Changes in polymorphonuclear neutrophil-elastase in pancreatitis.
In cases of acute and chronic pancreatitis, we measured the amount of polymorphonuclear neutrophil (PMN)-elastase. There was a significantly larger increase in PMN-elastase in patients with pancreatitis than normal adults. Especially, there was a particularly notable increase in amount of PMN-elastase in patients with severe pancreatitis. Furthermore, the peak of PMN-elastase increase throughout the course of the pancreatitis was seen to be 1-2 days after peak increase in pancreatic enzymes. In the experiment in which pancreatic juice and pig pancreatic kallikrein were added to granulocytes in vitro, we recognized a gradual release of PMN-elastase. From these data, we suggested that timely measurements of PMN-elastase are useful to marker of monitoring clinical changes in severe pancreatitis.
Uehara
S
S
Department of Internal Medicine, Tonan Hospital, Sapporo, Japan.
Gotoh
K
K
Handa
H
H
Honjo
K
K
Hiraŷama
A
A
Sakamoto
W
W
D000208:Acute Disease; D000328:Adult; D000818:Animals; D002908:Chronic Disease; D006098:Granulocytes / Q000187:drug effects / Q000201:enzymology*; D006801:Humans; D066298:In Vitro Techniques; D007610:Kallikreins / Q000494:pharmacology; D019272:Leukocyte Elastase; D010196:Pancreatic Elastase / Q000097:blood*; D010189:Pancreatic Juice / Q000502:physiology; D010195:Pancreatitis / Q000097:blood / Q000201:enzymology* / Q000503:physiopathology; D012016:Reference Values; D013552:Swine
D007610:Kallikreins; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase