Immunosuppression by whole-body irradiation and its effect on oedema in experimental cerebral ischaemia.
The effect of global immunosuppression by sublethal whole body X-irradiation on the development of cerebral oedema was assessed 24 h after right middle cerebral artery occlusion in the rat. Irradiation produced a significant leukopenia and thrombocytopaenia, and significantly reduced cortical oedema when compared to non-irradiated control animals.
Strachan
R D
RD
Department of Surgery (Neurosurgery), University of Newcastle-Upon-Tyne, England.
Kane
P J
PJ
Cook
S
S
Chambers
I R
IR
Clayton
C B
CB
Mendelow
A D
AD
D000818:Animals; D001792:Blood Platelets / Q000276:immunology* / Q000528:radiation effects; D001921:Brain / Q000276:immunology / Q000528:radiation effects; D001929:Brain Edema / Q000276:immunology*; D002544:Cerebral Infarction / Q000276:immunology*; D007165:Immunosuppression Therapy; D007958:Leukocyte Count / Q000528:radiation effects; D008297:Male; D009504:Neutrophils / Q000276:immunology* / Q000528:radiation effects; D010976:Platelet Count / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000276:immunology*; D051381:Rats; D017208:Rats, Wistar; D013046:Specific Gravity; D014916:Whole-Body Irradiation