[Selenium and malondialdehyde levels in the blood serum of men with normo- and hypercholesterolemia].
Lipid peroxidation is a free radical-mediated process. Malonaldehyde (MDA) is one of the products of reduction in this process. Selenium (Se) is a physiological free radical scavenger. In this paper the research on serum selenium (Se), serum MDA (MDAp) and MDA in low density lipoprotein (MDA1) in 52 men (age 38-52 years) will be presented. Plasma total cholesterol (T-chol), free cholesterol (F-chol), esterified cholesterol (E-chol) and triglyceride (Tg) concentrations were estimated also. It was found a significant negative correlation between MDA1 and T-chol (r = -0.4140, p = 0.0023), E-chol (r = -0.3947, p = 0.0038), F-chol (r = 0.4104, p = 0025). The patients were divided according to T-chol level (group I: T-chol greater than 5.2 mmol/l, group II: T-chol less than 5.2 mmol/l). Statistically significant negative correlation were found between: Se and MDAp in both groups (I: r = -0.7734, p = 0.0002, II: r = -0.6695, p = 0.0012), Se and MDA1 only in II group (r = -0.4693, p = 00368). There was no apparent relation between MDAp and T-chol, E-chol, F-chol and Tg.
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Katedry Diagnostyki Biochemicznej i Kliniki Chorób Metabolicznych Akademii Medycznej, Krakowie.
Jarzabek
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D000328:Adult; D001161:Arteriosclerosis / Q000209:etiology / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood*; D016166:Free Radical Scavengers; D005609:Free Radicals; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood* / Q000150:complications / Q000517:prevention & control; D008297:Male; D008315:Malondialdehyde / Q000037:antagonists & inhibitors / Q000097:blood*; D008875:Middle Aged; D012643:Selenium / Q000097:blood*
D016166:Free Radical Scavengers; D005609:Free Radicals; D008315:Malondialdehyde; D002784:Cholesterol; D012643:Selenium
Stezenie selenu i aldehydu dwumalonowego w surowicy mezczyzn z normo- i hipercholesterolemia.