Neural retina-specific leucine zipper gene NRL (D14S46E) maps to human chromosome 14q11.1-q11.2.
The product of a neural retina-specific gene, NRL, belongs to the "leucine zipper" family of DNA-binding proteins and has a strong similarity to the v-maf oncogene product. The NRL gene maps to human chromosome 14 by Southern blot analysis of genomic DNA from a human-rodent somatic cell hybrid panel. In situ hybridization to metaphase chromosomes has further sublocalized the gene to the region 14q11.1-q11.2. D14S46E has now been assigned to the NRL gene. Because of its specific pattern of expression, NRL is a candidate gene for retinal diseases.
Yang-Feng
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TL
Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510.
Swaroop
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D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14; D006224:Cricetinae; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D016350:Leucine Zippers / Q000235:genetics*; D008677:Metaphase; D051379:Mice; D009474:Neurons / Q000378:metabolism; D012160:Retina / Q000378:metabolism*
D004268:DNA-Binding Proteins