Altered activity of hepatic mixed function oxidase, cytochrome P-450 and glutathione-S-transferase by styrene in rat fetal liver.
The effect of in utero exposure to styrene 200 or 400 mg/kg/day orally was studied on mixed function oxidase activities, cytochrome P-450 and glutathione contents and on the glutathione-S-transferase activity in rat fetal liver. Activities of aminopyrene-N-demethylase, aniline hydroxylase, aryl hydrocarbon hydroxylase and the cytochrome P-450 contents were significantly decreased in the fetal liver. A significant decrease in the glutathione contents and the glutathione-S-transferase activity was also observed in the liver of the fetuses of styrene exposed animals. The current data show that prenatal exposure to styrene could adversely affect the developing biotransformation process.
Srivastava
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Industrial Toxicology Research Centre, Marg, Lucknow.
Seth
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Srivastava
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D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D005333:Fetus / Q000187:drug effects* / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005982:Glutathione Transferase / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000196:embryology / Q000201:enzymology*; D008297:Male; D006899:Mixed Function Oxygenases / Q000187:drug effects* / Q000378:metabolism; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D020058:Styrene; D013343:Styrenes / Q000494:pharmacology*
D013343:Styrenes; D020058:Styrene; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D005982:Glutathione Transferase; D005978:Glutathione