Binary combination effects of some pharmacologically active chemicals as promoters of tumorigenesis.
Identification of potential interactions in exposures either to simultaneous or sequential combinations of carcinogenic chemicals and chemicals that modify carcinogenesis poses considerable difficulties in human health risk assessments. Studies of experimental carcinogenesis over the past four decades have revealed that many pharmacologically active agents possess tumorigenesis-promoting properties. The effort to identify the possible chemical structural basis of interactions of binary combinations of carcinogenic chemicals and chemical agents that modify carcinogenesis led to the identification of a class of structurally diverse and pharmacologically active tumorigenesis promoters that are known as pharmaceuticals. The chemical class-class interactions of carcinogens and pharmaceutical agents with reported tumorigenesis-promoting properties and the possible biochemical mechanism(s) that underlie such interactions are discussed.
Rao
V R
VR
Science Applications International Corporation, McLean, VA 22102.
D000818:Animals; D002273:Carcinogens / Q000494:pharmacology / Q000633:toxicity*; D016208:Databases, Factual; D004347:Drug Interactions; D009369:Neoplasms / Q000139:chemically induced; D013329:Structure-Activity Relationship
D002273:Carcinogens