title: Palpable abnormalities of the breast not requiring excisional biopsy.
abstract: The evaluation of a patient with a palpable abnormality of the breast typically includes physical examination, mammography and fine needle aspiration biopsy (FNAB) with cytologic interpretation of the aspirate. If the findings of these three diagnostic modalities are negative for malignancy, the current standard of care is to proceed to surgical biopsy to confirm the benign nature of the lesion. The current study was done to identify a subset of patients who could be safely observed without surgical (histologic) biopsy. These patients fulfilled specified criteria on physical examination, mammogram and needle sensation when the FNAB needle entered the lesion. Results of the cytologic studies of the FNAB were used as a corroborative rather than as a diagnostic test. Of 305 patients with mammary abnormalities, 106 were identified with "subsuspicious" lesions. Seven of the latter patients underwent surgical biopsy, four because the results of cytologic studies of FNAB revealed cytologic atypia. One of the four patients had infiltrating ductal carcinoma. All other patients have had follow-up evaluation for a mean of 61 months (range of 43 to 74 months). No carcinomas have developed at the subsuspicious site. The current study is the first to clearly define a subset of patients with palpable abnormalities of the breast who do not require surgical biopsy.
authors.affiliation: Department of Surgery, Albert Einstein Medical Center, Philadelphia, Pennsylvania 19141.
authors.forename: R G
authors.initials: RG
authors.lastname: Somers
authors.forename: G L
authors.initials: GL
authors.lastname: Sandler
authors.forename: M J
authors.initials: MJ
authors.lastname: Kaplan
authors.forename: D
authors.initials: D
authors.lastname: Najjar
authors.forename: A V
authors.initials: AV
authors.lastname: Anderson
authors.forename: M H
authors.initials: MH
authors.lastname: Cohen
mesh_terms: D000328:Adult; D001706:Biopsy; D001941:Breast Diseases / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008327:Mammography; D008875:Middle Aged; D010173:Palpation; D011446:Prospective Studies