Behavioral and electroencephalographic effects of a serotonin receptor agonist (5-methoxy-N,N-dimethyltryptamine) in a feline model of photosensitive epilepsy.
The effects of a serotonin (5-HT) receptor agonist, 5-methoxy-N,N-dimethyltryptamine (5-MeODMT), on epileptic photosensitivity were studied in the lateral geniculate-kindled cat. 5-MeODMT at 4 mg/kg significantly suppressed photically induced myoclonus, but not paroxysmal EEG activity, at 0.5-1 h after injection. This antiepileptic effect was seen in association with the appearance of behavioral signs similar to those seen in the 5-HT syndrome. The present data provide further evidence that 5-HT plays an important role in photosensitive epilepsy, and suggest that the inhibitory effect of 5-MeODMT on photosensitivity results from its agonist action at 5-HT1 receptors.
Wada
Y
Y
Department of Neuropsychiatry, Kanazawa University School of Medicine, Japan.
Hasegawa
H
H
Nakamura
M
M
Yamaguchi
N
N
D000818:Animals; D002415:Cats; D004195:Disease Models, Animal; D004569:Electroencephalography / Q000187:drug effects*; D004827:Epilepsy / Q000503:physiopathology* / Q000517:prevention & control; D005829:Geniculate Bodies / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology; D007696:Kindling, Neurologic; D008732:Methoxydimethyltryptamines / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D010775:Photic Stimulation; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D012640:Seizures / Q000503:physiopathology* / Q000517:prevention & control; D013239:Stereotyped Behavior / Q000187:drug effects*; D013997:Time Factors
D008732:Methoxydimethyltryptamines; D011985:Receptors, Serotonin