Efficacy of live-attenuated and whole-inactivated simian immunodeficiency virus vaccines against vaginal challenge with virulent SIV.
The ability of two vaccine preparations (UV-psoralen inactivated SIV administered intramuscularly and live-attenuated SIV inoculated intravaginally) to prevent genital transmission of virulent SIV in rhesus macaques was tested. Two of six whole-inactivated SIV vaccinated macaques, three of five live-attenuated SIV vaccinated macaques, and four of six controls became persistently infected after two separate intravaginal inoculations with a 50% animal infectious dose of virulent SIV. No association was observed between levels of SIV-specific antibodies in serum or vaginal secretions prior to challenge and subsequent infection with virulent SIV.
Marthas
M L
ML
California Regional Primate Research Center, University of California, Davis 95616.
Miller
C J
CJ
Sutjipto
S
S
Higgins
J
J
Torten
J
J
Lohman
B L
BL
Unger
R E
RE
Ramos
R A
RA
Kiyono
H
H
McGhee
J R
JR
D000282:Administration, Intravaginal; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis / Q000097:blood; D004279:DNA, Viral / Q000097:blood; D005260:Female; D007963:Leukocytes, Mononuclear / Q000737:chemistry; D008253:Macaca mulatta; D016133:Polymerase Chain Reaction; D016097:Simian Acquired Immunodeficiency Syndrome / Q000517:prevention & control*; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000276:immunology*; D014611:Vaccination / Q000662:veterinary; D014613:Vaccines, Attenuated / Q000008:administration & dosage; D015164:Vaccines, Inactivated / Q000008:administration & dosage; D014621:Vagina / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage; D014766:Viremia / Q000662:veterinary
D000914:Antibodies, Viral; D004279:DNA, Viral; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated; D014765:Viral Vaccines