[The direct measurement of the spin-grid-relaxation times of phosphorus metabolites in the human myocardium].
The T1 relaxation times of the phosphorus metabolites in human heart muscle measurable by 31P-MR spectra were determined in 12 individuals using a 1.5 Tesla system. Several spectra were recorded consecutively with a pulse repetition time of 1.6 s to 24 s. The T1 times of creatine phosphate (CP), of gamma-, alpha-, beta-adenosintriphosphate (ATP), 2,3-diphosphoglycerate (2,3-DPG) together with anorganic phosphate) and phosphodiester (PDE) showed mean measurements of 6.1 +/- 0.5, 5.4 +/- 0.5, 5.0 +/- 0.5, 5.8 +/- 1.0, 7.6 +/- 1.0, and 5.0 +/- 1.0 s (M +/- SE). The accuracy of the ISIS technique was tested with a special phantom. T1 times were also measured in standard solutions (20 mM CP, 10 mM ATP); CP was 8.7 +/- 0.2 s and gamma-ATP was 9.9 +/- 0.7 s. Corrections for partially saturated 31P-MR spectra--at least for CP/ATP ratios--are relatively small.
Schindler
R
R
Institut für Röntgendiagnostik, Universität Würzburg.
Krahe
T
T
Neubauer
S
S
Hillenbrand
H
H
Entzeroth
C
C
Horn
M
M
Lackner
K
K
Ertl
G
G
D019794:2,3-Diphosphoglycerate; D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D004163:Diphosphoglyceric Acids / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D008961:Models, Structural; D009206:Myocardium / Q000378:metabolism*; D010755:Organophosphates / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism*; D010761:Phosphorus Radioisotopes; D013997:Time Factors
D004163:Diphosphoglyceric Acids; D010755:Organophosphates; D010761:Phosphorus Radioisotopes; D010725:Phosphocreatine; D019794:2,3-Diphosphoglycerate; D010758:Phosphorus; D000255:Adenosine Triphosphate
Direkte Messung der Spin-Gitter-Relaxationszeiten von Phosphormetaboliten im menschlichen Myokard.