title: Radial diffusion coefficient mapping.
abstract: The two-dimensional mapping of the effective diffusion coefficient of water in tissues may provide a useful method of tissue characterization to complement T1 and T2 relaxation time studies for diagnostic purposes. Current diffusion techniques rely on the application of large gradient strengths and long echo times to achieve the required sensitivity. This, in turn, limits the applicability of the technique to tissues having long T2s with rapid water diffusion. In addition, the inherent directionality of these methods results in only the partial encoding of diffusion information. A modified diffusion sequence is presented, radial diffusion mapping (RAD), which provides enhanced sensitivity diffusion maps by employing gradient sensitization in three orthogonal directions. Results in both phantoms and volunteers are presented, together with an investigation of the effects of T2 on the measurement accuracy. Using RAD, a two- to five-fold improvement in sensitivity was achieved, thus significantly enhancing the dynamic range of the method and allowing more accurate in vivo diffusion measurements to be carried out.
authors.affiliation: Joint Department of Physics, Institute of Cancer Research, Sutton, Surrey, UK.
authors.forename: A
authors.initials: A
authors.lastname: Madden
authors.forename: M O
authors.initials: MO
authors.lastname: Leach
mesh_terms: D000096:Acetone; D001921:Brain / Q000033:anatomy & histology; D003510:Cyclohexanes; D004058:Diffusion; D004121:Dimethyl Sulfoxide; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008433:Mathematics; D008954:Models, Biological; D008961:Models, Structural; D014867:Water
chemical_list: D003510:Cyclohexanes; D014867:Water; D000096:Acetone; D004121:Dimethyl Sulfoxide