title: Synthesis and biological activity of new 1,8-diaza-2,9,10-anthracenetrione derivatives.
abstract: Diels-Alder heterocycloaddition reactions of 2,5,8-quinolinetriones and 1-azadienes afford 1,8-diaza-2,9,10-anthracenetriones, which are simple analogues of the antitumoral antibiotic diazaquinomicin A. Cytotoxicity in this series and antitumor activity of the lead compound, 6-methyl-1,8-diaza-2,9,10-anthracenetrione, are reported.
authors.affiliation: Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Gesto
authors.forename: E
authors.initials: E
authors.lastname: de la Cuesta
authors.forename: C
authors.initials: C
authors.lastname: Avendaño
authors.forename: F
authors.initials: F
authors.lastname: Emling
mesh_terms: D000873:Anthracenes / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D011809:Quinones / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000873:Anthracenes; D000970:Antineoplastic Agents; D011809:Quinones; C046688:diazaquinomycin A