Age-related variations of enzymatic defenses against free radicals and peroxides.
Superoxide dismutase, glutathione peroxidase and catalase are the three main enzymatic systems of defense of the organism against free radicals and peroxides. A survey of the literature shows that no general tendency of evolution of these systems in aging emerges, even if some recent studies in humans demonstrate the existence of a concomitant decrease in most of the antioxidant enzymes in blood of the elderly. The study of the antioxidant systems and their interrelations in the elderly represents a large field of future investigations.
Artur
Y
Y
Centre de Médecine Préventive, Vandoeuvre-lès-Nancy, France.
Herbeth
B
B
Guémouri
L
L
Lecomte
E
E
Jeandel
C
C
Siest
G
G
D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002374:Catalase / Q000378:metabolism*; D005609:Free Radicals; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008875:Middle Aged; D010545:Peroxides / Q000378:metabolism*; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism*
D000975:Antioxidants; D005609:Free Radicals; D010545:Peroxides; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase