Prognostic features in patients with congestive heart failure and selection criteria for cardiac transplantation.
Cardiac transplantation can be a highly successful therapeutic option for patients with end-stage congestive heart failure. Successful results, however, depend on the appropriate selection of patients for the procedure. Patients whose survival or quality of life would be compromised without cardiac transplantation and who are likely to benefit from this intensive type of treatment are potential candidates. Each patient should undergo a thorough assessment to identify any medical or psychologic contraindications to cardiac transplantation. In this review, we discuss the important predictors of survival in patients with congestive heart failure: the cause of heart failure, the patient's symptomatic and functional status, the hemodynamic and pathologic findings, the evaluation of neurohumoral activity, and the presence of cardiac arrhythmias. Once a patient with congestive heart failure has been identified as having a limited life expectancy and severely impaired quality of life, cardiac transplantation should be considered.
Edwards
B S
BS
Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, MN 55905.
Rodeheffer
R J
RJ
D000203:Activities of Daily Living; D009320:Atrial Natriuretic Factor / Q000097:blood; D004656:Enalapril / Q000627:therapeutic use; D005080:Exercise Test; D006333:Heart Failure / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D016027:Heart Transplantation / Q000592:standards*; D006353:Heart-Assist Devices; D006439:Hemodynamics; D006801:Humans; D008017:Life Expectancy; D009638:Norepinephrine / Q000097:blood; D010101:Oxygen Consumption; D011237:Predictive Value of Tests; D011379:Prognosis; D011652:Pulmonary Circulation; D013318:Stroke Volume; D015996:Survival Rate; D014655:Vascular Resistance
D004656:Enalapril; D009320:Atrial Natriuretic Factor; D009638:Norepinephrine