Sperm chromosome analysis of two males heterozygous for a t(2;17)(q35;p13) and t(3;8)(p13;p21) reciprocal translocation.
Sperm chromosome complements from two males, one heterozygous for the reciprocal translocation t(2;17)(q35;p13) (n = 18) and one for t(3;8) (p13;p21) (n = 73), were analyzed. Only 2:2 segregations were observed with t(2;17): alternate, 56%; adjacent-I, 33%; adjacent-II, 11%. Both 2:2 and 3:1 meiotic segregations occurred in t(3;8): alternate, 34.2%; adjacent-I, 43.8%; adjacent-II, 20.5% and 3:1, 1.4%. A significant excess of chromosomally normal versus balanced sperm complements was observed with both translocation heterozygotes. The frequencies of other chromosome aberrations unrelated to the translocations were 16.7% for t(2;17) and 8.2% for t(3;8). The ratio of X-bearing to Y-bearing sperm was not different from the theoretically expected ratio of 1:1.
Jenderny
J
J
Institut für Humangenetik und Anthropologie, Universität, Düsseldorf, Federal Republic of Germany.
D000328:Adult; D002886:Chromosomes, Human, Pair 17; D002889:Chromosomes, Human, Pair 2; D002893:Chromosomes, Human, Pair 3; D002898:Chromosomes, Human, Pair 8; D006579:Heterozygote; D006801:Humans; D008297:Male; D013094:Spermatozoa; D014178:Translocation, Genetic / Q000235:genetics*