The role of lipoproteins in the inactivation of endotoxin by serum.
The lipopolysaccharide (LPS)-induced release of cytokines from human monocytes can be prevented by previous interaction of serum with LPS. This inactivation is a function of lipoproteins. Here we show that LPS can be inactivated by low-density lipoproteins (LDL) as well as by high-density lipoproteins (HDL). The effects of heparin and EDTA on LPS inactivation by serum are also described.
Northoff
H
H
DRK-Blutspendezentrale, Ulm, FRG.
Flegel
W A
WA
Yurttas
R
R
Weinstock
C
C
D001427:Bacterial Toxins / Q000276:immunology*; D004305:Dose-Response Relationship, Drug; D004492:Edetic Acid / Q000494:pharmacology*; D004731:Endotoxins; D004768:Enterotoxins / Q000276:immunology*; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D008070:Lipopolysaccharides / Q000276:immunology*; D008074:Lipoproteins / Q000494:pharmacology*; D008075:Lipoproteins, HDL / Q000494:pharmacology; D008077:Lipoproteins, LDL / Q000494:pharmacology; D008079:Lipoproteins, VLDL / Q000494:pharmacology; D009000:Monocytes / Q000187:drug effects* / Q000276:immunology; D015846:Monokines / Q000502:physiology*
D001427:Bacterial Toxins; D004731:Endotoxins; D004768:Enterotoxins; D008070:Lipopolysaccharides; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D015846:Monokines; C027952:salmonella toxin; D006493:Heparin; D004492:Edetic Acid