Discriminant validity of a reduced set of Mini-Mental State Examination items for dementia and Alzheimer's disease.
Linear discriminant analysis was used to construct a series of discriminant functions including subsets of demographic variables and Mini-Mental State Examination item responses for a case series and a population sample. A 9-item discriminant function including the variables for time orientation, recall, calculation, copying a figure, age, writing, 3-step command, naming, and race distinguished demented subjects from community controls with 91% sensitivity and 88% specificity. The same discriminant function classified Alzheimer's disease patients and controls with 96% sensitivity and 98% specificity. This discriminant function has been cross-validated as a potential screening instrument for Alzheimer's disease in a community-based sample.
Wells
J C
JC
Department of Mental Hygiene, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland.
Keyl
P M
PM
Chase
G A
GA
Aboraya
A
A
Folstein
M F
MF
Anthony
J C
JC
D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000209:etiology / Q000523:psychology; D003072:Cognition Disorders / Q000150:complications / Q000523:psychology; D003704:Dementia / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011379:Prognosis