title: Birth defects in Norway by levels of external and food-based exposure to radiation from Chernobyl.
abstract: In Norway, external doses of radiation resulting from fallout from the Chernobyl nuclear accident were estimated from detailed measurements, including soil deposition patterns. Internal doses were estimated from measurements of radioactive cesium in meat and milk supplies. The doses were calculated as average monthly doses for each of 454 municipalities during 36 consecutive months after the accident in spring 1986. Prospectively collected data on all newborns listed in the Medical Birth Registry of Norway who were conceived in the period May 1983-April 1989 were used to assess possible dose-response relations between estimated external and food-based exposures and congenital malformations and some other conditions. A positive association was observed between total radiation dose (external plus food-based) and hydrocephaly, while a negative association was observed for Down's syndrome. However, an important conclusion of the study was that no associations were found for conditions previously reported to be associated with radiation, i.e., small head circumference, congenital cataracts, anencephaly, spina bifida, and low birth weight. Potential sources of bias, including exposure misclassification and incomplete ascertainment of cases, are discussed.
authors.affiliation: Medical Birth Registry of Norway, University of Bergen, Norway.
authors.forename: R T
authors.initials: RT
authors.lastname: Lie
authors.forename: L M
authors.initials: LM
authors.lastname: Irgens
authors.forename: R
authors.initials: R
authors.lastname: Skjaerven
authors.forename: J B
authors.initials: JB
authors.lastname: Reitan
authors.forename: P
authors.initials: P
authors.lastname: Strand
authors.forename: T
authors.initials: T
authors.lastname: Strand
mesh_terms: D000016:Abnormalities, Radiation-Induced / Q000453:epidemiology* / Q000209:etiology; D000059:Accidents; D004307:Dose-Response Relationship, Radiation; D004314:Down Syndrome / Q000453:epidemiology; D004781:Environmental Exposure / Q000009:adverse effects* / Q000032:analysis; D005260:Female; D005507:Food Contamination, Radioactive / Q000032:analysis; D006801:Humans; D006849:Hydrocephalus / Q000453:epidemiology / Q000209:etiology; D007231:Infant, Newborn; D008297:Male; D009664:Norway / Q000453:epidemiology; D009688:Nuclear Reactors; D014455:Ukraine