Efficacy of norfloxacin for shigellosis: a double-blind randomised clinical trial.
In a double-blind, randomised, clinical trial on 122 adults with acute Shigella dysentery, 60 patients were treated with norfloxacin and 62 with nalidixic acid. Of these, 32 patients in the norfloxacin group and 28 patients in the nalidixic acid group had Shigella in their stool. Patients of the two treatment groups were clinically comparable on admission. No significant differences in clinical responses were observed in the two groups among the Shigella-positive cases, Shigella-negative cases and among the total cases. All isolates of Shigella were susceptible to norfloxacin, whereas 13.8% of the strains were resistant to nalidixic acid.
Bhattacharya
M K
MK
Department of Clinical Medicine, National Institute of Cholera and Enteric Diseases, Beliaghata, Calcutta, India.
Nair
G B
GB
Sen
D
D
Paul
M
M
Debnath
A
A
Nag
A
A
Dutta
D
D
Dutta
P
P
Pal
S C
SC
Bhattacharya
S K
SK
D000328:Adult; D004311:Double-Blind Method; D004405:Dysentery, Bacillary / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009268:Nalidixic Acid / Q000494:pharmacology / Q000627:therapeutic use; D009643:Norfloxacin / Q000494:pharmacology / Q000627:therapeutic use*; D012760:Shigella / Q000187:drug effects
D009268:Nalidixic Acid; D009643:Norfloxacin