title: Preoperative corticosteroids. A contraindication to lung transplantation?
abstract: Regular preoperative application of corticosteroids has been considered as a contraindication to lung transplantation for fear of an increased risk of postoperative morbidity and mortality. Recently, however, we have accepted patients for transplantation in whom treatment with steroid medication could not be terminated preoperatively. Up to February 1991, 27 unilateral and bilateral transplantations in 26 patients were analyzed. Corticosteroid therapy was discontinued at least three months prior to transplantation in 13 patients (group 1), whereas in 14 cases, the patients continued their daily corticosteroid therapy to the time of transplantation (prednisolone, 0.1 to 0.3 mg/kg/day; group 2). There were no significant differences between the groups with respect to sex, age, diagnosis, or type of transplantation. One limited bronchial dehiscence occurred; the incidence of postoperative bronchial stenosis was identical in both cohorts; one patient died in each group. In conclusion, no increased morbidity or mortality could be found following lung transplantation with regular preoperative administration of prednisolone up to 0.3 mg/kg/day. Thus, patients who cannot be weaned from their steroid medication but who otherwise are acceptable candidates should not be excluded from lung transplantation.
authors.affiliation: Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Germany.
authors.forename: H J
authors.initials: HJ
authors.lastname: Schäfers
authors.forename: T O
authors.initials: TO
authors.lastname: Wagner
authors.forename: S
authors.initials: S
authors.lastname: Demertzis
authors.forename: M
authors.initials: M
authors.lastname: Hamm
authors.forename: T
authors.initials: T
authors.lastname: Wahlers
authors.forename: J
authors.initials: J
authors.lastname: Cremer
authors.forename: A
authors.initials: A
authors.lastname: Haverich
mesh_terms: D000293:Adolescent; D000328:Adult; D000714:Anastomosis, Surgical; D001980:Bronchi / Q000601:surgery; D001982:Bronchial Diseases / Q000209:etiology; D003251:Constriction, Pathologic; D000075202:Contraindications; D005260:Female; D006801:Humans; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects*; D012307:Risk Factors; D013529:Surgical Wound Dehiscence
chemical_list: D011239:Prednisolone