[A comparative evaluation of combined immunocorrective therapy in rheumatoid arthritis with systemic manifestations (joint Soviet-Polish research)].
Thirty-two patients with rheumatoid arthritis were included in the trial. Each of them was assigned to one of the 4 groups comparable by the main features. Each group entered 8 patients. Group 1 patients underwent hemosorption weekly for 3 weeks. After the second procedure cyclophosphamide was added at a single IV dose 1000 mg. After the third procedure the treatment was continued with methotrexate (7.5 mg, weekly). Group 2 began the treatment with methotrexate (7.5 mg, weekly). Group 3 received cyclophosphamide 200 mg IV twice a week 6 times and then 200 mg weekly orally till a total dose of 2 g. Group 4 received azathioprine in a daily dose 100 mg. The treatment with nonsteroidal antirheumatic drugs and corticosteroids was continued unchanged. After 6 months we did not see significant differences between the 4 groups.
Oliunin
Iu A
IuA
Solov'ev
S K
SK
Balabanova
R M
RM
Chiklikchi
A S
AS
Filipowicz-Sosnowska
A
A
Garwolińska
H
H
Stanisławska
E
E
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000276:immunology / Q000628:therapy*; D001379:Azathioprine / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D006464:Hemoperfusion; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D011044:Poland; D014586:USSR
D003520:Cyclophosphamide; D001379:Azathioprine; D008727:Methotrexate
Sravnitel'naia otsenka kompleksnoĭ immunokorrigiruiushcheĭ terapii revmatoidnogo artrita s sistemnymi proiavleniiami (sovmestnoe sovetsko-pol'skoe issledovanie).