Characterization of two human mammary carcinomas, MT-1 and MT-3, suitable for in vivo testing of ether lipids and their derivatives.
The human mammary carcinomas MT-1 and MT-3 originate from surgical material and were transplanted in nude mice. Both tumors have been classified as estradiol- and progesterone receptor-negative. Therapeutic doses of hormones and anti-hormones remained without growth inhibitory effect. MT-1 and MT-3 proved to be sensitive to conventional cytostatic drugs used for treatment of mammary carcinomas; striking is their sensitivity to ether lipids. Therefore, they are considered suitable tumor models for this class of substances.
Naundorf
H
H
Max-Delbrück Centrum for Molecular Medicine, Berlin-Buch, Germany.
Rewasowa
E C
EC
Fichtner
I
I
Büttner
B
B
Becker
M
M
Görlich
M
M
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology*; D002277:Carcinoma / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D010767:Phosphorylcholine / Q000008:administration & dosage / Q000031:analogs & derivatives; D011003:Ploidies; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D010767:Phosphorylcholine; C039128:miltefosine; C032164:n-octadecylphosphocholine