Evaluation of the teicoplanin broth microdilution and disk diffusion susceptibility tests and recommended interpretive criteria.
Comparative teicoplanin in vitro susceptibility data were generated for 1201 Gram-positive US clinical trial isolates using standardized broth microdilution and disk diffusion techniques. Based on the results of this study, the following interpretive criteria for teicoplanin are recommended: for MIC tests, less than or equal to 8 micrograms/ml = susceptible, 16 micrograms/ml = moderately susceptible, and greater than or equal to 32 micrograms/ml = resistant; and for disk (30 micrograms) tests, greater than or equal to 14 mm = susceptible, 11-13 mm = intermediate, and less than or equal to 10 mm = resistant.
Kenny
M T
MT
Marion Merrell Dow Research Institute, Indianapolis, IN 46368-0470.
Mayer
G D
GD
Dulworth
J K
JK
Brackman
M A
MA
Farrar
K
K
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D005069:Evaluation Studies as Topic; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D017334:Teicoplanin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D017334:Teicoplanin