[Participation of protein synthesis in brain cell structures in the action of antifeins on long-term memory].
Incorporation of 3H-leucine into proteins of rat brain cell structures during application of antifeins (compounds of alternative action on memory processes) has been studied. No correlation was observed between changes in protein synthesis in nuclei, mitochondria, components of endoplasmic reticulum and memory effects of ethyl-, allyl- and propylnorantifeins. Only M1 and M2-demethylated structural analogs of ethylnorantifeins (exerting the most effective action on RNA synthesis and retention of conditional reflexes) enhanced the synaptosomal protein synthesis.
Reĭkhardt
B A
BA
Beliavtseva
L M
LM
Kulikova
O G
OG
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D002467:Cell Nucleus / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D008928:Mitochondria / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism
D007093:Imidazoles; D009419:Nerve Tissue Proteins; C014337:Antiphein
Uchastie sinteza belkov tsitostruktur golovnogo mozga v deĭstvii antifeinov na dolgovremennuiu pamiat'.