[Imbalance of amino acid metabolism in fulminant hepatitis and its management].
Fulminant hepatitis shows characteristic imbalance of amino acid levels; increased aromatic amino acid (AAA) and methionine. Elevated plasma AAA may cause hepatic encephalopathy and BCAA-enriched amino acids solution (BCAAs). Glucagon-Insulin (G-I) therapy and artificial liver support system have been proposed to correct the imbalance of amino acids. BCAAs and G-I therapy correct the aberrant amino acid patterns and artificial liver support system, including plasma pheresis, and charcoal haemoperfusion has also been used to reduce plasma amino acids levels. While imbalance of amino acids level in fulminant hepatitis is a result of acute necrosis of a large proportion of hepatocytes, careful and sufficient management of the disease is essential to normalize amino acid profiles.
Kato
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A
First Department of Internal Medicine, School of Medicine, Iwate Medical University.
Suzuki
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K
Sato
S
S
D000597:Amino Acids, Branched-Chain / Q000627:therapeutic use; D005934:Glucagon / Q000627:therapeutic use; D006501:Hepatic Encephalopathy / Q000188:drug therapy / Q000378:metabolism*; D006505:Hepatitis / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D008715:Methionine / Q000378:metabolism*; D010649:Phenylalanine / Q000378:metabolism*; D014443:Tyrosine / Q000378:metabolism*
D000597:Amino Acids, Branched-Chain; D007328:Insulin; D014443:Tyrosine; D010649:Phenylalanine; D005934:Glucagon; D008715:Methionine