Clinical application of peripheral nerve transplantation.
Surgical reconstruction of extensive peripheral nerve injuries frequently exhausts the patient's own source of expendable autogenous nerve grafts. Nerve allografts would offer a limitless supply of graft material. A 23-cm, 10-cable sciatic nerve allograft was performed in an 8-year-old boy in September of 1988. The patient was managed with Cyclosporin A for 2 years. Forty-four months after the transplant surgery and 19 months after the cessation of Cyclosporin A therapy, the patient has evidence of nerve regeneration across the allograft with recovery of functional sensibility in his foot. In the selected patient with an otherwise irreparable nerve injury, consideration can be given to the use of a nerve allograft.
Mackinnon
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Division of Plastic Surgery, Washington University and Barnes Hospital, St. Louis, Mo.
Hudson
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D002648:Child; D005121:Extremities / Q000294:innervation; D006801:Humans; D008297:Male; D009416:Nerve Regeneration; D010525:Peripheral Nerves / Q000637:transplantation*; D012584:Sciatic Nerve / Q000293:injuries* / Q000601:surgery; D014182:Transplantation, Autologous / Q000379:methods