title: Further observations on serial serum immunoreactive inhibin levels in the luteal phase and early gestation after ovarian stimulation for in vitro fertilization and embryo transfer.
abstract: Serum immunoreactive inhibin of the luteal phase was measured by radioimmunoassay in 71 patients in vitro fertilization and embryo transfer (IVF-ET). The correlation between the pregnancy outcome and the serial inhibin pattern from the luteal phase to early gestation was studied. In nonconception cycles (n = 35), serum inhibin concentration rose and reached a peak level around 5 or 6 days after oocyte pick-up (OPU), then fell to the level of the early follicular phase. In conception cycles (n = 22), serum inhibin levels rose again 10-15 days after OPU. Serum inhibin levels were significantly higher from 10 days after OPU in multiple pregnancy (n = 5) than in single pregnancy (n = 17). In viable single pregnancy (n = 17), serum inhibin levels were significantly higher than in non-viable pregnancy (n = 14) from 15 days after OPU. Serum inhibin levels in early gestation correlated well with the pregnancy outcome of IVF-ET. These data suggest that inhibin is an important factor for the diagnosis of pregnancy outcome.
authors.affiliation: Department of Obstetrics and Gynecology, Gunma University School of Medicine, Maebashi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
authors.forename: M
authors.initials: M
authors.lastname: Seki
authors.forename: Y
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: K
authors.initials: K
authors.lastname: Tsuchiya
authors.forename: M
authors.initials: M
authors.lastname: Itoh
authors.forename: I
authors.initials: I
authors.lastname: Itoh
authors.forename: H
authors.initials: H
authors.lastname: Shinozaki
authors.forename: T
authors.initials: T
authors.lastname: Jujo
authors.forename: Y
authors.initials: Y
authors.lastname: Ibuki
authors.forename: M
authors.initials: M
authors.lastname: Igarashi
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood; D006063:Chorionic Gonadotropin / Q000097:blood; D004624:Embryo Transfer; D004967:Estrogens / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007265:Inhibins / Q000097:blood* / Q000276:immunology; D008183:Luteal Phase / Q000502:physiology*; D011247:Pregnancy / Q000097:blood*; D011261:Pregnancy Trimester, First; D011271:Pregnancy, Ectopic / Q000097:blood; D011272:Pregnancy, Multiple / Q000097:blood; D011374:Progesterone / Q000097:blood; D011863:Radioimmunoassay; D014427:Twins
chemical_list: D006063:Chorionic Gonadotropin; D004967:Estrogens; D011374:Progesterone; D007265:Inhibins