title: Immunization of rabbits against nymphs of Amblyomma hebraeum and A. marmoreum (Acari: Ixodidae).
abstract: Himalayan rabbits immunized with homogenates prepared from nymphs of Amblyomma hebraeum Koch and A. marmoreum Koch ticks developed humoral and probably also cell-mediated immunity to their respective homogenates. Beta and gamma globulin levels and numbers of eosinophils and neutrophils increased significantly in inoculated rabbits. The recipient animals developed resistance to homospecific nymphal infestations. Cross resistance between the two species was not evaluated. Nymphs of both species that fed on inoculated rabbits demonstrated slightly shorter feeding periods, and their mean weights were significantly lower than nymphs that fed on Quil 'A' adjuvant-inoculated rabbits or on naive rabbits. Significantly higher proportions of nymphs from immunized animals failed to moult when compared with nymphs that fed on the two control groups. These parameters indicate that the inoculated rabbits had acquired protective immunity against nymphs of both ticks.
authors.affiliation: Department of Biology, Medical University of Southern Africa, Medunsa.
authors.forename: S D
authors.initials: SD
authors.lastname: Tembo
authors.forename: Y
authors.initials: Y
authors.lastname: Rechav
mesh_terms: D000818:Animals; D000917:Antibody Formation; D005260:Female; D007114:Immunization; D008297:Male; D009758:Nymph; D011817:Rabbits / Q000276:immunology* / Q000469:parasitology; D013984:Tick Infestations / Q000517:prevention & control* / Q000662:veterinary*; D013987:Ticks / Q000276:immunology*