title: Distinctive HLA-A,B antigens of black populations formed by interallelic conversion.
abstract: Alleles encoding five HLA-A and B Ag characteristic of black populations have been isolated and their nucleotide sequences determined. In each case, the "black" allele is similar to a "related" allele found in caucasoid populations. The primary differences between these pairs of alleles are localized clusters of nucleotide substitutions that change two to five residues of the Ag recognition site. The pattern of differences indicates that the pairs of black and caucasoid alleles diverged primarily as a result of interallelic conversion events.
authors.affiliation: Department of Cell Biology, Stanford University, CA 94305.
authors.forename: J A
authors.initials: JA
authors.lastname: Madrigal
authors.forename: M P
authors.initials: MP
authors.lastname: Belich
authors.forename: W H
authors.initials: WH
authors.lastname: Hildebrand
authors.forename: R J
authors.initials: RJ
authors.lastname: Benjamin
authors.forename: A M
authors.initials: AM
authors.lastname: Little
authors.forename: J
authors.initials: J
authors.lastname: Zemmour
authors.forename: P D
authors.initials: PD
authors.lastname: Ennis
authors.forename: F E
authors.initials: FE
authors.lastname: Ward
authors.forename: M L
authors.initials: ML
authors.lastname: Petzl-Erler
authors.forename: E D
authors.initials: ED
authors.lastname: du Toit
mesh_terms: D000349:Africa; D000483:Alleles; D000595:Amino Acid Sequence; D044383:Black People / Q000235:genetics*; D005785:Gene Conversion; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D014481:United States; D044465:White People / Q000235:genetics; D001741:Black or African American
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens