title: Cardiodynamic effects of dopamine and dobutamine.
abstract: On 11 patients undergoing coronary surgery, at the end of the surgical intervention, the inotropic responses to 0.4 and 0.8 microgram x kg-1 x min-1 dopamine and dobutamine given via the aorto-coronary bypass directly into the coronary artery were compared. These dosages correspond to ones 10 times greater applied intravenously. The measurements were made using needle force probes which were implanted into the myocardial offstream area in the left ventricular wall. Bypass flow was measured simultaneously by an electromagnetic flow probe. There is a significant increase in coronary bypass flow induced by both rates of 0.4 and 0.8 microgram x kg-1 x min-1 dobutamine, but there was no significant effect on bypass flow induced by dopamine. Developed myocardial force is raised more by dobutamine medication than by dopamine. However, the rate of contraction increases significantly and relaxation is significantly accelerated by dopamine at both dosages. A significant increase in rate of contraction and relaxation was only induced by the higher dosage of 0.8 microgram x kg-1 x min-1 dobutamine.
authors.affiliation: Clinic for Thoracic and Cardiovascular Surgery, University Hospital, Münster.
authors.forename: P P
authors.initials: PP
authors.lastname: Lunkenheimer
authors.forename: K
authors.initials: K
authors.lastname: Redmann
authors.forename: H
authors.initials: H
authors.lastname: Isringhaus
authors.forename: W
authors.initials: W
authors.lastname: Flameng
authors.forename: G
authors.initials: G
authors.lastname: Rettig
authors.forename: W F
authors.initials: WF
authors.lastname: Whimster
mesh_terms: D000368:Aged; D001026:Coronary Artery Bypass; D003326:Coronary Circulation / Q000187:drug effects*; D004280:Dobutamine / Q000494:pharmacology*; D004298:Dopamine / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects*; D011184:Postoperative Period; D013268:Stimulation, Chemical
chemical_list: D004280:Dobutamine; D004298:Dopamine