Identification of the eleventh complementation group of UV-sensitive excision repair-defective rodent mutants.
The drug-sensitive mutant UVS1, isolated from the Chinese hamster cell line CHO9, was previously found to complement the UV sensitivity of the excision repair-defective rodent mutants representative of groups 1 to 8 (Hata et al., Cancer Res., 51: 195-198, 1991; M. Numata et al., personal communication). Recently two new complementation groups of UV-sensitive CHO mutants, e.g., groups 9 and 10, have been identified (Stefanini et al., Cancer Res., 51: 3965-3971, 1991). In this paper we demonstrate that the repair defect in UVS1 cells is genetically different from those present in the mutants CHO7PV and CHO4PV, representing groups 9 and 10, respectively. Therefore, UVS1 represents a new complementation group of UV-sensitive rodent cell lines, the eleventh group.
Riboni
R
R
Istituto di Genetica Biochimica ed Evoluzionistica C.N.R., Pavia, Italy.
Botta
E
E
Stefanini
M
M
Numata
M
M
Yasui
A
A
D000818:Animals; D016466:CHO Cells / Q000528:radiation effects*; D006224:Cricetinae; D004247:DNA / Q000528:radiation effects*; D004260:DNA Repair; D009154:Mutation; D014466:Ultraviolet Rays
D004247:DNA