title: High-dose fluoxetine in the treatment of depressed patients not responsive to a standard dose of fluoxetine.
abstract: In a four-week, open label study of major depression, 15 patients who had failed to respond to a trial of fluoxetine 20 mg/day of 8-12 weeks duration were then treated with fluoxetine 40 mg/day for one week and then, if tolerated, with either 60 or 80 mg/day. The mean HAM-D-17 and CGIS scores of these 15 patients decreased significantly at the end of 4 weeks on a higher dosage of fluoxetine (60 or 80 mg/day) with respect to the beginning of the four-week study. No significant side-effects were noted.
authors.affiliation: Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114.
authors.forename: M
authors.initials: M
authors.lastname: Fava
authors.forename: J F
authors.initials: JF
authors.lastname: Rosenbaum
authors.forename: L
authors.initials: L
authors.lastname: Cohen
authors.forename: S
authors.initials: S
authors.lastname: Reiter
authors.forename: M
authors.initials: M
authors.lastname: McCarthy
authors.forename: R
authors.initials: R
authors.lastname: Steingard
authors.forename: K
authors.initials: K
authors.lastname: Clancy
mesh_terms: D000293:Adolescent; D000328:Adult; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005473:Fluoxetine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D005473:Fluoxetine