title: 6-Gingesulfonic acid, a new anti-ulcer principle, and gingerglycolipids A, B, and C, three new monoacyldigalactosylglycerols, from zingiberis rhizoma originating in Taiwan.
abstract: By monitoring the effects on HCl/ethanol-induced gastric lesions in rats, a new antiulcer principle named 6-gingesulfonic acid was isolated from Zingiberis Rhizoma, the dried rhizome of Zingiber officinale Roscoe (cultivated and processed in Taiwan) together with three new monoacyldigalactosylglycerols named gingerglycolipids A, B and C. Their chemical structures were elucidated on the basis of chemical and physicochemical evidence. 6-Gingesulfonic acid showed more potent anti-ulcer activity than 6-gingerol and 6-shogaol.
authors.affiliation: Kyoto Pharmaceutical University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: S
authors.initials: S
authors.lastname: Hatakeyama
authors.forename: K
authors.initials: K
authors.lastname: Taniguchi
authors.forename: H
authors.initials: H
authors.lastname: Matuda
authors.forename: J
authors.initials: J
authors.lastname: Yamahara
mesh_terms: D000897:Anti-Ulcer Agents / Q000302:isolation & purification* / Q000494:pharmacology; D005697:Galactosides / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D005989:Glycerides / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D013451:Sulfonic Acids / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D013624:Taiwan
chemical_list: D000897:Anti-Ulcer Agents; D005697:Galactosides; D005989:Glycerides; D013451:Sulfonic Acids; C077820:6-gingesulfonic acid; D006139:Guaiacol