title: Plasma levels of the anaphylatoxins C3a and C4a in patients with IgA nephropathy/Henoch-Schönlein nephritis.
abstract: Measurements of plasma anaphylatoxins C3a and C4a were carried out as an indicator of in vivo complement activation in 46 patients suffering from IgA nephropathy/Henoch-Schönlein nephritis. There was a significant correlation between plasma levels of C4a and plasma creatinine and urea. We also found a significant correlation of plasma levels of C3a with plasma creatinine. We propose that the measurement of anaphylatoxin levels provides a sensitive indicator of in vivo complement activation and may serve as an additional method for monitoring the progress of disease in these patients.
authors.affiliation: Department of Immunology, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: H H
authors.initials: HH
authors.lastname: Abou-Ragheb
authors.forename: A J
authors.initials: AJ
authors.lastname: Williams
authors.forename: C B
authors.initials: CB
authors.lastname: Brown
authors.forename: A
authors.initials: A
authors.lastname: Milford-Ward
mesh_terms: D000328:Adult; D002940:Circadian Rhythm; D015926:Complement C3a / Q000032:analysis*; D015934:Complement C4a / Q000032:analysis*; D003404:Creatinine / Q000097:blood; D005260:Female; D005922:Glomerulonephritis, IGA / Q000097:blood*; D006801:Humans; D011695:IgA Vasculitis / Q000097:blood / Q000150:complications; D008297:Male; D008875:Middle Aged; D009393:Nephritis / Q000097:blood* / Q000209:etiology; D011507:Proteinuria / Q000097:blood; D014508:Urea / Q000097:blood
chemical_list: D015926:Complement C3a; D015934:Complement C4a; D014508:Urea; D003404:Creatinine