title: Augmentation of valproate with lithium in a case of rapid cycling affective disorder.
abstract: Rapid cycling affective disorder is characteristically unresponsive to conventional interventions. In bipolar rapid cycling affective disorder, the manic episodes may be controlled with either neuroleptics or electroconvulsive therapy, but the depressive episodes are highly intractable. This report describes the successful treatment of a patient with a bipolar rapid cycling affective disorder using a combination of valproic acid and lithium carbonate.
authors.affiliation: Mood Disorders Unit, London Psychiatric Hospital, Ontario.
authors.forename: V
authors.initials: V
authors.lastname: Sharma
authors.forename: E
authors.initials: E
authors.lastname: Persad
mesh_terms: D000368:Aged; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006760:Hospitalization; D006801:Humans; D016651:Lithium Carbonate / Q000008:administration & dosage*; D014635:Valproic Acid / Q000008:administration & dosage*
chemical_list: D016651:Lithium Carbonate; D014635:Valproic Acid