title: Use of gene therapy to correct elevated LDL levels in LDL-receptor deficient rabbits.
abstract: Recent studies using gene therapy to correct low-density lipoprotein (LDL)-receptor deficiency in rabbits suggest that practical applications of such techniques may be forthcoming. While complete correction of elevated serum cholesterol levels resulting from LDL-receptor deficiency is not yet possible, significant reductions were possible following gene therapy.
mesh_terms: D000818:Animals; D015316:Genetic Therapy; D006949:Hyperlipidemias / Q000235:genetics / Q000628:therapy*; D008077:Lipoproteins, LDL / Q000097:blood; D011817:Rabbits; D011973:Receptors, LDL / Q000235:genetics*
chemical_list: D008077:Lipoproteins, LDL; D011973:Receptors, LDL