title: Accumulation of fluoxetine and norfluoxetine in human brain during therapeutic administration.
abstract: In vivo 19fluorine nuclear magnetic resonance spectroscopy was used to measure the brain concentration of fluoxetine and norfluoxetine in five patients with obsessive-compulsive disorder and three with major depression. The mean brain:plasma ratio of the parent drug plus the metabolite was significantly elevated to 2.6 (SD = 1.0) (95% confidence interval = 1.9-3.3). This accumulation may have implications for understanding both the therapeutic and the toxic effects of fluoxetine.
authors.affiliation: MGH-NMR Center, Massachusetts General Hospital-East, Charlestown.
authors.forename: P F
authors.initials: PF
authors.lastname: Renshaw
authors.forename: A R
authors.initials: AR
authors.lastname: Guimaraes
authors.forename: M
authors.initials: M
authors.lastname: Fava
authors.forename: J F
authors.initials: JF
authors.lastname: Rosenbaum
authors.forename: J D
authors.initials: JD
authors.lastname: Pearlman
authors.forename: J G
authors.initials: JG
authors.lastname: Flood
authors.forename: P R
authors.initials: PR
authors.lastname: Puopolo
authors.forename: K
authors.initials: K
authors.lastname: Clancy
authors.forename: R G
authors.initials: RG
authors.lastname: Gonzalez
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism*; D016001:Confidence Intervals; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D005461:Fluorine; D005473:Fluoxetine / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D005473:Fluoxetine; D005461:Fluorine; C036139:norfluoxetine