[Amino acid metabolism in surgical stress].
Amino acid metabolism under surgical stress, injury or infection was reviewed from the literature. The glucose-alanine cycle in coupling with branched chain amino acids (BCAA) metabolism plays a central role for gluconeogenesis, in such a catabolic state. Glutamine is as important as alanine for sparing glucose and furthermore for intestinal repair. Changes in plasma amino acid concentration and clearance following hepatectomy are described, and effects of BCAA solution are evaluated. It was suggested that BCAA improved the Fischer ratio by increasing, not only plasma BCAA level, but also AAA clearance.
Shimazu
M
M
Department of Surgery, Fujita Health University School of Medicine.
Aoki
H
H
D000409:Alanine / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism*; D000597:Amino Acids, Branched-Chain / Q000008:administration & dosage / Q000378:metabolism; D004734:Energy Metabolism; D005943:Gluconeogenesis; D005947:Glucose / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism; D006498:Hepatectomy; D006801:Humans; D013312:Stress, Physiological / Q000378:metabolism / Q000628:therapy
D000596:Amino Acids; D000597:Amino Acids, Branched-Chain; D005973:Glutamine; D005947:Glucose; D000409:Alanine