title: Slow and medium afterhyperpolarizations in maturing rat hippocampal CA1 neurones.
abstract: The postnatal evolution of the signals underlying the afterhyperpolarization (slow-AHP and medium-AHP) was studied in rat CA1 hippocampal neurones (P10-16, P17-23 and P greater than 26) using in vitro slices. Noradrenaline (NA) and signal subtraction were used to decompose the AHP (m-AHP and s-AHP). The amplitude of the s-AHP was found significant between P10-16 and P17-23 cells; the m-AHP showed no significant change. The time to peak of the s-AHP of the P greater than 26 cells was found to be significantly different from the remaining groups; the m-AHP showed no significant change. The changes in waveform and amplitude of the AHP at this stage were found to be mainly due to the modifications of the slow-AHP.
authors.affiliation: Departamento de Fisiologia, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Portugal.
authors.forename: P F
authors.initials: PF
authors.lastname: Costa
authors.forename: A I
authors.initials: AI
authors.lastname: Santos
authors.forename: M A
authors.initials: MA
authors.lastname: Ribeiro
mesh_terms: D000375:Aging / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D005576:Colforsin / Q000494:pharmacology; D005260:Female; D006624:Hippocampus / Q000187:drug effects / Q000254:growth & development / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology; D016716:PC12 Cells; D011712:Pyramidal Tracts / Q000187:drug effects / Q000254:growth & development / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005576:Colforsin; D002217:Carbachol; D009638:Norepinephrine