Amoxycillin-resistant oral streptococci and experimental infective endocarditis in the rabbit.
The ability of three amoxycillin-resistant strains of Streptococcus sanguis 254, 24 and 297 (MIC 40 mg/L) to cause infective endocarditis (IE) in the rabbit was investigated. These strains all produced infection in the rabbit, as did an antibiotic sensitive control strain NCTC 7864. Prophylactic amoxycillin (400 mg/kg body weight) administered one hour before bacterial challenge prevented 80% of the animals developing IE irrespective of the challenging strain. It is concluded that amoxycillin-resistant strains of S. sanguis can cause IE and that amoxycillin prophylaxis can still be effective against these bacteria.
Longman
L P
LP
Department of Clinical Dental Sciences, University of Liverpool, UK.
Marsh
P D
PD
Martin
M V
MV
D000658:Amoxicillin / Q000627:therapeutic use*; D000668:Ampicillin Resistance; D000818:Animals; D004697:Endocarditis, Bacterial / Q000382:microbiology / Q000517:prevention & control*; D008826:Microbial Sensitivity Tests; D011817:Rabbits; D013290:Streptococcal Infections / Q000382:microbiology / Q000517:prevention & control*; D013298:Streptococcus sanguis / Q000187:drug effects* / Q000472:pathogenicity
D000658:Amoxicillin