A low molecular weight calf pineal peptide with an inhibiting effect on the growth of L1210 and HL60 cells.
The peptide isolated by us from calf pineal gland causes a reduction of RNA synthesis in vitro in L1210 and HL60 tumoral cells. This peptide also causes inhibition of cell proliferation; the cell viability is not modified. The effects are dose-dependent and reversible.
Petrelli
C
C
Department of Molecular, Cellular and Animal Biology, University of Camerino, Italy.
Moretti
P
P
Petrelli
F
F
Bramucci
M
M
D000818:Animals; D002417:Cattle; D002455:Cell Division / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007939:Leukemia L1210; D015473:Leukemia, Promyelocytic, Acute; D051379:Mice; D009479:Neuropeptides / Q000302:isolation & purification / Q000494:pharmacology*; D010870:Pineal Gland / Q000737:chemistry*; D012334:RNA, Neoplasm / Q000096:biosynthesis*; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D009479:Neuropeptides; D012334:RNA, Neoplasm