Myelofibrosis and systemic lupus erythematosus: reversal of fibrosis with high-dose corticosteroid therapy.
A case of myelofibrosis in association with systemic lupus erythematosus (SLE) is reported. Acute thrombocytopenia and a bleeding tendency developed in a 24-year-old woman with SLE. Bone marrow aspiration was unsuccessful due to myelofibrosis. Pulse therapy with methylprednisolone reversed both thrombocytopenia and myelofibrosis. A review of the literature revealed that the coexistence of SLE and myelofibrosis is a rare occurrence. Only 7 cases, to our knowledge, have ever been reported in detail. The present case is the 3rd in which myelofibrosis was reversed by corticosteroids.
Inoue
Y
Y
Third Department of Internal Medicine, Yamaguchi University School of Medicine, Japan.
Matsubara
A
A
Okuya
S
S
Okafuji
K
K
Kaku
K
K
Kaneko
T
T
D000328:Adult; D000740:Anemia / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D005260:Female; D006474:Hemorrhagic Disorders / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008775:Methylprednisolone / Q000008:administration & dosage*; D055728:Primary Myelofibrosis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D013921:Thrombocytopenia / Q000188:drug therapy / Q000209:etiology / Q000473:pathology
D008775:Methylprednisolone