title: [Effects of high-dose fentanyl anesthesia on auditory brain stem responses].
abstract: It was previously reported that high-dose (50 micrograms.kg-1) fentanyl anesthesia had no effect on auditory brainstem response (ABR). However, the effect of the dose of 100 micrograms.kg-1 of fentanyl is unknown. We examined the effects of the dose of 50 micrograms.kg-1 and 100 micrograms.kg-1 of fentanyl on ABRs in 10 patients scheduled for cardiovascular surgery. No significant change was observed immediately after infusion of 50 micrograms.kg-1 of fentanyl, but peak latencies of waves I, III and V were significantly prolonged and the amplitude of wave V was significantly decreased immediately after infusion of 100 micrograms.kg-1 of fentanyl. The interpeak latencies of I-III and I-V were not affected. Therefore, prolongations of latencies of waves III and V were due to the change of latency of wave I. These results demonstrate that high-dose (100 micrograms.kg-1) fentanyl anesthesia depresses the peripheral auditory perception but dose not depress the central conduction.
authors.affiliation: Department of Anesthesiology, Miyazaki Medical College.
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: H
authors.initials: H
authors.lastname: Kawasaki
authors.forename: S
authors.initials: S
authors.lastname: Shiraishi
authors.forename: M
authors.initials: M
authors.lastname: Takasaki
mesh_terms: D000328:Adult; D000368:Aged; D000771:Anesthesia, Intravenous; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects*; D005260:Female; D005283:Fentanyl / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D005283:Fentanyl