[Acute and chronic hypotensive effect of m-nifedipine].
Three groups of adult stroke--prone spontaneously hypertensive rats (SHRsp) were treated with m-nifedipine (m-Nif) 2.5, 5 and 10 mg.kg-1 by intraperitoneal injection. The systolic blood pressure (SBp) decreased significantly. The hypotensive effect persisted for 2-4, 6-8, and 12 h respectively and the peak effect appeared in 1 h. The range of hypotension was markedly greater than that of nifedipine (Nif). In SHPsp, treatment with m-Nif 10 or 30 mg.kg-1.d-1 for 4 weeks reduced significantly the SBp, but the hypotensive action is about the same as Nif.
Wang
W
W
Cardiovascular Institute, Chinese Academy of Medical Sciences, Beijing.
Zhang
X E
XE
Liu
L S
LS
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000503:physiopathology; D007536:Isomerism; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR
D000959:Antihypertensive Agents; D009543:Nifedipine