[Antioxidant effects of antihypoxic drugs in cerebral ischemia].
Cerebral ischemia in rats (both carotid arteries occlusion) during 30 min, 3 hours and recirculation (1 hour) after ischemia (30 min) stimulated diene conjugates and fluorescent products accumulation in brain tissue. Intraperitoneal injection of sodium hydroxybutyrate (100 mg/kg), bemitil (50 mg/kg), ethomersol (50 mg/kg) reduced brain lipid peroxidation and did not yield in this respect to emoxypin (5 mg/kg). In contrast to emoxypin, sodium hydroxybutyrate, bemitil and ethomersol had no antiradical activity.
Plotnikov
M B
MB
Kobzeva
E A
EA
Plotnikova
T M
TM
D000818:Animals; D000975:Antioxidants; D001157:Arterial Occlusive Diseases / Q000188:drug therapy; D001562:Benzimidazoles / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000188:drug therapy*; D002340:Carotid Artery Diseases / Q000188:drug therapy; D010847:Picolines / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012978:Sodium Oxybate / Q000627:therapeutic use*
D000975:Antioxidants; D001562:Benzimidazoles; D010847:Picolines; C070941:ethomersol; C049825:bemethyl; D012978:Sodium Oxybate; C009820:6-methyl-2-ethyl-3-hydroxypyridine
Antiokislitel'nye éffekty antigipoksantov pri ishemii mozga.