Quinolones as an alternative treatment of chlamydial, mycoplasma and gonococcal urogenital infections.
We report the results of several trials aimed at evaluating the quinolones in urogenital infections. In Chlamydia trachomatis infections, ofloxacin (200 mg b.i.d. for 10 days) gave a cure rate of 98% (n = 66), and fleroxacin (400 mg s.i.d. for 7 days) provided a cure rate of 89% (n = 19). A double-blind study comparing fleroxacin (600 mg s.i.d.) to doxycycline (100 mg b.i.d.) for 7 days showed similar high cure rates for both regimens (100%; n = 23). In Mycoplasma hominis infections, ofloxacin (200 mg b.i.d. for 10 days) yielded a cure rate of 86% (n = 50) for M. hominis and 55% (n = 43) for Ureaplasma urealyticum. Gonococcal infections (n = 122) were all cured by a single dose of 200 mg ofloxacin. Both ofloxacin and fleroxacin were well tolerated and may be recommended for patients with chlamydial or uncomplicated gonococcal infections, although 600 mg fleroxacin showed a higher incidence of adverse events compared to doxycycline.
Ziegler
C
C
Ludwig Boltzmann Institute for Research on Infectious Venerodermatological Diseases, Vienna, Austria.
Stary
A
A
Mailer
H
H
Kopp
W
W
Gebhart
W
W
Söltz-Szöts
J
J
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002690:Chlamydia Infections / Q000188:drug therapy*; D002692:Chlamydia trachomatis; D004311:Double-Blind Method; D005260:Female; D052776:Female Urogenital Diseases / Q000188:drug therapy* / Q000382:microbiology; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008297:Male; D052801:Male Urogenital Diseases; D009174:Mycoplasma; D009175:Mycoplasma Infections / Q000188:drug therapy*; D009344:Neisseria gonorrhoeae; D016869:Ureaplasma Infections / Q000188:drug therapy
D042462:4-Quinolones; D000890:Anti-Infective Agents