Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention.
Evidence from pathology and epidemiology studies has been provided for a human model of gastric carcinogenesis with the following sequential stages: chronic gastritis; atrophy; intestinal metaplasia; and dysplasia. The initial stages of gastritis and atrophy have been linked to excessive salt intake and infection with Helicobacter pylori. The intermediate stages have been associated with the ingestion of ascorbic acid and nitrate, determinants of intragastric nitrosation. The final stages have been linked with the supply of beta-carotene and with excessive salt intake. Nitrosating agents are candidate carcinogens and could originate in the gastric cavity or in the inflammatory infiltrate.
Correa
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Department of Pathology, Louisiana State University Medical Center, New Orleans 70112-1393.
D001205:Ascorbic Acid / Q000494:pharmacology; D002273:Carcinogens / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D016480:Helicobacter pylori / Q000472:pathogenicity; D006801:Humans; D012982:Sodium, Dietary / Q000009:adverse effects; D013274:Stomach Neoplasms / Q000209:etiology* / Q000517:prevention & control
D002273:Carcinogens; D012982:Sodium, Dietary; D001205:Ascorbic Acid