DNA markers in diagnosis of adult dominant polycystic kidney disease.
We report the results of a biological and molecular study carried out on 11 Italian families, with a total of 111 individuals in which adult dominant polycystic kidney disease segregates. A restriction fragment length polymorphism analysis was performed. Two families have shown a genetic heterogeneity even if not phenotypically different from the other ones: they resulted unlinked to 16p markers. A prenatal diagnosis has been performed in a family of the linked type.
Veneziano
L
L
Dipartimento di Biologia, Università Tor Vergata, Roma, Italia.
D'Angelo
A R
AR
Burrai
L
L
Perugia
G
G
Gentile
V
V
Potenza
L
L
Iampieri
M P
MP
Novelletto
A
A
Novelli
G
G
Frontali
M
M
D004247:DNA / Q000032:analysis*; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D010375:Pedigree; D016891:Polycystic Kidney, Autosomal Dominant / Q000175:diagnosis* / Q000235:genetics; D011110:Polymorphism, Genetic; D011296:Prenatal Diagnosis
D005819:Genetic Markers; D004247:DNA