Effect of 2,5-hexanedione and 3,4-dimethyl-2,5-hexanedione on retrograde axonal transport in sciatic nerve.
The effects of systemically introduced neurotoxic solvents 2,5-hexanedione (2,5-HD) and 3,4-dimethyl-2,5-hexanedione (DMHD) on retrograde axonal transport (RT) of 125I-labeled tetanus toxin (TT) was studied in rat and mouse sciatic nerves. The rate of retrograde transport of TT in control rat sciatic nerves was slightly higher (6.8 +/- 0.4 mm/h) than in mouse sciatic nerves (5.4 +/- 0.5 mm/h). A single high dose of 2,5-HD (1,000 mg/kg, i.p.) produced a time-dependent effect on RT in mouse sciatic nerves. 2,5-HD caused a gradual decrease in the velocity of RT (approximately 65% inhibition between 2.0-2.5 h) with a reversal to normal rate 3-5 h after the toxin administration. The effect of DMHD on RT was examined following semi-chronic treatment in rats. DMHD caused a significant decrease (approximately 50%) in the rate of TT transport, in addition, it produced weight loss and hind-limb paralysis.
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Center For Research On Occupational And Environmental Toxicology, Oregon Health Sciences University Portland 97201-3098.
D000818:Animals; D001369:Axons / Q000187:drug effects* / Q000378:metabolism; D001692:Biological Transport / Q000187:drug effects; D006588:Hexanones / Q000494:pharmacology*; D007457:Iodine Radioisotopes; D008297:Male; D051379:Mice; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000187:drug effects* / Q000378:metabolism
D006588:Hexanones; D007457:Iodine Radioisotopes; C039195:3,4-dimethyl-2,5-hexanedione; C011269:2,5-hexanedione