Ventricular defibrillating properties of catecholamine uptake inhibitors.
Ventricular fibrillation (VF) is a fatal event in humans unless electrical defibrillation is applied within minutes. Recent publications describe spontaneous termination of VF in various animals and even in humans. Certain drugs can transfer a fatal, sustained VF (SVF) into a self-terminating, transient VF (TVF). Based on results obtained in animals of various species and ages, we have suggested that the occurrence of TVF requires a high cardiac catecholamine level at the time of VF. According to our hypothesis, drugs which decrease catecholamine reuptake by the sympathetic nerve terminals will increase the ability of the heart ventricles to defibrillate spontaneously. In the present study, we examined the effects of desipramine, maprotiline, mianserin, iprindole, cocaine and amphetamine on the type of VF in cats exhibiting SVF prior to the treatment. The results show that the ability of these compounds to transfer SVF to TVF is closely related to their potency to inhibit catecholamine reuptake. The establishment of the catecholamine related mechanisms of TVF may lead to the development of a new class of antiarrhythmic-defibrillatory drugs.
Manoach
M
M
Department of Physiology and Pharmacology, Sackler School of Medicine, Tel-Aviv University, Israel.
Erez
M
M
Wozner
D
D
Varon
D
D
D000661:Amphetamine / Q000627:therapeutic use*; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D002415:Cats; D003042:Cocaine / Q000627:therapeutic use*; D003891:Desipramine / Q000627:therapeutic use; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D007488:Iprindole / Q000627:therapeutic use; D008297:Male; D008376:Maprotiline / Q000627:therapeutic use; D008803:Mianserin / Q000627:therapeutic use; D014693:Ventricular Fibrillation / Q000188:drug therapy* / Q000503:physiopathology
D000929:Antidepressive Agents, Tricyclic; D008803:Mianserin; D008376:Maprotiline; D007488:Iprindole; D000661:Amphetamine; D003042:Cocaine; D003891:Desipramine