title: [Asymmetric synthesis of nitrogen-containing biologically active compounds utilizing intramolecular aminocyclization to olefin of secondary allylic alcohols].
abstract: The progress of the asymmetric syntheses of nitrogen-containing biologically active compounds such as pyrrolidine, pyrrolizidine, indolizidine alkaloids, and unusual amino acids has been reviewed. Our recent advances in taking advantage of stereoselective aminocyclization of homochiral N-alkenyl urethanes and thioimitates containing allylic hydroxyl group have provided an attractive entry into the functionalized pyrrolidine skeletons as chiral building blocks. A promising approach to a number of biologically active compounds such as alkaloids has emerged.
authors.affiliation: Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Takahata
mesh_terms: D000433:1-Propanol / Q000737:chemistry; D000475:Alkenes / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry*; D020005:Propanols
chemical_list: D000475:Alkenes; D020005:Propanols; C006463:allyl alcohol; D000433:1-Propanol; D009584:Nitrogen