title: The role of the effective concentration in interpreting hemolysis data.
abstract: Problems inherent in traditional methods of determining the hemolytic activity of parenteral compounds are discussed. Data taken from a study which closely models the conditions present for an intravenous injection are re-examined. An equation is given which combines several variables into a single parameter, the effective concentration. A strong relationship is found between the effective concentration of the compound of interest and the hemolysis produced.
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, University of Arizona, Tucson.
authors.forename: G H
authors.initials: GH
authors.lastname: Ward
authors.forename: S H
authors.initials: SH
authors.lastname: Yalkowsky
mesh_terms: D004305:Dose-Response Relationship, Drug; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D019946:Propylene Glycol; D011409:Propylene Glycols / Q000494:pharmacology; D012996:Solutions
chemical_list: D011409:Propylene Glycols; D012996:Solutions; D019946:Propylene Glycol