Cardiovascular and pulmonary effects of atropine reversal of oxymorphone-induced bradycardia in dogs.
Oxymorphone was administered intravenously (IV) to 10 dogs (0.4 mg/kg initial dose followed by 0.2 mg/kg three times at 20-minute intervals). Four hours after the last dose of oxymorphone, heart rates were less than 60 bpm in six dogs. After atropine (0.01 mg/kg IV) was administered, heart rate decreased in five dogs and sinus arrhythmia or second degree heart block occurred in four of them. A second injection of atropine (0.01 mg/kg IV) was administered 5 minutes after the first and the heart rates increased to more than 100 bpm in all six dogs. Ten minutes after the second dose of atropine, heart rate, cardiac output, left ventricular minute work, venous admixture, and oxygen transport were significantly increased, whereas stroke volume, central venous pressure, systemic vascular resistance, and oxygen extraction ratio were significantly decreased from pre-atropine values. The PaCO2 increased and the PaO2 decreased but not significantly. The oxymorphone-induced bradycardia did not produce any overtly detrimental effects in these healthy dogs. Atropine reversed the bradycardia and improved measured cardiovascular parameters.
Copland
V S
VS
Department of Surgery, School of Veterinary Medicine, University of California, Davis 95616.
Haskins
S C
SC
Patz
J D
JD
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D001784:Blood Gas Analysis / Q000662:veterinary; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs / Q000502:physiology*; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects*; D010100:Oxygen / Q000097:blood; D010111:Oxymorphone / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D012119:Respiration / Q000187:drug effects*
D002245:Carbon Dioxide; D001285:Atropine; D010111:Oxymorphone; D010100:Oxygen