Two-dimensional and deuterium-induced, differential-isotope-shift nuclear magnetic resonance characterization of potassium sucrose octasulfate and sucralfate.
Two-dimensional and deuterium-induced, differential-isotope-shift NMR measurements have made it possible to assign completely all of the 1H and 13C resonances of potassium sucrose octasulfate (K8SOS) and thereby prove complete sulfation of the sugar moiety during synthesis. In addition, a comparison of the 13C NMR chemical shifts obtained for K8SOS and sucralfate made it possible to demonstrate that the sugar moiety in sucralfate is sucrose octasulfate (SOS8-). Finally, deuterium-induced, differential-isotope-shift and 13C NMR techniques were shown to be useful tools for detecting and characterizing carbon-containing impurities and hydrolysis products in solutions containing SOS8-.
Silvey
G L
GL
Marion Merrell Dow Inc., Kansas City, MO 64137.
D002240:Carbohydrate Sequence; D002247:Carbon Isotopes; D003903:Deuterium; D006868:Hydrolysis; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008969:Molecular Sequence Data; D013057:Spectrum Analysis / Q000379:methods; D013392:Sucralfate / Q000737:chemistry*; D013395:Sucrose / Q000031:analogs & derivatives* / Q000737:chemistry; D013455:Sulfur / Q000737:chemistry
D002247:Carbon Isotopes; D013392:Sucralfate; D013395:Sucrose; D013455:Sulfur; D003903:Deuterium; C053081:sucrose octasulfate