title: Neutralization potency of Russell's viper venom toxoid antivenom, as compared with standard antivenom.
abstract: Rabbits were immunized with gamma (gamma) irradiated Russell's viper venom toxoid, adsorbed to aluminium phosphate adjuvant. Antibody (raised against toxoid inoculation) titer was compared to a commercial antivenom on the basis of its ability to neutralize hemorrhagic, necrotic and lethal effects of viper venom. Toxoid immunization (on day 0, 15 and 30) produced antivenom which showed approximately one-third antilethal, half antihemorrhagic and antinecrotic titers as compared to those of the commercial hyperimmunized, concentrated horse antivenom.
authors.affiliation: Department of Medicinal Entomology, Calcutta School of Tropical Medicine.
authors.forename: M
authors.initials: M
authors.lastname: Mandal
authors.forename: R N
authors.initials: RN
authors.lastname: Hati
authors.forename: A K
authors.initials: AK
authors.lastname: Hati
mesh_terms: D000818:Animals; D000997:Antivenins / Q000276:immunology*; D006470:Hemorrhage / Q000209:etiology / Q000517:prevention & control; D007928:Lethal Dose 50; D051379:Mice; D009336:Necrosis / Q000209:etiology / Q000517:prevention & control; D009500:Neutralization Tests; D011817:Rabbits; D014121:Toxoids / Q000276:immunology*; D014757:Viper Venoms / Q000037:antagonists & inhibitors* / Q000276:immunology / Q000633:toxicity
chemical_list: D000997:Antivenins; D014121:Toxoids; D014757:Viper Venoms