title: Cemented versus noncemented total hip arthroplasty--embolism, hemodynamics, and intrapulmonary shunting.
abstract: Bone cement implantation syndrome is characterized by hypotension, hypoxemia, cardiac arrhythmias, cardiac arrest, or any combination of these complications. It may result from venous embolization that occurs in conjunction with intramedullary hypertension in the femur during insertion of the prosthesis in patients undergoing cemented total hip arthroplasty (THA). Intramedullary hypertension does not occur in patients undergoing noncemented THA. In this study, we sought to compare embolization between patients undergoing cemented and noncemented THA and to determine whether this state resulted in cardiorespiratory deterioration. In this prospective investigation of 35 patients undergoing elective THA, we used transesophageal echocardiography and invasive hemodynamic monitoring, and in 12 of them, we monitored distribution of pulmonary ventilation and perfusion intraoperatively. Embolization was significantly greater after insertion of the prosthesis in patients undergoing cemented than in those undergoing noncemented THA. Cemented THA was also associated with decreased cardiac output and increased pulmonary artery pressure and pulmonary vascular resistance. Increases in ventilation-perfusion mismatching, however, could not be demonstrated 30 minutes after insertion of the femoral prosthesis. Intraoperative monitoring for embolism may help physicians assess patients in whom cardiorespiratory function deteriorates during THA.
authors.affiliation: Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905.
authors.forename: M H
authors.initials: MH
authors.lastname: Ereth
authors.forename: J G
authors.initials: JG
authors.lastname: Weber
authors.forename: M D
authors.initials: MD
authors.lastname: Abel
authors.forename: R L
authors.initials: RL
authors.lastname: Lennon
authors.forename: D G
authors.initials: DG
authors.lastname: Lewallen
authors.forename: D M
authors.initials: DM
authors.lastname: Ilstrup
authors.forename: K
authors.initials: K
authors.lastname: Rehder
mesh_terms: D000368:Aged; D001843:Bone Cements; D002484:Cementation; D004452:Echocardiography; D004617:Embolism / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006331:Heart Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology*; D006439:Hemodynamics; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011474:Prosthesis Design; D014692:Ventilation-Perfusion Ratio
chemical_list: D001843:Bone Cements