[Experimental model of Parkinson disease: mechanisms and anatomo- pathological characteristics of MPTP neurotoxicity].
MPTP administration induces a fairly selective lesion of substantia nigra dopaminergic neurons both in animals and humans. This characteristic of MPTP has led to the best available model of Parkinson's disease and neuronal degenerations. MPTP toxicity is actually provoked by MPP+ which results after oxidation by MAO-B. Possible mechanism of action of MPP+ include: 1) Mitochondrial lesion. 2) Free radicals generation. 3) Trapping of MPP+ by highly melanized neurons. This article reviews the mechanisms of toxicity by MPTP and its neuropathological characteristics.
Herrero
M T
MT
Departamento de Neurología, Universidad de Navarra, Pamplona.
Luquín
M R
MR
Obeso
J A
JA
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000493:pharmacokinetics; D000818:Animals; D001711:Biotransformation; D004298:Dopamine / Q000378:metabolism; D005609:Free Radicals; D020267:MPTP Poisoning; D008251:Macaca; D008543:Melanins / Q000378:metabolism; D008928:Mitochondria / Q000187:drug effects / Q000473:pathology; D008995:Monoamine Oxidase / Q000378:metabolism; D009410:Nerve Degeneration; D010084:Oxidation-Reduction; D010302:Parkinson Disease, Secondary / Q000209:etiology / Q000473:pathology*; D013378:Substantia Nigra / Q000187:drug effects* / Q000473:pathology
D005609:Free Radicals; D008543:Melanins; C014121:neuromelanin; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D008995:Monoamine Oxidase; D004298:Dopamine
Modelo experimental de enfermedad de Parkinson: mecanismos y características anatomopatológicas de la neurotoxicidad por MPTP.