Atraumatic quantitation of cerebral perfusion in cats by 19F magnetic resonance imaging.
We have noninvasively produced low-resolution, quantitative nuclear magnetic resonance images of cerebral blood flow in 2-ml voxels in eight cats. Typical signal-to-noise of 4 to 1 was obtained in cerebral voxels in 16.5-s epochs. Mean flow during normocapnia (paCO2 = 39 +/- 4 mm Hg) and hypercapnia (paCO2 = 62 +/- 4 mm Hg) was 53 +/- 20 ml/100 g-min and 140 +/- 36 ml/100 g-min, respectively. Fast flows in normocapnia were 94 +/- 13 and 182 +/- 39 ml/100 g-min in hypercapnia. These results suggest that an atraumatic quantitative imaging assessment of cerebral perfusion may be possible in humans using these techniques.
Branch
C A
CA
Department of Neurology, Henry Ford Hospital, Detroit, Michigan 48202.
Ewing
J R
JR
Helpern
J A
JA
Ordidge
R J
RJ
Butt
S
S
Welch
K M
KM
D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D001921:Brain / Q000033:anatomy & histology*; D002415:Cats; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005617:Chlorofluorocarbons, Methane; D005260:Female; D005461:Fluorine; D006935:Hypercapnia / Q000175:diagnosis; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D012815:Signal Processing, Computer-Assisted
D005617:Chlorofluorocarbons, Methane; D005461:Fluorine; C009554:fluoroform