title: Mechanoelectrical transduction, ion movement and water stasis in uromodulin.
abstract: Mechanical movement of a column of the urinary glycoprotein uromodulin modulates an applied voltage. This change is a property of the glycoprotein and its interaction with the walls of the container and is related to its capacitance. The voltage modulation is not accompanied by changes in rotationally restricted water as has been reported for hyaluronic acid. Diffusion experiments with tritiated water also support the hypothesis that uromodulin acts as a water barrier, but allows ion movement.
authors.affiliation: Department of Bioscience and Biotechnology, University of Strathclyde, Glasgow, Scotland.
authors.forename: M
authors.initials: M
authors.lastname: Mattey
authors.forename: L
authors.initials: L
authors.lastname: Naftalin
mesh_terms: D004563:Electrochemistry; D006801:Humans; D007477:Ions; D009088:Mucoproteins / Q000737:chemistry*; D011257:Pregnancy Proteins / Q000737:chemistry; D011865:Radioisotope Dilution Technique; D014316:Tritium; D058949:Uromodulin; D014867:Water
chemical_list: D007477:Ions; D009088:Mucoproteins; D011257:Pregnancy Proteins; C548612:UMOD protein, human; D058949:Uromodulin; D014867:Water; D014316:Tritium