title: [Overdosage of glibenclamide presenting with lethargy and seizures in a child].
abstract: Management of accidental overdosage with oral hypoglycemic agents in toddlers may be difficult when the history of ingestion is overlooked. We report a 21-month-old girl who presented with lethargy and generalized seizures 12 hours after ingestion of an unknown number of glibenclamide pills. The blood glucose on admission was 0.5 mM/l. Symptoms resolved promptly after an intravenous bolus of glucose. Metabolic and infectious causes of hypoglycemia were ruled out. The parents denied drug ingestion initially, but further investigation revealed that she had ingested several glibenclamide pills used by her diabetic father 12 hours prior to admission. This case illustrates the problem involved in diagnosis and management of accidental drug overdosage in children when no such history is elicited and symptoms are delayed.
authors.affiliation: Pediatric Dept., Hadassah, University Hospital, Mt. Scopus, Jerusalem.
authors.forename: B
authors.initials: B
authors.lastname: Bar-Oz
authors.forename: Y
authors.initials: Y
authors.lastname: Amitai
mesh_terms: D062787:Drug Overdose; D005260:Female; D005905:Glyburide / Q000506:poisoning*; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced; D007223:Infant; D012640:Seizures / Q000209:etiology*; D012894:Sleep Stages; D013997:Time Factors
chemical_list: D005905:Glyburide