[X-ray diffraction studies on tolbutamide solid dispersion].
D860 (tolbutamide) solid dispersions prepared with urea, polyvinyl pyrrolidone (PVP), and polyethylene glycal (PEG) 6000 as carriers were studied by X-ray diffraction, relating to their dissolution rates. D860 in D860-PVP dispersion was shown to be in an amorphous state and to have greater dissolution rate. D860-urea and D860-PEG melts were found to be partly in miscible solid solution state and partly in microcrystal state and possess higher activity and greater dissolution rate. D860-PEG coprecipitate was a physical mixture and its dissolution rate is slower than its melt. No variation in the crystal structure of the D860 dispersions was observed during the ageing test.
Ma
X
X
Department of Pharmacy, Lanzhou Medical College.
Rong
S K
SK
Wu
Q Q
QQ
Zhou
G X
GX
D004337:Drug Carriers; D011092:Polyethylene Glycols; D011205:Povidone; D014044:Tolbutamide / Q000737:chemistry*; D014508:Urea; D014961:X-Ray Diffraction
D004337:Drug Carriers; D011092:Polyethylene Glycols; D014508:Urea; D014044:Tolbutamide; D011205:Povidone