title: Mutagenic activity of copper(II) chromate and dichromate complexes with polypyridines.
abstract: Copper(II) chromate and dichromate complexes with 2,2'-bipyridyl and 1,10-phenathroline were tested for their mutagenic activity in the standard Ames test. All of six tested complexes exhibited markedly lower mutagenic activity than the reference compounds--potassium dichromate and sodium chromate. The blockage of Cr(VI) reduction capability in the presence of the complex Cu2+ ion and the competition between copper and chromium ions in the interaction with cellular components are discussed in the light of the results of our previous chemical study.
authors.affiliation: Department of Basic Medical Sciences, Medical Academy, Wrocław, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Szyba
authors.forename: M C
authors.initials: MC
authors.lastname: Golonka
authors.forename: K
authors.initials: K
authors.lastname: Gasiorowski
authors.forename: J
authors.initials: J
authors.lastname: Urban
mesh_terms: D015082:2,2'-Dipyridyl / Q000633:toxicity*; D002840:Chromates / Q000633:toxicity*; D003300:Copper / Q000633:toxicity*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D010084:Oxidation-Reduction; D010618:Phenanthrolines / Q000633:toxicity*; D011192:Potassium Dichromate / Q000633:toxicity; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D017670:Sodium Compounds
chemical_list: D002840:Chromates; D009153:Mutagens; D010618:Phenanthrolines; D017670:Sodium Compounds; D015082:2,2'-Dipyridyl; C028982:sodium chromate(VI); D003300:Copper; D011192:Potassium Dichromate; C025205:1,10-phenanthroline