title: Allergic reactions to penicillin during in vitro fertilization and intrauterine insemination.
abstract: Two cases are reported in which hypersensitivity reactions occurred after intrauterine placement of spermatozoa or embryos. Because the cells were processed and transferred in antibiotic-containing media, these reactions were suspected to be because of penicillin allergy. One patient had no prior penicillin allergy but was found to be penicillin allergic by skin testing. The other had a history of allergy to oral penicillin. In both cases, the allergy symptoms did not occur during subsequent cycles when antibiotics were removed from the transfer media. These reports suggest that in patients known to be penicillin sensitive, penicillin should not be used during transfer of gametes and embryos for assisted reproductive procedures. In addition, the routine use of antibiotics in these procedures should be scientifically evaluated.
authors.affiliation: Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor.
authors.forename: Y R
authors.initials: YR
authors.lastname: Smith
authors.forename: W W
authors.initials: WW
authors.lastname: Hurd
authors.forename: A C
authors.initials: AC
authors.lastname: Menge
authors.forename: G M
authors.initials: GM
authors.lastname: Sanders
authors.forename: R
authors.initials: R
authors.lastname: Ansbacher
authors.forename: J F
authors.initials: JF
authors.lastname: Randolph
mesh_terms: D000328:Adult; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007315:Insemination, Artificial / Q000379:methods; D010406:Penicillins / Q000009:adverse effects*; D014599:Uterus
chemical_list: D010406:Penicillins