title: Dose-response relationships in carcinogenesis.
abstract: Considerable information on the carcinogenic potential of chemical and radiological agents has accumulated from the epidemiological and toxicological studies conducted to date. In this article, we discuss dose-response relationships in carcinogenesis from both empirical and theoretical points of view. Emphasis is placed on the application of biologically based models to describe observed dose-response relationships for exposure to single and multiple agents known to increase cancer risk. The implications of these observations for inferences about possible mechanisms of carcinogenesis are explored.
authors.affiliation: Health Protection Branch, Health and Welfare Canada, Ottawa, Ontario.
authors.forename: D
authors.initials: D
authors.lastname: Krewski
authors.forename: M J
authors.initials: MJ
authors.lastname: Goddard
authors.forename: J M
authors.initials: JM
authors.lastname: Zielinski
mesh_terms: D000818:Animals; D002273:Carcinogens / Q000008:administration & dosage* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D009369:Neoplasms / Q000139:chemically induced*; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D011829:Radiation Dosage
chemical_list: D002273:Carcinogens