title: Carbonic anhydrase inhibitors. V: Pyrylium salts in the synthesis of isozyme-specific inhibitors.
abstract: Syntheses and physicochemical properties of 2,4,6-tri-, 2,3,4,6-tetra-, or 2,3,4,5,6-pentasubstituted 1-(2-sulfonamido-1,3,4-thiadiazol-5-yl)pyridinium perchlorates are presented. The new compounds, putative inhibitors of membrane-bound carbonic anhydrase, were tested for inhibitory action on the bovine red cell enzyme.
authors.affiliation: Department of Organic Chemistry, University of Bucharest, Romania.
authors.forename: C T
authors.initials: CT
authors.lastname: Supuran
authors.forename: G
authors.initials: G
authors.lastname: Manole
authors.forename: A
authors.initials: A
authors.lastname: Dinculescu
authors.forename: A
authors.initials: A
authors.lastname: Schiketanz
authors.forename: M D
authors.initials: MD
authors.lastname: Gheorghiu
authors.forename: I
authors.initials: I
authors.lastname: Puscas
authors.forename: A T
authors.initials: AT
authors.lastname: Balaban
mesh_terms: D002257:Carbonic Anhydrase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D007527:Isoenzymes; D009682:Magnetic Resonance Spectroscopy; D011726:Pyridinium Compounds / Q000138:chemical synthesis*; D013830:Thiadiazoles / Q000138:chemical synthesis*
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D007527:Isoenzymes; D011726:Pyridinium Compounds; D013830:Thiadiazoles