title: [The effect of bovine surfactant in premature infants with respiratory distress syndrome. Results of an open, multicenter study].
abstract: We investigated the effects of a bovine surfactant (SF-RI 1, Alveofact) in very low birth weight infants (VLBW, b.w. 500-1500 g) with established respiratory distress syndrome (RDS; definition: FiO2 greater than or equal to 0.6 or peak inspiratory pressure greater than 22-28 cm H2O). Fifty mg/kg b.w. bovine surfactant was administered intratracheally as a bolus, if the acute response was unsatisfactory (FiO2 greater than 0.5), further administrations of surfactant up to a maximum cumulative dose of 200 mg/kg b.w. were permitted. One hundred and sixty-four VLBW infants (gestational age 28.0 +/- 2 wks; b.w. 1054 +/- 251 g; mean +/- SD) with a mean FiO2 of 0.84 +/- 0.15 were enrolled in the study. Maximum improvement in oxygen requirements was observed 1/2 h post administration (FiO2 0.53 +/- 0.22); incidence of complications during the neonatal period: pulmonary interstitial emphysema 26%, pneumothorax 10%, patent ductus arteriosus 37%, intracranial hemorrhage 47%. The overall survival rate was 61%, survival rate without bronchopulmonary dysplasia (BPD) was 47%. A multiple regression analysis was performed in order to identity factors determining survival without BPD (p less than or equal to 0.05). We observed a positive correlation for gestational age and birth weight and a negative correlation for pretreatment oxygen requirements. For further optimizing surfactant-therapy in VLBW infants with RDS, studies are mandatory using intervention criteria at lower FiO2-values and higher initial doses of bovine surfactant.
authors.affiliation: Universitätskinderklinik Ulm.
authors.forename: L
authors.initials: L
authors.lastname: Gortner
authors.forename: P
authors.initials: P
authors.lastname: Bartmann
authors.forename: U
authors.initials: U
authors.lastname: Bernsau
authors.forename: H H
authors.initials: HH
authors.lastname: Hellwege
authors.forename: G
authors.initials: G
authors.lastname: Hieronimi
authors.forename: G
authors.initials: G
authors.lastname: Jorch
authors.forename: H L
authors.initials: HL
authors.lastname: Reiter
authors.forename: H
authors.initials: H
authors.lastname: Versmold
mesh_terms: D006801:Humans; D007231:Infant, Newborn; D010100:Oxygen / Q000097:blood; D011175:Positive-Pressure Respiration; D011446:Prospective Studies; D011659:Pulmonary Gas Exchange / Q000502:physiology; D011663:Pulmonary Surfactants / Q000008:administration & dosage*; D012121:Respiration, Artificial; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood / Q000401:mortality / Q000628:therapy*; D015996:Survival Rate
chemical_list: D011663:Pulmonary Surfactants; D010100:Oxygen
vernacular_title: Die Wirkung eines bovinen Surfactant bei Frühgeborenen mit Atemnotsyndrom. Daten einer offenen, multizentrischen Studie.