UN-1, a murine monoclonal antibody recognizing a human thymocyte undescribed antigen.
A monoclonal antibody (MoAb), UN-1, specific for a human thymocyte cell surface antigen was produced. The same MoAb recognized in immunofluorescence also cells of the human T line HPB-ALL, while did not bind human peripheral blood cells and cells of some T, B and myeloid lines. Western blotting analysis of thymocyte membranes with MoAb UN-1 revealed a structure with a molecular weight of 150 kDa. Therefore both the pattern of expression and the size of the antigen recognized by MoAb UN-1 did not correspond to any previously described cell surface molecule.
Tassone
P
P
Dip. di Med. Sper. e Clin., Catanzaro, Italy.
Bond
H
H
Bonelli
P
P
Tuccillo
F
F
Cecco
L
L
Lamberti
A
A
De Lorenzo
F
F
Cerra
M
M
Turco
M C
MC
Venuta
S
S
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D015153:Blotting, Western; D002459:Cell Fusion; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface