title: A preliminary study on the interaction of cell-polymer extract towards biodegradation.
abstract: Two newly synthesised polyurethanes were subjected to a preliminary study, in-vitro, on the interaction of cell polymer extract to understand the phenomenon of biodegradation by employing VERO cells. VERO cells exposed to the saline extract of the polymer showed cytopathic effect with granulations in the digestive vacuoles. It is suggested that the long term material performance of an implant-material can be evaluated by using VERO cells and/or macrophages and by analysing metabolic products secreted by the cells during interaction.
authors.affiliation: Division of Technical Evaluation of Biomaterials, Sree Chitra Tirunal Institute of Medical Sciences and Technology, Trivandrum, Kerala, India.
authors.forename: M
authors.initials: M
authors.lastname: Jayabalan
authors.forename: M
authors.initials: M
authors.lastname: Raveendranath
authors.forename: J
authors.initials: J
authors.lastname: Shanmugam
mesh_terms: D000818:Animals; D001673:Biodegradation, Environmental; D004355:Drug Stability; D011140:Polyurethanes / Q000737:chemistry* / Q000378:metabolism; D012965:Sodium Chloride / Q000737:chemistry; D014709:Vero Cells / Q000378:metabolism
chemical_list: D011140:Polyurethanes; D012965:Sodium Chloride