Determination of zopiclone in plasma using column liquid chromatography with ultraviolet detection.
A reversed-phase liquid chromatographic method with ultraviolet detection for the determination of zopiclone in plasma is described. It is rapid, sensitive, reproducible and linear over a wide range. The method was used to study plasma zopiclone concentrations in a case of acute intoxication after oral ingestion of 300 mg of the drug. The plasma level was 1600 ng/ml 4.5 h after the dose and the elimination half-life was 3.5 h.
Royer-Morrot
M J
MJ
Service de Pharmacologie Clinique et Toxicologie, Hopital Central, Nancy, France.
Rambourg
M
M
Jacob
I
I
Bauer
P
P
Royer
R J
RJ
D000328:Adult; D053961:Azabicyclo Compounds; D002853:Chromatography, Liquid / Q000379:methods*; D006801:Humans; D008297:Male; D010879:Piperazines / Q000097:blood* / Q000506:poisoning; D015203:Reproducibility of Results; D013056:Spectrophotometry, Ultraviolet; D013406:Suicide, Attempted
D053961:Azabicyclo Compounds; D010879:Piperazines; C515050:zopiclone