[Effects of human defensin HNP-1 on the production of tumor necrosis factor-alpha by human blood monocytes in vitro].
The influence of human defensin HNP-1 on the synthesis of tumor necrosis factor-alpha (TNF-alpha) by human blood monocytes was studied. It was shown that TNF-alpha production by human monocytes activated by SAC or PMA was augmented in the presence of HNP-1 concentrations of 10(-8)-10(-9) M. HNP-1 alone induced no synthesis of TNF-alpha. High concentration of HNP-1 (10(-4) M) was cytotoxic for human monocytes.
Misuno
N I
NI
Kolesnikova
T S
TS
Lerer
R I
RI
Gants
T
T
Voĭtenok
N N
NN
D001770:Blood Bactericidal Activity; D001798:Blood Proteins / Q000494:pharmacology*; D002478:Cells, Cultured; D023082:Defensins; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D009504:Neutrophils; D013211:Staphylococcus aureus / Q000276:immunology; D013268:Stimulation, Chemical; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*; D023084:alpha-Defensins
D001798:Blood Proteins; D023082:Defensins; D014409:Tumor Necrosis Factor-alpha; D023084:alpha-Defensins; C406413:human neutrophil peptide 1; D013755:Tetradecanoylphorbol Acetate
Vliianie defenzina HNP-1 neĭtrofilov cheloveka na produktsiiu faktora nekroza opukholeĭ-al'fa monotsitami krovi cheloveka in vitro.