title: Delayed primary anastomosis for esophageal atresia: 18 months' to 11 years' follow-up.
abstract: In 1977 we started treating babies with isolated esophageal atresia by delayed primary anastomosis and in 1981 reported our early experience in five cases treated between 1977 and 1979. Since 1979, 11 further consecutive cases have been managed by initial gastrostomy followed by delayed primary esophageal anastomosis. Their mean gestation was 35 weeks (range, 28 to 40 weeks) and mean birth weight was 2,040 g (range, 1,140 to 2,720 g). The esophageal gap between the two ends when assessed initially at fluoroscopy ranged from 2.2 to 4.5 cm (mean, 3.2 cm). Age at delayed primary anastomosis ranged from 6 to 20 weeks. Anastomotic leak occurred in three babies in the immediate postoperative period and all were successfully managed conservatively. Eight of the 11 patients developed anastomotic strictures; seven cases required 1 to 5 esophageal dilatations. One patient who did not respond to multiple esophageal dilatations required resection of an esophageal stricture. One patient died at 15 months of age of unrelated causes. The 10 surviving patients have been followed-up from 18 months to 11 years. At follow-up, seven patients were eating normally. Three patients had swallowing difficulties and all three were found to have esophageal strictures on barium swallow, two of them also had gross esophageal reflux and hiatus hernia. The height and weight in the 10 patients varied from 3rd centile to 75th centile. Delayed primary anastomosis is feasible in cases of isolated esophageal atresia and the patient's own esophagus is the best. A more aggressive approach should be applied to gastroesophageal reflux in these patients.
authors.affiliation: Children's Research Centre, Our Lady's Hospital for Sick Children, Dublin, Ireland.
authors.forename: P
authors.initials: P
authors.lastname: Puri
authors.forename: G K
authors.initials: GK
authors.lastname: Ninan
authors.forename: N S
authors.initials: NS
authors.lastname: Blake
authors.forename: R J
authors.initials: RJ
authors.lastname: Fitzgerald
authors.forename: E J
authors.initials: EJ
authors.lastname: Guiney
authors.forename: B
authors.initials: B
authors.lastname: O'Donnell
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods*; D004933:Esophageal Atresia / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D004947:Esophagus / Q000000981:diagnostic imaging / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005764:Gastroesophageal Reflux / Q000209:etiology; D005774:Gastrostomy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011859:Radiography; D013997:Time Factors; D016896:Treatment Outcome