title: Hageman factor dependent activation and its relationship to lethal Pseudomonas aeruginosa burn wound infections.
abstract: Trauma causes increases in total protease load in the circulation of the traumatized host animal or patient. This increase is due, in part, to Hageman Factor activation followed by down-line cascade system activation. Concomitant with the activation of these systems is a reduced host capacity to resist infection. Infection superimposed on a traumatized host increases the total host protease load even more by additional activation of Hageman Factor and cascade systems.
authors.affiliation: Department of Surgery, University of Cincinnati College of Medicine, Ohio.
authors.forename: I A
authors.initials: IA
authors.lastname: Holder
authors.forename: A N
authors.initials: AN
authors.lastname: Neely
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D001920:Bradykinin / Q000378:metabolism*; D002056:Burns / Q000097:blood / Q000150:complications*; D004195:Disease Models, Animal; D005174:Factor XII / Q000378:metabolism*; D006168:Guinea Pigs; D007610:Kallikreins / Q000378:metabolism*; D007704:Kininogens / Q000378:metabolism; D007705:Kinins / Q000502:physiology*; D008297:Male; D008954:Models, Biological; D011288:Prekallikrein / Q000378:metabolism; D011480:Protease Inhibitors / Q000494:pharmacology; D011552:Pseudomonas Infections / Q000097:blood* / Q000209:etiology; D011550:Pseudomonas aeruginosa; D014946:Wound Infection / Q000097:blood*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D007704:Kininogens; D007705:Kinins; D011480:Protease Inhibitors; D005174:Factor XII; D011288:Prekallikrein; D007610:Kallikreins; D001920:Bradykinin