title: Effect of Norplant-2 rods on haemostatic function.
abstract: A longitudinal study on one-hundred Singaporean women using Norplant-2 rod implant for contraception and their effects on the haemostatic function was carried out. There was a decrease in vitamin K-dependent Factors II, VII and a tendency towards lowered fibrinolytic activity after prolong use of Norplant-2 rods. The results indicate that the Norplant-2 rod implant system does not contribute towards hypercoagulable state but increased platelets and accelerated platelet aggregation observed will require further study to ascertain whether there is a concomitant increase in platelet activation.
authors.affiliation: Department of Obstetrics and Gynaecology, National University Hospital, Singapore.
authors.forename: S
authors.initials: S
authors.lastname: Kuldip
authors.forename: O A
authors.initials: OA
authors.lastname: Viegas
authors.forename: S L
authors.initials: SL
authors.lastname: Koh
authors.forename: S S
authors.initials: SS
authors.lastname: Ratnam
mesh_terms: D001779:Blood Coagulation Factors / Q000032:analysis / Q000037:antagonists & inhibitors; D004343:Drug Implants; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D016912:Levonorgestrel / Q000494:pharmacology*; D008137:Longitudinal Studies; D010314:Partial Thromboplastin Time; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count / Q000187:drug effects; D011517:Prothrombin Time
chemical_list: D001779:Blood Coagulation Factors; D004343:Drug Implants; D006454:Hemoglobins; D016912:Levonorgestrel