title: Antiprogestin drugs: research and clinical use in Sweden.
abstract: The Swedish experience indicates that the combination of RU 486 and vaginal or intramuscular administration of different prostaglandin analogues such as Cervagem, Sulprostone, and 15- methyl PGF2 alpha is a highly effective and safe non-surgical method to terminate early pregnancy. The combined treatment may also be used during the second trimester. In mid- and late second trimester abortion this procedure represents a simple, non-invasive, highly effective method. There are several possibilities by which RU 486 can be used as a contraceptive. We have shown that post-ovulatory administration of RU 486 will effectively inhibit implantation. If the preliminary results are confirmed, treatment with RU 486 once a month on day LH+2 may be an attractive alternative to present contraceptive technology.
authors.forename: M
authors.initials: M
authors.lastname: Bygdeman
authors.forename: M L
authors.initials: ML
authors.lastname: Swahn
mesh_terms: D000021:Abortifacient Agents, Steroidal; D002260:Carboprost / Q000008:administration & dosage; D003280:Contraceptives, Oral, Synthetic; D004357:Drug Synergism; D005260:Female; D006801:Humans; D015735:Mifepristone / Q000008:administration & dosage*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011459:Prostaglandins E, Synthetic / Q000008:administration & dosage*; D018570:Risk Assessment; D013548:Sweden
chemical_list: D000021:Abortifacient Agents, Steroidal; D003280:Contraceptives, Oral, Synthetic; D011459:Prostaglandins E, Synthetic; D015735:Mifepristone; D002260:Carboprost