Miliary tuberculosis with acute respiratory failure and histiocytic hemophagocytosis. Successful treatment with extracorporeal lung support and epipodophyllotoxin VP 16-213.
A 14-year-old girl with high fever, dyspnea and bilateral miliary nodules on chest X-ray, developed a rapidly progressive respiratory failure associated with histiocytic hemophagocytosis. Histologic examination of bone marrow biopsy revealed tuberculous granulomas with caseating necrosis. We report a pediatric case in which treatment with extracorporeal lung support and epipodophyllotoxin VP 16-213 was successful.
Monier
B
B
Intensive Care Department, Trousseau Hospital, Paris, France.
Fauroux
B
B
Chevalier
J Y
JY
Leverger
G
G
Nathanson
M
M
Costil
J
J
Tournier
G
G
D000293:Adolescent; D005047:Etoposide / Q000627:therapeutic use*; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D015616:Histiocytosis, Non-Langerhans-Cell / Q000150:complications / Q000628:therapy*; D006801:Humans; D011859:Radiography; D012131:Respiratory Insufficiency / Q000150:complications / Q000628:therapy*; D013577:Syndrome; D014391:Tuberculosis, Miliary / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*
D005047:Etoposide