title: Synthesis and some pharmacological properties of 1,2-amino ethers with natural monoterpene structures.
abstract: Synthesis and physicochemical and pharmacological properties of 10 analogs of 2-[2-(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethoxy]N, N-diethylamino ethane (3) have been described. The compounds possess toxicity close to or lower than the parent compound--myrtecaine, have no antiarrhythmic activity but some of them (15, 16, 22, 24), similarly as compound 3, show quite strong local anesthetic action.
authors.affiliation: Institute of Organic and Physical Chemistry, Polytechnical University, Wrocław, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Siemieniuk
authors.forename: H
authors.initials: H
authors.lastname: Szałkowska-Pagowska
authors.forename: S
authors.initials: S
authors.lastname: Lochyński
authors.forename: K
authors.initials: K
authors.lastname: Piatkowski
authors.forename: B
authors.initials: B
authors.lastname: Filipek
authors.forename: J
authors.initials: J
authors.lastname: Krupińska
authors.forename: R
authors.initials: R
authors.lastname: Czarnecki
authors.forename: T
authors.initials: T
authors.lastname: Librowski
authors.forename: I
authors.initials: I
authors.lastname: Szymańska
mesh_terms: D000772:Anesthesia, Local; D000779:Anesthetics, Local / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000517:prevention & control; D001767:Blinking / Q000187:drug effects; D003315:Cornea / Q000187:drug effects; D004562:Electrocardiography / Q000187:drug effects; D006168:Guinea Pigs; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D013729:Terpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*
chemical_list: D000779:Anesthetics, Local; D013729:Terpenes; C011940:myrtecaine