title: [Digestive lymphomatous polyposis].
abstract: We report 7 prospectively followed cases of lymphomatous polyposis of the gastrointestinal tract. They were characterized by multiple polypoid lesions affecting several segments of the gastrointestinal tract always involving the colon and the rectum. An ileocecal mass was present in 4 cases. Regional lymph node involvement was constant. Peripheral lymphadenopathy was frequent (5 cases out of 7), as was other extra-digestive extension to the bone marrow (4 cases out of 7) and cavum (3 cases out of 7). The histopathological aspect was that of a small cleaved cells (working formulation) or centrocytic (Kiel classification) non-Hodgkin's lymphoma. The peculiar morphology and phenotype of the tumoral B-lymphocytes suggest their possible follicle marginal zone origin. Lymphomatous polyposis bore a rapidly fatal prognosis in every case (mean survival 20 months). This study of seven patients together with the 20 well-documented cases of the literature confirms the existence of lymphomatous polyposis as a distinctive clinicopathological entity among gastrointestinal non-Hodgkin's lymphoma.
authors.affiliation: Groupe d'Etude des Lymphomes Digestifs, Hôpital Saint-Lazare, Paris.
authors.forename: A
authors.initials: A
authors.lastname: Ruskoné-Fourmestraux
authors.forename: P
authors.initials: P
authors.lastname: Pescatore
authors.forename: J C
authors.initials: JC
authors.lastname: Rambaud
authors.forename: A
authors.initials: A
authors.lastname: Lavergne
authors.forename: J F
authors.initials: JF
authors.lastname: Colombel
authors.forename: C
authors.initials: C
authors.lastname: Eugène
authors.forename: R
authors.initials: R
authors.lastname: Modigliani
authors.forename: R
authors.initials: R
authors.lastname: Lemaire
authors.forename: J P
authors.initials: JP
authors.lastname: Gendre
authors.forename: A
authors.initials: A
authors.lastname: Galian
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000473:pathology*; D006801:Humans; D008207:Lymphatic Metastasis; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000188:drug therapy / Q000401:mortality / Q000473:pathology*; D011241:Prednisone / Q000627:therapeutic use; D011446:Prospective Studies; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D003520:Cyclophosphamide; D011241:Prednisone
vernacular_title: Polypose lymphomateuse digestive.