title: [Physiopathologic and therapeutic aspects of persistent fetal circulation. Review of the literature and personal histological observations].
abstract: Persistence of the fetal circulation (PFC) is a syndrome characterized by failure of the cardiocirculatory system to adapt successfully to postnatal life. Its typical feature is persisting right-left shunt across fetal channels which determines cyanosis refractory to oxygen treatment. PFC can simulate cyanotic congenital cardiopathy. It has two forms: a primitive form and secondary one due to various causes especially perinatal asphyxia. Both forms have a common pathogenesis consisting of hypertension of the pulmonary arterial circulation. This article reviews the physiology of the main prenatal and postnatal circulatory characteristics and the factors which regulate the pulmonary circulation. It also reports the latest findings on PFC physiopathology and treatment indicating the prognostic factors and future perspectives.
authors.affiliation: Cattedra di Neonatologia, Università di Catania, Italia.
authors.forename: G
authors.initials: G
authors.lastname: Distefano
authors.forename: M G
authors.initials: MG
authors.lastname: Romeo
authors.forename: M G
authors.initials: MG
authors.lastname: Parisi
authors.forename: G
authors.initials: G
authors.lastname: Magro
mesh_terms: D001160:Arterioles / Q000473:pathology; D004280:Dobutamine / Q000627:therapeutic use; D004298:Dopamine / Q000627:therapeutic use; D004562:Electrocardiography; D006801:Humans; D006985:Hyperventilation / Q000503:physiopathology; D007231:Infant, Newborn; D008168:Lung / Q000098:blood supply / Q000473:pathology; D010102:Oxygen Inhalation Therapy; D010547:Persistent Fetal Circulation Syndrome / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D011379:Prognosis; D011652:Pulmonary Circulation; D014043:Tolazoline / Q000627:therapeutic use
chemical_list: D004280:Dobutamine; D014043:Tolazoline; D004298:Dopamine
vernacular_title: Aspetti fisiopatologici e terapeutici della persistenza della circolazione fetale. Revisione della letteratura ed osservazioni istologiche personali.