7,8-Dihydro-8-ethyl-2-(3-noradamantyl)-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one: a potent and water-soluble adenosine A1 antagonist.
Suzuki
F
F
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Shizuoka-ken, Japan.
Shimada
J
J
Nonaka
H
H
Ishii
A
A
Shiozaki
S
S
Ichikawa
S
S
Ono
E
E
D000218:Adamantane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology; D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology; D019830:Adenosine-5'-(N-ethylcarboxamide); D000818:Animals; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D058914:Purinergic Antagonists; D011688:Purinones / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D011983:Receptors, Purinergic / Q000378:metabolism; D012995:Solubility; D014665:Vasodilator Agents / Q000494:pharmacology
D007093:Imidazoles; D058914:Purinergic Antagonists; D011688:Purinones; D011983:Receptors, Purinergic; D014665:Vasodilator Agents; C076920:KF 20274; D019830:Adenosine-5'-(N-ethylcarboxamide); D000241:Adenosine; D000218:Adamantane