Quantification of beta A4 protein deposition in the medial temporal lobe: a comparison of Alzheimer's disease and senile dementia of the Lewy body type.
The distribution of beta-amyloid protein (beta A4) was examined in the medial temporal lobes from cases of Alzheimer's disease (AD) (n = 13), senile dementia of Lewy body type (SDLT) (n = 12) and age matched controls (n = 9). Using a previously described image analysis technique the extent of beta A4 pathology was determined in ten distinct anatomical sites within the medial temporal lobe. AD and SDLT cases contained very similar amounts of beta A4 in the areas sampled and both contained significantly more beta A4 than the age matched controls, particularly in the dentate and parahippocampal gyri. The similarity of the beta A4 load in the two conditions is in contrast to reported differences in the number of neurofibrillary tangles which can be observed. It is suggested that AD and SDLT represent a spectrum of pathology which centres around the aberrant processing of the beta A4 precursor protein.
Gentleman
S M
SM
Department of Anatomy, St. Mary's Hospital Medical School, Imperial College Institute of Science Technology and Medicine, London, UK.
Williams
B
B
Royston
M C
MC
Jagoe
R
R
Clinton
J
J
Perry
R H
RH
Ince
P G
PG
Allsop
D
D
Polak
J M
JM
Roberts
G W
GW
D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D003704:Dementia / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D016631:Lewy Bodies / Q000648:ultrastructure*; D008297:Male; D012016:Reference Values; D013702:Temporal Lobe / Q000378:metabolism*; D014018:Tissue Distribution
D016229:Amyloid beta-Peptides