The effect of dietary factors on intradentinal dye penetration in the rat.
Fluorescent dye injected systemically into rats penetrated the dentinal tubules of molar teeth in a dynamic fashion. The presence of dye was established using histological and fluorescence microscopy techniques. The rate of intradentinal dye penetration was dependent on dietary factors: it was high in rats chronically fed Purina rat chow and low in rats fed a cariogenic, high-sucrose diet. In addition, parotidectomized rats showed low levels of intradentinal dye penetration, even though they were maintained on Purina chow. One and 2 ml of plasma from Purina-fed rats were effective in stimulating the dye penetration in intact and parotidectomized rats, whereas 2 and 4 ml of plasma from rats fed a high-sucrose diet were ineffective when infused in either intact or parotidectomized animals. The results suggest that rats fed Purina chow have a significantly higher titre of a circulating, dye penetration stimulating factor than animals fed a high sucrose diet. This circulating factor could be the equivalent of the parotid hormone isolated from porcine tissue. It is suggested that dietary factors may affect secretion of a parotid hormone and thereby regulate the rate of dentinal fluid movement. There is therefore the prospect of a functional relationship between diet, the regulation of dentinal fluid flow by an endocrine system and dental health.
Leonora
J
J
Department of Physiology, School of Medicine, Loma Linda University, CA 92350.
Tieche
J M
JM
Steinman
R R
RR
D000167:Acriflavine / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D000818:Animals; D001810:Blood Volume; D003804:Dentin / Q000187:drug effects / Q000378:metabolism*; D003806:Dentin Permeability; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D010306:Parotid Gland / Q000502:physiology* / Q000601:surgery; D010949:Plasma; D051381:Rats; D017207:Rats, Sprague-Dawley; D013395:Sucrose / Q000494:pharmacology*
D004040:Dietary Carbohydrates; D000167:Acriflavine; D013395:Sucrose