Effect of torasemide on intracranial pressure, mean systemic arterial pressure and cerebral perfusion pressure in experimental brain edema of the rat.
The study was performed to establish whether a lipophilic loop diuretic, torasemide could modify intracranial pressure and cytotoxic brain edema. Brain edema was induced by water intoxication in nephrectomized rats. Following intravenous injection of 100 mg torasemide/kg body weight at 50, 60, 70, 90 and 120 min, a significant decrease of intracranial pressure was observed.
Plangger
C
C
Department of Neurosurgery, University Hospital, Innsbruck, Austria.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000098:blood supply*; D001929:Brain Edema / Q000503:physiopathology*; D004232:Diuretics / Q000494:pharmacology*; D007427:Intracranial Pressure / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D013449:Sulfonamides / Q000494:pharmacology*; D000077786:Torsemide
D004232:Diuretics; D013449:Sulfonamides; D000077786:Torsemide