Genetic variants of apolipoprotein B: relation to serum lipid levels and coronary artery disease among the Finns.
The genetic variation of apolipoprotein B has been studied extensively in Finns with the aid of protein and DNA polymorphisms. Population association studies confirmed significant associations between the XbaI polymorphism of the apolipoprotein B gene and elevated serum cholesterol levels, and dietary studies suggested that the XbaI and ins/del polymorphisms might modify the serum lipid response to dietary fat intake. Studies comparing patients and controls, however, did not confirm previous studies suggesting that the multi-allelic variation at the 3'VNTR region of the apolipoprotein B gene was associated with coronary artery disease. The results suggest that the apolipoprotein B gene is involved in the regulation of serum lipid levels. A yet unknown mutation in linkage disequilibrium with the XbaI site may contribute to this regulation.
Tikkanen
M J
MJ
First Department of Medicine, University of Helsinki, Finland.
Heliö
T
T
D000328:Adult; D000483:Alleles; D001055:Apolipoproteins B / Q000235:genetics*; D002648:Child; D003327:Coronary Disease / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D004247:DNA; D005387:Finland / Q000453:epidemiology; D005796:Genes / Q000235:genetics; D014644:Genetic Variation; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D011110:Polymorphism, Genetic; D012091:Repetitive Sequences, Nucleic Acid
D001055:Apolipoproteins B; D008055:Lipids; D004247:DNA