Optic nerve transection decreases 2-[125I]iodomelatonin binding in the chick optic tectum.
The distribution of specific 2-[125I]iodomelatonin binding sites in the various layers of the chick optic tectum was analyzed using quantitative receptor autoradiography. Following unilateral optic nerve transection, binding in the optic fiber layer and superficial retinorecipient layers of the contralateral tectum was significantly decreased at 7 and 14 days, but not at 1 day, following transection. The results are consistent with the presence of presynaptic melatonin receptors on axon terminals of retinotectal fibers.
Krause
D N
DN
Department of Pharmacology, College of Medicine, University of California, Irvine 92717.
Siuciak
J A
JA
Dubocovich
M L
ML
D000818:Animals; D001345:Autoradiography; D002645:Chickens; D007457:Iodine Radioisotopes; D008550:Melatonin / Q000031:analogs & derivatives* / Q000378:metabolism; D009900:Optic Nerve / Q000502:physiology*; D013477:Superior Colliculi / Q000378:metabolism*
D007457:Iodine Radioisotopes; C044556:2-iodomelatonin; D008550:Melatonin