Reconstituting animals from immortal precursors.
Several recent experiments have shown that immortal neural and muscle cells retain the specific temporal and spatial properties of their precursor cells in the animal. In addition, the immortal cells retain the ability to differentiate in vitro and, after transplantation, in vivo. The results of these experiments suggest that the use of precursor cell lines may lead to powerful approaches for understanding the mechanisms that generate the ordered distribution of cell types in mammals.
McKay
R
R
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139.
D000818:Animals; D002478:Cells, Cultured / Q000502:physiology*; D005823:Genetics; D006801:Humans; D009132:Muscles / Q000502:physiology*; D009474:Neurons / Q000502:physiology*