Autologous bacteria induce chemotaxis of peripheral blood mononuclear cells (MNC) from non-atopic asthmatics.
The chemotactic response of peripheral blood MNC from healthy subjects and non-atopic asthmatics against the respective pathogen isolated and cultured from sputum of individual patients was investigated. We found that the wide range of concentrations of autologous bacteria induced chemotaxis of MNC from asthmatics but showed no influence on MNC from healthy subjects. This finding might explain the mechanism of lymphocyte accumulation in the lungs of non-atopic asthmatics.
Zak-Nejmark
T
T
Department of Internal Medicine and Allergology, Medical Academy of Wrocław, Poland.
Małolepszy
J
J
Kraus-Filarska
M
M
Nadobna
G
G
Jutel
M
M
Stankiewicz
M
M
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000276:immunology* / Q000382:microbiology; D001419:Bacteria / Q000276:immunology* / Q000302:isolation & purification; D002634:Chemotaxis, Leukocyte; D005260:Female; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008297:Male; D008875:Middle Aged; D013183:Sputum / Q000382:microbiology*