title: [The valvular effect of the skin in electrophoresis with an alternating polarity of the electrodes].
abstract: The effectiveness of iontophoresis by means of changing current direction was investigated on the skin of piglets using labelled potassium iodide (125I and 131I). Permeability without current served control. Percutaneous uptake was measured by blood levels and elimination of the isotopes from the urine. About a 200-fold increase of uptake was found in iontophoresis involving current change every 120 seconds and the concentration of 0.25 g/l of potassium iodide. Anions and cations may be pumped through the horny layer if the a-c frequency is less than 1/15 s-i.
authors.forename: H G
authors.initials: HG
authors.lastname: Pratsel
authors.forename: B
authors.initials: B
authors.lastname: Roesel
mesh_terms: D000818:Animals; D002463:Cell Membrane Permeability / Q000502:physiology; D004566:Electrodes; D007457:Iodine Radioisotopes; D007478:Iontophoresis / Q000295:instrumentation* / Q000379:methods; D011193:Potassium Iodide / Q000008:administration & dosage / Q000493:pharmacokinetics; D012869:Skin Absorption / Q000502:physiology*; D012996:Solutions; D013552:Swine
chemical_list: D007457:Iodine Radioisotopes; D012996:Solutions; D011193:Potassium Iodide
vernacular_title: Klapannyĭ éffekt kozhi pri élektroforeze s peremennoĭ poliarnost'iu élektrodov.