Interleukin-10.
Despite the short history of interleukin-10, accumulated evidence indicates that this interleukin plays a major role in suppressing immune and inflammatory responses. Yet interleukin-10 also maintains cell viability and acts as a cofactor to promote the growth of lymphoid and myeloid cells in vitro. Here we review the present knowledge on the structure and function of interleukin-10.
de Waal Malefyt
R
R
Human Immunology Department, DNAX Research Institute, Palo Alto, California 94304-1104.
Yssel
H
H
Roncarolo
M G
MG
Spits
H
H
de Vries
J E
JE
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D016753:Interleukin-10 / Q000502:physiology*; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology; D008407:Mast Cells / Q000276:immunology; D009000:Monocytes / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D016753:Interleukin-10