title: Physiologic studies of tracheobronchial stents in airway obstruction.
abstract: When airway obstruction is due to extraluminal compression and/or dynamic collapse, metal and silicone rubber prosthetic stents may stabilize the affected airway. Through a rigid bronchoscope, we inserted three metal stents in two patients and 18 silicone stents in 15 adult patients with symptomatic tracheobronchial compression and dynamic airway collapse. The underlying cause was malignancy in three patients; benign tracheobronchial malacia in three patients, two of whom refused surgical resection; and tracheobronchial stenosis that developed at the anastomotic site following lung transplantation in 11 patients. Clinical status and lung function studies were analyzed before and after stent insertion. Following stent insertion, airway diameter at least doubled and near normal patency of the affected tracheobronchial tree was achieved in every patient using stents of axial length 4 to 5 cm. The stents were well tolerated clinically, and all patients noted immediate relief of dyspnea. Following stent insertion, the forced vital capacity (FVC) increased from 64 +/- 21% predicted (mean +/- 1 SD) to 73 +/- 19% predicted, p less than 0.1; the forced expiratory volume in 1 s (FEV1) from 49 +/- 25% predicted to 72 +/- 26% predicted, p less than 0.02; the ratio of the FEV1/FVC from 59 +/- 16% to 78 +/- 15%, p less than 0.01; and the maximum flow at 50% expired FVC from 38 +/- 26% predicted to 72 +/- 31% predicted, p less than 0.01.
authors.affiliation: Department of Medicine, Lakewood Medical Center, CA.
authors.forename: A F
authors.initials: AF
authors.lastname: Gelb
authors.forename: N
authors.initials: N
authors.lastname: Zamel
authors.forename: A
authors.initials: A
authors.lastname: Colchen
authors.forename: D P
authors.initials: DP
authors.lastname: Tashkin
authors.forename: J R
authors.initials: JR
authors.lastname: Maurer
authors.forename: G A
authors.initials: GA
authors.lastname: Patterson
authors.forename: J D
authors.initials: JD
authors.lastname: Epstein
mesh_terms: D000328:Adult; D000368:Aged; D001982:Bronchial Diseases / Q000209:etiology / Q000628:therapy*; D003251:Constriction, Pathologic / Q000209:etiology / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012129:Respiratory Function Tests; D012826:Silicone Elastomers; D015607:Stents; D014135:Tracheal Stenosis / Q000209:etiology / Q000628:therapy*
chemical_list: D012826:Silicone Elastomers