The effect of halothane on cultured fibroblasts and neuroblastoma cells.
Halothane exposure over the cultured cells (100 and 1,000 ppm) caused a disruption of the pattern of actin distribution in both fibroblasts and neuroblastoma cells. Neuroblastoma cells exposed to halothane also lost microspikes; however, neurite elongation was not affected by halothane. The present study suggests that halothane induces the functional disruption of actin, resulting in an interference of normal neural development in vivo.
Uemura
E
E
Department of Anatomy, Iowa State University, Ames 50011.
Levin
E D
ED
D000199:Actins / Q000096:biosynthesis; D000818:Animals; D002478:Cells, Cultured; D005260:Female; D005347:Fibroblasts; D006221:Halothane / Q000494:pharmacology*; D051379:Mice; D008870:Microtubules / Q000187:drug effects; D009423:Nervous System Neoplasms / Q000378:metabolism*; D009447:Neuroblastoma / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D014407:Tumor Cells, Cultured
D000199:Actins; D006221:Halothane