title: Repair of chronic tympanic membrane perforations using epidermal growth factor.
abstract: Perforation of the tympanic membrane (TM) is a frequent cause of conductive hearing loss. Persistent TM perforations often require surgical repair with an autologous tissue graft to restore hearing and prevent recurrent infection. While highly efficacious, this method of closure requires a relatively complex and expensive microsurgical procedure. We have recently developed a chronic TM perforation model in the chinchilla for use in the exploration of novel methods of TM repair.
authors.affiliation: Coleman & Epstein Neurotological Laboratories, Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco.
authors.forename: C P
authors.initials: CP
authors.lastname: Amoils
authors.forename: R K
authors.initials: RK
authors.lastname: Jackler
authors.forename: L R
authors.initials: LR
authors.lastname: Lustig
mesh_terms: D000818:Animals; D002682:Chinchilla; D004815:Epidermal Growth Factor / Q000627:therapeutic use*; D009225:Myringoplasty; D011994:Recombinant Proteins / Q000627:therapeutic use; D014432:Tympanic Membrane / Q000033:anatomy & histology / Q000293:injuries / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D011994:Recombinant Proteins; D004815:Epidermal Growth Factor