The effect of superoxide dismutase and reduced glutathione on cardiac performance after coronary occlusion and reperfusion--an experimental study in dogs.
To determine the effect of Superoxide Dismutase (SOD) and Reduced Glutathione (GSH) as free-radical scavengers on cardiac performance in the reperfusion period up to 60 minutes after occlusion of the Left Anterior Descending artery (LAD), 16 dogs were selected for study. In the 30th and 60th minutes of LAD occlusion and reperfusion periods Cardiac Output (CO), Heart Rate (HR), Mean Arterial Pressure (MAP), Pulmonary Capillary Wedge Pressure (PCWP), Coronary Perfusion Pressure (CPP), Rate Pressure Product (RPP) and Triple Index (TI) values were determined. Of the 16 dogs, 7 as controls and 7 treated with SOD and GSH could be included in the study, and 2 had to be excluded because of death. In the 30th and 60th minutes of reperfusion period, the treated dogs had higher CO and CPP (p less than 0.05, p less than 0.01 respectively), MAP values were different (p greater than 0.05, p less than 0.05 respectively) from controls, whereas lower HR (p less than 0.05, p greater than 0.05, respectively), RPP and TI values (p less than 0.05) were determined. It was concluded that the combination of SOD and GSH may improve cardiac performance in the reperfusion period.
Koçak
H
H
Department of Thoracic and Cardiovascular Surgery, Atatürk University Research Hospital, Erzurum, Turkey.
Yekeler
I
I
Başoğlu
A
A
Paç
M
M
Senocak
H
H
Yüksek
M S
MS
Ateş
A
A
Göksu
S
S
D000818:Animals; D016275:Atrial Function / Q000187:drug effects; D003250:Constriction; D004285:Dogs; D016166:Free Radical Scavengers; D005978:Glutathione / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D015425:Myocardial Reperfusion; D013482:Superoxide Dismutase / Q000494:pharmacology*; D016276:Ventricular Function / Q000187:drug effects*
D016166:Free Radical Scavengers; D013482:Superoxide Dismutase; D005978:Glutathione