Severity of hepatic encephalopathy before liver transplantation is associated with quality of life after transplantation.
BACKGROUND
Cirrhosis is associated with a chronic low-grade hepatic encephalopathy and disturbances in quality of life. This study investigated the extent to which severity of hepatic encephalopathy before orthotopic liver transplantation correlated with quality of life.


METHODS
A battery of neuropsychological tests was administered to nonalcoholic patients to quantify severity of hepatic encephalopathy. The Sickness Impact Profile was administered before and after surgery to document quality of life across multiple health and psychosocial dimensions.


RESULTS
There was substantial improvement from the pretransplant to the posttransplant periods across almost all dimensions of quality of life. Neuropsychological test scores explained up to 20% of the variance in magnitude of change from pre (before) to post (after) surgery.


CONCLUSIONS
Severity of hepatic encephalopathy (particularly with respect to static ataxia and fine motor control) is associated with posttransplantation improvement in quality of life.
Tarter
R E
RE
Department of Psychiatry, University of Pittsburgh, PA.
Switala
J
J
Plail
J
J
Havrilla
J
J
Van Thiel
D H
DH
D000328:Adult; D005260:Female; D006501:Hepatic Encephalopathy / Q000523:psychology* / Q000601:surgery*; D006801:Humans; D016031:Liver Transplantation / Q000523:psychology*; D008297:Male; D009483:Neuropsychological Tests; D011379:Prognosis; D011788:Quality of Life; D012044:Regression Analysis; D013997:Time Factors