title: Endoscopic creation and repair of fetal cleft lip.
abstract: In utero repair of several life-threatening malformations in the human fetus is now a clinical reality, yet fetal surgery still poses significant risks to both the mother and the unborn child. Preterm labor is a major problem and is directly related to the large hysterotomy required for fetal exposure. Endoscopic surgical manipulation of the fetus, through small uterine "ports," solves this problem and may eventually permit fetal intervention for non-life-threatening malformations. In this pilot study we demonstrated the feasibility of performing endoscopic surgery on the fetus in situ. A lip incision was created and repaired using endoscopic microsurgical techniques in midgestation fetal lambs. This represents the first application of this technique for in utero fetal intervention.
authors.affiliation: Fetal Treatment Program, University of California, San Francisco.
authors.forename: J M
authors.initials: JM
authors.lastname: Estes
authors.forename: D J
authors.initials: DJ
authors.lastname: Whitby
authors.forename: H P
authors.initials: HP
authors.lastname: Lorenz
authors.forename: M T
authors.initials: MT
authors.lastname: Longaker
authors.forename: Z
authors.initials: Z
authors.lastname: Szabo
authors.forename: N S
authors.initials: NS
authors.lastname: Adzick
authors.forename: M R
authors.initials: MR
authors.lastname: Harrison
mesh_terms: D000818:Animals; D002971:Cleft Lip / Q000209:etiology / Q000601:surgery*; D005260:Female; D005332:Fetoscopy; D005333:Fetus / Q000601:surgery*; D007327:Insufflation; D008866:Microsurgery / Q000379:methods; D010865:Pilot Projects; D011247:Pregnancy; D012756:Sheep; D013518:Surgery, Plastic / Q000379:methods*; D013536:Suture Techniques; D014945:Wound Healing / Q000502:physiology*