Brominated polyacetylenic acids from the marine sponge Xestospongia muta: inhibitors of HIV protease.
The EtOAc extract of the sponge Xestospongia muta collected in Colombus Island, Bahamas, yielded eleven straight-chain unsaturated, polyacetylenic, brominated acids, seven of which were identified on the basis of spectral data, including the unknown acids 2-7. These acetylenic acids are the first known examples that have been shown to inhibit HIV protease, a critical enzyme in the replication of human immunodeficiency virus.
Patil
A D
AD
Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, Research and Development, King of Prussia, Pennsylvania 19406-09399.
Kokke
W C
WC
Cochran
S
S
Francis
T A
TA
Tomszek
T
T
Westley
J W
JW
D000818:Animals; D001896:Boron Compounds / Q000302:isolation & purification / Q000494:pharmacology*; D002478:Cells, Cultured; D005231:Fatty Acids, Unsaturated / Q000302:isolation & purification / Q000494:pharmacology*; D005612:Freeze Drying; D017320:HIV Protease Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D011161:Porifera / Q000737:chemistry*; D011817:Rabbits; D014020:Tissue Extracts / Q000494:pharmacology*
D001896:Boron Compounds; D005231:Fatty Acids, Unsaturated; D017320:HIV Protease Inhibitors; D014020:Tissue Extracts; D007770:L-Lactate Dehydrogenase