[Effect of a drug isolated from the heart on the bioenergetics of cardiomyocytes in hypoxia and ischemia].
It has been established that cordialin inhibits selectively succinic acid oxidation and intensifies the exudation of a NADH2 substrate which is energetically more advantageous, and in this way has a favorable effect on energy metabolism, evidence of which is increase of the ATP content in the myocardium. Cordialin correction of the biologic energy of cardiomyocytes in hypoxia and ischemia prevents the accumulation of lipid drops in the cells of the peri-infarction zone, which reflects the high intensity of the processes of fatty acids beta-oxidation. As a result of this glycolysis activation is unnecessary (which is confirmed by high glycogen content, both of a qualitative and quantitative character, in the myocardium and low concentrations of glucose and lactate in the blood) and, consequently, the sequelae of acidosis are prevented.
Pavlenko
V S
VS
Khlystov
V V
VV
Andreeva
L I
LI
Ershov
V I
VI
Khavinson
V Kh
VKh
D000818:Animals; D002317:Cardiovascular Agents / Q000302:isolation & purification / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects*; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D000860:Hypoxia / Q000188:drug therapy*; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D017202:Myocardial Ischemia / Q000188:drug therapy*; D009206:Myocardium / Q000166:cytology; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats
D002317:Cardiovascular Agents; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C067671:cordialin
Vliianie preparata, vydelennogo iz serdtsa, na bioénergetiku kardiomiotsitov v usloviiakh gipoksii i ishemii.