title: The cell cycle then and now.
abstract: In the last few years a general model of cell cycle control has been established for all eukaryotic cells. Experiments from a variety of organisms and from a variety of experimental approaches have identified a protein kinase and its unstable regulatory subunit as the activator of mitosis; related molecules seem to be involved in the activation of chromosome replication. The identification of the biochemical components of these important regulatory pathways is providing several new insights into homeostatic and developmental control mechanisms in higher organisms.
authors.affiliation: School of Medicine, Department of Biochemistry and Biophysics, San Francisco, CA 94143-0448.
authors.forename: M
authors.initials: M
authors.lastname: Kirschner
mesh_terms: D000818:Animals; D016203:CDC2 Protein Kinase / Q000502:physiology; D002453:Cell Cycle / Q000502:physiology*; D002455:Cell Division / Q000502:physiology; D016213:Cyclins / Q000502:physiology; D004261:DNA Replication; D016200:Maturation-Promoting Factor / Q000502:physiology; D008938:Mitosis / Q000502:physiology
chemical_list: D016213:Cyclins; D016203:CDC2 Protein Kinase; D016200:Maturation-Promoting Factor