Low sodium diet in essential hypertension. Effect on blood cell ions and hemodynamic parameters.
The influence of salt restriction for 3 months on blood pressure, peripheral vascular resistance (observed by occlusive plethysmography), erythrocyte sodium, platelet calcium, and pH, was studied in eight untreated essential hypertensive patients. A low salt diet decreases blood pressure, vascular resistances, erythrocyte sodium, and platelet calcium, but not platelet pH. A strong positive correlation was noted between baseline platelet calcium and vascular resistances (r = 0.95, P less than .01). But during the salt restriction period, a negative correlation has been observed between the changes in these parameters, which casts doubt on the use of the platelet as a model of the smooth muscle cell.
Krzesinski
J M
JM
Nephrology-Hypertension Unit, University of Liege, Belgium.
Du
F
F
Pecqueux
M L
ML
Rorive
G
G
D000328:Adult; D001792:Blood Platelets / Q000737:chemistry*; D002118:Calcium / Q000097:blood* / Q000378:metabolism; D004039:Diet, Sodium-Restricted; D004912:Erythrocytes / Q000737:chemistry* / Q000187:drug effects; D005260:Female; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006973:Hypertension / Q000178:diet therapy*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000378:metabolism; D012964:Sodium / Q000097:blood*; D014655:Vascular Resistance / Q000187:drug effects / Q000502:physiology
D012964:Sodium; D002118:Calcium