[Effects of neurotropin on seizure activity in picrotoxin kindling].
It is shown that both intracerebral and intraperitoneal neurotropin administration resulted in a decrease of seizure susceptibility of preliminary picrotoxin--kindled rats. On the other hand, neurotropin did not change the course of kindling development. Under conditions of acute picrotoxin--induced seizures it was observed that preliminary cycloheximide (protein-synthesis blocker) administration abolished anticonvulsant properties of neurotropin. It is concluded that anticonvulsant effects of neurotropin are realized via modulation of endogenous peptides synthesis and, in particular, cerulein.
Shandra
A A
AA
Godlevskiĭ
L S
LS
Mazarati
A M
AM
Vast'ianov
R S
RS
D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology*; D002108:Ceruletide / Q000096:biosynthesis; D003513:Cycloheximide / Q000494:pharmacology; D004569:Electroencephalography; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D010852:Picrotoxin; D011134:Polysaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000503:physiopathology / Q000517:prevention & control*
D000927:Anticonvulsants; D002108:Ceruletide; D003513:Cycloheximide; D010852:Picrotoxin; D011134:Polysaccharides; C010491:neurotropin
Vliianie neĭrotropina na sudorozhnuiu aktivnost' pri pikrotoksinovom kindlinge.