title: Ascorbic acid status in uremics.
abstract: Plasma levels of ascorbic acid (AA) and dehydroascorbic acid (DHA) were estimated in 27 patients of end stage renal failure (ESRF) on standard conservative therapy (group A) and 9 patients of ESRF on maintenance haemodialysis (MHD; group B). Fourteen healthy subjects matched for age and sex served as control (group C). The dietary intake of vitamin C was significantly decreased in group A than in group B compared to control. Similarly, plasma AA was significantly lowered to 0.801 +/- 0.283 mg per cent in group A compared to 1.421 +/- 0.47 mg per cent in control. While it was just lowered to 1.058 +/- 0.272 mg per cent in group B. Although plasma level of DHA was raised to 0.243 +/- 0.486 mg per cent and 0.166 +/- 0.54 mg per cent in groups A and B respectively, the increase was not statistically significant. In our present study, the DHA/AA ratio was found to be inversely proportional to the plasma AA. Further, this ratio has been claimed to be a better indicator of overall reducing atmosphere (i.e., profile of vitamin C) of the body.
authors.affiliation: Division of Nephrology, Banaras Hindu University, Varanasi.
authors.forename: R G
authors.initials: RG
authors.lastname: Singh
authors.forename: A K
authors.initials: AK
authors.lastname: Gupta
authors.forename: S S
authors.initials: SS
authors.lastname: Dubey
authors.lastname: Usha
authors.forename: M R
authors.initials: MR
authors.lastname: Sharma
mesh_terms: D001205:Ascorbic Acid / Q000008:administration & dosage / Q000097:blood*; D001206:Ascorbic Acid Deficiency; D003683:Dehydroascorbic Acid / Q000097:blood*; D004435:Eating; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D014511:Uremia / Q000097:blood*
chemical_list: D001205:Ascorbic Acid; D003683:Dehydroascorbic Acid