title: Early detection of changes in kidney function in workers exposed to solvents and heavy metals.
abstract: Increases in urine concentration of specific proteins have been proposed as early indicators of deleterious changes in kidney function. Four urinary proteins (albumin, superoxide dismutase, transferrin and N-acetyl-beta-D-glucosaminidase) were measured in workers exposed to heavy metals and solvents. None of the workers had clinical evidence of renal disease or hypertension. Workers exposed to mercury had a significant increase in urinary transferring, superoxide dismutase levels were slightly increased in workers exposed to solvents and lead, follow-up of these workers is needed to confirm that these changes predict late clinical deterioration of kidney functions.
authors.affiliation: Department of Biochemistry, Lady Davis Carmel Hospital, Haifa, Israel.
authors.forename: N
authors.initials: N
authors.lastname: Gruener
mesh_terms: D002617:Chemical Industry; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D007677:Kidney Function Tests; D007855:Lead Poisoning / Q000097:blood / Q000652:urine*; D008297:Male; D008628:Mercury / Q000633:toxicity*; D016273:Occupational Exposure; D012997:Solvents / Q000633:toxicity*; D013482:Superoxide Dismutase / Q000652:urine; D014168:Transferrin / Q000652:urine
chemical_list: D012997:Solvents; D014168:Transferrin; D013482:Superoxide Dismutase; D008628:Mercury