[Turner's syndrome and pregnancy in donor oocytes and in vitro fertilization. Three case reports].
It is extremely rare for pregnancy to occur spontaneously in a woman with a mosaic or non-mosaic karyotype 45 x 0. (Till now only 13 patients with a homogeneous x 0 karyotype have been reported out of 62 patients who between them have had 138 pregnancies). Furthermore these pregnancies have been plagued by a number of important complications or fetal malformations (21% have had chromosome anomalies). It is therefore clear that in vitro fertilization with donor oocytes is a tempting solution for these women. The authors having three personal cases try and point out the conditions under which this technique can be used. It is important to realise that from the age of 10 or 12 years these patients have to have hormone treatment in order to avoid hypoplasia and hypovascularization of the uterus. Those conditions explain why so many these women had premature labours and also suffer from pre-eclampsia. Caesarean section was often found to be necessary because of feto-pelvic disproportion.
Leclercq
G
G
Service de Gynécologie-Obstétrique, Lille.
Buvat-Herbaut
M
M
Monnier
J C
JC
Vinatier
D
D
Dufour
P
P
D000328:Adult; D002985:Clinical Protocols / Q000592:standards; D004958:Estradiol / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D007621:Karyotyping; D009865:Oocytes; D011247:Pregnancy; D011256:Pregnancy Outcome; D011374:Progesterone / Q000008:administration & dosage / Q000627:therapeutic use; D011379:Prognosis; D014019:Tissue Donors; D014424:Turner Syndrome / Q000150:complications* / Q000235:genetics
D011374:Progesterone; D004958:Estradiol
Syndrome de Turner et grossesse par dons d'ovocytes et fécondation in vitro. A propos de trois cas.