Antithrombin III deficiency and cerebrovascular accidents in young adults.
A young man with antithrombin III (AT-III) deficiency sustained a cerebellar venous infarct and recovered following treatment with AT-III concentrate. A family study showed that other members were affected. AT-III deficiency in this family was found to be due to a new variant AT-III TRURO 1. Young patients with strokes should be screened for thrombophilia.
Graham
J A
JA
Department of Haematology, Royal Cornwall Hospital, Treliske, Truro.
Daly
H M
HM
Carson
P J
PJ
D000328:Adult; D000990:Antithrombin III / Q000627:therapeutic use; D020152:Antithrombin III Deficiency; D002531:Cerebellum / Q000000981:diagnostic imaging; D002561:Cerebrovascular Disorders / Q000209:etiology*; D006801:Humans; D008297:Male; D010375:Pedigree; D013924:Thrombophlebitis / Q000209:etiology; D014057:Tomography, X-Ray Computed
D000990:Antithrombin III