title: MR imaging of experimental meningeal melanomatosis in nude rats.
abstract: MR imaging of the rat brain has become an increasingly frequently used method in experimental neuroradiology. On a generally available 1.5 T whole body tomograph, supplemented with an individually made small coil and a special SE sequence we obtained fairly fine images of the structures of the rat brain. With gadolinium-DTPA, we were able to visualize posterior fossa and cervical leptomeningeal growth of intrathecally injected B16 melanoma in nude rats. Using MRI to follow experimental leptomeningeal metastasis, may provide a new means for diagnostic evaluation and preclinical testing of treatment modalities.
authors.affiliation: Department of Neuroradiology, University of Tübingen, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Martos
authors.forename: D
authors.initials: D
authors.lastname: Petersen
authors.forename: U
authors.initials: U
authors.lastname: Klose
authors.forename: H
authors.initials: H
authors.lastname: Requardt
authors.forename: R
authors.initials: R
authors.lastname: Buchholz
authors.forename: P
authors.initials: P
authors.lastname: Ohneseit
authors.forename: M
authors.initials: M
authors.lastname: Schabet
authors.forename: K
authors.initials: K
authors.lastname: Voigt
mesh_terms: D000818:Animals; D002946:Cisterna Magna / Q000473:pathology; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D008279:Magnetic Resonance Imaging; D008545:Melanoma / Q000175:diagnosis* / Q000473:pathology; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D009368:Neoplasm Transplantation; D009942:Organometallic Compounds; D004369:Pentetic Acid; D051381:Rats; D011923:Rats, Nude; D013116:Spinal Cord / Q000473:pathology
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA