Acral persistent papular mucinosis and IgA monoclonal gammopathy: report of a case.
The case of a 60-year-old man with acral persistent papular mucinosis (APPM), thought to represent a new distinctive form of dermal mucinosis not associated with systemic diseases, is reported. The patient had a 4-year history of multiple small papular lesions on the distal forearms, wrists and back of the hands. Histologically, mucin deposits in the upper and mid dermis sparing a superficial subepidermal grenz zone were observed. In contrast to previously described cases, a monoclonal IgA of kappa light chain isotype was detected. Our findings challenge the view that absence of paraproteinemia is a peculiar characteristic of APPM and raise once more the question of its relationship to the discrete papular form of lichen myxedematosus.
Borradori
L
L
Clinique des Maladies Cutanées, CHU Saint-Louis, Paris, France.
Aractingi
S
S
Blanc
F
F
Verola
O
O
Dubertret
L
L
D003937:Diagnosis, Differential; D005542:Forearm / Q000473:pathology; D006229:Hand Dermatoses / Q000150:complications* / Q000473:pathology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007145:Immunoglobulin kappa-Chains / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D017520:Mucinoses / Q000150:complications* / Q000473:pathology; D010265:Paraproteinemias / Q000150:complications*; D014953:Wrist / Q000473:pathology
D007070:Immunoglobulin A; D007145:Immunoglobulin kappa-Chains