HLA-DP polymorphism in Sudanese controls and patients with insulin-dependent diabetes mellitus.
Human leukocyte antigen (HLA) genes are candidates for susceptibility to insulin-dependent diabetes mellitus (IDDM). The association of IDDM with particular DR and DQ alleles has been reported in all populations studied, but its association with HLA-DP alleles has been controversial. To address this question we analyzed 19 DPB1 and 2 DPA1 alleles and their associations in well-characterized Sudanese (an admixture of Arab and Black) IDDM patients (n = 71) and ethnically matched controls (n = 86) using polymerase chain reaction-sequence specific oligonucleotide (PCR-SSO) typing. There were no significant differences between the patient and control groups in the DPB1 frequencies. DPB1*0201, *0401 and DPA1*01 were the most frequent alleles in both IDDM patients and control subjects. Significant positive and negative associations between DPB1 and DPA1 alleles were detected in both groups. A novel DPB1 allele included in DPB1*1701 was identified.
Magzoub
M M
MM
Faculty of Medicine, University of Gezira, Sudan.
Stephens
H A
HA
Sachs
J A
JA
Biro
P A
PA
Cutbush
S
S
Wu
Z
Z
Bottazzo
G F
GF
D000483:Alleles; D001345:Autoradiography; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000235:genetics*; D005838:Genotype; D006682:HLA-DP Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D015995:Prevalence; D013397:Sudan / Q000453:epidemiology
D006682:HLA-DP Antigens; D004247:DNA