Delayed replication of Xq27 in individuals with the fragile X syndrome.
The timing of late replicating bands on the X chromosome has been studied in individuals with the fragile X [fra(X)] syndrome. Compared to controls both affected individuals and symptomless carriers of the syndrome show delayed replication of the Xq27 region as shown by 2 different methods. The implications of this finding are discussed in relation to the proposal [Laird et al., 1987] that the fraX syndrome is associated with a failure to reactivate the Xq27 band correctly after it has been inactivated in a female.
Webb
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Department of Clinical Genetics, University of Birmingham, Birmingham Maternity Hospital, Edgbaston, England, United Kingdom.
D004247:DNA / Q000737:chemistry / Q000235:genetics; D004261:DNA Replication; D004303:Dosage Compensation, Genetic; D005260:Female; D005600:Fragile X Syndrome / Q000235:genetics*; D006801:Humans; D008297:Male; D008745:Methylation; D008957:Models, Genetic; D014960:X Chromosome
D004247:DNA