title: Murine survival of lethal irradiation with the use of human umbilical cord blood.
abstract: We have found that human umbilical cord blood (HUCB) will routinely protect mice exposed to lethal levels of irradiation. At the end of 50 days, over seventy percent (70%) of mice injected with HUCB survived 900 cGy or irradiation, which produced 100% deaths in the uninjected control animals. Moreover, there was some evidence that human colony stimulating factors further improved survival. Anti-Natural Killer cell (NK) antibody was utilized along with HUCB in these studies, however, Anti-NK cell serum alone had no radioprotective effect in mice. The studies reported here suggest the possibility of utilizing HUCB for immediate protection of humans from lethal irradiation.
authors.affiliation: UMDNJ, New Jersey Medical School, Newark 07103-2714.
authors.forename: N
authors.initials: N
authors.lastname: Ende
authors.forename: N M
authors.initials: NM
authors.lastname: Ponzio
authors.forename: R S
authors.initials: RS
authors.lastname: Athwal
authors.forename: M
authors.initials: M
authors.lastname: Ende
authors.forename: D C
authors.initials: DC
authors.lastname: Giuliani
mesh_terms: D000818:Animals; D003115:Colony-Stimulating Factors / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003524:Cyclosporins / Q000627:therapeutic use*; D005312:Fetal Blood; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains; D011833:Radiation Injuries, Experimental / Q000628:therapy*; D016019:Survival Analysis
chemical_list: D003115:Colony-Stimulating Factors; D003524:Cyclosporins