title: Increased monoamine turnover in the subfornical organ area following body fluid depletion.
abstract: To clarify whether monoaminergic inputs to the subfornical organ (SFO) area participate in fluid regulatory systems, we examined the effects of body fluid depletion on monoamine turnover in the region of the SFO using microdialysis techniques in rats. An iso-osmotic reduction of fluid volume following subcutaneous treatment with polyethylene glycol (PEG) significantly increased dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), and 5-hydroxyindoleacetic acid (5-HIAA) concentrations in the SFO area. 5-hydroxytryptamine (5-HT) in the SFO area could be detected after the PEG treatment, while 5-HT was undetectable before the treatment. The data imply that both dopaminergic and serotonergic systems in the SFO area may be involved in controlling body fluid balance.
authors.affiliation: Research Laboratories, Torii Co. Ltd., Chiba, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kariya
authors.forename: J
authors.initials: J
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Hori
authors.forename: M
authors.initials: M
authors.lastname: Oda
authors.forename: M
authors.initials: M
authors.lastname: Iwaki
authors.forename: M
authors.initials: M
authors.lastname: Nomura
mesh_terms: D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D001826:Body Fluids / Q000502:physiology*; D003956:Dialysis; D008297:Male; D011092:Polyethylene Glycols / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013356:Subfornical Organ / Q000737:chemistry / Q000378:metabolism*
chemical_list: D015306:Biogenic Monoamines; D011092:Polyethylene Glycols