Bath-water compared with oral delivery of 8-methoxypsoralen PUVA therapy for chronic plaque psoriasis.
Forty-four patients with chronic plaque psoriasis were randomly allocated to treatment with bath-water-delivered 8-methoxypsoralen (bath 8-MOP) or oral 8-methoxypsoralen (oral 8-MOP) PUVA therapy. There was a significant reduction in extent of the lesions and psoriasis area and severity index (PASI) after 20 treatments with each modality. There was a fourfold reduction in cumulative ultraviolet A (UVA) dose in the bath group. Side-effects of erythema and nausea were less with bath therapy.
Collins
P
P
City of Dublin Skin and Cancer Hospital.
Rogers
S
S
D000284:Administration, Oral; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D001494:Baths; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008730:Methoxsalen / Q000008:administration & dosage*; D008875:Middle Aged; D011701:PUVA Therapy / Q000379:methods*; D011565:Psoriasis / Q000188:drug therapy*; D012720:Severity of Illness Index; D016037:Single-Blind Method
D008730:Methoxsalen