Nasal memory T lymphocytes capable of producing IL-4 in the allergic reaction.
This paper reports the presence of memory T cells in the nasal mucosa of allergic patients. The demonstration of CD4+/CD29+ (CD4+/CD45RO+) T lymphocytes, which are capable of interleukin-4 production, can indicate a complementary cell-mediated regulatory mechanism for mast cell proliferation and IgE synthesis in human nasal allergy. No substantial IgE production can be obtained in the absence of IL-4. Therefore, the existence of IL-4 producing cells on site in the nasal mucosa of allergic subjects probably implies a complementary interaction between cytokines and different immunocompetent nasal cells in the regulation of B cells and IgE synthesis.
Hellquist
H B
HB
Department of Pathology, Orebro Medical Center Hospital, Sweden.
Karlsson
M G
MG
D016207:Cytokines / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007073:Immunoglobulin E / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis*; D009297:Nasal Mucosa / Q000276:immunology*; D009299:Nasal Provocation Tests; D013601:T-Lymphocytes / Q000276:immunology*
D016207:Cytokines; D015847:Interleukin-4; D007073:Immunoglobulin E