title: Skin response to tuberculin in pig foetuses and germ-free piglets.
abstract: Cellular response to intradermally administered PPD (2 TU) was demonstrated in pig foetuses of various ages and in germ-free piglets. CD2+, CD4+, CD8-, 86D-, SLA-D- T lymphocytes were the predominant cells in the skin tuberculin reaction in both foetuses and germ-free animals. Reactive T cells were observed as early as in mid-gestation, whereas SLA-D+ (porcine MHC class II) cells appeared only in older foetuses. Polymorphonuclear leukocytes were never observed in the PPD reaction.
authors.affiliation: Department of Immunology and Gnotobiology, Czechoslovak Academy of Sciences, Prague.
authors.forename: I
authors.initials: I
authors.lastname: Trebichavský
authors.forename: F
authors.initials: F
authors.lastname: Kovárů
authors.forename: Z
authors.initials: Z
authors.lastname: Reháková
authors.forename: L
authors.initials: L
authors.lastname: Mandel
authors.forename: R
authors.initials: R
authors.lastname: Pospísil
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D005333:Fetus / Q000166:cytology / Q000276:immunology*; D005856:Germ-Free Life / Q000276:immunology*; D007107:Immune System / Q000196:embryology; D012867:Skin / Q000166:cytology / Q000196:embryology / Q000276:immunology*; D013552:Swine; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology; D014373:Tuberculin / Q000276:immunology*
chemical_list: D014373:Tuberculin