The anticoagulants protein C and protein S display potent antiinflammatory and immunosuppressive effects relevant to transplant biology and therapy.
Hancock
W W
WW
Department of Pathology and Immunology, Monash Medical School, Melbourne, Victoria, Australia.
Tsuchida
A
A
Hau
H
H
Thomson
N M
NM
Salem
H H
HH
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002478:Cells, Cultured; D016027:Heart Transplantation / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007375:Interleukin-1 / Q000096:biosynthesis; D016030:Kidney Transplantation / Q000276:immunology / Q000502:physiology*; D009000:Monocytes / Q000187:drug effects / Q000276:immunology / Q000502:physiology*; D011486:Protein C / Q000494:pharmacology*; D017293:Protein S / Q000494:pharmacology*; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D014184:Transplantation, Homologous; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007166:Immunosuppressive Agents; D007375:Interleukin-1; D011486:Protein C; D017293:Protein S; D014409:Tumor Necrosis Factor-alpha