[New ampicillin derivatives with glyoxyloylbenzhydrazone side chains].
New ampicillin derivatives were synthesized from glyoxylic acid benzhydrazones by reaction with chloroformates via mixed anhydrides and ampicillin. These compounds were tested in an agar diffusion test against six different bacterial strains and also for their stability against beta-lactamases. Studies about structure-activity relationships have shown, that the activity against different bacterial strains is influenced in different manner by hydrophilic or hydrophobic and electronic properties of substituents.
Heinisch
L
L
Institut für Mikrobiologie und experimentelle Therapie (ZIMET), Jena.
Hanschke
K G
KG
Willitzer
H
H
Möllmann
U
U
Tresselt
D
D
Stengel
K
K
Eckardt
K
K
Kleinwächter
W
W
D000667:Ampicillin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects / Q000201:enzymology; D006038:Glyoxylates / Q000138:chemical synthesis* / Q000494:pharmacology; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D001618:beta-Lactamases / Q000378:metabolism
D006038:Glyoxylates; D006835:Hydrazones; D000667:Ampicillin; D001618:beta-Lactamases
Neue Ampicillinderivate mit Glyoxyloylbenzhydrazon-Seitenketten.