Cell receptor-independent infection by a neurotropic murine coronavirus.
The cellular receptors for a coronavirus, mouse hepatitis virus (MHV), have been recently identified as one or more members of the carcinoembryonic antigen (CEA) family. The neurotropic JHM strain of MHV (MHV-JHM) possesses a highly fusogenic surface (S) glycoprotein. This protein is now shown to promote the spread of MHV into cells lacking the specific CEA-related MHV receptor. Resistant cells are recruited into MHV-induced syncytium with consequent production of progeny virus. Cell-to-cell spread of virus via membrane fusion without the requirement for specific cell surface receptor offers a novel way for virus to spread within infected hosts.
Gallagher
T M
TM
Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037.
Buchmeier
M J
MJ
Perlman
S
S
D000818:Animals; D002478:Cells, Cultured; D003332:Coronaviridae / Q000502:physiology*; D006224:Cricetinae; D015726:Giant Cells / Q000382:microbiology; D006801:Humans; D008562:Membrane Glycoproteins; D051379:Mice; D011817:Rabbits; D011991:Receptors, Virus / Q000378:metabolism; D064370:Spike Glycoprotein, Coronavirus; D014759:Viral Envelope Proteins / Q000378:metabolism; D014779:Virus Replication
D008562:Membrane Glycoproteins; D011991:Receptors, Virus; D064370:Spike Glycoprotein, Coronavirus; D014759:Viral Envelope Proteins