[The clinico-physiological validation of the use of the endolymphatic route for antibiotic administration for preventing the translocation of intestinal microflora during the treatment of sepsis patients].
One of the main mechanisms of generalization of infection in purulent-inflammatory processes of the abdominal cavity, retroperitoneal space and pelvis minor is translocation of the pathogenic microflora of the intestine in the lymphatic system via regional lymphatic nodes with subsequent rupture into the systemic circulation. Endolymphatic administration of antibacterial agents into the peripheral lymphatic vessel favours saturation of the reticuloendothelial structures of the lymph nodes by the antibiotic agent that increases their barrier function and, thus, prevents generalization of the infection and development of polyorganic insufficiency.
Maksimenko
V I
VI
Treshchinskiĭ
A I
AI
Shlapak
I P
IP
Vasil'ev
G A
GA
Bondar'
M V
MV
Kharchenko
L A
LA
Iakub
A A
AA
D000005:Abdomen; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D006801:Humans; D007272:Injections, Intralymphatic; D007422:Intestines / Q000382:microbiology*; D010388:Pelvis; D011645:Puerperal Infection / Q000188:drug therapy / Q000382:microbiology
D000900:Anti-Bacterial Agents
Kliniko-fiziologicheskoe obosnovanie ispol'zovaniia éndolimfaticheskogo puti vvedeniia antibiotikov dlia profilaktiki translokatsii kishechnoĭ mikroflory pri lechenii bol'nykh sepsisom.