title: Radiotherapy treatment planning of basal meningiomas: improved tumor localization by correlation of CT and MR imaging data.
abstract: A localization technique, based on three-dimensional CT and MR imaging data for precision radiotherapy of basal meningiomas, is presented. Indications for radiotherapy included unresected tumors, gross disease remaining despite surgery, and recurrences. The patient's head was fixed in a stereotactic localization system which is usable at the CT, MR and the linear accelerator installations. The geometrical distortion of MR imaging data was evaluated in three dimensions by phantom measurements. The geometrical distortion was "corrected" (reducing displacements to the size of a pixel) by calculations based on modelling the distortion as a fourth order two-dimensional polynomial. The target volume was defined in three-dimensional MR imaging data after application of 0.1 mmol/kg b.w. Gd-DTPA solution and transferred precisely from MR onto CT data to provide a map of the radiation attenuation coefficient for dose calculation. The superior soft tissue contrast of MR showed an excellent tumor delineation especially when the bony base of the skull obscured the target in CT images. Target volume, calculated dose distribution, and critical structures could be transferred between CT and MR imaging data and displayed as three-dimensional shaded structures for better assessment for matching of target volume and dose distribution. With the described planning system a more precise target definition of basal meningiomas was possible by integration of the superior tumor delineation in MR compared with CT.
authors.affiliation: Institute of Radiology and Pathophysiology, German Cancer Research Center, Heidelberg.
authors.forename: L R
authors.initials: LR
authors.lastname: Schad
authors.forename: G
authors.initials: G
authors.lastname: Gademann
authors.forename: M
authors.initials: M
authors.lastname: Knopp
authors.forename: H J
authors.initials: HJ
authors.lastname: Zabel
authors.forename: W
authors.initials: W
authors.lastname: Schlegel
authors.forename: W J
authors.initials: WJ
authors.lastname: Lorenz
mesh_terms: D003196:Computer Graphics; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000532:radiotherapy*; D008579:Meningioma / Q000175:diagnosis / Q000532:radiotherapy*; D011880:Radiotherapy Planning, Computer-Assisted; D011882:Radiotherapy, High-Energy / Q000295:instrumentation / Q000379:methods*; D014057:Tomography, X-Ray Computed