Hairy cell leukemia and factor VIII inhibitor: a case report.
Acquired factor VIII inhibitors are usually described in hemophilia A, although some cases have been documented in chronic inflammatory diseases and malignant tumors. We report here the first case of a factor VIII inhibitor appearing in the course of hairy cell leukemia. Interferon therapy over a 5 month period led to complete remission of leukemia with parallel disappearance of the acquired factor VIII inhibitor.
Komminoth
A
A
Service d'Onco-Hématologie, CHU Hautepierre, Strasbourg, France.
Dufour
P
P
Bergerat
J P
JP
Wiesel
M L
ML
Falkenrodt
A
A
Oberling
F
F
D005169:Factor VIII / Q000037:antagonists & inhibitors*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D007943:Leukemia, Hairy Cell / Q000097:blood* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012074:Remission Induction / Q000379:methods
D016898:Interferon-alpha; D005169:Factor VIII