Study of protein-drug binding using capillary zone electrophoresis.
CApillary zone electrophoresis was tested for its suitability for studying protein-drug binding. Three methods were investigated, viz., the Hummel-Dreyer method, the vacancy peak method and frontal analysis. Frontal analysis appeared to be the preferred method.
Kraak
J C
JC
Laboratory for Analytical Chemistry, University of Amsterdam, Netherlands.
Busch
S
S
Poppe
H
H
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D002417:Cattle; D004586:Electrophoresis; D006801:Humans; D007700:Kinetics; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011485:Protein Binding; D012710:Serum Albumin, Bovine / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet; D013816:Thermodynamics; D014859:Warfarin / Q000097:blood
D001798:Blood Proteins; D004364:Pharmaceutical Preparations; D012710:Serum Albumin, Bovine; D014859:Warfarin