Chiral separation by capillary electrophoresis with oligosaccharides.
Maltodextrins, i.e., mixtures of linear alpha-(1-4)-linked D-glucose polymers, were found to be effective as chiral electrolyte modifiers to perform direct, rapid separations by capillary electrophoresis of racemic mixtures of 2-arylpropionic acid non-steroidal anti-inflammatory compounds and coumarinic anticoagulant drugs, and also diastereomeric cephalosporin antibiotics. Enantioselectivity seemed to be dependent on an as yet unidentified combination of variables.
D'Hulst
A
A
Catholic University of Leuven, Gasthuisberg, Belgium.
Verbeke
N
N
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis; D002511:Cephalosporins / Q000032:analysis; D003374:Coumarins / Q000032:analysis; D004573:Electrolytes; D004586:Electrophoresis; D005947:Glucose / Q000032:analysis; D009844:Oligosaccharides / Q000302:isolation & purification*; D011134:Polysaccharides / Q000032:analysis; D013237:Stereoisomerism; D014462:Ultrafiltration
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002511:Cephalosporins; D003374:Coumarins; D004573:Electrolytes; D009844:Oligosaccharides; D011134:Polysaccharides; C008315:maltodextrin; D005947:Glucose