Relationships among mammalian gonadotropin-releasing hormone, prostaglandins, and sex steroids in the brain of the crested newt, Triturus carnifex.
The present study was carried out to evaluate the in vitro brain release of prostaglandin F2 alpha (PGF2 alpha), prostaglandin E2 (PGE2), androgens, and 17 beta-estradiol in male and female crested newt, Triturus carnifex, during three different periods of the annual sexual cycle; in addition, the effects of mammalian gonadotropin-releasing hormone (mGnRH), PGF2 alpha, and PGE2 on prostaglandins and steroids release by the brain were evaluated during the same periods. In brain incubations of both sexes, PGF2 alpha and estradiol were higher during postreproduction, while PGE2 and androgens were higher during reproduction. In both sexes, mGnRH increased PGF2 alpha and estradiol during postreproduction, and PGE2 during reproduction; PGF2 alpha increased estradiol secretion during postreproduction. Only in the male, did both mGnRH and PGE2 increase androgens during reproduction. It could be suggested that in Triturus carnifex, the regulation of the reproductive activity in the central nervous system (CNS) depends on the relationships among mGnRH, prostaglandins and steroids. In particular, PGF2 alpha and PGE2 seem to play different roles in the CNS of the newt: PGF2 alpha is involved in the postreproductive processes, through estradiol secretion, while PGE2 in the reproductive ones (through androgens secretion?).
Gobbetti
A
A
Department of Molecular, Cellular and Animal Biology, University of Camerino, Italy.
Zerani
M
M
Cardellini
L B
LB
D000728:Androgens / Q000032:analysis; D000818:Animals; D001921:Brain / Q000378:metabolism*; D015237:Dinoprost / Q000032:analysis; D015232:Dinoprostone / Q000032:analysis; D004958:Estradiol / Q000032:analysis; D005260:Female; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D008297:Male; D008322:Mammals / Q000502:physiology; D011453:Prostaglandins / Q000378:metabolism*; D011863:Radioimmunoassay; D012098:Reproduction / Q000502:physiology; D013256:Steroids / Q000378:metabolism*; D014319:Triturus / Q000378:metabolism*
D000728:Androgens; D012739:Gonadal Steroid Hormones; D011453:Prostaglandins; D013256:Steroids; D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D015237:Dinoprost; D015232:Dinoprostone