title: Relation between monocytes in peripheral blood and development of atherosclerosis in hypercholesterolemic rabbits.
abstract: The relation among circulating monocytes, serum cholesterol and LDL cholesterol in manifestation of atherosclerosis was investigated in hypercholesterolemic rabbits. Serum cholesterol increased sharply and reached a plateau at 12 weeks after the start of cholesterol diet feeding; LDL cholesterol gradually increased until 24 weeks, and the number of monocytes in blood started to decrease abruptly around 12 weeks and resulted in less than 1% total white blood cells at 24 weeks, as reflected by a severe progression of atheroma formation. This result indicated that the decrement of monocyte number in blood was predictive of the presence of severe atherosclerotic plaques.
authors.affiliation: Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Inoue
authors.forename: Y
authors.initials: Y
authors.lastname: Nagatsu
authors.forename: K
authors.initials: K
authors.lastname: Wakabayashi
authors.forename: Y R
authors.initials: YR
authors.lastname: Seng
authors.forename: Y
authors.initials: Y
authors.lastname: Ogihara
mesh_terms: D000818:Animals; D001161:Arteriosclerosis / Q000097:blood*; D004032:Diet; D006937:Hypercholesterolemia / Q000097:blood*; D009000:Monocytes / Q000502:physiology*; D011817:Rabbits