title: [Serum creatine kinase isoenzyme MB and myoglobin in patients with acute myocardial infarction and coronary reperfusion].
abstract: Thrombolytic therapy in patients with acute myocardial infarction (AMI) changes the time-concentration curve of serum creatine kinase isoenzyme MB (CK-MB) and serum myoglobin. In this study, 60 AMI patients received thrombolytic therapy and acute coronary arteriography, or conservative treatment. Group one (n = 32) demonstrated a patent infarct-related artery after intravenous thrombolytic therapy; group two (n = 17) had an initially occluded coronary artery which became patent during catheterisation; group three (n = 11) did not receive thrombolytic therapy. Frequent serum CK-MB and myoglobin measurements showed that patients with acute coronary reperfusion had a rapid increase, an earlier peak value and less total release of both CK-MB and myoglobin to blood compared to AMI patients treated conservatively. The changes in serum myoglobin compared to CK-MB demonstrated an even more rapid, more uniform, and relatively greater increase. Measurements of serum myoglobin may be a useful non-invasive method for evaluation of thrombolytic therapy in AMI patients.
authors.affiliation: Medicinsk afdeling B, Rigshospitalet, København.
authors.forename: B
authors.initials: B
authors.lastname: Jurlander
authors.forename: P M
authors.initials: PM
authors.lastname: Clemmensen
authors.forename: E M
authors.initials: EM
authors.lastname: Ohman
authors.forename: G S
authors.initials: GS
authors.lastname: Wagner
authors.forename: P
authors.initials: P
authors.lastname: Grande
mesh_terms: D000328:Adult; D000368:Aged; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy / Q000201:enzymology*; D015428:Myocardial Reperfusion Injury / Q000097:blood / Q000188:drug therapy / Q000201:enzymology*; D009211:Myoglobin / Q000097:blood*; D015912:Thrombolytic Therapy
chemical_list: D007527:Isoenzymes; D009211:Myoglobin; D003402:Creatine Kinase
vernacular_title: Serum-kreatinkinase isoenzym-MB og -myoglobin hos patienter med akut myokardieinfarkt og koronar reperfusion.