Experimentally induced ameloblastomas: a critical review.
This article reviews the experimental induction of ameloblastomas with emphasis on the acceptability of the induced tumors as being truly equivalent to ameloblastomas in humans. Attempts to induce odontogenic tumors in experimental animals have been made sporadically since the early 1960's but the yield of ameloblastomas has been low. Tumors resembling ameloblastomas, but not completely typical histologically and apparently lacking the invasive qualities of ameloblastoma, have been produced in mice using polyoma virus. However, the most typical ameloblastomas have been those induced in opossums, using ethylnitrosourea. Consequently, it is recommended that this model be used in any further attempts to produce ameloblastomas experimentally.
Gardner
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DG
Division of Oral Pathology and Oncology, University of Colorado School of Dentistry, Denver 80262.
D000564:Ameloblastoma / Q000209:etiology* / Q000473:pathology; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D009374:Neoplasms, Experimental