Displacement of rifampicin bound to serum proteins by addition of levamisole.
We have studied, by ultrafiltration, the interactions between rifampicin (15 and 30 microM) and levamisole (7 microM) since both drugs may be associated for the treatment of brucellosis. We can observe a statistically significant increase in the free plasmatic fraction of rifampicin at the studied concentration of levamisole, which indicated that levamisole reduced rifampicin bound to proteins (290 and 250%, respectively).
Pérez-Gallardo
L
L
Departamento de Bioquímica, Colegio Universitario de Medicina, Soria, Spain.
Blanco
M L
ML
Soria
H
H
Escanero
J F
JF
D001798:Blood Proteins / Q000378:metabolism*; D004347:Drug Interactions; D006801:Humans; D007978:Levamisole / Q000494:pharmacology*; D011485:Protein Binding / Q000187:drug effects; D012293:Rifampin / Q000378:metabolism*
D001798:Blood Proteins; D007978:Levamisole; D012293:Rifampin