Effect of endotoxin on rat liver regeneration after partial hepatectomy.
Lipopolysaccharide administered intraperitoneally to rats just after partial (70%) hepatectomy at the dose from 0.04 to 4 mg/kg body weight inhibited the induction of thymidylate synthase and thymidine kinase which are rate-determining enzymes of DNA synthesis, resulting in the impairment of DNA synthesis in the regenerating liver. This effect may be due to the hepato-toxic nature of endotoxin.
Tsukamoto
I
I
Department of Food Science and Nutrition, Nara Women's University, Japan.
Nakata
R
R
Kojo
S
S
D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D004731:Endotoxins / Q000494:pharmacology*; D004768:Enterotoxins / Q000494:pharmacology*; D004790:Enzyme Induction; D006498:Hepatectomy; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013937:Thymidine Kinase / Q000096:biosynthesis; D013940:Thymidylate Synthase / Q000096:biosynthesis
D001427:Bacterial Toxins; D004731:Endotoxins; D004768:Enterotoxins; C027952:salmonella toxin; D004247:DNA; D013940:Thymidylate Synthase; D013937:Thymidine Kinase