title: Effect of cyclophosphamide immunosuppression on the immunity of turkeys to viral rhinotracheitis.
abstract: Turkey poults, free of antibodies to turkey rhinotracheitis (TRT) virus were treated with cyclophosphamide on days 1, 2 and 3 after hatching and vaccinated by eyedrop when 10 days old with a Vero cell-attenuated preparation of TRT virus. No ELISA antibodies to TRT virus developed in the sera of these poults but they were as resistant to virulent virus challenge 21 days later as vaccinated groups which were not cyclophosphamide-treated but produced humoral antibodies. Following challenge with virulent virus at 31 days old cyclophosphamide-treated unvaccinated poults developed a more severe clinical response than untreated birds and had higher virus titres in tracheal swabs. The findings show that the respiratory tract of turkeys may be resistant to TRT despite the absence of ELISA antibodies in the serum.
authors.affiliation: Department of Veterinary Pathology, University of Liverpool, Neston, Wirral.
authors.forename: R C
authors.initials: RC
authors.lastname: Jones
authors.forename: C J
authors.initials: CJ
authors.lastname: Naylor
authors.forename: A
authors.initials: A
authors.lastname: al-Afaleq
authors.forename: K J
authors.initials: KJ
authors.lastname: Worthington
authors.forename: R
authors.initials: R
authors.lastname: Jones
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology*; D008297:Male; D011201:Poultry Diseases / Q000276:immunology* / Q000382:microbiology; D012141:Respiratory Tract Infections / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D014132:Trachea / Q000382:microbiology; D014422:Turkeys / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology / Q000662:veterinary*
chemical_list: D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines; D003520:Cyclophosphamide