title: [The prolonged use of calcium antagonists in myocardial infarct in rats: their effect on hemodynamics and the contractile function and morphology of the heart muscle].
abstract: Experiments on rats with myocardial infarction induced by occlusion of the left coronary artery were made to explore the influence of calcium antagonists injected intraperitoneally for a long time (daily, for 21 days) on hemodynamics, contractile function and morphology of the heart muscle. It has been shown that verapamil (0.5 mg/kg), diltiazem (2 mg/kg) and nimodipine (20 micrograms/kg) do not exert under those conditions any noticeable effect on pump and contractile heart functions. Administration of verapamil in a doze of 2 mg/kg enhanced heart failure. The drugs under study normalized the response of contractile heart function to volumetric load, which is related to a considerable measure to the acceleration of reparative processes in the myocardium.
authors.forename: G V
authors.initials: GV
authors.lastname: Kazanova
authors.forename: I B
authors.initials: IB
authors.lastname: Tsorin
authors.forename: G G
authors.initials: GG
authors.lastname: Chichkanov
authors.forename: S P
authors.initials: SP
authors.lastname: Zakharov
authors.forename: A I
authors.initials: AI
authors.lastname: Shchegolev
authors.forename: A N
authors.initials: AN
authors.lastname: Iavorskiĭ
authors.forename: B I
authors.initials: BI
authors.lastname: Liubimov
mesh_terms: D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology / Q000627:therapeutic use*; D004110:Diltiazem / Q000494:pharmacology / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology*; D009553:Nimodipine / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D013997:Time Factors; D014700:Verapamil / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D002121:Calcium Channel Blockers; D009553:Nimodipine; D014700:Verapamil; D004110:Diltiazem
vernacular_title: Dlitel'noe primenenie antagonistov kal'tsiia pri infarkte miokarda u krys: vliianie na gemodinamiku, sokratitel'nuiu funktsiiu i morfologiiu serdechnoĭ myshtsy.