Radiation-induced optic neuropathy: correlation of MR imaging and radiation dosimetry.
The authors performed topographic correlation of dosimetric measurements with contrast medium-enhanced magnetic resonance (MR) imaging signal aberration in two cases of radiation optic neuropathy. The region of pathologic contrast enhancement in the optic nerve and chiasm had received 55-62 Gy, which supports the theory that the risk of injury to the optic nerve and chiasm increases steeply with radiation doses above the tolerance level of 50-55 Gy.
Young
W C
WC
Department of Radiology, University of Michigan Medical School, Ann Arbor.
Thornton
A F
AF
Gebarski
S S
SS
Cornblath
W T
WT
D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009897:Optic Chiasm / Q000473:pathology / Q000528:radiation effects; D009900:Optic Nerve / Q000473:pathology / Q000528:radiation effects; D009901:Optic Nerve Diseases / Q000175:diagnosis* / Q000209:etiology*; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000175:diagnosis*; D011878:Radiotherapy / Q000009:adverse effects*