[Is A29, B12 vasculitis caused by the Q fever agent? (Coxiella burnetii)].
The authors describe the first two cases, to their knowledge, of retinal vasculitis, associated with Q fever. The first case was a chronic infection induced by Coxiella burnetii associated with HLA group A29 and B12; in the second case, the phenotype was B12. The authors tried to determine whether this agent could be the "Birdshot chorioretinopathy" promoting factor. Several epidemiologic findings tend to prove that Q fever is not the only cause. On the other hand, its similarity with rickettsia, the fact that it is found in patients with vasculitis, suggest that it could be one of the initial causal factors.
Kuhne
F
F
Service d'Ophtalmologie, Hôpital Pellegrin, Bordeaux.
Morlat
P
P
Riss
I
I
Dominguez
M
M
Hostyn
P
P
Carniel
N
N
Paix
M A
MA
Aubertin
J
J
Raoult
D
D
Le Rebeller
M J
MJ
D000328:Adult; D000368:Aged; D005260:Female; D015234:HLA-A Antigens / Q000032:analysis; D015235:HLA-B Antigens / Q000032:analysis; D006801:Humans; D008297:Male; D011778:Q Fever / Q000150:complications*; D012171:Retinal Vessels; D012173:Retinitis / Q000276:immunology / Q000382:microbiology*; D012189:Retrospective Studies
D015234:HLA-A Antigens; C035524:HLA-A29 antigen; D015235:HLA-B Antigens; C035015:HLA-B12 antigen
La vascularite A29, B12, est-elle déclenchée par l'agent de la fièvre Q? (Coxiella burnetii).