title: Principles and criteria in the development and optimization of topical therapeutic products.
authors.affiliation: Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD 20875.
authors.forename: V P
authors.initials: VP
authors.lastname: Shah
authors.forename: C R
authors.initials: CR
authors.lastname: Behl
authors.forename: G L
authors.initials: GL
authors.lastname: Flynn
authors.forename: W I
authors.initials: WI
authors.lastname: Higuchi
authors.forename: H
authors.initials: H
authors.lastname: Schaefer
mesh_terms: D000287:Administration, Topical; D000818:Animals; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D006801:Humans; D008954:Models, Biological; D010599:Pharmacokinetics; D012867:Skin / Q000378:metabolism; D013810:Therapeutic Equivalency