Radiation-induced micrencephaly in guinea pigs.
The effect of X rays on brain weight of guinea pig pups at birth was studied in 21-day-old embryos exposed in utero to doses of 75 and 100 mGy. When compared to controls and when corrected for body weight, gestation time, litter size, sex, and examiner differences, the brains of irradiated pups weighed approximately 46 mg less than those of controls (P < 0.001) for the 75-mGy group and about 55 mg less for the 100-mGy group. Brains of females weighed 51 mg less than those of males of the same body weight. Dam weight and caging conditions had no observed effect on brain weight.
Wagner
L K
LK
Department of Radiology, University of Texas Medical School, Houston 77030.
Johnston
D A
DA
Felleman
D J
DJ
D000818:Animals; D001921:Brain / Q000002:abnormalities* / Q000528:radiation effects; D005260:Female; D005333:Fetus / Q000528:radiation effects*; D006168:Guinea Pigs; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects