[Effects of taurine and dipeptide Tyr-Tyr on ventricular defibrillation].
Results of the study of taurine and dipeptide Tyr-Tyr effect on the threshold values of functional lesions of the myocardium and heart defibrillation are reported. The experiments were carried out on 27 narcotized mongrel dogs weighing 12-30 kg. Defibrillation was performed using Lifepak-7 defibrillator (USA). Lesion threshold (LT), defibrillation threshold (DT) and electrotherapeutic index (ETI) as a LT:DT ratio were determined. In 14 experiments (control group) these parameters were evaluated during 3 h. In group 1 (6 experiments) taurine (100 mg/kg) was infused intravenously by the end of the 1st hour, in group 2--Tyr-Tyr (25 mg/kg). It was shown that infusion of taurine did not have a noticeable effect of the LT, DT and ETI values. Infusion of Tyr-Tyr resulted in an increase in LT and DT. The possibility to use dipeptide Tyr-Tyr in the complex of measures aimed at ceasing ventricular fibrillation is discussed.
Ivanov
G G
GG
Vostrikov
V A
VA
Bogushevich
M S
MS
Medvedev
O S
OS
Bespalova
Zh D
ZhD
D000818:Animals; D004151:Dipeptides / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D004554:Electric Countershock; D006321:Heart / Q000187:drug effects*; D007262:Infusions, Intravenous; D013654:Taurine / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors; D014443:Tyrosine
D004151:Dipeptides; D013654:Taurine; D014443:Tyrosine
Vliianie taurina i dipeptida Tyr-Tyr na defibrilliatsiiu zheludochkov serdtsa.