Central catecholamine, sympathetic nerve and vascular protein in the acute phase of two-kidney, one-clip renovascular hypertension in rats.
Incorporation of 3H-proline into the non-collagenous protein in mesenteric arteries in two-kidney, one-clip hypertensive rats was greater than that in normotensive rats. Splanchnicotomy predominantly over the root of mesenteric arteries or intracranioventricular injection of 6-hydroxydopamine prevented the development of hypertension in 2K-1C rats concomitant with the reduction of incorporation of 3H-proline into the non-collagenous protein in mesenteric arteries. The content of norepinephrine in the hypothalamus in 2K-1C rats was lower than that in normotensive control rats. These findings indicate that increased non-collagenous protein synthesis in mesenteric arteries or low level of hypothalamic norepinephrine has facilitative effects on the development of 2K-1C hypertension.
Kaneko
H
H
Department of Urology, Yamagata University, School of Medicine, Japan.
Nakada
T
T
D000818:Animals; D001011:Aorta / Q000378:metabolism; D003094:Collagen / Q000378:metabolism; D004549:Elastin / Q000378:metabolism; D006978:Hypertension, Renovascular / Q000503:physiopathology*; D007031:Hypothalamus / Q000737:chemistry; D008297:Male; D008638:Mesenteric Arteries / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000502:physiology*; D011392:Proline / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013564:Sympathetic Nervous System / Q000502:physiology*; D014316:Tritium
D014316:Tritium; D003094:Collagen; D004549:Elastin; D011392:Proline; D009638:Norepinephrine