title: Adoptive transfer of experimental autoimmune uveoretinitis in HgCl2 injected rats.
abstract: We previously demonstrated that mercuric chloride (HgCl2) injected-(Lewis x Brown-Norway) F1 rats are protected against experimental autoimmune uveoretinitis (EAU) induced by active immunization with the retinal S-antigen (S-Ag). To better understand the mechanisms of the protection promoted by HgCl2, we studied the effect of HgCl2-induced autoimmune disease on transferred EAU. We demonstrate herein that HgCl2 has no effect on adoptively transferred EAU. Therefore, the HgCl2-induced autoimmune disease does not affect effector S-Ag specific T cells activated in vitro but acts at an earlier stage.
authors.affiliation: Pathologie rénale et vasculaire, INSERM U28, Hôpital Broussais, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Saoudi
authors.forename: B
authors.initials: B
authors.lastname: Bellon
authors.forename: Y
authors.initials: Y
authors.lastname: de Kozak
authors.forename: P
authors.initials: P
authors.lastname: Druet
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology; D019393:Arrestin; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology* / Q000628:therapy; D004195:Disease Models, Animal; D005136:Eye Proteins / Q000276:immunology; D005260:Female; D007073:Immunoglobulin E / Q000032:analysis; D016219:Immunotherapy, Adoptive; D008297:Male; D008627:Mercuric Chloride; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D012173:Retinitis / Q000276:immunology* / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology; D014605:Uveitis / Q000276:immunology* / Q000628:therapy
chemical_list: D000941:Antigens; D019393:Arrestin; D001324:Autoantigens; D005136:Eye Proteins; D007073:Immunoglobulin E; D008627:Mercuric Chloride