Signal transduction and the actin cytoskeleton: the roles of MARCKS and profilin.
MARCKS and profilin, two actin-binding proteins, are discussed to illustrate the mechanism by which extracellular signals are coupled to changes in the structure of the actin cytoskeleton. MARCKS is a filamentous actin-crosslinking protein that appears to function as an integrator of protein kinase C and calcium (Ca2+)/calmodulin signals in the regulation of actin-membrane interactions. New data suggest that profilin is activated by the coordinated action of receptor tyrosine kinases and phospholipase C-gamma 1 to stimulate the stabilization of actin filaments.
Aderem
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Laboratory of Signal Transduction, Rockefeller University, New York, NY 10021.
D000199:Actins / Q000502:physiology*; D000595:Amino Acid Sequence; D000818:Animals; D002118:Calcium / Q000378:metabolism; D003285:Contractile Proteins; D003599:Cytoskeleton / Q000502:physiology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D008840:Microfilament Proteins / Q000502:physiology*; D008969:Molecular Sequence Data; D000076250:Myristoylated Alanine-Rich C Kinase Substrate; D051304:Profilins; D011494:Protein Kinases / Q000378:metabolism; D011506:Proteins / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D000199:Actins; D003285:Contractile Proteins; D047908:Intracellular Signaling Peptides and Proteins; C000619710:MARCKS protein, human; D008565:Membrane Proteins; D008840:Microfilament Proteins; C495738:PFN1 protein, human; D051304:Profilins; D011506:Proteins; D000076250:Myristoylated Alanine-Rich C Kinase Substrate; D011494:Protein Kinases; D002118:Calcium