Influence of VIP on the number of enterochromaffin and mucosal mast cells in the colon of the rat.
The possibility that VIP (Vasoactive intestinal peptide) could influence the enterochromaffin (EC) cell secretion of serotonin (5HT) and the action of VIP on the mast cell population of lamina propria were investigated in Wistar rat colon infused with a short chain fatty acid solution (sodium acetate), during a 1 h period. Under the action of an intravenous injection of synthetic porcine VIP, 14 micrograms/kg/h), the number of EC cells diminished significantly in the cecum and left colon, when compared to non-injected animals, both infused with a sodium acetate solution. At the same time, the number of mucosal mast cells in the crypts and lamina propria decreased significantly in the cecum. The postulate we put forward is that these VIP-induced changes are exerted through the stimulation of 5HT released from EC cells not only under normal physiological conditions but probably also under pathological conditions.
Ledesma de Paolo
M I
MI
Instituto de Gastroenterologia Dr. Jorge Perez Companc, Buenos Aires, Argentina.
Celener Gravelle
F P
FP
Celener
D
D
Gonzalez
E
E
Rosembeck
G
G
Bandi
J C
JC
Fernandez
L B
LB
D000818:Animals; D002432:Cecum / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D002452:Cell Count; D003106:Colon / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D004759:Enterochromaffin Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D007413:Intestinal Mucosa / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008407:Mast Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
D012701:Serotonin; D014660:Vasoactive Intestinal Peptide