title: Effect of moderate exercise on rat T-cells.
abstract: The aim of this study was a detailed examination of the effects of moderate exercise on T-cells in adult male Wistar rats. The T-cell populations were compared in sedentary rats (C, n = 5) and in rats trained for 4 weeks on a treadmill (30-60 min.day-1, 6 days.week-1, 20-30 m.min-1) and sacrificed at rest (T-rest, n = 5). In the T-rest rats, there were higher percentages of CD4+CD8-, CD4-CD8+ and CD4-CD8- thymocytes (P < 0.05, P < 0.05 and P < 0.01 respectively) and of CD4-CD8+ splenocytes (P < 0.01), and a lower percentage of CD4-CD8+ cells in the lymph nodes (P < 0.01). Compared with T-rest or C rats, trained rats (n = 5) or untrained rats (n = 5) sacrificed immediately after a running session (60 min, 30 m.min-1) had a higher percentage of mononucleated cells CD4+CD8- in the blood (P < 0.05 and P < 0.01). Lastly, compared with C rats, rats (n = 5) sacrificed immediately after their 5th day of training (30-60 min.day-1) presented a higher total splenocyte population (P < 0.05) and greater in vitro production of T-cell growth factor (interleukin 2 + Interleukin 4) by splenocytes in response to a mitogen (P < 0.01). These results would indicate that moderate endurance training modifies the cellular composition of lymphoid organs, without impairing the in vitro functions of T-cells.
authors.affiliation: Laboratoire de Physiologie des Adaptations, U.F.R. Cochin Port-Royal, Université Paris V, France.
authors.forename: A
authors.initials: A
authors.lastname: Ferry
authors.forename: P
authors.initials: P
authors.lastname: Rieu
authors.forename: F
authors.initials: F
authors.lastname: Laziri
authors.forename: A
authors.initials: A
authors.lastname: el Habazi
authors.forename: C
authors.initials: C
authors.lastname: Le Page
authors.forename: M
authors.initials: M
authors.lastname: Rieu
mesh_terms: D000818:Animals; D016516:CD4-CD8 Ratio; D007376:Interleukin-2 / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D007958:Leukocyte Count; D008198:Lymph Nodes / Q000166:cytology; D008297:Male; D010805:Physical Conditioning, Animal; D005082:Physical Exertion / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000166:cytology; D016176:T-Lymphocyte Subsets / Q000166:cytology*; D013601:T-Lymphocytes / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology
chemical_list: D007376:Interleukin-2; D015847:Interleukin-4