title: Conduction properties of spinal cord axons in the myelin-deficient rat mutant.
abstract: Spinal cords of myelin-deficient and normal age-matched (control) rats were removed and their conduction and pharmacological properties studied in an in vitro brain slice chamber. The conduction velocity of the myelin-deficient dorsal column axons was reduced to about 25% of control axons; however, the amyelinated myelin-deficient axons displayed refractory periods and the ability to sustain high-frequency action potential discharge similar to that of dorsal column axons in control rats. Pharmacological results suggest that the myelin-deficient dorsal column axons qualitatively express a normal complement of ion channels and receptors. The demonstration of a normal representation of channels and receptors on these axons supports the proposal that the oligodendrocyte, and not the axon, is the site of the primary defect in the myelin-deficient rat mutant. It is concluded that, unlike acutely demyelinated axons which display marked frequency-dependent conduction block, amyelinated axons of the myelin-deficient rat spinal cord develop compensatory mechanisms to stabilize action potential conduction.
authors.affiliation: Department of Neurology, Yale University School of Medicine, New Haven, CT 06510.
authors.forename: D
authors.initials: D
authors.lastname: Utzschneider
authors.forename: J A
authors.initials: JA
authors.lastname: Black
authors.forename: J D
authors.initials: JD
authors.lastname: Kocsis
mesh_terms: D015761:4-Aminopyridine / Q000494:pharmacology; D000818:Animals; D001369:Axons / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D008297:Male; D008564:Membrane Potentials; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000502:physiology*; D009431:Neural Conduction; D051381:Rats; D011922:Rats, Mutant Strains; D012016:Reference Values; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D013779:Tetrodotoxin / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
chemical_list: D013779:Tetrodotoxin; D005680:gamma-Aminobutyric Acid; D015761:4-Aminopyridine