title: Thyroid papillary adenocarcinoma in a woman with Peutz-Jeghers syndrome.
abstract: We present a rare case of Peutz-Jeghers(P-J) syndrome in a 29-year-old woman who developed adenocarcinoma of the thyroid and polyps in the gastrointestinal tract. Polyps removed from the stomach, colon and ileum showed features typical of hamartomas. Histological examination indicated that the tumor resected from the right lobe of the thyroid was a papillary adenocarcinoma. This appears to be the first precise report of a P-J syndrome associated with thyroid carcinoma. This case adds an example of predisposition of P-J syndrome to extra-intestinal malignancy and indicates the importance of long-term observation of malignancy.
authors.affiliation: Department of Internal Medicine, Anjo Kosei Hospital, Aichi, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
authors.forename: H
authors.initials: H
authors.lastname: Hoshino
authors.forename: T
authors.initials: T
authors.lastname: Onizuka
authors.forename: M
authors.initials: M
authors.lastname: Ichikawa
authors.forename: A
authors.initials: A
authors.lastname: Kawakubo
authors.forename: S
authors.initials: S
authors.lastname: Hayakawa
mesh_terms: D000231:Adenocarcinoma, Papillary; D000328:Adult; D005260:Female; D006222:Hamartoma; D006801:Humans; D009378:Neoplasms, Multiple Primary; D010580:Peutz-Jeghers Syndrome; D013964:Thyroid Neoplasms