The prognostic value of DNA content in patients with prostatic carcinoma.
In 80 patients with pathologically proven prostatic cancer, DNA content was correlated to grade, stage and survival. The survival curve and duration of response to therapy in these patients was examined. At the end of follow-up the cumulative survival curve in the aneuploid patients was 0.40, according to the Kaplan-Meier method, while in the diploid population it was 0.65. Differences between the two groups, aneuploid and diploid, were observed within the various histological subgroups: survival in the G2 population was 0.57 for the diploid and 0.30 for the aneuploid whereas in the G3 patients it was respectively 0.69 for the diploid and 0.05 for the aneuploid patients.
Di Silverio
F
F
Department of Urology, University of Rome La Sapienza, Italy.
D'Eramo
G
G
Caponera
M
M
Persechino
F
F
Eleuteri
P
P
Cavallo
D
D
De Vita
R
R
Forte
D
D
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004273:DNA, Neoplasm / Q000032:analysis*; D005434:Flow Cytometry; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008875:Middle Aged; D011003:Ploidies; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000235:genetics; D015996:Survival Rate
D004273:DNA, Neoplasm; D005819:Genetic Markers