[The interaction of the Ca2(+)-channel blocker verapamil with cardiac glycosides in the rat kidney].
Strophanthine (0.1 mg/kg, i. v.) and digoxin (0.1 mg/kg, i. v.) increase blood supply of the cortex and medullary layer of the kidneys of anesthetized rats and significantly raise excretion of water and sodium by the kidneys. Verapamil, a blocker of Ca(2+)-channels (0.25 mg/kg, i. v.) attenuates the increment of the blood flow in the internal zone of the cortex and external zone of the medullary layer but does not prevent the rise of diuresis and excretion of sodium with urine under the action of the above-indicated drugs. The conclusion is drawn that realization of the vasodilatory effect of cardiac glycosides in the kidneys is partially connected with a lowering of the content of Ca2+ in myofibrils whereas formation of their tubular effect does not depend on the changes in Ca2+ concentration in nephron cells.
Kuz'min
O B
OB
Tarasov
S V
SV
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002301:Cardiac Glycosides / Q000494:pharmacology*; D004077:Digoxin / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D007668:Kidney / Q000098:blood supply / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D051381:Rats; D012079:Renal Circulation / Q000187:drug effects; D013328:Strophanthins / Q000494:pharmacology; D013997:Time Factors; D014700:Verapamil / Q000494:pharmacology*
D002301:Cardiac Glycosides; D013328:Strophanthins; D004077:Digoxin; D014700:Verapamil; D002118:Calcium
Vzaimodeĭstvie blokatora Ca2(+)-kanalov verapamila s serdechnymi glikozidami v pochke krysy.