[Role of alpha-tocopherol and retinol in the antiradical protection of the body in peptic ulcer].
Retinol and tocopherol content, the intensity of spontaneous chemiluminescence as well as concentration of malonic dialdehyde in the blood of practically healthy persons of different age groups and in patients with gastric and duodenal ulcer have been studied. Results are presented. The lower content of tocopherol was revealed in the young persons as compared with other age groups, while the level of vitamin A was not established to depend on age. The content of tocopherol is established to decrease in the blood serum under peptic ulcer. Under these conditions low level of retinol correlates with considerable growth of spontaneous chemiluminescence. Reserve interrelation of tocopherol content in the blood with the level of spontaneous chemiluminescence as well as the absence of true dependence on the concentration of malonic dialdehyde at peptic ulcer are proved. Mechanisms of participation of vitamins E and A in the inhibition of free-radical reactions are discussed, role of their deficiency in pathogenesis fo peptic ulcer is substantiated.
Kolomoets
M Iu
MIu
Kuz'menko
I V
IV
Chernukhina
L A
LA
Klimenko
E P
EP
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood; D004381:Duodenal Ulcer / Q000097:blood / Q000503:physiopathology*; D005260:Female; D005609:Free Radicals; D006801:Humans; D049449:Luminescence; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D013276:Stomach Ulcer / Q000097:blood / Q000503:physiopathology*; D014801:Vitamin A / Q000097:blood / Q000502:physiology*; D014810:Vitamin E / Q000097:blood / Q000502:physiology*
D005609:Free Radicals; D014801:Vitamin A; D014810:Vitamin E; D008315:Malondialdehyde
Rol' alpha-tokoferola i retinola v antiradikal'noĭ zashchite organizma pri iazvennoĭ bolezni.