title: Guided tissue regeneration using biodegradable membranes of polylactic acid or polyurethane.
abstract: The purpose of the present investigation was to evaluate the use of biodegradable membranes of polylactic acid or polyurethane for obtaining regeneration following treatment of circumferential periodontal defects in monkeys with the "guided tissue regeneration" procedure. Orthodontic elastic bands were placed around selected test and control teeth in 4 monkeys in order to induce breakdown of the periodontal tissues. When the destruction of the supporting tissues had progressed to a level corresponding to approximately half the length of the roots, the elastic bands were removed. After 1 to 8 months, full thickness flaps were raised on the buccal and lingual aspects of both test and control teeth. The exposed root surfaces were scaled and a notch was prepared in the root surface at the level of the reduced bone crest. Membranes of polylactic acid or polyurethane were placed circumferentially around the test teeth, while no membranes were placed around the control teeth. The tissue flaps were then sutured in a coronally displaced position. The surgical procedures and sacrifice of the animals were scheduled to provide observation times of 1, 4 and 8 months. During the healing period, various complications such as recession of the flap margins and exposure or exfoliation of the membranes were noticed. The histological analysis showed that the amount of new connective tissue attachment on test and control teeth did not differ and was restricted to the most apical part of the lesions. The bio-degradable membranes could be identified in a few specimens, and they were always surrounded by an epithelial layer.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Periodontology and Oral Gerontology, Royal Dental College, Arhus, Denmark.
authors.forename: K
authors.initials: K
authors.lastname: Warrer
authors.forename: T
authors.initials: T
authors.lastname: Karring
authors.forename: S
authors.initials: S
authors.lastname: Nyman
authors.forename: S
authors.initials: S
authors.lastname: Gogolewski
mesh_terms: D000818:Animals; D001673:Biodegradation, Environmental; D003094:Collagen; D003238:Connective Tissue / Q000473:pathology; D003739:Dental Cementum / Q000473:pathology; D004846:Epithelial Attachment / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D004867:Equipment Design; D005889:Gingival Recession / Q000209:etiology; D016557:Guided Tissue Regeneration, Periodontal; D007773:Lactates / Q000737:chemistry*; D019344:Lactic Acid; D008252:Macaca fascicularis; D008567:Membranes, Artificial; D010510:Periodontal Diseases / Q000473:pathology / Q000601:surgery*; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D011140:Polyurethanes / Q000737:chemistry*; D013499:Surface Properties; D013524:Surgical Flaps / Q000379:methods; D014092:Tooth Root / Q000473:pathology
chemical_list: D007773:Lactates; D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers; D011140:Polyurethanes; D019344:Lactic Acid; C033616:poly(lactide); D003094:Collagen