title: A preliminary evaluation of the use of a redox agent in the treatment of chronic periodontitis.
abstract: A small-scale clinical trial was carried out to evaluate the effect of a redox agent, methylene blue, on microbiological and clinical indices of chronic periodontitis. Methylene blue was applied subgingivally on a daily basis for 7 d to 25 test sites in 7 patients and the sites evaluated clinically and microbiologically for up to 14 d: 25 control sites in the same patients received sterile water. The test sites showed statistically significant differences from the control sites in terms of changes in a number of clinical and microbiological indices. In the test sites the proportions of anaerobes, Gram-negative anaerobes, spirochetes and motile bacteria decreased, as did the crevicular fluid flow, while the proportions of facultative anaerobes and cocci increased. These changes are indicative of a shift towards periodontal health. No significant differences were observed between the test and control sites in terms of bleeding on probing or pocket depth. The encouraging results of this preliminary study suggest that the use of redox agents in the treatment of chronic periodontitis warrants further investigation.
authors.affiliation: Department of Clinical Pathology and Immunology, Institute of Dental Surgery, London, U.K.
authors.forename: M
authors.initials: M
authors.lastname: Wilson
authors.forename: M
authors.initials: M
authors.lastname: Gibson
authors.forename: D
authors.initials: D
authors.lastname: Strahan
authors.forename: W
authors.initials: W
authors.lastname: Harvey
mesh_terms: D000328:Adult; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D016009:Chi-Square Distribution; D002908:Chronic Disease; D015169:Colony Count, Microbial; D005260:Female; D005883:Gingival Crevicular Fluid; D006801:Humans; D008297:Male; D008751:Methylene Blue / Q000627:therapeutic use*; D008875:Middle Aged; D016877:Oxidants / Q000627:therapeutic use*; D010084:Oxidation-Reduction; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000382:microbiology; D010518:Periodontitis / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000891:Anti-Infective Agents, Local; D016877:Oxidants; D008751:Methylene Blue