Studies on thermophile products. IV. Structural elucidation of cytotoxic substance, BS-1, derived from Bacillus stearothermophilus.
A new cytotoxic substance designated as BS-1 was isolated from the autolysate and culture filtrate of Bacillus stearothermophilus UK563. On the basis of spectral data, the structure of BS-1 was determined as bis(2-hydroxyethyl) trisulfide and confirmed by direct comparison with the synthetic compound. BS-1 exhibited potent cytotoxicity against leukemia P388-D1, leukemia P388, mastocytoma P815, lymphoma EL4 and lymphoma MOLT4.
Kohama
Y
Y
Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Iida
K
K
Semba
T
T
Mimura
T
T
Inada
A
A
Tanaka
K
K
Nakanishi
T
T
D000970:Antineoplastic Agents / Q000032:analysis* / Q000494:pharmacology; D000431:Ethanol / Q000031:analogs & derivatives* / Q000032:analysis / Q000494:pharmacology; D001411:Geobacillus stearothermophilus / Q000737:chemistry*; D013440:Sulfides / Q000032:analysis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D013440:Sulfides; D000431:Ethanol; C077818:bis(2-hydroxyethyl)trisulfide