title: Serum concentration fluctuation and bioavailability comparison between indomethacin sustained-release and conventional capsules during steady state.
abstract: The comparison between indomethacin conventional capsule (CC) po 25 mg q 8 h or 25 mg tid and indomethacin sustained-release capsule (SRC) po 25 mg bid in human by crossover design showed that both maximal serum concentration (Cmax) and fluctuation index (FI%) of SRC were significantly lower than those of CC during steady state (P < 0.01). No practical differences were observed between the 2 preparations in the trough serum concentration (Cmin) and area under serum concentration-time profiles (AUC0-tau) (P > 0.05). The time period reaching maximal serum concentration (Tmax) of SRC was much more delayed than that of CC (P < 0.01). It suggested that SRC possesses a better controlled release property and could avoid a higher serum peak concentration of CC.
authors.affiliation: Department of Pharmacology, School of Pharmacy, Shanghai Medical University, China.
authors.forename: J P
authors.initials: JP
authors.lastname: Wang
authors.forename: L
authors.initials: L
authors.lastname: Liu
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.forename: X Y
authors.initials: XY
authors.lastname: Yang
authors.forename: D
authors.initials: D
authors.lastname: Li
authors.forename: G Q
authors.initials: GQ
authors.lastname: Ge
authors.forename: Q W
authors.initials: QW
authors.lastname: Huang
mesh_terms: D000328:Adult; D001682:Biological Availability; D002214:Capsules; D003692:Delayed-Action Preparations; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male
chemical_list: D002214:Capsules; D003692:Delayed-Action Preparations; D007213:Indomethacin