Effects of peripheral hormones on memory and ingestive behaviors.
This article explores the mechanisms by which peripheral gastrointestinal hormones produce central nervous system effects on memory and feeding. Cholecystokinin produces its satiety effects and memory-enhancing effects by stimulating ascending vagal fibers. Hyperglycemia has been demonstrated to be a cause of memory dysfunction in persons with diabetes mellitus. A number of other hormones, such as amylin and bombesin, modulate both memory processing and feeding. The causes of the anorexia of aging are briefly reviewed.
Morley
J E
JE
Geriatric Research, Education, and Clinical Center, St. Louis Department of Veterans Affairs, Missouri.
Flood
J
J
Silver
A J
AJ
D000375:Aging / Q000502:physiology*; D000818:Animals; D000855:Anorexia / Q000503:physiopathology; D001066:Appetite / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000503:physiopathology*; D002766:Cholecystokinin / Q000502:physiology; D004435:Eating / Q000502:physiology*; D005768:Gastrointestinal Hormones / Q000502:physiology; D006728:Hormones / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000502:physiology; D008568:Memory / Q000502:physiology*; D009479:Neuropeptides / Q000502:physiology
D001786:Blood Glucose; D005768:Gastrointestinal Hormones; D006728:Hormones; D007328:Insulin; D009479:Neuropeptides; D002766:Cholecystokinin