Synthesis and serotonergic pharmacology of the enantiomers of 3-[(N-methylpyrrolidin-2-yl)methyl]-5-methoxy-1H-indole: discovery of stereogenic differentiation in the aminoethyl side chain of the neurotransmitter serotonin.
Macor
J E
JE
Department of Medicinal Chemistry, Pfizer, Inc, Groton, Connecticut 06340.
Blake
J
J
Fox
C B
CB
Johnson
C
C
Koe
B K
BK
Lebel
L A
LA
Morrone
J M
JM
Ryan
K
K
Schmidt
A W
AW
Schulz
D W
DW
D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000494:pharmacology; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D017366:Serotonin Receptor Agonists / Q000138:chemical synthesis* / Q000494:pharmacology; D013237:Stereoisomerism
D007211:Indoles; D011759:Pyrrolidines; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; D012701:Serotonin