Pretransfusion incubation of apheresis platelets at 37 degrees C improves posttransfusion recovery.
The effect of brief 37 degrees C pretransfusion incubation of apheresis platelets (n = 25) was studied in 14 allogenic bone marrow transplant recipients (5 children, 9 adults). Apheresis platelets were collected on a cell separator, divided in two aliquots, and stored 1 to 5 days at 22 degrees C during agitation. One aliquot was incubated at 37 degrees C for 1 hour before transfusion, and the other was transfused as a paired control. When the patient's peripheral platelet count fell below 30 x 10(9) per L, one aliquot was transfused. The other aliquot was transfused the following day. Each patient received the two aliquots in random order. Corrected count increment (CCI) at 1 hour after transfusion of 37 degrees C incubated platelets was 12.2 +/- 9.5 (mean +/- SD) compared to 7.5 +/- 5.4 for paired control platelets (p < 0.05). CCIs the next day were 4.4 +/- 6.1 and 2.4 +/- 2.7, respectively (not significant). It can be concluded that 37 degrees C incubation of apheresis platelets improves posttransfusion CCI.
Shanwell
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Stockholm Blood Transfusion Service, Huddinge Hospital, Sweden.
Wikman
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Ringdén
O
O
D000328:Adult; D001792:Blood Platelets; D001793:Blood Preservation; D001803:Blood Transfusion; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D010976:Platelet Count; D010983:Plateletpheresis; D012044:Regression Analysis; D013696:Temperature; D013997:Time Factors