title: [Refractory effect and alloimmunization after transfusion of thrombocytes].
abstract: The authors discuss possible ways for prevention of alloimmunization with HLA-antigen in acute leukemia patients after platelet transfusions. Prevention or delay of HLA-alloimmunization is possible when platelets of single random donor are used instead of pooled random donor platelets for transfusions. The effect of leucocyte removal from platelet concentrates and ultraviolet irradiation of platelet concentrates under conditions of blood bank on alloimmunization and refractoriness incidence has been considered.
authors.forename: R I
authors.initials: RI
authors.lastname: Volkova
authors.forename: V A
authors.initials: VA
authors.lastname: Agranenko
mesh_terms: D000707:Anaphylaxis / Q000209:etiology* / Q000276:immunology / Q000517:prevention & control; D001782:Blood Donors; D001792:Blood Platelets / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology*; D006440:Hemofiltration / Q000379:methods; D006470:Hemorrhage / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007938:Leukemia / Q000276:immunology / Q000628:therapy*; D007958:Leukocyte Count; D007962:Leukocytes / Q000276:immunology; D010976:Platelet Count; D017713:Platelet Transfusion; D065227:Transfusion Reaction
chemical_list: D006680:HLA Antigens
vernacular_title: Refrakternost' i alloimmunizatsiia pri perelivanii trombotsitov.