[The dynamics of the concentration of atrial natriuretic factor depending on changes in the arterial pressure level in patients with arterial hypertension].
The purpose of the study was to explore the dynamics of the concentration of atrial natriuretic hormone (ANH) in response to changes in arterial pressure including those induced by hypertonic crisis, 7-day hypotensive monotherapy with the drugs having different action mode, and the acute test with the basic hypotensive drugs. 75 patients suffering from arterial hypertension were entered into the study. Measurements of the concentration of ANH in blood plasma were performed by radioimmunoassay with the aid of the kits manufactured by the Amersham Company (Great Britain). The activity of renin and aldosterone was determined by radioimmunoassay according to the standard technique. A strong positive correlation was revealed between the concentration of ANH and the level of both systolic and diastolic AP. A significant rise of the concentration of ANH elicited by hypertonic crisis reflects the growth of the tension of the depressor mechanisms by which AP is regulated. The lack of significant changes in the level of ANH during the acute pharmacological tests and effective continuous treatment with the hypotensive drugs attests to the existence of the complex mechanisms that regulate ANH secretion, determined not only by the level of AP.
Tomashets
E A
EA
Mazur
N A
NA
Masenko
V P
VP
D000450:Aldosterone / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000097:blood* / Q000187:drug effects; D001794:Blood Pressure / Q000502:physiology*; D002216:Captopril / Q000627:therapeutic use; D002908:Chronic Disease; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use; D012083:Renin / Q000097:blood / Q000187:drug effects
D006852:Hydrochlorothiazide; D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D002216:Captopril; D011433:Propranolol; D012083:Renin; D009543:Nifedipine
Dinamika kontsentratsii predserdnogo natriĭureticheskogo faktora v zavisimosti ot izmeneniĭ urovnia arterial'nogo davleniia u bol'nykh arterial'noĭ gipertonieĭ.