title: [The infusion of high-dose immunoglobulins in a case of idiopathic thrombocytopenic purpura].
abstract: Idiopathic thrombocytopenic purpura (ITP) is a disease characterized by the presence of circulating antiplatelet antibodies, which can cause platelet destruction, through the mediation of the reticuloendothelial system (RES). We report on a patient affected with ITP insensible to first line steroid therapy, who achieved a complete response following the administration of high-dose immunoglobulins (HDIgG, 400 mg/kg/die for 5 days), in association with decreasing doses of steroids. At the end of the treatment with immunoglobulins, the patient presented a normal platelet count and, up to date, 5 moths from the end of therapy, he is in good shape and presents normal platelets values.
authors.affiliation: Divisione di Medicina, Ospedale Civile, Tortona, Alessandria.
authors.forename: I
authors.initials: I
authors.lastname: Casagranda
authors.forename: P
authors.initials: P
authors.lastname: Davio
authors.forename: M
authors.initials: M
authors.lastname: Moroni
authors.forename: G
authors.initials: G
authors.lastname: Nastasi
authors.forename: C
authors.initials: C
authors.lastname: Porta
mesh_terms: D000293:Adolescent; D001853:Bone Marrow / Q000473:pathology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D008297:Male; D010976:Platelet Count / Q000187:drug effects; D011241:Prednisone / Q000008:administration & dosage; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood / Q000628:therapy*; D012074:Remission Induction
chemical_list: D016756:Immunoglobulins, Intravenous; D011241:Prednisone
vernacular_title: Infusione di immunoglobuline ad alte dosi in un caso di porpora trombocitopenica idiopatica.