A peptide from Schumanniophyton magnificum with anti-cobra venom activity.
Using the chick biventer cervicis preparation as a bioassay for antivenom activity, a peptide has been isolated from the aqueous extract of the bark of Schumanniophyton magnificum. The peptide was isolated and purified by a combination of reverse-phase and exclusion column chromatography, preparative TLC, and HPLC. The peptide has a relative molecular mass of about 6000 daltons and is similar in amino acid composition to the cardiotoxins present in snake venom. The isolated peptide showed dose-related inhibitions of the effects of cardiotoxin and total venom of cobra species using the chick biventer cervicis preparation.
Houghton
P J
PJ
Chelsea Department of Pharmacy, King's College London, U.K.
Osibogun
I M
IM
Bansal
S
S
D000818:Animals; D000997:Antivenins / Q000302:isolation & purification*; D002645:Chickens; D004546:Elapid Venoms / Q000037:antagonists & inhibitors*; D010940:Plant Proteins / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*
D000997:Antivenins; D004546:Elapid Venoms; D010940:Plant Proteins