Effects of aging and hypertension on plasma angiotensin II and platelet angiotensin II receptor density.
Plasma renin activity (PRA) declines with age in normal individuals, but the effect of age on plasma angiotensin II (ANG II) is less clear. A decline in plasma ANG II with age could result in altered platelet ANG II receptor density since plasma hormone levels influence their target organ receptors. To investigate this possibility, PRA, plasma ANG II, and platelet ANG II receptor density were examined in 17 young, 12 middle-aged, and 14 elderly healthy normotensive volunteers. To assess whether hypertension altered receptor density, these variables were also examined in 23 hypertensive patients. In normotensives, there was a negative correlation between age and PRA (r = -0.43, P < .05), no significant change in basal plasma ANG II with age, and a weak positive correlation between age and ANG II receptor density (r = 0.34, P < .05). Multiple regression analysis revealed that the relationship between age and ANG II receptor density was independent of the associated rise in mean arterial pressure with age (P < .05). Platelet ANG II receptor density was not significantly related to PRA or plasma ANG II. ANG II receptor affinity did not change with age. Neither PRA nor ANG II receptor density or affinity differed between hypertensives and normotensives of similar mean age, but plasma ANG II was significantly lower in hypertensives compared with normotensives. We concluded that aging is associated with a decline in supine PRA. The small decrease in plasma ANG II was not significant. Platelet ANG II receptor density increased with age primarily due to a small group of elderly subjects with elevated receptor density. There was no change in ANG II receptor density or affinity in hypertensives despite apparently lower plasma ANG II in these patients.
Duggan
J
J
Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, St. Stephens Green, Dublin.
Kilfeather
S
S
O'Brien
E
E
O'Malley
K
K
Nussberger
J
J
D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood*; D000804:Angiotensin II / Q000097:blood*; D001792:Blood Platelets / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008875:Middle Aged; D011945:Receptors, Angiotensin / Q000032:analysis*; D012016:Reference Values; D012044:Regression Analysis
D011945:Receptors, Angiotensin; D000804:Angiotensin II