title: [Disseminated fungal infections in neonates--risk factors, treatment and course].
abstract: During 10 1/2 months in 1990/91 eight premature babies and one mature baby with an intra-abdominal disease had disseminated Candida albicans infections. The incidence in premature newborns was 9% (8/92 patients). Risk factors such as respirator therapy, the use of broad spectrum antibiotics, supplemental parenteral nutrition and central intravascular catheters were frequently seen. Four patients survived the fungal infection. These included three of five babies treated with amphotericin B 0.5 mg/kg/day. Two patients who received fluconazole 3 mg/kg/day died after three days. In one patient the diagnosis was obtained post-mortem, and one patient with possible fungemia survived without therapy. The treatment of these patients depends on optimal fungal cultures and good co-operation between paediatricians and microbiologists.
authors.affiliation: Barneklinikken, Rikshospitalet, Oslo.
authors.forename: T G
authors.initials: TG
authors.lastname: Abrahamsen
authors.forename: P
authors.initials: P
authors.lastname: Gaustad
authors.forename: S
authors.initials: S
authors.lastname: Sund
authors.forename: T W
authors.initials: TW
authors.lastname: Hansen
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D002405:Catheterization, Central Venous / Q000009:adverse effects; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D008297:Male; D010288:Parenteral Nutrition / Q000009:adverse effects; D012138:Respiratory Therapy / Q000009:adverse effects; D012307:Risk Factors
chemical_list: D000900:Anti-Bacterial Agents
vernacular_title: Disseminerte soppinfeksjoner hos nyfødte--risikofaktorer, behandling og forløp.