title: Liver transplant rejection and cholestasis: comparison of technetium 99m-diisopropyl iminodiacetic acid hepatobiliary imaging with liver biopsy.
abstract: To determine whether the scintigraphic evaluation of technetium-99m diisopropyl iminodiacetic acid (DISIDA) uptake and excretion can distinguish among liver transplant patients with biopsy evidence for rejection, cholestasis or neither condition, we reviewed scintigrams and biopsies in 36 patients. There were 76 scintigrams with corresponding biopsies. Uptake and excretion were graded from image data on scales reflecting normal through severely abnormal values. Biopsies were evaluated for findings of cholestasis and rejection. The majority of scintigrams demonstrated normal uptake (60/75, 80%) and delayed excretion (65/76, 85%), which was most marked immediately after transplantation. One-way analysis of variance showed that the mean excretion values significantly differed between patients with normal biopsies and those with cholestasis and/or rejection (P = 0.0003). However, mean uptake scores demonstrated no statistically significant difference between these two groups of patients (P = 0.1). These findings suggest that 99mTc-DISIDA scintigraphy can differentiate between transplants with and without rejection/cholestasis but not between rejection and cholestasis. If 99mTc-DISIDA excretion is normal, rejection and cholestasis are unlikely.
authors.affiliation: University of Minnesota Hospital and Clinic, Department of Radiology, Minneapolis 55455.
authors.forename: C M
authors.initials: CM
authors.lastname: Engeler
authors.forename: C C
authors.initials: CC
authors.lastname: Kuni
authors.forename: R
authors.initials: R
authors.lastname: Nakhleh
authors.forename: C E
authors.initials: CE
authors.lastname: Engeler
authors.forename: R P
authors.initials: RP
authors.lastname: duCret
authors.forename: R J
authors.initials: RJ
authors.lastname: Boudreau
mesh_terms: D002779:Cholestasis / Q000175:diagnosis*; D005260:Female; D006084:Graft Rejection / Q000175:diagnosis*; D006801:Humans; D007098:Imino Acids; D008099:Liver / Q000000981:diagnostic imaging* / Q000473:pathology*; D016031:Liver Transplantation / Q000000981:diagnostic imaging / Q000276:immunology* / Q000473:pathology; D008297:Male; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D019785:Technetium Tc 99m Disofenin
chemical_list: D007098:Imino Acids; D015609:Organotechnetium Compounds; D019785:Technetium Tc 99m Disofenin