title: Structure determination and toxicity of a new microcystin from Microcystis aeruginosa strain 205.
abstract: A new hepatotoxic microcystin was isolated from the cyanobacterium Microcystis aeruginosa strain 205. Its structure was found to be [Dha7]microcystin-RR as determined by amino acid analysis, mass spectrometry and 1H NMR spectroscopy. LD50 value (i.p. mouse) of this toxin was 180 micrograms/kg. The 48 hr lethal concentration (48-hr-LC50) of the toxin for larvae of the yellow fever mosquito, Aedes aegypti, was 14.9 micrograms/ml.
authors.affiliation: Department of Pharmacy, University of Helsinki, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Kiviranta
authors.forename: M
authors.initials: M
authors.lastname: Namikoshi
authors.forename: K
authors.initials: K
authors.lastname: Sivonen
authors.forename: W R
authors.initials: WR
authors.lastname: Evans
authors.forename: W W
authors.initials: WW
authors.lastname: Carmichael
authors.forename: K L
authors.initials: KL
authors.lastname: Rinehart
mesh_terms: D000330:Aedes; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000503:physiopathology; D002851:Chromatography, High Pressure Liquid; D007814:Larva; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D052998:Microcystins; D046931:Microcystis / Q000737:chemistry*; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000633:toxicity
chemical_list: C492352:((Dha)7)-microcystin-RR; D000596:Amino Acids; D052998:Microcystins; D010456:Peptides, Cyclic