Molecular cloning and sequence analysis of a chicken ornithine decarboxylase cDNA.
A chicken embryo cDNA library was screened with a mouse probe for ornithine decarboxylase (ODC) and 14 positively hybridizing clones isolated. The longest of these (1.7 kb) was sub-cloned and sequenced. It is estimated that the clone comprises approximately 98% of the coding region for chicken ODC. The DNA sequence shows 78% identity with the human ODC cDNA sequence and the deduced amino acid sequence is almost 90% homologous to mouse and human. Both the peptide and cDNA sequences show interesting potential regulatory features which are discussed here.
Johnson
R
R
AFRC Institute of Animal Physiology and Genetics Research, Edinburgh Research Station, Roslin, Midlothian, UK.
Bulfield
G
G
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002642:Chick Embryo; D002645:Chickens / Q000235:genetics*; D003001:Cloning, Molecular; D004247:DNA; D015698:Genomic Library; D006801:Humans; D008969:Molecular Sequence Data; D009955:Ornithine Decarboxylase / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
D004247:DNA; D009955:Ornithine Decarboxylase