title: The action of interleukin 6 on lymphoid populations.
abstract: We have analysed the role of IL-6 in activation of human lymphocytes isolated from peripheral blood. We found little effect of IL-6 on proliferation of T cells. IL-6 did stimulate production of IgM by B cells. However, it did not behave as a terminal differentiation factor and was required only during the first two days of the culture. Under most conventional stimulation conditions T cells themselves produce little or no IL-6. High IL-6 production could be induced by stimulating the cells with a combination of phorbol-12-myristate 13-acetate (PMA) and anti-CD28 antibodies.
authors.affiliation: Central Laboratory of the Netherlands Red Cross Bloodtransfusion Service, Amsterdam.
authors.forename: L A
authors.initials: LA
authors.lastname: Aarden
authors.forename: C
authors.initials: C
authors.lastname: van Kooten
mesh_terms: D001402:B-Lymphocytes / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis / Q000502:physiology*; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000378:metabolism
chemical_list: D015850:Interleukin-6