The familial relation of personality disorders (DSM-II-R) to unipolar major depression.
Four hundred and fifty directly interviewed relatives of probands with non-psychotic unipolar major depression and 320 directly interviewed relatives of controls were compared by the prevalences of personality disorders (P.D.) as defined by DSM-III-R, in relation to presence or absence of the relatives' affective disorder. Overall, there was only a trend for an increased risk for P.D. in relatives of depressed patients. However, P.D. and unipolar major depression co-occurred more frequently in relatives than expected by chance. It is suggested that this association is mainly due to non-familial factors. Compared with other P.D., the relationship of borderline P.D. to major depression was not substantially stronger.
Maier
W
W
Department of Psychiatry, University of Mainz, FRG.
Lichtermann
D
D
Minges
J
J
Heun
R
R
D000328:Adult; D001883:Borderline Personality Disorder / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D016241:Child of Impaired Parents / Q000523:psychology; D003866:Depressive Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010553:Personality Development; D010554:Personality Disorders / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D010641:Phenotype; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors