Immunostimulant effects on granulocyte functions during an acute respiratory infection.
Treatment of healthy volunteers by Ribomunyl, whether or not in association with in vitro antibiotics (amoxicillin or josamycin), has been earlier demonstrated to be an efficient stimulant of PMN functions (adhesion and migration). This second double-blind study versus placebo was performed on 17 patients with acute respiratory infections (placebo group: eight subjects; Ribomunyl group: nine subjects). Ribomunyl treatment (four days) associated with antibiotherapy (amoxicillin) induced a significant increase of PMN adhesion (p = 0.014) with no significant effect of the placebo (p = 0.30) and no significant difference between the initial level of PMN adhesion of the two groups (placebo-Ribomunyl).
Roques
C
C
Faculté des Sciences Pharmaceutiques, Laboratoire de Microbiologie Industrielle et Virologie, Toulouse, France.
Frayret
M N
MN
Luc
J
J
Michel
G
G
Rouquet
R M
RM
Leophonte
P
P
Dutau
G
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000627:therapeutic use*; D000942:Antigens, Bacterial / Q000627:therapeutic use*; D002648:Child; D003131:Combined Modality Therapy; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000628:therapy*
D000942:Antigens, Bacterial; C034206:Ribomunyl; D000658:Amoxicillin