title: Design of intramedullary prostheses to prevent bone loss: predictions based on damage-stimulated remodelling.
abstract: The adaptation of bone around intramedullary fixated prostheses, such as the femoral component of the hip joint or the radial component of the elbow joint, is well documented in follow-up studies. Bone adaptation takes the form of proximal bone atrophy accompanied, in some cases, by distal bone hypertrophy. A mechanistic model has been formulated to predict bone adaptation based on the concept that the continuous processes of damage and repair regulate bone adaptation. We apply the model to investigate the significance of two features of intramedullary prosthesis design on bone adaptation: prosthesis Young's modulus and the presence of a prosthesis collar. Results, as well, as indicating some characteristics of accumulative-damage stimulated bone adaptation, predict that a low Young's modules stem will very much reduce the extent of bone loss whereas the presence of a collar will have no significant effect. The results predict that a collarless low stiffness prosthesis is one possible approach for improving the secondary stability of intramedullary-fixated orthopaedic implants.
authors.affiliation: Bioengineering Research Centre, Trinity College, Dublin, Ireland.
authors.forename: P J
authors.initials: PJ
authors.lastname: Prendergast
authors.forename: D
authors.initials: D
authors.lastname: Taylor
mesh_terms: D000222:Adaptation, Physiological; D016723:Bone Remodeling; D001862:Bone Resorption / Q000517:prevention & control*; D001842:Bone and Bones / Q000502:physiology; D006801:Humans; D007595:Joint Prosthesis; D008433:Mathematics; D008954:Models, Biological; D011379:Prognosis; D011474:Prosthesis Design; D013314:Stress, Mechanical