title: Abnormalities of chromosome 22 in meningiomas and confirmation of the origin of a dicentric 22 by in situ hybridization.
abstract: We report three cases of meningioma. Case 1 had a dicentric chromosome number 22 resulting in partial monosomy for a portion of the q-arm, i.e., 46,XX,idic(22)(pter-->q11.2::q11.2-->pter) and 46,XX,psu dic(22)(pter-->q11.2::q11.2-->pter), which was the sole clonal abnormality. The origin of the dicentric chromosome from 22 was confirmed by in situ hybridization studies, using biotin-labeled alpha centromeric DNA probes for the acrocentric chromosomes. Case 2 had two distinct clonal abnormalities: deletion of 22q and monosomy of 22. Case 3 also had a deleted 22q.
authors.affiliation: Center for Human Genetics, Boston University School of Medicine, MA 02118.
authors.forename: V
authors.initials: V
authors.lastname: Tonk
authors.forename: P
authors.initials: P
authors.lastname: Osella
authors.forename: A
authors.initials: A
authors.lastname: Delasmorenas
authors.forename: H E
authors.initials: HE
authors.lastname: Wyandt
authors.forename: A
authors.initials: A
authors.lastname: Milunsky
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000235:genetics; D002503:Centromere; D002872:Chromosome Deletion; D002892:Chromosomes, Human, Pair 22; D015342:DNA Probes; D005260:Female; D006258:Head and Neck Neoplasms / Q000235:genetics; D006801:Humans; D017403:In Situ Hybridization; D007621:Karyotyping; D008579:Meningioma / Q000235:genetics*; D008875:Middle Aged; D009006:Monosomy; D013120:Spinal Cord Neoplasms / Q000235:genetics
chemical_list: D015342:DNA Probes