title: Transverse cerebellar diameter measurements in twin pregnancies and the effect of intrauterine growth retardation.
abstract: OBJECTIVE
  Transverse cerebellar diameter measurements have been established for singleton but not twin pregnancies. In singleton pregnancies controversy exists on whether cerebellar growth is affected by intrauterine growth retardation. We undertook this retrospective study in twin pregnancies to establish a nomogram for the transverse cerebellar diameter in twins and to assess the effect of growth retardation on this measurement.
  
  
  METHODS
  A retrospective review was performed on 171 patients with twin pregnancies with reliable dating from 15 to 36 weeks' gestation who had been referred to our antenatal evaluation unit for routine ultrasonographic examination. Of the 342 fetuses, 322 were available for analysis and establishment of a nomogram for the transverse cerebellar diameter. Twenty-four twin, growth-retarded fetuses were analyzed separately.
  
  
  RESULTS
  The transverse cerebellar diameter increased linearly with gestational age (r = 0.94, p < 0.001). Fifteen (63%) of the growth-retarded fetuses had a transverse cerebellar diameter of < or = 5th percentile for gestational age.
  
  
  CONCLUSIONS
  We suggest that intrauterine growth retardation may affect cerebellar growth in twins.
authors.affiliation: Department of Obstetrics and Gynecology, University of Connecticut Health Center, Farmington.
authors.forename: L
authors.initials: L
authors.lastname: Lettieri
authors.forename: A M
authors.initials: AM
authors.lastname: Vintzileos
authors.forename: J F
authors.initials: JF
authors.lastname: Rodis
authors.forename: J F
authors.initials: JF
authors.lastname: Egan
authors.forename: E J
authors.initials: EJ
authors.lastname: Wolf
authors.forename: D A
authors.initials: DA
authors.lastname: McLean
mesh_terms: D002531:Cerebellum / Q000000981:diagnostic imaging / Q000196:embryology*; D005260:Female; D005317:Fetal Growth Retardation / Q000196:embryology*; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D011272:Pregnancy, Multiple; D012189:Retrospective Studies; D014427:Twins; D016216:Ultrasonography, Prenatal