title: Characterization of group specific antibodies in primates: studies with SIV envelope in macaques.
abstract: Sera from SIV-infected macaques were found to contain antibodies that reacted with conformation-dependent, group-specific determinants on the SIV envelope protein gp130. These conformation-dependent antibodies exhibited virus neutralizing activity; their presence was associated with protection in vaccine studies. The properties of these antibodies are quite similar to those that have been identified in sera from HIV-infected human subjects. These data suggest that the SIV envelope gp130 remains a candidate for subunit vaccine studies.
authors.affiliation: Chiron Corporation, Emeryville, CA 94608.
authors.forename: N L
authors.initials: NL
authors.lastname: Haigwood
authors.forename: L
authors.initials: L
authors.lastname: Misher
authors.forename: S M
authors.initials: SM
authors.lastname: Chin
authors.forename: M
authors.initials: M
authors.lastname: Blair
authors.forename: V
authors.initials: V
authors.lastname: Planelles
authors.forename: C J
authors.initials: CJ
authors.lastname: Scandella
authors.forename: K S
authors.initials: KS
authors.lastname: Steimer
authors.forename: M B
authors.initials: MB
authors.lastname: Gardner
authors.forename: T
authors.initials: T
authors.lastname: Yilma
authors.forename: V M
authors.initials: VM
authors.lastname: Hirsch
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D015153:Blotting, Western; D016466:CHO Cells; D006224:Cricetinae; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D015497:HIV-1 / Q000276:immunology; D007106:Immune Sera / Q000276:immunology; D008251:Macaca; D009500:Neutralization Tests; D015531:Radioimmunoprecipitation Assay; D011994:Recombinant Proteins / Q000276:immunology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D015164:Vaccines, Inactivated / Q000276:immunology; D014759:Viral Envelope Proteins / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D007106:Immune Sera; D011994:Recombinant Proteins; D015164:Vaccines, Inactivated; D014759:Viral Envelope Proteins; D014765:Viral Vaccines