title: Comparison of the nonionic contrast agents, iopromide and iotrolan, for positive-contrast arthrography of the scapulohumeral joint in dogs.
abstract: Arthrographic quality and synovial inflammatory response were examined to compare the use of iopromide with that of iotrolan for arthrography of the scapulohumeral joint in 6 dogs. Radiographs obtained 1 and 3 minutes after injection of either nonionic compound were of similar quality, but radiographs obtained 5 minutes after injection of iotrolan were significantly (P less than 0.05) better than those obtained after injection of iopromide. Results of analysis of synovial fluid samples obtained at 1, 3, 7, and 14 days after injection of contrast media were not significantly different between the 2 groups. Histologic examination of synovium and articular cartilage 2 weeks after injection of iopromide or iotrolan revealed minimal inflammatory response for both contrast agents. Injection of iopromide and iotrolan into the scapulohumeral joints of dogs had less effect on synovial fluid than that reported after injection of ionic compounds.
authors.affiliation: Department of Radiology, State University of Ghent, Belgium.
authors.forename: H
authors.initials: H
authors.lastname: van Bree
authors.forename: B
authors.initials: B
authors.lastname: Van Rijssen
authors.forename: M
authors.initials: M
authors.lastname: Tshamala
authors.forename: T
authors.initials: T
authors.lastname: Maenhout
mesh_terms: D000818:Animals; D001175:Arthrography / Q000592:standards / Q000662:veterinary*; D002358:Cartilage, Articular / Q000187:drug effects; D003287:Contrast Media / Q000009:adverse effects; D004285:Dogs / Q000033:anatomy & histology*; D005260:Female; D006820:Hyaluronic Acid / Q000032:analysis; D007472:Iohexol / Q000009:adverse effects / Q000031:analogs & derivatives*; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D007958:Leukocyte Count / Q000662:veterinary; D008297:Male; D011506:Proteins / Q000032:analysis; D012785:Shoulder Joint / Q000000981:diagnostic imaging*; D013582:Synovial Fluid / Q000737:chemistry / Q000166:cytology; D013583:Synovial Membrane / Q000187:drug effects; D014283:Triiodobenzoic Acids / Q000009:adverse effects; D014783:Viscosity
chemical_list: D003287:Contrast Media; D011506:Proteins; D014283:Triiodobenzoic Acids; C033300:iotrolan; D007472:Iohexol; C038192:iopromide; D006820:Hyaluronic Acid; D007770:L-Lactate Dehydrogenase