Intraperitoneal injection of dipyridamole increases the life span of tumor bearing mice treated with fluorouracil.
This study was carried out to investigate the effect of the Fluorouracil (5-FU) and Dipyridamole (DP) combination on the growth of P388 murine lymphoid neoplasms. The first stage was to determine the lethal dose (LD 50) for each compound (5-FU, DP) to normal B6D2F1 mice after intraperitoneal (i.p.) injection. The LD 50 were 700 and 54 mg/kg for DP and 5-FU respectively. B6D2F1 mice bearing P388 ascitic tumors and receiving a 4-day schedule of 5-FU (2 mg/kg/day) with DP (100 mg/kg/day) 1 hr before each 5-FU dose were studied. DP was found to lower significantly (p < 0.0001) the mortality of 5-FU in tumor bearing mice by nearly 2.5 fold. This study aims at defining the best dose combination of intraperitoneal injection of 5-FU in conjunction with DP. These data allow a prospective evaluation of 4-day, i.p. 5-FU and DP with an increase of life span without toxic death.
Barberl-Heyob
M
M
Centre Alexis Vautrin, Laboratoire de Recherche, Vandoeuvre Les Nancy, France.
Merlin
J L
JL
Weber
B
B
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001692:Biological Transport / Q000187:drug effects; D004261:DNA Replication / Q000187:drug effects; D004176:Dipyridamole / Q000008:administration & dosage / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D007941:Leukemia P388 / Q000188:drug therapy*; D051379:Mice; D009705:Nucleosides / Q000378:metabolism; D011446:Prospective Studies
D009705:Nucleosides; D004176:Dipyridamole; D005472:Fluorouracil