title: Successful therapy of peritoneal mesothelioma with intraperitoneal chemotherapy alone. A case report.
abstract: Malignant peritoneal mesothelioma is a disease that remains relatively refractory to conventional intravenous chemotherapy with currently available agents. Single-agent and combination chemotherapy offer a response rate of 20%. Direct intraperitoneal administration of some chemotherapeutic agents results in a significant pharmacologic advantage with much greater area under the concentration versus time curve (AUC). We report a case of a patient with peritoneal mesothelioma treated with combination intraperitoneal cisplatin and Ara-C who achieved a pathologic complete remission. This patient is still alive and has been in complete remission for 53 months. This combination of intraperitoneal chemotherapy deserves further evaluation in malignant mesothelioma.
authors.affiliation: Section of Medical Oncology, University of Miami School of Medicine, Florida 33121.
authors.forename: M L
authors.initials: ML
authors.lastname: Garcia Moore
authors.forename: N
authors.initials: N
authors.lastname: Savaraj
authors.forename: L G
authors.initials: LG
authors.lastname: Feun
authors.forename: E
authors.initials: E
authors.lastname: Donnelly
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003561:Cytarabine / Q000008:administration & dosage; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008654:Mesothelioma / Q000188:drug therapy*; D010534:Peritoneal Neoplasms / Q000188:drug therapy*; D012074:Remission Induction
chemical_list: D003561:Cytarabine; D002945:Cisplatin