An immunoelectron-microscopical observation of mouse juxtaglomerular cells in the case of experimental hydronephrosis.
Changes in juxtaglomerular (JG; renin-containing) cells in experimental hydronephrosis 1 month after ureteral ligation were investigated with immunoelectron-microscopical techniques. Two types of granules, electron dense (D) and lucent (L), were observed. D type granules were labeled more intensely with gold particles than those of L type. Granules intermediate between D and L types and exocytosis of D types were observed. In the cells containing D types exclusively, gold particles were restricted to the granules, whereas in the cells containing both D and L type granules, the particles were scattered throughout the cytoplasmic cytosol. The authors discuss the mechanisms of renin release in JG cells.
Kon
Y
Y
Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Hashimoto
Y
Y
Murakami
K
K
Sugimura
M
M
D000818:Animals; D005260:Female; D006869:Hydronephrosis / Q000378:metabolism*; D007150:Immunohistochemistry; D007606:Juxtaglomerular Apparatus / Q000737:chemistry* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D016253:Microscopy, Immunoelectron; D012083:Renin / Q000032:analysis* / Q000378:metabolism
D012083:Renin