Vascular wall kininogen concentration is inversely related to intrinsic kininogenase in spontaneously hypertensive rats.
We determined kininogen concentration and kininogenase activity in the blood-free, aorta homogenates of 15 week old spontaneously hypertensive rats (SHR) and in their age-matched wistar kyoto (WKY) controls. Active kininogenase in the SHR was only 18% of the WKY controls. Thus, the kininogen concentration was inversely related to kininogenase activity suggesting a local interaction of these components and possible generation of kinins within the vascular wall.
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Evans Memorial Department of Clinical Research, University Hospital, Boston University School of Medicine, MA 02118.
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D000818:Animals; D001011:Aorta / Q000378:metabolism*; D001794:Blood Pressure; D066298:In Vitro Techniques; D007610:Kallikreins / Q000378:metabolism*; D007704:Kininogens / Q000378:metabolism*; D007705:Kinins / Q000032:analysis; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D011863:Radioimmunoassay; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D007704:Kininogens; D007705:Kinins; D007610:Kallikreins