Review article: the pathophysiology and pharmacological treatment of portal hypertension.
The pathogenesis of portal hypertension remains poorly understood. Similarly, pharmacological manipulation for the prevention and treatment of variceal haemorrhage has not fulfilled the promise of the 1980s. This article reviews current concepts in the pathophysiology of portal hypertension and considers pharmacotherapy for the treatment of variceal bleeding.
Grose
R D
RD
Department of Medicine, Royal Infirmary, Edinburgh, UK.
Hayes
P C
PC
D000818:Animals; D006801:Humans; D006975:Hypertension, Portal / Q000188:drug therapy* / Q000503:physiopathology*