[Potential possibilities of using adrenergic beta blockers in chronic heart failure].
The study was undertaken to examine the efficacy of beta-adrenoblockers used in 26 patients with chronic heart failure which had been caused by coronary heart disease in 12 patients, by rheumatic heart disease in 8 patients, by dilated cardiomyopathy in 5 patients, and by chronic myocarditis in 1 patient. beta-Blockers such as oxprenolol, propranolol, and metoprolol were supplemented to the therapy of the patients with chronic heart failure who were resistant to cardiac glycosides, diuretics, and vasodilators. This resulted in functional class improvement by the New York Heart Association from 3.67 +/- 0.1 to 2.29 +/- 0.1. The authors defined the following predictors of the efficacy of beta-blockers in chronic heart failure: duration of the disease, diastolic pressure, cardiac rhythm, and left ventricular ejection fraction and discussed the mechanisms responsible for their positive effect in chronic heart failure.
Lopatin
Iu M
IuM
Ghani
P
P
Sinitsin
V E
VE
Mareev
V Iu
VIu
D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use*; D008875:Middle Aged; D010096:Oxprenolol / Q000627:therapeutic use*; D011379:Prognosis; D011433:Propranolol / Q000627:therapeutic use*
D010096:Oxprenolol; D011433:Propranolol; D008790:Metoprolol
Potentsial'nye vozmozhnosti primeneniia beta-adrenoblokatorov pri khronicheskoĭ serdechnoĭ nedostatochnosti.