Oxygent: a novel probe of tissue oxygen tension.
We have examined the 19F NMR spectrum and relaxation behavior of Oxygent (an emulsion of perfluorooctylbromide). Each of the resonances exhibits a linear relationship between spin-lattice relaxation rate and oxygen tension at constant temperature. Oxygent provides enhanced sensitivity to changes in oxygen tension compared with other emulsions used previously. We have used Oxygent to determine the oxygen tension in the liver of a mouse.
Mason
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RP
Department of Radiology, UT-Southwestern Medical Center, Dallas 75235-9058.
Shukla
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Antich
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PP
D000818:Animals; D001802:Blood Substitutes / Q000493:pharmacokinetics*; D004655:Emulsions; D005466:Fluorocarbons / Q000493:pharmacokinetics*; D006842:Hydrocarbons, Brominated; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015335:Molecular Probes; D010100:Oxygen / Q000378:metabolism*; D014018:Tissue Distribution
D001802:Blood Substitutes; D004655:Emulsions; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; D015335:Molecular Probes; C003072:perflubron; D010100:Oxygen