Cornea epithelial damage thresholds in rabbits exposed to Tm:YAG laser radiation at 2.02 microns.
We have determined exposure conditions for minimal damage to the corneal epithelium in rabbit using a continuous wave Tm: YAG laser operating in the TEM00 mode at incident powers between 80 and 450 mW. The 1/e beam diameter was 0.94 mm and exposure durations for threshold damage ranged from 4.3 to 0.08 sec. Calculated temperature increases on the beam axis 10 microns beneath the surface at the measured thresholds were essentially constant and averaged 44 degrees C. This is basically the same temperature increase found for threshold CO2 laser damage and suggests that the critical temperature damage model, which correlates CO2 laser damage, can predict damage thresholds for mid-infrared laser radiation. We also showed that reliable thresholds can be determined in freshly enucleated eyes, thus opening up the possibility of using available laser sources in laboratories not equipped and approved for animal experiments to determine damage thresholds.
McCally
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RL
Milton S. Eisenhower Research Center, Johns Hopkins University Applied Physics Laboratory, Laurel, Maryland 20723.
Farrell
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RA
Bargeron
C B
CB
D000818:Animals; D003315:Cornea / Q000473:pathology / Q000528:radiation effects*; D065306:Corneal Injuries; D004728:Endothelium, Corneal / Q000293:injuries / Q000473:pathology / Q000528:radiation effects; D006358:Hot Temperature; D007834:Lasers / Q000009:adverse effects*; D011817:Rabbits