title: [Endoscopic analysis of gastric mucosal lesions in patients with adult T-cell leukemia during chemotherapy].
abstract: Gastric mucosal lesions in 13 patients with adult T-cell leukemia (ATL) were endoscopically studied at least at 2 occasions during chemotherapy for these patients. X-ray examinations by using barium meal showed deformities in 10 patients and abnormal mucosal pattern in 11 out of 13 patients with ATL. The endoscopic examinations revealed gastric ulcers in 5 patients, erosion in 8, diffuse bleeding in 2, tumorous mucosal folds in one, and submucosal tumor in one patient. In 9 out of 12 ATL patients, pathological study revealed that ATL cells had invaded the mucosal area of the stomach. The ulcers and erosions were improved by chemotherapy in 3 out of 5 and 5 out of 8 patients, respectively, whereas the erosion was not reduced in 2 and even aggravated in one patient. Interestingly, the gastric lesions formed by ATL cell invasion were improved by the administration of anticancer agents in 5 out of 9 patients. However, these lesions reappeared together with systemic lesions of ATL.
authors.affiliation: Second Dept. of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Utsunomiya
authors.forename: M
authors.initials: M
authors.lastname: Otsuka
authors.forename: T
authors.initials: T
authors.lastname: Makino
authors.forename: T
authors.initials: T
authors.lastname: Saito
authors.forename: K
authors.initials: K
authors.lastname: Uozumi
authors.forename: Y
authors.initials: Y
authors.lastname: Takasaki
authors.forename: S
authors.initials: S
authors.lastname: Hanada
authors.forename: M
authors.initials: M
authors.lastname: Tokunaga
authors.forename: H
authors.initials: H
authors.lastname: Nishimata
authors.forename: T
authors.initials: T
authors.lastname: Arima
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D005260:Female; D005753:Gastric Mucosa / Q000000981:diagnostic imaging / Q000473:pathology*; D005773:Gastroscopy; D006801:Humans; D015458:Leukemia, T-Cell / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011859:Radiography; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology*; D013276:Stomach Ulcer / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents