The effect of 3-amino-1,2,4-triazole on voluntary ethanol consumption: evidence for brain catalase involvement in the mechanism of action.
The effects of the catalase inhibitor, 3-amino-1,2,4-triazole (AT), on maintenance of voluntary consumption of ethanol was tested in male Long-Evans rats. AT produced a dose-dependent reduction in ethanol intake but did not affect total fluid consumption. AT also produced a dose-dependent inhibition of brain catalase lasting throughout the drinking period. These results suggest a role for brain catalase in determining the level of ethanol intake in rats.
Aragon
C M
CM
Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, Canada.
Amit
Z
Z
D000428:Alcohol Drinking; D000640:Amitrole / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology / Q000502:physiology*; D002374:Catalase / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004327:Drinking Behavior / Q000187:drug effects*; D008297:Male; D051381:Rats
D002374:Catalase; D000640:Amitrole