title: [Progression to AIDS among HIV-seropositive hemophiliacs].
abstract: OBJECTIVE
  To assess the incidence of AIDS, along with its origin and mortality rate, in a group of sero-positive haemophiliacs with long follow-up.
  
  
  METHODS
  The progression into AIDS in 94 HIV-seropositive haemophiliacs (88 with haemophilia A and 6 with haemophilia B) followed since 1986 has been analyzed. The mean age was 19 years and 64% of the patients had severe haemophilia. All of them had been previously treated with non virus-inactivated factor concentrates. Was detected HIV antigen in 13 of them and 32 were treated with zidovudine. Actuarial analysis started from seroconversion date or from the first positive result and the average observation time was 90 months (5-97).
  
  
  RESULTS
  Sixteen patients developed AIDS, resulting in an eight-years accumulative actuarial indice of about 24%. AIDS incidence was lower (p less than 0.0001) in haemophilia A (21%) than in haemophilia B (67%). The eight-years progression rate to AIDS showed a significant dependence on patient age, it being higher in patients aged greater than 30 (77%) than in those aged 15-30 (30%) and less than 15 (9%). Patients who presented CD4+ counts lower than 0.5 x 10(9)/L or CD4/CD8 ratios lower than 0.5 at the beginning of the observation period had a greater 8-year AIDS incidence (63% and 57% respectively) than the remaining patients (16% and 12%). At AIDS diagnosis, all patients had CD4+ lymphocyte counts lower than 0.2 x 10(9)/L, two had detectable HIV antigenaemia and six had been previously treated with zidovudine. The cause of AIDS was an opportunistic infection in all the cases namely, P. carinii pneumonia and candidiasis, but no secondary neoplasia was registered. Nineteen patients died during the follow-up, 12 because of AIDS and 7 because of other reasons unrelated to HIV-infection.
  
  
  CONCLUSIONS
  Our results suggest that 25% of the haemophiliacs will develop AIDS eight years after seroconversion, and a decreasing incidence is not observed. Lower progression rate to AIDS in children than in adults is confirmed.
authors.affiliation: Unidad de Coagulopatías Congénitas de la Comunidad Valenciana.
authors.forename: J I
authors.initials: JI
authors.lastname: Lorenzo
authors.forename: R
authors.initials: R
authors.lastname: Molina
authors.forename: M L
authors.initials: ML
authors.lastname: Senent
authors.forename: E
authors.initials: E
authors.lastname: Monzó
authors.forename: M A
authors.initials: MA
authors.lastname: Lerma
authors.forename: M A
authors.initials: MA
authors.lastname: Dasí
authors.forename: E
authors.initials: E
authors.lastname: Monteagudo
authors.forename: J A
authors.initials: JA
authors.lastname: Aznar
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000453:epidemiology* / Q000401:mortality; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D016516:CD4-CD8 Ratio; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005500:Follow-Up Studies; D006679:HIV Seropositivity / Q000150:complications* / Q000188:drug therapy; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D015994:Incidence; D015993:Life Tables; D008297:Male; D009894:Opportunistic Infections / Q000150:complications / Q000453:epidemiology; D015215:Zidovudine / Q000627:therapeutic use
chemical_list: D015215:Zidovudine
vernacular_title: Progresión a SIDA en hemofílicos seropositivos frente al VIH.