title: Left ventricular filling abnormalities in non-insulin-dependent diabetes mellitus and improvement by a short-term glycemic control.
abstract: To determine whether left ventricular (LV) filling abnormalities in diabetes are associated with diabetic microangiopathy, and to evaluate the effect of a short-term glycemic control on the filling abnormalities, diastolic filling dynamics were assessed by pulsed Doppler echocardiography in 246 patients with non-insulin-dependent diabetics. Isovolumic relaxation time and the ratio of peak flow velocity of atrial filling wave to peak flow velocity of early filling wave (A/E) were significantly greater in diabetic patients than in age- and sex-matched control subjects. Diabetic patients with retinopathy had significantly greater isovolumic relaxation time and A/E values than those without retinopathy. A/E was significantly decreased 1 month after insulin treatment in those without, but not with retinopathy. It is concluded that LV diastolic filling is impaired in mildly hyperglycemic patients with non-insulin-dependent diabetes mellitus without severe complications, the abnormality being more intense in patients with retinopathy. A short-term glycemic control results in a marked decrease in abnormalities in patients without, but not with retinopathy.
authors.affiliation: Department of Geriatrics, Endocrinology and Metabolism, School of Medicine, Shinshu University, Nagano-ken, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hiramatsu
authors.forename: N
authors.initials: N
authors.lastname: Ohara
authors.forename: S
authors.initials: S
authors.lastname: Shigematsu
authors.forename: T
authors.initials: T
authors.lastname: Aizawa
authors.forename: F
authors.initials: F
authors.lastname: Ishihara
authors.forename: A
authors.initials: A
authors.lastname: Niwa
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: M
authors.initials: M
authors.lastname: Naka
authors.forename: A
authors.initials: A
authors.lastname: Momose
authors.forename: K
authors.initials: K
authors.lastname: Yoshizawa
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001783:Blood Flow Velocity / Q000502:physiology; D016009:Chi-Square Distribution; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D003930:Diabetic Retinopathy / Q000000981:diagnostic imaging / Q000503:physiopathology; D003971:Diastole; D004452:Echocardiography / Q000379:methods; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D007328:Insulin