[Flavobion and thioctacid lessen irradiation-induced latent injury of the liver].
The effect of hepatoprotective drugs (flavobion and thioctacid) and a single whole-body irradiation (5.7 Gy of gamma radiation) on the regeneration of rat liver was examined. Liver regeneration was estimated on the basis of chosen morphological parameters on hour 30 after partial hepatectomy. Radiation-induced latent injury to intact rat liver 30 min before partial hepatectomy manifested in remaining regenerating liver by slowing-down of the increase in liver weight, cellularity and inhibition of the mitotic activity and in more frequent chromosome aberrations. Both hepatoprotective agents, especially thioctacid, used i.p. 60 min before irradiation, i.e. 90 min before partial hepatectomy, alleviate the manifestations of latent injury in this low proliferating organ as indicated by an increase in cellularity and mitotic index as compared with unprotected animals. Furthermore, the preparations tested decreased the frequency of radiation-induced chromosome aberrations.
Kropachova
K
K
Mishurova
E
E
D000818:Animals; D002869:Chromosome Aberrations; D006498:Hepatectomy; D008099:Liver / Q000187:drug effects* / Q000528:radiation effects*; D008115:Liver Regeneration; D008297:Male; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D012838:Silymarin / Q000494:pharmacology*; D008063:Thioctic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D014916:Whole-Body Irradiation
D012838:Silymarin; D008063:Thioctic Acid; C013091:lipoamide
Flavobion i tioktatsid oslabliaiut latentnoe povrezhdenie pecheni krys, indutsirovannoe oblucheniem.