T1 values of phosphomonoester and phosphocreatine of brain show no significant change during development.
Changes in apparent 31P spin-lattice relaxation times (T1) associated with brain development were investigated in rat pups. While analysis of variance showed strong age dependency in [PME]/[ATP] and [PCr]/[ATP], the T1 values of PME, PCr, and ATP did not show any age dependency. The studies indicate that in contrast to the data which indicated aging-related changes in the T1 values of PME, the observed changes in PME during neonatal development are likely to be quantitative in nature.
Hida
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Neurochemistry Research Laboratory, Department of Veterans Affairs Medical Center, Martinez, California 94553.
Kwee
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IL
Nakada
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D000255:Adenosine Triphosphate / Q000032:analysis; D000818:Animals; D001921:Brain / Q000254:growth & development*; D001923:Brain Chemistry; D009682:Magnetic Resonance Spectroscopy; D010755:Organophosphates / Q000032:analysis*; D010725:Phosphocreatine / Q000032:analysis*; D051381:Rats; D017207:Rats, Sprague-Dawley
D010755:Organophosphates; D010725:Phosphocreatine; D000255:Adenosine Triphosphate