Left-handed first-episode, neuroleptic-naive schizophrenic patients have a higher prevalence of autoantibodies.
Using standard immunological techniques, sera from first-episode, neuroleptic-naive schizophrenic patients (n = 51) and age, race and sex matched healthy controls (n = 51) were screened for seven common autoantibodies. Significantly more left-handed (67%) than right-handed (23%) schizophrenic patients had autoantibodies (p = 0.011). Left-handed schizophrenic patients were six times more likely than right-handed patients or controls and four times more likely than left-handed controls to test positive for autoantibodies (p = 0.012). These data suggest that disease and sinistrality contribute to the excess of autoantibodies in schizophrenia.
Chengappa
K N
KN
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, School of Medicine, PA 15213-2593.
Ganguli
R
R
Yang
Z W
ZW
Brar
J S
JS
Li
L
L
Rabin
B S
BS
D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D001324:Autoantigens / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D016017:Odds Ratio; D011598:Psychoneuroimmunology; D012559:Schizophrenia / Q000175:diagnosis / Q000276:immunology*; D012565:Schizophrenic Psychology
D001323:Autoantibodies; D001324:Autoantigens