Anti-granuloma activity of Iraqi Withania somnifera.
The granuloma-tissue formation inhibiting activity of various fractions of an extract of the aerial parts of Withania somnifera were established using subcutaneous cotton-pellet implantation in rats. Antiinflammatory activity was retained in the methanolic fractions of the plant extract and was comparable to that of a 5 mg/kg dose of hydrocortisone sodium succinate. Activity was attributed to the high content of biologically active steroids in the plant, of which withaferin A is known to be a major component.
al-Hindawi
M K
MK
Pharmacognosy and Pharmacology Department, Scientific Research Council, Baghdad, Iraq.
al-Khafaji
S H
SH
Abdul-Nabi
M H
MH
D000311:Adrenal Glands / Q000187:drug effects; D000818:Animals; D003368:Gossypium; D006097:Granulation Tissue / Q000187:drug effects / Q000473:pathology; D006099:Granuloma / Q000188:drug therapy* / Q000473:pathology; D007493:Iraq; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts