Specific cutaneous lesions in a CD8+ peripheral T-cell lymphoma.
Histopathologic, immunohistochemical, and ultrastructural studies were carried out on cutaneous lesions of a 43-year-old man with an aggressive peripheral T-cell lymphoma involving the lung, central nervous system, bone marrow, and skin. Some results are distinctive and not previously reported, such as extremely strong epidermotropism, aberrant CD8+ immunophenotype with lack of one pan T antigen (CD5), and giant cytoplasmic granules. We discuss these features comparing them with other hematologic malignancies usually involving the skin, such as cutaneous T-cell lymphoma, adult T-cell leukemia/lymphoma, angiocentric lymphomas, and malignant histiocytosis.
Marti
R M
RM
Department of Dermatology, Hospital Clinic i Provincial, Universidad de Barcelona, Spain.
Estrach
T
T
Palou
J
J
Urbano-Ispizua
A
A
Gratacos
J
J
Cervera
R
R
Feliu
E
E
Grau
J M
JM
Mascaro
J M
JM
D000328:Adult; D001706:Biopsy; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D016411:Lymphoma, T-Cell, Peripheral / Q000150:complications / Q000276:immunology / Q000473:pathology*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000276:immunology / Q000473:pathology*; D012867:Skin / Q000473:pathology*; D012878:Skin Neoplasms / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology