title: Disturbance of spatiotemporal footfall contact patterns in the rat by TRH analogue CG3703.
abstract: Administration of TRH or its analogues to a rat changes the dynamics of locomotion resulting in shorter stance times and causes postural disturbances, including hunched back and pelvic girdle elevation. Locomotor disturbance, induced by a variety of methods, results in changes to the footfall patterns during the stance phase of locomotion. The present work investigated whether these postural and locomotor dynamic disturbances in the CG3703 treated rat were associated with changes to the pattern of paw/floor contact during locomotion. It was found that in treated animals the area of hindpaw contact increased while that of the forepaw decreased from control values. The pattern of contact changed, with hindpaw stance being shifted towards more distal elements while in the forepaw a reduction in the deployment of proximal elements without any compensating increase in distal contact was seen. These results are discussed in the context of the effects of TRH analogues on sensory and motor processing in the CNS.
authors.affiliation: Department of Biomedical Science, University of Sheffield, UK.
authors.forename: K A
authors.initials: KA
authors.lastname: Clarke
mesh_terms: D000818:Animals; D005260:Female; D005528:Foot / Q000033:anatomy & histology; D009043:Motor Activity / Q000187:drug effects*; D011187:Posture; D051381:Rats; D017208:Rats, Wistar; D013973:Thyrotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: C031926:montirelin; D013973:Thyrotropin-Releasing Hormone