Suppression of experimental autoimmune uveoretinitis by prazosin, an alpha 1-adrenergic receptor antagonist.
S-antigen (S-Ag)-induced experimental autoimmune uveoretinitis (EAU) was suppressed in Lewis and PVG rats by treatment beginning 4 days post immunization with prazosin, a specific alpha 1-adrenergic receptor antagonist. A significant suppression of EAU was observed at clinical and histological levels in both treated groups compared to a severe EAU which developed in controls. Fluorescein angiography showed no leakage of dye from the optic disc of a treated PVG rat presenting no ocular inflammation by clinical examination. The treatment had no effect on the titer of anti-S-Ag antibodies. Perivascular infiltrates of T-lymphocytes and macrophages together with alterations of blood-retinal barrier permeability are early events in EAU. Prazosin, by acting on the vascular alpha 1-adrenoreceptors, inhibits vasospasm, preserves blood-retinal-barrier integrity and prevents vascular edema and early inflammatory cell infiltration observed in EAU.
Ruiz-Moreno
J M
JM
Laboratoire d'Immunopathologie de l'Oeil, INSERM U 86, Paris, France.
Misiuk-Hojlo
M
M
Thillaye
B
B
de Kozak
Y
Y
D000818:Animals; D000941:Antigens; D019393:Arrestin; D001324:Autoantigens; D001327:Autoimmune Diseases / Q000276:immunology* / Q000517:prevention & control; D002199:Capillary Permeability; D004195:Disease Models, Animal; D005136:Eye Proteins; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D007165:Immunosuppression Therapy; D011224:Prazosin / Q000627:therapeutic use*; D051381:Rats; D011917:Rats, Inbred Lew; D012171:Retinal Vessels / Q000473:pathology; D012173:Retinitis / Q000276:immunology* / Q000517:prevention & control; D014605:Uveitis / Q000276:immunology* / Q000517:prevention & control
D000941:Antigens; D019393:Arrestin; D001324:Autoantigens; D005136:Eye Proteins; D011224:Prazosin