[The effect of a new drug form for the intravenous administration of vitamin K1 on the blood coagulation system].
In rabbits with experimental hypocoagulation induced by phenylin, the use of a new dosage form of vitamin K1 for intravenous injections in does of 1 and 5 mg/kg led, in contrast to vicasol in a dose of 0.4 mg/kg, to an increase of the prothrombin index after 2 hours and to its complete normalization after 4 hours. Intravenous injection of vitamin K1 into intact animals did not entail any changes in the activated partial thromboplastin time, thrombin and prothrombin time, in the content of fibrinogen and products of its biotransformation, antithrombin III activity, and fibrinolytic activity or in the count of platelets and their aggregation capacity.
Belozerskaia
G G
GG
Makarov
V A
VA
Petrukhina
G N
GN
Samoĭlov
A V
AV
Kamaev
N O
NO
Seĭfulla
R D
RD
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001778:Blood Coagulation Disorders / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005342:Fibrinolysis / Q000187:drug effects; D006490:Hemostatics / Q000008:administration & dosage; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D010630:Phenindione; D011517:Prothrombin Time; D011817:Rabbits; D014812:Vitamin K / Q000008:administration & dosage / Q000031:analogs & derivatives; D010837:Vitamin K 1 / Q000008:administration & dosage*; D024483:Vitamin K 3
D006490:Hemostatics; D014812:Vitamin K; D010630:Phenindione; D024483:Vitamin K 3; D010837:Vitamin K 1
Vliianie novoĭ lekarstvennoĭ formy dlia vnutrivennogo vvedeniia vitamina K1 na svertyvaiushchuiu sistemu krovi.