An evaluation of inactivated infectious coryza vaccines containing a double-emulsion adjuvant system.
The efficacy of experimental inactivated infectious coryza vaccines produced by a commercial vaccine manufacturer was evaluated. The vaccines, containing as the adjuvant phase either a double-emulsion mineral oil system or aluminum-hydroxide gel, were administered to 6-week-old chickens as a single dose. Some vaccines were a monovalent product containing a Page serovar C Haemophilus paragallinarum strain, and others were a bivalent product containing both Page serovar A and serovar C strains. After 3 weeks, all chickens were challenged by infraorbital sinus inoculation of virulent H. paragallinarum, either Page serovar C (strain HP31) or Page serovar A (strain HP14). The monovalent serovar C double-emulsion-based vaccines gave significant protection against a serovar C challenge, with the level of protection varying from 60% to 100%. The monovalent serovar C aluminum-hydroxide-gel vaccine also gave significant protection (94%) against a serovar C challenge. The bivalent double-emulsion vaccine gave significant protection against challenge from both serovars (100% for serovar C and 83% for serovar A). Although no major adverse reactions were detected, some chickens receiving both the double-emulsion vaccines and the aluminum-hydroxide vaccine developed relatively minor granulomatous reactions at the site of injection.
Blackall
P J
PJ
Queensland Department of Primary Industries, Animal Research Institute, Yeerongpilly, Australia.
Eaves
L E
LE
Rogers
D G
DG
Firth
G
G
D000276:Adjuvants, Immunologic; D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology*; D002645:Chickens / Q000276:immunology* / Q000382:microbiology; D004655:Emulsions; D005069:Evaluation Studies as Topic; D006190:Haemophilus / Q000276:immunology*; D011201:Poultry Diseases / Q000382:microbiology / Q000517:prevention & control*; D012141:Respiratory Tract Infections / Q000517:prevention & control / Q000662:veterinary*; D015164:Vaccines, Inactivated / Q000276:immunology
D000276:Adjuvants, Immunologic; D001428:Bacterial Vaccines; D004655:Emulsions; D015164:Vaccines, Inactivated