title: Comparative study between 4-aminobutyrate-2-oxoglutarate aminotransferase (GABA-T) from rat forebrain and cerebellum.
abstract: In this study differences in the biochemical properties of 4-aminobutyric acid aminotransferase (GABA-T) from forebrain and cerebellum were detected. These differences may be related to: a) the characteristics of the catalytic site, b) the substrate affinities and c) their pyridoxal-phosphate requirements which suggests that PLP could be a physiological regulator of these forms of brain GABA-T.
authors.affiliation: Instituto de Bioquimica (Centro mixto C.S.I.C.-U.C.M.), Facultad de Farmacia, Ciudad Universitaria, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Arce
authors.forename: S
authors.initials: S
authors.lastname: Cañadas
authors.forename: M
authors.initials: M
authors.lastname: De Vicente
authors.forename: M J
authors.initials: MJ
authors.lastname: Oset-Gasque
authors.forename: M P
authors.initials: MP
authors.lastname: González
mesh_terms: D000612:4-Aminobutyrate Transaminase / Q000378:metabolism*; D000625:Aminooxyacetic Acid / Q000494:pharmacology; D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology; D001923:Brain Chemistry; D002531:Cerebellum / Q000201:enzymology*; D016548:Prosencephalon / Q000201:enzymology*; D011732:Pyridoxal Phosphate / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D000625:Aminooxyacetic Acid; D001224:Aspartic Acid; D005680:gamma-Aminobutyric Acid; D011732:Pyridoxal Phosphate; D000612:4-Aminobutyrate Transaminase