St-93 hyperglycemia in Wistar rats.
The alpha 2-adrenoceptor agonist St-93 was evaluated for its effect on blood glucose levels in Wistar rats. A dose-dependent increase in blood glucose was observed in rats after intraperitoneal administration of St-93. The hyperglycemic effect of St-93 was not altered by prazosin and propranolol, whereas idazoxan significantly inhibited this effect. Pretreatment with reserpine did not affect the hyperglycemic effect of St-93. There was no significant increase in the blood glucose values with St-93 in streptozotocin-diabetic rats. It may be concluded that the hyperglycemia induced by St-93 is mediated through alpha 2-adrenoceptors, possibly located on pancreatic beta-cells.
Thomas
G P
GP
Biology Division, I.D.P.L. Research Centre, Hyderabad, India.
Krishnamurthy
A
A
Thapar
G S
GS
Varma
R K
RK
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D003000:Clonidine / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000097:blood; D006943:Hyperglycemia / Q000097:blood / Q000139:chemically induced*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012110:Reserpine / Q000494:pharmacology
D000889:Anti-Arrhythmia Agents; D001786:Blood Glucose; C054060:St 93; D012110:Reserpine; D003000:Clonidine