title: Discovery of a novel class of orally active, non-peptide angiotensin II antagonists.
authors.affiliation: Abbott Laboratories, Pharmaceutical Products Division, Abbott Park, Illinois 60064.
authors.forename: B
authors.initials: B
authors.lastname: De
authors.forename: M
authors.initials: M
authors.lastname: Winn
authors.forename: T M
authors.initials: TM
authors.lastname: Zydowsky
authors.forename: D J
authors.initials: DJ
authors.lastname: Kerkman
authors.forename: J F
authors.initials: JF
authors.lastname: DeBernardis
authors.forename: J
authors.initials: J
authors.lastname: Lee
authors.forename: S
authors.initials: S
authors.lastname: Buckner
authors.forename: R
authors.initials: R
authors.lastname: Warner
authors.forename: M
authors.initials: M
authors.lastname: Brune
authors.forename: A
authors.initials: A
authors.lastname: Hancock
mesh_terms: D000284:Administration, Oral; D000804:Angiotensin II / Q000037:antagonists & inhibitors*; D000818:Animals; D001713:Biphenyl Compounds / Q000008:administration & dosage / Q000138:chemical synthesis / Q000493:pharmacokinetics; D007093:Imidazoles / Q000008:administration & dosage / Q000138:chemical synthesis / Q000493:pharmacokinetics; D019808:Losartan; D011743:Pyrimidines / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D051381:Rats; D011918:Rats, Inbred SHR; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship; D013777:Tetrazoles / Q000008:administration & dosage / Q000138:chemical synthesis / Q000493:pharmacokinetics
chemical_list: D001713:Biphenyl Compounds; D007093:Imidazoles; D011743:Pyrimidines; D013777:Tetrazoles; D000804:Angiotensin II; D019808:Losartan