title: Increased iron content in the putamen of patients with striatonigral degeneration.
abstract: We measured the total content of iron, copper, zinc and manganese in the putamen of four patients with striatonigral degeneration (SND) and age- and gender-matched normal controls. The iron content in the SND patients was five times greater than in the controls. Electron microscopic histochemistry revealed the iron reaction products in the pigments showing a triphasic pattern of coarse, electron-dense globules, fine granular and fibrillary materials, and lamellated structures. These findings suggest that increased iron deposition may be related to pigment formation in the putamen of SND.
authors.affiliation: Bluestone Laboratory, Montefiore Medical Center, Bronx, NY 10467.
authors.forename: S
authors.initials: S
authors.lastname: Kato
authors.forename: S
authors.initials: S
authors.lastname: Meshitsuka
authors.forename: E
authors.initials: E
authors.lastname: Ohama
authors.forename: J
authors.initials: J
authors.lastname: Tanaka
authors.forename: J F
authors.initials: JF
authors.lastname: Llena
authors.forename: A
authors.initials: A
authors.lastname: Hirano
mesh_terms: D000368:Aged; D002493:Central Nervous System Diseases / Q000473:pathology*; D003342:Corpus Striatum / Q000473:pathology*; D005260:Female; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008670:Metals / Q000378:metabolism; D008854:Microscopy, Electron; D008875:Middle Aged; D011699:Putamen / Q000378:metabolism*; D013378:Substantia Nigra / Q000473:pathology*
chemical_list: D008670:Metals; D007501:Iron