title: The spectrum of Pneumocystis carinii infection after liver transplantation in children.
abstract: We report the experience with Pneumocystis carinii lung infections in the 109 children undergoing liver transplantation at our hospital between August, 1985 and May, 1989. PCP developed in 9 of the 86 patients (10%) surviving > or = 6 weeks after transplantation and not receiving P carinii chemoprophylaxis. Of the 59 patients undergoing BAL 2 or more weeks after transplantation there were 16 specimens from 14 patients (24%) positive for P carinii. These patients had a spectrum of illness ranging from asymptomatic to severe pneumonia requiring mechanical ventilation. The mean interval from first transplantation to bronchoalveolar lavage positive for P carinii was 24.9 weeks and the mean interval to first PCP was 28.0 weeks. The earliest and latest occurrences of PCP were 7 weeks and 73 weeks, respectively, after transplantation. There were no complications attributed to BAL.
authors.affiliation: Department of Pediatrics, University of Nebraska Medical Center, Omaha 68198.
authors.forename: J L
authors.initials: JL
authors.lastname: Colombo
authors.forename: P H
authors.initials: PH
authors.lastname: Sammut
authors.forename: A N
authors.initials: AN
authors.lastname: Langnas
authors.forename: B W
authors.initials: BW
authors.lastname: Shaw
mesh_terms: D000293:Adolescent; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016031:Liver Transplantation / Q000009:adverse effects*; D011010:Pneumocystis / Q000302:isolation & purification; D011020:Pneumonia, Pneumocystis / Q000209:etiology* / Q000628:therapy