Prognostic role of flow cytometry in superficial bladder cancer.
Prognostic factors in superficial transitional cell carcinoma of the bladder were assessed with histopathological and flow cytometry analysis in a series of 61 patients operated transurethrally between 1988 and 1990. In particular, we evaluated the usefulness of flow cytometry in order to identify patients who require a more accurate clinical follow-up or a more aggressive therapy. A multivariate analysis was done in 61 cases, considering patient age and sex, stage, grade and number of lesions (unifocal or multifocal), post-TUR therapy (therapy or not), and DNA ploidy (diploid/aneuploid). DNA pattern and number of recurrences were determinant for selecting risk cases for progression.
Di Silverio
F
F
Department of Urology, University La Sapienza, Rome, Italy.
von Heland
M
M
De Berardinis
E
E
Izzi
R
R
Buscarini
M
M
De Vita
R
R
Forte
R
R
Seccareccia
F
F
Menotti
A
A
D002295:Carcinoma, Transitional Cell / Q000235:genetics / Q000473:pathology*; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D011003:Ploidies; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D001749:Urinary Bladder Neoplasms / Q000235:genetics / Q000473:pathology*
D004273:DNA, Neoplasm