title: Use of magnetic resonance imaging to analyze the performance of hollow-fiber bioreactors.
abstract: Preliminary experiments were described that demonstrate that MRI is an effective tool for the noninvasive study of hollow-fiber bioreactors. Flow-compensated velocity-encoding pulse sequences were successively applied to analyze the velocity patterns in a module operated without cells, with an artificially induced flow field perturbation. Diffusion damping pulse sequences were also used to spatially resolve regions of cell growth in a bioreactor. These experiments provide the necessary basis from which future flow and spectroscopic studies can be conducted.
authors.affiliation: Department of Chemical Engineering, Worcester Polytechnic Institute, Massachusetts 01609.
authors.forename: C
authors.initials: C
authors.lastname: Donoghue
authors.forename: M
authors.initials: M
authors.lastname: Brideau
authors.forename: P
authors.initials: P
authors.lastname: Newcomer
authors.forename: B
authors.initials: B
authors.lastname: Pangrle
authors.forename: D
authors.initials: D
authors.lastname: DiBiasio
authors.forename: E
authors.initials: E
authors.lastname: Walsh
authors.forename: S
authors.initials: S
authors.lastname: Moore
mesh_terms: D000818:Animals; D001709:Biotechnology / Q000295:instrumentation / Q000379:methods; D002455:Cell Division; D002478:Cells, Cultured; D046508:Culture Techniques / Q000295:instrumentation* / Q000379:methods; D004058:Diffusion; D008279:Magnetic Resonance Imaging / Q000379:methods