Embryonic development in the chick following exposure to ethanol, acetaldehyde and cyanamide.
The influence of cyanamide, an inhibitor of aldehyde dehydrogenase, on the embryopathic effects of ethanol and acetaldehyde, was investigated in the chick embryo. Both ethanol and cyanamide significantly increased embryonic mortality, but did not affect embryonic growth, compared to treatment with either ethanol or cyanamide. Acetaldehyde combined with cyanamide increased embryonic mortality and retarded embryonic growth. Cyanamide influence on embryonic development was minimal. The extent of acetaldehyde involvement in ethanol teratogenicity remains unclear from the present findings.
Gilani
S
S
Department of Anatomy, University of Medicine and Dentistry of New Jersey, Newark.
Persaud
T V
TV
D000079:Acetaldehyde / Q000494:pharmacology*; D000818:Animals; D002642:Chick Embryo; D003484:Cyanamide / Q000494:pharmacology*; D004347:Drug Interactions; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects
D000431:Ethanol; D003484:Cyanamide; D000079:Acetaldehyde