title: Microradiographic and histochemical evaluation of mineralization inhibition at the bone-alumina interface.
abstract: Microradiographic and histochemical tests were used to examine the behaviour of the bone tissue close to the alumina coating in cementless hip prostheses which were radiologically stable and explanted because of pain. The presence was detected of a decalcification stripe of the bone tissue with a thickness of about 300 microns, parallel to the prosthesis profile and in appearance not influenced by the roughness of the surface. This phenomenon was attributed to the presence of aluminium ions similarly to what happens in osteomalacic osteodystrophy in nephropathic dialysed patients. It was concluded that the phenomenon must be carefully considered because, in the long term, it could cause failure in the alumina coating.
authors.affiliation: Laboratory for Biocompatibility Research on Implant Materials, University of Bologna, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Stea
authors.forename: L
authors.initials: L
authors.lastname: Savarino
authors.forename: A
authors.initials: A
authors.lastname: Toni
authors.forename: A
authors.initials: A
authors.lastname: Sudanese
authors.forename: A
authors.initials: A
authors.lastname: Giunti
authors.forename: A
authors.initials: A
authors.lastname: Pizzoferrato
mesh_terms: D000535:Aluminum / Q000032:analysis; D000537:Aluminum Oxide / Q000032:analysis; D001842:Bone and Bones / Q000737:chemistry* / Q000000981:diagnostic imaging; D002113:Calcification, Physiologic / Q000187:drug effects*; D005069:Evaluation Studies as Topic; D006622:Hip Prosthesis; D006651:Histocytochemistry; D006801:Humans; D019736:Prostheses and Implants; D011859:Radiography
chemical_list: D000535:Aluminum; D000537:Aluminum Oxide