Hepatitis delta virus infection in Bombay.
From June 1985 to June 1989, sera from 425 cases of acute viral hepatitis were gathered from 2 hospitals in Bombay; 331 sera were positive for hepatitis B surface antigen and immunoglobulin M anti-hepatitis B core antigen, and the donors' disease was diagnosed as hepatitis B. Anti-hepatitis D virus was found in 124 of these sera, and hepatitis D antigen was present in 24 more, conclusively proving the presence of hepatitis delta infection in association with hepatitis B in Bombay. Among the 425 cases of hepatitis, 39 cases of fulminant hepatitis developed, of whom 31 died. Hepatitis B virus (HBV) was the apparent viral infection in 32 of the fulminant cases, and 20 (63%) of them also showed evidence of hepatitis D virus (HDV) infection, suggesting an aggravation of their clinical course due to concurrent HBV and HDV infections.
Banker
D D
DD
Sir Hurkisondas Nurrotumdas Medical Research Society, Bombay, India.
Desai
P
P
Brawner
T A
TA
Decker
R H
RH
D000328:Adult; D005260:Female; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D003699:Hepatitis D / Q000453:epidemiology / Q000209:etiology / Q000276:immunology*; D003698:Hepatitis Delta Virus / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007194:India / Q000453:epidemiology; D008297:Male
D006514:Hepatitis B Surface Antigens; D007075:Immunoglobulin M