Anticarcinogenic effects of (-)-epigallocatechin gallate.
BACKGROUND
Our research objective is to develop nontoxic cancer chemopreventive agents and to apply these agents in treating humans. We are identifying agents that inhibit the process of tumor promotion in two-stage carcinogenesis experiments on mouse skin.


METHODS
We review (a) the inhibitory effect of penta-O-galloyl-beta-D-glucose (5GG) on tumor promotion by teleocidin, one of the 12-O-tetradecanoylphorbol-13-acetate (TPA)-type tumor promoters (5GG is structurally similar to (-)-epigallocatechin gallate (EGCG) and is isolated from hydrolyzed tannic acid); (b) the inhibitory effects of EGCG, the main constituent of Japanese green tea, on tumor promotion with two tumor promoters, teleocidin and okadaic acid, a non-TPA-type tumor promoter; (c) the mechanisms of action of EGCG, a single application of which reduced the specific binding of [3H]TPA and [3H]okadaic acid to a particulate fraction of mouse skin; and (d) the anticarcinogenic effects of EGCG on duodenal carcinogenesis induced by N-ethyl-N'-nitro-N-nitrosoguanidine in male C57BL/6 mice. EGCG is a nontoxic compound.


CONCLUSIONS
We believe that the main constituent of Japanese green tea, EGCG, is a practical cancer chemopreventive agent available in everyday life.
Fujiki
H
H
Cancer Prevention Division, National Cancer Center Research Institute, Tokyo, Japan.
Yoshizawa
S
S
Horiuchi
T
T
Suganuma
M
M
Yatsunami
J
J
Nishiwaki
S
S
Okabe
S
S
Nishiwaki-Matsushima
R
R
Okuda
T
T
Sugimura
T
T
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D047348:Hydrolyzable Tannins; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012878:Skin Neoplasms / Q000378:metabolism / Q000517:prevention & control*; D013634:Tannins / Q000494:pharmacology* / Q000627:therapeutic use; D013662:Tea; D013755:Tetradecanoylphorbol Acetate / Q000031:analogs & derivatives / Q000378:metabolism
D016588:Anticarcinogenic Agents; D047348:Hydrolyzable Tannins; D013634:Tannins; D013662:Tea; C435084:pentagalloylglucose; C032975:12-O-tetradeca-2,4,6,8-tetranoylphorbol-13-acetate; D002392:Catechin; C045651:epigallocatechin gallate; D013755:Tetradecanoylphorbol Acetate