D-cycloserine reverses the working memory impairment of hippocampal-lesioned rats in a spatial learning task.
It is shown that D-cycloserine has cognition-enhancing properties in quinolinic acid hippocampal-lesioned rats. Lesioned rats had a severe impairment of working memory in an allocentric spatial reversal paradigm in the 8-arm maze, and performance could be restored with 12 mg/kg i.p. D-cycloserine, given 30 min before testing. The present findings favour the testing of D-cycloserine for clinical efficacy in patients with Alzheimer's disease with loss of pyramidal neurons and disconnected glycine-NMDA receptor activation.
Schuster
G M
GM
Department of Pharmacology, Merz + Co.GmbH & Co., Frankfurt/Main, Germany.
Schmidt
W J
WJ
D000704:Analysis of Variance; D000818:Animals; D003072:Cognition Disorders / Q000188:drug therapy*; D003523:Cycloserine / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects*; D008297:Male; D008569:Memory Disorders / Q000188:drug therapy*; D017378:Quinolinic Acid / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley
D003523:Cycloserine; D017378:Quinolinic Acid