title: Saccadic eye movements in Parkinson's disease: I. Delayed saccades.
abstract: The saccadic eye movements of nine patients with Parkinson's disease were compared to those of nine age-matched controls in two paradigms generating volitional saccades. In both paradigms, subjects had to make delayed saccades to peripheral LED targets: a peripheral target appeared 700 msec before a buzzer sounded, the buzzer being the signal to make a saccade to the target. In the first paradigm ("centre-off"), the fixation target was extinguished simultaneously with buzzer onset. In the second ("centre-remain") it was not extinguished until 1000 msec later. The results showed that for outward saccades in both paradigms, there was no difference between Parkinsonian patients and controls, but saccadic latencies were significantly shorter in the "centre-remain" paradigm. The initial outward saccades were indistinguishable from the normal, reflex saccades of the same subjects. However, saccades returning to the centre (a type of remembered target saccade) were hypometric and showed multistepping. Both effects were more pronounced in patients with Parkinson's disease. The significance of these findings in terms of current hypotheses about the nature of the Parkinsonian saccadic deficit is discussed.
authors.affiliation: Royal London Hospital, U.K.
authors.forename: C J
authors.initials: CJ
authors.lastname: Lueck
authors.forename: S
authors.initials: S
authors.lastname: Tanyeri
authors.forename: T J
authors.initials: TJ
authors.lastname: Crawford
authors.forename: L
authors.initials: L
authors.lastname: Henderson
authors.forename: C
authors.initials: C
authors.lastname: Kennard
mesh_terms: D000368:Aged; D001143:Arousal / Q000502:physiology; D001288:Attention / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D009802:Oculomotor Nerve / Q000503:physiopathology; D010300:Parkinson Disease / Q000503:physiopathology* / Q000523:psychology; D011930:Reaction Time / Q000502:physiology*; D012438:Saccades / Q000502:physiology*