title: The inverted Y-chromosome polymorphism in the Gujarati Muslim Indian population of South Africa has a single origin.
abstract: Y-specific polymorphisms were studied in Gujarati Muslim Indians possessing a Y-chromosome pericentric inversion [inv(Y)] in an attempt to prove a common genetic origin for the inversion. The p49a/TaqI and p49a/PvuII haplotypes were determined for 9 normal and 8 inv(Y) Gujarati Muslim men. Men with the inversion possessed identical TaqI and PvuII profiles, as opposed to 7 different TaqI and 8 different PvuII haplotypes observed in the 9 normal men. These results provide conclusive evidence for a common genetic origin of the inverted Y chromosome observed in this Gujarati Muslim community.
authors.affiliation: Department of Human Genetics, School of Pathology, South African Institute for Medical Research, Johannesburg.
authors.forename: A
authors.initials: A
authors.lastname: Spurdle
authors.forename: T
authors.initials: T
authors.lastname: Jenkins
mesh_terms: D007446:Chromosome Inversion; D006801:Humans; D007194:India / Q000208:ethnology; D007514:Islam; D008297:Male; D011110:Polymorphism, Genetic; D011897:Random Allocation; D013019:South Africa; D014998:Y Chromosome