Vasopressin V1-antagonist increases the hydroosmotic response to arginine vasopressin in frog urinary bladder.
V1-antagonist, [Mca1, D-Phe2, Sar7] arginine vasopressin, at a concentration 0.5 nM to 5 nM increased hydroosmotic effect of 5 nM arginine vasopressin in frog urinary bladder. 1 nM V1-antagonist [Mca1, O-Me-Tyr2] arginine vasopressin does not changed hydroosmotic effect of 0.1 nM dibutyryl cAMP. We suggest that-both V1- and V2-receptors are present on epithelial cells of frog urinary bladder and that V1-receptors are involved in the modulation of the hydroosmotic effect of arginine vasopressin-mediated by V2-receptors. by V2-receptors.
Natochin YuV
Sechenov Institute of Evolutionary Physiology & Biochemistry, Sankt-Petersburg, Russian Federation.
Shakhmatova
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EI
D000818:Animals; D001127:Arginine Vasopressin / Q000037:antagonists & inhibitors / Q000502:physiology*; D008297:Male; D011896:Rana temporaria; D017483:Receptors, Vasopressin / Q000502:physiology*; D001743:Urinary Bladder / Q000502:physiology*; D014882:Water-Electrolyte Balance / Q000502:physiology*
D017483:Receptors, Vasopressin; D001127:Arginine Vasopressin