title: In vitro percutaneous absorption of thiamine disulfide from a mixture of propylene glycol and fatty acid.
abstract: The in vitro percutaneous transport of thiamine disulfide (TDS), an oxidized dimer of thiamine, from propylene glycol through excised abdominal rat skin was studied. The application of saturated, long-chain fatty acids [stearic acid (18:0), myristic acid (14:0), and lauric acid (12:0)] as enhancers to the system was also studied. TDS permeated through rat skin from propylene glycol with a flux of 2.5 +/- 0.8 micrograms/cm2/min. The flux was enhanced 31 times by 12:0 and 1.4 times by 14:0 and was suppressed to 80% of its original value by 18:0. The absorption of TDS could not be explained by TDS permeating across a dialysis membrane, but the interaction between TDS and fatty acids may influence the system. The results show the possibility of developing a transdermal thiamine delivery system.
authors.affiliation: Kyoritsu College of Pharmacy, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Komata
authors.forename: M
authors.initials: M
authors.lastname: Inaoka
authors.forename: A
authors.initials: A
authors.lastname: Kaneko
authors.forename: T
authors.initials: T
authors.lastname: Fujie
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D005227:Fatty Acids / Q000494:pharmacology*; D066298:In Vitro Techniques; D007850:Lauric Acids / Q000494:pharmacology; D008297:Male; D008566:Membranes / Q000378:metabolism; D019814:Myristic Acid; D009227:Myristic Acids / Q000494:pharmacology; D019946:Propylene Glycol; D011409:Propylene Glycols / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012869:Skin Absorption / Q000187:drug effects*; D012995:Solubility; D013229:Stearic Acids / Q000494:pharmacology; D013831:Thiamine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
chemical_list: D005227:Fatty Acids; D007850:Lauric Acids; D009227:Myristic Acids; D011409:Propylene Glycols; D013229:Stearic Acids; D019814:Myristic Acid; C030358:lauric acid; C031183:stearic acid; D019946:Propylene Glycol; C013293:thiamine disulfide; D013831:Thiamine