Plasminogen activators and plasminogen activator inhibitor 1 before and after venous occlusion of the upper limb in thromboangiitis obliterans (Buerger's disease).
Plasma levels of plasminogen activators (t-PA, u-PA) and their inhibitor (PAI-1) were studied in patients suffering from Buerger's disease and healthy volunteers before and after 15 minutes of venous occlusion test. The baseline levels of t-PA in group of patients did not differ from those of controls. On the contrary patients with Burger's disease showed a marked increase in u-PA antigen concentrations with concomitant decrease in PAI-1 antigen levels. During venous stasis t-PA antigen concentrations increased in all subjects, however it was much pronounced in controls. Venous occlusion resulted in significant decrease in free PAI-1 levels in the group of patients only. In conclusion, Buerger's disease is associated with the endothelial derangement with increased u-PA release and decreased PAI-1 release, which does not influence the function of fibrinolytic system. The fact that the reduced response of the endothelium to release t-PA after venous stasis goes in parallel with marked decrease in PAI-1 antigen levels seems to suggest that patients suffering from Buerger's disease are not at high risk of intravascular fibrin deposition.
Choudhury
N A
NA
Department of Surgery, Hamamatsu University, School of Medicine, Japan.
Pietraszek
M H
MH
Hachiya
T
T
Baba
S
S
Sakaguchi
S
S
Takada
Y
Y
Takada
A
A
D001132:Arm / Q000098:blood supply; D003250:Constriction; D005342:Fibrinolysis; D006801:Humans; D017395:Plasminogen Activator Inhibitor 1 / Q000032:analysis*; D010960:Plasminogen Activators / Q000032:analysis*; D013919:Thromboangiitis Obliterans / Q000097:blood*; D014680:Veins
D017395:Plasminogen Activator Inhibitor 1; D010960:Plasminogen Activators