[Antistress and cardioprotective properties of the synthetic analog of endogenous opioids dalargin in experimental burn trauma in rats].
The author studied the effect of Dalargin on the dynamics of experimental burn trauma in Wistar rats, which was evaluated according to values of lethality, the level of stress ulcero-erosive affection of the gastric mucosa, and the degree of functional activity of an isolated perfused heart. The antistress effect of Dalargin, consisting in limitation of ulcer formation in the gastric mucosa, was determined by dose-temporal characteristics which made it possible to develop the optimal schemes of Dalargin administration in the treatment of a burn trauma. This was manifested by reduced lethality among the experimental rats compared to that among the controls and marked limitation of stress ulcer formation and by significantly diminished cardiodepressive effect of burn toxemia. Besides, the protective effect of Dalargin was connected with the direct formation of resistance to hypoxia of the myocardium of rats with burns.
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D000818:Animals; D002056:Burns / Q000188:drug therapy* / Q000503:physiopathology; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000188:drug therapy* / Q000209:etiology
D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Antistressornye i kardioprotektivnye svoĭstva sinteticheskogo analoga éndogennykh opioidov dalargina pri éksperimental'noĭ ozhogovoĭ travme u krys.