[New 5'-phosphonates, modified through the nucleoside sugar residue, as inhibitors of HIV replication].
A number of nucleoside 5'-phosphonates and nucleoside 5'-methylphosphonates were synthesised, to study their ability to inhibit reproduction of HIV-1. Three compounds, 5'-hydrogen phosphonates of 3'-azido-2',3'-dideoxythymidine (AZT-HP, IVc), 3'-fluoro-2',3'-dideoxythymidine (FLT-HP, IVa) and 2',3'-dideoxyadenosine (ddA-HP, I), exhibit potent anti-HIV-1 activity with selectivity indices similar to or better of those of their parent nucleosides.
Kraevskiĭ
A
A
Tarusova
N
N
Zhu
K Iu
KIu
Vidal
P
P
Chu
T Ch
TCh
Pol'ski
B
B
Iang
K Iu
KIu
Matulich-Adamich
Ia
Ia
Rozenberg
I
I
Vatanabe
K A
KA
D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002241:Carbohydrates / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D015497:HIV-1 / Q000502:physiology*; D009682:Magnetic Resonance Spectroscopy; D009705:Nucleosides / Q000737:chemistry / Q000494:pharmacology*; D009943:Organophosphorus Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D002241:Carbohydrates; D009705:Nucleosides; D009943:Organophosphorus Compounds
Novye 5'-fosfonaty modifitsirovannykh po sakharnomu ostatku nukleozidovkak ingibitory produktsii VICh.