title: Temporary bile diversion in cats with experimental extrahepatic bile duct obstruction.
abstract: The use of a cholecystostomy catheter for temporary bile diversion was investigated in four cats with experimentally induced extrahepatic bile duct obstruction. Eighteen days after ligation of the common bile duct, a 6.5 F accordion catheter was placed in the gallbladder with a 22 g Hawkins needle-guide system through a paracostal incision. Biochemical parameters and fasting serum bile acids were monitored for 16 days. There were significant decreases in mean total bilirubin, aspartate aminotransferase, and fasting serum bile acids within 72 hours of bile diversion, and in mean alanine aminotransferase within 96 hours. Attitude and appetite improved, and the catheter was tolerated well. Positive bile cultures developed in three cats. Histologic changes in the gallbladder included mucosal ulcerations, a mixed inflammatory cellular infiltration, and fibrosis of the submucosa.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610.
authors.forename: D
authors.initials: D
authors.lastname: Lawrence
authors.forename: J R
authors.initials: JR
authors.lastname: Bellah
authors.forename: D J
authors.initials: DJ
authors.lastname: Meyer
authors.forename: L
authors.initials: L
authors.lastname: Roth
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001646:Bile / Q000737:chemistry; D001647:Bile Acids and Salts / Q000097:blood; D001663:Bilirubin / Q000097:blood; D002371:Cat Diseases / Q000601:surgery*; D002404:Catheterization / Q000662:veterinary*; D002408:Catheters, Indwelling / Q000662:veterinary; D002415:Cats; D001651:Cholestasis, Extrahepatic / Q000601:surgery / Q000662:veterinary*; D003135:Common Bile Duct / Q000601:surgery; D005704:Gallbladder / Q000473:pathology; D008026:Ligation / Q000662:veterinary; D012044:Regression Analysis; D015431:Weight Loss
chemical_list: D001647:Bile Acids and Salts; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin