[Effect of 1-year long-term treatment with sucralfate on symptomatic recurrence of duodenal ulcer].
One hundred and two patients, who obtained relief from their duodenal ulcer symptoms with sucralfate (Antepsin R) in a dosage of 2 g b.i.d. for four weeks, were randomized to maintenance therapy with sucralfate 2 g at bedtime or a placebo for one year or until possible recurrence of symptoms. Ninety-four patients completed the study, 46 on sucralfate and 48 on the placebo. Eighteen of the sucralfate-treated patients (39%) experienced relapse of symptoms, as did 36 (75%) of the placebo treated patients. This difference was significant (p = 0.0008). In the sucralfate group most of the symptoms recurred within three months after randomisation, whereas the relapse rate seemed constant in the placebo group. It is concluded that 2 g sucralfate at bedtime is effective in preventing recurrence of duodenal ulcer symptoms.
Larsen
B
B
Medicinsk afdeling, Herning Centralsygehus.
Iversen
T O
TO
Linde
N C
NC
Rahbek
I
I
Pedersen
N T
NT
D000293:Adolescent; D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D004381:Duodenal Ulcer / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D013392:Sucralfate / Q000008:administration & dosage*; D013997:Time Factors
D013392:Sucralfate
Effekt af ét års langtidsbehandling med sukralfat på symptomatisk recidiv af duodenalt ulcus.