Pharmacokinetics of nicotinamide and its effect on blood pressure, pulse and body temperature in normal human volunteers.
The pharmacokinetics of nicotinamide were studied in four human volunteers after oral doses of 1-6 g. Plasma concentrations and clearance rates of the vitamin were found to be dose-dependent, with a half-life of approximately 7-9 h for the two highest doses administered (4 and 6 g), approximately 4 h with 2 g and approximately 1.5 h with a 1-g dose. Peak concentrations ranged from 0.7 to 1.1 mumol.ml-1 after a 6-g dose. The time to reach peak plasma concentration was dose independent with a broad range from 0.73 to 3 h. In this study, nicotinamide had no detectable effect on blood pressure, pulse or body temperature.
Stratford
M R
MR
Cancer Research Campaign Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, UK.
Rojas
A
A
Hall
D W
DW
Dennis
M F
MF
Dische
S
S
Joiner
M C
MC
Hodgkiss
R J
RJ
D000284:Administration, Oral; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects*; D002245:Carbon Dioxide; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D009536:Niacinamide / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology*; D010100:Oxygen; D011674:Pulse / Q000187:drug effects*; D011838:Radiation-Sensitizing Agents
D011838:Radiation-Sensitizing Agents; D002245:Carbon Dioxide; D009536:Niacinamide; C011700:carbogen; D010100:Oxygen