Calprotectin in patients with rheumatoid arthritis: relation to clinical and laboratory variables of disease activity.
Calprotectin (L1) is a major granulocyte and monocyte protein which is released during activation of these cells. The plasma level of L1 is thought to reflect disease activity in rheumatoid arthritis (RA). In our cross sectional study of 70 patients with RA, L1 had significant correlations with erythrocyte sedimentation rate (r = 0.50), C-reactive protein (r = 0.58), orosomucoid (r = 0.62), platelet count (r = 0.42), leukocyte count (r = 0.33) and IgM rheumatoid factor (r = 0.32); and with the following clinical variables: number of swollen joints (r = 0.24), grip strength (r = -0.22), PIP joint circumferences (r = 0.33) and a combined global assessment score (r = 0.24). L1 was higher in seropositive (median 14,861 micrograms/l) than seronegative patients (median 10,487 micrograms/l) (p less than 0.03).
Brun
J G
JG
Department of Rheumatology, Haukeland Hospital, Bergen, Norway.
Haga
H J
HJ
Bøe
E
E
Kallay
I
I
Lekven
C
C
Berntzen
H B
HB
Fagerhol
M K
MK
D000293:Adolescent; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D015816:Cell Adhesion Molecules, Neuronal / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007596:Joints / Q000473:pathology; D007958:Leukocyte Count; D039841:Leukocyte L1 Antigen Complex; D008297:Male; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D009961:Orosomucoid / Q000032:analysis; D010976:Platelet Count; D012217:Rheumatoid Factor / Q000032:analysis; D012720:Severity of Illness Index
D015415:Biomarkers; D015816:Cell Adhesion Molecules, Neuronal; D007075:Immunoglobulin M; D039841:Leukocyte L1 Antigen Complex; D009961:Orosomucoid; D002097:C-Reactive Protein; D012217:Rheumatoid Factor