[The effect of ionizing radiation at superhigh doses on the processes of dopamine release and reuptake by nerve endings in different sections of the brain].
Rats exposed to fast 24 MeV electrons (100 Gy) at the state of early transient incapacity (ETI) exhibited active release and reuptake of dopamine in nerve terminals of the striatum. No changes in the indices under study were found in rats exposed to 25 Gy radiation that did not cause the ETI development. The in vitro irradiation of the isolated synaptosomes (100 Gy) inhibited dopamine reuptake and increased the number of sites of 3H-spiperone binding to D2-receptors in a membrane fraction isolated from the striatum.
Mikhaĭlov
V F
VF
Vodolazskaia
N A
NA
Prianishnikova
E N
EN
Solov'eva
S V
SV
Mazurik
V K
VK
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism* / Q000528:radiation effects*; D003342:Corpus Striatum / Q000378:metabolism* / Q000528:radiation effects*; D004298:Dopamine / Q000378:metabolism* / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D004583:Electrons; D008297:Male; D009411:Nerve Endings / Q000378:metabolism* / Q000528:radiation effects*; D010315:Particle Accelerators; D051381:Rats; D017448:Receptors, Dopamine D2 / Q000378:metabolism / Q000528:radiation effects; D013134:Spiperone / Q000378:metabolism / Q000528:radiation effects; D013574:Synaptosomes / Q000378:metabolism / Q000528:radiation effects; D014316:Tritium
D017448:Receptors, Dopamine D2; D014316:Tritium; D013134:Spiperone; D004298:Dopamine
Vliianie ioniziruiushchego izlucheniia v sverkhvysokikh dozakh na protsessy vysvobozhdeniia i obratnogo zakhvata dofamina nervnymi terminaliami razlichnykh otdelov golovnogo mozga.