Reveromycins, new inhibitors of eukaryotic cell growth. I. Producing organism, fermentation, isolation and physico-chemical properties.
New antibiotics named reveromycins A, B, C and D were isolated as inhibitors of mitogenic activity induced by epidermal growth factor (EGF) in a mouse epidermal keratinocyte. Reveromycins were produced by a soil actinomycete (strain SN-593) which belongs to the genus Streptomyces.
Takahashi
H
H
RIKEN, Institute of Physical and Chemical Research, Saitama, Japan.
Osada
H
H
Koshino
H
H
Kudo
T
T
Amano
S
S
Shimizu
S
S
Yoshihama
M
M
Isono
K
K
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D004815:Epidermal Growth Factor / Q000037:antagonists & inhibitors*; D051379:Mice; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D011714:Pyrans; D013141:Spiro Compounds; C068098:reveromycin A; D004815:Epidermal Growth Factor