Successful T cell-depleted allogeneic bone marrow transplantation in a child with recurrent multiple extramedullary plasmacytomas.
Multiple plasmacytomas with IgA paraproteinemia, a low grade lymphoid neoplasm of differentiated B cells rarely seen in the young, were encountered in a 10-year-old child. T cell-depleted allogeneic bone marrow transplantation (BMT) was performed because of progressive disease despite chemotherapy. Donor T cells were infused after transplantation in gradually increasing numbers to achieve a graft-versus-tumor effect. Complete eradication of all tumor masses was achieved following BMT with normalization of serum immunoglobulin levels. The patient remains in complete remission 4 years after BMT. Allogeneic BMT should be considered early in the course of low-grade lymphoid malignancy in the younger age group.
Or
R
R
Department of Bone Marrow Transplantation, Hadassah University Hospital, Jerusalem, Israel.
Mehta
J
J
Naparstek
E
E
Okon
E
E
Cividalli
G
G
Slavin
S
S
D016026:Bone Marrow Transplantation / Q000276:immunology; D002648:Child; D005260:Female; D006087:Graft vs Host Reaction / Q000276:immunology; D006801:Humans; D008212:Lymphocyte Depletion; D009101:Multiple Myeloma / Q000601:surgery*; D012008:Recurrence; D013601:T-Lymphocytes / Q000276:immunology / Q000637:transplantation; D014184:Transplantation, Homologous