title: Retrospective study correlating clinical infectious history and peripheral blood T-cell subpopulations in cancer, GvH and HIV+ patients.
abstract: The CD4+ CD8- inducer helper cell and the CD4- CD8+ cytotoxic/suppressor cell absolute numbers were measured in the peripheral blood of patients with various pathological conditions: with leukemia-lymphomas or solid tumors, patients with bone marrow grafts suffering from GvH, HIV-1 asymptomatic carriers, ARC and AIDS patients. The study was carried out during observation periods when they were not suffering from opportunistic infections and were untreated. In all the groups a decrease of the CD4+ CD8- cell absolute number was observed. In the leukemia-lymphoma and solid tumor bearing patients the CD4- CD8+ absolute value was lower than normal, while in the GvH- and HIV-infected patients, it was significantly higher. The clinical follow-up of each group indicates that GvH, ARC and AIDS patients developed infection in 40-68% of the cases, ie the only groups at risk of infection are those in which the CD4- CD8+ absolute values are high: we suggest that the balance CD4+ versus CD8+ should be considered rather the absolute CD4+ when discussing appropriate use of immuno-regulators.
authors.affiliation: Institut du Cancer et d'Immunogénétique (CNRS and Association Claude Bernard), Villejuif, France.
authors.forename: G
authors.initials: G
authors.lastname: Mathé
authors.forename: P
authors.initials: P
authors.lastname: Meyer
authors.forename: S
authors.initials: S
authors.lastname: Brienza
authors.forename: M
authors.initials: M
authors.lastname: Gil-Delgado
authors.forename: S
authors.initials: S
authors.lastname: Orbach-Arbouys
authors.forename: M
authors.initials: M
authors.lastname: Itzhaki
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology*; D016516:CD4-CD8 Ratio; D006086:Graft vs Host Disease / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D006679:HIV Seropositivity / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D009369:Neoplasms / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D012189:Retrospective Studies