title: Quinolones as an alternative treatment of chlamydial, mycoplasma and gonococcal urogenital infections.
abstract: We report the results of several trials aimed at evaluating the quinolones in urogenital infections. In Chlamydia trachomatis infections, ofloxacin (200 mg b.i.d. for 10 days) gave a cure rate of 98% (n = 66), and fleroxacin (400 mg s.i.d. for 7 days) provided a cure rate of 89% (n = 19). A double-blind study comparing fleroxacin (600 mg s.i.d.) to doxycycline (100 mg b.i.d.) for 7 days showed similar high cure rates for both regimens (100%; n = 23). In Mycoplasma hominis infections, ofloxacin (200 mg b.i.d. for 10 days) yielded a cure rate of 86% (n = 50) for M. hominis and 55% (n = 43) for Ureaplasma urealyticum. Gonococcal infections (n = 122) were all cured by a single dose of 200 mg ofloxacin. Both ofloxacin and fleroxacin were well tolerated and may be recommended for patients with chlamydial or uncomplicated gonococcal infections, although 600 mg fleroxacin showed a higher incidence of adverse events compared to doxycycline.
authors.affiliation: Ludwig Boltzmann Institute for Research on Infectious Venerodermatological Diseases, Vienna, Austria.
authors.forename: C
authors.initials: C
authors.lastname: Ziegler
authors.forename: A
authors.initials: A
authors.lastname: Stary
authors.forename: H
authors.initials: H
authors.lastname: Mailer
authors.forename: W
authors.initials: W
authors.lastname: Kopp
authors.forename: W
authors.initials: W
authors.lastname: Gebhart
authors.forename: J
authors.initials: J
authors.lastname: Söltz-Szöts
mesh_terms: D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002690:Chlamydia Infections / Q000188:drug therapy*; D002692:Chlamydia trachomatis; D004311:Double-Blind Method; D005260:Female; D052776:Female Urogenital Diseases / Q000188:drug therapy* / Q000382:microbiology; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008297:Male; D052801:Male Urogenital Diseases; D009174:Mycoplasma; D009175:Mycoplasma Infections / Q000188:drug therapy*; D009344:Neisseria gonorrhoeae; D016869:Ureaplasma Infections / Q000188:drug therapy
chemical_list: D042462:4-Quinolones; D000890:Anti-Infective Agents