[Activity of antioxidant protection enzymes and content of lipid peroxidation products in blood serum and cerebrospinal fluid in patients with ischemic brain disease].
Activity of superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase as well as content of diene conjugates and malonic dialdehyde were studied in blood serum and cerebrospinal fluid of patients with transitory ischemia, small ischemic insult, ischemic insult of middle severity and with severe ischemic insult without lethality within 1-2, 7-8 and 14-15 days of diseases. Content of lipid peroxidation products and activity of antioxidant enzymes were decreased in the biological fluids studied in all the forms of brain circulation impairments within early periods of pathology. These patterns tend to normalization within 14-15 days. The rate of biochemical alterations corresponded highly to severity of impairments developed and these patterns may be used for diagnostic and prognostic purposes.
Dzhandzhgava
T G
TG
Shakarishivili
R R
RR
D002545:Brain Ischemia / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D002374:Catalase / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D005980:Glutathione Reductase / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D006801:Humans; D002546:Ischemic Attack, Transient / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood; D013482:Superoxide Dismutase / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*
D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase
Aktivnost' fermentov antiokislitel'noĭ zashchity i soderzhanie produktov perekisnogo okisleneniia lipidov v syvorotke krovi i tserebrospinal'noĭ zhidkosti bol'nykh ishemicheskoĭ boleznĭu mozga.