Regulation of DNA replication by the nuclear envelope.
Recent evidence suggests that the nuclear envelope is directly involved in regulating DNA replication. It does this in at least three ways. First, replication is dependent on assembly of an intact nuclear envelope capable of nuclear transport. Second, the nuclear membrane defines the nucleus as the fundamental unit of replication and determines the timing of initiation. Third, the nuclear membrane is essential for coupling DNA replication to the cell cycle. Thus, regulated DNA replication in eukaryotic cells depends on a structurally intact and functional nuclear envelope.
Leno
G H
GH
Wellcome/CRC Institute of Cancer and Developmental Biology, University of Cambridge, UK.
D000818:Animals; D001692:Biological Transport; D004261:DNA Replication; D009685:Nuclear Envelope / Q000502:physiology*; D016196:S Phase; D014981:Xenopus / Q000196:embryology; D015053:Zygote / Q000378:metabolism