[Activation of free radicals reaction and changes in the state of antioxidant protection in blood in toxic experimental influenza infection].
The paper presents an experimental model of toxic influenza infection. The toxic form of influenza was shown to result in the activation of free radical processes accompanied by the accumulation of both lipid peroxidation products and methemoglobin and the decrease of alpha-tocopherol in erythrocytes, by the accumulation of NO. and nitrizyl complexes of heme iron in the blood. The activation of free radical processes was followed by the stimulation of antioxidant system in the blood. Thus, there was an increase of both superoxide dismutase activity in erythrocytes and ceruloplasmin content in the blood. The data obtained support the important role of the active products of free radical processes in the development of toxicosis under acute virus infections.
Gorbunov
N V
NV
Volgarev
A P
AP
Braĭlovskaia
I V
IV
Bykova
N O
NO
Avrova
N F
NF
Kiselev
O I
OI
D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002570:Ceruloplasmin / Q000032:analysis; D004912:Erythrocytes / Q000378:metabolism; D005609:Free Radicals; D015227:Lipid Peroxidation; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009976:Orthomyxoviridae Infections / Q000097:blood / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000097:blood; D014810:Vitamin E / Q000097:blood
D000975:Antioxidants; D005609:Free Radicals; D014810:Vitamin E; D013482:Superoxide Dismutase; D002570:Ceruloplasmin
Aktivatsiia svobodnoradikal'nykh reaktsiĭ i izmenenie sostoianiia sistemy antioksidantnoĭ zashchity v krovi pri toksicheskoĭ éksperimental'noĭ grippoznoĭ infektsii.