A molecular recognizing system of serotonin in rat fetal axonal growth cones: uptake and high affinity binding.
Axonal growth cone particles (AGCP) isolated from prenatal and postnatal rat brain had different high-affinity 5-HT uptake characteristics. In postnatal AGCP the uptake behaves as in the adult rat brain, while in the prenatal AGCP the uptake characteristics seem to be in a transitional stage. Also in prenatal AGCP we observed specific, high-affinity 5-HT binding sites. These results support the idea of an important role for 5-HT during axogenesis.
Mercado
R
R
Department of Physiology, Biophysics and Neurosciences, Centro de Investigacion y de Estudios Avanzados del IPN, México, DF, México.
Hernández
J
J
D000818:Animals; D001369:Axons / Q000502:physiology*; D005260:Female; D005333:Fetus / Q000166:cytology*; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D007700:Kinetics; D008854:Microscopy, Electron; D011247:Pregnancy; D051381:Rats; D012701:Serotonin / Q000378:metabolism* / Q000502:physiology
D012701:Serotonin