Naloxone or haloperidol but not yohimbine reverse apomorphine-induced respiratory depression.
Intravenous injection of low doses of naloxone was found to reverse the respiratory depression induced by apomorphine in chloralose-anesthesized dogs. Similar results were obtained with haloperidol, whereas yohimbine remained ineffective. These data suggest that apomorphine depresses respiratory rate through a mechanism involving both dopamine and opiate mechanisms but not alpha 2-adrenoceptors. Respiratory arrest induced by overdosages of apomorphine can be treated with naloxone.
Montastruc
J L
JL
Laboratoire de Pharmacologie Médicale et Clinique, INSERM U317, Faculté de Médecine, Toulouse, France.
Rascol
O
O
Montastruc
P
P
D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors* / Q000633:toxicity; D004285:Dogs; D004347:Drug Interactions; D005260:Female; D006220:Haloperidol / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D012131:Respiratory Insufficiency / Q000139:chemically induced / Q000188:drug therapy*; D014839:Vomiting / Q000139:chemically induced; D015016:Yohimbine / Q000494:pharmacology*
D015016:Yohimbine; D009270:Naloxone; D006220:Haloperidol; D001058:Apomorphine