[Increase of seizure threshold and resistance to stress in rats after immunization against fragment of diazepam-binding inhibitor].
White rats were immunized against fragment of diazepam-binding inhibitor octadecaneuropeptide (ODN) with conjugate ODN bovine serum albumin. This rats have reduced reactions of fear and anxiety in stress model of "open field" and in conflict Vogel test; their pain sensitivity ("tail flick" test) was lowered. The number and intensity of generalized seizure reactions after injection of pentylenetetrazole were decreased. The results show that active immunization to endogenous ODN has stress--protective and anti-seizure effects.
Ashmarin
I P
IP
Vakulina
O P
OP
Rozhanets
V V
VV
Maksimov
V V
VV
Samukov
V V
VV
Kalashnikov
V V
VV
Mizenko
G A
GA
D000818:Animals; D026261:Diazepam Binding Inhibitor; D007114:Immunization; D009479:Neuropeptides / Q000276:immunology*; D010147:Pain Measurement; D010433:Pentylenetetrazole; D010446:Peptide Fragments; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*; D013315:Stress, Psychological / Q000517:prevention & control*
D026261:Diazepam Binding Inhibitor; D009479:Neuropeptides; D010446:Peptide Fragments; C067529:diazepam binding inhibitor (33-50); D010433:Pentylenetetrazole
Povyshenie sudorozhnogo poroga i ustoĭchivosti krys k stressu posle immunizatsii k fragmentu diazepam-sviazyvaiushchego ingibitora.