title: Bacterial acetylation of 5-aminosalicylic acid in faecal suspensions cultured under aerobic and anaerobic conditions.
abstract: After oral administration of 5-aminosalicylic acid a substantial proportion of the acetylated form is excreted in the faeces. We have studied the role of the faecal microflora in acetylating 5-aminosalicylic acid. In faeces incubated under both aerobic and anaerobic conditions there was acetylation of 5-aminosalicylic acid. Of the anaerobic bacteria isolated from a 10(8) faecal dilution 44% were able to acetylate 5-aminosalicylic acid. We conclude that the normal faecal microflora contribute to the acetylation of 5-aminosalicylic acid.
authors.affiliation: Department of Medicine, St. Radboud Hospital, Nijmegen, The Netherlands.
authors.forename: R A
authors.initials: RA
authors.lastname: van Hogezand
authors.forename: H M
authors.initials: HM
authors.lastname: Kennis
authors.forename: A
authors.initials: A
authors.lastname: van Schaik
authors.forename: J P
authors.initials: JP
authors.lastname: Koopman
authors.forename: P A
authors.initials: PA
authors.lastname: van Hees
authors.forename: J H
authors.initials: JH
authors.lastname: van Tongeren
mesh_terms: D000107:Acetylation; D000332:Aerobiosis; D000636:Aminosalicylic Acids / Q000378:metabolism*; D000693:Anaerobiosis; D001419:Bacteria / Q000378:metabolism*; D001431:Bacteriological Techniques; D005243:Feces / Q000382:microbiology*; D006801:Humans; D019804:Mesalamine
chemical_list: D000636:Aminosalicylic Acids; D019804:Mesalamine