title: [Severely burned patients and atracurium: the train-of-four response].
abstract: Severely burned patients show a relative hyposensitivity to atracurium. The neuromuscular block obtained in 20 patients with major thermal injury after 0.75 mg.kg-1 i.v. of atracurium, by muscular activity recording (train of four-TOF), was studied. The results confirmed the resistance to atracurium, which mechanism is unknown. Even the doses administered, 50% higher than clinical dose (0.3-0.5 mg.kg-1), proved insufficient in order to obtain a complete neuromuscular block in severely burned patients.
authors.affiliation: Servizio di Anestesia e Rianimazione, USL 4, Parma, Italia.
authors.forename: C
authors.initials: C
authors.lastname: D'Eramo
authors.forename: L
authors.initials: L
authors.lastname: Lombardelli
authors.forename: S
authors.initials: S
authors.lastname: Lunardi
mesh_terms: D000328:Adult; D001279:Atracurium / Q000008:administration & dosage*; D002056:Burns / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000502:physiology*; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology
chemical_list: D001279:Atracurium
vernacular_title: Grands brûlés et atracurium: réponse au train de quatre.