title: [Fibronectins].
abstract: Fibronectins are complex glycoprotein macromolecules whose molecular weight is 440 kilodaltons. These proteins, found throughout the body, are soluble in biological fluids and insoluble in connective tissue. They contribute to tissue morphogenesis through multiple interactions with cells and extracellular matrix components. Fibronectins play a key role in cell attachment and remodeling during embryonic development, in cell migration and anchorage during wound healing, and in immune responses. This review discusses the structure of fibronectins, their integrin cell receptors, their biologic properties and their implications for diseases.
authors.affiliation: INSERM, Unité 209, Hôpital E. Herriot, Lyon, France.
authors.forename: C
authors.initials: C
authors.lastname: Stamm
authors.forename: Y
authors.initials: Y
authors.lastname: Sarret
authors.forename: D
authors.initials: D
authors.lastname: Schmitt
authors.forename: J
authors.initials: J
authors.lastname: Thivolet
mesh_terms: D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D005353:Fibronectins / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D016023:Integrins / Q000502:physiology*; D015603:Keratinocytes / Q000502:physiology; D014945:Wound Healing / Q000502:physiology
chemical_list: D005353:Fibronectins; D016023:Integrins
vernacular_title: Les fibronectines.