[Study of thyroid function in the organ donor during brain death].
OBJECTIVE
To determine the thyroid function in organ donors undergoing cerebral death and evaluate the effects that these possible alterations may exert on the early function of renal graft.


METHODS
Prospective study. Hormonal analysis when: 1) the diagnosis of cerebral death was made and 2) before organ extraction.


METHODS
Fifteen organ donors with cerebral death. Twenty-nine patients who received the kidneys of these donors.


METHODS
Neurotraumatologic Unit at the University Hospital Marques de Valdecilla. Referring center.


RESULTS
All donors showed low T3 and T4 values. Values of T4 and IT4L were significantly lower during the second determination (p < 0.05). Eighty percent of donors showed increased T3r values. TSH was low in 73% of cases. Dopamine requirements in donors or the incidence of acute tubular necrosis in recipients were not significantly higher in donors with lowest T3 values.


CONCLUSIONS
The hormonal picture observed in the donors of this study is more characteristic of a "ill euthyroid syndrome" than a real hypothyroidism. The low values of T3 in donors is not associated with higher requirements of inotropic agents, nor with a higher incidence of acute tubular necrosis in renal grafts.
Rabanal
J M
JM
Departamento de Anestesiología-Reanimación, Hospital Universitario Marqués de Valdecilla, Santander.
Amado
J A
JA
Quesada
A
A
Solares
G
G
Díaz
J
J
Vázquez
A
A
D000293:Adolescent; D000328:Adult; D001926:Brain Death / Q000503:physiopathology*; D002648:Child; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013961:Thyroid Gland / Q000502:physiology*; D013963:Thyroid Hormones / Q000378:metabolism; D014019:Tissue Donors
D013963:Thyroid Hormones
Estudio de la función tiroidea en el donante de órganos en muerte cerebral.