title: Lymphocutaneous Nocardia brasiliensis infection acquired from a cat scratch: case report and review.
abstract: Nocardia brasiliensis is a bacterium that is most commonly found in the soil. Traumatic inoculation of N. brasiliensis into the skin is the most typical mode of acquisition of infection due to this organism. To the best of my knowledge, I report the first case of lymphocutaneous N. brasiliensis disease from a penetrating cat scratch of the skin, thereby establishing cats as vehicles for the transmission of this infection. Treatment with penicillin produced a rapid resolution of all signs and symptoms of infection. The efficacy of penicillin against the N. brasiliensis isolate recovered from this patient was highly unusual. In general, penicillin has limited therapeutic value since these organisms elaborate beta-lactamase. Sulfonamides remain the drugs of choice for the treatment of these infections. These soil-borne organisms are most likely carried on the claws of cats and may establish infection after percutaneous inoculation. A high index of suspicion for N. brasiliensis soft-tissue infection is required since a delayed or missed diagnosis may be associated with progressive local disease and/or widespread disseminated infection.
authors.affiliation: Division of Infectious Diseases, Jefferson Medical College, Philadelphia, Pennsylvania.
authors.forename: M K
authors.initials: MK
authors.lastname: Sachs
mesh_terms: D000328:Adult; D000818:Animals; D002415:Cats / Q000382:microbiology*; D004199:Disease Vectors; D005260:Female; D006801:Humans; D008199:Lymphadenitis / Q000188:drug therapy / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D009615:Nocardia / Q000187:drug effects / Q000302:isolation & purification*; D009617:Nocardia Infections / Q000188:drug therapy / Q000635:transmission*; D010406:Penicillins / Q000627:therapeutic use; D017192:Skin Diseases, Bacterial / Q000188:drug therapy / Q000635:transmission*; D014946:Wound Infection / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D010406:Penicillins