HTLV-related markers in a Hungarian patient with adult T-cell leukemia.
Monoclonal integration of DNA sequences related to, but not identical to HTLV-I provirus was detected in the peripheral blood lymphocytes of a Hungarian male suffering from ATL. The patient and his parents showed serological cross-reactivity with both HTLV-I and HTLV-II group-specific antigens. Restriction enzyme analysis with EcoRI, PstI, BamHI, HindIII and SacI revealed structural similarity of the provirus integrated in the DNA of ATL cells to HTLV-I but not to HTLV-II. Data suggest that this provirus and HTLV-I are similar to each other along gag and pol regions, but they are different in the env region.
Kiss
J
J
Institute of Microbiology, University Medical School of Debrecen, Hungary.
Telek
B
B
Tóth
F D
FD
Rejtö
L
L
Surányi
P
P
Rák
K
K
D000293:Adolescent; D000956:Antigens, Viral; D015139:Blotting, Southern; D003429:Cross Reactions; D004279:DNA, Viral / Q000032:analysis*; D005819:Genetic Markers; D015368:Human T-lymphotropic virus 1 / Q000235:genetics* / Q000276:immunology; D006801:Humans; D006814:Hungary; D015458:Leukemia, T-Cell / Q000382:microbiology*; D008297:Male
D000956:Antigens, Viral; D004279:DNA, Viral; D005819:Genetic Markers