Telomeric THAM-derived perfluoroalkylated surfactants for fluorocarbon emulsions.
New fluorophilic and hydrophilic, cost efficient telomeric surfactants derived from tris(hydroxymethyl)acrylaminomethane were synthesized in 2 steps in 80% yield with respect to the perfluoroalkylated telogen. They demonstrate better ability to emulsify fluorocarbons than Pluronic f-68. The biological tolerance of these new surfactants is remarkable, the perfluorohexyl derivative was tolerated at doses of 4g/kg bw after i.v. injection in mice. None of the perfluoroalkylated THAM derivatives induces hemolysis of human red blood cells at concentrations up to 200g/l in physiological solutions.
Riess
J G
JG
Laboratoire de Chimie Moléculaire, Université de Nice-Sophia Antipolis, France.
Pavia
A A
AA
Pucci
B
B
Zarif
L
L
D000818:Animals; D001802:Blood Substitutes / Q000138:chemical synthesis* / Q000633:toxicity; D004361:Drug Tolerance; D004655:Emulsions; D005466:Fluorocarbons / Q000138:chemical synthesis* / Q000633:toxicity; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D013501:Surface-Active Agents; D014325:Tromethamine
D001802:Blood Substitutes; D004655:Emulsions; D005466:Fluorocarbons; D013501:Surface-Active Agents; D014325:Tromethamine