title: Effect of insulin therapy on blood pressure in NIDDM patients with secondary failure.
abstract: OBJECTIVE
  To assess the effect of insulin therapy on blood pressure in NIDDM patients with secondary failure.
  
  
  METHODS
  The influence of insulin treatment on blood pressure was assessed retrospectively in a group of 80 NIDDM patients with secondary failure to diet and maximum doses of oral hypoglycemic agents. Weight, blood glucose, and blood pressure were recorded over a 3-mo period before and after the initiation of insulin therapy.
  
  
  RESULTS
  There was a significant rise in systolic (131.8 +/- 1.7 to 148 +/- 1.9 mmHg, P less than 0.05) and diastolic (80.9 +/- 0.9 to 89.2 +/- 1.0 mmHg, P less than 0.02) blood pressures with insulin treatment. Insulin treatment was associated with a significant decrease in blood glucose (18.36 +/- 0.28 to 10.4 +/- 0.34 mM, P less than 0.01) and an increase in weight (72.1 +/- 1.6 to 78 +/- 1.7 kg, P = 0.01). A control group of 80 NIDDM patients matched for age, weight, BMI, and duration of diabetes demonstrated no significant change in blood pressure over a matched period of follow-up.
  
  
  CONCLUSIONS
  This study has shown that insulin therapy is associated with significant elevation of both systolic and diastolic blood pressures.
authors.affiliation: Department of Medicine, University of Natal, Durban, South Africa.
authors.forename: H A
authors.initials: HA
authors.lastname: Randeree
authors.forename: M A
authors.initials: MA
authors.lastname: Omar
authors.forename: A A
authors.initials: AA
authors.lastname: Motala
authors.forename: M A
authors.initials: MA
authors.lastname: Seedat
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects*; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000503:physiopathology*; D003971:Diastole / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D007328:Insulin / Q000627:therapeutic use*; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013599:Systole / Q000187:drug effects; D015430:Weight Gain / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D007328:Insulin