Dynamics of oral intake resumption after general anesthesia and operation in rats.
The influence of general anesthesia and operation on dynamics of postoperative food intake resumption was investigated in eight rats. A laparotomy was performed on each rat under anesthesia induced by intraperitoneally injected chloral hydrate. Spontaneous food intake and feeding indexes were continuously measured using an Automated Computerized Rat Eater Meter (ACREM) before and after operation. Although spontaneous food intake and all feeding indexes were depressed immediately following anesthesia and operation, each feeding index was depressed to a greater degree during the dark vs. the light cycle. Initially, rats fully capable of eating ate fewer, smaller, and shorter meals. The return to normal of each feeding index differed temporally. Thus, although meal number normalized by the third postoperative day, meal size by the sixth postoperative day, and meal duration by the fourth postoperative day, normalization of meal number during the light cycle occurred sooner than during the dark cycle, while the converse occurred with meal size and meal duration.
Meguid
M M
MM
Department of Surgery, University Hospital, SUNY Health Science Center, Syracuse 13210.
Yang
Z J
ZJ
Ratto
C
C
Meguid
R A
RA
Hitch
D C
DC
Kubota
A
A
Campos
A C
AC
D000768:Anesthesia, General; D000818:Animals; D002697:Chloral Hydrate; D002940:Circadian Rhythm / Q000502:physiology; D004435:Eating / Q000502:physiology*; D005518:Food Preferences / Q000523:psychology; D008297:Male; D010507:Periodicity; D011184:Postoperative Period; D051381:Rats; D011916:Rats, Inbred F344
D002697:Chloral Hydrate