Desferrioxamine potentiated SOD antiinflammatory activity in rat adjuvant arthritis: role of iron and bacterial toxins.
In this paper we studied the modulating inflammatory activity of iron in the adjuvant arthritis, taking indomethacin as a standard antiinflammatory drug and a superoxide dismutase derivative (MPEG-SOD) as a scavenger of free radicals. Moreover, we evaluated the changes in potential intestinal pathogens requiring iron for growth, in order to study the role of bacteria in the altered gastrointestinal functions observed during arthritis. We observed a 50% arthritis inhibition on the 14th day with MPEG-SOD plus desferrioxamine, a significant decrease in serum iron in arthritic rats compared to controls, and a significant Cl. perfringens increase on the 28th day in the presence of MPEG-SOD. Our data demonstrate that hypoferremia, in arthritis, is a protective mechanism overall in the early phase and could protect the intestinal tract by inhibiting the development of potential pathogens.
Benoni
G
G
Institute of Pharmacology, University of Verona, Milano, Italy.
Cuzzolin
L
L
Zambreri
D
D
Caramazza
I
I
Del Soldato
P
P
Caliceti
P
P
Conforti
A
A
D000818:Animals; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D003016:Clostridium perfringens / Q000187:drug effects / Q000254:growth & development*; D003676:Deferoxamine / Q000627:therapeutic use*; D004357:Drug Synergism; D005243:Feces / Q000382:microbiology; D016166:Free Radical Scavengers; D007213:Indomethacin / Q000627:therapeutic use; D007501:Iron / Q000097:blood; D008297:Male; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*
D016166:Free Radical Scavengers; D011092:Polyethylene Glycols; D007501:Iron; D013482:Superoxide Dismutase; C078150:monomethoxypolyethylene glycol-superoxide dismutase; D003676:Deferoxamine; D007213:Indomethacin