Effects of phenothiazine and thiabendazole on bovine dorsal pedal vein contractility induced by ergonovine and serotonin; potential for alleviation of fescue toxicity.
Phenothiazine and thiabendazole were studied for their ability to antagonize venoconstriction induced by ergonovine, and the biogenic amine serotonin, in the isolated dorsal pedal vein of cattle. The two compounds are commercially available, approved for usage in cattle and have been reported to reverse some of the toxic effects associated with the intake of Acremonium coenophialum-infested fescue forage by cattle. Neither compound had any antagonistic activity against venoconstriction induced by ergonovine. However, thiabendazole did have some activity against venoconstriction induced by serotonin. Ergot alkaloids are known to cause venoconstriction through effects on biogenic amine receptors, including serotonergic receptors, and since thiabendazole has anti-serotonin activity, part of the reported beneficial effects of thiabendazole in alleviating fescue toxicity may be due to the anti-serotonin activity of the drug. Further work is needed to determine if phenothiazine and thiabendazole have any effect on other types of alkaloids that are present in A. coenophialum-infested fescue.
Oliver
J W
JW
Department of Environmental Practice, College of Veterinary Medicine, University of Tennessee, Knoxville 37901.
Robinson
A J
AJ
Abney
L K
LK
Linnabary
R D
RD
D000164:Acremonium / Q000254:growth & development; D000818:Animals; D002417:Cattle; D004874:Ergonovine / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors; D005528:Foot / Q000098:blood supply; D010640:Phenothiazines / Q000494:pharmacology*; D006109:Poaceae / Q000382:microbiology; D011292:Premedication; D012702:Serotonin Antagonists; D013827:Thiabendazole / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects*; D014680:Veins / Q000187:drug effects* / Q000502:physiology
D010640:Phenothiazines; D012702:Serotonin Antagonists; C031637:phenothiazine; D013827:Thiabendazole; D004874:Ergonovine