[Liposomal amphotericin B in the treatment of candida infection in a 3-month-old infant].
Amphotericin B (Amph-B) is the treatment of choice for systemic fungal infections. The application of high doses is limited due to the high incidence of acute side effects (fever, chills) and organ toxicity (reduction in glomerular filtration rate, renal tubular damage). Amph-B was applied without success in a three months old infant, who suffered from systemic candidiasis. After a change to high doses (3-5 mg/kg/day) of liposomal Amph-B (Amph-lip) rapid improvement of the patient's condition occurred and the pulmonary lesions disappeared during six weeks of treatment (total dose 185.5 mg/kg). Acute side effects or renal function abnormalities did not occur. The reported case indicates that the application of high doses of Amph-lip is an alternative to conventional Amph-B in treatment of systemic fungal infections.
Emminger
W
W
St. Anna Kinderspital, Wien, Osterreich.
Innerhofer
A
A
Helfert
A
A
Kummer
M
M
Gadner
H
H
D000666:Amphotericin B / Q000008:administration & dosage* / Q000009:adverse effects; D002177:Candidiasis / Q000188:drug therapy*; D003428:Cross Infection / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers; D005260:Female; D016469:Fungemia / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D008081:Liposomes
D004337:Drug Carriers; D008081:Liposomes; D000666:Amphotericin B
Liposomales Amphotericin B zur Behandlung einer Candidasepsis bei einem drei Monate alten Säugling.