title: Effect of intraarticular glycosaminoglycan polysulfate treatment on patellofemoral pain syndrome. A prospective, randomized double-blind trial comparing glycosaminoglycan polysulfate with placebo and quadriceps muscle exercises.
abstract: OBJECTIVE
  To compare the effects of intraarticular (IA) injections of glycosaminoglycan polysulfate (GAGPS) plus basic conservative treatment with the effects of placebo injections plus conservative treatment and with the effects of conservative treatment alone in patients with chronic patellofemoral pain syndrome (PFPS).
  
  
  METHODS
  We treated 53 patients who presented with chronic PFPS in 1 knee, according to 1 of the 3 protocols, in a prospective, randomized, double-blind study. Basic conservative treatment consisted of a 6-week program of quadriceps muscle exercise, elimination of symptom-producing activities, and oral doses of nonsteroidal antiinflammatory drugs. Physiologic saline served as placebo for injection. During the 6-week treatment period, 5 injections were given 1 week apart. Along with measurements of quadriceps strength, standardized subjective, functional, and clinical assessments were performed at presentation, after 6 weeks of treatment, and after 6 months.
  
  
  RESULTS
  Results at 6 months indicated that IA injections of GAGPS or saline did not result in significant improvement beyond the good results achieved by the basic conservative treatment alone. More than two-thirds of the patients in each group experienced complete recovery.
  
  
  CONCLUSIONS
  Neither the GAGPS injections nor the physiologic saline injections are more effective than conservative therapy in the treatment of chronic PFPS. Restoration of normal quadriceps muscle function to the affected knee seems to be crucial in treating PFPS.
authors.affiliation: Tampere Research Station of Sports Medicine, UKK Institute for Health Promotion Research, Finland.
authors.forename: P
authors.initials: P
authors.lastname: Kannus
authors.forename: A
authors.initials: A
authors.lastname: Natri
authors.forename: S
authors.initials: S
authors.lastname: Niittymäki
authors.forename: M
authors.initials: M
authors.lastname: Järvinen
mesh_terms: D000293:Adolescent; D000328:Adult; D016009:Chi-Square Distribution; D002908:Chronic Disease; D003131:Combined Modality Therapy; D004311:Double-Blind Method; D005081:Exercise Therapy; D005260:Female; D006025:Glycosaminoglycans / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007270:Injections, Intra-Articular; D007592:Joint Diseases / Q000188:drug therapy / Q000628:therapy; D007719:Knee Joint; D007866:Leg; D008297:Male; D009132:Muscles; D010146:Pain / Q000188:drug therapy*; D059408:Pain Management; D011446:Prospective Studies; D013577:Syndrome
chemical_list: D006025:Glycosaminoglycans; C013786:A73025