[An increase in the immunogenicity of bacterial antigens under the influence of one of the derivatives of muramyl dipeptide].
As revealed in animal experiments, glucosaminylmuramyl dipeptide (GMDP), the synthetic analog of muramyl dipeptide, when introduced intraperitoneally in a single injection or orally, exhibits adjuvant activity with respect to Citrobacter 0-antigens, Shigella flexneri and enhances the protective properties of dysentery and pertussis vaccines. The stimulating properties of GMDP depend on its dose, the route of its administration, the time elapsed after its administration, its ratio to the concomitant doses of bacterial antigens and to the dose of the virulent culture used for challenge.
Britsina
M V
MV
Shepeleva
I B
IB
Baturo
A P
AP
Elkina
S I
SI
Kalina
N G
NG
Andronova
T M
TM
Ermolova
E V
EV
Zakharova
N S
NS
Ivanov
V T
VT
Sokolova
T V
TV
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000008:administration & dosage / Q000187:drug effects* / Q000276:immunology; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology; D001886:Bordetella pertussis / Q000276:immunology; D002954:Citrobacter / Q000276:immunology; D007114:Immunization; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000276:immunology; D011817:Rabbits; D012763:Shigella flexneri / Q000276:immunology; D012995:Solubility
D000276:Adjuvants, Immunologic; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D010567:Pertussis Vaccine; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C023868:N-acetyl-beta-glucosaminyl-N-acetylmuramyl-alanylisoglutamine
Povyshenie immunogennosti bakterial'nykh antigenov pod vliianiem odnogo iz derivatov muramildipeptida.