Evolution of sex determination and the Y chromosome: SRY-related sequences in marsupials.
In mammals, testis determination is under the control of the testis-determining factor borne by the Y chromosome. SRY, a gene cloned from the sex-determining region of the human Y chromosome, has been equated with the testis-determining factor in man and mouse. We have used a human SRY probe to identify and clone related genes from the Y chromosome of two marsupial species. Comparisons of eutherian and metatherian Y-located SRY sequences suggest rapid evolution of these genes, especially outside the region encoding the DNA-binding HMG box. The SRY homologues, together with the mouse Ube1y homologues, are the first genes to be identified on the marsupial Y chromosome.
Foster
J W
JW
Department of Genetics and Human Variation, La Trobe University, Bundoora, Victoria, Australia.
Brennan
F E
FE
Hampikian
G K
GK
Goodfellow
P N
PN
Sinclair
A H
AH
Lovell-Badge
R
R
Selwood
L
L
Renfree
M B
MB
Cooper
D W
DW
Graves
J A
JA
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D017124:Conserved Sequence; D004247:DNA / Q000737:chemistry; D015342:DNA Probes; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D006801:Humans; D051741:Kruppel-Like Transcription Factors; D008297:Male; D008394:Marsupialia / Q000235:genetics*; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid; D012732:Sex Determination Analysis; D014157:Transcription Factors; D014998:Y Chromosome
D015342:DNA Probes; D004268:DNA-Binding Proteins; D051741:Kruppel-Like Transcription Factors; D014157:Transcription Factors; C054430:ZFY protein, human; D004247:DNA