title: Radiographically determined growth dynamics of primary lung tumors induced in dogs by inhalation of plutonium.
abstract: Beagles were exposed to aerosols of 239PuO2, 238PuO2, or 239Pu(NO3)4. Exponential growth constants for 50 primary lung tumors (23 bronchioloalveolar carcinomas, 22 papillary adenocarcinomas, 5 adenosquamous carcinomas) were calculated in 37 dogs, using sequential thoracic radiography. A wide range in doubling time (6 to 287 days) was observed. Mean +/- SEM doubling time was 93 +/- 10 days for bronchioloalveolar carcinoma, 107 +/- 13 days for papillary adenocarcinoma, and 101 +/- 36 days for adenosquamous carcinoma. Lung tumor growth rate in dogs was comparable to that in human patients with similar histologic tumor types. Linear regression analysis revealed significant (P < or = 0.0001) correlation between doubling time and survival of individual dogs. Doubling time was not significantly dependent on tumor type, sex, age at time of diagnosis, initial lung deposition, or isotope. Extrapolating time to tumor onset from tumor doubling time cannot be used to reliably predict the onset of malignancy.
authors.affiliation: Department of Radiology, College of Veterinary Medicine, Michigan State University, East Lansing 48824.
authors.forename: R E
authors.initials: RE
authors.lastname: Perry
authors.forename: R E
authors.initials: RE
authors.lastname: Weller
authors.forename: R L
authors.initials: RL
authors.lastname: Buschbom
authors.forename: G E
authors.initials: GE
authors.lastname: Dagle
authors.forename: J F
authors.initials: JF
authors.lastname: Park
mesh_terms: D000280:Administration, Inhalation; D000704:Analysis of Variance; D000818:Animals; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000000981:diagnostic imaging* / Q000473:pathology*; D004285:Dogs; D005260:Female; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary; D011005:Plutonium; D011859:Radiography; D012044:Regression Analysis
chemical_list: D011005:Plutonium