Metabolic abnormalities of mitochondrial redox potential in postburn multiple system organ failure.
Forty-five burn patients underwent sequential assays for plasma acetoacetate and beta-hydroxybutyrate concentrations as well as plasma amino acid levels. Those patients who went on to develop multiple system organ failure were noted to have a decrease in their acetoacetate concentration with time, whereas there was no change in those patients who failed to develop multiple system organ failure. The plasma concentration of beta-hydroxybutyrate was not altered by multiple system organ failure. In addition, the plasma acetoacetate/beta-hydroxybutyrate ratio was found to be directly related to the plasma concentration of branched chain amino acids and inversely related to the concentration of aromatic amino acids.
Dong
Y L
YL
Trauma Center, Postgraduate Medical College, Beijing, China.
Sheng
C Y
CY
Herndon
D N
DN
Waymack
J P
JP
D000090:Acetoacetates / Q000097:blood; D000597:Amino Acids, Branched-Chain / Q000097:blood; D002056:Burns / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D006885:Hydroxybutyrates / Q000097:blood; D007657:Ketone Bodies / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D009102:Multiple Organ Failure / Q000378:metabolism*; D010084:Oxidation-Reduction
D000090:Acetoacetates; D000597:Amino Acids, Branched-Chain; D006885:Hydroxybutyrates; D007657:Ketone Bodies; C016635:acetoacetic acid