Carbonic anhydrase inhibitors. V: Pyrylium salts in the synthesis of isozyme-specific inhibitors.
Syntheses and physicochemical properties of 2,4,6-tri-, 2,3,4,6-tetra-, or 2,3,4,5,6-pentasubstituted 1-(2-sulfonamido-1,3,4-thiadiazol-5-yl)pyridinium perchlorates are presented. The new compounds, putative inhibitors of membrane-bound carbonic anhydrase, were tested for inhibitory action on the bovine red cell enzyme.
Supuran
C T
CT
Department of Organic Chemistry, University of Bucharest, Romania.
Manole
G
G
Dinculescu
A
A
Schiketanz
A
A
Gheorghiu
M D
MD
Puscas
I
I
Balaban
A T
AT
D002257:Carbonic Anhydrase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D007527:Isoenzymes; D009682:Magnetic Resonance Spectroscopy; D011726:Pyridinium Compounds / Q000138:chemical synthesis*; D013830:Thiadiazoles / Q000138:chemical synthesis*
D002257:Carbonic Anhydrase Inhibitors; D007527:Isoenzymes; D011726:Pyridinium Compounds; D013830:Thiadiazoles