Functional role of adhesion molecules LFA-3 and ICAM-1 on cultured human epidermal Langerhans cells in antigen-specific T-cell activation.
Interaction of T-cell antigen receptors with antigen/major histocompatibility complex (MHC) molecule complexes on antigen-presenting cells (APC) leads to T-cell activation. Additional interaction between adhesion molecules on the APC and their ligands on T cells is required for optimal T-cell activation. In vitro cultured human epidermal Langerhans cells (cLC) are powerful APC that express adhesion molecules LFA-3 and ICAM-1. Both molecules on cLC serve a functional role in the generation of a T-cell response.
Teunissen
M B
MB
Department of Dermatology, University of Amsterdam, The Netherlands.
D015703:Antigens, CD / Q000502:physiology*; D018968:CD58 Antigens; D015815:Cell Adhesion Molecules / Q000502:physiology*; D000939:Epitopes / Q000276:immunology*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D007801:Langerhans Cells / Q000737:chemistry / Q000502:physiology*; D008213:Lymphocyte Activation; D008562:Membrane Glycoproteins / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology*
D015703:Antigens, CD; D018968:CD58 Antigens; D015815:Cell Adhesion Molecules; D000939:Epitopes; D008562:Membrane Glycoproteins; D018799:Intercellular Adhesion Molecule-1