[Effect of doxorubicin on the functional state of the mononuclear phagocyte system].
The response of the system of mononuclear phagocytes (SMP) to doxorubicin, an antitumor antibiotic, most widely used in oncological care, was studied. It was shown that a single intraperitoneal administration of doxorubicin to CBA mice in the maximum tolerance doses induced suppression of absorptive SMP capacity and increased IL-I secretion by the bone marrow and peritoneal macrophages both in the stimulated and spontaneous tests in early periods after cytostatic administration. There was a significant rise in the ability of SMP bone marrow elements to respond to the macrophage activating factor, as well as an increase in the cytotoxic activity of bone marrow and peritoneal macrophages.
Evtushenko
O M
OM
Karpova
G V
GV
Zhdanov
V V
VV
Gol'dberg
E D
ED
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology*; D001854:Bone Marrow Cells; D004317:Doxorubicin / Q000494:pharmacology*; D005260:Female; D007166:Immunosuppressive Agents; D007375:Interleukin-1 / Q000378:metabolism*; D008262:Macrophage Activation / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008808:Mice, Inbred CBA; D008954:Models, Biological; D009000:Monocytes / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D010587:Phagocytosis / Q000187:drug effects* / Q000276:immunology; D013268:Stimulation, Chemical; D013997:Time Factors
D007166:Immunosuppressive Agents; D007375:Interleukin-1; D004317:Doxorubicin
Vliianie doksorubitsina na funktsional'noe sostoianie sistemy mononuklearnykh fagotsitov.