Bacterial acetylation of 5-aminosalicylic acid in faecal suspensions cultured under aerobic and anaerobic conditions.
After oral administration of 5-aminosalicylic acid a substantial proportion of the acetylated form is excreted in the faeces. We have studied the role of the faecal microflora in acetylating 5-aminosalicylic acid. In faeces incubated under both aerobic and anaerobic conditions there was acetylation of 5-aminosalicylic acid. Of the anaerobic bacteria isolated from a 10(8) faecal dilution 44% were able to acetylate 5-aminosalicylic acid. We conclude that the normal faecal microflora contribute to the acetylation of 5-aminosalicylic acid.
van Hogezand
R A
RA
Department of Medicine, St. Radboud Hospital, Nijmegen, The Netherlands.
Kennis
H M
HM
van Schaik
A
A
Koopman
J P
JP
van Hees
P A
PA
van Tongeren
J H
JH
D000107:Acetylation; D000332:Aerobiosis; D000636:Aminosalicylic Acids / Q000378:metabolism*; D000693:Anaerobiosis; D001419:Bacteria / Q000378:metabolism*; D001431:Bacteriological Techniques; D005243:Feces / Q000382:microbiology*; D006801:Humans; D019804:Mesalamine
D000636:Aminosalicylic Acids; D019804:Mesalamine