Alcohol consumption and biological markers for alcoholism in idiopathic dilated cardiomyopathy: a case-controlled study.
The aim of this study was to compare alcohol consumption and biological markers for alcoholism in a population of 23 men (57 +/- 8 years) admitted to hospital with idiopathic dilated cardiomyopathy (DCM), and a control group of 46 men (54 +/- 8 years) with coronary artery disease, matched for age. The DCM group had a higher daily alcohol consumption (82 g/day vs. 30 g/day, P < 0.0002). This difference was greater for the consumption of wine (63 g/day in the DCM group vs. 24 g/day in the control group, P < 0.002). Duration of regular daily alcohol consumption was longer in DCM patients (34 years vs. 22 years, P < 0.01) as well as duration of heavy alcohol consumption (> 60 g/day) (25 years vs. 10 years, P < 0.001). Among the biological markers, only the serum levels of immunoglobulin A were significantly increased in the DCM group (3.7 g/l vs. 2.7 g/l, P < 0.03). In this French population, alcohol is strongly linked to DCM. Biological markers appear to be poor predictors of alcohol intoxication in this so-called 'idiopathic' myocardial disease.
Gillet
C
C
Department of Alcohology, Hopital Fournier, Nancy, France.
Juilliere
Y
Y
Pirollet
P
P
Aubin
H J
HJ
Thouvenin
A
A
Danchin
N
N
Cherrier
F
F
Paille
F
F
D000428:Alcohol Drinking / Q000009:adverse effects*; D000437:Alcoholism / Q000150:complications* / Q000175:diagnosis; D015415:Biomarkers; D002310:Cardiomyopathy, Alcoholic / Q000209:etiology*; D002311:Cardiomyopathy, Dilated / Q000209:etiology*; D016022:Case-Control Studies; D003327:Coronary Disease / Q000150:complications / Q000175:diagnosis; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D015415:Biomarkers