title: Effect of cocaine, ethanol or nicotine on ornithine decarboxylase activity in early chick embryo brain.
abstract: Fetal drug exposure causes multiple deficits in the developing child. For both humans and animal models, the single most common drug-related problem is fetal growth suppression. This defect is associated with significant perinatal morbidity and mortality and may also be related to significant behavioral problems appearing later in life. Studies focussed on the molecular mechanism of fetal drug effects in placental models are complicated by multiple interactions of the drug with mother, placenta and fetus. Using early (76-168 h) chick embryos as a non-placental model, and three common drugs of abuse (nicotine, ethanol and cocaine) it was found that each drug suppressed the peak in fetal brain ornithine decarboxylase (ODC) activity that normally occurs at 120 h of development. For each drug, the decrease in ODC activity at 120 h was followed by a small but significant increase in ODC. Thus, although the drug-treated embryos were smaller in size, they appeared to be undergoing compensatory growth and, in fact, became equal in weight to the vehicle-treated animals, if allowed to hatch.
authors.affiliation: Department of Biochemistry, East Carolina University School of Medicine, Greenville, NC 27834.
authors.forename: K
authors.initials: K
authors.lastname: Beeker
authors.forename: C
authors.initials: C
authors.lastname: Smith
authors.forename: S
authors.initials: S
authors.lastname: Pennington
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000196:embryology / Q000201:enzymology*; D002642:Chick Embryo; D003042:Cocaine / Q000494:pharmacology*; D000518:Eflornithine / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology*; D009538:Nicotine / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D009955:Ornithine Decarboxylase / Q000378:metabolism*
chemical_list: D000431:Ethanol; D009538:Nicotine; D009955:Ornithine Decarboxylase; D003042:Cocaine; D000518:Eflornithine