Effects of growth hormone on low-density lipoprotein metabolism.
GH appears to play an important role in mediating the increase in hepatic LDL receptor expression that occurs in response to pharmacological oestrogen treatment. Furthermore, in normal individuals there is evidence of an increased number of hepatic LDL receptors in response to GH, resulting in an accelerated elimination rate of the LDL particle and a subsequent lowering of LDL cholesterol. Further studies on lipoprotein metabolism in patients with GH deficiency, and also in patients with hypercholesterolaemia, would therefore be of interest.
Angelin
B
B
Department of Medicine, Karolinska Institute, Huddinge University Hospital, Sweden.
Rudling
M
M
Olivecrona
H
H
Ericsson
S
S
D001693:Biological Transport, Active; D013006:Growth Hormone / Q000502:physiology*; D006801:Humans; D050356:Lipid Metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism*; D011973:Receptors, LDL / Q000502:physiology
D008077:Lipoproteins, LDL; D011973:Receptors, LDL; D013006:Growth Hormone