Adaptive computer program for determination of absorption profiles by numerical deconvolution: application to amoxicillin absorption.
We have developed a specific numerical deconvolution program for the Apple Macintosh microcomputer. After comparison with other methods, we used the program to evaluate the influence of nifedipine on the absorption and bioavailability of amoxicillin. The technique provided a model-independent approach. This study shows that the simultaneous administration of nifedipine with amoxicillin leads to a significant increase in both the total quantity of amoxicillin absorbed (+22%) and the rate of absorption. Parameters of clearance, volume of distribution, and elimination were unaffected. Numerical deconvolution analysis showed that nifedipine did not modify the absorption kinetics of amoxicillin, which are characterized by a lag time followed by a constant rate of absorption, suggesting zero-order kinetics with first-order kinetics at the end of the process. The results suggest the existence of a specialized, saturable transport molecule for this antibiotic.
Deslandes
A
A
Service de Pharmacie Clinique et des Biomatériaux, C.H.U. Xavier Bichat, Paris, France.
Westphal
J F
JF
Trouvin
J H
JH
Farinotti
R
R
D000328:Adult; D000658:Amoxicillin / Q000493:pharmacokinetics*; D001682:Biological Availability; D006801:Humans; D007275:Injections, Intravenous; D007408:Intestinal Absorption / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008432:Mathematical Computing; D008838:Microcomputers; D009543:Nifedipine / Q000494:pharmacology; D012984:Software; D014018:Tissue Distribution / Q000187:drug effects
D000658:Amoxicillin; D009543:Nifedipine