Radioresistant cells of thymus--producers and targets of thymocyte growth factor and their possible role in postradiation restoration of thymus.
In the present study the association between the damaging and the stimulating action of radiation on the cells of thymus (in particular intrathymic T-lymphocyte precursors, TLP) is analyzed. The radioresistance and possibility to secrete humoral products, in particular, the thymocytes growth factor, THGF, is assessed. The possible role of THGF in the postradiation restoration of thymus is also discussed.
Shichkin
V P
VP
Department of Medical Diagnostics, Institute of Biotechnology, Moscow, Russia.
D000818:Animals; D002460:Cell Line; D005260:Female; D006412:Hematopoietic Stem Cells / Q000528:radiation effects; D007376:Interleukin-2 / Q000096:biosynthesis*; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D011836:Radiation Tolerance; D013601:T-Lymphocytes / Q000528:radiation effects; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology / Q000528:radiation effects*
D007376:Interleukin-2