title: The effect of adding Br or Zn supplements to the dialysate on the concentrations of Br and Zn in the blood of hemodialysed patients.
abstract: The effect of adding Br or Zn supplementation to the dialysate on the concentrations of Br and Zn in the blood of hemodialysed patients, is investigated. Patients with end-stage renal failure on hemodialysis show an abnormal trace element pattern. Our patients showed lowered serum Br and Zn concentrations. Four patients were subjected to dialysates with varying Br content. The impact on their serum and packed cells concentrations was evaluated. The supplementation resulted in an increase in the concentrations in serum and in packed cells. The Br concentration in serum and packed cells closely followed the dialysate content. In order to restore the Zn concentration to the normal level a ZnCl2 solution was added to the dialysate of 4 other patients. Zn accumulated in the patient as a consequence of its diffusion against the concentration gradient.
authors.affiliation: Laboratory for Analytical Chemistry, Rijksuniversiteit Gent, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: Van Renterghem
authors.forename: R
authors.initials: R
authors.lastname: Cornelis
authors.forename: L
authors.initials: L
authors.lastname: Mees
authors.forename: R
authors.initials: R
authors.lastname: Vanholder
mesh_terms: D001966:Bromine / Q000097:blood / Q000494:pharmacology*; D015314:Dialysis Solutions / Q000737:chemistry / Q000494:pharmacology*; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000628:therapy; D008297:Male; D006435:Renal Dialysis; D015032:Zinc / Q000097:blood / Q000494:pharmacology*
chemical_list: D015314:Dialysis Solutions; D015032:Zinc; D001966:Bromine