title: Folding kinetics of designer proteins. Application of the diffusion-collision model to a de novo designed four-helix bundle.
abstract: A folding algorithm is described, based on the diffusion-collision model, combining static and dynamic calculational methods. The algorithm is applied to predict the basic structure and schematic folding pathways of an artificial four-helix bundle.
authors.affiliation: Department of Physics, Tufts University, Medford, Massachusetts 02155.
authors.forename: K K
authors.initials: KK
authors.lastname: Yapa
authors.forename: D L
authors.initials: DL
authors.lastname: Weaver
mesh_terms: D000595:Amino Acid Sequence; D055592:Biophysical Phenomena; D001703:Biophysics; D004058:Diffusion; D015195:Drug Design; D007700:Kinetics; D008956:Models, Chemical; D008969:Molecular Sequence Data; D011487:Protein Conformation; D015202:Protein Engineering; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins