title: A new, noninvasive method to monitor the aging of bioprosthetic valves in the mitral position.
abstract: Bioprosthetic valves undergo a tissue degeneration of unpredictable onset and amount. This process alters the structure and function of the valve and consequently shortens its lifespan. The echocardiographic technique usually used in the follow-up of these patients does not provide accurate information concerning the amount of prosthesis tissue degeneration. A new technique has been developed based on the spectral analysis of the first heart sound, which enables the evaluation of prosthetic leaflet stiffness. The Young's modulus (E) and stress (s) of the valve leaflets were derived as functions of the inner diameter of the heterograft and its primary vibration frequency, which can be obtained from the frequency spectrum of the first heart sound. Thirty-six patients with a mitral bioprosthetic valve were studied. Fifteen had thickening or calcification, or both, of the valvular leaflets at echocardiographic examination. In patients with a normal valve, E and s showed a good correlation with the duration of implantation (r = 0.909, p < 0.001; and r = 0.828, p < 0.001; respectively). Patients with abnormal leaflets had values of E and s that were greater than the theoretical values expected for their duration of implantation. The procedure is sensitive, accurate and easy to perform, and enables monitoring of the aging of the prosthetic valve and early identification of valve tissue degeneration. Together with echocardiography, this procedure yields a more complete evaluation of prosthetic valves for the follow-up of patients.
authors.affiliation: Cattedra di Fisiopatologia Applicata, Universita' di Sassari, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Longhini
authors.forename: E
authors.initials: E
authors.lastname: Baracca
authors.forename: C
authors.initials: C
authors.lastname: Brunazzi
authors.forename: V
authors.initials: V
authors.lastname: Gallucci
authors.forename: A
authors.initials: A
authors.lastname: Mazzucco
authors.forename: F
authors.initials: F
authors.lastname: Barbaresi
authors.forename: R
authors.initials: R
authors.lastname: Pansini
mesh_terms: D000368:Aged; D001705:Bioprosthesis; D005583:Fourier Analysis; D006350:Heart Valve Prosthesis / Q000295:instrumentation; D006801:Humans; D008875:Middle Aged; D008943:Mitral Valve; D010701:Phonocardiography; D011475:Prosthesis Failure; D012815:Signal Processing, Computer-Assisted