Structural maturation of synapses in the rat superior cervical ganglion continues beyond four weeks of age.
We have examined the morphology of preganglionic synapses in the rat superior cervical ganglion (SCG) at 10 days, 4 weeks and 1 year. Between 10 days and 4 weeks the mean thickness of the postsynaptic density (PSD) increased from 45.9 +/- 0.1 nm to 52.1 +/- 1.7 nm (P = 0.017), the mean length of the PSD (0.41 +/- 0.02 microns) did not change, and the distribution of synapses on the neuronal surface changed with a decrease in the proportion of somatic and an increase in the proportion of dendritic spine synapses. Since both synapse elimination and synapse formation are occurring during this period several mechanisms may contribute to these changes. However, between 4 weeks and 1 year, when there is no net change in the number of synapses, the mean length of the PSD increased to 0.53 +/- 0.02 microns (P = 0.001), there was no change in either the mean thickness of the PSD or the distribution of the synapses but the proportion of concave ('smile') synapses increased. A comparison with previous developmental studies of synapses in cerebral cortex of rat and chicken indicate that both the nature and the rate of synapse maturation can vary between different populations of synapses.
Heath
J W
JW
Neuroscience Group, Faculty of Medicine, University of Newcastle, N.S.W., Australia.
Glenfield
P J
PJ
Rostas
J A
JA
D000375:Aging / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn; D005728:Ganglia, Sympathetic / Q000254:growth & development* / Q000648:ultrastructure; D051381:Rats; D017207:Rats, Sprague-Dawley; D013569:Synapses / Q000502:physiology / Q000648:ultrastructure*