title: Intraperitoneal administration of phosphatidylcholine improves ultrafiltration in continuous ambulatory peritoneal dialysis patients.
abstract: Reports in the literature have linked a low phosphatidylcholine content in continuous ambulatory peritoneal dialysis (CAPD) effluent to ultrafiltration loss. Clinical evidence suggests that adding phosphatidylcholine to the dialysis solution enhances ultrafiltration. A clinical study has been designed to clarify the effect of phosphatidylcholine on ultrafiltration in CAPD patients with normal ultrafiltration. A weekly measurement of the peritoneal equilibration test was conducted per patient in the hospital. A comparison between the control dialysis solution (three-week period) and the phosphatidylcholine premixed solution (three-week period) was performed on a total of 12 patients. This study shows that a phosphatidylcholine premixed dialysis solution significantly enhances ultrafiltration. Since ultrafiltration per osmotic driving force (mL/g glucose) is enhanced, the patient's glucose load per day is reduced to achieve equal ultrafiltration. In the presence of phosphatidylcholine, peritoneal permeability remained unchanged, as indicated by membrane transport characteristics. No side effects were observed.
authors.affiliation: Baxter R&D Europe, Nivelles, Belgium.
authors.forename: G
authors.initials: G
authors.lastname: Krack
authors.forename: G
authors.initials: G
authors.lastname: Viglino
authors.forename: P L
authors.initials: PL
authors.lastname: Cavalli
authors.forename: C
authors.initials: C
authors.lastname: Gandolfo
authors.forename: G
authors.initials: G
authors.lastname: Magliano
authors.forename: A
authors.initials: A
authors.lastname: Cantaluppi
authors.forename: F
authors.initials: F
authors.lastname: Peluso
mesh_terms: D001692:Biological Transport / Q000502:physiology; D015314:Dialysis Solutions / Q000737:chemistry; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007676:Kidney Failure, Chronic / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D010537:Peritoneum / Q000502:physiology; D010713:Phosphatidylcholines / Q000008:administration & dosage* / Q000627:therapeutic use; D014462:Ultrafiltration
chemical_list: D015314:Dialysis Solutions; D010713:Phosphatidylcholines