Serum gastrin is not higher in subjects with colonic neoplasia.
Two previous studies have shown higher circulating gastrin levels in subjects with colonic neoplasia than in colonoscopy-negative controls. In this much larger study, sera were collected from fasting subjects undergoing colonoscopy. Colonoscopy with biopsy classified participants as having colonic adenomas (N = 139), colon carcinoma (N = 29), or controls without colonic neoplasia (N = 150). Frozen, stored sera were later analyzed for gastrin by radioimmunoassay. Serum gastrin values were no higher in subjects with colonic adenomas or carcinoma than in colonoscopy-negative controls. We conclude that elevated serum gastrin levels play little, if any, role in the initiation of colonic neoplasia.
Kikendall
J W
JW
Department of Medicine, Walter Reed Army Medical Center, Washington, DC.
Glass
A R
AR
Sobin
L H
LH
Bowen
P E
PE
D000230:Adenocarcinoma / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D000236:Adenoma / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D016022:Case-Control Studies; D003110:Colonic Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D003113:Colonoscopy; D005260:Female; D005755:Gastrins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
D005755:Gastrins