Cerebrovascular injuries induced by activation of platelets and leukocytes in vivo and their correction by neurotropin.
Ischemia-like brain damage was induced in cats by selective injection of 4 beta-phorbol-12 beta-myristate-13 alpha-acetate (PMA) into the left carotid artery. PMA-injection provoked significant decreases in platelet and neutrophil counts due to their intravascular aggregation. Platelet and neutrophil aggregates caused brain edema with accumulation of sodium fluorescein in the cerebrospinal fluid and ipsilateral derangement of the cerebral energy state in the parietal cortex. Neurotropin administration decreased the changes in platelet and neutrophil counts and prevented the developments of both brain edema and cerebral energy failure.
Gabrielian
E S
ES
Department of Pharmacology, Yerevan Medical Institute, Armenia.
Akopov
S E
SE
Grigorian
M R
MR
Toumasian
K S
KS
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects; D001929:Brain Edema / Q000188:drug therapy; D002339:Carotid Arteries; D002415:Cats; D002449:Cell Aggregation / Q000187:drug effects; D002561:Cerebrovascular Disorders / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D007269:Injections, Intra-Arterial; D007958:Leukocyte Count / Q000187:drug effects; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D010296:Parietal Lobe / Q000187:drug effects* / Q000378:metabolism; D010974:Platelet Aggregation / Q000187:drug effects*; D010976:Platelet Count; D011134:Polysaccharides / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000008:administration & dosage / Q000494:pharmacology*
D011134:Polysaccharides; C010491:neurotropin; D013755:Tetradecanoylphorbol Acetate