Valproate acute administration, EEG epileptic abnormalities, and ammonemia.
Acute, oral administration of 14.3 to 37.5 mg/kg magnesium valproate (peak serum concentrations, 65 to 139 micrograms/ml) increases spike-wave frequency at 2, 3, 4, and 5 hours postdrug, in the absence of hyperammonemia or significant correlations with ammonemia fluctuations. This observation suggests a direct role of valproate on neural activity.
Sannita
W G
WG
Center for Neuroactive Drugs, Institute of Neurophysiopathology of the University, Genoa, Italy.
D000293:Adolescent; D000328:Adult; D000641:Ammonia / Q000097:blood*; D004569:Electroencephalography; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D014635:Valproic Acid / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use
D014635:Valproic Acid; D000641:Ammonia