Significance of serum sialic acid in patients with Crohn's disease.
Serum sialic acid was measured to evaluate the activity of Crohn's disease. The sialic acid levels of patients with Crohn's disease in remission (CRP 0.0 mg/dl) were significantly higher than those of healthy subjects and postoperative patients with Crohn's disease. In patients in remission, serum sialic acid was significantly correlated with hemoglobin, hematocrit, platelet, and rapid turnover protein. Correlations with platelet, retinol-binding protein, and prealbumin were especially strong. From these findings, it was concluded that serum sialic acid level provides a useful index of the activity of Crohn's disease.
Baba
R
R
Institute of Gastroenterology, Tokyo Women's Medical College, Japan.
Yashiro
K
K
Nagasako
K
K
Obata
H
H
D000328:Adult; D000704:Analysis of Variance; D002097:C-Reactive Protein / Q000032:analysis; D003424:Crohn Disease / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D019158:N-Acetylneuraminic Acid; D010976:Platelet Count; D011228:Prealbumin / Q000032:analysis; D012177:Retinol-Binding Proteins / Q000032:analysis; D012709:Serum Albumin / Q000032:analysis; D012794:Sialic Acids / Q000097:blood*
D006454:Hemoglobins; D011228:Prealbumin; D012177:Retinol-Binding Proteins; D012709:Serum Albumin; D012794:Sialic Acids; D002097:C-Reactive Protein; D019158:N-Acetylneuraminic Acid