title: Systemic IL-1 and adjuvant treatment of an experimental tumor. I. Immune status following tumor rechallenge.
abstract: Local adjuvant therapy of weakly immunogenic tumors protects against primary tumor challenge. However, this form of therapy does not produce long-lasting immunity to the tumor. In this study, local adjuvant therapy combined with systemic IL-1 administration produced not only primary tumor protection, but also long lasting immunity to the tumor. IL-1 and adjuvant protected animals resisted rechallenge with tumor as much as 180 days after initial tumor administration. Resistance to tumor rechallenge was IL-1 dose dependent. IL-1 and adjuvant protected animals also exhibited delayed type hypersensitivity reactions which were tumor-specific. Splenic and lymph node cell populations from IL-1 and adjuvant protected animals mounted tumor-specific lymphoproliferative responses. No such responses were observed in animals which had been administered either IL-1 or adjuvant alone. These results demonstrate that systemic IL-1 functions to augment specific immune protection when administered in conjunction with local adjuvant, resulting in long-lasting tumor immunity.
authors.affiliation: Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University of Chicago, Maywood, IL 60153.
authors.forename: R L
authors.initials: RL
authors.lastname: Hornung
authors.forename: S M
authors.initials: SM
authors.lastname: Kiertscher
authors.forename: H L
authors.initials: HL
authors.lastname: Mathews
mesh_terms: D000818:Animals; D017024:Chemotherapy, Adjuvant; D005260:Female; D007375:Interleukin-1 / Q000627:therapeutic use*; D008213:Lymphocyte Activation; D008223:Lymphoma / Q000276:immunology; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000276:immunology / Q000628:therapy*; D011425:Propionibacterium acnes / Q000276:immunology; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D007375:Interleukin-1; D011994:Recombinant Proteins