Acetylenic glucosides from Microglossa pyrifolia.
From the leaves of Microglossa pyrifolia Lam. (Asteraceae) four new acetylenic glucosides (1-4) have been isolated. The aglucones 2a and 4a are new polyynes. The aglucone 3a could only be isolated as a mixture of E/Z-isomers in a ratio of 4:1. The structures of 1-4 were elucidated by spectroscopic and biochemical methods. Compound 1 shows antibacterial activity.
Rücker
G
G
Pharmazeutisches Institut, Rheinische Friedrich-Wilhelms-Universität Bonn, Federal Republic of Germany.
Kehrbaum
S
S
Sakulas
H
H
Lawong
B
B
Goeltenboth
F
F
D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010946:Plants, Medicinal / Q000737:chemistry*
D000890:Anti-Infective Agents; D006027:Glycosides