title: Effect of complete cardiac denervation on atrial natriuretic factor release in baboons.
abstract: We investigated the influence of cardiac innervation on atrial natriuretic factor (ANF) release in baboons. For this purpose, plasma ANF levels were measured in control conditions and in response to head-down (-45 degrees) and head-up tilt (+45 degrees) in six anesthetized baboons before and after complete cardiac denervation obtained by orthotopic autotransplantation of the heart. Cardiac denervation did not modify baseline plasma ANF levels (60.4 +/- 17 pg/ml before and 63.1 +/- 16 pg/ml after heart autotransplantation). In contrast the significant ANF responses to changes in central venous pressure (CVP) induced by postural maneuvers (-45 degrees, + 16.2 +/- 4 pg/ml; +45 degrees, -18.5 +/- 4 pg/ml) were markedly altered after cardiac denervation (-45 degrees, +5.8 +/- 2 pg/ml; +45 degrees, -7.6 +/- 1 pg/ml). The changes in CVP and systemic blood pressure evoked by the postural challenges were comparable before and after cardiac denervation. These results demonstrate that cardiac nerves play a role in the control of ANF release.
authors.affiliation: Institute of Internal Medicine, Cardiology, and Cardiac Surgery, 2nd Medical School, University of Naples, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Pepino
authors.forename: M
authors.initials: M
authors.lastname: Volpe
authors.forename: E A
authors.initials: EA
authors.lastname: Rose
authors.forename: A
authors.initials: A
authors.lastname: Panza
authors.forename: G
authors.initials: G
authors.lastname: Lembo
authors.forename: S
authors.initials: S
authors.lastname: Pignalosa
authors.forename: M L
authors.initials: ML
authors.lastname: Barr
authors.forename: E
authors.initials: E
authors.lastname: Covino
authors.forename: M
authors.initials: M
authors.lastname: Condorelli
authors.forename: C R
authors.initials: CR
authors.lastname: Smith
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000032:analysis / Q000378:metabolism*; D001794:Blood Pressure; D002496:Central Venous Pressure; D003714:Denervation; D006321:Heart / Q000294:innervation*; D006339:Heart Rate; D016027:Heart Transplantation / Q000502:physiology; D008297:Male; D010215:Papio; D011187:Posture; D014182:Transplantation, Autologous
chemical_list: D009320:Atrial Natriuretic Factor