Predictors for live birth after unexplained spontaneous abortions: correlations between immunologic test results, obstetric histories, and outcome of next pregnancy without treatment.
Our objective was to determine whether results from tests for maternal serum antinuclear antibodies, cytotoxic antibodies to paternal lymphocytes, parental histocompatibility types, and blocking factors for maternal-paternal mixed lymphocyte reactions were predictive of pregnancy outcome without immunologic treatment. Pregnancy outcome data from 95 women with a history of unexplained recurrent spontaneous abortions who underwent immunologic tests at Jefferson Medical College were evaluated with multiple logistic regression analyses. The number of prior spontaneous abortions, history of another relevant diagnosis, parental sharing of one histocompatibility antigen, and maternal age were related to the outcome of the next pregnancy in women given no immunologic treatment (p = 0.05). No significant correlation was found between results from the immunologic tests or other history characteristics evaluated and outcome of the next pregnancy. The immunologic tests evaluated were not clinically useful predictors of pregnancy outcome.
Cowchock
F S
FS
Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania.
Smith
J B
JB
D000026:Abortion, Habitual / Q000175:diagnosis / Q000276:immunology; D000022:Abortion, Spontaneous / Q000175:diagnosis* / Q000276:immunology; D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D000961:Antilymphocyte Serum / Q000032:analysis; D005260:Female; D005328:Fetal Viability; D006680:HLA Antigens / Q000032:analysis; D006650:Histocompatibility Testing; D006801:Humans; D016015:Logistic Models; D007959:Lymphocyte Culture Test, Mixed; D008487:Medical History Taking; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D011379:Prognosis
D000974:Antibodies, Antinuclear; D000951:Antigens, Neoplasm; D000961:Antilymphocyte Serum; D006680:HLA Antigens; C020163:blocking factor