Antimutagenic activity of plumbagin in Ames Salmonella typhimurium test.
This paper reports the antimutagenic activity of plumbagin (5-hydroxy-2-methyl-1, 4-naphthoquinone) against certain known chemical mutagens in a standard mutagenicity test system of Ames using S. typhimurium strains. Plumbagin by itself did not show any mutagenic effect, whereas it reduced significantly the mutagenic effect of 4-nitrophenylene diammine, phenyl hydrazine and sodium azide in test strains of S. typhimurium, suggesting that plumbagin possessed antimutagenic activity.
Durga
R
R
Department of Microbiology, Osmania University, Hyderabad.
Sridhar
P
P
Polasa
H
H
D001386:Azides / Q000037:antagonists & inhibitors; D006801:Humans; D007202:Indicators and Reagents; D016296:Mutagenesis / Q000187:drug effects*; D009152:Mutagenicity Tests; D009285:Naphthoquinones / Q000494:pharmacology*; D010659:Phenylhydrazines / Q000037:antagonists & inhibitors; D012486:Salmonella typhimurium; D019810:Sodium Azide
D001386:Azides; D007202:Indicators and Reagents; D009285:Naphthoquinones; D010659:Phenylhydrazines; C030299:phenylhydrazine; D019810:Sodium Azide; C014758:plumbagin