Hemocompatibility of titanium nitride.
The left ventricular assist device is based on the principle of the Maillard-Wenkel rotative pump. The materials which make up the pump must present particular mechanical, tribological, thermal and chemical properties. Titanium nitride (TiN) because of its surface properties and graphite because of its bulk characteristics have been chosen. The present study evaluated the in vitro hemocompatibility of TiN coating deposited by the chemical vapor deposition process. Protein adsorption, platelet retention and hemolysis tests have been carried out. In spite of some disparities, the TiN behavior towards albumin and fibrinogen is interesting, compared with the one of a reference medical grade elastomer. The platelet retention test gives similar results as those achieved with the same elastomer. The hemolysis percentage is near to zero. TiN shows interesting characteristics, as far as mechanical and tribological problems are concerned, and presents very encouraging blood tolerability properties.
Dion
I
I
Laboratoire de Biophysique, Université de Bordeaux II, France.
Baquey
C
C
Candelon
B
B
Monties
J R
JR
D000327:Adsorption; D001672:Biocompatible Materials; D001792:Blood Platelets / Q000502:physiology*; D001798:Blood Proteins / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism; D006353:Heart-Assist Devices; D006461:Hemolysis; D006801:Humans; D066298:In Vitro Techniques; D012709:Serum Albumin / Q000378:metabolism; D012826:Silicone Elastomers; D014025:Titanium
D001672:Biocompatible Materials; D001798:Blood Proteins; D012709:Serum Albumin; D012826:Silicone Elastomers; C041500:titanium nitride; D005340:Fibrinogen; D014025:Titanium