title: Pharmacokinetics of nicotinamide and its effect on blood pressure, pulse and body temperature in normal human volunteers.
abstract: The pharmacokinetics of nicotinamide were studied in four human volunteers after oral doses of 1-6 g. Plasma concentrations and clearance rates of the vitamin were found to be dose-dependent, with a half-life of approximately 7-9 h for the two highest doses administered (4 and 6 g), approximately 4 h with 2 g and approximately 1.5 h with a 1-g dose. Peak concentrations ranged from 0.7 to 1.1 mumol.ml-1 after a 6-g dose. The time to reach peak plasma concentration was dose independent with a broad range from 0.73 to 3 h. In this study, nicotinamide had no detectable effect on blood pressure, pulse or body temperature.
authors.affiliation: Cancer Research Campaign Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, UK.
authors.forename: M R
authors.initials: MR
authors.lastname: Stratford
authors.forename: A
authors.initials: A
authors.lastname: Rojas
authors.forename: D W
authors.initials: DW
authors.lastname: Hall
authors.forename: M F
authors.initials: MF
authors.lastname: Dennis
authors.forename: S
authors.initials: S
authors.lastname: Dische
authors.forename: M C
authors.initials: MC
authors.lastname: Joiner
authors.forename: R J
authors.initials: RJ
authors.lastname: Hodgkiss
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects*; D002245:Carbon Dioxide; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D009536:Niacinamide / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology*; D010100:Oxygen; D011674:Pulse / Q000187:drug effects*; D011838:Radiation-Sensitizing Agents
chemical_list: D011838:Radiation-Sensitizing Agents; D002245:Carbon Dioxide; D009536:Niacinamide; C011700:carbogen; D010100:Oxygen