[Activity of polar glycopeptidolipids from Mycobacterium chelonae in the reversal of chemically induced leukopenia in mice].
Intraperitoneal administration of polar glycopeptidolipids extracted from Mycobacterium chelonae (GPLp-Mc) has led to reversal of Doxorubicin-induced leucopenia in a manner comparable to that effected by GM-CSF administered in a dose of 100 IU (2.5 micrograms/kg). The mode of action and the toxicity of this product are being studied. Results obtained on the mouse indicate that it would be worthwhile to undertake tests in man aimed at studying the effect of GPLp-Mc on chemotherapy- and radiotherapy-induced leukopenias, once toxicological studies have been carried out.
Neway
T
T
Institut d'Immunologie animale et comparée, Ecole nationale vétérinaire d'Alfort, Maisons-Alfort.
Boulouis
H J
HJ
Thibault
D
D
Pilet
C
C
D000818:Animals; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000494:pharmacology; D005260:Female; D006017:Glycolipids / Q000008:administration & dosage*; D006020:Glycopeptides / Q000008:administration & dosage*; D007274:Injections, Intraperitoneal; D007970:Leukopenia / Q000139:chemically induced / Q000188:drug therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D016926:Mycobacterium chelonae / Q000737:chemistry*; D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
D006017:Glycolipids; D006020:Glycopeptides; D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; D004317:Doxorubicin
Activité des glycopeptidolipides polaires de Mycobacterium chelonae sur la restauration d'une leucopénie chimioinduite chez la souris.