Survival following hydrofluoric acid ingestion.
Systemic toxicity after significant dermal exposure to hydrofluoric acid includes rapid development of hypocalcemia and hyperkalemia, leading to ventricular fibrillation. Similar dysrhythmias have occurred in patients after ingestion of sodium fluoride-containing compounds. Ingestion of hydrofluoric acid could induce similar cardiac toxicity; however, reported cases of hydrofluoric acid ingestion rarely have been described, and the rapid death of these patients has not allowed verification of this hypothesis. On two separate occasions, a 70-year-old woman ingested up to 2 oz of a 8% hydrofluoric acid-containing solution. Recurrent ventricular fibrillation with concurrent hypocalcemia and hypomagnesemia complicated her first episode, whereas a more aggressive administration of calcium and magnesium may have prevented dysrhythmias in the second episode. Survival from ventricular fibrillation after hydrofluoric acid ingestion has not been reported previously and suggests a role for aggressive empiric calcium and magnesium replacement.
Stremski
E S
ES
Department of Emergency Medicine, Hennepin County Medical Center, Minneapolis, Minnesota.
Grande
G A
GA
Ling
L J
LJ
D000368:Aged; D002125:Calcium Gluconate / Q000627:therapeutic use; D004554:Electric Countershock; D005260:Female; D006801:Humans; D006858:Hydrofluoric Acid / Q000506:poisoning*; D006996:Hypocalcemia / Q000139:chemically induced* / Q000188:drug therapy; D008275:Magnesium Deficiency / Q000139:chemically induced* / Q000188:drug therapy; D008278:Magnesium Sulfate / Q000627:therapeutic use; D014693:Ventricular Fibrillation / Q000139:chemically induced* / Q000628:therapy
D008278:Magnesium Sulfate; D006858:Hydrofluoric Acid; D002125:Calcium Gluconate