Mapping of the structural gene for S-adenosyl homocysteine hydrolase to mouse chromosome 2, and related sequences to chromosomes 8 and X.
Comparative mapping studies in human and mouse have shown that, to date, human Chromosome (Chr) 20 is completely syntenic with distal mouse Chr 2. The structural locus for S-adenosyl-L-homocysteine hydrolase (EC 3.3.1.1) in human, AHCY, maps to 20 qter-->q13.1, and we report here that the homologous locus in the mouse, Ahcy, maps to distal mouse Chr 2 with gene order Pcna-Ahcy-Ada. Analysis of 123 progeny of an interspecific backcross between a laboratory stock, AN, and Mus spretus using a rat cDNA probe revealed the presence of at least two other Ahcy-related sequences segregating independently in the mouse genome. One, Ahcy-rs1, was mapped to Chr 8 in the BXH recombinant inbred strains, and the other, Ahcy-rs2, shows a pattern of inheritance consistent with X-linkage.
Pilz
A
A
Department of Genetics and Biometry, University College London, UK.
Le Tissier
P
P
Moseley
H
H
Peters
J
J
Abbott
C
C
D000243:Adenosine Deaminase / Q000235:genetics; D043383:Adenosylhomocysteinase; D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004247:DNA; D015342:DNA Probes; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D006867:Hydrolases / Q000235:genetics*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D014960:X Chromosome
D015342:DNA Probes; D004247:DNA; D006867:Hydrolases; D043383:Adenosylhomocysteinase; D000243:Adenosine Deaminase