title: Outcome of children with resistant and relapsed Hodgkin's disease.
abstract: During the period 1974-89, 169 children with Hodgkin's disease were treated in the Paediatric Oncology Units of the Royal Marsden and St Bartholomew's Hospitals. The overall actuarial survival for the whole group was 81% at 10 years. Thirty-five of the 169 children either did not achieve a complete remission or subsequently relapsed. The estimated actuarial survival from initial relapse or failure of primary treatment was 60% at 5 years and 45% at 10 years. Over half of the patients requiring salvage therapy had declared themselves within 2 years and only 3 relapses occurred more than 3 years from diagnosis. Very few patients remain disease free long term after failure of primary and initial salvage therapy. Patients relapsing within a year of diagnosis or not achieving a complete response to primary therapy and those with disseminated relapse had a poor response to salvage therapy. A significant subgroup of patients had prolonged survival despite multiple relapses. Neither initial histology nor stage affected survival from relapse although numbers in each subgroup were small.
authors.affiliation: Department of Paediatric Oncology, St Bartholomew's Hospital, West Smithfield, London, UK.
authors.forename: N D
authors.initials: ND
authors.lastname: James
authors.forename: J E
authors.initials: JE
authors.lastname: Kingston
authors.forename: P N
authors.initials: PN
authors.lastname: Plowman
authors.forename: S
authors.initials: S
authors.lastname: Meller
authors.forename: R
authors.initials: R
authors.lastname: Pinkerton
authors.forename: A
authors.initials: A
authors.lastname: Barrett
authors.forename: R
authors.initials: R
authors.lastname: Sandland
authors.forename: T J
authors.initials: TJ
authors.lastname: McElwain
authors.forename: J S
authors.initials: JS
authors.lastname: Malpas
mesh_terms: D000206:Actuarial Analysis; D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D005260:Female; D006689:Hodgkin Disease / Q000401:mortality / Q000628:therapy*; D006801:Humans; D008297:Male; D011379:Prognosis; D011879:Radiotherapy Dosage; D012008:Recurrence; D012074:Remission Induction; D016896:Treatment Outcome