Immunogenicity of combined anti-HIV and anti-suppressive vaccine preparations.
HIV-1 antigens generate in man both a humoral and cellular immune reaction. However, in ARC/AIDS patients, the cellular response is inhibited by HIV-1 which induces an antiproliferative (suppressive) effect on activated T cells. To overcome this inhibition and up-regulate the cellular response, we designed a new vaccine strategy directed both against HIV-1 and immunosuppression and we used an immunizing preparation composed of HIV-1 antigens combined with immunoregulatory peptides prepared in a biologically inactivated but immunogenic form. In mice, this preparation induced anti-HIV-1 antibodies and a cell-mediated cytotoxicity directed against H2 restricted cells carrying HIV-1 antigens.
Carelli
C
C
INSERM U36, Paris, France.
Halbreich
A
A
Bernard
J
J
Bizzini
B
B
Achour
A
A
Zagury
J F
JF
Lebon
P
P
Polliotti
B
B
Folghera
S
S
Laaroubi
K
K
D000818:Animals; D004338:Drug Combinations; D005260:Female; D006678:HIV / Q000276:immunology*; D015488:HIV Antigens / Q000008:administration & dosage; D007165:Immunosuppression Therapy / Q000379:methods*; D051379:Mice; D008807:Mice, Inbred BALB C; D010455:Peptides / Q000008:administration & dosage; D014765:Viral Vaccines / Q000276:immunology*
D004338:Drug Combinations; D015488:HIV Antigens; D010455:Peptides; D014765:Viral Vaccines