Interleukin 2 receptor membrane bound and in soluble form in the aqueous humor and peripheral blood of patients with acute untreated uveitis.
Uveitis is a manifestation of various chronic inflammatory arthritic conditions. There are considerable data implicating abnormalities of immune function in the etiopathogenesis of uveitis. We evaluated the percentage of cells expressing interleukin 2 (IL-2) receptor (membrane bound) and the levels of soluble IL-2 in the blood and aqueous humor of patients in various rheumatic diseases and acute untreated uveitis. Our findings showed increased IL-2 receptors (IL-2R) and soluble IL-2 receptors on the aqueous humor of patients with uveitis when compared to healthy controls. These results suggest an immunoregulatory role of IL-2R in acute uveitis and raises the possibility that its detection may be useful in management.
Scheinberg
M A
MA
Department of Rheumatology/Immunology, Cancer Institute Arnaldo Vieira de Carvalho, São Paulo, Brazil.
Ikejiri
M
M
Silva
M H
MH
Mota
I M
IM
D001082:Aqueous Humor / Q000737:chemistry*; D004797:Enzyme-Linked Immunosorbent Assay; D005455:Fluorescent Antibody Technique; D006801:Humans; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D012995:Solubility; D013601:T-Lymphocytes / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure; D014605:Uveitis / Q000097:blood / Q000378:metabolism* / Q000473:pathology
D015375:Receptors, Interleukin-2