The pathogenetic aspects of spondyloarthropathies from the point of view of HLA-B27.
The association of HLA-B27 and seronegative spondyloarthropathies, especially ankylosing spondylitis has been known for almost two decades. The spontaneous development of spondyloarthropathy like joint disease in HLA-B27 transgenic rats verifies the suspicion that the HLA-B27 antigens are directly responsible for disease development. With the recently revealed crystal structure of HLA-B27 and understanding of the class I molecule in general, a new hypothesis can be formulated based on the assumption that the pathogenesis of these diseases is a subversion of the physiological function.
Kellner
H
H
Rheumatology Division, University of California, Los Angeles 90024-1670.
Yu
D
D
D000595:Amino Acid Sequence; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D015796:HLA-B27 Antigen / Q000032:analysis / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007592:Joint Diseases / Q000276:immunology*; D008969:Molecular Sequence Data
D015796:HLA-B27 Antigen