Chronic neutrophilic leukemia (CNL) with karyotypic abnormalities associated with plasma cell dyscrasia: a case report.
A case of chronic neutrophilic leukemia (CNL), a rare myeloproliferative syndrome associated with monoclonal gammopathy of uncertain significance (MGUS-Type IgGk), is reported. Karyotypic study, carried out on bone marrow, excluded Philadelphia-pos. chronic myeloid leukemia (CML) and showed Y loss (45 XO). Only a few cases of CNL with paraproteinemia have been reported, but no case of associated karyotypic abnormalities and paraproteinemia has so far been described.
Masini
L
L
I Divisione Medica, Arcispedale S. Maria Nuova, Reggio Emilia, Italy.
Salvarani
C
C
Macchioni
P
P
Baldi
G
G
Rossi
F
F
Croci
G
G
Prandi
S
S
Davoli
C
C
Portioli
I
I
Gobbi
F
F
D000368:Aged; D002872:Chromosome Deletion; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007145:Immunoglobulin kappa-Chains / Q000097:blood*; D007621:Karyotyping; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Q000150:complications* / Q000235:genetics; D015467:Leukemia, Neutrophilic, Chronic / Q000150:complications* / Q000235:genetics; D008297:Male; D010265:Paraproteinemias / Q000209:etiology*; D014998:Y Chromosome
D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains