[Evaluation of loss of active heparin in the peritoneal cavity during intermittent peritoneal dialysis].
Our studies aimed at determining a loss of active heparin from the peritoneal cavity after its intraperitoneal administration (250 JU/l of dialysis fluid) in 16 patients treated because of the end-stage renal failure with intermittent peritoneal dialysis and at comparing heparin influx clearance with that of glucose. It has been shown that heparin used in this dose loses 60-70% of its activity after 20-minute equilibration of dialysis fluid in the peritoneal cavity. Heparin influx clearance is higher than that of glucose but it depends on utilization of heparin in peritoneal cavity rather than on its penetration to the blood circulation.
Kuźniak
J
J
Zakładu Analityki Medycznej Katedry Onkologii AM.
Grzegorzewska
A
A
D000328:Adult; D001202:Ascitic Fluid / Q000378:metabolism*; D005260:Female; D015312:Hemodialysis Solutions / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006493:Heparin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000628:therapy*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D010529:Peritoneal Cavity; D010530:Peritoneal Dialysis / Q000379:methods*; D013997:Time Factors
D015312:Hemodialysis Solutions; D006493:Heparin
Ocena ubytku czynnej heparyny w jamie otrzewnej podczas przerywanej dializy otrzewnowej.