Application of a pharmacokinetic model with multiple enterohepatic cycles to a new inotropic drug after infusion and oral administration.
A pharmacokinetic model with multiple, unequal, enterohepatic recirculations was developed to fit the experimental data of a new inotropic drug after intravenous infusion and oral administration. Optimized model parameters were used to derive theoretical values of the area under the curves of concentration versus time that were in good agreement with the experimental values.
Plusquellec
Y
Y
UFR de Mathématiques, Université Paul Sabatier, Toulouse, France.
Barre
J
J
de Biasi
J
J
Trenque
T
T
Tillement
J P
JP
Houin
G
G
D000284:Administration, Oral; D000328:Adult; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002317:Cardiovascular Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004764:Enterohepatic Circulation / Q000502:physiology*; D006801:Humans; D007262:Infusions, Intravenous; D007408:Intestinal Absorption; D008297:Male; D008954:Models, Biological; D010879:Piperazines / Q000008:administration & dosage / Q000493:pharmacokinetics*
D002316:Cardiotonic Agents; D002317:Cardiovascular Agents; D010879:Piperazines; C059182:N,N'-dicyclopropylmethylpiperazine