Cell-mediated cytotoxicity.
Progress is being made in determining how cytotoxic cells are activated, the way the lethal hit is delivered and the subsequent events in the target cell. Several factors cloud the issue, including the heterogeneity of cytotoxic cells, differences between fresh cells and cell lines, and the possibility of single cells using multiple cytotoxic mechanisms. The most difficult task will be to define which cytotoxic mechanisms are significant in vivo.
Taylor
M K
MK
Department of Microbiology and Immunology, University of Colorado Medical School, Denver 80262.
Cohen
J J
JJ
D000818:Animals; D017209:Apoptosis / Q000276:immunology; D003602:Cytotoxicity, Immunologic / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D016692:Receptors, Antigen, T-Cell, gamma-delta