Prediction of sotalol-induced maximum steady-state QTc prolongation from single-dose administration in healthy volunteers.
The relationship between racemic sotalol plasma concentrations and QTc interval prolongation after both single-dose and repeated administration of three sotalol oral doses was studied in a randomized crossover protocol performed in 10 healthy volunteers. QTc interval increase was significant after the three single-dose sotalol administrations and was significantly related to the administered dose (p < 0.0001). In 21 of 30 analyses, QTc interval was linearly correlated with sotalol plasma concentrations. After the 320 mg dose, the linear model was a best fit for 90% of the cases, and no hysteresis was observed. After repeated sotalol administration, 69 of 87 QTc interval measurements at steady state could be predicted from the plasma concentration versus effect relationship established after single-dose 320 mg administration. Seventeen of 18 errors (94%) corresponded to QTc intervals that were significantly lower than predicted. These findings suggest that a short-term individual linear model determined after a 320 mg test dose of sotalol allows a good prediction of expected maximal increase in QTc duration in healthy subjects.
Le Coz
F
F
Clinical Pharmacology Unit, Saint-Antoine University Hospital, Paris, France.
Funck-Brentano
C
C
Poirier
J M
JM
Kibleur
Y
Y
Mazoit
F X
FX
Jaillon
P
P
D000284:Administration, Oral; D000328:Adult; D000704:Analysis of Variance; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography / Q000187:drug effects*; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D012016:Reference Values; D012044:Regression Analysis; D013015:Sotalol / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*
D013015:Sotalol