[Effect of drugs inhibiting the formation of hydroxide radicals on healing of experimental corneal ulcer].
The 60 per cent water solution of dimethyl sulfoxide (DMSO) was used in the investigations. It was instilled into the conjunctival sac of an eye with experimental corneal ulceration. The dimethyl sulfoxide is inhibiting the formation of hydroxide radicals which cause a damage of the tissue in the course of inflammation. Clinical observations as well as histochemical and histopathological examinations showed that ulcerations treated by dimethyl sulfoxide healed faster than those from the control group and reactions to acid mucopolysaccharides++ returned more rapidly to normal values.
Toczołowski
J
J
Oddziału Okulistycznego Wojewódzkiego Szpitala Nr 2 w Lublinie.
Wolski
T
T
Klamut-Sory
K
K
D000818:Animals; D000975:Antioxidants; D003228:Conjunctiva / Q000187:drug effects; D003320:Corneal Ulcer / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage* / Q000494:pharmacology; D004195:Disease Models, Animal; D005126:Eye Burns / Q000150:complications*; D005609:Free Radicals; D006878:Hydroxides / Q000037:antagonists & inhibitors*; D009883:Ophthalmic Solutions; D011817:Rabbits; D014945:Wound Healing / Q000187:drug effects
D000975:Antioxidants; D005609:Free Radicals; D006878:Hydroxides; D009883:Ophthalmic Solutions; C031356:hydroxide ion; D004121:Dimethyl Sulfoxide
Wpływ środków hamujqcych powstawanie rodników wodorotlenowych na gojenie sie doświadczalnego owrzodzenia rogówki.