title: Malignant lymphoma of the ocular adnexa associated with the benign lymphoepithelial lesion of the parotid glands. Report of two cases.
abstract: BACKGROUND
  The benign lymphoepithelial lesion of the salivary/lacrimal glands is generally regarded as a lymphoproliferative disorder that may be associated with Sjögren syndrome. Although lymphomatous transformation in patients with Sjögren syndrome is well documented, few reports have appeared describing similar findings in patients with a benign lymphoepithelial lesion.
  
  
  METHODS
  The authors report the unusual occurrence of malignant lymphoma involving the ocular adnexa in two patients with a histopathologically documented benign lymphoepithelial lesion of the parotid glands.
  
  
  RESULTS
  Both patients developed B-cell lymphomas. The eyelid tumor in case 1 expressed IgM/kappa cell surface markers by flow cytometry, and the orbital/conjunctival masses in case 2 showed neoplastic nodules of B cells that were only immunoreactive to lambda light chains (avidin-biotin complex method).
  
  
  CONCLUSIONS
  To the authors' knowledge, this is the first report of ocular adnexal lymphoma arising in patients with a benign lymphoepithelial lesion of the parotid glands. This report establishes that ocular adnexal lymphoma may arise in a patient with a preexisting benign lymphoepithelial lesion.
authors.affiliation: Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, TX 77030.
authors.forename: R L
authors.initials: RL
authors.lastname: Font
authors.forename: R
authors.initials: R
authors.lastname: Laucirica
authors.forename: P S
authors.initials: PS
authors.lastname: Rosenbaum
authors.forename: J R
authors.initials: JR
authors.lastname: Patrinely
authors.forename: M
authors.initials: M
authors.lastname: Boniuk
mesh_terms: D000368:Aged; D003230:Conjunctival Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D005142:Eyelid Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000000981:diagnostic imaging / Q000473:pathology*; D008232:Lymphoproliferative Disorders / Q000473:pathology*; D008297:Male; D009918:Orbital Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D010305:Parotid Diseases / Q000473:pathology*; D014057:Tomography, X-Ray Computed