[Edema in acute diffuse glomerulonephritis, rheumatic peliosis and epidemic parotitis].
The Authors present a substantial series of infant APING in which the venous blood gas analysis shows poor use of oxygen, due to a probably reduced cellular combustion associated with low pCO2, high pH, which are characteristic of arterial blood travelling through anastomotic paths and preferential channels at the microcirculation level. They emphasize the contemporaneous increase in volemia, even with oedema present, and the poor permeation of the capillary wall found with the Landis test, contrary to what happens in glomerulonephrosis with minimal changes which features increased systematic capillary permeation with hypovolemia. The look of the oedema, together with the hypervolemia, led to the suspicion that the nephritic oedema was a sign of mainly intracellular oedema. In the opinion of the Authors these nephritic forms would seem to show systemic cellular respiratory suffering sensitive to the action of chlorpromazine, which has also dealt swiftly and cleanly with the oligoanuresis. The Authors consider 52 cases of Schöenlein-Henoch vasculitis which showed very rapid detumescence of periarticular swelling and those on the back of the hands and feet, as well as the disappearance of skin petechias and melena following treatment with chlorpromazine. They also mention two cases of Kawasaki's disease which seemed to react favorably to the combination of the action of chlorprmazine with acetylsalicylic acid. The effects obtained with chlorpromazine in 27 cases of epidemic parotitis with periscialoadenitis elastic tumescence are reported, with the focus on the reduction of the perisalivary tumescence. It is important to point out the very rapid disappearance of epigastrial pain, probably pancreatic in origin.(ABSTRACT TRUNCATED AT 250 WORDS)
Malossi
M
M
U.O. Pediatria IIa, Ospedale di Trento, Italia.
Malossi
R
R
D000208:Acute Disease; D001241:Aspirin / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D002746:Chlorpromazine / Q000008:administration & dosage / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D004487:Edema / Q000209:etiology*; D005921:Glomerulonephritis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D007223:Infant; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications / Q000188:drug therapy; D009107:Mumps / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
D001241:Aspirin; D002746:Chlorpromazine
L'edema nella glomerulonefrite acuta diffusa, nella peliosi reumatica e nella parotite epidemica.