title: [Antipyrine metabolism and rat liver ultrastructure in single and combined action of trichlorodiphenyl and dioctyl phthalate].
abstract: As shown by animal experiments, low-dose trichlorodophenyl and dioctyl phthalate induce microsomal cytochrome P-450-dependent enzymes and ultrastructural changes in hepatocytes. This evidences hepatotoxicity of the compounds.
authors.forename: R V
authors.initials: RV
authors.lastname: Gorenkov
authors.forename: P N
authors.initials: PN
authors.lastname: Liubchenko
authors.forename: E A
authors.initials: EA
authors.lastname: Bendikov
authors.forename: V B
authors.initials: VB
authors.lastname: Potapova
authors.forename: A V
authors.initials: AV
authors.lastname: Petrakov
authors.forename: V V
authors.initials: VV
authors.lastname: Ul'ianova
mesh_terms: D000818:Animals; D000983:Antipyrine / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004051:Diethylhexyl Phthalate / Q000008:administration & dosage / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D008930:Mitochondria, Liver / Q000187:drug effects / Q000648:ultrastructure; D011078:Polychlorinated Biphenyls / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats
chemical_list: D003577:Cytochrome P-450 Enzyme System; D004051:Diethylhexyl Phthalate; D011078:Polychlorinated Biphenyls; D000983:Antipyrine
vernacular_title: Metabolizm antipirina i ul'trastruktura pecheni krys pri izolirovannom i sochetannom deĭstvii trikhlordifenila i dioktilftalata.