Synthesis and some pharmacological properties of 1,2-amino ethers with natural monoterpene structures.
Synthesis and physicochemical and pharmacological properties of 10 analogs of 2-[2-(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethoxy]N, N-diethylamino ethane (3) have been described. The compounds possess toxicity close to or lower than the parent compound--myrtecaine, have no antiarrhythmic activity but some of them (15, 16, 22, 24), similarly as compound 3, show quite strong local anesthetic action.
Siemieniuk
A
A
Institute of Organic and Physical Chemistry, Polytechnical University, Wrocław, Poland.
Szałkowska-Pagowska
H
H
Lochyński
S
S
Piatkowski
K
K
Filipek
B
B
Krupińska
J
J
Czarnecki
R
R
Librowski
T
T
Szymańska
I
I
D000772:Anesthesia, Local; D000779:Anesthetics, Local / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000517:prevention & control; D001767:Blinking / Q000187:drug effects; D003315:Cornea / Q000187:drug effects; D004562:Electrocardiography / Q000187:drug effects; D006168:Guinea Pigs; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D013729:Terpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*
D000779:Anesthetics, Local; D013729:Terpenes; C011940:myrtecaine