[LH and TSH receptors. A new family of G protein-coupled receptors].
Monoclonal antibodies have been raised against porcine LH receptor and allowed to clone the corresponding messenger RNA from testicular cells. Cross hybridisation with the LH receptor clone allowed to isolate a clone corresponding to the human TSH receptor from thyroids. The structure of both receptors have been determined. They show similarities but also differences to other G protein coupled receptors. In particular a large extracellular domain is specific of that new family of receptors. Variant forms of the LH receptor lacking transmembrane domains have been isolated. The obtention of monoclonal antibodies against both receptors allowed immunochemical and immunocytochemical studies to be performed. The human LH receptor gene have been localized to chromosome 2p21 and TSH receptor gene to chromosome 14q31. The complete organisation of the human TSH receptor gene has been determined.
Misrahi
M
M
Inserm, Unité 135, hôpital de Bicêtre, Le Kremlin-Bicêtre, France.
Loosfelt
H
H
Atger
M
M
Vu Hai
M T
MT
Gross
B
B
Meduri
G
G
Jolivet
A
A
Milgrom
E
E
D000818:Animals; D019204:GTP-Binding Proteins / Q000378:metabolism*; D011485:Protein Binding; D011974:Receptors, LH / Q000145:classification* / Q000378:metabolism; D011989:Receptors, Thyrotropin / Q000145:classification* / Q000378:metabolism
D011974:Receptors, LH; D011989:Receptors, Thyrotropin; D019204:GTP-Binding Proteins
Récepteurs de la LH et de la TSH. Une nouvelle famille de récepteurs couplés à des protéines G.