[The effect of dibunol on lipid peroxidation and the alpha-tocopherol level in the lungs of rats with acute blood loss].
Experiments on linear male rats were made to study the pathophysiological mechanism of the synthetic antioxidant dibunol on the levels of primary and end products of lipid peroxidation (LPO) and of alpha-tocopherol (TP) in the lungs in acute hemorrhage. Dibunol in a dose of 120 mg/kg injected 5 min after the hemorrhage inhibited LPO to the level in intact animals and raised the content of TP to the level seen in operated animals without any hemorrhage. The conclusion is drawn about a possibility of using dibunol for correction of disturbed pulmonary metabolism in urgent conditions associated with blood loss.
Matveev
S B
SB
Marchenko
V V
VV
Golikov
P P
PP
D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use*; D006470:Hemorrhage / Q000188:drug therapy* / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000032:analysis; D008168:Lung / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014810:Vitamin E / Q000032:analysis / Q000378:metabolism*
D000975:Antioxidants; D008055:Lipids; D014810:Vitamin E; D002084:Butylated Hydroxytoluene
Vliianie dibunola na perekisnoe okislenie lipidov i uroven' al'fa-tokoferola v legkikh krys pri ostroĭ krovopotere.