The effect of heparegen on antioxidant enzyme activities in ethanol-induced liver injury in rats.
SOD, CAT, GSH-Px, and sulfhydryl compounds MDA contents in liver of rats treated with heparegen for 7, 14, and 21 days after alcoholic liver injury have been investigated. After use of this drug, we found beneficial effects on GSH-Px activity, sulfhydryl compounds (total and nonprotein), and MDA content and a partially beneficial effect on SOD and CAT activities. These enzyme activities after 21 days of drug administration were restored. Furthermore, heparegen shortens the time necessary for the return of AIAT and GGTP to normal value. This enzymatic data are supported by histological studies in light microscopy.
Farbiszewski
R
R
Department of Inorganic and Analytical Chemistry, Medical Academy, Bialystok, Poland.
Radecka
A
A
Chwiecko
M
M
Holownia
A
A
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002374:Catalase / Q000032:analysis*; D000431:Ethanol / Q000633:toxicity*; D005979:Glutathione Peroxidase / Q000032:analysis*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D013438:Sulfhydryl Compounds / Q000032:analysis; D013482:Superoxide Dismutase / Q000032:analysis*; D013844:Thiazoles / Q000494:pharmacology*; D053778:Thiazolidines
D000975:Antioxidants; D013438:Sulfhydryl Compounds; D013844:Thiazoles; D053778:Thiazolidines; D000431:Ethanol; D008315:Malondialdehyde; C003438:thiazolidine-4-carboxylic acid; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase