title: Massive perinatal hepatic necrosis from maternal oxytocin overdose.
abstract: Review of clinical records regarding administration of oxytocin may provide clues to the etiology of hepatic infarction in the neonate. The authors present a case in which a large and rapid maternal overdose of oxytocin (17,300 mU over 20 min) during end-stage labor was associated with neonatal death and extensive hepatic infarction. These findings represent novel complications of oxytocin administration.
authors.affiliation: Department of Pathology, Children's Hospital of Pittsburgh, Pennsylvania.
authors.forename: W H
authors.initials: WH
authors.lastname: Robichaux
authors.forename: J A
authors.initials: JA
authors.lastname: Perper
authors.forename: A S
authors.initials: AS
authors.lastname: Knisely
mesh_terms: D000328:Adult; D062787:Drug Overdose; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007238:Infarction / Q000139:chemically induced; D007743:Labor, Obstetric; D007969:Leukomalacia, Periventricular / Q000139:chemically induced; D008099:Liver / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D008431:Maternal-Fetal Exchange; D009336:Necrosis; D010121:Oxytocin / Q000008:administration & dosage / Q000009:adverse effects*; D011247:Pregnancy
chemical_list: D010121:Oxytocin