title: Molecular definition of tumor antigens recognized by T lymphocytes.
abstract: Several tumor antigens recognized by T cells have now been identified at the molecular level. Various mechanisms can account for their expression: activation of normally silent genes; point mutations; chromosome translocations; and post-translational modifications of proteins. This led to the notion that potential tumor-rejection antigens can be shared by a significant proportion of human tumors. This may have important implications in cancer immunotherapy, especially since tumors expressing a defined antigen can be identified on the basis of the expression of the relevant gene.
authors.affiliation: Ludwig Institute for Cancer research, Brussels, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: van der Bruggen
authors.forename: B
authors.initials: B
authors.lastname: Van den Eynde
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis* / Q000235:genetics; D006801:Humans; D007167:Immunotherapy; D009369:Neoplasms / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000951:Antigens, Neoplasm