title: Quantitative changes in the frequency and distribution of the C-cell population in the rat thyroid gland with age.
abstract: The development of calcitonin cells (C-cells) was investigated in rat thyroid glands from birth to 120 days, using an immunoperoxidase technique and a point-counting method. The proportion of C-cells to follicular cells was 4.5% on the day of birth and increased progressively to 10.4% by 120 days. The highest density of C-cells was noted in the mid-region of the lobes along a longitudinal axis. The caudal and cephalic regions of the lobes contained smaller numbers of C-cells. The C-cells tended to be more numerous in the posterior aspects of the lobes. Although the numbers of C-cells in 120-day-old animal were markedly increased as compared to animals at the time of birth, the cell distributions within the glands were similar at all ages.
authors.affiliation: Departamento de Citología e Histología Normal y Patológica, Facultad de Medicina, Universidad de Sevilla, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Martín-Lacave
authors.forename: E
authors.initials: E
authors.lastname: Conde
authors.forename: C
authors.initials: C
authors.lastname: Montero
authors.forename: H
authors.initials: H
authors.lastname: Galera-Davidson
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D002116:Calcitonin / Q000032:analysis*; D002452:Cell Count; D005260:Female; D008297:Male; D051381:Rats / Q000254:growth & development*; D017208:Rats, Wistar / Q000254:growth & development; D013961:Thyroid Gland / Q000166:cytology / Q000254:growth & development*
chemical_list: D002116:Calcitonin