Effects of medicinal plants on hemopoietic cells.
It has been found that Juzentaihoto (TJ-48), one of the traditional Japanese kampo (herbal) medicines, improves the general condition of cancer patients receiving chemotherapy and radiation therapy. We analyze how TJ-48 elicits such effect, and show that oral administration of TJ-48 accelerates recovery from hemopoietic injury induced by radiation and the anti-cancer drug mitomycin C. The effects are found to be due to its stimulation of spleen colony-forming units. Based on the present findings, we propose that the administration of TJ-48 should be of benefit to patients receiving chemotherapy, radiation therapy or bone marrow transplantation.
Ikehara
S
S
1st Department of Pathology, Kansai Medical University, Osaka, Japan.
Kawamura
H
H
Komatsu
Y
Y
Yamada
H
H
Hisha
H
H
Yasumizu
R
R
Ohnishi-Inoue
Y
Y
Kiyohara
H
H
Hirano
M
M
Aburada
M
M
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D003114:Colony-Forming Units Assay; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects / Q000528:radiation effects; D006413:Hematopoietic System / Q000166:cytology* / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051379:Mice; D016685:Mitomycin / Q000633:toxicity; D010946:Plants, Medicinal / Q000276:immunology*
D000276:Adjuvants, Immunologic; D004365:Drugs, Chinese Herbal; C063587:juzentaihoto; D016685:Mitomycin