Stability of long-term renal function in heart transplant patients treated with induction therapy and low-dose cyclosporine.
Long-term renal function was evaluated in heart transplant recipients who were treated with antilymphocyte globulin induction therapy and low-dose cyclosporine therapy. Although an initial 16% drop in the glomerular filtration rate occurred, long-term follow-up revealed stability of renal function. Four-year patient survival was 77.6%. Use of induction therapy with low-dose cyclosporine may preserve renal function without compromising long-term patient survival.
Gonwa
T A
TA
Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas.
Mai
M L
ML
Pilcher
J
J
Johnson
C
C
Pierson
S
S
Capehart
J E
JE
Alivizatos
P A
PA
D000961:Antilymphocyte Serum / Q000627:therapeutic use*; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects*; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000187:drug effects; D016027:Heart Transplantation; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000502:physiology
D000961:Antilymphocyte Serum; D016572:Cyclosporine; D003404:Creatinine