Butyrolactols A and B, new antifungal antibiotics. Taxonomy, isolation, physico-chemical properties, structure and biological activity.
New antifungal antibiotics, butyrolactols A and B, have been isolated from the culture broth of Streptomyces rochei S785-16. They are novel type of molecules containing a common 2,3-dihydroxybutyrolactone nucleus substituted with a different long hydroxyalkyl side chain. Butyrolactol A showed good antifungal activity against Aspergillus fumigatus and Trichophyton mentagrophytes, and moderately inhibited the growth of yeasts.
Kotake
C
C
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
Yamasaki
T
T
Moriyama
T
T
Shinoda
M
M
Komiyama
N
N
Furumai
T
T
Konishi
M
M
Oki
T
T
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000107:Acetylation; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006868:Hydrolysis; D006900:Hydroxylation; D008826:Microbial Sensitivity Tests; D013302:Streptomyces / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; C077634:butyrolactol A; C077635:butyrolactol B; D015107:4-Butyrolactone