Growth hormone gene regulation by trans-acting factors.
The promoter sequence of the growth hormone (GH) gene binds the ubiquitous factors nuclear factor 1, activator protein-2, upstream stimulatory factor and Sp1. A pituitary-specific factor known as growth hormone factor 1 or Pit-1 also binds to the promoter sequence. This factor is responsible for somatotroph-specific expression of GH. It is also involved in the effect of GH-releasing hormone and in the ontogeny of the anterior pituitary.
Rousseau
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Hormone and Metabolic Research Unit, University of Louvain Medical School, Brussels, Belgium.
D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D005786:Gene Expression Regulation; D013006:Growth Hormone / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D015534:Trans-Activators / Q000235:genetics*; D050817:Transcription Factor Pit-1; D014157:Transcription Factors / Q000235:genetics; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; C494187:POU1F1 protein, human; D015534:Trans-Activators; D050817:Transcription Factor Pit-1; D014157:Transcription Factors; D013006:Growth Hormone; D004247:DNA