Mechanism of a clinically relevant protocol to induce tolerance: peritransplant spleen cells plus cyclosporine suppress IL-2 and IFN-gamma production.
Salom
R N
RN
Department of Pathology and Immunology, Monash Medical School, Melbourne, Victoria, Australia.
Maguire
J A
JA
Hancock
W W
WW
D000818:Animals; D016572:Cyclosporine / Q000494:pharmacology*; D006084:Graft Rejection / Q000276:immunology; D006085:Graft Survival / Q000187:drug effects / Q000502:physiology*; D016027:Heart Transplantation / Q000276:immunology* / Q000502:physiology; D007165:Immunosuppression Therapy / Q000379:methods*; D007371:Interferon-gamma / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis*; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D013154:Spleen / Q000166:cytology / Q000276:immunology / Q000637:transplantation*; D014184:Transplantation, Homologous; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000096:biosynthesis
D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma; D016572:Cyclosporine