title: Pharmacokinetics and metabolism of [3H]-pipethiaden in healthy volunteers.
abstract: Six healthy volunteers participated in a single-dose study of pharmacokinetics and metabolism of oral administration of [3H]-pipethiaden (1 mg). Plasma levels of total radioactivity, urinary excretion and metabolism were analyzed by liquid scintillation counting and radio-TLC. The mean peak plasma concentration of radioactive metabolites was 4.9 ng eq/ml, and the mean elimination half life was 11.5 h. 34% of radioactivity was recovered in 4 days in urine, with only 0.4% present as unchanged drug. Pipethiaden was extensively metabolized by S-oxidation, N-demethylation, and N-oxidation.
authors.affiliation: Research Institute for Pharmacy and Biochemistry, Prague, Czechoslovakia.
authors.forename: Z
authors.initials: Z
authors.lastname: Plecitá
authors.forename: M
authors.initials: M
authors.lastname: Spanĕl
authors.forename: I
authors.initials: I
authors.lastname: Ulc
authors.forename: V
authors.initials: V
authors.lastname: Rejŏlec
authors.forename: R
authors.initials: R
authors.lastname: Lapka
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000493:pharmacokinetics*; D014316:Tritium
chemical_list: D010880:Piperidines; D014316:Tritium; C045300:pipethiaden