HB Al-Ain Abu Dhabi [alpha 18(A16)Gly----Asp]: a new hemoglobin variant discovered in an Emiratee family.
During a routine program of hemoglobin screening performed in the United Arab Emirates, we observed an electrophoretically fast-moving variant in a 9-month-old girl and in several members of her family. The structural determination, performed by reversed phase high performance liquid chromatography and amino acid sequencing, revealed a new variant that we named Hb Al-Ain Abu Dhabi [alpha 18(A16) Gly----Asp]. Its functional properties were normal.
Abbes
S
S
Department of Biology, Faculty of Sciences, United Arab Emirates University, Al-Ain.
M'Rad
A
A
Fitzgerald
P A
PA
Dormer
P
P
Blouquit
Y
Y
Kister
J
J
Galacteros
F
F
Wajcman
H
H
D000595:Amino Acid Sequence; D004586:Electrophoresis; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D006455:Hemoglobins, Abnormal / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D007223:Infant; D008403:Mass Screening; D014479:United Arab Emirates / Q000453:epidemiology
D006455:Hemoglobins, Abnormal; C077660:hemoglobin Al-Ain-Abu Dhabi