title: Changing trends in the indications for penetrating keratoplasty.
abstract: The indications for penetrating keratoplasty have changed over the past several years. Nine hundred ninety-nine penetrating keratoplasty specimens from 1981 through 1990 were analyzed. Overall, keratoconus was the most common indication for penetrating keratoplasty (24.2%). This was followed by pseudophakic bullous keratopathy (23.0%), regraft (13.1%), scarring (8.2%), and Fuchs' endothelial dystrophy (5.8%). Pseudophakic bullous keratopathy was the most common indication for penetrating keratoplasty in each year from 1984 through 1989 with a peak in 1987 (33%). Since 1987, the number of pseudophakic bullous keratopathy cases has decreased; and in 1990, keratoconus (33.1%) surpassed pseudophakic bullous keratopathy (24.1%) as the most common indication for penetrating keratoplasty. This decreasing incidence of pseudophakic bullous keratopathy may reflect the discontinued use of closed-looped anterior chamber and iris-plane intraocular lenses most commonly associated with this complication.
authors.affiliation: Intermountain Ocular Research Center, University of Utah School of Medicine, Salt Lake City.
authors.forename: N
authors.initials: N
authors.lastname: Mamalis
authors.forename: C W
authors.initials: CW
authors.lastname: Anderson
authors.forename: K R
authors.initials: KR
authors.lastname: Kreisler
authors.forename: M K
authors.initials: MK
authors.lastname: Lundergan
authors.forename: R J
authors.initials: RJ
authors.lastname: Olson
mesh_terms: D002387:Cataract Extraction; D003316:Corneal Diseases / Q000453:epidemiology / Q000601:surgery*; D006801:Humans; D015994:Incidence; D015948:Keratoplasty, Penetrating / Q000639:trends*; D007910:Lenses, Intraocular; D014589:Utah / Q000453:epidemiology