title: Bioavailability of vinpocetine and interference of the time of application with food intake.
abstract: In a pilot study based on an open cross-over design involving four phases, the relative bioavailability of the eburnamenine derivative vinpocetine (CAS 42971-09-5) was investigated in 8 healthy volunteers in relation to different times of drug administration relative to food intake. The substance was applied orally as 10 mg film tablets. The areas under the plasma concentration-time curves (AUC) amounted to 27.3 +/- 18.1 ng.h/ml (fasting) and 42.8 +/- 27.4 up to 54.3 +/- 38.4 ng.h/ml (non-fasting, intake before and after meal, resp.). The relative bioavailability under non-fasting conditions was found to be approx. 60 to 100% higher than under fasting conditions.
authors.affiliation: Pharmacokinetics Department, Thiemann Arzneimittel GmbH, Waltrop, Fed. Rep. of Germany.
authors.forename: A
authors.initials: A
authors.lastname: Lohmann
authors.forename: E
authors.initials: E
authors.lastname: Dingler
authors.forename: W
authors.initials: W
authors.lastname: Sommer
authors.forename: K
authors.initials: K
authors.lastname: Schaffler
authors.forename: W
authors.initials: W
authors.lastname: Wober
authors.forename: W
authors.initials: W
authors.lastname: Schmidt
mesh_terms: D000328:Adult; D001682:Biological Availability; D004435:Eating; D005260:Female; D006801:Humans; D008297:Male; D014748:Vinca Alkaloids / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D014748:Vinca Alkaloids; C013983:vinpocetine