No correlation between site of breakpoint in the BCR gene and platelet counts in Philadelphia chromosome-positive CML.
In chronic myelogenous leukemia (CML) malignant cells are characterised by the Philadelphia chromosome (Ph), resulting from a translocation t(9;22). The position of the breakpoint within the major breakpoint cluster region (M-bcr) on chromosome 22 has been shown to correlate with the clinical course of the disease or, more recently, thrombopoietic activity. We have therefore determined the breakpoint localisation in 53 Ph-positive CML patients. Following the 5'/3'-region definition of Inokuchi et al. Leukemia Research 15, 1067 (1991) [1], 22 of our patients have 5' and 31 of our patients have 3' orientated breaks. No correlation was found between platelet counts and breakpoint localisation.
Opalka
B
B
Department of Internal Medicine, West German Cancer Centre Essen, University of Essen Medical School.
Wandl
U B
UB
Kloke
O
O
Beer
U
U
Seeber
S
S
Niederle
N
N
D002869:Chromosome Aberrations / Q000235:genetics*; D002892:Chromosomes, Human, Pair 22; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood / Q000235:genetics* / Q000628:therapy; D010976:Platelet Count; D011379:Prognosis