[Pathomorphology of experimental Candida mycosis].
An account is given in this paper of evaluated results obtained from over 30 years of research on the pathogenesis and morphology of experimental candidiasis. No success has so far been recorded from efforts to set up a fully valid animal experimental model of all forms of candidiasis in man. Models so far can be successfully constructed only for certain links in the process of infection. Particular importance, in this context, should be attributed to effects on the organism which would cause improvement or reduction of specific and unspecific resistance. Critical analysis of results obtained from differently conceptualized experiments has contributed to comprehensive understanding of the morphogenesis of opportunistic candida infections in man. Models established in the wake of animal experiments have provided a basis for formulation of principles of a combined candidiasis therapy, using both antibiotics and immunomodulators.
Chmelnizkij
O K
OK
Lehrstuhl für Pathologische Anatomie, Instituts für Arztliche Fortbildung St. Petersburg, Russland.
Beljanin
V L
VL
D000818:Animals; D002177:Candidiasis / Q000473:pathology*; D004195:Disease Models, Animal; D008168:Lung / Q000382:microbiology / Q000473:pathology; D051379:Mice
Die pathomorphologie experimenteller Kandidosen.