title: Linkage heterogeneity between the C3 and LDLR and the APOA4 and APOA1 loci in baboons.
abstract: We detected linkage in baboons between loci for the third component of complement (C3) and the low-density lipoprotein receptor (LDLR), lod score = 5.53, and loci for apolipoprotein A1 (APOA1) and apolipoprotein AIV (APOA4), lod score = 14.59. We also found evidence for linkage heterogeneity among the baboon pedigrees between LDLR and C3 (P = 0.04) and between APOA1 and APOA4 (P = 0.01).
authors.affiliation: Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78228-0147.
authors.forename: C M
authors.initials: CM
authors.lastname: Kammerer
authors.forename: J E
authors.initials: JE
authors.lastname: Hixson
authors.forename: M J
authors.initials: MJ
authors.lastname: Aivaliotis
authors.forename: P A
authors.initials: PA
authors.lastname: Porter
authors.forename: J L
authors.initials: JL
authors.lastname: VandeBerg
mesh_terms: D000818:Animals; D016632:Apolipoprotein A-I / Q000235:genetics*; D001054:Apolipoproteins A / Q000235:genetics*; D003176:Complement C3 / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D008126:Lod Score; D008297:Male; D010215:Papio / Q000235:genetics*; D011973:Receptors, LDL / Q000235:genetics*; D011995:Recombination, Genetic
chemical_list: D016632:Apolipoprotein A-I; D001054:Apolipoproteins A; D003176:Complement C3; D005819:Genetic Markers; D011973:Receptors, LDL; C022205:apolipoprotein A-IV