Denervation of dopaminergic neurons with 6-hydroxydopamine increases nerve growth factor content in rat brain.
Denervation of dopaminergic neurons by intra nigral injection of 6-hydroxydopamine (6-OHDA) increased nerve growth factor (NGF) content in the cortex and hippocampus, both of which are innervated by cholinergic neurons. The increase continued during an observation period of 0.5-28 days after the lesion. The time course of changes in NGF content was quite different from that of cholinergic neuron denervation. The decreased dopamine content produced in the striatum by 6-OHDA injection was not recovered during the observation period. These results suggest that dopaminergic neuron damage may affect NGF synthesis.
Nitta
A
A
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, Japan.
Furukawa
Y
Y
Hayashi
K
K
Hiramatsu
M
M
Kameyama
T
T
Hasegawa
T
T
Nabeshima
T
T
D000818:Animals; D001923:Brain Chemistry / Q000502:physiology*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D003714:Denervation; D004298:Dopamine / Q000378:metabolism / Q000502:physiology*; D008297:Male; D009414:Nerve Growth Factors / Q000378:metabolism*; D009474:Neurons / Q000502:physiology*; D016627:Oxidopamine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D009414:Nerve Growth Factors; D016627:Oxidopamine; D004298:Dopamine