Alteration of brainstem auditory evoked potentials in diethylbenzene and diacetylbenzene-treated rats.
Male Sprague-Dawley rats were treated either with 1,2-diethylbenzene (1,2-DEB) or its putative active metabolite, 1,2-diacetylbenzene (1,2-DAB). Experimental rats and appropriate controls were examined electrophysiologically for brainstem auditory evoked potentials (BAEP). Oral administration of 1,2-DEB (75 or 100 mg kg-1 once a day, 4 days a week, for 8 weeks) and intraperitoneal injection of 1,2-DAB (10 or 15 mg kg-1 once a day, 4 days a week, for 8 weeks) produced time- and dose-dependent increases in the peak latencies of all BAEP components as well as in interpeak (I-V) differences, and a decrease in the amplitudes of all the components. The absolute and interpeak latencies recovered partially during an 8-week (1,2-DEB) or a 10-week (1,2-DAB) recovery period, whereas there were long-lasting decreases in peak amplitudes.
Gagnaire
F
F
Institut National de Recherche et de Sécurité, Vandoeuvre, France.
Becker
M N
MN
De Ceaurriz
J
J
D000098:Acetophenones / Q000633:toxicity*; D000284:Administration, Oral; D000818:Animals; D001555:Benzene Derivatives / Q000633:toxicity*; D002493:Central Nervous System Diseases / Q000139:chemically induced / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D000098:Acetophenones; D001555:Benzene Derivatives; C064751:1,4-diethylbenzene; C048792:1,2-diacetylbenzene