title: Protective effects of an oral microencapsulated Mycoplasma hyopneumoniae vaccine against experimental infection in pigs.
abstract: Oral microencapsulated Mycoplasma hyopneumoniae vaccines were tested for their ability to prevent mycoplasmal pneumonia in pigs. Eighteen four-week-old specific pathogen free pigs were divided into six groups of three. Each pig of groups 1 to 4 was inoculated intramuscularly with formalin-inactivated M hyopneumoniae in adjuvant and boosted orally 14 days later with four different microencapsulated vaccine microspheres. Group 5 was used as a positive control. All 15 pigs of groups 1 to 5 were challenged at 28 days after the first vaccination by an intratracheal inoculation of pneumonic lung suspension. The three pigs of group 6 were used as a negative control. All four vaccinated groups showed some protection when challenged, but the protection was more solid in pigs boosted with vaccine D (group 4) which contained less porcine serum in the microsphere. The study indicates that oral vaccination with M hyopneumoniae could play a role in prevention and eradication of mycoplasmal pneumonia in the pig.
authors.affiliation: Department of Pathology, Pig Research Institute, Chu-Nan, Miaoli, Taiwan.
authors.forename: C N
authors.initials: CN
authors.lastname: Weng
authors.forename: Y L
authors.initials: YL
authors.lastname: Tzan
authors.forename: S D
authors.initials: SD
authors.lastname: Liu
authors.forename: S Y
authors.initials: SY
authors.lastname: Lin
authors.forename: C J
authors.initials: CJ
authors.lastname: Lee
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000276:immunology; D002482:Cellulose / Q000031:analogs & derivatives; D004339:Drug Compounding; D045729:Pneumonia of Swine, Mycoplasmal / Q000517:prevention & control / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000517:prevention & control*
chemical_list: D001428:Bacterial Vaccines; D002482:Cellulose; C011708:cellulose acetate phthalate