title: [Immunological reactions in patients with pulmonary aspergilloma].
abstract: A 52-year-old man with pulmonary aspergilloma is reported. In immunoassays, type I, III and IV hypersensitivity reactions of Gell & Coombs were observed. The finding of such immunological reactions, especially type I hypersensitivity, has rarely been observed in this disease. The present study was performed to investigate these reactions, especially to determine whether type I allergy participates in pulmonary aspergilloma. We reviewed 126 cases of pulmonary aspergilloma reported in the Japanese literature between January 1980 and April 1991. The following results were obtained: Elevation of serum IgE was observed in 49% of the subjects examined, positive IgE RAST score in 28%, precipitating antibody against A. fumigatus in 79%, and positive lymphocyte stimulation test using A. fumigatus antigen in 68%. In conclusion, type I, III and IV hypersensitivity of Gell & Coombs appears to participate in pulmonary aspergilloma. The occurrence of type I hypersensitivity is not rare in this disease.
authors.affiliation: Department of Internal Medicine and Surgery, Ehime Prefectural Niihama Hospital, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ichiki
authors.forename: M
authors.initials: M
authors.lastname: Shishido
authors.forename: M
authors.initials: M
authors.lastname: Yano
mesh_terms: D001229:Aspergillosis, Allergic Bronchopulmonary / Q000276:immunology*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007073:Immunoglobulin E / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011852:Radioallergosorbent Test
chemical_list: D007073:Immunoglobulin E