The N-terminal region of n-Chimaerin allows lipid modulation of the C-terminal p21rac-GTPase activating domain.
Lee
J
J
Dept. of Neurochemistry, Institute of Neurology, London, U.K.
Ahmed
S
S
Kozma
R
R
Teo
M
M
Monfries
C
C
Lim
L
L
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D020848:Chimerin 1; D004075:Diglycerides / Q000378:metabolism*; D020690:GTPase-Activating Proteins; D006153:Guanosine Diphosphate / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010703:Phorbol Esters / Q000378:metabolism / Q000494:pharmacology; D010743:Phospholipids / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*
D020848:Chimerin 1; D004075:Diglycerides; D020690:GTPase-Activating Proteins; D009419:Nerve Tissue Proteins; D010703:Phorbol Esters; D010743:Phospholipids; D011506:Proteins; D006153:Guanosine Diphosphate; D006160:Guanosine Triphosphate; D011493:Protein Kinase C