Prediction of late cardiac events by dipyridamole thallium imaging in patients undergoing elective vascular surgery.
Dipyridamole thallium scintigraphy has previously been shown to have prognostic value in the preoperative assessment of patients scheduled to undergo vascular surgery, but its effect on the long-term outcome is less well-defined. In the largest series to date, dipyridamole thallium scanning was performed in 360 patients before elective vascular surgery and survivors were followed for a mean of 31 months. In the 327 patients who underwent vascular surgery, operative death and nonfatal myocardial infarction occurred in 4.9 and 6.7%, respectively. A cardiac event (nonfatal myocardial infarction or cardiac death) occurred in 14.4% of patients with a transient thallium defect, as opposed to 1% with a normal scan (p < 0.001). Logistic regression analysis revealed that the best predictor of a perioperative event was the presence of a reversible thallium defect, elevating the risk by 4.3-fold. Late cardiac events occurred in 53 (15.2%) surgical survivors or nonsurgically treated patients. Patients with a fixed perfusion abnormality had a 24% late event rate, compared with 4.9% in those with a normal dipyridamole thallium study (p < 0.01). Cox analysis demonstrated that a fixed thallium defect was the strongest factor for predicting a late event and increased the relative risk by almost fivefold. A history of congestive heart failure was the only significant variable that contributed additional value to that of a fixed defect alone. Life-table analysis confirmed the strong relation of a fixed defect to cardiac event free survival (p < 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS)
Hendel
R C
RC
Department of Medicine (Division of Cardiovascular Medicine), University of Massachusetts Medical Center, Worcester.
Whitfield
S S
SS
Villegas
B J
BJ
Cutler
B S
BS
Leppo
J A
JA
D000368:Aged; D016757:Death, Sudden, Cardiac; D004176:Dipyridamole; D005260:Female; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000209:etiology; D011183:Postoperative Complications; D011300:Preoperative Care; D011877:Radionuclide Imaging; D012307:Risk Factors; D013794:Thallium Radioisotopes; D014656:Vascular Surgical Procedures
D013794:Thallium Radioisotopes; D004176:Dipyridamole