title: Comparison between new saliva stimulants in patients with dry mouth: a placebo-controlled double-blind crossover study.
abstract: Two new saliva stimulants: V6 and a mucin containing chewing gum were tested in this placebo-controlled double-blind crossover study. Forty-three patients (mean age 63 yr) complaining of dry mouth participated. The products were administered in a randomized order, and used for 2 wk each. The effect was evaluated by interviews and by determining changes in stimulated and unstimulated saliva flow rates. A positive effect was reported by 64%, 44%, and 26% of the patients using the mucin chewing gum, V6, and the placebo, respectively. More than 2/3 of the patients found the mucin chewing gum efficient at various times and situations. Sixty-one percent of the patients preferred the mucin chewing gum, 21% V6, and 5% the placebo product. Fifty percent of the patients had an increase in unstimulated salivary secretion rate from all products after 14 days regular use indicating a long-term effect.
authors.affiliation: Division of Auxilliary Training and Education, Royal Dental College, Copenhagen, Denmark.
authors.forename: A
authors.initials: A
authors.lastname: Aagaard
authors.forename: S
authors.initials: S
authors.lastname: Godiksen
authors.forename: P T
authors.initials: PT
authors.lastname: Teglers
authors.forename: M
authors.initials: M
authors.lastname: Schiødt
authors.forename: U
authors.initials: U
authors.lastname: Glenert
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002638:Chewing Gum; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009077:Mucins / Q000627:therapeutic use*; D010349:Patient Compliance; D017060:Patient Satisfaction; D010919:Placebos; D012463:Saliva / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D012471:Salivary Proteins and Peptides / Q000032:analysis; D012636:Secretory Rate; D013649:Taste; D014508:Urea / Q000627:therapeutic use*; D014987:Xerostomia / Q000209:etiology / Q000628:therapy*
chemical_list: D002638:Chewing Gum; D009077:Mucins; D010919:Placebos; D012471:Salivary Proteins and Peptides; D014508:Urea