[Metabolic effects of experimental thermal damage of the brain in rats--cold lesion].
Experimental thermal brain injury leads to significant reduction of glucose utilization in the damaged hemisphere particularly evident in the cortex 3 days after the injury. The rate of development of these changes is not parallel with the observed damage to the blood-brain barrier, coexistent brain oedema and slight disturbances of cerebral blood flow. In a series of experiments it was possible to demonstrate significant accumulation of glucose, high-energy phosphate compounds and their metabolites in the areas of the brain near the damaged part. The authors think that this is an evidence of reduced glucose uptake by the brain resulting from reduced energy needs of the damaged brain tissue despite sufficient supply of energy-yielding substances. Since cerebral metabolism and functions are in close interrelationship reduced glucose metabolism in the damaged tissue leads to reduced activity of the cortex, which contributes to transient (or permanent) functional neurological deficits observed after cranio-cerebral trauma in humans. The knowledge and understanding of these processes regulating the development of local depression of cerebral metabolic processes may help in better results of treatment in such cases.
Buczek
M
M
Oddziału Neurotraumatologii, Katedry Neurochirurgii AM, Lodzi.
Ratcheson
R A
RA
Lust
W D
WD
McHugh
M
M
Pappius
H M
HM
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D001928:Brain Diseases, Metabolic / Q000209:etiology*; D001929:Brain Edema / Q000209:etiology*; D003080:Cold Temperature / Q000009:adverse effects*; D004195:Disease Models, Animal; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006019:Glycolysis / Q000502:physiology; D008297:Male; D010725:Phosphocreatine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D005947:Glucose
Efekty metaboliczne doświadczalnego, termicznego uszkodzenia mózgu u szczura--cold lesion.