title: Thromboxane synthetase inhibition produces maternal and fetal vasodilation during ovine pregnancy-induced hypertension: a Doppler flow velocimetric study.
abstract: Changes in maternal and fetal umbilical arterial vasoreactivity during ovine pregnancy-induced hypertension and following intravenous administration of CGS 12970 [3-methyl-2-(3-pyridyl)-1-indoleoctanoic acid] were assessed. Continuous wave Doppler flow velocimetry was used to assess vascular reactivity during normotensive baseline, during ovine pregnancy-induced hypertension triggered by a 72-hour fast, and following thromboxane synthetase inhibition with CGS 12970. Uterine and umbilical arterial systolic/diastolic flow ratios increased significantly with the onset of sustained hypertension. After thromboxane synthetase inhibition, uterine and umbilical artery systolic/diastolic flow ratios were not different from baseline, and maternal blood pressure had returned to baseline values. These data indicate that thromboxane produces maternal and fetal vasoconstriction during ovine pregnancy-induced hypertension. Furthermore, these data provide strong evidence that thromboxane synthetase inhibition allows vasodilation, resulting in improved maternal and fetal condition.
authors.affiliation: Department of Biomedical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg 24061-0442.
authors.forename: J C
authors.initials: JC
authors.lastname: Keith
authors.forename: T
authors.initials: T
authors.lastname: Moskal
authors.forename: M K
authors.initials: MK
authors.lastname: Eggleston
authors.forename: C
authors.initials: C
authors.lastname: Konczal
authors.forename: T L
authors.initials: TL
authors.lastname: Howerton
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D005260:Female; D006973:Hypertension / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D011725:Pyridines / Q000494:pharmacology* / Q000627:therapeutic use; D012756:Sheep; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*; D014463:Ultrasonography; D014469:Umbilical Arteries / Q000000981:diagnostic imaging*; D014599:Uterus / Q000098:blood supply* / Q000000981:diagnostic imaging; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D011725:Pyridines; C049113:3-methyl-2-(3-pyridyl)-1-indoleoctanoic acid; D013930:Thromboxane-A Synthase