Origin of luteinizing hormone-releasing hormone (LHRH) neurons in the chick embryo: effect of the olfactory placode ablation.
A unilateral olfactory placodectomy resulted in the absence of luteinizing hormone-releasing hormone-immunoreactive (LHRH-ir) cells in the olfactory-forebrain axis of the operated side, whereas the development of the LHRH neuronal system was not disturbed on the unoperated side. In the embryos in which a fragment of the medial olfactory epithelium was spared the damage, a small number of LHRH-ir cells were detected in the nasal region of the operated side, where the lack of the central projection of the olfactory nerve caused stagnation of LHRH-ir cells, no ir-cells being found in the brain area. These results suggest that LHRH neurons originate in the olfactory placode and then migrate into the forebrain along the olfactory nerve.
Akutsu
S
S
Department of Obstetrics and Gynecology, Juntendo University School of Medicine, Tokyo, Japan.
Takada
M
M
Ohki-Hamazaki
H
H
Murakami
S
S
Arai
Y
Y
D000818:Animals; D002642:Chick Embryo; D007987:Gonadotropin-Releasing Hormone / Q000502:physiology*; D007150:Immunohistochemistry; D009474:Neurons / Q000502:physiology*; D009830:Olfactory Bulb / Q000196:embryology* / Q000502:physiology; D016548:Prosencephalon / Q000166:cytology / Q000196:embryology
D007987:Gonadotropin-Releasing Hormone