The action of interleukin 6 on lymphoid populations.
We have analysed the role of IL-6 in activation of human lymphocytes isolated from peripheral blood. We found little effect of IL-6 on proliferation of T cells. IL-6 did stimulate production of IgM by B cells. However, it did not behave as a terminal differentiation factor and was required only during the first two days of the culture. Under most conventional stimulation conditions T cells themselves produce little or no IL-6. High IL-6 production could be induced by stimulating the cells with a combination of phorbol-12-myristate 13-acetate (PMA) and anti-CD28 antibodies.
Aarden
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LA
Central Laboratory of the Netherlands Red Cross Bloodtransfusion Service, Amsterdam.
van Kooten
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C
D001402:B-Lymphocytes / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis / Q000502:physiology*; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000378:metabolism
D015850:Interleukin-6