Amyloidogenesis in Alzheimer's disease: basic biology and animal models.
A principal neuropathological hallmark of Alzheimer's disease is deposition of beta-amyloid, composed primarily of a 4 kD peptide, A beta. This peptide is derived from larger amyloid precursor proteins. The mechanisms that are responsible for A beta formation in vivo are unknown. Recently, transgenic strategies have been employed to test several hypothetical mechanisms in order to reproduce Alzheimer's disease-specific pathology in rodents.
Sisodia
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Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Price
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D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D000682:Amyloid / Q000096:biosynthesis*; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans
D000682:Amyloid