title: Role of adenosine in postprandial and reactive hyperemia in canine jejunum.
abstract: The role of adenosine in postprandial jejunal hyperemia was investigated by determining the effect of placement of predigested food into the jejunal lumen on blood flow and oxygen consumption before and during intra-arterial infusion of dipyridamole (1.5 microM arterial concn) or adenosine deaminase (9 U/ml arterial concn) in anesthetized dogs. Neither drug significantly altered resting jejunal blood flow and oxygen consumption. Before dipyridamole or deaminase, food placement increased blood flow by 30-36%, 26-42%, and 21-46%, and oxygen consumption by 13-22%, 21-22%, and 26-29%, during 0- to 3-, 4- to 7-, and 8- to 11-min placement periods, respectively. Adenosine deaminase abolished the entire 11-min hyperemia, whereas dipyridamole significantly enhanced the initial 7-min hyperemia (45-49%). Both drugs abolished the initial 7-min food-induced increase in oxygen consumption. Dipyridamole attenuated (14%), whereas deaminase did not alter (28%), the increased oxygen consumption that occurred at 8-11 min. Adenosine deaminase also prevented the food-induced increase in venoarterial adenosine concentration difference. In separate series of experiments, luminal placement of food significantly increased jejunal lymphatic adenosine concentration and release. Also, reactive hyperemia was accompanied by an increase in venous adenosine concentration and release. This study provides further evidence to support the thesis that adenosine plays a role in postprandial and reactive hyperemia in the canine jejunum.
authors.affiliation: Department of Physiology, Michigan State University, East Lansing 48824-1101.
authors.forename: D R
authors.initials: DR
authors.lastname: Sawmiller
authors.forename: C C
authors.initials: CC
authors.lastname: Chou
mesh_terms: D000241:Adenosine / Q000097:blood / Q000378:metabolism; D000243:Adenosine Deaminase / Q000494:pharmacology; D000818:Animals; D001157:Arterial Occlusive Diseases / Q000150:complications*; D001810:Blood Volume; D004176:Dipyridamole / Q000494:pharmacology; D004285:Dogs; D004435:Eating / Q000502:physiology*; D005260:Female; D006940:Hyperemia / Q000209:etiology*; D007583:Jejunum / Q000098:blood supply*; D008196:Lymph / Q000378:metabolism / Q000502:physiology; D008297:Male; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects
chemical_list: D004176:Dipyridamole; D000243:Adenosine Deaminase; D000241:Adenosine; D010100:Oxygen