Fibrinogen and antithrombin III blood levels fluctuations during isoniazid or isoniazid plus rifampicin administration.
Nineteen randomized patients, treated with isoniazid (INH, CAS 54-85-3) for tuberculosis chemoprophylaxis or isoniazid plus rifampicin (RMP, CAS 13292-46-1) combination for tuberculosis therapy, were studied in order to explore the effects of these drugs on fibrinogen and antithrombin III blood levels. Other hepatic biology indices were also measured (aminotransferases, alkaline phosphatase, prothrombin time etc). The results suggested a relationship between INH or INH + RMP administration and fibrinogen as well as antithrombin III blood levels. The data indicate a protective effect of the RMP synchronous administration (by enzyme induction mechanisms) in the preservation of fibrinogen blood levels.
Farmakis
M
M
Intensive Care Unit of Metaxa Memorial Hospital, Piraeus, Greece.
Travlou
O
O
Aroni
S
S
Fertakis
A
A
D000328:Adult; D000990:Antithrombin III / Q000378:metabolism*; D001777:Blood Coagulation / Q000187:drug effects; D004338:Drug Combinations; D004798:Enzymes / Q000097:blood; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012293:Rifampin / Q000009:adverse effects* / Q000627:therapeutic use; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000188:drug therapy
D004338:Drug Combinations; D004798:Enzymes; D000990:Antithrombin III; D005340:Fibrinogen; D007538:Isoniazid; D012293:Rifampin