Tissue-specific localization of mitochondrial imidazoline-guanidinium receptive sites.
In the present report, we studied the distribution of the imidazoline-guanidinium receptive site in mitochondrial fractions from different rabbit and human tissues. Binding studies of the imidazoline-guanidinium receptive site ligand [3H]idazoxan, allowed to distinguish two groups of tissues: the first one, including kidney, brain and liver, displays a high density of imidazoline-guanidinium receptive site; the second one, consisting of striated and smooth muscle, enterocytes, lung, spleen and heart, is characterized by 4- to 16-fold lower binding site density. The demonstration that mitochondrial imidazoline-guanidinium receptive sites are not equally expressed in all tissues can be considered as a further progress towards the characterization of their functional activity.
Tesson
F
F
C.N.R.S. URA 1482, Laboratoire de Pharmacologie, CHU Necker, Paris, France.
Limon
I
I
Parini
A
A
D000818:Animals; D001665:Binding Sites; D004146:Dioxanes / Q000378:metabolism*; D006801:Humans; D019329:Idazoxan; D054755:Imidazoline Receptors; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D011817:Rabbits; D011955:Receptors, Drug / Q000378:metabolism*; D015016:Yohimbine / Q000494:pharmacology
D004146:Dioxanes; D054755:Imidazoline Receptors; D011955:Receptors, Drug; D015016:Yohimbine; D019329:Idazoxan