Comparison of plasma levels of lipid hydroperoxides and antioxidants in hyperlipidemic Nagase analbuminemic rats, Sprague-Dawley rats, and humans.
The levels of lipid hydroperoxides and antioxidants in plasma samples from Nagase analbuminemic rats (NAR) and control Sprague-Dawley rats (SDR) were measured in comparison with those from normal human subjects. Cholesteryl ester hydroperoxide (CE-OOH) was detected, but phosphatidylcholine hydroperoxide was not. The levels of CE-OOH and the ratios of CE-OOH/CE were found to increase significantly in the order of human < SDR < NAR, suggesting that oxidative stress increases in the same order. NAR have a significantly lower level of ascorbate and lower ratio of ubiquinol/ubiquinone concentrations than SDR. This also suggests that NAR are subject to more oxidative stress than SDR, since ascorbate and ubiquinol are the most effective plasma antioxidants against oxygen radicals.
Yamamoto
Y
Y
Department of Reaction Chemistry, Faculty of Engineering, University of Tokyo, Japan.
Wakabayashi
K
K
Niki
E
E
Nagao
M
M
D000328:Adult; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood*; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D051381:Rats; D011922:Rats, Mutant Strains; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D012709:Serum Albumin / Q000172:deficiency*
D000975:Antioxidants; D008054:Lipid Peroxides; D012709:Serum Albumin