Construction of a microdialysis probe with attached microinjection catheter.
We describe a microdialysis probe with attached side catheter for making submicroliter injections at the site of the probe in the awake, freely moving rat. This design allows the local application of drugs which cannot be applied in the perfusion medium either because of their inability to pass through the dialysis membrane or because of their interference with chromatographic detection of compounds of interest.
Frothingham
E P
EP
Keck Center for Integrative Neuroscience, University of California, San Francisco 94143.
Basbaum
A I
AI
D000818:Animals; D003956:Dialysis / Q000295:instrumentation*; D008845:Microinjections / Q000295:instrumentation*; D010487:Periaqueductal Gray / Q000502:physiology; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000494:pharmacology
D005680:gamma-Aminobutyric Acid