title: [Activity of cytochromes P-450p and P-450h in liver microsomes and blood corticosteroid levels in experimental animals under the action of physical factors].
abstract: In experiments on male Wistar rats it has been found that physical factors applied in medicine (laser radiation of low intensity with wave length 0.89 microns, microwaves of centimeter range of 2450 MHz, and ultrasound of low intensity 880 KHz) changed catalytic activity of liver microsomal and rostenedione 16 alpha- and 6 beta-hydroxylating cytochromes P-450h and P-450p and blood corticosteroids level. Activities of these two steroid-metabolizing cytochromes decreased under ultrasonic skin application on liver region and increased under microwave and laser action. Contents of physiologically inactive form of corticosterone were not changed by the physical factors action while level of active hormone was increased under ultrasonic and microwave action. These findings suggest association of the activity of liver steroid-metabolizing cytochromes P-450 and level of physiologically active form of corticosterone in blood under physical factors skin application on liver region.
authors.forename: T A
authors.initials: TA
authors.lastname: Zolotareva
authors.forename: G A
authors.initials: GA
authors.lastname: Gorchakova
authors.forename: V L
authors.initials: VL
authors.lastname: Konovalenko
authors.forename: L N
authors.initials: LN
authors.lastname: Konovalenko
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Grishanova
authors.forename: L F
authors.initials: LF
authors.lastname: Guliaeva
authors.forename: V V
authors.initials: VV
authors.lastname: Liakhovich
mesh_terms: D000305:Adrenal Cortex Hormones / Q000097:blood*; D000818:Animals; D003345:Corticosterone / Q000097:blood; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D007527:Isoenzymes / Q000378:metabolism*; D007834:Lasers; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D008872:Microwaves; D051381:Rats; D017208:Rats, Wistar; D014465:Ultrasonics
chemical_list: D000305:Adrenal Cortex Hormones; D007527:Isoenzymes; D003577:Cytochrome P-450 Enzyme System; D003345:Corticosterone
vernacular_title: Aktivnost' tsitokhromov P-450p i P-450h mikrosom pecheni i uroven' kortikosteroĭdov v krovi éksperimental'nykh zhivotnykh v usloviiakh vozdeĭstviia fizicheskimi faktorami.