New antiviral antibiotics, cycloviracins B1 and B2. II. Structure determination.
The structures of novel antiviral antibiotics, cycloviracins B1 and B2 have been determined by means of chemical and spectroscopic methods including 2D NMR correlation spectroscopy. The antibiotics are unique macrocyclic diesters consisting of two D-glucoses, three 2-O-methyl-D-glucoses and two (C24 and C26) hydroxy fatty acids.
Tsunakawa
M
M
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
Kotake
C
C
Yamasaki
T
T
Moriyama
T
T
Konishi
M
M
Oki
T
T
D000192:Actinomycetales / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification; D006868:Hydrolysis; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D018942:Macrolides; C077636:cycloviracin B1; C077637:cycloviracin B2