title: Sodium cotransport proteins.
abstract: Significant advances have been made in elucidating the structure of Na+ cotransport proteins. Some fifteen of these low-abundance proteins have been cloned, sequenced and functionally expressed. They are members of the 12 membrane-spanning superfamily and they segregate into two groups, the Na+/glucose (SGLT1) and Na+/Cl-/GABA (GAT-1) families. SGLT1 transporters are expressed in bacteria and animal cells, while GAT-1 transporters are mostly expressed in the brain. None have yet been found in plants.
authors.affiliation: University of California, Los Angeles.
authors.forename: E M
authors.initials: EM
authors.lastname: Wright
authors.forename: K M
authors.initials: KM
authors.lastname: Hager
authors.forename: E
authors.initials: E
authors.lastname: Turk
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics; D017433:Protein Structure, Secondary; D012964:Sodium / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D002712:Chlorides; D005680:gamma-Aminobutyric Acid; D012964:Sodium