title: Blood compatibility of venous prosthesis made of textile or non-textile material.
abstract: To study blood compatibility of venous prosthesis made of textile or non-textile material, the inferior vena cava of 37 rabbits was partly replaced by 3 mm internal diameter synthetic tube graft made of textile material (T: woven tetron) or non-textile material (P: polytetrafluoroethylene). At designated time intervals after the replacement (5 hours to 4 weeks), graft patency was examined and the dry weight of intraluminal deposits was measured. The harvested grafts were then subjected to light and scanning electron microscopy. All the T-grafts were occluded as early as 5 hours after grafting but when ticlopidine was administered prior to the grafting, all the grafts were patent. All the P-grafts were patent up to 4 weeks after grafting, though the amount of intraluminal deposits was increased in a time related manner, narrowing the lumen of the grafts. The luminal surface of the P-grafts harvested at 5 hours after grafting was covered by piles of fibrin networks entrapping erythrocytes without an association of platelet aggregates, which resembles the finding in the T-grafts harvested from the ticlopidine treated rabbits. In the P-grafts, both the proximal and distal luminal surfaces near the anastomosis were fully covered with endothelial cells by 2 weeks and the entire luminal surface was covered with these cells by 4 weeks. From these results, the following conclusions were obtained; (1) P-graft was superior to T-graft for venous prosthesis, which is mainly due to the inertness of P against platelet activation. (2) Though the luminal surface of the P-grafts was completely covered with endothelial cells by 4 weeks after grafting, the lumen was markedly narrowed by intimal hyperplasia.
authors.affiliation: Department of Surgery II, Osaka University Medical School, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Kambayashi
authors.forename: M
authors.initials: M
authors.lastname: Watase
authors.forename: T
authors.initials: T
authors.lastname: Itoh
authors.forename: T
authors.initials: T
authors.lastname: Kawasaki
authors.forename: E
authors.initials: E
authors.lastname: Shiba
authors.forename: M
authors.initials: M
authors.lastname: Sakon
authors.forename: T
authors.initials: T
authors.lastname: Mori
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001807:Blood Vessel Prosthesis; D004730:Endothelium, Vascular / Q000648:ultrastructure; D004912:Erythrocytes; D005337:Fibrin; D006083:Graft Occlusion, Vascular / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control; D008297:Male; D008855:Microscopy, Electron, Scanning; D015539:Platelet Activation; D011093:Polyethylene Terephthalates; D011138:Polytetrafluoroethylene; D011817:Rabbits; D013924:Thrombophlebitis / Q000517:prevention & control; D013988:Ticlopidine / Q000008:administration & dosage / Q000627:therapeutic use; D014682:Vena Cava, Inferior / Q000601:surgery*
chemical_list: D001672:Biocompatible Materials; D011093:Polyethylene Terephthalates; D005337:Fibrin; D011138:Polytetrafluoroethylene; D013988:Ticlopidine