[The antioxidizing activity of malonic acid derivatives].
Nine newly synthesized malonic acid derivatives were shown to have antioxidizing activity which makes up from 30 to 60% of the antioxidizing activity of ionol and vitamin E in vitro and does not yield to the activity of the latter substances in vivo. It is suggested that malonic acid derivatives may influence the antioxidizing enzymes--catalase, glucose-6-phosphate dehydrogenase and superoxide dismutase.
Dorovskikh
V A
VA
Zrazhevskaia
E V
EV
Borodin
E A
EA
Borodina
G P
GP
D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D002084:Butylated Hydroxytoluene / Q000494:pharmacology / Q000627:therapeutic use; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy / Q000378:metabolism; D003080:Cold Temperature / Q000009:adverse effects; D004353:Drug Evaluation, Preclinical; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008314:Malonates / Q000494:pharmacology* / Q000627:therapeutic use; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D014810:Vitamin E / Q000494:pharmacology / Q000627:therapeutic use
D000975:Antioxidants; D008314:Malonates; D014810:Vitamin E; D002084:Butylated Hydroxytoluene; C030290:malonic acid
Antiokislitel'naia aktivnost' proizvodnykh malonovoĭ kisloty.