title: [Chromosome aberration induction in murine spermatocytes in joint exposure to radiation and sodium nitrite and nitrate].
abstract: In studying the combined effect of single and fractionated exposure to gamma/neutron radiation (12.5-50 cGy) and sodium nitrite (100 mg/kg) and chronic irradiation with a mixture of radiation (25 cGy) and sodium nitrite, nitrate (10-100 mg/l) the synergistic effect was observed in inducing reciprocal translocations in mouse spermatocytes. The dose-response function of the reciprocal translocations occurrence in Af mouse spermatocytes was nonlinear; there was a "plateau" within the dose range from 25 to 50 cGy.
authors.forename: S N
authors.initials: SN
authors.lastname: Sushko
authors.forename: A F
authors.initials: AF
authors.lastname: Malenchenko
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009566:Nitrates / Q000633:toxicity*; D012977:Sodium Nitrite / Q000633:toxicity*; D013090:Spermatocytes / Q000528:radiation effects* / Q000648:ultrastructure; D013997:Time Factors; D014178:Translocation, Genetic / Q000187:drug effects / Q000528:radiation effects
chemical_list: D009566:Nitrates; C031618:sodium nitrate; D012977:Sodium Nitrite
vernacular_title: Indutsirovanie khromosomnykh aberratsiĭ v spermatotsitakh mysheĭ pri sochetannom vozdeĭstvii radiatsii i nitrita, nitrata natriia.