Neuropsychological assessment in MS: clinical, neurophysiological and neuroradiological relationships.
We assessed cognitive performance and its relationship with clinical and anatomic disease severity in MS with mild to moderate handicap; 34 definite MS and 18 healthy subjects matched for age and education were submitted to a neuropsychological test battery. Both groups were examined for anxiety. MS patients underwent magnetic resonance imaging examination. MS performed worse than controls on all WAIS-P subtests and had learning, short- and long-term verbal memory impairment. Cognitive deficits were not related to abnormal emotional states, but were found to be associated with attentional process and information-processing speed impairment. Cognitive impairment did not correlate with severity of physical disability. The most severe memory deficits were found in patients with extensive periventricular damage.
Maurelli
M
M
Neurological Institute C. Mondino, University of Pavia, Italy.
Marchioni
E
E
Cerretano
R
R
Bosone
D
D
Bergamaschi
R
R
Citterio
A
A
Martelli
A
A
Sibilla
L
L
Savoldi
F
F
D000328:Adult; D001143:Arousal / Q000502:physiology; D001288:Attention / Q000502:physiology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology; D002552:Cerebral Ventricles / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008606:Mental Processes / Q000502:physiology; D011939:Mental Recall / Q000502:physiology; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology*; D019965:Neurocognitive Disorders / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology*; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D012153:Retention, Psychology / Q000502:physiology; D014888:Wechsler Scales