title: Pyrrylphenylethanones related to cathinone and lefetamine: synthesis and pharmacological activities.
abstract: The synthesis of various pyrrylphenylethanones resembling cathinone and lefetamine is described starting from 2-chloro-1-(1-methyl-1H-pyrrol-2-yl)-2-phenylethan-1-one. Some derivatives showed good antinociceptic activity, comparable to that of morphine. The neuropsychopharmacological profile of title compounds has been also studied to explore their action on C.N.S.
authors.affiliation: Dipartimento di Studi farmaceutici, Università di Roma, La Sapienza, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Massa
authors.forename: R
authors.initials: R
authors.lastname: Di Santo
authors.forename: A
authors.initials: A
authors.lastname: Mai
authors.forename: M
authors.initials: M
authors.lastname: Artico
authors.forename: G C
authors.initials: GC
authors.lastname: Pantaleoni
authors.forename: R
authors.initials: R
authors.lastname: Giorgi
authors.forename: M F
authors.initials: MF
authors.lastname: Coppolino
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D005260:Female; D007659:Ketones / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D009125:Muscle Relaxants, Central / Q000138:chemical synthesis / Q000494:pharmacology; D010627:Phenethylamines / Q000737:chemistry*; D011619:Psychotropic Drugs / Q000138:chemical synthesis* / Q000494:pharmacology; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D000700:Analgesics; D000927:Anticonvulsants; D007659:Ketones; D009125:Muscle Relaxants, Central; D010627:Phenethylamines; D011619:Psychotropic Drugs; D011758:Pyrroles; C011896:lephetamine; C023665:cathinone