title: [A case of acetaminophen-induced pneumonitis].
abstract: A 20-year-old woman took 1.2 g of acetaminophen for toothache. She subsequently developed a dry cough, pyrexia, and dyspnea. Chest X-ray revealed diffuse reticulo-nodular shadows in both lung fields. Broncho-alveolar lavage examination showed a marked increase in the total cell number and an increase in the percentage of eosinophils, neutrophils, and lymphocytes. Because drug-induced pneumonitis was suspected, all drugs were stopped and she was administered methylprednisolone. Consequently her symptoms resolved, and pulmonary function and chest X-ray findings improved remarkably. The lymphocyte stimulation test was positive for Norshin and its acetaminophen element. Based on these findings, the diagnosis of acetaminophen-induced pneumonitis was made. Acetaminophen intoxication is well-known, but to our knowledge this is the first reported case of acetaminophen-induced allergic pneumonitis in Japan.
authors.affiliation: Department of Internal Medicine, Hiroshima City Hospital, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kitaguchi
authors.forename: T
authors.initials: T
authors.lastname: Miyazawa
authors.forename: M
authors.initials: M
authors.lastname: Minesita
authors.forename: M
authors.initials: M
authors.lastname: Doi
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Yamakido
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D000328:Adult; D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced*; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans
chemical_list: D000082:Acetaminophen