[Cytoplasmic casein kinase 2 and its substrate proteins in the brain in Alzheimer's disease].
The absence of casein kinase 2 on blots of temporal cortex extracts from Alzheimer's disease patients (ADP) was shown using antiserum to casein kinase 2. Casein kinase 2 activity towards endogenous substrates and casein is 2-5 times less in ADP brain in comparison to normal controls. The fractions of heparin-binding proteins, containing protein substrates for phosphorylation, were isolated from temporal cortex of ADP and normal controls. The total amount of heparin-binding proteins from ADP brains is less than from control brains, and the polypeptide composition of these fractions is much more poop.
Aksenova
M V
MV
Karaseva
M V
MV
Burbaeva
G Sh
GSh
D000368:Aged; D000544:Alzheimer Disease / Q000201:enzymology*; D001345:Autoradiography; D047388:Casein Kinases; D003593:Cytoplasm / Q000201:enzymology*; D004586:Electrophoresis; D006801:Humans; D015151:Immunoblotting; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000032:analysis; D010455:Peptides / Q000032:analysis; D011494:Protein Kinases / Q000032:analysis*; D013702:Temporal Lobe / Q000201:enzymology*
D009419:Nerve Tissue Proteins; D010455:Peptides; D011494:Protein Kinases; D047388:Casein Kinases
Tsitoplazmaticheskaia kazeinkinaza 2 i ee substratnye belki v mozge pri bolezni Al'tsgeĭmera.