Amyloidoma of the CNS. I. Clinical and pathologic study.
We report a 32-year-old man with a 4-year history of headaches, seizures, and dementia secondary to multifocal amyloidomas in the white matter. Immunohistochemical and electron microscopic analyses suggest that the amyloidomas resulted from processing of plasma-cell-derived amyloidogenic protein by microglial cells.
Cohen
M
M
Division of Neuropathology, Case Western Reserve University, Cleveland, OH 44106.
Lanska
D
D
Roessmann
U
U
Karaman
B
B
Ganz
E
E
Whitehouse
P
P
Gambetti
P
P
D000328:Adult; D000686:Amyloidosis / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D001519:Behavior; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008854:Microscopy, Electron; D009420:Nervous System / Q000503:physiopathology