title: The presence of specific IgE to salicyloyl and O-methylsalicyloyl in aspirin-sensitive patients.
abstract: Certain adverse reactions to aspirin (ASA), nonsteroidal anti-inflammatory drugs (NSAIDs) and pyrazoline derivatives resemble IgE-mediated hypersensitivity. However, convincing evidence of antigen-antibody interactions or of the inhibition of the cyclooxygenase pathway of arachidonic acid metabolism leading to an increase in the generation of leukotrienes (LTs) and a decrease in the generation of prostaglandins (PGs) was not fully demonstrated. In this study, two types of specific IgE antibodies have been found in 27 serum samples from 28 ASA-sensitive patients with salicyloyl-discs and O-methylsalicyloyl-discs by Radio Allergo Sorbent Tests (RAST). The positive rates were 96.4% and 71.4%, respectively. In contrast, no positive results could be found in 10 normal donors without ASA sensitivity after ingestion of ASA 500 mg/day for 14 days. Further investigation of the chemical structure of epitopes was done by cross inhibition studies. Our results are an increasing evidence in favour of an IgE-dependent mechanism in patients suffering from ASA sensitivity. Hopefully, the determination of specific IgE antibodies will be a safe diagnostic method of ASA sensitivity in vitro.
authors.affiliation: Department of Allergy, Xuan-Wu Hospital, Beijing, China.
authors.forename: D
authors.initials: D
authors.lastname: Zhu
authors.forename: W M
authors.initials: WM
authors.lastname: Becker
authors.forename: K H
authors.initials: KH
authors.lastname: Schulz
authors.forename: K
authors.initials: K
authors.lastname: Schubeler
authors.forename: M
authors.initials: M
authors.lastname: Schlaak
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001241:Aspirin / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000276:immunology*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011852:Radioallergosorbent Test / Q000379:methods; D012459:Salicylates / Q000276:immunology*; D020156:Salicylic Acid
chemical_list: D012459:Salicylates; D007073:Immunoglobulin E; C033069:methyl salicylate; D020156:Salicylic Acid; D001241:Aspirin