Mapping of the trichohyalin gene: co-localization with the profilaggrin, involucrin, and loricrin genes.
The chromosomal location of the gene encoding the human hair follicle protein trichohyalin has been determined by in situ hybridization. The human gene has been localized to the region 1q21.1-1q23 (probably 1q21.3) using a sheep trichohyalin cDNA probe. The genes encoding three other epithelial proteins, namely, profilaggrin, involucrin, and loricrin, are also located in the same region of chromosome 1, which, together with their similar gene and protein structures, suggests that the four proteins form a novel superfamily of epithelial structural proteins.
Fietz
M J
MJ
Department of Biochemistry, University of Adelaide, Australia.
Rogers
G E
GE
Eyre
H J
HJ
Baker
E
E
Callen
D F
DF
Sutherland
G R
GR
D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D000091344:Filaggrin Proteins; D006801:Humans; D017403:In Situ Hybridization; D007381:Intermediate Filament Proteins / Q000235:genetics*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008677:Metaphase; D011498:Protein Precursors / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins; D008565:Membrane Proteins; D011498:Protein Precursors; C064554:loricrin; C016159:trichohyalin; C032253:involucrin