[The search for new antiparasitic agents. 11. The acute toxicity and anticestodal activity of the new anthelmintic Tizanox compared with Azinox].
A synthesis is described and the results of toxicological trial of the potential anthelmintic agent G-1587 are presented. The agent is 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-2H-[1, 2,5] thiadiazino [3,2-a] isoquinoline-4,4-dioxide. The agent was shown to have a low toxicity, the maximal sublethal dose for mice being 4.0 g/kg when given per os.
Mikhaĭlitsyn
F S
FS
Kovalenko
F P
FP
Sergovskaia
N L
NL
Lebedeva
M N
MN
Dzhabarova
V I
VI
Lychko
N D
ND
Naĭdenova
A S
AS
D000818:Animals; D000923:Anticestodal Agents / Q000627:therapeutic use / Q000633:toxicity*; D006224:Cricetinae; D004353:Drug Evaluation, Preclinical; D004443:Echinococcosis / Q000188:drug therapy; D005260:Female; D006925:Hymenolepiasis / Q000188:drug therapy; D007546:Isoquinolines / Q000627:therapeutic use / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D008647:Mesocricetus; D051379:Mice; D011223:Praziquantel / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D013829:Thiadiazines / Q000627:therapeutic use / Q000633:toxicity*
D000923:Anticestodal Agents; D007546:Isoquinolines; D013829:Thiadiazines; C078071:azinox; C078109:tizanox; D011223:Praziquantel
Poisk novykh protivoparazitarnykh sredstv. 11. Ostraia toksichnost' i protivotsestodnaia aktivnost' novogo antigel'mintika tizanoksa v sravnenii s azinoksom.