title: Cytotoxic effects of hexavalent chromium in cultured murine macrophages.
abstract: The in vitro effect of hexavalent chromium (CrVI) on mouse peritoneal macrophages was investigated. Our results demonstrate the existence of a threshold concentration of 2.5 microM of CrVI above which chromium affects the viability of macrophages in a concentration dependent manner. Morphological changes were seen with increasing concentrations of chromium. Evidence is presented that protein production (virus-induced interferon) in murine peritoneal macrophages was impaired by hexavalent chromium at low concentrations, while random migration and phagocytic activity were only affected at high concentrations of CrVI.
authors.affiliation: Institute of Medical Microbiology, University of Aarhus, Denmark.
authors.forename: M M
authors.initials: MM
authors.lastname: Christensen
authors.forename: E
authors.initials: E
authors.lastname: Ernst
authors.forename: S
authors.initials: S
authors.lastname: Ellermann-Eriksen
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002857:Chromium / Q000633:toxicity*; D007372:Interferons / Q000096:biosynthesis; D008264:Macrophages / Q000187:drug effects* / Q000648:ultrastructure; D051379:Mice; D008807:Mice, Inbred BALB C; D010587:Phagocytosis / Q000187:drug effects
chemical_list: D002857:Chromium; D007372:Interferons