[The effect of grofollon on the induction of sex maturation in female rats].
The authors provide the results of experimental studies carried out in immature female rats given the gonadotropin grofollon to stimulate puberty. Grofollon was administered in doses of 20, 30 or 50 units. It was dissolved in a physiological solution or prolongon. The effect of grofollon was found to depend on the dose and type of the solvent. The earliest response (in 6 hours) to grofollon administration was marked by an increase of plasma estradiol. 24 hours after the hormonal treatment there was a rise of the mass of the ovaries and uterus, in particular. The vagina opened on the 3d day. The dissolution of grofollon in prolongon was discovered to enhance the drug efficacy.
Gladkova
A I
AI
Alesina
M Iu
MIu
Karpenko
N A
NA
Ostashko
F I
FI
Isachenko
V V
VV
D000818:Animals; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D004967:Estrogens / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012741:Sexual Maturation / Q000187:drug effects*; D012996:Solutions; D014599:Uterus / Q000187:drug effects; D014621:Vagina / Q000187:drug effects
D003692:Delayed-Action Preparations; D004967:Estrogens; D012996:Solutions; D005640:Follicle Stimulating Hormone
Vliianie grofollona na induktsiiu polovozrelosti u krys-samok.