[An assessment of the individual sensitivity of Wistar rats to the development of morphine dependence].
A search was made for behavioral and physiological indicators which could serve predictors of the individual sensitivity of Wistar rats to the development of physical morphine dependence. Animals with high sensitivity to the development of dependence initially demonstrated intensive ambulation and low motor rearing in the "open field" and had low nociception. Stable animals exhibited high ambulation and motor rearing with insignificant grooming activity as compared to other rats. It has been revealed that rats sensitive to the development of dependence demonstrate higher anxiety in the Vogel test as compared to the stable ones. The findings obtained allowed one to derive a number of equations to predict Wistar rats' individual sensitivity to the development of physical morphine dependence.
Konstantinopol'skiĭ
M A
MA
Surkova
L A
LA
Tiurina
I V
IV
Sudakov
S K
SK
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D004558:Electric Stimulation; D004644:Emotions / Q000187:drug effects / Q000502:physiology; D007206:Individuality; D008297:Male; D009020:Morphine / Q000009:adverse effects; D009021:Morphine Dependence / Q000209:etiology / Q000503:physiopathology*; D009270:Naloxone / Q000494:pharmacology; D010146:Pain / Q000503:physiopathology; D011379:Prognosis; D051381:Rats; D017208:Rats, Wistar / Q000502:physiology*; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology
D009270:Naloxone; D009020:Morphine
Otsenka individual'noĭ chuvstvitel'nosti krys linii Vistar k formirovaniiu zavisimosti k morfinu.