title: Lipid solubility of sedative-hypnotic drugs influences hypothermic and hypnotic responses of long-sleep and short-sleep mice.
abstract: The anesthetic potency of many agents, including alcohols, barbiturates and other sedative-hypnotic drugs, is influenced by lipid solubility. Previous studies from our laboratory, however, have demonstrated that genetic factors influence this relationship. We have reported that mouse lines selectively bred for differences in duration of ethanol-induced anesthesia, the long-sleep (LS) and short-sleep (SS) mice, differ in sleep-time response to water-soluble, but not lipid-soluble, sedative-hypnotic drugs. The studies described here sought to determine whether this same relationship exists for the hypothermic response produced by 17 sedative-hypnotic drugs in the LS and SS mice. Dose-response and time course relationships for hypothermic actions were determined and were compared with the dose-related anesthetic effects of the drugs. Hypothermic potencies increased along with lipid solubility for both the LS and SS mouse lines, but the rate of change differed for the two mouse lines. LS mice were more responsive to ethanol and other water-soluble drugs whereas the SS were more responsive to lipid-soluble drugs; significant correlations were obtained between lipid solubility (log P-octanol-water partition coefficient) and relative LS-SS responsiveness to both the hypothermic and hypnotic actions of the 17 test drugs. Thus, both hypnotic and hypothermic actions of sedative-hypnotic drugs are correlated with lipid solubility. Possible explanation for these correlations include greater LS central nervous system sensitivity to water-soluble drugs and LS-SS differences in distribution of lipid-soluble drugs.
authors.affiliation: Institute for Behavioral Genetics, School of Pharmacy, University of Colorado, Boulder.
authors.forename: N C
authors.initials: NC
authors.lastname: De Fiebre
authors.forename: R J
authors.initials: RJ
authors.lastname: Marley
authors.forename: J M
authors.initials: JM
authors.lastname: Wehner
authors.forename: A C
authors.initials: AC
authors.lastname: Collins
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D007035:Hypothermia / Q000139:chemically induced*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D012890:Sleep / Q000187:drug effects*; D012995:Solubility
chemical_list: D006993:Hypnotics and Sedatives