[Prostacyclin-thromboxane imbalance after adrenergic damage of the heart and aorta and its correction with calcium antagonist finoptin and the adaptation to high-altitude climate].
Adrenergic cardiac and aortic lesion was reproduced by using intramuscularly a stress-necrogenic epinephrine dose of 2 mg/kg. Following 24 hours, the levels of malonic dialdehyde (MDA) as a TxA2 marker, were measured in the platelets. The antiaggregability of the aortic wall where PGI2 is synthesized was also examined. The adrenergic lesion was found to impair the platelet function-vascular wall balance, creating the condition for enhancing spontaneous platelet aggregation. This led to 50% death of experimental "lowland" rats. The short-term high-altitude adaptation failed to substantially modify the death rates in adrenergic lesion, though the platelets showed a 30% decrease in MDA generation. The combination of high-altitude adaptation and the calcium antagonist finoptin completely prevented the stress-induced increase in the platelet generation of MDA, a TxA2 marker, which was followed by a drastic reduction (16.6% versus 50%) in sudden death cases among the rats during adrenergic cardiac and aortic lesion.
Aliev
M A
MA
Lemeshenko
V A
VA
Bekbolotova
A K
AK
D000222:Adaptation, Physiological; D000531:Altitude; D000818:Animals; D001012:Aorta, Abdominal / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D004837:Epinephrine / Q000008:administration & dosage / Q000009:adverse effects*; D011464:Epoprostenol / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009336:Necrosis; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D013928:Thromboxane A2 / Q000378:metabolism*; D014700:Verapamil / Q000008:administration & dosage*
D013928:Thromboxane A2; D014700:Verapamil; D011464:Epoprostenol; D004837:Epinephrine
Prostatsiklin-tromboksanovyĭ disbalans pri adrenergicheskom povrezhdenii serdtsa i aorty i ego korrektsiia antagonistom kal'tsiia finoptinom i adaptatsieĭ k gornomu klimatu.