Antigliadin antibody, D-xylose, and cellobiose/mannitol permeability tests as indicators of mucosal damage in children with coeliac disease.
A dual sugar (cellobiose/mannitol) permeability test using an iso-osmolar solution was performed, to compare its ability to predict small-bowel mucosal damage in children affected by coeliac disease with the determination of serum levels of D-xylose and antigliadin antibody. Eighty-three children (67 on gluten-containing diet and 16 on gluten-free diet) were investigated. The D-xylose and the serum antigliadin antibody test predicted accurately 70% and 78% of the small-bowel biopsy results, respectively, whereas the cellobiose-mannitol permeability test predicted 93%. These data confirm the superiority of the permeability test over the D-xylose test, although the former cannot be advocated as a substitute for jejunal biopsy. Our results suggest a complementary use of the permeability test and the antigliadin antibody measurement as screening tests for coeliac disease before applying more invasive procedures.
Troncone
R
R
Dept. of Pediatrics, University of Naples, Italy.
Starita
A
A
Coletta
S
S
Mayer
M
M
Greco
L
L
D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D002446:Celiac Disease / Q000175:diagnosis* / Q000276:immunology / Q000378:metabolism; D002475:Cellobiose; D002648:Child; D005903:Gliadin / Q000276:immunology*; D006801:Humans; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism; D008353:Mannitol; D012680:Sensitivity and Specificity; D014994:Xylose
D001323:Autoantibodies; D002475:Cellobiose; D008353:Mannitol; D005903:Gliadin; D014994:Xylose