[Dependence of mutagenic activity of heterocyclic analogs of pyrene on their chemical structure].
Comparative mutagenic activity of 6 heterocyclic analogs of pyrene was studied. The highest activity was revealed for 2,7-dinitro-4,9-dioxy-5,10-dioxo-4,5,9,10-tetrahydro-4,9- diazapyrene (2,7-DN-DDTDP) and 2,7-dinitro-5,10-dioxo-4,9-dioxapyrene (2,7-DN-DDP) which induced mutations in the tester strain Salmonella typhimurium TA98 and TA100. High mutagenicity of 2,7-DN-DDTDP and 2,7-DN-DDP is conditioned by reduction of nitro groups in the 2,7 position. The carbonyl groups in the 5,10 position were believed to cause bifunctional activity of 2,7-DN-DDTDP and 2,7-DN-DDP and to promote deletion of two G-C in the D3052 site.
Abilev
S K
SK
Liubimova
I K
IK
Migachev
G M
GM
D006571:Heterocyclic Compounds / Q000633:toxicity*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D011721:Pyrenes / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D013329:Structure-Activity Relationship
D006571:Heterocyclic Compounds; D009153:Mutagens; D011721:Pyrenes; C078430:2,7-dinitro-5,10-dioxo-4,9-dioxapyrene; C078429:2,7-dinitro-4,9-dioxy-5,10-dioxo-4,5,9,10-tetrahydro-4,9-diazapyrene
Zavisimost' mutagennoĭ aktivnosti geterotsiklicheskikh analogov pirena ot ikh khimicheskoĭ struktury.