B-cell lymphoma presenting as a midfacial necrotizing lesion.
A case of midfacial necrotizing lesion (midline nonhealing granuloma) is reported. Paraffin- and frozen-section immunocytochemistry suggested a tumor of B-cell lineage and was confirmed by Southern blot analysis that disclosed an immunoglobulin heavy chain gene rearrangement with no evidence of T-cell receptor genetic aberration. The tumor was of B-cell lineage despite the tumor site and the angiocentric pattern, which are typically seen with peripheral T cell lymphoma with this presentation.
Maxymiw
W G
WG
Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Canada.
Patterson
B J
BJ
Wood
R E
RE
Meharchand
J M
JM
Munro
A J
AJ
G'orska-Flipot
I
I
D000368:Aged; D015139:Blotting, Southern; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005260:Female; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D006103:Granuloma, Lethal Midline / Q000175:diagnosis*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D008444:Maxillary Sinus Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D009060:Mouth Floor; D010157:Palatal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D012888:Skull Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy