title: Rat liver lysosome membranes are enriched in alpha-tocopherol.
abstract: The subcellular distribution of alpha-tocopherol has been studied in rat liver. Lysosomal membranes were found to be considerably enriched in alpha-tocopherol with 6300 pmol/mg membrane protein, whereas mitochondrial membranes and microsomes contained 530 and 200 pmol/mg membrane protein, respectively. The 37-fold higher specific content of alpha-tocopherol in lysosomal membranes relative to homogenate indicates that lysosomes could be a target of cellular pathology in vitamin E deficiency states.
authors.affiliation: Department of Biochemistry, University of Western Ontario, London, Canada.
authors.forename: C A
authors.initials: CA
authors.lastname: Rupar
authors.forename: S
authors.initials: S
authors.lastname: Albo
authors.forename: J D
authors.initials: JD
authors.lastname: Whitehall
mesh_terms: D000818:Animals; D015415:Biomarkers; D004286:Dolichols / Q000378:metabolism; D007425:Intracellular Membranes / Q000737:chemistry; D008099:Liver / Q000737:chemistry* / Q000648:ultrastructure; D008247:Lysosomes / Q000737:chemistry*; D008297:Male; D008930:Mitochondria, Liver / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar / Q000378:metabolism; D014810:Vitamin E / Q000032:analysis*
chemical_list: D015415:Biomarkers; D004286:Dolichols; D014810:Vitamin E