[The effect of indomethacin and leukinferon on the level of blood plasma thromboxane B2, platelet aggregation and the immune system of patients with endometrial cancer in the perioperative period].
The perioperative influence of leukinferon, indomethacin and their combination on the blood plasma level of thromboxane B2 (TxB2), platelet aggregation ability and humoral and cellular immunity has been assessed in 40 endometrial cancer patients. It has been found that the perioperative use of indomethacin diminishes the blood plasma level of TxB2 and platelet aggregation ability. Leukinferon did not affect substantially the parameters. However, the combination of leukinferon with indomethacin causes a more stable reduction in platelet aggregation and TxB2 level than the use of indomethacin alone. The use of these drugs and their combination prevented postoperative immune suppression in the endometrial cancer patients. However, leukinferon alone or its combination with indomethacin were more effective than the use of indomethacin alone. Possible mechanisms of indomethacin and leukinferon effect on tumor cell metabolism of arachidonic acid and possible role of eicosanoids in the pathogenetic mechanisms of tumor growth and metastasis dissemination are discussed.
Mistakopulo
N F
NF
Shoshiashvili
V D
VD
Saltanov
A I
AI
Kushlinskiĭ
N E
NE
Ivshina
A V
AV
Madzhuga
A I
AI
Liakina
L T
LT
Ukrainets
A M
AM
Zabotina
T N
TN
Kadagidze
Z G
ZG
D016207:Cytokines / Q000494:pharmacology*; D004338:Drug Combinations; D016889:Endometrial Neoplasms / Q000601:surgery*; D005260:Female; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology*; D007370:Interferon Type I / Q000494:pharmacology*; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D013929:Thromboxane B2 / Q000097:blood*
D016207:Cytokines; D004338:Drug Combinations; D007370:Interferon Type I; D010975:Platelet Aggregation Inhibitors; C062252:leukinferon; D013929:Thromboxane B2; D007213:Indomethacin
Vliianie indometatsina i leĭkinferona na uroven' tromboksana B2 v plasme krovi, agregatsiiu trombotsitov i immunnuiu sistemy bol'nykh rakom eńdometriia v perioperatsionnom periode.