title: MRI and SPECT findings in amyotrophic lateral sclerosis. Demonstration of upper motor neurone involvement by clinical neuroimaging.
abstract: MRI was performed in 21 patients and single photon emission computed tomography (SPECT) with N-isopropyl-p-123I iodoamphetamine in 16 patients, to visualize upper motor neurone lesions in amyotrophic lateral sclerosis. T2-weighted MRI revealed high signal along the course of the pyramidal tract in the internal capsule and cerebral peduncle in 4 of 21 patients. SPECT images were normal in 4 patients, but uptake was reduced in the cerebral cortex that includes the motor area in 11.
authors.affiliation: Department of Neurology, Sumitomo Hospital, Osaka, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Udaka
authors.forename: H
authors.initials: H
authors.lastname: Sawada
authors.forename: N
authors.initials: N
authors.lastname: Seriu
authors.forename: K
authors.initials: K
authors.lastname: Shindou
authors.forename: N
authors.initials: N
authors.lastname: Nishitani
authors.forename: M
authors.initials: M
authors.lastname: Kameyama
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000662:Amphetamines; D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis* / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000473:pathology; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008279:Magnetic Resonance Imaging; D008297:Male; D008636:Mesencephalon / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D009044:Motor Cortex / Q000000981:diagnostic imaging / Q000473:pathology; D009046:Motor Neurons / Q000000981:diagnostic imaging* / Q000473:pathology*; D009413:Nerve Fibers, Myelinated / Q000000981:diagnostic imaging / Q000473:pathology; D011712:Pyramidal Tracts / Q000000981:diagnostic imaging / Q000473:pathology; D012026:Reflex, Stretch / Q000502:physiology; D015899:Tomography, Emission-Computed, Single-Photon; D014855:Wallerian Degeneration
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine