Circulating levels of endothelin and atrial natriuretic factor during postnatal life.
We determined plasma endothelin-1-like immunoreactivity and atrial natriuretic factor concentrations in preterm and full-term newborn infants during the first month of life. Plasma endothelin-1-like immunoreactivity levels were far greater than those of maternal blood in the newborn infants. The highest plasma endothelin-1-like immunoreactivity levels were observed on the first day of life (8.7 +/- 3.7 pmol/l) and gradually decreased with age. There was no significant difference in plasma endothelin-1-like immunoreactivity levels between preterm and full-term infants. A good correlation was observed between plasma endothelin-1-like immunoreactivity levels and atrial natriuretic factor concentrations (p < 0.01). These results suggest that circulating endothelin may regulate the cardiovascular system in the newborn period.
Kojima
T
T
Department of Pediatrics, Kansai Medical University, Osaka, Japan.
Isozaki-Fukuda
Y
Y
Takedatsu
M
M
Hirata
Y
Y
Kobayashi
Y
Y
D009320:Atrial Natriuretic Factor / Q000097:blood*; D016232:Endothelins / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D007234:Infant, Premature / Q000097:blood*
D016232:Endothelins; D009320:Atrial Natriuretic Factor