Interferon-gamma.
During the past year, the most striking progress in our understanding of interferon-gamma has been made in the elucidation of the three-dimensional structure of the molecule and in the analysis of the molecular structure and the functional domains of the interferon-gamma receptor. A greater insight into the molecular mechanisms of gene activation by interferon-gamma has been gained, and the immunoregulatory role of interferon-gamma has been better defined in studies dealing with its effects on B-cell function and with its production by the various T-cell subsets. Finally, the effects of interferon-gamma on intracellular parasites is an important aspect of interferon-gamma activity that is giving rise to several clinical trials.
De Maeyer
E
E
CNRS, Institut Curie, Orsay, France.
De Maeyer-Guignard
J
J
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D001483:Base Sequence; D016384:Consensus Sequence; D016207:Cytokines / Q000502:physiology; D006801:Humans; D007371:Interferon-gamma / Q000737:chemistry / Q000502:physiology*; D008969:Molecular Sequence Data; D017471:Receptors, Interferon / Q000737:chemistry; D013329:Structure-Activity Relationship; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D016207:Cytokines; D017471:Receptors, Interferon; D007371:Interferon-gamma