title: Increased plasma endothelin in NIDDM patients with retinopathy.
abstract: OBJECTIVE
  To elucidate the significance of ET in diabetic microvascular disease.
  
  
  METHODS
  We determined plasma levels of ir-ET-1 in 25 NIDDM patients without hypertension and/or renal dysfunction.
  
  
  RESULTS
  The plasma levels of ir-ET-1 in NIDDM patients with simple (n = 8) and proliferative (n = 8) retinopathy were 0.58 +/- 0.04 pM and 0.60 +/- 0.04 pM, respectively, which were significantly higher than those in normal, nondiabetic subjects (0.24 +/- 0.02 pM [n = 31]) and NIDDM patients without retinopathy (0.30 +/- 0.05 pM [n = 9]).
  
  
  CONCLUSIONS
  These results suggest that plasma ET-1 is related to diabetic microvascular disease.
authors.affiliation: Department of Medicine, Tokyo Women's Medical College, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kawamura
authors.forename: H
authors.initials: H
authors.lastname: Ohgawara
authors.forename: M
authors.initials: M
authors.lastname: Naruse
authors.forename: N
authors.initials: N
authors.lastname: Suzuki
authors.forename: N
authors.initials: N
authors.lastname: Iwasaki
authors.forename: K
authors.initials: K
authors.lastname: Naruse
authors.forename: S
authors.initials: S
authors.lastname: Hori
authors.forename: H
authors.initials: H
authors.lastname: Demura
authors.forename: Y
authors.initials: Y
authors.lastname: Omori
mesh_terms: D015415:Biomarkers / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003930:Diabetic Retinopathy / Q000097:blood*; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values
chemical_list: D015415:Biomarkers; D016232:Endothelins