title: Effects of subcutaneous versus intravenous administration of cyclosporin A on rat thymic histology and pharmacokinetics.
abstract: Cyclosporin A (CsA) was administered to rats by repeated subcutaneous (s.c.) or intravenous (i.v.) injections for 14 days. Changes in thymic histology were independent of the route of administration. Blood concentration--time profiles of CsA were similar at dose levels of i.v. 7.5 and s.c. 15 mg/kg/day, respectively. So, provided that the dose is reduced, i.v. injection can serve as an adequate alternative to s.c. injection, thereby preventing unwanted painful side-effects associated with the latter route of administration.
authors.affiliation: National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.
authors.forename: E J
authors.initials: EJ
authors.lastname: de Waal
authors.forename: H J
authors.initials: HJ
authors.lastname: Schuurman
authors.forename: C
authors.initials: C
authors.lastname: Hendriksen
authors.forename: B
authors.initials: B
authors.lastname: Elvers
authors.forename: A
authors.initials: A
authors.lastname: Van Dijk
authors.forename: H
authors.initials: H
authors.lastname: Van Loveren
mesh_terms: D000818:Animals; D016572:Cyclosporine / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008297:Male; D051381:Rats; D013950:Thymus Gland / Q000187:drug effects* / Q000473:pathology
chemical_list: D016572:Cyclosporine