The presence of free D-serine, D-alanine and D-proline in human plasma.
Twelve neutral free amino acids, i.e. serine, threonine, glutamine, asparagine, alanine, proline, methionine, tyrosine, valine, leucine, isoleucine and phenylalanine, were surveyed for the presence of D-enantiomers in plasma samples from patients with renal diseases and from normal subjects. D-serine, D-alanine and D-proline were found in the patient's plasma. The highest concentrations (D/L ratio) of D-serine, D-alanine and D-proline were 0.2362, 0.2087 and 0.0986, respectively. The sum of the contents of the three D-amino acid was shown to be present in the plasma proteins.
Nagata
Y
Y
Department of Life Science, Himeji Institute of Technology, Japan.
Masui
R
R
Akino
T
T
D000328:Adult; D000368:Aged; D000409:Alanine / Q000097:blood* / Q000302:isolation & purification; D000596:Amino Acids / Q000097:blood* / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011392:Proline / Q000097:blood* / Q000302:isolation & purification; D012016:Reference Values; D012694:Serine / Q000097:blood* / Q000302:isolation & purification; D013237:Stereoisomerism
D000596:Amino Acids; D012694:Serine; D011392:Proline; D003404:Creatinine; D000409:Alanine