Secretion of hyaluronic acid from synovial fibroblasts is enhanced by histamine: a newly observed metabolic effect of histamine.
We obtained evidence for the presence of histamine H1 and H2 receptors in normal synovial fibroblasts. Histamine enhanced proliferation of these synovial fibroblasts and stimulated the release of hyaluronic acid from these tissues. The molecular weight of hyaluronic acid decreased with this stimulation. The release of lower molecular weight hyaluronic acid from the synovium by histamine may be an important factor in joint disease.
Nagata
Y
Y
Department of Orthopaedic Surgery, Kinki University School of Medicine, Osaka, Japan.
Matsumura
F
F
Motoyoshi
H
H
Yamasaki
H
H
Fukuda
K
K
Tanaka
S
S
D000293:Adolescent; D000328:Adult; D002478:Cells, Cultured; D002744:Chlorpheniramine / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008970:Molecular Weight; D011869:Radioligand Assay; D011969:Receptors, Histamine H1 / Q000187:drug effects / Q000378:metabolism; D011970:Receptors, Histamine H2 / Q000187:drug effects / Q000378:metabolism; D013583:Synovial Membrane / Q000187:drug effects / Q000378:metabolism*
D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D002744:Chlorpheniramine; D002927:Cimetidine; D006632:Histamine; D006820:Hyaluronic Acid; D004247:DNA