Kinin generation following methacholine nasal airway challenge of non-allergic subjects.
Following nasal challenges with the muscarinic neurotransmitter methacholine in 14 patients with chronic non-allergic rhinitis, kinin generation was induced. This occurrence was inhibited by pretreatment with anticholinergic agents (ipratropium bromide) and by an overdose of neurotransmitter, indicating that a muscarinic receptor is stimulating the liberation of kinin. These observations suggest that patients with chronic non-allergic rhinitis exhibit cholinergic neurotransmitter-induced kinin generation.
Baumgarten
C R
CR
Department of Clinical Immunology, Free University of Berlin, Federal Republic of Germany.
Niemz
W
W
Kunkel
G
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D006801:Humans; D009241:Ipratropium / Q000494:pharmacology; D007705:Kinins / Q000096:biosynthesis*; D008297:Male; D016210:Methacholine Chloride / Q000494:pharmacology*; D008875:Middle Aged; D009297:Nasal Mucosa / Q000378:metabolism; D009299:Nasal Provocation Tests; D012130:Respiratory Hypersensitivity / Q000378:metabolism; D012220:Rhinitis / Q000378:metabolism*
D007705:Kinins; D016210:Methacholine Chloride; D009241:Ipratropium