The kallikrein-kinin system of sweat in normal and cystic fibrosis subjects.
The mechanisms of kallikrein secretion was studied in 25 normal subjects (11 male, 14 female) and 5 subjects with cystic fibrosis (identified by the usual criteria). The results obtained show a decreasing of prekallikrein and total kallikrein in cystic fibrosis stimulated by IPR or pilocarpine compare to controls. On the other hand sweat from males shows more prekallikrein and total kallikrein than females. According with this results we can concluded that the basic defect in sweat cystic fibrosis gland could be the possible involvement of the kallikrein-kinin system on the high osmolality of the sweat secretion.
Zucollo
A
A
Cátedra de Fisiología y Programa de Péptidos, Facultad de Farmacia y Bioquímica, UBA, Argentina.
Martiarena
J
J
Luna
C
C
Pivetta
O
O
Villagra
A
A
Catanzaro
O
O
D002648:Child; D003550:Cystic Fibrosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D007610:Kallikreins / Q000378:metabolism*; D008297:Male; D010862:Pilocarpine / Q000494:pharmacology; D011288:Prekallikrein / Q000378:metabolism*; D012016:Reference Values; D013542:Sweat / Q000187:drug effects / Q000378:metabolism*
D010862:Pilocarpine; D011288:Prekallikrein; D007610:Kallikreins; D007545:Isoproterenol