title: The preadministration of activated charcoal and aspirin absorption.
abstract: There is little information describing the effects of activated charcoal preadministration on drug absorption. This study was undertaken to determine the effect of activated charcoal preadministration at two different times on aspirin absorption. Fifteen volunteer subjects completed three study phases: 1) 975 mg aspirin alone, 2) 975 mg aspirin 30 min after 10 g activated charcoal, and 3) 975 mg aspirin 60 min after 10 g activated charcoal. Urine was collected for 48 h after the initiation of each study phase, and total aspirin recovery determined by HPLC. The aspirin recovery was 88.8% +/- 4.5% for the control phase, and 84.8% +/- 9.4% (Phase 1) and 85.8% +/- 12.6% (Phase 2) for the activated charcoal treatments (p > 0.05). These results suggest that activated charcoal administered 30 and 60 min prior to drug ingestion has little effect on drug absorption. Further studies of the effect of charcoal preadministration on the absorption of other drugs may provide useful information regarding factors important in determining activated charcoal efficacy.
authors.affiliation: Rocky Mountain Poison and Drug Center, Denver, Colorado.
authors.forename: P E
authors.initials: PE
authors.lastname: McKinney
authors.forename: R
authors.initials: R
authors.lastname: Gillilan
authors.forename: W A
authors.initials: WA
authors.lastname: Watson
mesh_terms: D000042:Absorption / Q000187:drug effects; D000284:Administration, Oral; D000328:Adult; D001241:Aspirin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D002606:Charcoal / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011897:Random Allocation
chemical_list: D002606:Charcoal; D001241:Aspirin