Single umbilical artery ligation-induced fetal growth retardation: effect on postnatal adaptation.
To assess whether prolonged intrauterine stress and resultant fetal growth retardation result in depletion of adrenal catecholamines and alter the adrenergic signal transduction system, we studied newborn sheep after single umbilical artery ligation (SUAL)-induced growth retardation. The animals were delivered at term, and postnatal cardiovascular, pulmonary, endocrine, and metabolic responses were measured. We also evaluated the status of myocardial and pulmonary beta-adrenergic receptor number and function. SUAL caused significant growth retardation but relative preservation of brain and adrenal gland weight and adrenal catecholamine content. Blood pressure, plasma free fatty acid, and glucose responses at birth were blunted in SUAL animals. The plasma epinephrine (Epi) and norepinephrine levels were comparable in both groups for the first 2 h of age. By 4 h, both plasma concentration and plasma appearance rate of Epi were reduced to 40% of control in SUAL animals (P less than 0.05). Neither beta-receptor density, affinity, nor adenylate cyclase activity were altered by SUAL in either cardiac or pulmonary membranes. These results suggest that, rather than overt depletion, there is relative sparing of initial adrenal medullary function that later waned. This response and preservation of the beta-adrenergic signal transduction system may represent partial compensation for the physiological stress induced by SUAL.
Oyama
K
K
Perinatal Research Laboratories, University of California Los Angeles School of Medicine, Torrance 90509.
Padbury
J
J
Chappell
B
B
Martinez
A
A
Stein
H
H
Humme
J
J
D000222:Adaptation, Physiological; D000262:Adenylyl Cyclases / Q000378:metabolism; D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn / Q000097:blood / Q000502:physiology*; D002908:Chronic Disease; D004837:Epinephrine / Q000378:metabolism; D005317:Fetal Growth Retardation / Q000209:etiology / Q000503:physiopathology*; D006439:Hemodynamics; D008026:Ligation; D009206:Myocardium / Q000201:enzymology; D009638:Norepinephrine / Q000378:metabolism; D012756:Sheep / Q000196:embryology; D013312:Stress, Physiological / Q000150:complications; D014469:Umbilical Arteries
D000262:Adenylyl Cyclases; D009638:Norepinephrine; D004837:Epinephrine