Complex translocation involving Ph chromosome in a patient with typical chronic myelogenous leukemia.
We report a cytogenetic study of a patient with chronic myelogenous leukemia (CML) who, while displaying a Philadelphia (Ph) chromosome, resulting from a standard t(9;22) at diagnosis, during the chronic phase (CP) showed disappearance of the Ph and occurrence of new chromosome changes, including a marker probably arising from a translocation involving chromosome 17 and the Ph. In situ hybridization confirmed the cytogenetic appearance and demonstrated that the breakpoint on the Ph marker occurred below the BCR-ABL fusion gene.
Calabrese
G
G
Institute of Biology and Genetics, University of Chieti, Italy.
Palka
G
G
Westbrook
C A
CA
Sheer
D
D
D002872:Chromosome Deletion; D002886:Chromosomes, Human, Pair 17; D002887:Chromosomes, Human, Pair 18; D002897:Chromosomes, Human, Pair 7; D002899:Chromosomes, Human, Pair 9; D005260:Female; D006801:Humans; D017403:In Situ Hybridization; D015466:Leukemia, Myeloid, Chronic-Phase / Q000235:genetics*; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic