Neurological damage mediated by cytokines.
Our results suggest that CKs, in particular Interleukin-1 and Tumor Necrosis Factor (TNF)-alpha, are involved in the pathogenesis of some neurological disorders and HIV infection. Infact, we observed an exaggerated spontaneous release of TNF-alpha in patients with migraine without aura. Furthermore, in a broad spectrum of patients with HIV-infection we have also found increased amounts of serum TNF-alfa and IL-1. Interestingly, a strict correlation between plasma lipopolysaccharide (LPS) and IL-1 or TNF-alpha levels seems to exist in both group of patients, thus indicating that LPS could account for the production of CKs in the course of the above diseases.
Munno
I
I
Cattedra di Immunologia, Università di Bari, Italy.
Pellegrino
N M
NM
Marcuccio
C
C
Conrotto
L
L
Jirillo
E
E
Covelli
V
V
D015526:AIDS Dementia Complex / Q000503:physiopathology; D016207:Cytokines / Q000502:physiology*; D004731:Endotoxins / Q000097:blood; D015658:HIV Infections / Q000150:complications / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D007375:Interleukin-1 / Q000097:blood / Q000502:physiology; D008881:Migraine Disorders / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology; D009422:Nervous System Diseases / Q000503:physiopathology*; D009894:Opportunistic Infections / Q000150:complications / Q000503:physiopathology; D011994:Recombinant Proteins / Q000009:adverse effects; D014409:Tumor Necrosis Factor-alpha / Q000009:adverse effects / Q000502:physiology
D016207:Cytokines; D004731:Endotoxins; D007375:Interleukin-1; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha