title: Pharmacokinetics and pharmacodynamics of erythropoietin during therapy in an infant with renal failure.
abstract: We treated an infant with anemia and chronic renal failure with recombinant human erythropoietin (300 to 750 U/kg subcutaneously per week) and iron (6 mg/kg enterally) from 1 to 4 months of age. A suboptimal pharmacodynamic response was seen at the lower dose. This may have been due to developmental erythropoietin pharmacokinetic differences, that is, relatively greater neonatal plasma clearance and steady-state volume of distribution compared with those in adults.
authors.affiliation: Department of Pediatrics, College of Medicine, University of Iowa, Iowa City.
authors.forename: P J
authors.initials: PJ
authors.lastname: Kling
authors.forename: J A
authors.initials: JA
authors.lastname: Widness
authors.forename: E N
authors.initials: EN
authors.lastname: Guillery
authors.forename: P
authors.initials: P
authors.lastname: Veng-Pedersen
authors.forename: C
authors.initials: C
authors.lastname: Peters
authors.forename: P A
authors.initials: PA
authors.lastname: DeAlarcon
mesh_terms: D000740:Anemia / Q000628:therapy; D004921:Erythropoietin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D007676:Kidney Failure, Chronic / Q000150:complications / Q000378:metabolism*; D008297:Male
chemical_list: D004921:Erythropoietin