[Study on pilules of indomethacin--PEG 6000].
Indomethacin (IDM)-PEG 6000 pilules were prepared using PEG 6000 as the carrier. The solubility of IDM in IDM-PEG 6000 pilules was about twice as much as pure IDM. When the effective dose of IDM-PEG 6000 was only half that of IDM tablet, the irritation of IDM-PEG 6000 pilule on rat stomach was reduced significantly but it still manifested the action of inhibiting the secretion of basal gastric acid.
Lu
B
B
School of Pharmacy, West China University of Medical Sciences, Chengdu.
Lu
D
D
D000818:Animals; D004337:Drug Carriers; D005744:Gastric Acid / Q000378:metabolism; D007213:Indomethacin / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D008297:Male; D011092:Polyethylene Glycols; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced
D004337:Drug Carriers; D011092:Polyethylene Glycols; D007213:Indomethacin