[Kinetics of pharmacologic effects of radix Aconiti Lateralis Preparata and sini decoction].
In the study of analgesic action of Radix Aconiti Lateralis Preparata and Sini Decoction hot-plate method was used and the time-effect relationship was determined. The biological half-lives were 11.05 h and 6.84 h respectively. In the study of the effect on inflammation induced by egg white in the ankle joints of rats, the method of complement ED50 was used. The residual rates of the dosages after an interval of 6 hours were 0.60 and 0.69, and the biological half-lives were 8.11 h and 11.35 h respectively.
Zhou
J
J
Shanghai College of Traditional Chinese Medicine.
Chen
C
C
Su
J
J
Yin
H
H
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy; D051379:Mice; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D012684:Sensory Thresholds / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal