title: [Pharmacological studies of sulbactam and its association with semisynthetic beta-lactam antibiotics].
abstract: The acute toxicity, local tolerance and pharmacokinetic properties of sulbactame manufactured by the Iaşi Antibiotic Investigation Centre, alone or in association with ampicillin or amoxicillin were tested. Some tests were made comparatively with the product Unasyn--Pfizer. The obtained data show that this beta-lactamase inhibitor has a low toxicity--DL50 i.p. in mice over 4,000 mg/kg, both alone or associated with the two semisynthetic beta-lactamic antibiotics. The local tolerance is good and the serum levels of the above mentioned associations are above towards the tested bacteria and are similar or very close to those of Unasyn. It is believed that the therapeutical use of the association sulbactame + ampicillin or sulbactame + amoxicillin is very useful in the beta-lactamase producing germs infection.
authors.affiliation: Disciplina de farmacologie, U.M.F. Iaşi.
authors.forename: M
authors.initials: M
authors.lastname: Nechifor
authors.forename: D
authors.initials: D
authors.lastname: Buiuc
authors.forename: E
authors.initials: E
authors.lastname: Diaconu
authors.forename: A
authors.initials: A
authors.lastname: Poiată
authors.forename: E
authors.initials: E
authors.lastname: Teslariu
authors.forename: C
authors.initials: C
authors.lastname: Filip
authors.forename: A
authors.initials: A
authors.lastname: Negru
authors.forename: C
authors.initials: C
authors.lastname: Antonescu
mesh_terms: D000658:Amoxicillin / Q000097:blood / Q000494:pharmacology* / Q000633:toxicity; D000667:Ampicillin / Q000097:blood / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D004361:Drug Tolerance; D007928:Lethal Dose 50; D051379:Mice; D051381:Rats; D013407:Sulbactam / Q000097:blood / Q000494:pharmacology* / Q000633:toxicity; D013997:Time Factors
chemical_list: D000667:Ampicillin; D000658:Amoxicillin; D013407:Sulbactam
vernacular_title: Cercetări farmacologice asupra sulbactamei şi asocierii sale cu unele antibiotice beta-lactamice de semisinteză.