title: Complex translocation involving Ph chromosome in a patient with typical chronic myelogenous leukemia.
abstract: We report a cytogenetic study of a patient with chronic myelogenous leukemia (CML) who, while displaying a Philadelphia (Ph) chromosome, resulting from a standard t(9;22) at diagnosis, during the chronic phase (CP) showed disappearance of the Ph and occurrence of new chromosome changes, including a marker probably arising from a translocation involving chromosome 17 and the Ph. In situ hybridization confirmed the cytogenetic appearance and demonstrated that the breakpoint on the Ph marker occurred below the BCR-ABL fusion gene.
authors.affiliation: Institute of Biology and Genetics, University of Chieti, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Calabrese
authors.forename: G
authors.initials: G
authors.lastname: Palka
authors.forename: C A
authors.initials: CA
authors.lastname: Westbrook
authors.forename: D
authors.initials: D
authors.lastname: Sheer
mesh_terms: D002872:Chromosome Deletion; D002886:Chromosomes, Human, Pair 17; D002887:Chromosomes, Human, Pair 18; D002897:Chromosomes, Human, Pair 7; D002899:Chromosomes, Human, Pair 9; D005260:Female; D006801:Humans; D017403:In Situ Hybridization; D015466:Leukemia, Myeloid, Chronic-Phase / Q000235:genetics*; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic