title: Loxoscelism.
abstract: Loxoscelism, or envenomation by the brown recluse spider, may result in necrotic lesions and systemic reactions, including hemolytic anemia. Histologically, it resembles a cutaneous Arthus reaction. The reaction mechanism involves interactions between complement, neutrophils, and the clotting system. It is best treated with analgesics, avoidance of early surgical debridement, and oral dapsone.
authors.affiliation: Tulane University Medical School, Department of Dermatology, New Orleans, Louisiana 70112.
authors.forename: J M
authors.initials: JM
authors.lastname: Futrell
mesh_terms: D000818:Animals; D006801:Humans; D001098:Spider Bites / Q000503:physiopathology* / Q000517:prevention & control / Q000628:therapy; D013112:Spiders