[The reproduction of reassortant influenza A and B viruses with a known genome composition in different cell systems].
Reproduction of parental strains and reassortants (with known genome composition) of influenza A and B viruses was studied in chick embryos (CE) and in different cell lines (SPEV, MDCK, BHK-21, M22, etc.). The results agree with the concept that the yield of influenza A virus in CE depends on its M-gene. At the same time, the experimental results suggest that reproduction of influenza B virus in the same system is not determined by M-gene. Reproduction (hr-phenotype) of influenza A and B viruses in cell cultures was shown to be determined not only by the gene coding for hemagglutinin but also by other virus genes, the reproduction level being dependent on different genes in different cell systems.
Klimov
A I
AI
Podcherniaeva
R Ia
RIa
Danlybaeva
G A
GA
Iaros
V V
VV
Lisovskaia
K V
KV
D000818:Animals; D002460:Cell Line; D016679:Genome, Viral; D006801:Humans; D009980:Influenza A virus / Q000235:genetics / Q000502:physiology*; D009981:Influenza B virus / Q000235:genetics / Q000502:physiology*; D016865:Reassortant Viruses / Q000235:genetics / Q000502:physiology*; D014776:Virus Cultivation; D014779:Virus Replication / Q000235:genetics / Q000502:physiology*
Reproduktsiia reassortantov virusov grippa A i B s izvestnym sostavom genoma v razlichnykh kletochnykh sistemakh.