[Toxic effects of heavy metal salts on intact and irradiated cultured mammalian cells].
The toxicity of solutions of K2Cr2O7 and NiSO4.8H2O for cultivated Chinese hamster fibroblasts and murine lymphoma Sp-2 cells was determined using three criteria of damage: cell death (dyeing with trypan blue), inhibition of cell proliferation and their colony-forming activity. It was shown that both salts have equal toxicity in (10(-3)-10(-2)) M interval for both culture investigated relative to inhibition of cell proliferation. The threshold of toxicity of K2Cr2O7 relative to reproductive cell death (10(-4) M is smaller than to the inhibition of cell proliferation. The nontoxic concentration of K2Cr2O7 enhanced the radiation-induced reproductive death of fibroblast culture at doses 2 and 4 Gy.
Ershov
Iu A
IuA
Kublik
L N
LN
Pleteneva
T V
TV
Eĭdus
L Kh
LKh
D000818:Animals; D016923:Cell Death; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D005347:Fibroblasts / Q000187:drug effects* / Q000528:radiation effects*; D008223:Lymphoma; D008670:Metals / Q000633:toxicity*; D051379:Mice; D011829:Radiation Dosage; D012492:Salts / Q000633:toxicity; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000528:radiation effects*
D008670:Metals; D012492:Salts
Toksicheskoe deĭstvie soleĭ tiazhelykh metallov na intaktnye i obluchennye kul'tiviruemye kletki mlekopitaiushchikh.