title: Insulin and growth factors adaptation to normal puberty.
abstract: Insulin and IGF-1 production were measured throughout childhood and puberty and into adult life. Basal insulin and IGF-1 secretion increased during puberty, falling back to prepubertal levels in adulthood. However, fasting glucose levels remained constant, implying an increase in tissue resistance to insulin coinciding with puberty.
authors.affiliation: Department of Endocrinology, St. Bartholomew's Hospital, London, UK.
authors.forename: M O
authors.initials: MO
authors.lastname: Savage
authors.forename: C P
authors.initials: CP
authors.lastname: Smith
authors.forename: D B
authors.initials: DB
authors.lastname: Dunger
authors.forename: E A
authors.initials: EA
authors.lastname: Gale
authors.forename: J M
authors.initials: JM
authors.lastname: Holly
authors.forename: M A
authors.initials: MA
authors.lastname: Preece
mesh_terms: D000222:Adaptation, Physiological; D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood* / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology; D000078790:Insulin Secretion; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis* / Q000378:metabolism; D008297:Male; D011627:Puberty / Q000502:physiology*; D012016:Reference Values
chemical_list: D001786:Blood Glucose; D007328:Insulin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone