title: Amikacin once daily plus metronidazole versus amikacin twice daily plus metronidazole in colorectal surgery.
abstract: Amikacin administered once a day plus metronidazole is compared with amikacin given twice a day plus metronidazole in colorectal surgery (prophylactic or therapeutic antibiotic treatment). A total of 325 patients were studied in this randomized multicenter trial. The results of this trial suggest that a single daily dose of amikacin is equally as effective in combating infectious postoperative complications as twice a day administration. The side effects were similar, with the exception of renal effects, which were somewhat more pronounced in once a day amikacin administration. Nevertheless, all the renal function alterations were transient and we observed no definitive renal insufficiency.
authors.affiliation: Department of Surgery, Hôpital Français, Brussels, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Mendes da Costa
authors.forename: L
authors.initials: L
authors.lastname: Kaufman
mesh_terms: D000328:Adult; D000368:Aged; D000583:Amikacin / Q000008:administration & dosage* / Q000009:adverse effects; D001424:Bacterial Infections / Q000517:prevention & control*; D003106:Colon / Q000601:surgery*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D012007:Rectum / Q000601:surgery*
chemical_list: D008795:Metronidazole; D000583:Amikacin