[Effect of hypotensive anesthesia on tissue oxygen tension of the heart, kidney and liver].
The effects of hypotensive anesthesia by prostaglandin E1 (PGE1: 8 dogs) or trimetaphan (TMP: 8 dogs) on tissue oxygenation were studied in 16 mongrel dogs anesthetized with pentobarbital. Mean blood pressure (MBP), heart rate (HR), cardiac output (CO), blood gases (BG), the blood flow and tissue oxygen tension of the heart, the kidney and the liver were measured. The blood flow and oxygen tension were measured by electromagnetic flowmeters and by polarographic oxygen electrodes respectively. PGE1 or TMP was injected intravenously to decrease MBP by 30%. MBP, CO, HR and BG of PGE1 were not significantly different with those of TMP. Coronary blood flow decreased for 12% with PGE1 and for 33% with TMP. Though blood flows of the renal and the hepatic arteries were well maintained with PGE1, they decreased for 36% and 34% respectively with TMP. Oxygen tensions of the myocardium (both outer and inner layers) and the liver were well maintained with PGE1. But with TMP, oxygen tension decreased for 23% in outer layer, for 16% in inner layer and for 31% in the liver. Oxygen tension of the kidney remained unchanged with PGE1 and TMP. The results suggest that PGE1 is more useful for the maintenance of the tissue oxygenation than TMP during hypotensive anesthesia.
Hashimoto
K
K
Department of Anesthesia, Yokohama City University Urahune Hospital.
Okazaki
K
K
Okutsu
Y
Y
Tateyama
T
T
Okumura
F
F
D000758:Anesthesia; D000818:Animals; D004285:Dogs; D006321:Heart / Q000502:physiology*; D007023:Hypotension, Controlled; D007668:Kidney / Q000502:physiology*; D008099:Liver / Q000502:physiology*; D010101:Oxygen Consumption / Q000502:physiology*