[Innovative elastomeric bio-adhesive (pup-201) synthesized by urethane-prepolymer].
Properties of PUP-201 for the application to vital organs were estimated. Basic properties of PUP-201 were compared with two kinds of commercial fibrin and synthetic adhesives. Its initial and wet adhesive strength was 40 and 150 times stronger than those of fibrin adhesives respectively. Its curing time was 50 seconds, and elongating rate was 150% nearly as same as that of the intestine. This adhesive had not antimicrobial activities. The strength of adhesive bonded pig skin in shear by tension loading by way of JIS K6850 recorded 2.0-2.7kg/cm2 five minutes after, and 2.0-2.8kg/cm2 after 24 hours. The results of the same test in small intestine defined 0.4-1.0kg/cm2 in sero-sero attachment. There was no toxicity on the pig skin. Practical examinations for application to hemostasis on the section of dog liver and sealing of the lung section were performed successfully. PUP-201 was demonstrated excellently useful material for the adhesive, hemostasis and sealant of vital tissue.
Tani
T
T
First Department of Surgery, Shiga University Medicine Science, Otsu, Japan.
Numa
K
K
Yoshioka
T
T
Yokota
T
T
Araki
H
H
Kodama
M
M
Ito
T
T
D000818:Animals; D004285:Dogs; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use; D051379:Mice; D008813:Mice, Inbred ICR; D011140:Polyurethanes / Q000138:chemical synthesis / Q000627:therapeutic use*; D012408:Rubber / Q000138:chemical synthesis; D013552:Swine; D014014:Tissue Adhesives / Q000138:chemical synthesis
D015718:Fibrin Tissue Adhesive; D011140:Polyurethanes; D014014:Tissue Adhesives; D012408:Rubber