[Severely burned patients and atracurium: the train-of-four response].
Severely burned patients show a relative hyposensitivity to atracurium. The neuromuscular block obtained in 20 patients with major thermal injury after 0.75 mg.kg-1 i.v. of atracurium, by muscular activity recording (train of four-TOF), was studied. The results confirmed the resistance to atracurium, which mechanism is unknown. Even the doses administered, 50% higher than clinical dose (0.3-0.5 mg.kg-1), proved insufficient in order to obtain a complete neuromuscular block in severely burned patients.
D'Eramo
C
C
Servizio di Anestesia e Rianimazione, USL 4, Parma, Italia.
Lombardelli
L
L
Lunardi
S
S
D000328:Adult; D001279:Atracurium / Q000008:administration & dosage*; D002056:Burns / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000502:physiology*; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology
D001279:Atracurium
Grands brûlés et atracurium: réponse au train de quatre.