[Efficacy of the combination of nicardipine-enalapril and atenolol in severe hypertension secondary to chronic renal disease].
The antihypertensive efficacy of combination therapy with N-E-A was evaluated during 6 months in 15 patients with hypertension associated with mild to moderate kidney failure. After 6 months a significant reduction of SBP and DBP (p < 0.001), with improvement of creatinine clearance and with no adverse effects on ECG, heart rate and routine laboratory tests test, was observed in 3 patients treated with N 20 mg x 2/d + E 10 mg/d + A 50 mg/d and in 8 patients treated with N 20 mg x 3 + E 10 mg x 2, + A 50 mg x 2. Four patients did not respond to this therapy.
Melina
D
D
Institut de Pathologie Médicale, Université Catholique du Sacré-Coeur, Rome.
Guerrera
G
G
Santoliquido
A
A
Guerrera
C
C
Musumeci
V
V
Nicolò
G
G
Cataldo
R
R
D000328:Adult; D001262:Atenolol / Q000627:therapeutic use*; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D004656:Enalapril / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006977:Hypertension, Renal / Q000188:drug therapy* / Q000209:etiology; D007674:Kidney Diseases / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009529:Nicardipine / Q000627:therapeutic use*; D016896:Treatment Outcome
D001262:Atenolol; D004656:Enalapril; D009529:Nicardipine
Efficacité de l'association nicardipine-enalapril-aténolol dans l'hta sévère secondaire à une maladie rénale chronique.