beta-lactamases in Shigella.
The occurrence of resistance and production of beta-lactamases was investigated in 60 Shigella strains. Ampicillin resistance was found in 28 (47%) of the isolates, the resistance being more frequent in Sh. flexneri than in Sh. sonnei. All strains were susceptible to cefotaxime, mecillinam, and ciprofloxacin. The beta-lactamases produced by Shigella were similar to TEM-1, OXA-1, or the low-level chromosomally mediated cephalosporinase produced by Escherichia coli. The beta-lactamases produced by Sh. flexneri were most often the OXA-1-like enzymes.
Schumacher
H
H
Department of Hospital Infections and Antibiotics, Statens Seruminstitut, Copenhagen, Denmark.
Nir
M
M
Mansa
B
B
Grassy
A
A
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D012760:Shigella / Q000187:drug effects / Q000201:enzymology*; D001618:beta-Lactamases / Q000032:analysis* / Q000096:biosynthesis
D000900:Anti-Bacterial Agents; D001618:beta-Lactamases