Immunogenicity and reactogenicity of Takeda acellular pertussis-component diphtheria-tetanus-pertussis vaccine in 2- and 3-month-old children in Japan.
OBJECTIVE
To compare the reactogenicity and immune response to the Takeda acellular pertussis-component diphtheria-tetanus-pertussis (APDT) vaccine in children when immunization commenced at 2 months (group A) vs 3 months (group B) of age.


METHODS
Longitudinal, nonblinded, comparative study.


METHODS
Pediatric well-child clinics.


METHODS
Healthy 50- to 98-day-old infants.


RESULTS
Good antibody responses to lymphocytosis-promoting factor, filamentous hemagglutinin, agglutinogens, and pertactin occurred in both age groups after both the third and fourth vaccine doses. Both young age and transplacentally acquired maternal antibody independently and together have a suppressive effect on the response to the four antigens in this APDT vaccine. However, these effects appear to be minor. Vaccine reactions were mild; group A children had slightly but not significantly higher rates than group B children.


CONCLUSIONS
The present US diphtheria and tetanus toxoids and pertussis vaccine immunization schedule should also be satisfactory with this acellular pertussis component vaccine.
Kamiya
H
H
Mie National Hospital, Tsu, Japan.
Nii
R
R
Matsuda
T
T
Yasuda
N
N
Christenson
P D
PD
Cherry
J D
JD
D000367:Age Factors; D000917:Antibody Formation; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D003875:Drug Eruptions / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D007115:Immunization Schedule; D015994:Incidence; D007223:Infant; D007564:Japan / Q000453:epidemiology; D008137:Longitudinal Studies
D015721:Diphtheria-Tetanus-Pertussis Vaccine