Stimulatory effect of low doses of mechlorethamine on humoral response of ovalbumin-immunized rabbits--comparison with levamisole.
The effect of low doses of mechlorethamine (1-10 micrograms/kg) and levamisole (2.5 mg/kg) on humoral response of rabbits immunized twice with ovalbumin (0.1 mg/kg) was compared. It was shown that mechlorethamine given in a dose of 5 or 10 micrograms/kg potentiates the increase in the level of serum anti-ovalbumin hemagglutinins; this increase is induced both after the first and the second (after 14 days) antigen administration. Levamisole acted similarly but with much lower efficiency.
Switała
M
M
Department of Pharmacology and Toxicology, Agricultural Academy, Wrocław, Poland.
Obmińska-Domoradzka
B
B
Debowy
J
J
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D006386:Hemagglutination Tests; D006388:Hemagglutinins / Q000276:immunology; D007978:Levamisole / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008466:Mechlorethamine / Q000008:administration & dosage / Q000494:pharmacology*; D010047:Ovalbumin / Q000276:immunology*; D011817:Rabbits
D006388:Hemagglutinins; D007978:Levamisole; D008466:Mechlorethamine; D010047:Ovalbumin