[Post-intoxication hypothermia and processes of free radical lipid peroxidation in the rat brain and heart in organophosphorus cholinesterase inhibitor poisoning].
The activity of lipid peroxidation (LP) of the brain and myocardium as well as the intensity of the body hypothermia during 30 days after a single introduction of poisons at a dose < D50 were studied on the models of induced toxicosis in rats due to two organophosphorus compounds (malathion and armin). It has been established that the maximums of diene conjugates and Schiff's bases accumulation in the rat organs poisoned with malathion and the intensity of hypothermic response on days 14 and 21 after intoxication coincided. The similar elevated lipid peroxidation was associated with esophageal hypothermia on day 14 after armin administration. Therefore, because of hypothermia, the influence of organophosphorus compounds on lipids of the rat brain and heart in the post-intoxication period may include the free radical ways of their peroxidation.
Myshkin
V A
VA
Vakarina
A F
AF
Bashkatov
S A
SA
Sofronov
G A
GA
Enikeev
D A
DA
D000818:Animals; D001138:Armin / Q000506:poisoning*; D001921:Brain / Q000378:metabolism*; D002800:Cholinesterase Inhibitors / Q000506:poisoning*; D007035:Hypothermia / Q000139:chemically induced*; D015227:Lipid Peroxidation; D008294:Malathion / Q000506:poisoning*; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D002800:Cholinesterase Inhibitors; D001138:Armin; D008294:Malathion
Postintoksikatsionnaia gipotermiia i protsessy svobodnoradikal'nogo okisleniia lipidov v mozge i serdtse krys pri otravlenii fosfororganicheskimi ingibitorami kholinésteraz.