title: The effect of Vivida cream as compared with placebo cream in the treatment of sun-damaged or age-damaged facial skin.
abstract: Vivida when used orally has been previously shown to be effective in treating degenerated skin of women. In the present study, 30 women with moderate to severe sun-damaged facial skin applied Vivida cream twice daily for 120 days on one side of the face and placebo to the other. Vivida was significantly (P < 0.001) more effective than placebo in improving wrinkles. The effects of Vivida cream on mottles and telangiectasis were also significantly (P < 0.01) greater than those of placebo. Scanner measurement showed that epidermal thickness increased from 0.13 mm to 0.29 mm and dermal thickness from 0.91 mm to 1.29 mm on the Vivida-treated side; only minimal changes were observed on the placebo-treated side. The elasticity index increased from about 50% to 69% on the Vivida-treated side and from 49% to 50% on the placebo-treated side.
authors.affiliation: Helsinki Research Centre, Finland.
authors.forename: A
authors.initials: A
authors.lastname: Lassus
authors.forename: A
authors.initials: A
authors.lastname: Eskelinen
authors.forename: J
authors.initials: J
authors.lastname: Santalahti
mesh_terms: D000284:Administration, Oral; D004311:Double-Blind Method; D005148:Facial Dermatoses / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D009824:Ointments; D011134:Polysaccharides / Q000008:administration & dosage / Q000627:therapeutic use*; D015595:Skin Aging / Q000187:drug effects*; D013471:Sunburn / Q000150:complications*
chemical_list: D009824:Ointments; D011134:Polysaccharides; C077444:Vivida