The effect of endogenous nitric oxide on neurogenic plasma exudation in guinea-pig airways.
We studied the effect of endogenous nitric oxide (NO) on vagally induced plasma exudation into guinea-pig trachea and main bronchi using 125I-albumin as a plasma marker. NG-Nitro-L-arginine methyl ester (L-NAME, 1-10 mg/kg) dose dependently inhibited neurogenic plasma exudation. Intravenous phenylephrine which simulated the vasopressor effect as L-NAME (10 mg/kg) was without effect. The effect of L-NAME (5 mg/kg) was reversed by L-arginine (50 mg/kg). These results suggest that endogenous NO may contribute to neurogenic inflammation in the airways.
Kuo
H P
HP
Department of Thoracic Medicine, National Heart and Lung Institute, London, UK.
Liu
S
S
Barnes
P J
PJ
D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D001980:Bronchi / Q000378:metabolism*; D004558:Electric Stimulation; D006168:Guinea Pigs; D008297:Male; D019331:NG-Nitroarginine Methyl Ester; D009569:Nitric Oxide / Q000378:metabolism*; D010949:Plasma / Q000378:metabolism*; D014132:Trachea / Q000378:metabolism*; D014630:Vagus Nerve / Q000502:physiology*
D009569:Nitric Oxide; D001120:Arginine; D019331:NG-Nitroarginine Methyl Ester