Genetic analysis of ras homologs in yeasts.
Ras proteins with extensive structural homology to mammalian p21ras have been studied in the two yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe. Comparative analysis of these two yeasts has revealed significant differences in the biochemical and physiological functions that are controlled by this subgroup of eukaryotic GTP-binding regulatory proteins. Despite such divergence of cellular functions, proteins and mechanisms involved in the regulation and modification of Ras proteins are highly conserved in yeasts and other eukaryotes. Genetic analysis of the function of yeast proteins that regulate or modify Ras proteins has provided important information about Ras proteins in general.
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Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway 08854.
D000262:Adenylyl Cyclases / Q000378:metabolism; D020690:GTPase-Activating Proteins; D005786:Gene Expression Regulation; D011905:Genes, ras / Q000502:physiology*; D011499:Protein Processing, Post-Translational / Q000502:physiology; D011506:Proteins / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D012568:Schizosaccharomyces / Q000235:genetics*; D020703:ras GTPase-Activating Proteins
D020690:GTPase-Activating Proteins; D011506:Proteins; D020703:ras GTPase-Activating Proteins; D000262:Adenylyl Cyclases