title: Acute hemodynamic effects of hypertonic (7.5%) saline infusion in patients with cardiogenic shock due to right ventricular infarction.
abstract: The hemodynamic effects, after infusion of 4 ml/kg of hypertonic (7.5%) saline solution (HS), were evaluated in six patients (mean age = 56.6 years) with cardiogenic shock (CS) due to right ventricular infarction (RVI). Basal condition data (mean +/- SEM) were as follows: cardiac index (CI) = 1.9 +/- 0.1 1/min/m2, arterial pressure (AP) = 66.5 +/- 0.9 mmHg, and systemic vascular resistance (SVR) = 31.3 +/- 1.0 mmHg/1/min/m2. Five- and 240-minute post-HS infusion data (respectively) revealed: CI = 3.3 +/- 0.1* and 2.9 +/- 0.1* 1/min/m2, AP = 87.7 +/- 1.6* and 80.7 +/- 2.2* mmHg, and SVR = 22.5 +/- 0.6* and 24.5 +/- 1.1* mmHg/1/min/m2 (*P less than 0.05 compared to baseline values). These data suggest that small-volume infusion of HS induced an important acute and sustained hemodynamic improvement in these patients with CS due to RVI.
authors.affiliation: Heart Institute, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Brazil.
authors.forename: J A
authors.initials: JA
authors.lastname: Ramires
authors.forename: C V
authors.initials: CV
authors.lastname: Serrano Júnior
authors.forename: L A
authors.initials: LA
authors.lastname: César
authors.forename: I T
authors.initials: IT
authors.lastname: Velasco
authors.forename: M
authors.initials: M
authors.lastname: Rocha e Silva Júnior
authors.forename: F
authors.initials: F
authors.lastname: Pileggi
mesh_terms: D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006982:Hypertonic Solutions / Q000494:pharmacology*; D009203:Myocardial Infarction / Q000150:complications; D012770:Shock, Cardiogenic / Q000188:drug therapy* / Q000209:etiology; D012965:Sodium Chloride / Q000494:pharmacology; D016278:Ventricular Function, Right
chemical_list: D006982:Hypertonic Solutions; D012965:Sodium Chloride