The effects of deprenyl on methamphetamine-induced dopamine depletions.
The effects of deprenyl on methamphetamine-induced dopamine depletions were studied in mice. Four SC injections of 12.5 mg/kg of methamphetamine at two-hour intervals caused substantial (72-82%) and long-lasting depletions of striatal dopamine. Pretreatment with either 25 or 40 mg/kg of deprenyl did not significantly alter the magnitude of this depletion. These results indicate that, unlike what is observed following MPTP, there is no protection afforded dopaminergic cells by deprenyl pretreatment in the methamphetamine model of parkinsonism.
Johnson
S K
SK
Department of Psychology, Rutgers University, New Brunswick, NJ.
Medina
D
D
Wagner
G C
GC
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D051379:Mice; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000378:metabolism; D012642:Selegiline / Q000494:pharmacology*; D012701:Serotonin / Q000378:metabolism
D012642:Selegiline; D012701:Serotonin; D008694:Methamphetamine; D004298:Dopamine