title: Arrest of bacterial DNA replication.
abstract: The chromosomes of both gram-positive and gram-negative bacteria contain sites that arrest the progression of DNA replication forks. These replication-arrest sites limit the end of the replication cycle to a particular region of the chromosome, called the terminus region. Replication arrest is mediated by protein-DNA complexes that show polarity of function: they arrest DNA replication from one direction only. This paper reviews our current knowledge of the replication-arrest complexes of Bacillus subtilis and Escherichia coli and examines possibilities for the function and mechanism of action of these complexes within the bacterial cell.
authors.affiliation: Department of Bioscience and Biotechnology, Drexel University, Philadelphia, Pennsylvania 19104.
authors.forename: T M
authors.initials: TM
authors.lastname: Hill
mesh_terms: D001483:Base Sequence; D004261:DNA Replication; D004269:DNA, Bacterial / Q000096:biosynthesis* / Q000235:genetics*; D008969:Molecular Sequence Data
chemical_list: D004269:DNA, Bacterial