Cytological evaluation of the effect of Tamoxifen in premenopausal and post-menopausal women with primary breast cancer by analysis of the karyopyknotic indices of vaginal smears.
The influence of Tamoxifen on the vaginal epithelium of 33 premenopausal and 99 post-menopausal women with primary advanced breast cancer was investigated. The karyopyknotic index (KPI) values were assessed before starting therapy and at monthly intervals during therapy with Tamoxifen. A decrease in the KPI in menstruating women and a slight but definite increase in KPI values in post-menopausal women were observed.
Athanassiadou
P P
PP
Cytology and Cytogenetic Department, Alexandra Hospital, Medical School, University of Athens, Greece.
Kyrkou
K A
KA
Antoniades
L G
LG
Athanassiades
P H
PH
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology*; D002467:Cell Nucleus / Q000187:drug effects* / Q000473:pathology; D005260:Female; D006801:Humans; D008593:Menopause; D008598:Menstruation; D008875:Middle Aged; D013629:Tamoxifen / Q000494:pharmacology*; D014626:Vaginal Smears
D013629:Tamoxifen