[An experimental study of anti-amnestic activity of piracetam in orchidectomized rats].
The decrease of learning ability by 50% as assessed by passive avoidance test and the increase 28% of microviscosity of synaptosomal membranes from brain cortex were observed in rats in a month after orchidectomy as compared with that of intact or sham--operated animals. The treatment of orchidectomized rats with piracetam either by single application or in the course of 10 days applications in the daily dose of 250 mg/kg intraperitoneally failed to improve learning ability of animals in passive avoidance test and to produce a normalizing effect on the structure of membrane lipid matrix. The testosterone content in blood of orchidectomized rats was 10 times lower as compared with control and was not affected by treatment with piracetam.
Burov
Iu V
IuV
Terekhina
A I
AI
Kadysheva
L V
LV
Voronin
A E
AE
Gritsina
G I
GI
Kirilina
V P
VP
D000818:Animals; D001362:Avoidance Learning; D002540:Cerebral Cortex / Q000473:pathology; D007858:Learning / Q000187:drug effects*; D008297:Male; D008563:Membrane Lipids / Q000032:analysis; D009919:Orchiectomy; D010889:Piracetam / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013574:Synaptosomes / Q000473:pathology; D013739:Testosterone / Q000097:blood; D013997:Time Factors
D008563:Membrane Lipids; D013739:Testosterone; D010889:Piracetam
Eksperimental'noe izuchenie antiamnesticheskoĭ aktivnosti piratsetama u orkhidéktomirovannykh krys.