title: Humoral responses to type I collagen after surgical curettage procedures employing bovine collagen implants.
abstract: Freeze-dried bovine type I collagen was implanted into periodontally diseased sites of 11 patients in an effort to repair the affected site. Peripheral blood samples taken at 0, 6 and 12 wk were assayed for antibody to human and bovine collagen using an enzyme-linked immunosorbent assay and compared with samples from 9 control subjects. Antibody levels to both human and bovine collagen, which were present at significantly higher levels in the patients at 0 wk than in the control subjects (P less than 0.01 for human and bovine), were significantly lower at 6 wk than at zero time (P less than 0.05 and P less than 0.01 for human and bovine collagens, respectively). At 12 wk post-implantation, the antibody level to human collagen still remained significantly lower (P less than 0.05) than zero time levels but not in respect of the antibody to bovine collagen.
authors.affiliation: Department of Periodontology, University of Wales College of Medicine, Heath Park, Cardiff, UK.
authors.forename: P
authors.initials: P
authors.lastname: Hyder
authors.forename: G
authors.initials: G
authors.lastname: Singh
authors.forename: S
authors.initials: S
authors.lastname: Adam
mesh_terms: D000328:Adult; D000818:Animals; D000917:Antibody Formation; D001672:Biocompatible Materials; D002417:Cattle; D003094:Collagen / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016557:Guided Tissue Regeneration, Periodontal; D006801:Humans; D008297:Male; D008875:Middle Aged; D010510:Periodontal Diseases / Q000276:immunology / Q000601:surgery*; D013357:Subgingival Curettage
chemical_list: D001672:Biocompatible Materials; D003094:Collagen