Increased volume of gastric contents in diabetic patients undergoing renal transplantation: lack of effect with cisapride.
Gastroparesis is a frequently unrecognized complication of insulin-dependent diabetes mellitus, which subjects these patients to the risk of aspiration at induction of anaesthesia. The effect of oral cisapride on volume and pH of gastric contents was studied in 24 diabetic and 24 non-diabetic uraemic patients undergoing renal transplantation. All patients were allocated randomly in a double-blind fashion to receive either 10 mg of cisapride or placebo orally approximately 100 min before anaesthesia and three times daily for the first 2 postoperative days. After the induction of anaesthesia, gastric contents were aspirated through a nasogastric tube, and the pH and volume were measured. The emptiness of the stomach was verified by gastroscopy. Gastric volumes exceeding 0.4 ml.kg-1 were observed in 12/24 of the diabetic and 4/24 of the non-diabetic uraemic patients (P < 0.01). The pH of the gastric contents did not differ between the groups, ranging from 1-8 in diabetics and 1-7 in non-diabetics. Cisapride lacked effect on gastric contents and postoperative gastrointestinal motility. Diabetic uraemic patients had larger gastric volumes than their non-diabetic controls at induction of anaesthesia. Cisapride had no effect on gastric emptying preoperatively nor on postoperative bowel function.
Reissell
E
E
Department of Anaesthesia, Helsinki University Central Hospital, Finland.
Taskinen
M R
MR
Orko
R
R
Lindgren
L
L
D000284:Administration, Oral; D000328:Adult; D000768:Anesthesia, General; D020117:Cisapride; D003672:Defecation / Q000187:drug effects; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology / Q000601:surgery*; D004311:Double-Blind Method; D005745:Gastric Acidity Determination; D005746:Gastric Emptying / Q000187:drug effects; D005766:Gastrointestinal Contents / Q000187:drug effects*; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D006863:Hydrogen-Ion Concentration; D016030:Kidney Transplantation; D010880:Piperidines / Q000008:administration & dosage / Q000627:therapeutic use*; D010919:Placebos; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D014511:Uremia / Q000503:physiopathology / Q000601:surgery
D010880:Piperidines; D010919:Placebos; D012702:Serotonin Antagonists; D020117:Cisapride