[Effect of ethyl alcohol on selected parameters of the hemostasis system in vitro].
Alcohol produces several disorders in all components of hemostasis system. However, its mechanism of action is not clear. Therefore, an effect of ethyl alcohol on the selected parameters of both platelet and plasma hemostasis has been examined in vitro. Blood aggregation induced by ADP and PAF and platelet-leucocytic aggregates have been determined in vitro in the group of 45 healthy volunteers. Out of plasma parameters the selected factors of blood coagulation and fibrinolysis have been examined. Results suggest that the examined concentrations of ethyl alcohol mainly affect platelet function decreasing platelet aggregation. Alcohol does not affect significantly blood coagulation and fibrinolysis occurring in vitro.
Giedrojć
J
J
Kliniki Hematologii AM, Białymstoku.
Bodzenta-Lukaszyk
A
A
Kłuczko
J
J
Galar
M
M
Bielawiec
M
M
D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects* / Q000502:physiology; D001780:Blood Coagulation Tests; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008954:Models, Biological; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D010979:Platelet Function Tests
D010975:Platelet Aggregation Inhibitors; D000431:Ethanol
Ocena wpływu alkoholu etylowego na wybrane parametry układu hemostazy in vitro.