Dietary restriction decreases thiobarbituric acid-reactive substances generation in the small intestine and in the liver of young rats.
This study investigated the influence of dietary restriction on thiobarbituric acid-reactive substances (TBARS) contents and on the intracellular antioxidant defence system in the small intestine or liver of young rats. Four weeks of diet restriction (-40%) lowered the TBARS level in both organs. No variations were found for the superoxide dismutase and catalase activities; only liver seleno-dependent glutathione peroxidase was enhanced by the restriction. The protection appeared more marked in the intestine than in the liver, and would be dependent on glutathione concentration.
Albrecht
R
R
Conservatoire National des Arts et Métiers (C.N.A.M), Laboratoire de Biologie, Paris, France.
Pelissier
M A
MA
Atteba
S
S
Smaili
M
M
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001835:Body Weight; D002374:Catalase / Q000378:metabolism; D005508:Food Deprivation / Q000502:physiology*; D005978:Glutathione / Q000378:metabolism; D007421:Intestine, Small / Q000201:enzymology / Q000378:metabolism*; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism*; D014886:Weaning
D000975:Antioxidants; D017392:Thiobarbituric Acid Reactive Substances; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione