title: Animal models for testing topical corticosteroid potency: a review and some suggested new approaches.
abstract: Animal models allow for testing the potency of topical corticosteroids by measuring their effects on induced conditions that are analogous to human skin disease. Animal models can examine the anti-inflammatory, anti-allergic, antiproliferative, and atrophogenic effects of topical corticosteroids. These test models as they are currently applied are relatively imprecise; however, innovations using newly available histologic, autoradiographic, and biochemical techniques have great potential for precisely quantitating the effects of corticosteroids in animal model systems.
authors.affiliation: Division of Dermatology, Saint Louis University School of Medicine, MO 63104.
authors.forename: N S
authors.initials: NS
authors.lastname: Penneys
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005938:Glucocorticoids; D012871:Skin Diseases / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids