title: Liver dysfunction and acute cardiocirculatory failure in children.
abstract: We report 15 children who developed transient liver dysfunction related to hepatic ischaemia. All patients had cardiocirculatory failure 24 h before the onset of liver injury (day 1). Peak serum values of transaminases occurred between day 1 and day 3: SGOT (mean: 759 IU/l, range: 150-4400); SGPT (418 IU/l, 95-2547). Transaminase values decreased rapidly and normalised from day 6 to day 10. Minimum values of prothrombin test (PT) occurred on day 1 (31%, 10-70) and 13/15 patients had a PT less than 50% (27%, 10-44). PT values normalized from day 3 to day 10. Hypoglycaemia was present in 8/15 patients on day 1. Liver dysfunction improved after correction of the circulatory failure. These results confirm that transient hepatic dysfunction, probably as a consequence of hepatic hypoperfusion, may occur frequently in children after acute circulatory failure. We conclude that the diagnosis of ischaemic liver injury or shock liver syndrome in children can be made on clinical and biochemical criteria, and that liver biopsy is unnecessary.
authors.affiliation: Department of Paediatrics, Clocheville Children's Hospital, Tours, France.
authors.forename: E
authors.initials: E
authors.lastname: Jacquemin
authors.forename: E
authors.initials: E
authors.lastname: Saliba
authors.forename: M H
authors.initials: MH
authors.lastname: Blond
authors.forename: A
authors.initials: A
authors.lastname: Chantepie
authors.forename: J
authors.initials: J
authors.lastname: Laugier
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007511:Ischemia / Q000175:diagnosis / Q000209:etiology*; D008099:Liver / Q000098:blood supply*; D008297:Male; D011446:Prospective Studies; D011517:Prothrombin Time; D012770:Shock, Cardiogenic / Q000150:complications*
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase