Picrotoxin-induced tonic-clonic seizures and lethality are decreased by MK-801 in developing rats.
The action of MK-801 (NMDA antagonist; 0.1 and 0.5 mg/kg, IP) was tested against picrotoxin-induced seizures (3-6 mg/kg, IP) in rats aged 7, 12, 18, 25, and 90 days. We found MK-801 only inconsistently affected clonic seizures in 12- and 25-day-old rats, whereas tonic-clonic seizures were suppressed or delayed in almost all age groups. In addition, the lethality of picrotoxin was diminished by the higher dose of MK-801 in all age groups. The results suggest: a) different generators for both seizure patterns (clonic and tonic-clonic), b) an involvement of NMDA receptors in the genesis of tonic-clonic seizure pattern, and c) an interaction of MK-801 with GABAergic transmission throughout the entire development studied.
Velísková
J
J
Department of Physiology and Clinical Physiology, 3rd Faculty of Medicine, Charles University, Prague, Czechoslovakia.
Velísek
L S
LS
D000375:Aging / Q000502:physiology; D000818:Animals; D001259:Ataxia / Q000139:chemically induced / Q000503:physiopathology; D001522:Behavior, Animal / Q000187:drug effects; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced* / Q000517:prevention & control; D008297:Male; D010852:Picrotoxin / Q000037:antagonists & inhibitors / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar
D016291:Dizocilpine Maleate; D010852:Picrotoxin