A non-isotopic in situ hybridisation study of the chromosomal origin of 15 supernumerary marker chromosomes in man.
Fifteen patients presenting with mosaic or non-mosaic karyotypes containing a distamycin-DAPI negative de novo or familial supernumerary marker chromosome were studied with non-isotopic in situ hybridisation using a library of alphoid centromere specific and satellite II/III probes. The in situ hybridisation studies showed that seven markers were derived from satellited autosomes (three chromosome 13/21, two chromosome 14, two chromosome 22), six from non-satellited autosomes (two chromosome 4, one chromosome 12, one chromosome 16, two chromosome 19), and one from the Y chromosome. One non-mosaic marker was negative for all the alphoid and satellite II/III probes used.
Crolla
J A
JA
Wessex Regional Genetics Laboratory, Salisbury District Hospital, Odstock, Wiltshire.
Dennis
N R
NR
Jacobs
P A
PA
D000015:Abnormalities, Multiple / Q000235:genetics; D000328:Adult; D000649:Amniocentesis; D002675:Child, Preschool; D015193:Chorionic Villi Sampling; D002869:Chromosome Aberrations; D015342:DNA Probes / Q000235:genetics; D005260:Female; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D017403:In Situ Hybridization; D007231:Infant, Newborn; D008607:Intellectual Disability / Q000235:genetics; D008297:Male; D010641:Phenotype; D011247:Pregnancy
D015342:DNA Probes; D005819:Genetic Markers