Reversal of food restriction-induced inhibition of mouse skin tumor promotion by adrenalectomy.
Restricting the food intake of laboratory mice and rats markedly reduces the incidence of spontaneous and experimentally induced cancers. Using the two-stage skin tumorigenesis model in CD-1 mice, we report now that food restriction suppresses 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation of epidermal [3H]thymidine incorporation as well as TPA promotion of skin papillomas, whereas adrenalectomy completely reverses the inhibition in [3H]thymidine incorporation and tumor development. These results suggest that the adrenal gland may play an important role in mediating the tumor inhibitory effect of food restriction.
Pashko
L L
LL
Feis Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140.
Schwartz
A G
AG
D000311:Adrenal Glands / Q000502:physiology / Q000601:surgery; D000315:Adrenalectomy; D000818:Animals; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D003345:Corticosterone / Q000097:blood; D004273:DNA, Neoplasm / Q000096:biosynthesis; D003687:Dehydroepiandrosterone / Q000494:pharmacology; D005260:Female; D005502:Food; D051379:Mice; D008815:Mice, Inbred Strains; D010212:Papilloma / Q000139:chemically induced / Q000178:diet therapy*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000178:diet therapy* / Q000209:etiology; D013268:Stimulation, Chemical; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D004273:DNA, Neoplasm; D003687:Dehydroepiandrosterone; D013755:Tetradecanoylphorbol Acetate; D003345:Corticosterone