[The expression of IL-2 receptor subunits on various leukemic cells].
Interleukin-2 receptors are composed of at least two polypeptide chains of alpha (55KD) and beta (75KD). The IL-2R beta chain is an essential component of the functional receptor for signal transduction of IL-2. We previously reported the distribution of IL-2R subunits among peripheral blood mononuclear cells. We here present some data regarding the expression of IL-2R subunits on various hemopoietic malignant cells. Fresh leukemic cells obtained from adult T cell leukemia patients expressed both alpha and beta chains, and leukemic cells derived from some patients with T cell leukemia, B cell leukemia or myeloid leukemia expressed the alpha and/or beta chain of IL-2R. The IL-2R beta chain on these leukemic cells were demonstrated to be functional for cell growth signaling. IL-2R alpha and beta chains should be tumor markers.
Ohashi
Y
Y
Department of Microbiology, Tohoku University School of Medicine.
Kurahayashi
Y
Y
Ikeda
S
S
Arima
N
N
Sasaki
T
T
Tamate
E
E
Yokomichi
H
H
Sugamura
K
K
D014408:Biomarkers, Tumor / Q000032:analysis*; D002454:Cell Differentiation; D002455:Cell Division; D005434:Flow Cytometry; D006801:Humans; D007938:Leukemia / Q000175:diagnosis* / Q000473:pathology; D010446:Peptide Fragments / Q000032:analysis; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D015398:Signal Transduction
D014408:Biomarkers, Tumor; D010446:Peptide Fragments; D015375:Receptors, Interleukin-2