Cocaine place preference is blocked by the delta-opioid receptor antagonist, naltrindole.
Naltrindole, a selective delta-opioid receptor antagonist, was evaluated for its potential to block the reinforcing properties of cocaine using a conditioned place pairing paradigm in Lewis rats. Cocaine HCl (15 mg/kg s.c.) produced a strong place preference which was significantly blocked in animals pretreated with naltrindole (3 mg/kg i.p.); naltrindole alone showed no reinforcing or aversive effects. The results suggest a novel approach for the treatment of cocaine abuse in man.
Menkens
K
K
Department of Pharmacology, University of Arizona Health Sciences Center, Tucson 85724.
Bilsky
E J
EJ
Wild
K D
KD
Portoghese
P S
PS
Reid
L D
LD
Porreca
F
F
D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D009019:Morphinans / Q000494:pharmacology*; D009271:Naltrexone / Q000031:analogs & derivatives*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D051381:Rats; D011917:Rats, Inbred Lew
D007211:Indoles; D009019:Morphinans; D009292:Narcotic Antagonists; D009271:Naltrexone; C055382:naltrindole; D003042:Cocaine