title: [Frequency and risk factors associated with metronidazole therapeutic noncompliance].
abstract: OBJECTIVE
  to determine the frequency and risk factors of non-compliance to oral metronidazole.
  
  
  METHODS
  comparative cross-sectional survey.
  
  
  METHODS
  111 patients who received oral metronidazole. SETTING CHARACTERISTICS: two medical units: one primary level unit and one secondary care unit of the Mexican Institute of Social Security.
  
  
  METHODS
  non-compliance was assessed by home interview and pill count.
  
  
  RESULTS
  frequency of non-compliance was 55%. Risk factors for non-compliance were: female sex (OR = 3.0; p less than 0.05); side effects (OR = 3.1; p less than 0.05); low literacy (OR = 3.75; p less than 0.05). Stratified analysis showed no interaction between variables.
  
  
  CONCLUSIONS
  frequency of non-compliance to metronidazole is high, and could affect the effectiveness of medical care. Female patients with low literacy and who suffer side effects are a high risk group for non-compliance.
authors.affiliation: Unidad de Investigación Clínica en Enfermedades Infecciosas y Parasitarias, Hospital de Pediatría, Instituto Mexicano del Seguro Social, D.F.
authors.forename: J
authors.initials: J
authors.lastname: Garduño-Espinosa
authors.forename: M C
authors.initials: MC
authors.lastname: Martínez-García
authors.forename: A
authors.initials: A
authors.lastname: Fajardo-Gutiérrez
authors.forename: M
authors.initials: M
authors.lastname: Ortega-Alvarez
authors.forename: A
authors.initials: A
authors.lastname: Alvarez-Espinosa
authors.forename: V
authors.initials: V
authors.lastname: Vega-Pérez
authors.forename: O
authors.initials: O
authors.lastname: Muñoz-Hernández
mesh_terms: D000284:Administration, Oral; D000328:Adult; D003430:Cross-Sectional Studies; D004522:Educational Status; D005260:Female; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D010349:Patient Compliance; D012307:Risk Factors
chemical_list: D008795:Metronidazole
vernacular_title: Frecuencia y factores de riesgo asociados al incumplimiento terapéutico con metronidazol.