Cyclosporin-induced nephrotoxicity and hypertension.
The use of cyclosporin in therapeutics is increasing. Unfortunately, cyclosporin has important detrimental effects on kidney function and blood pressure. Based on the pathogenesis of these side effects, different drug groups have been studied, but with variable success.
Sturrock
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ND
Department of Pharmacology and Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee.
Lang
C C
CC
Struthers
A D
AD
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003524:Cyclosporins / Q000009:adverse effects*; D004353:Drug Evaluation, Preclinical; D006801:Humans; D006973:Hypertension / Q000139:chemically induced* / Q000188:drug therapy / Q000453:epidemiology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000188:drug therapy / Q000453:epidemiology; D016595:Misoprostol / Q000627:therapeutic use
D000806:Angiotensin-Converting Enzyme Inhibitors; D002121:Calcium Channel Blockers; D003524:Cyclosporins; D016595:Misoprostol; D009320:Atrial Natriuretic Factor