Intrauterine insemination after ovarian stimulation as a treatment for subfertility because of subnormal semen: a prospective randomized controlled trial.
OBJECTIVE
To determine whether intrauterine insemination (IUI) after ovarian stimulation with human menopausal gonadotropin (hMG) gives a better pregnancy rate (PR) than natural intercourse in couples with subfertility because of subnormal semen.


METHODS
Prospective randomized controlled trial.


METHODS
University based subfertility clinic.


METHODS
Couples with subnormal semen as the only identifiable cause of subfertility.


METHODS
In control cycles, the couples had natural intercourse. In IUI cycles, IUI was performed after ovarian stimulation with hMG and human chorionic gonadotropin.


METHODS
The clinical PRs and complications of IUI cycles and control cycles were compared.


RESULTS
There were six clinical pregnancies in the 42 IUI cycles, whereas there was no clinical pregnancy in the 42 control cycles. The clinical PR in IUI cycles (14.3% per cycle) was significantly higher than that in control cycles (0%). Six patients (14.3%) developed moderate degree of ovarian hyperstimulation syndrome in IUI cycles.


CONCLUSIONS
Intrauterine insemination after ovarian stimulation with hMG is useful in treatment of subfertile couples with subnormal semen.
Ho
P C
PC
Department of Obstetrics and Gynecology, University of Hong Kong.
So
W K
WK
Chan
Y F
YF
Yeung
W S
WS
D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000628:therapy*; D007317:Insemination, Artificial, Homologous; D008297:Male; D008596:Menotropins / Q000627:therapeutic use*; D011247:Pregnancy; D011446:Prospective Studies; D012661:Semen / Q000502:physiology*; D013076:Sperm Count; D013081:Sperm Motility; D013094:Spermatozoa / Q000002:abnormalities
D006063:Chorionic Gonadotropin; D004958:Estradiol; D008596:Menotropins