Antibodies to lipid A in pauciarticular juvenile arthritis: clinical studies.
IgG antibodies to monophosphoryl lipid A (MPL) are more concentrated in synovial fluids than in the blood of children with pauciarticular juvenile arthritis. Correlations between IgG anti-MPL levels and numbers of inflamed joints were highly significant in 2 of 10 patients followed for 8 years and suggestive in 2 patients followed for shorter periods. A fifth patient had a correlation between IgM anti-MPL and joint count.
Miller
J J
JJ
Children's Hospital, Stanford University School of Medicine, CA.
Olds
L C
LC
D000293:Adolescent; D000906:Antibodies / Q000032:analysis* / Q000276:immunology; D001171:Arthritis, Juvenile / Q000097:blood / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008050:Lipid A / Q000276:immunology*; D013582:Synovial Fluid / Q000737:chemistry / Q000276:immunology; D013997:Time Factors
D000906:Antibodies; D008050:Lipid A