Nude mouse interim host model for human parathyroid grafts. II. Alteration of MHC antigens in human PTG grafts in the nude mouse.
Human parathyroid (PTG) tissues from cadaver (C-PTG), 5-month fetus (F-PTG) and PTG adenoma (A-PTG) were transplanted into the kidney subcapsular areas of Balb/C nude mice as interim host. Dynamic changes in the amount of tissue major histocompatibility complex (MHC) antigen present within the transplantation period were observed. The results showed that during 100 days of interim hosting, no obvious changes in the expression of tissue MHC class I antigens were seen, but the expression of tissue MHC class II antigens was significantly reduced. The changes of MHC antigens in different donor human PTG tissues were compared.
Gao
Z
Z
PUMC Hospital, CAMS, Beijing.
Zhu
Y
Y
Yao
C
C
Li
D
D
Han
S
S
D000236:Adenoma / Q000276:immunology*; D000818:Animals; D002102:Cadaver; D005333:Fetus; D006684:HLA-DR Antigens / Q000378:metabolism*; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D010280:Parathyroid Glands / Q000276:immunology / Q000637:transplantation; D010282:Parathyroid Neoplasms / Q000276:immunology*; D013370:Subrenal Capsule Assay
D006684:HLA-DR Antigens; D015395:Histocompatibility Antigens Class I