Suppression of renal disease and arthritis, and prolongation of survival in MRL-lpr mice treated with an extract of Tripterygium wilfordii Hook f.
OBJECTIVE
Treatment of MRL-lpr/lpr mice with Tripterygium wilfordii Hook f (TWHf) to evaluate its effects on mortality, renal disease, and arthritis.


METHODS
Mice were fed water (group A, control), TWHf (group B), or first water and then TWHf (group C) from age 7 weeks until age 21 weeks.


RESULTS
Arthritis and glomerulonephritis were decreased in groups B and C mice, and survival was increased in group B mice.


CONCLUSIONS
TWHf decreases the mortality rate, and severity of glomerulonephritis and arthritis in MRL-lpr/lpr mice.
Gu
W Z
WZ
Department of Medicine, Montreal General Hospital Research Institute, Quebec, Canada.
Banerjee
S
S
Rauch
J
J
Brandwein
S R
SR
D000818:Animals; D001168:Arthritis / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D006614:Hindlimb; D007596:Joints / Q000473:pathology; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000235:genetics / Q000401:mortality; D008198:Lymph Nodes / Q000473:pathology; D051379:Mice; D008817:Mice, Mutant Strains; D010936:Plant Extracts / Q000494:pharmacology*; D011507:Proteinuria / Q000517:prevention & control; D016019:Survival Analysis
D010936:Plant Extracts