Quinobene, a new potent anti-HIV agent.
A simple synthesis of the sulfonated azo dye Quinobene (3) and its derivatives, as well as the results of their evaluation in anti-HIV screening have been described. Thus, reacting the diazonium salt of 4,4'-diaminostilbene-2,2'-disulfonic acid with 8-hydroxyquinoline-5-sulfonic acid yielded the readily isolable title compound. The lithium and tetramethylammonium salts of Quinobene and its complexes with Cu(II), Zn(II), Mg(II) were also prepared. In vitro tests showed considerable activity of these compounds against HIV-1.
Gruszecka-Kowalik
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School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta 30332.
Haugwitz
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Zalkow
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D000998:Antiviral Agents / Q000737:chemistry; D001391:Azo Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D002478:Cells, Cultured; D002614:Chelating Agents / Q000494:pharmacology; D006678:HIV / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D013267:Stilbenes / Q000138:chemical synthesis / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D001391:Azo Compounds; D002614:Chelating Agents; D013267:Stilbenes; C076933:quinobene