Cellular reaction following cataract surgery with implantation of the heparin-surface-modified intraocular lens in rabbits with experimental uveitis.
The inflammatory response after cataract surgery and intraocular lens (IOL) implantation was studied in rabbits with endotoxin-induced uveitis. On days 1, 3, 7, 14, and 30 postoperatively the rabbits were sacrificed and the number of white blood cells in the aqueous humor and cellular deposits on the IOLs were estimated. On days 14 and 30 the rabbits also had slitlamp examination to study the clinical outcome of the surgery. At day 1 after lens extraction and IOL implantation, the number of white blood cells in the aqueous humor was significantly lower (P < .05) in eyes with heparin-surface-modified (HSM) IOLs (795.2 +/- 262.9; mean +/- SEM) than in eyes with poly(methyl methacrylate) (PMMA) lenses (1386.5 +/- 247.9). No differences were seen at day 3, 7, 14, or 30 postoperatively. The choice of IOL material had no effect on the amount of cell deposits on the IOL surface or on clinical parameters such as anterior synechias, posterior synechias, fibrosis, and posterior capsular opacification. There was a trend toward a greater number of cellular deposits on the PMMA lenses, but this was not statistically significant. This study provides further evidence of improved biocompatibility of the HSM PMMA lens, as demonstrated by a decreased acute inflammatory response.
Lundgren
B
B
Kabi Pharmacia Ophthalmics, Department of Biology, Uppsala, Sweden.
Holst
A
A
Tärnholm
A
A
Rolfsen
W
W
D000208:Acute Disease; D000818:Animals; D001082:Aqueous Humor / Q000276:immunology; D001672:Biocompatible Materials; D002387:Cataract Extraction; D004195:Disease Models, Animal; D004731:Endotoxins; D004926:Escherichia coli; D006493:Heparin; D007111:Immunity, Cellular; D007910:Lenses, Intraocular; D007962:Leukocytes / Q000276:immunology*; D008070:Lipopolysaccharides; D011817:Rabbits; D014605:Uveitis / Q000209:etiology / Q000276:immunology* / Q000601:surgery
D001672:Biocompatible Materials; D004731:Endotoxins; D008070:Lipopolysaccharides; C044101:endotoxin, Escherichia coli; D006493:Heparin