Immunoglobulin A nephropathy in a renal allograft of a black transplant recipient.
Although IgA nephropathy (IgA N) is reportedly the most common form of primary glomerulonephritis worldwide, there is a very low incidence of IgA N in Black Americans, and IgA N in Black patients with renal allografts has not been reported. In this report, we present the case of a Black patient with endstage renal disease presumed secondary to hypertensive nephrosclerosis who developed nephrotic range proteinuria due to IgA N in a cadaveric renal allograft 2 years following transplantation. Biopsy of the allograft in the immediate post-transplantation period had revealed no evidence of IgA N. Chronic active hepatitis related to hepatitis C preceded the development of proteinuria by approximately 1 year, raising the possibility that IgA N in the renal allograft was secondary to the liver disease. The clinical and histological features of primary IgA N and IgA N secondary to liver diseases are discussed.
Francisco
S
S
Veterans Affairs Medical Center, Memphis, Tenn.
Wall
B M
BM
Cooke
C R
CR
D044383:Black People; D002102:Cadaver; D005922:Glomerulonephritis, IGA / Q000150:complications* / Q000208:ethnology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology* / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009400:Nephrosclerosis / Q000150:complications; D011507:Proteinuria / Q000209:etiology*; D001741:Black or African American