title: Treatment of advanced localised prostatic cancer by orchiectomy, radiotherapy, or combined treatment. A Medical Research Council Study. Urological Cancer Working Party--Subgroup on Prostatic Cancer.
abstract: A total of 277 patients with apparently localised prostatic cancer (T2-T4 NXMO) were allocated at random to receive radiotherapy alone (88), orchiectomy alone (90) and combined therapy (99) between 1980 and 1985. The main outcome measures were survival, time to appearance of metastases and treatment of local disease progression by further transurethral resection. Orchiectomy, whether alone or with radiotherapy, produced a significant delay in detection of metastases when compared with radiotherapy alone. There were no statistically significant differences between the 3 treatment groups in local disease control or in overall survival.
authors.affiliation: Department of Urology, Churchill Hospital, Headington, Oxford.
authors.forename: G J
authors.initials: GJ
authors.lastname: Fellows
authors.forename: P B
authors.initials: PB
authors.lastname: Clark
authors.forename: L L
authors.initials: LL
authors.lastname: Beynon
authors.forename: J
authors.initials: J
authors.lastname: Boreham
authors.forename: C
authors.initials: C
authors.lastname: Keen
authors.forename: M C
authors.initials: MC
authors.lastname: Parkinson
authors.forename: R
authors.initials: R
authors.lastname: Peto
authors.forename: J N
authors.initials: JN
authors.lastname: Webb
mesh_terms: D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D009919:Orchiectomy / Q000009:adverse effects / Q000401:mortality; D011467:Prostate / Q000601:surgery; D011471:Prostatic Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery*; D011878:Radiotherapy / Q000009:adverse effects; D012307:Risk Factors