Transdermal delivery and intramuscular injection of trimethoprim/sulphadiazine in sucking piglets.
The pharmacokinetics of a combination of trimethoprim (TMP) and sulphadiazine (SDZ) after topical application to sucking piglets was compared with the pharmacokinetics after intramuscular injection. A long-lasting and fairly constant SDZ/TMP concentration ratio in plasma was obtained after topical application. The mean plasma concentration of TMP ranged from 0.091 to 0.17 micrograms/ml and that of SDZ from 0.72 to 1.1 micrograms/ml for at least 24 h. TMP and SDZ had different half-lives after intramuscular injection. Transdermal delivery of a combined preparation of TMP/SDZ may be usable for colibacillosis of sucking piglets, although the bioavailability of the drugs is poor.
Sekido
T
T
Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Japan.
Kokue
E
E
Shimoda
M
M
Hayama
T
T
D000279:Administration, Cutaneous; D000818:Animals; D000833:Animals, Suckling / Q000378:metabolism*; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001682:Biological Availability; D004338:Drug Combinations; D006207:Half-Life; D007273:Injections, Intramuscular / Q000662:veterinary; D012869:Skin Absorption; D013411:Sulfadiazine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013552:Swine / Q000378:metabolism*; D014295:Trimethoprim / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000096926:Benzenesulfonamides
D000890:Anti-Infective Agents; D004338:Drug Combinations; D013411:Sulfadiazine; D014295:Trimethoprim; C024873:sulfadiazine, trimethoprim drug combination; D000096926:Benzenesulfonamides