title: Fibrinolytic activity as a predictor of the outcome of prolapsed intervertebral lumbar disc surgery with reference to background variables: results of a prospective cohort study.
abstract: In a prospective study 122 patients with a slipped lumbar disc and no previous surgery were preoperatively examined for fibrinolytic activity. Surgical results for these patients were evaluated 12 months postoperatively by clinical overall assessment. In a multiple linear regression analysis fibrinolytic variables, euglobulin clot lysis time and plasminogen activator inhibitor 1, were shown to have predictive value regarding outcome of surgery; that is, normal fibrinolytic activity favors a satisfactory outcome and vice versa. Background variables and lipid profile were also recorded preoperatively. Body mass index, gamma-glutamyl transpeptidase, triglycerides and smoking were of statistical significance in relation to euglobulin clot lysis time and plasminogen activator inhibitor 1. Postoperative fibrinolytic re-examination of 20 patients seem to confirm that patients at risk of surgical failure have a prolonged depression of fibrinolytic activity.
authors.affiliation: Ullevål University Hospital, Oslo, Norway.
authors.forename: A K
authors.initials: AK
authors.lastname: Haaland
authors.forename: V
authors.initials: V
authors.lastname: Graver
authors.forename: A E
authors.initials: AE
authors.lastname: Ljunggren
authors.forename: M
authors.initials: M
authors.lastname: Loeb
authors.forename: H
authors.initials: H
authors.lastname: Lie
authors.forename: B
authors.initials: B
authors.lastname: Magnaes
authors.forename: H C
authors.initials: HC
authors.lastname: Godal
mesh_terms: D015331:Cohort Studies; D005342:Fibrinolysis; D005544:Forecasting; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000097:blood / Q000503:physiopathology / Q000601:surgery*; D008159:Lumbar Vertebrae; D015849:Plasminogen Inactivators / Q000097:blood; D011184:Postoperative Period; D011446:Prospective Studies; D012044:Regression Analysis; D010959:Tissue Plasminogen Activator / Q000097:blood
chemical_list: D015849:Plasminogen Inactivators; D010959:Tissue Plasminogen Activator