Comparison of MRI white matter changes with neuropsychologic impairment in Cockayne syndrome.
The neuropsychologic function and white matter changes observed on magnetic resonance imaging (MRI) in Cockayne syndrome were studied. MRI with T2-weighted sequences revealed periventricular hyperintensity and white matter hyperintensity in all 3 Cockayne syndrome patients examined; in contrast, 8 age-matched controls had no periventricular or white matter hyperintensity. MRI scans were graded according to the severity of periventricular or white matter hyperintensity using a scale applied to an elderly patient population. There was no difference in the severity of MRI white matter changes in these 3 Cockayne syndrome patients, 2 of whom had severe neuropsychologic functions and one a relatively milder one. There was no correlation between neuropsychologic impairment and MRI white matter changes.
Sugita
K
K
Department of Pediatrics, Chiba University School of Medicine, Japan.
Takanashi
J
J
Ishii
M
M
Niimi
H
H
D000293:Adolescent; D001921:Brain / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology; D002552:Cerebral Ventricles / Q000473:pathology; D002648:Child; D003057:Cockayne Syndrome / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009186:Myelin Sheath / Q000473:pathology; D009460:Neurologic Examination; D009483:Neuropsychological Tests