title: Venesection in haemoglobin Yakima, a high oxygen affinity haemoglobin.
abstract: High oxygen affinity haemoglobins result in polycythaemia and cardiovascular adaptation to maintain tissue oxygenation. The polycythaemia can cause symptoms of hyperviscosity and vaso-occlusive disease. We report a kindred with a high affinity haemoglobin (Haemoglobin Yakima) one of whose members gave birth to two infants with intra-uterine growth retardation and who suffered with symptoms of hyperviscosity which settled on reduction of the PCV by venesection.
authors.affiliation: Department of Haematology, St. Thomas' Hospital, London, UK.
authors.forename: R J
authors.initials: RJ
authors.lastname: Grace
authors.forename: P A
authors.initials: PA
authors.lastname: Gover
authors.forename: D F
authors.initials: DF
authors.lastname: Treacher
authors.forename: S E
authors.initials: SE
authors.lastname: Heard
authors.forename: T C
authors.initials: TC
authors.lastname: Pearson
mesh_terms: D000293:Adolescent; D001815:Bloodletting; D002318:Cardiovascular Diseases / Q000097:blood / Q000235:genetics*; D005260:Female; D006455:Hemoglobins, Abnormal / Q000378:metabolism*; D006801:Humans; D010100:Oxygen / Q000097:blood*; D010375:Pedigree; D011086:Polycythemia / Q000097:blood / Q000235:genetics* / Q000601:surgery
chemical_list: D006455:Hemoglobins, Abnormal; C078525:hemoglobin Yakima; D010100:Oxygen