New cytotoxic scalarane sesterterpenes from the Dictyoceratid sponge Strepsichordaia lendenfeldi.
Nine sesterterpenes 1-9 have been isolated from a Dictyoceratid sponge, Strepsichordaia lendenfeldi, collected on the Great Barrier Reef, Australia. Seven of these compounds are new, one [4] had been reported previously as a semisynthetic product, and one [5] had been isolated previously from Carteriospongia foliascens. Unambiguous 13C- and 1H-nmr assignments have been made for 1 based on extensive 1D and 2D high field nmr experiments, which enabled 13C-nmr assignments to be made for 2-9. Significant growth inhibitory effects with tested cancer cell lines are reported for compounds 1-8.
Bowden
B F
BF
Department of Chemistry and Biochemistry, James Cook University of North Queensland, Townsville, Australia.
Coll
J C
JC
Li
H
H
Cambie
R C
RC
Kernan
M R
MR
Bergquist
P R
PR
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006801:Humans; D051379:Mice; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes; D013729:Terpenes / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D054830:Sesterterpenes; D013729:Terpenes