title: Association of methotrexate, rheumatoid arthritis and lymphoma: report of 2 cases and literature review.
abstract: We describe 2 Caucasian men with rheumatoid arthritis (RA) who developed non-Hodgkin's lymphoma of identical histological type during treatment with low dose oral weekly methotrexate (MTX). Both patients had longstanding RA and had been treated with MTX for over 2 years at time of tumor diagnosis; neither had secondary Sjögren's syndrome. The oncogenic potential of MTX and RA arthritis is reviewed.
authors.affiliation: Department of Medicine, Duke University Medical Center, Durham, NC 27710.
authors.forename: S F
authors.initials: SF
authors.lastname: Kingsmore
authors.forename: B D
authors.initials: BD
authors.lastname: Hall
authors.forename: N B
authors.initials: NB
authors.lastname: Allen
authors.forename: J R
authors.initials: JR
authors.lastname: Rice
authors.forename: D S
authors.initials: DS
authors.lastname: Caldwell
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000139:chemically induced; D016403:Lymphoma, Large B-Cell, Diffuse / Q000139:chemically induced; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D008875:Middle Aged; D010641:Phenotype
chemical_list: D008727:Methotrexate