Development of continuous recirculating peritoneal dialysis using a double lumen catheter.
Continuous recirculating peritoneal dialysis (CRPD) was newly introduced to improve solute removal efficiency in conventional dialysis therapies such as hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD). In CRPD, a part of the dialysate in the peritoneal cavity was drained through a double-lumen catheter and purified by an extracorporeal dialyzer. Urea removal characteristics in CRPD were examined in a canine study. In this study, a recirculation-dialysis experiment using a dog weighing 9.0 kg was carried out under 100 and 200 ml/min of flow for recirculating and delivered dialysates, respectively. An FB-50H (Nipro Medical Industries, Ltd., Osaka, Japan) composed of cellulose diacetate membrane with 0.5 m2 of surface area and Dianeal-1.5 (Baxter Limited Laboratories, Tokyo, Japan) containing urea were used as the extracorporeal dialyzer and dialysate. Urea peritoneal and dialyzer dialysances (DBP and DBD) were 3.05 and 33.3 ml/min by computer simulation using a compartment model for CRPD. This DBP value can be estimated as 20.3 ml/min for a 60 kg human. From this result, time-averaged value for BUN over an 8 hr/day CRPD, combined with three exchanges/day as CAPD is estimated to be 34.3 mg/dl, which is much lower than 45.2 mg/dl for a 12 hr/week HD, or 53.0 mg/dl for conventional CAPD.
Mineshima
M
M
Kidney Center, Tokyo Women's Medical College, Japan.
Watanuki
M
M
Yamagata
K
K
Era
K
K
Nakazato
S
S
Suga
H
H
Agishi
T
T
Ota
K
K
Sakai
K
K
Fukui
K
K
D000818:Animals; D002404:Catheterization / Q000295:instrumentation; D004285:Dogs; D005069:Evaluation Studies as Topic; D007700:Kinetics; D015233:Models, Statistical; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000295:instrumentation* / Q000379:methods; D014508:Urea / Q000378:metabolism
D014508:Urea