title: Inferior vena cava leiomyosarcoma.
abstract: Leiomyosarcoma of the inferior vena cava is a rare malignancy, and radical resection with negative margins remains the only hope for cure. In this report we cite four cases of this tumor treated at The University of Texas M.D. Anderson Cancer Center with particular emphasis on the use of preoperative chemotherapy. In our patients, preoperative chemotherapy did not adversely affect operative outcomes or survival. The potential benefits of preoperative chemotherapy include control of micrometastases, reduction in tumor size before resection, and in situ evaluation of tumor response to chemotherapy for postoperative adjuvant therapy.
authors.affiliation: Department of General Surgery, University of Texas M.D. Anderson Cancer Center, Houston 77030.
authors.forename: M L
authors.initials: ML
authors.lastname: Demers
authors.forename: S A
authors.initials: SA
authors.lastname: Curley
authors.forename: M M
authors.initials: MM
authors.lastname: Romsdahl
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D012983:Soft Tissue Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D014652:Vascular Diseases / Q000188:drug therapy / Q000401:mortality / Q000601:surgery; D014682:Vena Cava, Inferior