In vitro susceptibilities of Borrelia burgdorferi to five oral cephalosporins and ceftriaxone.
We determined the in vitro susceptibilities of eight Borrelia burgdorferi isolates to five oral cephalosporins. MICs for B. burgdorferi 297 were 23 micrograms/ml (cephalexin), 45 micrograms/ml (cefadroxil), 91 micrograms/ml (cefaclor), 0.13 microgram/ml (cefuroxime), 0.8 microgram/ml (cefixime), and 0.02 microgram/ml (ceftriaxone). When B. burgdorferi isolates were exposed to concentrations twice the MIC of cefuroxime, cefixime, or ceftriaxone, at least 72 h of incubation was required to kill 99% of the organisms.
Agger
W A
WA
Microbiology Research Laboratory, Gundersen Medical Foundation, Las Crosse, Wisconsin 54601.
Callister
S M
SM
Jobe
D A
DA
D015748:Borrelia burgdorferi Group / Q000187:drug effects*; D002443:Ceftriaxone / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D006207:Half-Life; D006801:Humans; D008193:Lyme Disease / Q000382:microbiology
D002511:Cephalosporins; D002443:Ceftriaxone