title: An immunodominant haptenic epitope of carbamazepine detected in serum from patients given long-term treatment with carbamazepine without allergic reaction.
abstract: An anticarbamazepine antibody was detected in the serum of a patient with severe carbamazepine-induced serum sickness. We found that the patient's T cells and IgG antibody recognized an epitope which appeared in subjects showing an allergic reaction, as well as that in subjects who showed no allergic reaction, after long-term carbamazepine therapy. These results show that an anti-carbamazepine immune response does not occur in the majority of subjects who undergo long-term carbamazepine therapy without developing allergic symptoms, although the immunodominant haptenic epitope of carbamazepine is present in their sera.
authors.affiliation: Department of Pediatrics, Kitasato University, School of Medicine, Kanagawa, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Igarashi
authors.forename: N
authors.initials: N
authors.lastname: Hosoda
authors.forename: Y
authors.initials: Y
authors.lastname: Bando
authors.forename: K
authors.initials: K
authors.lastname: Shimanuki
authors.forename: W
authors.initials: W
authors.lastname: Sunaoshi
authors.forename: H
authors.initials: H
authors.lastname: Shirai
authors.forename: H
authors.initials: H
authors.lastname: Miura
mesh_terms: D002220:Carbamazepine / Q000009:adverse effects / Q000276:immunology*; D002648:Child; D004334:Drug Administration Schedule; D004342:Drug Hypersensitivity / Q000276:immunology*; D005260:Female; D006241:Haptens / Q000276:immunology*; D006801:Humans; D016056:Immunodominant Epitopes / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D012713:Serum Sickness / Q000209:etiology / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D006241:Haptens; D016056:Immunodominant Epitopes; D007074:Immunoglobulin G; D002220:Carbamazepine