Preservation of energy metabolites by carnitine in the mouse brain under ischemia.
Ischemia (decapitation) caused marked changes of energy metabolites in the mouse brain. However, the changes were clearly less severe, when the mouse was pre-treated with L-carnitine. This suggests that L-carnitine may protect the brain from the ischemic attack. Since D-carnitine showed a similar effect, the effects may be due to mechanism(s) other than the 'classical' function of carnitine.
Matsuoka
M
M
Department of Environmental Toxicology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Igisu
H
H
D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism / Q000517:prevention & control*; D002331:Carnitine / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects*; D051379:Mice; D013237:Stereoisomerism
D002331:Carnitine