title: Evaluation of S-[11C]citalopram as a radioligand for in vivo labelling of 5-hydroxytryptamine uptake sites.
abstract: The biologically active S-enantiomer of [N-methyl-11C]citalopram was evaluated as a radioligand for in vivo labelling of the 5-hydroxytryptamine uptake site in brain, using ex vivo tissue counting in rats and positron emission tomography in man. In rats, the maximal signal for total versus non-specific binding was approx. 2 at 60-120 min after radioligand injection. Subsequent studies in man failed to identify a specific signal over a 90 min scanning period, due to prolonged retention of non-specific label.
authors.affiliation: MRC Cyclotron Unit, Hammersmith Hospital, London, England.
authors.forename: S P
authors.initials: SP
authors.lastname: Hume
authors.forename: A A
authors.initials: AA
authors.lastname: Lammertsma
authors.forename: C J
authors.initials: CJ
authors.lastname: Bench
authors.forename: V W
authors.initials: VW
authors.lastname: Pike
authors.forename: C
authors.initials: C
authors.lastname: Pascali
authors.forename: J E
authors.initials: JE
authors.lastname: Cremer
authors.forename: R J
authors.initials: RJ
authors.lastname: Dolan
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002250:Carbon Radioisotopes; D015283:Citalopram / Q000378:metabolism*; D008297:Male; D011869:Radioligand Assay; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism*; D013237:Stereoisomerism; D014055:Tomography, Emission-Computed
chemical_list: D002250:Carbon Radioisotopes; D015283:Citalopram; D012701:Serotonin