Role of antibiotics in lipid peroxidation.
Alterations in the levels of lipid peroxides, superoxide dismutase, catalase, glutathione, free fatty acid and serum ceruloplasmin were studied in rats fed with high fat cholesterol diet administered different antibiotics, viz. ampicillin, tetracycline, streptomycin, chloramphenicol and cephalosporin. The concentrations of lipid peroxides, glutathione, free fatty acid decreased in most of the tissues, except in tetracycline, streptomycin and cephalosporin treated rats. The changes observed in the activities of superoxide dismutase and catalase in the liver and kidney of these antibiotics administered groups also are in accordance with the changes in lipid peroxides. The results show that the tetracycline is hepatotoxic and nephrotoxic, while cephalosporin and streptomycin are nephrotoxic.
Vijayalekshmy
K S
KS
Department of Biochemistry, University of Kerala, Thiruvananthapuram.
Menon
V P
VP
Leelamma
S
S
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000633:toxicity; D002374:Catalase / Q000032:analysis; D002570:Ceruloplasmin / Q000032:analysis; D002791:Cholesterol, Dietary; D005227:Fatty Acids / Q000032:analysis; D005978:Glutathione / Q000032:analysis; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000032:analysis; D014018:Tissue Distribution
D000900:Anti-Bacterial Agents; D002791:Cholesterol, Dietary; D005227:Fatty Acids; D002374:Catalase; D013482:Superoxide Dismutase; D002570:Ceruloplasmin; D005978:Glutathione