N,O-diacylated-N-hydroxyarylsulfonamides: nitroxyl precursors with potent smooth muscle relaxant properties.
N,O-Diacylated-N-hydroxyarylsulfonamides are capable of slowly releasing nitroxyl (HNO) by simple, non-enzymatic hydrolysis in Krebs solution at 37 degrees C. Release of nitric oxide (NO) was not seen. These compounds were also found to elicit vasorelaxation in rabbit thoracic aorta in vitro, presumably as a result of their ability to release HNO. This effect was enhanced by the addition of superoxide dismutase (SOD). Thus, these results are consistent with previous work indicating that HNO is a potent vasorelaxant.
Fukuto
J M
JM
Department of Pharmacology, UCLA School of Medicine 90024.
Hszieh
R
R
Gulati
P
P
Chiang
K T
KT
Nagasawa
H T
HT
D000818:Animals; D066298:In Vitro Techniques; D009130:Muscle, Smooth / Q000187:drug effects*; D009589:Nitrogen Oxides / Q000737:chemistry*; D011355:Prodrugs / Q000737:chemistry; D011817:Rabbits; D013449:Sulfonamides / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000494:pharmacology; D014665:Vasodilator Agents / Q000737:chemistry / Q000494:pharmacology*
D009589:Nitrogen Oxides; D011355:Prodrugs; D013449:Sulfonamides; D014665:Vasodilator Agents; D013482:Superoxide Dismutase; C039900:nitroxyl