title: [The enhanced efficacy of the pharmacological regulation of the processes of blood cell activation and interaction in the flow by polymer additives decreasing the hydrodynamic resistance of the blood].
abstract: The increase of blood cell auto- and interactivation and the decrease of aspirin antiaggregant effect were demonstrated under hemodynamic conditions of a stenotic zone in a model maximally approached to the real blood circulation. The lowering of platelet activation, of the release of active agents from platelets, and of platelet-leukocyte interactivation was attained under the conditions of the flow modified by the drag-reducing polymer solution. The recovery of aspirin antiaggregant activity and aspirin-induced reduction of the total platelet release of platelet- and leukocyte-activating agents were demonstrated under the influence of the polymer.
authors.forename: S E
authors.initials: SE
authors.lastname: Akopov
authors.forename: I L
authors.initials: IL
authors.lastname: Konorova
authors.forename: M R
authors.initials: MR
authors.lastname: Grigorian
authors.forename: E S
authors.initials: ES
authors.lastname: Gabrielian
authors.forename: I V
authors.initials: IV
authors.lastname: Gannushkina
mesh_terms: D001241:Aspirin / Q000031:analogs & derivatives / Q000494:pharmacology; D001783:Blood Flow Velocity / Q000187:drug effects*; D001809:Blood Viscosity / Q000187:drug effects*; D002450:Cell Communication / Q000187:drug effects*; D003094:Collagen / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D008239:Lysine / Q000031:analogs & derivatives / Q000494:pharmacology; D008961:Models, Structural; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D015539:Platelet Activation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000494:pharmacology*
chemical_list: D010975:Platelet Aggregation Inhibitors; D011092:Polyethylene Glycols; D009240:N-Formylmethionine Leucyl-Phenylalanine; D003094:Collagen; D008239:Lysine; D001241:Aspirin; C010395:acetylsalicylic acid lysinate
vernacular_title: Povyshenie éffektivnosti farmakologicheskoĭ reguliatsii protsessov aktivatsii i vzaimodeĭstviia kletok krovi v potoke polimernymi dobavkami, snizhaiushchimi gidrodinamicheskoe soprotivlenie krovi.