Differences between vasorelaxant responses of the canine and human mesenteric arteries and veins to amrinone.
Amrinone induced similar degrees of relaxation in human mesenteric arteries and veins contracted with KCl, but exerted a more potent vasodilator effect in canine mesenteric veins than in arteries. Dibutyryl cAMP had a stronger effect on KCl-induced contraction in canine mesenteric veins than in arteries. These results suggest that amrinone promotes a different vasodilating action in human and canine mesenteric vessels, possibly via different sensitivity to cAMP in each vascular smooth muscle.
Itoh
H
H
Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
Sato
Y
Y
Taniguchi
K
K
Nakagawa
H
H
Inui
J
J
Takeuchi
J
J
D000676:Amrinone / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects*; D008642:Mesenteric Veins / Q000187:drug effects*; D013045:Species Specificity; D014664:Vasodilation / Q000187:drug effects*
D000676:Amrinone