Dissociation of neurocognitive deficits in a monozygotic twin pair concordant for schizophrenia.
Cognitive impairment varies markedly among schizophrenic individuals, although the reason for this is unknown. A monozygotic twin pair concordant for schizophrenia was evaluated using electrophysiological and neurobehavioral measures. Each twin showed a distinctive pattern of deficits; furthermore, clinical course and electrophysiological activity were not consonant with social and neurobehavioral functioning. Results suggest complex interrelationships between neurocognitive functioning and clinical presentation in schizophrenia.
Condray
R
R
Department of Veterans Affairs Medical Center, Pittsburgh, PA 15206.
Steinhauer
S R
SR
van Kammen
D P
DP
Zubin
J
J
D000328:Adult; D002540:Cerebral Cortex / Q000503:physiopathology; D004200:Diseases in Twins / Q000235:genetics* / Q000523:psychology; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology; D006801:Humans; D008297:Male; D019965:Neurocognitive Disorders / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology / Q000523:psychology; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D012565:Schizophrenic Psychology; D014430:Twins, Monozygotic / Q000235:genetics / Q000523:psychology; D014888:Wechsler Scales