title: [New 5'-phosphonates, modified through the nucleoside sugar residue, as inhibitors of HIV replication].
abstract: A number of nucleoside 5'-phosphonates and nucleoside 5'-methylphosphonates were synthesised, to study their ability to inhibit reproduction of HIV-1. Three compounds, 5'-hydrogen phosphonates of 3'-azido-2',3'-dideoxythymidine (AZT-HP, IVc), 3'-fluoro-2',3'-dideoxythymidine (FLT-HP, IVa) and 2',3'-dideoxyadenosine (ddA-HP, I), exhibit potent anti-HIV-1 activity with selectivity indices similar to or better of those of their parent nucleosides.
authors.forename: A
authors.initials: A
authors.lastname: Kraevskiĭ
authors.forename: N
authors.initials: N
authors.lastname: Tarusova
authors.forename: K Iu
authors.initials: KIu
authors.lastname: Zhu
authors.forename: P
authors.initials: P
authors.lastname: Vidal
authors.forename: T Ch
authors.initials: TCh
authors.lastname: Chu
authors.forename: B
authors.initials: B
authors.lastname: Pol'ski
authors.forename: K Iu
authors.initials: KIu
authors.lastname: Iang
authors.forename: Ia
authors.initials: Ia
authors.lastname: Matulich-Adamich
authors.forename: I
authors.initials: I
authors.lastname: Rozenberg
authors.forename: K A
authors.initials: KA
authors.lastname: Vatanabe
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002241:Carbohydrates / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D015497:HIV-1 / Q000502:physiology*; D009682:Magnetic Resonance Spectroscopy; D009705:Nucleosides / Q000737:chemistry / Q000494:pharmacology*; D009943:Organophosphorus Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D002241:Carbohydrates; D009705:Nucleosides; D009943:Organophosphorus Compounds
vernacular_title: Novye 5'-fosfonaty modifitsirovannykh po sakharnomu ostatku nukleozidovkak ingibitory produktsii VICh.