Antitubercular activity of trifluoperazine, a calmodulin antagonist.
Trifluoperazine, a calmodulin antagonist, completely inhibited the growth of mycobacteria. The minimum inhibitory concentrations in shake cultures in a synthetic medium containing 0.2% Tween 80 were 5 and 8 micrograms/ml, respectively, for the human pathogenic strain Mycobacterium tuberculosis H37Rv and M. tuberculosis resistant to isoniazid. When added to a growing culture of M. tuberculosis H37Rv on the 10th day (mid exponential phase), trifluoperazine 50 micrograms/ml further arrested growth of this organism. It is suggested that trifluoperazine or similar calmodulin antagonists might be useful as antitubercular drugs.
Ratnakar
P
P
University College of Medical Sciences, Shahdara, Delhi, India.
Murthy
P S
PS
D000995:Antitubercular Agents / Q000494:pharmacology*; D002147:Calmodulin / Q000037:antagonists & inhibitors*; D004352:Drug Resistance, Microbial; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development / Q000472:pathogenicity; D014268:Trifluoperazine / Q000008:administration & dosage / Q000494:pharmacology*
D000995:Antitubercular Agents; D002147:Calmodulin; D014268:Trifluoperazine