title: Malignant Leydig cell tumor of the testis in complete remission on o,p'-dichlorodiphenyl-dichloroethane.
abstract: A 56-year-old patient is described who presented with retroperitoneal lymph node metastases 2 years after resection of a Leydig cell tumor of the left testis. The patient did not suffer from endocrinological imbalance. Surgical removal of the metastases alleviated abdominal symptoms for 1 year. o,p'-Dichlorodiphenyl-dichloroethane (o,p'-DDD) treatment was started at the time of recurrence of the retroperitoneal mass and the appearance of a hepatic metastasis. Tumors were remarkably responsive to o,p'-DDD, since 2 complete remissions could be obtained for extended periods. The o,p'-DDD was tolerated reasonably well and serum levels of 15 to 20 mg./l. were sustained for many months. Unfortunately, the patient could not be cured with this effective treatment.
authors.affiliation: Department of Clinical Oncology, Free University Hospital, Amsterdam, The Netherlands.
authors.forename: K G
authors.initials: KG
authors.lastname: van der Hem
authors.forename: E
authors.initials: E
authors.lastname: Boven
authors.forename: M B
authors.initials: MB
authors.lastname: van Hennik
authors.forename: H M
authors.initials: HM
authors.lastname: Pinedo
mesh_terms: D006801:Humans; D007984:Leydig Cell Tumor / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D008939:Mitotane / Q000627:therapeutic use*; D012074:Remission Induction; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D008939:Mitotane