title: Amnesia by post-training infusion of glutamate receptor antagonists into the amygdala, hippocampus, and entorhinal cortex.
abstract: The blockers of glutamate receptors, aminophosphonovaleric acid (AP5) (5.0 micrograms) and cyano-nitroquinoxaline-dione (CNQX) (0.5 microgram), were infused bilaterally into the amygdala, dorsal hippocampus, or entorhinal cortex of rats through indwelling cannulae 0, 90, 180, or 360 min after step-down inhibitory avoidance training. Animals were tested for retention 24 h after training. In the amygdala or hippocampus, AP5 was amnestic when given 0 min after training and CNQX was amnestic when given 0, 90, or 180 min after training. In the entorhinal cortex, AP5 was amnestic when given 90 or 180 min after training and CNQX had no effect. The results suggest that a phenomenon sensitive first to AP5 and then to CNQX in the amygdala and hippocampus, probably long-term potentiation (LTP), is crucial to post-training memory processing. LTP in these two structures could underlie their role in memory consolidation and could explain the late involvement of the entorhinal cortex in post-training memory processing.
authors.affiliation: Departamento de Bioquimica, UFRGS (centro), Porto Alegre, RS, Brazil.
authors.forename: D
authors.initials: D
authors.lastname: Jerusalinsky
authors.forename: M B
authors.initials: MB
authors.lastname: Ferreira
authors.forename: R
authors.initials: R
authors.lastname: Walz
authors.forename: R C
authors.initials: RC
authors.lastname: Da Silva
authors.forename: M
authors.initials: M
authors.lastname: Bianchin
authors.forename: A C
authors.initials: AC
authors.lastname: Ruschel
authors.forename: M S
authors.initials: MS
authors.lastname: Zanatta
authors.forename: J H
authors.initials: JH
authors.lastname: Medina
authors.forename: I
authors.initials: I
authors.lastname: Izquierdo
mesh_terms: D000648:Amnesia, Retrograde / Q000139:chemically induced*; D000679:Amygdala / Q000187:drug effects* / Q000601:surgery; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D004357:Drug Synergism; D005971:Glutamates; D006624:Hippocampus / Q000187:drug effects* / Q000601:surgery; D015918:Infusion Pumps, Implantable; D008297:Male; D008568:Memory; D016202:N-Methylaspartate; D051381:Rats; D012153:Retention, Psychology / Q000187:drug effects
chemical_list: D005971:Glutamates; D016202:N-Methylaspartate