Influence of triphasic oral contraceptives on blood rheology and hemostatic and metabolic patterns in young women. Results of a three-year study.
Long-term (three-year) variations in clinical, hemorheologic, hemostatic and blood lipid parameters were evaluated in 20 young healthy women taking a triphasic oral contraceptive. Body weight, arterial blood pressure, whole blood, plasma and serum viscosity, erythrocyte deformability, fibrinogen, fibronectin, alpha-2 macroglobulin, Von Willebrand factor antigen, triglycerides, nonesterified fatty acids, total and low density lipoprotein cholesterol, very low density lipoprotein, low density lipoprotein and apolipoprotein B levels remained unchanged throughout the study. However, high density lipoprotein cholesterol, high density lipoprotein and apolipoprotein A1 serum concentrations increased significantly during treatment. Long-term use of the triphasic oral contraceptive does not seem to adversely affect the blood rheology pattern or vascular endothelium function, which are the main factors responsible for the development of thromboembolic complications.
Solerte
S B
SB
Department of Internal Medicine, University of Pavia, Ospedale S. Margherita, Italy.
Fioravanti
M
M
Spinillo
A
A
Ferrari
E
E
Guaschino
S
S
D000328:Adult; D001769:Blood / Q000187:drug effects*; D001779:Blood Coagulation Factors / Q000032:analysis*; D002784:Cholesterol / Q000097:blood*; D003279:Contraceptives, Oral, Sequential / Q000494:pharmacology*; D005260:Female; D006403:Hematologic Tests; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D012212:Rheology
D001779:Blood Coagulation Factors; D003279:Contraceptives, Oral, Sequential; D008074:Lipoproteins; D002784:Cholesterol