title: A longitudinal study of the effects on the oral mucosa of treatment for acute childhood leukaemia.
abstract: A longitudinal study was undertaken of the effect of therapy on the oral mucosa of 12 children with acute leukaemia. The major oral problem was ulceration, which was associated with neutrophil counts of less than 1.0 x 10(9)/l. Candida carriage rates were consistently high in patients with or without oral candidosis. Salivary flow was not significantly different between leukaemic children and the control group.
authors.affiliation: Community Dental Service, Liverpool Health Authority.
authors.forename: M C
authors.initials: MC
authors.lastname: Williams
authors.forename: M V
authors.initials: MV
authors.lastname: Martin
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D002180:Candidiasis, Oral / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000188:drug therapy; D008137:Longitudinal Studies; D008297:Male; D009059:Mouth Diseases / Q000209:etiology*; D009061:Mouth Mucosa / Q000473:pathology*; D009503:Neutropenia / Q000139:chemically induced / Q000150:complications; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy; D012472:Salivation / Q000187:drug effects; D014456:Ulcer / Q000209:etiology
chemical_list: D000970:Antineoplastic Agents