Vaccination of pregnant cynomolgus monkeys with whole formalin-inactivated SIVmac251.
Five pregnant (two to three and one-half months) Macaca fascicularis seroconverted following immunization with sucrose-gradient purified and formalin-inactivated whole simian immunodeficiency virus (SIVmac251). No untoward effects on fetal maturation were observed during the immunization of the mothers. Antibodies to SIVmac251 (also those with in vitro neutralizing activity) were passively transferred to the offspring but disappeared within two to six months after birth. Antibodies to env glycoprotein (gp130) lasted longer than those against viral gag proteins (p26,p60).
Titti
F
F
Laboratory of Virology, Istituto Superiore di Sanità, Rome, Italy.
Borsetti
A
A
Geraci
A
A
Sernicola
L
L
Giuseppini
L
L
Turillazzi
G P
GP
Pace
M
M
Baroncelli
S
S
Amadori
A
A
Giovannetti
A
A
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D005314:Embryonic and Fetal Development; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D007112:Immunity, Maternally-Acquired; D007117:Immunization, Secondary / Q000662:veterinary; D008252:Macaca fascicularis; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000517:prevention & control / Q000662:veterinary; D011256:Pregnancy Outcome / Q000662:veterinary; D015531:Radioimmunoprecipitation Assay; D016097:Simian Acquired Immunodeficiency Syndrome / Q000517:prevention & control; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D014611:Vaccination / Q000662:veterinary; D015164:Vaccines, Inactivated / Q000009:adverse effects / Q000276:immunology; D014765:Viral Vaccines / Q000009:adverse effects / Q000276:immunology*
D000914:Antibodies, Viral; D015164:Vaccines, Inactivated; D014765:Viral Vaccines