title: Chronic neutrophilic leukemia (CNL) with karyotypic abnormalities associated with plasma cell dyscrasia: a case report.
abstract: A case of chronic neutrophilic leukemia (CNL), a rare myeloproliferative syndrome associated with monoclonal gammopathy of uncertain significance (MGUS-Type IgGk), is reported. Karyotypic study, carried out on bone marrow, excluded Philadelphia-pos. chronic myeloid leukemia (CML) and showed Y loss (45 XO). Only a few cases of CNL with paraproteinemia have been reported, but no case of associated karyotypic abnormalities and paraproteinemia has so far been described.
authors.affiliation: I Divisione Medica, Arcispedale S. Maria Nuova, Reggio Emilia, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Masini
authors.forename: C
authors.initials: C
authors.lastname: Salvarani
authors.forename: P
authors.initials: P
authors.lastname: Macchioni
authors.forename: G
authors.initials: G
authors.lastname: Baldi
authors.forename: F
authors.initials: F
authors.lastname: Rossi
authors.forename: G
authors.initials: G
authors.lastname: Croci
authors.forename: S
authors.initials: S
authors.lastname: Prandi
authors.forename: C
authors.initials: C
authors.lastname: Davoli
authors.forename: I
authors.initials: I
authors.lastname: Portioli
authors.forename: F
authors.initials: F
authors.lastname: Gobbi
mesh_terms: D000368:Aged; D002872:Chromosome Deletion; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007145:Immunoglobulin kappa-Chains / Q000097:blood*; D007621:Karyotyping; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Q000150:complications* / Q000235:genetics; D015467:Leukemia, Neutrophilic, Chronic / Q000150:complications* / Q000235:genetics; D008297:Male; D010265:Paraproteinemias / Q000209:etiology*; D014998:Y Chromosome
chemical_list: D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains