Cefdinir (FK482), an orally administered cephalosporin in vitro activity comparison against recent clinical isolates from five medical centers and determination of MIC quality control guidelines.
Cefdinir, a new oral cephalosporin, was compared to cefaclor, cefadroxil, cefixime, and cefuroxime against greater than 5000 recent aerobic clinical isolates. This multicenter study revealed broad-spectrum cefdinir activity against all Enterobacteriaceae (MIC50s, 0.06-2 micrograms/ml) except Enterobacter cloacae, Morganella morganii, Proteus vulgaris, and Serratia marcescens (MIC50s, greater than or equal to 4 micrograms/ml). Oxacillin-susceptible staphylococci (MIC90s, 0.5-2 micrograms/ml), beta-hemolytic Streptococcus group B (MIC90, 0.06 micrograms/ml), and Acinetobacter lwoffii were also susceptible to cefdinir. The activity of cefdinir was similar to that of cefixime and cefuroxime against Gram-negative organisms and superior to all tested oral cephems when tested against Gram-positive cocci. None of the cephalosporins were active against oxacillin-resistant Staphylococcus spp., enterococci, Pseudomonas spp., or Xanthomonas maltophilia. MIC quality control range guidelines were established for the strains recommended by the National Committee for Clinical Laboratory Standards documents.
Gerlach
E H
EH
Clinical Microbiology Laboratories, St. Francis Regional Medical Center, Wichita, KS 67214.
Jones
R N
RN
Allen
S D
SD
Koontz
F P
FP
Murray
P R
PR
Pfaller
M A
MA
Washington
J A
JA
Erwin
M E
ME
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002433:Cefaclor / Q000494:pharmacology; D002434:Cefadroxil / Q000494:pharmacology; D000077525:Cefdinir; D020682:Cefixime; D002439:Cefotaxime / Q000031:analogs & derivatives / Q000494:pharmacology; D002444:Cefuroxime / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004755:Enterobacteriaceae / Q000187:drug effects*; D006088:Gram-Negative Aerobic Bacteria / Q000187:drug effects*; D006095:Gram-Positive Cocci / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002434:Cefadroxil; D002433:Cefaclor; D020682:Cefixime; D000077525:Cefdinir; D002439:Cefotaxime; D002444:Cefuroxime