title: Noninvasive acoustical detection of coronary artery disease using the adaptive line enhancer method.
abstract: Previous studies have indicated that heart sounds may contain information which is useful in the detection of occluded coronary arteries. Specifically, previous work based on analysing heart sounds recorded during the diastolic portion of the cardiac cycle, when blood flow through the coronary arteries is maximum, has shown that additional frequency components are present in patients with coronary artery disease. To further explore the application of advanced signal processing techniques to the noninvasive detection of coronary artery disease, a new signal-processing approach is presented using adaptive line enhancing (ALE) and spectral estimation of diastolic heart sounds taken from recordings made at the patient's bedside. This approach comprises two cascaded processes. In the first the ALE method is used to enhance the diastolic heart sounds and eliminate background noise. In the second process, either autoregressive (AR) or autoregressive moving average (ARMA) spectral methods are used to estimate the model parameters. Model parameters (the power spectral density (PSD) functions and the poles of the AR or ARMA method) were used to diagnose patients as diseased or normal. Results showed that normal and abnormal recordings were correctly identified in 39 of 43 cases using the new method. These results also confirm that high-frequency energy above 400 Hz is associated with coronary stenosis.
authors.affiliation: Biomedical Engineering Department, Rutgers State University, Piscataway, NJ 08855.
authors.forename: M
authors.initials: M
authors.lastname: Akay
authors.forename: W
authors.initials: W
authors.lastname: Welkowitz
authors.forename: J L
authors.initials: JL
authors.lastname: Semmlow
authors.forename: Y M
authors.initials: YM
authors.lastname: Akay
authors.forename: J
authors.initials: J
authors.lastname: Kostis
mesh_terms: D003327:Coronary Disease / Q000175:diagnosis*; D006326:Heart Auscultation / Q000379:methods*; D006801:Humans; D012815:Signal Processing, Computer-Assisted