Time-dependent effect of the angiotensin converting enzyme inhibitor, abutapril, on voluntary alcohol intake in the rat.
The angiotensin converting enzyme (ACE) inhibitor, abutapril (CGS 16617), was administered daily for 3 weeks to six different groups of rats at intervals of 15, 30, 45, 60, 90 or 120 min prior to a 40-min daily access to alcohol. Compared to a control group receiving the saline vehicle, abutapril (20 mg/kg) produced a significant and progressively increasing reduction in alcohol intake over the 3-week period of administration. In addition, intervals around the 60-min mark appeared to produce a more pronounced effect on alcohol intake such that a U-shaped function of interval emerged. These findings indicate that the interval between abutapril administration and alcohol consumption is an important variable in determining the ability of abutapril to reduce alcohol intake. Treatment of human alcohol misuse with ACE inhibitors might be more successful if done on a symptomatic basis.
Grupp
L A
LA
Department of Pharmacology, University of Toronto, Ontario, Canada.
Chow
S Y
SY
D000428:Alcohol Drinking / Q000503:physiopathology*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012084:Renin-Angiotensin System / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
D000806:Angiotensin-Converting Enzyme Inhibitors; D001552:Benzazepines; C052134:libenzapril