Bupropion and alcohol fatal intoxication: case report.
A fatality due to the ingestion of bupropion and ethanol is presented. Bupropion and its metabolites were extracted from several tissues and identified using gas chromatography with nitrogenphosphorus and mass spectrometry detection. The concentrations of bupropion, hydroxybupropion and the erythroamino and threoamino alcohol metabolites in heart blood were 4.2, 5.0, 0.6 and 4.6 mg/l, respectively. The heart blood ethanol concentration was 0.27 g/dl. In addition, bupropion was distributed as follows: subclavian blood, 6.2 mg/l; bile, 1.4 mg/l; kidney, 2.4 mg/l; liver, 1.0 mg/kg; stomach contents, 16 mg and urine, 37 mg/l.
Ramcharitar
V
V
Office of the Chief Medical Examiner, State of Maryland, Baltimore 21201.
Levine
B S
BS
Goldberger
B A
BA
Caplan
Y H
YH
D000328:Adult; D016642:Bupropion / Q000378:metabolism / Q000633:toxicity* / Q000652:urine; D000431:Ethanol / Q000097:blood / Q000633:toxicity*; D005260:Female; D006801:Humans; D013405:Suicide
D016642:Bupropion; D000431:Ethanol