New insights into T-cell antigen receptor structure and signal transduction.
Recent studies have provided insights into how the complex structure of the T-cell antigen receptor relates to its signal transduction function. Both the CD3 and zeta subunits contain functioning signaling modules that regulate the activation of tyrosine kinases and phosphorylation of cellular substrates.
Chan
A C
AC
Howard Hughes Medical Institute, University of California, San Francisco.
Irving
B A
BA
Weiss
A
A
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008969:Molecular Sequence Data; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D017260:Receptor-CD3 Complex, Antigen, T-Cell / Q000737:chemistry; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013329:Structure-Activity Relationship
D017260:Receptor-CD3 Complex, Antigen, T-Cell; D011948:Receptors, Antigen, T-Cell; D011505:Protein-Tyrosine Kinases