Oxidative decarboxylation of naproxen.
The decarboxylation of naproxen (1H) and its salt (1-) was achieved by means of chemical [Ce(IV) or S2O8(2-)] and electrochemical oxidation. The product patterns were compatible with mechanisms involving single-electron transfer from the pi-system or the carboxylate moiety. The results are discussed in connection with the involvement of electron-transfer processes in the reported phototoxicity of naproxen.
Boscá
F
F
Departamento de Química, Universidad Politécnica de Valencia, Spain.
Martínez-Máñez
R
R
Miranda
M A
MA
Primo
J
J
Soto
J
J
Vañó
L
L
D004563:Electrochemistry / Q000379:methods; D009288:Naproxen / Q000737:chemistry*; D016877:Oxidants / Q000737:chemistry; D010084:Oxidation-Reduction; D012997:Solvents / Q000737:chemistry
D016877:Oxidants; D012997:Solvents; D009288:Naproxen