Arachidonate metabolites in bronchoalveolar lavage fluid from horses with and without COPD.
Arachidonate metabolites were measured in bronchoalveolar lavage fluid (BALF) from horses with (N = 4) and without (N = 7) chronic obstructive pulmonary disease (COPD). Prostaglandin (PG) D2, leukotriene (LT) B4 and LTC4 were present in highest concentrations in BALF from clinically normal horses. Concentrations of PGE2 and PGF were significantly higher in BALF from horses with COPD than in BALF from normal horses, but no differences were detected in thromboxane B2, 6-keto-PGF1 alpha, PGD2, LTB4 or LTC4.
Watson
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ED
Department of Clinical Studies, New Bolton Center, Kennett Square, PA 19348.
Sweeney
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Steensma
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D000818:Animals; D001095:Arachidonic Acids / Q000032:analysis*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry* / Q000166:cytology; D006734:Horse Diseases / Q000378:metabolism*; D006736:Horses; D007958:Leukocyte Count / Q000662:veterinary; D015289:Leukotrienes / Q000032:analysis; D008173:Lung Diseases, Obstructive / Q000378:metabolism / Q000662:veterinary*; D009504:Neutrophils; D011453:Prostaglandins / Q000032:analysis; D013929:Thromboxane B2 / Q000032:analysis
D001095:Arachidonic Acids; D015289:Leukotrienes; D011453:Prostaglandins; D013929:Thromboxane B2