Influence of diabetes mellitus on renal vascular responses to bradykinin.
Streptozotocin-induced diabetes resulted in diminished vasodilator responses to bradykinin in the preconstricted isolated perfused kidney of the rat which were associated with decreased renal phospholipase A2 activity and reduced release of PGE2 into the renal venous effluent.
Quilley
J
J
Department of Pharmacology, New York Medical College, Valhalla 10595.
Sarubbi
D
D
McGiff
J C
JC
D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism / Q000503:physiopathology*; D015232:Dinoprostone / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000502:physiology / Q000503:physiopathology; D007672:Kidney Cortex / Q000201:enzymology; D007679:Kidney Medulla / Q000201:enzymology; D008297:Male; D008861:Microsomes / Q000201:enzymology; D008928:Mitochondria / Q000201:enzymology; D010656:Phenylephrine / Q000494:pharmacology; D010741:Phospholipases A / Q000378:metabolism*; D054467:Phospholipases A2; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D012079:Renal Circulation / Q000187:drug effects*
D010656:Phenylephrine; D010741:Phospholipases A; D054467:Phospholipases A2; D015232:Dinoprostone; D001920:Bradykinin