Adrenalectomy aggravates ischemic brain edema in female Sprague-Dawley rats with carotid arteries ligated.
The effect of adrenalectomy has been investigated in a model of global cerebral ischemia. After bilateral carotid ligation the mortality rate was increased in adrenalectomized rats, and this effect was prevented by glucocorticoid pre-treatment. Adrenalectomy accelerated the appearance of the symptoms of cerebral ischemia, resulting in a moderate aggravation of brain edema and in a significant decrease in the concentration of high-energy phosphate esters. Our findings support the view that endogenous glucocorticoids may play a role in the amelioration of ischemic brain injuries in rats.
Abrahám
C
C
Department of Pharmacology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Koltai
M
M
Joó
F
F
Tósaki
A
A
Szerdahelyi
P
P
D000315:Adrenalectomy; D000818:Animals; D001929:Brain Edema / Q000503:physiopathology*; D002339:Carotid Arteries / Q000502:physiology*; D003907:Dexamethasone / Q000494:pharmacology*; D005260:Female; D002546:Ischemic Attack, Transient / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values
D003907:Dexamethasone