title: Effect of platelet-poor plasma from patients with neurofibromatosis on the growth of cultured neurofibroma-derived fibroblast-like cells.
abstract: The effect of platelet-poor plasma from patients with von Recklinghausen's disease (neurofibromatosis, NF) on the cell growth of cultured neurofibroma-derived fibroblast-like cells (NF fibroblast-like cells grown from explant cultures of cutaneous neurofibromas) was examined. Platelet-poor plasma and sera from nine NF patients and nine control individuals were examined. When comparing platelet-poor plasma from patients with NF with control individuals, the former stimulated the proliferation of fibroblast-like cells derived from neurofibromas, not that of normal fibroblasts.
authors.affiliation: Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nogita
authors.forename: K
authors.initials: K
authors.lastname: Takehara
authors.forename: A
authors.initials: A
authors.lastname: Moro
authors.forename: F
authors.initials: F
authors.lastname: Otsuka
authors.forename: Y
authors.initials: Y
authors.lastname: Ishibashi
mesh_terms: D000328:Adult; D001792:Blood Platelets; D002455:Cell Division; D005260:Female; D005347:Fibroblasts / Q000473:pathology* / Q000502:physiology; D006801:Humans; D008297:Male; D009456:Neurofibromatosis 1 / Q000097:blood* / Q000503:physiopathology; D014407:Tumor Cells, Cultured