[Changes in cellular radiosensitivity by modifying the cytoplasmic membranes].
The radiosensitivity of mouse myeloma and E. coli cells in the presence of Mg2+ and UO2(2+) ions has been investigated. It has been shown that Mg2+ ions (10(-4) M) do not influence the viability of E. coli and mouse myeloma cells. The presence of Mg2+ ions during irradiation reduces the survival rate of E. coli cells, but the addition of Mg2+ ions after irradiation does not influence the radiosensitivity of E. coli cells. Comparison of the results on the influence of Mg2+ ions upon cells and bilayer lipid membranes (BLM) permits us to suppose that Mg2+ ions increase the positive charge of the membranes thus promoting the increase in the number of short-lived radiolysis products which impair membranes and increase cell radiosensitivity. UO2(2+) ions (10(-4) M) increase the radioresistance of E. coli cells which can be associated with the increase in the lateral membrane viscosity, as it was shown in the studies on BLM.
Iarova
M S
MS
Pribush
A G
AG
Fedorova
L I
LI
Abidor
I G
IG
Petrov
A N
AN
Kulikov
A V
AV
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000528:radiation effects*; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004926:Escherichia coli / Q000187:drug effects / Q000528:radiation effects; D008051:Lipid Bilayers / Q000528:radiation effects; D008274:Magnesium / Q000494:pharmacology; D008563:Membrane Lipids / Q000528:radiation effects; D051379:Mice; D009101:Multiple Myeloma; D011836:Radiation Tolerance; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000528:radiation effects; D014501:Uranium / Q000494:pharmacology; D017974:Uranium Compounds
D008051:Lipid Bilayers; D008563:Membrane Lipids; D017974:Uranium Compounds; D014501:Uranium; D008274:Magnesium; C012597:uranium dioxide
Izmenenie radiochuvstvitel'nosti kletok putem modifikatsii tsitoplazmaticheskikh membran.