Maternal coagulation inhibitors and the effects of cesarean delivery.
Maternal hypercoagulability in normal pregnancy results from significant increases in blood factors that promote thrombosis or decreases in factors that inhibit thrombosis, such as antithrombin III (AT-III) and proteins C and S. The precise role of these factors in puerperal hemostasis is not clear. In 10 normal, pregnant women at term undergoing scheduled repeat cesarean section, the percent activities of AT-III, proteins C and S, and C4b-binding protein were determined in peripheral venous blood preoperatively and in samples of uterine venous blood before the uterine incision was made and 5 and 15 minutes after placental delivery using the Laurell Rocket electroimmunodiffusion technique. The mean percent activities of AT-III (73%), protein S (81%) and C4b-binding protein (85%) were lower than those in nonpregnant controls, were similar in peripheral and uterine venous blood and were unchanged after placental delivery. These data suggest that such factors may not play an important role in acute uteroplacental hemostasis during normal pregnancy.
Banias
B B
BB
Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta 30912-3345.
Nolan
T E
TE
Devoe
L D
LD
Krauss
J S
JS
D000990:Antithrombin III / Q000032:analysis; D001779:Blood Coagulation Factors / Q000037:antagonists & inhibitors*; D001798:Blood Proteins / Q000032:analysis*; D002352:Carrier Proteins / Q000097:blood; D002585:Cesarean Section; D015935:Complement C4b / Q000032:analysis; D003169:Complement Inactivator Proteins; D005260:Female; D006023:Glycoproteins; D006801:Humans; D011247:Pregnancy; D011486:Protein C / Q000032:analysis; D014599:Uterus / Q000098:blood supply; D014680:Veins
D001779:Blood Coagulation Factors; D001798:Blood Proteins; D002352:Carrier Proteins; D003169:Complement Inactivator Proteins; D006023:Glycoproteins; D011486:Protein C; D015935:Complement C4b; D000990:Antithrombin III