Quantification of the ocular reactions to microfilaricides in the chemotherapy of onchocerciasis.
Severe adverse systemic and ocular reactions have complicated the chemotherapy of onchocerciasis. A method for the quantification of ocular reactions to chemotherapy has been devised at the Onchocerciasis Chemotherapy Research Centre, at Hohoe, in Ghana. Symptoms, visual function, anterior segment inflammation and disease of the posterior segment are graded. The information is entered into a computerised database which allows reaction scores to be calculated both for individual patients, and for treatment groups. This system enables comparison of adverse ocular reactions to various new chemotherapeutic regimens.
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Onchocerciasis Chemotherapy Research Centre, Hohoe Hospital, Ghana.
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Awadzi
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D000869:Anterior Eye Segment; D005128:Eye Diseases / Q000139:chemically induced*; D005369:Filaricides / Q000009:adverse effects*; D005451:Fluorescein Angiography; D006801:Humans; D015827:Onchocerciasis, Ocular / Q000188:drug therapy*; D010857:Pigment Epithelium of Eye / Q000187:drug effects; D014792:Visual Acuity / Q000187:drug effects; D014794:Visual Fields / Q000187:drug effects
D005369:Filaricides