title: Inhaled steroids modify bronchial responses to hyperosmolar saline.
abstract: We investigated the effects of inhaled beclomethasone dipropionate (BDP) on airway sensitivity (provocative dose producing a 20% fall in forced expiratory volume in one second (FEV1) from baseline (PD20)) and reactivity (slope of the dose-response curve) to inhaled aerosols of hyperosmolar (4.5%) saline, and histamine or methacholine. This was an open study on 13 patients referred to the laboratory by their respiratory physician for investigation of their asthma. These challenges were performed on separate days before (initial visit) and 8.8 +/- 0.8 (SD) weeks (range 5.6-12.4 weeks) after (visit 1) a treatment period with BDP (dose range 600-1,500 micrograms.day-1). At visit 1 there was a significant reduction in sensitivity to 4.5% NaCl and histamine/methacholine and in reactivity. The PD20 increased 5.6 fold for 4.5% NaCl and 4.1 fold for histamine/methacholine. All patients remained responsive to histamine/methacholine and a fall in FEV1 > 20% to 4.5% saline was documented in 10 of the 13 patients. We conclude that treatment with BDP reduces sensitivity and reactivity to both osmotic and pharmacological challenge.
authors.affiliation: Dept of Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
authors.forename: L T
authors.initials: LT
authors.lastname: Rodwell
authors.forename: S D
authors.initials: SD
authors.lastname: Anderson
authors.forename: J P
authors.initials: JP
authors.lastname: Seale
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000503:physiopathology*; D001507:Beclomethasone / Q000008:administration & dosage / Q000494:pharmacology*; D001980:Bronchi / Q000187:drug effects*; D001985:Bronchial Provocation Tests / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects*; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D008297:Male; D016210:Methacholine Chloride / Q000494:pharmacology; D009994:Osmolar Concentration; D010865:Pilot Projects; D012965:Sodium Chloride / Q000737:chemistry / Q000494:pharmacology
chemical_list: D016210:Methacholine Chloride; D012965:Sodium Chloride; D006632:Histamine; D001507:Beclomethasone