title: Simultaneous determination of tenidap and its stable isotope analog in serum by high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry.
abstract: A specific high-performance liquid chromatographic/atmospheric pressure chemical ionization tandem mass spectrometric assay for the quantitative determination of tenidap and its D3 analog in human serum is described. The assay exhibited a linear dynamic range of 0.1-25 micrograms ml-1. Its precision for the two analytes over the range was 17% or better. The assay validity and its utility to investigate changes in tenidap bioequivalence and pharmacokinetics are presented.
authors.affiliation: Central Research Division, Pfizer Inc., Groton, Connecticut 06340.
authors.forename: M J
authors.initials: MJ
authors.lastname: Avery
authors.forename: D Y
authors.initials: DY
authors.lastname: Mitchell
authors.forename: F C
authors.initials: FC
authors.lastname: Falkner
authors.forename: H G
authors.initials: HG
authors.lastname: Fouda
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000097:blood*; D006801:Humans; D007211:Indoles / Q000097:blood*; D013058:Mass Spectrometry / Q000379:methods*; D000078183:Oxindoles
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007211:Indoles; D000078183:Oxindoles; C062866:tenidap