title: [Antigen detection in the murine models of systemic candidiasis].
abstract: We compared two latex agglutination tests for serum candidal antigen in murine models of systemic infection and gastrointestinal colonization. In the intravascular-infection model, mannan detection test was positive at 2 hours after inoculation, but Cand-Tec was less sensitive than mannan detection test in this model. In the gastrointestinal colonization model followed by systemic infection in neutropenic mice, the mannan antigen test became positive after 3 weeks of colonization with increased number of Candida of the stool, and Cand-Tec became positive after 5 weeks in neutropenic mice.
authors.affiliation: Second Department of Internal Medicine, School of Medicine, Nagasaki University.
authors.forename: K
authors.initials: K
authors.lastname: Mitsutake
authors.forename: S
authors.initials: S
authors.lastname: Kohno
authors.forename: H
authors.initials: H
authors.lastname: Matsuda
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshitomi
authors.forename: Y
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Y
authors.initials: Y
authors.lastname: Higashiyama
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Iwamoto
authors.forename: S
authors.initials: S
authors.lastname: Maesaki
authors.forename: M
authors.initials: M
authors.lastname: Kaku
mesh_terms: D000818:Animals; D000946:Antigens, Fungal / Q000032:analysis*; D002176:Candida albicans / Q000276:immunology; D002177:Candidiasis / Q000276:immunology*; D004195:Disease Models, Animal; D007841:Latex Fixation Tests; D008297:Male; D008351:Mannans / Q000097:blood; D051379:Mice; D008807:Mice, Inbred BALB C
chemical_list: D000946:Antigens, Fungal; D008351:Mannans