title: [Postvaccinal reactions to simultaneous administration of the triple viral, oral polio and diphtheria-tetanus vaccines compared with their administration in sequence].
abstract: OBJECTIVE
  To compare the frequency and characteristics of post-vaccination reactions, between on the one hand the simultaneous administration of the Oral Antipolio (OP), the Triple Virus (TV) and the Anti-Diphtheria and Anti-Tetanus (DT) vaccines; and on the other hand, their administration in sequence.
  
  
  METHODS
  Prospective study with interventions, with a non-random, non-blind determination. SITE. Survey covering the mothers of infants vaccinated at 24 vaccination centres in Mála province.
  
  
  METHODS
  490 infants vaccinated during their second year of life. 263 had the vaccines administered simultaneously and 227 in sequence.
  
  
  METHODS
  Simultaneous administration of the TV, OP and DT vaccines at 15 months; as against the administration of TV at 15 months, followed by OP and DT at 18 months.
  
  
  RESULTS
  78 infants (29.66%) suffered a reaction that could be attributed to the vaccination after the simultaneous administration of TV, OP and DT; and 86 infants (37.88%) after one of the two occasions of vaccination in the administration in sequence: 27.31% after the TV, 17.18% after the OP-DT and 6.62% after both.
  
  
  CONCLUSIONS
  The safety of simultaneous administration, taken together with data coming from other studies on its immunogenic effectiveness, reaffirms the usefulness of simultaneous administration of TV, OP and DT vaccines at 15 months, as a strategy to improve vaccine coverage of infants in their second year of life.
authors.affiliation: Gerencia Provincial del Servicio Andaluz de Salud, Málaga.
authors.forename: A
authors.initials: A
authors.lastname: Jiménez Puente
authors.forename: P
authors.initials: P
authors.lastname: Cejas Hermoso
authors.forename: J D
authors.initials: JD
authors.lastname: Luna del Castillo
authors.forename: L M
authors.initials: LM
authors.lastname: Valles Casado
authors.forename: S
authors.initials: S
authors.lastname: Benítez Bocanegra
authors.forename: C
authors.initials: C
authors.lastname: Cortés Martínez
authors.forename: R
authors.initials: R
authors.lastname: Fernández Echegaray
authors.forename: B
authors.initials: B
authors.lastname: Fernández Navarro
authors.forename: Y
authors.initials: Y
authors.lastname: González Pérez
authors.forename: E
authors.initials: E
authors.lastname: Moreno Sánchez
mesh_terms: D000367:Age Factors; D004168:Diphtheria Toxoid / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007223:Infant; D011055:Poliovirus Vaccine, Oral / Q000008:administration & dosage* / Q000009:adverse effects; D013745:Tetanus Toxoid / Q000008:administration & dosage* / Q000009:adverse effects; D013997:Time Factors
chemical_list: D004168:Diphtheria Toxoid; D011055:Poliovirus Vaccine, Oral; D013745:Tetanus Toxoid
vernacular_title: Reacciones posvacunales tras la administración simultánea de vacunas triple vírica y antipolio oral-difteria-tétanos, frente a su administración secuencial.