High-dose fluoxetine in the treatment of depressed patients not responsive to a standard dose of fluoxetine.
In a four-week, open label study of major depression, 15 patients who had failed to respond to a trial of fluoxetine 20 mg/day of 8-12 weeks duration were then treated with fluoxetine 40 mg/day for one week and then, if tolerated, with either 60 or 80 mg/day. The mean HAM-D-17 and CGIS scores of these 15 patients decreased significantly at the end of 4 weeks on a higher dosage of fluoxetine (60 or 80 mg/day) with respect to the beginning of the four-week study. No significant side-effects were noted.
Fava
M
M
Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114.
Rosenbaum
J F
JF
Cohen
L
L
Reiter
S
S
McCarthy
M
M
Steingard
R
R
Clancy
K
K
D000293:Adolescent; D000328:Adult; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005473:Fluoxetine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged
D005473:Fluoxetine