title: Intellectual deficits in first-episode schizophrenia: evidence for progressive deterioration.
abstract: The developmental processes leading to neuropsychological deficits in schizophrenia are poorly understood. Both early developmental defects and subsequent deterioration may occur. Intelligence test profiles are often used to estimate premorbid ability and deterioration from prior levels of functioning. These characteristics were assessed in samples of first-episode (n = 51) and chronic (n = 50) schizophrenic patients. Although the groups showed few differences on tests to estimate premorbid intellectual ability, the chronic group performed worse on measures considered sensitive to deterioration. Dextral (right-handed) patients tended to have better performance; this effect was marked in the first-episode sample, especially on verbal tests. Male patients showed more evidence of deterioration than female patients. Subgroups differing in the time course of premorbid social dysfunction also differed in intelligence test profiles, suggesting that estimates of social and cognitive deterioration may have concurrent validity. The results support the hypothesis that patients differ in the course of cognitive decline and suggest that deterioration of function may follow the onset of overt psychosis in some patients. Prospective longitudinal studies of first-episode schizophrenic patients could directly test this hypothesis.
authors.affiliation: Long Island Jewish-Hillside Medical Center, Glen Oaks, NY 11004.
authors.forename: R M
authors.initials: RM
authors.lastname: Bilder
authors.forename: L
authors.initials: L
authors.lastname: Lipschutz-Broch
authors.forename: G
authors.initials: G
authors.lastname: Reiter
authors.forename: S H
authors.initials: SH
authors.lastname: Geisler
authors.forename: D I
authors.initials: DI
authors.lastname: Mayerhoff
authors.forename: J A
authors.initials: JA
authors.lastname: Lieberman
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007360:Intelligence / Q000502:physiology*; D007361:Intelligence Tests; D008297:Male; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012737:Sex Factors; D012917:Social Adjustment