PEO enhancement of platelet deposition, fibrinogen deposition, and complement C3 activation.
Whereas it has been commonly thought that adding polyethylene oxide PEO to a surface would diminish the capacity of the surface to cause deposition of platelets and of fibrinogen, and to activate complement C3, we present data showing exactly the opposite. These unexpected results are obtained with low molecular weight (2000) PEO, and are not found with higher molecular weight (20,000) PEO.
Chaikof
E L
EL
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge 02139.
Merrill
E W
EW
Callow
A D
AD
Connolly
R J
RJ
Verdon
S L
SL
Ramberg
K
K
D000818:Animals; D003167:Complement Activation; D003176:Complement C3 / Q000502:physiology*; D005340:Fibrinogen / Q000502:physiology*; D008855:Microscopy, Electron, Scanning; D008970:Molecular Weight; D010215:Papio; D010973:Platelet Adhesiveness / Q000502:physiology*; D011092:Polyethylene Glycols / Q000737:chemistry*; D013499:Surface Properties
D003176:Complement C3; D011092:Polyethylene Glycols; D005340:Fibrinogen