title: [Effect of hyperglycemia and hyperthermia on liver mitochondrial respiration and blood glucose content of rats during postnatal ontogenesis].
abstract: Correlation between glucose level in blood and liver mitochondrial energetics of 1, 10, 20-days rats under hyperglycemia and high environmental temperature (38 degrees C) has been studied. Glucose feeding led to a significant increase of glucose content in blood, this increase being less at hyperthermia. Glucose feeding strengthened the oxidation of such intermediates as succinate (Krebs cycle), pyruvate and malate (hydrocarbonates) and caprylate (lipid). High environmental temperature with hyperglycemia suppresses the liver mitochondria breathing, hydrocarbon and lipid intermediates being used; the suppression is less in the presence of succinate. It is found that liver mitochondria of growing rats at different experimental conditions oxidize different intermediates with various rates. These data can be explained in the light of ontogenetic evolution of the energetic apparatus. It is supposed that exogenic glucose is the factor which activates growing processes of animals and to certain extent diminishes the negative influence of hyperthermia on the organism.
authors.forename: E S
authors.initials: ES
authors.lastname: Makhmudov
authors.forename: A A
authors.initials: AA
authors.lastname: Alimukhamedov
authors.forename: R I
authors.initials: RI
authors.lastname: Akhmerov
authors.forename: R N
authors.initials: RN
authors.lastname: Babaeva
authors.forename: G Kh
authors.initials: GKh
authors.lastname: Baratova
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism*; D001831:Body Temperature / Q000502:physiology*; D002210:Caprylates / Q000378:metabolism; D006943:Hyperglycemia / Q000097:blood / Q000378:metabolism*; D008293:Malates / Q000378:metabolism; D008930:Mitochondria, Liver / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology*; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D051381:Rats; D017208:Rats, Wistar; D013386:Succinates / Q000378:metabolism; D019802:Succinic Acid
chemical_list: D001786:Blood Glucose; D002210:Caprylates; D008293:Malates; D011773:Pyruvates; D013386:Succinates; C030298:malic acid; D019289:Pyruvic Acid; D019802:Succinic Acid
vernacular_title: Vliianie giperglikemii i gipertermii na dykhanie mitochondriĭ soderzhanie gliukozy v krovi krys v postnatal'nom ontogeneze.