title: Viral susceptibility of an immortalized human microvascular endothelial cell line.
abstract: CDC/EU.HMEC-1 is the first immortalized human microvascular endothelial cell line that retains morphologic, phenotypic, and functional characteristics of a normal human microvascular endothelial cell. This study evaluates a variety of viruses and their effects on this human endothelial cell line. The data indicate that adenoviruses, some herpesviruses, reoviruses and most picornaviruses grow well in HMEC-1, with distinctive cytopathic effects. The paramyxoviruses, however, do not appear to propagate, nor does HIV. The findings indicate that microvascular endothelial cells may act as a reservoir of these viruses; it also suggests the possibility that microvascular endothelium could be involved in the processing and presentation of antigen to immune cells.
authors.affiliation: Biological Products Branch, Centers for Disease Control, Atlanta, Georgia 30333.
authors.forename: E W
authors.initials: EW
authors.lastname: Ades
authors.forename: J C
authors.initials: JC
authors.lastname: Hierholzer
authors.forename: V
authors.initials: V
authors.lastname: George
authors.forename: J
authors.initials: J
authors.lastname: Black
authors.forename: F
authors.initials: F
authors.lastname: Candal
mesh_terms: D000256:Adenoviridae / Q000254:growth & development / Q000472:pathogenicity; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral; D004730:Endothelium, Vascular / Q000166:cytology / Q000382:microbiology*; D006678:HIV / Q000254:growth & development / Q000472:pathogenicity; D006564:Herpesviridae / Q000254:growth & development / Q000472:pathogenicity; D006801:Humans; D010252:Paramyxoviridae / Q000254:growth & development / Q000472:pathogenicity; D010849:Picornaviridae / Q000254:growth & development / Q000472:pathogenicity; D012087:Reoviridae / Q000254:growth & development / Q000472:pathogenicity; D014773:Virology / Q000379:methods; D014780:Viruses / Q000254:growth & development / Q000472:pathogenicity*