Insulin and growth factors adaptation to normal puberty.
Insulin and IGF-1 production were measured throughout childhood and puberty and into adult life. Basal insulin and IGF-1 secretion increased during puberty, falling back to prepubertal levels in adulthood. However, fasting glucose levels remained constant, implying an increase in tissue resistance to insulin coinciding with puberty.
Savage
M O
MO
Department of Endocrinology, St. Bartholomew's Hospital, London, UK.
Smith
C P
CP
Dunger
D B
DB
Gale
E A
EA
Holly
J M
JM
Preece
M A
MA
D000222:Adaptation, Physiological; D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood* / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology; D000078790:Insulin Secretion; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis* / Q000378:metabolism; D008297:Male; D011627:Puberty / Q000502:physiology*; D012016:Reference Values
D001786:Blood Glucose; D007328:Insulin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone