[The phenomenon of tachyphylaxis in the pathogenesis of an experimental infectious process].
Experiments on mice have revealed that the development of experimental purulent infection is accompanied by a considerable increase in the nonspecific resistance of the animals to additional infection with unrelated bacteria (the effect of tachyphylaxis). Morphologically, this is manifested by the rapid limitation of the focus of inflammation at the site of inoculation of the superinfecting agent. The state of the phagocytic apparatus is of great importance for this phenomenon as disturbances in the macrophage activity caused by the injection of carrageenan abolish the protective effect of primary infection. The phenomenon of tachyphylaxis has been shown to play a certain role in the prevention of the septic generalization of the process and in resistance to superinfection.
Barsukov
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D000818:Animals; D001424:Bacterial Infections / Q000209:etiology / Q000276:immunology*; D004927:Escherichia coli Infections / Q000209:etiology / Q000276:immunology; D007114:Immunization / Q000379:methods; D007153:Immunologic Deficiency Syndromes / Q000209:etiology / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D011512:Proteus Infections / Q000209:etiology / Q000276:immunology; D011514:Proteus vulgaris; D011552:Pseudomonas Infections / Q000209:etiology / Q000276:immunology; D013203:Staphylococcal Infections / Q000209:etiology / Q000276:immunology; D015163:Superinfection / Q000209:etiology / Q000276:immunology; D013618:Tachyphylaxis
Fenomen takhifilaksii v patogeneze éksperimental'nogo infektsionnogo protsessa.