Shared T-cell receptor gene usage in experimental allergic neuritis and encephalomyelitis.
Experimental allergic neuritis, an autoimmune disease of the peripheral nervous system, is a model for human Guillain-Barré syndrome. Experimental allergic neuritis is mediated by CD4+ T cells reactive with myelin P2 protein. We demonstrate that these T cells use the same members of T-cell receptor V gene families for both their alpha (V alpha 2) and beta (V beta 8) chains as T cells that cause experimental allergic encephalomyelitis, an autoimmune disease of the central nervous system. Furthermore, these T cells appear to be idiotypically related. Therefore, completely different T-cell lines with different antigen specificities, producing entirely different diseases, share common T-cell receptors.
Clark
L
L
Wistar Institute of Anatomy and Biology, Philadelphia, PA.
Heber-Katz
E
E
Rostami
A
A
D000595:Amino Acid Sequence; D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000235:genetics* / Q000276:immunology; D005260:Female; D005796:Genes; D006825:Hybridomas; D016219:Immunotherapy, Adoptive; D008969:Molecular Sequence Data; D004676:Myelin Basic Protein / Q000633:toxicity; D018996:Myelin P2 Protein; D009444:Neuritis, Autoimmune, Experimental / Q000235:genetics* / Q000276:immunology; D010446:Peptide Fragments / Q000633:toxicity; D051381:Rats; D011917:Rats, Inbred Lew / Q000235:genetics / Q000276:immunology; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*
D004676:Myelin Basic Protein; D018996:Myelin P2 Protein; D010446:Peptide Fragments; D016693:Receptors, Antigen, T-Cell, alpha-beta; C076290:myelin P2 peptide SP26