title: Vascular wall kininogen concentration is inversely related to intrinsic kininogenase in spontaneously hypertensive rats.
abstract: We determined kininogen concentration and kininogenase activity in the blood-free, aorta homogenates of 15 week old spontaneously hypertensive rats (SHR) and in their age-matched wistar kyoto (WKY) controls. Active kininogenase in the SHR was only 18% of the WKY controls. Thus, the kininogen concentration was inversely related to kininogenase activity suggesting a local interaction of these components and possible generation of kinins within the vascular wall.
authors.affiliation: Evans Memorial Department of Clinical Research, University Hospital, Boston University School of Medicine, MA 02118.
authors.forename: N B
authors.initials: NB
authors.lastname: Oza
authors.forename: H D
authors.initials: HD
authors.lastname: Goud
mesh_terms: D000818:Animals; D001011:Aorta / Q000378:metabolism*; D001794:Blood Pressure; D066298:In Vitro Techniques; D007610:Kallikreins / Q000378:metabolism*; D007704:Kininogens / Q000378:metabolism*; D007705:Kinins / Q000032:analysis; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D011863:Radioimmunoassay; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
chemical_list: D007704:Kininogens; D007705:Kinins; D007610:Kallikreins