The prevalence of autoantibodies among right and left handed schizophrenic patients and control subjects.
Sera from schizophrenic patients (n = 186) and healthy control subjects (n = 346) were tested for the presence of seven common autoantibodies by standard immunological methods. The association between handedness and autoantibodies was tested in a multi-way contingency table using a log-linear model. For men, but not women, nondextrals (patients and controls) were twice as likely to test positive for autoantibodies than dextrals (p = 0.0002). Although more women (33%) than men (24%) tested positive for autoantibodies, handedness was not a distinguishing factor among women. These data suggest that sinistrality and gender are associated with autoantibodies in a subgroup of schizophrenic patients and healthy control subjects.
Chengappa
K N
KN
Department of Psychiatry (Immunopsychiatry Program), Western Psychiatric Institute & Clinic, University of Pittsburgh, School of Medicine, PA 15213-2593.
Ganguli
R
R
Ulrich
R
R
Rabin
B S
BS
Cochran
J
J
Brar
J S
JS
Yang
Z W
ZW
Deleo
M
M
D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000276:immunology* / Q000523:psychology; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000175:diagnosis / Q000276:immunology*; D012565:Schizophrenic Psychology
D001323:Autoantibodies