Synthesis and biological activity of new 1,8-diaza-2,9,10-anthracenetrione derivatives.
Diels-Alder heterocycloaddition reactions of 2,5,8-quinolinetriones and 1-azadienes afford 1,8-diaza-2,9,10-anthracenetriones, which are simple analogues of the antitumoral antibiotic diazaquinomicin A. Cytotoxicity in this series and antitumor activity of the lead compound, 6-methyl-1,8-diaza-2,9,10-anthracenetrione, are reported.
Gesto
C
C
Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
de la Cuesta
E
E
Avendaño
C
C
Emling
F
F
D000873:Anthracenes / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D011809:Quinones / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000873:Anthracenes; D000970:Antineoplastic Agents; D011809:Quinones; C046688:diazaquinomycin A