4-Methyltrityl (Mtt): a new protecting group for the side chain protection of Asn and Gln in solid-phase peptide synthesis.
The trityl group was recently introduced for the protection of the side chain carboxamide function of asparagine and glutamine. The 4-methyltrityl (Mtt) group, a structural modification of trityl, is presented here and allows more rapid cleavage from the protected peptides. Procedures for the introduction of the group and comparative cleavage reactions are also presented.
Sax
B
B
Bachem Feinchemikalien AG, Switzerland.
Dick
F
F
Tanner
R
R
Gosteli
J
J
D000595:Amino Acid Sequence; D001216:Asparagine / Q000737:chemistry*; D005998:Glycine / Q000737:chemistry*; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry*; D014320:Triphenylmethyl Compounds / Q000737:chemistry*
D010455:Peptides; D014320:Triphenylmethyl Compounds; C078003:4-methyltriphenylcarbinol; D001216:Asparagine; D005998:Glycine