Lipoproteins in preterm and small-for-gestational-age infants during the first week of life.
Plasma lipoprotein levels and composition have been determined in preterm and small-for-gestational-age (SGA) infants, and compared to full-term infants, during the first week of life. Significantly lower levels of HDL and higher levels of VLDL were found in both preterm and SGA infants in comparison to full-term healthy infants. These results suggest a low capacity to metabolize VLDL. Preterm infants showed a behaviour similar to full-term infants with regard to the changes in lipoprotein composition. Small-for-gestational-age infants showed a higher lipoprotein lipid content than preterm infants. A low ratio of cholesteryl ester to free cholesterol (CE/FC) was found in both preterm and SGA infants suggesting a reduced lecithin: cholesterol acyl transferase (LCAT) activity. In preterm infants we observed no changes in the CE/FC ratio during the first week of life, whereas in SGA infants this ratio increased after birth.
Morillas
J M
JM
Department of Neonatology, Maternal-Infant Hospital of Granada, Spain.
Moltó
L
L
Robles
R
R
Gil
A
A
Sánchez-Pozo
A
A
D001053:Apolipoproteins / Q000097:blood*; D001724:Birth Weight; D002784:Cholesterol / Q000097:blood*; D005069:Evaluation Studies as Topic; D005865:Gestational Age; D006801:Humans; D007225:Infant Food / Q000032:analysis; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D007236:Infant, Small for Gestational Age / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D015430:Weight Gain
D001053:Apolipoproteins; D008074:Lipoproteins; D002784:Cholesterol