title: Interactions of bioactive lipopeptides, iturin A and surfactin from Bacillus subtilis.
abstract: The antifungal activity of iturin A and its interaction with erythrocyte membranes were enhanced in the presence of surfactin. The modification of the properties of iturin A was explained by the formation of mixed iturin A-surfactin micelles. Such mixed micelles were easily generated when both lipopeptides were in aqueous solutions in the absence of mineral salts but the formation of these micelles did not occur when the solutions contained a high molarity of mineral cations.
authors.affiliation: Laboratoire de Biochimie Microbienne, Université Lyon 1, Villeurbanne, France.
authors.forename: L
authors.initials: L
authors.lastname: Thimon
authors.forename: F
authors.initials: F
authors.lastname: Peypoux
authors.forename: R
authors.initials: R
authors.lastname: Maget-Dana
authors.forename: B
authors.initials: B
authors.lastname: Roux
authors.forename: G
authors.initials: G
authors.lastname: Michel
mesh_terms: D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D001412:Bacillus subtilis; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D004357:Drug Synergism; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D006461:Hemolysis; D006801:Humans; D055666:Lipopeptides; D008969:Molecular Sequence Data; D010455:Peptides; D010456:Peptides, Cyclic / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000187:drug effects*; D013050:Spectrometry, Fluorescence; D013500:Surface Tension
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001426:Bacterial Proteins; D055666:Lipopeptides; D010455:Peptides; D010456:Peptides, Cyclic; C009365:surfactin peptide; C013579:iturin A