[Down-regulation of liver regeneration by LAK cells--a study for effect of neuraminidase treated LAK cells on liver regeneration].
Both effect of LAK cells and neuraminidase treated LAK (N-LAK) cells on liver regeneration were investigated after 70% partial hepatectomy in mice. Intravenous transfusion of LAK cells suppressed the liver regeneration depending on cell numbers injected. N-LAK cells accumulated into regenerating liver 1.7 times in cell number compared with LAK cells. Injection of 5 x 10(7) LAK cells and N-LAK cells into hepatectomized mice suppressed the liver regeneration by 16.5% and 53.8% respectively. These results indicated that suppression of the liver regeneration by LAK cells was dependent upon the number of injected LAK cells and the degree of accumulation of LAK cells into the liver, namely, LAK cells down-regulate the regeneration of liver cells in the micro-milieu.
Tatemoto
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A
First Department of Surgery, Okayama University School of Medicine, Japan.
D000818:Animals; D015536:Down-Regulation; D015979:Killer Cells, Lymphokine-Activated / Q000187:drug effects / Q000502:physiology*; D008115:Liver Regeneration; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009439:Neuraminidase / Q000494:pharmacology*
D009439:Neuraminidase