[Experimental study of anisodamine on therapeutic effect of pulmonary edema in rats].
The pulmonary edema (PE) induced by adrenaline (AD) is similar to neurogenic pulmonary edema. Anisodamine (654-2) showed an apparent therapeutic effect on it. The pulmonary wedge arterial pressure (PAWP), carotid arterial pressure (CAP) and blood gases were measured. It was found that in PE group, PAWP was increased to four-fold compared with those from before AD administration (from 0.98 +/- 0.24 to 4.04 +/- 0.53 kPa, mean +/- SD) rapidly. CAP was increased to one fold. The changes of PaO2,O2Sat and PaCO2 showed progressive hypoxia. The PaO2(kPa) was 11.0 +/- 1.3, 6.1 +/- 1.7, 4.4 +/- 1.9 and 3.8 +/- 1.9, PaCO2(kPa) was 4.1 +/- 2.1, 5.4 +/- 0.8, 9.7 +/- 2.9 and 10.3 +/- 3.4, O2 Sat(%) was 95.6 +/- 16.0, 69.2 +/- 15.1, 48.9 +/- 22.0, and 33.7 +/- 25.9 in order before AD injection, 1, 5 min after AD injection and before death respectively. Blood pH value also decreased in apparent way. All of animal died within 15 min. While in 654-2 therapeutic group, the significant increased PAWP and CAP were decreased gradually to normal within 30 min. The abnormal blood gases and pH were approached to repair within 20 min. All of animals survived.
Dai
S L
SL
Institute of Basic Medical Science, Chinese Academy of Medical Sciences, Beijing.
D000818:Animals; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000187:drug effects; D002339:Carotid Arteries / Q000503:physiopathology; D004837:Epinephrine; D008297:Male; D011654:Pulmonary Edema / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D011669:Pulmonary Wedge Pressure / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012991:Solanaceous Alkaloids / Q000494:pharmacology / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000494:pharmacology / Q000627:therapeutic use*
D012991:Solanaceous Alkaloids; D014665:Vasodilator Agents; C003922:anisodamine; D004837:Epinephrine