[Measurement of mediators in drug allergies. Preliminary study].
Drug allergy is still a region where diagnosis remains difficult. It relies on clinical history, sometimes skin tests and lymphoblast transformation tests, though only when the antigen is soluble. Provocation tests may, if there is a doubt, prove the involvement of the drug. It may be made objective by the measurement of mediators: ECD and tryptase, thus showing the involvement of eosinophils and mastocytes. Should change in these mediators be associated with a syndromic reaction or is it on its own, a diagnostic factor? A complementary study with a reference group, on a sufficient number of patients has allowed, with the assistance of a statistical analysis, better objectivity from the results.
Sabbah
A
A
Laboratoire d'Immuno-Allergologie, CHU, 49033 Angers.
Caradec
J
J
D000328:Adult; D000799:Angioedema / Q000097:blood / Q000139:chemically induced; D001798:Blood Proteins / Q000032:analysis*; D053818:Chymases; D004342:Drug Hypersensitivity / Q000097:blood* / Q000175:diagnosis; D047091:Eosinophil Granule Proteins; D005260:Female; D006632:Histamine / Q000097:blood*; D006801:Humans; D008297:Male; D010865:Pilot Projects; D012260:Ribonucleases; D012697:Serine Endopeptidases / Q000097:blood*; D053802:Tryptases
D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D006632:Histamine; D012260:Ribonucleases; D012697:Serine Endopeptidases; C083294:chymase 2; D053818:Chymases; D053802:Tryptases
Dosage des médiateurs dans les allergies médicamenteuses. Etude préliminaire.