title: Tissue plasminogen activator release in chronic venous hypertension due to heart failure.
abstract: In order to study the effects of chronic venous hypertension due to heart failure on blood fibrinolytic activity, tissue plasminogen activator (t-PA) antigen, plasminogen activator inhibitor 1 (PAI-1) antigen, t-PA activity and PAI activity were measured before and after venous occlusion of the arm for 20 min in 15 patients with right-sided heart failure, 15 patients with left-sided heart failure, and 30 control healthy subjects. Central venous pressure, measured by observing the jugular veins, was above 15 cm of the blood column in all patients with right-sided heart failure, and normal (below 8 cm) in all patients with left-sided heart failure and control subjects. There was no difference in the basal concentrations of t-PA (11.0, 10.2 and 10.8 ng/ml; all values medians) and PAI-1 antigens and their activities between right and left-sided heart failure and the control subjects. After the occlusion, t-PA antigen increased significantly less in right-sided heart failure (28.6 ng/ml) than in left-sided heart failure and the control subjects (54.5 and 45.9 ng/ml, respectively). It was concluded that the poor increase in fibrinolytic activity that had already been reported in patients with heart failure, was due to low t-PA release during occlusion and not to a high basal PAI level. It was limited to the patients with right-sided heart failure and was probably the consequence of chronic systemic venous hypertension.
authors.affiliation: University Medical Centre, Trnovo Hospital of Internal Medicine, Ljubljana, Slovenia.
authors.forename: I
authors.initials: I
authors.lastname: Keber
authors.forename: D
authors.initials: D
authors.lastname: Keber
authors.forename: M
authors.initials: M
authors.lastname: Stegnar
authors.forename: N
authors.initials: N
authors.lastname: Vene
mesh_terms: D000328:Adult; D000368:Aged; D000941:Antigens / Q000097:blood*; D002303:Cardiac Output, Low / Q000150:complications / Q000503:physiopathology*; D002908:Chronic Disease; D005342:Fibrinolysis / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000276:immunology*; D010959:Tissue Plasminogen Activator / Q000097:blood* / Q000276:immunology
chemical_list: D000941:Antigens; D017395:Plasminogen Activator Inhibitor 1; D010959:Tissue Plasminogen Activator