title: Evaluation of the in vivo effect of naproxen on zidovudine pharmacokinetics in patients infected with human immunodeficiency virus.
abstract: OBJECTIVE
  To determine if therapeutic doses of naproxen affect the in vivo disposition of zidovudine.
  
  
  METHODS
  This was designed as a randomized, two-period, two-treatment, crossover study. The patients were 12 men infected with human immunodeficiency virus who had acquired immunodeficiency syndrome (AIDS) or AIDS-related complex. On two separate occasions 14 days apart, patients received either zidovudine alone (200 mg every 4 hours while awake) or zidovudine (200 mg every 4 hours while awake) and naproxen (500 mg every 12 hours for 4 days). On the morning of the fifth day, each patient received the final dose of each regimen and blood and urine were serially collected for 8 hours. Pharmacokinetic parameters (area under the serum concentration-time curve [AUC], maximum plasma concentration, terminal half-life, renal clearance, and urinary recovery) were assessed for zidovudine and its glucuronide metabolite.
  
  
  RESULTS
  Naproxen had no significant effect (< 10% difference between treatment means, p > 0.15, ANOVA) on the above pharmacokinetic parameters for both zidovudine and its metabolite. Although the power of the study to detect these small differences was < 80% at the 5% significance level, differences ranging from 12.6% for AUC to 38.8% for urinary recovery could be detected with 80% power.
  
  
  CONCLUSIONS
  Therapeutic doses of naproxen do not significantly affect the pharmacokinetic disposition of zidovudine.
authors.affiliation: Department of Medicine, Ottawa General Hospital, Ontario, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Sahai
authors.forename: K
authors.initials: K
authors.lastname: Gallicano
authors.forename: G
authors.initials: G
authors.lastname: Garber
authors.forename: A
authors.initials: A
authors.lastname: Pakuts
authors.forename: N
authors.initials: N
authors.lastname: Hawley-Foss
authors.forename: L
authors.initials: L
authors.lastname: Huang
authors.forename: I
authors.initials: I
authors.lastname: McGilveray
authors.forename: D W
authors.initials: DW
authors.lastname: Cameron
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002851:Chromatography, High Pressure Liquid; D004347:Drug Interactions; D015658:HIV Infections / Q000188:drug therapy* / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009288:Naproxen / Q000494:pharmacology*; D011863:Radioimmunoassay; D015215:Zidovudine / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D015215:Zidovudine; D009288:Naproxen