title: Miliary tuberculosis with acute respiratory failure and histiocytic hemophagocytosis. Successful treatment with extracorporeal lung support and epipodophyllotoxin VP 16-213.
abstract: A 14-year-old girl with high fever, dyspnea and bilateral miliary nodules on chest X-ray, developed a rapidly progressive respiratory failure associated with histiocytic hemophagocytosis. Histologic examination of bone marrow biopsy revealed tuberculous granulomas with caseating necrosis. We report a pediatric case in which treatment with extracorporeal lung support and epipodophyllotoxin VP 16-213 was successful.
authors.affiliation: Intensive Care Department, Trousseau Hospital, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Monier
authors.forename: B
authors.initials: B
authors.lastname: Fauroux
authors.forename: J Y
authors.initials: JY
authors.lastname: Chevalier
authors.forename: G
authors.initials: G
authors.lastname: Leverger
authors.forename: M
authors.initials: M
authors.lastname: Nathanson
authors.forename: J
authors.initials: J
authors.lastname: Costil
authors.forename: G
authors.initials: G
authors.lastname: Tournier
mesh_terms: D000293:Adolescent; D005047:Etoposide / Q000627:therapeutic use*; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D015616:Histiocytosis, Non-Langerhans-Cell / Q000150:complications / Q000628:therapy*; D006801:Humans; D011859:Radiography; D012131:Respiratory Insufficiency / Q000150:complications / Q000628:therapy*; D013577:Syndrome; D014391:Tuberculosis, Miliary / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*
chemical_list: D005047:Etoposide