title: Malignant tumors of the anterior cranial skull base.
abstract: Malignant tumors of the anterior cranial skull base are still a challenge for radical surgical treatment. Several different techniques and approaches have been developed over the years and the results, with mortality rates over 50%, are still not encouraging. Here we present our results of an interdisciplinary, one-stage, neurohino transfronto-transbasal surgical approach in twelve patients with such tumors. The long-term survival rate in our patients is now 83% with a mean postoperative follow-up of 19.3 months. Two patients died due to early recurrencies and metastasis after 10 and 13 months after initial treatment and postoperative irradiation. Another five patients with a follow-up of 34.2 months have had tumor recurrencies diagnosed at 19.5 months postoperatively. These patients have survived their recurrent tumor for 14.7 months. Five patients, 41% of the whole group, have been living without evidence of tumor recurrence for between 2 and 35 months.
authors.affiliation: Neurosurgical Clinic, University Clinic Erlangen-Nürnberg, Fed. Rep. of Germany.
authors.forename: U
authors.initials: U
authors.lastname: Neubauer
authors.forename: R
authors.initials: R
authors.lastname: Fahlbusch
authors.forename: M E
authors.initials: ME
authors.lastname: Wigand
authors.forename: M
authors.initials: M
authors.lastname: Weidenbecher
mesh_terms: D000328:Adult; D000368:Aged; D002648:Child; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D003399:Craniotomy / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D009669:Nose Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D010255:Paranasal Sinus Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D011183:Postoperative Complications / Q000401:mortality; D015996:Survival Rate; D014057:Tomography, X-Ray Computed