Effects of diclofenac on ceftriaxone pharmacokinetics in humans.
The effects of diclofenac, a nonsteroidal antiinflammatory drug, on the biliary and urinary excretion of ceftriaxone were evaluated in subjects with a T drain in the common bile duct. The kinetic study was carried out on the sixth postoperative day of treatment with ceftriaxone alone (2 g intravenously; group 1) or ceftriaxone combined with diclofenac (50 mg every 12 h orally from postoperative days 3 to 6; group 2). A significant increase in the elimination half-life of ceftriaxone was observed in group 2 patients. Diclofenac caused a significant rise in ceftriaxone biliary excretion. This increase was not sufficient to balance the significant deficit of urinary excretion of ceftriaxone.
Merle-Melet
M
M
Infectious Diseases Department, Centre Hospitalier Universitaire Nancy-Brabois, Vandoeuvre les Nancy, France.
Bresler
L
L
Lokiec
F
F
Dopff
C
C
Boissel
P
P
Dureux
J B
JB
D000368:Aged; D001646:Bile / Q000187:drug effects; D002443:Ceftriaxone / Q000493:pharmacokinetics* / Q000652:urine; D002763:Cholecystectomy; D002851:Chromatography, High Pressure Liquid; D004008:Diclofenac / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period
D004008:Diclofenac; D002443:Ceftriaxone