[Lipid peroxidation in the liver microsomes--a sensitive link in body exposure to vat dyes].
Experiments on male white rats showed that the soluble forms of vat dyes such as red brown 'G' (RBG) and bright green 'G' (BGG) delivered into the stomach in a toxic dose (1 g/kg) activate lipid peroxidation (LPO) in liver microsomes. Chronically inhaled dyes hasten of slow down some LPO stages, the changes depending on the concentration, duration of exposure and chemical structure of a compound. Soluble vat dye RBG increases LPO in concentration 5 mg/m3 whereas RBG shows antioxidant action in high and low concentrations.
Pashchenko
E A
EA
Kolodub
F A
FA
Vasilenko
N M
NM
D000818:Animals; D004396:Coloring Agents / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D015227:Lipid Peroxidation / Q000187:drug effects*; D008054:Lipid Peroxides / Q000032:analysis / Q000378:metabolism; D008163:Luminescent Measurements; D008297:Male; D008315:Malondialdehyde / Q000032:analysis / Q000378:metabolism; D008862:Microsomes, Liver / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D009930:Organic Chemicals; D051381:Rats; D013053:Spectrophotometry; D013997:Time Factors
D004396:Coloring Agents; D008054:Lipid Peroxides; D009930:Organic Chemicals; C078063:vat dye bright green G; C078064:vat dye red brown G; D008315:Malondialdehyde
Perekisnoe okislenie lipidov v mikrosomakh pecheni--chuvstvitel'noe zveno vozdeĭstviia na organizm nekotorykh kubovykh krasiteleĭ.