title: [The physicochemical characterization and therapeutic evaluation of Cicatrol].
abstract: Cicatrol ointment with the formula: argentic sulphamethoxydiasine 1 g, bentonite hydrogel 12.5% for 100 g is manufactured at the Microproduction Laboratory of the Faculty of Pharmacy of Iaşi. The one-year physicochemical determinations of the aspect, colour, homogeneity, pH, rheological behaviour and relative viscosity, content in argentic sulphamethoxydiasine as well as "in vitro" antimicrobial activity of Cicatrol showed a good stability and gel properties enabling an uniform and long-term contact with the wound. The clinical investigations carried out until now in patients with burns, varicose ulcers, trophic shank ulcers, superficial phlebitis with atonic ulcerations or wounds with multiple sites revealed its remarkable therapeutic value. As compared to other similar products, Cicatrol by its aseptic properties favours the scarring of any type of wound, a normal skin, without keloid scars being obtained, it also being well tolerated.
authors.affiliation: Facultatea de Farmacie Iaşi.
authors.forename: I
authors.initials: I
authors.lastname: Popovici
authors.forename: G
authors.initials: G
authors.lastname: Dănila
authors.forename: N
authors.initials: N
authors.lastname: Oiţă
authors.forename: F
authors.initials: F
authors.lastname: Dima
authors.forename: M
authors.initials: M
authors.lastname: Vasilescu
authors.forename: V
authors.initials: V
authors.lastname: Dorneanu
authors.forename: D
authors.initials: D
authors.lastname: Lazăr
authors.forename: C
authors.initials: C
authors.lastname: Caraman
authors.forename: S
authors.initials: S
authors.lastname: Braha
authors.forename: A T
authors.initials: AT
authors.lastname: Popovici
mesh_terms: D002056:Burns / Q000188:drug therapy; D002266:Carboxymethylcellulose Sodium; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004338:Drug Combinations; D004341:Drug Evaluation; D004355:Drug Stability; D005990:Glycerol; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007871:Leg Ulcer / Q000188:drug therapy; D008826:Microbial Sensitivity Tests; D009824:Ointments; D010205:Pantothenic Acid / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D018030:Silver Compounds; D013417:Sulfameter / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D014647:Varicose Ulcer / Q000188:drug therapy; D014783:Viscosity
chemical_list: D004338:Drug Combinations; D009824:Ointments; D018030:Silver Compounds; C050071:calcium pantothenate, carboxymethylcellulose, glycerin, silver sulfameter, xylene drug combination; D010205:Pantothenic Acid; D013417:Sulfameter; D002266:Carboxymethylcellulose Sodium; D005990:Glycerol
vernacular_title: Caracterizarea fizico-chimică şi evaluarea terapeutică a produsului Cicatrol.