Brucellosis with nephrotic syndrome, nephritis and IgA nephropathy.
A patient with systemic brucellosis due to Brucella melitensis had severe renal involvement. Clinical features included hypertension, macroscopic haematuria, massive proteinuria of 10 g per 24 hours and azotaemia. Following treatment with antibiotics, the azotaemia resolved and proteinuria decreased to less than 0.5 g per 24 hours, but microscopic haematuria and hypertension persisted. Renal biopsy during recovery revealed IgA nephropathy with minimal mesangial changes, suggesting a causal relation between brucellosis and IgA nephropathy with a reversible nephrotic syndrome.
Siegelmann
N
N
Department of Internal Medicine, Shaare Zedek Medical Center, Jerusalem, Israel.
Abraham
A S
AS
Rudensky
B
B
Shemesh
O
O
D000328:Adult; D002006:Brucellosis / Q000150:complications* / Q000188:drug therapy; D004318:Doxycycline / Q000627:therapeutic use; D005260:Female; D005922:Glomerulonephritis, IGA / Q000209:etiology*; D006801:Humans; D009404:Nephrotic Syndrome / Q000188:drug therapy / Q000209:etiology*; D012293:Rifampin / Q000627:therapeutic use
D004318:Doxycycline; D012293:Rifampin