title: [Three cases of acute methamphetamine intoxication--analysis of optically active methamphetamine].
abstract: Three typical cases of acute methamphetamine intoxication are reported. The concentrations of methamphetamine in the blood were 27.2, 6.43 and 0.60 micrograms/ml, respectively. All three victims had been exposed to high temperature in a bathroom or a closed room in summer at the time of death. Macroscopic autopsy revealed hemorrhagic pulmonary edema, and histologically, diffuse contraction-band necrosis was evident in the myocardium in all cases. The absolute structures of six illegally available methamphetamine showed an (S)-configuration with an optical purity of > 99% in enantiomeric excess and four were racemic form.
authors.affiliation: Department of Legal Medicine School of Medicine, Teikyo University.
authors.forename: A
authors.initials: A
authors.lastname: Mori
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: I
authors.initials: I
authors.lastname: Ishiyama
mesh_terms: D000328:Adult; D005260:Female; D005334:Fever / Q000473:pathology; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000032:analysis* / Q000506:poisoning*; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D011654:Pulmonary Edema / Q000473:pathology; D013237:Stereoisomerism
chemical_list: D008694:Methamphetamine