Interleukin-2.
In the past year there have been significant advances in understanding the role of interleukin-2. Its role in the activation of T cells by antigen-presenting cells, the structure-activity relationships between interleukin-2 and its receptor and the subsequent signaling have all become clearer. The creation of mice with a specific defect in the interleukin-2 gene has given us a clearer idea of its role in vivo. Recent studies also suggest that interleukin-2 may finally find a role in immunotherapy.
Smith
K A
KA
Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire 03755.
D000818:Animals; D015870:Gene Expression; D006801:Humans; D007165:Immunosuppression Therapy; D000922:Immunotoxins / Q000494:pharmacology; D007376:Interleukin-2 / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D015375:Receptors, Interleukin-2 / Q000737:chemistry; D015398:Signal Transduction / Q000276:immunology; D013329:Structure-Activity Relationship
D000922:Immunotoxins; D007376:Interleukin-2; D015375:Receptors, Interleukin-2