[Effects of ubiquinone-9 on lipids of nuclei and chromatin of the rat liver under continuous irradiation].
The influence of continuous gamma irradiation on the lipids of nuclei and chromatin of rat liver at a dose-rate of 0,129 Gy/day for 155 days (a total dose of 20 Gy) and by feeding of ubiquinone-9 has been studied. The amount of phosphatidylcholine with phosphatidylserine and phosphatidyl-ethanolamine in liver nuclei of irradiated rats was found to increase. Ubiquinone-9 had a normalizing effect. A decrease of cardiolipin was observed in the liver chromatin of irradiated rats. The amount of free fatty acids had a tendency to decrease in homogenate, nuclei and liver chromatin of irradiated rats. Ubiquinone was found to increase the amount of free fatty acids up to the control level. The amount of cholesterol in nuclei was increased after irradiation and that in chromatin tended to rise. Ubiquinone-9 significantly decreased the amount of cholesterol in nuclei and chromatin of irradiated rats.
Kulagina
T P
TP
Kolomiĭtseva
I K
IK
Obol'nikova
E A
EA
Samokhvalov
G I
GI
Kuzin
A M
AM
D000818:Animals; D002467:Cell Nucleus / Q000737:chemistry* / Q000187:drug effects / Q000528:radiation effects; D002784:Cholesterol / Q000032:analysis / Q000528:radiation effects; D002843:Chromatin / Q000737:chemistry* / Q000187:drug effects / Q000528:radiation effects; D002855:Chromatography, Thin Layer; D005230:Fatty Acids, Nonesterified / Q000032:analysis / Q000528:radiation effects; D066298:In Vitro Techniques; D008055:Lipids / Q000032:analysis* / Q000528:radiation effects; D008099:Liver / Q000187:drug effects* / Q000528:radiation effects*; D008297:Male; D010743:Phospholipids / Q000032:analysis / Q000528:radiation effects; D011829:Radiation Dosage; D051381:Rats; D017208:Rats, Wistar; D014451:Ubiquinone / Q000494:pharmacology*
D002843:Chromatin; D005230:Fatty Acids, Nonesterified; D008055:Lipids; D010743:Phospholipids; D014451:Ubiquinone; D002784:Cholesterol; C030571:ubiquinone 9
Vliianie ubikhinona-9 na lipidy iader i khromatina pecheni krys v usloviiakh khronicheskogo oblucheniia.