The role of blocking factors and antipaternal lymphocytotoxic antibodies in the success of pregnancy in patients with recurrent spontaneous abortion.
OBJECTIVE
To elucidate the role of mixed lymphocyte reaction blocking factors (BF) and complement-dependent antipaternal lymphocytotoxic antibodies on the outcome of pregnancy in unexplained recurrent spontaneous aborters.


METHODS
A controlled study of immunotherapy in which the treated group was immunized with the husband's or a third party donor's lymphocytes and the control group received autologous lymphocytes.


METHODS
Tertiary care institution.


METHODS
Forty-three patients in the control group and 48 patients in the treated group.


METHODS
The before and after immunization levels of BF and antipaternal lymphocytotoxic antibodies were measured.


METHODS
The existence or changing pattern of BF and antipaternal lymphocytotoxic antibodies levels before and after immunization had no influence on the pregnancy outcome in either group of patients.


CONCLUSIONS
Neither BF nor antipaternal lymphocytotoxic antibodies is essential for successful pregnancy. They probably reflect the immunological response of the mother to exposure to fetal antigens.
Hwang
J L
JL
Department of Obstetrics and Gynecology, Medical College and Hospital National Taiwan University, Taipei, Republic of China.
Ho
H N
HN
Yang
Y S
YS
Hsieh
C Y
CY
Lee
T Y
TY
Gill
T J
TJ
D000026:Abortion, Habitual / Q000276:immunology* / Q000628:therapy*; D000951:Antigens, Neoplasm / Q000276:immunology*; D000961:Antilymphocyte Serum / Q000276:immunology*; D005220:Fathers; D005260:Female; D006801:Humans; D016219:Immunotherapy, Adoptive; D011247:Pregnancy / Q000706:statistics & numerical data
D000951:Antigens, Neoplasm; D000961:Antilymphocyte Serum; C020163:blocking factor