title: 99Tcm-HMPAO-labelled white blood cell scanning for the detection of carditis in the differentiation of rheumatic fever and inactive rheumatic heart disease in children.
abstract: Myocardial imaging with 99Tcm-hexamethylpropylene amineoxime (HMPAO)-labelled white blood cells (Tc-WBC) was used to detect carditis and differentiate rheumatic fever (RF) and inactive rheumatic heart disease (IRHD). Ten cases of RF and 15 cases of IRHD were studied, and the results revealed 60% (6/10) of the cases of RF with carditis, but none of the cases (0/15) of IRHD with carditis. There was significant difference (P less than 0.05, by Fisher's test) between RF and IRHD. In our preliminary conclusion, Tc-WBC heart scanning may be a noninvasive method for evaluating the existence of carditis in cases of RHD and in the differentiation of RF and IRHD.
authors.affiliation: Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan, Republic of China.
authors.forename: C H
authors.initials: CH
authors.lastname: Kao
authors.forename: K S
authors.initials: KS
authors.lastname: Hsieh
authors.forename: Y L
authors.initials: YL
authors.lastname: Wang
authors.forename: C W
authors.initials: CW
authors.lastname: Chen
authors.forename: S J
authors.initials: SJ
authors.lastname: Wang
authors.forename: S H
authors.initials: SH
authors.lastname: Yeh
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006331:Heart Diseases / Q000000981:diagnostic imaging*; D006801:Humans; D007249:Inflammation / Q000000981:diagnostic imaging; D007962:Leukocytes; D008297:Male; D015609:Organotechnetium Compounds; D010091:Oximes; D011877:Radionuclide Imaging; D012213:Rheumatic Fever / Q000000981:diagnostic imaging*; D012214:Rheumatic Heart Disease / Q000000981:diagnostic imaging*; D019690:Technetium Tc 99m Exametazime
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime