[Ca2+ channel blocking effect of panaxadiol saponins and panaxatriol saponins of cultured cardiac cells].
It was found that PDS and PTS decreased the action potential parameters of the cultured myocardiocytes in a dosage-dependent way. The effects of PDS 1000 micrograms/ml, PTS 200 micrograms/ml were in correspondence with the known Ca2+ channel blocker Mn2+ 0.05 micrograms/ml. Washing out, administration of epinephrine 10 micrograms/ml or Ca2+ 80 micrograms/ml were able to reverse the action potential from inhibition. The above results indicate that both PDS and PTS have Ca2+ channel blockade action.
Jiang
Y
Y
Norman Bethune University of Medical Sciences, Changchun.
Zhong
G
G
Shao
C
C
Yue
G
G
D000200:Action Potentials / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002478:Cells, Cultured; D036145:Ginsenosides; D009206:Myocardium / Q000166:cytology; D005894:Panax; D010946:Plants, Medicinal; D012503:Saponins / Q000494:pharmacology; D014315:Triterpenes / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D036145:Ginsenosides; D012503:Saponins; D014315:Triterpenes; C004564:panaxadiol; C004563:panaxatriol