[Ventricular late potentials in hypertrophic cardiomyopathy: personal contribution and analysis of the literature].
BACKGROUND
Patients with hypertrophic cardiomyopathy are at increased risk of sudden death. Recently it has been investigated whether late potentials can be useful markers of that risk in such patients, with discordant results. The aim of our study was to detect a correlation, if any, between late potentials, ventricular tachycardia and the hypertrophy extension.


METHODS
Twenty-five patients were enrolled, 19 males and 6 females, mean age 40.40 +/- 15.02 years. Each underwent 24h Holter monitoring, averaged ECG, M-Mode and 2-D Echo. The hypertrophy was considered extensive (septum and free wall) or non extensive (septum and/or apex).


RESULTS
Late potentials of a mean duration of 37 +/- 14.83 ms were recorded in 5/7 patients with documented ventricular tachycardia vs in none of the non tachycardia group. Sensibility was 100%, specificity 71% and predictive value 100%. Late potentials were present in 8.3% of patients with non extensive and in 30.8% of patients with extensive hypertrophy (p = NS).


CONCLUSIONS
From our data it seems that extensive hypertrophy is present in about half of patients with hypertrophic cardiomyopathy, and this roughly correlates with a more frequent ventricular tachycardia and with late potentials. Furthermore, late potentials are strictly related to the incidence of ventricular tachycardia in this disease, just as in ischemic heart disease or in idiopathic dilated cardiomyopathy. The small number of our cases may not be sufficient to reach a significant statistical correlation between late potentials and hypertrophy, but we believe that the trend is very promising.
Iannucci
G
G
IV Clinica Medica, Università Degli Studi di Roma La Sapienza.
Villani
M
M
Giacopello
F
F
Giordano
M
M
Cangelosi
A P
AP
Ciardo
R
R
Di Paolo
F M
FM
Sciacca
A
A
Baciarello
G
G
D000200:Action Potentials; D000293:Adolescent; D000328:Adult; D000368:Aged; D006332:Cardiomegaly / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002648:Child; D004562:Electrocardiography; D015716:Electrocardiography, Ambulatory; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D017180:Tachycardia, Ventricular / Q000209:etiology / Q000503:physiopathology*; D014463:Ultrasonography
I potenziali tardivi ventricolari nelle cardiomiopatie ipertrofiche: contributo personale ed esame della letteratura.