title: A novel endoscopic transgastric fundoplication procedure for gastroesophageal reflux: an initial animal evaluation.
abstract: Complications of gastroesophageal reflux are common in adults and children. A variety of surgical procedures have been successfully used to treat this condition. All current techniques require open surgery and are associated with significant morbidity and mortality, particularly in the high risk, neurologically damaged child. The authors have developed a novel method of creating a gastric fundoplication using an endoscopic transgastric approach in pigs. The procedure involves the creation of an esophageal intussusception into the stomach under direct vision with an endoscope. The gastric fundus is then plicated around the esophagus using a custom stapling device. The transgastric approach allows creation of a fundoplication, is easily performed, is potentially effective at preventing gastroesophageal reflux, and has the obvious advantages of minimally invasive surgery over open techniques of fundoplication.
authors.affiliation: Department of Surgery, University of California, San Francisco.
authors.forename: R W
authors.initials: RW
authors.lastname: Jennings
authors.forename: A W
authors.initials: AW
authors.lastname: Flake
authors.forename: G
authors.initials: G
authors.lastname: Mussan
authors.forename: M R
authors.initials: MR
authors.lastname: Harrison
authors.forename: N S
authors.initials: NS
authors.lastname: Adzick
authors.forename: C A
authors.initials: CA
authors.lastname: Pellegrini
mesh_terms: D000818:Animals; D005764:Gastroesophageal Reflux / Q000601:surgery*; D005773:Gastroscopy; D010535:Laparoscopy; D008722:Methods; D013270:Stomach / Q000601:surgery*; D013528:Surgical Staplers; D013552:Swine