Flexibilized gelatin film-based artificial skin model: II. Release kinetics of incorporated bioactive molecules.
Any delivery system for bioactive molecules should have the ability to release the compound in question in a reproducible and predictable way over a certain period. For artificial skin models that are designed to enhance healing by the use of growth factors, this requirement poses another problem: the design of a delivery method that can provide a realistic assessment of the release kinetics. This means that the design should "mimic" conditions encountered in an open wound, i.e., only a certain part of the film can face the wound, from which it can absorb wound fluid that will dissolve the incorporated bioactive molecule and bring it to the open wound. Such a system has been developed and the release of 125I-labelled insulin, incorporated into flexibilized gelatin films, has been determined. The details of this study follow.
Shinde
B G
BG
Center for Protein and Polymer Research, Albert Einstein Medical Center, Philadelphia, Pennsylvania 19141.
Erhan
S
S
D017364:Collagenases / Q000494:pharmacology; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004353:Drug Evaluation, Preclinical; D005780:Gelatin / Q000627:therapeutic use*; D006133:Growth Substances / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D007328:Insulin / Q000493:pharmacokinetics; D007457:Iodine Radioisotopes; D008422:Materials Testing; D008567:Membranes, Artificial; D015203:Reproducibility of Results
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006133:Growth Substances; D007328:Insulin; D007457:Iodine Radioisotopes; D008567:Membranes, Artificial; C015233:gelatin film; D005780:Gelatin; D017364:Collagenases