title: Diffuse abdominal uptake of technetium-99m-methylene diphosphonate in a patient on continuous ambulatory dialysis during bone scintigraphy.
abstract: Extra-skeletal uptake of bone seeking radiopharmaceuticals has been documented by scintigraphy. We present a case of diffuse uptake of 99mTc-methylene diphosphonate (MDP) in the abdomen of a patient while undergoing continuous ambulatory peritoneal dialysis (CAPD) who had no symptoms or findings referable to the abdomen. We hypothesized that the 99mTc-MDP crossed the peritoneal membrane across a concentration gradient. An in-vitro simulation confirms that 99mTc-MDP will cross a semi-permeable membrane. Diffuse uptake of 99mTc-MDP may be a normal variant in patients on CAPD who have no signs or symptoms of peritonitis.
authors.affiliation: Brooke Army Medical Center, Fort Sam Houston, Texas.
authors.forename: G R
authors.initials: GR
authors.lastname: McDevitt
authors.forename: J D
authors.initials: JD
authors.lastname: Heironimus
authors.forename: M O
authors.initials: MO
authors.lastname: Toney
authors.forename: J L
authors.initials: JL
authors.lastname: Billingsley
mesh_terms: D000005:Abdomen / Q000000981:diagnostic imaging*; D000328:Adult; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D005260:Female; D005271:Femur Head Necrosis / Q000000981:diagnostic imaging; D006801:Humans; D007676:Kidney Failure, Chronic / Q000000981:diagnostic imaging / Q000628:therapy; D010531:Peritoneal Dialysis, Continuous Ambulatory; D011877:Radionuclide Imaging; D013669:Technetium Tc 99m Medronate
chemical_list: D013669:Technetium Tc 99m Medronate