Neurohypophysial vasopressin and oxytocin as influenced by (6R)-5,6,7,8-tetrahydro-alpha-biopterin in euhydrated and dehydrated rats.
Experiments were performed to test a possible role of (6R)-5,6,7,8-tetrahydro-alpha-biopterin dihydrochloride (BH4) in the neurohypophysial vasopressin and oxytocin content in euhydrated and dehydrated rats. Chronic treatment with BH4, administered to not dehydrated animals, was followed by a significant decrease of neurohypophysial vasopressin, but not of neurohypophysial oxytocin. In dehydrated animals the neurohypophysial vasopressin content decreased progressively; this process was not affected significantly by BH4. In rats dehydrated and treated simultaneously with BH4 the decrease of neurohypophysial oxytocin content was distinctly less marked.
Ciosek
J
J
Department of Pathophysiology, University School of Medicine, Lodz, Poland.
Guzek
J W
JW
Orłowska-Majdak
M
M
D000818:Animals; D001708:Biopterins / Q000031:analogs & derivatives* / Q000494:pharmacology; D003681:Dehydration / Q000378:metabolism*; D008297:Male; D010121:Oxytocin / Q000378:metabolism*; D010904:Pituitary Gland, Posterior / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014667:Vasopressins / Q000378:metabolism*
D014667:Vasopressins; D001708:Biopterins; D010121:Oxytocin; C003402:sapropterin