[Disorders of bone marrow hematopoiesis long time after the action of cytostatic preparations].
We studied the condition of CBA mice bone marrow hemopoiesis and functional activity of adherent cells 6 months after a single treatment with vinblastine (VB), doxorubicin (DR) and cyclophosphamide (CP) in LD10 dose (6, 22 and 250 mg/kg, respectively). There was a long-term disorganization of bone marrow cell composition. The damage may be attributed to exhaustion of the pools of stem cells and changes in function of the cells formed by hemopoiesis induction microenvironment.
Bogdashin
I V
IV
Sycheva
E V
EV
Zhdanov
V V
VV
Afanas'eva
O N
ON
Zapuskalova
O P
OP
Novitskiĭ
V V
VV
Gol'dberg
E D
ED
D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001853:Bone Marrow / Q000187:drug effects*; D003520:Cyclophosphamide / Q000009:adverse effects; D004317:Doxorubicin / Q000009:adverse effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013997:Time Factors; D014747:Vinblastine / Q000009:adverse effects
D000970:Antineoplastic Agents; D014747:Vinblastine; D004317:Doxorubicin; D003520:Cyclophosphamide
Narushenie kostnomozgovogo krovetvoreniia v otdalennye sroki posle deĭstviia tsitostaticheskikh preparatov.