title: Fragmentation hemolysis in a patient with hypertrophic obstructive cardiomyopathy and mitral valve prolapse.
abstract: We encountered a 65-year-old female with hypertrophic obstructive cardiomyopathy and mitral valve prolapse who had infective endocarditis and hemolytic anemia. The infecting organism of endocarditis was group A streptococci. With regard to the etiology of the hemolytic anemia, fragmentation hemolysis was considered because fragmented red cells and elevated lactic dehydrogenase were observed. Haptoglobin was markedly decreased. Coombs' test, Ham's test and abnormal hemoglobin were negative. She had not had a hemolytic attack in the past. Ultrasonic cardiography showed asymmetrical septal hypertrophy, mitral valve prolapse and 285 mmHg of calculated pressure gradient in the left ventricle. Cardiac catheterization showed 115 mmHg of left intraventricular pressure gradient and mitral regurgitation (grade 2). Hemolysis was slightly improved after treatment with propranolol. Thus, fragmentation of the normal red cells seemed to be due to shear stress.
authors.affiliation: Department of Internal Medicine, Nippon Steel Corporation Muroran Works Hospital, Muroran, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Maeda
authors.forename: T
authors.initials: T
authors.lastname: Ashie
authors.forename: K
authors.initials: K
authors.lastname: Kikuiri
authors.forename: S
authors.initials: S
authors.lastname: Fukuyama
authors.forename: Y
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: E
authors.initials: E
authors.lastname: Yoshida
authors.forename: K
authors.initials: K
authors.lastname: Shimamoto
authors.forename: O
authors.initials: O
authors.lastname: Iimura
mesh_terms: D000368:Aged; D000743:Anemia, Hemolytic / Q000188:drug therapy / Q000209:etiology; D002312:Cardiomyopathy, Hypertrophic / Q000097:blood* / Q000150:complications; D005260:Female; D006461:Hemolysis; D006801:Humans; D008945:Mitral Valve Prolapse / Q000097:blood* / Q000150:complications; D011433:Propranolol / Q000627:therapeutic use
chemical_list: D011433:Propranolol