[Lipids and serum apoproteins in subjects with slight or mild coronary atherosclerosis evaluated with angiography].
In this study 126 subjects (91 males and 35 females, range of age 43-65 years) were studied by coronary angiography. We considered positive for coronary atherosclerosis also patients showing mild or moderate stenosis (> or = 25%). In all subjects we have evaluated serum lipid and apoprotein A-I, B, C-II, C-III and E levels; therefore also cholesterol concentrations in all lipoprotein fractions, separated by sequential ultracentrifugation (VLDL d < 1.006, LDL d 1.006-1.063, HDL d > 1.063 g/ml) and apoprotein B in LDL have been measured. Subjects with coronary atherosclerosis have shown significantly higher levels of total cholesterol, LDL-cholesterol, total cholesterol/HDL-cholesterol and LDL-cholesterol/HDL-cholesterol ratios than controls. Therefore, a lower apo A-I/apo B ratio in males and a higher LDL-apo B levels in females has been found in subjects with coronary atherosclerosis in comparison with controls. The stepwise multiple analysis has demonstrated that LDL-cholesterol levels is the parameter that best correlates with the presence of coronary atherosclerosis. These data confirm the importance of the reduction of LDL-cholesterol levels in primary and secondary prevention of coronary heart disease.
Magnavacchi
P
P
Dipartimento di Cardiologia e Cardiochirurgia, Hesperia Hospital, Modena.
Boiardi
L
L
Barbagallo
M
M
Novo
S
S
Bertolotti
M
M
Benassi
A
A
Butturini
L
L
Biagi
R
R
Pedrazzini
F
F
Barbagallo
C M
CM
D001053:Apolipoproteins / Q000097:blood*; D002784:Cholesterol / Q000097:blood*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
D001053:Apolipoproteins; D002784:Cholesterol
Lipidi ed apoproteine sieriche in soggetti con aterosclerosi coronarica di grado lieve o moderata valutata angiograficamente.