Thromboxane synthase inhibition in allergen challenged sheep lung: effect on eicosanoid synthesis.
We determined the effect of a novel inhibitor of thromboxane synthase, DP1904, on the baseline and allergen stimulated release of eicosanoids into the bronchoalveolar lavage fluid of sheep. DP1904 was effective in reducing the baseline and allergen stimulated production of TXB2. Inhibition of thromboxane synthase was associated with an increase in other prostaglandin endoperoxide metabolites, PGE2 and PGD2. Diversion of endoperoxide metabolism occurs in sheep lung tissue in vivo.
Dworski
R
R
Department of Medicine, Vanderbilt University, Nashville, TN 37232.
FitzGerald
G A
GA
Sheller
J R
JR
D000485:Allergens; D000818:Animals; D015777:Eicosanoids / Q000096:biosynthesis* / Q000378:metabolism; D007093:Imidazoles / Q000494:pharmacology*; D008168:Lung / Q000201:enzymology* / Q000276:immunology; D012756:Sheep; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*
D000485:Allergens; D015777:Eicosanoids; D007093:Imidazoles; D013764:Tetrahydronaphthalenes; C056295:nafagrel; D013930:Thromboxane-A Synthase