[Changes in the vascular wall induced by surgical glues. Experimental study].
The effects on vascular tissues of two different types of surgical glue, gelatin-resorcinol-formaldehyde (GRF) and fibrin (Tissucol) were tested on the rat abdominal aorta. The GRF glue induced destruction of the vascular wall: multiple inclusions of the glue were noted in the media. Conversely, the fibrin glue preserved the normal architecture of the three arterial layers. The use of GRF glue therefore should be avoided on particularly fragile tissues (e.g. coronary arteries), and it seems preferable in such cases to use the fibrin glue.
Portoghese
M
M
Service de Chirurgie cardiovasculaire, Hôpital Broussais, Paris.
Acar
C
C
Jebara
V
V
Chachques
J C
JC
Fontaliran
F
F
Deloche
A
A
Carpentier
A
A
D000818:Animals; D001012:Aorta, Abdominal / Q000187:drug effects* / Q000473:pathology; D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive / Q000494:pharmacology* / Q000627:therapeutic use; D005557:Formaldehyde / Q000494:pharmacology* / Q000627:therapeutic use; D005780:Gelatin / Q000494:pharmacology* / Q000627:therapeutic use; D006488:Hemostasis, Surgical / Q000379:methods*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012118:Resorcinols / Q000494:pharmacology* / Q000627:therapeutic use
D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D012118:Resorcinols; C027813:gelatin-resorcinol-formaldehyde tissue adhesive; D005557:Formaldehyde; D005780:Gelatin
Altérations de la paroi vasculaire dues aux colles chirurgicales. Etude expérimentale.