title: Clinical factors affecting mortality in children with malrotation of the intestine.
abstract: In children with symptoms secondary to malrotation of the intestine, a retrospective statistical study was undertaken to identify factors associated with an increased risk of mortality. Between 1964 and 1989, laparatomy was performed on 182 children. For study purposes, the children were divided into three groups. Group I included 71 patients with an obstruction only in the duodenum. The remaining 111 children, all of whom had midgut volvulus, were further divided; those without gut necrosis (79) into group II, and those with necrosis (32) into group III. One child each died in groups I and II, and 15 in group III. In all children we evaluated the relationship between mortality and age at presentation, presence of associated serious abnormalities, time from onset of symptoms to surgery, and the presence of necrotic bowel. For group III, we considered the influence of percentage of bowel resected on mortality. In these 182 children the factors associated with an increased risk of mortality were presence of necrosis (P < .0001), presence of other abnormalities (P = .0008), and younger age (P = .0084). Time from onset of symptoms to surgery was not associated with statistically increased risk of mortality. The 1% mortality noted in children without intestinal necrosis (group I and II) was related to associated abnormality. For group III the estimated probability of survival ranged from .999 for patients with 10% of intestinal necrosis to .351 for whose with 75% of intestinal necrosis, assuming the best prognostic conditions (patient older than 3 months with no associated serious abnormalities).
authors.affiliation: Department of General Surgery, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Messineo
authors.forename: J H
authors.initials: JH
authors.lastname: MacMillan
authors.forename: S B
authors.initials: SB
authors.lastname: Palder
authors.forename: R M
authors.initials: RM
authors.lastname: Filler
mesh_terms: D000015:Abnormalities, Multiple / Q000401:mortality / Q000601:surgery; D002423:Cause of Death; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007238:Infarction / Q000401:mortality / Q000601:surgery; D007415:Intestinal Obstruction / Q000401:mortality* / Q000601:surgery; D007422:Intestines / Q000098:blood supply; D008297:Male; D009864:Ontario / Q000453:epidemiology; D011183:Postoperative Complications / Q000401:mortality*; D012189:Retrospective Studies; D012307:Risk Factors