title: [Mechanisms of the protective action of neoton in immune heart diseases].
abstract: An attempt was made to reveal some membrane mechanisms of the protective effect of phosphocreatine (Neoton produced by the Schiappare firm, injected intravenously in a dose of 500 mg/kg) predominantly on the endothelium of the coronary vessels and the cardiomyocytes. Local immune damage to the left-ventricular myocardium was produced by intracoronary injection of anticardiac antibodies. Morphological and biochemical studies showed damage to the membrane of endotheliocytes and cardiomyocytes: reduced activity of Na-Cametabolism and Na-, K-ATPase. The obtained data bore evidence of the protective effect of phosphocreatine in immune damage to the heart, which was realized on the level of the endotheliocyte and cardiomyocyte membranes.
authors.forename: A A
authors.initials: AA
authors.lastname: Moĭbenko
authors.forename: G I
authors.initials: GI
authors.lastname: Marchenko
authors.forename: L F
authors.initials: LF
authors.lastname: Popovich
authors.forename: G A
authors.initials: GA
authors.lastname: Cherednichenko
mesh_terms: D000818:Animals; D009202:Cardiomyopathies / Q000276:immunology / Q000517:prevention & control*; D004285:Dogs; D005260:Female; D008297:Male; D010725:Phosphocreatine / Q000494:pharmacology*
chemical_list: D010725:Phosphocreatine
vernacular_title: Mekhanizmy zashchitnogo deĭstviia neotona pri immunnom povrezhdenii serdtsa.