[Effects of antibodies to lysosomal enzymes on the course of experimental burn shock].
On the model of burn shock in rats, the influence of antibodies to lysosomal enzymes has been studied in respect to the cathepsin D activity, oxygen regimen, acid-base equilibrium in blood, and animal survival. It has been shown that the antibodies inactivate the cathepsin D activity which is increased in burn shock. Because of the decreased cardiodepressant action of the lysosomal enzymes, the blood circulation improves, the manifestations of hypoxia and metabolic acidosis are attenuated. The results obtained confirm an important role of the lysosomal in the pathogenesis of bur, shock and permit one to consider its therapy using antibodies to the lysosomal enzymes to be promising.
Remizova
M I
MI
Makeev
A B
AB
D000136:Acid-Base Equilibrium; D000818:Animals; D000906:Antibodies / Q000276:immunology*; D002056:Burns / Q000276:immunology* / Q000378:metabolism; D002402:Cathepsin D / Q000276:immunology*; D005260:Female; D007136:Immunoglobulins / Q000008:administration & dosage*; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D051381:Rats; D012774:Shock, Traumatic / Q000209:etiology / Q000276:immunology* / Q000378:metabolism
D000906:Antibodies; D007136:Immunoglobulins; D002402:Cathepsin D
Vliianie antitel k fermentam lizosom na techenie ozhogovogo shoka v éksperimente.