[The effect of ketoconazole on the cholesterol content of the blood serum lipoproteins and bile in experimental hypercholesterolemia].
Inclusion of ketonazole (in a daily dose of 400 mg/kg for 8 days) into the diet of intact and cholesterol-fed (5% dietary cholesterol) rats produced a respective 20- and 30-percent lowering of cholesterol content in blood serum. In all the animals, the hypocholesterolemic effect of ketoconazole was realized via a decrease of the concentration of very low and low density lipoproteins. Ketoconazole also gave rise to a reduction of the concentration of cholesterol and bile acids in bile of the intact rats and of cholesterol in bile of the cholesterol-fed animals.
Dushkin
M I
MI
Ivanova
M V
MV
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001646:Bile / Q000737:chemistry / Q000187:drug effects*; D002784:Cholesterol / Q000097:blood*; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D004353:Drug Evaluation, Preclinical; D006937:Hypercholesterolemia / Q000188:drug therapy* / Q000378:metabolism; D007654:Ketoconazole / Q000494:pharmacology* / Q000627:therapeutic use; D008074:Lipoproteins / Q000097:blood / Q000187:drug effects*; D008297:Male; D051381:Rats
D000924:Anticholesteremic Agents; D002791:Cholesterol, Dietary; D008074:Lipoproteins; D002784:Cholesterol; D007654:Ketoconazole
Vliianie ketokonazola na soderzhanie kholesterina v lipoproteidakh syvorotki krovi i v zhelchi pri éksperimental'noĭ giperkholesteronemii.