[Change in concentration of cholesterol and lipoprotein fractions of rabbit blood serum in the dynamics of hypercholesterolemia].
Three quantitatively different periods have been detected as a result of 21-week monitoring of blood serum total cholesterol at hypercholesterolemia in rabbits. The first of them (4th week) ends by a relative decrease of cholesterol concentration: the second one (4th-13th weeks) is characterized by its sharp increase; in the third period (13th-21st weeks) the sterol accumulation slows down. Concentration variations of all main lipoprotein fractions are observed in each of the above periods. Their specific features enable us to suppose that in the first period the cholesterol transport system is activated which, probably, reflects the development of adaptation mechanisms of hypocholesterolemia. The second period can be considered as a transition stage from norm to pathology and is most likely, connected with atherogenesis induction. In the third period, in spite of relative stabilization of total cholesterol level clear signs of hyperbeta and hypoalpha dyslipoproteinemias are observed.
Bozhko
H Kh
HKh
Kulabukhov
V M
VM
Voloshin
V P
VP
D000818:Animals; D002784:Cholesterol / Q000097:blood*; D006937:Hypercholesterolemia / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D011817:Rabbits
D008074:Lipoproteins; D002784:Cholesterol
Osoblyvosty zmin kontsentratsiï kholesterynu ta fraktsiĭ lipoproteïniv syrovatky krovy kroliv u dynamitsi hiperkholesterynemiï.