Down-regulating effect on cellular immunity of the NSF17 factor produced by murine neonatal spleen cells fused with BW 5147 thymoma cells.
The non-specific factor NSF17 produced by mouse newborn splenocytes fused with BW 5147 thymoma cells was tested in vivo for its immunosuppressive activity. NSF17 administered i.p. in a single dose into adult mice significantly decreased the PHA-induced proliferative response of lymphocytes, regional graft-versus-host reaction, and delayed-type hypersensitivity.
Bubak-Satora
M
M
Department of Immunobiology, Polish Academy of Sciences, Kraków.
Machala
O
O
Kubera
M
M
Mazur-Kolecka
B
B
Skowron-Cendrzak
A
A
D000818:Animals; D000831:Animals, Newborn; D006087:Graft vs Host Reaction / Q000276:immunology; D006825:Hybridomas; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D051379:Mice; D008808:Mice, Inbred CBA; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000276:immunology*; D013491:Suppressor Factors, Immunologic / Q000502:physiology*; D013945:Thymoma / Q000473:pathology
D013491:Suppressor Factors, Immunologic