Fosfomycin enhances the expression of penicillin-binding protein 2 in methicillin-sensitive and methicillin-resistant Staphylococcus aureus strains.
The effects of fosfomycin on penicillin-binding proteins (PBPs) were studied on the methicillin-resistant Staphylococcus aureus strain CIP (Collection de l'Institut Pasteur, Paris, France) 65-25 and on a methicillin-susceptible S. aureus strain CIP 65-6. The combinations of fosfomycin and oxacillin were synergistic, additive or antagonistic, depending on antibiotic concentrations. Fosfomycin induced modifications of the PBP profile of the two strains studied. In particular, it increased the expression of PBP2. This suggested that this protein is inducible; the only PBP not affected by fosfomycin was PBP3.
Najioullah
F
F
Laboratoire Central de Microbiologie, Hôpital Edouard Herriot, Lyon, France.
Pellon
G
G
Freney
J
J
Michel
G
G
Fleurette
J
J
D001426:Bacterial Proteins; D002352:Carrier Proteins; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000494:pharmacology; D005578:Fosfomycin / Q000494:pharmacology*; D006602:Hexosyltransferases / Q000737:chemistry / Q000187:drug effects*; D016106:Methicillin Resistance; D009097:Multienzyme Complexes / Q000737:chemistry / Q000187:drug effects*; D002267:Muramoylpentapeptide Carboxypeptidase; D010068:Oxacillin / Q000494:pharmacology*; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases / Q000737:chemistry / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects*
D001426:Bacterial Proteins; D002352:Carrier Proteins; D009097:Multienzyme Complexes; D046915:Penicillin-Binding Proteins; D005578:Fosfomycin; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase; D010068:Oxacillin