Effect of dietary butylated hydroxytoluene on nuclear envelope cytochrome P-450 during the initiation and promotion stages of hepatocarcinogenesis.
The anticarcinogenic effect of the dietary antioxidant butylated hydroxytoluene (BHT) correlates with a preservation of nuclear envelope (NE) cytochrome P-450 in rats undergoing chemically induced hepatocarcinogenesis. This effect of BHT on NE cytochrome P-450 was observed during both the initiation and the promotion stages of hepatocarcinogenesis. Complex interactions between the two different mechanisms of action of BHT (i.e., enzyme induction and antioxidant activity) may account for some of the differences between the patterns of response to BHT observed during initiation and promotion.
Carubelli
R
R
Molecular Toxicology Research Program, Oklahoma Medical Research Foundation, Oklahoma City.
Graham
S A
SA
McCay
P B
PB
D000818:Animals; D002084:Butylated Hydroxytoluene / Q000008:administration & dosage / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis*; D004032:Diet; D008113:Liver Neoplasms / Q000517:prevention & control*; D008297:Male; D009685:Nuclear Envelope / Q000187:drug effects* / Q000201:enzymology; D051381:Rats; D011916:Rats, Inbred F344
D002084:Butylated Hydroxytoluene; D003577:Cytochrome P-450 Enzyme System