title: Implications for the pathogenesis of aneurysm formation: metastatic choriocarcinoma with spontaneous splenic rupture. Case report and a review.
abstract: We report a case of ruptured intracranial aneurysm from metastatic choriocarcinoma in a patient presenting with intracerebral hemorrhage. Operative evacuation of the hematoma with clipping of a distal right middle cerebral artery aneurysm was performed. Postoperatively, the patient developed hypovolemic shock from spontaneous splenic rupture. Histopathologic examination of the cerebral aneurysm showed choriocarcinoma invading the vessel wall. Metastatic choriocarcinoma should be considered in the differential diagnosis of intracerebral or subarachnoid hemorrhage in women of child-bearing age.
authors.affiliation: Department of Neurosurgery, Hahnemann University, Philadelphia, PA 19102-1192.
authors.forename: G
authors.initials: G
authors.lastname: Giannakopoulos
authors.forename: S
authors.initials: S
authors.lastname: Nair
authors.forename: C
authors.initials: C
authors.lastname: Snider
authors.forename: P S
authors.initials: PS
authors.lastname: Amenta
mesh_terms: D000328:Adult; D017542:Aneurysm, Ruptured / Q000209:etiology / Q000601:surgery; D001932:Brain Neoplasms / Q000150:complications* / Q000556:secondary; D002543:Cerebral Hemorrhage / Q000209:etiology / Q000601:surgery*; D002822:Choriocarcinoma / Q000150:complications* / Q000556:secondary; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications / Q000209:etiology*; D011183:Postoperative Complications / Q000209:etiology; D012422:Rupture, Spontaneous; D013161:Splenic Rupture / Q000209:etiology*