title: [Synthesis and antitumor activity of beta-germanyl-alpha-amino acid derivatives].
abstract: Some beta-germanyl-alpha-amino acid derivatives were prepared from the reaction of HGeCl3 with substituted oxazolines. The compositions of the above compounds were studied using IR, element analysis and so on. Experimental results were as follows: for 1-substituted-2-amino-2-carboxyethylgermanium susquioxide (such as IIIb), the po LD50 for mice was found to be above 10 g/kg. When given ip, a maximum inhibition of 50% of the growth of S180 was obtained for IIIb, whereas an inhibition of 42% was achieved for 5-Fu under the same experimental condition.
authors.affiliation: School of Pharmacy, Tongji Medical University, Wuhan.
authors.forename: F C
authors.initials: FC
authors.lastname: Jiang
authors.forename: W D
authors.initials: WD
authors.lastname: Ma
authors.forename: S C
authors.initials: SC
authors.lastname: Cheng
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D007928:Lethal Dose 50; D051379:Mice; D012510:Sarcoma 180 / Q000188:drug therapy
chemical_list: D000596:Amino Acids; D000970:Antineoplastic Agents