Lung adenoma development and NK activity in mice treated with multiple carcinogens.
A wide-spectrum initiation model was investigated in mice. Sequential treatments with diethylnitrosamine, urethane and N-methylnitrosourea, with or without a promoter, phenobarbital, resulted in tumor formation in the lungs in 85-90% of animals, but did not produce any tumorous lesions in other organs. The lung tumors were adenomas and the mean number of adenomas was 2.2-2.6 per mouse. Phenobarbital combination had no additive effect on lung tumor incidence and multiplicity. Splenic NK cell activity showed inconsistent increment in the carcinogen plus phenobarbital-treated group during the experiment (P less than 0.05).
Lee
Y S
YS
Laboratory of Cancer Pathology, Korea Cancer Center Hospital, Seoul.
Seo
J S
JS
Chung
H T
HT
Cho
K J
KJ
Jan
J J
JJ
D000236:Adenoma / Q000139:chemically induced / Q000276:immunology; D000818:Animals; D004052:Diethylnitrosamine / Q000494:pharmacology; D005260:Female; D007694:Killer Cells, Natural / Q000187:drug effects; D008175:Lung Neoplasms / Q000139:chemically induced / Q000276:immunology; D008770:Methylnitrosourea / Q000494:pharmacology; D051379:Mice; D010634:Phenobarbital / Q000494:pharmacology; D011897:Random Allocation; D014520:Urethane / Q000494:pharmacology
D014520:Urethane; D004052:Diethylnitrosamine; D008770:Methylnitrosourea; D010634:Phenobarbital