Accuracy of the results measured by in vivo 1H-MRS using model solutions.
In in vivo 1H-MRS of human brain, main three metabolites such as N-acetyl-L-aspartate (NAA), creatine/phosphocreatine (PCr/Cr), and choline (Cho) have been observed. In this paper an accuracy of the results measured by in vivo 1H-MRS using above model solutions was discussed. 1.0 mmol/l choline and 1.5 mmol/l creatine/phosphocreatine saline solutions were measured with STEAM method (echo time 270 msec). The peak area of Cho was larger than that of PCr/Cr against their concentrations and was linearly increased with its concentration in the range of 5.8 and 29 mumol/27 cm3. Although both peak areas of Cho and Cr/PCr were varied with Volume-of-interest (VOI) coordinates, the ratio of Cho to PCr/Cr was approximately 1.6.
Miyoshi
H
H
Department of Radiological Technology, School of Medical Sciences, University of Tokushima, Japan.
Harada
M
M
Moribe
T
T
Nishitani
H
H
D001921:Brain / Q000378:metabolism*; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D004734:Energy Metabolism; D006801:Humans; D006859:Hydrogen; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008959:Models, Neurological; D010725:Phosphocreatine / Q000378:metabolism; D012996:Solutions
D012996:Solutions; D010725:Phosphocreatine; D006859:Hydrogen; D003401:Creatine; D002794:Choline