Cardioprotection of ACE inhibitor in ischemic heart is not dependent on the local angiotensin II formation.
Angiotensin II (AII) and bradykinin (BK) release into anterior interventricular vein (AIV) increased significantly 30 minutes after left anterior descending artery (LAD) occlusion in the absence of kidneys. Captopril enhanced BK release, but did not suppress the increase of AII release. Nafamostat suppressed both releases. Infarct size was significantly reduced by captopril but not by nafamostat. These results suggest that cardioprotective effect of captopril might be dependent on local BK accumulation, but not on suppression of local AII generation.
Noda
K
K
Department of Internal Medicine, Fukuoka University, Japan.
Sasaguri
M
M
Ideishi
M
M
Ikeda
M
M
Arakawa
K
K
D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D001550:Benzamidines; D001794:Blood Pressure / Q000187:drug effects; D001920:Bradykinin / Q000378:metabolism*; D002216:Captopril / Q000494:pharmacology*; D002302:Cardiac Output / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D003331:Coronary Vessels / Q000502:physiology; D004285:Dogs; D006146:Guanidines / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects* / Q000502:physiology / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects*; D007610:Kallikreins / Q000037:antagonists & inhibitors*; D008297:Male; D009203:Myocardial Infarction / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism*; D014655:Vascular Resistance / Q000187:drug effects
D001550:Benzamidines; D006146:Guanidines; D000804:Angiotensin II; D002216:Captopril; D007610:Kallikreins; D001920:Bradykinin; C032855:nafamostat