title: The relationship between a nutritional index and acute physiology score in critical illness.
abstract: Prognostic indices derived from available physiological data (SAPS), complex nutritional and biochemical tests (PNI), grip strength and serum albumin were calculated in 16 critically ill patients receiving intravenous nutrition over a six week period. The aim was to compare these independently derived prognostic indices, to assess their response to feeding, and to determine suitability for use in Irish intensive care units. Mean SAPS (7.6 +/- 0.92), PNI (3.1 +/- 0.29), serum albumin (30.3 +/- 1.03 g/l) and grip strength (17.9 +/- 1.3%) were all suggestive of an "at risk" group. Significant associations were found between the accepted SAPS index and both PNI (r = 0.6, p < 0.001, n = 35) and grip strength (r = -0.68, p < 0.001, n = 44) but not with serum albumin. No consistent improvement was seen in response to feeding in any of the derived indices. The close correlation between prognostic indices derived from either physiological, nutritional or grip strength data in this study and the failure of prognostic indices to improve during hyperalimentation would support a common mechanism, e.g. endogenous mediators, for metabolic and physiological disturbance in critical illness. It suggests that the role of hyperalimentation is supportive rather than therapeutic and re-iterates the importance of managing underlying disease processes. Simple grip strength may be a useful alternative to complex nutritional indices.
authors.affiliation: Surgical Professorial Unit, University College Dublin.
authors.forename: D B
authors.initials: DB
authors.lastname: Gough
authors.forename: M
authors.initials: M
authors.lastname: White
authors.forename: M
authors.initials: M
authors.lastname: Morrin
authors.forename: W
authors.initials: W
authors.lastname: Joyce
authors.forename: D
authors.initials: D
authors.lastname: Phelan
authors.forename: J M
authors.initials: JM
authors.lastname: Fitzpatrick
authors.forename: T F
authors.initials: TF
authors.lastname: Gorey
mesh_terms: D016638:Critical Illness / Q000628:therapy*; D006801:Humans; D015596:Nutrition Assessment; D010289:Parenteral Nutrition, Total; D011379:Prognosis; D012720:Severity of Illness Index