Analysis of vancomycin time-kill studies with Staphylococcus species by using a curve stripping program to describe the relationship between concentration and pharmacodynamic response.
Mono- and biexponential killing curves for vancomycin over a 2- to 50-micrograms/ml concentration range were generated for 11 Staphylococcus aureus isolates and 12 coagulase-negative Staphylococcus species in the logarithmic phase of growth. Nonlinear least-squares regression of the initial growth rate and disappearance were not significantly different for lower or higher concentrations of vancomycin in broth.
Ackerman
B H
BH
Department of Pharmacy Practice, College of Pharmacy, University of Arkansas, Little Rock 72205.
Vannier
A M
AM
Eudy
E B
EB
D003030:Coagulase / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D013210:Staphylococcus / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D013997:Time Factors; D014640:Vancomycin / Q000494:pharmacology*
D003030:Coagulase; D014640:Vancomycin