Marked decrease of A10 dopamine neuronal firing during ethanol withdrawal syndrome in rats.
The electrophysiological activity of mesoaccumbens dopaminergic neurons was monitored during the ethanol-withdrawal syndrome in ethanol-dependent and in control rats. Spontaneous firing was reduced by about half in ethanol-dependent rats as compared to controls. Likewise, the number of spikes/burst was also reduced in ethanol-dependent rats. These results are consistent with the reduction in dopamine release observed during ethanol-withdrawal syndrome and may provide the basis for the aversive effects of the ethanol-withdrawal syndrome.
Diana
M
M
B.B. Brodie Department of Neuroscience, University of Cagliari, Italy.
Pistis
M
M
Muntoni
A
A
Rossetti
Z L
ZL
Gessa
G
G
D000818:Animals; D004298:Dopamine / Q000032:analysis; D000431:Ethanol / Q000009:adverse effects*; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*
D000431:Ethanol; D004298:Dopamine