[The prognosis of the outcome of the inflammatory process in chronic bronchitis].
The authors relate the data on the leading part fibrosoformation plays in the disease outcome in patients with certain pulmonary chronic illnesses. The levels of free and bound hydroxyproline and hyaluronidase activity served as diagnostic criteria for processes of fibrosoformation. Based on the data obtained a method of predicting chronic bronchitis (CB) was devised. Thus, the two-fold rise of hyaluronidase activity as compared to normal and the index of fibrosing (the ratio of free to bound hydroxyproline) exceeding 1 suggest an unfavourable course of CB accompanied by the enhancement of fibrosoformation. Meanwhile if hyaluronidase activity increases 2-fold and more and the index of fibrosing is less than 1, the prognosis of inflammatory process may be favourable. Based on the clinical data, the significance of prognosis was proved in 93% of cases.
Ubaĭdullaev
A M
AM
Liverko
I V
IV
Chernik
M B
MB
D001991:Bronchitis / Q000150:complications / Q000378:metabolism / Q000628:therapy*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D002908:Chronic Disease; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000032:analysis; D006909:Hydroxyproline / Q000032:analysis; D011379:Prognosis; D011658:Pulmonary Fibrosis / Q000209:etiology / Q000378:metabolism / Q000628:therapy; D016896:Treatment Outcome
D006821:Hyaluronoglucosaminidase; D006909:Hydroxyproline
Prognoz iskhoda vospalitel'nogo protsessa pri khronicheskom bronkhite.