[The role of plasma fibronectin in the pathogenesis of post- aggressive conditions].
The interrelations of changes in plasma fibronectin (FN) level, hemostatic parameters and RES function were studied in the time course of traumatic or burn disease. A combination of interdependent disorders in the systems studied reflecting features of varying periods of extreme states was established in rat experiments. The analysis of the data obtained has suggested that FN is involved in the pathologic process and participates in the pathogenesis of shock and its complications by interacting with hemostasis and RES as a mediator thus playing an important role in maintaining the level of nonspecific body resistance.
Kharin
G M
GM
Zinkevich
O D
OD
Litvinov
R I
RI
D000276:Adjuvants, Immunologic; D000818:Animals; D001798:Blood Proteins / Q000032:analysis / Q000502:physiology; D002056:Burns / Q000097:blood / Q000150:complications / Q000276:immunology*; D004195:Disease Models, Animal; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis / Q000502:physiology; D005340:Fibrinogen / Q000032:analysis / Q000502:physiology; D005353:Fibronectins / Q000097:blood / Q000276:immunology*; D008297:Male; D012157:Mononuclear Phagocyte System / Q000276:immunology; D051381:Rats; D012774:Shock, Traumatic / Q000097:blood / Q000209:etiology / Q000276:immunology* / Q000517:prevention & control
D000276:Adjuvants, Immunologic; D001798:Blood Proteins; D005338:Fibrin Fibrinogen Degradation Products; D005353:Fibronectins; D005340:Fibrinogen
Uchastie plazmennogo fibronektina v patogeneze postagressivnykh sostoianiĭ.