Effect of activated protein C on impaired fibrinolysis in rats with obstructive jaundice.
We studied the effect of activated protein C (APC) on impaired fibrinolysis using a rat model in which disseminated intravascular coagulation (DIC) is induced by the intravenous injection of endotoxin in rats with obstructive jaundice. An intravenous injection of endotoxin in rats with obstructive jaundice resulted in pulmonary hemorrhages and a marked increase in the plasma levels of tissue-type plasminogen activator (t-PA) antigen and plasminogen activator inhibitor activity. Prophylaxis with APC before the injection of endotoxin resulted in a decrease of the number of lung hemorrhages and an accelerated release of t-PA antigen. Thus, DIC in obstructive jaundice may be due to impairment of fibrinolysis and an increased susceptibility of endothelial cells to endotoxin. APC may be effective as a treatment for patients with obstructive jaundice associated with DIC.
Uchino
R
R
Department of Surgery, Kumamoto Rosai Hospital, Yatsushiro, Japan.
Saitoh
N
N
Hiraoka
T
T
Miyauchi
Y
Y
D000818:Animals; D002779:Cholestasis / Q000097:blood* / Q000150:complications; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000139:chemically induced / Q000209:etiology; D004731:Endotoxins; D004926:Escherichia coli; D005342:Fibrinolysis / Q000187:drug effects*; D006470:Hemorrhage / Q000139:chemically induced / Q000517:prevention & control; D007124:Immunoenzyme Techniques; D007275:Injections, Intravenous; D008171:Lung Diseases / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D015849:Plasminogen Inactivators / Q000097:blood; D011486:Protein C / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D010959:Tissue Plasminogen Activator / Q000097:blood
D004731:Endotoxins; D015849:Plasminogen Inactivators; D011486:Protein C; D010959:Tissue Plasminogen Activator