title: [Considerations of the pathogenesis of parakeratosis variegata based on morphologic and molecular genetic findings].
abstract: We report on a 63-year-old woman who had been suffering from generalized parakeratosis variegata since she was 7 years old. Increased tightness of the skin was the only clinical symptom. On the whole integument except for the face, we found a fine network of hyper- and depigmentation and telangiectasias. The skin surface was dry and atrophic with fine lamellar scaling. Histological, immunohistological and ultrastructural findings indicated early infiltration by a cutaneous T-cell lymphoma. However, PCR analysis of the T-cell receptor gamma-chain genes revealed multiple amplification products favouring a polyclonal T-cell proliferation. In light of the clinical history over a period of 56 years, we consider parakeratosis variegata to be a benign, chronic inflammatory condition, as is confirmed by the results of PCR analysis in this patient.
authors.affiliation: Dermatologische Klinik, Ruhr-Universität Bochum im St. Josef-Hospital.
authors.forename: C
authors.initials: C
authors.lastname: Popp
authors.forename: M
authors.initials: M
authors.lastname: Bacharach-Buhles
authors.forename: W
authors.initials: W
authors.lastname: Sterry
authors.forename: H
authors.initials: H
authors.lastname: Griesser
authors.forename: P
authors.initials: P
authors.lastname: Altmeyer
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D005784:Gene Amplification / Q000235:genetics; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000235:genetics / Q000473:pathology*; D008854:Microscopy, Electron; D008875:Middle Aged; D010241:Parakeratosis / Q000235:genetics / Q000473:pathology*; D016133:Polymerase Chain Reaction; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta
vernacular_title: Uberlegungen zur Pathogenese der Parakeratosis variegata anhand morphologischer und molekulargenetischer Befunde.