[Decrease of CD16 antigen density on granulocytes in chronic myeloid leukemia].
We examined the fluorescence intensity of CD16 antigen, which represents the density of CD16 antigen, on granulocytes by flow cytometry in 15 healthy subjects and 15 patients with neutrophilia due to inflammatory diseases and 10 patients with chronic myeloid leukemia (CML). The fluorescence intensity of CD16 antigen was significantly lower in patients with CML than in healthy subjects and also than in patients with neutrophilia. These data indicate that 1) density of CD16 antigen on granulocytes decrease in CML, and 2) analysis on the density of granulocyte CD16 antigen is useful for differential diagnosis of CML from inflammatory diseases with neutrophilia.
Kabutomori
O
O
Central Laboratory for Clinical Investigation, Osaka University Hospital.
Koh
T
T
Iwatani
Y
Y
Fushimi
R
R
Amino
N
N
Miyai
K
K
D005434:Flow Cytometry; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis* / Q000276:immunology; D017452:Receptors, IgG / Q000032:analysis*
D017452:Receptors, IgG