Systemic lupus erythematosus induced by isoniazid.
The case is described of a 73 year old man who presented with a lupus-like syndrome related to treatment with isoniazid and had IgG antinuclear antibodies against the nucleo-histone complex (H2A-H2B)-DNA. After a short course of treatment with prednisone and discontinuation of isoniazid the patient's lupus symptoms resolved and a gradual decrease in antibodies to (H2A-H2B)-DNA occurred. This case suggests that isoniazid is capable of inducing an autoantibody specificity associated with drug related lupus.
Salazar-Páramo
M
M
Department of Immunology and Rheumatology, Hospital General de Occidente de la S.S., Zapopan, Jalisco, Mexico.
Rubin
R L
RL
García-De La Torre
I
I
D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis; D006657:Histones / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007538:Isoniazid / Q000009:adverse effects*; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000188:drug therapy / Q000276:immunology; D008297:Male; D011241:Prednisone / Q000627:therapeutic use
D000974:Antibodies, Antinuclear; D006657:Histones; D007074:Immunoglobulin G; D007538:Isoniazid; D011241:Prednisone