title: Efficacy of Cydectin moxidectin 1% injectable against experimental infections of Dictyocaulus viviparus and Bunostomum phlebotomum superimposed on natural gastrointestinal infections in calves.
abstract: Twenty male Holstein calves averaging 105 kg in weight and naturally infected with gastrointestinal nematodes and small numbers of lungworm and hookworm, were given experimental infections with the two latter species to provide adult and larval stages for anthelmintic evaluation. Following random allotment, one group of 10 calves was injected subcutaneously with moxidectin at a dosage of 0.2 mg kg-1 of body weight. A second group of 10 was injected subcutaneously with unmedicated blank vehicle at a dosage of 1 ml per 50 kg of body weight. Fecal samples were examined before treatment and at 7 and 13 days after treatment. The 20 calves were necropsied for worm recovery at 13 and 14 days after treatment. All calves were positive for lungworm and hookworm on the treatment date. Treatment was 100% effective in elimination of hookworm eggs and lungworm larvae and 99.9% in reducing total egg counts at both 7 and 13 days after treatment. Moxidectin was 100% effective (P less than 0.01) in eliminating the following 11 species of nematodes. Dictyocaulus viviparus mature and immature adults (E5), Bunostomum phlebotomum adults and L4, Ostertagia ostertagi adults and early L4, Ostertagia lyrata adult males, Haemonchus placei adults. Trichostrongylus axei adults, Cooperia spp., including Cooperia punctata, Cooperia spatulata, and Cooperia pectinata adults, Oesophagostomum radiatum adults and Trichuris discolor adults. No adverse reactions to moxidectin treatment were observed.
authors.affiliation: Department of Veterinary Science, Louisiana Agricultural Experiment Station, Baton Rouge 70803.
authors.forename: J C
authors.initials: JC
authors.lastname: Williams
authors.forename: C
authors.initials: C
authors.lastname: Nault
authors.forename: R T
authors.initials: RT
authors.lastname: Ramsey
authors.forename: G T
authors.initials: GT
authors.lastname: Wang
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D004022:Dictyocaulus Infections / Q000150:complications / Q000188:drug therapy*; D005243:Feces / Q000469:parasitology; D006725:Hookworm Infections / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D007279:Injections, Subcutaneous / Q000662:veterinary; D007411:Intestinal Diseases, Parasitic / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D018942:Macrolides; D008297:Male; D009349:Nematode Infections / Q000150:complications / Q000188:drug therapy / Q000662:veterinary; D010270:Parasite Egg Count / Q000662:veterinary; D011897:Random Allocation
chemical_list: D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D018942:Macrolides; C027837:moxidectin