title: Comparison of salivary miconazole concentrations after administration of a bioadhesive slow-release buccal tablet and an oral gel.
abstract: The salivary miconazole concentrations after administration of a bioadhesive slow-release buccal tablet and an oral gel have been compared. The bioadhesive tablet consisted of a mixture of thermally modified starch and 5% polyacrylic acid. Although the amount of drug administered via the bioadhesive tablet was sixfold lower than when the gel was used, the salivary miconazole levels were higher and remained above the MIC value of Candida albicans for more than 10 hours. The mean adhesion time of the tablet was 586 min. The bioadhesive tablet appears to be a promising drug delivery system for the buccal administration of drugs for local therapy.
authors.affiliation: Laboratory of Pharmaceutical Technology, University of Gent, Belgium.
authors.forename: S
authors.initials: S
authors.lastname: Bouckaert
authors.forename: H
authors.initials: H
authors.lastname: Schautteet
authors.forename: R A
authors.initials: RA
authors.lastname: Lefebvre
authors.forename: J P
authors.initials: JP
authors.lastname: Remon
authors.forename: R
authors.initials: R
authors.lastname: van Clooster
mesh_terms: D000278:Administration, Buccal; D000328:Adult; D002176:Candida albicans / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D008825:Miconazole / Q000008:administration & dosage* / Q000032:analysis; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012463:Saliva / Q000737:chemistry*; D013607:Tablets
chemical_list: D003692:Delayed-Action Preparations; D005782:Gels; D013607:Tablets; D008825:Miconazole