[The effect of gamma irradiation at sub- and supralethal doses on the lipid composition of the mucosa and of the brush border membrane of the small intestine in rats].
A study was made of the amount of cholesterol and its ethers (phosphatidyl choline, phosphatidyl ethanolamine, sphingomyelin, phosphatidyl serine, and phosphatidyl inositol) in mucosa and membrane of the small intestine brush border 24 h after 4 Gy and 2 h after 20 Gy irradiation. No changes in the lipid content of mucosa and membrane of the brush border were noted after 4 Gy irradiation. Exposure to 20 Gy radiation doubled the number of cholesterol ethers and made the number of individual phospholipids and cholesterol increase by nearly 1.5 times. The amount of phosphatidyl serine in the brush border membrane increased by almost 3 times; the concentration of other lipids increased by nearly 1.5 times; cholesterol/phospholipid ratio was unchangeable.
Potekhina
N I
NI
Kolomiĭtseva
I K
IK
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D007413:Intestinal Mucosa / Q000737:chemistry / Q000528:radiation effects* / Q000648:ultrastructure; D007421:Intestine, Small / Q000737:chemistry / Q000528:radiation effects* / Q000648:ultrastructure; D008563:Membrane Lipids / Q000032:analysis / Q000528:radiation effects*; D008871:Microvilli / Q000737:chemistry / Q000528:radiation effects; D051381:Rats; D013997:Time Factors
D008563:Membrane Lipids
Vliianie gamma-oblucheniia v sub- i sverkhletal'noĭ dozakh na lipidnyĭ sostav slizistoĭ obolochki i membrany shchetochnoĭ kaemki tonkogo kishechnika krys.