Localisation of striatal muscarinic receptors involved in dopamine receptor-mediated behavioural responses.
Stereotyped sniffing responses to the direct dopamine agonist, apomorphine, were assessed following intrastriatal injection of the alkylating derivative of oxotremorine, BR 401. Subsequently, the localisation and extent of muscarinic receptor alkylation after injection into various striatal sites were assessed by quantitative autoradiography. The results of these experiments provide evidence that a regional subset of striatal muscarinic receptors is involved in apomorphine-induced stereotyped sniffing. In addition, these receptors are localised in a similar area to that previously shown to contain the dopamine D2 receptors responsible for mediating apomorphine-induced sniffing. Thus, striatal muscarinic receptors involved in dopamine-agonist induced behaviours share a close anatomical association with the dopamine receptors at which the agonist acts.
Crocker
A D
AD
Department of Clinical Pharmacology, Flinders University of South Australia, Adelaide.
Cameron
D L
DL
D000818:Animals; D001345:Autoradiography; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D003342:Corpus Striatum / Q000378:metabolism*; D007477:Ions; D008297:Male; D010095:Oxotremorine / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011954:Receptors, Dopamine / Q000378:metabolism / Q000502:physiology*; D011976:Receptors, Muscarinic / Q000378:metabolism*; D013239:Stereotyped Behavior / Q000187:drug effects / Q000502:physiology*; D014018:Tissue Distribution
D007477:Ions; C051445:N-(4-(2-bromoethylmethylamino)-2-butynyl)-2-pyrrolidone; D011954:Receptors, Dopamine; D011976:Receptors, Muscarinic; D010095:Oxotremorine