[Comparative analysis of antiarrhythmic action and electrophysiological effects of a new benzodiazepine derivative gidazepam and ethacizin in arrhythmias of various genesis].
The antiarrhythmic and electrophysiological effects of the new benzodiazepine tranquilizer gidazepam versus ethacizin were examined in patients with cardiac arrhythmias. The antiarrhythmic effect of the agent was found during 24-day monitoring and simulated psychoemotional stress in 81% of patients with neurocirculatory dystonia and in 61% of patients with coronary heart disease. The antiarrhythmic effects developed with gidazepam-induced changes in electrophysiological properties of the cardiac conduction system. The preventive antiarrhythmic effect of gidazepam was demonstrated to be higher than that of ethacizin during stress in patients with arrhythmias of extra-ischemic genesis.
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D000293:Adolescent; D000328:Adult; D000368:Aged; D014151:Anti-Anxiety Agents; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000627:therapeutic use*; D002304:Cardiac Pacing, Artificial; D015716:Electrocardiography, Ambulatory; D004594:Electrophysiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016293:Moricizine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D013997:Time Factors
D014151:Anti-Anxiety Agents; D000889:Anti-Arrhythmia Agents; D001570:Benzodiazepinones; D011619:Psychotropic Drugs; C027240:diethylamino-ethmozine; D001569:Benzodiazepines; D016293:Moricizine; C077010:gidazepam
Sravnitel'nyĭ analiz antiaritmicheskogo deĭstviia i élektrofiziologicheskikh éffektov novogo proizvodnogo benzodiazepina gidazepama i étatsizina pri aritmiiakh serdtsa razlichnogo geneza.