Strategies for constructing a guinea pig organ of Corti cDNA library and its potential use.
Mutations of genes common to several tissues or organs can lead to cellular damage, which may result in hearing impairment as part of a syndromic disorder. Mutations of genes that are unique to the organ of Corti would have a high probability of causing nonsyndromic hearing impairment. It is expected that such genes are involved in auditory transduction as well as in maintaining specific hair cell and supporting cell functions in the organ of Corti. Cloning and describing genes involved with nonsyndromic hearing impairment thus require the construction of a guinea pig cDNA library of the organ of Corti.
Wilcox
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National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland.
D000595:Amino Acid Sequence; D000818:Animals; D004247:DNA / Q000235:genetics*; D004926:Escherichia coli; D005784:Gene Amplification; D015723:Gene Library; D006168:Guinea Pigs; D006311:Hearing Disorders / Q000235:genetics; D009154:Mutation; D009925:Organ of Corti; D012333:RNA, Messenger / Q000235:genetics
D012333:RNA, Messenger; D004247:DNA