title: A continuing signal maintains NGF receptor expression in hypoglossal motor neurons after crush injury.
abstract: Inhibition of axonal transport by vincristine applied to hypoglossal nerves 7 days after crush injury turns off the usual injured-induced expression of low affinity nerve growth factor receptor (p75NGFr). Vincristine applied proximal but not distal to the crush prevents p75NGFr induction. These results indicate that a continuing signal is axonally transported from the crush site that induces and maintains p75NGFr expression by injured motor neurons.
authors.affiliation: Neurology Department, DVAMC, Nashville, TN 37212-2637.
authors.forename: D M
authors.initials: DM
authors.lastname: Greeson
authors.forename: L
authors.initials: L
authors.lastname: Moix
authors.forename: M
authors.initials: M
authors.lastname: Meier
authors.forename: D M
authors.initials: DM
authors.lastname: Armstrong
authors.forename: R G
authors.initials: RG
authors.lastname: Wiley
mesh_terms: D000818:Animals; D007002:Hypoglossal Nerve / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009046:Motor Neurons / Q000187:drug effects / Q000378:metabolism*; D009409:Nerve Crush; D051381:Rats; D017207:Rats, Sprague-Dawley; D017475:Receptors, Nerve Growth Factor / Q000187:drug effects / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D014750:Vincristine / Q000494:pharmacology
chemical_list: D017475:Receptors, Nerve Growth Factor; D014750:Vincristine