X-linked pathologic myopia.
We examined a patient with decreased visual acuity and macular changes attributable to pathologic myopia. Thirteen additional family members were examined, and historic information was obtained on their relatives. A pedigree spanning six generations was constructed that demonstrated an X-linked mode of inheritance. This finding has important genetic and therapeutic implications for similarly affected patients.
Gregg
F M
FM
College of Medicine, University of Tennessee, Chattanooga 37404.
Feinberg
E B
EB
D002825:Chorioretinitis / Q000235:genetics; D005654:Fundus Oculi; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000235:genetics*; D010375:Pedigree; D014792:Visual Acuity; D014960:X Chromosome