Treatment of peripheral tissue ischemia with topical nitroglycerin ointment in neonates.
Four neonates had resolution of peripheral tissue ischemia after the application of 2% nitroglycerin ointment. A dosage of 4 mm nitroglycerin ointment per kilogram of body weight was applied to two patients with ischemia caused by vasospasm from indwelling radial artery catheterization and to two patients with ischemia resulting from dopamine extravasation. No adverse effects were noted except mild episodes of decreased blood pressure in two of the patients.
Wong
A F
AF
Division of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco 94143-0622.
McCulloch
L M
LM
Sola
A
A
D000287:Administration, Topical; D002408:Catheters, Indwelling / Q000009:adverse effects; D004298:Dopamine / Q000008:administration & dosage / Q000009:adverse effects; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000150:complications; D006225:Hand / Q000098:blood supply*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007511:Ischemia / Q000188:drug therapy* / Q000209:etiology; D005996:Nitroglycerin / Q000008:administration & dosage*; D009824:Ointments
D009824:Ointments; D005996:Nitroglycerin; D004298:Dopamine