[HIV infection in infants under 15 months of age. Value of the p-24 antigen as a prognostic marker].
We have studied 65 children, born to HIV seropositive mothers, during the first quarter of life and afterwards every three-months. During this time, ten of the children (13%) became infected with the virus. The study of p24 antigen during the first 15 months of life showed an inverse relationship between the permanent presence of P24 antigen in the serum and the absence of anti-p24 antibodies. Since both markers were related to a bad prognosis, it is useful to carry-out the routine study of p24 antigen and its level in serum. Of the infections detected, 3 cases were early onset and the other 7 cases later onset. The three children from the first group died between 4 and 8 months of life, while the second group had a much more stable clinical situation. The children with early onset infections had T4 lymphocytes lower than 500 cell/mm3, detectable p24 antigen, and a fatal progression of the disease.
Pérez Alvarez
L
L
Centro Nacional de Biología Celular y Retrovirus, Instituto de Salud Carlos III, Majadahonda, Madrid.
Hernández Sampelayo
T
T
Gurbindo Gutiérrez
D
D
Varela Fernández
J M
JM
Contreras Carrasco
G
G
García Saiz
A
A
Najera Morrondo
R
R
D000163:Acquired Immunodeficiency Syndrome / Q000635:transmission*; D000367:Age Factors; D015415:Biomarkers; D005260:Female; D015488:HIV Antigens / Q000276:immunology*; D015658:HIV Infections / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011379:Prognosis
D015415:Biomarkers; D015488:HIV Antigens
Infección por el virus de la inmunodeficiencia humana en niños menores de 15 meses. Valoración del antígeno p-24 como marcador pronóstico.