title: Late doxorubicin cardiotoxicity.
abstract: The occurrence of late congestive heart failure (CHF) as the first clinical manifestation of doxorubicin-induced cardiac toxicity is unusual in children and very rare in adults. However, subclinical cardiac dysfunction is commonly detected in children years after treatment with doxorubicin containing regimens. We report a 58 year old woman who developed stage IV CHF 7 years after completion of doxorubicin treatment for carcinoma of the ovary. Occult cardiac dysfunction was first demonstrated by radionuclide angiography 6 years prior to the occurrence of the clinical manifestations. This unique course of the disease and the management of the CHF are discussed.
authors.affiliation: Department of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Kfar Saba, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Lishner
authors.forename: A
authors.initials: A
authors.lastname: Elis
authors.forename: M
authors.initials: M
authors.lastname: Ravid
mesh_terms: D017023:Coronary Angiography; D004280:Dobutamine / Q000627:therapeutic use; D004317:Doxorubicin / Q000009:adverse effects*; D005260:Female; D006333:Heart Failure / Q000139:chemically induced*; D006801:Humans; D008875:Middle Aged; D013997:Time Factors; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D004280:Dobutamine; D004317:Doxorubicin