The ATP-dependent glutathione S-conjugate export pump.
The ATP-dependent glutathione S-conjugate export pump (GS-X pump) plays a physiologically important role as a member of the 'phase III' system in xenobiotic metabolism as well as in the release of biologically active endogenous substances from cells. In addition, this export pump is potentially involved in the modulation of the antiproliferative action of certain antitumor agents.
Ishikawa
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Department of Experimental Pediatrics, University of Texas M.D. Anderson Cancer Center, Houston 77030.
D000255:Adenosine Triphosphate / Q000502:physiology*; D000818:Animals; D001693:Biological Transport, Active; D002455:Cell Division; D002462:Cell Membrane / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000473:pathology; D015262:Xenobiotics / Q000378:metabolism
D015262:Xenobiotics; D000255:Adenosine Triphosphate; D005978:Glutathione