Discovery of a novel class of orally active, non-peptide angiotensin II antagonists.
De
B
B
Abbott Laboratories, Pharmaceutical Products Division, Abbott Park, Illinois 60064.
Winn
M
M
Zydowsky
T M
TM
Kerkman
D J
DJ
DeBernardis
J F
JF
Lee
J
J
Buckner
S
S
Warner
R
R
Brune
M
M
Hancock
A
A
D000284:Administration, Oral; D000804:Angiotensin II / Q000037:antagonists & inhibitors*; D000818:Animals; D001713:Biphenyl Compounds / Q000008:administration & dosage / Q000138:chemical synthesis / Q000493:pharmacokinetics; D007093:Imidazoles / Q000008:administration & dosage / Q000138:chemical synthesis / Q000493:pharmacokinetics; D019808:Losartan; D011743:Pyrimidines / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D051381:Rats; D011918:Rats, Inbred SHR; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship; D013777:Tetrazoles / Q000008:administration & dosage / Q000138:chemical synthesis / Q000493:pharmacokinetics
D001713:Biphenyl Compounds; D007093:Imidazoles; D011743:Pyrimidines; D013777:Tetrazoles; D000804:Angiotensin II; D019808:Losartan