Inhibitory effect of (4R)-hexahydro-7,7-dimethyl-6-oxo-1,2,5-dithiazocine-4-carboxylic acid (SA3443), a novel cyclic disulfide, on the production of TNF-like factor from Propionibacterium acnes-primed rat liver macrophages/Kupffer cells.
The effect of (4R)-hexahydro-7,7-dimethyl-6-oxo-1,2,5-dithiazocine-4-carboxylic acid (SA3443), a novel cyclic disulfide, on tumor necrosis factor (TNF)-like factor production from Propionibacterium acnes (P. acnes)-primed rat liver macrophages/Kupffer cells was investigated. A remarkable increase in TNF-like activity was detected in the culture supernatants of the liver macrophages/Kupffer cells from P. acnes-treated rats. At concentrations of 1 x 10(-6) to 1 x 10(-4) M, SA3443 significantly inhibited the production/release of TNF-like factor from these P. acnes-primed/activated liver macrophages/Kupffer cells.
Sasano
M
M
Central Research Laboratories, Santen Pharmaceutical Co., Ltd., Osaka, Japan.
Nakata
K
K
Mita
S
S
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001392:Azocines / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004220:Disulfides / Q000494:pharmacology*; D016908:Gram-Positive Bacterial Infections / Q000378:metabolism / Q000382:microbiology; D007728:Kupffer Cells / Q000187:drug effects / Q000378:metabolism* / Q000382:microbiology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008099:Liver / Q000166:cytology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism* / Q000382:microbiology; D008297:Male; D011425:Propionibacterium acnes; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000096:biosynthesis*
D000276:Adjuvants, Immunologic; D001392:Azocines; D004220:Disulfides; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; C069788:SA 3443