title: Low levels of somatomedin C in patients with the fibromyalgia syndrome. A possible link between sleep and muscle pain.
abstract: OBJECTIVE
  Fibromyalgia is a common syndrome of musculoskeletal pain and fatigue. Lacking distinctive tissue or laboratory correlations, it has often been considered a form of "psychogenic rheumatism." In the present study, the notion that the stage-4 sleep anomaly typically seen in the fibromyalgia syndrome may disrupt growth hormone secretion was tested. Because growth hormone has a very short half-life, serum levels of somatomedin C were measured; somatomedin C is the major mediator of growth hormone's anabolic actions and is a prerequisite for normal muscle homeostasis.
  
  
  METHODS
  Serum levels of somatomedin C were measured in 70 female fibromyalgia patients and 55 healthy controls, using a peptide-specific radioimmunoassay.
  
  
  RESULTS
  Significantly lower levels of somatomedin C were observed in the fibromyalgia patients compared with controls (mean +/- SD 124.7 +/- 47 ng/ml versus 175.2 +/- 60 ng/ml; P = 0.000001). These results could not be explained by concomitant therapy or by weight, and in a subset of 21 patients in whom this was investigated, there was no correlation with various indices of disease activity.
  
  
  CONCLUSIONS
  These findings indicate that there is a distinctive disruption of the growth hormone-somatomedin C neuroendocrine axis in a majority of fibromyalgia patients. It is hypothesized that this abnormality may explain the link between disturbed sleep and predisposition to muscle pain.
authors.affiliation: Division of Arthritis and Rheumatic Diseases, Oregon Health Sciences University, Portland 97201.
authors.forename: R M
authors.initials: RM
authors.lastname: Bennett
authors.forename: S R
authors.initials: SR
authors.lastname: Clark
authors.forename: S M
authors.initials: SM
authors.lastname: Campbell
authors.forename: C S
authors.initials: CS
authors.lastname: Burckhardt
mesh_terms: D000328:Adult; D005260:Female; D005356:Fibromyalgia / Q000097:blood* / Q000209:etiology; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008875:Middle Aged; D011863:Radioimmunoassay; D012044:Regression Analysis; D012893:Sleep Wake Disorders / Q000150:complications*
chemical_list: D007334:Insulin-Like Growth Factor I