title: Vasoconstrictor activity of 8-O-acetylharpagide from Ajuga reptans.
abstract: The traditional therapeutic indications for the use of Ajuga reptans (Labiatae) have been investigated. The H2O-soluble part of a crude and partially purified MeOH extract and two isolated iridoids (8-O-acetylharpagide and harpagide), were tested for a biological activity on isolated smooth muscle preparations from guinea pig.
authors.affiliation: Istituto Policattedra di Discipline Biologiche, Facoltà di Farmacia, Università di Pisa, Italy.
authors.forename: M C
authors.initials: MC
authors.lastname: Breschi
authors.forename: E
authors.initials: E
authors.lastname: Martinotti
authors.forename: S
authors.initials: S
authors.lastname: Catalano
authors.forename: G
authors.initials: G
authors.lastname: Flamini
authors.forename: I
authors.initials: I
authors.lastname: Morelli
authors.forename: A M
authors.initials: AM
authors.lastname: Pagni
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D003106:Colon / Q000187:drug effects; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D010936:Plant Extracts / Q000032:analysis; D010946:Plants, Medicinal / Q000737:chemistry*; D011714:Pyrans / Q000737:chemistry / Q000494:pharmacology*; D014662:Vasoconstrictor Agents / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts; D011714:Pyrans; D014662:Vasoconstrictor Agents; C077626:8-O-acetylharpagide