[Incorporation of an antineoplastic drug aclarubicin into liposomes in relation to the conditions of its encapsulation].
The results of liposome drug encapsulation of aclarubicin (aclacinomycin A), an antitumor antibiotic, are presented. The method of flow detergent dialysis was applied. Conditions providing maximum encapsulation of aclarubicin (the ratio of lipid components and the lipid/detergent ratio), as well as conditions providing stability of liposomal emulsion (the presence of antioxidants, stearic acid and cholesterol) were defined.
Griaznova
N S
NS
Petiushenko
R M
RM
Belianskaia
I V
IV
Saburova
L A
LA
Sazykin
Iu O
IuO
Navashin
S M
SM
D015250:Aclarubicin / Q000008:administration & dosage*; D002784:Cholesterol / Q000008:administration & dosage / Q000494:pharmacology; D017517:Commonwealth of Independent States; D004337:Drug Carriers; D004345:Drug Industry / Q000379:methods*; D004355:Drug Stability; D004655:Emulsions; D008081:Liposomes; D010713:Phosphatidylcholines / Q000008:administration & dosage / Q000494:pharmacology; D013229:Stearic Acids / Q000008:administration & dosage / Q000494:pharmacology; D013678:Technology, Pharmaceutical / Q000379:methods*; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology
D004337:Drug Carriers; D004655:Emulsions; D008081:Liposomes; D010713:Phosphatidylcholines; D013229:Stearic Acids; D014810:Vitamin E; D015250:Aclarubicin; D002784:Cholesterol
Vkliuchenie v liposomy protivoopukholevogo antibiotika aklarubitsina v zavisimosti ot usloviĭ inkapsulirovaniia.