[Effects of peginol C-2000 on respiration and oxidative phosphorylation in liver mitochondria of rats poisoned with butylcaptax].
The data on the effect of synthetic antioxidant Paginol C-2000 on respiration and oxidative phosphorylation in liver mitochondria of rats primed with butylcaptax are given. It is shown that intoxication of organism with butylcaptax in the dose of 1/10 LD50 during 5 days resulted in suppression of respiration and oxidative phosphorylation in rat liver mitochondria. It is found, that administration of Raginol C-2000 into organisms of primed animals leads to the reduction of succinate pathway of oxidation, that, in its turn, results in the normalization of functioning level of ATP-synthesizing system of mitochondria.
Rustamov
R D
RD
Batirov
B M
BM
Tuĭchieva
D S
DS
Mirakhmedov
A K
AK
Khamidov
D Kh
DKh
D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D052160:Benzothiazoles; D003678:Defoliants, Chemical / Q000506:poisoning*; D007928:Lethal Dose 50; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D051381:Rats; D013844:Thiazoles / Q000506:poisoning*
D000975:Antioxidants; D052160:Benzothiazoles; D003678:Defoliants, Chemical; D013844:Thiazoles; C016283:butylcaptax; D000255:Adenosine Triphosphate
Vliianie peginola C-2000 na dykhanie i okislitel'noe fosforilirovanie mitokhondriĭ pecheni krys, otravlennykh butilkaptaksom.