Reversal of Na+ retention in chronic caval dogs by verapamil: contribution of medullary circulation.
The effects of verapamil on papillary plasma flow (PPF) and Na+ excretion were studied in anesthetized chronic caval dogs with low cardiac output and Na+ retention. Infusion of verapamil into the left renal artery (5 and 10 micrograms.kg-1.min-1) caused a dose-dependent ipsilateral increase in renal blood flow and Na+ excretion (from 10 +/- 2 to 171 +/- 32 and 225 +/- 35 mu eq/min, respectively). PPF in the left kidney was 26.6 +/- 4.4 and was significantly greater than that measured in the contralateral kidney (13.3 +/- 2.4 ml.min-1.100 g-1) (P < 0.01). The natriuresis occurred independent of changes in cardiac output and peripheral vascular resistance. In a separate group of caval dogs in which stimulation of the renin-angiotensin and adrenergic systems was intensified with a tighter caval constriction, verapamil failed to induce renal vasodilation or natriuresis and PPF was not altered. Despite the disparate hemodynamic responses, verapamil stimulated renal production of both renin and prostaglandin E2 in both groups of caval dogs. We conclude that the ability of verapamil to induce papillary vasodilation may contribute to the natriuresis seen in the caval dog, in which the site of Na+ retention includes the loop of Henle.
Chou
S Y
SY
Division of Nephrology and Hypertension, Brookdale Hospital Medical Center, Brooklyn, New York 11212.
Reiser
I
I
Porush
J G
JG
D000818:Animals; D002303:Cardiac Output, Low / Q000378:metabolism* / Q000503:physiopathology / Q000652:urine; D002908:Chronic Disease; D003251:Constriction, Pathologic; D015232:Dinoprostone / Q000097:blood; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D007679:Kidney Medulla / Q000098:blood supply*; D012079:Renal Circulation / Q000187:drug effects; D012083:Renin / Q000097:blood; D012964:Sodium / Q000378:metabolism*; D013909:Thorax; D014682:Vena Cava, Inferior; D014700:Verapamil / Q000494:pharmacology*
D012964:Sodium; D014700:Verapamil; D012083:Renin; D015232:Dinoprostone