Design and synthesis of a C7 mimetic for the predicted gamma-turn conformation found in several constrained RGD antagonists.
Callahan
J F
JF
Department of Peptidomimetic Research, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406.
Bean
J W
JW
Burgess
J L
JL
Eggleston
D S
DS
Hwang
S M
SM
Kopple
K D
KD
Koster
P F
PF
Nichols
A
A
Peishoff
C E
CE
Samanen
J M
JM
D000595:Amino Acid Sequence; D015195:Drug Design; D005340:Fibrinogen / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry* / Q000378:metabolism; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D010975:Platelet Aggregation Inhibitors / Q000378:metabolism; D010980:Platelet Membrane Glycoproteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D011487:Protein Conformation
D009842:Oligopeptides; D010456:Peptides, Cyclic; D010975:Platelet Aggregation Inhibitors; D010980:Platelet Membrane Glycoproteins; C047981:arginyl-glycyl-aspartic acid; D005340:Fibrinogen