title: Single agent high-dose cisplatin (200 mg m-2) treatment in ovarian carcinoma.
abstract: Twenty patients with epithelial ovarian carcinoma were treated with high-dose cisplatin 200mg m-2. Patients were to receive three cycles at 21 day intervals. Treatment was stopped if severe myelosuppression or any neurotoxicity occurred. Overall, eight (40%) of patients responded with a complete response in five (25%). Four of 16 (25%) previously treated patients responded. The median duration of response was 44 weeks (range 6-130). In patients previously treated there was a significant association (P < 0.002) between response and a remission free interval of 52 weeks or more from primary chemotherapy. Toxicity was assessable in 18 patients. Alopecia and nausea/vomiting were common. Myelosuppression was recorded in nine patients delaying planned administration in eight of 35 cycles. Five patients developed anaemia and six thrombocytopenia. Neurotoxicity affected seven patients and varying degrees of tinnitus six patients. Neurotoxicity and myelosuppression were indications for cessation of treatment in 8 patients receiving less than three cycles. Analysis revealed no significant association between toxicity and prior cisplatin exposure, age or the amount of high-dose cisplatin administered. This series reveals that it is possible to achieve good response rates using high-dose cisplatin without encountering debilitating neurotoxicity.
authors.affiliation: CRC Clinical Trials Unit, Queen Elizabeth Medical Centre, Birmingham, UK.
authors.forename: S
authors.initials: S
authors.lastname: Kehoe
authors.forename: C
authors.initials: C
authors.lastname: Redman
authors.forename: R
authors.initials: R
authors.lastname: Varma
authors.forename: J
authors.initials: J
authors.lastname: Buxton
authors.forename: D
authors.initials: D
authors.lastname: Luesley
authors.forename: G
authors.initials: G
authors.lastname: Blackledge
authors.forename: A
authors.initials: A
authors.lastname: Stanley
mesh_terms: D000328:Adult; D000368:Aged; D002945:Cisplatin / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006309:Hearing / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D010051:Ovarian Neoplasms / Q000188:drug therapy*
chemical_list: D002945:Cisplatin