Biogenesis of storage granules and vesicles.
The production of storage granules and vesicles that undergo regulated exocytosis occurs via biosynthetic and endocytotic pathways, respectively. Prominent in the formation of secretory granules in the Golgi apparatus is selective protein aggregation, which may account for the biogenesis of multiple granules in a single cell. New cDNA transfection and immunolocalization studies have helped to further refine our understanding of the relationship between the formation of regulated secretory vesicles and the early stages of the endocytotic pathway. Recent insights into the targeting of membrane proteins to these organelles have implicated both specific sorting signals and protein-protein aggregation.
Rindler
M J
MJ
New York University Medical Center, New York.
D000818:Animals; D003594:Cytoplasmic Granules / Q000378:metabolism*; D004705:Endocytosis / Q000502:physiology*; D008081:Liposomes / Q000378:metabolism*; D008565:Membrane Proteins / Q000096:biosynthesis* / Q000378:metabolism
D008081:Liposomes; D008565:Membrane Proteins