Primary, single, autosomal trisomies associated with haematological disorders. United Kingdom Cancer Cytogenetics Group (UKCCG).
The United Kingdom Cancer Cytogenetics Group (UKCCG) collected retrospective data on 73 cases of acquired, single autosomal trisomies associated with haematological disorders, excluding trisomy 8 cases in myeloid conditions and trisomy 12 in lymphoid conditions. The bone marrow and/or blood smear morphology was reviewed in 49 cases. Trisomies for chromosomes 21, 11, 9 and 13 respectively were represented most frequently. Trisomy was not reported for chromosomes 1, 2, 5, 7, 16 or 17 and there was only one case of trisomy 8 in a non-myeloid condition and one case of trisomy 18. Of the 73 patients, 60 had myeloid disorders, 12 had lymphoid disorders and there was one case of acute undifferentiated leukaemia. There was no evidence of predisposing factors involved in the etiology of trisomy associated with haematological disorders.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000753:Anemia, Refractory / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics*; D007943:Leukemia, Hairy Cell / Q000235:genetics; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics; D007951:Leukemia, Myeloid / Q000235:genetics; D015477:Leukemia, Myelomonocytic, Chronic / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011087:Polycythemia Vera / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics; D012189:Retrospective Studies; D014314:Trisomy; D006113:United Kingdom