[The therapeutic effect of diazepam in dichlorvos poisoning].
In order to study the influence of diazepam on both cholinergistic and non-cholinergistic (stressogenic) effects of phosphororganic insecticide dichlorovos, both the activity of cholinesterase in selected organs and blood as well as biochemical markers of stress (plasma corticosterone, tyrosine aminotransferase activity in the liver) have been applied. Comparing the course of diazepam-treated and untreated dichlorovos intoxication, cholinesterases showed greater increase in inhibition in the first case. There was smaller decrease in activity of acetylcholinesterase in CNS and diaphragm compared with untreated intoxication. Although the changes of plasma corticosterone level were entirely corresponding to those of untreated intoxication, there was still greater increase in activity of tyrosine aminotransferase when compared with untreated intoxication. A marked increase in activity of tyrosine aminotransferase is more convenient for an intoxicated organism, because tyrosine aminotransferase stimulates gluconeogenesis. Even in absence of a complete elimination of cholinergistic and stressogenic effects of dichlorovos, diazepam, as a drug, influenced markedly their course. Thus its significance of component of a complexive atropine-oxime therapy of the intoxication with organophosphates appears to be undiscussible and wider than stressed usually.
Kassa
J
J
D000818:Animals; D003975:Diazepam / Q000627:therapeutic use*; D004006:Dichlorvos / Q000506:poisoning*; D008297:Male; D011041:Poisoning / Q000188:drug therapy; D051381:Rats; D017208:Rats, Wistar
D004006:Dichlorvos; D003975:Diazepam
Lécebný úcinek diazepamu na intoxikaci dichlorvosem.