title: [In-vivo 31P-NMR-spectroscopy in patients with dilated cardiomyopathy].
abstract: In vivo 31P-NMR spectra of heart muscle were obtained in 7 patients with dilating cardiomyopathies and in 10 normal subjects, using an ISIS technique with a 1.5 Tesla body scanner (Philips Gyroscan S15) and the results of the two groups were compared. These results were easily reproduced. In patients with cardiomyopathy there was a significant (p < 0.05) reduction of the PCr/ATP ratio as an expression of abnormal energy metabolism. Two patients with mild clinical symptoms and only slightly reduced functional measurements showed no significant changes in the 31P-NMR spectrum. The patients with the largest reduction of the PCr/ATP index also showed the most marked changes in functional measurements. The PCr/ATP ratio (as also suggested by animal experiments) appears to be a suitable non-invasive indicator for the diagnosis and staging of myocardial changes in dilating cardiomyopathies.
authors.affiliation: Radiologische Universitätsklinik, Bonn.
authors.forename: W A
authors.initials: WA
authors.lastname: Kaiser
authors.forename: D
authors.initials: D
authors.lastname: Pauleit
authors.forename: F
authors.initials: F
authors.lastname: Träber
authors.forename: U
authors.initials: U
authors.lastname: Köhler
authors.forename: M
authors.initials: M
authors.lastname: Reiser
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D002311:Cardiomyopathy, Dilated / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D010761:Phosphorus Radioisotopes; D013997:Time Factors
chemical_list: D010761:Phosphorus Radioisotopes; D010725:Phosphocreatine; D000255:Adenosine Triphosphate
vernacular_title: In-vivo-31P-NMR-Spektroskopie bei Patienten mit dilatativer Kardiomyopathie.