New bioactive metabolites from a freshwater isolate of the fungus Kirschsteiniothelia sp.
The new cytotoxic naphthoquinone dimer kirschsteinin [5], two new chlorinated diphenyl ethers 8 and 9, three known naphthoquinone derivatives 1, 2, and 7, a monoacetyl derivative of 2, and the (-)-enantiomer of O-methylasparvenone [4], have been isolated from a previously undescribed species of Kirschsteiniothelia. The structures of these compounds were assigned primarily by nmr studies and by spectral comparisons.
Poch
G K
GK
Department of Chemistry, University of Iowa, Iowa City 52242.
Gloer
J B
JB
Shearer
C A
CA
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry / Q000378:metabolism*; D001412:Bacillus subtilis / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009285:Naphthoquinones / Q000302:isolation & purification / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D009285:Naphthoquinones