[Mechanism of prolonged hypocoagulation appearing after intratracheal administration of heparin].
The comparative study of intratracheal and intravenous effect of administration of heparin on blood clotting and mast cell population condition was carried out in experiments. Unlike intravenous bolus injection of heparin, which induced fast short-time inactivation of all enzyme clotting factors, a single intratracheal injection inactivated "internal" rout of thrombin production. It was shown, that long-term hypocoagulability effect and inhibition of factors of blood coagulation after intratracheal administration of heparin correlated with accumulation of heparin in mast cell.
Efimov
V S
VS
Rumiantseva
A G
AG
Golovleva
O A
OA
Rozkin
M Ia
MIa
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001779:Blood Coagulation Factors / Q000032:analysis; D001780:Blood Coagulation Tests; D006493:Heparin / Q000008:administration & dosage* / Q000097:blood / Q000494:pharmacology; D007267:Injections; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D013916:Thrombelastography; D014132:Trachea
D001779:Blood Coagulation Factors; D006493:Heparin
Mekhanizm prolongirovannoĭ gipokoaguliatsii, voznikaiushcheĭ pri intratrakheal'nom vvedenii geparina.