[Anti-inflammatory and antipyretic activity of aqua-dihydroxybenzoate copper complexes].
Using screening methods, the anti-inflammatory and antipyretic activities of mononuclear otahedral complexes [composition:Cu(2,YDHB)2.H2O;dihydroxybenzoate ion - DHB; Y(n)-4(8).5(4) and 6(8)] and the corresponding carboxylic acids were studied. On paw dextran edema (rats, an effective dose of 10 mg/kg), a higher efficacy of the complexes was found as compared with the acids. All compounds significantly reduced the endotoxin pyretic reaction (rabbits, in a single dose of 20 mg/kg; in the case of the first two complexes half-dose was administered). Marked toxic effects were determined for Cu(II) salts when they were administered i.p. The observed biological activities of complexes are discussed in relation to their proposed structures.
Sokolík
J
J
Katedra anorganickej a organickej chémie a Katedra a toxikológie Farmaceutickej fakulty Univerzity Komenského.
Tumová
I
I
LucanskáB
Hecková
Z
Z
Krätsmár-Smogrovic
J
J
Svec
P
P
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use / Q000633:toxicity; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use / Q000633:toxicity; D003300:Copper; D062385:Hydroxybenzoates / Q000627:therapeutic use / Q000633:toxicity; D009942:Organometallic Compounds / Q000627:therapeutic use / Q000633:toxicity; D051381:Rats
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D062385:Hydroxybenzoates; D009942:Organometallic Compounds; D003300:Copper
Protzápalová a antipyretická aktivita akva-dihydroxybenzoátomednatých complexov.