Effects of bradykinin and Des-Arg9-bradykinin on the ischemic rat heart.
In isolated rat hearts subjected to 30 min stop flow followed by 5 min reperfusion, Bradykinin (Bk), 1 and 0.1 microM, significantly decreased ventricular tachycardia and fibrillation, noradrenaline (NA) output at reperfusion as well as myocardial NA loss and lipid peroxidation, and preserved creatine kinase activity. Des-Arg9-Bk 0.1 microM had also similar effects. Hence, the active metabolite des-Arg9-Bk may be involved in the protective action of Bk, partly mediated by its inhibitory effect on NA liberation.
Chahine
R
R
Research Center, Hôpital du Sacré-Coeur, Montréal, Québec, Canada.
Adam
A
A
Yamaguchi
N
N
Nadeau
R
R
D000818:Animals; D001920:Bradykinin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D017202:Myocardial Ischemia / Q000503:physiopathology*; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013610:Tachycardia / Q000517:prevention & control; D014693:Ventricular Fibrillation / Q000517:prevention & control
C024626:bradykinin, des-Arg(9)-; D008315:Malondialdehyde; D001920:Bradykinin; D009638:Norepinephrine