Mass spectrometric identification of urinary and plasma metabolites of 2-(6'-carboxyhexyl)-3-n-hexylcyclohexylamine, a new antiaggregating agent.
The compound IBI-P-05006, 2-(6'-carboxyhexyl)-3-n-hexylcyclohexylamine, is an antiaggregating agent under development. IBI-P-05006 is an in vitro inhibitor of platelet aggregation. The biotransformation of this compound has been studied in the dog and rat. We present here a study on the metabolites of IBI-P-05006 found in dog and rat urine, and in dog plasma. Analyses were done by gas chromatography-mass spectrometry. In dog urine 15 metabolites were identified. Some of them were also found in dog plasma and in rat urine. The unmetabolized drug was found only in plasma. 10 different hydroxylated metabolites were characterized. The hydroxyl groups were introduced in the hexyl chain in positions omega-4, omega-3, omega-2, omega-1 and omega.
Benfenati
E
E
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Fanelli
R
R
Bosone
E
E
Caponi
R
R
Farina
P
P
D000818:Animals; D003514:Cyclohexylamines / Q000378:metabolism*; D004285:Dogs; D005260:Female; D013058:Mass Spectrometry; D010975:Platelet Aggregation Inhibitors / Q000378:metabolism*; D051381:Rats
D003514:Cyclohexylamines; D010975:Platelet Aggregation Inhibitors; C078016:2-(6'-carboxyhexyl)-3-n-hexylcyclohexylamine