title: Isoflurane anesthesia is stereoselective.
abstract: The anesthetic effects of the (+) and (-) isomers of isoflurane were determined in mice. Like the clinically important racemate, both isomers produced dose-dependent increases in anesthetic sleep time. A statistically significant (P less than 0.005, ANOVA) difference in the potencies of these isomers ((+) greater than (-)) was observed. To our knowledge, this is the first demonstration of a stereospecific action of a volatile anesthetic in vivo.
authors.affiliation: Laboratory of Neuroscience, NIDDK/NIH, Bethesda, MD 20892.
authors.forename: B
authors.initials: B
authors.lastname: Harris
authors.forename: E
authors.initials: E
authors.lastname: Moody
authors.forename: P
authors.initials: P
authors.lastname: Skolnick
mesh_terms: D000704:Analysis of Variance; D000758:Anesthesia; D000818:Animals; D007274:Injections, Intraperitoneal; D007530:Isoflurane / Q000008:administration & dosage; D008297:Male; D051379:Mice; D013237:Stereoisomerism
chemical_list: D007530:Isoflurane