A study of Helicobacter pylori in north Indian subjects with non-ulcer dyspepsia.
A prospective case control study was conducted in 50 patients with non-ulcer dyspepsia (NUD) and 10 age and sex matched controls to determine the prevalence of Helicobacter pylori in patients with NUD and to correlate symptoms, histology and presence of H pylori in gastric biopsies. Endoscopic biopsies from antrum and fundus were subjected to urease test and histological examination. On histology, H pylori was identified in 27 (54%) NUD patients and in one of 10 controls. Urease test was positive in 31 (62%) antral and 21 (42%) fundal biopsies in patients with NUD and in only one (10%) of 10 antral biopsies in the control group. On histology, gastritis was present in the antrum in 46 (92%) NUD patients and in the fundus in 40 (80%) cases; of these, 27 (54%) and 15 (30%) had H pylori in antral and fundal biopsies respectively. The severity of antral gastritis correlated with the density of H pylori (p < 0.05).
Mukhopadhyay
D K
DK
Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi.
Tandon
R K
RK
Dasarathy
S
S
Mathur
M
M
Wali
J P
JP
D000293:Adolescent; D000328:Adult; D004415:Dyspepsia / Q000382:microbiology* / Q000473:pathology; D005260:Female; D005756:Gastritis / Q000382:microbiology / Q000473:pathology; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies