Sulpiride anxiogenic-like effect inhibition by a D1 dopamine receptor antagonist.
The increased latency to explore a white compartment from a black one into which a mouse has been introduced, appears to be correlated with its anxiety level. In this test, the D2 specific dopamine receptor antagonist (+/-) sulpiride dose dependently (5-40) mg kg-1 i.p.) increased this latency. This effect was suppressed by the D1 specific dopamine receptor antagonist SCH 23390 (25 micrograms kg-1 s.c.) which intrinsically displayed an apparent anxiolytic effect.
Simon
P
P
Unité de Neuropsychopharmacologie, URA 1170 du CNRS, Faculté de Médecine et Pharmacie de Rouen, Saint Etienne du Rouvray, France.
Panissaud
C
C
Costentin
J
J
D000818:Animals; D001007:Anxiety / Q000139:chemically induced / Q000517:prevention & control* / Q000523:psychology; D001522:Behavior, Animal / Q000187:drug effects; D001552:Benzazepines / Q000494:pharmacology*; D065127:Dopamine D2 Receptor Antagonists; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors*; D013469:Sulpiride / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D001552:Benzazepines; D065127:Dopamine D2 Receptor Antagonists; D017447:Receptors, Dopamine D1; D013469:Sulpiride