title: Time course of intraventricular pressure change in a canine model of hydrocephalus: its relationship to sagittal sinus elastance.
abstract: Hydrocephalus was induced in adult greyhounds by intracisternal kaolin. Intraventricular pressure (IVP) was monitored in the conscious animal for 2 weeks using a small implantable sensor, and the time-course of IVP change was characterized. Intraventricular pressure increased significantly within 36 h of kaolin infusion and gradually subsided to normal values within 1 week. Enlargement of the lateral ventricles was not observed during the early phase of intracranial hypertension (less than 2 days). Evolving hydrocephalus and intracranial hypertension increased the elasticity (dP/dV) of the sagittal sinus. This effect was statistically significant (p < 0.05) and is possibly reversible in the acute stage. Normotensive hydrocephalus (1 and 2 weeks after kaolin) was associated with an irreversible increase in resistance to outflow (i.e., increased sagittal sinus elasticity). Sagittal sinus venography of animals with obvious ventricular enlargement (at least 1 week after kaolin) showed development of venous collaterals and atypical outflow pathways.
authors.affiliation: Division of Neurological Surgery, Barrow Neurological Institute, Phoenix, Ariz. 85013.
authors.forename: J M
authors.initials: JM
authors.lastname: McCormick
authors.forename: K
authors.initials: K
authors.lastname: Yamada
authors.forename: H L
authors.initials: HL
authors.lastname: Rekate
authors.forename: H
authors.initials: H
authors.lastname: Miyake
mesh_terms: D000818:Animals; D002552:Cerebral Ventricles / Q000503:physiopathology*; D015170:Cerebrospinal Fluid Pressure / Q000502:physiology*; D002908:Chronic Disease; D003392:Cranial Sinuses / Q000503:physiopathology*; D004195:Disease Models, Animal; D004285:Dogs; D004548:Elasticity; D006849:Hydrocephalus / Q000139:chemically induced / Q000503:physiopathology*; D007427:Intracranial Pressure / Q000502:physiology; D007616:Kaolin; D014690:Venous Pressure / Q000502:physiology
chemical_list: D007616:Kaolin