[Physicochemical and functional properties of hemoglobin of mice infected with Ehrlich's carcinoma].
Injection of white mice with Ehrlich's carcinoma triggers an increase in the mice blood erythrocyte fraction suspended in the 14% sucrose concentration zone. As established by acid erythrograms, a quantitative increase of this red blood cell population is due to an increased rate of erythroblast maturation and occurrence of immature cell forms in the blood stream. As shown by alkali denaturation of hemoglobin, tumour development causes an increase in alkali-resistant hemoglobin fraction in the erythrocytes. On the basis of the data on alkali denaturation of hemoglobin, it is suggested that in the infected mice increased rate of erythrocyte maturation go in line with selective binding of alkali resistant hemoglobin fraction to red cell membrane.
Korobov
V N
VN
Fedorovich
I P
IP
Klimishin
N I
NI
D000468:Alkalies / Q000378:metabolism; D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000097:blood*; D004900:Erythroblasts / Q000166:cytology; D004906:Erythrocyte Count; D004910:Erythrocyte Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000166:cytology; D006454:Hemoglobins / Q000737:chemistry / Q000378:metabolism; D006461:Hemolysis; D051379:Mice
D000468:Alkalies; D006454:Hemoglobins
Fiziko-khimicheskie i funktsional'nye svoĭstva gemoglobina mysheĭ, zarazhennykh kartsinomoĭ Erlikha.