title: Assessment of whole-body composition with dual-energy x-ray absorptiometry.
abstract: Dual-energy x-ray absorptiometry (DXA) allows noninvasive direct measurement of the three major components of body composition: lean body mass (LBM), fat body mass (FBM), and bone mineral body mass (BBM). To study the accuracy and short-term and long-term precision of body composition measurements, the authors measured body composition with DXA in 60 healthy young adults. Independent measurement of LBM (LBMK-40), obtained from the determination of the whole-body content of potassium-40 with a whole-body scintillation detector, was highly correlated with LBM determined with DXA (LBMDXA) (LBMK-40 = 1.069.LBMDXA,R2 = .996). Assessment of body composition in 10 patients with acquired immunodeficiency syndrome (AIDS) and 10 patients with cystic fibrosis was performed with DXA. The AIDS patients showed a marked decrease in LBM, while in patients with cystic fibrosis, LBM and BBM were decreased. DXA measurements of body composition appeared accurate and precise enough to be of clinical relevance in detecting specific alterations of body composition.
authors.affiliation: Division of Nuclear Medicine, Hôpital Cantonal Universitaire, Geneva, Switzerland.
authors.forename: D O
authors.initials: DO
authors.lastname: Slosman
authors.forename: J P
authors.initials: JP
authors.lastname: Casez
authors.forename: C
authors.initials: C
authors.lastname: Pichard
authors.forename: T
authors.initials: T
authors.lastname: Rochat
authors.forename: F
authors.initials: F
authors.lastname: Fery
authors.forename: R
authors.initials: R
authors.lastname: Rizzoli
authors.forename: J P
authors.initials: JP
authors.lastname: Bonjour
authors.forename: A
authors.initials: A
authors.lastname: Morabia
authors.forename: A
authors.initials: A
authors.lastname: Donath
mesh_terms: D015502:Absorptiometry, Photon; D000163:Acquired Immunodeficiency Syndrome / Q000473:pathology; D000273:Adipose Tissue / Q000033:anatomy & histology / Q000737:chemistry; D000328:Adult; D000367:Age Factors; D001823:Body Composition; D001824:Body Constitution; D001827:Body Height; D001830:Body Surface Area; D001835:Body Weight; D015519:Bone Density; D015331:Cohort Studies; D003550:Cystic Fibrosis / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D009132:Muscles / Q000033:anatomy & histology / Q000737:chemistry; D011188:Potassium / Q000032:analysis; D012737:Sex Factors; D013997:Time Factors
chemical_list: D011188:Potassium