Fat and gastric acid secretion.
To evaluate the importance of the terminal carboxyl group of the oleic acid molecule in the inhibition of gastric acid secretion, 6 normal persons were stimulated twice with duodenal perfusates containing either 20 mM oleic acid or 20 mM oleyl alcohol. Oleic acid significantly inhibited the gastric acid secretion stimulated by pentagastrin (100 ng/kg/h) and increased the levels of secretin in plasma. The effect of oleyl alcohol was insignificant. It is concluded that the carboxyl group of the fat molecule has an important role in the inhibition of gastric acid secretion, and the effect could in part be attributable to the release of secretin into plasma.
Petersen
F
F
Department of Surgery D, Glostrup Hospital, Denmark.
Olsen
O
O
Jepsen
L V
LV
Christiansen
J
J
D000328:Adult; D004386:Duodenum / Q000187:drug effects; D005233:Fatty Alcohols / Q000494:pharmacology*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019301:Oleic Acid; D009829:Oleic Acids / Q000737:chemistry / Q000494:pharmacology*; D010418:Pentagastrin / Q000494:pharmacology; D010477:Perfusion; D012633:Secretin / Q000097:blood; D013268:Stimulation, Chemical
D005233:Fatty Alcohols; D009829:Oleic Acids; D012633:Secretin; C010268:oleyl alcohol; D019301:Oleic Acid; D010418:Pentagastrin