B700 antigen as a component of an antimelanoma vaccine: formalinized extracellular antigens.
Formalin fixation has enjoyed widespread use in the preparation of antibacterial and other vaccines, but rather less use in antitumor vaccines. Previous studies from our laboratories have demonstrated the efficacy of antimelanoma vaccines in mice, produced from formalinized antigens shed by cultured melanoma cells. In this study, we provide evidence that the immunodominant component of that vaccine is the well-characterized B700 melanoma antigen.
Shrayer
D
D
Department of Experimental Pathology, Roger Williams Medical Center, Brown University, Providence 02908.
Gersten
D M
DM
Koness
J
J
Maizel
A
A
Wanebo
H
H
Hearing
V J
VJ
D000818:Animals; D000951:Antigens, Neoplasm; D017077:Culture Media, Conditioned / Q000737:chemistry; D005260:Female; D005557:Formaldehyde; D008545:Melanoma / Q000276:immunology*; D058950:Melanoma-Specific Antigens; D051379:Mice; D008810:Mice, Inbred C57BL; D009363:Neoplasm Proteins; D013047:Specific Pathogen-Free Organisms; D014407:Tumor Cells, Cultured; D014612:Vaccines
D000951:Antigens, Neoplasm; D017077:Culture Media, Conditioned; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins; D014612:Vaccines; D005557:Formaldehyde