[Features of metabolic disorders in the liver during morphine poisoning of various duration].
Administration of morphine into rats at a dose of 30 mg/kg within 6 days led to a decrease in total rate of tRNA aminoacylation in liver tissue. Content of lactate, pyruvate, malate and alpha-ketoglutarate was decreased within 6 days-long course of morphine administration, while content of lactate was only altered after 5 weeks of the intoxication. Adaptation reactions appear to be increased with time in long-term intoxication with morphine.
Gulyĭ
M F
MF
Sinitskiĭ
V N
VN
Stogniĭ
N A
NA
Sushkova
V V
VV
Silonova
N V
NV
Shevtsova
N F
NF
Kas'ianova
N N
NN
D000818:Animals; D002952:Citric Acid Cycle; D004734:Energy Metabolism; D006019:Glycolysis; D008099:Liver / Q000378:metabolism*; D008297:Male; D009020:Morphine / Q000506:poisoning*; D014176:Protein Biosynthesis; D012346:RNA, Transfer, Amino Acyl / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D012346:RNA, Transfer, Amino Acyl; D009020:Morphine
Osobennosti metabolicheskikh narusheniĭ v pechenii pri morfinnoĭ intoksikatsii razlichnoĭ dlitel'nosti.