title: Organization of the human monoamine oxidase genes and long-range physical mapping around them.
abstract: A 265-kb yeast artificial chromosome containing sequences for human monoamine oxidase A and B (MAO-A and MAO-B) genes has been characterized. These two genes are localized within a region of about 240 kb and are arranged in a tail-to-tail configuration, with the 3' coding sequences separated by about 50 kb. A region about 2.5 Mb around the MAO loci was mapped by pulsed-field gel electrophoresis (PFGE). Comparisons between the restriction maps derived from the YAC and the long-range map derived from genomic digestions were in general agreement. The important features identified include a CpG island at the 5' end of the MAO-A and MAO-B genes, respectively. The combined information supports the order of markers within this region to be DXS77-DXS7-MAOA-MAOB.
authors.affiliation: Genetics Laboratory, Biochemistry Department, Oxford, United Kingdom.
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Chen
authors.forename: J F
authors.initials: JF
authors.lastname: Powell
authors.forename: Y P
authors.initials: YP
authors.lastname: Hsu
authors.forename: X O
authors.initials: XO
authors.lastname: Breakefield
authors.forename: I W
authors.initials: IW
authors.lastname: Craig
mesh_terms: D015342:DNA Probes; D016521:Electrophoresis, Gel, Pulsed-Field; D015723:Gene Library; D005800:Genes, Fungal; D015894:Genome, Human; D006801:Humans; D008995:Monoamine Oxidase / Q000235:genetics*; D015183:Restriction Mapping; D014960:X Chromosome
chemical_list: D015342:DNA Probes; D008995:Monoamine Oxidase