Evidence for an endogenous cholecystokininergic balance in social memory.
The cholecystokinin (CCK) peptide family is involved in a variety of physiological processes, including neurotransmission in the brain. Pharmacological responses to CCK are mediated through at least two receptor subtypes termed CCK-A and CCK-B. Studies with CCK agonists suggest a possible role for CCK in cognition. Using selective antagonists and a behavioural recognition test based on the olfactory discriminative capacities of rats, we found that endogenous CCK acting at CCK-A and CCK-B receptors modulates olfactory recognition positively and negatively, respectively. CCK-B receptor antagonists therefore have facilitatory potentialities on memory processes.
Lemaire
M
M
Rhône-Poulenc Rorer Central Research, Centre de Recherches de Vitry-Alfortville, Vitry-Sur-Seine, France.
Piot
O
O
Roques
B P
BP
Böhme
G A
GA
Blanchard
J C
JC
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology; D002766:Cholecystokinin / Q000037:antagonists & inhibitors / Q000502:physiology*; D003071:Cognition / Q000187:drug effects; D020109:Devazepide; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D010671:Phenylurea Compounds; D051381:Rats; D017208:Rats, Wistar; D011949:Receptors, Cholecystokinin / Q000187:drug effects; D012903:Smell / Q000187:drug effects; D012919:Social Behavior; D014229:Triazolam / Q000494:pharmacology
D001570:Benzodiazepinones; D010671:Phenylurea Compounds; D011949:Receptors, Cholecystokinin; D014229:Triazolam; C058121:L 365260; D002766:Cholecystokinin; D020109:Devazepide