Inhibitory effects of AcSDKP on the mixed lymphocyte reaction (MLR). Part I. MLR with mouse spleen cells.
AcSDKP (inhibitor of entry into cycle of pluripotent hemopoietic stem cells) is able to decrease mixed lymphocyte reaction intensity when H-2 incompatible allogeneic spleen cells are used as stimulators. This is a first approach to determining whether AcSDKP has potential therapeutic value for clinical bone marrow transplantation.
Frindel
E
E
Faculté de Médecine de Limoges, Laboratoire de Biochimie Médicale, Limoges, France.
Massé
A
A
Volkov
L
L
Lavignac
C
C
Rigaud
M
M
D000595:Amino Acid Sequence; D000818:Animals; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects*; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology
D009842:Oligopeptides; C058504:goralatide