title: [Seasonal and circadian fluctuations in blood biochemical indicators in mice in natural conditions and exposed to constant light].
abstract: The fluctuations of activity of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and those of the levels of protein, glucose, cholesterol, bilirubin, creatinine, blood urea nitrogen, K+, Cl-, Na+ in blood plasma of mice in natural conditions (NC) and exposed to constant light (CL) were studied in different seasons of the year (in January, April, July, October) on days 18, 24, 6 (at 12 o'clock). Most indices both in NC and CL animals had seasonal rhythm similar for each of them. This proves a primary effect of environmental geoclimatic factors of formation of circadian periodicals as compared to desynchronization in constant light revealed by Kosinor analysis in winter (acrophase from 14.16 till 16.32 o'clock) and autumn (acrophase from 23.03 til 4.40 o'clock). During the same seasons one can observe the maximum desynchronization influences of constant light, which leads to abrupt falling (to the 10-fold and more) of the fluctuations amplitude and in some cases to stabilization of circadian rhythm.
authors.forename: M V
authors.initials: MV
authors.lastname: Berezkin
authors.forename: E N
authors.initials: EN
authors.lastname: Gratsinskiĭ
authors.forename: V F
authors.initials: VF
authors.lastname: Kudinova
authors.forename: A N
authors.initials: AN
authors.lastname: Batygov
authors.forename: L E
authors.initials: LE
authors.lastname: Ponomareva
authors.forename: O A
authors.initials: OA
authors.lastname: Prikazchikova
authors.forename: G N
authors.initials: GN
authors.lastname: Zhukova
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001769:Blood / Q000378:metabolism*; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D002940:Circadian Rhythm; D004573:Electrolytes / Q000097:blood; D008027:Light; D008297:Male; D051379:Mice; D012621:Seasons
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D004573:Electrolytes; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
vernacular_title: Sezonnye i sutochnye kolebaniia biokhimicheskikh pokazateleĭ krovi u mysheĭ v estestvennykh usloviiakh i pri postoiannom osveshchenii.