Effect of coronary perfusion of heptanol or potassium on conduction and ventricular arrhythmias.
Abnormalities in cellular coupling, modulated in part by intracellular gap junctions, have an important role in the genesis of reentrant arrhythmias in the setting of chronic myocardial infarction. The effects of heptanol, which has a relatively selective action on gap junctional resistance at low concentrations, and potassium, which primarily affects active membrane properties, were assessed using a localized intracoronary infusion system in 11 normal dogs in vivo. Both agents caused a dose-related slowing of conduction. Programmed stimulation during potassium infusion resulted in ventricular fibrillation in two of six animals treated with a low dose (5.0-5.5 meq/l) and five of six animals treated with a high dose (7.0-7.5 meq/l). During the infusion of 1.0 mM heptanol, uniform ventricular tachycardia was induced in four of eight animals. Infusion of heptanol, but not potassium, increased the susceptibility to presumably reentrant ventricular tachycardia in normal myocardium. This suggests that agents that affect cellular coupling may have markedly different arrhythmogenic consequences than agents that primarily alter active membrane properties.
Callans
D J
DJ
Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104.
Kieval
R S
RS
Hook
B G
BG
Moore
E N
EN
Spear
J F
JF
D000438:Alcohols / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D002304:Cardiac Pacing, Artificial; D003326:Coronary Circulation; D004285:Dogs; D004594:Electrophysiology; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects*; D006339:Heart Rate; D019850:Heptanol; D008297:Male; D010496:Pericardium / Q000502:physiology; D011188:Potassium / Q000008:administration & dosage* / Q000494:pharmacology; D011930:Reaction Time; D012016:Reference Values; D017180:Tachycardia, Ventricular / Q000209:etiology*
D000438:Alcohols; D019850:Heptanol; D011188:Potassium