title: Spectrometric investigations in ocular hypertension and early stages of primary open angle glaucoma and of low tension glaucoma--multisubstance analysis.
abstract: The approximation of logarithmic difference spectra between the reflectance of the normal fundus and the fundus reflectance in different stages of glaucoma is demonstrated by a model. The influences of fundus pigments like oxihemoglobin, melanin, xanthophyll and rhodopsin as well as the intensity and the exponent of the scattered light are optimized. Glaucomatous alterations in the extinction of these pigments and of the scattering parameters are different in the macula, in the papillo-macular bundle and in the parapapillary region temporal to the optic disc. A lack of oxihemoglobin only in the papillo-macular bundle in first relative losses in the visual field function points to a damaged microcirculation in early POAG. In progressive glaucoma the extinction spectrum of xanthophyll is detectable in the papillo-macular bundle. A decreased intensity of the scattered light and an altered scattering exponent are suggestive of a damage in the nerve fiber layer at early stages of glaucoma.
authors.affiliation: Department of Ophthalmology, University of Jena, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Schweitzer
authors.forename: S
authors.initials: S
authors.lastname: Guenther
authors.forename: M
authors.initials: M
authors.lastname: Scibor
authors.forename: M
authors.initials: M
authors.lastname: Hammer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005654:Fundus Oculi; D005902:Glaucoma, Open-Angle / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007429:Intraocular Pressure; D008027:Light; D014975:Lutein / Q000378:metabolism; D008833:Microcirculation; D008875:Middle Aged; D009798:Ocular Hypertension / Q000378:metabolism* / Q000473:pathology; D015814:Ocular Hypotension / Q000378:metabolism* / Q000473:pathology; D011897:Random Allocation; D012168:Retinal Pigments / Q000378:metabolism*; D012171:Retinal Vessels / Q000378:metabolism; D012542:Scattering, Radiation; D013053:Spectrophotometry
chemical_list: D012168:Retinal Pigments; D014975:Lutein