Age-associated changes in mesenteric arteries.
Vascular disease increases in incidence with age and is the commonest cause of morbidity and mortality among elderly people. Hypertension is associated with hypertrophy of the arterial media. This study was designed to investigate changes in arterial structure that may occur with age independent of blood pressure. Collapsed sections of human mesenteric arteries (external diameter 2-3 mm) were measured using a semi-automatic image analysis system. There was a nonlinear increase in both the wall/lumen area ratio and the relative intimal area with age. There were no significant relationships between blood pressure and either the wall/lumen ratio or the relative intimal area.
Balsitis
M
M
Department of Physiology and Pharmacology, University of Strathclyde, Glasgow.
MacDonald
E
E
McDonald
A
A
Davidson
I
I
Fulton
J D
JD
Scott
P J
PJ
Wadsworth
R
R
Wilkinson
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D005352:Fibromuscular Dysplasia / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000473:pathology; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation; D015212:Inflammatory Bowel Diseases / Q000473:pathology; D007414:Intestinal Neoplasms / Q000473:pathology; D008297:Male; D008638:Mesenteric Arteries / Q000473:pathology; D008641:Mesenteric Vascular Occlusion / Q000473:pathology*; D008838:Microcomputers; D008853:Microscopy / Q000295:instrumentation; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000473:pathology*