[Studies on the alkaloids of Cephalotaxus. VII. Structures and semi-synthesis of two anticancer cephalotaxine esters].
Two new alkaloids, namely neoharringtonine (1) and anhydroharringtonine (2) with significant antileukemic activity were isolated from Cephalotaxus fortunei Hook f.. Their structures have been established by spectral analyses and semi-synthesis. Seven known alkaloids, deoxyharringtonine (3), isoharringtonine (4), isocephalotaxinone (5), acetylcephalotaxine (6), cephalotaxine (7), harringtonine (8) and homoharringtonine (9), were also isolated and identified.
Wang
D Z
DZ
Shanghai Institute of Materia Medica, Academia Sinica.
Ma
G E
GE
Xu
R S
RS
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D006248:Harringtonines / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D006248:Harringtonines; C062500:harringtonin