Bayesian restoration of single-channel patch clamp recordings.
The technique of patch clamp recording makes possible the measurement of current flowing through a single ion channel in a cell membrane. Examination of such recordings suggests that the current is quantal in nature, alternating in a seemingly random manner between "on" and "off," but the recordings are corrupted by noise from a variety of sources. In this paper we propose and illustrate methods for restoring the underlying quantal signal from such noisy measurements. The methods use a Markov chain prior distribution for the underlying quantal process and base the restoration on the resulting posterior distribution.
Fredkin
D R
DR
Department of Physics, University of California, San Diego, La Jolla 92093.
Rice
J A
JA
D000465:Algorithms; D000818:Animals; D001699:Biometry; D018118:Chloride Channels; D007473:Ion Channels / Q000502:physiology*; D008433:Mathematics; D008565:Membrane Proteins / Q000502:physiology; D008954:Models, Biological; D009474:Neurons / Q000502:physiology; D009865:Oocytes / Q000502:physiology; D051381:Rats; D011978:Receptors, Nicotinic / Q000235:genetics / Q000502:physiology; D015222:Sodium Channels / Q000502:physiology; D013269:Stochastic Processes
D018118:Chloride Channels; D007473:Ion Channels; D008565:Membrane Proteins; D011978:Receptors, Nicotinic; D015222:Sodium Channels