[Radiation protective properties of a synthetic antagonist of glucocorticoids RU 38486].
Radioprotective properties of synthetic antiglucocorticoid RU 38,486 were investigated. It was demonstrated that this antagonist of glucocorticoids possesses radioprotective effect in vitro and in vivo systems. Radioprotective properties at molecular level exhibited in inhibition of postirradiation endonuclease activation and in prevention of internucleosome chromatin degradation. Involvement of cytosol glucocorticoid receptors in initiation of radiation-induced programmed cell death is discussed.
Seĭliev
A A
AA
Zvonareva
N B
NB
Zhivotovskiĭ
B D
BD
Khanson
K P
KP
D000818:Animals; D016923:Cell Death; D002843:Chromatin / Q000187:drug effects / Q000528:radiation effects; D005938:Glucocorticoids / Q000037:antagonists & inhibitors*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D015735:Mifepristone / Q000494:pharmacology*; D011829:Radiation Dosage; D011837:Radiation-Protective Agents; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000502:physiology; D013601:T-Lymphocytes / Q000187:drug effects / Q000528:radiation effects
D002843:Chromatin; D005938:Glucocorticoids; D011837:Radiation-Protective Agents; D011965:Receptors, Glucocorticoid; D015735:Mifepristone
Issledovanie radiozashchitnogo deĭstviia sinteticheskogo antagonista gliukokortikoĭdov RU 38 486.