title: Relationship of [3H]Ara-C incorporation and response to therapy with high-dose Ara-C in AML patients: a Leukemia Intergroup study.
abstract: Pretherapy bone marrow (BM) aspirates of 143 patients with acute myeloid leukemia (AML) were incubated simultaneously with bromodeoxyuridine (BrdU) and tritiated cytosine arabinoside ([3H]Ara-C) to determine the labeling index (LI) and extent of [3H]Ara-C incorporation. Of 143 AML patients, 121 received high-dose Ara-C (HDAra-C) as a single agent for induction therapy (55 newly diagnosed, 66 in first relapse), whereas 22 received HDAra-C plus mAMSA. The data demonstrate that a subset of patients who will fail HDAra-C remission induction therapy because of drug-resistant disease can be prospectively identified on the basis of the low amount of Ara-C incorporated by their leukemia cells.
authors.affiliation: Roswell Park Memorial Institute, Buffalo, New York.
authors.forename: A
authors.initials: A
authors.lastname: Raza
authors.forename: S
authors.initials: S
authors.lastname: Gezer
authors.forename: J
authors.initials: J
authors.lastname: Anderson
authors.forename: J
authors.initials: J
authors.lastname: Lykins
authors.forename: J
authors.initials: J
authors.lastname: Bennett
authors.forename: G
authors.initials: G
authors.lastname: Browman
authors.forename: J
authors.initials: J
authors.lastname: Goldberg
authors.forename: R
authors.initials: R
authors.lastname: Larson
authors.forename: R
authors.initials: R
authors.lastname: Vogler
authors.forename: H D
authors.initials: HD
authors.lastname: Preisler
mesh_terms: D000208:Acute Disease; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology; D001973:Bromodeoxyuridine / Q000378:metabolism; D003561:Cytarabine / Q000378:metabolism* / Q000627:therapeutic use*; D004273:DNA, Neoplasm / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D016196:S Phase; D014316:Tritium; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism / Q000473:pathology
chemical_list: D004273:DNA, Neoplasm; D003561:Cytarabine; D014316:Tritium; D001973:Bromodeoxyuridine