A physical map of a 1.3-Mb region on the long arm of chromosome 12, spanning the GLI and LRP loci.
We have used pulsed-field gel electrophoresis to construct a long-range restriction map spanning more than 1.3 million bp of the q13-q14 segment of chromosome 12. Within this region lie the genes coding for the gli oncogene and the low-density lipoprotein receptor-related protein (LRP). The distance between the genes is about 200-300 kb. We also observe a methylation-free island 3' to the LRP gene.
Forus
A
A
Department of Tumor Biology, Norwegian Radium Hospital, Montebello, Oslo.
Myklebost
O
O
D002881:Chromosomes, Human, Pair 12; D016521:Electrophoresis, Gel, Pulsed-Field; D006801:Humans; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D008565:Membrane Proteins; D009693:Nucleic Acid Hybridization; D015347:RNA Probes; D011971:Receptors, Immunologic / Q000235:genetics*; D015183:Restriction Mapping; D016335:Zinc Fingers / Q000235:genetics*
D026503:Low Density Lipoprotein Receptor-Related Protein-1; D008565:Membrane Proteins; D015347:RNA Probes; D011971:Receptors, Immunologic