[The effect of gas hypoxia (10% O2) and dextran sulfate on the radiosensitivity of the stem cells of the intestinal epithelium in mice].
Injection of dextran sulphate before irradiation was shown to protect jejunal epithelium stem cells (D0 increased from 1.13 to 1.82 Gy). The protective effect of a combination of dextran sulphate and gas hypoxic mixture (10% O2) did not exceed that of the administration of the gas hypoxic mixture (10% O2) alone.
Konopliannikova
O A
OA
Konopliannikov
A G
AG
Vacek
A
A
Rotkovská
D
D
Bartonicková
A
A
D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D016264:Dextran Sulfate / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004848:Epithelium / Q000187:drug effects / Q000528:radiation effects; D005720:Gamma Rays; D007422:Intestines / Q000187:drug effects* / Q000528:radiation effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009584:Nitrogen / Q000494:pharmacology*; D010100:Oxygen / Q000494:pharmacology*; D011836:Radiation Tolerance; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013234:Stem Cells / Q000187:drug effects* / Q000528:radiation effects; D013997:Time Factors
D011837:Radiation-Protective Agents; C041364:nitrox; D016264:Dextran Sulfate; D009584:Nitrogen; D010100:Oxygen
Vliianie gazovoĭ gipoksii (10% O2) i dekstran-sul'fata na radiochuvstvitel'nost' stvolovykh kletok kishechnogo épiteliia mysheĭ.