[Effect of biogenic amines on glycogen degradation in isolated rat hepatocytes].
Serotonin and tyramine affected dissimilarly the enzyme activity involved in degradation of glycogen in isolated rat hepatocytes. Serotonin inhibited hydrolytic enzymes acid alpha-glucosidase, alpha-amylase and amylo-1,6-glucosidase but activated phosphorylase inducing a decrease of glycogen content in cells. Tyramine inhibited acid alpha-glucosidase and amylo-1,6-glucosidase, did not affect the alpha-amylase and phosphorylase activities and increased content of glycogen in cells. Tyramine may be used as stimulator of glycogen accumulation in liver cells.
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D000818:Animals; D001679:Biogenic Amines / Q000494:pharmacology*; D002478:Cells, Cultured; D006004:Glycogen Debranching Enzyme System / Q000037:antagonists & inhibitors; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors; D008099:Liver / Q000166:cytology / Q000201:enzymology / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism*; D008297:Male; D051381:Rats; D000516:alpha-Amylases / Q000037:antagonists & inhibitors
D001679:Biogenic Amines; D006004:Glycogen Debranching Enzyme System; D008112:Liver Glycogen; D006026:Glycoside Hydrolases; D000516:alpha-Amylases; C030563:amylo-1,6-glucosidase
Vliianie biogennykh aminov na degradatsiiu glikogena v izolirovannykh gepatotsitakh krysy.