The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species.
A mouse myotube-derived cDNA encoding the Ca(2+)-dependent cell adhesion molecule M-cadherin was used to study the segregation of the corresponding gene Cdh3 in a mouse interspecific backcross. Cdh3 was found to be unlinked to the N-cadherin gene but linked to the E-cadherin (uvomorulin) locus on chromosome 8 in a region of conserved synteny with human chromosome 16q. The gene order cen-Junb-Um-Tat-(Cdh3/Aprt) was determined. The human homologue CDH3 was mapped to chromosome 16q24.1-qter by analyzing human/mouse somatic cell hybrids.
Kaupmann
K
K
Developmental Biology Unit, University of Bielefeld, Germany.
Becker-Follmann
J
J
Scherer
G
G
Jockusch
H
H
Starzinski-Powitz
A
A
D000818:Animals; D015139:Blotting, Southern; D015820:Cadherins / Q000235:genetics*; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D003433:Crosses, Genetic; D004247:DNA; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D008810:Mice, Inbred C57BL; D013045:Species Specificity
D015820:Cadherins; C070896:M-cadherin; D004247:DNA