Exercise training has a heparin-like effect on lipoprotein lipase activity in muscle.
Lipoprotein lipase (LPL) is anchored with high affinity to heparan sulphate proteoglycans on the luminal surface of the capillary endothelium. The levels of pre-heparin perfusate LPL activity increased from 16 +/- 1 to 145 +/- 6 U/hindlimb (nine-fold increase) in hindlimb muscle of exercise-trained rats measured immediately after the last bout of work. At the same time, post-heparin perfusate LPL activity decreased from 63 +/- 2 to 13 +/- 1 U/hindlimb (p less than 0.001). These results provide evidence that exercise-training has a heparin-like effect on capillary-bound LPL. The total amount of LPL (i.e., pre-heparin perfusate plus post-heparin perfusate) was twofold greater in the hindlimb of the trained animals versus the controls. The effect of exercise on muscle LPL activity appears to last for as long as 5 days after cessation of exercise. Serum triglycerides were reduced 38% and plasma free fatty acids increased fourfold. These results provide evidence that training increases the capacity to remove triglycerides from circulation.
Oscai
L B
LB
Department of Physical Education, University of Illinois, Chicago 60680.
Tsika
R W
RW
Essig
D A
DA
D000273:Adipose Tissue / Q000166:cytology; D000818:Animals; D048429:Cell Size / Q000502:physiology; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006493:Heparin / Q000502:physiology*; D008071:Lipoprotein Lipase / Q000378:metabolism*; D008297:Male; D009132:Muscles / Q000201:enzymology*; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
D005230:Fatty Acids, Nonesterified; D014280:Triglycerides; D006493:Heparin; D008071:Lipoprotein Lipase