The 5-HT1A agonist 8-OH-DPAT attenuates the satiating action of cholecystokinin.
To investigate the dependence of the satiating action of cholecystokinin (CCK) on serotonergic action at central 5-HT receptors, we examined the effect of systemic pretreatment with 8-OH-DPAT (a 5-HT1A agonist that decreases central 5-HT synthesis and release via an action at somatodendritic autoreceptors in the brainstem raphe) on the suppression of food intake induced by systemic administration of cholecystokinin octapeptide (CKK-8). 8-OH-DPAT significantly attenuated the satiating action of CKK-8. This result is consistent with the hypothesis that peripherally acting CCK recruits central serotonergic processes to elicit normal satiety.
Poeschla
B
B
Department of Psychiatry, Cornell University Medical College, White Plains, NY.
Gibbs
J
J
Simansky
K J
KJ
Smith
G P
GP
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000818:Animals; D002766:Cholecystokinin / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects; D008297:Male; D011187:Posture; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000187:drug effects; D012528:Satiety Response / Q000187:drug effects*; D012701:Serotonin / Q000502:physiology
D011985:Receptors, Serotonin; D012701:Serotonin; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D002766:Cholecystokinin