title: The gene for tissue inhibitor of metalloproteinases-2 is localized on human chromosome arm 17q25.
abstract: Tissue inhibitor of metalloproteinases-2 (TIMP2) is a natural inhibitor of several proteinases that are involved in the degradation of the extracellular matrix. By means of somatic cell hybrids segregating human chromosomes, the gene encoding this inhibitor was assigned to human chromosome 17. Fluorescence in situ hybridization confirmed this assignment and allowed mapping of the gene to the terminal region (17q25) of the chromosome.
authors.affiliation: Department of Pediatrics, Childrens Hospital of Los Angeles, California.
authors.forename: Y
authors.initials: Y
authors.lastname: De Clerck
authors.forename: C
authors.initials: C
authors.lastname: Szpirer
authors.forename: M S
authors.initials: MS
authors.lastname: Aly
authors.forename: J J
authors.initials: JJ
authors.lastname: Cassiman
authors.forename: Y
authors.initials: Y
authors.lastname: Eeckhout
authors.forename: G
authors.initials: G
authors.lastname: Rousseau
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D051379:Mice; D009363:Neoplasm Proteins / Q000235:genetics*; D051381:Rats; D019716:Tissue Inhibitor of Metalloproteinase-2
chemical_list: D009363:Neoplasm Proteins; D019716:Tissue Inhibitor of Metalloproteinase-2; D008666:Metalloendopeptidases