Chlorpromazine induced aggregation of normal human hemoglobin. Electron microscopic evidence.
Normal human hemoglobin exceeding a certain minimum concentration (called critical aggregation concentration) undergoes aggregation in presence of the psychotherapeutic drug chlorpromazine (CPZ). The critical aggregation concentration decreases with the increase of CPZ concentration. Electron micrographs of CPZ-treated hemoglobin clearly indicate that the aggregates of hemoglobin are in filamentous form of average width 75 +/- 8 A. A possible mechanism for such aggregation has been discussed.
Bhattacharyya
M
M
Department of Biophysics, Molecular Biology and Genetics, University of Calcutta, India.
Ghosh
A N
AN
Chaudhuri
U
U
Poddar
R K
RK
D002746:Chlorpromazine / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects* / Q000648:ultrastructure; D006454:Hemoglobins / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D007700:Kinetics; D046911:Macromolecular Substances; D008854:Microscopy, Electron; D008961:Models, Structural
D006454:Hemoglobins; D046911:Macromolecular Substances; D002746:Chlorpromazine