Developmental changes of EAA metabotropic receptor activity in rat cerebellum.
The potency but not the efficacy of t-ACPD stimulation of phosphatydil inositide hydrolysis changes in developing rat cerebellum. This suggests that the excitatory amino-acid-stimulated metabotropic receptors and/or their coupling are ontogenically regulated. In this, cerebellum differs from other CNS regions where only efficacy changes were described. Differently from hippocampus, the t-ACPD effect, at all ages, is independent of the activation of the NMDA receptor.
Gombos
G
G
Centre de Neurochimie du C.N.R.S., Strasbourg, France.
Levy
O
O
de Barry
J
J
D000375:Aging / Q000378:metabolism; D000818:Animals; D002531:Cerebellum / Q000254:growth & development / Q000378:metabolism*; D003515:Cycloleucine / Q000031:analogs & derivatives / Q000494:pharmacology; D006868:Hydrolysis; D007294:Inositol / Q000378:metabolism; D007295:Inositol Phosphates / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar; D017459:Receptors, Amino Acid / Q000378:metabolism*
D007295:Inositol Phosphates; D017459:Receptors, Amino Acid; D003515:Cycloleucine; C036361:1-amino-1,3-dicarboxycyclopentane; D007294:Inositol