title: Short report: comparison of the effects of sublingual nifedipine and isosorbide dinitrate on oesophageal emptying in patients with Chagasic achalasia.
abstract: The effects of sublingual nifedipine and isosorbide dinitrate on oesophageal emptying were compared in 11 patients with Chagasic achalasia. The oesophageal emptying of a radiolabelled test meal was assessed three times in each patient by a scintigraphic technique. No treatment preceded one of the studies (basal study). Nifedipine (20 mg) by the sublingual route 30 min before the meal, preceded one study. Isosorbide dinitrate, 5 mg by the sublingual route 5 min before the meal, preceded the third study. The order of the studies was allocated randomly for each patient. Oesophageal retention at the completion of the meal was significantly less (P less than 0.01) after isosorbide dinitrate (median: 54%, range: 5-87%) than after sublingual nifedipine (median: 78%, range: 7-99%) or after the control study (median: 83%, range: 5-100%). This difference persisted up to 20 min after the meal. Values measured in the control study and after sublingual nifedipine were not different (P greater than 0.10). These results show that isosorbide dinitrate, but not sublingual nifedipine, enhances oesophageal emptying in Chagasic achalasia.
authors.affiliation: Departamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, Brazil.
authors.forename: M C
authors.initials: MC
authors.lastname: Figueiredo
authors.forename: R B
authors.initials: RB
authors.lastname: Oliveira
authors.forename: N
authors.initials: N
authors.lastname: Iazigi
authors.forename: N M
authors.initials: NM
authors.lastname: Matsuda
mesh_terms: D000286:Administration, Sublingual; D000328:Adult; D000368:Aged; D014355:Chagas Disease / Q000188:drug therapy* / Q000503:physiopathology; D004931:Esophageal Achalasia / Q000188:drug therapy* / Q000503:physiopathology; D004947:Esophagus / Q000187:drug effects / Q000503:physiopathology; D005260:Female; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D009543:Nifedipine; D007548:Isosorbide Dinitrate