title: Hyperventilation-induced cerebral ischemia in panic disorder and effect of nimodipine.
abstract: Basilar artery blood flow was measured by transcranial Doppler ultrasonography before and during hyperventilation in nine patients with panic disorder and nine normal comparison subjects. The hyperventilation-induced decrease in basilar artery blood flow was significantly greater in patients with panic attacks than in comparison subjects. Two patients with decreases in basilar flow greater than 80% were successfully treated with nimodipine, a centrally active calcium channel blocker.
authors.affiliation: Department of Neurology, Good Samaritan Hospital and Medical Center, Portland, Ore.
authors.forename: D M
authors.initials: DM
authors.lastname: Gibbs
mesh_terms: D000328:Adult; D001488:Basilar Artery / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology; D001783:Blood Flow Velocity / Q000187:drug effects; D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D006985:Hyperventilation / Q000150:complications*; D008297:Male; D009553:Nimodipine / Q000494:pharmacology / Q000627:therapeutic use*; D016584:Panic Disorder / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D014463:Ultrasonography
chemical_list: D009553:Nimodipine