Splanchnic haemodynamic effects of ketanserin in anaesthetized cirrhotic rats.
The effects of ketanserin, atenolol and their association on portal vein pressure (PVP), portal and caval bile acid concentrations (PBA and CBA), and extraction ratio of bile acids (ER) after oral loading with chenodeoxycholic acid were investigated in anaesthetized cirrhotic rats. PVP was significantly reduced by ketanserin and by the association ketanserin plus atenolol; PBA was significantly decreased in all the treated groups, whereas the reduction of CBA was significant only in the rats treated with ketanserin and atenolol alone. ER was increased by atenolol and ketanserin, but it was not modified by their association. Moreover, a significant correlation was observed between PBA and CBA and between PVP and ER. These results suggest that, in anaesthetized cirrhotic rats, ketanserin reduces PVP probably through more complex mechanisms than the simple indirect reduction of portal flow, and that the association of ketanserin plus atenolol has no additive effect in reducing PVP.
Ghia
M
M
Institute of Pharmacology, University of Genoa, Italy.
Mereto
E
E
Mattioli
F
F
Dagnino
F
F
Testa
R
R
D000818:Animals; D001262:Atenolol / Q000494:pharmacology; D001647:Bile Acids and Salts / Q000378:metabolism; D001794:Blood Pressure; D002251:Carbon Tetrachloride; D002635:Chenodeoxycholic Acid / Q000008:administration & dosage; D006439:Hemodynamics / Q000187:drug effects; D007650:Ketanserin / Q000494:pharmacology*; D008106:Liver Cirrhosis, Experimental / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013152:Splanchnic Circulation / Q000187:drug effects*
D001647:Bile Acids and Salts; D002635:Chenodeoxycholic Acid; D001262:Atenolol; D007650:Ketanserin; D002251:Carbon Tetrachloride