title: Prognostic value of captopril renal scintigraphy in renovascular hypertension.
abstract: This study evaluates the prognostic value of captopril renal scintigraphy in hypertensive patients undergoing renal artery revascularization. Preoperative studies of 51 patients were correlated with blood pressure results at 6- and 12-mo follow-up. Captopril-renal scintigraphy was carried out 1 hr after oral administration of 50 mg of captopril, using either 220 MBq of 99mTc-DTPA or 74 MBq of 99mTc-MAG3, followed by a baseline study in case of abnormal results. Evidence of amelioration or normalization in relation to captopril study was considered predictive of blood pressure control following treatment. Blood pressure response was favorable in 37 patients, but failed to show any improvement in 14. The scintigraphic test was positive in 33 patients (15 cured, 17 improved, 1 failed) and negative in 18 (3 cured, 2 improved, 13 failed). Sensitivity and specificity for renovascular hypertension was 86.5% and 93%, respectively. For blood pressure cure and improvement, the test had positive and negative predictive values of 97% and 72%, respectively. A positive preoperative captopril renal scintigraphic result is a strong predictor of hypertension curability by renal artery revascularization.
authors.affiliation: Department of Nuclear Medicine, S. Orsola-Malpighi Policlinic Hospital, Bologna, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Dondi
authors.forename: S
authors.initials: S
authors.lastname: Fanti
authors.forename: A
authors.initials: A
authors.lastname: De Fabritiis
authors.forename: A
authors.initials: A
authors.lastname: Zuccala
authors.forename: R
authors.initials: R
authors.lastname: Gaggi
authors.forename: M
authors.initials: M
authors.lastname: Mirelli
authors.forename: A
authors.initials: A
authors.lastname: Stella
authors.forename: M
authors.initials: M
authors.lastname: Marengo
authors.forename: F
authors.initials: F
authors.lastname: Losinno
authors.forename: N
authors.initials: N
authors.lastname: Monetti
mesh_terms: D000328:Adult; D000368:Aged; D000800:Angioplasty, Balloon; D001794:Blood Pressure; D002216:Captopril; D005260:Female; D006801:Humans; D006978:Hypertension, Renovascular / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011866:Radioisotope Renography; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy; D012079:Renal Circulation; D012680:Sensitivity and Specificity; D017263:Technetium Tc 99m Mertiatide; D016284:Technetium Tc 99m Pentetate; D016896:Treatment Outcome
chemical_list: D017263:Technetium Tc 99m Mertiatide; D002216:Captopril; D016284:Technetium Tc 99m Pentetate