Anticholinergic influences of biperidene on the EEG effects of haloperidol.
15 normal volunteers demonstrated after 14 days of haloperidol (HA) medication (3 mg/day) a higher mean power density (mpd) in all frequency bands of the EEG power spectra combined with a higher theta and a lower alpha center frequency (cf). After further 7 days of HA medication together with the additionally applied anticholinergic biperidene (BI) (6 mg/day) the HA effects were antagonized especially in the theta cf and the alpha mpd. The higher delta and theta mpd were not antagonized. The EEG spectra of the pre- and posttreatment condition did not differ. There was a significant effect of HA on the "Adjective Mood Scale" and on the "Complaint List", which disappeared during the additional BI medication. The reaction times were prolonged with HA and decreased with BI. Blocked dopaminergic impulses on the cholinergic EEG mechanisms possibly produce higher amplitudes during HA medication. Schizophrenic patients treated with neuroleptic drugs showed similar EEG spectra in previous studies during rest but not during motor activation.
Westphal
K P
KP
Section Neurophysiology, University of Ulm, Germany.
Grözinger
B
B
Reess
J
J
Leibing
U
U
Kornhuber
A W
AW
Diekmann
V
V
Kornhuber
H H
HH
D000328:Adult; D001712:Biperiden / Q000494:pharmacology*; D004569:Electroencephalography / Q000187:drug effects*; D006220:Haloperidol / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010275:Parasympathetic Nervous System / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects
D001712:Biperiden; D006220:Haloperidol