title: PEO enhancement of platelet deposition, fibrinogen deposition, and complement C3 activation.
abstract: Whereas it has been commonly thought that adding polyethylene oxide PEO to a surface would diminish the capacity of the surface to cause deposition of platelets and of fibrinogen, and to activate complement C3, we present data showing exactly the opposite. These unexpected results are obtained with low molecular weight (2000) PEO, and are not found with higher molecular weight (20,000) PEO.
authors.affiliation: Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge 02139.
authors.forename: E L
authors.initials: EL
authors.lastname: Chaikof
authors.forename: E W
authors.initials: EW
authors.lastname: Merrill
authors.forename: A D
authors.initials: AD
authors.lastname: Callow
authors.forename: R J
authors.initials: RJ
authors.lastname: Connolly
authors.forename: S L
authors.initials: SL
authors.lastname: Verdon
authors.forename: K
authors.initials: K
authors.lastname: Ramberg
mesh_terms: D000818:Animals; D003167:Complement Activation; D003176:Complement C3 / Q000502:physiology*; D005340:Fibrinogen / Q000502:physiology*; D008855:Microscopy, Electron, Scanning; D008970:Molecular Weight; D010215:Papio; D010973:Platelet Adhesiveness / Q000502:physiology*; D011092:Polyethylene Glycols / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D003176:Complement C3; D011092:Polyethylene Glycols; D005340:Fibrinogen