Effect of endothelin 1 on plasma glucose and lipid levels in pygmy goats.
The effect of endothelin 1, a recently discovered vasoconstrictor hormone, on levels of plasma glucose and lipids was investigated in pygmy goats. Endothelin 1 was injected intraperitoneally (1.72 micrograms/kg BW) and blood samples were taken by puncturing the jugular vein immediately before and 60, 150 and 240 min post injection. Endothelin 1 in comparison to vehicle significantly increased plasma glucose and FFA levels, whereas plasma triglycerides were significantly reduced. Thus, beside its vasoconstrictive action, endothelin 1 also has metabolic effects. Whether these effects are directly caused by endothelin 1 or whether they are due to a release of a metabolic hormone, e.g. epinephrine, remains to be investigated.
Rossi
R
R
Institut für Veterinär-Physiologie, Universität Zürich, Switzerland.
Scharrer
E
E
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D016232:Endothelins / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006041:Goats / Q000097:blood*; D008055:Lipids / Q000097:blood*; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D016232:Endothelins; D005230:Fatty Acids, Nonesterified; D008055:Lipids; D014280:Triglycerides