Effect of drug therapy on the relapse of peptic ulcers. 1st communication: the effect of acute therapy.
The following study was conducted in order to investigate the effect of drug therapy on the relapse of peptic ulcers. Acute therapy with pirenzepine (Gastrozepin, CAS 28797-61-7) (100 mg/d) or cimetidine (CAS 51481-61-9) (800 mg/d) was given to 402 patients with peptic ulcers using the envelope method. Subsequently, 1-year maintenance therapy with pirenzepine (75 mg/d) or placebo was carried out in a double-blind study in 251 patients who had been cured within 3 months. During the study period, an endoscopic examination was repeated regularly to study the relapse of ulcers. When the results were stratified and analyzed by Cutler-Ederer's life table method to see changes in relapse over time, it was noted that the acute therapy for active ulcers did have an influence on the course of relapse after the ulcer lesions had been cured. Pirenzepine, a M1 antagonist, was superior to cimetidine, a H2 antagonist, in the prevention of relapse of ulcers after they had been cured. The results suggest that the prevention of relapse of peptic ulcers should be started at the stage of acute therapy for active ulcers and that care should be taken in selecting drugs. The results also suggest that the natural history of peptic ulcers with respect to their relapse can be modified to a certain extent by drug therapy although the period for such cannot be specified.
Ishimori
A
A
Department of Clinical and Laboratory Medicine, Tohoku University School of Medicine, Sendai, Japan.
Kawamura
T
T
Koizumi
F
F
D002927:Cimetidine / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D010437:Peptic Ulcer / Q000188:drug therapy*; D010890:Pirenzepine / Q000009:adverse effects / Q000627:therapeutic use*; D012008:Recurrence; D013276:Stomach Ulcer / Q000517:prevention & control
D010890:Pirenzepine; D002927:Cimetidine