title: Chronic lymphocytic leukaemia presenting as renal failure with lymphocytic infiltration of the kidneys.
abstract: A case of renal failure is reported in a 60-yr-old male as the first clinical manifestation of chronic lymphocytic leukaemia (CLL). It appeared to be due to a massive interstitial infiltration of both kidneys by small lymphocytes. Combination chemotherapy consisting of monthly courses of cyclophosphamide, vincristine and prednisone (COP), resulted in a rapid improvement of the renal function and in an apparent haematological and clinical remission of the CLL. After six courses, the COP therapy was stopped and replaced by a maintenance treatment with oral chlorambucil. During follow up, now lasting more than 3 years, no deterioration of renal function has been noted.
authors.affiliation: Department of Internal Medicine, Hospital Enschede, Netherlands.
authors.forename: V
authors.initials: V
authors.lastname: Haraldsdóttir
authors.forename: C
authors.initials: C
authors.lastname: Haanen
authors.forename: J G
authors.initials: JG
authors.lastname: Jordans
mesh_terms: D001706:Biopsy; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007676:Kidney Failure, Chronic / Q000209:etiology* / Q000473:pathology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged