Regulation of intracellular membrane transport.
A number of proteins that are necessary for membrane transport have been identified using cell-free assays and yeast genetics. Although our knowledge of transport mechanisms remains limited, common themes are clearly emerging. In particular, specific GTP-binding proteins appear to be involved, not only at all steps of membrane traffic but also at more than one check-point within each step. The ordered sequence of events occurring during vesicle formation, targeting and fusion may be regulated in a stepwise manner by specific GTP-dependent switches, which act as modular elements of the transport mechanism.
Gruenberg
J
J
European Molecular Biology Laboratory, Heidelberg, Germany.
Clague
M J
MJ
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology*; D006868:Hydrolysis; D007425:Intracellular Membranes / Q000378:metabolism*; D008081:Liposomes / Q000378:metabolism; D009711:Nucleotides / Q000378:metabolism; D009842:Oligopeptides / Q000502:physiology
D008081:Liposomes; D009711:Nucleotides; D009842:Oligopeptides; D019204:GTP-Binding Proteins