title: Heterogeneity of Tau proteins during mouse brain development and differentiation of cultured neurons.
abstract: Tau microtubule-associated proteins constitute a group of developmentally regulated neuronal proteins. Using the high-resolution two-dimensional polyacrylamide gel electrophoresis system, we have resolved more than 60 distinct Tau isoforms in the adult mouse brain. Tau protein heterogeneity increases drastically during the second week of brain development. In neuronal primary cell cultures, some of these developmental changes can be observed. The increase of Tau heterogeneity in culture is more limited and reaches a plateau after a period corresponding to the second week of development. Most, if not all, of the vast Tau heterogeneity can be attributed to intensive post-translational phosphorylation, which may affect the structure of the proteins.
authors.affiliation: Laboratoire de Biochimie Cellulaire, Collège de France, Paris, France.
authors.forename: J C
authors.initials: JC
authors.lastname: Larcher
authors.forename: D
authors.initials: D
authors.lastname: Boucher
authors.forename: I
authors.initials: I
authors.lastname: Ginzburg
authors.forename: F
authors.initials: F
authors.lastname: Gros
authors.forename: P
authors.initials: P
authors.lastname: Denoulet
mesh_terms: D000818:Animals; D001921:Brain / Q000196:embryology*; D001923:Brain Chemistry; D002478:Cells, Cultured; D007700:Kinetics; D051379:Mice; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D051381:Rats; D017208:Rats, Wistar; D016875:tau Proteins / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D016875:tau Proteins