Effect of extracorporeal shockwave lithotripsy for urolithiasis on concentrations of creatine kinase isozymes in patient serum and urine.
To determine whether extracorporeal shockwave lithotripsy (ESWL) for urolithiasis causes renal injury, we immunoassayed creatine kinase isozymes (CK-B and CK-M) in serum and urine from patients with renal stone (n = 21) and ureteral stone (n = 18) before and after (0, 2, and 24 h) ESWL. CK-B is generally present in renal tissue at relatively high concentrations, whereas CK-M is found at low concentrations. CK-B and CK-M levels were enhanced both in the serum and urine samples after ESWL in both groups of patients but CK-B levels return to almost normal very rapidly. Because CK-M, which is mainly localized in muscle tissue, also increased in both groups, the increased CK-B in serum after ESWL might be derived not only from kidney but also from muscle tissues which also contain a significant level of CK-B. These results suggest that significant tissue injury, including kidney and muscles, might be caused by ESWL treatment for urolithiasis but there is no long-term renal adverse effect, and that creatine kinase isozymes in serum and urine might be useful markers of tissue injury by such treatment.
Hasegawa
S
S
Department of Urology, Nagoya University School of Medicine, Japan.
Kato
K
K
Takashi
M
M
Zhu
Y
Y
Yokoi
K
K
Kobayashi
H
H
Ando
T
T
Obata
K
K
Kondo
A
A
Miyake
K
K
D000328:Adult; D000368:Aged; D003402:Creatine Kinase / Q000378:metabolism*; D005260:Female; D006801:Humans; D007527:Isoenzymes; D007669:Kidney Calculi / Q000378:metabolism* / Q000628:therapy; D008096:Lithotripsy; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D013997:Time Factors; D014514:Ureteral Calculi / Q000378:metabolism* / Q000628:therapy
D007527:Isoenzymes; D003402:Creatine Kinase