title: Multiple sclerosis with very late onset.
abstract: Multiple sclerosis (MS) can present clinically after age 59, but only rarely. In a large MS population (N = 2,019), 0.6% of patients had their first symptom at age 60 or older. Of this group, six had clinically definite MS, two had laboratory-supported definite MS, and four had clinically probable MS. The onset at this age was characteristically a slow deterioration of motor function. Most (10 of 12) of these very late-onset patients had a progressive course of disease from onset.
authors.affiliation: Department of Medicine, University of British Columbia, Vancouver, Canada.
authors.forename: J P
authors.initials: JP
authors.lastname: Hooge
authors.forename: W K
authors.initials: WK
authors.lastname: Redekop
mesh_terms: D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D007136:Immunoglobulins / Q000134:cerebrospinal fluid; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009068:Movement; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000503:physiopathology*; D043025:Oligoclonal Bands; D013997:Time Factors
chemical_list: D007074:Immunoglobulin G; D007136:Immunoglobulins; D043025:Oligoclonal Bands