title: Motor stimulation response by technetium-99m hexamethylpropylene amine oxime split-dose method and single photon emission tomography.
abstract: We applied the technetium-99m hexamethylpropylene amine oxime (99mTc-HMPAO) split-dose method in order to evaluate the feasibility of assessing cerebral blood flow (CBF) changes with single photon emission tomography (SPET) during a motor activation task. Eleven normal subjects were studied using the Tomomatic 564 (Medimatic, DK). Five subjects were studied twice at rest and 6 subjects at rest and during a motor task performance (finger opposition movements). A total of 28 mCi of 99mTc-HMPAO was injected in 2 doses with a 1:3 ratio. The first scan was obtained after injection of 7 mCi at rest in all subjects. The second scan was obtained a few minutes later, after injection of the remaining dose (21 mCi), under similar resting conditions or during a motor task performance. The mean brain uptake was proportional to the amount of tracer injected and to the acquisition time for both the first scan (5263 +/- 1266 counts x mCi x min) and the second (5034.4 +/- 966 counts x mCi x min). The grey/white matter ratio was 1.67 +/- 0.019 and 1.67 +/- 0.097 for the two scans, respectively. A three-way analysis of variance (ANOVA) for repeated measure showed no significant effects of side, slice and region of interest (ROI) on the CBF in the 5 subjects studied twice at rest, and the mean regional CBF change was -0.2% +/- 5%.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Neurological Sciences, University of Rome La Sapienza, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Pantano
authors.forename: V
authors.initials: V
authors.lastname: Di Piero
authors.forename: M
authors.initials: M
authors.lastname: Ricci
authors.forename: C
authors.initials: C
authors.lastname: Fieschi
authors.forename: L
authors.initials: L
authors.lastname: Bozzao
authors.forename: G L
authors.initials: GL
authors.lastname: Lenzi
mesh_terms: D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D009044:Motor Cortex / Q000098:blood supply* / Q000000981:diagnostic imaging; D015609:Organotechnetium Compounds; D010091:Oximes; D013382:Subtraction Technique; D019690:Technetium Tc 99m Exametazime; D014055:Tomography, Emission-Computed / Q000379:methods*
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime