[The mechanism of action of dimephosphon].
It has been established in experiments on rats that the 7-day administration of dimephosphon per os increases blood levels of total mercapto groups and glutathione, changing the correlation of its forms in favour of the oxidized ones. This course of dimephosphon administration reduces blood concentration of lipid peroxidation products. The significance of these mechanisms in realization of the pharmacological effects of dimephosphon is under discussion.
Ziganshina
L E
LE
Studentsova
I A
IA
Ziganshin
A U
AU
Valeeva
I Kh
IKh
D000818:Animals; D000863:Antacids / Q000494:pharmacology*; D005978:Glutathione / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009943:Organophosphorus Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D013438:Sulfhydryl Compounds / Q000097:blood; D013997:Time Factors
D000863:Antacids; D008054:Lipid Peroxides; D009943:Organophosphorus Compounds; D013438:Sulfhydryl Compounds; C049638:dimephosphon; D008315:Malondialdehyde; D005978:Glutathione
Mekhanizm deĭstviia dimefosfona.