General pharmacology of pergolide in animals. 2nd communication: gastrointestinal, renal and miscellaneous studies.
Pergolide mesylate ((8 beta)-8-[(methylthio)methyl]-6-propylergoline monomethanesulfonate, LY 127809, CAS 66104-23-2) is a novel and potent dopamine agonist marketed for treating the symptoms of Parkinson's disease. The potential secondary pharmacological effects of this agent on the gastrointestinal and renal systems, as well as effects on local anesthesia, hemolysis, platelet aggregation, circulating blood glucose, primary antibody production, and the acute inflammatory response were examined. Pergolide exhibited significant pharmacological effects in gastrointestinal, renal and anti-inflammatory tests at high oral doses. Pergolide was essentially inactive in blood hemolysis, platelet aggregation, primary antibody production and local anesthesia testing. In summary, these studies confirm the pharmacological selectivity of pergolide, and indicate a low potential for secondary pharmacological side effects upon the functions tested at clinically relevant doses.
Williams
P D
PD
Lilly Research Laboratories, Eli Lilly and Company, Greenfield, Indiana.
Bendele
A
A
Deldar
A
A
McGrath
J
J
Shetler
T
T
Owen
N
N
D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism; D003404:Creatinine / Q000097:blood; D004064:Digestive System / Q000187:drug effects*; D004573:Electrolytes / Q000097:blood; D005260:Female; D006168:Guinea Pigs; D006461:Hemolysis / Q000187:drug effects; D007249:Inflammation / Q000139:chemically induced / Q000473:pathology; D007668:Kidney / Q000187:drug effects*; D008297:Male; D051379:Mice; D010479:Pergolide / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D011916:Rats, Inbred F344; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D012018:Reflex / Q000187:drug effects
D000779:Anesthetics, Local; D001786:Blood Glucose; D004573:Electrolytes; D010479:Pergolide; D003404:Creatinine