Endrin-induced production of nitric oxide by rat peritoneal macrophages.
The effect of oral endrin administration to rats on the production of nitric oxide (NO) by peritoneal macrophages was investigated. Nitric oxide formation was measured as nitrite. Endrin (4.5 mg/kg) enhanced the secretion of NO by approx. 300%. The effect of endrin on NO formation was both dose- and time-dependent. Ellagic acid, which has been shown to be a potent antioxidant, inhibited the elevation of NO production induced by endrin. These results suggest that the toxicity of endrin may at least in part be due to the production of an oxidative stress.
Akubue
P I
PI
School of Pharmacy and Allied Health, Creighton University, Omaha, NE 68178.
Stohs
S J
SJ
D000284:Administration, Oral; D000818:Animals; D004610:Ellagic Acid / Q000494:pharmacology; D004732:Endrin / Q000494:pharmacology*; D005260:Female; D008262:Macrophage Activation / Q000187:drug effects; D008264:Macrophages / Q000737:chemistry / Q000187:drug effects*; D009569:Nitric Oxide / Q000737:chemistry*; D009573:Nitrites / Q000032:analysis; D010537:Peritoneum / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D009573:Nitrites; D004610:Ellagic Acid; D009569:Nitric Oxide; D004732:Endrin