Pseudodiploid karyotypes in adenosquamous carcinomas of the lung.
Pseudodiploid karyotypes with clonal structural rearrangements were observed in short-term cultures from two adenosquamous carcinomas (ASC) of the lung, a tumor type hitherto virtually uncharacterized cytogenetically. The karyotypes were 46,XX,der(1)t(1;14)(q44;q22),add(9)(q34) in the first tumor and 46,XX,i(17)(q10) in the second tumor. We suggest that ASC of the lung differ from other lung cancers by having pseudodiploid instead of massively aneuploid tumor stemlines.
Johansson
M
M
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Jin
Y
Y
Heim
S
S
Mandahl
N
N
Hambraeus
G
G
Johansson
L
L
Mitelman
F
F
D000782:Aneuploidy; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D004171:Diploidy; D005260:Female; D006801:Humans; D007621:Karyotyping; D008175:Lung Neoplasms / Q000235:genetics*; D008875:Middle Aged