Electrolytes, protein, and lactate dehydrogenase isozymes of parotid saliva in mineralocorticoid-treated rats.
Small quantities of parotid saliva were obtained from 7 of 11 rats in which hypokalemia was induced by treatment with deoxycorticosterone acetate (DOCA). Thirst in the treated rats was indicated by an increase in water consumption. A decrease of 28% in plasma potassium levels indicated that the DOCA-treated rats had become hypokalemic; chloride decreased 6-7% while sodium was unchanged. Saliva showed significant increases in potassium and protein and a decrease in sodium; lactate dehydrogenase-2 and -4 bands appeared darker on the electrophoretic profile. These changes are relevant to the clinical manifestations and diagnosis of hypokalemia.
Yu
Z H
ZH
Shanghai Institute of Physiology, Academia Sinica, China.
D000818:Animals; D003900:Desoxycorticosterone / Q000494:pharmacology*; D004326:Drinking; D004573:Electrolytes / Q000378:metabolism*; D006996:Hypocalcemia / Q000097:blood / Q000139:chemically induced / Q000378:metabolism; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000378:metabolism*; D008297:Male; D010306:Parotid Gland / Q000378:metabolism*; D011188:Potassium / Q000097:blood; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D012463:Saliva / Q000378:metabolism*
D004573:Electrolytes; D007527:Isoenzymes; D011506:Proteins; D003900:Desoxycorticosterone; D007770:L-Lactate Dehydrogenase; D011188:Potassium