title: Alcohol exacerbates behavioral and neurochemical effects of rat spinal cord trauma.
abstract: Acute alcohol intoxication may exacerbate the consequences of central nervous system trauma, although the mechanism is uncertain. Effects of acute ethanol administration on behavioral and neurochemical changes were examined in rats after traumatic spinal cord injury. Survival rates were reduced and posttraumatic neurologic function worsened in ethanol-treated as compared with saline-treated controls. Ethanol-treated rats had significantly lower tissue levels of excitatory amino acids and higher levels of free fatty acids, thromboxane, and lactic acid than did controls. Tissue magnesium concentration was significantly reduced by trauma and recovered more slowly in ethanol-treated rats. Enhanced phospholipid hydrolysis with free fatty acid and thromboxane accumulation, increased release of excitatory amino acids, and decreased tissue magnesium levels may each serve to worsen secondary tissue damage and diminish neurologic recovery after spinal cord injury associated with acute alcohol intoxication.
authors.affiliation: Department of Neurology, Georgetown University School of Medicine, Washington, DC.
authors.forename: P S
authors.initials: PS
authors.lastname: Halt
authors.forename: R A
authors.initials: RA
authors.lastname: Swanson
authors.forename: A I
authors.initials: AI
authors.lastname: Faden
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001834:Body Water / Q000737:chemistry; D002412:Cations; D002784:Cholesterol / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D007796:Laminectomy; D051381:Rats; D013119:Spinal Cord Injuries / Q000378:metabolism*; D013929:Thromboxane B2 / Q000378:metabolism
chemical_list: D000596:Amino Acids; D002412:Cations; D005230:Fatty Acids, Nonesterified; D007773:Lactates; D019344:Lactic Acid; D000431:Ethanol; D013929:Thromboxane B2; D002784:Cholesterol