Trisomy 7 in nonneoplastic focal steatosis of the liver.
Cytogenetic analysis of short-term cultures of a nonneoplastic focal steatosis of the liver showed trisomy 7 as the sole chromosomal change. This finding, especially when viewed in light of previous reports describing +7 in nonneoplastic tissues, strongly suggests that trisomy 7 cannot be considered a tumor-specific abnormality when it occurs as the only change. The cell type in which +7 is present is not yet known.
Bardi
G
G
Department of Clinical Genetics, Lund University Hospital, Sweden.
Johansson
B
B
Pandis
N
N
Heim
S
S
Mandahl
N
N
Hägerstrand
I
I
Holmin
T
T
Andrén-Sandberg
A
A
Mitelman
F
F
D000328:Adult; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology / Q000648:ultrastructure; D008107:Liver Diseases / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014314:Trisomy