Effect of cobra venom factor on experimental infection of mice against Clostridium chauvoei.
The effect of cobra venom factor (CoVF) treatment was examined to clarify the mechanism of resistance of mice to Clostridium chauvoei infection. In CoVF-treated mice inoculated with spores of C. chauvoei, no death occurred and the organisms in the infected muscle progressively decreased, similar to that of non-treated control mice. These results indicated that C3 did not play a significant role in the resistance of mice against C. chauvoei infection.
Tamura
Y
Y
National Veterinary Assay Laboratory, Tokyo, Japan.
Kijima
M
M
Suzuki
S
S
Takahashi
T
T
Nakamura
M
M
D000818:Animals; D003015:Clostridium Infections / Q000276:immunology / Q000662:veterinary*; D003176:Complement C3 / Q000187:drug effects / Q000276:immunology*; D004546:Elapid Venoms / Q000494:pharmacology*; D005260:Female; D007113:Immunity, Innate / Q000187:drug effects; D051379:Mice / Q000276:immunology*
D003176:Complement C3; D004546:Elapid Venoms; C016310:cobra venom factor