[The reproductive characteristics of the tick-borne encephalitis virus in interspecific somatic hybrids].
The study dealt with features of tick-borne encephalitis virus reproduction in two series of interspecies somatic hybrids generated by fusion of transformed cells of Chinese hamster (Ag17) with human diploid fibroblasts (KM/3) and with pseudonormal cells of Indian deer (Muntiacus munjak) (KOM). The viral infection in hybrid Ag17 cells ran an acute course with cell damage, but in KM/3 and KOM cells virus multiplication was not accompanied by the development of cytopathic effect. Two other parameters of tick-borne encephalitis virus infection under study: the extent of infectious particles production and electroimmunochemical properties were found to be under control of genomes of different parental cells.
Mustafina
A N
AN
Liapustin
V N
VN
Lashkevich
V A
VA
Kakpakova
E S
ES
D000818:Animals; D002461:Cell Line, Transformed; D006224:Cricetinae; D003412:Cricetulus; D003588:Cytopathogenic Effect, Viral; D003670:Deer; D004669:Encephalitis Viruses, Tick-Borne / Q000235:genetics / Q000254:growth & development*; D016679:Genome, Viral; D006801:Humans; D006822:Hybrid Cells / Q000382:microbiology*; D007621:Karyotyping; D010948:Viral Plaque Assay; D014776:Virus Cultivation / Q000379:methods; D014779:Virus Replication
Osobennosti reproduktsii virusa kleshchevogo éntsefalita v mezhvidovykh somaticheskikh gibridakh.