title: [Perforating keratoplasty in endogenous eczema. An indication for systemic cyclosporin A--a retrospective study of 18 patients].
abstract: Endogenous eczema represents a considerable risk for perforating keratoplasty because of the associated chronic surface disorders and complex immunological disturbances. Between December 1986 through October 1991 we performed 24 perforating keratoplasties in 20 eyes of 18 patients with endogenous eczema suffering from keratokonus, atopic keratokonjunctivitis and bullous keratopathy after intracapsular cataract extraction. During the follow-up period of 16 (3-48) months 6 transplants failed mostly due to surface problems as well as immune reactions and bacterial transplant infections. Systemically administered ciclosporin A was found to eliminate many of the previously unsolved problems. In summary, 18 out of 20 eyes achieved an improved visual acuity with clear transplants.
authors.affiliation: Augenklinik, Heinrich-Heine-Universität Düsseldorf.
authors.forename: T
authors.initials: T
authors.lastname: Reinhard
authors.forename: R
authors.initials: R
authors.lastname: Sundmacher
mesh_terms: D000328:Adult; D000368:Aged; D001762:Blepharitis / Q000188:drug therapy*; D016572:Cyclosporine / Q000627:therapeutic use*; D003876:Dermatitis, Atopic / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007637:Keratoconjunctivitis / Q000188:drug therapy*; D007640:Keratoconus / Q000601:surgery; D015948:Keratoplasty, Penetrating; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy*; D012189:Retrospective Studies; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D016572:Cyclosporine
vernacular_title: Perforierende Keratoplastik bei endogenem Ekzem. Eine Indikation für systemisches Ciclosporin A--eine retrospektive Studie über 18 Patienten.