Uveitis, a presenting symptom of malignant histiocytosis.
A patient presenting initially with bilateral uveitis was admitted 6 weeks later to the Department of Internal Medicine "A" because of fever, chills, and pancytopenia. Physical examination, ultrasonography and CT scan revealed hepatosplenomegaly only, without lymphadenopathy. A bone marrow trephine biopsy showed areas with a dense infiltrate of abnormal cells, displaying many mitotic figures. Some of the cells resembled better differentiated histiocytes and contained hemosiderin pigment or phagocytosed erythrocytes. Immunohistological tests confirmed the diagnosis of malignant histiocytosis (MH). A survey of the literature revealed two other cases with uveitis and MH.
Schifter
T
T
Department of Medicine, Hasharon Hospital, Golda Medical Center, Petah-Tiqva, Israel.
Gal
R
R
Deutsch
D
D
Lewinski
U H
UH
D000208:Acute Disease; D054747:Histiocytic Sarcoma / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000209:etiology*; D014605:Uveitis / Q000209:etiology*