A single vaccination with an inactivated hepatitis A liposome vaccine induces protective antibodies after only two weeks.
In the near future an inactivated hepatitis A vaccine will be commercially available. The recommended vaccination schedule will include at least two vaccinations 1 month apart. Giving two doses of vaccine on the same day in one injection results in protection after 2-4 weeks dependent on the adjuvant used. Hepatitis A virus incorporated into liposomes proved to be a suitable formulation in term of rapid seroconversion, high level of mean antibody content and low reactogenicity.
Just
M
M
University Children's Hospital, Basel, Switzerland.
Berger
R
R
Dreschsler
H
H
Brantschen
S
S
Glück
R
R
D000328:Adult; D005260:Female; D006506:Hepatitis A / Q000276:immunology / Q000517:prevention & control; D022362:Hepatitis A Vaccines; D006508:Hepatitis Antibodies / Q000096:biosynthesis*; D006801:Humans; D007115:Immunization Schedule; D007273:Injections, Intramuscular; D008081:Liposomes; D008297:Male; D014611:Vaccination; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*
D022362:Hepatitis A Vaccines; D006508:Hepatitis Antibodies; D008081:Liposomes; D015164:Vaccines, Inactivated; D014761:Viral Hepatitis Vaccines