[Analysis of the role of calcium in analgesic action of non-narcotic analgesics and calcium channel blockers].
In the mice hot-plate test we have compared analgesic effect of calcium channel blockers and new non-narcotic analgesic antiinflammatory agent PV-107: verapamil > fenigidin > PV-107. Simultaneously we have shown strong correlation (r - 0.82) between analgesic effect and 45Ca2+ efflux of cardiac membrane in depolarizing media in vitro.
Trinus
F P
FP
Kurskiĭ
M D
MD
Gubskiĭ
Iu I
IuI
Bukhtiarova
T A
TA
D000700:Analgesics; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism / Q000502:physiology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009543:Nifedipine / Q000494:pharmacology; D010147:Pain Measurement; D013997:Time Factors; D014700:Verapamil / Q000494:pharmacology
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002121:Calcium Channel Blockers; D014700:Verapamil; D009543:Nifedipine; D002118:Calcium
Analiz roli kal'tsiia v obezbolivaiushchem deĭstvii nenarkoticheskikh anal'getikov i blokatorov kal'tsievykh kanalov.