title: Recent advances in the electrophysiological characterization of 5-HT3 receptors.
abstract: 5-HT3 receptors are ligand-gated, cation-selective ion channels, mediating membrane depolarization and neuronal excitation. Established and potential therapeutic applications of selective 5-HT3 receptor antagonists, coupled with the localization of this receptor subtype within discrete areas of the CNS, have resulted in an intensification of research in this area. In this review, Jeremy Lambert and colleagues summarize recent developments in the electrophysiological characterization of 5-HT3 receptors, and comment upon the unresolved issue of 5-HT3 receptor heterogeneity.
authors.affiliation: Department of Pharmacology and Clinical Pharmacology, Ninewells Hospital and Medical School, The University, Dundee, UK.
authors.forename: J A
authors.initials: JA
authors.lastname: Peters
authors.forename: H M
authors.initials: HM
authors.lastname: Malone
authors.forename: J J
authors.initials: JJ
authors.lastname: Lambert
mesh_terms: D000818:Animals; D004594:Electrophysiology; D011985:Receptors, Serotonin / Q000145:classification* / Q000502:physiology
chemical_list: D011985:Receptors, Serotonin