Human recombinant interleukin-1 alpha and beta and articular tissue integrity. An in vivo study on hens and rats.
Human recombinant interleukin-1 alpha or beta was injected intraarticularly several times into the knee joints of rats and hens at different dosages (50-2000 ng) and intervals. No loss of cartilage detectable by width of the radiological joint space and no degenerative changes of subchondral bone could be observed during 16 weeks using X-ray analysis. The macroscopical examination of articular cartilage of hens after this period and of rats after one year showed no morphological cartilage damages. These data suggest that human recombinant Il-1 alpha and beta alone may not be sufficient to induce a progressing osteoarthritic process in these animals.
Schug
B S
BS
Institute of Pharmacology and Toxicology, University of Bonn, Fed. Rep. of Germany.
Kalbhen
D A
DA
D000818:Animals; D001175:Arthrography; D002358:Cartilage, Articular / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology; D002645:Chickens; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular; D007375:Interleukin-1 / Q000008:administration & dosage / Q000633:toxicity*; D007596:Joints / Q000187:drug effects / Q000473:pathology; D010003:Osteoarthritis / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000473:pathology; D051381:Rats; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000633:toxicity
D007375:Interleukin-1; D011994:Recombinant Proteins