title: [Effect of intravenous pirenzepine on hemodynamics and gastric juice volume as well as pH in surgical patients].
abstract: The effects of pirenzepine on blood pressure, heart rate and gastric juice volume as well as pH were evaluated and compared with those after atropine and cimetidine in 54 adult patients divided into five groups. Patients in Groups A, P, AP, AC and ACP received atropine, pirenzepine, atropine plus pirenzepine, atropine plus cimetidine, or atropine, cimetidine plus pirenzepine, respectively. Atropine 0.5 mg and cimetidine 200 mg were given intramuscularly 60 min before induction of anesthesia, and pirenzepine 10 mg was given intravenously 5 min before induction. Gastric juice was aspirated just after, 60 and 120 min after induction of anesthesia. Mean blood pressure and heart rate remained unchanged following intravenous pirenzepine in Group P, whereas heart rate increased significantly in Groups AP and ACP. There were no significant differences in mean volume and pH of gastric juice among the groups just after and 120 min after induction of anesthesia, although gastric volume in Group AC was significantly less than in Groups P, AP and ACP 60 min after induction. Gastric pH increased gradually and gastric volume decreased slightly following intravenous pirenzepine. The incidence of samples with a pH higher than 2.5 was greater in Group AC than in Group P just after and 60 min after induction, whereas there was no difference between the two groups after 120 min. We conclude that intravenous pirenzepine 10 mg is effective to reduce gastric juice volume and acidity, and it should be given at least 60 min before induction of anesthesia.
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, Osaka City University Medical School.
authors.forename: Y
authors.initials: Y
authors.lastname: Oda
authors.forename: H
authors.initials: H
authors.lastname: Yukioka
authors.forename: M
authors.initials: M
authors.lastname: Fujimori
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D005750:Gastric Juice / Q000187:drug effects* / Q000378:metabolism; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010890:Pirenzepine / Q000494:pharmacology*; D013514:Surgical Procedures, Operative
chemical_list: D010890:Pirenzepine