title: Modulation of phenotype and cytoskeleton architecture by interleukin-1 alpha in human osteoblast-like cells in vitro.
abstract: Interleukin-1 alpha, a growth factor produced by macrophages as well as many other types of cells, is able to modulate biosynthetic activities in bone cells. In this work, the authors show that the administration of interleukin-1 alpha to osteoblast-like cells in vitro induces a marked change in cell morphology, which becomes dendritic, with a smaller cellular body and numerous prolongations. The morphological changes are also accompanied by an altered expression in the pattern of cytoskeleton proteins.
authors.affiliation: Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi Perugia, Italia.
authors.forename: M
authors.initials: M
authors.lastname: Bodo
authors.forename: T
authors.initials: T
authors.lastname: Baroni
authors.forename: M
authors.initials: M
authors.lastname: Calvitti
authors.forename: F
authors.initials: F
authors.lastname: Carinci
authors.forename: N
authors.initials: N
authors.lastname: Arena
authors.forename: G
authors.initials: G
authors.lastname: Venti
mesh_terms: D002478:Cells, Cultured; D003598:Cytoskeletal Proteins / Q000032:analysis*; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis / Q000494:pharmacology*; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence; D010006:Osteoblasts / Q000737:chemistry / Q000166:cytology* / Q000187:drug effects*; D010641:Phenotype
chemical_list: D003598:Cytoskeletal Proteins; D007375:Interleukin-1