title: Role of foods in the pathogenesis of chronic paronychia.
abstract: BACKGROUND
  Chronic paronychia is a condition that is pathologically characterized by spongiotic inflammation; it can be exacerbated by various and concomitant factors.
  
  
  OBJECTIVE
  The aim of this study was to assess whether chronic paronychia in food handlers may have clinical, pathologic, and immunohistochemical similarities with immediate contact dermatitis caused by foods.
  
  
  METHODS
  Twenty food handlers affected by chronic paronychia were submitted to patch tests with the fresh foods that were suspected of being the cause of the dermatitis.
  
  
  RESULTS
  Nine patients had a positive reaction to a 20-minute open patch test with fresh foods applied on the proximal nailfold. In two patients the pathologic study of the positive open patch test site showed acanthosis, exocytosis, and spongiosis of the epidermis and the presence of an inflammatory lymphocytic infiltrate in the dermis.
  
  
  CONCLUSIONS
  Our results confirm the view that an immediate hypersensitivity reaction to foods can be responsible for some cases of chronic paronychia in food handlers.
authors.affiliation: Department of Dermatology, University of Bologna, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Tosti
authors.forename: L
authors.initials: L
authors.lastname: Guerra
authors.forename: R
authors.initials: R
authors.lastname: Morelli
authors.forename: F
authors.initials: F
authors.lastname: Bardazzi
authors.forename: P A
authors.initials: PA
authors.lastname: Fanti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D017449:Dermatitis, Allergic Contact / Q000473:pathology; D009783:Dermatitis, Occupational / Q000473:pathology; D005260:Female; D005385:Fingers; D005511:Food Handling; D006801:Humans; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D010304:Paronychia / Q000209:etiology* / Q000276:immunology / Q000473:pathology