title: Splenic hematoma in acute pancreatitis. Role of coagulation disorders.
abstract: Splenic hematomas are infrequent complications of acute pancreatitis. In some cases, local factors that may play a role in the pathogenesis of the hematoma (thrombosis of the splenic artery or veins, intrasplenic pseudocysts, perisplenic adhesions, enzymatic digestion) are found. In the absence of local factors, the etiology of splenic hemorrhage remains unknown. We report two cases of splenic hematoma occurring during an acute necro-hemorrhagic pancreatitis associated with renal failure that required renal replacement therapy (hemodialysis and continuous arteriovenous hemodialysis). In both cases, more than half of splenic parenchyma was affected by multiple infarctions. No local factors responsible for the splenic abnormalities were detected in either case. Thrombosis of the splenic arterial microcirculation and a coagulation disorder consistent with disseminated intravascular coagulation was detected in one patient. In the second patient, coagulation disorders secondary to either liver disease, pancreatitis and its septic complications, or extracorporeal circuit heparinization for renal replacement therapy were present. Coagulation disorders should be considered whenever a splenic hematoma is found in a patient with acute pancreatitis. Disseminated intravascular coagulation may be the etiology of a splenic hematoma in acute pancreatitis.
authors.affiliation: Department of Surgery, Hospital de la Santa Creu i Sant Pau, Universitat Autónoma de Barcelona, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Clavé
authors.forename: S
authors.initials: S
authors.lastname: Guillaumes
authors.forename: I
authors.initials: I
authors.lastname: Blanco
authors.forename: J
authors.initials: J
authors.lastname: Martínez de Hurtado
authors.forename: J
authors.initials: J
authors.lastname: Esquius
authors.forename: L
authors.initials: L
authors.lastname: Marruecos
authors.forename: J
authors.initials: J
authors.lastname: Fontcuberta
authors.forename: C
authors.initials: C
authors.lastname: Pérez
authors.forename: A
authors.initials: A
authors.lastname: Farré
authors.forename: F
authors.initials: F
authors.lastname: Lluís
mesh_terms: D000208:Acute Disease; D001780:Blood Coagulation Tests; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000473:pathology; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006452:Hemoglobinometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000097:blood* / Q000473:pathology / Q000601:surgery; D010314:Partial Thromboplastin Time; D010976:Platelet Count; D011183:Postoperative Complications / Q000097:blood* / Q000473:pathology / Q000601:surgery; D011516:Prothrombin / Q000378:metabolism; D012086:Reoperation; D013154:Spleen / Q000473:pathology; D013158:Splenic Diseases / Q000097:blood* / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D011516:Prothrombin; D005340:Fibrinogen