[A study of the effect of fish oils on the risk factors of cardiovascular and cerebrovascular diseases].
In this study 22 normotensive (NT) and 12 essential hypertensive (EHT) subjects were included to test the possibility that fish oils might influence the blood pressure, plasma lipids and fibrinogen as well as the erythrocytic membrane lipid composition and pump activity. Each EHT subject was given capsules containing fish oils (6 g/d) for 18 days. At the end of the study, SBP fell (P < 0.05) and plasma fibrinogen level decreased (P < 0.05), while DBP, TG, TC, and HDL-C showed no significant change. The fatty acid composition of erythrocyte phosphatidyl ethanolamine (PE) and phosphatidyl choline (PC) showed the following changes: in PE, C22:6, C20:5 increased (P < 0.05; P < 0.01), CI18:1 decreased (P < 0.01); in PC C22:6, C22:4 increased (P < 0.05; P < 0.01). The activity of Na+, Ca2+ max, CaM-stimulated Ca2+ pumps increased (P < 0.05; P < 0.01; P < 0.01). As compared to NT, EHT subjects had higher C20:4 in both PE (P < 0.05) and PC (P < 0.01) and lower C18:2 in PC. It is also shown in this study that EHT subjects have higher C20:4 in both PE (P < 0.05) and PC (P < 0.01) and lower C18:2 in PC as compared to NT ones.
Wang
G L
GL
Shanghai Institute of Hypertension.
Zhao
G S
GS
Song
D J
DJ
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D002561:Cerebrovascular Disorders / Q000517:prevention & control; D004910:Erythrocyte Membrane / Q000737:chemistry; D005395:Fish Oils / Q000494:pharmacology*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D005395:Fish Oils