Lupus nephritis in a pediatric renal transplant recipient.
A case of aggressive lupus nephritis in a pediatric renal transplant patient is described. She initially presented with end-stage glomerulonephritis for which an underlying etiology could not be determined. Ten months after cadaveric renal transplantation, systemic lupus erythematosus was diagnosed, when she developed diffuse proliferative glomerulonephritis in association with antinuclear antibody, anti-double-stranded DNA antibody and extrarenal manifestations of lupus. It is plausible that she developed recurrent rather than de novo lupus nephritis following transplantation. Reactivation of lupus nephritis in a renal transplant is unusual in adults, and is previously unreported in children.
Fox
L
L
Department of Medicine, University of New Mexico School of Medicine, Albuquerque 87131.
Zager
P G
PG
Harford
A M
AM
Tung
K S
KS
Smith
S M
SM
D000906:Antibodies / Q000032:analysis / Q000276:immunology; D000974:Antibodies, Antinuclear / Q000032:analysis; D002648:Child; D004247:DNA / Q000276:immunology; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology; D016030:Kidney Transplantation / Q000009:adverse effects*; D008180:Lupus Erythematosus, Systemic / Q000209:etiology / Q000276:immunology; D008181:Lupus Nephritis / Q000209:etiology* / Q000276:immunology
D000906:Antibodies; D000974:Antibodies, Antinuclear; D004247:DNA