title: High pressure liquid chromatographic determination of the new non-steroidal anti-inflammatory agent butibufen.
abstract: High performance liquid chromatography (HPLC) method for the determination and validation of a new non-steroidal anti-inflammatory agent, butibufen (CAS 55837-18-8), microencapsulated butibufen and its pharmaceutical forms--tablets, sachets (microencapsulated butibufen with excipients), microemulsion and cream--is described. Acetonitrile proved to be the best solvent for the extraction of butibufen from its pharmaceutical forms. The results submitted in this paper suggest that the HPLC method for the quantitative determination of butibufen is linear, accurate, precise and sensitive.
authors.affiliation: Research Division, Juste, S.A.Q.F., Madrid, Spain.
authors.forename: L
authors.initials: L
authors.lastname: González Tavares
authors.forename: M J
authors.initials: MJ
authors.lastname: Pérez de la Cruz
authors.forename: P
authors.initials: P
authors.lastname: Sanz Saiz
authors.forename: M A
authors.initials: MA
authors.lastname: Camacho
authors.forename: J L
authors.initials: JL
authors.lastname: Martin
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D002214:Capsules; D002851:Chromatography, High Pressure Liquid; D004655:Emulsions; D010654:Phenylbutyrates / Q000032:analysis*; D011208:Powders; D013607:Tablets
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002214:Capsules; D004655:Emulsions; D010654:Phenylbutyrates; D011208:Powders; D013607:Tablets; C012797:butibufen