title: [X-ray diffraction studies on tolbutamide solid dispersion].
abstract: D860 (tolbutamide) solid dispersions prepared with urea, polyvinyl pyrrolidone (PVP), and polyethylene glycal (PEG) 6000 as carriers were studied by X-ray diffraction, relating to their dissolution rates. D860 in D860-PVP dispersion was shown to be in an amorphous state and to have greater dissolution rate. D860-urea and D860-PEG melts were found to be partly in miscible solid solution state and partly in microcrystal state and possess higher activity and greater dissolution rate. D860-PEG coprecipitate was a physical mixture and its dissolution rate is slower than its melt. No variation in the crystal structure of the D860 dispersions was observed during the ageing test.
authors.affiliation: Department of Pharmacy, Lanzhou Medical College.
authors.forename: X
authors.initials: X
authors.lastname: Ma
authors.forename: S K
authors.initials: SK
authors.lastname: Rong
authors.forename: Q Q
authors.initials: QQ
authors.lastname: Wu
authors.forename: G X
authors.initials: GX
authors.lastname: Zhou
mesh_terms: D004337:Drug Carriers; D011092:Polyethylene Glycols; D011205:Povidone; D014044:Tolbutamide / Q000737:chemistry*; D014508:Urea; D014961:X-Ray Diffraction
chemical_list: D004337:Drug Carriers; D011092:Polyethylene Glycols; D014508:Urea; D014044:Tolbutamide; D011205:Povidone