Folding kinetics of designer proteins. Application of the diffusion-collision model to a de novo designed four-helix bundle.
A folding algorithm is described, based on the diffusion-collision model, combining static and dynamic calculational methods. The algorithm is applied to predict the basic structure and schematic folding pathways of an artificial four-helix bundle.
Yapa
K K
KK
Department of Physics, Tufts University, Medford, Massachusetts 02155.
Weaver
D L
DL
D000595:Amino Acid Sequence; D055592:Biophysical Phenomena; D001703:Biophysics; D004058:Diffusion; D015195:Drug Design; D007700:Kinetics; D008956:Models, Chemical; D008969:Molecular Sequence Data; D011487:Protein Conformation; D015202:Protein Engineering; D011506:Proteins / Q000737:chemistry*
D011506:Proteins