The effect of ascorbic acid on cadmium accumulation in guinea pig tissues.
Accumulation of cadmium in organs of guinea pigs after subchronic oral cadmium treatment (1 mg Cd/animal/24 h) was in the following order: kidneys > liver > heart > testes > brain. The preventive effects of high doses of ascorbic acid (AA) against cadmium deposition were more pronounced in the testes, heart and brain, and in the kidney only after short-term cadmium treatment. Ascorbic acid had no protective effect on cadmium accumulation in the liver.
Kadrabová
J
J
Institute of Preventive and Clinical Medicine, Bratislava, Czecho-Slovakia.
Madăric
A
A
Ginter
E
E
D000704:Analysis of Variance; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002104:Cadmium / Q000493:pharmacokinetics*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D012044:Regression Analysis; D013054:Spectrophotometry, Atomic; D013737:Testis / Q000187:drug effects / Q000378:metabolism; D014018:Tissue Distribution
D002104:Cadmium; D001205:Ascorbic Acid