Co-exposure to gasoline vapor decreases benzene metabolism in Fischer-344 rats.
The metabolic interactions of benzene and gasoline vapor were investigated in male Fischer-344 rats. A closed chamber gas-uptake exposure system was used to obtain inhalation uptake curves for benzene alone and benzene in the presence of gasoline vapor. Exposure to benzene as a component of gasoline vapor resulted in a decrease of benzene metabolism. A physiologically based pharmacokinetic model of benzene metabolism was used to quantitatively determine the extent of the inhibitory effect of gasoline vapor on benzene metabolism. This observed inhibitory effect cannot be accounted for by the presence of toluene in gasoline vapor.
Travis
C C
CC
Risk Analysis Section, Oak Ridge National Laboratory, TN 37831-6109.
Fox
M T
MT
Simmons
W M
WM
Lyon
B F
BF
D000818:Animals; D001273:Atmosphere Exposure Chambers; D001554:Benzene / Q000378:metabolism* / Q000493:pharmacokinetics; D003198:Computer Simulation; D004347:Drug Interactions; D005742:Gasoline; D008297:Male; D008954:Models, Biological; D051381:Rats; D011916:Rats, Inbred F344
D005742:Gasoline; D001554:Benzene