title: [Effect of 0-(beta-hydroxyethyl)-rutoside (Venoruton) on symptomatic venous insufficiency in the lower limbs].
abstract: Forty-three patients recruited from general practice with symptom-producing chronic venous insufficiency in the lower limbs participated in a randomized double-blind clinical trial with Venoruton (300 mg x 3) or a placebo for 28 days. Twenty-eight patients were treated with Venoruton and 19 with a placebo. None of the patients received other forms of treatment for chronic venous insufficiency. No differences were observed between the two groups as regards changes in symptoms (swelling, pain, heaviness, restlessness, itching and cramps) the subjective assessment of the discomfort in the extremities or the circumference of the limbs. Venoruton does not appear to have any effect on chronic venous insufficiency in the lower limbs.
authors.affiliation: Københavns Kommunehospital, Medicinsk afdeling 3.
authors.forename: F M
authors.initials: FM
authors.lastname: Pedersen
authors.forename: O
authors.initials: O
authors.lastname: Hamberg
authors.forename: M D
authors.initials: MD
authors.lastname: Sørensen
authors.forename: K
authors.initials: K
authors.lastname: Neland
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D006801:Humans; D006896:Hydroxyethylrutoside / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D014689:Venous Insufficiency / Q000188:drug therapy*
chemical_list: D006896:Hydroxyethylrutoside; C005865:troxerutin
vernacular_title: 0-(beta-hydroxyaetyl)-rutosids (Venoruton) effekt på symptomgivende kronisk venøs insufficiens i underekstremiteterne.