Hematologic toxicosis associated with doxorubicin administration in cats.
The hematologic toxicity of doxorubicin, 30 mg/m2 body surface area (BSA) every 21 days to a cumulative dose of 300 mg/m2, was evaluated in six cats. Complete blood and platelet counts were performed daily during the first treatment cycle. They were monitored before treatment for all remaining cycles, and at the average neutrophil nadir (day 8) starting with cycle 4. Significant poikilocytosis developed after the first treatment and remained throughout the study, although anemia did not occur. No other red blood cell abnormalities were seen. Platelet counts remained within the reference range throughout the first treatment cycle, but mild thrombocytopenia (88,000-288,000/uL) was found in 11.3% of subsequent complete blood counts (CBCs). Thrombocytosis was seen in 30.9% of CBCs. Neutropenia did not occur during the first treatment cycle although neutrophil counts did decrease, with the nadir occurring between days 8 and 11. All neutrophil counts returned to pretreatment values by day 14. Neutropenia was documented after 14 of 46 (30.4%) doxorubicin treatments, and was associated with fever in 5 cats (10.9%). All fevers responded to oral antibiotic therapy. Neutropenia that lasted more than 14 days developed in two cats, necessitating dosage reduction to 25 mg/m2 BSA. At the dose used in this study, doxorubicin administration was associated with acceptable hematologic toxicosis in most cats.
O'Keefe
D A
DA
Department of Veterinary Clinical Medicine, University of Illinois, Urbana 61801.
Schaeffer
D J
DJ
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects*; D002371:Cat Diseases / Q000139:chemically induced; D002415:Cats / Q000097:blood*; D004317:Doxorubicin / Q000633:toxicity*; D004912:Erythrocytes / Q000187:drug effects*; D005260:Female; D007958:Leukocyte Count / Q000187:drug effects / Q000662:veterinary; D008297:Male; D009503:Neutropenia / Q000139:chemically induced / Q000662:veterinary; D009504:Neutrophils / Q000187:drug effects*; D010976:Platelet Count / Q000187:drug effects / Q000662:veterinary; D013921:Thrombocytopenia / Q000139:chemically induced / Q000662:veterinary
D004317:Doxorubicin