title: Soy of dietary source plays a preventive role against the pathogenesis of prostatitis in rats.
abstract: This study examined the effects of diet on the development of prostatitis in male rats. Adult male rats were placed on either of two specially formulated diets which differed from one another by the presence or absence of soy as the protein source. A third group of rats (control) was fed standard laboratory rat chow which also includes soy as a source of protein. After 11 weeks, it was found that rats maintained on soy-free diet developed prostatitis mainly in the lateral lobe of the prostate. Increased severity and incidence of prostatitis in rats maintained on the soy-free diet coincided with a significant decrease in urinary excretion of various phytoestrogens. There was no evidence of prostatitis in rats maintained on soy-containing diets. Urinary excretion of phytoestrogens in rats maintained on soy-containing diet was also not different from controls. These results suggest that soy as a dietary source plays a protective role against the development of prostatitis in rats, and indicate that the ventral, lateral and dorsal lobes of the rat prostate have different sensitivities to alterations in dietary factors.
authors.affiliation: Department of Population Dynamics, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205.
authors.forename: O P
authors.initials: OP
authors.lastname: Sharma
authors.forename: H
authors.initials: H
authors.lastname: Adlercreutz
authors.forename: J D
authors.initials: JD
authors.lastname: Strandberg
authors.forename: B R
authors.initials: BR
authors.lastname: Zirkin
authors.forename: D S
authors.initials: DS
authors.lastname: Coffey
authors.forename: L L
authors.initials: LL
authors.lastname: Ewing
mesh_terms: D000818:Animals; D004044:Dietary Proteins / Q000627:therapeutic use*; D004967:Estrogens / Q000652:urine; D004968:Estrogens, Non-Steroidal; D007529:Isoflavones; D008297:Male; D048789:Phytoestrogens; D010840:Phytosterols / Q000627:therapeutic use; D028321:Plant Preparations; D010940:Plant Proteins / Q000627:therapeutic use*; D011467:Prostate / Q000473:pathology; D011472:Prostatitis / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013025:Glycine max
chemical_list: D004044:Dietary Proteins; D004967:Estrogens; D004968:Estrogens, Non-Steroidal; D007529:Isoflavones; D048789:Phytoestrogens; D010840:Phytosterols; D028321:Plant Preparations; D010940:Plant Proteins