title: [Color-coded duplex sonography and ultrasound contrast medium in the study of peripheral arteries--initial clinical experiences].
abstract: Ultrasound contrast agents (US-CA) amplify reflected sound waves. Most substances used as contrast agents are destroyed when passing the lungs. SH U 508 is a new US-CA that can pass the lungs without impairment after peripheral intravenous application. In a clinical trial of this US-CA, we investigated its effect on the visualization of blood movement in peripheral arteries by color-coded Duplex sonography (CCDS). The leg arteries of 20 patients with severe chronic arterial occlusion were examined by CCDS (QAD I and Platinum) after i.v. application of the US-CA. After passage of the pulmonary capillaries, the US-CA amplified blood flow signals in the arterial system in a dose-dependent manner with both systems used. Undesired side-effects were not observed. The amplification produced by appropriate concentrations of the US-CA markedly improved the visualization of blood movement. Further studies are required to determine the optimal dosage and application technique as well as the indication for using this US-CA.
authors.affiliation: Klinikum Steglitz, Radiologische Klinik und Poliklinik, Abteilung für Radiologische Diagnostik und Nuklearmedizin, FU, Berlin.
authors.forename: F
authors.initials: F
authors.lastname: Fobbe
authors.forename: I
authors.initials: I
authors.lastname: Ohnesorge
authors.forename: M
authors.initials: M
authors.lastname: Reichel
authors.forename: P
authors.initials: P
authors.lastname: Dollinger
authors.forename: R
authors.initials: R
authors.lastname: Schürmann
authors.forename: K J
authors.initials: KJ
authors.lastname: Wolf
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001157:Arterial Occlusive Diseases / Q000000981:diagnostic imaging*; D001783:Blood Flow Velocity / Q000502:physiology; D003287:Contrast Media; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D008297:Male; D008875:Middle Aged; D011134:Polysaccharides; D014463:Ultrasonography / Q000295:instrumentation*
chemical_list: D003287:Contrast Media; D011134:Polysaccharides; C059891:SHU 508
vernacular_title: Farbkodierte Duplexsonographie und Ultraschallkontrastmittel zur Untersuchung peripherer Arterien--Erste klinische Erfahrungen.