title: Acromegaly and its treatment in the McCune-Albright syndrome.
abstract: The McCune-Albright syndrome, comprising polyostotic fibrous dysplasia, cutaneous pigmentation and endocrine hyperfunction, is occasionally complicated by acromegaly due to a pituitary adenoma. We report a patient with the McCune-Albright syndrome and acromegaly, who developed secondary hypothyroidism and hypoadrenalism, in whom surgical removal of the pituitary tumour was technically difficult. A combination of a long-acting somatostatin analogue ('Sandostatin') and external irradiation were therefore used as treatment.
authors.affiliation: Department of Medicine, University of Wales College of Medicine, Cardiff, UK.
authors.forename: L D
authors.initials: LD
authors.lastname: Premawardhana
authors.forename: J P
authors.initials: JP
authors.lastname: Vora
authors.forename: R
authors.initials: R
authors.lastname: Mills
authors.forename: M F
authors.initials: MF
authors.lastname: Scanlon
mesh_terms: D000172:Acromegaly / Q000209:etiology / Q000628:therapy*; D000236:Adenoma / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D005357:Fibrous Dysplasia of Bone / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D015282:Octreotide / Q000627:therapeutic use; D010911:Pituitary Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy
chemical_list: D015282:Octreotide