Mutagenicity and antimutagenicity of hispidulin and hortensin, the flavonoids from Millingtonia hortensis L.
Studies of the mutagenicity and antimutagenicity of hispidulin and hortensin, the flavonoids from Millingtonia hortensis L. (Bignoniaceae), were performed using the liquid preincubation method of the Salmonella/microsome test. At the highest dose tested, 100 micrograms/plate, both compounds showed no mutagenicity and no cytotoxicity toward S. typhimurium strains TA98 and TA100 either in the presence or absence of S9 mix. However, these substances were antimutagens toward 2-aminoanthracene, aflatoxin B1 (in TA98), and dimethylnitrosamine (in TA100); but neither substance inhibited the direct mutagenic activity of 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide nor that of sodium azide in strains TA98 and TA100, respectively.
Chulasiri
M
M
Department of Microbiology, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
Bunyapraphatsara
N
N
Moongkarndi
P
P
D016604:Aflatoxin B1 / Q000037:antagonists & inhibitors; D000873:Anthracenes; D016587:Antimutagenic Agents / Q000737:chemistry / Q000494:pharmacology*; D001386:Azides; D002470:Cell Survival / Q000187:drug effects; D004128:Dimethylnitrosamine / Q000037:antagonists & inhibitors; D047309:Flavones; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D008862:Microsomes, Liver / Q000201:enzymology; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D019810:Sodium Azide; D013489:Suppression, Genetic; D013876:Thiophenes
D000873:Anthracenes; D016587:Antimutagenic Agents; D001386:Azides; D047309:Flavones; D005419:Flavonoids; D009153:Mutagens; D013876:Thiophenes; C078130:hortensin flavonoid; C028976:3-(5-nitro-2-thienyl)-2-(2-furyl)acrylamide; C006593:2-anthramine; D019810:Sodium Azide; D016604:Aflatoxin B1; D004128:Dimethylnitrosamine; C055957:hispidulin