Soluble interleukin-2 receptor levels in lupus nephritis.
Soluble interleukin-2 receptor (IL-2R) levels were measured and correlated prospectively with clinical, histologic and serologic findings over a 9-month period in 62 lupus patients. Initially, 39 patients had clinical nephritis and 23 patients did not have nephritis. The 62 lupus patients has significantly higher IL-2R than 15 normal controls, most of this difference attributable to patients with nephritis. During lupus nephritis flare 9 of 10 patients showed significant elevations of IL-2R while only 6 of the 10 patients showed either elevation of anti-DNA antibody or decrease in CH50. During disease remission or stable clinical activity changes in IL-2R levels paralleled changes in anti-DNA antibody and CH50. Nephritis patients with cellular proliferative histology had significantly higher IL-2R levels than those with membranous or mesangial nephropathy. IL-2R correlated strongly with histologic activity and chronicity indices, IgG and C3 deposition whereas anti-DNA antibody and CH50 levels did not. IL-2R levels did not correlate with serum creatinine suggesting that elevations of IL-2R were not simply due to decreased clearance. These observations suggest that serum IL-2R level is a useful marker of disease activity in lupus nephritis and may serve as a helpful adjunct in management of this disorder.
Laut
J
J
Department of Medicine, Montefiore Medical Center, Bronx, New York 10467.
Senitzer
D
D
Petrucci
R
R
Sablay
L B
LB
Barland
P
P
Glicklich
D
D
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D003165:Complement System Proteins / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007668:Kidney / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000097:blood; D008181:Lupus Nephritis / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D011446:Prospective Studies; D015375:Receptors, Interleukin-2 / Q000032:analysis*
D000974:Antibodies, Antinuclear; D015415:Biomarkers; D015375:Receptors, Interleukin-2; D003165:Complement System Proteins