Acute secretory travellers' diarrhoea caused by Vibrio cholerae non-01 which does not produce cholera-like or heat-stable enterotoxins.
An Australian tourist suffering from severe acute watery diarrhoea and dehydration due to Vibrio cholerae non-01 was studied. The V. cholerae strain isolated from the patient belonged to serovar 05. The organism did not produce any of the conventional enterotoxins including cholera-toxin (CT) or heat-stable toxins (NAG-ST) that are known to be associated with intestinal secretion. This report suggests that toxin(s) other than CT-like or NAG-ST may be involved in the pathogenesis of diarrhoea by some V. cholerae non-01 strains.
Bhattacharya
S K
SK
National Institute of Cholera and Enteric Diseases, Beliaghata, Calcutta, India.
Bhattacharya
M K
MK
Ramamurthy
T
T
Pal
A
A
Bag
P K
PK
Takeda
T
T
Shimada
T
T
Dutta
P
P
Debnath
A
A
Chakraborti
S
S
D000208:Acute Disease; D000328:Adult; D002771:Cholera / Q000382:microbiology*; D002772:Cholera Toxin / Q000096:biosynthesis*; D003967:Diarrhea / Q000382:microbiology*; D004768:Enterotoxins / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D014195:Travel; D014734:Vibrio cholerae / Q000378:metabolism*
D004768:Enterotoxins; C037420:stN protein, Vibrio cholerae; D002772:Cholera Toxin