title: Hypersensitivity and anaphylactoid reactions to ciprofloxacin.
abstract: OBJECTIVE
  To report three cases of life-threatening hypersensitivity reactions to the oral administration of ciprofloxacin.
  
  
  METHODS
  Life-threatening hypersensitivity reactions to oral ciprofloxacin, characterized by diffuse, erythematous, nonpruritic, blanching rash, with fever and hypotension, occurred in two HIV-infected patients. One of these reactions was considered anaphylactoid. A similar hypersensitivity reaction was documented in a non-HIV-infected patient.
  
  
  CONCLUSIONS
  Premarketing clinical trials described no reports of life-threatening anaphylactoid hypersensitivity reactions to ciprofloxacin. However, postmarketing surveillance studies have documented their occurrence. Seven cases of anaphylactoid reaction to ciprofloxacin have now been documented in HIV-infected patients.
  
  
  CONCLUSIONS
  As with trimethoprim/sulfamethoxazole, HIV-infected people treated with ciprofloxacin may be at special risk for hypersensitivity reactions.
authors.affiliation: Ventura County Medical Center, Office of Medical Education, CA 93003.
authors.forename: R L
authors.initials: RL
authors.lastname: Deamer
authors.forename: J G
authors.initials: JG
authors.lastname: Prichard
authors.forename: G J
authors.initials: GJ
authors.lastname: Loman
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000284:Administration, Oral; D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D002939:Ciprofloxacin