Neurofibromatosis cerebral vasculopathy in an infant: clinical, neuroradiographic, and neuropathologic studies.
An infant with neurofibromatosis developed recurrent cerebrovascular accidents beginning at 3 months of life. Cerebral arteriography demonstrated large-vessel occlusive disease and bilateral severe moyamoya. At autopsy these lesions were apparent on gross examination, and advanced intimal and medial dysplasia was seen on microscopic examination of both the anterior and posterior circulations. Although rare, neurofibromatosis cerebrovasculopathy may occur in young infants and may account for some strokes in this age group.
Woody
R C
RC
Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205.
Perrot
L J
LJ
Beck
S A
SA
D001157:Arterial Occlusive Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male; D009072:Moyamoya Disease / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D017253:Neurofibromatoses / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography