[Control of renal tubular regeneration].
Tubular necrosis induced by various drugs (aminoglycosides, platinum-based anticancer agents) elicits a process of renal tissue repair which involves an increase of cell turnover. The proliferative response remains commensurate with the degree of tubular injury and occurs primarily in the area of tubular epithelium which has suffered injury. After acute renal necrosis, tubular regeneration is associated with a transient dedifferentiation of epithelial cells. This tissue reaction is controlled and leads in most cases to a complete reepithelialization of injured tubules and consequently to a full restoration of normal kidney functions. Recent experimental evidences suggest that EGF (Epidermal growth factor) plays a prominent role in the control of this repair process. By immunocytochemical and biochemical methods we have observed in regenerating kidneys a diminution of the membrane-bound precursor of EGF (prepro-EGF) in distal tubules. Concomitantly, by electron microscopy, EGF immunoreactivity is detected on basolateral membranes of proximal tubules. These experimental data suggest that EGF precursor might be converted into a low molecular weight diffusible factor. The latter is able to interact with the receptors localized on the basolateral membranes of proximal tubules and to induce the tissue repair process.
Stiennon-Heuson
J A
JA
Service d'Histologie, Université de Mons-Hainaut.
D064420:Drug-Related Side Effects and Adverse Reactions; D004815:Epidermal Growth Factor / Q000502:physiology; D004848:Epithelium / Q000502:physiology / Q000648:ultrastructure; D006801:Humans; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced / Q000503:physiopathology*; D007684:Kidney Tubules / Q000503:physiopathology*; D008854:Microscopy, Electron; D011498:Protein Precursors / Q000502:physiology; D012038:Regeneration
D011498:Protein Precursors; C042652:epidermal growth factor precursor; D004815:Epidermal Growth Factor
Contrôle de la régénération tubulaire rénale.