title: Oxidative decarboxylation of naproxen.
abstract: The decarboxylation of naproxen (1H) and its salt (1-) was achieved by means of chemical [Ce(IV) or S2O8(2-)] and electrochemical oxidation. The product patterns were compatible with mechanisms involving single-electron transfer from the pi-system or the carboxylate moiety. The results are discussed in connection with the involvement of electron-transfer processes in the reported phototoxicity of naproxen.
authors.affiliation: Departamento de Química, Universidad Politécnica de Valencia, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Boscá
authors.forename: R
authors.initials: R
authors.lastname: Martínez-Máñez
authors.forename: M A
authors.initials: MA
authors.lastname: Miranda
authors.forename: J
authors.initials: J
authors.lastname: Primo
authors.forename: J
authors.initials: J
authors.lastname: Soto
authors.forename: L
authors.initials: L
authors.lastname: Vañó
mesh_terms: D004563:Electrochemistry / Q000379:methods; D009288:Naproxen / Q000737:chemistry*; D016877:Oxidants / Q000737:chemistry; D010084:Oxidation-Reduction; D012997:Solvents / Q000737:chemistry
chemical_list: D016877:Oxidants; D012997:Solvents; D009288:Naproxen