title: Structure activity relationships of stendomycin, a lipopeptide antibiotic from Streptomyces.
abstract: A strain of Streptomyces which produced stendomycin, a lipopeptide antibiotic, was grown in culture media containing various amino acids as nitrogen substrates. The nature of the fatty acid component of stendomycin was dependent on the nature of the amino acid present in the medium, but this did not affect antibiotic activity. Modifications in the peptide moiety resulted in a loss of antifungal activity.
authors.affiliation: Laboratoire de Biochimie Microbienne, Université Claude Bernard, Lyon I, Villeurbanne, France.
authors.forename: B
authors.initials: B
authors.lastname: Losilla
authors.forename: M T
authors.initials: MT
authors.lastname: Pommier
authors.forename: N
authors.initials: N
authors.lastname: Bonnaveiro
authors.forename: A
authors.initials: A
authors.lastname: Cremieux
authors.forename: G
authors.initials: G
authors.lastname: Michel
mesh_terms: D000596:Amino Acids; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides; D005227:Fatty Acids / Q000032:analysis; D008055:Lipids; D009584:Nitrogen / Q000378:metabolism; D010452:Peptide Biosynthesis; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D013302:Streptomyces / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D000596:Amino Acids; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D023181:Antimicrobial Cationic Peptides; D005227:Fatty Acids; D008055:Lipids; D010455:Peptides; C002102:stendomycin; D009584:Nitrogen