[Selective N-heterylazimine inhibition of reactions catalyzed by rat liver glutathione transferase].
Three reactions (nucleophile substitution, thiolysis and N-deoxygenation) catalyzed by rat liver glutathione transferase have been studied using several N-heterylazimine inhibitors. The inhibitors are sharply different in their effectiveness in the transferase reactions. Their efficiency depends on their structure. The mechanism which underlies the found regularities is suggested.
Stulovskiĭ
A V
AV
Voznyĭ
I V
IV
Rozengart
E V
EV
Suvorov
A A
AA
Khovanskikh
A E
AE
D000818:Animals; D002384:Catalysis; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors*; D008099:Liver / Q000201:enzymology*; D015394:Molecular Structure; D010100:Oxygen / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013438:Sulfhydryl Compounds / Q000378:metabolism
D013438:Sulfhydryl Compounds; D005982:Glutathione Transferase; D010100:Oxygen
Izbiratel'noe ingibirovanie N-geterilaziminami reaktsiĭ, kataliziruemykh glutationtransferazoĭ pecheni krysy.