title: Stability of long-term renal function in heart transplant patients treated with induction therapy and low-dose cyclosporine.
abstract: Long-term renal function was evaluated in heart transplant recipients who were treated with antilymphocyte globulin induction therapy and low-dose cyclosporine therapy. Although an initial 16% drop in the glomerular filtration rate occurred, long-term follow-up revealed stability of renal function. Four-year patient survival was 77.6%. Use of induction therapy with low-dose cyclosporine may preserve renal function without compromising long-term patient survival.
authors.affiliation: Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas.
authors.forename: T A
authors.initials: TA
authors.lastname: Gonwa
authors.forename: M L
authors.initials: ML
authors.lastname: Mai
authors.forename: J
authors.initials: J
authors.lastname: Pilcher
authors.forename: C
authors.initials: C
authors.lastname: Johnson
authors.forename: S
authors.initials: S
authors.lastname: Pierson
authors.forename: J E
authors.initials: JE
authors.lastname: Capehart
authors.forename: P A
authors.initials: PA
authors.lastname: Alivizatos
mesh_terms: D000961:Antilymphocyte Serum / Q000627:therapeutic use*; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects*; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000187:drug effects; D016027:Heart Transplantation; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000502:physiology
chemical_list: D000961:Antilymphocyte Serum; D016572:Cyclosporine; D003404:Creatinine