Transfer of specific IgG and IgG subclasses to herpes simplex virus across the blood-brain barrier and placenta in preterm and term newborns.
The kinetics of virus-specific IgG subclasses (IgG 1-4) among newborns and their mothers has not yet been determined. In this report, we examined anti-herpes simplex virus IgG activities (HSV-IgG) and its subclasses in CSF and serum of premature or term newborns without HSV infection and in the serum of their mothers using ELISA. We found that CSF/serum ratios of HSV-IgG and IgG subclasses (IgG 1-4) in newborns with a gestational age less than 38 weeks were higher than those of term newborns. These findings indicate that the blood-brain barrier against HSV-IgG and IgG subclasses is insufficient in newborns. Furthermore, we found that HSV-IgG subclasses, which were transferred across the placenta and later transferred across the blood-brain barrier had a tendency to be proportional to each of the maternal HSV-IgG subclasses.
Osuga
T
T
Department of Pediatrics and Immunology, Nagoya University School of Medicine, Japan.
Morishima
T
T
Hanada
N
N
Nishikawa
K
K
Isobe
K
K
Watanabe
K
K
D000914:Antibodies, Viral / Q000097:blood / Q000134:cerebrospinal fluid; D001812:Blood-Brain Barrier; D005069:Evaluation Studies as Topic; D005260:Female; D006561:Herpes Simplex / Q000097:blood / Q000134:cerebrospinal fluid / Q000635:transmission*; D006801:Humans; D007074:Immunoglobulin G / Q000145:classification / Q000276:immunology*; D007231:Infant, Newborn / Q000097:blood / Q000134:cerebrospinal fluid; D007234:Infant, Premature / Q000097:blood / Q000134:cerebrospinal fluid; D010920:Placenta; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000134:cerebrospinal fluid
D000914:Antibodies, Viral; D007074:Immunoglobulin G