Relative protection given by extract of Phyllanthus emblica fruit and an equivalent amount of vitamin C against a known clastogen--caesium chloride.
Aqueous extracts of Phyllanthus emblica L. fruit and an equivalent amount of vitamin C were administered orally by gavage to laboratory-bred Swiss albino mice for 7 days in order to evaluate the protection afforded by the two extracts against clastogenic effects of different doses of caesium chloride (CsCl) on bone marrow cells of Mus musculus in vivo. Both pretreatments significantly reduced the frequency of chromosome aberrations induced by CsCl given at three different doses, indicating that vitamin C, an essential component of P. emblica extract, was the effective agent in protecting against the clastogenicity of the metal salt.
Ghosh
A
A
Department of Botany, University of Calcutta, India.
Sharma
A
A
Talukder
G
G
D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D001853:Bone Marrow / Q000648:ultrastructure; D002586:Cesium / Q000633:toxicity*; D002712:Chlorides; D002869:Chromosome Aberrations; D051379:Mice; D009153:Mutagens / Q000633:toxicity*; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*
D002712:Chlorides; D009153:Mutagens; D010936:Plant Extracts; D002586:Cesium; C028019:cesium chloride; D001205:Ascorbic Acid