The developmental relationship between NK cells and T cells.
NK cells and T cells share many features, suggesting that they have a common origin. Here, Lewis Lanier and colleagues describe recent studies of fetal ontogeny and thymic development that provide support for this hypothesis, and propose an integrated scheme for NK-cell and T-cell development.
Lanier
L L
LL
DNAX Research Institute for Cellular and Molecular Biology, Palo Alto, CA 94304.
Spits
H
H
Phillips
J H
JH
D000818:Animals; D017252:CD3 Complex / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000196:embryology / Q000276:immunology
D017252:CD3 Complex; D011948:Receptors, Antigen, T-Cell