title: Surgical connections from ventricle to pulmonary artery. Comparison of four types of valved implants.
abstract: BACKGROUND
  Four types of valved conduits used to correct venous ventricle to pulmonary artery (V-PA) discontinuity were compared.
  
  
  RESULTS
  Four hundred fifty-seven patients with congenital heart defects requiring a V-PA connection during the past 25 years were reviewed. Age at implant varied from 1 day to 64 years (mean, 9.1 years). Four types of valved prostheses were used: 1) homograft conduit (HC, n = 178), 2) valved Dacron conduit (VDC, n = 126), 3) polystan conduit (PC, n = 47), and 4) orthotopic pulmonary valve implant (PVI, n = 106). There were 83 early deaths (18.2%) and 34 late deaths (8.5%). Follow-up ranged from 1 month to 22 years (mean, 3.5 years). One hundred eight conduit replacements were performed in 93 patients (21%). The overall patient survival was 73 +/- 2.3%, 67 +/- 3.2%, and 56 +/- 6.8% at 5, 10, and 15 years, respectively. Factors predictive of patient survival were diagnosis (p < 0.001) and valve size (p < 0.001). Age at operation (p < 0.001) and type of valve (p < 0.001) were the only risk factors for valve survival. At 5 years, survival of PVI (89 +/- 5%) and VDC (89 +/- 4%) was significantly better than survival of HC (46 +/- 13%) or PC (57 +/- 9%).
  
  
  CONCLUSIONS
  Patients who survived the initial construction of a V-PA conduit had a reasonable long-term survival. A PVI was the most durable prosthesis. A Dacron porcine-valved conduit had significantly better durability than either a cryopreserved homograft or a PC.
authors.affiliation: Division of Cardiovascular Surgery, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: A J
authors.initials: AJ
authors.lastname: Razzouk
authors.forename: W G
authors.initials: WG
authors.lastname: Williams
authors.forename: D C
authors.initials: DC
authors.lastname: Cleveland
authors.forename: J G
authors.initials: JG
authors.lastname: Coles
authors.forename: I M
authors.initials: IM
authors.lastname: Rebeyka
authors.forename: G A
authors.initials: GA
authors.lastname: Trusler
authors.forename: R M
authors.initials: RM
authors.lastname: Freedom
mesh_terms: D000206:Actuarial Analysis; D001021:Aortic Valve / Q000637:transplantation; D001705:Bioprosthesis; D002648:Child; D002675:Child, Preschool; D015925:Cryopreservation; D005260:Female; D005500:Follow-Up Studies; D006330:Heart Defects, Congenital / Q000401:mortality / Q000601:surgery*; D006350:Heart Valve Prosthesis / Q000401:mortality; D006801:Humans; D008297:Male; D011093:Polyethylene Terephthalates; D011651:Pulmonary Artery / Q000601:surgery*; D011664:Pulmonary Valve / Q000637:transplantation; D012307:Risk Factors
chemical_list: D011093:Polyethylene Terephthalates