Relative efficacy of melarsen oxide compared with mel Cy (Cymelarsan) when used in combination with difluoromethylornithine in the treatment of trypanosomiasis of the central nervous system.
A comparison was made between the efficacy of mel Cy (Cymelarsan) and melarsen oxide to cure central nervous system trypanosomiasis in a chronic Trypanosoma brucei mouse model. Combination treatment with difluoromethylornithine and arsenical was used and it was found that there was only a marginal advantage in using the water-soluble mel Cy in terms of the numbers of mice cured.
Jennings
F W
FW
Department of Veterinary Parasitology, University of Glasgow, UK.
D000818:Animals; D001152:Arsenicals / Q000627:therapeutic use*; D002493:Central Nervous System Diseases / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D000518:Eflornithine / Q000627:therapeutic use*; D051379:Mice; D008954:Models, Biological; D014344:Trypanocidal Agents / Q000627:therapeutic use*; D014353:Trypanosomiasis, African / Q000188:drug therapy*
D001152:Arsenicals; D014344:Trypanocidal Agents; C008345:melarsen; C062789:melaminylthioarsenate; D000518:Eflornithine