Activities of newer fluoroquinolones against Shigella sonnei.
The activities of six fluoroquinolones were determined for 117 separate strains of Shigella sonnei. The order of increasing activity (MICs for 90% of strains tested) was enoxacin (0.25 micrograms/ml), temafloxacin (0.032 micrograms/ml), sparfloxacin (0.016 micrograms/ml), CI-960 (0.008 micrograms/ml), ciprofloxacin (0.008 micrograms/ml), and PD-131628-2 (0.008 micrograms/ml). These data, along with results of killing and mutational rate studies, showed that all six fluoroquinolones were highly inhibitory against S. sonnei and five fluoroquinolones were rapidly and persistently bactericidal.
John
J F
JF
Infectious Diseases Division, Medical University of South Carolina, Charleston 29425.
Atkins
L T
LT
Maple
P A
PA
Bratoeva
M
M
D000890:Anti-Infective Agents / Q000494:pharmacology*; D024841:Fluoroquinolones; D008826:Microbial Sensitivity Tests; D012764:Shigella sonnei / Q000187:drug effects*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones