Deferoxamine (Desferal) improves the content of oxygen in myocardial tissues during recovery after hypoxia in isolated rabbit heart.
On isolated working right heart from rabbit tissue oxygen content as an indicator of function of oxygen transport and storage was observed by moderate hypoxia, hypoxia with deferoxamine (1) and iron infusion. In addition water content of myocardium as an indicator of metabolic damage was evaluated and the copper depletion was established. During the recovery the results presented a beneficial effect on the content of tissue oxygen which is due to 1. But the copper depletion was not changed. Possible connections are discussed.
Jacobsohn
E
E
Institute of Drug Research Berlin.
Löwe
H
H
D000818:Animals; D001834:Body Water / Q000378:metabolism; D003300:Copper / Q000378:metabolism; D003676:Deferoxamine / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D000860:Hypoxia / Q000378:metabolism*; D066298:In Vitro Techniques; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D011817:Rabbits
D003300:Copper; D003676:Deferoxamine