[Captopril-induced toxic hepatitis].
Captopril, the competitive inhibitor of angiotensin-converting enzyme, has proved efficient in the treatment of arterial hypertension and heart failure. Its use is generally associated with low incidence of adverse reactions and hepatic injury has not been emphasized as an important adverse reaction in Denmark. However worldwide, several cases of hepatic injury have been reported. We report one case of Captopril-induced hepatic injury. Despite discontinuation of Captopril a hepatorenal syndrome developed and the patient died five weeks after admission. This report emphasizes the need to be aware of the possibility of hepatic injury in patients receiving Captopril.
Pedersen
J H
JH
Hepatologisk afdeling A, Rigshospitalet, København.
Clementsen
P S
PS
Høyer
S
S
Hansen
B A
BA
D000368:Aged; D002216:Captopril / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D005260:Female; D006530:Hepatorenal Syndrome / Q000139:chemically induced; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology
D002216:Captopril
Captoprilinduceret toksisk hepatitis.