title: Prevalence and clinical picture of IDDM in Nigerian Igbo schoolchildren.
abstract: OBJECTIVE
  To evaluate the prevalence and clinical picture of IDDM in Nigerian Igbo schoolchildren born and living in continental Africa.
  
  
  METHODS
  In three school districts (Ezza, Ishielu, Ohaukwu), 77,862 schoolchildren aged 5-17 yr answered our questionnaires on age, sex, known disease, drugs being taken, family history, and diabetic symptoms like polyuria, polydipsia, polyphagia, and weight loss. Positive respondents were given glucosuric tests, and glucosuric subjects had hyperglycemic tests. Diagnosis of IDDM was established in hyperglycemic patients by referred hospital clinicians based on insulin requirements.
  
  
  RESULTS
  Twelve new cases of IDDM were found in addition to 14 previously diagnosed cases, giving a CPR of 0.33/1000. Ishielu had a CPR of 0.46/1000 compared with 0.25 (P less than 0.01) for Ohaukwu. Boys had a CPR of 0.38/1000 compared with 0.25/1000 (P less than 0.06) for girls. Boy-to-girl prevalence ratio was approximately 3:1.
  
  
  CONCLUSIONS
  The relatively high prevalence of IDDM in this poor African population, despite potential deaths caused by minimal medical attention, may be because of long-term protein malnutrition and endemic childhood infections, which have been implicated in the etiology of IDDM in similar malnourished populations.
authors.affiliation: Department of Pediatrics, Faculty of Health Sciences, Linkoping University, Sweden.
authors.forename: A O
authors.initials: AO
authors.lastname: Afoke
authors.forename: N M
authors.initials: NM
authors.lastname: Ejeh
authors.forename: E N
authors.initials: EN
authors.lastname: Nwonu
authors.forename: C O
authors.initials: CO
authors.lastname: Okafor
authors.forename: N J
authors.initials: NJ
authors.lastname: Udeh
authors.forename: J
authors.initials: J
authors.lastname: Ludvigsson
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology*; D005260:Female; D006029:Glycosuria; D006801:Humans; D008297:Male; D009549:Nigeria / Q000453:epidemiology; D015995:Prevalence; D012727:Sex Characteristics; D011795:Surveys and Questionnaires
chemical_list: D001786:Blood Glucose