Vasoconstrictor activity of 8-O-acetylharpagide from Ajuga reptans.
The traditional therapeutic indications for the use of Ajuga reptans (Labiatae) have been investigated. The H2O-soluble part of a crude and partially purified MeOH extract and two isolated iridoids (8-O-acetylharpagide and harpagide), were tested for a biological activity on isolated smooth muscle preparations from guinea pig.
Breschi
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Istituto Policattedra di Discipline Biologiche, Facoltà di Farmacia, Università di Pisa, Italy.
Martinotti
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Catalano
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Flamini
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Morelli
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Pagni
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D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D003106:Colon / Q000187:drug effects; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D010936:Plant Extracts / Q000032:analysis; D010946:Plants, Medicinal / Q000737:chemistry*; D011714:Pyrans / Q000737:chemistry / Q000494:pharmacology*; D014662:Vasoconstrictor Agents / Q000737:chemistry / Q000494:pharmacology*
D010936:Plant Extracts; D011714:Pyrans; D014662:Vasoconstrictor Agents; C077626:8-O-acetylharpagide