Decreased renal phosphate threshold in patients with gout.
Serum and 24-hour urinary phosphate levels in primary gout patients and control subjects were measured. About 45% of gouty patients showed mild hypophosphatemia. However, mean 24-hour urinary excretion of phosphate was significantly elevated as compared with that of controls. Gouty patients showed a significantly decreased tubular reabsorption of phosphate and renal phosphate threshold. It seems that tubular phosphate transport in gouty patients is impaired, and this is the major cause of hypophosphatemia.
Nishida
Y
Y
Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Japan.
Ito
K
K
D000328:Adult; D006073:Gout / Q000378:metabolism*; D006801:Humans; D017136:Ion Transport; D007668:Kidney / Q000378:metabolism*; D007684:Kidney Tubules / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000097:blood / Q000378:metabolism* / Q000652:urine
D010710:Phosphates