Electron impact and fast atom bombardment mass spectrometric analysis of the food-borne carcinogens 2-amino-3-methylimidazo [4,5-f] quinoline, 2-amino-3,8-dimethylimidazo [4,5-f] quinoxaline and their metabolites.
Electron impact (EI) and fast atom bombardment (FAB) mass spectrometry were used to characterize the heterocyclic aromatic amines, 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline and their metabolites. The carcinogenic N2-hydroxy metabolites and several non-conjugated detoxification products were analysed directly by EI mass spectrometry, while several polar sulphate and beta-glucuronic acid conjugates were analysed by FAB mass spectrometry. Analysis of beta-glucuronic acid conjugates was also achieved by EI mass spectrometry following silylation.
Fay
L B
LB
Nestec Ltd, Nestlé Research Centre, Lausanne, Switzerland.
Turesky
R J
RJ
D002273:Carcinogens / Q000032:analysis*; D005504:Food Analysis; D005965:Glucuronates / Q000032:analysis; D011804:Quinolines / Q000032:analysis*; D011810:Quinoxalines / Q000032:analysis*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013431:Sulfates / Q000032:analysis
D002273:Carcinogens; D005965:Glucuronates; D011804:Quinolines; D011810:Quinoxalines; D013431:Sulfates; C029216:2-amino-3-methylimidazo(4,5-f)quinoline; C036990:2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline