title: Subchronic toxicity studies of fenbendazole in rats.
abstract: The effects of prolonged exposure of rats to fenbendazole were investigated. Fenbendazole was given daily by gavage for 14 consecutive days. These dosages (3000, 500 or 50 mg/kg/d) produced reductions in body weight gains. Renal tubular hyperemia or hemorrhage and glomerular capsule dilation, increased serum creatinine and hepatocellular granular degeneration occurred at dosages of 500 and 3000 mg/kg/d. Renal tubular epithelial cell granular degeneration and tubular dilation, increased serum glutamic pyruvic transaminase, cardiac hemorrhage and granular degeneration also occurred at 3000 mg/kg/d.
authors.affiliation: Laboratory of Pharmacology and Toxicology, National Control Institute of Veterinary Bioproducts and Pharmaceuticals, Beijing, China.
authors.forename: S X
authors.initials: SX
authors.lastname: Xu
authors.forename: D
authors.initials: D
authors.lastname: Zheng
authors.forename: Y M
authors.initials: YM
authors.lastname: Sun
authors.forename: S H
authors.initials: SH
authors.lastname: Wang
authors.forename: L Q
authors.initials: LQ
authors.lastname: Shao
authors.forename: Q Y
authors.initials: QY
authors.lastname: Huang
authors.forename: D L
authors.initials: DL
authors.lastname: Xiang
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D005273:Fenbendazole / Q000633:toxicity*; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D008107:Liver Diseases / Q000097:blood / Q000473:pathology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D005273:Fenbendazole