[Toxic effects in rabbits after immunization against the pyrrolizidine alkaloid retrorsine].
Six rabbits were immunized against the pyrrolizidine alkaloid retrorsin, conjugated to bovine serum albumin. Seven i.v. inoculations were distributed over a period of half a year. The total antigen dose differed between animals. Towards the end of the experiment all animals (except 2 receiving the lowest antigen dose) suffered from apathy, anorexia and loss of body weight. Pathologically these symptoms correlated well with liver cirrhosis, gradually dependent on the total antigen dose. Blood-chemical parameters were disparate and contradictory.
Leidinger
E
E
Institut für Medizinische Chemie, Universität Wien.
Loupal
G
G
Gutleb
R
R
Miller
I
I
Chizzola
R
R
D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000276:immunology / Q000633:toxicity; D005260:Female; D007114:Immunization / Q000662:veterinary*; D008103:Liver Cirrhosis / Q000139:chemically induced / Q000662:veterinary*; D008297:Male; D011041:Poisoning / Q000517:prevention & control / Q000662:veterinary*; D011763:Pyrrolizidine Alkaloids / Q000276:immunology* / Q000633:toxicity; D011817:Rabbits
D000941:Antigens; D011763:Pyrrolizidine Alkaloids; C003300:retrorsine
Toxische Effekte beim Kaninchen durch Immunisierung gegen das Pyrrolizidinalkaloid Retrorsin.