title: [Local anesthetics. 99. Synthesis and local anesthetic actions of alkoxyphenylcarbamates].
abstract: Within the framework of studying the influence of alterations of the connecting chain in the group of local anaesthetics a series of 24 compounds of 1-propoxymethyl-2-(1-pyrrolidinyl), 2-(1-piperidino)-, and 2-(1-perhydroazepinyl)-ethyl esters of o- and m-alkoxyphenylcarbamic acid were prepared. Studied compounds show a high index of relative local anaesthetic activity as compared to the standards cocaine and procaine, at a relatively low acute toxicity.
authors.affiliation: Lehrstuhl für Pharmazeutische Chemie der Pharmazeutischen Fakultät der Komensky-Universität, Bratislava, CSFR.
authors.forename: L
authors.initials: L
authors.lastname: Búciová
authors.forename: J
authors.initials: J
authors.lastname: Csöllei
authors.forename: E
authors.initials: E
authors.lastname: Racanská
authors.forename: P
authors.initials: P
authors.lastname: Svec
mesh_terms: D000779:Anesthetics, Local / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D002219:Carbamates / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051379:Mice
chemical_list: D000779:Anesthetics, Local; D002219:Carbamates
vernacular_title: Untersuchungen an Lokalanästhetika, 99.Mitt.: Synthese und lokalanästhetische Wirkung von Alkoxyphenylcarbamaten.