Embryo-derived platelet activating factor.
Platelet-activating factor (PAF) is secreted by the preimplantation embryo of a number of species. The role of this secretion is yet to be fully elucidated. Evidence to date indicates that it has an important function as an autocrine stimulant of embryonic metabolism, growth and viability. Production of PAF by embryos appears to be severely compromised in vitro. This may be a major cause of reduced embryo viability following embryo culture and it may also help to explain the controversy in the literature regarding the production of PAF by embryos. PAF also alters several aspects of maternal physiology during early pregnancy including endometrial prostaglandin secretion. The significance of these changes remains to be defined.
O'Neill
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Department of Physiology, University of Sydney, Royal North Shore Hospital of Sydney, St. Leonards, NSW, Australia.
D000818:Animals; D004622:Embryo, Mammalian / Q000187:drug effects / Q000502:physiology*; D004625:Embryo, Nonmammalian; D005260:Female; D008431:Maternal-Fetal Exchange; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000502:physiology*; D011247:Pregnancy; D014599:Uterus / Q000502:physiology
D010972:Platelet Activating Factor