Pharmacokinetics of the oxime HI-6 from a mixture with atropine sulphate in dogs.
The pharmacokinetics of the oxime HI-6 from an aqueous solution and from a mixture containing HI-6 and atropine (in doses similar as proposed for their combination in an automatic injector) was studied in German shepherd dogs. A standard manual injection of mixed drugs was followed by enhanced resorption of HI-6 while the elimination curves were quite similar. A comparison of the parameters describing relative bioavailability at the 80% probability level did not reveal any significant differences between the formulations of HI-6. The increase in HI-6 level in blood of animals receiving a mixture is more likely to be attributed to the local vasodilatation than to the systemic cardiovascular effects of atropine.
Jovanović
D
D
Military Technical Institute, Medical Department, Belgrade, Yugoslavia.
Kovacević
V
V
Maksimović
M
M
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D001682:Biological Availability; D002801:Cholinesterase Reactivators / Q000097:blood / Q000493:pharmacokinetics*; D004285:Dogs; D004338:Drug Combinations; D005260:Female; D007273:Injections, Intramuscular; D008297:Male; D010091:Oximes; D011726:Pyridinium Compounds / Q000097:blood / Q000493:pharmacokinetics*
D002801:Cholinesterase Reactivators; D004338:Drug Combinations; D010091:Oximes; D011726:Pyridinium Compounds; D001285:Atropine; C022870:asoxime chloride