title: A phase II study of 5-fluorouracil and high-dose folinic acid in combination with cyclophosphamide and mitoxantrone for advanced breast cancer.
abstract: 38 patients with advanced breast adenocarcinoma were treated in a phase II study with 5-fluorouracil and high-dose folinic acid combined with cyclophosphamide and mitoxantrone. 6 patients had received prior chemotherapy for advanced disease, all with an anthracycline-containing regimen. Treatment was generally well tolerated. The most common side-effect was myelosuppression, with 1 toxic death due to leukopenia-related sepsis. 1 patient developed severe congestive heart failure 12 months from the end of therapy. 36 patients were evaluable for response. The overall response rate was 55%. Median duration of response was 8 months and median survival time was 16 months. This regimen warrants further investigations.
authors.affiliation: Department of Medical Oncology, Ospedale Carlo Poma, Mantova, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Aitini
authors.forename: G
authors.initials: G
authors.lastname: Cavazzini
authors.forename: M
authors.initials: M
authors.lastname: Cantore
authors.forename: C
authors.initials: C
authors.lastname: Rabbi
authors.forename: A
authors.initials: A
authors.lastname: Rivera
authors.forename: B
authors.initials: B
authors.lastname: Togliani
authors.forename: A
authors.initials: A
authors.lastname: Di Marco
authors.forename: F
authors.initials: F
authors.lastname: Smerieri
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004341:Drug Evaluation; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006333:Heart Failure / Q000139:chemically induced; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D007970:Leukopenia / Q000139:chemically induced; D008875:Middle Aged; D008942:Mitoxantrone / Q000008:administration & dosage; D016879:Salvage Therapy; D013921:Thrombocytopenia / Q000139:chemically induced
chemical_list: D003520:Cyclophosphamide; D008942:Mitoxantrone; D002955:Leucovorin; D005472:Fluorouracil