Thromboxane does not play a significant role in acute, cold-induced vasoconstriction in Raynaud's phenomenon. Studies with combined thromboxane synthase inhibition and thromboxane receptor antagonism.
Gresele
P
P
Istituto di Semeiotica Medica, University of Perugia, Italy.
Volpato
R
R
Migliacci
R
R
Vezza
R
R
Boschetti
E
E
Nenci
G G
GG
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D003080:Cold Temperature; D004311:Double-Blind Method; D005260:Female; D005385:Fingers / Q000098:blood supply; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011928:Raynaud Disease / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D017482:Receptors, Thromboxane / Q000037:antagonists & inhibitors*; D013449:Sulfonamides / Q000494:pharmacology / Q000627:therapeutic use*; D013928:Thromboxane A2 / Q000502:physiology*; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology*
D007093:Imidazoles; D017482:Receptors, Thromboxane; D013449:Sulfonamides; C029166:dazoxiben; D013928:Thromboxane A2; C040624:sulotroban; D013930:Thromboxane-A Synthase