Influence of physico-chemical parameters on the release kinetics of ketoprofen from Poly(HEMA) crosslinked microspheres.
This report analyses the release of Ketoprofen from Poly(HEMA) microspheres crosslinked with EGDMA at different crosslinking ratios and loaded by soaking in saturated solutions of the drug. Release appears to be influenced by the dissolution of Ketoprofen in the hydrogel and it is strictly correlated with the diffusibility of the drug in the gelled matrix. The release rate of the drug in the hydrogel rises with the increase in the diffusional conductance and the release kinetics approaches zero order particularly at the higher values of the diffusional conductance.
Orienti
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Dipartimento di Scienze Farmaceutiche, Bologna, Italy.
Bertasi
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Zecchi
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D003432:Cross-Linking Reagents; D004058:Diffusion; D007660:Ketoprofen / Q000493:pharmacokinetics*; D007700:Kinetics; D008689:Methacrylates / Q000378:metabolism; D008863:Microspheres; D011102:Polyhydroxyethyl Methacrylate / Q000378:metabolism*
D003432:Cross-Linking Reagents; D008689:Methacrylates; D011102:Polyhydroxyethyl Methacrylate; C004919:ethylene dimethacrylate; D007660:Ketoprofen