Vascular action of natural vasopressin-like peptides in isolated rat tail artery.
The literature data regarding the vasoconstriction potency of natural vasopressin-like peptides are contradictory. The cumulative concentration-response curve for arginine-vasopressin (AVP), lysine-vasopressin (LVP), arginine-vasotocin (AVT), lysine-vasotocin (LVT) and phenypressin (PHP) on the isolated rat tail artery was determined. The potency rank of these peptides on the vascular smooth muscle of the rat tail artery was the following: AVP greater than LVP greater than AVT = LVT greater than PHP. The results are discussed in comparison to the data in the literature.
Okopień
B
B
Department of Pharmacology, Silesian Academy of Medicine, Katowice-Ligota, Poland.
Lubkowska
L
L
Grzonka
Z
Z
Trzeciak
H I
HI
D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives / Q000494:pharmacology; D007551:Isotonic Contraction; D008236:Lypressin / Q000494:pharmacology; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D014661:Vasoconstriction / Q000187:drug effects*; D014668:Vasotocin / Q000494:pharmacology
D001127:Arginine Vasopressin; C027289:argipressin, Phe(2)-; D008236:Lypressin; D014668:Vasotocin