[5-Fluoro (3H) pyrimidine-4-ones: synthesis, reactivity and pharmacological properties].
Fourteen fluoro pyrimidine-4-ones, four fluoro bispyrimidine-4-ones and two fluoro pyrimidine-4-ones with fused ring have been prepared. The reactivity of the carbonyl group of two pyrimidine-4-ones phosphorus oxychloride was studied. The 4-chloro pyrimidines reacted with ammonia or morpholine giving 4-substituted pyrimidines. Eight compounds are evaluated for their anti-inflammatory and anti-convulsivant properties: they were found to be weakly active against oedema and three of them protected rats form tonic convulsions.
De Melo
S J
SJ
Departamento de Antibioticos, Universidade Federal de Pernambuco, Recife, PE, Brésil.
Luu-Duc
C
C
Thomasson
F
F
Narcisse
G
G
Gaultier
C
C
D000818:Animals; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000494:pharmacology; D000927:Anticonvulsants / Q000138:chemical synthesis; D008297:Male; D051379:Mice; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D011744:Pyrimidinones
5-Fluoro (3H) pyrimidine-4-ones: synthèse, réactivité et propriétés pharmacologiques.