Insulin requirements in insulin-dependent and insulin-requiring GDM women during final month of pregnancy.
OBJECTIVE
To determine the significance of falling insulin requirements after the 36th wk of gestation in insulin-requiring pregnant women.


METHODS
Insulin requirements of women with IDDM and IRGDM were assessed from the 36th wk of pregnancy, with evaluation of maternal characteristics and fetal outcomes.


RESULTS
In 32 pregnancies of women with IDDM, there was a 5 +/- 2% decrease in insulin requirements, and in 19 pregnancies of women with IRGDM, there was a 28 +/- 10% increase. Of the 62% of women whose insulin requirements declined, the decrement was 12 +/- 2% and was associated with longer duration of diabetes (12 +/- 2 vs. 6 +/- 1 yr, P less than 0.05) but not with age, prepregnancy BMI, weight gain, or maternal or fetal complications. Only 3 pregnancies in IRGDM women were associated with a decrease in insulin requirements. Although maternal parameters were no different from those with IDDM, infants born to women with IRGDM were smaller (3531 +/- 123 vs. 3874 +/- 94 g, P less than 0.005).


CONCLUSIONS
Insulin requirements from the 36th wk of gestation commonly decreased in women with IDDM, associated with longer duration of diabetes but did not carry any adverse prognostic indication for the infants. Women with IRGDM experienced a continual increase in insulin requirements over the final weeks of pregnancy.
McManus
R M
RM
Division of Endocrinology and Metabolism, University of Alberta, Edmonton, Canada.
Ryan
E A
EA
D000328:Adult; D001663:Bilirubin / Q000097:blood; D001724:Birth Weight; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D016640:Diabetes, Gestational / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000453:epidemiology; D007003:Hypoglycemia / Q000453:epidemiology; D007231:Infant, Newborn; D007328:Insulin / Q000627:therapeutic use*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000188:drug therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome; D015430:Weight Gain
D007328:Insulin; D001663:Bilirubin