Effects on renal function and digoxin-like immunoreactivity produced by methimazole in low-renal mass hypertension.
This study evaluates the effects of methimazole, an antithyroid drug, on blood pressure, digoxin-like immunoreactive factor (DLIF) production and other variables related to salt and water metabolism in low-renal mass (LRM) hypertension. Drinking administration of methimazole (0.025%) from replacement of water by the 1% NaCl solution maintained the blood pressure of low-renal mass rats at normal levels during four weeks after hypertension induction. Serum and urinary excretion of DLIF were significantly increased in LRM rats with respect to controls; in all tests, the highest values of DLIF were found in LRM-methimazole treated (LRM-M) rats. Urinary excretion of DLIF showed positive correlations with diuresis and natriuresis in all three groups (control, LRM and LRM-M rats). However, the correlation between DLIF and sodium disappeared when both factors were expressed as a function of their concentrations. These results indicate that methimazole prevents LRM hypertension and suggest that DLIF might not represent the putative natriuretic hormone. Other findings were that methimazole-treatment reduced renal compensatory hypertrophy subsequent to subtotal nephrectomy, and did not modify the characteristic polyuria-polydypsia in this type of hypertension.
Andrade
J L
JL
Departamento de Bioquímica, Facultad de Medicina, Granada, Spain.
Haro
J M
JM
Sabio
J M
JM
Garcia del Rio
C
C
Vargas
F
F
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism* / Q000652:urine; D002298:Cardenolides; D004077:Digoxin / Q000378:metabolism* / Q000652:urine; D006973:Hypertension / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D007552:Isotonic Solutions / Q000494:pharmacology; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008713:Methimazole / Q000494:pharmacology*; D009318:Natriuresis; D011188:Potassium / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D012462:Saline Solution, Hypertonic / Q000494:pharmacology; D012503:Saponins; D012965:Sodium Chloride / Q000494:pharmacology; D014868:Water Deprivation
D001798:Blood Proteins; D002298:Cardenolides; D007552:Isotonic Solutions; D012462:Saline Solution, Hypertonic; D012503:Saponins; C034504:digoxin-like factors; D012965:Sodium Chloride; D008713:Methimazole; D004077:Digoxin; D011188:Potassium