Porcine model for studying the passage of non-depolarizing neuromuscular blockers through the blood-brain barrier.
A method has been developed for blood-brain barrier disruption to provide reproducible access to the cerebrospinal fluid of the cerebello-medullary cistern. The technique was used successfully to investigate transfer of pancuronium to the cerebral CSF compartment in pigs. After osmotic disruption of the blood-brain barrier, pancuronium concentrations increased significantly in the cerebrospinal fluid.
Werba
A
A
Clinic of Anaesthesia, University of Vienna, Austria.
Gilly
H
H
Weindlmayr-Goettel
M
M
Spiss
C K
CK
Steinbereithner
K
K
Czech
T
T
Agoston
S
S
D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D017536:Carotid Artery, Common; D008026:Ligation; D008954:Models, Biological; D003473:Neuromuscular Nondepolarizing Agents / Q000493:pharmacokinetics*; D010197:Pancuronium / Q000097:blood / Q000134:cerebrospinal fluid; D013552:Swine
D003473:Neuromuscular Nondepolarizing Agents; D010197:Pancuronium