[Calcium and calcium-channel blockers in the healing of an experimental myocardial infarct].
It has been shown in experiments on 36 dogs with experimental myocardial infarction (MI) that the effect of calcium and blockers of calcium channels largely depends on the initial condition of reactivity and is realized via changes in lipid peroxidation (LPO). In MI, calcium enhances necrotic processes whereby aggravating disorders in its healing in case of high reactivity and returns them to normal, thus contributing to optimization of its healing in animals with low reactivity. Calcium channels blockers attenuate necrotic processes associated with MI and lead to its better healing in the presence of high reactivity and aggravate disorders in its healing in animals with low reactivity. Consideration of the body reactivity, the differentiated use of calcium drugs and calcium channels blockers should be regarded as an effective approach to optimization of the healing of complicated forms of MI.
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D000632:Aminopyrine; D000818:Animals; D002118:Calcium / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D008070:Lipopolysaccharides; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D011749:Pyrogens; D013997:Time Factors
D002121:Calcium Channel Blockers; D008070:Lipopolysaccharides; D011749:Pyrogens; C009136:pyrogenal; D000632:Aminopyrine; D002118:Calcium
Kal'tsiĭ i blokatory kal'tsievykh kanalov pri zazhivlenii éksperimental'nogo infarkta miokarda.