[The interaction of moradol (butorphanol tartrate) and flormidal (midazolam) in the patient's body].
Twenty five female patients (3 groups) operated on for cholelithiasis without premedication have been examined. In patients of group F an effective flormidal dose (EFD) causing an unconscious state upon intravenous injection by a measuring device has been determined. Due to an insufficient sedative effect of moradol it was impossible to determine an effective moradol dose (EMD). In group M+F right after intravenous administration of a standard moradol dose (SMD) flormidal infusion was begun, as in patients of group F. EFD after moradol injection (EFMD) was determined. Making proportions with known EFD, EFMD and SMD values, EMD was calculated. Upon intravenous administration of the calculated EMD by a measuring device the sedative effect was superficial in all the patients of group M and it was impossible to achieve an unconscious state. The interaction of moradol (butorphanol tartrate) and flormidal (midazolam) in the patients' body is of synergic nature.
Byshovets
S N
SN
Treshchinskiĭ
A I
AI
D002077:Butorphanol / Q000008:administration & dosage*; D002769:Cholelithiasis / Q000601:surgery*; D004357:Drug Synergism; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008874:Midazolam / Q000008:administration & dosage*
D002077:Butorphanol; D008874:Midazolam
Vzaimodeĭstvie moradola (butorfanola tartrata) i flormidala (midazolama) v organizme bol'nykh.