[Effects of alpha-interferon on the level of adenosine metabolism enzymes and bactericidal activity of macrophages in staphylococcal infection].
In staphylococcal infection the changes in functional ability of macrophages occur: their oxygen-depending bactericidity and adenosine-desaminase activity are depressed 5-nucleotidase ability increases. Introduction of homologous alpha-IFN in the dose of 1 x 10(3) u/mouse leads to enhancing macrophage bactericidity of the animals infected, inhibits their 5-nucleotidase activity and enhances adenosine desaminase one. Influence of alpha-IFN on the activity of adenosine metabolism enzymes in macrophages can be considered one of the most important mechanisms of its modulating effect in bacterial infections.
Lazarenko
L N
LN
Spivak
N Ia
NIa
Umanskiĭ
V Iu
VIu
Vikhot'
N E
NE
Ivanenko
V K
VK
D015720:5'-Nucleotidase / Q000378:metabolism*; D000243:Adenosine Deaminase / Q000378:metabolism*; D000818:Animals; D001770:Blood Bactericidal Activity; D002478:Cells, Cultured; D016898:Interferon-alpha / Q000494:pharmacology*; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D008808:Mice, Inbred CBA; D013203:Staphylococcal Infections / Q000378:metabolism*; D013997:Time Factors
D016898:Interferon-alpha; D015720:5'-Nucleotidase; D000243:Adenosine Deaminase
Vliianie alfa-interferona na uroven' fermentov obmena adenozina i bakteritsidnuiu aktivnost' makrofagov pri stafilokokkovoĭ infektsii.