[Effects of bonnecor on transmembrane potentials of cardiomyocytes of the ventricular contractile myocardium of the intact heart and ventricular fibrillation].
The microelectrode technique has shown that bonnecor given in a dose of as many as 2 mg/kg increases the action potential amplitude, but when its dose is increased up to 3 mg/kg, the agent decreases the action potential amplitude of ventricular cardiomyocytes in the guinea-pig, the resting potential remaining steady. Administration of bonnecor prevents ventricular fibrillation after aconitine application and provokes ventricular fibrillation and flutter when the focus of ectopic automatism is formed.
Kobrin
V I
VI
Vostrikov
V A
VA
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003984:Dibenzazepines / Q000494:pharmacology* / Q000627:therapeutic use; D004562:Electrocardiography; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects*; D009200:Myocardial Contraction; D009206:Myocardium / Q000166:cytology*; D014693:Ventricular Fibrillation / Q000517:prevention & control*
D000889:Anti-Arrhythmia Agents; D003984:Dibenzazepines; C048166:tiracizine
Vliianie bonnekora na transmembrannye potentsialy kardiomiotsitov sokratitel'nogo miokarda zheludochkov intaktnogo serdtsa i fibrilliatsiiu zheludochkov.