Benastatins A and B, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. II. Structure determination of benastatins A and B.
Benastatins A and B, new inhibitors of glutathione S-transferase, have been isolated from the culture broth of Streptomyces sp. MI384-DF12. By X-ray crystallography, benastatin A was determined to be 8,13-dihydro-1,7,9,11-tetrahydroxy-13-dimethyl-8-oxo-3-pentyl- benzo[a]naphthacene-2-carboxylic acid. The structure of benastatin B was elucidated by NMR studies.
Aoyama
T
T
Institute of Microbial Chemistry, Tokyo, Japan.
Naganawa
H
H
Muraoka
Y
Y
Nakamura
H
H
Aoyagi
T
T
Takeuchi
T
T
Iitaka
Y
Y
D001551:Benz(a)Anthracenes / Q000737:chemistry* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors*; D013058:Mass Spectrometry; D009279:Naphthacenes; D013302:Streptomyces / Q000737:chemistry* / Q000235:genetics; D014961:X-Ray Diffraction
D001551:Benz(a)Anthracenes; D004791:Enzyme Inhibitors; D009279:Naphthacenes; C077629:benastatin A; C077630:benastatin B; D005982:Glutathione Transferase