title: Single daily doses of trimethoprim/sulphadiazine for three or 10 days in urinary tract infections.
abstract: We conducted a prospective randomized study to evaluate the efficacy of a single daily dose of 4 mg/kg of trimethoprim coupled with 17.5 mg/kg of sulphadiazine for three (group 1) or 10 days (group 2) in the treatment of uncomplicated urinary tract infections in children. Forty patients (nine boys and 31 girls) aged 2.5-18 years, presenting with a urinary tract infection were allocated to one of the two groups. Patients were seen three, 10, and > or = 38 days after the initiation of treatment. Control urine cultures were negative in all patients at days 3 and 10. Two patients in group 1 and one patient in group 2 suffered a relapse within a month. Single doses of trimethoprim/sulphadiazine for three or 10 days are effective in the treatment of uncomplicated urinary tract infections in children.
authors.affiliation: Department of Paediatrics, University of Montreal, Sainte-Justine Hospital, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Gaudreault
authors.forename: M
authors.initials: M
authors.lastname: Beland
authors.forename: J B
authors.initials: JB
authors.lastname: Girodias
authors.forename: R L
authors.initials: RL
authors.lastname: Thivierge
mesh_terms: D000293:Adolescent; D000892:Anti-Infective Agents, Urinary / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations; D004927:Escherichia coli Infections / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D011446:Prospective Studies; D013203:Staphylococcal Infections / Q000188:drug therapy; D013411:Sulfadiazine / Q000627:therapeutic use*; D013997:Time Factors; D014295:Trimethoprim / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000188:drug therapy*; D000096926:Benzenesulfonamides
chemical_list: D000892:Anti-Infective Agents, Urinary; D004338:Drug Combinations; D013411:Sulfadiazine; D014295:Trimethoprim; C024873:sulfadiazine, trimethoprim drug combination; D000096926:Benzenesulfonamides