Histo- and immuno-pathological and electron microscopy studies of the splenic red pulps of schistosomiasis mansoni patients.
The histo- and immuno-pathological and electron microscopy (EM.) of the splenic red pulps studies were carried out for schistosomiasis mansoni patients and normal controls. The main pathological processes were interstitial haemorrhages, congestion, proliferation and hyperplasia of the red pulps of the schistosomiasis mansoni patients. The IgG showed marked reaction, moderate with IgA and mild with IgM. The E.M. showed an increase in the size of the different types of the reticular cells particularly those of the nuclear membrane with type II, nuclear degeneration, deposition of fibrin threads, marked fibrosis and phagocytosis and formation of pores at the sinusoidal basement membrane. It was concluded that these pathological processes and the alteration in the immunoregulatory system of the spleen of schistosomiasis mansoni patients reflect the role played and perpetrated in the development of splenomegaly.
Khalil
O M
OM
Department of Surgery, Faculty of Medicine, Zagazig University, Egypt.
Mangoud
A M
AM
Emara
M W
MW
el Feky
H M
HM
el Ashtokhy
M
M
Hamdi
K N
KN
Arafa
M A
MA
Morsy
T A
TA
D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D012555:Schistosomiasis mansoni / Q000473:pathology*; D013154:Spleen / Q000473:pathology* / Q000648:ultrastructure; D013163:Splenomegaly / Q000209:etiology