title: Bone cell interactions with a granular glass-ionomer bone substitute material: in vivo and in vitro culture models.
abstract: The interface between bone and a synthetic bone substitute constructed from glass-ionomer cement (ionomeric microimplant) was studied in diffusion chambers implanted in a primate baboon model (Papio ursinus) and in in vitro primary bone organ cultures derived from neonate rat calvaria. In both models osteoblast-like cells colonized the surface of the implant producing a collagenous extracellular matrix. An electron-dense bonding zone similar to that reported for hydroxyapatite and titanium was seen in both models but was a more constant feature of the tissue/implant interface in calvarial culture.
authors.affiliation: University of Sheffield, School of Clinical Dentistry, UK.
authors.forename: I M
authors.initials: IM
authors.lastname: Brook
authors.forename: G T
authors.initials: GT
authors.lastname: Craig
authors.forename: P V
authors.initials: PV
authors.lastname: Hatton
authors.forename: L M
authors.initials: LM
authors.lastname: Jonck
mesh_terms: D000818:Animals; D001843:Bone Cements / Q000494:pharmacology*; D001842:Bone and Bones / Q000166:cytology / Q000187:drug effects*; D002478:Cells, Cultured; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D008954:Models, Biological; D009924:Organ Culture Techniques; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects; D010215:Papio; D019736:Prostheses and Implants; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001843:Bone Cements