title: [Death in Horton disease. Prognostic factors].
abstract: The authors reported causes of death and searched for prognosis factors in Giant Cell Arteritis (GCA). The diagnosis was confirmed by temporal biopsy in all cases. Fourteen patients died during treatment; thirty-six patients had completely recovered (follow up > 6 months after withdrawal of steroid therapy). The commonest causes of death were cardiovascular (n = 7) and digestive (n = 4); they occurred after an average of 195 days of treatment, half of them during the first three months. One death was due to GCA (autopsy) and five deaths were attributed to the treatment with corticosteroids. The prognosis factors were searched for by comparing age, sex, clinical signs, laboratory data before treatment, past medical history in the both series; further more initial dose of Prednisone and the dose after 180 days of steroid therapy were compared in the two groups. The adverse prognosis factors revealed by this study were: advanced age (p < 0.01), previous ischaemic heart disease (p < 0.05) and higher dose of corticosteroids administered at 6 months of treatment (< 0.01).
authors.affiliation: Service de Médecine Interne, CHU, Limoges.
authors.forename: F
authors.initials: F
authors.lastname: Liozon
authors.forename: E
authors.initials: E
authors.lastname: Vidal
authors.forename: F
authors.initials: F
authors.lastname: Gaches
authors.forename: J
authors.initials: J
authors.lastname: Venot
authors.forename: E
authors.initials: E
authors.lastname: Liozon
authors.forename: M
authors.initials: M
authors.lastname: Cransac
authors.forename: V
authors.initials: V
authors.lastname: Loustaud
authors.forename: J F
authors.initials: JF
authors.lastname: Berdah
mesh_terms: D000206:Actuarial Analysis; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000367:Age Factors; D002318:Cardiovascular Diseases / Q000150:complications; D002423:Cause of Death; D013700:Giant Cell Arteritis / Q000150:complications / Q000188:drug therapy / Q000401:mortality*; D006801:Humans; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D000305:Adrenal Cortex Hormones
vernacular_title: Les décès dans la maladie de Horton. Facteurs de pronostic.