Fluorescence in situ mapping of the human nuclear NAD+ ADP-ribosyltransferase gene (ADPRT) and two secondary sites to human chromosomal bands 1q42, 13q34, and 14q24.
A 3.5-kb cDNA probe containing the 23 exons from the coding sequence of human nuclear NAD+ ADP-ribosyltransferase (poly [ADP-ribose] polymerase [ADPRT], E.C.2.4.2.30) was used to map the gene and two additional sites by nonisotopic in situ chromosomal hybridization. The previous localization of the structural gene on 1q42 was confirmed. Two other hybridization peaks on 13q34 and 14q24 suggested the presence of ADPRT pseudogenes.
Baumgartner
M
M
Institut für Biochemie, Universität Innsbruck, Austria.
Schneider
R
R
Auer
B
B
Herzog
H
H
Schweiger
M
M
Hirsch-Kauffmann
M
M
D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002882:Chromosomes, Human, Pair 13; D002883:Chromosomes, Human, Pair 14; D015342:DNA Probes / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D011065:Poly(ADP-ribose) Polymerases / Q000235:genetics*; D011544:Pseudogenes / Q000235:genetics
D015342:DNA Probes; D011065:Poly(ADP-ribose) Polymerases