Some forms of tinnitus may involve the extralemniscal auditory pathway.
It has previously been shown that the click-evoked responses recorded from the intracranial portion of the eighth nerve in patients with incapacitating tinnitus are not abnormal, nor is the latency of peak III of the click-evoked brainstem auditory-evoked potentials significantly altered; however, the latency of peak V is slightly (but significantly) shortened in comparison to that of patients with the same degree of hearing loss but no tinnitus. In this study the hypothesis that the extralemniscal auditory system is involved in the generation of tinnitus is tested. We made use of the fact that neurons of the extralemniscal auditory system also receive input from the somatosensory system, and that stimulation of the somatosensory system can influence the processing of auditory information in the extralemniscal system. In 4 of 26 patients with mild-to-severe tinnitus whose median nerve was stimulated electrically, the tinnitus increased noticeably during stimulation, in 6 the intensity of the tinnitus decreased noticeably, and in the remaining 16 there was no noticeable change in the tinnitus. In some of the patients the character of the tinnitus changed in a complex way. There were no significant differences in hearing thresholds in these three groups of patients. Electrical stimulation of the median nerve in 12 individuals with normal hearing who did not have tinnitus either had no effect on the loudness of sounds or it caused a slight increase in the loudness.
Møller
A R
AR
Department of Neurological Surgery, University of Pittsburgh School of Medicine, PA.
Møller
M B
MB
Yokota
M
M
D001306:Auditory Pathways / Q000502:physiology*; D004558:Electric Stimulation; D016057:Evoked Potentials, Auditory, Brain Stem; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D006801:Humans; D008144:Loudness Perception / Q000502:physiology; D008297:Male; D008475:Median Nerve / Q000502:physiology*; D009408:Nerve Compression Syndromes / Q000150:complications / Q000601:surgery; D014012:Tinnitus / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D000159:Vestibulocochlear Nerve / Q000502:physiology