Drug interaction with intraocular lenses of different materials.
The uptake and washout kinetics of four drugs representing different classes of ophthalmic medications were measured in intraocular lenses of different materials. The materials ranged from hydrogel lenses to poly(methyl methacrylate) (PMMA), Acrysof (acrylic/methacrylic), and two types of silicone lenses (Chiroflex and AMO SI-18NB). Uptake was determined after seven days of immersion in a large volume of Ringer's solution containing drug concentrations that equaled those found in aqueous humor 30 minutes to one hour after topical administration. Washout was determined after placing lenses in 1 ml of 0.9% saline for 24 hours. Only hydrogel lenses could be digested in acid to measure lens uptake directly. The PMMA, Acrysof, and silicone lenses behaved similarly toward gentamicin and dexamethasone--low uptake (less than 3.5 ng/mg lens) and low washout (less than 4.0%). Their uptake of norepinephrine was lower (less than 0.7 ng/mg lens) but the washout varied from 29% (AMO silicone) to 100% (PMMA and Acrysof). The pilocarpine uptake was the lowest of drugs tested (less than 0.03 ng/mg lens) and the washout varied from 1.5% (acrylic) to 100% (PMMA and Chiroflex silicone). Hydrogel lenses took up the most drug in the following order: dexamethasone greater than pilocarpine greater than gentamicin greater than norepinephrine. Washout was high, ranging from 83% to 98%. Despite the greater uptake and washout, the maximum drug uptake would only provide one-tenth of the greatest aqueous humor concentration that occurs after topical drug administration. Intraocular lenses of the materials tested did not interfere with the intraocular drug pharmacokinetics, nor did the data indicate that presoaking intraocular lenses of these materials in drugs would enhance post-surgical intraocular drug concentrations.
Chapman
J M
JM
Department of Ophthalmology, Medical College of Georgia, Augusta 30912-3400.
Cheeks
L
L
Green
K
K
D000042:Absorption; D003907:Dexamethasone / Q000494:pharmacology; D004347:Drug Interactions; D005839:Gentamicins / Q000494:pharmacology; D007910:Lenses, Intraocular; D009638:Norepinephrine / Q000494:pharmacology; D009883:Ophthalmic Solutions / Q000494:pharmacology*; D010862:Pilocarpine / Q000494:pharmacology; D011108:Polymers / Q000494:pharmacology*
D005839:Gentamicins; D009883:Ophthalmic Solutions; D011108:Polymers; D010862:Pilocarpine; D003907:Dexamethasone; D009638:Norepinephrine