title: [Increase of seizure threshold and resistance to stress in rats after immunization against fragment of diazepam-binding inhibitor].
abstract: White rats were immunized against fragment of diazepam-binding inhibitor octadecaneuropeptide (ODN) with conjugate ODN bovine serum albumin. This rats have reduced reactions of fear and anxiety in stress model of "open field" and in conflict Vogel test; their pain sensitivity ("tail flick" test) was lowered. The number and intensity of generalized seizure reactions after injection of pentylenetetrazole were decreased. The results show that active immunization to endogenous ODN has stress--protective and anti-seizure effects.
authors.forename: I P
authors.initials: IP
authors.lastname: Ashmarin
authors.forename: O P
authors.initials: OP
authors.lastname: Vakulina
authors.forename: V V
authors.initials: VV
authors.lastname: Rozhanets
authors.forename: V V
authors.initials: VV
authors.lastname: Maksimov
authors.forename: V V
authors.initials: VV
authors.lastname: Samukov
authors.forename: V V
authors.initials: VV
authors.lastname: Kalashnikov
authors.forename: G A
authors.initials: GA
authors.lastname: Mizenko
mesh_terms: D000818:Animals; D026261:Diazepam Binding Inhibitor; D007114:Immunization; D009479:Neuropeptides / Q000276:immunology*; D010147:Pain Measurement; D010433:Pentylenetetrazole; D010446:Peptide Fragments; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*; D013315:Stress, Psychological / Q000517:prevention & control*
chemical_list: D026261:Diazepam Binding Inhibitor; D009479:Neuropeptides; D010446:Peptide Fragments; C067529:diazepam binding inhibitor (33-50); D010433:Pentylenetetrazole
vernacular_title: Povyshenie sudorozhnogo poroga i ustoĭchivosti krys k stressu posle immunizatsii k fragmentu diazepam-sviazyvaiushchego ingibitora.