A randomized clinical trial of mifepristone (RU486) for induction of delayed menses: efficacy and acceptability.
Mifepristone (RU486) should be useful for inducing menstrual bleeding in women with menses delayed up to 10 days. We evaluated this potential use for "menstrual regulation" in a randomized clinical trial with 16 women, half of whom received a single 600 mg dose and half of whom received a placebo. Four of eight women in each treatment group proved to be pregnant. Seven of eight who received mifepristone were not pregnant at two-week follow-up, in contrast to four of eight who received the placebo (p = 0.15). Mifepristone may hold promise for "menstrual regulation" for women who do not have access to medical confirmation of pregnancy or who choose not to have this determination made.
Grimes
D A
DA
Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles.
Mishell
D R
DR
David
H P
HP
D000028:Abortion, Induced / Q000379:methods* / Q000523:psychology; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008598:Menstruation / Q000187:drug effects*; D015735:Mifepristone; D017060:Patient Satisfaction; D011247:Pregnancy; D011261:Pregnancy Trimester, First
D015735:Mifepristone