title: De novo biosynthesis and localization of immunoreactive inhibin (10.7 kDa) in normal human stomach.
abstract: We have previously reported the occurrence of inhibin-like peptide in gastric juice of normal men. In the present investigation, normal gastric mucosa was shown to synthesize inhibin, in vitro, as measured by 3H-leucine incorporation (Maximum at 18 h). Furthermore, the immunohistochemical localization studies demonstrated its presence in the acid secreting parietal cells and basal region of foveolar epithelium of gastric mucosa. Surprisingly, the protein secreting zymogen cells remained unstained.
authors.affiliation: Endocrinology Unit, Tata Memorial Centre, Parel, Bombay, India.
authors.forename: A A
authors.initials: AA
authors.lastname: Kapasi
authors.forename: P S
authors.initials: PS
authors.lastname: Mandrekar
authors.forename: A K
authors.initials: AK
authors.lastname: D'Cruz
authors.forename: J J
authors.initials: JJ
authors.lastname: Vyas
authors.forename: N A
authors.initials: NA
authors.lastname: Sheth
mesh_terms: D046508:Culture Techniques; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007265:Inhibins / Q000032:analysis / Q000096:biosynthesis*; D011233:Precipitin Tests
chemical_list: D007265:Inhibins