[Effect of interferon and interferon combined with 3-methylcholanthrene on the mixed function oxidase system in the liver of mice].
The authors have studied the effect of human interferon alpha alone, as well as its effect when co-administered with 3-methylcholanthrene, on the mixed function oxidase system (MFO) of mouse liver. The single interferon alpha treatment did not influence the activities of MFO. However it decreased significantly the enzyme-inducing effect of 3-methylcholanthrene during combined treatment.
Szabó
I
I
Apáthy István Gyermekkórház-Rendelöintézet, Budapest.
Róna
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K
Renczes
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G
D000818:Animals; D004347:Drug Interactions; D004790:Enzyme Induction / Q000187:drug effects; D016898:Interferon-alpha / Q000494:pharmacology*; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D008862:Microsomes, Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000187:drug effects*
D016898:Interferon-alpha; D008748:Methylcholanthrene; D006899:Mixed Function Oxygenases
Interferon és interferon + 3-metilkolantrén együttes adásának hatása az egérmáj vegyestípusú oxidáz rendszerére.