Neutron-capture therapy of murine ascites tumor with gadolinium-containing microcapsules.
Gadolinium-containing microcapsules were evaluated as an agent for gadolinium neutron-capture therapy. Mice were inoculated intraperitoneally with 10(7) Ehrlich ascites tumor cells and gadolinium microcapsules and exposed to thermal neutrons for 12 min (approximately 1.86 x 10(12) neutrons cm-2). Significantly more mice given gadolinium microcapsules than those given placebo microcapsules or control survived for 60 days and considerably longer (P < 0.0001), indicating that gadolinium neutron-capture reactions effectively suppressed the growth of ascites tumor cells in mice. The results suggest that these microcapsules are an effective gadolinium carrier for neutron-capture therapy.
Akine
Y
Y
Outpatient Clinic, National Cancer Center Hospital, Tokyo, Japan.
Tokita
N
N
Tokuuye
K
K
Satoh
M
M
Fukumori
Y
Y
Tokumitsu
H
H
Kanamori
R
R
Kobayashi
T
T
Kanda
K
K
D000818:Animals; D002214:Capsules; D002286:Carcinoma, Ehrlich Tumor / Q000532:radiotherapy*; D005682:Gadolinium / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D017247:Neutron Capture Therapy
D002214:Capsules; D005682:Gadolinium