Transplantation of allogeneic fetal pancreases combined from MHC-different donor strains does not change rejection of the graft.
A number of 17.5- to 18.5-day-old fetal pancreases were grafted under the kidney capsule of streptozotocin-diabetic rats. Eight syngeneically grafted glands were sufficient to reverse the diabetes of the recipients within 4 weeks when the recipient rats were treated with insulin for 18 days after transplantation. Eight allogeneic fetal pancreases obtained from one donor strain were rejected after transplantation and the recipients relapsed into hyperglycemia immediately after insulin withdrawal. Eight allogeneic fetal pancreases obtained from eight MHC-different donor strains were also rejected and the recipients relapsed into hyperglycemia after insulin withdrawal. Using fetal pancreases as tissue sources, the combination of the allogeneic graft from different donor strains was not sufficient to prolong the survival time of the grafted tissue.
Kotzke
G
G
Institut für Diabetes Gerhardt Katsch, Karlsburg, Federal Republic of Germany.
Kauert
C
C
Lucke
S
S
Hahn
H J
HJ
D000818:Animals; D005260:Female; D016332:Fetal Tissue Transplantation; D006084:Graft Rejection; D007328:Insulin / Q000032:analysis; D008285:Major Histocompatibility Complex; D010179:Pancreas / Q000737:chemistry / Q000196:embryology; D016035:Pancreas Transplantation; D011247:Pregnancy; D051381:Rats; D011917:Rats, Inbred Lew
D007328:Insulin