title: [Effects of alpha-interferon on the level of adenosine metabolism enzymes and bactericidal activity of macrophages in staphylococcal infection].
abstract: In staphylococcal infection the changes in functional ability of macrophages occur: their oxygen-depending bactericidity and adenosine-desaminase activity are depressed 5-nucleotidase ability increases. Introduction of homologous alpha-IFN in the dose of 1 x 10(3) u/mouse leads to enhancing macrophage bactericidity of the animals infected, inhibits their 5-nucleotidase activity and enhances adenosine desaminase one. Influence of alpha-IFN on the activity of adenosine metabolism enzymes in macrophages can be considered one of the most important mechanisms of its modulating effect in bacterial infections.
authors.forename: L N
authors.initials: LN
authors.lastname: Lazarenko
authors.forename: N Ia
authors.initials: NIa
authors.lastname: Spivak
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Umanskiĭ
authors.forename: N E
authors.initials: NE
authors.lastname: Vikhot'
authors.forename: V K
authors.initials: VK
authors.lastname: Ivanenko
mesh_terms: D015720:5'-Nucleotidase / Q000378:metabolism*; D000243:Adenosine Deaminase / Q000378:metabolism*; D000818:Animals; D001770:Blood Bactericidal Activity; D002478:Cells, Cultured; D016898:Interferon-alpha / Q000494:pharmacology*; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D008808:Mice, Inbred CBA; D013203:Staphylococcal Infections / Q000378:metabolism*; D013997:Time Factors
chemical_list: D016898:Interferon-alpha; D015720:5'-Nucleotidase; D000243:Adenosine Deaminase
vernacular_title: Vliianie alfa-interferona na uroven' fermentov obmena adenozina i bakteritsidnuiu aktivnost' makrofagov pri stafilokokkovoĭ infektsii.