title: [Disorders of bone marrow hematopoiesis long time after the action of cytostatic preparations].
abstract: We studied the condition of CBA mice bone marrow hemopoiesis and functional activity of adherent cells 6 months after a single treatment with vinblastine (VB), doxorubicin (DR) and cyclophosphamide (CP) in LD10 dose (6, 22 and 250 mg/kg, respectively). There was a long-term disorganization of bone marrow cell composition. The damage may be attributed to exhaustion of the pools of stem cells and changes in function of the cells formed by hemopoiesis induction microenvironment.
authors.forename: I V
authors.initials: IV
authors.lastname: Bogdashin
authors.forename: E V
authors.initials: EV
authors.lastname: Sycheva
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: O N
authors.initials: ON
authors.lastname: Afanas'eva
authors.forename: O P
authors.initials: OP
authors.lastname: Zapuskalova
authors.forename: V V
authors.initials: VV
authors.lastname: Novitskiĭ
authors.forename: E D
authors.initials: ED
authors.lastname: Gol'dberg
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001853:Bone Marrow / Q000187:drug effects*; D003520:Cyclophosphamide / Q000009:adverse effects; D004317:Doxorubicin / Q000009:adverse effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013997:Time Factors; D014747:Vinblastine / Q000009:adverse effects
chemical_list: D000970:Antineoplastic Agents; D014747:Vinblastine; D004317:Doxorubicin; D003520:Cyclophosphamide
vernacular_title: Narushenie kostnomozgovogo krovetvoreniia v otdalennye sroki posle deĭstviia tsitostaticheskikh preparatov.