title: Effect of preperfusion of lead and aminophylline on digoxin cardiotoxicity.
abstract: An attempt has been made to investigate the cardiotoxicity of an interaction of Lead acetate (LA), Aminophylline (APH) and Digoxin (DGN), employing an isolated frog heart preparation. While DGN-Cardiotoxicity was potentiated by LA-preperfusion, it was antagonized by APH-preperfusion as revealed by data reflecting the mean DGN perfusion time (Sec) and mean DGN exposure (microgram/10 mg heart weight) for cardiac arrest. In an experimental group involving interaction of LA, DGN and APH, preperfusion of APH has significantly diminished but not fully abolished LA-induced potentiation of DGN-cardiotoxicity. On the other hand, perfusion of APH after LA resulted not only in annulment of LA-induced potentiation but also in an eventual residual protective effect of APH. It was striking that simultaneous preperfusion of APH and LA led to exacerbation of LA-induced potentiation. The results of this interaction study involving two widely prescribed cardioactive drugs, are considered to be of immense pharmaco-toxicological interest.
authors.affiliation: Department of Pharmacology and Environmental Toxicology, Dr. ALM P.G. Institute of Basic Medical Sciences, University of Madras, Taramani, India.
authors.forename: M S
authors.initials: MS
authors.lastname: Krishnamoorthy
authors.forename: P
authors.initials: P
authors.lastname: Muthu
authors.forename: T S
authors.initials: TS
authors.lastname: Kumaravel
mesh_terms: D000628:Aminophylline / Q000633:toxicity*; D000818:Animals; D004077:Digoxin / Q000633:toxicity*; D004347:Drug Interactions; D004357:Drug Synergism; D006321:Heart / Q000187:drug effects*; D006331:Heart Diseases / Q000139:chemically induced*; D066298:In Vitro Techniques; D007854:Lead / Q000633:toxicity*; D010477:Perfusion; D011898:Ranidae; D013997:Time Factors
chemical_list: D000628:Aminophylline; D007854:Lead; D004077:Digoxin