title: A miniature intraventricular axial flow blood pump that is introduced through the left ventricular apex.
abstract: A new intraventricular axial flow blood pump has been designed and developed as an implantable left ventricular assist device (LVAD). The pump consists of a tube housing (10 cm in length and 14 mm in diameter), a three-vane impeller combined with a guide vane, and a DC motor. This pump is introduced into the LV cavity through the LV apex, and the outlet cannula is passed antegrade across the aortic valve. Blood is withdrawn from the LV through the inlet ports at the pump base, and discharged into the ascending aorta. A pump flow of > 8 L/min was obtained against 90 mmHg differential pressure in the mock circulatory system. In an acute dog model, this pump could produce a sufficient output of 200 ml/kg/min. In addition, the pump flow profile demonstrated a pulsatile pattern, although the rotation speed was fixed. This is mainly due to the changes in flow rate during a cardiac cycle--that is, during systole, the flow rate increases to the maximum, while the differential pressure between the LV and the aorta decreases to the minimum. Thus, this simple and compact axial flow blood pump can be a potential LVAD, with prompt accessibility and need for less invasive surgical procedures.
authors.affiliation: Department of Cardiovascular Surgery, Tokyo Women's Medical College, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamazaki
authors.forename: M
authors.initials: M
authors.lastname: Umezu
authors.forename: H
authors.initials: H
authors.lastname: Koyanagi
authors.forename: M
authors.initials: M
authors.lastname: Kitamura
authors.forename: K
authors.initials: K
authors.lastname: Eishi
authors.forename: A
authors.initials: A
authors.lastname: Kawai
authors.forename: O
authors.initials: O
authors.lastname: Tagusari
authors.forename: H
authors.initials: H
authors.lastname: Niinami
authors.forename: T
authors.initials: T
authors.lastname: Akimoto
authors.forename: C
authors.initials: C
authors.lastname: Nojiri
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001783:Blood Flow Velocity; D001794:Blood Pressure; D004285:Dogs; D005069:Evaluation Studies as Topic; D006352:Heart Ventricles / Q000601:surgery; D006353:Heart-Assist Devices; D066298:In Vitro Techniques; D019736:Prostheses and Implants; D011474:Prosthesis Design