A new carbamazepine metabolite in uraemic filtrate.
1. After administration of carbamazepine (Tegretal) to an epileptic patient suffering also from uraemia, a previously unknown metabolite was detected in the haemofiltrate. It was identified as the 10,11-dihydro-10-hydroxy-carbamazepine-O-beta-glucuronide. 2. Its identification was accomplished mainly by electron impact (EI), liquid secondary ion (LSI) mass spectrometry and n.m.r. spectroscopy.
Beyer
C
C
Lehrstuhl Organische Chemie I, Universität Bayreuth, Germany.
Spiteller
G
G
D002220:Carbamazepine / Q000378:metabolism*; D005260:Female; D005965:Glucuronates / Q000378:metabolism; D006801:Humans; D013058:Mass Spectrometry; D008875:Middle Aged; D014511:Uremia / Q000378:metabolism*
D005965:Glucuronates; D002220:Carbamazepine