title: Urinary protein excretion induced by exercise: effect of a mountain agonistic footrace in healthy subjects. Renal function and mountain footrace.
abstract: The increase in albuminuria induced by exercise in healthy subjects is variably dependent on an increased glomerular filtration and/or to a decreased tubular reabsorption of albumin, in relation to the intensity of muscular work. Membrane anionic charges and haemodynamic changes have been implicated in exercise-induced albuminuria. We evaluated in 12 healthy subjects albumin and beta-2-microglobulin excretion rate and the presence in urine of cationic compounds before and after an agonistic mountain footrace. Albumin excretion rate increased significantly (3.7 +/- 1.3 vs 43.7 +/- 10.0 micrograms/min) (p less than 0.001) and beta-2-microglobulin excretion rate (16.5 +/- 4.4 vs 37.9 +/- 7.4 micrograms/min) (p less than 0.025), too. In 3/4 subjects, urines revealed a peak of highly cationic proteins, sharing antigenic and biological characteristics with platelet-derived cationic proteins. The increase in albuminuria induced by strenuous exercise of an agonistic mountain footrace is of mixed type (both glomerular and tubular) and is associated to the urinary excretion of cationic proteins.
authors.affiliation: Institute of Internal Medicine, University of Turin, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Estivi
authors.forename: R
authors.initials: R
authors.lastname: Urbino
authors.forename: C
authors.initials: C
authors.lastname: Tetta
authors.forename: G
authors.initials: G
authors.lastname: Pagano
authors.forename: P
authors.initials: P
authors.lastname: Cavallo-Perin
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000209:etiology; D002412:Cations / Q000652:urine; D003163:Competitive Behavior / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000502:physiology*; D008297:Male; D010807:Physical Endurance / Q000502:physiology*; D011507:Proteinuria / Q000209:etiology*; D012420:Running; D001613:beta 2-Microglobulin / Q000652:urine
chemical_list: D002412:Cations; D001613:beta 2-Microglobulin