Dehydroepiandrosterone enhances the hypnotic and hypothermic effects of ethanol and pentobarbital.
Recent reports have indicated that the neurosteroid dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) interact with the GABAA receptor complex. Because many of the behavioral effects of ethanol and pentobarbital are due to activity at this complex, DHEA and DHEAS were tested for their ability to interact with the hypnotic and hypothermic effects of ethanol and pentobarbital. DHEA, but not DHEAS, causes a dose-dependent increase in the sleep time induced by either ethanol or pentobarbital. At 20 mg/kg, DHEA and DHEAS themselves cause a fall in body temperature. DHEA enhances the hypothermic effect of both ethanol and pentobarbital. DHEAS enhances the hypothermic effect of ethanol, but with pentobarbital it only delays the return of body temperature to baseline levels. Neither DHEA nor DHEAS affects the metabolism of ethanol.
Melchior
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CL
Brentwood Division Research, West Los Angeles Veterans Administration, CA 90073.
Ritzmann
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RF
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D003687:Dehydroepiandrosterone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D010424:Pentobarbital / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D006993:Hypnotics and Sedatives; D000431:Ethanol; D003687:Dehydroepiandrosterone; D005680:gamma-Aminobutyric Acid; D010424:Pentobarbital