title: Autocrine regulation of murine B lymphocyte growth by an IgM antibody.
abstract: Culture supernatants of LPS-stimulated murine B lymphocytes are able to inhibit the growth of freshly isolated splenic B cells via an IgM antibody. The binding specificity of this IgM is not yet defined, but appears to be a B lymphocyte surface structure distinct from membrane immunoglobulin, MHC class II antigen, transferrin and Fc gamma receptors, and B220. The regulatory autoantibody allows the normal progression of early, but not late steps in the cycle of polyclonally-stimulated B lymphocytes and does not affect the increased antigen-presenting capacity of activated B cells. Therefore, this autoregulatory cycle is apparently ubiquitous and may be a major component of B lymphocyte homeostasis under physiological, as well as pathological conditions. Moreover, these findings bring into focus a possible regulating role of B lymphocytes in the humoral immune response.
authors.affiliation: Department of Immunology, Lóránd Eötvös University, Göd, Hungary.
authors.forename: F
authors.initials: F
authors.lastname: Uher
authors.forename: M E
authors.initials: ME
authors.lastname: Alonso
authors.forename: R
authors.initials: R
authors.lastname: Mihalik
authors.forename: E
authors.initials: E
authors.lastname: Balogh
authors.forename: J
authors.initials: J
authors.lastname: Gergely
mesh_terms: D000818:Animals; D000918:Antibody Specificity; D001323:Autoantibodies / Q000737:chemistry / Q000502:physiology; D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology; D002455:Cell Division / Q000276:immunology; D006131:Growth Inhibitors / Q000276:immunology; D007108:Immune Tolerance; D007075:Immunoglobulin M / Q000737:chemistry / Q000502:physiology*; D008213:Lymphocyte Activation; D051379:Mice; D008811:Mice, Inbred DBA
chemical_list: D001323:Autoantibodies; D006131:Growth Inhibitors; D007075:Immunoglobulin M