Bioavailability of two formulations of acetylsalicylic acid gums.
Bioavailability studies have been performed with ten healthy volunteers on different dosage forms of acetylsalicylic acid (ASA) in order to assess the bioavailability of two different ASA gums compared with commercial ASA tablets. The results of this study show that ASA is more readily absorbed and eliminated after administration of gum formulations than after administration of tablets, but the bioavailability obtained from the gums was lower than that observed from the tablets.
Bousquet
E
E
Istituto di Chimica Farmaceutica e Tossicologia, Facoltà di Farmacia, Università di Catania, Italy.
Tirendi
S
S
Bonina
F P
FP
Montenegro
L
L
Bianchi
A
A
Ciampini
N
N
D000328:Adult; D001241:Aspirin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001682:Biological Availability; D002638:Chewing Gum; D006801:Humans; D008297:Male; D012459:Salicylates / Q000097:blood; D020156:Salicylic Acid
D002638:Chewing Gum; D012459:Salicylates; D020156:Salicylic Acid; D001241:Aspirin