Pyrrylphenylethanones related to cathinone and lefetamine: synthesis and pharmacological activities.
The synthesis of various pyrrylphenylethanones resembling cathinone and lefetamine is described starting from 2-chloro-1-(1-methyl-1H-pyrrol-2-yl)-2-phenylethan-1-one. Some derivatives showed good antinociceptic activity, comparable to that of morphine. The neuropsychopharmacological profile of title compounds has been also studied to explore their action on C.N.S.
Massa
S
S
Dipartimento di Studi farmaceutici, Università di Roma, La Sapienza, Italy.
Di Santo
R
R
Mai
A
A
Artico
M
M
Pantaleoni
G C
GC
Giorgi
R
R
Coppolino
M F
MF
D000470:Alkaloids / Q000737:chemistry*; D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D005260:Female; D007659:Ketones / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D009125:Muscle Relaxants, Central / Q000138:chemical synthesis / Q000494:pharmacology; D010627:Phenethylamines / Q000737:chemistry*; D011619:Psychotropic Drugs / Q000138:chemical synthesis* / Q000494:pharmacology; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology
D000470:Alkaloids; D000700:Analgesics; D000927:Anticonvulsants; D007659:Ketones; D009125:Muscle Relaxants, Central; D010627:Phenethylamines; D011619:Psychotropic Drugs; D011758:Pyrroles; C011896:lephetamine; C023665:cathinone