Long-term tolerance and efficacy of 3'-azidothymidine and 3'-fluorothymidine treatment of asymptomatic monkeys infected with simian immunodeficiency virus.
Macaques chronically infected with simian immunodeficiency virus were treated with zidovudine (20 mg/kg of body weight per day for 9 weeks) or 3'-fluorothymidine (5 mg/kg of body weight per day for 9 weeks or three doses of 2 mg/kg per day for 24 days). Hematological changes in the treated animals included macrocytic anemia and leukopenia. Determination of antiviral effects in this model requires improved assay methods.
Böttiger
D
D
Department of Virology, Karolinska Institute, Stockholm, Sweden.
Ståhle
L
L
Li
S L
SL
Oberg
B
B
D000740:Anemia / Q000139:chemically induced; D000818:Animals; D000998:Antiviral Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001772:Blood Cell Count; D015704:CD4 Antigens / Q000276:immunology; D015224:Dideoxynucleosides / Q000009:adverse effects / Q000627:therapeutic use*; D004798:Enzymes / Q000097:blood; D007970:Leukopenia / Q000097:blood / Q000139:chemically induced; D008252:Macaca fascicularis; D016097:Simian Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D015215:Zidovudine / Q000009:adverse effects / Q000627:therapeutic use*
D000998:Antiviral Agents; D015704:CD4 Antigens; D015224:Dideoxynucleosides; D004798:Enzymes; D015215:Zidovudine; C002854:alovudine