Comparison of immunogenicity of hepatitis B vaccine between low and normal birth weight infants.
A comparative study was conducted to evaluate the immunogenicity of hepatitis B vaccine in low and normal birth weight infants. Hepatitis B vaccine (Hevac B Pasteur) was given to 50 low birth weight infants and 50 controls, matched by sex and date of delivery. The vaccine was given at birth, 1, 2 and 12 months of age. HBsAg and anti-HBs were assessed at birth, 4, 9 and 13 months of age by the micro-ELISA technique. Using the geometric mean titre of anti-HBs and the seroconversion rate as indicators, the immunogenicity of hepatitis B vaccine in low birth weight infants was as good as in normal birth weight infants.
Lumbiganon
P
P
Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Thailand.
Kowsuwan
P
P
Lumbiganon
P
P
Taksaphan
S
S
Panamonta
M
M
Assateerawatts
A
A
D006510:Hepatitis B Antibodies / Q000096:biosynthesis; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000009:adverse effects / Q000276:immunology*; D006801:Humans; D007230:Infant, Low Birth Weight / Q000276:immunology*; D007231:Infant, Newborn / Q000276:immunology*
D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines