title: Glucocorticoid-induced DNA fragmentation: role of protein-kinase-C activity.
abstract: Glucocorticoid hormones (GCH) and IL-2 induce apoptotic cell death by a PKC-dependent mechanism. IL-4 counteracts apoptosis by inhibiting PKC activity. GCH and IL-2 show antagonistic effects on apoptosis when administered together. These data indicate that PKC activation in response to different stimuli can both enhance or reduce thymocyte survival.
authors.affiliation: Istituto di Farmacologia Medica, Perugia University Medical School, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Migliorati
authors.forename: M C
authors.initials: MC
authors.lastname: Pagliacci
authors.forename: F
authors.initials: F
authors.lastname: D'Adamio
authors.forename: F
authors.initials: F
authors.lastname: Crocicchio
authors.forename: I
authors.initials: I
authors.lastname: Nicoletti
authors.forename: C
authors.initials: C
authors.lastname: Riccardi
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D016923:Cell Death / Q000187:drug effects; D004247:DNA / Q000378:metabolism*; D003907:Dexamethasone / Q000494:pharmacology; D005434:Flow Cytometry; D005938:Glucocorticoids / Q000494:pharmacology*; D066298:In Vitro Techniques; D051379:Mice; D008809:Mice, Inbred C3H; D011493:Protein Kinase C / Q000378:metabolism*; D013601:T-Lymphocytes / Q000187:drug effects; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D005938:Glucocorticoids; D003907:Dexamethasone; D004247:DNA; D011493:Protein Kinase C; D013755:Tetradecanoylphorbol Acetate