title: Labyrinthotomy with streptomycin infusion: early results of a multicenter study. The LSI Multicenter Study Group.
abstract: Early results for hearing and vertigo are reported for 47 labyrinthotomies with streptomycin infusion (LSI) by 13 coinvestigator-surgeons. Sixty-eight percent of patients had worse hearing after surgery (10 dB or 15% word recognition). Patients with a preoperative pure-tone average better than or equal to 40 dB appeared to suffer less postoperative hearing loss than those with a greater preoperative deficit. Severe to profound postoperative hearing loss was experienced by 27 patients (57%), all of whom had preoperative pure-tone averages worse than 40 dB. Opening the endolymphatic space was associated with a deleterious effect on hearing. Because of persistent vertigo, 17 percent of patients required a secondary procedure during the period of observation. These early results indicate that LSI is associated with a significant risk of postoperative hearing loss. Of the 13 coinvestigator-surgeons, four have stopped using LSI, while one considers his results satisfactory. The remaining surgeons have taken an intermediate position and feel it is useful in selected cases. Longer follow-up is required to judge the efficacy of LSI for controlling vertigo. We are currently studying these long-term results.
authors.affiliation: Department of Otolaryngology, Henry Ford Hospital, Detroit, MI 48202.
authors.forename: E M
authors.initials: EM
authors.lastname: Monsell
authors.forename: C
authors.initials: C
authors.lastname: Shelton
mesh_terms: D000328:Adult; D000368:Aged; D001301:Audiometry, Pure-Tone; D003131:Combined Modality Therapy; D016503:Drug Delivery Systems; D007758:Ear, Inner / Q000187:drug effects* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006311:Hearing Disorders / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000601:surgery / Q000628:therapy*; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control; D013307:Streptomycin / Q000008:administration & dosage* / Q000494:pharmacology; D014717:Vertigo / Q000517:prevention & control
chemical_list: D013307:Streptomycin