title: [Antibiotics of the aminoglycoside group (gentamicin, sisomicin and amikacin) in the prevention and treatment of experimental plague].
abstract: Activity of aminoglycosides such as gentamicin, sisomicin and amikacin against plague microbe strains of natural origin was studied in vitro. It was also studied in prophylaxis and treatment of experimental plague infection in albino mice. The MAC of gentamicin and sisomicin for 50 strains of the plague microbe was 0.2-1.6 micrograms/ml. For the majority of the strains it was 0.4 micrograms/ml. The amikacin MICs were 0.4-3.2 and 0.8 micrograms/ml, respectively. High efficacy of gentamicin, sisomicin and amikacin was shown in prophylaxis and treatment of experimental plague infection in albino mice. The optimal doses of the antibiotics were determined. Under definite conditions such as the use of short-term regimens and higher intervals, advantages of sisomicin over gentamicin and amikacin in prophylaxis of experimental plague infection were observed.
authors.forename: A I
authors.initials: AI
authors.lastname: Shcherbaniuk
authors.forename: L N
authors.initials: LN
authors.lastname: Makarovskaia
authors.forename: O K
authors.initials: OK
authors.lastname: Bugaeva
authors.forename: I V
authors.initials: IV
authors.lastname: Kasatkina
mesh_terms: D000583:Amikacin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D003470:Culture Media; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005839:Gentamicins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D066298:In Vitro Techniques; D007273:Injections, Intramuscular; D051379:Mice; D010930:Plague / Q000188:drug therapy* / Q000382:microbiology / Q000517:prevention & control; D012853:Sisomicin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D015010:Yersinia pestis / Q000187:drug effects*
chemical_list: D003470:Culture Media; D005839:Gentamicins; D000583:Amikacin; D012853:Sisomicin
vernacular_title: Antibiotiki gruppy aminoglikozidov (gentamitsin, sizomitsin, amikatsin) v profilaktike i lechenii éksperimental'noĭ chumnoĭ infektsii.