Effect of smoking on fibronectin production by human amnion and placenta.
Fibronectin production from amnion and placental tissues was evaluated in pregnant woman smokers and nonsmokers in order to examine if there were alterations of fibronectin metabolism in intrauterine tissues. In both amnion and placental tissues, cycloheximide inhibited the fibronectin output indicating that it was being synthesized. Mean fibronectin output by amnion in pregnant woman smokers was significantly lower than that in pregnant woman nonsmokers. In contrast, in the placenta from pregnant woman smokers, the output was significantly higher than that in pregnant woman nonsmokers. The present observations indicate that smoking alters an important biochemical constituent in amnion and placenta, possible leading to some complications.
Shimizu
T
T
Department of Obstetrics and Gynecology, Ottawa General Hospital, Ont., Canada.
Dudley
D K
DK
Borodchack
P
P
Belcher
J
J
Perkins
S L
SL
Gibb
W
W
D000650:Amnion / Q000378:metabolism*; D003513:Cycloheximide / Q000494:pharmacology; D005260:Female; D005353:Fibronectins / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D006801:Humans; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism*; D012907:Smoking / Q000009:adverse effects*; D013997:Time Factors
D005353:Fibronectins; D003513:Cycloheximide