Early detection of circulating anodic antigen (CAA) in a case of acute schistosomiasis mansoni with Katayama fever.
A 34-year-old male developed acute Katayama fever with fever, diarrhoea, joint pains, headache, urticarial rash and eosinophilia 18 days after falling into and spending 15 min in the water during water-skiing in the outlet of the Volta river. Low anti-schistosomal antibody titres were found by the immunofluorescence assay after 4 weeks, and the first Schistosoma mansoni eggs were found in faeces after 6 weeks. Both symptoms and eosinophilia increased the first days after treatment with oxamniquine, after which he improved gradually. Examination of frozen sera by the newly developed Magnetic Beads Antigen Capture-EIA (MBAC-EIA) later demonstrated a peak in schistosomal circulating anodic antigen (CAA) levels of diagnostic significance already 4 weeks after he was infected.
Gundersen
S G
SG
Department of Infectious Diseases, Ullevaal Hospital, Oslo University, Norway.
Ravn
J
J
Haagensen
I
I
D000328:Adult; D000818:Animals; D000947:Antigens, Helminth / Q000097:blood*; D005334:Fever / Q000175:diagnosis / Q000276:immunology; D005618:Fresh Water; D005869:Ghana; D006801:Humans; D008297:Male; D012550:Schistosoma mansoni / Q000276:immunology*; D012555:Schistosomiasis mansoni / Q000175:diagnosis / Q000276:immunology*; D013550:Swimming; D013577:Syndrome
D000947:Antigens, Helminth