The kallikrein-kinin system in early state of diabetes.
The kallikrein-kinin system was studied in 9 normals, healthy subjects (6 men, 3 women, age range 1 to 14 years) and 15 diabetic patients (9 men, 6 women age range 2 to 14 years) with an evolution of the disease between 1 to 14 years. Diabetic patients with low microalbuminuria (6.62 +/- 0.97 mg/24 h) show increased total and pre-kallikrein respect to control (3 and 2 fold respectively). On the other hand patients with high microalbuminuria (44.7 +/- 13.2 mg/24 h) show a total and pre-kallikrein of more than 4 and 8 fold increased respectively, compare with the control. According with these results we can concluded: 1) The total kallikrein and pre-kallikrein is increased in the diabetic state. 2) When microalbuminuria is high, the total and pre-kallikrein correlates with those increasing. 3) These changes could modified the renal hemodynamic in diabetes.
Vila
S B
SB
Cátedra de Fisiología, Facultad de Farmacia y Bioquímica, Hospital General de Niños Dr. Pedro Elizalde, Buenos Aires, Argentina.
Peluffo
V A
VA
Alvarado
C
C
Cresto
J C
JC
Zuccollo
A
A
Catanzaro
O L
OL
D000293:Adolescent; D000419:Albuminuria; D002648:Child; D002675:Child, Preschool; D003920:Diabetes Mellitus / Q000201:enzymology / Q000503:physiopathology / Q000652:urine*; D005260:Female; D005919:Glomerular Filtration Rate; D006029:Glycosuria; D006801:Humans; D007223:Infant; D007610:Kallikreins / Q000652:urine*; D008297:Male; D011288:Prekallikrein / Q000652:urine; D012016:Reference Values
D011288:Prekallikrein; D007610:Kallikreins