[Effects of arginine on properties of the erythrocyte membrane in hypoxia].
The antioxidant effect of arginine evident from stabilization of membrane structure and properties and activation of oxygen-toxicity-protecting enzymes was demonstrated in hypoxia. The intraperitoneal injection of L-arginine-HCl in a dose of 120 mg per 100 g body mass prevented the increase of microviscosity, membrane permeability and lipid peroxidation products level in hypoxia. At the same time the activity of the antioxidant enzymes--superoxide dismutase and catalase--was increased in red blood cells by 64 and 46%, respectively.
Mogil'nitskaia
L V
LV
Fan
A n
An
Baranova
N Iu
NIu
Shugaleĭ
V S
VS
D000818:Animals; D001120:Arginine / Q000008:administration & dosage / Q000494:pharmacology*; D001809:Blood Viscosity; D002374:Catalase / Q000097:blood; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D000860:Hypoxia / Q000201:enzymology / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D015227:Lipid Peroxidation; D010539:Permeability; D051381:Rats; D013482:Superoxide Dismutase / Q000097:blood
D001120:Arginine; D002374:Catalase; D013482:Superoxide Dismutase
Vliianie arginina na svoĭstva éritrotsitarnykh membran v usloviiakh gipoksii.