The stretched ventricle. Myocardial creep and contractile dysfunction after acute nonischemic ventricular distention.
The hypothesis that nonischemic distention of the arrested, flaccid ventricle causes myocardial creep and reduces ventricular contractile force was tested in 16 sheep. Left ventricular volume was calculated from ultrasonic dimension transducers spanning left ventricular major and minor axes and left ventricular wall thickness. Changes in left ventricular volume were plotted against left ventricular pressure, with and without temporary occlusion of both venae cavae before and after nonischemic distention of the continuously perfused, flaccid nonbeating left ventricle arrested with oxygenated, normothermic blood-potassium perfusate. During 12 minutes of cardiac arrest, an apical balloon progressively distended the left ventricle to a peak pressure of 40 mm Hg in 11 sheep using a protocol designed to prevent subendocardial ischemia or mechanical injury. Coronary sinus lactate measurements and myocardial distribution of microspheres confirmed the absence of ischemia in 16 animals. In five control sheep the balloon was inserted but not inflated. Left ventricular volume at zero pressure increased from 5.9 +/- 3.5 to 9.5 +/- 4.4 ml (p < 0.05) after balloon inflation and did not change in the control animals. After maximum distention of the balloon, static left ventricular volumes at identical pressures were significantly greater. After passive distention, the slope of the end-systolic pressure-volume relationship, a measure of contractility, decreased significantly (p < 0.05) from 7.1 +/- 2.8 to 3.5 +/- 1.8 mm Hg/ml and did not change in the control group. Passive distention ("stretching") of the nonischemic flaccid left ventricle thus causes myocardial creep and reduces ventricular contractility.
Downing
S W
SW
Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia.
Savage
E B
EB
Streicher
J S
JS
Bogen
D K
DK
Tyson
G S
GS
Edmunds
L H
LH
D000818:Animals; D002306:Cardiac Volume; D003971:Diastole; D004106:Dilatation; D006324:Heart Arrest, Induced; D006439:Hemodynamics; D009200:Myocardial Contraction; D011312:Pressure; D012756:Sheep; D013314:Stress, Mechanical; D016277:Ventricular Function, Left