Absorption of wheat starch in patients resected for left-sided colonic cancer.
Bacterial fermentation of carbohydrate in the colon, producing short-chain fatty acids (SCFA)--and especially butyrate--has been shown possibly to impede cell proliferation and regulate cell differentiation of colonocytes. In patients with diverticular disease or benign polyps in the colon a hyperabsorption of potato starch in the small intestine has been found. We have investigated the absorption of wheat starch in 15 patients radically resected for cancer in the descending or sigmoid colon, and the results were compared with those of 15 healthy controls. The starch malabsorption was quantified by the hydrogen breath test. The patients malabsorbed 2-14 g (median, 8 g) of 100 g wheat starch ingested, and the control group malabsorbed 3-11 g (median, 6 g) (P greater than 0.1). Mouth-to-cecum transit time for wheat starch and lactulose and the hydrogen production capacity after the lactulose standards were also similar in patients and controls. The results do not support the theory that hyperabsorption of starch is characteristic of patients with malignant disease in the large intestine.
Nordgaard
I
I
Dept. of Gastroenterology and Internal Medicine F, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Rumessen
J J
JJ
Nielsen
S A
SA
Gudmand-Høyer
E
E
D000328:Adult; D000368:Aged; D003110:Colonic Neoplasms / Q000378:metabolism* / Q000601:surgery*; D004187:Disaccharides / Q000008:administration & dosage / Q000493:pharmacokinetics; D005260:Female; D005772:Gastrointestinal Transit / Q000502:physiology; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D013213:Starch / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014908:Triticum / Q000378:metabolism*
D004187:Disaccharides; D013213:Starch