[Disposition analysis by fast inverse Laplace transform (FILT)].
A curve fitting program, MULTI (FILT), in which an algorithm of fast inverse Laplace transform is incorporated, was introduced into the area of drug disposition. The reliance of MULTI (FILT) was verified by the Monte Carlo simulation based on compartment models. MULTI (FILT) was applied to the analysis of the local dispositions of drugs through the liver, including the construction of new dispersion model, the effect of albumin in perfusate, and the effect of perfusion rate. The elimination in the lung and the enterohepatic circulation were also evaluated using MULTI (FILT) in a simple manner.
Yamaoka
K
K
Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
D003198:Computer Simulation; D004764:Enterohepatic Circulation / Q000502:physiology; D008962:Models, Theoretical; D010599:Pharmacokinetics