Familial resemblance of blood pressure with residual household environmental effects in consanguineous and nonconsanguineous families from Andhra Pradesh, India.
Familial aggregation of blood pressure (BP), both systolic (SBP) and diastolic (DBP), was examined in consanguineous and nonconsanguineous families from southern India. Path analysis of BP suggests inbreeding effects, with the genetic variance for SBP being lower in the sample that included inbred families. Specifically, genetic heritability for SBP was 38% in the nonconsanguineous sample but only 23% in the combined sample. Genetic heritability for DBP (30%) did not vary by sample, nor were sample differences in cultural heritability detected for either SBP (over 35%) or DBP (about 18%). These findings are remarkably similar to those in a French-Canadian population of Quebec; both reports found a considerably larger effect of the home environment on BP than previous studies.
Rice
T
T
Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110.
Nirmala
A
A
Reddy
P C
PC
Ramana
P V
PV
Krishna
K S
KS
Rao
D C
DC
D001794:Blood Pressure / Q000235:genetics*; D003241:Consanguinity; D003906:Developing Countries; D005260:Female; D005828:Genetics, Population; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D007194:India; D008019:Life Style; D008297:Male; D008957:Models, Genetic; D010641:Phenotype; D012931:Social Environment