title: SEA syndrome revisited: a longterm followup of children with a syndrome of seronegative enthesopathy and arthropathy.
abstract: Thirty-six of the 39 children originally described with the syndrome of seronegative enthesopathy and arthropathy, followed for a mean of 11 years after symptom onset, were found to have had a widely varied clinical course. Twelve of the 23 patients (52%) who originally did not have a seronegative spondyloarthropathy developed definite (6) or possible (6) seronegative spondyloarthropathies. The development of a seronegative spondyloarthropathy was associated with HLA-B27 (p = 0.0004) and the presence of arthritis (rather than arthralgia only) at the time of the original report (p = 0.05). For patients with arthritis, the development of a seronegative spondyloarthropathy was associated with arthritis onset after 5 years of age (p = 0.01).
authors.affiliation: Department of Paediatrics, University of British Columbia, Vancouver, Canada.
authors.forename: D A
authors.initials: DA
authors.lastname: Cabral
authors.forename: K G
authors.initials: KG
authors.lastname: Oen
authors.forename: R E
authors.initials: RE
authors.lastname: Petty
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D015984:Causality; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D015796:HLA-B27 Antigen / Q000032:analysis; D006801:Humans; D007223:Infant; D007592:Joint Diseases / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D008297:Male; D009140:Musculoskeletal Diseases / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D012307:Risk Factors; D013167:Spondylitis, Ankylosing / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology; D013577:Syndrome
chemical_list: D015796:HLA-B27 Antigen