Effect of insulin therapy on blood pressure in NIDDM patients with secondary failure.
OBJECTIVE
To assess the effect of insulin therapy on blood pressure in NIDDM patients with secondary failure.


METHODS
The influence of insulin treatment on blood pressure was assessed retrospectively in a group of 80 NIDDM patients with secondary failure to diet and maximum doses of oral hypoglycemic agents. Weight, blood glucose, and blood pressure were recorded over a 3-mo period before and after the initiation of insulin therapy.


RESULTS
There was a significant rise in systolic (131.8 +/- 1.7 to 148 +/- 1.9 mmHg, P less than 0.05) and diastolic (80.9 +/- 0.9 to 89.2 +/- 1.0 mmHg, P less than 0.02) blood pressures with insulin treatment. Insulin treatment was associated with a significant decrease in blood glucose (18.36 +/- 0.28 to 10.4 +/- 0.34 mM, P less than 0.01) and an increase in weight (72.1 +/- 1.6 to 78 +/- 1.7 kg, P = 0.01). A control group of 80 NIDDM patients matched for age, weight, BMI, and duration of diabetes demonstrated no significant change in blood pressure over a matched period of follow-up.


CONCLUSIONS
This study has shown that insulin therapy is associated with significant elevation of both systolic and diastolic blood pressures.
Randeree
H A
HA
Department of Medicine, University of Natal, Durban, South Africa.
Omar
M A
MA
Motala
A A
AA
Seedat
M A
MA
D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects*; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000503:physiopathology*; D003971:Diastole / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D007328:Insulin / Q000627:therapeutic use*; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013599:Systole / Q000187:drug effects; D015430:Weight Gain / Q000187:drug effects
D001786:Blood Glucose; D007328:Insulin