Chromosomal localization of the mouse prealbumin gene (Ttr) by in situ hybridization.
Prealbumin is a serum protein which plays an important role in plasma transport of retinol and thyroxine. The accumulation of a variant prealbumin is associated with a hereditary disorder, familial amyloidotic polyneuropathy (FAP). In situ hybridization with a mouse prealbumin gene cDNA probe was carried out in mouse fibroblasts. Analysis of 114 R-banded metaphases showed that 13% of the total grains were located on chromosome 4 and 46% of the grains on this chromosome were in the region C6-D1. Linkage and syntenic group analysis showed that the prealbumin gene (Ttr) is located between two syntenic groups on mouse chromosome 4, which corresponded to two syntenic groups present on human chromosomes 1 and 9.
Qiu
H
H
Department of Medical Genetics, Chinese Academy of Medical Sciences, Beijing.
Shimada
K
K
Cheng
Z
Z
D000818:Animals; D002478:Cells, Cultured; D015342:DNA Probes / Q000235:genetics; D017403:In Situ Hybridization; D051379:Mice; D011228:Prealbumin / Q000235:genetics*
D015342:DNA Probes; D011228:Prealbumin