The activity and subcellular distribution of the peroxisomal enzyme acyl-CoA oxidase in human blood platelets.
The peroxisomal enzyme acyl-CoA oxidase is localized in the 'dense-tubular-system-enriched fraction', probably identical with the endoplasmic reticulum, in human blood platelets. This localization is strongly different from the localization of catalase which seems to be a cytosolic enzyme, in agreement with Marcus, Zucker-Franklin, Safir & Ullman [(1966) J. Clin. Invest. 45, 14-28]. A localization of acyl-CoA oxidase in the endoplasmic reticulum seems to be in good accordance with the important role of peroxisomes in the metabolism of prostaglandins, as recently demonstrated by Diczfalusy, Kase, Alexson & Bjørkhem [(1991) J. Clin. Invest. 88, 978-984].
Farstad
M
M
Laboratory of Clinical Biochemistry, University Hospital, University of Bergen, Norway.
Bakken
A M
AM
Berge
R K
RK
D042962:Acyl-CoA Oxidase; D006631:Amine Oxidase (Copper-Containing); D001792:Blood Platelets / Q000201:enzymology*; D002334:Carnitine O-Palmitoyltransferase / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D002478:Cells, Cultured; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008830:Microbodies / Q000201:enzymology*; D009245:NADH Dehydrogenase / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism*; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000378:metabolism
D010088:Oxidoreductases; D007770:L-Lactate Dehydrogenase; D002374:Catalase; D042962:Acyl-CoA Oxidase; D006631:Amine Oxidase (Copper-Containing); D000587:Oxidoreductases Acting on CH-NH Group Donors; D009245:NADH Dehydrogenase; D002334:Carnitine O-Palmitoyltransferase