title: Homology-derived three-dimensional structure prediction of Candida cylindracea lipase.
abstract: We propose a structural model of Candida cylindracea lipase (CCL) based on the reported X-ray structure of the highly homologous Geotrichum candidum lipase (GCL). The network of interactions around the active site, the salt and disulfide bridge pattern is conserved in the proposed structure. Functional, structural and evolutionary aspects of the peculiar usage of CTG codons by C. cylindracea ATCC 14830 are discussed.
authors.affiliation: Dipartimento di Fisiologia e Biochimica Generali, Università degli Studi di Milano, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Longhi
authors.forename: M
authors.initials: M
authors.lastname: Lotti
authors.forename: F
authors.initials: F
authors.lastname: Fusetti
authors.forename: E
authors.initials: E
authors.lastname: Pizzi
authors.forename: A
authors.initials: A
authors.lastname: Tramontano
authors.forename: L
authors.initials: L
authors.lastname: Alberghina
mesh_terms: D005075:Biological Evolution; D002175:Candida / Q000201:enzymology*; D008049:Lipase / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D014961:X-Ray Diffraction
chemical_list: D008049:Lipase