title: In vitro activities of streptomycin and 11 oral antimicrobial agents against clinical isolates of Klebsiella rhinoscleromatis.
abstract: We tested in vitro the activities of streptomycin and tetracycline--antibiotics that have long been used to treat rhinoscleroma--as well as several newer oral agents by using 23 isolates of the causative organism Klebsiella rhinoscleromatis. All isolates were inhibited by clinically achievable concentrations of trimethoprim-sulfamethoxazole, amoxicillin-clavulanate, chloramphenicol, ciprofloxacin, cephalexin, cefuroxime, and cefpodoxime.
authors.affiliation: Section of Infectious Diseases, Medical Service, Department of Veterans Affairs Medical Center, Houston, Texas.
authors.forename: B A
authors.initials: BA
authors.lastname: Perkins
authors.forename: R J
authors.initials: RJ
authors.lastname: Hamill
authors.forename: D M
authors.initials: DM
authors.lastname: Musher
authors.forename: C
authors.initials: C
authors.lastname: O'Hara
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004359:Drug Therapy, Combination / Q000494:pharmacology; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D012226:Rhinoscleroma / Q000382:microbiology; D013307:Streptomycin / Q000494:pharmacology*; D013754:Tetracyclines / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D013754:Tetracyclines; D013307:Streptomycin