title: CDw 60 antibodies bind to acetylated forms of ganglioside GD3.
abstract: Four monoclonal antibodies, M-T21, M-T32, M-T41 and UM4D4, which belong to the new CDw 60 cluster of antibodies specific for a subpopulation of human T-lymphocytes, were found to bind mainly to acetylated forms of ganglioside GD3. After O-deacetylation of the antigen, binding was reduced ("M-T"-antibodies) or abolished (UM4D4).
authors.affiliation: GBF-Gesellschaft für Biotechnologische Forschung mbH, Braunschweig, FRG.
authors.forename: B
authors.initials: B
authors.lastname: Kniep
authors.forename: J
authors.initials: J
authors.lastname: Peter-Katalinić
authors.forename: W
authors.initials: W
authors.lastname: Flegel
authors.forename: H
authors.initials: H
authors.lastname: Northoff
authors.forename: E P
authors.initials: EP
authors.lastname: Rieber
mesh_terms: D000107:Acetylation; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000918:Antibody Specificity; D015703:Antigens, CD / Q000276:immunology*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D002240:Carbohydrate Sequence; D002851:Chromatography, High Pressure Liquid; D005732:Gangliosides / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; C064741:CDw60 antigen; D005732:Gangliosides; C026226:ganglioside, GD3