title: Griseofulvin in the treatment of oral lichen planus: adverse drug reactions, but little beneficial effect.
abstract: An open trial was conducted of systemic griseofulvin in the treatment of oral lichen planus. Eleven patients completed the trial. Symptomatic benefit was noted in 21% of the twenty-three patients starting the trial, but there was no clinical improvement, and about one half of the group starting the trial suffered adverse drug reactions.
authors.affiliation: University Department of Oral Medicine Surgery, and Pathology, Bristol Dental Hospital and School, UK.
authors.forename: R W
authors.initials: RW
authors.lastname: Matthews
authors.forename: C
authors.initials: C
authors.lastname: Scully
mesh_terms: D000284:Administration, Oral; D006118:Griseofulvin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006261:Headache / Q000139:chemically induced; D006801:Humans; D008010:Lichen Planus / Q000188:drug therapy* / Q000473:pathology; D009059:Mouth Diseases / Q000188:drug therapy* / Q000473:pathology; D009325:Nausea / Q000139:chemically induced; D013607:Tablets; D017211:Treatment Failure
chemical_list: D013607:Tablets; D006118:Griseofulvin