[Effect of ethanol and ethylene glycol on the circadian rhythm of adenylic nucleotide levels in muscles].
The 24-hour's changes in ATP content in the gastrocnemiuses of intact rast are not significant. Both the ADP and AMP content is subjected to 24-hour's variations. It reaches its maximum within the time period from 12 to 15 o'clock p.m. for ADP and at 18 o'clock p.m. for AMP. Intragastric administration of ethanol and ethylene glycol to rats in a dose of 1/3 LD50 once per 24-hour period at 9 a. m. during a 7-days-long period dramatically changes the 24-hour's rhythm of adenylic nucleotide content in the rat gastrocnemius. It has been found that ethanol increases the average 24-hour's content of ATP, but decreases that of ADP. It increases the range of their 24-hour period variations and changes the acrophase. Ethylene glycol decreases the average 24-hour content of the both ATP and ADP, but it increases that of AMP. It changes their acrophases and increases the ranges of 24-hour-period variations of ATP.
Korkach
V I
VI
Spitkovskaia
L D
LD
D000227:Adenine Nucleotides / Q000378:metabolism*; D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D019855:Ethylene Glycol; D005026:Ethylene Glycols / Q000494:pharmacology*; D007441:Intubation, Gastrointestinal; D008297:Male; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism; D009539:Nicotinic Acids / Q000493:pharmacokinetics / Q000494:pharmacology*; D010119:Oxythiamine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D000227:Adenine Nucleotides; D005026:Ethylene Glycols; D009539:Nicotinic Acids; D010119:Oxythiamine; C077439:oxythiamine disulfide nicotinate; D000431:Ethanol; D019855:Ethylene Glycol
Vliianie étanola i etilenglikola na sutochnyĭ ritm soderzhaniia adenilovykh nukleotidov v myshtsakh.