title: Displacement of rifampicin bound to serum proteins by addition of levamisole.
abstract: We have studied, by ultrafiltration, the interactions between rifampicin (15 and 30 microM) and levamisole (7 microM) since both drugs may be associated for the treatment of brucellosis. We can observe a statistically significant increase in the free plasmatic fraction of rifampicin at the studied concentration of levamisole, which indicated that levamisole reduced rifampicin bound to proteins (290 and 250%, respectively).
authors.affiliation: Departamento de Bioquímica, Colegio Universitario de Medicina, Soria, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Pérez-Gallardo
authors.forename: M L
authors.initials: ML
authors.lastname: Blanco
authors.forename: H
authors.initials: H
authors.lastname: Soria
authors.forename: J F
authors.initials: JF
authors.lastname: Escanero
mesh_terms: D001798:Blood Proteins / Q000378:metabolism*; D004347:Drug Interactions; D006801:Humans; D007978:Levamisole / Q000494:pharmacology*; D011485:Protein Binding / Q000187:drug effects; D012293:Rifampin / Q000378:metabolism*
chemical_list: D001798:Blood Proteins; D007978:Levamisole; D012293:Rifampin