Mechanism of the increase in lipid peroxide induced by cisplatin in the kidneys of rats.
To clarify the mechanism where by cisplatin induces increases in lipid peroxide, we examined the effects of antioxidants on changes in the activity of lipid peroxidation protecting enzymes in the kidneys of rats after cisplatin administration. alpha-Tocopherol and glutathione (GSH) significantly depressed lipid peroxidation in the kidneys of cisplatin-treated rats on the 4th day after cisplatin administration, and GSH depressed the increases in blood urea nitrogen levels induced by cisplatin. Thus, GSH appeared to reduce cisplatin-induced nephrotoxicity. However, alpha-tocopherol and GSH had no effect on the significant decrease in the activity of lipid peroxidation protecting enzymes induced in the kidney after cisplatin treatment. These results showed that lipid peroxide produced by cisplatin had no effect on these enzymes, suggesting that the increases of lipid peroxide were a result of the cisplatin-induced reduction in the activity of these enzymes.
Sadzuka
Y
Y
School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Shoji
T
T
Takino
Y
Y
D000818:Animals; D002374:Catalase / Q000378:metabolism; D002945:Cisplatin / Q000633:toxicity*; D004347:Drug Interactions; D005978:Glutathione / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology*
D008054:Lipid Peroxides; D014810:Vitamin E; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; D002945:Cisplatin