[Antibiotic therapy in acute diffuse peritonitis].
The pharmacokinetics and clinical efficacy of antibiotics administered by various routes in acute diffuse peritonitis were studied on 25 non-inbred dogs and potential of lymphotropic administration of the antibiotics through the mesentery of the small intestine in urgent surgical operations because of the diseases of the abdominal cavity was estimated. It was shown that the intra-mesenteric administration of the antibiotics was more efficient. In acute diffuse peritonitis it provided high therapeutic concentrations of gentamicin in the central lymph and lymph nodes of the abdominal cavity.
Egamov
Iu S
IuS
D000208:Acute Disease; D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D005839:Gentamicins / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D007273:Injections, Intramuscular; D007274:Injections, Intraperitoneal; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism; D008198:Lymph Nodes / Q000187:drug effects / Q000378:metabolism; D008643:Mesentery / Q000187:drug effects / Q000378:metabolism; D010538:Peritonitis / Q000188:drug therapy* / Q000378:metabolism
D005839:Gentamicins
Antibiotikoterapiia pri ostrom razlitom peritonite.