The influence of fenarimol on DNA synthesis and mitotic activity in rat liver.
Fenarimol administered in one single oral dose of 125 or 62.5 mg kg-1 body wt. day-1, respectively, stimulated rat liver enlargement at a dose-independent rate. Three single doses of fenarimol produced dose-dependent liver growth, whereas five single doses caused no further increase in liver weight. This increase was accompanied by an increase in hepatic DNA synthesis and mitotic activity, with a peak on the first day after the beginning of the experiments. The increase in binuclear hepatocytes and signs of necrosis suggested that the hepatomitogenic effect reflected a compensatory hyperplasia. After both three and five single doses the hepatomitogenic effect was suppressed, as a result of tolerance development.
Palut
D
D
Department of Environmental Toxicology, National Institute of Hygiene, Warsaw, Poland.
Ludwicki
J
J
Szlezak-Kopeć
J
J
D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D005659:Fungicides, Industrial / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008938:Mitosis / Q000187:drug effects*; D009929:Organ Size / Q000187:drug effects; D011743:Pyrimidines / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
D005659:Fungicides, Industrial; D011743:Pyrimidines; D004247:DNA; C033789:fenarimol