title: Differences between vasorelaxant responses of the canine and human mesenteric arteries and veins to amrinone.
abstract: Amrinone induced similar degrees of relaxation in human mesenteric arteries and veins contracted with KCl, but exerted a more potent vasodilator effect in canine mesenteric veins than in arteries. Dibutyryl cAMP had a stronger effect on KCl-induced contraction in canine mesenteric veins than in arteries. These results suggest that amrinone promotes a different vasodilating action in human and canine mesenteric vessels, possibly via different sensitivity to cAMP in each vascular smooth muscle.
authors.affiliation: Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Itoh
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: K
authors.initials: K
authors.lastname: Taniguchi
authors.forename: H
authors.initials: H
authors.lastname: Nakagawa
authors.forename: J
authors.initials: J
authors.lastname: Inui
authors.forename: J
authors.initials: J
authors.lastname: Takeuchi
mesh_terms: D000676:Amrinone / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects*; D008642:Mesenteric Veins / Q000187:drug effects*; D013045:Species Specificity; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D000676:Amrinone