Glucocorticoid-induced DNA fragmentation: role of protein-kinase-C activity.
Glucocorticoid hormones (GCH) and IL-2 induce apoptotic cell death by a PKC-dependent mechanism. IL-4 counteracts apoptosis by inhibiting PKC activity. GCH and IL-2 show antagonistic effects on apoptosis when administered together. These data indicate that PKC activation in response to different stimuli can both enhance or reduce thymocyte survival.
Migliorati
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G
Istituto di Farmacologia Medica, Perugia University Medical School, Italy.
Pagliacci
M C
MC
D'Adamio
F
F
Crocicchio
F
F
Nicoletti
I
I
Riccardi
C
C
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D016923:Cell Death / Q000187:drug effects; D004247:DNA / Q000378:metabolism*; D003907:Dexamethasone / Q000494:pharmacology; D005434:Flow Cytometry; D005938:Glucocorticoids / Q000494:pharmacology*; D066298:In Vitro Techniques; D051379:Mice; D008809:Mice, Inbred C3H; D011493:Protein Kinase C / Q000378:metabolism*; D013601:T-Lymphocytes / Q000187:drug effects; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D005938:Glucocorticoids; D003907:Dexamethasone; D004247:DNA; D011493:Protein Kinase C; D013755:Tetradecanoylphorbol Acetate