title: [Effect of doxycycline on leukocyte adhesion in a multifactorial experiment].
abstract: The multifactorial analysis was applied to study the effect of doxycycline on leukocyte adhesion to a plastic within wide ranges of the values of experimental factors such as doxycycline concentrations and magnesium and calcium ions. The data were computer-processed and second-order equations characterizing the influence of the factors on adhesion were derived. It was shown that the effect of the ions on adhesion was non-single-valued; accurate quantitative models describing the ion effect on adhesion were developed when the concentration of doxycycline was changed.
authors.forename: A V
authors.initials: AV
authors.lastname: Nikitin
authors.forename: A I
authors.initials: AI
authors.lastname: Zebrev
authors.forename: T V
authors.initials: TV
authors.lastname: Smolkina
mesh_terms: D000268:Adhesiveness / Q000187:drug effects; D000818:Animals; D002118:Calcium / Q000008:administration & dosage / Q000494:pharmacology; D015550:Cell Degranulation / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004318:Doxycycline / Q000008:administration & dosage / Q000494:pharmacology*; D006168:Guinea Pigs; D007124:Immunoenzyme Techniques / Q000295:instrumentation; D066298:In Vitro Techniques; D007962:Leukocytes / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D008274:Magnesium / Q000008:administration & dosage / Q000494:pharmacology; D008954:Models, Biological; D001619:beta-N-Acetylhexosaminidases / Q000097:blood
chemical_list: D001619:beta-N-Acetylhexosaminidases; D008274:Magnesium; D004318:Doxycycline; D002118:Calcium
vernacular_title: Izuchenie deĭstviia doksitsiklina na adgeziiu leĭkotsitov v mnogofaktornom éksperimente.