[Synthesis of phosphono analogs of a phospholipid platelet activating factor].
Structural analogues of phospholipidic platelet activating factor, (2-acetoxy-3-octadecyloxy)propyl-1-phosphonocholine and (2-methoxy-3-octadecyloxy)propyl-1-phosphonocholine, were synthesized. High efficiency of the polymer-bound dibenzo-18-crown-6-ether as the O-alkylation catalyst was demonstrated. Reaction of allyl-octadecyl ether with methanol and iodine in the presence of zinc oxide was shown to give a mixture of 1-iodo-2-methoxy- and 1-methoxy-2-iodoprop-3-yl ethers of octadecanol in the 3:1 ratio.
Chuvilin
A N
AN
Trusov
V G
VG
Serebrennikova
G A
GA
D002247:Carbon Isotopes; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D009682:Magnetic Resonance Spectroscopy; D010742:Phospholipid Ethers / Q000138:chemical synthesis*; D010972:Platelet Activating Factor / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D013057:Spectrum Analysis
D002247:Carbon Isotopes; D010742:Phospholipid Ethers; D010972:Platelet Activating Factor; C077297:(2-acetoxy-3-octadecyloxy)propyl-1-phosphocholine; C077298:(2-methoxy-3-octadecyloxy)propyl-1-phosphocholine
Sintez fosfonoanalogov fosfolipidnogo faktora aktivatsii trombotsitov.