title: Increase of plasma IL-6 concentration with age in healthy subjects.
abstract: The present study demonstrated that plasma IL-6 concentration was higher in older subjects than in younger ones and significantly in the male group (P = 0.02); Spearman rank correlation showed that plasma IL-6 concentration was positively correlated with age (r = 0.28, N = 55, P < 0.05); there was a highly significant correlation between the concentrations in plasma IL-6 and IL-1 alpha (r = 0.51, N = 52, P < 0.001). These findings suggest the possibility that age-related changes of plasma IL-6 and IL-1 alpha may provide a pathological basis for the susceptibility to such illness as commonly occurs in elderly people, especially Alzheimer's disease as the two interleukins can induce the production of alpha 1-antichymotrypsin and beta-amyloid protein precursor.
authors.affiliation: Institute of Biological Psychiatry, Schizophrenia Association of Great Britain, Bangor, Gwynedd, U.K.
authors.forename: J
authors.initials: J
authors.lastname: Wei
authors.forename: H
authors.initials: H
authors.lastname: Xu
authors.forename: J L
authors.initials: JL
authors.lastname: Davies
authors.forename: G P
authors.initials: GP
authors.lastname: Hemmings
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood*; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D012737:Sex Factors
chemical_list: D007375:Interleukin-1; D015850:Interleukin-6