[Antipyrine metabolism and rat liver ultrastructure in single and combined action of trichlorodiphenyl and dioctyl phthalate].
As shown by animal experiments, low-dose trichlorodophenyl and dioctyl phthalate induce microsomal cytochrome P-450-dependent enzymes and ultrastructural changes in hepatocytes. This evidences hepatotoxicity of the compounds.
Gorenkov
R V
RV
Liubchenko
P N
PN
Bendikov
E A
EA
Potapova
V B
VB
Petrakov
A V
AV
Ul'ianova
V V
VV
D000818:Animals; D000983:Antipyrine / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004051:Diethylhexyl Phthalate / Q000008:administration & dosage / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D008930:Mitochondria, Liver / Q000187:drug effects / Q000648:ultrastructure; D011078:Polychlorinated Biphenyls / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats
D003577:Cytochrome P-450 Enzyme System; D004051:Diethylhexyl Phthalate; D011078:Polychlorinated Biphenyls; D000983:Antipyrine
Metabolizm antipirina i ul'trastruktura pecheni krys pri izolirovannom i sochetannom deĭstvii trikhlordifenila i dioktilftalata.