title: [Morphofunctional analysis of zinc-accumulating capacity of digestive system organs].
abstract: The distribution of zinc and related changes have been studied in zinc--loaded chick pancreas, ileum and liver at the ultrastructural level by sulphide--silver method. White Leghorn chicks fed a high zinc diets (50, 500, 1000, 2000 and 4000 mgZn/kg diet) for 6 weeks, were killed at intervals; portions of their organs were fixed for light and electron microscopy; other samples were analyzed for zinc by AA spectrophotometry. A drastic increase of zinc level in chick pancreas fed 2000 mg Zn/kg diet (as ZnCl2) was associated with acinar cell degeneration. Apoptosis was the predominant form of acinar cell deletion. This study provides support for a previously proposed theory that cell injury stimulates passive zinc accumulation.
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Markov
authors.forename: N I
authors.initials: NI
authors.lastname: Berzin'
authors.forename: A R
authors.initials: AR
authors.lastname: Val'dman
mesh_terms: D000818:Animals; D017209:Apoptosis; D002645:Chickens; D006651:Histocytochemistry; D007082:Ileum / Q000033:anatomy & histology / Q000737:chemistry / Q000378:metabolism*; D008099:Liver / Q000033:anatomy & histology / Q000737:chemistry / Q000378:metabolism*; D010179:Pancreas / Q000033:anatomy & histology / Q000737:chemistry / Q000378:metabolism*; D013054:Spectrophotometry, Atomic; D015032:Zinc / Q000032:analysis / Q000378:metabolism*
chemical_list: D015032:Zinc
vernacular_title: Morfofunktsional'nyĭ analiz tsinkdeponiruiushcheĭ sposobnosti organovpishchevaritel'noĭ sistemy.