[Change in the opioid peptide level in the heart and blood plasma during acute myocardia ischemia complicated by ventricular fibrillation].
After occlusion of the anterior descending coronary artery content of opioid peptides was increased 2-3-fold in blood plasma of all the rats with and without ventricular fibrillation. Content of Leu-enkephalin was decreased in ischemic and non-ischemic regions of myocardium under conditions of ventricular fibrillation. At the same time, concentration of Met-enkephalin in myocardium was increased in the acute ischemia independently on the effect of fibrillation. Synthetic enzyme-resistant derivative of Leu-enkephalin, administered before acute myocardial ischemia, prevented a decrease in the ventricular fibrillation threshold caused by the occlusion. Alteration of the Leu-enkephalin content in heart tissue appears to be importance in pathogenesis of ventricular fibrillation developed after acute myocardial ischemia.
Maslov
L N
LN
Lishmanov
Iu B
IuB
D000208:Acute Disease; D000818:Animals; D004743:Enkephalin, Leucine / Q000097:blood / Q000378:metabolism*; D004744:Enkephalin, Methionine / Q000097:blood / Q000378:metabolism*; D008297:Male; D017202:Myocardial Ischemia / Q000097:blood / Q000150:complications / Q000378:metabolism*; D009206:Myocardium / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D014693:Ventricular Fibrillation / Q000150:complications*
D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine
Izmenenie urovnia opioidnykh peptidov v serdtse i plazme krovi pri ostroĭ ishemii miokarda, oslozhnennoĭ fibrilliatsieĭ zheludochkov.