[Cerebral blood flow. Changes in regulation with aging].
In subjects without cardiovascular or neuronal diseases ageing does not seem to be accompanied by a significant fall in global cerebral blood flow at rest. Yet non-negligible changes in cerebral blood flow rate can be demonstrated by haemodynamic or metabolic stimuli. Several intra- and extracranial vascular mechanisms may be involved in these changes. During ageing, a decrease of carotid artery compliance due to parietal calcium deposition might be an important factor in the disturbance of cerebral blood flow regulatory mechanisms.
Atkinson
J
J
Laboratoire de Pharmacologie cardiovasculaire, Faculté de Pharmacie, Nancy.
Lartaud
I
I
Capdeville-Atkinson
C
C
D000375:Aging / Q000473:pathology / Q000502:physiology*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000818:Animals; D001158:Arteries / Q000503:physiopathology; D001783:Blood Flow Velocity / Q000502:physiology*; D002114:Calcinosis / Q000150:complications; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002561:Cerebrovascular Disorders / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D006935:Hypercapnia / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D014652:Vascular Diseases / Q000150:complications
D000806:Angiotensin-Converting Enzyme Inhibitors
Débit sanguin cérébral. Evolution de la régulation avec l'âge.