title: Apomorphine disrupts odour-induced patterns of glomerular activation in the olfactory bulb.
abstract: The olfactory bulb of adult male rats stimulated with propionic acid vapours displays a characteristic focus of high metabolic activity in the dorso-medial glomeruli, as revealed by the 2-deoxyglucose (2DG) method. Injection of the dopaminergic agonist apomorphine (1.5 mg kg-1) prior to odour stimulation completely abolishes this selective pattern of glomerular activation, while the metabolic activity of other bulbar areas is not significantly altered. This effect is abolished by a previous injection of the dopamine antagonist haloperidol (0.1 mg kg-1). These observations emphasize the probable involvement of dopamine and dopamine receptors in the bulbar processing of olfactory information.
authors.affiliation: Physiologie neurosensorielle, CNRS, Université Claude Bernard/Lyon, Villeurbanne, France.
authors.forename: M
authors.initials: M
authors.lastname: Sallaz
authors.forename: F
authors.initials: F
authors.lastname: Jourdan
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D003847:Deoxyglucose; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D009830:Olfactory Bulb / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D011422:Propionates / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012903:Smell / Q000187:drug effects*
chemical_list: D011422:Propionates; D003847:Deoxyglucose; D006220:Haloperidol; D001058:Apomorphine