In vitro activity of sulphimidazole alone and in association with trimethoprim against enteric pathogens.
Sulphimidazole is a new sulphonamide belonging to the class of intestinal sulphonamides and characterized by the fact that it is active even in vitro. It has the heterocyclic ring of 5-nitroimidazoles on amidic nitrogen. Its antibacterial activity is similar to that of the classical sulphonamides but differs in that it also combats certain anaerobic bacteria such as Clostridium botulinum. This effect is completely absent in the case of sulphadiazine and sulphamethoxazole. Also, since p-amino-benzene-sulphonamide is present in the molecule, the drug acts in synergism with trimethoprim against certain aerobic or facultative strains of enteric pathogens.
Castelli
M
M
Institute of Pharmacology, University of Modena, Italy.
Baggio
G
G
Ruberto
A I
AI
Rossi
T
T
Provvisionato
A
A
Malagoli
M
M
Bossa
R
R
Galatulas
I
I
D001419:Bacteria / Q000187:drug effects*; D001421:Bacteria, Anaerobic / Q000187:drug effects; D003013:Clostridium / Q000187:drug effects; D003470:Culture Media; D004357:Drug Synergism; D004755:Enterobacteriaceae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009593:Nitroimidazoles / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013449:Sulfonamides / Q000494:pharmacology*; D014295:Trimethoprim / Q000494:pharmacology*
D003470:Culture Media; D009593:Nitroimidazoles; D013449:Sulfonamides; C061005:1-methyl-2-((4-aminophenyl)sulfonyl)amino-5-nitroimidazole; D014295:Trimethoprim