Effect of potassium chloride on gastric acid secretion and gastrin release in humans.
The effect of potassium chloride on gastric acid secretion and gastrin release was studied in 6 healthy human beings. On 3 separate days and in random order, subjects received an intragastric infusion of 0.5 L of a glucose-saline solution to which had been added 40 mmol KCl, 40 mmol NaCl, or no additional salts. All test solutions stimulated acid secretion and gastrin release to a similar degree. While potassium ions play a critical role in acid secretion by parietal cells (via the H+, K(+)-ATPase), KCl administered into the gastric lumen at a concentration of 80 mmol/L has no effect on acid secretion in man.
Feldman
M
M
Medical Service, Department of Veterans Affairs Medical Center, Dallas, Texas 75216.
Goldschmiedt
M
M
D000328:Adult; D004311:Double-Blind Method; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005746:Gastric Emptying / Q000187:drug effects; D005755:Gastrins / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols; D011189:Potassium Chloride / Q000494:pharmacology*
D005755:Gastrins; D011092:Polyethylene Glycols; D011189:Potassium Chloride