title: Interactions of selected insect neuropeptides with synthetic lipids.
abstract: Interactions of the insect neuropeptide proctolin (Arg-Tyr-Leu-Pro-Thr), its [beta-cyclohexyl-(4-O-methyl)2]-L-alanine analog, and the leucopyrokinin [2-8]-fragment (Thr-Ser-Phe-Thr-Pro-Arg-Leu-NH2), with synthetic phospholipids (DPPC, DMPE, DMPG) were studied using the microcalorimetric method. Most pronounced changes of the lipid thermotropic behavior were observed with DMPG/leucopyrokinin [2-8]-fragment mixtures. Proctolin itself was less active with all the lipids studied. The results obtained suggest that the studied peptides interact with the head group region of lipid bilayer.
authors.affiliation: Department of Biophysics, Academy of Medicine, Wrocław, Poland.
authors.forename: A B
authors.initials: AB
authors.lastname: Hendrich
authors.forename: D
authors.initials: D
authors.lastname: Konopinska
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002151:Calorimetry; D007301:Insect Hormones / Q000737:chemistry*; D007313:Insecta; D008051:Lipid Bilayers; D008969:Molecular Sequence Data; D009479:Neuropeptides / Q000737:chemistry*; D009842:Oligopeptides / Q000737:chemistry; D010446:Peptide Fragments / Q000737:chemistry; D010743:Phospholipids / Q000737:chemistry*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives
chemical_list: D007301:Insect Hormones; D008051:Lipid Bilayers; D009479:Neuropeptides; D009842:Oligopeptides; D010446:Peptide Fragments; D010743:Phospholipids; C049557:leucopyrokinin; C011536:proctolin; D011761:Pyrrolidonecarboxylic Acid