[Pregnancy after renal transplantation. 27 patients and review of the literature].
We report the course and outcome of 30 pregnancies in 27 renal transplant patients between 1970 and 1988. Delay between transplantation and pregnancy was 7.3 +/- 4.8 years. There were 1 twin pregnancy and 3 successive pregnancies. Immunosuppressive regime was prednisone and azathioprine in 28 cases and cyclosporine in 2. Hypertension (33%), preterm delivery (74%) and premature rupture of the membranes (33%) were the main complication encountered. The cesarean section rate was 73%, mainly because of these complications. Twenty-seven patients delivered of 31 healthy children. There was no congenital anomaly. Mean birth weight was 2.640 +/- 645 g. In utero growth retardation occurred in 7 cases (23%). Pregnancy after renal transplantation is of good prognosis for both the mother and child but the course of pregnancy can be complicated by hypertension, preterm birth and growth retardation.
Ville
Y
Y
Service de Gynécologie-Obstétrique, Hôpital Antoine-Béclère, Clamart.
Fernandez
H
H
Edouard
D
D
Frydman
R
R
D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D001724:Birth Weight; D002585:Cesarean Section / Q000706:statistics & numerical data; D016572:Cyclosporine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology / Q000209:etiology; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000209:etiology; D016030:Kidney Transplantation / Q000276:immunology / Q000502:physiology; D007752:Obstetric Labor, Premature / Q000453:epidemiology / Q000209:etiology; D011241:Prednisone / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology* / Q000209:etiology; D011256:Pregnancy Outcome; D011379:Prognosis; D012307:Risk Factors
D016572:Cyclosporine; D001379:Azathioprine; D011241:Prednisone
La grossesse après transplantation rénale. A propos de 27 patientes et revue de la littérature.