Immunological and gadolinium-DTPA MRI evaluation of relapsing remitting multiple sclerosis.
The levels of lymphocytes, blood lymphocytes subsets (CD3+, CD4+, CD8+, DR+, CD25+, CD4+, CD45RA+, CD4+, CD29+ cells) and sIL-2r of 10 patients affected by relapsing-remitting multiple sclerosis were serially studied. The identification of the activity of the disease was made by gadolinium-DTPA (Gd-DTPA) MRI. The immunological determinations and the MRI of the brain and spinal cord were performed every 14th day for a period of three months. No significant difference of the immunological values were found between the presence and the absence of Gd-DTPA enhancing areas, except lymphocytes (p < 0.05). These immunological parameters, evaluated in the peripheral blood, are not a marker of disease activity in relapsing-remitting MS patients.
Capra
R
R
Department of Neurology, University of Brescia, Italy.
Marcianó
N
N
Cotti Cometti
V
V
Vignolo
L A
LA
Bettinzioli
M
M
Airó
P
P
Cattaneo
R
R
Gasparotti
R
R
Moretti
R
R
D000328:Adult; D001812:Blood-Brain Barrier; D016516:CD4-CD8 Ratio; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000276:immunology; D016131:Lymphocyte Subsets / Q000276:immunology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000276:immunology; D009942:Organometallic Compounds; D004369:Pentetic Acid; D015375:Receptors, Interleukin-2 / Q000276:immunology*
D003287:Contrast Media; D009942:Organometallic Compounds; D015375:Receptors, Interleukin-2; D004369:Pentetic Acid; D019786:Gadolinium DTPA