title: Ontogenic characteristics of cavian aldolase.
abstract: In order to extend the available information on the ontogenic significance of the interactions between aldolase and cellular structure, the nature and extent of these associations have been studied in the tissues of the guinea pig during development, along with analyses of the isozyme status in the bound and soluble compartments. In all tissues investigated, a significant degree of binding was evident, along with a considerable variation in the degree of association of aldolase with structure during development. Binding was particularly extensive in the early foetal stages and, in general, binding preference was directed towards A-type activity over the B- and C-type of enzyme. The significance of these ontogenic phenomena have been discussed in relation to the variations in phenotype of individual tissues during maturation and the metabolic correlations of this biphasic micro-organization.
authors.affiliation: Division of Science and Technology, Griffith University, Brisbane, Australia.
authors.forename: W
authors.initials: W
authors.lastname: Murrell
authors.forename: D
authors.initials: D
authors.lastname: Crane
authors.forename: C
authors.initials: C
authors.lastname: Masters
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology / Q000254:growth & development; D005333:Fetus / Q000201:enzymology; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism*; D006128:Growth / Q000502:physiology*; D006168:Guinea Pigs; D006321:Heart / Q000254:growth & development; D007527:Isoenzymes / Q000378:metabolism; D007668:Kidney / Q000201:enzymology / Q000254:growth & development; D008099:Liver / Q000201:enzymology / Q000254:growth & development; D024510:Muscle Development; D009132:Muscles / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D012995:Solubility; D014018:Tissue Distribution
chemical_list: D007527:Isoenzymes; D005634:Fructose-Bisphosphate Aldolase