title: Comparative study of oral versus injectable vitamin K in neonates.
abstract: One hundred term exclusively breast fed babies weighing more than 2.5 kg were evaluated to determine the efficacy of various modes and doses of Vitamin K to prevent hemorrhagic disease of newborn (HDN). The babies were grouped into four categories of 25 each: Group A--1 mg Vitamin K intramuscular (Menadione sodium disulphite) at birth; Group B--0.5 mg Vitamin K intramuscular; Group C--1 mg Vitamin K orally, and group D--no Vitamin K. The prothrombin index was estimated in all babies between 36-72 hours of age. The results revealed a prothrombin index in Groups A, B, C and D as 94.98 +/- 7.64%, 95.08 +/- 9.91%, 92.51 +/- 10.10% and 80.39 +/- 15.90%, respectively. The differences between Groups A, B and C were insignificant. However, Group D, prothrombin index was significantly reduced as compared with the other three groups. It is, therefore, concluded that oral Vitamin K is as effective as injectable Vitamin K and its usage is recommended in our country to reduce complications and costs of parenteral therapy.
authors.affiliation: Department of Pediatrics and Hematology, T.N.M. College, Bombay.
authors.forename: S
authors.initials: S
authors.lastname: Malik
authors.forename: R H
authors.initials: RH
authors.lastname: Udani
authors.forename: S K
authors.initials: SK
authors.lastname: Bichile
authors.forename: R M
authors.initials: RM
authors.lastname: Agrawal
authors.forename: A T
authors.initials: AT
authors.lastname: Bahrainwala
authors.forename: S
authors.initials: S
authors.lastname: Tilaye
mesh_terms: D000284:Administration, Oral; D001942:Breast Feeding; D005260:Female; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D007273:Injections, Intramuscular; D008297:Male; D011446:Prospective Studies; D011517:Prothrombin Time; D014812:Vitamin K / Q000008:administration & dosage* / Q000627:therapeutic use; D006475:Vitamin K Deficiency Bleeding / Q000517:prevention & control*
chemical_list: D014812:Vitamin K