Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities.
Reveromycins A, B, C and D showed inhibitory activity against EGF-stimulated mitogen response in Balb/MK cells. Furthermore reveromycins A, C and D exhibited morphological reversion of srcts-NRK cells, antiproliferative activity against human tumor cell lines and antifungal activity. The effects of reveromycins A, C and D on eukaryotic cells were closely similar to each other, but those of reveromycin B were very weak. In vitro studies revealed that reveromycin A is a selective inhibitor of protein synthesis in eukaryotic cells.
Takahashi
H
H
Antibiotics Laboratory, RIKEN, Institute of Physical and Chemical Research, Saitama, Japan.
Osada
H
H
Koshino
H
H
Sasaki
M
M
Onose
R
R
Nakakoshi
M
M
Yoshihama
M
M
Isono
K
K
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004815:Epidermal Growth Factor / Q000037:antagonists & inhibitors*; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests; D011714:Pyrans / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D013141:Spiro Compounds / Q000494:pharmacology*; D013936:Thymidine / Q000378:metabolism; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014764:Viral Proteins / Q000096:biosynthesis
D000900:Anti-Bacterial Agents; D011714:Pyrans; D013141:Spiro Compounds; D014764:Viral Proteins; C068098:reveromycin A; D004815:Epidermal Growth Factor; D013936:Thymidine