E2F: a link between the Rb tumor suppressor protein and viral oncoproteins.
The cellular transcription factor E2F, previously identified as a component of early adenovirus transcription, has now been shown to be important in cell proliferation control. E2F appears to be a functional target for the action of the tumor suppressor protein Rb that is encoded by the retinoblastoma susceptibility gene. The disruption of this E2F-Rb interaction, as well as a complex involving E2F in association with the cell cycle-regulated cyclin A-cdk2 kinase complex, may be a common mechanism of action for the oncoproteins encoded by the DNA tumor viruses.
Nevins
J R
JR
Howard Hughes Medical Institute, Section of Genetics, Duke University Medical Center, Durham, NC 27710.
D017500:Adenovirus E1A Proteins / Q000378:metabolism; D000260:Adenoviruses, Human / Q000235:genetics; D001665:Binding Sites; D002352:Carrier Proteins; D002453:Cell Cycle; D018797:Cell Cycle Proteins; D002472:Cell Transformation, Viral; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000378:metabolism; D050684:E2F Transcription Factors; D015967:Gene Expression Regulation, Viral; D016147:Genes, Tumor Suppressor; D006801:Humans; D009856:Oncogene Proteins, Viral / Q000378:metabolism*; D011485:Protein Binding; D012045:Regulatory Sequences, Nucleic Acid; D016160:Retinoblastoma Protein / Q000378:metabolism*; D056465:Retinoblastoma-Binding Protein 1; D050680:Transcription Factor DP1; D014157:Transcription Factors / Q000378:metabolism*
D017500:Adenovirus E1A Proteins; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D009856:Oncogene Proteins, Viral; D016160:Retinoblastoma Protein; D056465:Retinoblastoma-Binding Protein 1; D050680:Transcription Factor DP1; D014157:Transcription Factors