CDw 60 antibodies bind to acetylated forms of ganglioside GD3.
Four monoclonal antibodies, M-T21, M-T32, M-T41 and UM4D4, which belong to the new CDw 60 cluster of antibodies specific for a subpopulation of human T-lymphocytes, were found to bind mainly to acetylated forms of ganglioside GD3. After O-deacetylation of the antigen, binding was reduced ("M-T"-antibodies) or abolished (UM4D4).
Kniep
B
B
GBF-Gesellschaft für Biotechnologische Forschung mbH, Braunschweig, FRG.
Peter-Katalinić
J
J
Flegel
W
W
Northoff
H
H
Rieber
E P
EP
D000107:Acetylation; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000918:Antibody Specificity; D015703:Antigens, CD / Q000276:immunology*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D002240:Carbohydrate Sequence; D002851:Chromatography, High Pressure Liquid; D005732:Gangliosides / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; C064741:CDw60 antigen; D005732:Gangliosides; C026226:ganglioside, GD3