[Considerations of the pathogenesis of parakeratosis variegata based on morphologic and molecular genetic findings].
We report on a 63-year-old woman who had been suffering from generalized parakeratosis variegata since she was 7 years old. Increased tightness of the skin was the only clinical symptom. On the whole integument except for the face, we found a fine network of hyper- and depigmentation and telangiectasias. The skin surface was dry and atrophic with fine lamellar scaling. Histological, immunohistological and ultrastructural findings indicated early infiltration by a cutaneous T-cell lymphoma. However, PCR analysis of the T-cell receptor gamma-chain genes revealed multiple amplification products favouring a polyclonal T-cell proliferation. In light of the clinical history over a period of 56 years, we consider parakeratosis variegata to be a benign, chronic inflammatory condition, as is confirmed by the results of PCR analysis in this patient.
Popp
C
C
Dermatologische Klinik, Ruhr-Universität Bochum im St. Josef-Hospital.
Bacharach-Buhles
M
M
Sterry
W
W
Griesser
H
H
Altmeyer
P
P
D003937:Diagnosis, Differential; D005260:Female; D005784:Gene Amplification / Q000235:genetics; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000235:genetics / Q000473:pathology*; D008854:Microscopy, Electron; D008875:Middle Aged; D010241:Parakeratosis / Q000235:genetics / Q000473:pathology*; D016133:Polymerase Chain Reaction; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology
D016692:Receptors, Antigen, T-Cell, gamma-delta
Uberlegungen zur Pathogenese der Parakeratosis variegata anhand morphologischer und molekulargenetischer Befunde.