Polyamines as modulators of lipoperoxidation.
The polyamines spermine and spermidine and the diamine putrescine inhibit lipid peroxidation in phospholipid liposome suspensions and rat liver homogenates. Using the chemiluminescence technique the antioxidant activity of polyamines was found to be due to reactions with the free radical intermediates of lipid peroxidation and/or superoxide radicals. Also, the antioxidant action of polyamines correlated with the amount of their amino groups: the antioxidant activity increases from putrescine to spermine.
Pavlovic
D D
DD
Department of Biophysics, Med.-Biol. Institute, Sofia, Bulgaria.
Uzunova
P
P
Galabova
T
T
Peneva
V
V
Sokolova
Z
Z
Bjelakovic
G
G
Ribarov
S
S
D000818:Animals; D007501:Iron; D015227:Lipid Peroxidation / Q000187:drug effects*; D008081:Liposomes; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008163:Luminescent Measurements; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D010743:Phospholipids / Q000378:metabolism; D011073:Polyamines / Q000737:chemistry / Q000494:pharmacology*; D011700:Putrescine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013095:Spermidine / Q000494:pharmacology; D013096:Spermine / Q000494:pharmacology
D008081:Liposomes; D010743:Phospholipids; D011073:Polyamines; D013096:Spermine; D008315:Malondialdehyde; D007501:Iron; D013095:Spermidine; D011700:Putrescine