Lack of association of nonsteroidal anti-inflammatory drug use and cognitive decline in the elderly.
Folstein Mini-Mental State Examination (MMSE) scores obtained in an ambulatory elderly population were used to examine the effect of nonsteroidal anti-inflammatory drug (NSAID) use on cognitive performance. There were 1,310 participants who met the inclusion criteria for the study, of whom 873 (66.6%) were women and 437 (33.3%) were men. There were no differences in mean MMSE scores or in the five dimensions of cognitive function measured by the MMSE for subjects reporting NSAIDs or aspirin use.
May
F E
FE
Department of Pharmacy Practice, College of Pharmacy, University of Florida, Gainesville.
Moore
M T
MT
Stewart
R B
RB
Hale
W E
WE
D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects; D003072:Cognition Disorders / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008297:Male; D011581:Psychological Tests
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin