Vitiligo is associated with a significant increase in HLA-A30, Cw6 and DQw3 and a decrease in C4AQ0 in northern Italian patients.
HLA polymorphisms of class I (HLA-A, B, C) of class II (HLA-DR, DQ) and of class III (C4A, C4B, BF) were investigated in 93 Northern Italian patients affected with vitiligo and in 388 controls. Vitiligo patients had significant increases in HLA-A30 (corrected p, pc = 0.0144), Cw6 (pc = 0.0189), DQw3 (pc less than 0.0003) and a significant decrease in C4AQ0 (pc = 0.003). Nonfamilial vitiligo is marked by increases in HLA-A30 and DQw3. Extensive vitiligo is marked by increases in HLA-A30 and Cw6. These findings suggest that immunogenetic mechanisms may be responsible for vitiligo and that unique HLA phenotypes may influence the expression of vitiligo in this population.
Orecchia
G
G
Clinica Dermatologica dell'Università di Pavia, Italy.
Perfetti
L
L
Malagoli
P
P
Borghini
F
F
Kipervarg
Y
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D004586:Electrophoresis; D005260:Female; D015234:HLA-A Antigens / Q000097:blood*; D015236:HLA-C Antigens / Q000097:blood*; D006683:HLA-DQ Antigens / Q000097:blood*; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000276:immunology; D014820:Vitiligo / Q000235:genetics / Q000276:immunology*
D015234:HLA-A Antigens; C069526:HLA-A*30 antigen; D015236:HLA-C Antigens; C528994:HLA-C*06 antigen; D006683:HLA-DQ Antigens; C051569:HLA-DQ3 antigen