Functional and morphological studies of mitochondria exposed to undecagold clusters: biologic surfaces labeling with gold clusters.
This study reports morphological and functional alterations observed in respiring isolated mitochondria when they are exposed to nonpenetrating, positive electrostatically charged synthetic undecagold clusters. Modification of the undecagold clusters positive charges change or prevent the functional effects and the binding to the outside surface of the mitochondria. The mitochondrial functional alterations are dependent on the oxidative phosphorylation capacity of the isolated organelles. The results of these experiments indicate that artificial undecagold may be useful to explore the molecular mechanisms of biological energy transducers which require electric charges separation, ionic fluxes, and electric surface properties.
Valdivia
E
E
Department of Pathology, University of Wisconsin, Madison 53705-2368.
Gabel
C
C
Reardon
J E
JE
CaJacob
C A
CA
Yang
H
H
Wehbi
R S
RS
Scott
G L
GL
Frey
P A
PA
Fahien
L A
LA
D000818:Animals; D002417:Cattle; D006046:Gold / Q000378:metabolism*; D006321:Heart / Q000502:physiology*; D008854:Microscopy, Electron; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D050607:Organogold Compounds; D009942:Organometallic Compounds / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology*
D050607:Organogold Compounds; D009942:Organometallic Compounds; C035797:undecagold; D006046:Gold