[Molecular bases of cardiac aging].
The total volume occupied by myocytes in the heart decreases with age, and this is accompanied by a loss of myocytes, by hypertrophy and, to a lesser extent, by hyperplasia of the remaining myocytes. There are differences between ventricles: the right ventricular myocytes have a greater capacity for replication than those of the left ventricle. The expression of genes coding for the 2 principal contractile proteins (myosin and actin) is modified, and there are strong resemblances between the phenotype of the aged heart and that of an adult heart with haemodynamic overload.
Carrier
L
L
INSERM U127, Hôpital Lariboisière, Paris.
Chassagne
C
C
Boheler
K R
KR
Schwartz
K
K
D000199:Actins / Q000235:genetics / Q000502:physiology; D000328:Adult; D000368:Aged; D000375:Aging / Q000473:pathology / Q000502:physiology*; D006332:Cardiomegaly / Q000503:physiopathology*; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D009218:Myosins / Q000235:genetics / Q000502:physiology; D010641:Phenotype
D000199:Actins; D009218:Myosins
Bases moléculaires du vieillissement cardiaque.