Effect of the short follicular phase on subsequent conception.
The present study was designed to evaluate whether there is a lower pregnancy rate in women with short follicular phases, as defined by attaining the peak estradiol level before day 11 of the cycle. Thirty-two early ovulators with mature follicles were matched with 32 women being treated for similar infertility problems, who ovulated between days 12-20. Pregnancies were achieved by 9 (28.1%) of the early ovulators compared to 19 (59.4%) of the controls. The mean number of cycles required to achieve a pregnancy was 8.6 in the early ovulators compared to 6.4 in the controls. Using the clinical life table method, the 12-month pregnancy rate was estimated to be 31.4% for early ovulators as compared to 66.3% for controls. Whether lengthening the follicular phase by drug treatment will improve pregnancy rates remains to be seen.
Check
J H
JH
Department of Obstetrics and Gynecology, Cooper Hospital/University Medical Center, Robert Wood Johnson Medical School, Camden, N.J.
Adelson
H
H
Lurie
D
D
Jamison
T
T
D000328:Adult; D004958:Estradiol / Q000097:blood; D005260:Female; D005306:Fertilization / Q000502:physiology*; D005498:Follicular Phase; D006801:Humans; D007247:Infertility, Female / Q000503:physiopathology* / Q000628:therapy; D015993:Life Tables; D006080:Ovarian Follicle / Q000502:physiology*; D010060:Ovulation / Q000502:physiology; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D011374:Progesterone / Q000627:therapeutic use
D011374:Progesterone; D004958:Estradiol