Relationship between arterial and peripheral venous catecholamine plasma catecholamine concentrations during infusion of noradrenaline and adrenaline in healthy volunteers.
Noradrenaline and adrenaline were infused IV at 5 different rates (0.01-0.2 micrograms.kg.min-1) for 30 min to volunteers. The plasma catecholamine concentrations were determined by HPLC and electro-chemical detection. At the highest infusion rate, the arterial and venous plasma concentrations of noradrenaline increased from 1.18 to 44.1 nmol.l-1 and from 1.14 to 31.9 nmol.l-1, respectively, and of adrenaline from 0.29 to 23.9 nmol.l-1 and from 0.28 to 19.3 nmol.l-1, respectively. The peripheral venous plasma concentration of noradrenaline averaged 76% of the arterial concentration, and of adrenaline it was 73%. There was a linear relationship between the peripheral venous and arterial plasma noradrenaline and adrenaline concentrations at therapeutic doses.
Ensinger
H
H
Universitätsklinik für Anästhesiologie, Universität Ulm, FRG.
Weichel
T
T
Lindner
K H
KH
Prengel
A
A
Grünert
A
A
Ahnefeld
F W
FW
D000328:Adult; D001158:Arteries / Q000378:metabolism*; D002395:Catecholamines / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D004594:Electrophysiology; D004837:Epinephrine / Q000008:administration & dosage*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009638:Norepinephrine / Q000008:administration & dosage*; D014680:Veins / Q000378:metabolism*
D002395:Catecholamines; D009638:Norepinephrine; D004837:Epinephrine