title: The east gene of Drosophila melanogaster is expressed in the developing embryonic nervous system and is required for normal olfactory and gustatory responses of the adult.
abstract: Drosophila melanogaster larvae and adults respond to a wide range of chemosensory stimuli. We describe the genetics and developmental expression of the east gene, mutations which result in adult-specific chemosensory defects. The original isolate of east is semidominant for the behavioral phenotype. Several mutations have been generated, some of which are recessive lethals and others that are viable alleles that show a recessive, adult-specific, chemosensory defect. No larval chemosensory defects were observed. The east gene is expressed in the neurogenic region at the time of neuroblast segregation and in cells in the peripheral and central nervous system. Our results suggest that east+ expression in the nervous system is required for a normal adult chemosensory response and both increases and decreases in levels of the gene product result in a mutant phenotype.
authors.affiliation: Molecular Biology Unit, Tata Institute of Fundamental Research, Colaba, Bombay, India.
authors.forename: K
authors.initials: K
authors.lastname: VijayRaghavan
authors.forename: J
authors.initials: J
authors.lastname: Kaur
authors.forename: J
authors.initials: J
authors.lastname: Paranjape
authors.forename: V
authors.initials: V
authors.lastname: Rodrigues
mesh_terms: D000483:Alleles; D000818:Animals; D002490:Central Nervous System / Q000196:embryology; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics* / Q000502:physiology; D005786:Gene Expression Regulation; D009024:Morphogenesis