Effect of ACE inhibition on the fetal kidney: decreased renal blood flow.
The kidneys of nine fetuses whose mothers were chronically hypertensive were examined microscopically. Three of these mothers used antihypertensive agents throughout pregnancy including one who used an angiotensin-converting enzyme (ACE) inhibitor. The tubular defects found in these kidneys were compared to the kidneys of 20 normal controls, 13 fetuses with various multiple malformation syndromes and six cases of the twin to twin transfusion syndrome. Evidence from these cases as well as the literature suggest that the primary mechanism by which ACE inhibitors affect development of the fetal kidney is through decreased renal blood flow.
Martin
R A
RA
Department of Pediatrics, University of California Medical Center, San Diego 92103.
Jones
K L
KL
Mendoza
A
A
Barr
M
M
Benirschke
K
K
D000014:Abnormalities, Drug-Induced / Q000209:etiology* / Q000473:pathology; D000015:Abnormalities, Multiple / Q000473:pathology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects* / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005315:Fetal Diseases / Q000139:chemically induced* / Q000473:pathology; D005330:Fetofetal Transfusion / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007231:Infant, Newborn; D007674:Kidney Diseases / Q000139:chemically induced* / Q000196:embryology / Q000473:pathology; D007684:Kidney Tubules / Q000002:abnormalities* / Q000187:drug effects / Q000196:embryology / Q000473:pathology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy*; D012079:Renal Circulation / Q000187:drug effects*; D014430:Twins, Monozygotic
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents