Acute tubulo-interstitial nephritis in a dog after halothane anaesthesia and administration of flunixin meglumine and trimethoprim-sulphadiazine.
Acute tubulo-interstitial nephritis was diagnosed post mortem when a dog died four days after surgery for a femoral head resection. Possible causative factors associated with halothane anaesthesia, flunixin meglumine analgesia and prophylactic antibiotic therapy with trimethoprim-sulphadiazine are discussed. It is concluded that death was due to renal failure associated with tubulo-interstitial nephritis as a result of a combination of ischaemic and toxic events.
McNeil
P E
PE
Department of Veterinary Pathology, University of Glasgow Veterinary School, Bearsden.
D000769:Anesthesia, Inhalation / Q000662:veterinary; D000818:Animals; D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects; D003002:Clonixin / Q000009:adverse effects / Q000031:analogs & derivatives*; D004283:Dog Diseases / Q000139:chemically induced / Q000209:etiology*; D004285:Dogs; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D005260:Female; D005270:Femur Head / Q000601:surgery; D006221:Halothane / Q000009:adverse effects*; D007668:Kidney / Q000473:pathology; D009395:Nephritis, Interstitial / Q000139:chemically induced / Q000209:etiology / Q000662:veterinary*; D010894:Piroxicam / Q000627:therapeutic use; D011183:Postoperative Complications / Q000139:chemically induced / Q000209:etiology / Q000662:veterinary; D013411:Sulfadiazine / Q000009:adverse effects*; D014295:Trimethoprim / Q000009:adverse effects*; D000096926:Benzenesulfonamides
D000892:Anti-Infective Agents, Urinary; D003002:Clonixin; D004338:Drug Combinations; D006221:Halothane; D010894:Piroxicam; D013411:Sulfadiazine; D014295:Trimethoprim; C024873:sulfadiazine, trimethoprim drug combination; D000096926:Benzenesulfonamides; C014558:flunixin meglumine