title: [Benign familial neonatal convulsions in a family with one member with infantile spasms].
abstract: A pedigree of benign familial neonatal convulsions (BFNC) was reported. Seven members of two generations experienced convulsions in the neonatal period and/or in early infancy. All of these members except one had a good prognosis. One member who had infantile spasms was uneventfully delivered at 37 weeks of gestation, with a birth weight of 2,562 g and, without trouble during pregnancy. At the age of 20 days, she began to have adversive seizures. Later, she developed complex partial seizures and infantile spasms at 1 month and 10 days of age. Interictal EEG showed hypsarrhythmia. Biochemical investigations and MRI of the head revealed no abnormality. Treatment with sodium valproate and carbamazepine succeeded in stopping the seizures and she had no seizures after 3 months. But her psychomotor development was moderately delayed at 8 months. No case with severe epilepsy such as infantile spasms has been reported in the previous literature on BFNC. From our experience, early treatment and careful follow-up are considered to be important for BFNC.
authors.affiliation: Department of Pediatrics, Social Insurance Ritsurin Hospital, Takamatsu.
authors.forename: K
authors.initials: K
authors.lastname: Mori
authors.forename: I
authors.initials: I
authors.lastname: Yano
authors.forename: T
authors.initials: T
authors.lastname: Hashimoto
mesh_terms: D002648:Child; D002675:Child, Preschool; D005192:Family Health; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010375:Pedigree; D012640:Seizures / Q000235:genetics*; D013036:Spasms, Infantile / Q000235:genetics*