[The effect of the zinc content in the rations of experimental animals on the absorption, distribution and accumulation of cadmium chloride in the body with different methods of administration].
Intravenous (20 kBk) and intragastric (400 kBk) cadmium chloride administration to 45 white noninbred rat males kept for a month on a semisynthetic isocaloric diet including 0.0005 and 0.001% zinc were evaluated for absorption and distribution. Radionuclide findings provided the conclusions that: the absence or excess of zinc in the diet stimulates cadmium absorption from gastrointestinal tract; cadmium distribution in the viscera (the liver, kidneys, pancreas) varies with route of entry, the least accumulation of oral cadmium in the above viscera is observed in animals receiving optimal zinc quantities.
Bogomazov
M Ia
MIa
Garibian
G M
GM
D000284:Administration, Oral; D000821:Animal Feed; D000818:Animals; D002104:Cadmium / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D019256:Cadmium Chloride; D002712:Chlorides / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D015032:Zinc / Q000494:pharmacology*
D002712:Chlorides; D002104:Cadmium; D015032:Zinc; D019256:Cadmium Chloride
Vliianie soderzhaniia tsinka v ratsione éksperimental'nykh zhivotnykh na vsasyvanie, raspredelenie i nakoplenie khlorida kadmiia v organizme pri razlichnykh putiakh ego vvedeniia.