title: Hemorheological alterations in mild essential hypertension.
abstract: Blood rheological properties were studied in 21 patients suffering from essential hypertension (EHT), degree I-II according to WHO criteria. These patients were diagnosed "de novo". The whole blood filterability (WBF), blood viscosity (BV) at 230 s-1 and 23 s-1, red cell deformability (FI), erythrocyte aggregation in autologous (MEA) and normal plasma (MEAc), fibrinogen (Fbg) and hematocrit (Ht) have been evaluated. In the hypertensive patients we have found decreased WBF, greater BV and FI in comparison with the control group (p less than 0.001). Likewise, MEA and Fbg were increased, though the differences were less significant (p less than 0.01). The evaluation of Ht did not show any differences between the two groups. The results suggest that in the newly diagnosed EHT, clear hemorheological alterations occur, both in plasma and in the erythrocytes, which could play a role in the pathogenesis of the aforementioned disease.
authors.affiliation: Department of Clinical Pathology, Hospital La Fe, Valencia, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Vayá
authors.forename: M
authors.initials: M
authors.lastname: Martínez
authors.forename: J
authors.initials: J
authors.lastname: Garcia
authors.forename: M
authors.initials: M
authors.lastname: Labios
authors.forename: J
authors.initials: J
authors.lastname: Aznar
mesh_terms: D000328:Adult; D001772:Blood Cell Count; D001809:Blood Viscosity; D004903:Erythrocyte Aggregation; D004907:Erythrocyte Deformability; D004909:Erythrocyte Indices; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D006400:Hematocrit; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014655:Vascular Resistance
chemical_list: D005340:Fibrinogen