; D011506:Proteins / Q000235:genetics; D014157:Transcription Factors
chemical_list: D001426:Bacterial Proteins; D054778:NM23 Nucleoside Diphosphate Kinases; D011506:Proteins; D014157:Transcription Factors; D004247:DNA; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase; C024404:BglII endonuclease; D015252:Deoxyribonucleases, Type II Site-Specific; D020559:Monomeric GTP-Binding Proteins