title: The retinoblastoma protein and the regulation of cell cycling.
abstract: Increasing attention has been focused on how the retinoblastoma (RB) protein regulates cell growth. Recent evidence indicates that it is a substrate for phosphorylation by cyclin-dependent kinase-cyclin complexes and suggests that this phosphorylation modulates the ability of this protein to regulate transit through the cell cycle, perhaps in its G1 phase.
authors.affiliation: Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts, Institute of Technology, Cambridge 02142-1479.
authors.forename: D
authors.initials: D
authors.lastname: Cobrinik
authors.forename: S F
authors.initials: SF
authors.lastname: Dowdy
authors.forename: P W
authors.initials: PW
authors.lastname: Hinds
authors.forename: S
authors.initials: S
authors.lastname: Mittnacht
authors.forename: R A
authors.initials: RA
authors.lastname: Weinberg
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D002455:Cell Division; D016213:Cyclins / Q000502:physiology; D016161:Genes, Retinoblastoma / Q000502:physiology; D006801:Humans; D010766:Phosphorylation; D016160:Retinoblastoma Protein / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D016213:Cyclins; D016160:Retinoblastoma Protein