Immunogenetics of cell surface antigens of human cancer.
Hybridoma technology, immunohistochemistry and molecular genetic techniques have paved the way for a general serological mapping of molecules expressed on the surface of normal and neoplastic cells. The emerging findings challenge cell lineage-based models of differentiation and point to new, modular concepts to explain complex tumor phenotypes. In parallel studies, the repertoire of T-cell recognized tumor antigens--still mysterious but probably quite distinct from the antibody-defined repertoire--has also become accessible to molecular analysis.
Rettig
W J
WJ
Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
D000951:Antigens, Neoplasm / Q000032:analysis / Q000235:genetics*; D000954:Antigens, Surface / Q000032:analysis / Q000235:genetics*; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000276:immunology*; D016201:Receptors, Lymphocyte Homing / Q000032:analysis / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D016201:Receptors, Lymphocyte Homing