Mapping around the Xq13.1 breakpoints of two X/A translocations in hypohidrotic ectodermal dysplasia (EDA) female patients.
Cellular hybrids were obtained from a t(X;12) identified in a female patient with hypohidrotic ectodermal dysplasia (EDA). This rearrangement had the same Xq13.1 cytogenetic breakpoint as a t(X;9) found in a previously observed EDA patient. A comparative analysis of these two rearrangements with nine probes was performed at the molecular level. These probes could define three subregions: three are proximal, two are distal, and four are between the two breakpoints. These last probes should prove useful for cloning the gene.
Plougastel
B
B
U173 INSERM, Hôpital Necker Enfants Malades, Paris, France.
Couillin
P
P
Blanquet
V
V
Le Guern
E
E
Bakker
E
E
Turleau
C
C
De Grouchy
J
J
Créau-Goldberg
N
N
D015139:Blotting, Southern; D002873:Chromosome Fragility; D002881:Chromosomes, Human, Pair 12; D002899:Chromosomes, Human, Pair 9; D004476:Ectodermal Dysplasia / Q000235:genetics*; D005260:Female; D006801:Humans; D014178:Translocation, Genetic; D014960:X Chromosome