Fibrinolytic activity as a predictor of the outcome of prolapsed intervertebral lumbar disc surgery with reference to background variables: results of a prospective cohort study.
In a prospective study 122 patients with a slipped lumbar disc and no previous surgery were preoperatively examined for fibrinolytic activity. Surgical results for these patients were evaluated 12 months postoperatively by clinical overall assessment. In a multiple linear regression analysis fibrinolytic variables, euglobulin clot lysis time and plasminogen activator inhibitor 1, were shown to have predictive value regarding outcome of surgery; that is, normal fibrinolytic activity favors a satisfactory outcome and vice versa. Background variables and lipid profile were also recorded preoperatively. Body mass index, gamma-glutamyl transpeptidase, triglycerides and smoking were of statistical significance in relation to euglobulin clot lysis time and plasminogen activator inhibitor 1. Postoperative fibrinolytic re-examination of 20 patients seem to confirm that patients at risk of surgical failure have a prolonged depression of fibrinolytic activity.
Haaland
A K
AK
Ullevål University Hospital, Oslo, Norway.
Graver
V
V
Ljunggren
A E
AE
Loeb
M
M
Lie
H
H
Magnaes
B
B
Godal
H C
HC
D015331:Cohort Studies; D005342:Fibrinolysis; D005544:Forecasting; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000097:blood / Q000503:physiopathology / Q000601:surgery*; D008159:Lumbar Vertebrae; D015849:Plasminogen Inactivators / Q000097:blood; D011184:Postoperative Period; D011446:Prospective Studies; D012044:Regression Analysis; D010959:Tissue Plasminogen Activator / Q000097:blood
D015849:Plasminogen Inactivators; D010959:Tissue Plasminogen Activator