[Effects of Kamikihi-To on autonomic imbalances in SART-stressed (repeated cold-stressed) mice].
The effects of Kamikihi-To (KMK), a traditional Chinese medicine, on autonomic imbalances were evaluated in SART-stressed (repeated cold-stressed) mice. These animals exhibited decreases in pain threshold and contraction of duodenum by acetylcholine, and they showed changes in their electrocardiogram and hematological parameters. All symptoms are thought to be caused by dysautonomia. KMK in dosages of 0.5 and 1.0 g/kg were administered to mice once a day for 8 consecutive days. SART stress was induced from the second day. KMK prevented the decrease in the pain threshold and contraction of the duodenum, although it had no effect on the electrocardiographic or hematological changes. KMK had no similar effect on unstressed mice. This data suggests that KMK might be useful for the treatment of clinical autonomic imbalances.
Matsuda
R
R
Traditional Chinese Medicine Research Laboratories, Kanebo, Ltd., Osaka, Japan.
Nishizawa
K
K
Inoue
O
O
Saito
Y
Y
Suzuki
A
A
Hata
T
T
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001342:Autonomic Nervous System Diseases / Q000188:drug therapy* / Q000503:physiopathology; D003080:Cold Temperature; D004056:Differential Threshold; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004386:Duodenum / Q000187:drug effects; D004562:Electrocardiography; D006403:Hematologic Tests; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010146:Pain; D013312:Stress, Physiological
D004365:Drugs, Chinese Herbal; D000109:Acetylcholine