Characterization of group specific antibodies in primates: studies with SIV envelope in macaques.
Sera from SIV-infected macaques were found to contain antibodies that reacted with conformation-dependent, group-specific determinants on the SIV envelope protein gp130. These conformation-dependent antibodies exhibited virus neutralizing activity; their presence was associated with protection in vaccine studies. The properties of these antibodies are quite similar to those that have been identified in sera from HIV-infected human subjects. These data suggest that the SIV envelope gp130 remains a candidate for subunit vaccine studies.
Haigwood
N L
NL
Chiron Corporation, Emeryville, CA 94608.
Misher
L
L
Chin
S M
SM
Blair
M
M
Planelles
V
V
Scandella
C J
CJ
Steimer
K S
KS
Gardner
M B
MB
Yilma
T
T
Hirsch
V M
VM
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D015153:Blotting, Western; D016466:CHO Cells; D006224:Cricetinae; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D015497:HIV-1 / Q000276:immunology; D007106:Immune Sera / Q000276:immunology; D008251:Macaca; D009500:Neutralization Tests; D015531:Radioimmunoprecipitation Assay; D011994:Recombinant Proteins / Q000276:immunology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D015164:Vaccines, Inactivated / Q000276:immunology; D014759:Viral Envelope Proteins / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology
D000914:Antibodies, Viral; D007106:Immune Sera; D011994:Recombinant Proteins; D015164:Vaccines, Inactivated; D014759:Viral Envelope Proteins; D014765:Viral Vaccines