title: Olvanil: more potent than capsaicin at stimulating the efferent function of sensory nerves.
abstract: The capsaicin analogue olvanil stimulated an increase in cutaneous blood flow when injected intradermally into the anaesthetised rabbit, as measured using a 133Xenon clearance method. Olvanil was found to be a 10-fold more potent vasodilator (on a molar basis) than capsaicin. The effect of both vasodilators was significantly inhibited by the calcitonin gene-related peptide (CGRP) receptor antagonist CGRP-(8-37). These findings suggest that olvanil stimulates the efferent function of cutaneous sensory nerves in a more potent manner than capsaicin. We therefore suggest that olvanil is a useful pharmacological tool for studying the activity of neuropeptides released from sensory nerves.
authors.affiliation: Biomedical Sciences Division, King's College, London, UK.
authors.forename: S R
authors.initials: SR
authors.lastname: Hughes
authors.forename: T L
authors.initials: TL
authors.lastname: Buckley
authors.forename: S D
authors.initials: SD
authors.lastname: Brain
mesh_terms: D000758:Anesthesia; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001775:Blood Circulation / Q000187:drug effects*; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism; D002211:Capsaicin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004525:Efferent Pathways / Q000187:drug effects; D007271:Injections, Intradermal; D009475:Neurons, Afferent / Q000187:drug effects*; D011817:Rabbits; D014980:Xenon Radioisotopes
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D014980:Xenon Radioisotopes; C054256:olvanil; D015740:Calcitonin Gene-Related Peptide; D002211:Capsaicin