Abnormal haemoglobin electrophoresis caused by BW 12C.
BW 12C, a substituted benzaldehyde, stabilises haemoglobin in the oxy-conformation and has attracted interest as an anti-sickling agent. The drug causes a left shift in the oxygen saturation curve and may induce tumour anoxia and enhance the effect of cytotoxic drugs. During clinical trials in patients with cancer abnormal bands on haemoglobin electrophoretic strips were observed. This made correct diagnosis of abnormal haemoglobins impossible. Solubility tests for sickling disorders (Itano) also proved unreliable.
van Rhee
F
F
Department of Haematology, John Radcliffe Hospital, Headington, Oxford.
Ware
I
I
Littlewood
T
T
D000230:Adenocarcinoma / Q000188:drug therapy; D000755:Anemia, Sickle Cell / Q000175:diagnosis*; D000970:Antineoplastic Agents / Q000494:pharmacology; D001547:Benzaldehydes / Q000494:pharmacology*; D001797:Blood Protein Electrophoresis; D005188:False Negative Reactions; D006454:Hemoglobins / Q000032:analysis / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged
D000970:Antineoplastic Agents; D001547:Benzaldehydes; D006454:Hemoglobins; C039599:5-(2-formyl-3-hydroxyphenoxy)pentanoic acid