[Small intestinal ulceration and stenosis induced by non-steroidal anti-inflammatory agents].
We report a case who developed a small bowel ulceration in a long segment of distal duodenum and proximal jejunum, a few days after he had taken high doses of diclofenac. After a month, it was complicated by a stenosis of the same segment. Nonsteroidal antiinflammatory drugs have recently been recognised as a possible etiologic factor of small bowel ulcerations. Clinical findings are aspecific. Complications of small bowel ulcerations are: obstruction, perforation or bleeding. Those have to be treated by surgery. We proposed a physiopathologic model and correlated it with histological findings.


CONCLUSIONS
careful prescription of those drugs has to be pursued and one should think about a small bowel ulceration in a patient with an abdominal syndrome, who takes non-steroidal antiinflammatory drugs.
Chapelle
T
T
Dienst Heelkunde, St. Vincentiusziekenhuis Antwerpen, Universitaire Instelling Antwerpen.
Reher
S
S
Devriendt
P
P
Colemont
L
L
Van Moer
E
E
Van der Stighelen
Y
Y
Eyskens
E
E
D000368:Aged; D004008:Diclofenac / Q000009:adverse effects* / Q000494:pharmacology; D004381:Duodenal Ulcer / Q000139:chemically induced*; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects; D007415:Intestinal Obstruction / Q000139:chemically induced* / Q000601:surgery; D007579:Jejunal Diseases / Q000139:chemically induced*; D008297:Male; D014456:Ulcer / Q000139:chemically induced
D004008:Diclofenac
Dundarmulceratie en -stenose geïnduceerd door niet-steroïdale anti-inflammatoire farmaca.