title: Nonlinearity of amoxicillin absorption kinetics in human.
abstract: Specialised gastrointestinal absorption of amoxicillin has been suggested in man and has been demonstrated in animals. In order to study the rate and extent of amoxicillin absorption, six healthy subjects were given 500 mg IV and two oral doses (500 mg and 3 g as a suspension). Absorption kinetics was analysed by compartmental modelling, noncompartmental methods and by calculation of absorption rates using deconvolution. Dose-dependency of the extent of amoxicillin absorption was observed, with a lower than expected mean maximum plasma concentration (49%), and fraction of the dose absorbed (39%) after the 3 g dose calculated from the 500 mg dose, assuming kinetic linearity. Zero-order kinetics of absorption was apparent in some subjects after the 500 mg dose, both from model fitting and absorption rate profile. However, no pattern consistent with pure first-order or zero-order absorption was observed after both oral doses in any individual. The dose-dependency of amoxicillin absorption was confirmed by a trend to an increased time of absorption for the high dose. The results show the variable nature and nonlinearity of the gastrointestinal absorption of amoxicillin and indicate the involvement of a number of factors, in addition to simple diffusion.
authors.affiliation: Department of Clinical Pharmacology, Karolinska Institute, Huddinge University Hospital, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Paintaud
authors.forename: G
authors.initials: G
authors.lastname: Alván
authors.forename: M L
authors.initials: ML
authors.lastname: Dahl
authors.forename: A
authors.initials: A
authors.lastname: Grahnén
authors.forename: J
authors.initials: J
authors.lastname: Sjövall
authors.forename: J O
authors.initials: JO
authors.lastname: Svensson
mesh_terms: D000658:Amoxicillin / Q000097:blood / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008954:Models, Biological
chemical_list: D000658:Amoxicillin