title: Urinary collagen crosslinks reflect the radiographic severity of knee osteoarthritis.
abstract: The collagen crosslinks deoxypyridinoline and pyridinoline are indices of mature collagen breakdown and reflect increased bone turnover. Urinary levels were found to be significantly raised in a group of 59 women with knee OA compared to 110 female controls from the general population. Levels of the crosslinks correlated significantly with X-ray grade of all subjects including women from the general population with mild, often asymptomatic, disease. These correlations were not diminished after adjustment for age and weight.
authors.affiliation: Bone and Joint Research Unit, Medical College, Royal London Hospital.
authors.forename: P W
authors.initials: PW
authors.lastname: Thompson
authors.forename: T D
authors.initials: TD
authors.lastname: Spector
authors.forename: I T
authors.initials: IT
authors.lastname: James
authors.forename: E
authors.initials: E
authors.lastname: Henderson
authors.forename: D J
authors.initials: DJ
authors.lastname: Hart
mesh_terms: D000368:Aged; D000596:Amino Acids / Q000652:urine*; D003094:Collagen / Q000378:metabolism*; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging*; D008875:Middle Aged; D010003:Osteoarthritis / Q000000981:diagnostic imaging / Q000378:metabolism / Q000652:urine*; D011859:Radiography
chemical_list: D000596:Amino Acids; C015484:pyridinoline; C036020:deoxypyridinoline; D003094:Collagen