Effect of aspirin on isoproterenol induced myocardial infarction--a pilot study.
Effect of aspirin (1.2 mg/100 g body wt orally for 30 days) on myocardial infarction induced by isoproterenol (200 mg/kg body wt, subcutaneously for 2 days) has been studied in rats using activities of creatine kinase, aspartate amino transaminase, alanine amino transaminase and lactate dehydrogenase and levels of lipid peroxides as standard markers. Aspirin treatment is found to counteract the effect of isoproterenol on lipid peroxide formation and associated enzyme changes in serum and heart.
Manjula
T S
TS
Department of Biochemistry, University of Madras.
Geetha
A
A
Devi
C S
CS
D000284:Administration, Oral; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology*; D003402:Creatine Kinase / Q000032:analysis; D007545:Isoproterenol / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008054:Lipid Peroxides / Q000032:analysis / Q000097:blood; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced / Q000188:drug therapy*; D009206:Myocardium / Q000201:enzymology; D010865:Pilot Projects; D051381:Rats; D000637:Transaminases / Q000032:analysis
D008054:Lipid Peroxides; D007770:L-Lactate Dehydrogenase; D000637:Transaminases; D003402:Creatine Kinase; D007545:Isoproterenol; D001241:Aspirin