title: Comparison of acute and steady-state conditions of gallopamil therapy in stable angina pectoris.
abstract: We studied 12 patients with stable effort angina in a randomized, double-blind, cross-over and placebo-controlled trial to compare the different antianginal efficacy of "acute" and "chronic" (after reaching a steady-state level) gallopamil therapy. Efficacy was assessed using treadmill exercise testing (Bruce protocol) after a 50 mg single-dose and at the end of a nine-dose course of 50 mg of gallopamil (given three times a day). Three daily exercise tests were performed the first, second, fifth and eighth day of the study protocol at 8, 12 and 16 h. Four hours after a single-dose of gallopamil 50 mg both angina-free exercise time and time to 1 mm ST segment depression increased by a mean value of 78 s (p < 0.003) and 53 s (p < 0.03), respectively, with respect to placebo values. Under steady-state conditions exercise time and time to 1 mm ST segment depression increased by a mean value of 59 s (p < 0.009) and 46 s (p < 0.015), respectively, 4 h after the last dose. The duration of the anti-ischemic effects was no longer present after 8 h for both treatment schedules. Furthermore no significant differences were observed on parameters of ischemia after a single dose as compared to "chronic" therapy. The results of this study reveal that, in accordance with the pharmacodynamic properties of the drug, the anti-ischemic efficacy of 50 mg of gallopamil remains for approximately 4 h. Reaching a steady-state condition does not imply a prolongation of the anti-ischemic effect.
authors.affiliation: Servicio de Cardiología, Hospital Valdecilla, Santander, Spain.
authors.forename: F G
authors.initials: FG
authors.lastname: Vilchez
authors.forename: T
authors.initials: T
authors.lastname: Villarroel
authors.forename: J
authors.initials: J
authors.lastname: Ruano Calvo
authors.forename: J A
authors.initials: JA
authors.lastname: Vazquez de Prada
authors.forename: R
authors.initials: R
authors.lastname: Martin-Duran
authors.forename: J M
authors.initials: JM
authors.lastname: San Jose
authors.forename: A
authors.initials: A
authors.lastname: Pajaron
mesh_terms: D000787:Angina Pectoris / Q000097:blood / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004562:Electrocardiography / Q000187:drug effects; D005080:Exercise Test / Q000187:drug effects; D005260:Female; D005711:Gallopamil / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D005711:Gallopamil