title: Continuum of overlapping clones spanning the entire human chromosome 21q.
abstract: A continuous array of overlapping clones covering the entire human chromosome 21q was constructed from human yeast artificial chromosome libraries using sequence-tagged sites as landmarks specifically detected by polymerase chain reaction. The yeast artificial chromosome contiguous unit starts with pericentromeric and ends with subtelomeric loci of 21q. The resulting order of sequence-tagged sites is consistent with other physical and genetic mapping data. This set of overlapping clones will promote our knowledge of the structure of this chromosome and the function of its genes.
authors.affiliation: Centre d'Etude du Polymorphisme Humain (CEPH), Paris, France.
authors.forename: I
authors.initials: I
authors.lastname: Chumakov
authors.forename: P
authors.initials: P
authors.lastname: Rigault
authors.forename: S
authors.initials: S
authors.lastname: Guillou
authors.forename: P
authors.initials: P
authors.lastname: Ougen
authors.forename: A
authors.initials: A
authors.lastname: Billaut
authors.forename: G
authors.initials: G
authors.lastname: Guasconi
authors.forename: P
authors.initials: P
authors.lastname: Gervy
authors.forename: I
authors.initials: I
authors.lastname: LeGall
authors.forename: P
authors.initials: P
authors.lastname: Soularue
authors.forename: L
authors.initials: L
authors.lastname: Grinas
mesh_terms: D002874:Chromosome Mapping / Q000379:methods*; D015825:Chromosomes, Fungal; D002891:Chromosomes, Human, Pair 21; D003001:Cloning, Molecular; D015723:Gene Library; D005819:Genetic Markers; D015894:Genome, Human; D006801:Humans; D016133:Polymerase Chain Reaction; D016324:Sequence Tagged Sites
chemical_list: D005819:Genetic Markers