title: Septic arthritis in 15 standardbred racehorses after intra-articular injection.
abstract: Case histories, results of synovial fluid analyses, treatment regimens and outcome are described for 15 adult Standardbred horses with confirmed post-injection septic arthritis. Joint sepsis followed injection of corticosteroids, hyaluronic acid, polysulphated glycosaminoglycan, or local anaesthetic. The median interval from injection to appearance of clinical signs was 2.5 days, and median interval from injection to referral was 9 days. The median initial synovial leucocyte count on admission was 57 x 10(9)/litre, but there was a wide range of values (18-258 x 10(9)/litre). The median synovial neutrophil percentage was 95% (77-99%). All bacterial isolates were Gram-positive cocci, 86% of which were staphylococci. All treated horses (12/15) initially received broad-spectrum parenteral antibiotic therapy, and the articulations of all horses except one were lavaged, either with non-surgical through-and-through techniques only (N = 3), or surgically with arthrotomy (N = 1) or arthroscopy (N = 7). The owners of all treated horses were contacted and racing records were consulted. Eleven of 12 horses returned to racing. Outcome was judged as either satisfactory (3/12) if the horse had returned to racing levels similar to or better than before treatment, or unsatisfactory (9/12) if the horse had poorer performance or could not return to racing. The 3 horses with satisfactory follow-up had been treated with arthroscopy and post-surgical closed suction drainage. The results of bacterial cultures suggest that the initial antimicrobial agents used should be effective against penicillin-resistant staphylococci.
authors.affiliation: Département de Médecine, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Québec, Canada.
authors.forename: J M
authors.initials: JM
authors.lastname: Lapointe
authors.forename: S
authors.initials: S
authors.lastname: Laverty
authors.forename: J P
authors.initials: JP
authors.lastname: Lavoie
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001170:Arthritis, Infectious / Q000175:diagnosis / Q000209:etiology / Q000628:therapy / Q000662:veterinary*; D001182:Arthroscopy / Q000662:veterinary; D003646:Debridement / Q000662:veterinary; D004322:Drainage / Q000662:veterinary; D005260:Female; D006734:Horse Diseases / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006736:Horses; D007270:Injections, Intra-Articular / Q000009:adverse effects / Q000662:veterinary; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D013210:Staphylococcus / Q000302:isolation & purification; D013291:Streptococcus / Q000302:isolation & purification; D013582:Synovial Fluid / Q000737:chemistry* / Q000382:microbiology; D007507:Therapeutic Irrigation / Q000662:veterinary; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents