Autosomal inheritance of "senile" retinitis pigmentosa. A report of a family with consanguinity.
We describe two sisters affected with retinitis pigmentosa of late onset. Night blindness and progressive visual field loss occurred after 50 years of age in both cases. The parents of affected individuals were first cousins and there was no known history of other similar cases in previous generations. Autosomal recessive inheritance is suggested for such senile retinitis pigmentosa.
Bonneau
D
D
Service de Pédiatrie, Centre Hospitalier Universitaire, Poitiers, France.
Kaplan
J
J
Girard
G
G
Dufier
J L
JL
D000368:Aged; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D003241:Consanguinity; D005260:Female; D005808:Genes, Recessive; D006801:Humans; D008875:Middle Aged; D010375:Pedigree; D012174:Retinitis Pigmentosa / Q000235:genetics*