Natriuretic hormones in young hypertensives and in young normotensives with or without a family history of hypertension.
The behavior of plasma atrial natriuretic factor (ANF) and digoxin-like substance (DLS), and the daily urinary excretion of kallikrein (uKK) were evaluated in young hypertensives and in young normotensives with or without a family history of essential hypertension. Each group was also evaluated, separating those with low plasma renin activity from the total sample. The sample group was made up of 75 young males; 31 hypertensives (mean age 22.7 +/- 2.5 years), 28 normotensives with hypertensive heredity (normotensives F+) (mean age 22.2 +/- 1.9 years) and 16 normotensives (mean age 22.0 +/- 2.1 years). An inverse correlation between ANF and PRA was shown in all groups. In hypertensives, ANF was inversely correlated with uKK (r = -0.664, P less than .0001). Plasma ANF (P less than .012) and DLS (P less than .0001) were higher in hypertensives than in normotensives, while uKK excretion was lower (P less than .0001). Plasma levels of DLS were higher in F+ normotensives than in normotensives (P less than .003). Low renin hypertensives showed the lowest uKK excretion (P less than .0001 v normal-high renin hypertensives). Furthermore, low renin hypertensives showed the highest plasma levels of ANF (P less than .0001 v normal high renin hypertensives) and DLS (P less than .012 v normal-high renin hypertensives). Plasma ANF (P less than .0001) was higher, while uKK was lower (P less than .045) in low renin F+ normotensives than in normal-high renin ones. In conclusion, our data indicate that plasma ANF and DLS are elevated since the early phase of hypertension.(ABSTRACT TRUNCATED AT 250 WORDS)
Musca
A
A
Institute of I Clinica Medica, Andrea Cesalpino Foundation, University of Rome La Sapienza, Italy.
Cammarella
I
I
Ferri
C
C
Bellini
C
C
Ruggeri
R
R
Santucci
A
A
Balsano
F
F
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood*; D004077:Digoxin / Q000097:blood*; D005192:Family Health; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000235:genetics / Q000652:urine*; D007610:Kallikreins / Q000652:urine*; D008297:Male; D012083:Renin / Q000097:blood
D004077:Digoxin; D009320:Atrial Natriuretic Factor; D007610:Kallikreins; D012083:Renin