title: Regional differences in gut blood flow and mucosal damage in response to ischemia and reperfusion.
abstract: Ischemia and reperfusion of the small intestine and colon in rats were produced by reversible occlusion (for 30 min and 1 or 3 h) of the superior mesenteric artery and the aorta above the inferior mesenteric artery. Despite a greater reduction of mucosal perfusion in the colon than in the small intestine with 30 min of ischemia, the depth of mucosal damage was significantly smaller in the former than in the latter. Thirty minutes of ischemia followed by 1 h of reperfusion induced an increase in polymorphonuclear leukocyte infiltration in both locations. Exacerbation of mucosal injury occurred only in the small intestine, suggesting that reperfusion injury is independent of polymorphonuclear leukocyte infiltration. Reperfusion after 1 or 3 h of ischemia did not exacerbate mucosal damage in either location. Allopurinol significantly diminished the exacerbation of injury after reperfusion in the small intestine. The protective effect of allopurinol, however, was neither associated with an improvement in perfusion nor a reduction in polymorphonuclear leukocyte infiltration. These data indicate that there is a window (30 min) of reperfusion injury in the small intestine, but there is no evidence of reperfusion injury in the colon.
authors.affiliation: Sepulveda Veterans Affairs Medical Center, California.
authors.forename: F W
authors.initials: FW
authors.lastname: Leung
authors.forename: K C
authors.initials: KC
authors.lastname: Su
authors.forename: E
authors.initials: E
authors.lastname: Passaro
authors.forename: P H
authors.initials: PH
authors.lastname: Guth
mesh_terms: D000493:Allopurinol / Q000494:pharmacology; D000818:Animals; D007413:Intestinal Mucosa / Q000473:pathology*; D007422:Intestines / Q000098:blood supply* / Q000187:drug effects; D007511:Ischemia / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow; D015424:Reperfusion; D015427:Reperfusion Injury / Q000473:pathology / Q000503:physiopathology*
chemical_list: D000493:Allopurinol