title: Lack of relation between fetal blood gases and fetal blood flow velocity waveform indices found in rhesus isoimmunised pregnancies.
abstract: OBJECTIVE
  To investigate the relation between umbilical vein blood gas components and the vascular resistance in four fetal arteries in Rh-immunised pregnancies.
  
  
  METHODS
  A prospective observational study over a 4-month period.
  
  
  METHODS
  King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
  
  
  METHODS
  Fifteen Rh-isoimmunised pregnant women.
  
  
  METHODS
  Pulsed Doppler examinations of the umbilical artery, fetal internal carotid artery, thoracic aorta and abdominal aorta before transabdominal fetal blood sampling from the umbilical vein on 38 occasions.
  
  
  METHODS
  Doppler flow velocity pulsatility index (PI), systolic/diastolic ratio (A/B) and resistance index (RI) in the four fetal arteries investigated were related to the umbilical vein blood gases and acid-base status (PO2, PCO2, O2-content, CO2-content, HCO3, base excess and lactate concentration).
  
  
  RESULTS
  There were no correlations between the Doppler indices in any of the vessels studied and the blood gases components in the umbilical vein. The ratios between the corresponding Doppler indices in the different vessels were also independent of the blood gases and acid-base status and there were no significant differences in the Doppler indices in the same vessel between fetuses with blood gas values over the 75th centile and those with values below the 25th centile.
  
  
  CONCLUSIONS
  This study does not support a reduction in peripheral vascular resistance in the fetal cerebrum in relation to fetal hypoxia in Rh-immunized pregnancies.
authors.affiliation: Department of Obstetrics and Gynaecology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
authors.forename: J
authors.initials: J
authors.lastname: Legarth
authors.forename: G
authors.initials: G
authors.lastname: Lingman
authors.forename: M
authors.initials: M
authors.lastname: Stangenberg
authors.forename: F
authors.initials: F
authors.lastname: Rahman
mesh_terms: D001783:Blood Flow Velocity; D001785:Blood Gas Monitoring, Transcutaneous; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D011247:Pregnancy; D011446:Prospective Studies; D012203:Rh Isoimmunization / Q000097:blood / Q000503:physiopathology*; D014465:Ultrasonics; D014471:Umbilical Veins; D014655:Vascular Resistance