title: An electrophysiological study of D2 dopaminergic actions in normal human retina: a tool in Parkinson's disease.
abstract: A peculiar deficit of electrophysiological retinal responses to pattern reversal grating stimuli has been reported in Parkinson's disease (PD) patients. A similar abnormality has been reproduced by means of non-selective dopaminergic antagonists in normal humans. Aim of this study was to verify, by means of a selective D2 antagonist (sulpiride) administered to normal subjects, whether a D2 blockade affects the visual electrophysiological performances with the same trend as observed in PD patients. Patterns electroretinogram (PERG) responses to 1 cycle per degree (c/d) of spatial frequency at 1 (transient) and 7.5 (steady state) Hz of temporal modulation of a square-wave grating pattern reversal have been recorded in 19 healthy volunteers before and after the administration of 100 mg i.m. of sulpiride. The data are consistent for the following conclusion: a selective D2 antagonist reduces steady state and delays transient retinal responses as expected for a PD mimicking agent.
authors.affiliation: Clinica Neurologica II Università di Roma Tor Vergata, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Stanzione
authors.forename: R
authors.initials: R
authors.lastname: Traversa
authors.forename: M
authors.initials: M
authors.lastname: Pierantozzi
authors.forename: R
authors.initials: R
authors.lastname: Semprini
authors.forename: M G
authors.initials: MG
authors.lastname: Marciani
authors.forename: G
authors.initials: G
authors.lastname: Bernardi
mesh_terms: D000328:Adult; D065127:Dopamine D2 Receptor Antagonists; D006801:Humans; D010300:Parkinson Disease / Q000503:physiopathology*; D017448:Receptors, Dopamine D2 / Q000502:physiology*; D012016:Reference Values; D012160:Retina / Q000187:drug effects / Q000502:physiology*; D013469:Sulpiride / Q000494:pharmacology*; D014786:Vision Disorders / Q000209:etiology*
chemical_list: D065127:Dopamine D2 Receptor Antagonists; D017448:Receptors, Dopamine D2; D013469:Sulpiride