Activation of T cells in vivo using anti-CD3 and staphylococcal enterotoxins.
One of the major problems in clinical immunity is that neoplastic and virally infected cells are insufficiently immunogenic to trigger an immune response. During the past several years, our laboratory has explored the use of T-cell-specific reagents including monoclonal antibodies (MAbs) and staphylococcal enterotoxins to amplify immune responses. This report summarizes our efforts to augment immunity with these agents.
Bluestone
J A
JA
Ben May Institute, University of Chicago, IL 60637.
Bruce
D S
DS
Newell
K A
KA
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D001427:Bacterial Toxins / Q000276:immunology*; D017252:CD3 Complex / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D008213:Lymphocyte Activation; D051379:Mice; D013210:Staphylococcus; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D001427:Bacterial Toxins; D017252:CD3 Complex