[Four-stranded complexes of oligonucleotides--quadruplexes].
The review presents analysis of the experimental, model and calculation studies concerned with the formation of the four-stranded helices of the natural and synthetic oligonucleotides. Guanine-rich oligonucleotides form stable four-stranded helices. Structures of such complexes were investigated by means of X-rays and spectrographic methods. These works have been reviewed in the first part. There are three possible variants of noncanonical structures formed by oligoguanylic acids. Two of them--four-stranded helices differed by the mutual direction of the sugar-phosphate chains. The third one is the two-stranded hairpin. Regulation of the number of cellular processes by means of the structural conversions between these three forms of guanine-rich motifs are investigated in articles reviewed in the second part. These works are concerned with the structural organization and functions of telomers, and on the other hand with the possible role of quadruplexes in self-recognition processes of the four homologous chromatids during meiosis and the following recombination. The third part of the review considers quadruplexes with an arbitrary sequence. In general there are model works inspired by investigations of recombination and replication processes. Experimental data concerned with the formation of quadruplex structures from two decamer Watson-Crick base paired duplexes oligo(dA).oligo(dT) are also presented.
Il'icheva
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Florent'ev
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D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry*; D016615:Telomere; D014961:X-Ray Diffraction
D009841:Oligonucleotides
Chetyrekhtsepochechnye kompleksy oligonukleotidov--kvadrupleky.