title: A new carbamazepine metabolite in uraemic filtrate.
abstract: 1. After administration of carbamazepine (Tegretal) to an epileptic patient suffering also from uraemia, a previously unknown metabolite was detected in the haemofiltrate. It was identified as the 10,11-dihydro-10-hydroxy-carbamazepine-O-beta-glucuronide. 2. Its identification was accomplished mainly by electron impact (EI), liquid secondary ion (LSI) mass spectrometry and n.m.r. spectroscopy.
authors.affiliation: Lehrstuhl Organische Chemie I, Universität Bayreuth, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Beyer
authors.forename: G
authors.initials: G
authors.lastname: Spiteller
mesh_terms: D002220:Carbamazepine / Q000378:metabolism*; D005260:Female; D005965:Glucuronates / Q000378:metabolism; D006801:Humans; D013058:Mass Spectrometry; D008875:Middle Aged; D014511:Uremia / Q000378:metabolism*
chemical_list: D005965:Glucuronates; D002220:Carbamazepine