Cutaneous pleomorphic large cell lymphoma.
The case of a primary cutaneous pleomorphic large cell lymphoma occurring in a twenty-one-year-old woman who presented with a blue-reddish nodule on her left cheek of three months' duration is presented. The tumor consisted of pleomorphic blast cells showing high mitotic activity. On immunohistochemical examination, the majority of the tumor cells expressed CD 3 (Leu-4), CD 4 (Leu-3), HLA-DR CD 30 (Ki-1/Ber-H 2), and CD 25 (IL2 receptor). Twenty-two months after excision of the tumor there is no detectable systemic spread of the lymphoma. This case provides further evidence for recent observations that primary cutaneous Ki-1-positive large cell lymphomas without lymph node involvement may have a favorable prognosis after local treatment despite showing histologic pattern of malignancy.
von den Driesch
P
P
Department of Dermatology, University of Erlangen-Nürnberg, Germany.
Bivolarevic
I
I
Peters
K P
KP
Hornstein
O P
OP
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D002610:Cheek; D005153:Facial Neoplasms / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D011379:Prognosis
D015703:Antigens, CD