title: [Homology and evolution of gene orders: combinatorial measure of synteny group similarity and simulation of the evolution process].
abstract: Combinatorial measure of synteny group similarity allowing quantitative comparison of evolutional divergence of genomes with the known distribution of homologous genes along the chromosomes is proposed. Computer simulation of chromosome evolution process resulting in gene localization changes was performed. It is sufficient to fix about 50 large rearrangements, like chromosome breakages, fusions and translocations for disappearance of significant similarity between the daughter and parental genomes, in respect of gene distribution in synteny groups.
authors.forename: I A
authors.initials: IA
authors.lastname: Zakharov
authors.forename: V S
authors.initials: VS
authors.lastname: Nikiforov
authors.forename: E V
authors.initials: EV
authors.lastname: Stepaniuk
mesh_terms: D005075:Biological Evolution; D002874:Chromosome Mapping; D003198:Computer Simulation; D015321:Gene Rearrangement; D015894:Genome, Human; D006801:Humans; D008957:Models, Genetic; D012689:Sequence Homology, Nucleic Acid; D014178:Translocation, Genetic / Q000235:genetics
vernacular_title: Gomologiia i évoliutsiia gennykh poriadkov: kombinatornaia mera skhodstva grupp sintenii i modelirovanie évoliutsionnogo protsessa.