Lactimidomycin, a new glutarimide group antibiotic. Production, isolation, structure and biological activity.
Streptomyces amphibiosporus R310-104 (ATCC 53964) produced a novel antibiotic lactimidomycin which showed inhibitory activity against fungi and prolonged the survival time of mice transplanted with experimental tumors. Structural studies clarified that lactimidomycin is a new glutarimide antibiotic having a unique unsaturated 12-membered lactone ring.
Sugawara
K
K
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
Nishiyama
Y
Y
Toda
S
S
Komiyama
N
N
Hatori
M
M
Moriyama
T
T
Sawada
Y
Y
Kamei
H
H
Konishi
M
M
Oki
T
T
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005260:Female; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010881:Piperidones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry*
D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; D018942:Macrolides; D010881:Piperidones; C077633:lactimidomycin