title: [Cyclosporine in the treatment of psoriasis].
abstract: Psoriasis is a chronic inflammatory skin disease of unknown etiology. An immune-reaction mediated by T lymphocytes is important in the pathogenesis. Cyclosporin is a selective immuno-suppressant that inhibits helper T lymphocytes. Several controlled clinical studies have shown that cyclosporin is highly effective in controlling severe psoriasis. The main side effects are hypertension, nephrotoxicity and increased risk of developing malignancies, particularly after long-term treatment. Side effects during short-term therapy appear to be reversible. Some questions connected to the long-term use and safety of cyclosporin are still unsolved.
authors.affiliation: Hudavdelingen, Medisinsk klinikk, Ullevål sykehus, Oslo.
authors.forename: J R
authors.initials: JR
authors.lastname: Bjerke
mesh_terms: D016572:Cyclosporine / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D011565:Psoriasis / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology
chemical_list: D016572:Cyclosporine
vernacular_title: Cyklosporin i behandlingen av psoriasis.