[Two cases of pulmonary metastasis of colorectal cancer successfully treated with oral 5'-DFUR].
Two patients with pulmonary metastasis of colorectal cancer, who had previously undergone radical resection of primary tumor, were orally administered 5'-DFUR at 1,200 mg per day. Complete responses were obtained in both. The duration of response was 42 and 13 weeks, respectively. Some side effects such as diarrhea and aguesia were found in each patient, but the treatment could be continued after temporary suspension for a while or by decreasing the dosage. We concluded that pulmonary metastasis of colorectal cancer can respond remarkably to oral administration of 5'-DFUR at 1,200 mg per day, if the tumor cells have sensitivity to this drug.
Kato
M
M
First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Sawai
K
K
Noguchi
A
A
Minato
H
H
Takahashi
T
T
D000230:Adenocarcinoma / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D000284:Administration, Oral; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D005467:Floxuridine / Q000008:administration & dosage*; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000473:pathology* / Q000601:surgery; D012074:Remission Induction; D012811:Sigmoid Neoplasms / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed
D000970:Antineoplastic Agents; D005467:Floxuridine; C025034:doxifluridine