title: Porcine model for studying the passage of non-depolarizing neuromuscular blockers through the blood-brain barrier.
abstract: A method has been developed for blood-brain barrier disruption to provide reproducible access to the cerebrospinal fluid of the cerebello-medullary cistern. The technique was used successfully to investigate transfer of pancuronium to the cerebral CSF compartment in pigs. After osmotic disruption of the blood-brain barrier, pancuronium concentrations increased significantly in the cerebrospinal fluid.
authors.affiliation: Clinic of Anaesthesia, University of Vienna, Austria.
authors.forename: A
authors.initials: A
authors.lastname: Werba
authors.forename: H
authors.initials: H
authors.lastname: Gilly
authors.forename: M
authors.initials: M
authors.lastname: Weindlmayr-Goettel
authors.forename: C K
authors.initials: CK
authors.lastname: Spiss
authors.forename: K
authors.initials: K
authors.lastname: Steinbereithner
authors.forename: T
authors.initials: T
authors.lastname: Czech
authors.forename: S
authors.initials: S
authors.lastname: Agoston
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D017536:Carotid Artery, Common; D008026:Ligation; D008954:Models, Biological; D003473:Neuromuscular Nondepolarizing Agents / Q000493:pharmacokinetics*; D010197:Pancuronium / Q000097:blood / Q000134:cerebrospinal fluid; D013552:Swine
chemical_list: D003473:Neuromuscular Nondepolarizing Agents; D010197:Pancuronium