title: [Generalized histoplasmosis due to Histoplasma duboisii with mediastino-pulmonary infection. Cure after 15 months of treatment with ketoconazole].
abstract: We report a case of a young burkinabian, who presented with the disseminated african form of histoplasmosis, Histoplasma duboisii. There was pulmonary mediastinal disease with superficial lymphadenopathy and also hepatic involvement. The diagnosis was achieved by a histological examination of the peripheral glands and micrological examination of the expectorate. A clinical cure (despite the radiological persistence of enlarged but stable left hilar glands) with the follow up 10 months was achieved after 15 months of treatment with ketoconazole in a dose which was increased to 10 mg/kg/day.
authors.affiliation: Service d'Anesthésie-Réanimation, Hôpital de Bobo Dioulasso, Burkina Faso.
authors.forename: C
authors.initials: C
authors.lastname: Delclaux
authors.forename: R
authors.initials: R
authors.lastname: Schutz
authors.forename: M
authors.initials: M
authors.lastname: Calzolari
authors.forename: E
authors.initials: E
authors.lastname: Balloul
authors.forename: B
authors.initials: B
authors.lastname: Zango
mesh_terms: D001706:Biopsy; D002050:Burkina Faso; D002648:Child; D005260:Female; D006660:Histoplasmosis / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D007654:Ketoconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008172:Lung Diseases, Fungal / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D008477:Mediastinal Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D013183:Sputum / Q000382:microbiology
chemical_list: D007654:Ketoconazole
vernacular_title: Histoplasmose généralisée à Histoplasma duboisii avec atteinte médiastino-pulmonaire. Guérison après 15 mois de traitement par kétoconazole.