title: [Mechanism of cytokine pleiotropy and mutual regulation].
abstract: Cytokines manifest overlapping effects on many cell types and their production is regulated by a cytokine network. This minireview summarizes the current understanding of how affinity converter molecules, shared by several cytokines, is related to cytokine pleiotropy, and how Th1/Th2 are differentially developed and regulated through a cytokine network, especially, negative loop. Finally, the importance of the temporal expression of cytokines, in relation to the physiological relevance of the network, is pointed out.
authors.affiliation: Dept. of Biomolecular Science, Faculty of Science, Toho University.
authors.forename: Y
authors.initials: Y
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D016207:Cytokines / Q000502:physiology*; D006801:Humans
chemical_list: D016207:Cytokines