Evaluation of interceed(TC7) for reduction of postoperative adhesions in rabbits.
OBJECTIVE
To evaluate the effectiveness of Interceed(TC7) (Johnson and Johnson, New Brunswick, NJ) in the prevention of postoperative adhesions in a rabbit uterine horn model. Interceed(TC7) was tested in the presence and absence of absorbable suture.


METHODS
Forty-one New Zealand white rabbits had lesions created on bilateral uterine horns at laparotomy. Lesions were randomly allocated to treatment with Interceed(TC7) or control. The effect of Interceed(TC7) was evaluated on sutured lesions (4-0 polyglactin 910; Ethicon, Inc., Somerville, NJ) as well as on open cut lesions (no sutures applied).


METHODS
Adhesion formation, using a grading system ranging from 0 to 3.


RESULTS
Interceed(TC7)-treated animals in the sutured group (average adhesion score +/- SD = 2.15 +/- 1.3) did not differ from controls (average score +/- SD = 2.35 +/- 0.93) in adhesion formation, P = 0.47. Rabbits with open cut lesions treated with Interceed(TC7) (average adhesion score +/- SD = 1.89 +/- 1.1) did not differ from control animals (average score +/- SD = 1.83 +/- 1.2), P = 0.88.


CONCLUSIONS
Interceed(TC7) was not an effective adhesioprophylactic agent in the presence or absence of nonreactive absorbable suture.
Best
C L
CL
Valley Medical Center, Fresno, California.
Rittenhouse
D
D
Vasquez
C
C
Norng
T
T
Subias
E
E
Sueldo
C E
CE
D000818:Animals; D002483:Cellulose, Oxidized; D005069:Evaluation Studies as Topic; D005260:Female; D011183:Postoperative Complications / Q000517:prevention & control*; D011817:Rabbits; D000267:Tissue Adhesions / Q000517:prevention & control*; D014591:Uterine Diseases / Q000517:prevention & control
D002483:Cellulose, Oxidized; C060002:INTERCEED