[Effects of prolonged-action nitrates on platelet aggregation and prostaglandin formation].
Platelet aggregation and prostaglandin levels were examined in 50 patients with coronary heart disease concurrent with Functional Classes II-III angina who received nitroglycerin-retard (n = 20; Group 1), corovas (n = 20; Group 2), and placebo (n = 10; Group 3). Long-acting nitrates were found to exert a positive action on thrombocytic hemostasis as decreased platelet aggregation and reverse aggregation in 25% of the corovas-treated patients. Placebo failed to have the same action. Nitroglycerin-retard caused an increase in prostacyclin concentrations. Nitroglycerin-retard and corovas produced a clear-cut antianginal effect. They promoted the reduction in the number of anginal episodes and of nitroglycerin tablets used. No antianginal effect was absent when placebo was used.
Kirichenko
L L
LL
Masenko
V P
VP
Evdokimova
A G
AG
Iunusov
M A
MA
D000787:Angina Pectoris / Q000097:blood / Q000188:drug therapy; D003692:Delayed-Action Preparations; D006801:Humans; D008875:Middle Aged; D009566:Nitrates / Q000008:administration & dosage / Q000494:pharmacology*; D005996:Nitroglycerin / Q000008:administration & dosage / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D011453:Prostaglandins / Q000097:blood*
D003692:Delayed-Action Preparations; D009566:Nitrates; D010975:Platelet Aggregation Inhibitors; D011453:Prostaglandins; D005996:Nitroglycerin
Vliianie nitratov prolongirovannogo deĭstviia na agregatsiiu trombotsitov i produktsiiu prostaglandinov.