An immunodominant haptenic epitope of carbamazepine detected in serum from patients given long-term treatment with carbamazepine without allergic reaction.
An anticarbamazepine antibody was detected in the serum of a patient with severe carbamazepine-induced serum sickness. We found that the patient's T cells and IgG antibody recognized an epitope which appeared in subjects showing an allergic reaction, as well as that in subjects who showed no allergic reaction, after long-term carbamazepine therapy. These results show that an anti-carbamazepine immune response does not occur in the majority of subjects who undergo long-term carbamazepine therapy without developing allergic symptoms, although the immunodominant haptenic epitope of carbamazepine is present in their sera.
Igarashi
M
M
Department of Pediatrics, Kitasato University, School of Medicine, Kanagawa, Japan.
Hosoda
N
N
Bando
Y
Y
Shimanuki
K
K
Sunaoshi
W
W
Shirai
H
H
Miura
H
H
D002220:Carbamazepine / Q000009:adverse effects / Q000276:immunology*; D002648:Child; D004334:Drug Administration Schedule; D004342:Drug Hypersensitivity / Q000276:immunology*; D005260:Female; D006241:Haptens / Q000276:immunology*; D006801:Humans; D016056:Immunodominant Epitopes / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D012713:Serum Sickness / Q000209:etiology / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D006241:Haptens; D016056:Immunodominant Epitopes; D007074:Immunoglobulin G; D002220:Carbamazepine