Low-dose aspirin in primigravidae with positive roll-over test.
In a prospective, randomized, double-blind study for the prevention of pregnancy-induced hypertension and preeclampsia, 41 primigravidae with positive roll-over test (28th-32nd week of pregnancy) received 80 mg aspirin/day or placebo until the end of the 37th week. In the patients treated with acetylsalicylic acid (n = 22), 3 cases of proteinuria occurred, but no hypertensive pregnancy complication. In the placebo group (n = 19), 10 patients developed pregnancy-induced hypertension (6 of them preeclampsia). Group-specific differences concerning the occurrence of hypertension were statistically highly significant (p = 0.0004). No relevant differences were observed with regard to pregnancy duration, birth weight and umbilical artery pH value. The placebo group included 1 intrauterine death. No increased tendency to maternal or fetal bleeding was noticed.
Schröcksnadel
H
H
Department of Obstetrics and Gynecology, University of Innsbruck, Austria.
Sitte
B
B
Alge
A
A
Steckel-Berger
G
G
Schwegel
P
P
Pastner
E
E
Daxenbichler
G
G
Hansen
H
H
Dapunt
O
O
D001241:Aspirin / Q000008:administration & dosage* / Q000627:therapeutic use; D001794:Blood Pressure / Q000502:physiology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000517:prevention & control*; D007231:Infant, Newborn; D008297:Male; D010298:Parity; D011187:Posture; D011225:Pre-Eclampsia / Q000517:prevention & control*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis / Q000517:prevention & control*
D001241:Aspirin