title: Evolution of sex determination and the Y chromosome: SRY-related sequences in marsupials.
abstract: In mammals, testis determination is under the control of the testis-determining factor borne by the Y chromosome. SRY, a gene cloned from the sex-determining region of the human Y chromosome, has been equated with the testis-determining factor in man and mouse. We have used a human SRY probe to identify and clone related genes from the Y chromosome of two marsupial species. Comparisons of eutherian and metatherian Y-located SRY sequences suggest rapid evolution of these genes, especially outside the region encoding the DNA-binding HMG box. The SRY homologues, together with the mouse Ube1y homologues, are the first genes to be identified on the marsupial Y chromosome.
authors.affiliation: Department of Genetics and Human Variation, La Trobe University, Bundoora, Victoria, Australia.
authors.forename: J W
authors.initials: JW
authors.lastname: Foster
authors.forename: F E
authors.initials: FE
authors.lastname: Brennan
authors.forename: G K
authors.initials: GK
authors.lastname: Hampikian
authors.forename: P N
authors.initials: PN
authors.lastname: Goodfellow
authors.forename: A H
authors.initials: AH
authors.lastname: Sinclair
authors.forename: R
authors.initials: R
authors.lastname: Lovell-Badge
authors.forename: L
authors.initials: L
authors.lastname: Selwood
authors.forename: M B
authors.initials: MB
authors.lastname: Renfree
authors.forename: D W
authors.initials: DW
authors.lastname: Cooper
authors.forename: J A
authors.initials: JA
authors.lastname: Graves
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D017124:Conserved Sequence; D004247:DNA / Q000737:chemistry; D015342:DNA Probes; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D006801:Humans; D051741:Kruppel-Like Transcription Factors; D008297:Male; D008394:Marsupialia / Q000235:genetics*; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid; D012732:Sex Determination Analysis; D014157:Transcription Factors; D014998:Y Chromosome
chemical_list: D015342:DNA Probes; D004268:DNA-Binding Proteins; D051741:Kruppel-Like Transcription Factors; D014157:Transcription Factors; C054430:ZFY protein, human; D004247:DNA