title: Effect of age-related lipid peroxidation on membrane fluidity and phospholipase A2: modulation by dietary restriction.
abstract: Age-related changes in membrane property are generally accepted phenomena. In this report, using the anti-lipoperoxidative measure of dietary restriction on membranes, the age-related effects of lipid peroxidation on membrane fluidity are explored in conjunction with the membrane-associated phospholipase A2. The fluidity of mitochondrial and microsomal membranes from ad libitum fed rats shows a progressive decline with age as indicated by a substantial decrease in two parameters, l/polarization and l/anisotropy. In contrast, the membrane fluidity of dietary restricted rats shows slight changes between 6 and 24 months of age. Evidence is presented to support the possibility that age-related peroxidation of membrane lipids may play a significant role in bringing about fluidity changes in aged membranes. The findings on the increased phospholipase A2 with age is also consistent with this conclusion.
authors.affiliation: University of Texas Health Science Center, Department of Physiology, San Antonio 78284-7756.
authors.forename: B P
authors.initials: BP
authors.lastname: Yu
authors.forename: E A
authors.initials: EA
authors.lastname: Suescun
authors.forename: S Y
authors.initials: SY
authors.lastname: Yang
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D004032:Diet; D007425:Intracellular Membranes / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D008560:Membrane Fluidity; D008862:Microsomes, Liver / Q000378:metabolism; D008930:Mitochondria, Liver / Q000378:metabolism; D010741:Phospholipases A / Q000378:metabolism; D054467:Phospholipases A2; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D010741:Phospholipases A; D054467:Phospholipases A2