Humoral CSF parameters in the differential diagnosis of hematologic CNS neoplasia.
Cerebrospinal fluid (CSF) and serum samples of 20 patients with central nervous system manifestations of hematological malignancies including primary cerebral lymphoma (n = 5) and disseminated non-Hodgkin lymphoma (n = 7) were examined for albumin, IgG, IgM, fibronectin, beta 2-microglobulin, interleukin-6, soluble interleukin-2 receptor, tumor necrosis factor alpha, and oligoclonal immunoglobulin bands. Although a broad range of abnormalities were detected, no reliable CSF parameter for the diagnosis of leptomeningeal spread from hematological neoplasias could be identified. An analysis of 61 repeat lumbar punctures added little to the findings of the first CSF examinations. Currently, immunochemical studies of CSF cell surface markers and early biopsy have probably more clinical value than the determination of the humoral CSF parameters included in this study. However, analysis of cytokine synthesis by single CSF cells using molecular biology techniques may improve the differential diagnosis of hematological neoplasia of the brain and spinal cord in the future.
Weller
M
M
Department of Neurology, University of Tübingen, Germany.
Stevens
A
A
Sommer
N
N
Schabet
M
M
Wiethölter
H
H
D014408:Biomarkers, Tumor / Q000134:cerebrospinal fluid*; D001812:Blood-Brain Barrier / Q000502:physiology; D002555:Cerebrospinal Fluid / Q000166:cytology; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D007075:Immunoglobulin M / Q000134:cerebrospinal fluid; D015850:Interleukin-6 / Q000134:cerebrospinal fluid; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000276:immunology; D017254:Leukemic Infiltration; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000276:immunology; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000276:immunology; D008578:Meninges / Q000473:pathology; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000276:immunology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000276:immunology; D015375:Receptors, Interleukin-2 / Q000032:analysis; D012709:Serum Albumin / Q000134:cerebrospinal fluid; D014409:Tumor Necrosis Factor-alpha / Q000134:cerebrospinal fluid; D001613:beta 2-Microglobulin / Q000134:cerebrospinal fluid
D014408:Biomarkers, Tumor; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015850:Interleukin-6; D015375:Receptors, Interleukin-2; D012709:Serum Albumin; D014409:Tumor Necrosis Factor-alpha; D001613:beta 2-Microglobulin