Murine survival of lethal irradiation with the use of human umbilical cord blood.
We have found that human umbilical cord blood (HUCB) will routinely protect mice exposed to lethal levels of irradiation. At the end of 50 days, over seventy percent (70%) of mice injected with HUCB survived 900 cGy or irradiation, which produced 100% deaths in the uninjected control animals. Moreover, there was some evidence that human colony stimulating factors further improved survival. Anti-Natural Killer cell (NK) antibody was utilized along with HUCB in these studies, however, Anti-NK cell serum alone had no radioprotective effect in mice. The studies reported here suggest the possibility of utilizing HUCB for immediate protection of humans from lethal irradiation.
Ende
N
N
UMDNJ, New Jersey Medical School, Newark 07103-2714.
Ponzio
N M
NM
Athwal
R S
RS
Ende
M
M
Giuliani
D C
DC
D000818:Animals; D003115:Colony-Stimulating Factors / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003524:Cyclosporins / Q000627:therapeutic use*; D005312:Fetal Blood; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains; D011833:Radiation Injuries, Experimental / Q000628:therapy*; D016019:Survival Analysis
D003115:Colony-Stimulating Factors; D003524:Cyclosporins