[Monoclonal antibodies to neuron-specific enolase in phenotyping lung cancer].
Morphological assessment of two samples of monoclonal antibodies (mcAB) to gamma-unit of neurospecific human enolase (NSE) is performed. It is established that mcABs interact in the tissue sections with neurons of the brain and spinal cord, gangliocytes of the central and peripheral nervous system this proving their specificity. 56 cases of lung carcinoma are studied using these mcABs; endocrine carcinoma was found in 11 cases, nonendocrine--in 45 cases. Neuroendocrine differentiation is revealed in 8 of 45 cases of non-small cell carcinoma; in all observations of small cell carcinoma NSE was found.
Frank
G A
GA
Kazesalu
Ia S-V
IaS
Piĭrsoo
A O
AO
Litvinova
L V
LV
Vial'tsev
N V
NV
D000911:Antibodies, Monoclonal; D000918:Antibody Specificity / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology* / Q000473:pathology; D009490:Neurosecretory Systems / Q000276:immunology; D010641:Phenotype; D010751:Phosphopyruvate Hydratase / Q000032:analysis*
D000911:Antibodies, Monoclonal; D010751:Phosphopyruvate Hydratase
Monoklonal'nye antitela k neĭronspetsificheskoĭ énolaze v fenotipirovanii raka legkogo.