Postoperative elevation of serum transaminases following isoflurane anesthesia.
Halogenated inhalational anesthetics have been implicated in hepatotoxicity. Halothane hepatitis results from the biotransformation of the drug to a metabolite that binds to liver proteins, which creates a hapten, which, in turn, causes an immunologic response in the liver. Case reports of hepatic injury resulting from isoflurane, which has a decreased biotransformation compared with that of halothane, have received much criticism. We describe a patient who had elevated liver enzymes and a positive trifluoroacetyl antibody titer following an anesthetic regimen that included isoflurane.
Gunza
J T
JT
Department of Anesthesiology, University of Florida College of Medicine, Gainesville.
Pashayan
A G
AG
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood*; D000762:Anesthesia Recovery Period; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D000777:Anesthetics; D001279:Atracurium; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000209:etiology*; D005260:Female; D006801:Humans; D007530:Isoflurane / Q000009:adverse effects*; D017409:Sufentanil; D013874:Thiopental
D000777:Anesthetics; D001279:Atracurium; D017409:Sufentanil; D007530:Isoflurane; D000410:Alanine Transaminase; D013874:Thiopental