An extended view of nuclear lamin structure, function, and dynamics.
Molecularly-based studies of nuclear lamins have progressed at a rapid rate in the last decade. However, we still have no answer to the most important question: what are the functions of lamins? In this review we describe recent experiments which challenge traditional views of lamin function and structure. These surprising results indicate that much lamin functionality remains to be discovered, and that more global approaches to lamin structure and function are especially appropriate at this time.
Paddy
M R
MR
Howard Hughes Medical Institute, University of California, San Francisco 94143-0554.
Agard
D A
DA
Sedat
J W
JW
D000818:Animals; D016203:CDC2 Protein Kinase / Q000378:metabolism; D004331:Drosophila melanogaster / Q000033:anatomy & histology / Q000196:embryology; D007381:Intermediate Filament Proteins / Q000502:physiology*; D007399:Interphase; D034882:Lamins; D008938:Mitosis; D009685:Nuclear Envelope / Q000648:ultrastructure; D015530:Nuclear Matrix / Q000648:ultrastructure*; D009687:Nuclear Proteins / Q000502:physiology*; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational
D007381:Intermediate Filament Proteins; D034882:Lamins; D009687:Nuclear Proteins; D016203:CDC2 Protein Kinase