Effect of platelet-poor plasma from patients with neurofibromatosis on the growth of cultured neurofibroma-derived fibroblast-like cells.
The effect of platelet-poor plasma from patients with von Recklinghausen's disease (neurofibromatosis, NF) on the cell growth of cultured neurofibroma-derived fibroblast-like cells (NF fibroblast-like cells grown from explant cultures of cutaneous neurofibromas) was examined. Platelet-poor plasma and sera from nine NF patients and nine control individuals were examined. When comparing platelet-poor plasma from patients with NF with control individuals, the former stimulated the proliferation of fibroblast-like cells derived from neurofibromas, not that of normal fibroblasts.
Nogita
T
T
Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
Takehara
K
K
Moro
A
A
Otsuka
F
F
Ishibashi
Y
Y
D000328:Adult; D001792:Blood Platelets; D002455:Cell Division; D005260:Female; D005347:Fibroblasts / Q000473:pathology* / Q000502:physiology; D006801:Humans; D008297:Male; D009456:Neurofibromatosis 1 / Q000097:blood* / Q000503:physiopathology; D014407:Tumor Cells, Cultured