title: Vimentin metaplasia in renal cortical tubules of preneoplastic, neoplastic, aging, and regenerative lesions of rats and humans.
abstract: Vimentin expression was studied immunohistochemically in renal cortical tubules of untreated male rats of various ages, rats exposed to toxins (barbital sodium, folic acid) and carcinogens (streptozotocin, N-bis(2-hydroxypropyl)nitrosamine, barbital sodium, and in humans of various ages with or without renal epithelial tumors. Fetal, neonatal, and young adult rats did not express vimentin in renal cortical tubules. Regenerative renal tubular lesions from rats with aging nephropathy and from rats with toxic nephropathy both expressed vimentin. Mitogenic lesions induced by folic acid at 24 hours, however, were not immunoreactive for vimentin. Carcinogen-induced preneoplastic renal cortical tubular lesions in rats were most often focally immunoreactive whereas strong vimentin expression was found in almost all induced renal tumors. In kidneys of three children (younger than 2 years of age), vimentin was not found in renal cortical tubular cells except in rare individual cells in one case. Vimentin was abundant in basophilic regenerative tubules in kidneys of aged individuals, however. Most (7/10) human renal carcinomas and latent preneoplastic or neoplastic renal tubular lesions found incidentally at autopsy (2/4) showed vimentin expression. The authors suggest that the switching to vimentin expression in phenotypically normal renal cortical tubular cells in rats and humans, which do not usually express the intermediate filament protein vimentin, should be considered vimentin metaplasia. Vimentin expression is dissociated from increased cell proliferation in hyperplastic and neoplastic lesions, however. Instead the degree of dedifferentiation of the tubule cells and changes in phenotype were associated with vimentin expression.
authors.affiliation: Tumor Pathology and Pathogenesis Section, National Cancer Institute, Frederick Cancer Research and Development Center, MD 21702-1201.
authors.forename: J M
authors.initials: JM
authors.lastname: Ward
authors.forename: J L
authors.initials: JL
authors.lastname: Stevens
authors.forename: N
authors.initials: N
authors.lastname: Konishi
authors.forename: Y
authors.initials: Y
authors.lastname: Kurata
authors.forename: H
authors.initials: H
authors.lastname: Uno
authors.forename: B A
authors.initials: BA
authors.lastname: Diwan
authors.forename: T
authors.initials: T
authors.lastname: Ohmori
mesh_terms: D000367:Age Factors; D000368:Aged; D000818:Animals; D000831:Animals, Newborn; D005333:Fetus / Q000378:metabolism; D006801:Humans; D007680:Kidney Neoplasms / Q000378:metabolism*; D007684:Kidney Tubules / Q000378:metabolism*; D008297:Male; D011230:Precancerous Conditions / Q000378:metabolism*; D051381:Rats; D012038:Regeneration; D014746:Vimentin / Q000378:metabolism*
chemical_list: D014746:Vimentin