title: Fulminant endocarditis due to infection with penicillinase-producing Neisseria gonorrhoeae.
abstract: Endocarditis is a rare but potentially lethal manifestation of gonococcal infection. We report the case of a patient with fulminant endocarditis secondary to infection with penicillinase-producing Neisseria gonorrhoeae (PPNG). The patient had rapid deterioration from extensive destruction of the aortic valve with abscess and fistula formation. Lifesaving emergency surgery was performed. To our knowledge this is the first reported case of gonococcal endocarditis secondary to infection with a penicillinase-producing organism.
authors.affiliation: Department of Internal Medicine (Infectious Disease Division), Naval Hospital, San Diego, CA 92134-5000.
authors.forename: P J
authors.initials: PJ
authors.lastname: Weiss
authors.forename: C A
authors.initials: CA
authors.lastname: Kennedy
authors.forename: D F
authors.initials: DF
authors.lastname: McCann
authors.forename: H E
authors.initials: HE
authors.lastname: Hill
authors.forename: E C
authors.initials: EC
authors.lastname: Oldfield
mesh_terms: D000328:Adult; D001018:Aortic Diseases / Q000209:etiology; D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology*; D004697:Endocarditis, Bacterial / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D005402:Fistula / Q000209:etiology; D006069:Gonorrhea / Q000188:drug therapy / Q000382:microbiology*; D006325:Heart Atria; D006331:Heart Diseases / Q000209:etiology; D006801:Humans; D008297:Male; D009344:Neisseria gonorrhoeae / Q000201:enzymology / Q000302:isolation & purification; D010405:Penicillinase / Q000378:metabolism
chemical_list: D010405:Penicillinase