Sorption studies of dipotassium clorazepate salt (Tranxène) and midazolam hydrochloride (Hypnovel) in polyvinyl chloride and glass infusion containers.
The compatibilities of dipotassium clorazepate and midazolam hydrochloride with polyvinyl chloride (PVC) bags have been studied and compared with those observed with glass flasks. At room temperature, dipotassium clorazepate showed chemical instability which was independent of the container. At 4 degrees C, dipotassium clorazepate showed no decrease in concentration over 12 h, both in 5% dextrose solution and 0.9% sodium chloride solutions. When stored for longer periods of up to 72 h, a slight decrease not exceeding 5% was observed. The compatibility of midazolam with the PVC bags was found to be good at room temperature. It was slightly better in 5% dextrose solution than in 0.9% sodium chloride solution. High sorption of the drug was observed at pH 7.0 when the primary ring structure is maintained. The results make it possible for the hospital pharmacist to prepare dipotassium chlorazepate salt and midazolam admixtures up to 3 days before administration, provided the former are stocked in a refrigerator and the latter are prepared in dextrose isotonic solutions.
Bianchi
C
C
Pharmacy of Centre Hospitalier Spécialisé Valvert, Marseilles, France.
Airaudo
C B
CB
Gayte-Sorbier
A
A
D002626:Chemistry, Pharmaceutical; D003009:Clorazepate Dipotassium / Q000737:chemistry*; D003080:Cold Temperature; D005898:Glass / Q000737:chemistry*; D005947:Glucose / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007552:Isotonic Solutions; D008874:Midazolam / Q000737:chemistry*; D011143:Polyvinyl Chloride / Q000737:chemistry*
D007552:Isotonic Solutions; D003009:Clorazepate Dipotassium; D011143:Polyvinyl Chloride; D005947:Glucose; D008874:Midazolam