Vitamin B-6 depletion followed by repletion with animal- or plant-source diets and calcium and magnesium metabolism in young women.
An 84-98-d study was conducted in young women to determine the effect of vitamin B-6-deficient diets on calcium and magnesium metabolism. A vitamin B-6-deficient formula diet fed initially was followed by either animal- or plant-source protein food diets containing four increasing amounts of vitamin B-6. Calcium balance was negative during vitamin B-6 depletion. Serum calcium was higher and calcium balance negative with the plant protein diets. Magnesium balance was negative during vitamin B-6 depletion due to increased urinary magnesium excretion. Urinary calcium decreased during vitamin B-6 depletion and increased as dietary vitamin B-6 increased. Urinary oxalate was significantly higher at the end than at the beginning of vitamin B-6 depletion and was higher with plant than animal protein diets. The results suggest that vitamin B-6 depletion may alter calcium and magnesium metabolism and that dietary components associated with the protein source may influence calcium retention.
Turnlund
J R
JR
Western Human Nutrition Research Center, USDA/ARS, Presidio of San Francisco, CA 94129.
Betschart
A A
AA
Liebman
M
M
Kretsch
M J
MJ
Sauberlich
H E
HE
D000328:Adult; D000818:Animals; D002118:Calcium / Q000097:blood / Q000378:metabolism* / Q000652:urine; D004044:Dietary Proteins / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008274:Magnesium / Q000097:blood / Q000378:metabolism* / Q000652:urine; D010070:Oxalates / Q000652:urine; D019815:Oxalic Acid; D010945:Plants, Edible; D011736:Pyridoxine / Q000008:administration & dosage*; D026681:Vitamin B 6 Deficiency / Q000188:drug therapy / Q000378:metabolism*
D004044:Dietary Proteins; D010070:Oxalates; D019815:Oxalic Acid; D008274:Magnesium; D011736:Pyridoxine; D002118:Calcium