The role of the gastrointestinal microflora in postsurgical adhesion formation--a study in germfree rats.
The elucidation of the pathogenesis of postsurgical adhesion formation is still lacking. In this study experimental adhesion formation was studied in germfree (i.e. void of bacteria) and conventional rats (intestinal flora comprising over 400 species) using a caecal crush model. The germfree rats responded significantly weaker to the same stimuli, forming adhesions in only 20% of the cases as compared to the conventional rats 87.5% (p = 0.0076). The findings indicate that the bowel flora is of importance but not essential for postsurgical adhesion formation in rats.
Bothin
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Department of Surgery, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden.
Midtvedt
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T
D000005:Abdomen; D000818:Animals; D004064:Digestive System / Q000382:microbiology*; D005856:Germ-Free Life; D015994:Incidence; D011183:Postoperative Complications; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D000267:Tissue Adhesions / Q000453:epidemiology / Q000209:etiology*