Pharmacokinetics of roxithromycin and influence of H2-blockers and antacids on gastrointestinal absorption.
The pharmacokinetics of roxithromycin (300 mg orally) and the influence of the antacid aluminum magnesium hydroxide and the H2-blocker ranitidine on bioavailability of roxithromycin in ten healthy volunteers were studied. Pharmacokinetics after a single dose of roxithromycin were characterized by high peak serum levels (9.1 +/- 2.1 mg/l) and a long elimination half-life (7.2 +/- 2.5 h), resulting in a large area under the curve (116.9 +/- 32.7 mg h/l). High inter- and intraindividual variations were found for both the absorption time and the elimination half-life. The bioavailability of roxithromycin was not affected by coadministration with antacids or ranitidine.
Boeckh
M
M
Medical Department, Universitätsklinikum Steglitz, Freie Universität Berlin, Germany.
Lode
H
H
Höffken
G
G
Daeschlein
S
S
Koeppe
P
P
D000328:Adult; D000536:Aluminum Hydroxide / Q000494:pharmacology*; D000863:Antacids / Q000494:pharmacology*; D001682:Biological Availability; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D008276:Magnesium Hydroxide / Q000494:pharmacology*; D008297:Male; D011899:Ranitidine / Q000494:pharmacology*; D015575:Roxithromycin / Q000493:pharmacokinetics*
D000863:Antacids; D004338:Drug Combinations; D015575:Roxithromycin; C013591:aluminum hydroxide, magnesium hydroxide, drug combination; D000536:Aluminum Hydroxide; D011899:Ranitidine; D008276:Magnesium Hydroxide