title: [LDL cholesterol apheresis by adsorption to dextran sulfate].
abstract: Extracorporeal LDL cholesterol elimination may be the sole successful treatment in familial hypercholesterolemia. By treatment of 41 plasma both total cholesterol and LDL cholesterol were lowered by 69 +/- 1% and 78 +/- 1%, respectively. HDL cholesterol was decreased by 24 +/- 3%. This could be explained both by hemodilution (hematocrit was decreased by 9.3 +/- 2.8%) and unspecific adsorption of various plasma proteins (-15.3 +/- 3.7 g/l, i.e. -22 +/- 4%). Protein electrophoresis showed different affinities of the protein fractions. These data suggest that LDL apheresis by dextran sulfate is an effective method for the elimination of LDL cholesterol. However, other proteins besides apolipoprotein B are adsorbed to dextran sulfate.
authors.affiliation: Sektion Nephrologie, Universitätsklinik Ulm, FRG.
authors.forename: R W
authors.initials: RW
authors.lastname: Grunewald
authors.forename: H H
authors.initials: HH
authors.lastname: Ditschuneit
authors.forename: J
authors.initials: J
authors.lastname: Klein
authors.forename: W
authors.initials: W
authors.lastname: König
authors.forename: J M
authors.initials: JM
authors.lastname: Grunewald
authors.forename: H E
authors.initials: HE
authors.lastname: Franz
mesh_terms: D000327:Adsorption; D001055:Apolipoproteins B / Q000097:blood*; D001781:Blood Component Removal / Q000295:instrumentation*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D016264:Dextran Sulfate; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000628:therapy*; D014280:Triglycerides / Q000097:blood
chemical_list: D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D016264:Dextran Sulfate; D002784:Cholesterol
vernacular_title: LDL-Cholesterin-Apherese durch Adsorption an Dextransulfat.