Interferon-alpha induced autoimmune hepatitis in a patient with Philadelphia chromosome-positive chronic myeloid leukemia with cytogenetically normal T lymphocytes.
We report the occurrence of autoimmune hepatitis after treatment with interferon-alpha in a patient with Philadelphia chromosome-positive chronic myeloid leukemia. Cytogenetic and molecular genetic studies of the T lymphocytes in this patient demonstrated that the T lymphocytes were not part of the leukemic clone. The role of interferon in the production of autoimmune abnormalities is reviewed.
Ariad
S
S
Department of Medicine, Johannesburg Hospital, University of the Witwatersrand, South Africa.
Song
E
E
Cohen
R
R
Bezwoda
W R
WR
D000328:Adult; D001327:Autoimmune Diseases / Q000209:etiology*; D005260:Female; D006505:Hepatitis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D013601:T-Lymphocytes / Q000648:ultrastructure*
D016898:Interferon-alpha