Effects of intracerebroventricular administration of calcitonin gene-related peptide on passive avoidance behaviour in rats.
The effects of different doses of calcitonin gene-related peptide (CGRP) on passive avoidance behaviour were studied in male rats following its intracerebroventricular (i.c.v.) administration. Treatment with doses of 200 ng, 300 ng, 500 ng or 1 microgram was performed prior to learning, immediately and 6 h after the learning session and 30 min before the 24 h retention test. CGRP enhanced the avoidance latency in a dose-dependent manner at each time studied, with the exception of 6 h after the learning session. It is concluded that CGRP might be able to lengthen the passive avoidance latency by facilitating learning and memory formation.
Kovács
A
A
Department of Pathophysiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Telegdy
G
G
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D015740:Calcitonin Gene-Related Peptide / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats
D015740:Calcitonin Gene-Related Peptide