Association of methotrexate, rheumatoid arthritis and lymphoma: report of 2 cases and literature review.
We describe 2 Caucasian men with rheumatoid arthritis (RA) who developed non-Hodgkin's lymphoma of identical histological type during treatment with low dose oral weekly methotrexate (MTX). Both patients had longstanding RA and had been treated with MTX for over 2 years at time of tumor diagnosis; neither had secondary Sjögren's syndrome. The oncogenic potential of MTX and RA arthritis is reviewed.
Kingsmore
S F
SF
Department of Medicine, Duke University Medical Center, Durham, NC 27710.
Hall
B D
BD
Allen
N B
NB
Rice
J R
JR
Caldwell
D S
DS
D000284:Administration, Oral; D000328:Adult; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000139:chemically induced; D016403:Lymphoma, Large B-Cell, Diffuse / Q000139:chemically induced; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D008875:Middle Aged; D010641:Phenotype
D008727:Methotrexate