title: Measurement of total bodywater volume with deuterated water in newborn infants.
abstract: D2O and H2(18)O are often used as tracers for the determination of total body water (TBW). For newborn infants, the commonly used noninvasive method has not been validated. In this study TBW was calculated from D2O concentrations in blood and compared with TBW calculated from D2O concentrations in urine. TBW calculated from all urine portions voided at least 6 h after D2O administration on average was 1.0% lower. TBW calculated from only three urine portions voided 6, 12, and 24 h after D2O administration was 0.6% (mean) lower compared to TBW calculated from D2O concentrations in blood. This study indicates that the noninvasive method to measure TBW can be considered a reliable method when used in newborn infants.
authors.affiliation: Department of Pediatrics, University Hospital Groningen, The Netherlands.
authors.forename: R
authors.initials: R
authors.lastname: Baarsma
authors.forename: P
authors.initials: P
authors.lastname: Hof
authors.forename: W G
authors.initials: WG
authors.lastname: Zijlstra
authors.forename: J P
authors.initials: JP
authors.lastname: Zock
authors.forename: A
authors.initials: A
authors.lastname: Okken
mesh_terms: D001834:Body Water / Q000378:metabolism*; D003903:Deuterium; D006801:Humans; D007231:Infant, Newborn / Q000378:metabolism* / Q000652:urine; D008722:Methods; D009994:Osmolar Concentration
chemical_list: D003903:Deuterium