title: Thermogenesis after surgery: effect of perioperative heat conservation and epidural anesthesia.
abstract: Body temperature, respiratory gas exchange, and plasma catecholamines were determined before and after surgery in three groups [control (C), warmed (W), and epidural (E) who received local anesthetic at T4-S5 dermatomes during and for 24 h after surgery] of patients undergoing colonic surgery under general anesthesia. At the end of surgery, group W were nursed in an ambient temperature of 28-30 degrees C, whereas the others were at 20-23 degrees C for a period of 24 h. Core (Tc) and dorsal hand temperature decreased during surgery in both C and E (P less than 0.05) but not in W. After surgery, Tc increased similarly in C and E and by a smaller amount in W. Plasma catecholamine concentrations increased significantly in C and W but not in E (P less than 0.001), with the greatest response occurring in C. Postoperative oxygen consumption and carbon dioxide production exceeded preoperative values (P less than 0.01) in C but not in W or E. After surgery, plasma albumin fell and C-reactive protein increased similarly in all three groups. Thus body heat conservation or epidural blockade attenuates or abolishes the rise in plasma catecholamines and oxygen consumption postoperatively but does not prevent the increase in Tc or the acute phase protein response.
authors.affiliation: Department of Anaesthesia, Northwick Park Hospital, Medical Research Council Clinical Research Centre, Harrow, Middlesex, United Kingdom.
authors.forename: F
authors.initials: F
authors.lastname: Carli
authors.forename: J
authors.initials: J
authors.lastname: Webster
authors.forename: P
authors.initials: P
authors.lastname: Nandi
authors.forename: I A
authors.initials: IA
authors.lastname: MacDonald
authors.forename: J
authors.initials: J
authors.lastname: Pearson
authors.forename: R
authors.initials: R
authors.lastname: Mehta
mesh_terms: D000767:Anesthesia, Epidural; D001831:Body Temperature; D001833:Body Temperature Regulation; D004837:Epinephrine / Q000097:blood; D006358:Hot Temperature; D006801:Humans; D007432:Intraoperative Period; D009638:Norepinephrine / Q000097:blood; D011184:Postoperative Period; D011659:Pulmonary Gas Exchange; D012768:Shivering; D013514:Surgical Procedures, Operative
chemical_list: D009638:Norepinephrine; D004837:Epinephrine