[Acyl and plasmalogen analogs of platelet activating factor--new lipid cellular bioregulators].
Recent data concerning two structural platelet-activating factor (PAF) analogs-1-O-acyl-2-acetyl-sn-glycero-3-phosphocholine (acyl-PAF) and 1-O-alk-1'-enyl-2-acetyl-sn-glycero-3-phosphocholine (vinyl-PAF) identified in some cells and tissues are reviewed. Isolation, identification, biosynthesis, and metabolism of acyl-PAF and vinyl-PAF are considered. The activity of acyl-PAF and vinyl-PAF towards platelets, leukocytes, isolated myocardium, and ileum as well as its in vivo activity are discussed. The influence of acyl-PAF and vinyl-PAF on PAF platelet interaction, Ca2+ mobilization, and platelet adenylate cyclase activity is considered. It is concluded that similar to PAF, acyl-PAF and vinyl-PAF should be regarded as a family of PAF lipid bioregulators.
Kulikov
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Muzia
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D000215:Acylation; D066298:In Vitro Techniques; D008055:Lipids / Q000502:physiology*; D010713:Phosphatidylcholines / Q000502:physiology*; D010955:Plasmalogens / Q000737:chemistry*; D010972:Platelet Activating Factor / Q000031:analogs & derivatives* / Q000502:physiology
C069030:1-acyl-2-acetyl-sn-glycero-3-phosphocholine; D008055:Lipids; D010713:Phosphatidylcholines; D010955:Plasmalogens; D010972:Platelet Activating Factor
Atsil'nyĭ plazmalogennyĭ analogi faktora aktivatsii trombotsitov-- novye lipidnye kletochnye bioreguliatory.