title: Spleen: dynamic enhancement patterns on gradient-echo MR images enhanced with gadopentetate dimeglumine.
abstract: To examine the pattern of immediate enhancement with gadopentetate dimeglumine on dynamic magnetic resonance (MR) images of the spleen, this study was divided into two parts: In the first part, the authors retrospectively reviewed the dynamic MR images obtained with a fast low-angle shot (FLASH) sequence in the abdomen immediately after injection of gadopentetate dimeglumine in 137 patients. In the second part, dynamic gadolinium-enhanced FLASH images were prospectively compared with contrast material-enhanced computed tomographic (CT) scans in 17 patients with focal splenic lesions discovered on CT scans. In the first part, 108 patients (79%) had an arciform pattern of contrast enhancement; 22 patients (16%), a uniform pattern of high signal intensity; and seven patients (5%), a uniform pattern of low signal intensity. Most patients had arciform enhancement of the spleen; uniform enhancement occurred in some patients with underlying malignant or inflammatory disease. In the second part, all focal lesions seen on CT scans were seen on dynamic MR images (75 lesions), significantly more than were seen on FLASH images (15 lesions) (P < .001).
authors.affiliation: MRI Facility, St Boniface General Hospital, University of Manitoba, Winnipeg, Canada.
authors.forename: R C
authors.initials: RC
authors.lastname: Semelka
authors.forename: J P
authors.initials: JP
authors.lastname: Shoenut
authors.forename: P H
authors.initials: PH
authors.lastname: Lawrence
authors.forename: H M
authors.initials: HM
authors.lastname: Greenberg
authors.forename: T P
authors.initials: TP
authors.lastname: Madden
authors.forename: M A
authors.initials: MA
authors.lastname: Kroeker
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D004338:Drug Combinations; D005260:Female; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008536:Meglumine; D008875:Middle Aged; D009942:Organometallic Compounds; D004369:Pentetic Acid; D011446:Prospective Studies; D012189:Retrospective Studies; D016037:Single-Blind Method; D013154:Spleen / Q000000981:diagnostic imaging / Q000473:pathology*; D013158:Splenic Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D004338:Drug Combinations; D009942:Organometallic Compounds; D008536:Meglumine; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA