[Mechanisms of hepatoprotective action of new nicotinic acid derivatives in experimental CCL4-induced liver injury].
New biologically active compounds (BAC) created on the basis of nicotinic acid possess hepatoprotective action. The preparations were introduced preventively in doses of 10 mg/kg during 14 days. Litonit and nicogamol increased survival of experimental animals by 36.8% and nicotinic acid by 26.8%. ALT, AST, GGT activity in the blood serum was reduced. The activity of the main antioxidant enzymes (SOD and catalase) grew in the rat liver tissue in parallel with inhibition of DK and MDA activity. Morphological picture of the rat liver, most evident after application of litonit improved. Hepatoprotective action of these BAC are attributed to their membrano stabilizing effects.
Strechen'
S B
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Kresiun
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D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy* / Q000401:mortality; D002374:Catalase / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008107:Liver Diseases / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D009539:Nicotinic Acids / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D013997:Time Factors
D009539:Nicotinic Acids; C041554:litonit; C041555:nikogamol; D002374:Catalase; D013482:Superoxide Dismutase
Mekhanizmy gepatoprotektornogo deĭstviia novykh proizvodnykh nikotinovoĭ kisloty pri éksperimental'nom porazhenii pecheni chetyrekhkhloristym uglerodom.