Partition of piperidinoethylesters of 2-alkyloxyphenylcarbamic acid in unilamellar phosphatidylcholine liposomes.
Molar partition coefficients for amphiphilic N-[2-(2-alkyl-oxyphenyl-carbamoyloxy)-ethyl]-piperidinium chlorides (PAA) between small unilamellar egg yolk phosphatidyl choline liposomes and saline, as determined by ultraviolet difference spectroscopy at 22 degrees C, pH 5-6, v = 34640 cm-1, and at 100 mumol/l PAA concentration, were 149, 1990, and 7474 for PAA with 5, 7, and 9 carbon atoms in the alkyloxy substituent, respectively. At the PAA concentration used, the cut-off in biological activities of PAAs with long alkyloxy substituents could not be caused by the self-association of PAA molecules in the aqueous phase.
Balgavý
P
P
Faculty of Pharmacy, J. A. Comenius University, Bratislava, Czechoslovakia.
Benedikovic
I
I
Kopecká
B
B
Gallová
J
J
D002219:Carbamates / Q000737:chemistry*; D004952:Esters; D008081:Liposomes; D010713:Phosphatidylcholines; D010880:Piperidines / Q000737:chemistry*; D013329:Structure-Activity Relationship
D002219:Carbamates; D004952:Esters; D008081:Liposomes; D010713:Phosphatidylcholines; D010880:Piperidines