Synthesis of 6-substituted tetrazolo[1,5-c]pyrimidin-5(6H)ones: new modification of 3'-azido-3'-deoxythymidine.
An efficient method for the preparation of 6-methyltetrazolo-[1,5-c]pyrimidin-5(6H)ones using as the precursors 4-chloro-1,2-dihydro-1-methyl-2-oxopyrimidines is described. The method is also extended to the synthesis of novel tetrazole analogue of 3'-azido-3'-deoxythymidine (AZT).
Ciszewski
K
K
Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland.
Celewicz
L
L
Golankiewicz
K
K
D001393:Azoles / Q000737:chemistry; D011744:Pyrimidinones / Q000737:chemistry; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000138:chemical synthesis
D001393:Azoles; D011744:Pyrimidinones; D015215:Zidovudine