title: Mechanism of genital transmission of SIV: a hypothesis based on transmission studies and the location of SIV in the genital tract of chronically infected female rhesus macaques.
abstract: To understand the biologic processes involved in transmission of HIV, we examined the genital tracts of chronically infected female macaques and localized SIV-infected cells. SIV was found in the genital tract of 12 of 16 animals and SIV-infected cells were located in the cervix and vagina. Inoculation of cell-free SIV into the blind vaginal pouch of hysterectomized macaques resulted in systemic infection. We propose a hypothesis to explain the early events in the genital transmission of SIV.
authors.affiliation: California Regional Primate Research Center, University of California, Davis 95616.
authors.forename: C J
authors.initials: CJ
authors.lastname: Miller
authors.forename: N J
authors.initials: NJ
authors.lastname: Alexander
authors.forename: P
authors.initials: P
authors.lastname: Vogel
authors.forename: J
authors.initials: J
authors.lastname: Anderson
authors.forename: P A
authors.initials: PA
authors.lastname: Marx
mesh_terms: D000818:Animals; D002584:Cervix Uteri / Q000382:microbiology; D004195:Disease Models, Animal; D005260:Female; D005836:Genitalia, Female / Q000382:microbiology*; D007150:Immunohistochemistry; D008253:Macaca mulatta; D009693:Nucleic Acid Hybridization; D012367:RNA, Viral / Q000032:analysis; D016097:Simian Acquired Immunodeficiency Syndrome / Q000635:transmission*; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000302:isolation & purification*; D014621:Vagina / Q000382:microbiology; D014766:Viremia / Q000662:veterinary
chemical_list: D012367:RNA, Viral