Botulinum toxin in the treatment of chronic urinary retention in women.
Six women were identified as having difficulty in voiding or complete urinary retention due to abnormal myotonic-like electromyographic (EMG) activity in the striated muscle of the urethral sphincter. An attempt was made to improve voiding by injection of botulinum toxin into the striated sphincter muscle. Although 3 patients then developed transient stress incontinence, demonstrating that sufficient botulinum toxin had been given to cause sphincter weakness, no patient had significant symptomatic benefit.
Fowler
C J
CJ
Department of Uro-Neurology, National Hospital for Neurology and Neurosurgery, London.
Betts
C D
CD
Christmas
T J
TJ
Swash
M
M
Fowler
C G
CG
D000328:Adult; D001905:Botulinum Toxins / Q000627:therapeutic use*; D004576:Electromyography; D005260:Female; D006801:Humans; D008875:Middle Aged; D009132:Muscles / Q000503:physiopathology; D012648:Self Care; D014521:Urethra / Q000503:physiopathology; D014546:Urinary Catheterization; D016055:Urinary Retention / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology
D001905:Botulinum Toxins