Effects of baicalein and alpha-tocopherol on lipid peroxidation, free radical scavenging activity and 12-O-tetradecanoylphorbol acetate-induced ear edema.
The effects of baicalein, a flavonoid, and alpha-tocopherol (vitamin E) on lipid peroxidation in rat forebrain homogenates, on free radical scavenging action against diphenyl-p-picrylhydrazyl (DPPH), and on 12-O-tetradecanoylphorbol acetate (TPA)-induced ear edema in mice were studied. Baicalein inhibited lipid peroxidation in forebrain homogenates, DPPH-induced free radical and TPA-induced ear edema as potently as did quercetin and nordihydroguaiaretic acid (NDGA), a lipoxygenase inhibitor, and more potently than BW755C, a mixed cyclooxygenase and lipoxygenase inhibitor. Lipid peroxidation in forebrain homogenates, DPPH-induced free radical and TPA-induced ear edema were also inhibited by alpha-tocopherol. Flavone showed no reaction. These results suggest that lipid peroxidation may play an important role in the pathogenesis of TPA-induced ear edema in mice.
Hara
H
H
Department of Pharmacology, Kanebo Ltd., Osaka, Japan.
Sukamoto
T
T
Ohtaka
H
H
Abe
K
K
Tatumi
Y
Y
Saito
Y
Y
Suzuki
A
A
Tsukamoto
G
G
D000818:Animals; D004487:Edema / Q000139:chemically induced* / Q000473:pathology; D044950:Flavanones; D005419:Flavonoids / Q000494:pharmacology*; D016166:Free Radical Scavengers; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity*; D014810:Vitamin E / Q000494:pharmacology*
D044950:Flavanones; D005419:Flavonoids; D016166:Free Radical Scavengers; D014810:Vitamin E; C006680:baicalein; D013755:Tetradecanoylphorbol Acetate