title: [Preparation of water-soluble hydronaphthoquinone derivatives and its application to the determination of hydrogen peroxide in clinical chemistry].
abstract: Several 1-alkoxy-2,3-dichloro-4-hydroxynaphthalene derivatives were prepared. These compounds were oxidized by hydrogen peroxide in the presence of a peroxidase to give 2,3-dichloro-1,4-naphthoquinone, which then reacted with various alkyl benzoylacetates to develop blue coloration with absorption maximum at greater than 600 nm. The color development reaction can be applied to the determination of appropriate serum constituents such as cholesterol.
authors.affiliation: Kyoto Pharmaceutical University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ohta
authors.forename: S
authors.initials: S
authors.lastname: Hatakeyama
authors.forename: C
authors.initials: C
authors.lastname: Aono
authors.forename: T
authors.initials: T
authors.lastname: Koike
authors.forename: I
authors.initials: I
authors.lastname: Tanimizu
authors.forename: H
authors.initials: H
authors.lastname: Hirakawa
mesh_terms: D003116:Color; D006861:Hydrogen Peroxide / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D009284:Naphthols / Q000737:chemistry*; D009285:Naphthoquinones / Q000737:chemistry; D012996:Solutions; D013055:Spectrophotometry, Infrared
chemical_list: D009284:Naphthols; D009285:Naphthoquinones; D012996:Solutions; D006861:Hydrogen Peroxide; C007332:dichlone