[Antigen detection in the murine models of systemic candidiasis].
We compared two latex agglutination tests for serum candidal antigen in murine models of systemic infection and gastrointestinal colonization. In the intravascular-infection model, mannan detection test was positive at 2 hours after inoculation, but Cand-Tec was less sensitive than mannan detection test in this model. In the gastrointestinal colonization model followed by systemic infection in neutropenic mice, the mannan antigen test became positive after 3 weeks of colonization with increased number of Candida of the stool, and Cand-Tec became positive after 5 weeks in neutropenic mice.
Mitsutake
K
K
Second Department of Internal Medicine, School of Medicine, Nagasaki University.
Kohno
S
S
Matsuda
H
H
Yoshitomi
Y
Y
Miyazaki
Y
Y
Higashiyama
Y
Y
Tanaka
K
K
Iwamoto
M
M
Maesaki
S
S
Kaku
M
M
D000818:Animals; D000946:Antigens, Fungal / Q000032:analysis*; D002176:Candida albicans / Q000276:immunology; D002177:Candidiasis / Q000276:immunology*; D004195:Disease Models, Animal; D007841:Latex Fixation Tests; D008297:Male; D008351:Mannans / Q000097:blood; D051379:Mice; D008807:Mice, Inbred BALB C
D000946:Antigens, Fungal; D008351:Mannans