[Mechanisms of the protective action of neoton in immune heart diseases].
An attempt was made to reveal some membrane mechanisms of the protective effect of phosphocreatine (Neoton produced by the Schiappare firm, injected intravenously in a dose of 500 mg/kg) predominantly on the endothelium of the coronary vessels and the cardiomyocytes. Local immune damage to the left-ventricular myocardium was produced by intracoronary injection of anticardiac antibodies. Morphological and biochemical studies showed damage to the membrane of endotheliocytes and cardiomyocytes: reduced activity of Na-Cametabolism and Na-, K-ATPase. The obtained data bore evidence of the protective effect of phosphocreatine in immune damage to the heart, which was realized on the level of the endotheliocyte and cardiomyocyte membranes.
Moĭbenko
A A
AA
Marchenko
G I
GI
Popovich
L F
LF
Cherednichenko
G A
GA
D000818:Animals; D009202:Cardiomyopathies / Q000276:immunology / Q000517:prevention & control*; D004285:Dogs; D005260:Female; D008297:Male; D010725:Phosphocreatine / Q000494:pharmacology*
D010725:Phosphocreatine
Mekhanizmy zashchitnogo deĭstviia neotona pri immunnom povrezhdenii serdtsa.