Androgen hydroxysteroid dehydrogenases under the influence of pyridoxine derivatives.
The metabolism of testosterone in the rat ventral prostate, anterior pituitary, basal hypothalamus and amygdala was studied in vitro under the influence of vitamin B6 compounds. The influence of these compounds on the activity of 5 alpha-reductase (5 alpha-R), 3 alpha- and 17 beta-hydroxysteroid dehydrogenase (3 alpha-HSD, 17 beta-HSD) was determined for all the examined tissues. Pyridoxine hydrochloride significantly increased the activity of 5 alpha-R, 3 alpha- and 17 beta-HSD, but pyridoxal hydrochloride had an inhibitory influence on 5 alpha-R and showed no effect on 3 alpha-HSD activity at the prostate level. Male rat anterior pituitary, basal hypothalamus or amygdala incubated with pyridoxal phosphate and pyridoxal hydrochloride showed modified enzymatic activities. Pyridoxal hydrochloride showed an inhibitory effect on 5 alpha-R in the rat pituitary and basal hypothalamus as well as in the rat prostate.
Kniewald
Z
Z
Faculty of Food Technology and Biotechnology, University of Zagreb, Croatia.
Zechner
V
V
Kniewald
J
J
D015067:17-Hydroxysteroid Dehydrogenases / Q000032:analysis / Q000378:metabolism; D015096:3-Hydroxysteroid Dehydrogenases / Q000032:analysis / Q000378:metabolism; D000679:Amygdala / Q000201:enzymology / Q000378:metabolism; D000818:Animals; D006913:Hydroxysteroid Dehydrogenases / Q000032:analysis* / Q000378:metabolism / Q000502:physiology; D007031:Hypothalamus / Q000201:enzymology / Q000378:metabolism; D008297:Male; D010903:Pituitary Gland, Anterior / Q000201:enzymology / Q000378:metabolism; D011467:Prostate / Q000201:enzymology / Q000378:metabolism; D011732:Pyridoxal Phosphate / Q000494:pharmacology; D011736:Pyridoxine / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D013739:Testosterone / Q000378:metabolism
D013739:Testosterone; D011732:Pyridoxal Phosphate; D015067:17-Hydroxysteroid Dehydrogenases; D015096:3-Hydroxysteroid Dehydrogenases; D006913:Hydroxysteroid Dehydrogenases; D011736:Pyridoxine