title: The relation between atherosclerosis and thrombosis.
abstract: BACKGROUND
  The relation between atherosclerosis and thrombosis has been recognized for over a century. Until very recently, however, this pathophysiological association has been largely based on observation with little information available to dissect molecular and cellular mechanism.
  
  
  RESULTS
  The known associations between the principal determinants of thrombosis (platelets, fibrin and its proteolytic degradation products, and fibrinolytic enzymes) and atherosclerosis; the regulation of thrombotic determinants by cytokines and growth factors important in atherogenesis; and the modulation of thrombotic determinants by atherogenic lipoproteins, especially lipoprotein(a), are discussed.
  
  
  CONCLUSIONS
  Within this conceptual framework, clear molecular and cellular mechanisms emerge, and a better basic understanding of the thrombotic determinants of atherogenesis can be developed.
authors.affiliation: Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115.
authors.forename: J
authors.initials: J
authors.lastname: Loscalzo
mesh_terms: D001161:Arteriosclerosis / Q000209:etiology* / Q000503:physiopathology; D001792:Blood Platelets / Q000502:physiology; D016207:Cytokines / Q000494:pharmacology; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D013917:Thrombin / Q000378:metabolism; D013927:Thrombosis / Q000150:complications* / Q000503:physiopathology; D010959:Tissue Plasminogen Activator / Q000378:metabolism; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism
chemical_list: D016207:Cytokines; D005338:Fibrin Fibrinogen Degradation Products; D013917:Thrombin; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator