Immunotoxins: the power and the glory.
Immunotoxins are hybrid proteins in which the potent cytocidal action of a toxin is harnessed for the selective destruction of target cells by attachment to a specific monoclonal antibody (mAb) or growth factor. This brief article describes the latest advances in the molecular and cellular biology, pharmacology and clinical evaluation of immunotoxins, as discussed at a recent meeting.
Wawrzynczak
E J
EJ
Institute of Cancer Research, Sutton, Surrey, UK.
Derbyshire
E J
EJ
D000818:Animals; D000911:Antibodies, Monoclonal; D006086:Graft vs Host Disease / Q000628:therapy; D006801:Humans; D000922:Immunotoxins / Q000276:immunology / Q000627:therapeutic use; D016393:Lymphoma, B-Cell / Q000628:therapy
D000911:Antibodies, Monoclonal; D000922:Immunotoxins