Measurement of digitalis-glycoside levels in ocular tissues: a way to improve postmortem diagnosis of lethal digitalis-glycoside poisoning? I. Digoxin.
Prompted by animal studies reporting the accumulation of digitalis-glycosides in ocular tissues, we investigated whether measurement of digoxin levels in human ocular tissues can improve the postmortem diagnosis of lethal digoxin intoxication. Digoxin was measured in the vitreous humor and choroid-retina of patients who had received in-patient treatment with digoxin prior to death (therapeutic group) and in a single case of suicidal intoxication. The results were compared with the digoxin levels in the femoral vein blood, myocardium, kidney and liver, and evaluated in light of the medical history of each patient. In the therapeutic group the mean digoxin level was higher in the choroid-retina than in other tissues and body fluids. The range of variation in levels in the choroid-retina following therapeutic doses was comparable to that in the other tissues. An extremely high level of digoxin was present in the choroid-retina in the case of suicidal intoxication. In all cases, levels in the vitreous humor were very low compared to those in the choroid-retina. Hence, it is unlikely that significant distortion of choroid-retinal levels occurs due to postmortem diffusion of digoxin into the vitreous body. Our results indicate that measurement of digoxin levels in the choroid-retina can aid the postmortem diagnosis of lethal digoxin intoxication.
Ritz
S
S
Institut für Rechtsmedizin, Christian-Albrechts-Universität zu Kiel, Federal Republic of Germany.
Harding
P
P
Martz
W
W
Schütz
H W
HW
Kaatsch
H J
HJ
D000368:Aged; D000369:Aged, 80 and over; D001082:Aqueous Humor / Q000737:chemistry*; D002829:Choroid / Q000737:chemistry*; D004077:Digoxin / Q000737:chemistry* / Q000506:poisoning; D062787:Drug Overdose / Q000175:diagnosis; D005069:Evaluation Studies as Topic; D005260:Female; D005554:Forensic Medicine / Q000379:methods / Q000592:standards*; D006801:Humans; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000737:chemistry; D011041:Poisoning / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D011180:Postmortem Changes; D012160:Retina / Q000737:chemistry*
D004077:Digoxin