title: The baboon model under anesthesia for in vivo cerebral blood flow studies using single photon emission computed tomographic (SPECT) techniques.
abstract: Single photon emission computed tomography of the brain can be useful in animal experimentation directed toward cerebral conditions. A well established and understood baboon model, necessarily under anesthesia, could be especially valuable in such investigations. Six normal baboons were studied under various anesthetic agents and their combinations: ketamine, thiopentone, pentobarbitone, and halothane. Cerebral blood flow (CBF) studies were performed with 99mTc-HMPAO. CBF effects from various anesthesia were detected, requiring careful choice of the anesthesia for cerebral investigations.
authors.affiliation: AEC Institute for Life Sciences, University of Pretoria, South Africa.
authors.forename: I
authors.initials: I
authors.lastname: Dormehl
authors.forename: F
authors.initials: F
authors.lastname: Redelinghuys
authors.forename: N
authors.initials: N
authors.lastname: Hugo
authors.forename: D
authors.initials: D
authors.lastname: Oliver
authors.forename: W
authors.initials: W
authors.lastname: Pilloy
mesh_terms: D000758:Anesthesia / Q000662:veterinary; D000777:Anesthetics; D000818:Animals; D002560:Cerebrovascular Circulation / Q000502:physiology*; D008297:Male; D008955:Models, Cardiovascular; D010215:Papio / Q000502:physiology*; D015899:Tomography, Emission-Computed, Single-Photon / Q000662:veterinary*
chemical_list: D000777:Anesthetics