MRI and SPECT findings in amyotrophic lateral sclerosis. Demonstration of upper motor neurone involvement by clinical neuroimaging.
MRI was performed in 21 patients and single photon emission computed tomography (SPECT) with N-isopropyl-p-123I iodoamphetamine in 16 patients, to visualize upper motor neurone lesions in amyotrophic lateral sclerosis. T2-weighted MRI revealed high signal along the course of the pyramidal tract in the internal capsule and cerebral peduncle in 4 of 21 patients. SPECT images were normal in 4 patients, but uptake was reduced in the cerebral cortex that includes the motor area in 11.
Udaka
F
F
Department of Neurology, Sumitomo Hospital, Osaka, Japan.
Sawada
H
H
Seriu
N
N
Shindou
K
K
Nishitani
N
N
Kameyama
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000662:Amphetamines; D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis* / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000473:pathology; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008279:Magnetic Resonance Imaging; D008297:Male; D008636:Mesencephalon / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D009044:Motor Cortex / Q000000981:diagnostic imaging / Q000473:pathology; D009046:Motor Neurons / Q000000981:diagnostic imaging* / Q000473:pathology*; D009413:Nerve Fibers, Myelinated / Q000000981:diagnostic imaging / Q000473:pathology; D011712:Pyramidal Tracts / Q000000981:diagnostic imaging / Q000473:pathology; D012026:Reflex, Stretch / Q000502:physiology; D015899:Tomography, Emission-Computed, Single-Photon; D014855:Wallerian Degeneration
D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine