title: Portal vein thrombosis in a complicated case of Crohn's disease.
abstract: Portal vein thrombosis is a rare complication of ulcerative colitis and is invariably fatal. This report describes a patient with severe Crohn's disease who underwent elective surgery complicated by an anastomotic disruption with faecal peritonitis. Following emergency laparotomy he developed left hypochondrial pain which was a manifestation of splenomegaly consequent upon portal vein thrombosis. Anticoagulation was successful in preventing further spread of the thrombosis as monitored by colour Doppler ultrasound. Severe active disease, surgery and sepsis have been recognized as predisposing factors for thromboembolic complications in inflammatory bowel disease and this patient was exposed to all three. It is conceivable that portal vein thromboses occur more commonly than suspected and ultrasound scanning could ascertain the prevalence if performed prospectively.
authors.affiliation: Department of Gastrointestinal Surgery, St Thomas' Hospital, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Crowe
authors.forename: N
authors.initials: N
authors.lastname: Taffinder
authors.forename: G T
authors.initials: GT
authors.lastname: Layer
authors.forename: A
authors.initials: A
authors.lastname: Irvine
authors.forename: R J
authors.initials: RJ
authors.lastname: Nicholls
mesh_terms: D000328:Adult; D000792:Angiography; D003424:Crohn Disease / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D011169:Portal Vein / Q000000981:diagnostic imaging; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D014463:Ultrasonography
chemical_list: D006493:Heparin