title: Late onset Leber's optic neuropathy: a case confused with ischaemic optic neuropathy.
abstract: A case is reported of a 63-year-old man with progressive central visual loss in one eye followed 11 months later by involvement of the fellow eye. A diagnosis of chronic ischaemic optic neuropathy was considered. However, despite a negative family history, the absence of electrocardiographic abnormalities, and minimal fundus changes a diagnosis of Leber's optic neuropathy was made on the basis of magnetic resonance imaging findings and the mitochondrial DNA mutation at base pair 11778.
authors.affiliation: National Hospital for Neurology and Neurosurgery, Neuro-Ophthamology Unit, Queen Square, London.
authors.forename: F X
authors.initials: FX
authors.lastname: Borruat
authors.forename: W T
authors.initials: WT
authors.lastname: Green
authors.forename: E M
authors.initials: EM
authors.lastname: Graham
authors.forename: M G
authors.initials: MG
authors.lastname: Sweeney
authors.forename: J A
authors.initials: JA
authors.lastname: Morgan-Hughes
authors.forename: M D
authors.initials: MD
authors.lastname: Sanders
mesh_terms: D004272:DNA, Mitochondrial / Q000032:analysis; D003937:Diagnosis, Differential; D005451:Fluorescein Angiography; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015418:Optic Atrophies, Hereditary / Q000175:diagnosis* / Q000235:genetics; D009896:Optic Atrophy / Q000175:diagnosis; D009900:Optic Nerve / Q000473:pathology
chemical_list: D004272:DNA, Mitochondrial