[The antiproliferative activity of monoclonal anti-idiotypic antibodies imitating the biological effects of human alpha-interferons].
The experimental data from the study of antiproliferative activity (AP-activity) of monoclonal antiidiotypic antibody (mono-Ai-At) imitating biological effects of human alpha interferons (h-IF-alpha) are presented. The mono-Ai-At present in the ascitic and culture fluids (the culture fluid was obtained from cultivation of hybrid cells immobilized in alginate-gelatine gel) were shown to inhibit propagation of IF-sensitive continuous cells from normal and tumor tissues. The AP-activity of mono-Ai-At was found to be within the range of their antiviral activity. It is concluded that mono-Ai-At may be used as a new experimental model for investigation of h-IF-alpha biological effects.
Barkova
E P
EP
Nagieva
F G
FG
Andzhaparidze
O G
OG
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000302:isolation & purification; D000911:Antibodies, Monoclonal / Q000302:isolation & purification; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects; D003864:Depression, Chemical; D006801:Humans; D006822:Hybrid Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D016898:Interferon-alpha / Q000494:pharmacology*; D013997:Time Factors
D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D016898:Interferon-alpha; D004247:DNA
Antiproliferativnaia aktivnost' monoklonal'nykh antiidiotipicheskikh antitel, imitiruiushchikh biologicheskie éffekty chelovecheskikh interferonov al'fa.