Assignment of a novel protein tyrosine phosphatase gene (Hcph) to mouse chromosome 6.
Hematopoietic cell phosphatase (Hcph) was identified by amplification of conserved protein tyrosine phosphatase sequences from a myeloid cell line and is predominantly expressed in hematopoietic cells. Hcph is unique in containing two, tandemly repeated, src-homology 2 domains in the amino terminal region of the phosphatase. Using a genomic probe in interspecific backcross analysis, the murine Hcph gene maps to mouse Chromosome 6 and is tightly linked to the Tnfr-2 and Ly-4 genes.
Yi
T
T
Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.
Gilbert
D J
DJ
Jenkins
N A
NA
Copeland
N G
NG
Ihle
J N
JN
D000818:Animals; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D003433:Crosses, Genetic; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*
D017027:Protein Tyrosine Phosphatases