title: [Incorporation of an antineoplastic drug aclarubicin into liposomes in relation to the conditions of its encapsulation].
abstract: The results of liposome drug encapsulation of aclarubicin (aclacinomycin A), an antitumor antibiotic, are presented. The method of flow detergent dialysis was applied. Conditions providing maximum encapsulation of aclarubicin (the ratio of lipid components and the lipid/detergent ratio), as well as conditions providing stability of liposomal emulsion (the presence of antioxidants, stearic acid and cholesterol) were defined.
authors.forename: N S
authors.initials: NS
authors.lastname: Griaznova
authors.forename: R M
authors.initials: RM
authors.lastname: Petiushenko
authors.forename: I V
authors.initials: IV
authors.lastname: Belianskaia
authors.forename: L A
authors.initials: LA
authors.lastname: Saburova
authors.forename: Iu O
authors.initials: IuO
authors.lastname: Sazykin
authors.forename: S M
authors.initials: SM
authors.lastname: Navashin
mesh_terms: D015250:Aclarubicin / Q000008:administration & dosage*; D002784:Cholesterol / Q000008:administration & dosage / Q000494:pharmacology; D017517:Commonwealth of Independent States; D004337:Drug Carriers; D004345:Drug Industry / Q000379:methods*; D004355:Drug Stability; D004655:Emulsions; D008081:Liposomes; D010713:Phosphatidylcholines / Q000008:administration & dosage / Q000494:pharmacology; D013229:Stearic Acids / Q000008:administration & dosage / Q000494:pharmacology; D013678:Technology, Pharmaceutical / Q000379:methods*; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D004337:Drug Carriers; D004655:Emulsions; D008081:Liposomes; D010713:Phosphatidylcholines; D013229:Stearic Acids; D014810:Vitamin E; D015250:Aclarubicin; D002784:Cholesterol
vernacular_title: Vkliuchenie v liposomy protivoopukholevogo antibiotika aklarubitsina v zavisimosti ot usloviĭ inkapsulirovaniia.