Granulocyte serology findings in juvenile symptomatic idiopathic autoimmune neutropenia using a multiassay procedure. Report on 21 cases.
The serological findings on 21 children with idiopathic autoimmune neutropenia are reported. A multiassay procedure was adopted including agglutination, immunofluorescence and cytotoxicity tests. Beside a cause-effect correlation between granulocyte antibodies and clinical course, a serologic polymorphism was found. As the sensitivity of each assay seemed to be related to the characteristics of the involved antigens and antibodies, as well as to the intrinsic sensitivity of the tests, the performance of a multiassay procedure appears to be advisable for the diagnosis and the follow-up of autoimmune neutropenia.
Borzini
P
P
Centro Trasfusionale, Ospedale San Gerardo, Monza, Italia.
Assali
G
G
D000372:Agglutination Tests; D001323:Autoantibodies; D001327:Autoimmune Diseases / Q000276:immunology*; D002675:Child, Preschool; D003601:Cytotoxicity Tests, Immunologic; D005455:Fluorescent Antibody Technique; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D007223:Infant; D007519:Isoantigens / Q000276:immunology*; D009503:Neutropenia / Q000209:etiology / Q000276:immunology*
D001323:Autoantibodies; D007519:Isoantigens; C067704:neutrophil-specific antigen NA1, human