title: Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14.
abstract: Linkage analysis was used to search the genome for chromosomal regions harboring familial Alzheimer's disease genes. Markers on chromosome 14 gave highly significant positive lod scores in early-onset non-Volga German kindreds; a Zmax of 9.15 (theta = 0.01) was obtained with the marker D14S43 at 14q24.3. One early-onset family yielded a lod score of 4.89 (theta = 0.0). When no assumptions were made about age-dependent penetrance, significant results were still obtained (Zmax = 5.94, theta = 0.0), despite the loss of power to detect linkage under these conditions. Results for the Volga German families were either negative or nonsignificant for markers in this region. Thus, evidence indicates a familial Alzheimer's disease locus on chromosome 14.
authors.forename: G D
authors.initials: GD
authors.lastname: Schellenberg
authors.forename: T D
authors.initials: TD
authors.lastname: Bird
authors.forename: E M
authors.initials: EM
authors.lastname: Wijsman
authors.forename: H T
authors.initials: HT
authors.lastname: Orr
authors.forename: L
authors.initials: L
authors.lastname: Anderson
authors.forename: E
authors.initials: E
authors.lastname: Nemens
authors.forename: J A
authors.initials: JA
authors.lastname: White
authors.forename: L
authors.initials: L
authors.lastname: Bonnycastle
authors.forename: J L
authors.initials: JL
authors.lastname: Weber
authors.forename: M E
authors.initials: ME
authors.lastname: Alonso
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D001483:Base Sequence; D002883:Chromosomes, Human, Pair 14; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes / Q000235:genetics; D010375:Pedigree
chemical_list: D015345:Oligonucleotide Probes