title: [Radiochemotherapy concepts in advanced carcinomas of the mouth, oro- and hypopharynx].
abstract: Among combined radiochemotherapy regimens of advanced head and neck tumors four modalities can be discriminated: 1. Induction chemotherapy, 2. simultaneous radiochemotherapy, 3. adjuvant chemotherapy, 4. accelerated hyperfractionated radiotherapy and chemotherapy. The results of the presently available randomized trials are as follows: 1. Induction chemotherapy has no influence on long-term recurrence-free survival. 2. With respect to simultaneous radiochemotherapy, recurrence-free survival has been unproved with 5-FU and Mitomycin C. 3. There is evidence that adjuvant cisplatin therapy improves recurrence-free survival. 4. No results are available to date using hyperfractionated accelerated radiotherapy regimens in combination with chemotherapy.
authors.affiliation: Klinik für Strahlentherapie und Radiologische Onkologie, Universität Düsseldorf.
authors.forename: G
authors.initials: G
authors.lastname: Schmitt
authors.forename: T
authors.initials: T
authors.lastname: Schnabel
mesh_terms: D002277:Carcinoma / Q000188:drug therapy* / Q000532:radiotherapy*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D009959:Oropharyngeal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*
vernacular_title: Konzepte der Radio-Chemotherapie bei fortgeschrittenen Karzinomen der Mundhöhle, des Oro- und Hypopharynx.