Influence of amorolfine on the morphology of Candida albicans and Trichophyton mentagrophytes.
Amorolfine applied in concentrations of 0.1-100 micrograms/ml causes considerable damage to the ultrastructure of Candida albicans and Trichophyton mentagrophytes: electron-lucent areas appear in the cytoplasm; extracytoplasmic membrane vesicles are formed and deposited in the cell wall; starved fungal cells, with normal ultrastructure, can be found; lysed, dead cells demonstrate the process of severe ultrastructural damage; T. mentagrophytes cell walls especially increase in thickness. The extent of the damage caused by amorolfine is comparable to that produced by azole antifungals.
Müller
J
J
Mycology Section, Institute for Medical Microbiology and Hygiene, University of Freiburg, Germany.
Polak-Wyss
A
A
Melchinger
W
W
D002176:Candida albicans / Q000187:drug effects / Q000648:ultrastructure*; D008854:Microscopy, Electron; D009025:Morpholines / Q000494:pharmacology*; D014249:Trichophyton / Q000187:drug effects / Q000648:ultrastructure*
D009025:Morpholines; C038974:amorolfine