title: Activation of human complement system in paracoccidioidomycosis.
abstract: Plasma samples of 14 patients with paracoccidioidomycosis were analysed for components that represent activation of the complement system. Most patients (12/13) showed significant titres of complement-fixing antibodies and 14/14 had increased C4d/C4 ratios. There was no conclusive correlation between these two immunological indices, however. Factor B values of patients were similar to normal donors and fragment Ba was not detected in any of the patients. These results indicate a classical complement pathway activation in the plasma of patients with paracoccidioidomycosis.
authors.affiliation: Departamento de Imunologia, Universidade de São Paulo, Brazil.
authors.forename: M E
authors.initials: ME
authors.lastname: Munk
authors.forename: A
authors.initials: A
authors.lastname: Kajdacsy-Balla
authors.forename: G
authors.initials: G
authors.lastname: Del Negro
authors.forename: L C
authors.initials: LC
authors.lastname: Cuce
authors.forename: W D
authors.initials: WD
authors.lastname: Da Silva
mesh_terms: D000293:Adolescent; D000328:Adult; D000908:Antibodies, Fungal / Q000097:blood; D002648:Child; D003167:Complement Activation / Q000276:immunology*; D003181:Complement C4 / Q000032:analysis; D011415:Complement Factor B / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010228:Paracoccidioides / Q000276:immunology; D010229:Paracoccidioidomycosis / Q000276:immunology*
chemical_list: D000908:Antibodies, Fungal; D003181:Complement C4; D011415:Complement Factor B