Clonal origin of skin and bone tumors produced by repeated beta-irradiation in mosaic cell mice.
Clonal origin of skin and bone tumors produced by repeated beta-irradiation was determined by using mice with cellular mosaicism created by random X-chromosome inactivation, on the basis of phosphoglycerate kinase-1 (PGK). The backs of female C3H/He (Pgk-1a/Pgk-1b) mice were exposed to beta rays from 90Sr-90Y at a dose of 3 Gy per exposure 3 times weekly until tumors appeared. The cumulative tumor incidence reached 100% 500 days after the beginning of irradiation, as determined by the Kaplan-Meier method. All 8 tumors examined were of a single PGK phenotype: 5 squamous cell carcinomas and 2 osteosarcomas of A-type, and 1 squamous cell carcinoma of B-type. The absence of double PGK phenotype (AB-type) tumors indicated the monoclonal origin of the tumors produced by repeated irradiation.
Ootsuyama
A
A
Radiobiology Division, National Cancer Center Research Institute, Tokyo.
Tanaka
K
K
Tanooka
H
H
D000818:Animals; D001610:Beta Particles; D001859:Bone Neoplasms / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D004303:Dosage Compensation, Genetic; D005260:Female; D051379:Mice; D008809:Mice, Inbred C3H; D009030:Mosaicism; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D012516:Osteosarcoma / Q000473:pathology*; D010735:Phosphoglycerate Kinase / Q000032:analysis; D012878:Skin Neoplasms / Q000473:pathology*; D013326:Strontium Radioisotopes; D015021:Yttrium Radioisotopes
D013326:Strontium Radioisotopes; D015021:Yttrium Radioisotopes; D010735:Phosphoglycerate Kinase