title: [Natural modulators of the function of the amine oxidase system in the body].
abstract: In cerebrospinal fluid (CSF) obtained from patients with chronic alcoholism natural modulators of monoamine oxidase (MAO) activity, containing in human mitochondrial and microsomal fractions or in rat brain mitochondria, have been found. These modulators, which were previously unknown, did not affect the activity of partially purified diamine oxidase from human placenta with 14C-putrescine as a substrate. The MAO modulators from CSF were thermostable (during 3 min at 100 degrees), penetrated through dialysing membrane thus differing from high molecular modulators of MAO previously described. In the system containing membrane bound MAO from human placenta, where the MAO-A is predominating, the modulators studied mostly inhibited deamination of 14C-serotonin. However, in the system containing membrane bound MAO from rat brain with prevalence of the MAO-B, the modulators from human CSF caused either inhibition or stimulation of oxidative deamination of 14C-serotonin or 14C-beta-phenylethylamine used as substrates. The modulators studied were not similar to tribulin (isatin) or quinolinic acid in their effects on catalytic properties of the amine oxidases investigated.
authors.forename: V Z
authors.initials: VZ
authors.lastname: Gorkin
authors.forename: L V
authors.initials: LV
authors.lastname: Gubskiĭ
authors.forename: N S
authors.initials: NS
authors.lastname: Kamyshanskaia
authors.forename: A Z
authors.initials: AZ
authors.lastname: Kirkel'
authors.forename: L N
authors.initials: LN
authors.lastname: Ovchinnikova
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000201:enzymology*; D000586:Amination; D000818:Animals; D005260:Female; D006801:Humans; D008297:Male; D008861:Microsomes / Q000201:enzymology; D008875:Middle Aged; D008928:Mitochondria / Q000201:enzymology; D008995:Monoamine Oxidase / Q000134:cerebrospinal fluid*; D010920:Placenta / Q000201:enzymology; D011700:Putrescine / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013379:Substrate Specificity
chemical_list: D012701:Serotonin; D008995:Monoamine Oxidase; D011700:Putrescine
vernacular_title: O prirodnykh moduliatorakh funktsiĭ sistemy aminoksidaz v organizme.