title: Undifferentiated (embryonal) sarcoma of the liver: report of three cases.
abstract: Undifferentiated (embryonal) sarcoma is a rare malignant tumor of the liver. It typically presents in late childhood and its prognosis is poor. We experienced three cases of such a tumor during the period of 1976-1989; two of these patients are still alive without disease. Each case was independently treated with a combination of surgery and pre- and/or postoperative chemotherapy, which was found to be effective. In one surviving patient, cyclophosphamide and vincristine were found to be effective, while in the other a combination of cisplatin, Adriamycin (ADM), vincristine and cyclophosphamide was observed to induce a rapid reduction in the size of the recurrent tumor. Thus, an adequate combination of surgery and chemotherapy may improve the prognosis of this tumor.
authors.affiliation: Department of Pediatric Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kadomatsu
authors.forename: A
authors.initials: A
authors.lastname: Nakagawara
authors.forename: Y
authors.initials: Y
authors.lastname: Zaizen
authors.forename: M
authors.initials: M
authors.lastname: Nagoshi
authors.forename: M
authors.initials: M
authors.lastname: Tsuneyoshi
authors.forename: T
authors.initials: T
authors.lastname: Fukushige
authors.forename: A
authors.initials: A
authors.lastname: Haigou
authors.forename: S
authors.initials: S
authors.lastname: Suita
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D002648:Child; D002675:Child, Preschool; D002945:Cisplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D008297:Male; D008637:Mesenchymoma / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D011379:Prognosis; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin