Fatal pneumonia caused by Corynebacterium group JK after treatment of Staphylococcus aureus pneumonia.
A 76-year-old man who was admitted to the hospital because of chronic renal insufficiency and chronic hepatitis died of Corynebacterium group JK pneumonia, after showing a slight improvement by treatment of Staphylococcus aureus with sulbactam/cefoperazone and minocycline. Transtracheal aspiration (TTA) just before his death revealed numerous gram-positive bacilli phagocytized by many neutrophils and more than 10(8) colony forming units (CFU)/ml of Corynebacterium group JK. A drug susceptibility test showed Corynebacterium group JK was resistant to many antibiotics, with the exception of vancomycin and amikacin.
Yoshitomi
Y
Y
Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
Kohno
S
S
Koga
H
H
Maesaki
S
S
Higashiyama
Y
Y
Matsuda
H
H
Mitsutake
K
K
Miyazaki
Y
Y
Yamada
H
H
Hara
K
K
D000368:Aged; D002438:Cefoperazone / Q000627:therapeutic use; D003352:Corynebacterium / Q000187:drug effects / Q000302:isolation & purification*; D003354:Corynebacterium Infections / Q000150:complications*; D004198:Disease Susceptibility; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D006801:Humans; D016867:Immunocompromised Host; D007676:Kidney Failure, Chronic / Q000150:complications; D008297:Male; D008911:Minocycline / Q000627:therapeutic use; D009894:Opportunistic Infections / Q000382:microbiology*; D011014:Pneumonia / Q000382:microbiology*; D011023:Pneumonia, Staphylococcal / Q000150:complications*; D013407:Sulbactam / Q000627:therapeutic use
D002438:Cefoperazone; D008911:Minocycline; D013407:Sulbactam