title: Anaplastic thyroid carcinoma with prominent cardiac metastasis, accompanied by a marked leukocytosis with a neutrophilia and high GM-CSF level in serum.
abstract: Cardiac metastasis of thyroid carcinoma is extremely rare. We treated a case of anaplastic thyroid carcinoma with prominent cardiac metastasis. The 61-year-old male was admitted because of high fever. Investigations revealed a cardiac mass and anaplastic thyroid carcinoma. Resection of the cardiac mass revealed that it was metastasis from the thyroid carcinoma. After 4 months, he died in spite of intensive therapy. Marked leukocytosis was observed during the clinical course, and a concomitant increase of granulocyte macrophage-colony stimulating factor (GM-CSF) level was demonstrated in the sera. It was suggested that the high GM-CSF level in serum contributed to leukocytosis.
authors.affiliation: Department of Internal Medicine, Kurashiki Central Hospital, Okayama, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Murabe
authors.forename: T
authors.initials: T
authors.lastname: Akamizu
authors.forename: A
authors.initials: A
authors.lastname: Kubota
authors.forename: S
authors.initials: S
authors.lastname: Kusaka
mesh_terms: D002277:Carcinoma / Q000556:secondary; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood; D006338:Heart Neoplasms / Q000556:secondary*; D006801:Humans; D007964:Leukocytosis / Q000097:blood; D008297:Male; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000473:pathology*
chemical_list: D016178:Granulocyte-Macrophage Colony-Stimulating Factor