Enhancement of the penetration of dithranol and increase of effect of dithranol on the skin by liposomes.
An assessment was made in healthy skin of dithranol erythema caused by a 10-min occlusive application of 0.5% dithranol (CAS 1143-38-0) in liposomal gel (Natipide II) with and without the addition of 3% salicylic acid, and of 0.5% dithranol in vaseline and in a removable standard ointment base, both with 3% salicylic acid. Both liposomal preparations led to a significant potentiation of the dithranol erythema. The results indicate a strong promotion of the penetration of dithranol by the liposomal gel.
Gehring
W
W
Hautklinik am Städtischen Klinikum Karlsruhe, Fed. Rep. of Germany.
Ghyczy
M
M
Gloor
M
M
Scheer
T
T
Röding
J
J
D000328:Adult; D000875:Anthralin / Q000493:pharmacokinetics* / Q000494:pharmacology*; D003124:Colorimetry; D004337:Drug Carriers; D004890:Erythema / Q000139:chemically induced; D005260:Female; D006801:Humans; D008081:Liposomes; D008297:Male; D010577:Petrolatum; D012869:Skin Absorption
D004337:Drug Carriers; D008081:Liposomes; D010577:Petrolatum; D000875:Anthralin