Increase of S-(1,2-dicarboxyethyl)glutathione in regenerating rat liver.
Changes in the level of S-(1,2-dicarboxyethyl)glutathione (DCE-GS) with time were determined during regeneration of rat liver after partial hepatectomy. The DCE-GS level increased in regenerating rat liver, reaching a maximum level (4.7-fold) on day 2 and reverted to the normal level in 1 week. During the liver regeneration process, the activity of DCE-GS-synthesizing enzyme in the liver retained its control level, while the level of glutathione--a substrate of the enzyme in the liver--fluctuated in parallel with that of DCE-GS.
Tsuboi
S
S
Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Miyazaki
M
M
Kondo
Y
Y
Kiyono
K
K
Fujiwara
E
E
Ogata
K
K
Sakaue
T
T
Namba
M
M
Ohmori
S
S
D000818:Animals; D005978:Glutathione / Q000031:analogs & derivatives* / Q000378:metabolism; D006498:Hepatectomy; D008099:Liver / Q000378:metabolism*; D008115:Liver Regeneration / Q000502:physiology*; D008297:Male; D008298:Maleates / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D008298:Maleates; C041581:S-(1,2-dicarboxyethyl)glutathione; C030272:maleic acid; D005978:Glutathione