Anticardiac antibodies in hypertrophic cardiomyopathy as a marker of severity.
Twenty-three patients (mean age 27 years, 15 male, 8 female) with hypertrophic cardiomyopathy (10 'obstructive', 13 'non-obstructive') mostly of the sporadic type were examined for anticardiac antibodies circulating in the peripheral blood or bound in the endomyocardial biopsy. Immunoglobulin deposition in the biopsies was found in 41% of cases of the IgG isotype. IgM and complement fixation occurred less frequently. Predominant findings in the patients sera were antimyolemmal (78%) and antifibril antibodies (43%). The patients' sera were not cytolytic except for one case indicating that neither a toxic serum factor nor antibody-mediated cardiocytolysis were operative to a significant degree in hypertrophic cardiomyopathy. The patient's lymphocytes did not demonstrate a cytotoxic effect either alone or in the presence of the autologous serum.
Maisch
B
B
Department of Internal Medicine-Cardiology, Philipps-University Marburg, Germany.
D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D015415:Biomarkers; D001706:Biopsy; D002312:Cardiomyopathy, Hypertrophic / Q000276:immunology* / Q000473:pathology; D003602:Cytotoxicity, Immunologic; D004699:Endocardium / Q000473:pathology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007150:Immunohistochemistry; D008297:Male; D009206:Myocardium / Q000276:immunology* / Q000473:pathology; D012508:Sarcolemma / Q000276:immunology
D001323:Autoantibodies; D015415:Biomarkers; D007074:Immunoglobulin G