title: Cerebellar manifestations of prostatic carcinoma.
abstract: We present two patients known to have prostate cancer who presented with acute cerebellar signs. The neurological deficit of the first patient was due to a paraneoplastic cerebellar manifestation and progressed, despite evidence of response of the primary prostate tumour to hormonal manipulation. The second case, resulting from a solitary cerebellar metastasis, was amenable to surgical intervention and subsequent hormonal manipulation. This latter patient has experienced no recurrent neurological signs after a period of 7 years follow-up. This is the first report of a paraneoplastic cerebellar deficit and, to our knowledge, only the sixth case of parenchymatous cerebellar metastasis of prostatic origin to appear in the literature.
authors.affiliation: Department of Urology, Southmead Hospital Westbury-on-Trym, Bristol, UK.
authors.forename: J
authors.initials: J
authors.lastname: McLoughlin
authors.forename: J C
authors.initials: JC
authors.lastname: Gingell
authors.forename: G
authors.initials: G
authors.lastname: Harper
authors.forename: A
authors.initials: A
authors.lastname: Hinchliffe
mesh_terms: D000208:Acute Disease; D000368:Aged; D002526:Cerebellar Diseases / Q000209:etiology*; D002528:Cerebellar Neoplasms / Q000556:secondary*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010257:Paraneoplastic Syndromes / Q000209:etiology*; D011471:Prostatic Neoplasms / Q000150:complications* / Q000473:pathology