title: [Organic correlates of depressive symptoms in Alzheimer's dementia. Results of a prospective study, review of the literature].
abstract: The diagnosis of Alzheimer's disease (AD) was verified at post-mortem examination in 46 patients (9 male: 37 female; mean age 83.6 +/- 6.5 years) from a prospective clinical study. Compared to 10 age-matched controls, the total AD group showed a significant neuronal loss in the locus coeruleus, dorsal raphe nucleus, substantia nigra and in the basal nucleus of Meynert. Twelve patients (1 male: 11 female) had experienced symptoms of depression. These patients had significantly lower neuronal counts in the locus coeruleus, but less severe cell loss in the basal nucleus of Meynert compared to the AD patients without depression.
authors.affiliation: Section of Old Age Psychiatry, Institute of Psychiatry, London, UK.
authors.forename: H
authors.initials: H
authors.lastname: Förstl
authors.forename: A
authors.initials: A
authors.lastname: Burns
authors.forename: N
authors.initials: N
authors.lastname: Cairns
authors.forename: P
authors.initials: P
authors.lastname: Luthert
authors.forename: P
authors.initials: P
authors.lastname: Lantos
authors.forename: R
authors.initials: R
authors.lastname: Levy
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000473:pathology / Q000523:psychology; D001921:Brain / Q000473:pathology; D001925:Brain Damage, Chronic / Q000175:diagnosis* / Q000473:pathology / Q000523:psychology; D003866:Depressive Disorder / Q000175:diagnosis* / Q000473:pathology / Q000523:psychology; D005260:Female; D006801:Humans; D008125:Locus Coeruleus / Q000473:pathology; D008297:Male; D019965:Neurocognitive Disorders / Q000175:diagnosis* / Q000473:pathology / Q000523:psychology; D016874:Neurofibrillary Tangles / Q000473:pathology; D009474:Neurons / Q000473:pathology; D011446:Prospective Studies
vernacular_title: Organische Grundlagen depressiver Symptome bei der Alzheimer Demenz. Ergebnisse einer prospektiven Untersuchung, Literaturübersicht.