Characterization of G6PD Rohini--a new class III Indian variant.
A new Indian G6PD variant was detected in a 15 yr old Maratha male during a population screening programme in high school children in Bombay (India). The propositus and two family members having the same variant were apparently healthy. This enzyme variant has a mild erythrocyte G6PD deficiency and a slow electrophoretic mobility. It is characterized by a high Michaelis-Menton constant for G6P, a bimodal curve for pH optima and a slight decrease in the thermostability. The rate of utilization of substrate analogue is similar to that of normal. These observations suggest identification of a new class III variant, designated as G6PD Rohini.
Sayyed
Z
Z
Institute of Immunohaematology, Bombay.
Mukherjee
M B
MB
Mudera
V C
VC
Colah
R
R
Gupte
S
S
D000293:Adolescent; D000328:Adult; D002648:Child; D004592:Electrophoresis, Starch Gel; D004912:Erythrocytes / Q000201:enzymology; D014644:Genetic Variation; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics* / Q000378:metabolism; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D007194:India; D008297:Male; D008403:Mass Screening; D010375:Pedigree
D005954:Glucosephosphate Dehydrogenase