Effects of verapamil on histamine-induced changes in lung mechanics.
The effects of verapamil on airway resistance and total thoracic compliance were studied in 15 rabbits with histamine-induced changes in lung mechanics. The animals, after being tracheotomized under anaesthesia, were subjected to mechanical ventilation in a time-cycled, volume-limited mode. Airway pressure and gas flow signals measured by a pneumotachograph and integrated for volume, were registered on a recorder. Each animal was given histamine hydrochloride in an isotonic solution of sodium chloride at a rate of 0.05 micrograms.kg-1.min-1 through a peripheral venous line. Verapamil was infused intravenously in an isotonic solution of sodium chloride at a rate of 20 micrograms.kg-1.min-1 after the initiation of histamine. Verapamil reduced the histamine-induced increase in airway resistance by 20% at 20 min after the start of administration.
Mima
M
M
Department of Anaesthesia, Kansai Medical University, Moriguchi, Japan.
Taguchi
H
H
Oya
M
M
D000403:Airway Resistance / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology*; D007262:Infusions, Intravenous; D001239:Inhalation / Q000187:drug effects / Q000502:physiology; D008168:Lung / Q000187:drug effects* / Q000502:physiology; D008170:Lung Compliance / Q000187:drug effects* / Q000502:physiology; D008297:Male; D011817:Rabbits; D012121:Respiration, Artificial; D015656:Respiratory Mechanics / Q000187:drug effects* / Q000502:physiology; D013909:Thorax / Q000187:drug effects / Q000502:physiology; D013997:Time Factors; D014700:Verapamil / Q000008:administration & dosage / Q000494:pharmacology*
D006632:Histamine; D014700:Verapamil