title: The long-term success of fresh, small fragment osteochondral allografts used for intraarticular post-traumatic defects in the knee joint.
abstract: Ninety-two fresh osteochondral allografts were implanted in 91 patients with posttraumatic osteoarticular defects of the knee joint. These patients have been prospectively followed since 1972. An analysis of long-term survival of these grafts has been performed to determine their success rates: 75% at 5 years, 64% at 10 years, and 63% at 14 years. An evaluation was made between unipolar grafts, which involve only one surface of the compartment, and bipolar grafts, which involve both surfaces. The unipolar grafts had a lower failure rate at all time periods compared to bipolar grafts, with 76% survival at 5 years, 69% at 10 years, and 67% at 14 years. While investigating other factors that might affect the survival of the fresh osteochondral allografts, we calculated the influence of the anatomical location of the graft, patient sex, and patient age. There was no meaningful impact on allograft survival by either the location of the allograft or the sex of the patient. However, there was a significant effect on allograft longevity in terms of patient age, with patients under age 60 doing better. The best indication for the use of unipolar fresh osteochondral allografts is for posttraumatic defects in relatively young, active patients. Joint malalignment should be corrected to achieve best results.
authors.affiliation: Mount Sinai Hospital, Div of Orthopedic Surgery, Toronto, Ontario, Canada.
authors.forename: M N
authors.initials: MN
authors.lastname: Mahomed
authors.forename: R J
authors.initials: RJ
authors.lastname: Beaver
authors.forename: A E
authors.initials: AE
authors.lastname: Gross
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D016025:Bone Transplantation; D002358:Cartilage, Articular / Q000637:transplantation*; D005260:Female; D006085:Graft Survival; D006801:Humans; D007718:Knee Injuries / Q000000981:diagnostic imaging / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011859:Radiography; D012737:Sex Factors