A theoretical analysis of a new drug delivery system: a cylindrical device with a vertical opening on its surface.
A theoretical analysis of a proposed drug delivery device is presented. The device is of cylindrical shape with an opening on its side surface. Analytical expressions for the temporal variations in the amount of drug released and the size of the unreleased portion of the device are derived. The result of numerical simulation reveals that an approximately zero-order mechanism can be obtained, provided that the device is designed appropriately. The applicability of the analytical expressions derived is justified by examining the release of sodium salicylate embedded in polyethylene. The present work is a generalization of analyses suggested previously for some similar devices.
Hsu
J P
JP
Department of Chemical Engineering, National Taiwan University, Taipei, Republic of China.
Ting
C
C
Lin
M J
MJ
D016503:Drug Delivery Systems; D008433:Mathematics; D008962:Models, Theoretical