[Changes in CSF resorption resistance. Experimental studies].
Lumbar infusion tests (IT) with different infusion rates (0.06 ml/min-1.2 ml/min) were used in order to investigate the intracranial pressure (ICP) and CSF outflow resistance (R) changes. Two groups of animals were studied: control group and animals with an 0.8 ml epidural balloon. In control group (without balloon) significant differences in ICP and R values between the increasing and decreasing IT curve were found. The most pronounced changes were noticed right after the highest infusion rate (40% for ICP value and 49% for R value). The results in the balloon group were very similar and the only difference were delayed ICP and R changes. The results obtained suggest that the determined R values are specific for the applied infusion rate and this phenomenon has to be taken into account in all human studies.
Jurkiewicz
J
J
Kliniki Neurochirurgii ICMDiK PAN, Warszawie.
Czernicki
Z
Z
Berdyga
J
J
Uchman
G
G
Matysiak
E
E
D000818:Animals; D002415:Cats; D002555:Cerebrospinal Fluid / Q000187:drug effects / Q000502:physiology*; D015170:Cerebrospinal Fluid Pressure / Q000187:drug effects / Q000502:physiology*; D004824:Epidural Space / Q000187:drug effects; D007263:Infusions, Parenteral / Q000379:methods; D008959:Models, Neurological; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology; D013115:Spinal Canal / Q000187:drug effects; D013997:Time Factors
D012965:Sodium Chloride
Zmienność oporu resorpcji. Badania doświadczalne.