title: Long-term supplementation with n-3 fatty acids, I: Effect on blood lipids, haemostasis and blood pressure.
abstract: The effect of dietary supplementation with 4 g of n-3 polyunsaturated fatty acids (PUFA) daily for 9 months on blood pressure, plasma lipids and lipoproteins, platelet function, coagulation and fibrinolysis was studied in 24 healthy volunteers. Each variable was determined before, after 6 weeks and 9 months of supplementation with n-3 PUFA, and 3 months after the supplementation period had ended. Systolic and diastolic blood pressure declined after intake of n-3 PUFAs. Plasma triglycerides were reduced, and there was a trend towards an increase in HDL-cholesterol after 9 months of supplementation, while total cholesterol, LDL-cholesterol and apolipoproteins A1 and B were unaltered. The bleeding time was increased, and plasma levels of von Willebrand factor decreased after 9 months supplementation with n-3 PUFA. Fibrinogen levels increased, while fibrinolysis was reduced after 9 months supplementation with n-3 PUFA. Overall, no clear benefit on lipid pattern and haemostasis was achieved with respect to development of coronary heart disease.
authors.affiliation: Department of Clinical Chemistry, Aalborg Hospital, Denmark.
authors.forename: E B
authors.initials: EB
authors.lastname: Schmidt
authors.forename: H H
authors.initials: HH
authors.lastname: Lervang
authors.forename: K
authors.initials: K
authors.lastname: Varming
authors.forename: P
authors.initials: P
authors.lastname: Madsen
authors.forename: J
authors.initials: J
authors.lastname: Dyerberg
mesh_terms: D000328:Adult; D001777:Blood Coagulation / Q000502:physiology; D001792:Blood Platelets / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology*; D004041:Dietary Fats / Q000008:administration & dosage*; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D005260:Female; D005342:Fibrinolysis / Q000502:physiology; D005395:Fish Oils / Q000008:administration & dosage; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D010979:Platelet Function Tests; D013997:Time Factors
chemical_list: D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D005395:Fish Oils; D008055:Lipids; D008074:Lipoproteins