title: In vitro susceptibilities of Borrelia burgdorferi to five oral cephalosporins and ceftriaxone.
abstract: We determined the in vitro susceptibilities of eight Borrelia burgdorferi isolates to five oral cephalosporins. MICs for B. burgdorferi 297 were 23 micrograms/ml (cephalexin), 45 micrograms/ml (cefadroxil), 91 micrograms/ml (cefaclor), 0.13 microgram/ml (cefuroxime), 0.8 microgram/ml (cefixime), and 0.02 microgram/ml (ceftriaxone). When B. burgdorferi isolates were exposed to concentrations twice the MIC of cefuroxime, cefixime, or ceftriaxone, at least 72 h of incubation was required to kill 99% of the organisms.
authors.affiliation: Microbiology Research Laboratory, Gundersen Medical Foundation, Las Crosse, Wisconsin 54601.
authors.forename: W A
authors.initials: WA
authors.lastname: Agger
authors.forename: S M
authors.initials: SM
authors.lastname: Callister
authors.forename: D A
authors.initials: DA
authors.lastname: Jobe
mesh_terms: D015748:Borrelia burgdorferi Group / Q000187:drug effects*; D002443:Ceftriaxone / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D006207:Half-Life; D006801:Humans; D008193:Lyme Disease / Q000382:microbiology
chemical_list: D002511:Cephalosporins; D002443:Ceftriaxone