[Changes in impulse activity of neurons of the CA3 area of the hippocampus under the effects of neuromodulator neurotropin].
Neurotropin (Nippon Zoki Co, Ltd) effects on firing patterns of the CA 3 hippocampus neurons in rabbits under a 24-h food deprivation was studied. Neuronal firing was recorded in a state of hunger (40 neurons) and under neurotropin (27 neurons) injected through a catheter implanted into the lateral brain ventricles. Initially, in 20% of neurons histograms had a bimodal interspike interval distribution: 1.5-25 ms and 100-400 ms. Neurotropin (50 microliters) increased the baseline spike rate regularity of hippocampus neurons. Histograms had a monomodal interspike interval distribution. Neurotropin (70 microliters) inhibited firing patterns and histograms, had trimodal interspike interval distribution: 1.5-5 ms; 250-400 ms and 1000 ms. Thus, these data suggested the involvement of neuro-immuno-modulator mechanisms in organization of firing patterns in rabbits.
Shamaev
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D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D004594:Electrophysiology; D005508:Food Deprivation; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D007276:Injections, Intraventricular; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D011134:Polysaccharides / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology*; D011817:Rabbits; D012815:Signal Processing, Computer-Assisted
D000276:Adjuvants, Immunologic; D011134:Polysaccharides; C010491:neurotropin
Izmenenie impul'snoĭ aktivnosti neĭronov polia CA3 gippokampa pod deĭstviem neĭroimmunomoduliatora neĭrotropina.