[Microsomal hydroxylating system of the mouse liver in toxic forms of influenza infection].
The paper presents the experimental model of toxic influenza infection induced by A/Victory/35/72 (H3N2) strain adapted to CBA mice. The virus toxicosis was shown by means of ESR technique to be accompanied by a decrease of both the content of the active form of cytochrome P-450 and the activity of p-nitroanisole o-demethylase. In microsomes there was activation of lipid peroxidation (LP) and an increase of microviscosity of lipid matrix. LP activation in microsomes was not accompanied by the change of alpha-tocopherol content.
Gorbunov
N V
NV
Volgarev
A P
AP
Bykova
N O
NO
Prozorovskaia
M P
MP
D000818:Animals; D001669:Biochemical Phenomena; D001671:Biochemistry; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D006900:Hydroxylation; D009980:Influenza A virus; D015227:Lipid Peroxidation; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D009976:Orthomyxoviridae Infections / Q000201:enzymology / Q000378:metabolism* / Q000382:microbiology; D010090:Oxidoreductases, O-Demethylating / Q000378:metabolism; D014810:Vitamin E / Q000378:metabolism
D014810:Vitamin E; D003577:Cytochrome P-450 Enzyme System; C026048:4-nitroanisole O-demethylase; D010090:Oxidoreductases, O-Demethylating
Mikrosomnaia gidroksiliruiushchaia sistema pecheni mysheĭ pri toksicheskoĭ forme grippoznoĭ infektsii.