Artificial cells in immobilization biotechnology.
Artificial cells contain biologically active materials. Artificial cells containing adsorbents have been a routine form of treatment in hemoperfusion for patients. This includes acute poisoning, high blood aluminum and iron, and supplement to dialysis in kidney failure. Artificial cells are being tested for use as red blood cell substitutes. Artificial cells encapsulated cell culture are being tested in animals for the treatment of diabetes and liver failure. A novel 2 step method has prevented xenograft rejection. Artificial cells containing enzymes are being studied for treatment in hereditary enzyme deficiency diseases and other diseases. Recent demonstration of extensive enterorecirculation of amino acids in the intestine has allowed its oral administration to deplete specific amino acids. Artificial cells containing complex enzyme system convert wastes like urea and ammonia into essential amino acids. Artificial cell is being used for the production of monoclonal antibodies, interferons and other biotechnological products. It is also being investigated for drug delivery, and for use in other applications in biotechnology, chemical engineering and medicine.
Chang
T M
TM
Artificial Cells & Organs Research Centre, Faculty of Medicine, McGill University, Montreal, P.Q., Canada.
D001672:Biocompatible Materials; D001802:Blood Substitutes; D002477:Cells / Q000737:chemistry*; D008567:Membranes, Artificial
D001672:Biocompatible Materials; D001802:Blood Substitutes; D008567:Membranes, Artificial