Adjuvant therapy for colorectal cancer.
The search for effective adjuvant therapy for colorectal cancer has been long and, until recently, largely unrewarding. Surgery alone is inadequate therapy in as many as 50% of patients. But recent studies demonstrate significant improvement in disease-free survival and overall survival for patients with advanced colon and rectal cancer who receive adjuvant therapy. Postoperative chemotherapy with fluorouracil and levamisole is the standard of care for patients with stage III colon cancer, and postoperative high-dose pelvic radiation combined with fluorouracil is the standard regimen for patients with stage II and III rectal cancer.
Vernava
A M
AM
Department of Surgery, University School of Medicine, St. Louis, MO 63110-0250.
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D015996:Survival Rate
D000970:Antineoplastic Agents; D005472:Fluorouracil