[R proteins as an integral index of the action on the body of industrial allergens in an experiment on white rats].
P proteins were just obtained from white rats and a method to testify them with the help of highly stable anti-P serum was worked out. Normal titres of P proteins are 1:1600 and 1:3200. Different models of sensitisation to the industrial allergens (delivered intracutaneously, by inhalation, into trachea in various doses and concentrations) were used in trials of the method. P protein level appeared to correlate with the sensitisation degree estimated by specific allergy tests. The highest P protein titer is due to the toxic allergic conditions (up to 1:102400), the minimal to sensitization of threshold (up to 1:12800) level. Provocative inhalation test in sensitized rats induced an increase of P protein titer as delayed hypersensitivity was forming.
Dueva
L A
LA
Smirnova
T Iu
TIu
Margulis
G U
GU
D000280:Administration, Inhalation; D000395:Air Pollutants, Occupational / Q000008:administration & dosage / Q000276:immunology*; D000485:Allergens / Q000008:administration & dosage / Q000276:immunology*; D000818:Animals; D001798:Blood Proteins / Q000032:analysis* / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D004391:Dust / Q000009:adverse effects; D006968:Hypersensitivity, Delayed / Q000097:blood; D007114:Immunization / Q000379:methods; D011817:Rabbits; D051381:Rats
D000395:Air Pollutants, Occupational; D000485:Allergens; D001798:Blood Proteins; D004391:Dust
R-belki kak integral'nyĭ pokazatel' deĭstviia na organizm promyshlennykh allergenov v éksperimente na belykh krysakh.