[A case of acetaminophen-induced pneumonitis].
A 20-year-old woman took 1.2 g of acetaminophen for toothache. She subsequently developed a dry cough, pyrexia, and dyspnea. Chest X-ray revealed diffuse reticulo-nodular shadows in both lung fields. Broncho-alveolar lavage examination showed a marked increase in the total cell number and an increase in the percentage of eosinophils, neutrophils, and lymphocytes. Because drug-induced pneumonitis was suspected, all drugs were stopped and she was administered methylprednisolone. Consequently her symptoms resolved, and pulmonary function and chest X-ray findings improved remarkably. The lymphocyte stimulation test was positive for Norshin and its acetaminophen element. Based on these findings, the diagnosis of acetaminophen-induced pneumonitis was made. Acetaminophen intoxication is well-known, but to our knowledge this is the first reported case of acetaminophen-induced allergic pneumonitis in Japan.
Kitaguchi
S
S
Department of Internal Medicine, Hiroshima City Hospital, Japan.
Miyazawa
T
T
Minesita
M
M
Doi
M
M
Takahashi
K
K
Yamakido
M
M
D000082:Acetaminophen / Q000009:adverse effects*; D000328:Adult; D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced*; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans
D000082:Acetaminophen