Medical treatment of Cushing's syndrome with aminoglutethimide and ketoconazole.
We report a 54-year-old Chinese man with Cushing's syndrome from bilateral adrenal adenomata in whom surgery was contraindicated because of his intercurrent medical conditions. Instead, he was successfully treated with aminoglutethimide 0.75 gm/day (which reduced his 24-hour urinary free cortisol from 628 nmol/day to 177 nmol/day in 4 weeks), followed by ketoconazole 0.6 gm/day which continued to suppress the urinary free cortisol level. We conclude that aminoglutethimide or ketoconazole offers a viable non-surgical alternative to the treatment of Cushing's syndrome.
Kong
H L
HL
Department of Medicine, National University Hospital, Singapore.
Lee
K O
KO
Cheah
J S
JS
D000236:Adenoma / Q000150:complications; D000310:Adrenal Gland Neoplasms / Q000150:complications; D000616:Aminoglutethimide / Q000008:administration & dosage / Q000627:therapeutic use*; D003480:Cushing Syndrome / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000652:urine; D007654:Ketoconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000150:complications
D000616:Aminoglutethimide; D007654:Ketoconazole; D006854:Hydrocortisone