[The cytotoxic action of metal stearates and its correlation with the toxicity for animals].
Toxic effects of lead, cadmium, barium, silver, zinc and calcium stearates on the Rh-type cells culture have been revealed. The expressiveness of the cytotoxic action correlated with the toxicity degree for laboratory animals. The strongest (r = 0,98; p less than 0,01) was the correlation between cytotoxicity parameter (the minimal cytoclastic concentration) and the inhalation toxicity parameter in animals (lim(ac)). The results permitted deriving formulae for predicting some toxicity parameters (intraperitoneal LD50, lim(ac)), hygienic regulations (MAC), and showed that the prediction based on cytotoxicity data is more reliable, than that based on toxicometric parameters in short-term experiments used for such purpose.
Deĭneka
S E
SE
Prodanchuk
N G
NG
Petrunik
I O
IO
Davydenko
I S
IS
Sinchenko
V G
VG
Shelifost
A V
AV
D000395:Air Pollutants, Occupational / Q000633:toxicity; D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007928:Lethal Dose 50; D008452:Maximum Allowable Concentration; D008670:Metals / Q000633:toxicity*; D051379:Mice; D051381:Rats; D013228:Stearates / Q000633:toxicity*
D000395:Air Pollutants, Occupational; D008670:Metals; D013228:Stearates
Tsitotoksicheskoe deĭstvie stearatov metallov i ego korreliatsiia s toksichnost'iu dlia zhivotnykh.