title: Localization of the photoreceptor gene ROM1 to human chromosome 11 and mouse chromosome 19: sublocalization to human 11q13 between PGA and PYGM.
abstract: Rom-1 is a retinal integral membrane protein that, together with the product of the human retinal degeneration slow gene (RDS), defines a photoreceptor-specific protein family. The gene for rom-1 (HGM symbol: ROM1) has been assigned to human chromosome 11 and mouse chromosome 19 by Southern blot analysis of somatic cell hybrid DNAs. ROM1 was regionally sublocalized to human 11p13-11q13 by using three mouse-human somatic cell hybrids; in situ hybridization refined the sublocalization to human 11q13. Analysis of somatic cell hybrids suggested that the most likely localization of ROM1 is in the approximately 2-cM interval between human PGA (human pepsinogen A) and PYGM (muscle glycogen phosphorylase). ROM1 appears to be a new member of a conserved syntenic group whose members include such genes as CD5, CD20, and OSBP (oxysterol-binding protein), on human chromosome 11 and mouse chromosome 19. Localization of the ROM1 gene will permit the examination of its linkage to hereditary retinopathies in man and mouse.
authors.affiliation: Department of Genetics, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: R A
authors.initials: RA
authors.lastname: Bascom
authors.forename: J
authors.initials: J
authors.lastname: García-Heras
authors.forename: C L
authors.initials: CL
authors.lastname: Hsieh
authors.forename: D S
authors.initials: DS
authors.lastname: Gerhard
authors.forename: C
authors.initials: C
authors.lastname: Jones
authors.forename: U
authors.initials: U
authors.lastname: Francke
authors.forename: H F
authors.initials: HF
authors.lastname: Willard
authors.forename: D H
authors.initials: DH
authors.lastname: Ledbetter
authors.forename: R R
authors.initials: RR
authors.lastname: McInnes
mesh_terms: D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D005136:Eye Proteins / Q000235:genetics*; D005260:Female; D006801:Humans; D006822:Hybrid Cells; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D010435:Pepsinogens / Q000235:genetics*; D006005:Phosphorylases / Q000235:genetics*
chemical_list: D005136:Eye Proteins; D008565:Membrane Proteins; D010435:Pepsinogens; D006005:Phosphorylases