Fluoride and calcium content of enamel organ, muscle, liver and plasma in rats.
Nine-day-old rats were given oral fluoride doses (0.5 micrograms F/g body weight). Plasma, enamel organ, muscle and liver samples were collected from nondosed pups (baseline) and 15, 30, 60 and 120 min after the dose. Samples were assayed for fluoride and calcium concentrations. Adult rats were given 20 ppm F water for 6 weeks, and the same tissues were sampled and assayed for fluoride concentrations only. In the first phase of the study, enamel organ had significantly higher fluoride and calcium content than liver and muscle. In adult rats the fluoride content of enamel organ was again significantly higher than for liver and muscle.
Bawden
J W
JW
Department of Pediatric Dentistry, University of North Carolina, Chapel Hill 27599-7455.
Deaton
T G
TG
Crawford
B P
BP
D000284:Administration, Oral; D000375:Aging; D000818:Animals; D000833:Animals, Suckling; D002118:Calcium / Q000032:analysis* / Q000097:blood*; D004658:Enamel Organ / Q000737:chemistry*; D005260:Female; D005459:Fluorides / Q000008:administration & dosage / Q000032:analysis* / Q000097:blood*; D008099:Liver / Q000737:chemistry*; D009132:Muscles / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D005459:Fluorides; D002118:Calcium