[Pathomorphology of acute and chronic stages of CCl4-induced liver fibrosis: immunohistochemical and in situ hybridization studies].
The cellular localization of expression of various genes activated during the course of liver fibrosis and regeneration was studied by immunohistology and in situ hybridization in rat and human liver tissues. Mesenchymal cells proved to be the principal sources of extracellular matrix proteins and of fibrogenic growth factors, whereas the collagenase-activating protease transin/stromelysin gene was transcribed in parenchymal cells as well. Fibrogenesis by the mesenchymal compartment appears to be balanced by fibrolysis controlled by parenchymal cell functions. Continuous parenchymal damage may thus disrupt this balance between fibrogenesis and fibrolysis, resulting in fibrosis.
Herbst
H
H
Institut für Pathologie, Klinikum Steglitz, Freie Universität Berlin, BRD.
Milani
S
S
Heinrichs
O
O
Schuppan
D
D
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D016326:Extracellular Matrix Proteins / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D007124:Immunoenzyme Techniques; D017403:In Situ Hybridization; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000235:genetics / Q000473:pathology*; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced* / Q000235:genetics / Q000473:pathology; D008115:Liver Regeneration / Q000235:genetics; D011347:Procollagen / Q000096:biosynthesis / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis / Q000235:genetics; D015347:RNA Probes; D051381:Rats; D014158:Transcription, Genetic / Q000235:genetics; D016212:Transforming Growth Factor beta / Q000502:physiology
D016326:Extracellular Matrix Proteins; D011347:Procollagen; D011518:Proto-Oncogene Proteins; D015347:RNA Probes; D016212:Transforming Growth Factor beta; D002251:Carbon Tetrachloride
Pathomorphologie akuter und chronischer Stadien der CCl4-induzierten Leberfibrose: Immunhistochemische und in situ Hybridisierungs-Untersuchungen.