title: [An optimal method of pharmacological prevention of tuberculosis among adolescents].
abstract: The paper presents the findings of a comparative study of the efficacy of chemoprophylaxis which was conducted by the everyday (1 course) and intermittent (2 courses) method in adolescents aged 12-17 years, depending on the presence of aggravating factors. Examination covered 150 adolescents from the VI registration group. Following chemoprophylaxis there was a drop in sensitivity to tuberculin in 95.5 +/- 0.8% of group 1 (main) and in 78.5 +/- 1.1% of group 2 cases during which a medium size of an infiltrate in group 1 reduced by 2.8 mm more than that in group 2 (p less than 0.001). After the end of an observation period, 92.4 +/- 0.8% of subjects of group 1 and 79.4 +/- 0.5% of subjects of group 2 were struck off the register from the VIA registration group; the respective figures for the VIB registration group were 73.2 +/- 0.2% and 58.6 +/- 3%. The epidemiologic and economic effect of chemoprophylaxis conducted by 2 courses was 2 and 1.5 times higher than that in the traditional method.
authors.forename: K G
authors.initials: KG
authors.lastname: Ganiev
authors.forename: O V
authors.initials: OV
authors.lastname: Butyl'chenko
mesh_terms: D000293:Adolescent; D000295:Adolescent Medicine / Q000379:methods*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage*; D008297:Male; D014374:Tuberculin Test; D014397:Tuberculosis, Pulmonary / Q000276:immunology / Q000517:prevention & control*; D014610:Uzbekistan
chemical_list: D007538:Isoniazid
vernacular_title: Optimizatsiia khimioprofilaktiki tuberkuleza u podrostkov.