Alcohol can inhibit effect of IL-4 on activated murine B cells.
Ethanol addition to B lymphocytes in vitro inhibits antigen-induced antibody secretion and antigen-induced cell proliferation. We tested the hypothesis that ethanol can inhibit the effect of interleukins on B-cell proliferation by adding ethanol to in vitro functional assays for IL-2 and IL-4. Ethanol does not inhibit IL-2-induced B-cell differentiation, but it does inhibit IL-4-induced B-cell proliferation and IL-4-induced Ig class switching.
Aldo-Benson
M
M
Department of Medicine, Indiana University School of Medicine, Indianapolis 46202-5103.
Pratt
L
L
Hardwick
J
J
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects*; D002454:Cell Differentiation / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D007074:Immunoglobulin G / Q000378:metabolism; D007376:Interleukin-2 / Q000494:pharmacology; D015847:Interleukin-4 / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000166:cytology; D013950:Thymus Gland / Q000166:cytology
D007074:Immunoglobulin G; D007376:Interleukin-2; D008070:Lipopolysaccharides; D015847:Interleukin-4; D000431:Ethanol