Direct membrane damage and miconazole lethality.
Physicochemical membrane damage is presumably the cause of growth phase-dependent lethal miconazole action. In support of this, we showed that as stationary phase inoculum cells of Candida albicans progress into early logarithmic phase, susceptibilities to lethal action and to miconazole-induced release of K+ increase together.
Beggs
W H
WH
VA Medical Center, Minneapolis, MN 55417.
D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D002453:Cell Cycle / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects; D006131:Growth Inhibitors / Q000633:toxicity*; D008825:Miconazole / Q000633:toxicity*; D011188:Potassium / Q000378:metabolism
D006131:Growth Inhibitors; D008825:Miconazole; D011188:Potassium