title: Contact sensitivity to flavourings and perfumes in atopic dermatitis.
abstract: 16 children with atopic dermatitis and 4 nonatopics were skin tested with flavourings and perfumes. Immediate reactions to balsam of Peru and fragrance-mix were found in 9 atopics, and none among nonatopics. An irritant is more probable than an immunologic mechanism. Allergen solutions should probably be assayed at a lower concentration in atopic patients. This study points to a possible aggravating factor from perfumes and flavourings ingested, inhaled, or used as cosmetics.
authors.affiliation: Service de Dermatologie, Hôpital des Enfants, Bordeaux, France.
authors.forename: R
authors.initials: R
authors.lastname: Abifadel
authors.forename: P
authors.initials: P
authors.lastname: Mortureux
authors.forename: M
authors.initials: M
authors.lastname: Perromat
authors.forename: G
authors.initials: G
authors.lastname: Ducombs
authors.forename: A
authors.initials: A
authors.lastname: Taieb
mesh_terms: D002648:Child; D003876:Dermatitis, Atopic / Q000150:complications*; D003877:Dermatitis, Contact / Q000209:etiology*; D017453:Dermatitis, Irritant / Q000209:etiology; D005148:Facial Dermatoses / Q000139:chemically induced; D005260:Female; D005421:Flavoring Agents / Q000009:adverse effects*; D006801:Humans; D008297:Male; D010476:Perfume / Q000009:adverse effects*
chemical_list: D005421:Flavoring Agents; D010476:Perfume