title: Insulin inhibits norepinephrine overflow from peripheral sympathetic nerve ending.
abstract: The effects of insulin on peripheral nervous system are unknown. We therefore studied the effects of insulin on sympathetic nerve activity in isolated mesenteric arteries of Sprague-Dawley rats. The overflow of norepinephrine (NE) by electrical stimulation was used as the index of sympathetic nervous system activity. Insulin (0.5 to 1U/l) decreased the NE release in a dose-dependent fashion. This inhibitory effect was, however, reversed by either 5 x 10(-5)M cocaine or 5 x 10(-4)M ouabain treatment. Thus, we postulate that insulin attenuates NE overflow from peripheral sympathetic nerve endings, probably due to enhanced NE reuptake.
authors.affiliation: Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shimosawa
authors.forename: K
authors.initials: K
authors.lastname: Ando
authors.forename: A
authors.initials: A
authors.lastname: Ono
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Isshiki
authors.forename: M
authors.initials: M
authors.lastname: Kanda
authors.forename: E
authors.initials: E
authors.lastname: Ogata
authors.forename: T
authors.initials: T
authors.lastname: Fujita
mesh_terms: D000818:Animals; D003042:Cocaine / Q000494:pharmacology; D004558:Electric Stimulation; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D008638:Mesenteric Arteries / Q000294:innervation*; D009131:Muscle, Smooth, Vascular / Q000294:innervation; D009411:Nerve Endings / Q000187:drug effects* / Q000502:physiology; D009638:Norepinephrine / Q000378:metabolism* / Q000494:pharmacology; D010042:Ouabain / Q000494:pharmacology; D010477:Perfusion; D051381:Rats; D017207:Rats, Sprague-Dawley; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000502:physiology
chemical_list: D007328:Insulin; D010042:Ouabain; D003042:Cocaine; D009638:Norepinephrine