The retinoblastoma protein and the regulation of cell cycling.
Increasing attention has been focused on how the retinoblastoma (RB) protein regulates cell growth. Recent evidence indicates that it is a substrate for phosphorylation by cyclin-dependent kinase-cyclin complexes and suggests that this phosphorylation modulates the ability of this protein to regulate transit through the cell cycle, perhaps in its G1 phase.
Cobrinik
D
D
Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts, Institute of Technology, Cambridge 02142-1479.
Dowdy
S F
SF
Hinds
P W
PW
Mittnacht
S
S
Weinberg
R A
RA
D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D002455:Cell Division; D016213:Cyclins / Q000502:physiology; D016161:Genes, Retinoblastoma / Q000502:physiology; D006801:Humans; D010766:Phosphorylation; D016160:Retinoblastoma Protein / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D016213:Cyclins; D016160:Retinoblastoma Protein