title: Radical-induced oxidation of oxahydrindene (hexahydrobenzofuran) portion of 22,23-dihydroavermectin B1a: identification of autooxidation products.
abstract: Three products resulting from free-radical-induced oxidation of the oxahydrindene portion of 22,23-dihydroavermectin B1a (H2B1a) are 5-oxo-H2B1a, 8a-oxo-H2B1a, and 5,8a-bisoxo-H2B1a. The last of these compounds has not been reported previously.
authors.affiliation: Merck Sharp and Dohme Research Laboratories, Rahway, NJ 07065.
authors.forename: J D
authors.initials: JD
authors.lastname: Stong
authors.forename: J V
authors.initials: JV
authors.lastname: Pivnichny
authors.forename: H
authors.initials: H
authors.lastname: Mrozik
authors.forename: F S
authors.initials: FS
authors.lastname: Waksmunski
mesh_terms: D001572:Benzofurans / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D005609:Free Radicals; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000737:chemistry; D010084:Oxidation-Reduction; D010545:Peroxides / Q000737:chemistry; D020122:tert-Butylhydroperoxide
chemical_list: D001572:Benzofurans; D005609:Free Radicals; D010545:Peroxides; D007559:Ivermectin; C019264:avermectin; C052102:22,23-dihydroavermectin B(1)a; D020122:tert-Butylhydroperoxide