[Teratogenic action of alpha-asarone in the mouse].
The embryotoxicity and teratogenicity of alpha-asarone were investigated in mice. The drug was dissolved in corn oil, and administered daily, by gavage, on days 6 to 15 of gestation, at 0 (controls), 5, 15, 30 and 60 mg/kg. Fetuses were removed on day 18 by caesarean section and examined using routine teratological methods. A significant maternal toxicity was observed in dams given 60 mg/kg, as indicated by a reduced weight gain. An embryolethality was observed in 15, 30 and 60 mg/kg treated groups. In addition, the highest dose induced fetal malformations, mainly represented by hydrocephaly, extra-ribs, clubfeet and cleft lips.
Salazar
M
M
Département de Pharmacie, Ecole Nationale des Sciences Biologiques, IPN, Mexico D.F., Mexique.
Salazar
S
S
Ulloa
V
V
Mendoza
T
T
Pages
N
N
Chamoro
G
G
D000014:Abnormalities, Drug-Induced; D000081248:Allylbenzene Derivatives; D000818:Animals; D000840:Anisoles / Q000008:administration & dosage / Q000633:toxicity*; D002273:Carcinogens / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005865:Gestational Age; D051379:Mice; D011247:Pregnancy; D015430:Weight Gain
D000081248:Allylbenzene Derivatives; D000840:Anisoles; D002273:Carcinogens; C012195:asarone
Action tératogène de l'alpha-asarone chez la souris.