title: Hyperadrenocorticism in four cats.
abstract: This paper describes four cats with hyperadrenocorticism. Cat 1 showed polydipsia and polyphagia. Diabetes mellitus was initially diagnosed. As the animal appeared to be insulin resistant, pituitary and adrenocortical function tests were performed and the diagnosis of hyperadrenocorticism was made. Resistance to the high-dose dexamethasone suppression test was noticed in this cat. Pathological examination revealed a pituitary chromophobe adenoma. Cat 2 presented with diabetes mellitus, which was treated with insulin. The animal had a pendulous abdomen and its coat was in a poor condition. The low-dose dexamethasone suppression test demonstrated hyperadrenocorticism. Necropsy findings of pituitary tumour and hyperplasia of the adrenal cortex confirmed the diagnosis. Cat 3 showed clinical abnormalities indicative of hyperadrenocorticism, for instance, muscle weakness, alopecia, multiple abscesses. The diagnosis of hyperadrenocorticism was confirmed by the results of the lowe-dose dexamethasone suppression test. Pathological examination revealed an adrenocortical carcinoma. Cat 4 presented with polydipsia. The cause of this symptom was not found initially. One and a half years later additional symptoms, such as nephritis and polyphagia developed. Hyperadrenocorticism was diagnosed because of a palpable mass cranial to the left kidney. The diagnosis was confirmed by the results of the lowe-dose dexamethasone suppression test and the necropsy findings.
authors.affiliation: Department of Veterinary Pathology, State University Utrecht, The Netherlands.
authors.forename: W F
authors.initials: WF
authors.lastname: Immink
authors.forename: A J
authors.initials: AJ
authors.lastname: van Toor
authors.forename: J H
authors.initials: JH
authors.lastname: Vos
authors.forename: J S
authors.initials: JS
authors.lastname: van der Linde-Sipman
authors.forename: A A
authors.initials: AA
authors.lastname: Lubberink
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000175:diagnosis / Q000473:pathology; D002415:Cats; D003480:Cushing Syndrome / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D003907:Dexamethasone; D005260:Female; D006854:Hydrocortisone / Q000097:blood
chemical_list: D003907:Dexamethasone; D006854:Hydrocortisone