title: Mutagenicity and antimutagenicity of hispidulin and hortensin, the flavonoids from Millingtonia hortensis L.
abstract: Studies of the mutagenicity and antimutagenicity of hispidulin and hortensin, the flavonoids from Millingtonia hortensis L. (Bignoniaceae), were performed using the liquid preincubation method of the Salmonella/microsome test. At the highest dose tested, 100 micrograms/plate, both compounds showed no mutagenicity and no cytotoxicity toward S. typhimurium strains TA98 and TA100 either in the presence or absence of S9 mix. However, these substances were antimutagens toward 2-aminoanthracene, aflatoxin B1 (in TA98), and dimethylnitrosamine (in TA100); but neither substance inhibited the direct mutagenic activity of 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide nor that of sodium azide in strains TA98 and TA100, respectively.
authors.affiliation: Department of Microbiology, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
authors.forename: M
authors.initials: M
authors.lastname: Chulasiri
authors.forename: N
authors.initials: N
authors.lastname: Bunyapraphatsara
authors.forename: P
authors.initials: P
authors.lastname: Moongkarndi
mesh_terms: D016604:Aflatoxin B1 / Q000037:antagonists & inhibitors; D000873:Anthracenes; D016587:Antimutagenic Agents / Q000737:chemistry / Q000494:pharmacology*; D001386:Azides; D002470:Cell Survival / Q000187:drug effects; D004128:Dimethylnitrosamine / Q000037:antagonists & inhibitors; D047309:Flavones; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D008862:Microsomes, Liver / Q000201:enzymology; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D019810:Sodium Azide; D013489:Suppression, Genetic; D013876:Thiophenes
chemical_list: D000873:Anthracenes; D016587:Antimutagenic Agents; D001386:Azides; D047309:Flavones; D005419:Flavonoids; D009153:Mutagens; D013876:Thiophenes; C078130:hortensin flavonoid; C028976:3-(5-nitro-2-thienyl)-2-(2-furyl)acrylamide; C006593:2-anthramine; D019810:Sodium Azide; D016604:Aflatoxin B1; D004128:Dimethylnitrosamine; C055957:hispidulin