title: Adenocarcinoma of the proximal small intestine. A marker for familial and multicentric cancer?
abstract: BACKGROUND
  Adenocarcinoma of the small intestine is uncommon. The Hawaii Tumor Registry (HTR) has identified 49 of these tumors since 1960, and the Japan-Hawaii Cancer Study (JHCS) has identified only four of these tumors among a cohort of 8006 Hawaiian-Japanese men followed up for a period of 22 years. Each of the four men reported by the JHCS had multicentric gastrointestinal cancers.
  
  
  METHODS
  Newly diagnosed cancers are recorded separately by the HTR and JHCS, and linkage is maintained between the two files. Family histories are available from the JHCS, and these are supplemented by a state population file maintained by the Department of Genetics, University of Hawaii.
  
  
  RESULTS
  Five men, all Japanese, were found to have carcinoma of the proximal small intestine. Each had multicentric carcinomas of the gastrointestinal tract. Carcinoma of the stomach and colon was found in the primary relatives of each of four men whose families lived in Hawaii.
  
  
  CONCLUSIONS
  The familial clustering of uncommon neoplasms (small bowel carcinoma and multicentric large bowel carcinoma), and the concurrence of gastric and colonic carcinoma suggests that these subjects have a genetic trait that increases susceptibility to a broad range of carcinogens.
authors.affiliation: Japan-Hawaii Cancer Study, Kuakini Medical Center, Honolulu 96817.
authors.forename: G N
authors.initials: GN
authors.lastname: Stemmermann
authors.forename: M T
authors.initials: MT
authors.lastname: Goodman
authors.forename: A M
authors.initials: AM
authors.lastname: Nomura
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000235:genetics*; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003110:Colonic Neoplasms / Q000453:epidemiology / Q000235:genetics; D004379:Duodenal Neoplasms / Q000453:epidemiology / Q000235:genetics; D005192:Family Health; D005260:Female; D006254:Hawaii / Q000453:epidemiology; D006801:Humans; D007078:Ileal Neoplasms / Q000453:epidemiology / Q000235:genetics; D007414:Intestinal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D007564:Japan / Q000208:ethnology; D007580:Jejunal Neoplasms / Q000453:epidemiology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000453:epidemiology / Q000235:genetics*; D010375:Pedigree; D012004:Rectal Neoplasms / Q000453:epidemiology / Q000235:genetics; D012307:Risk Factors