[Comparative study of the action of Finoptin, Korinfar and Capoten in patients with stage II hypertensive disease].
The effects of Finoptin, Corinfar, and Capoten were examined in 154 patients with Stage II hypertensive disease. The calcium antagonists Finoptin and Corinfar, as well as Capoten were equal in lowering blood pressure and having a heterodirectional action on cardiodynamics: Finoptin exerted a positive inotropic effect in 46.3% and a negative one in 53.7%, corinfar in 66.7 and 33.3%, respectively, and Capoten in 37.5 and 62.5%. The baseline hemodynamic type fails to predict how the myocardium in a particular patient will respond to the antihypertensive drug. Nevertheless, Corinfar is more preferable in patients with hypertensive disease attended by hypokinetic circulation, Capoten is more preferable in those with its hyperkinetic variant. The baseline hemodynamic type makes an insignificant contribution to the activity of Finoptin.
Goloshchapov
O A
OA
Goldabin
V I
VI
Geller
A L
AL
Mashin
A A
AA
Rud'
S S
SS
D000328:Adult; D000368:Aged; D002216:Captopril / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects*; D009543:Nifedipine / Q000494:pharmacology* / Q000627:therapeutic use; D014700:Verapamil / Q000494:pharmacology* / Q000627:therapeutic use
D002216:Captopril; D014700:Verapamil; D009543:Nifedipine
Sravnitel'noe izuchenie aktivnosti finoptina, korinfara i kapotena u bol'nykh gipertonicheskoĭ bolezn'iu vtoroĭ stadii.