Platelet aggregation inhibitors from Populus sieboldii Miquel.
The water extract of Populus sieboldii Miquel (Salicaceae) inhibited arachidonic acid-induced platelet aggregation. Pyrocatechol and salicyl alcohol were isolated as active constituents. Pyrocatechol showed an inhibitory effect on platelet aggregation induced by arachidonic acid with IC100 value of 4 microM, which was 25 times more potent than aspirin.
Kagawa
K
K
Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
Tokura
K
K
Uchida
K
K
Kakushi
H
H
Shike
T
T
D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*
D004365:Drugs, Chinese Herbal; D010975:Platelet Aggregation Inhibitors