title: Carotid blood flow in anesthetized rats: effects of carotid ligation and anastomosis.
abstract: An experimental model was developed for continuous measurement of the common carotid blood flow, in the anesthetized rat, with an electromagnetic flowmeter. The mean carotid blood flow for 41 rats averaged 3.2 +/- 0.2 ml/min at an average mean arterial pressure of 101 +/- 2.5 mm Hg and arterial pO2 of 106 +/- 3.4 mm Hg, pCO2 of 38 +/- 1.2 mm Hg, and pH of 7.36 +/- 0.02. This model allowed short- and long-term carotid hemodynamic changes to be recorded after contralateral carotid ligation or end-to-side carotid anastomosis. After ligation of the contralateral carotid, blood flow through the intact carotid increased 25% (at about 1 week) and 45% (at about 5-6 months), whereas, after anastomosis, carotid blood flow increased 76% and 89% at periods comparable to those after ligation. Arterial pressure and gases did not change throughout the experimental periods. Probable mechanisms involved in these carotid hemodynamic changes are discussed.
authors.affiliation: Departamento de Fisologia, Facultad de Medicina, Universidad Autonoma, Madrid, Spain.
authors.forename: A L
authors.initials: AL
authors.lastname: García-Villalón
authors.forename: J M
authors.initials: JM
authors.lastname: Roda
authors.forename: F
authors.initials: F
authors.lastname: Alvarez
authors.forename: B
authors.initials: B
authors.lastname: Gómez
authors.forename: G
authors.initials: G
authors.lastname: Diéguez
mesh_terms: D000714:Anastomosis, Surgical; D000758:Anesthesia; D000818:Animals; D001783:Blood Flow Velocity; D017536:Carotid Artery, Common / Q000502:physiology* / Q000601:surgery; D003250:Constriction; D005260:Female; D008026:Ligation; D008297:Male; D051381:Rats; D017208:Rats, Wistar