[The metabolism of albendazole in the isolated perfused intestine of rats].
Pharmacokinetic studies on Albendazole after peroral administration demonstrate a rapid and complete biotransformation. The major metabolites Albendazole sulphoxide and -sulphone were detected in the plasma; the parent compound was only found sporadically at very low levels. These results indicate removal by the liver and/or the gut at first pass. After evidence is found that the liver has the capacity to sulphoxidize and to sulphonize Albendazole, biotransformation of the gut was examined using an isolated perfused rat gut model. A high-performance liquid chromatography method was used to simultaneously determinate Albendazole, -sulphoxide and -sulphone. Albendazole was biotransformed partly to Albendazole sulphoxide by the gut, whereby the metabolite but not the parent compound was absorbed. It is concluded, that the gut has the capacity to biotransform Albendazole. However, biotransformation is limited to the first step, the sulphoxidation.
Lawrenz
A
A
Bundesgesundheitsamt, Robert-von-Ostertag-Institut, Berlin.
Eglit
S
S
Kroker
R
R
D015766:Albendazole / Q000493:pharmacokinetics*; D000818:Animals; D001711:Biotransformation; D046508:Culture Techniques; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013047:Specific Pathogen-Free Organisms; D013450:Sulfones / Q000378:metabolism; D013454:Sulfoxides / Q000378:metabolism
D013450:Sulfones; D013454:Sulfoxides; D015766:Albendazole
Untersuchungen zur Metabolisierung von Albendazol am isoliert perfundierten Darm von Ratten.