Antitumor-promoting activities of tannic acid, ellagic acid, and several gallic acid derivatives in mouse skin.
Naturally occurring plant phenols with antimutagenic and anticarcinogenic activities were tested for their abilities to inhibit the biochemical and biological effects of the potent tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in mouse epidermis in vivo. When applied topically to mouse skin, tannic acid (TA), ellagic acid, and several gallic acid derivatives all inhibit TPA-induced ornithine decarboxylase activity, hydroperoxide production, and DNA synthesis, three biochemical markers of skin tumor promotion. Moreover, in the two-step initiation-promotion protocol, the same phenolic compounds also inhibit the incidence and yield of skin tumors promoted by TPA. TA is the most effective of these treatments. Since they are already known to inhibit tumor initiation, the plant phenols protecting against skin tumor promotion by TPA may be universal inhibitors of multistage carcinogenesis. TA and other polyphenols, therefore, might be valuable in cancer therapy and/or prevention.
Perchellet
J P
JP
Anti-Cancer Drug Laboratory, Kansas State University, Manhattan 66506-4901.
Gali
H U
HU
Perchellet
E M
EM
Klish
D S
DS
Armbrust
A D
AD
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004610:Ellagic Acid / Q000494:pharmacology*; D005707:Gallic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*; D006861:Hydrogen Peroxide / Q000378:metabolism; D047348:Hydrolyzable Tannins / Q000494:pharmacology*; D051379:Mice; D065108:Ornithine Decarboxylase Inhibitors; D012878:Skin Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D013755:Tetradecanoylphorbol Acetate
D000972:Antineoplastic Agents, Phytogenic; D047348:Hydrolyzable Tannins; D065108:Ornithine Decarboxylase Inhibitors; D004610:Ellagic Acid; D005707:Gallic Acid; D004247:DNA; D006861:Hydrogen Peroxide; D013755:Tetradecanoylphorbol Acetate