Arterial thrombosis and protein S deficiency.
A previously healthy boy had progressive painful discoloration of the lower extremities and was treated with exchange transfusion and anticoagulation, which were unsuccessful in arresting pedal ischemia; amputation of all of the child's toes was required. Studies of the patient and his parents resulted in a diagnosis of inherited protein S deficiency.
Horowitz
I N
IN
Department of Pediatrics, Childrens Hospital Los Angeles 90027.
Galvis
A G
AG
Gomperts
E D
ED
D000671:Amputation, Surgical; D002648:Child; D003490:Cyanosis / Q000175:diagnosis / Q000209:etiology / Q000601:surgery; D005528:Foot / Q000098:blood supply*; D006801:Humans; D007511:Ischemia / Q000175:diagnosis / Q000209:etiology / Q000601:surgery; D008297:Male; D011486:Protein C / Q000032:analysis; D017293:Protein S / Q000097:blood; D018455:Protein S Deficiency; D013927:Thrombosis / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D014034:Toes / Q000601:surgery
D011486:Protein C; D017293:Protein S