[The role of endogenous K+ in realizing the protective action of M-cholinolytics in chlorophos poisoning].
The protective effect of M-cholinolytics during the poisoning of mice with chlorophos or exogenous acetylcholine is characterized by certain specific features. An attempt to reproduce the cholinolytic effect during poisoning by organophosphorus compounds was successful in case where the intoxication by a direct cholinomimetic was carried out in the presence of KCl solution or where the animals' poisoning was preceded by administration of voltage-dependent K+ channel blockers. The conclusion is made that the increased concentration of extracellular K+ occurring as the result of poisoning with organophosphorus compounds may play a role in the mechanism of the protective action of M-cholinolytics in chlorophos poisoning.
Kosmachev
A B
AB
Kosmacheva
I M
IM
Fil'ko
O A
OA
Luleshov
V I
VI
D000109:Acetylcholine / Q000506:poisoning; D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D051379:Mice; D010276:Parasympatholytics / Q000627:therapeutic use*; D011041:Poisoning / Q000188:drug therapy; D011188:Potassium / Q000502:physiology*; D014236:Trichlorfon / Q000506:poisoning*
D000931:Antidotes; D002121:Calcium Channel Blockers; D010276:Parasympatholytics; D014236:Trichlorfon; D000109:Acetylcholine; D011188:Potassium
Rol' éndogennogo K+ v osushchestvlenii zashchitnogo deĭstviia M-kholinolitikov pri otravlenii khlorofosom.