Acetylsalicylic acid and blood coagulation in the horse.
Equine blood may contain salicylic acid (SA) taken up as free acid or represents the metabolite of acetylsalicylic acid (ASA). To obtain information of SA in race horses we screened blood samples of trotting-horses routinely drawn to be analyzed for doping substances. The individual values determined followed a Gaussian distribution displaying a geometric mean of 19 ng SA per ml serum. A probit analysis revealed linear relationship (r = 0.995). Additional studies examined the antithrombotic efficacy of ASA in the horse. An oral dose of 300 mg ASA considerably elevated the bleeding time for more than 2 hours with concomitant SA serum levels between 800 and 1000 ng/ml. It is concluded that salicylate levels even below 1 microgram/ml serum bring about considerable pharmacologic effects such as prolongation of bleeding time, decrease in blood viscosity and possibly dilatation of blood vessels. These effects may improve the tissue supply with blood including oxygen.
Hagedorn
H W
HW
Institute of Pharmacology, Toxicology and Pharmacy, Klinikum Grosshadern, University of Munich.
Böck
M
M
Schulz
R
R
D000818:Animals; D001241:Aspirin / Q000097:blood* / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects*; D008401:Gas Chromatography-Mass Spectrometry; D006736:Horses / Q000097:blood*; D010974:Platelet Aggregation / Q000187:drug effects*; D012016:Reference Values
D001241:Aspirin