title: Immunogenicity and reactogenicity of Takeda acellular pertussis-component diphtheria-tetanus-pertussis vaccine in 2- and 3-month-old children in Japan.
abstract: OBJECTIVE
  To compare the reactogenicity and immune response to the Takeda acellular pertussis-component diphtheria-tetanus-pertussis (APDT) vaccine in children when immunization commenced at 2 months (group A) vs 3 months (group B) of age.
  
  
  METHODS
  Longitudinal, nonblinded, comparative study.
  
  
  METHODS
  Pediatric well-child clinics.
  
  
  METHODS
  Healthy 50- to 98-day-old infants.
  
  
  RESULTS
  Good antibody responses to lymphocytosis-promoting factor, filamentous hemagglutinin, agglutinogens, and pertactin occurred in both age groups after both the third and fourth vaccine doses. Both young age and transplacentally acquired maternal antibody independently and together have a suppressive effect on the response to the four antigens in this APDT vaccine. However, these effects appear to be minor. Vaccine reactions were mild; group A children had slightly but not significantly higher rates than group B children.
  
  
  CONCLUSIONS
  The present US diphtheria and tetanus toxoids and pertussis vaccine immunization schedule should also be satisfactory with this acellular pertussis component vaccine.
authors.affiliation: Mie National Hospital, Tsu, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kamiya
authors.forename: R
authors.initials: R
authors.lastname: Nii
authors.forename: T
authors.initials: T
authors.lastname: Matsuda
authors.forename: N
authors.initials: N
authors.lastname: Yasuda
authors.forename: P D
authors.initials: PD
authors.lastname: Christenson
authors.forename: J D
authors.initials: JD
authors.lastname: Cherry
mesh_terms: D000367:Age Factors; D000917:Antibody Formation; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D003875:Drug Eruptions / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D007115:Immunization Schedule; D015994:Incidence; D007223:Infant; D007564:Japan / Q000453:epidemiology; D008137:Longitudinal Studies
chemical_list: D015721:Diphtheria-Tetanus-Pertussis Vaccine