[A study on the relationship between maximal titers of anti-HBs antibodies and persistence of protective level after vaccination].
300 recipients with negative for HBsAg anti-HBs, anti-HBc were vaccinated by 3 kinds of hepatitis B vaccine at 0, 1, 6 months. 266 students with maximal titers of anti-HBs detected after the 3rd immunization were divided into 4 groups: 10-100, 101-500, 501-1,000, > 1000 mlU/ml. A study on the relationship between maximal titers of anti-HBs and the protective time was carried out. The results showed that in the 1st group the titers of anti-HBs of 52.6%, 84.2% and 94.7% recipients decreased to or below 10 mIU/ml when detected one, two and three years after vaccination respectively; the titers of 5.2%, 31% and 56.9% decreased to or below 10 mIU/ml when detected. 1, 2 and 3 years after vaccination respectively in the 2nd group, while the titers of only 0.7% recipients decreased to or below 10 mIU/ml when detected 3 years after vaccination in the 1st group. The decreasing rate of titers of Anti-HBs was similar in 4 groups. The titers of anti-HBs were 90% reduction after 1st immunization in the first 24 months. Then the decreasing rate became slower. Therefore, we suggested that peoples should be revaccinated according to their maximal titers of anti-HBs after completed course of vaccination.
Li
S Q
SQ
Department of Preventive Medicine, China Medical University, Shen Yang.
D000293:Adolescent; D000328:Adult; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D017325:Hepatitis B Vaccines; D006801:Humans; D007117:Immunization, Secondary; D008297:Male; D014611:Vaccination
D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines