Analgesic components from bornean medicinal plants, Tabernaemontana pauciflora Blume and Tabernaemontana pandacaqui Poir.
The analgesic components were isolated from a Bornean medicinal plant, Tabernaemontana pauciflora Blume (syn. Ervatamia blumeana Mark gr.), and the major components were identified as coronaridine and 3-(2-oxopropyl)coronaridine. Four minor components were estimated to be 5R- and 5S-(2-oxopropyl)coronaridine, 3-(2-oxopropyl)voacangine and 3,3'-(oxopropyl)dicoronaridine, which might be produced during the isolation process. Voacangine was also isolated as a major component of T. pandacaqui Poir. Coronaridine and voacangine exhibited significant analgesic and hypothermic effects in mice at a dose of 25 mg/kg, p.o., while 3-(2-oxopropyl)coronaridine was less effective. The former two compounds also revealed a surface anesthesia.
Okuyama
E
E
Faculty of Pharmaceutical Sciences, Chiba University, Japan.
Gao
L H
LH
Yamazaki
M
M
D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001893:Borneo; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010946:Plants, Medicinal / Q000737:chemistry*
D000700:Analgesics