Synthesis and antibacterial activity of 1-substituted-methyl carbapenems.
The synthesis of the 1 alpha- and the 1 beta-substituted (fluoro, cyano, hydroxy and acetoxy)-methyl carbapenems having a 2-(1,3,4-thiadiazol-2-yl)thiomethyl side chain are described, and their in vitro antibacterial activities are compared with the corresponding 1 beta-methyl carbapenems together with imipenem. The synthesis and antibacterial activity of the 1 beta-substituted (fluoro and cyano)-methyl carbapenems having 2-(1-alkyl-4-pyridinio)thiomethyl side chains are also described.
Sendo
Y
Y
Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
Kii
M
M
Sakanoue
M
M
Motokawa
K
K
Kimura
Y
Y
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D015780:Carbapenems / Q000138:chemical synthesis* / Q000494:pharmacology; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D015780:Carbapenems