Clearance of indomethacin occurs predominantly by renal glucuronidation.
In this report we describe the conditions of collection, storage and handling of urine samples, collected after oral dosing with indomethacin in man, in order to maintain the integrity of the labile glucuronide formed. We found that the body clearance occurs predominantly by renal metabolism, due to glucuronidation in the human kidney. These glucuronides may be converted to isomeric glucuronides and/or the parent compound indomethacin during the residence time in the bladder.
Moolenaar
F
F
Department of Pharmacology and Therapeutics, University Centre for Pharmacy, Groningen, The Netherlands.
Crancrinus
S
S
Visser
J
J
De Zeeuw
D
D
Meijer
D K
DK
D000328:Adult; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D005965:Glucuronates / Q000378:metabolism* / Q000493:pharmacokinetics; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007213:Indomethacin / Q000493:pharmacokinetics* / Q000652:urine; D007668:Kidney / Q000378:metabolism*; D008297:Male; D013696:Temperature
D005965:Glucuronates; D007213:Indomethacin