title: Alkalinization of mepivacaine does not alter onset of caudal anesthesia.
abstract: OBJECTIVE
  To determine the effect of alkalinization of mepivacaine on onset of caudal anesthesia.
  
  
  METHODS
  Randomized, blind study.
  
  
  METHODS
  Colon-Rectal Surgery Service of the Tertiary Center at Cleveland Clinic Foundation.
  
  
  METHODS
  Young, healthy adults undergoing anal surgery.
  
  
  METHODS
  Addition of bicarbonate (study group) or saline (control group) to mepivacaine.
  
  
  RESULTS
  At the onset of sacral anesthesia, demographics were measured. A slightly faster onset was found in the study group (4.28 vs. 6.08 minutes), but this was not statistically significant.
  
  
  CONCLUSIONS
  Alkalinization of mepivacaine does not significantly accelerate the onset of caudal anesthesia.
authors.affiliation: Department of General Anesthesia, Cleveland Clinic Foundation, OH 44195.
authors.forename: J E
authors.initials: JE
authors.lastname: Tetzlaff
authors.forename: L
authors.initials: L
authors.lastname: Rothstein
mesh_terms: D000328:Adult; D000468:Alkalies; D000763:Anesthesia, Caudal / Q000379:methods; D001639:Bicarbonates / Q000008:administration & dosage / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008619:Mepivacaine / Q000008:administration & dosage / Q000737:chemistry*; D009407:Nerve Block; D012447:Sacrum; D013997:Time Factors
chemical_list: D000468:Alkalies; D001639:Bicarbonates; D008619:Mepivacaine