title: Isolation and sequence of a cDNA encoding the precursor of a bombesinlike peptide from brain and early embryos of Xenopus laevis.
abstract: A cDNA encoding the precursor of a bombesinlike peptide was isolated from brain of Xenopus laevis. The predicted end product resembles neuromedin B, which was originally isolated from mammalian spinal cord. The mRNA for this precursor was also present in gastrointestinal tract and in ovaries. Moreover, it could be detected in early embryos (stage 2 and stage 10) of X. laevis. These findings suggest novel roles for peptides of the bombesin family in oocyte maturation and early amphibian development.
authors.affiliation: Institute of Molecular Biology, Austrian Academy of Sciences, Salzburg.
authors.forename: C
authors.initials: C
authors.lastname: Wechselberger
authors.forename: G
authors.initials: G
authors.lastname: Kreil
authors.forename: K
authors.initials: K
authors.lastname: Richter
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001839:Bombesin / Q000235:genetics*; D001921:Brain / Q000502:physiology; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D015870:Gene Expression; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011498:Protein Precursors / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D016415:Sequence Alignment; D014982:Xenopus laevis / Q000196:embryology / Q000235:genetics*
chemical_list: D009419:Nerve Tissue Proteins; D011498:Protein Precursors; D012333:RNA, Messenger; D004247:DNA; D001839:Bombesin