title: Sex difference in the excretion of zenarestat in mice, rats, dogs and humans.
abstract: 1. Mice show a sex difference in the excretion of zenarestat similar to that seen in rats, but dogs and humans show no significant sex difference. 2. Female rats and mice, and both sexes of dogs and humans, appear to possess an active secretory mechanism in the renal excretion of zenarestat, which is lacking or relatively inactive in male rats and mice.
authors.affiliation: Product Development Laboratories, Fujisawa Pharmaceutical Co. Ltd., Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Fujiwara
authors.forename: Y
authors.initials: Y
authors.lastname: Esumi
mesh_terms: D000328:Adult; D000368:Aged; D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D004285:Dogs; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008875:Middle Aged; D011339:Probenecid / Q000494:pharmacology; D011485:Protein Binding; D011799:Quinazolines / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012737:Sex Factors
chemical_list: D001798:Blood Proteins; D011799:Quinazolines; C064920:FR 74366; D000449:Aldehyde Reductase; D011339:Probenecid