The pneumotoxicant paraquat potentiates IL-1 and TNF production by human mononuclear cells.
Interleukin 1 (IL-1) and tumor necrosis factor (TNF) have been implicated in the pathogenesis of bleomycin- and silica-induced lung damage. We have studied the effect of paraquat (PQ), a well-known pneumotoxicant, on IL-1 and TNF production by human peripheral blood mononuclear cells from different healthy donors stimulated with endotoxin. PQ (100 microM) potentiated IL-1 production (2-40 fold) and TNF production (2-18 fold). It is, therefore, possible that IL-1 and TNF are also involved in the pneumotoxic action of PQ.
Erroi
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A
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Bianchi
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Ghezzi
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D000918:Antibody Specificity; D003429:Cross Reactions; D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000096:biosynthesis*; D008070:Lipopolysaccharides; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism*; D010269:Paraquat / Q000494:pharmacology*; D011863:Radioimmunoassay; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D007375:Interleukin-1; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D010269:Paraquat