Comparison of severity of viremia and antibody responses between infants and children with measles.
Severity of viremia and neutralizing antibody responses were compared between nine young infants (less than or equal to 10 months) with measles and 18 infants and children (greater than or equal to 11 months) with ordinary measles. Peripheral blood mononuclear cell (PBMC)-associated viremia was detected between the first day of elevation of fever (day 0) and day 5 of the disease in the former group, whereas PBMC-associated and cell-free viremia were detected between day 0 and day 14 in the latter group. The number of infected PBMC during the first 7 days of the disease was 3.22 +/- 1.07 (log10, mean +/- s.d.) per 10 million PBMC in the former group, which was significantly smaller (P = 0.02) than that of the latter group (4.21 +/- 1.18). The former group reached the maximum level of antibody earlier than the latter group.
Suga
S
S
Department of Pediatrics, Fujita Health University School of Medicine, Aichi, Japan.
Yoshikawa
T
T
Asano
Y
Y
Nakashima
T
T
Yazaki
T
T
D000367:Age Factors; D000914:Antibodies, Viral / Q000097:blood*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007963:Leukocytes, Mononuclear / Q000382:microbiology; D008297:Male; D008457:Measles / Q000276:immunology* / Q000382:microbiology; D008459:Measles virus / Q000302:isolation & purification; D009500:Neutralization Tests; D014766:Viremia
D000914:Antibodies, Viral