Cytogenetics of human spermatozoa: correlations with sperm morphology and age of fertile men.
Sperm chromosomes from 15 fertile men were analyzed after fusion of their spermatozoa with zona-free hamster eggs. The total proportion of abnormal metaphases as well as the proportions of aneuploidy and structural aberrations were calculated for every man and examined for linear correlations with [1] sperm morphology and [2] the age of the persons studied. A positive correlation between the cytogenetic parameters and the percentage of abnormal sperm morphology was not evident, suggesting that assessment of sperm morphology cannot be used as an indicator of chromosomal damage in human spermatozoa. In contrast, there was a more distinct positive correlation between the age of donors and the three cytogenetic parameters studied.
Rosenbusch
B
B
Department of Gynecology and Obstetrics, University of Ulm, Germany.
Strehler
E
E
Sterzik
K
K
D000328:Adult; D000375:Aging; D000782:Aneuploidy; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013094:Spermatozoa / Q000002:abnormalities* / Q000648:ultrastructure*