Generalized papular xanthomatosis in mycosis fungoides.
Xanthomas can occur in association with underlying lymphoproliferative disease, or they can result from lipid deposition in damaged or altered skin. We report a case of generalized papular xanthomas that developed in a patient with Sézary syndrome. The xanthomas were composed of foamy histiocytes that were shown by immunoperoxidase staining to be of the monocyte/macrophage lineage. Electron microscopic studies revealed lipid vacuoles, lysosomes, and myelin figures but no Birbeck granules, features that are consistent with a non-X histiocytosis. Generalized papular xanthomatosis has not been previously described in a patient with cutaneous T-cell lymphoma.
Darwin
B S
BS
Department of Medicine, Duke University Medical Center, Durham, NC 27710.
Herzberg
A J
AJ
Murray
J C
JC
Olsen
E A
EA
D000368:Aged; D005260:Female; D006644:Histiocytes / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D008854:Microscopy, Electron; D012751:Sezary Syndrome / Q000150:complications* / Q000473:pathology / Q000648:ultrastructure; D012867:Skin / Q000473:pathology / Q000648:ultrastructure; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology / Q000648:ultrastructure; D013194:Staining and Labeling / Q000379:methods; D014973:Xanthomatosis / Q000145:classification / Q000209:etiology* / Q000473:pathology