title: Localization of African swine fever viral antigen, swine IgM, IgG and C1q in lung and liver tissues of experimentally infected pigs.
abstract: An immunohistological study was carried out on lungs and livers of pigs experimentally infected with two different African swine fever virus (ASFV) isolates. ASFV antigen, swine immunoglobulins (IgM and IgG) and (Clq) complement were demonstrated in both organs at different stages of infection. The ASFV antigen was mainly found in mononuclear phagocytic system (MPS) cells. Immunoglobulins and complement were observed in plasma, infected and non-infected phagocytic cells and cell debris. These findings suggest the presence, in acute infection, of immune complexes which may be involved in immunopathogenic mechanisms.
authors.affiliation: Department of Histology, Veterinary Faculty, University of Córdoba, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Fernandez
authors.forename: J
authors.initials: J
authors.lastname: Perez
authors.forename: J
authors.initials: J
authors.lastname: Martin de las Mulas
authors.forename: L
authors.initials: L
authors.lastname: Carrasco
authors.forename: J
authors.initials: J
authors.lastname: Dominguez
authors.forename: M A
authors.initials: MA
authors.lastname: Sierra
mesh_terms: D000357:African Swine Fever / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D000358:African Swine Fever Virus / Q000276:immunology / Q000302:isolation & purification*; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D000936:Antigen-Antibody Complex / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis*; D015922:Complement C1q / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008099:Liver / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D008168:Lung / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D008297:Male; D013552:Swine / Q000276:immunology / Q000382:microbiology
chemical_list: D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D000956:Antigens, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015922:Complement C1q