Morning vs evening effects of intrapulmonary administration of heparin in healthy men.
Calcium heparin in a dose of 13,200-15,300 U was administered in 8 healthy men, aged 26-54, by inhalation at 8:00 or 20:00, where each study was separated by a minimum of three weeks interval. Serum coagulation variables, lipids, electrolytes and enzymes were measured before inhalation, 2 h later and after 48 h. Following heparin inhalation changes both in coagulation variables and less distinct in lipids variables were noted at both test times, but no morning-evening differences were observed, with the exception of cholesterol and HDL.
Markiewicz
A
A
District Railway Hospital, Katowice, Poland.
Tausz
B
B
Zahorska-Markiewicz
B
B
Nawrot
J
J
D000280:Administration, Inhalation; D001777:Blood Coagulation / Q000187:drug effects; D002940:Circadian Rhythm; D004334:Drug Administration Schedule; D006493:Heparin / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male
D008055:Lipids; D006493:Heparin