Determination of 9-hydroxyellipticine by redox colorimetry.
The chemical reactions involved in the decomposition of 9-hydroxyellipticine (9-OH-E), an anticancer agent, in polar solvents is explained. The reactions, which involve the formation of 9-oxo-ellipticine and the addition of a nucleophilic acid on the C10 site of the heterocyclic system, have been used to measure 9-OH-E quantitatively by colorimetry in solution and by reflection on paper surfaces. A method for the stabilization of 9-OH-E in polar solvents is proposed.
Formisyn
P
P
Ecole des Mines de Saint-Etienne, Laboratoire de Génie industriel & Biotechnologie, France.
Pautet
F
F
Tran Minh
C
C
Bourgois
J
J
D000970:Antineoplastic Agents / Q000032:analysis* / Q000737:chemistry; D002855:Chromatography, Thin Layer / Q000379:methods; D003124:Colorimetry / Q000379:methods; D004611:Ellipticines / Q000032:analysis* / Q000737:chemistry; D010084:Oxidation-Reduction
D000970:Antineoplastic Agents; D004611:Ellipticines; C008009:9-hydroxyellipticine