Lymph flow from murine footpad tumors before and after sublethal hyperthermia.
The effect of local hyperthermia (43.5 degrees C for 1 h) on lymph flow from B16-F10 tumor-bearing foot pads of C57BL/6 mice was measured by monitoring the clearance of 99mTc-labeled human serum albumin. The foot was represented by a single-compartment model enabling a quantitative computation of lymphatic flow from the tumor to regional lymph nodes. Lymphatic flow from untreated tumors was 0.0059 +/- 0.0011 ml/min cm3 compared to 0.0118 +/- 0.0027 ml/min cm3 lymphatic flow from tumors immediately following heating. Morphological alterations in tumor blood vessels result in their high vascular permeability. The increase in lymphatic clearance from tumors after sublethal hyperthermia is compatible with the increase in interstitial fluid formation in tumors based on Starling's Law.
Avery
M
M
Department of Radiation Oncology, Henry Ford Hospital, Detroit, Michigan 48202.
Nathanson
S D
SD
Hetzel
F W
FW
D000818:Animals; D005260:Female; D005534:Foot Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy; D006979:Hyperthermia, Induced; D016013:Likelihood Functions; D008196:Lymph / Q000000981:diagnostic imaging / Q000502:physiology*; D008546:Melanoma, Experimental / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D011877:Radionuclide Imaging; D013668:Technetium Tc 99m Aggregated Albumin
D013668:Technetium Tc 99m Aggregated Albumin