title: [Dose-dependent effect of diltiazem on some lipid metabolic parameters in hemorrhagic shock in cats].
abstract: The possibility of modulating the phospholipid composition in the plasma membranes of hepatocytes and adipocytes by the calcium channel blocker diltiazem was studied on a model of hemorrhagic shock. Diltiazem injection facilitated normalization of phosphatidylinositol metabolism in the hepatocyte plasma membranes. Injection of a high dose of diltiazem was attended by a rise of the phosphatidylethanolamine level. Only low doses of diltiazem caused a normalizing effect on the phospholipid composition of adipocyte plasma membranes. A low dose of diltiazem caused a reduction in the content of very low density lipoproteins in venous blood, while a high dose reduced the content of low density lipoproteins.
authors.forename: G F
authors.initials: GF
authors.lastname: Leskova
authors.forename: V I
authors.initials: VI
authors.lastname: Udobichenko
authors.forename: M V
authors.initials: MV
authors.lastname: Kalinina
mesh_terms: D000818:Animals; D002415:Cats; D004110:Diltiazem / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D010743:Phospholipids / Q000378:metabolism*; D012771:Shock, Hemorrhagic / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D010743:Phospholipids; D004110:Diltiazem
vernacular_title: Dozozavisimoe vliianie diltiazema na nekotorye pokazateli lipidnogo obmena pri gemorragicheskom shoke.