title: Omeprazole in the treatment of peptic ulcers and gastroesophageal reflux disease.
abstract: Omeprazole blocks the final step of gastric acid secretion by blocking the proton pump (the hydrogen and potassium ATPase) in gastric parietal cells. Due to this direct action, omeprazole is the most potent, clinically available suppressor of gastric acidity.
authors.affiliation: Department of Medicine/Gastroenterology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick 08903-0019.
authors.forename: M S
authors.initials: MS
authors.lastname: Cappell
mesh_terms: D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006801:Humans; D009853:Omeprazole / Q000494:pharmacology / Q000627:therapeutic use*; D010437:Peptic Ulcer / Q000188:drug therapy*
chemical_list: D009853:Omeprazole