Mechanisms in intimal monocyte-macrophage recruitment. A special role for monocyte chemotactic protein-1.
This article briefly addresses the role of the monocyte-macrophage in atherogenesis and the potential mechanisms participating in intimal blood monocyte recruitment. The obligatory components of the recruitment process, i.e., contact with the vascular endothelium, attachment, and migration into the subendothelial space, are addressed with reference to the influence of blood flow, plasma proteins (particularly low density lipoprotein), and inflammatory mediators and cytokines. The potentially important role of monocyte chemotactic protein-1 in regulating monocyte recruitment in plaque pathogenesis is discussed.
Valente
A J
AJ
Department of Pathology, Graduate School of Biomedical Sciences, University of Texas Health Science Center, San Antonio 78284-7750.
Rozek
M M
MM
Sprague
E A
EA
Schwartz
C J
CJ
D001161:Arteriosclerosis / Q000378:metabolism / Q000473:pathology*; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000502:physiology; D002465:Cell Movement; D018932:Chemokine CCL2; D002630:Chemotactic Factors / Q000378:metabolism / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology; D006801:Humans; D008264:Macrophages / Q000502:physiology*; D009000:Monocytes / Q000502:physiology*
D015815:Cell Adhesion Molecules; D018932:Chemokine CCL2; D002630:Chemotactic Factors