[Dose-dependent effect of diltiazem on some lipid metabolic parameters in hemorrhagic shock in cats].
The possibility of modulating the phospholipid composition in the plasma membranes of hepatocytes and adipocytes by the calcium channel blocker diltiazem was studied on a model of hemorrhagic shock. Diltiazem injection facilitated normalization of phosphatidylinositol metabolism in the hepatocyte plasma membranes. Injection of a high dose of diltiazem was attended by a rise of the phosphatidylethanolamine level. Only low doses of diltiazem caused a normalizing effect on the phospholipid composition of adipocyte plasma membranes. A low dose of diltiazem caused a reduction in the content of very low density lipoproteins in venous blood, while a high dose reduced the content of low density lipoproteins.
Leskova
G F
GF
Udobichenko
V I
VI
Kalinina
M V
MV
D000818:Animals; D002415:Cats; D004110:Diltiazem / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D010743:Phospholipids / Q000378:metabolism*; D012771:Shock, Hemorrhagic / Q000188:drug therapy / Q000378:metabolism*
D010743:Phospholipids; D004110:Diltiazem
Dozozavisimoe vliianie diltiazema na nekotorye pokazateli lipidnogo obmena pri gemorragicheskom shoke.