Inhibitors of calcium oxalate crystallization and urolithiasis.
In urolithogenic processes both, promoters and deficit of inhibitors, play an important role. The inhibitory action of added inhibitors (magnesium, citrate, pyrophosphate and chondroitin sulphate) was investigated using the urine of 72 patients with calcium urolithiasis. It was concluded that the deficit of inhibitors seems to be an important cause of stone formation in idiopathic oxalocalcic urolithiasis. Nevertheless, when that specific heterogeneous nucleation takes place it becomes an important factor and the inhibitor plays a complementary role in calcium oxalate urolithiasis.
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Department of Chemistry, Faculty of Sciences, University of the Balearic Islands, Spain.
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Costa-Bauzá
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D002129:Calcium Oxalate / Q000032:analysis / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D003460:Crystallization; D006801:Humans; D014545:Urinary Calculi / Q000737:chemistry* / Q000188:drug therapy / Q000378:metabolism
D002129:Calcium Oxalate