Both cyclooxygenase and lipoxygenase inhibitor partially restore the anorexia by interleukin-1 beta.
Since the peripheral prostaglandin synthetizing system may at least partly involved in the anorexia that follows central interleukin-1 beta (IL-1) administration, this study was undertaken to investigate the effect of ibuprofen (ip), selective cyclooxygenase blocker and AA 861, selective lipoxygenase inhibitor, on changes of food and water intake by a single injection of IL-1 (2 micrograms/rat, ip). We demonstrated that food and water intake were suppressed by peripheral administration of IL-1. Throughout the entire observation periods, suppressed food intake was partially restored to control levels by ibuprofen, while water intake completely restored. In addition, no significant differences about water/food intake were observed in the IL-1 + ibuprofen-treated groups, respectively. In the next experiment, IL-1 induced anorexia was also partially restored to the control level following pretreatment with AA 861. These results may suggest that other mechanism including lipoxygenase blocker besides prostaglandin production may be involved in IL-1 induced anorexia.
Shimomura
Y
Y
First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.
Inukai
T
T
Kuwabara
S
S
Shimizu
H
H
Takahashi
M
M
Sato
N
N
Uehara
Y
Y
Tanaka
Y
Y
Kobayashi
I
I
D000704:Analysis of Variance; D000818:Animals; D001069:Appetite Regulation / Q000187:drug effects*; D016227:Benzoquinones / Q000494:pharmacology*; D002940:Circadian Rhythm; D004326:Drinking / Q000187:drug effects; D007052:Ibuprofen / Q000494:pharmacology*; D007375:Interleukin-1 / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D016227:Benzoquinones; D007375:Interleukin-1; D016859:Lipoxygenase Inhibitors; C036837:2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone; D007052:Ibuprofen