title: Interleukin-5.
abstract: Interleukin-5 is a dimeric cytokine that controls the differentiation of B cells into antibody-secreting cells as well as inducing the growth of Ly-1(CD5)+ B cells and B-cell tumors. It also has a major role of the growth and differentiation of eosinophils. Rapid progress has been made during the last year in the delineation of the structure and activities of interleukin-5, and the molecular nature of its functional receptors. Interleukin-5 exerts pleiotropic activities on various target cells through a high-affinity receptor which is composed of two different polypeptide chains, alpha and beta. The alpha chain binds interleukin-5 with low affinity and the beta chain has been identified as the interleukin-3 receptor-like protein and is also the beta chain of the granulocyte-macrophage colony stimulating factor receptor.
authors.affiliation: Department of Immunology, University of Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Takatsu
mesh_terms: D000818:Animals; D006801:Humans; D015848:Interleukin-5 / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / Q000737:chemistry; D011971:Receptors, Immunologic / Q000737:chemistry / Q000378:metabolism; D018123:Receptors, Interleukin; D016185:Receptors, Interleukin-3 / Q000737:chemistry; D053649:Receptors, Interleukin-5; D015398:Signal Transduction / Q000276:immunology
chemical_list: D015848:Interleukin-5; D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; D011971:Receptors, Immunologic; D018123:Receptors, Interleukin; D016185:Receptors, Interleukin-3; D053649:Receptors, Interleukin-5