title: Pharmacology, bio-analysis and pharmacokinetics of the vinca alkaloids and semi-synthetic derivatives (review).
abstract: Vinca alkaloids have been used as chemotherapeutic agents now for over three decades. Especially during recent years, the development of a considerable number of semi-synthetic derivatives, showing attractive properties in preclinical or clinical investigations, has been reported. In this paper we shall give a critical review of the investigations presented on this matter.
authors.affiliation: Department of Clinical Chemistry, Netherlands Cancer Institute, Amsterdam.
authors.forename: O
authors.initials: O
authors.lastname: van Tellingen
authors.forename: J H
authors.initials: JH
authors.lastname: Sips
authors.forename: J H
authors.initials: JH
authors.lastname: Beijnen
authors.forename: A
authors.initials: A
authors.lastname: Bult
authors.forename: W J
authors.initials: WJ
authors.lastname: Nooijen
mesh_terms: D000818:Animals; D001692:Biological Transport; D006801:Humans; D013329:Structure-Activity Relationship; D014748:Vinca Alkaloids / Q000378:metabolism / Q000493:pharmacokinetics* / Q000494:pharmacology*
chemical_list: D014748:Vinca Alkaloids