In vitro activity of meropenem and imipenem against mycobacteria: development of a daily antibiotic dosing schedule.
The activity of two carbapenem antibiotics, meropenem and imipenem, against Mycobacterium species was assessed by means of the Bactec 460 radiometric apparatus. This system allowed a result to be read in 4-10 days. The instability of imipenem, particularly, in the test system necessitated the development of a regimen of daily addition of antibiotic to permit a more accurate assessment of antibiotic activity to be made. When antibiotic-containing media are incubated for long periods, as is the case when determining antimycobacterial activity, the stability of test antibiotics is an important factor that must be considered.
Watt
B
B
Mycobacteria Unit, City Hospital, Edinburgh, UK.
Edwards
J R
JR
Rayner
A
A
Grindey
A J
AJ
Harris
G
G
D003470:Culture Media; D004355:Drug Stability; D015378:Imipenem / Q000494:pharmacology*; D066298:In Vitro Techniques; D000077731:Meropenem; D008826:Microbial Sensitivity Tests / Q000379:methods; D009161:Mycobacterium / Q000187:drug effects*; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009170:Nontuberculous Mycobacteria / Q000187:drug effects; D013845:Thienamycins / Q000494:pharmacology*
D003470:Culture Media; D013845:Thienamycins; D015378:Imipenem; D000077731:Meropenem