Penicillin-induced immune-mediated hemolytic anemia in a horse.
A 5-year-old female American Quarter Horse was determined to have immune-mediated hemolytic anemia after detection of a positive response to a direct Coombs' test. Penicillin-induced immune-mediated hemolytic anemia was confirmed via a direct antiglobulin test, using penicillin-coated RBC. The horse was clinically improved and the anemia resolved in response to supportive care and discontinuation of penicillin treatment. Penicillin should be considered a possible cause of immune-mediated hemolytic anemia in horses.
McConnico
R S
RS
Department of Food Animal and Equine Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606.
Roberts
M C
MC
Tompkins
M
M
D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced / Q000662:veterinary*; D000818:Animals; D003298:Coombs Test / Q000662:veterinary; D005260:Female; D006734:Horse Diseases / Q000139:chemically induced*; D006736:Horses; D010402:Penicillin G Procaine / Q000009:adverse effects* / Q000276:immunology
D010402:Penicillin G Procaine