title: [Differentiated thyroid carcinoma in childhood].
abstract: We report the cases of 6 patients, all younger than 14 years of age, with differentiated thyroid carcinoma. None of the patients had a previous history of radiation exposure. All patients presented with an enlarged thyroid gland as a solitary nodule, with or without cervical nodes. The fine-needle aspiration cytological examination was found to be the most sensitive and specific, evidencing 5 pure papillary adenocarcinoma and 1 follicular. Our standard preoperative evaluation included thyroid scintiscan and ultrasound examination, laboratory studies of thyroid function and serum calcitonin, chest x-ray, fine needle aspiration and vocal cord examination. The treatment was total thyroidectomy and bilateral modified neck dissection. A whole body scan (WBS) with 131I was performed 6 weeks after surgery, followed by radioiodine therapy for ablation of thyroid remnants and treatment of metastases when present. Patients then began thyroid replacement treatment. The follow-up of the patients consisted of thyroglobulin and WBS. The microscopic carcinoma was found in the contralateral lobe in 100%. Lung metastases were detected in 2 patients. All of the patients have survived during a follow-up period ranging from 6 to 108 months.
authors.affiliation: Servicio de Cirugía, Hospital Ramón y Cajal, Madrid.
authors.forename: M T
authors.initials: MT
authors.lastname: Visa Zueras
authors.forename: M
authors.initials: M
authors.lastname: Alonso Blanco
authors.forename: R
authors.initials: R
authors.lastname: Yturriaga Matarranz
authors.forename: P
authors.initials: P
authors.lastname: Ros Pérez
authors.forename: C
authors.initials: C
authors.lastname: Monroy Morante
authors.forename: J M
authors.initials: JM
authors.lastname: Sarriá Oses
authors.forename: R
authors.initials: R
authors.lastname: Barrio Castellanos
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D013965:Thyroidectomy; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D013974:Thyroxine
vernacular_title: Carcinoma diferenciado de tiroides en la edad pediátrica.