Isolated granulomatous angiitis of the spinal cord.
We describe a 31-year-old diabetic man, with granulomatous angiitis confined to the spinal cord, who developed rapidly progressive spastic paraplegia, clinically interpreted as being secondary to a spinal cord infarct. At the time of autopsy, vasculitis was limited to the spinal cord, without involvement of cerebral vessels. The inflammatory cells were predominantly CD4+ T lymphocytes, with few CD8+ T and B lymphocytes. The phenotypical composition of the inflammatory infiltrate is similar to that described in other granulomatous disorders such as sarcoidosis and tuberculin reaction.
Caccamo
D V
DV
Department of Pathology, Henry Ford Hospital, Detroit, MI 48202.
Garcia
J H
JH
Ho
K L
KL
D000328:Adult; D006099:Granuloma / Q000150:complications / Q000473:pathology*; D006801:Humans; D008297:Male; D010264:Paraplegia / Q000209:etiology; D013118:Spinal Cord Diseases / Q000150:complications / Q000473:pathology*; D014657:Vasculitis / Q000150:complications / Q000473:pathology*