[Necrosis of the terminal ileum after drug poisoning. Case report].
In an attempt to commit suicide, a 32-year-old women swallowed a vast amount of psychiatric drugs, i.e. tranquilizers, amphetamines, hynotic and antidepressant agents. By intensive care, using high doses of catecholamines and appropriate antidota, satisfactory circulation and oxygenation could be maintained. 3 days after admission a peritonitis became apparent. A 50 cm long section of the distal ileum was found to be completely necrotic and had to be resected. However, circulation of the correspondent mesenterium was not disturbed at all. A drug-induced non-occlusive intestinal ischemia was postulated to be the pathophysiological mechanism of intestinal necrosis. Non-occlusive intestinal ischemia is rare; it has been reported in young adults intoxicated by cocaine or phenobarbital, in children with high overdosage of iron compounds, in elderly individuals suffering from low-output congestive heart disease and in patients treated with digitalis drugs, with or with or without overdosage.
Meier
L
L
Chirurgische Abteilung, Kreisspital Männedorf.
Hollinger
A
A
Umbricht
R
R
Tamborini
P
P
D000328:Adult; D062787:Drug Overdose / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D007082:Ileum / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D009336:Necrosis; D010538:Peritonitis / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000506:poisoning*; D013406:Suicide, Attempted
D011619:Psychotropic Drugs
Nekrose des terminalen Ileum nach Tablettenintoxikation. Fallbericht.