Linkage heterogeneity between the C3 and LDLR and the APOA4 and APOA1 loci in baboons.
We detected linkage in baboons between loci for the third component of complement (C3) and the low-density lipoprotein receptor (LDLR), lod score = 5.53, and loci for apolipoprotein A1 (APOA1) and apolipoprotein AIV (APOA4), lod score = 14.59. We also found evidence for linkage heterogeneity among the baboon pedigrees between LDLR and C3 (P = 0.04) and between APOA1 and APOA4 (P = 0.01).
Kammerer
C M
CM
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78228-0147.
Hixson
J E
JE
Aivaliotis
M J
MJ
Porter
P A
PA
VandeBerg
J L
JL
D000818:Animals; D016632:Apolipoprotein A-I / Q000235:genetics*; D001054:Apolipoproteins A / Q000235:genetics*; D003176:Complement C3 / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D008126:Lod Score; D008297:Male; D010215:Papio / Q000235:genetics*; D011973:Receptors, LDL / Q000235:genetics*; D011995:Recombination, Genetic
D016632:Apolipoprotein A-I; D001054:Apolipoproteins A; D003176:Complement C3; D005819:Genetic Markers; D011973:Receptors, LDL; C022205:apolipoprotein A-IV