Suramin changes the fate of Spemann's organizer and prevents neural induction in Xenopus laevis.
Suramin, a polyanionic compound, which has previously shown to dissociate platelet derived growth factor (PDGF) from its receptor, prevents the differentiation of neural (brain) structures of recombinants of dorsal blastopore lip (Spemann's organizer) and competent neuroectoderm. Furthermore, the suramin treatment changes the prospective differentiation pattern of isolated blastopore lip. While untreated dorsal blastopore lip will differentiate into dorsal mesodermal structures (notochord and somites), suramin treated dorsal blastopore lip will form ventral mesoderm structures, especially heart structures. The results are discussed in the context of the current opinion about the mode of action of different growth factor superfamilies.
Grunz
H
H
Universität GHS Essen, Abt. für Zoophysiologie, Germany.
D000818:Animals; D004627:Embryonic Induction / Q000187:drug effects*; D005775:Gastrula / Q000187:drug effects*; D006133:Growth Substances / Q000502:physiology; D006321:Heart / Q000187:drug effects / Q000196:embryology; D008648:Mesoderm / Q000187:drug effects*; D009672:Notochord / Q000187:drug effects* / Q000196:embryology; D010982:Platelet-Derived Growth Factor / Q000037:antagonists & inhibitors; D017479:Receptors, Platelet-Derived Growth Factor / Q000187:drug effects; D013498:Suramin / Q000494:pharmacology*; D014982:Xenopus laevis / Q000196:embryology*
D006133:Growth Substances; D010982:Platelet-Derived Growth Factor; D013498:Suramin; D017479:Receptors, Platelet-Derived Growth Factor