[The role of interleukin-6 in Crow-Fukase syndrome].
We measured serum interleukin-6 (IL-6) levels in 14 patients with Crow-Fukase syndrome. Five out of 14 patients with Crow-Fukase syndrome showed high serum IL-6 levels above 10 pg/ml, which was statistically significant in comparison with control subjects with other neurological diseases. Serial studies of serum IL-6 levels in two patients revealed the increase before the exacerbation of clinical symptoms of edema, and pleural or cardiac effusion, and the fall after the treatment by high dose pulsed methylprednisolone. We suggest that serum IL-6 level appears to be a useful marker to predict its exacerbation. Also we performed immunohistochemical study on cutaneous angioma from three Crow-Fukase syndrome patients using anti-IL-6 antibody. The cytoplasm of endothelial cells of cutaneous angioma from two patients was positively stained, which might imply the abnormality of endothelial cells in Crow-Fukase syndrome.
Hitoshi
S
S
Department of Neurology, Japanese Red Cross Medical Center.
Sato
K
K
Suzuki
K
K
Sato
K
K
Sakuta
M
M
D004730:Endothelium, Vascular / Q000378:metabolism; D006391:Hemangioma / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D015850:Interleukin-6 / Q000378:metabolism / Q000502:physiology*; D016878:POEMS Syndrome / Q000378:metabolism*; D012878:Skin Neoplasms / Q000378:metabolism
D015850:Interleukin-6