title: [Kasabach-Merritt syndrome in children].
abstract: Kasabach-Merritt syndrome is a combination of thrombocytopenia, intravascular coagulation, and a rapid increase in the size of an angioma. Anemia and disseminated intravascular coagulation may develop. This infrequent syndrome is severe and may be life-threatening. Pathophysiologic mechanisms underlying the condition are incompletely understood and, consequently, many different treatments are used, including systemic corticosteroids, compression, embolization, antifibrinolytic agents, platelet aggregation inhibitors, irradiation, and others. From findings in eight personal cases, the authors review clinical and biological features, pathophysiologic hypotheses and therapeutic strategies.
authors.affiliation: Service de Dermatologie, Hôpital Necker Enfants Malades, Paris.
authors.forename: D
authors.initials: D
authors.lastname: Teillac-Hamel
authors.forename: P
authors.initials: P
authors.lastname: Andry
authors.forename: C
authors.initials: C
authors.lastname: Bodemer
authors.forename: P
authors.initials: P
authors.lastname: Hubert
authors.forename: G
authors.initials: G
authors.lastname: Sebag
authors.forename: F
authors.initials: F
authors.lastname: Brunelle
authors.forename: C
authors.initials: C
authors.lastname: Nihoul-Fékété
authors.forename: Y
authors.initials: Y
authors.lastname: de Prost
mesh_terms: D001241:Aspirin / Q000627:therapeutic use; D002675:Child, Preschool; D004211:Disseminated Intravascular Coagulation / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D004621:Embolization, Therapeutic; D006391:Hemangioma / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D007223:Infant; D010372:Pediatrics / Q000379:methods*; D010431:Pentoxifylline / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D011878:Radiotherapy; D013577:Syndrome; D013921:Thrombocytopenia / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D013988:Ticlopidine / Q000627:therapeutic use
chemical_list: D013988:Ticlopidine; D001241:Aspirin; D010431:Pentoxifylline; D011241:Prednisone
vernacular_title: Syndrome de Kasabach-Merritt de l'enfant.