[Inhibitory effects of the extract of pilose antler on monoamine oxidase in aged mice].
It was demonstrated that the water extract of Pilose Antler (WEPA) showed a higher inhibitory effect on MAO-B activities in the liver and brain tissues of aged mice, but nearly no effect on NAO-A. WEPA could significantly increase the contents of 5-HT, NE and DA in the brain tissues of aged mice. In vitro experiments revealed that the inhibition of WEPA on MAO-B was competitive, but on MAO-A was of mixed-type.
Chen
X
X
Academy of Traditional Chinese Medicine and Materia Medica, Jilin Province, Changchun.
Jia
Y
Y
Wang
B
B
D000375:Aging / Q000187:drug effects; D000818:Animals; D000999:Antlers; D001921:Brain / Q000201:enzymology / Q000378:metabolism; D003670:Deer; D004298:Dopamine / Q000378:metabolism; D005260:Female; D008099:Liver / Q000378:metabolism; D008297:Male; D008419:Materia Medica / Q000494:pharmacology*; D051379:Mice; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism
D008419:Materia Medica; D008996:Monoamine Oxidase Inhibitors; D012701:Serotonin; D008995:Monoamine Oxidase; D004298:Dopamine; D009638:Norepinephrine