title: Assessment of anti-HIV activity of some benzimidazolylthiazoles.
abstract: Benzimidazolylthiazoles 2 were synthesized by condensing 1H-benzimidazole-2-acetonitrile (1) with sulphur and isothiocyanates. The syntheses of the Schiff bases 3, thioureas 4, and thiazolopyrimido[1,6-a]benzimidazoles 5 and 6 are also described. Seven compounds were evaluated in vitro against human HIV, however, no significant activity was observed with any of these compounds.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, A.R. Egypt.
authors.forename: E A
authors.initials: EA
authors.lastname: Badawey
authors.forename: A A
authors.initials: AA
authors.lastname: Hazzaa
authors.forename: S M
authors.initials: SM
authors.lastname: Rida
authors.forename: H T
authors.initials: HT
authors.lastname: Fahmy
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D006678:HIV / Q000187:drug effects*; D006801:Humans
chemical_list: D000998:Antiviral Agents; D001562:Benzimidazoles