Structure determination and toxicity of a new microcystin from Microcystis aeruginosa strain 205.
A new hepatotoxic microcystin was isolated from the cyanobacterium Microcystis aeruginosa strain 205. Its structure was found to be [Dha7]microcystin-RR as determined by amino acid analysis, mass spectrometry and 1H NMR spectroscopy. LD50 value (i.p. mouse) of this toxin was 180 micrograms/kg. The 48 hr lethal concentration (48-hr-LC50) of the toxin for larvae of the yellow fever mosquito, Aedes aegypti, was 14.9 micrograms/ml.
Kiviranta
J
J
Department of Pharmacy, University of Helsinki, Finland.
Namikoshi
M
M
Sivonen
K
K
Evans
W R
WR
Carmichael
W W
WW
Rinehart
K L
KL
D000330:Aedes; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000503:physiopathology; D002851:Chromatography, High Pressure Liquid; D007814:Larva; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D052998:Microcystins; D046931:Microcystis / Q000737:chemistry*; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000633:toxicity
C492352:((Dha)7)-microcystin-RR; D000596:Amino Acids; D052998:Microcystins; D010456:Peptides, Cyclic