Gentisate pathway in Salmonella typhimurium: metabolism of m-hydroxybenzoate and gentisate.
Salmonella typhimurium was shown to use the gentisate pathway to metabolize m-hydroxybenzoate and gentisate, m-Hydroxybenzoate hydroxylase and gentisate 1,2-dioxygenase were induced by growth on either gentisate or m-hydroxybenzoate. These enzymes were not detected when the bacteria were grown with glucose or glucose and either m-hydroxybenzoate or gentisate. However, both enzymes were induced when the bacteria were grown on succinate with either substrate. The maleylpyruvate isomerase required reduced glutathione and was irreversibly inhibited by N-ethylmaleimide.
Goetz
F E
FE
Biology Department, Mankato State University, Minnesota 56001.
Harmuth
L J
LJ
D049308:Dioxygenases; D005841:Gentisates; D005947:Glucose / Q000378:metabolism; D062385:Hydroxybenzoates / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000378:metabolism; D010105:Oxygenases / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D012486:Salmonella typhimurium / Q000254:growth & development / Q000378:metabolism*
D005841:Gentisates; D062385:Hydroxybenzoates; D011773:Pyruvates; C032948:3-hydroxybenzoic acid; D019289:Pyruvic Acid; D006899:Mixed Function Oxygenases; D010105:Oxygenases; D049308:Dioxygenases; C026247:gentisate 1,2-dioxygenase; C021385:3-hydroxybenzoate-4-monooxygenase; D005947:Glucose; C010925:2,5-dihydroxybenzoic acid