Immobilized proteins as chromatographic supports for chiral resolution.
This review examines the role of protein-bonded chiral stationary phases (CSPs) in enantiomeric separation and investigates the performance characteristics and desired properties of protein CSPs for separation and large-scale operation. The review also discusses the ability of protein-based CSPs to examine the stereochemistry of drug metabolism processes.
Narayanan
S R
SR
Biochemical Research Laboratory, University of Kansas, Lawrence 66045.
D000818:Animals; D002845:Chromatography / Q000379:methods*; D006801:Humans; D009961:Orosomucoid / Q000737:chemistry; D010059:Ovomucin / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*; D012709:Serum Albumin / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry; D013237:Stereoisomerism; D014361:Trypsin Inhibitors / Q000737:chemistry
D009961:Orosomucoid; D011506:Proteins; D012709:Serum Albumin; D014361:Trypsin Inhibitors; D012710:Serum Albumin, Bovine; D010059:Ovomucin