Hydrolysis of phosphate monoesters: a biological problem with multiple chemical solutions.
Formation of phosphate esters by kinases has long been recognized as an important process in biochemistry, but the reverse reaction, hydrolysis of phosphate esters by phosphatases, has attracted less attention. Recent work suggests that phosphatases are as important as kinases in regulatory processes, and that they constitute a diverse group of enzymes that utilize a variety of chemical means to accelerate phosphate ester hydrolysis.
Vincent
J B
JB
Department of Chemistry, University of Alabama, Tuscaloosa 35487.
Crowder
M W
MW
Averill
B A
BA
D000135:Acid Phosphatase / Q000737:chemistry / Q000502:physiology; D000469:Alkaline Phosphatase / Q000737:chemistry / Q000502:physiology; D000818:Animals; D004952:Esters / Q000737:chemistry*; D006868:Hydrolysis; D008667:Metalloproteins / Q000502:physiology; D010710:Phosphates / Q000737:chemistry*
D004952:Esters; D008667:Metalloproteins; D010710:Phosphates; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase