Effect of preperfusion of lead and aminophylline on digoxin cardiotoxicity.
An attempt has been made to investigate the cardiotoxicity of an interaction of Lead acetate (LA), Aminophylline (APH) and Digoxin (DGN), employing an isolated frog heart preparation. While DGN-Cardiotoxicity was potentiated by LA-preperfusion, it was antagonized by APH-preperfusion as revealed by data reflecting the mean DGN perfusion time (Sec) and mean DGN exposure (microgram/10 mg heart weight) for cardiac arrest. In an experimental group involving interaction of LA, DGN and APH, preperfusion of APH has significantly diminished but not fully abolished LA-induced potentiation of DGN-cardiotoxicity. On the other hand, perfusion of APH after LA resulted not only in annulment of LA-induced potentiation but also in an eventual residual protective effect of APH. It was striking that simultaneous preperfusion of APH and LA led to exacerbation of LA-induced potentiation. The results of this interaction study involving two widely prescribed cardioactive drugs, are considered to be of immense pharmaco-toxicological interest.
Krishnamoorthy
M S
MS
Department of Pharmacology and Environmental Toxicology, Dr. ALM P.G. Institute of Basic Medical Sciences, University of Madras, Taramani, India.
Muthu
P
P
Kumaravel
T S
TS
D000628:Aminophylline / Q000633:toxicity*; D000818:Animals; D004077:Digoxin / Q000633:toxicity*; D004347:Drug Interactions; D004357:Drug Synergism; D006321:Heart / Q000187:drug effects*; D006331:Heart Diseases / Q000139:chemically induced*; D066298:In Vitro Techniques; D007854:Lead / Q000633:toxicity*; D010477:Perfusion; D011898:Ranidae; D013997:Time Factors
D000628:Aminophylline; D007854:Lead; D004077:Digoxin