title: Zidovudine-induced blockade of the expression and function of the erythropoietin receptor.
abstract: Treatment of bone marrow progenitor cells (BMPC) with zidovudine (AZT) at various concentrations (0.5 to 20 microM) in vitro for 24 hr caused a concentration-dependent decrease in erythropoietin (Epo) receptor expression. The decrease in Epo receptors correlated with a decline in mRNA levels of the receptor. These results suggest that AZT-induced down-regulation of Epo receptor expression followed by loss of Epo-receptor mediated signal transduction is a significant contributory factor to AZT-induced erythroid toxicity.
authors.affiliation: Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA 70112.
authors.forename: S R
authors.initials: SR
authors.lastname: Gogu
authors.forename: J S
authors.initials: JS
authors.lastname: Malter
authors.forename: K C
authors.initials: KC
authors.lastname: Agrawal
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D003114:Colony-Forming Units Assay; D016049:Didanosine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D015536:Down-Regulation; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D012333:RNA, Messenger / Q000378:metabolism; D017467:Receptors, Erythropoietin / Q000037:antagonists & inhibitors / Q000187:drug effects* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D015215:Zidovudine / Q000494:pharmacology*
chemical_list: D012333:RNA, Messenger; D017467:Receptors, Erythropoietin; D015215:Zidovudine; D016049:Didanosine