Lack of pre-C region mutation in woodchuck hepatitis virus from seroconverted woodchucks.
Woodchuck hepatitis virus, which shares a large degree of homology with human HBV, was examined for indications of mutational variants. No alteration in the pre-C region was found, but as in HBV, viral DNA could still be detected by PCR after seroconversion to anti-WHe.
Tong
S P
SP
INSERM U.271, Lyon, France.
Vitvitski
L
L
Li
J S
JS
Pichoud
C
C
Trépo
C
C
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D015613:Hepadnaviridae / Q000235:genetics*; D006513:Hepatitis B e Antigens / Q000235:genetics*; D006524:Hepatitis, Viral, Animal / Q000235:genetics* / Q000276:immunology; D008392:Marmota / Q000382:microbiology*; D016296:Mutagenesis; D016133:Polymerase Chain Reaction; D014758:Viral Core Proteins / Q000235:genetics*
D000914:Antibodies, Viral; D006513:Hepatitis B e Antigens; D014758:Viral Core Proteins