Circadian rhythm of plasma uric acid and handling stress-induced hyperuricemia in conscious cebus monkeys.
An apparent circadian rhythm of plasma uric acid and the effect of handling stress on plasma uric acid level in conscious cebus monkeys were demonstrated. The lowest level of plasma uric acid in the circadian rhythm occurred early in the morning and the highest, before bedtime at night. With experimental handling stress, the plasma uric acid level rose to much more than the maximum level of the circadian rhythm. Stress-induced hyperuricemia could be inhibited without an increase of urinary uric acid excretion by the minor tranquilizer diazepam at doses of more than 1 mg/kg, p.o. On the other hand, benzbromarone at 20 mg/kg, p.o. significantly inhibited the hyperuricemia with a hyperuricosuric effect, while probenecid at 50 mg/kg, p.o. had no effect on either the increased plasma uric acid or urinary uric acid excretion. Accordingly, it is concluded that the plasma uric acid level in conscious cebus monkeys easily fluctuates with experimental conditions and that the animals can be utilized to evaluate the hypouricemic and hyperuricosuric property of benzbromarone-like agents.
Shinosaki
T
T
Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
Inagaki
H
H
Nakai
T
T
Yamashita
T
T
Yonetani
Y
Y
D000818:Animals; D001553:Benzbromarone / Q000494:pharmacology; D002428:Cebus; D002940:Circadian Rhythm; D003975:Diazepam / Q000494:pharmacology; D005260:Female; D006170:Gum Arabic / Q000494:pharmacology; D006234:Handling, Psychological; D008297:Male; D011339:Probenecid / Q000494:pharmacology; D013312:Stress, Physiological / Q000097:blood; D014527:Uric Acid / Q000097:blood*
D014527:Uric Acid; D001553:Benzbromarone; D006170:Gum Arabic; D011339:Probenecid; D003975:Diazepam