Efficacy of tosufloxacin in the treatment of experimentally induced intra-abdominal infections in rats.
A reproducible experimental model of intra-abdominal infections in rats has been devised in order to simulate intra-abdominal sepsis in patients. Preoperatively, the rats were fed with lean ground beef for two weeks in order to change the intestinal flora to one similar to that of humans. A 1-cm segment of ileum was isolated on its vascular pedicle. The intestine was then divided at each end of the segment and intestinal continuity was reestablished by an end-to-end anastomosis. The segment of ileum was then returned to the abdominal cavity. This experimental model was used to compare the efficacy of tosufloxacin alone and in combination with metronidazole, with the combination gentamicin and metronidazole in the treatment of intra-abdominal infections. Eighty per cent of the untreated animals died within three days. Within three days 20% of the animals receiving tosufloxacin died. Animals treated with tosufloxacin plus metronidazole or gentamicin plus metronidazole had a significantly decreased mortality and increased cure rates during the experimental period. Only 5% of these animals died. Thus the combination of tosufloxacin and metronidazole seems to be as successful as gentamicin plus metronidazole in the treatment of intra-abdominal infections.
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Department of Microbiology, Huddinge University Hospital, Stockholm, Sweden.
Edlund
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D042462:4-Quinolones; D000038:Abscess / Q000188:drug therapy* / Q000382:microbiology; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D024841:Fluoroquinolones; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use; D009287:Naphthyridines / Q000008:administration & dosage / Q000627:therapeutic use*; D010538:Peritonitis / Q000188:drug therapy* / Q000382:microbiology; D051381:Rats; D017207:Rats, Sprague-Dawley
D042462:4-Quinolones; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D005839:Gentamicins; D009287:Naphthyridines; D008795:Metronidazole; C055185:tosufloxacin