title: HLA-DP polymorphism in Sudanese controls and patients with insulin-dependent diabetes mellitus.
abstract: Human leukocyte antigen (HLA) genes are candidates for susceptibility to insulin-dependent diabetes mellitus (IDDM). The association of IDDM with particular DR and DQ alleles has been reported in all populations studied, but its association with HLA-DP alleles has been controversial. To address this question we analyzed 19 DPB1 and 2 DPA1 alleles and their associations in well-characterized Sudanese (an admixture of Arab and Black) IDDM patients (n = 71) and ethnically matched controls (n = 86) using polymerase chain reaction-sequence specific oligonucleotide (PCR-SSO) typing. There were no significant differences between the patient and control groups in the DPB1 frequencies. DPB1*0201, *0401 and DPA1*01 were the most frequent alleles in both IDDM patients and control subjects. Significant positive and negative associations between DPB1 and DPA1 alleles were detected in both groups. A novel DPB1 allele included in DPB1*1701 was identified.
authors.affiliation: Faculty of Medicine, University of Gezira, Sudan.
authors.forename: M M
authors.initials: MM
authors.lastname: Magzoub
authors.forename: H A
authors.initials: HA
authors.lastname: Stephens
authors.forename: J A
authors.initials: JA
authors.lastname: Sachs
authors.forename: P A
authors.initials: PA
authors.lastname: Biro
authors.forename: S
authors.initials: S
authors.lastname: Cutbush
authors.forename: Z
authors.initials: Z
authors.lastname: Wu
authors.forename: G F
authors.initials: GF
authors.lastname: Bottazzo
mesh_terms: D000483:Alleles; D001345:Autoradiography; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000235:genetics*; D005838:Genotype; D006682:HLA-DP Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D015995:Prevalence; D013397:Sudan / Q000453:epidemiology
chemical_list: D006682:HLA-DP Antigens; D004247:DNA