Bile salt/acid induction of DNA damage in bacterial cells: effect of taurine conjugation.
Bile salts and acids have been implicated in the etiology of colon cancer, possibly through their ability to cause DNA damage. Taurine-conjugated and nonconjugated forms of three bile salts and one bile acid were tested for DNA repair-inducing potential and for cellular toxicity in a recently developed Escherichia coli chromotest system. The taurine-conjugated forms of sodium deoxycholate and lithocholic acid had reduced ability to induce DNA repair. Also the taurine-conjugated form of lithocholic acid had a reduced lethal effect. These observations suggest that the biotransformation step, whereby bacteria in the intestine remove the taurine added to bile salts in the liver, may be significant in the etiology of colon cancer.
Zheng
Z Y
ZY
Department of Microbiology and Immunology, College of Medicine, University of Arizona, Tucson 85724.
Bernstein
C
C
D001647:Bile Acids and Salts / Q000494:pharmacology*; D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects*; D004269:DNA, Bacterial / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development; D008095:Lithocholic Acid / Q000494:pharmacology; D013654:Taurine / Q000378:metabolism*; D013655:Taurochenodeoxycholic Acid / Q000494:pharmacology; D013656:Taurocholic Acid / Q000494:pharmacology; D013657:Taurodeoxycholic Acid / Q000494:pharmacology; D013658:Taurolithocholic Acid / Q000494:pharmacology
D001647:Bile Acids and Salts; D004269:DNA, Bacterial; D013654:Taurine; D013655:Taurochenodeoxycholic Acid; D013657:Taurodeoxycholic Acid; D013658:Taurolithocholic Acid; D013656:Taurocholic Acid; D008095:Lithocholic Acid