Late doxorubicin cardiotoxicity.
The occurrence of late congestive heart failure (CHF) as the first clinical manifestation of doxorubicin-induced cardiac toxicity is unusual in children and very rare in adults. However, subclinical cardiac dysfunction is commonly detected in children years after treatment with doxorubicin containing regimens. We report a 58 year old woman who developed stage IV CHF 7 years after completion of doxorubicin treatment for carcinoma of the ovary. Occult cardiac dysfunction was first demonstrated by radionuclide angiography 6 years prior to the occurrence of the clinical manifestations. This unique course of the disease and the management of the CHF are discussed.
Lishner
M
M
Department of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Kfar Saba, Israel.
Elis
A
A
Ravid
M
M
D017023:Coronary Angiography; D004280:Dobutamine / Q000627:therapeutic use; D004317:Doxorubicin / Q000009:adverse effects*; D005260:Female; D006333:Heart Failure / Q000139:chemically induced*; D006801:Humans; D008875:Middle Aged; D013997:Time Factors; D016277:Ventricular Function, Left / Q000187:drug effects
D004280:Dobutamine; D004317:Doxorubicin