Correlation of antibodies to ribosomal P protein with psychosis in patients with systemic lupus erythematosus.
Ninety one Japanese patients with systemic lupus erythematosus (SLE) were studied to determine the clinical significance of antibodies to ribosomal P protein (anti-P). Anti-P was detected by western blotting in 38 of 91 patients (42%). Clinical symptoms of SLE were compared between patients with and without anti-P. The occurrence of lupus psychosis was significantly higher in patients with anti-P than in those without anti-P (9/38 v 1/53). No significant association was found between anti-P and other symptoms of SLE. These data strongly support the suggestion proposed by previous workers that anti-P is a marker autoantibody for the development of lupus psychosis.
Nojima
Y
Y
Third Department of Internal Medicine, Faculty of Medicine, Tokyo University, Japan.
Minota
S
S
Yamada
A
A
Takaku
F
F
Aotsuka
S
S
Yokohari
R
R
D001323:Autoantibodies / Q000032:analysis*; D015153:Blotting, Western; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000523:psychology; D008297:Male; D015800:Protozoan Proteins; D011618:Psychotic Disorders / Q000276:immunology*; D012269:Ribosomal Proteins / Q000276:immunology*
D001323:Autoantibodies; C064601:L12E protein, Trypanosoma cruzi; D015800:Protozoan Proteins; D012269:Ribosomal Proteins