[Evoked potentials following cerebral ischemia in the rat: the effect of the stimulus frequency].
EEG and somatosensory evoked potentials were recorded in anesthetized rats before and up to 24 h after 30 min of global forebrain ischemia. Before ischemia, SEP (sweep time 1000 ms) included primary (N25P50) components and late potentials of low amplitude. During ischemia, SEP and EEG were isoelectric. During postischemic recirculation SEP evoked by stimulation at 1.0 Hz remained severely suppressed for 24 h, although long-latency potentials (> 100 ms) recovered. Using a very low stimulation frequency of 0.1 Hz, late components strongly increased in amplitude and the overall evoked activity in the averaged post-stimulus-EEG reached 90% of control. These results demonstrate that the SEP evoked at very low stimulation frequency may serve as an early indicator of functional brain recovery after prolonged cerebro-circulatory arrest.
Kocher
M
M
Abteilung für experimentelle Neurologie, Max-Planck-Institut für neurologische Forschung.
Miyazawa
T
T
Bauer
R
R
Hossmann
K A
KA
D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology*; D004569:Electroencephalography; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
Evozierte Potentiale nach zerebraler Ischämie der Ratte: Einfluss der Reizfrequenz.