[Salvia miltiorrhizae in the treatment of the viral myocarditis].
In Order to evaluate the effect of Salvia miltiorrhizae (SM) on the acute viral myocarditis (AVM), 60 children with AVM were studied. The patients were divided in random into two groups, group 1 treated with vit. C, ATP, CoA (n = 30), group II with SM plus vit. C, ATP, CoA (n = 30). The levels of plasma lipid peroxide (LPO), erythrocyte membrane microviscosity (EMMV), LDH, CPK, GOT and ECG in each patient were determined before and after one course of treatments respectively. The results revealed that before treatment the levels of plasma LPO and EMMV in both groups increased significantly compared with those of normal controls (n = 30, P < 0.01) respectively. There was a close correlation between LPO and EMMV (r = 0.6774, P < 0.01) and a close correlation between LPO and LDH (r = 0.5703, P < 0.01). After one course, the levels of plasma LPO and EMMV in both groups decreased significantly (compared with those before treatment, P < 0.01, respectively). But the LPO level and EMMV in group I were much higher than those in normal controls yet (P < 0.05, respectively). And LDH, GOT and ECG in nearly half of the patients in group I did not recover after one course while most patients in group II recovered. The results suggested that free radical plays an important role in the pathogenesis of AVM. SM as a good antioxidant, could protect myocardium from repairing membrane damage and clearing away free radical. This provided a new approach to treatment of viral myocarditis.
Meng
X C
XC
2nd Hospital of Harbin Medical University.
Hou
J C
JC
Jiang
Y
Y
D002648:Child; D003402:Creatine Kinase / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D009205:Myocarditis / Q000097:blood / Q000188:drug therapy* / Q000382:microbiology; D010936:Plant Extracts; D027561:Salvia miltiorrhiza; D014777:Virus Diseases / Q000097:blood / Q000188:drug therapy*
D004365:Drugs, Chinese Herbal; D008054:Lipid Peroxides; D010936:Plant Extracts; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase