[Role of the sympathetic nervous system in the formation of indomethacin-induced hemorrhage and ulceration of the stomach in albino rats].
The authors studied changes of electrical activity of the gastroduodenal smooth muscles, sympathetic efferent impulses in the postganglionic branches of the celiac plexus and macro-morphology of the gastric mucosa during the development of indomethacin gastropathies. By the end of the 3rd hour and later after the injection of the drug (15, 30 mg/kg) progressive inhibition of impulses and basal rhythm of gastric smooth muscles was encountered in intensified electrical activity of the duodenal smooth muscles, as well as destructions in the gastric mucosa even to the development of ulcers (6-24 hours). It is concluded that the development of indomethacin hemorrhages and ulcerations along with other factors is caused by excitation of the sympathetic nervous system attended by phasic changes of the sympathetic efferent impulses and electrical activity of the gastroduodenal zone.
Sergeev
V A
VA
Levskovets
V S
VS
D000818:Animals; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000503:physiopathology*; D007213:Indomethacin / Q000633:toxicity*; D008297:Male; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000503:physiopathology*; D013564:Sympathetic Nervous System / Q000502:physiology*
D007213:Indomethacin
Ob uchastii simpaticheskoĭ nervnoĭ sistemy v obrazovanii indometatsinovykh gemorragiĭ i iz"iazvleniĭ zheludka belykh krys.