title: [Effects of treatment of arrhythmias requiring therapy in dilated cardiomyopathy with amiodarone on alpha human atrial natriuretic peptide].
abstract: In a longitudinal study comprising a total of 18 patients, the paradoxical time course of hANP plasma levels, i.e. the reproducibility of the low levels previously reported in cases of extreme cardiac insufficiency after administration of amiodarone, was investigated over a period of 9 months. At the same time, the effect of the degree of cardiac insufficiency and arrhythmia on the secretion of hANP was observed. The patients had been admitted to hospital because of the diagnoses "cardiac insufficiency secondary to cardiomyopathy" or "Grade IVb arrhythmia according to Lown's classification". During in-patient treatment, antiarrhythmic therapy was commenced in all patients. Clinical examinations and determinations of humoral parameters during therapy showed a substantial number of patients, who exhibited no increase in hANP levels despite massive cardiac decompensation. As far as drug therapy of patients with severe arrhythmias secondary to congestive (dilated) cardiomyopathy is concerned, amiodarone has proved to be the drug of choice in combination with digitalis, ACE inhibitors and diuretics. There is a close correlation between the degree of cardiac insufficiency and plasma hANP levels.
authors.affiliation: Medizinischen Abteilung, Landeskrankenhauses Bad Radkersburg.
authors.forename: B
authors.initials: B
authors.lastname: Zirm
authors.forename: A
authors.initials: A
authors.lastname: Zirm
authors.forename: R
authors.initials: R
authors.lastname: Kargl
authors.forename: E
authors.initials: E
authors.lastname: Hartter
mesh_terms: D000368:Aged; D000450:Aldosterone / Q000097:blood; D000638:Amiodarone / Q000627:therapeutic use*; D001127:Arginine Vasopressin / Q000097:blood; D001145:Arrhythmias, Cardiac / Q000097:blood / Q000188:drug therapy*; D009320:Atrial Natriuretic Factor / Q000097:blood*; D002216:Captopril / Q000627:therapeutic use; D002311:Cardiomyopathy, Dilated / Q000097:blood / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D015716:Electrocardiography, Ambulatory / Q000187:drug effects; D004656:Enalapril / Q000627:therapeutic use; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged
chemical_list: D001127:Arginine Vasopressin; D000450:Aldosterone; D004656:Enalapril; D009320:Atrial Natriuretic Factor; D002216:Captopril; D000638:Amiodarone
vernacular_title: Auswirkungen der Behandlung therapiepflichtiger Arrhythmien bei dilatativer CMP mit Amiodaron auf das alpha-humane atriale natriuretische Peptid (alpha-hANP).