title: Effect of physical exercise in hypobaric conditions on atrial natriuretic peptide secretion.
abstract: To evaluate the role of atrial natriuretic peptide (ANP) in exercise-related cardiovascular and hormonal adjustments in hypobaric conditions, 14 young athletes performed a maximal ergometer test in a hypobaric chamber adjusted to simulate the altitudes of sea level and 3,000 m. Plasma immunoreactive ANP levels rose from 5.89 to 35.1 pmol/l at sea level and rose significantly less (P less than 0.05), from 5.36 to 22.3 pmol/l, at simulated 3,000 m. Plasma immunoreactive amino-terminal peptide of proANP (NT-proANP) levels increased to the same extent at sea level and at simulated 3,000 m (from 240 to 481 pmol/l and from 257 to 539 pmol/l, respectively). Plasma immunoreactive aldosterone increased significantly less at simulated 3,000 m (P less than 0.05), but the changes in plasma renin were similar in both conditions. Plasma immunoreactive endothelin-1 and serum erythropoietin levels remained unchanged. In conclusion, we found a blunted ANP response to maximal exercise of ANP in acute hypobaric exposure compared with that in normobaric conditions, but no significant difference in the NT-proANP responses between the two conditions. The divergence may be due to stimulation of the elimination mechanism of ANP.
authors.affiliation: Department of Physiology, University of Oulu, Finland.
authors.forename: O
authors.initials: O
authors.lastname: Vuolteenaho
authors.forename: P
authors.initials: P
authors.lastname: Koistinen
authors.forename: V
authors.initials: V
authors.lastname: Martikkala
authors.forename: T
authors.initials: T
authors.lastname: Takala
authors.forename: J
authors.initials: J
authors.lastname: Leppäluoto
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood; D001274:Atmospheric Pressure; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000378:metabolism*; D001794:Blood Pressure; D001810:Blood Volume; D005260:Female; D006339:Heart Rate; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008297:Male; D010100:Oxygen / Q000097:blood; D005082:Physical Exertion; D012083:Renin / Q000097:blood
chemical_list: D007773:Lactates; D019344:Lactic Acid; D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012083:Renin; D010100:Oxygen; D006854:Hydrocortisone