Protein dynamics and 1/f noise.
It has long been recognized that protein dynamical processes occur over a wide temporal range. However, the functionality of this spectrum of events remains unclear. In this work, a generalized noise function analysis is applied to a collection of diverse protein dynamical systems. It is shown that a power law model with an oscillatory component can adequately describe the time course of a variety of processes. These results suggest that under the appropriate conditions, proteins are in a metastable state. A microscopic, chemical kinetic model based on a Poisson distribution of activation energies is presented. From this model specific functional forms for the parameters of the generalized noise model can be derived. Additionally, a model is presented to described kinetic hole burning effects observed at low temperatures. Scaling laws are derived for these models that provide a connection with the generalized noise analysis.
Dewey
T G
TG
Department of Chemistry, University of Denver, Colorado 80208.
Bann
J G
JG
D001703:Biophysics / Q000379:methods; D007700:Kinetics; D008433:Mathematics; D009113:Muramidase / Q000737:chemistry; D009211:Myoglobin / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*; D012243:Rhodopsin / Q000737:chemistry; D013816:Thermodynamics
D009211:Myoglobin; D011506:Proteins; C018013:carboxymyoglobin; D012243:Rhodopsin; D009113:Muramidase