The enantiomeric resolution of ciprofibrate and related compounds by HPLC using chiral stationary phases.
The attempted chromatographic resolution of the drug ciprofibrate and a range of related compounds, containing the chiral moiety 2,2-dichlorocyclopropylbenzene, using five different chiral stationary phases is described. Aqueous mobile phases were used throughout and the successful separation of nine out of 12 pairs of enantiomers was achieved. Structures remote from the chiral centre were seen to affect chiral recognition.
Anderson
N H
NH
Sterling Winthrop Pharmaceuticals Research Division, Alnwick, Northumberland, UK.
Johnston
D
D
Vojvodic
P R
PR
D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D002995:Clofibric Acid / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry; D003505:Cyclodextrins; D003912:Dextrins / Q000737:chemistry; D058607:Fibric Acids; D000960:Hypolipidemic Agents / Q000032:analysis*; D009961:Orosomucoid / Q000737:chemistry; D013237:Stereoisomerism
D003505:Cyclodextrins; D003912:Dextrins; D058607:Fibric Acids; D000960:Hypolipidemic Agents; D009961:Orosomucoid; D002995:Clofibric Acid; D002482:Cellulose; C024671:cellulose triacetate; C019304:ciprofibrate