Eccrine gland involvement in Krabbe's disease.
Lysosomal storage inclusions were observed in skin eccrine gland secretory and myoepithelial cells in three cases of Krabbe's disease. In addition to storage there were numerous degenerative changes, occasionally resulting in cell necrosis. These findings suggest a generalized nature of the storage process in this lysosomal enzymopathy and point to high galactocerebroside turnover in eccrine gland epithelium. This knowledge may be of value in the biopsy diagnosis of Krabbe's disease.
Elleder
M
M
First Hlava's Institute of Pathology, First Medical Faculty, Charles University Studnickova, Prague, Czechoslovakia.
D002648:Child; D004439:Eccrine Glands / Q000473:pathology*; D006801:Humans; D007223:Infant; D007965:Leukodystrophy, Globoid Cell / Q000473:pathology*; D008297:Male