W(h)ither default? Sorting and polarization in epithelial cells.
The discovery of basolateral sorting signals in the past year may leave the default pathway with nowhere to go. With new results suggesting that even more GTP-binding proteins and coatamers might be involved in transport and targeting, it is clear that the age of mapmaking in polarization research is nearly over.
Matlin
K S
KS
Harvard Medical School, Massachusetts General Hospital, Boston.
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D016764:Cell Polarity / Q000502:physiology*; D004847:Epithelial Cells; D004848:Epithelium / Q000502:physiology; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology*; D021382:Protein Sorting Signals / Q000502:physiology*
D008565:Membrane Proteins; D021382:Protein Sorting Signals