The importance of cell physiology to the performance of animal cell bioreactors.
This report has pointed out the following: (1) the new animal cell products that will be produced commercially will have large dollar markets and will, together with cost containment and competitive pressures, place a greater emphasis on the reduction of the cost of production through the selection of appropriate culture technology; (2) the benefits to be gained by working with basic biological processes in animal cell culture that will increase cell density, cell productivity, and product quality; (3) the need to work with reactor technologies that can affect the basic biology of the cell in these positive ways; (4) it appears worthwhile to explore immobilized, high cell density culture technologies as a possible means to achieve the objectives by affecting the basic regulation of the cell through fundamental cell/cell environment biological processes.
Runstadler
P W
PW
Verax Corporation, Lebanon, New Hampshire 03766.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis*; D001688:Biological Products / Q000096:biosynthesis*; D001709:Biotechnology / Q000191:economics / Q000379:methods / Q000592:standards; D002468:Cell Physiological Phenomena; D002477:Cells / Q000166:cytology; D046508:Culture Techniques / Q000191:economics / Q000379:methods* / Q000592:standards; D008322:Mammals; D011994:Recombinant Proteins / Q000096:biosynthesis*
D000911:Antibodies, Monoclonal; D001688:Biological Products; D011994:Recombinant Proteins