Follow up study of renal tubular dysfunction and mortality in residents of an area polluted with cadmium.
A retrospective cohort study was conducted to investigate the association between cadmium induced renal tubular dysfunction and mortality. A total of 230 subjects aged 40 or older and living in a cadmium polluted area in Kosaka Town, Akita Prefecture, Japan, were studied at least once between 1975 and 1977 and again in 1990. Urinary beta 2-microglobulin and total amino nitrogen concentrations were significantly related to mortality from all causes in women. The finding supports the idea that cadmium induced kidney damage is a factor associated with mortality in a general population exposed to environmental cadmium.
Iwata
K
K
Department of Preventive Medicine and Health Promotion, Nagasaki University School of Medicine, Japan.
Saito
H
H
Moriyama
M
M
Nakano
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002105:Cadmium Poisoning / Q000401:mortality* / Q000503:physiopathology; D015331:Cohort Studies; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007674:Kidney Diseases / Q000401:mortality* / Q000503:physiopathology; D007684:Kidney Tubules / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies