title: Role of topical lignocaine during carotid endarterectomy.
abstract: Forty carotid endarterectomies were undertaken in 34 patients. Operations were prospectively randomized to periarterial application of either 1 per cent lignocaine (n = 19) or normal saline (n = 21), and detailed measurements taken of intraoperative pulse rate and blood pressure. Patients receiving lignocaine demonstrated a lower pulse rate, and lower systolic and mean blood pressures than those receiving placebo, with significance in relation to clamp application and shunt removal (P < 0.05). It was particularly noticeable that patients receiving lignocaine demonstrated less intraoperative variation in pulse rate and blood pressure. Topical lignocaine stabilizes pulse rate and blood pressure during carotid endarterectomy.
authors.affiliation: Department of Vascular Surgery, Manchester Royal Infirmary, UK.
authors.forename: M
authors.initials: M
authors.lastname: Welch
authors.forename: W F
authors.initials: WF
authors.lastname: Tait
authors.forename: D
authors.initials: D
authors.lastname: Durrans
authors.forename: H M
authors.initials: HM
authors.lastname: Carr
authors.forename: P W
authors.initials: PW
authors.lastname: Jackson
authors.forename: M G
authors.initials: MG
authors.lastname: Walker
mesh_terms: D000287:Administration, Topical; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D016894:Endarterectomy, Carotid; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007430:Intraoperative Care; D008012:Lidocaine / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D008012:Lidocaine