title: Multistep carcinogenesis: a 1992 perspective.
abstract: Cancer is the leading cause of death in Japan. Recent changes in cancer incidence patterns may reflect the trend toward a more Western diet and life-style. Among the dietary factors that contribute to carcinogenesis are the heterocyclic amines, a group of mutagenic compounds present in cooked meat and fish. Carcinogenesis is a multistep process in which cells accumulate multiple genetic alterations as they progress to a more malignant phenotype. Recognition of the growing number of interacting factors that contribute to carcinogenesis may force reconsideration of current methods of risk assessment.
authors.affiliation: National Cancer Center, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sugimura
mesh_terms: D000588:Amines / Q000009:adverse effects*; D002273:Carcinogens; D003043:Cocarcinogenesis; D004032:Diet / Q000009:adverse effects*; D006571:Heterocyclic Compounds / Q000009:adverse effects*; D006801:Humans; D007564:Japan; D009153:Mutagens; D009369:Neoplasms / Q000139:chemically induced / Q000209:etiology* / Q000628:therapy
chemical_list: D000588:Amines; D002273:Carcinogens; D006571:Heterocyclic Compounds; D009153:Mutagens