[Local anesthetics. 99. Synthesis and local anesthetic actions of alkoxyphenylcarbamates].
Within the framework of studying the influence of alterations of the connecting chain in the group of local anaesthetics a series of 24 compounds of 1-propoxymethyl-2-(1-pyrrolidinyl), 2-(1-piperidino)-, and 2-(1-perhydroazepinyl)-ethyl esters of o- and m-alkoxyphenylcarbamic acid were prepared. Studied compounds show a high index of relative local anaesthetic activity as compared to the standards cocaine and procaine, at a relatively low acute toxicity.
Búciová
L
L
Lehrstuhl für Pharmazeutische Chemie der Pharmazeutischen Fakultät der Komensky-Universität, Bratislava, CSFR.
Csöllei
J
J
Racanská
E
E
Svec
P
P
D000779:Anesthetics, Local / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D002219:Carbamates / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051379:Mice
D000779:Anesthetics, Local; D002219:Carbamates
Untersuchungen an Lokalanästhetika, 99.Mitt.: Synthese und lokalanästhetische Wirkung von Alkoxyphenylcarbamaten.