title: MR imaging of skeletal metastases from medulloblastoma.
abstract: The findings of MR imaging in 3 patients with bone metastases from medulloblastoma are reported. The first patient showed focal lesions of low signal intensity on T1-weighted spin echo images at a time when bone scintigraphy was negative for metastases. This patient later developed extensive osteosclerotic lesions visible on plain films. The bone marrow of the second patient showed diffuse low signal intensity on T1-weighted images. After chemotherapy the signal intensity of the bone marrow increased which correlated with a return of normal hematopoietic tissue. A response to chemotherapy was also found on MR imaging and repeat bone marrow biopsies in a third patient. A consistent finding was a low signal intensity on pre-gadolinium images, but the pattern (focal or diffuse abnormal signal intensity) was different in each patient. To our knowledge, this is the first report on MR imaging findings in bone metastases from medulloblastoma.
authors.affiliation: Department of Diagnostic Radiology, Free University Hospital, Amsterdam, The Netherlands.
authors.forename: P R
authors.initials: PR
authors.lastname: Algra
authors.forename: T
authors.initials: T
authors.lastname: Postma
authors.forename: C J
authors.initials: CJ
authors.lastname: Van Groeningen
authors.forename: P
authors.initials: P
authors.lastname: Van der Valk
authors.forename: J L
authors.initials: JL
authors.lastname: Bloem
authors.forename: J
authors.initials: J
authors.lastname: Valk
mesh_terms: D000077:Acetabulum / Q000473:pathology; D000293:Adolescent; D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary*; D002528:Cerebellar Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D007085:Ilium / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008527:Medulloblastoma / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary*; D010384:Pelvic Bones / Q000473:pathology; D012888:Skull Neoplasms / Q000175:diagnosis / Q000556:secondary; D013125:Spinal Neoplasms / Q000175:diagnosis / Q000556:secondary