[Thrombosis-inducing activity (TIA) in plasma of a patient with lung cancer, which disappeared after radiotherapy].
A 58-year-old man had been suffering from persistent right shoulder pain was admitted following detection of a Pancoast tumor in the right lung. On admission, there was elevation of peripheral platelet count, plasma FDP and fibrinogen levels and thrombosis-inducing activity (TIA) was detected in his plasma. After receiving 30 Gy of Liniack, the mass shadow and the shoulder pain disappeared, which was accompanied by the normalization of laboratory data and the disappearance of TIA from plasma. However, plasma TIA became positive again one month later, in association with reappearance of shoulder pain and elevation of FDP and fibrinogen levels, which were considered due to recurrence of the tumor, 30 Gy of Liniack together with thermotherapy was again given. There was no subsequent recurrence of tumor, nor TIA has been detected for more than 3 years.
Hayashi
S
S
Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Ogino
H
H
Nomoto
Y
Y
Kawasaki
M
M
Miyagawa
Y
Y
Hirano
H
H
Tanaka
K
K
Nakanishi
M
M
Ichinose
Y
Y
Yagawa
K
K
D001779:Blood Coagulation Factors / Q000032:analysis*; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D010178:Pancoast Syndrome / Q000097:blood* / Q000532:radiotherapy
D001779:Blood Coagulation Factors; D005338:Fibrin Fibrinogen Degradation Products; D005340:Fibrinogen