title: Significance of the clonal and sporadic chromosome abnormalities in non-neoplastic renal tissue.
abstract: Trisomy 7, trisomy 10 and loss of the Y chromosome have been found by some authors in presumptive normal parts of human kidneys. We describe cytogenetic findings in short-term cultures from 58 biopsies obtained from non-neoplastic and neoplastic (renal cell carcinoma, RCC) tissues from the same kidney, the same types of tissues from independent kidneys, and tissue from kidneys without neoplasia. The results indicate the following. Non-neoplastic tissue from kidneys involved in RCC have (in mosaics) trisomies 5, 7, 10, 18 and loss of the Y as non-random clonal changes. They are not the result of local metastasis but are also found in kidneys with non-tumoral chronic pathologies and should thus not be considered specific for RCC. They are neither culturing artefacts nor a general phenomenon found in cultured normal solid tissues, but are acquired abnormalities, possibly related to various reactive cellular states in the tissues that are histologically normal.
authors.affiliation: Biologia Generale e Genetica Medica, Università di Pavia, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Casalone
authors.forename: P
authors.initials: P
authors.lastname: Granata Casalone
authors.forename: E
authors.initials: E
authors.lastname: Minelli
authors.forename: P
authors.initials: P
authors.lastname: Portentoso
authors.forename: R
authors.initials: R
authors.lastname: Righi
authors.forename: E
authors.initials: E
authors.lastname: Meroni
authors.forename: A
authors.initials: A
authors.lastname: Giudici
authors.forename: D
authors.initials: D
authors.lastname: Donati
authors.forename: C
authors.initials: C
authors.lastname: Riva
authors.forename: S
authors.initials: S
authors.lastname: Salvatore
mesh_terms: D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000235:genetics*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002879:Chromosomes, Human, Pair 10; D002887:Chromosomes, Human, Pair 18; D002895:Chromosomes, Human, Pair 5; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007680:Kidney Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014314:Trisomy / Q000235:genetics; D014998:Y Chromosome