title: Pteroylpolyglutamate pool modifications in rat liver after chronic administration of phenobarbitone and valproate.
abstract: Chronic intraperitoneal administration of low doses of phenobarbitone and valproate caused different alterations in hepatic percentage distribution of pteroylpolyglutamate derivatives without modification of total folate content. Phenobarbitone treatment caused a significant decrease of the percentage content of reduced unsubstituted and methylene-substituted derivatives, while valproate produced an increase of the percentage content of methenyl-, formyl- and formimino-substituted derivatives and a concomitant percent increase of hexaglutamates. The modified ratios of various pteroylpolyglutamates, both in phenobarbitone- and in valproate-treated animals, probably contribute to influencing the partitioning of the one-carbon pool through the various areas of one-carbon metabolism.
authors.affiliation: Department of Biochemistry, University of Bologna, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Bovina
authors.forename: G
authors.initials: G
authors.lastname: Formiggini
authors.forename: S
authors.initials: S
authors.lastname: Sassi
authors.forename: M
authors.initials: M
authors.lastname: Battino
authors.forename: M
authors.initials: M
authors.lastname: Marchetti
mesh_terms: D000818:Animals; D005492:Folic Acid / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology*; D011624:Pteroylpolyglutamic Acids / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014635:Valproic Acid / Q000494:pharmacology*
chemical_list: D011624:Pteroylpolyglutamic Acids; D014635:Valproic Acid; D005492:Folic Acid; D010634:Phenobarbital