Pharmacokinetics and metabolism of [3H]-pipethiaden in healthy volunteers.
Six healthy volunteers participated in a single-dose study of pharmacokinetics and metabolism of oral administration of [3H]-pipethiaden (1 mg). Plasma levels of total radioactivity, urinary excretion and metabolism were analyzed by liquid scintillation counting and radio-TLC. The mean peak plasma concentration of radioactive metabolites was 4.9 ng eq/ml, and the mean elimination half life was 11.5 h. 34% of radioactivity was recovered in 4 days in urine, with only 0.4% present as unchanged drug. Pipethiaden was extensively metabolized by S-oxidation, N-demethylation, and N-oxidation.
Plecitá
Z
Z
Research Institute for Pharmacy and Biochemistry, Prague, Czechoslovakia.
Spanĕl
M
M
Ulc
I
I
Rejŏlec
V
V
Lapka
R
R
D000328:Adult; D006801:Humans; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000493:pharmacokinetics*; D014316:Tritium
D010880:Piperidines; D014316:Tritium; C045300:pipethiaden