Reveromycins, new inhibitors of eukaryotic cell growth. III. Structures of reveromycins A, B, C and D.
Reveromycins A, B, C and D are new group inhibitors of the mitogenic activity of epidermal growth factor (EGF), produced by Streptomyces sp. Reveromycins are novel polyketide type antibiotics which have two terminal carboxylic groups, a spiroketal, a succinate and a varied side chain in the molecule. Determination of their structures by chemical and spectroscopic methods, in particular NMR studies, is described.
Koshino
H
H
RIKEN, Institute of Physical and Chemical Research, Saitama, Japan.
Takahashi
H
H
Osada
H
H
Isono
K
K
D000107:Acetylation; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004815:Epidermal Growth Factor / Q000037:antagonists & inhibitors*; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D011714:Pyrans / Q000737:chemistry*; D013141:Spiro Compounds / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D011714:Pyrans; D013141:Spiro Compounds; C068098:reveromycin A; D004815:Epidermal Growth Factor