Effect of drug therapy on the relapse of peptic ulcers. 2nd communication: the effect of maintenance therapy.
One-year maintenance therapy with pirenzepine (Gastrozepin, CAS 28797-61-7) (75 mg/d) or placebo was performed in a double-blind fashion in 251 patients to investigate the relapse by means of endoscopic examinations repeated every 3 months. Enrolled were the patients who had been cured within 3 months by acute therapy with either pirenzepine or cimetidine randomly given by the envelope method. When the results were analyzed by Cutler-Ederer's life table method to monitor manifestation of relapse, the maintenance therapy with pirenzepine did not show any significant difference from placebo in all the patients enrolled. However, stratified analysis according to various combinations of background factors revealed that there was significant difference in 1-year cumulative non-relapse rates between the pirenzepine maintenance therapy group and the placebo group, suggesting prophylactic effect of the maintenance therapy with pirenzepine on relapse. An increase of daily dose more than 75 mg in maintenance therapy may be expected to display the prophylactic effect of pirenzepine on ulcer relapse in a definite manner.
Ishimori
A
A
Department of Clinical and Laboratory Medicine, Tohoku University School of Medicine, Sendai, Japan.
Kawamura
T
T
Koizumi
F
F
D002927:Cimetidine / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D010437:Peptic Ulcer / Q000473:pathology / Q000517:prevention & control*; D010890:Pirenzepine / Q000009:adverse effects / Q000627:therapeutic use*; D012008:Recurrence
D010890:Pirenzepine; D002927:Cimetidine