[Prolonged action of tuftsin in penicillin epilepsy].
The free behaviour experiments on rats showed during the first day the tuftsin-induced (0.3 mg/kg i. p.) increment of epileptic discharge in all the structures simultaneously. Open field behaviour depended on the sequence of penicillin and tuftsin injections. The rats with tuftsin used after the epileptiformic activity has been developed showed the behaviour analogical to the penicillin-injected animals. The preventive injections of tuftsin resulted in restoration of all behavioural indications by the third day. The optimal corrective effect has been obtained with tuftsin used preventively.
Popova
N S
NS
Butenko
O B
OB
Adrianov
O S
OS
Veskov
R
R
D000818:Animals; D001921:Brain / Q000187:drug effects; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced* / Q000503:physiopathology; D010406:Penicillins; D051381:Rats; D014405:Tuftsin / Q000494:pharmacology*
D010406:Penicillins; D014405:Tuftsin
Prolongirovannoe deĭstvie taftsina v usloviiakh penitsillinovoĭ épilepsii.