Stress fractures in young athletic women: case reports of unsuspected cortisol-induced osteoporosis.
Stress fractures in the female athlete are common events, usually occurring in the lower limb and less often in the pelvic girdle. Two cases are presented of young women athletes who presented with initial lower limb stress fractures, but subsequently fractures of the pelvis and hip thought to be associated with their athletic activity. After careful medical evaluation, they were diagnosed with Cushing's syndrome. One patient had a microadenoma of the pituitary gland secreting excessive amounts of ACTH, and the other had a benign adenoma of the left adrenal gland. Both women had significant decreases in their spinal mineral density. After treatment, partial reversal of these spinal losses occurred. Although stress fractures in the female athlete might be common and thought to be associated with problems of amenorrhea, presentation of unusual anatomical sites for these fractures necessitates a more thorough evaluation for correctable secondary causes.
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Department of Endocrinology, Cleveland Clinic Foundation, OH 44195.
D000236:Adenoma / Q000150:complications; D000310:Adrenal Gland Neoplasms / Q000150:complications; D000308:Adrenocortical Hyperfunction / Q000150:complications; D000328:Adult; D001265:Athletic Injuries / Q000209:etiology*; D015519:Bone Density; D003480:Cushing Syndrome / Q000150:complications; D005260:Female; D015775:Fractures, Stress / Q000209:etiology*; D006801:Humans; D006854:Hydrocortisone / Q000502:physiology*; D010024:Osteoporosis / Q000209:etiology*; D010911:Pituitary Neoplasms / Q000150:complications
D006854:Hydrocortisone