title: Determining the time of the urinary luteinizing hormone surge. Does it facilitate the interpretation of endometrial biopsy results?
abstract: Recent data suggest that endometrial maturation correlates highly with the postovulatory day as determined by ultrasound or identification of the urinary luteinizing hormone (LH) surge. A study was performed to determine the level of correlation between two methods of endometrial biopsy (EB) interpretation. Method 1 correlated histology with the onset of the next menstrual period; method 2 correlated it with the postovulatory day relative to the LH surge. Forty EBs were analyzed. Both methods agreed that 20/40 EBs were in phase and 6/40 EBs were out of phase (greater than a two-day lag between histologic endometrial maturation and chronologic dating). Of the remaining 14 EBs, 8 were in phase by method 1 and out of phase by method 2, and 6 were out of phase by method 1 and in phase by method 2. Thus, 35% of EBs were considered in phase by one method and out of phase by the alternative method. This implies that 35% of management decisions regarding whether to repeat an EB or treat an out-of-phase EB may be influenced by the method of interpreting EBs.
authors.affiliation: Department of Obstetrics and Gynecology, Sinai Hospital of Baltimore, Maryland 21215.
authors.forename: S
authors.initials: S
authors.lastname: Smith
mesh_terms: D001706:Biopsy; D004717:Endometrium / Q000473:pathology*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000473:pathology / Q000503:physiopathology* / Q000652:urine; D008183:Luteal Phase / Q000502:physiology*; D007986:Luteinizing Hormone / Q000652:urine*; D013223:Statistics as Topic; D013997:Time Factors
chemical_list: D007986:Luteinizing Hormone