Comparison of sex steroid hormone-dependent induction of chick oviduct delta-aminolaevulinic acid dehydratase during primary and secondary stimulation.
1. A comparative study on primary and secondary stimulation of oviduct delta-aminolaevulinic acid dehydratase (ALAD) (EC 4.2.1.24) was carried out with oestradiol-17 beta and/or testosterone administration in immature female chickens during 15-day-primary stimulation, 20-day-withdrawal and 15-day-secondary stimulation periods. 2. Compared with primary stimulation in oestrogenized birds, synthesis and degradation rates of oviduct ALAD molecule during secondary stimulation increased 3.4- and 1.8-fold respectively, resulting in a rapid induction of the enzyme. 3. Specific activity of oviduct ALAD in oestradiol-plus-testosterone treated birds became significantly higher than that of oestradiol alone during secondary stimulation, whereas no significant changes were observed during primary stimulation.
Tsushima
N
N
Nippon Veterinary and Animal Science University, Tokyo, Japan.
Yamada
M
M
D000818:Animals; D002645:Chickens; D004790:Enzyme Induction / Q000187:drug effects; D004958:Estradiol / Q000008:administration & dosage; D005260:Female; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D006207:Half-Life; D007700:Kinetics; D009929:Organ Size / Q000187:drug effects; D010057:Oviducts / Q000033:anatomy & histology / Q000187:drug effects* / Q000201:enzymology*; D000623:Porphobilinogen Synthase / Q000096:biosynthesis*; D013739:Testosterone / Q000008:administration & dosage
D012739:Gonadal Steroid Hormones; D013739:Testosterone; D004958:Estradiol; D000623:Porphobilinogen Synthase