Stereoselective synthesis and antimalarial activity of alpha-artelinic acid from artemisinin.
alpha-Artelinic acid [8], a potent, stable, and water-soluble antimalarial agent, has been synthesized from artemisinin [1], the sesquiterpene lactone endoperoxide isolated from Artemisia annua. The blood schizontocidal antimalarial activity of alpha-artelinic acid evaluated against Plasmodium knowlesi is also reported.
Vishwakarma
R A
RA
Central Institute of Medicinal and Aromatic Plants, Lucknow, India.
Mehrotra
R
R
Tripathi
R
R
Dutta
G P
GP
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology; D037621:Artemisinins; D008253:Macaca mulatta; D008288:Malaria / Q000188:drug therapy / Q000469:parasitology; D016790:Plasmodium knowlesi; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology
D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; C062768:artelinic acid; C031327:artemisinin