Mechanism of immune complex-mediated inner ear diseases.
Tissues of the stria vascularis of normal rabbits were collected as cochlear antigen and injected into the foot pad of guinea pigs. The mechanism of development of endolymphatic hydrops was studied by the tracer method. Damage to the capillary endothelium and an increase in vascular permeability were found in the stria vascularis. Therefore, we studied patients with a raised level of immunoglobulin (Ig) G-class circulating immune complexes (CICs). Hearing loss was found in 3 of 22 patients with significantly elevated IgG CIC levels (13.6%). The relationship between inner ear disease and the presence of CIC was considered to be very significant. The possible mechanism of CIC-mediated inner ear diseases is discussed.
Harada
T
T
Department of Otolaryngology, Osaka University Medical School, Japan.
Sano
M
M
Sakagami
M
M
Ogino
S
S
Matsunaga
T
T
D000328:Adult; D000818:Animals; D000936:Antigen-Antibody Complex / Q000032:analysis; D005260:Female; D006168:Guinea Pigs; D006319:Hearing Loss, Sensorineural / Q000276:immunology / Q000473:pathology; D006801:Humans; D007105:Immune Complex Diseases / Q000276:immunology / Q000473:pathology*; D007114:Immunization; D007074:Immunoglobulin G / Q000032:analysis; D007759:Labyrinth Diseases / Q000276:immunology / Q000473:pathology*; D008297:Male; D013316:Stria Vascularis / Q000648:ultrastructure
D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G