Blockade of hyperalgesia and neurogenic oedema by topical application of nitroglycerin.
Surprisingly, a single topical application of a nitroglycerin (NTG) gel in humans has been shown to cause analgesia and to reduce oedema in thrombophlebitis. In the present investigation, we showed that the NTG gel reduces prostaglandin E2-induced hyperalgesia and blocks neurogenic inflammation induced in rat skin by antidromic electrical stimulation of the saphenous nerve. These results offer an explanation for the effects of topical application of NTG observed in thrombophlebitis, which may be common to other cutaneous pathologies. The data also support the development of nitrates the effects of which are restricted to the site of application.
Ferreira
S H
SH
Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, São Paulo, Brazil.
Lorenzetti
B B
BB
Faccioli
L H
LH
D000287:Administration, Topical; D000818:Animals; D015232:Dinoprostone / Q000494:pharmacology; D004487:Edema / Q000188:drug therapy*; D004558:Electric Stimulation; D006930:Hyperalgesia / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D005996:Nitroglycerin / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D009569:Nitric Oxide; D005996:Nitroglycerin; D015232:Dinoprostone