Selective IgM deficiency and abnormal B-cell response in a foal.
Selective IgM deficiency was diagnosed in a 3-month-old Standardbred colt that was referred for chronic respiratory tract disease. Immunoglobulin quantification revealed normal IgG and IgA concentrations, but undetectable IgM concentration. Stimulation of blood lymphocytes with the T-cell mitogens concanavalin A and phytohemagglutinin yielded results within the normal range. However, stimulation with the B-cell mitogen lipopolysaccharide produced no response. A B-cell defect similar to that associated with several immunodeficiency disorders in people was suggested as the cause of the IgM deficiency in this colt.
Weldon
A D
AD
Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.
Zhang
C
C
Antczak
D F
DF
Rebhun
W C
WC
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002908:Chronic Disease; D003937:Diagnosis, Differential; D004406:Dysgammaglobulinemia / Q000150:complications / Q000276:immunology / Q000662:veterinary*; D005434:Flow Cytometry / Q000662:veterinary; D006734:Horse Diseases / Q000209:etiology / Q000276:immunology*; D006736:Horses; D007111:Immunity, Cellular; D007075:Immunoglobulin M / Q000172:deficiency*; D008213:Lymphocyte Activation; D008297:Male; D012140:Respiratory Tract Diseases / Q000209:etiology / Q000662:veterinary*
D007075:Immunoglobulin M