Suppression of spontaneous murine lupus by inducing graft-versus-host reaction with CD8+ cells.
Splenic CD8+ (Lyt-2+) cells of C57BL/6 mice were injected into semiallogeneic (NZB x BXSB)F1 mice, which spontaneously develop lupus nephritis, in order to examine whether the disease was somehow modified by the occurrence of graft-versus-host reaction. The development of lupus nephritis in the F1 recipients was strongly inhibited and immunopathological parameters such as anti-DNA antibodies, circulating immune complexes (CIC) and splenic immunoglobulin-producing cells (IgPC) were markedly reduced. The injection of CD4+ (L3T4+) T cells into F1 recipients did not result in similar effects. These findings suggest that the development of autoimmune disease could be ameliorated by CD8+ cells responding to MHC class I antigens. The significance of the data is discussed in terms of the treatment of autoimmune diseases.
Ito
S
S
Department of Medicine (II), Niigata University School of Medicine, Japan.
Ueno
M
M
Nishi
S
S
Arakawa
M
M
Fujiwara
M
M
D000818:Animals; D000974:Antibodies, Antinuclear / Q000276:immunology; D000921:Antibody-Producing Cells / Q000276:immunology; D000936:Antigen-Antibody Complex / Q000378:metabolism; D001323:Autoantibodies / Q000096:biosynthesis; D016827:CD8 Antigens / Q000276:immunology; D015922:Complement C1q / Q000378:metabolism; D005455:Fluorescent Antibody Technique; D006087:Graft vs Host Reaction / Q000276:immunology*; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008181:Lupus Nephritis / Q000276:immunology; D051379:Mice; D013154:Spleen / Q000166:cytology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000974:Antibodies, Antinuclear; D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D016827:CD8 Antigens; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015922:Complement C1q