Effects of hickory-smoke condensate on development of pepsinogen 1-altered pyloric glands in rats.
Hickory-smoke condensate (HSC) is a popular food flavouring in the USA. Available data have suggested that this food additive has tumour-initiating/promoting potential. Accordingly, a commercial HSC has been investigated for its capacity to promote tumours in the rat glandular stomach using pepsinogen 1 (Pg 1)-altered pyloric glands (PAPG) as the marker of preneoplastic lesions. The development of PAPG initiated by a single intragastric administration of N-methyl-N'-nitroso-N-nitrosoguanidine was significantly increased by feeding rats a diet containing 5% HSC; no effect was observed with lower doses (1.25 or 2.5%) of HSC. The results suggest that HSC has weak tumour-promoting potential in the rat glandular stomach.
Shichino
Y
Y
First Department of Pathology, Nagoya City University Medical School, Japan.
Tatematsu
M
M
Ohshima
H
H
Bartsch
H
H
Furihata
C
C
Ito
N
N
D000818:Animals; D001284:Atrophy; D005503:Food Additives / Q000008:administration & dosage / Q000633:toxicity*; D005753:Gastric Mucosa / Q000473:pathology; D006965:Hyperplasia; D007124:Immunoenzyme Techniques; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D010435:Pepsinogens / Q000494:pharmacology*; D011706:Pyloric Antrum / Q000187:drug effects; D051381:Rats; D011921:Rats, Inbred WKY; D012906:Smoke; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000473:pathology; D014934:Wood
D005503:Food Additives; D010435:Pepsinogens; D012906:Smoke; D008769:Methylnitronitrosoguanidine