[Delayed hypersensitivity to house dust-storage mites Thyrophagus putrescentiae in experimental allergic dermatoses].
House dust mites and storage mites proved to be one of the main allergens causing hypersensitivity in atopic dermatitis in allergic patients. The authors reproduced experimental allergic dermatosis on the model of delayed type hypersensitivity in guinea pigs, caused by sensitization to the allergen from the mite's bodies Tyrophagus putrescentiae--species having wide distribution in the country. The results characteristic for T-cell type hypersensitivity have been obtained: delayed positive skin tests after 24 hours, typical histomorphological picture (strong allergic alteration, epidermis desquamation, vasculitis, dermis T-cell infiltration and spongiosis--Waksman's syndrome). It is concluded that side by side with humoral IgE-mediated reaction there is strong delayed T-cell hypersensitivity to the storage mites Tyrophagus putrescentiae.
Ado
V A
VA
Mokronosova
M A
MA
Zheltikova
T M
TM
Iroshnikova
E S
ES
Alekseevskikh
Iu G
IuG
D000818:Animals; D001706:Biopsy; D003876:Dermatitis, Atopic / Q000276:immunology* / Q000473:pathology; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D008925:Mites / Q000276:immunology*; D012867:Skin / Q000473:pathology; D012882:Skin Tests; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors
D007073:Immunoglobulin E
Zamedlennyĭ tip povyshennoĭ chuvstvitel'nosti k kleshcham ambarno-zernovogo kompleksa Tyrophagus putrescentiae v éksperimental'nykh allergodermatozakh.