Thymulin and its role in immunomodulation.
Even though thymulin was isolated, sequenced and characterised some 20 years ago and later identified as a thymic hormone involved in immunomodulation, much more work is still required to further understanding of the mechanisms of action(s) of this peptide. Since the observation, by a semiquantitative bioassay, of diminished levels of thymulin in immunodeficiency and autoimmune disease, new data obtained by radioimmunoassay have not only confirmed previous observations but also demonstrated that thymulin plays a role in the interaction between the immune system and the neuro-endocrine system. In this paper we give an up to date account of recent developments in research into the role of thymulin in immunomodulation.
Safieh-Garabedian
B
B
Lupus/Arthritis Research Unit, Rayne Institute, St. Thomas' Hospital, London, UK.
Kendall
M D
MD
Khamashta
M A
MA
Hughes
G R
GR
D000595:Amino Acid Sequence; D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy; D006801:Humans; D007107:Immune System / Q000502:physiology*; D008969:Molecular Sequence Data; D013935:Thymic Factor, Circulating / Q000502:physiology* / Q000627:therapeutic use
D013935:Thymic Factor, Circulating