title: Norepinephrine increases the economy of pressure development in isolated canine hearts.
abstract: To test for oxygen wasting by norepinephrine (NE) without relying on normalization by measures of performance such as the pressure-volume area, myocardial oxygen consumption (MVO2) was determined for isovolumic beats at five different left ventricular (LV) end-diastolic volumes (EDV) in nine isolated cross-perfused canine hearts in each of three states: a basal anesthetic state (B); after depression with halothane (H); and after adding NE to increase contractility back to the B state (H+NE). The end-diastolic and peak systolic pressure-volume lines were identical for B and H+NE. The R2 for a linear regression of MVO2 per beat for B vs. H+NE for beats originating at the same EDV and developing similar (within 10%) peak isovolumic pressures for all hearts was 0.85. The slope and intercept were 0.83 and 0.01, which are significantly less than one (P less than 0.001) and greater than zero (P less than 0.001), respectively. These data suggest that NE increases both the economy of pressure development as well as activation energy of an isovolumically contracting LV.
authors.affiliation: Department of Anesthesia, Massachusetts General Hospital, Boston 02114.
authors.forename: J W
authors.initials: JW
authors.lastname: Allyn
authors.forename: R
authors.initials: R
authors.lastname: Teplick
authors.forename: J B
authors.initials: JB
authors.lastname: Steinberg
authors.forename: N A
authors.initials: NA
authors.lastname: Munfakh
authors.forename: G A
authors.initials: GA
authors.lastname: Geffin
authors.forename: J
authors.initials: J
authors.lastname: Titus
authors.forename: W M
authors.initials: WM
authors.lastname: Daggett
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D001810:Blood Volume; D003326:Coronary Circulation / Q000187:drug effects*; D003971:Diastole; D004285:Dogs; D006221:Halothane / Q000494:pharmacology; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000494:pharmacology*; D010101:Oxygen Consumption; D013599:Systole
chemical_list: D006221:Halothane; D009638:Norepinephrine