Enhancement by cyclosporin A of metastasis from hamster cheek pouch carcinoma.
Daily intravenous administration of 50 mg/kg cyclosporin A (CsA), after excision of cheek pouch tumors induced with 9,10-dimethyl-1,2-benzanthracene (DMBA), enhanced the incidence of cervical lymph node metastasis to 93%, a significant increase over the rates observed for animals receiving a dosage of 25 mg/kg (43%), and for control animals receiving no CsA (40%). No significant effect was evident on the growth rates of the metastasized tumour cells in the lymph node.
Yamada
T
T
Department of Oral and Maxillofacial Surgery I, Matsumoto Dental College, Nagano, Japan.
Mogi
M
M
Kage
T
T
Ueda
A
A
Nakajima
J
J
Chino
T
T
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D003043:Cocarcinogenesis; D006224:Cricetinae; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects*; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary; D008207:Lymphatic Metastasis / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008647:Mesocricetus; D009062:Mouth Neoplasms / Q000473:pathology* / Q000601:surgery; D009333:Neck; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D013997:Time Factors
D015127:9,10-Dimethyl-1,2-benzanthracene; D016572:Cyclosporine