Cerebrospinal fluid endothelin-1 in Alzheimer's disease and senile dementia of Alzheimer type.
We have measured the endothelin-1 concentrations in the cerebrospinal fluid samples from 5 patients with Alzheimer's disease (AD), 6 patients with senile dementia of Alzheimer type (SDAT) and 7 patients with other diseases without dementia (disease control: DC). The cerebrospinal fluid endothelin-1 level was significantly lower in AD than in DC. No correlation was observed between cerebrospinal fluid endothelin-1 concentration and any other factors such as age, duration from onset, systolic blood pressure, cerebrospinal fluid protein level or plasma endothelin-1 concentration in AD or SDAT. These results suggest a possible alteration of the endothelin-1 system in the central nervous system in Alzheimer's disease.
Yoshizawa
T
T
Department of Neurology, University of Tsukuba, Japan.
Iwamoto
H
H
Mizusawa
H
H
Suzuki
N
N
Matsumoto
H
H
Kanazawa
I
I
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood / Q000134:cerebrospinal fluid*; D001794:Blood Pressure; D016232:Endothelins / Q000097:blood / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged
D016232:Endothelins