title: Diagnostic problems with meningococcal disease in general practice.
abstract: Based on general practitioners' referral letters and hospital records, we made a retrospective analysis of a cohort of 177 consecutive cases of meningococcal disease that occurred during a period of 10 years in the County of North Jutland, Denmark. The analysis concerned diagnostic problems in general practice, prognosis, pre-hospital antibiotic treatment and its effect on subsequent cultures, and degree of obligatory notification. The referring doctor suspected meningococcal disease/central nervous infection in 123 patients (69.5%). Neck stiffness and petechiae were related to a correct referral diagnosis, in contrast to the occurrence of a non-petechial rash. The presence of disseminated intravascular coagulation was associated with the mortality rate, which was 0.062. The therapeutic recommendations of the Danish Health Authorities were followed in only 25 of the 98 patients who fulfilled the criteria for pre-hospital parenteral antibiotic treatment. Pre-hospital antibiotic treatment was related to negative culture of spinal fluid or blood. Seven of the 177 patients were not notified according to the rules. Difficulties in pre-hospital diagnosis seem not to influence the lethal course of the disease.
authors.affiliation: Medical Department M, Aalborg Hospital, Denmark.
authors.forename: H T
authors.initials: HT
authors.lastname: Sørensen
authors.forename: J
authors.initials: J
authors.lastname: Møller-Petersen
authors.forename: H B
authors.initials: HB
authors.lastname: Krarup
authors.forename: H
authors.initials: H
authors.lastname: Pedersen
authors.forename: H
authors.initials: H
authors.lastname: Hansen
authors.forename: H
authors.initials: H
authors.lastname: Hamburger
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002985:Clinical Protocols / Q000592:standards; D003718:Denmark / Q000453:epidemiology; D004211:Disseminated Intravascular Coagulation / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D004632:Emergency Medical Services / Q000592:standards / Q000706:statistics & numerical data; D005194:Family Practice / Q000592:standards* / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007223:Infant; D016015:Logistic Models; D008297:Male; D008585:Meningitis, Meningococcal / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D008875:Middle Aged; D010818:Practice Patterns, Physicians' / Q000592:standards* / Q000706:statistics & numerical data; D011237:Predictive Value of Tests; D011379:Prognosis; D012017:Referral and Consultation / Q000706:statistics & numerical data; D012703:Serotyping; D015996:Survival Rate
chemical_list: D000900:Anti-Bacterial Agents