title: [Effect of interferon and interferon combined with 3-methylcholanthrene on the mixed function oxidase system in the liver of mice].
abstract: The authors have studied the effect of human interferon alpha alone, as well as its effect when co-administered with 3-methylcholanthrene, on the mixed function oxidase system (MFO) of mouse liver. The single interferon alpha treatment did not influence the activities of MFO. However it decreased significantly the enzyme-inducing effect of 3-methylcholanthrene during combined treatment.
authors.affiliation: Apáthy István Gyermekkórház-Rendelöintézet, Budapest.
authors.forename: I
authors.initials: I
authors.lastname: Szabó
authors.forename: K
authors.initials: K
authors.lastname: Róna
authors.forename: G
authors.initials: G
authors.lastname: Renczes
mesh_terms: D000818:Animals; D004347:Drug Interactions; D004790:Enzyme Induction / Q000187:drug effects; D016898:Interferon-alpha / Q000494:pharmacology*; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D008862:Microsomes, Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000187:drug effects*
chemical_list: D016898:Interferon-alpha; D008748:Methylcholanthrene; D006899:Mixed Function Oxygenases
vernacular_title: Interferon és interferon + 3-metilkolantrén együttes adásának hatása az egérmáj vegyestípusú oxidáz rendszerére.