title: Comparison of the incidence of intracranial hemorrhage following conventional mechanical ventilation and high frequency oscillation in beagle puppies.
abstract: Controversy exists as to whether high frequency oscillation (HFO) increases the risk of intraventricular hemorrhage (IVH) compared with conventional mechanical ventilation (CMV). We compared the risk of intracranial hemorrhage after phenylephrine-induced hypertension, combined with a hypovolemic, hypotensive insult followed by rapid volume replacement in two groups of newborn beagle puppies (one group on a piston pump HFO and the other on CMV). A total of 12 beagle puppies (6 on HFO and 6 on CMV) survived the protocol. Arterial blood gas analysis and arterial blood pressures through the study were of the same magnitude in both groups. The length of time for which the puppies remained hypertensive and hypotensive also did not vary significantly between the groups. Intraventricular hemorrhages were observed in two of six CMV puppies and two of six HFO puppies. One animal in each group had a white matter hemorrhage. Subarachnoid hemorrhages were seen in 4 animals on CMV and 3 on HFO. This study indicated that HFO does not increase the risk of any kind of intracranial hemorrhage, including IVH, in beagle puppies.
authors.affiliation: University of Tokyo, Department of Pediatrics, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tamura
authors.forename: T
authors.initials: T
authors.lastname: Hishi
authors.forename: T
authors.initials: T
authors.lastname: Ishii
authors.forename: S
authors.initials: S
authors.lastname: Wakita
authors.forename: S
authors.initials: S
authors.lastname: Oho
authors.forename: K
authors.initials: K
authors.lastname: Shibuya
authors.forename: K
authors.initials: K
authors.lastname: Miyasaka
authors.forename: S
authors.initials: S
authors.lastname: Takashima
mesh_terms: D000818:Animals; D002543:Cerebral Hemorrhage / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D004285:Dogs; D005440:Fluid Therapy / Q000009:adverse effects; D006439:Hemodynamics; D006612:High-Frequency Ventilation / Q000009:adverse effects*; D006973:Hypertension / Q000139:chemically induced / Q000150:complications; D015994:Incidence; D010656:Phenylephrine; D012121:Respiration, Artificial / Q000009:adverse effects*; D012307:Risk Factors; D012769:Shock / Q000150:complications
chemical_list: D010656:Phenylephrine