title: [Changes in cellular radiosensitivity by modifying the cytoplasmic membranes].
abstract: The radiosensitivity of mouse myeloma and E. coli cells in the presence of Mg2+ and UO2(2+) ions has been investigated. It has been shown that Mg2+ ions (10(-4) M) do not influence the viability of E. coli and mouse myeloma cells. The presence of Mg2+ ions during irradiation reduces the survival rate of E. coli cells, but the addition of Mg2+ ions after irradiation does not influence the radiosensitivity of E. coli cells. Comparison of the results on the influence of Mg2+ ions upon cells and bilayer lipid membranes (BLM) permits us to suppose that Mg2+ ions increase the positive charge of the membranes thus promoting the increase in the number of short-lived radiolysis products which impair membranes and increase cell radiosensitivity. UO2(2+) ions (10(-4) M) increase the radioresistance of E. coli cells which can be associated with the increase in the lateral membrane viscosity, as it was shown in the studies on BLM.
authors.forename: M S
authors.initials: MS
authors.lastname: Iarova
authors.forename: A G
authors.initials: AG
authors.lastname: Pribush
authors.forename: L I
authors.initials: LI
authors.lastname: Fedorova
authors.forename: I G
authors.initials: IG
authors.lastname: Abidor
authors.forename: A N
authors.initials: AN
authors.lastname: Petrov
authors.forename: A V
authors.initials: AV
authors.lastname: Kulikov
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000528:radiation effects*; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004926:Escherichia coli / Q000187:drug effects / Q000528:radiation effects; D008051:Lipid Bilayers / Q000528:radiation effects; D008274:Magnesium / Q000494:pharmacology; D008563:Membrane Lipids / Q000528:radiation effects; D051379:Mice; D009101:Multiple Myeloma; D011836:Radiation Tolerance; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000528:radiation effects; D014501:Uranium / Q000494:pharmacology; D017974:Uranium Compounds
chemical_list: D008051:Lipid Bilayers; D008563:Membrane Lipids; D017974:Uranium Compounds; D014501:Uranium; D008274:Magnesium; C012597:uranium dioxide
vernacular_title: Izmenenie radiochuvstvitel'nosti kletok putem modifikatsii tsitoplazmaticheskikh membran.