Comparative bioavailability of two different rectal preparations of piroxicam in man.
A comparative pharmacokinetic study was performed with two types of suppository each containing 20 mg piroxicam. The bioavailability of piroxicam was studied in 24 healthy volunteers in a double blind, randomised, cross over study. No significant difference was found in the pharmacokinetic parameters [AUC(0-72 h), AUC, Cmax, t1/2 beta] calculated from plasma concentration time curves, indicating that the two preparations were bioequivalent.
Benkö
S
S
Department of Pharmacokinetics, EGIS Pharmaceuticals, Budapest, Hungary.
Grézal
G
G
Nagy
E
E
Klebovich
I
I
D000285:Administration, Rectal; D000328:Adult; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D004311:Double-Blind Method; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D010894:Piroxicam / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011897:Random Allocation; D013488:Suppositories
D013488:Suppositories; D010894:Piroxicam