Effects of m-nisoldipine on transmembrane currents of guinea pig papillary muscles.
Effects of m-Nis on the transmembrane currents were studied using single sucrose gap voltage clamp technique. The amplitude of slow inward current (I(si)) was 10.6 +/- 4.1 microA. Maximal inward current was induced at a membrane potential range between -20 to -25 mV. The amplitude of I(si) were significantly decreased by m-Nis (0.2 mumol.L-1) with a reduction of 47.3%. The transient inward current (I(ti)) induced by ouabain was also greatly depressed or prevented by m-Nis, resulting in the inhibition of DAD.
An
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RH
Department of Physiology, Hebei Medical College, Shijiazhuang, China.
Fan
Z Z
ZZ
He
R R
RR
D000818:Animals; D004594:Electrophysiology; D005260:Female; D006168:Guinea Pigs; D007536:Isomerism; D008297:Male; D008564:Membrane Potentials; D015737:Nisoldipine / Q000494:pharmacology*; D010042:Ouabain / Q000037:antagonists & inhibitors; D010210:Papillary Muscles / Q000502:physiology*
D015737:Nisoldipine; D010042:Ouabain