The proliferation theory of rejuvenation.
A theory concerning the molecular basis of rejuvenation is presented that postulates a central role for cell proliferation. This theory assumes that aging is due to the accumulation of multiple forms of molecular damage and that rejuvenation is due to repair. The advantages of proliferation as a means of repair are described and it is proposed that cell proliferation is required for full rejuvenation. This proliferation theory offers several advantages: a different perspective on the question of which organisms age; an explanation of aging-related phenomena that are not well handled by traditional aging theories; a novel approach to altering the aging rate; and testable implications for the design of new experimental systems and therapeutic interventions.
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Laboratory of Molecular Genetics, National Institute on Aging, Baltimore, MD 21224.
D000375:Aging / Q000473:pathology / Q000502:physiology; D000818:Animals; D002455:Cell Division / Q000502:physiology*; D016922:Cellular Senescence; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000473:pathology; D012060:Rejuvenation / Q000502:physiology*