Neurotoxic effect of prenatal exposure to MPTP on the dopaminergic systems of the marmoset brain.
MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) was incidentally administered to pregnant marmosets during the whole gestational period, except for the last 15 days before term. The infant monkeys were killed 5 months after birth, and dopamine and its metabolites were measured in the striatum and the nucleus accumbens. Prenatal exposure to MPTP produced a marked dopamine depletion in these brain regions of the offspring, showing that MPTP is able to cross the placental barrier in primates.
Pérez-Otaño
I
I
Department of Pharmacology, University of Navarra Medical School, Pamplona, Spain.
Oset
C
C
Trinidad Herrero
M
M
Luquin
M R
MR
Kupsch
A
A
Oertel
W
W
Obeso
J A
JA
Del Río
J
J
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000008:administration & dosage / Q000494:pharmacology*; D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000293:Adolescent; D000818:Animals; D002144:Callithrix; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D006719:Homovanillic Acid / Q000378:metabolism; D006801:Humans; D009714:Nucleus Accumbens / Q000378:metabolism*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
D015102:3,4-Dihydroxyphenylacetic Acid; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D004298:Dopamine; D006719:Homovanillic Acid