The role of the effective concentration in interpreting hemolysis data.
Problems inherent in traditional methods of determining the hemolytic activity of parenteral compounds are discussed. Data taken from a study which closely models the conditions present for an intravenous injection are re-examined. An equation is given which combines several variables into a single parameter, the effective concentration. A strong relationship is found between the effective concentration of the compound of interest and the hemolysis produced.
Ward
G H
GH
Department of Pharmaceutical Sciences, College of Pharmacy, University of Arizona, Tucson.
Yalkowsky
S H
SH
D004305:Dose-Response Relationship, Drug; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D019946:Propylene Glycol; D011409:Propylene Glycols / Q000494:pharmacology; D012996:Solutions
D011409:Propylene Glycols; D012996:Solutions; D019946:Propylene Glycol