Molecular characterization of "inverted" pericentromeric heterochromatin of chromosome 3.
Inversion of the pericentromeric region of human chromosome 3 [inv (3) (p11q11.2)] is a rare event. Initially, this inversion was identified with staining for Q-bands by fluorescence using quinacrine (QFQ) and later characterized with staining for C-bands by CBG technique. The molecular methods of fluorescence in situ hybridization (FISH) and AluI/Giemsa and TaqI/Giemsa techniques were utilized. The findings suggest that the variable band q11.2 on chromosome 3 contains alphoid DNA sequences, which appear to be similar to those identified by conventional methods in the centromeric region (band p11).
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Division of Genetics, Long Island College Hospital, SUNY Health Science Center, Brooklyn 11201.
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Verma
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D000293:Adolescent; D002503:Centromere / Q000737:chemistry*; D002871:Chromosome Banding; D002893:Chromosomes, Human, Pair 3 / Q000737:chemistry* / Q000502:physiology; D004247:DNA / Q000235:genetics; D006570:Heterochromatin / Q000737:chemistry*; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics
D006570:Heterochromatin; D004247:DNA