title: Pharmacokinetic study of tolmetin in the rat.
abstract: The pharmacokinetics of tolmetin (CAS 26171-23-3) was studied in male Wistar rats after intravenous and oral administration of 32.95 mg/kg. After intravenous administration of the drug, it was shown that the most probable model was the two-compartment-open model with Michaelis-Menten elimination. After oral administration, the drug was absorbed rapidly (K01 = 0.1304 min-1). The bioavailability was 96.94% and the drug was mostly excreted as 1-methyl-5-(4-carboxybenzoyl)-1H-pyrrole-2-acetic acid, while the excretion of the unchanged drug was 6.12%.
authors.affiliation: Research Department of Aldo-Union Laboratories, Esplugues, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Sabater
authors.forename: J
authors.initials: J
authors.lastname: Domenéch
authors.forename: R
authors.initials: R
authors.lastname: Obach
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D007275:Injections, Intravenous; D008297:Male; D008954:Models, Biological; D051381:Rats; D017208:Rats, Wistar; D014046:Tolmetin / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D014046:Tolmetin