Antidiabetic effect of a glycoside of pelargonidin isolated from the bark of Ficus bengalensis Linn.
The antidiabetic effect of a dimethoxy derivative of perlargonidin 3-O-alpha-L rhamnoside (250 mg/kg, single dose study and 100 mg/kg/day long term study) isolated from the bark of Ficus bengalensis Linn. has been compared with that of glibenclamide (2 mg/kg and 0.5 mg/kg/day respectively) in moderately diabetic rats. The single dose glycoside treatment decreased fasting blood glucose by 19% and improved glucose tolerance by 29%. The corresponding effects of glibenclamide were 25% and 66% respectively over the control values. On one-month treatment the fasting blood glucose levels went down almost to half of the pretreatment levels in both the groups and their glucose tolerance improved by 41% in glibenclamide group and by 15% in glycoside treated group. Urine sugar decreased to traces in both the groups and they appeared healthy. In vitro studies showed that insulin secretion by beta-cells was more in presence of the pelargonidin derivative than in presence of a leucocyanidin derivative, reported to be a good anti-diabetic agent.
Cherian
S
S
Department of Biochemistry, University of Kerala, Thiruvananthapuram.
Kumar
R V
RV
Augusti
K T
KT
Kidwai
J R
JR
D000818:Animals; D000872:Anthocyanins; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D005419:Flavonoids / Q000494:pharmacology*; D005905:Glyburide / Q000494:pharmacology; D006027:Glycosides / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
D000872:Anthocyanins; D001786:Blood Glucose; D005419:Flavonoids; D006027:Glycosides; D007004:Hypoglycemic Agents; D007328:Insulin; D010936:Plant Extracts; C066957:pelargonidin; C001532:leucocyanidin; D005905:Glyburide