title: Brain atrophy on computerized axial tomography scans: interaction of age, diabetes and general morbidity.
abstract: We evaluated, retrospectively, the occurrence of brain atrophy in all patients (n = 416) with a brain CT scan performed during a 3-month period in 1989 at the Tampere University Central Hospital. Age, diabetes, hypertension, chronic cerebrovascular disorders and an increasing number of medications were associated with brain atrophy in the log-linear models. We suggest that the effect of various systemic medical disorders on the brain requires consideration when evaluating and assessing physiological ageing of the brain.
authors.affiliation: Department of Neurology, Tampere University Central Hospital, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Pirttilä
authors.forename: R
authors.initials: R
authors.lastname: Järvenpää
authors.forename: P
authors.initials: P
authors.lastname: Laippala
authors.forename: H
authors.initials: H
authors.lastname: Frey
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000473:pathology*; D001284:Atrophy / Q000000981:diagnostic imaging; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging / Q000473:pathology*; D003920:Diabetes Mellitus / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D016014:Linear Models; D008875:Middle Aged; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed