title: Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells. 1978.
authors.forename: F W
authors.initials: FW
authors.lastname: Alt
authors.forename: R E
authors.initials: RE
authors.lastname: Kellems
authors.forename: J R
authors.initials: JR
authors.lastname: Bertino
authors.forename: R T
authors.initials: RT
authors.lastname: Schimke
mesh_terms: D000818:Animals; D004261:DNA Replication; D004351:Drug Resistance / Q000235:genetics; D049673:History, 20th Century; D008727:Methotrexate / Q000494:pharmacology*; D051379:Mice; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics*; D014407:Tumor Cells, Cultured / Q000201:enzymology
chemical_list: D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate