Subchronic toxicity study of peppermint oil in rats.
Peppermint oil was given p.o. to four groups of 28 rats at dosage levels of 0, 10, 40, and 100 mg/kg body wt. per day for 90 days. At the highest dose histopathological changes consisting of cyst-like spaces scattered in the white matter of cerebellum were seen. No other signs of encephalopathy were observed. Nephropathy was seen in the male rats in the highest dose group. A no-observed-adverse-effect level of 40 mg/kg body wt. per day was determined.
Spindler
P
P
Institute of Toxicology, National Food Agency, Soeborg, Denmark.
Madsen
C
C
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002531:Cerebellum / Q000187:drug effects / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008297:Male; D036142:Mentha piperita; D010938:Plant Oils / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
D010938:Plant Oils; C015424:peppermint oil