Effects of subcutaneous versus intravenous administration of cyclosporin A on rat thymic histology and pharmacokinetics.
Cyclosporin A (CsA) was administered to rats by repeated subcutaneous (s.c.) or intravenous (i.v.) injections for 14 days. Changes in thymic histology were independent of the route of administration. Blood concentration--time profiles of CsA were similar at dose levels of i.v. 7.5 and s.c. 15 mg/kg/day, respectively. So, provided that the dose is reduced, i.v. injection can serve as an adequate alternative to s.c. injection, thereby preventing unwanted painful side-effects associated with the latter route of administration.
de Waal
E J
EJ
National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.
Schuurman
H J
HJ
Hendriksen
C
C
Elvers
B
B
Van Dijk
A
A
Van Loveren
H
H
D000818:Animals; D016572:Cyclosporine / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008297:Male; D051381:Rats; D013950:Thymus Gland / Q000187:drug effects* / Q000473:pathology
D016572:Cyclosporine