title: Serum gastrin is not higher in subjects with colonic neoplasia.
abstract: Two previous studies have shown higher circulating gastrin levels in subjects with colonic neoplasia than in colonoscopy-negative controls. In this much larger study, sera were collected from fasting subjects undergoing colonoscopy. Colonoscopy with biopsy classified participants as having colonic adenomas (N = 139), colon carcinoma (N = 29), or controls without colonic neoplasia (N = 150). Frozen, stored sera were later analyzed for gastrin by radioimmunoassay. Serum gastrin values were no higher in subjects with colonic adenomas or carcinoma than in colonoscopy-negative controls. We conclude that elevated serum gastrin levels play little, if any, role in the initiation of colonic neoplasia.
authors.affiliation: Department of Medicine, Walter Reed Army Medical Center, Washington, DC.
authors.forename: J W
authors.initials: JW
authors.lastname: Kikendall
authors.forename: A R
authors.initials: AR
authors.lastname: Glass
authors.forename: L H
authors.initials: LH
authors.lastname: Sobin
authors.forename: P E
authors.initials: PE
authors.lastname: Bowen
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D000236:Adenoma / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D016022:Case-Control Studies; D003110:Colonic Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D003113:Colonoscopy; D005260:Female; D005755:Gastrins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
chemical_list: D005755:Gastrins