title: Pathophysiology of ovine trypanosomiasis: ferrokinetics and erythrocyte survival studies.
abstract: The haematological changes, erythrokinetics and ferrokinetics of sheep were investigated after infection with Trypanosoma congolense. Following the detection of parasites in blood, the infected sheep developed macrocytic hypochromic anaemia. Studies with 51Cr-red cells, 125I-albumin and 59Fe as ferric citrate 11 weeks after infection revealed that infected sheep had significantly lower mean circulating red cell volumes but higher plasma and blood volumes than control sheep. The infected sheep also had enhanced erythropoietic activity as judged by significantly higher plasma iron turnover rates, faster disappearance of radio-labelled iron and higher iron incorporation rates than control sheep. The rate of disappearance of 51Cr-labelled red cells was greater in infected than in control sheep. It was concluded that the anaemia observed at this stage of infection was due to an increased rate of removal of red cells from the circulation coupled with haemodilution, with no evidence of dyshaemopoiesis.
authors.affiliation: University of Glasgow Veterinary School.
authors.forename: E
authors.initials: E
authors.lastname: Katunguka-Rwakishaya
authors.forename: M
authors.initials: M
authors.lastname: Murray
authors.forename: P H
authors.initials: PH
authors.lastname: Holmes
mesh_terms: D000740:Anemia / Q000469:parasitology / Q000662:veterinary*; D000818:Animals; D004905:Erythrocyte Aging; D007501:Iron / Q000097:blood*; D007700:Kinetics; D008297:Male; D012756:Sheep; D012757:Sheep Diseases / Q000097:blood* / Q000469:parasitology; D014348:Trypanosoma congolense; D014353:Trypanosomiasis, African / Q000097:blood / Q000662:veterinary*
chemical_list: D007501:Iron