Diseases associated with HTLV-I: virus, IL-2 receptor dysregulation and redox regulation.
HTLV-I, the etiological agent in adult T-cell leukemia, has also been strongly implicated in a number of non-neoplastic T-cell-associated diseases. Here, Junji Yodoi and Takashi Uchiyama review these associations and focus on the emerging concepts of IL-2R dysregulation and redox regulation by adult T-cell leukemia-derived factor in the pathogenesis of HTLV-I-related diseases.
Yodoi
J
J
Dept of Biological Responses, Kyoto University, Japan.
Uchiyama
T
T
D016356:Gene Products, tax / Q000276:immunology; D015481:HTLV-I Antibodies / Q000276:immunology; D015490:HTLV-I Infections / Q000235:genetics / Q000276:immunology*; D015368:Human T-lymphotropic virus 1 / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D010084:Oxidation-Reduction; D015375:Receptors, Interleukin-2 / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D016356:Gene Products, tax; D015481:HTLV-I Antibodies; D015375:Receptors, Interleukin-2