title: Cefoxitin-induced antibiotic resistance in Enterobacter species in the community hospital.
abstract: The aim of this study was to determine whether beta-lactamases could be induced by cefoxitin in the community hospital, since this problem of antibiotic resistance has been shown to exist at the tertiary care level. One hundred sixty-six Enterobacter species isolated from patients in two community hospitals in Dayton, Ohio, were tested for cefoxitin induction of beta-lactamase production by a disk-approximation method. Piperacillin and cefoxitin disks were placed in approximation to each other on Mueller-Hinton plates inoculated with Enterobacter species with appropriate controls. Three Enterobacter strains (1.8%) showed truncation of the zone of inhibition (indicating beta-lactamase induction) with sensitivity to both cefoxitin and piperacillin. However, 84 strains (50.6%) showed truncation around the piperacillin disk with resistance to cefoxitin. One hundred fifty (90.0%) strains showed resistance to cefoxitin. These data indicate that cefoxitin induction of beta-lactamases in Enterobacter species is indeed a potential problem in incurring antibiotic resistance in the community hospital.
authors.affiliation: Department of Family Practice, Wright State University School of Medicine, Dayton, Ohio.
authors.forename: R I
authors.initials: RI
authors.lastname: Haddy
authors.forename: L A
authors.initials: LA
authors.lastname: Doughman
authors.forename: B L
authors.initials: BL
authors.lastname: Elder
authors.forename: R J
authors.initials: RJ
authors.lastname: Markert
mesh_terms: D002440:Cefoxitin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004754:Enterobacter / Q000187:drug effects*; D005194:Family Practice; D006764:Hospitals, Community; D006801:Humans; D008826:Microbial Sensitivity Tests; D001618:beta-Lactamases
chemical_list: D002440:Cefoxitin; D001618:beta-Lactamases