title: The effect of endogenous nitric oxide on neurogenic plasma exudation in guinea-pig airways.
abstract: We studied the effect of endogenous nitric oxide (NO) on vagally induced plasma exudation into guinea-pig trachea and main bronchi using 125I-albumin as a plasma marker. NG-Nitro-L-arginine methyl ester (L-NAME, 1-10 mg/kg) dose dependently inhibited neurogenic plasma exudation. Intravenous phenylephrine which simulated the vasopressor effect as L-NAME (10 mg/kg) was without effect. The effect of L-NAME (5 mg/kg) was reversed by L-arginine (50 mg/kg). These results suggest that endogenous NO may contribute to neurogenic inflammation in the airways.
authors.affiliation: Department of Thoracic Medicine, National Heart and Lung Institute, London, UK.
authors.forename: H P
authors.initials: HP
authors.lastname: Kuo
authors.forename: S
authors.initials: S
authors.lastname: Liu
authors.forename: P J
authors.initials: PJ
authors.lastname: Barnes
mesh_terms: D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D001980:Bronchi / Q000378:metabolism*; D004558:Electric Stimulation; D006168:Guinea Pigs; D008297:Male; D019331:NG-Nitroarginine Methyl Ester; D009569:Nitric Oxide / Q000378:metabolism*; D010949:Plasma / Q000378:metabolism*; D014132:Trachea / Q000378:metabolism*; D014630:Vagus Nerve / Q000502:physiology*
chemical_list: D009569:Nitric Oxide; D001120:Arginine; D019331:NG-Nitroarginine Methyl Ester