[Development of interfollicular epidermis on the surface of collagen framework of the dermis in experimental animals].
The fate of interfollicular epidermis keratinocytes which filled the hair follicles bursas of collagen dermis framework was investigated in the autotransplantation experiment. Collagen dermis framework was prepared from the skin flap. Interfollicular epidermis was detached with the help of suction method and transferred to the collagen dermis framework surface which was placed previously on the full thickness skin defect surface. It was established that in this environment keratinocytes not only developed, but some of them migrated into the hair follicle bursas cavities. It resulted in the follicular-like structures formation, cell elements of which differentiated in the manner characteristic of interfollicular epidermis. However, in spite of the fact that the epidermal cells partially retained their proliferating ability, ingrowing would completely disappear by the 15th to 20th day after the transplantation.
Ostrovskiĭ
A A
AA
Shatrova
V O
VO
D000818:Animals; D003094:Collagen; D000078404:Epidermal Cells; D004817:Epidermis; D006197:Hair; D015603:Keratinocytes; D008297:Male; D051381:Rats; D016038:Skin Transplantation; D013524:Surgical Flaps
D003094:Collagen
Razvitie mezhfollikuliarnogo épidermisa na poverkhnosti kollagenovogo karkasa dermy v éksperimente.