title: Increase of brain endogenous monoamine oxidase inhibitory activity (tribulin) in experimental audiogenic seizures in rats: evidence for a monoamine oxidase A inhibiting component of tribulin.
abstract: Brain tribulin activity in rats with an inherited predisposition to audiogenic epilepsy was studied after seizures of different intensity were induced by an electric bell. Weak seizures (from 0 to 2 arbitrary units) did not produce any changes in endogenous inhibitory activity towards either monoamine oxidase (MAO) A or B. Moderate seizures were characterized by increases in both MAO A and MAO B inhibitory activity (up to 1.9-fold). Complete tonic epileptiform seizures with total areflexia (4 arbitrary units) induced further augmentation (up to 2.5-fold) of MAO A but not of MAO B inhibitory activity. This dissociation between the two inhibitory activities points to the existence of a separate MAO A-inhibiting component of brain tribulin which is different from isatin.
authors.affiliation: Institute of Biological and Medical Chemistry, Academy of Medical Sciences, Moscow, Russia.
authors.forename: A E
authors.initials: AE
authors.lastname: Medvedev
authors.forename: V Z
authors.initials: VZ
authors.lastname: Gorkin
authors.forename: I B
authors.initials: IB
authors.lastname: Fedotova
authors.forename: A F
authors.initials: AF
authors.lastname: Semiokhina
authors.forename: V
authors.initials: V
authors.lastname: Glover
authors.forename: M
authors.initials: M
authors.lastname: Sandler
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D007510:Isatin / Q000378:metabolism; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics*; D017208:Rats, Wistar; D012640:Seizures / Q000235:genetics / Q000378:metabolism*
chemical_list: D008996:Monoamine Oxidase Inhibitors; D007510:Isatin; C039776:tribulin; D008995:Monoamine Oxidase