Intrathecal midazolam versus intrathecal morphine in orofacial nociception: an experimental study in rats.
The antinociceptive properties of intrathecal midazolam (15 and 30 micrograms) and intrathecal morphine (30 micrograms) were compared using an adaptation of the formalin test to the orofacial region in rats. Both midazolam and morphine were effective in reducing the nociceptive response of the second phase of this biphasic pain test. Only midazolam (30 micrograms) reduced also the first phase. These results confirm the existence of analgesic properties of midazolam in the case of long-lasting pain.
Aigouy
L
L
Laboratoire de Physiologie Orofaciale, U.E.R. Odontologie, Clermont-Ferrand, France.
Fondras
J C
JC
Pajot
J
J
Schoeffler
P
P
Woda
A
A
D000818:Animals; D005157:Facial Pain / Q000139:chemically induced / Q000503:physiopathology; D005557:Formaldehyde; D007278:Injections, Spinal; D008297:Male; D008874:Midazolam / Q000008:administration & dosage / Q000494:pharmacology*; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D009055:Mouth; D009619:Nociceptors / Q000187:drug effects*; D010146:Pain / Q000139:chemically induced / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D005557:Formaldehyde; D009020:Morphine; D008874:Midazolam