title: Cardiac rupture complicating hemorrhagic infarction after intracoronary thrombolysis.
abstract: An 80-year-old woman with acute myocardial infarct received intracoronary thrombolysis by a large dose of urokinase four hours after the onset of chest pain. Despite the patient having no chest pain after intracoronary thrombolysis and her general condition being stable, she died suddenly on the 4th hospital day. Autopsy revealed hemopericardium due to cardiac rupture, which occurred at the center of the transmural hemorrhagic infarction of the anteroseptal wall. The massive hemorrhagic infarction was promoted by reperfusion from thrombolytic therapy. She had also classic risk factors for cardiac rupture, such as hypertension, senility, female gender, and first acute myocardial infarct. Therefore, the present case demonstrated that hemorrhagic infarction increased the incidence of cardiac rupture.
authors.affiliation: Department of Pathology, National Cardiovascular Center, Osaka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ishibashi-Ueda
authors.forename: M
authors.initials: M
authors.lastname: Imakita
authors.forename: H
authors.initials: H
authors.lastname: Fujita
authors.forename: M
authors.initials: M
authors.lastname: Katsuragi
authors.forename: C
authors.initials: C
authors.lastname: Yutani
mesh_terms: D000368:Aged; D003645:Death, Sudden; D005260:Female; D006341:Heart Rupture / Q000209:etiology* / Q000473:pathology; D006346:Heart Septum / Q000473:pathology; D006470:Hemorrhage / Q000473:pathology; D006801:Humans; D009203:Myocardial Infarction / Q000150:complications* / Q000188:drug therapy; D015424:Reperfusion; D012307:Risk Factors; D015912:Thrombolytic Therapy / Q000009:adverse effects*; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage
chemical_list: D014568:Urokinase-Type Plasminogen Activator