title: Fluids of the brain and the pathogenesis of MS.
abstract: The plaques of multiple sclerosis are generally thought to spread outwards from central veins. We propose that periventricular plaques in the cerebral hemispheres, and superficial plaques in the brain stem and spinal cord, point to the importance of demyelinating factors in the cerebrospinal fluid.
authors.affiliation: Department of Neurochemistry, Institute of Neurology, London.
authors.forename: E J
authors.initials: EJ
authors.lastname: Thompson
authors.forename: A
authors.initials: A
authors.lastname: Zeman
mesh_terms: D001826:Body Fluids / Q000502:physiology*; D001923:Brain Chemistry / Q000502:physiology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000209:etiology / Q000473:pathology