[Development of rapid-dissolution armillarisin-A tablet and study on its choleretic action in rats].
For increasing the choleretic action of armillarision-A, a new formulation of rapid-dissolution tablet (A) was developed. The effect of A, a marketed amillarisin-A tablet (B) and a armillarisin-A Na sterile power (C) on rats biliation in vivo were investigated. The dissolution rates of A and B were also determined. The results demonstrate that the choleretic action of A is equal to C but superior to B, and the dissolution rate of A is higher than B. Moreover, the armillarisin-A dissolved percentage of A in vitro at time t was well correlated with the biliation net accumulative amount in vivo at time 3t.
Zhu
J B
JB
Division of Pharmaceutics, China Pharmaceutical University, Nanjing.
Luan
L B
LB
Shi
Q C
QC
D000818:Animals; D001578:Benzopyrans / Q000008:administration & dosage* / Q000494:pharmacology; D001646:Bile / Q000378:metabolism*; D002756:Cholagogues and Choleretics / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D051381:Rats; D012995:Solubility; D013607:Tablets
D001578:Benzopyrans; D002756:Cholagogues and Choleretics; D013607:Tablets; C023435:armillarisin A