Placental morphology and concentrations of glutathione (GSH and GSSG) and lipid peroxides (LPO) in two models of disturbed pregnancy of Uje:WIST rats.
Treatment of pregnant rats with heat-denaturated bacterial material (endotoxin-model) or exposure to chronic restraint of prenatally lithium-treated pregnant dams (stress-model) were used as two models of disturbed pregnancy, both causing decreased fetal body mass. The quotient of fetal/placental mass was lowered in the endotoxin-group only. Placental mass and protein content were not changed significantly in both experimental groups, although a tendency to smaller placentae was noticed in the stress-group. Placental histology of the stress-group did not differ from untreated controls. In the endotoxin-group an altered structure of the placental barrier was observed. Small decreases of GSH and GSSG in the endotoxin-group and of GSSG in the stress-group without significant changes of the GSH/GSSG relationship were measured in homogenates of the placental labyrinth. Moderate enhancement of LPO concentration occurred in the endotoxin-group and more distinctly in two litters of the stress-group, the latter being connected with high GSSG concentrations and low fetal/placental mass-quotients.
Braikow
G
G
Institute of Pharmacology and Toxicology, Friedrich-Schiller-Universität Jena, Germany.
Braekow-Bruzzi
S
S
Glöckner
R
R
Graf
R
R
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology; D005978:Glutathione / Q000032:analysis*; D008054:Lipid Peroxides / Q000032:analysis*; D010920:Placenta / Q000737:chemistry* / Q000473:pathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced / Q000473:pathology*; D011251:Pregnancy Complications, Infectious / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000139:chemically induced / Q000473:pathology*
D008054:Lipid Peroxides; D005978:Glutathione