The potential relevance of cytokines to ovarian physiology.
Elucidating the secrets of intraovarian intercellular communication constitutes a central area of investigation. While most attention has been directed thus far at the somatic cellular components of the ovary, the potential role(s) and relative importance of the resident ovarian white blood cell have received relatively limited attention. Efforts are currently under way to reconcile traditional ovarian physiology with observations relevant to intraovarian components of the white blood cell series. In this connection, it is important to note that unlike some gonadal compartments, the ovary does not constitute an immunologically privileged site. Thus, resident ovarian representatives of the white blood cell series can be observed at various stages of the ovarian life cycle. Current concepts suggest that regulatory cellular networks formerly viewed in immune terms now fall within the broad domain of endocrinology. Viewed in this light, resident ovarian representatives of the white blood cell series may constitute potential in situ modulators of ovarian function acting in all likelihood through the local secretion of regulatory cytokines. As the flow of information is probably multi directional, the very same cells are probably targeted for steroidal and peptidergic input in keeping with the existence of multiple autocrine and paracrine loops.
Adashi
E Y
EY
Department of Obstetrics/Gynecology, University School of Medicine, Baltimore, MD 21201.
D016207:Cytokines / Q000502:physiology*; D005260:Female; D006801:Humans; D010053:Ovary / Q000502:physiology*
D016207:Cytokines