title: [Alkaline and acid phosphatase activity in the dynamics of ectopic osteogenesis].
abstract: Activities of marker enzymes of osteoblasts (alkaline phosphatase), osteoclasts (tartrate-resistant isoform of acid phosphatase), and macrophages (tartrate-sensitive isoform of acid phosphatase) in bone tissue forming after osteoinduction on the basis of demineralized bone matrix were under study. Early (1 week) stages of osteosynthesis were characterized by low activity of alkaline phosphatase, acid phosphatase being represented by the tartrate-sensitive isoform. Two-three weeks later alkaline phosphatase activity grew and the tartrate-resistant isoform of acid phosphatase appeared. By the fourth-sixth weeks of osteogenesis alkaline phosphatase activity stabilized at a certain level and acid phosphatase activity still grew at the expense of the tartrate-resistant isoform. Conformity of the enzymologic data to changes in cellular populations in ectopic osteogenesis is discussed.
authors.forename: D V
authors.initials: DV
authors.lastname: Gutkin
authors.forename: E A
authors.initials: EA
authors.lastname: Vasil'eva
authors.forename: D D
authors.initials: DD
authors.lastname: Sumarokov
authors.forename: V M
authors.initials: VM
authors.lastname: Kudymov
authors.forename: V M
authors.initials: VM
authors.lastname: Ognivenko
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism*; D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D016025:Bone Transplantation / Q000379:methods; D007527:Isoenzymes / Q000378:metabolism; D008264:Macrophages / Q000201:enzymology; D008297:Male; D010006:Osteoblasts / Q000201:enzymology; D010010:Osteoclasts / Q000201:enzymology; D010012:Osteogenesis / Q000502:physiology*; D051381:Rats; D013997:Time Factors; D016042:Transplantation, Heterotopic
chemical_list: D007527:Isoenzymes; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase
vernacular_title: Aktivnost' shchelochnoĭ i kisloĭ fosfataz v dinamike éktopicheskogo osteogeneza.