[Autoradiography for drug metabolism and pharmacokinetics study].
Since Ullberg presented a macroautoradiograph showing the distribution of 35S-benzylpenicillin in rats by use of a commercial X-ray film in 1954, anything besides X-ray film has never been used for macroautoradiography. In the minireview a new type of radiation sensor, "Imaging Plate" (IP), is introduced as a useful sensor as a sensor that is more useful than previous ones. The IP is a photo-stimulable phosphor that can trap and store the radiation energy quantitatively. About 100 times higher sensitivity than any of ordinary X-ray films and very precise quantitativeness are demonstrated by many results reported recently. Simple procedures are herein presented with a few demonstrative examples of macro- and microautoradiography.
Shigematsu
A
A
Institute of Whole Body Metabolism, Chiba, Japan.
D000818:Animals; D001345:Autoradiography / Q000295:instrumentation / Q000379:methods*; D010400:Penicillin G / Q000378:metabolism / Q000493:pharmacokinetics; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010599:Pharmacokinetics; D014018:Tissue Distribution
D004364:Pharmaceutical Preparations; D010400:Penicillin G