Anti-TCR-V beta 6 breaks tolerance in female AKR, Mlsa mice inducing foetal lethality.
Immunisation with anti-TCR-V beta 6 of female AKR mice prior to and during syngeneic pregnancy resulted in neonatal lethality and eventually in abortion or foetal resorption. The sera of the hyperimmunised mothers were shown to have anti-H-2k and anti-Mlsa autoantibodies and were cytotoxic to H-2k targets in vitro and also blocked Mlsa-induced mixed lymphocyte reactions. These observations are discussed herein.
de Giorgi
L
L
Immunology Department, Medical College of the London Hospital, UK.
Matossian-Rogers
A
A
D000818:Animals; D001323:Autoantibodies / Q000097:blood; D003602:Cytotoxicity, Immunologic; D005260:Female; D005313:Fetal Death / Q000276:immunology*; D006183:H-2 Antigens; D007108:Immune Tolerance; D007114:Immunization; D066298:In Vitro Techniques; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D016747:Minor Lymphocyte Stimulatory Antigens; D011247:Pregnancy; D016693:Receptors, Antigen, T-Cell, alpha-beta
D001323:Autoantibodies; D006183:H-2 Antigens; D016747:Minor Lymphocyte Stimulatory Antigens; D016693:Receptors, Antigen, T-Cell, alpha-beta