Mechanisms of soluble mediators.
A two chain model, composed of ligand-binding and signal transducing subunits, first identified in the interleukin-6 receptor system, has been revealed in several other cytokine systems. Common signal transducers shared by several receptor systems may explain a functional redundancy characteristic of cytokines. The signaling pathway from the receptor to gene activation is now becoming clearer due to the successful molecular cloning of several transcription factors.
Akira
S
S
Osaka University, Japan.
Kishimoto
T
T
D000818:Animals; D016207:Cytokines / Q000502:physiology*; D006410:Hematopoiesis / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D015398:Signal Transduction / Q000276:immunology; D014157:Transcription Factors / Q000502:physiology
D016207:Cytokines; D014157:Transcription Factors