Mutagenic activity of copper(II) chromate and dichromate complexes with polypyridines.
Copper(II) chromate and dichromate complexes with 2,2'-bipyridyl and 1,10-phenathroline were tested for their mutagenic activity in the standard Ames test. All of six tested complexes exhibited markedly lower mutagenic activity than the reference compounds--potassium dichromate and sodium chromate. The blockage of Cr(VI) reduction capability in the presence of the complex Cu2+ ion and the competition between copper and chromium ions in the interaction with cellular components are discussed in the light of the results of our previous chemical study.
Szyba
K
K
Department of Basic Medical Sciences, Medical Academy, Wrocław, Poland.
Golonka
M C
MC
Gasiorowski
K
K
Urban
J
J
D015082:2,2'-Dipyridyl / Q000633:toxicity*; D002840:Chromates / Q000633:toxicity*; D003300:Copper / Q000633:toxicity*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D010084:Oxidation-Reduction; D010618:Phenanthrolines / Q000633:toxicity*; D011192:Potassium Dichromate / Q000633:toxicity; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D017670:Sodium Compounds
D002840:Chromates; D009153:Mutagens; D010618:Phenanthrolines; D017670:Sodium Compounds; D015082:2,2'-Dipyridyl; C028982:sodium chromate(VI); D003300:Copper; D011192:Potassium Dichromate; C025205:1,10-phenanthroline