title: Biological and clinical implication of cellular DNA content in renal cell carcinomas.
abstract: DNA flow cytometric analysis (FCM) was performed on surgical bioptic samples taken from 82 renal cell carcinomas. FCM has evidenced that 35% (29/82) of renal carcinomas resulted diploid, 65% (53/82) aneuploid and of the latter 22% (12/53) multiclonal. Our results do not indicate any relationship among cytometric ploidy, Fuhrman grading, Robson and pTNM staging. A possible interesting increase of aneuploidy frequency was observed between the NMV (66%) subgroup and the no zero NMV (90%) subgroup, while in diploid patients these values were 40% and 10%, respectively. Follow-up data evidence a significant difference in survival pattern of patients between diploid and aneuploid groups. In conclusion, our results show that cytometric ploidy is a potential important prognostic parameter in survival term.
authors.affiliation: Department of Urology, University of Rome La Sapienza, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Di Silverio
authors.forename: M
authors.initials: M
authors.lastname: Gallucci
authors.forename: G P
authors.initials: GP
authors.lastname: Flammia
authors.forename: A
authors.initials: A
authors.lastname: De Vico
authors.forename: M
authors.initials: M
authors.lastname: Caponera
authors.forename: P
authors.initials: P
authors.lastname: Eleuteri
authors.forename: D
authors.initials: D
authors.lastname: Forte
authors.forename: D
authors.initials: D
authors.lastname: Cavallo
authors.forename: R
authors.initials: R
authors.lastname: De Vita
mesh_terms: D002292:Carcinoma, Renal Cell / Q000737:chemistry / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D004273:DNA, Neoplasm / Q000032:analysis*; D005434:Flow Cytometry; D005500:Follow-Up Studies; D006801:Humans; D007680:Kidney Neoplasms / Q000737:chemistry / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D008875:Middle Aged; D009367:Neoplasm Staging; D011003:Ploidies; D011379:Prognosis; D015996:Survival Rate
chemical_list: D004273:DNA, Neoplasm