title: Borderline malignancy of the ovary and controlled hyperstimulation, a report of 2 cases.
abstract: We report 2 patients who developed a borderline malignancy of the ovary after treatment with follicular stimulants in the context of an in vitro fertilisation (IVF) programme. In both cases, conservative surgery for the borderline malignancy was sufficient treatment. Ultimately, both patients became pregnant, 1 after IVF treatment and 1 without treatment, and both delivered healthy babies. In addition to the presentation of both cases, the literature concerning the possible risks of treating patients with high dosage, exogenously administered hormones is reviewed and the possible association between exogenous hormones and the risk of developing ovarian cancer is discussed.
authors.affiliation: Department of Obstetrics and Gynaecology, Academic Hospital Free University, Amsterdam.
authors.forename: H W
authors.initials: HW
authors.lastname: Nijman
authors.forename: C W
authors.initials: CW
authors.lastname: Burger
authors.forename: J P
authors.initials: JP
authors.lastname: Baak
authors.forename: R
authors.initials: R
authors.lastname: Schats
authors.forename: J B
authors.initials: JB
authors.lastname: Vermorken
authors.forename: P
authors.initials: P
authors.lastname: Kenemans
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000009:adverse effects; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000009:adverse effects; D006801:Humans; D008596:Menotropins / Q000009:adverse effects; D010051:Ovarian Neoplasms / Q000139:chemically induced* / Q000601:surgery; D010062:Ovulation Induction / Q000009:adverse effects*
chemical_list: D006063:Chorionic Gonadotropin; D007987:Gonadotropin-Releasing Hormone; D008596:Menotropins