title: Intractable epilepsy in adults.
abstract: Intractable epilepsy can be defined as seizures which have not been completely controlled with AEDs 1 year after onset despite accurate diagnosis and carefully monitored treatment. Once intractable, there is a low probability of remission. Predictors of intractability include the presence of partial seizures, structural abnormalities on imaging studies, and abnormalities on the neurological examinations. If a person continues to have seizures in spite of adequate treatment with AEDs, surgical options should be considered.
authors.affiliation: Department of Neurology and Pharmacy, University of Minnesota, Minneapolis.
authors.forename: I E
authors.initials: IE
authors.lastname: Leppik
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D004569:Electroencephalography / Q000187:drug effects*; D004828:Epilepsies, Partial / Q000188:drug therapy / Q000503:physiopathology; D004827:Epilepsy / Q000188:drug therapy* / Q000503:physiopathology; D004829:Epilepsy, Generalized / Q000188:drug therapy / Q000503:physiopathology; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D006801:Humans
chemical_list: D000927:Anticonvulsants