Increase of serotonin in plasma during onset of halothane-induced malignant hyperthermia in pigs.
The levels of serotonin (5-HT) were determined in platelet-free and platelet-rich plasma before and during the onset of halothane-induced malignant hyperthermia (MH) in genetically MH-susceptible pigs. During MH onset, the free (i.e. physiologically active) levels of 5-HT in plasma rose concomitantly with the increases in muscle tone, body temperature, venous pCO2 and plasma lactate. Since pharmacological stimulation of 5-HT2 receptors has recently been shown to trigger MH in susceptible pigs, the finding of increased 5-HT plasma levels during onset of halothane-induced MH may indicate that 5-HT is involved in the mechanisms by which volatile anesthetics trigger this myopathic syndrome.
Gerdes
C
C
Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany.
Richter
A
A
Annies
R
R
Löscher
W
W
D000818:Animals; D001831:Body Temperature; D005260:Female; D006221:Halothane; D006439:Hemodynamics; D008297:Male; D008305:Malignant Hyperthermia / Q000097:blood* / Q000503:physiopathology; D012701:Serotonin / Q000097:blood*; D013552:Swine
D012701:Serotonin; D006221:Halothane