Non-enzymatic glycosylation of myosin: effects of diabetes and ageing.
The influence of diabetes mellitus, streptozotocin-induced diabetes and ageing on the non-enzymatic glycosylation of myosin from cardiac and skeletal muscles was investigated. In cardiac muscle, and to a lesser extent also in skeletal muscles of the rat, non-enzymatic glycosylation of myosin increases with the age, as measured in 6-, 12- and 29-month-old animals. Skeletal muscle myosin from diabetic humans and also that from diabetic rat cardiac muscle are more glycosylated when compared with control myosin preparations. Ca(2+)-ATPase activity of myosin is lower in muscles of diabetic individuals as compared with control muscles.
Syrový
I
I
Institute of Physiology, Czechoslovak Academy of Sciences, Prague.
Hodný
Z
Z
D000368:Aged; D000375:Aging / Q000378:metabolism*; D000818:Animals; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006031:Glycosylation; D006321:Heart / Q000254:growth & development; D006801:Humans; D024510:Muscle Development; D009132:Muscles / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D009218:Myosins / Q000032:analysis / Q000378:metabolism*; D051381:Rats
D009218:Myosins; D000252:Calcium-Transporting ATPases