title: Reversal of food restriction-induced inhibition of mouse skin tumor promotion by adrenalectomy.
abstract: Restricting the food intake of laboratory mice and rats markedly reduces the incidence of spontaneous and experimentally induced cancers. Using the two-stage skin tumorigenesis model in CD-1 mice, we report now that food restriction suppresses 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation of epidermal [3H]thymidine incorporation as well as TPA promotion of skin papillomas, whereas adrenalectomy completely reverses the inhibition in [3H]thymidine incorporation and tumor development. These results suggest that the adrenal gland may play an important role in mediating the tumor inhibitory effect of food restriction.
authors.affiliation: Feis Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140.
authors.forename: L L
authors.initials: LL
authors.lastname: Pashko
authors.forename: A G
authors.initials: AG
authors.lastname: Schwartz
mesh_terms: D000311:Adrenal Glands / Q000502:physiology / Q000601:surgery; D000315:Adrenalectomy; D000818:Animals; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D003345:Corticosterone / Q000097:blood; D004273:DNA, Neoplasm / Q000096:biosynthesis; D003687:Dehydroepiandrosterone / Q000494:pharmacology; D005260:Female; D005502:Food; D051379:Mice; D008815:Mice, Inbred Strains; D010212:Papilloma / Q000139:chemically induced / Q000178:diet therapy*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000178:diet therapy* / Q000209:etiology; D013268:Stimulation, Chemical; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D004273:DNA, Neoplasm; D003687:Dehydroepiandrosterone; D013755:Tetradecanoylphorbol Acetate; D003345:Corticosterone