title: The effect of postoperative radiotherapy on leukocyte zinc, serum trace elements and nutritional status of breast cancer patients.
abstract: Mononuclear (MNC) and polymorphonuclear cell (PMNC) zinc content was determined together with serum zinc, copper, selenium and iron concentrations in 24 operable breast cancer patients during and after postoperative radiotherapy. Anthropometric and biochemical indices of nutritional status were measured as background data. The measurements were carried out in the years 1987-1988. Nine patients used unconventional multivitamin or trace element preparations. A steady but statistically insignificant decrease in PMNC zinc was seen during treatment. No changes occurred in MNC zinc. Serum copper levels increased in five patients possibly due to tamoxifen treatment, but no other alterations occurred in serum trace element levels. Appetite was well maintained and nutritional status remained unaltered. Postoperative radiotherapy for breast carcinoma had thus no effect on either trace element or nutritional status. Patient-initiated alternative treatments did not significantly affect their trace element levels. This was probably due to small supplementation doses or irregular use of the preparations.
authors.affiliation: Department of Anaesthesiology, University of Turku, Finland.
authors.forename: H M
authors.initials: HM
authors.lastname: Antila
authors.forename: M S
authors.initials: MS
authors.lastname: Salo
authors.forename: V
authors.initials: V
authors.lastname: Näntö
authors.forename: V
authors.initials: V
authors.lastname: Nikkanen
authors.forename: O
authors.initials: O
authors.lastname: Kirvelä
mesh_terms: D001943:Breast Neoplasms / Q000097:blood* / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000737:chemistry*; D008875:Middle Aged; D009752:Nutritional Status; D012643:Selenium / Q000097:blood; D014131:Trace Elements / Q000097:blood*; D015032:Zinc / Q000097:blood*
chemical_list: D014131:Trace Elements; D012643:Selenium; D015032:Zinc