[Leishmaniasis with multiple cutaneous nodules].
Six weeks after a holiday trip to Yugoslavia, a previously well 48-year-old man developed a reddish-livid, firm nodule, 0.5 cm in diameter, on the proximal joint of the right thumb. A similar nodule appeared nearby, as well as over the left patella. Eleven additional nodules occurred over the next 4 months. His general health remained good and physical examination merely noted the liver edge palpable 3 cm below the costal margin. The histology of one of the nodules showed a tuberculoid, plasma-rich inflammatory reaction reminiscent of leishmaniasis or brucellosis. No organisms were seen. Immunohistochemistry of a frozen section demonstrated Leishmania-associated antigens, and the Western-blot test was characteristic for leishmaniasis. No systemic treatment was undertaken because of likely alcoholic toxic liver damage. On local treatment with paromomycin-containing ointment the cutaneous nodules healed without scar within 3 months.
Stosiek
N
N
Dermatologische Universitätsklinik, Universität Erlangen.
Bogdan
C
C
Solbach
W
W
Hornstein
O P
OP
D000818:Animals; D000953:Antigens, Protozoan / Q000032:analysis; D015153:Blotting, Western; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D007891:Leishmania / Q000276:immunology; D016773:Leishmaniasis, Cutaneous / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009824:Ointments; D010303:Paromomycin / Q000008:administration & dosage
D000953:Antigens, Protozoan; D009824:Ointments; D010303:Paromomycin
Leishmaniose mit multiplen Hautherden.