Aspirin-induced asthma: pathogenesis and clinical presentation.
In about 10% of adult asthmatics, aspirin precipitates open asthmatic attacks. Pathogenesis, clinical features, and diagnosis of a distinct clinical syndrome known as aspirin-induced asthma are described. The syndrome attracts the attention of scientists and clinicians who are convinced that unraveling its mysteries may give new insights into the pathogenesis of asthma.
Szczeklik
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Department of Medicine, Copernicus Academy of Medicine, Krakow, Poland.
D016718:Arachidonic Acid / Q000378:metabolism; D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D015289:Leukotrienes / Q000378:metabolism; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism
D015289:Leukotrienes; D016718:Arachidonic Acid; D011451:Prostaglandin-Endoperoxide Synthases; D001241:Aspirin