title: [Sudden death due to bilateral pulmonary thromboembolism in a patient with multiple myeloma: an autopsy case report].
abstract: We encountered a patient with multiple myeloma who died suddenly, in whom bilateral pulmonary artery thrombosis was found at autopsy. The patient was a 50-year-old woman who had received chemotherapy for multiple myeloma at a local clinic for 4 years, and was transferred to our hospital because of recurrence of multiple myeloma in August 1990. Despite chemotherapy performed after admission, serum globulin level increased and her low back pain worsened, and she was generally restricted to bed. On October 21, she developed sudden dyspnea, became markedly cyanotic, lost consciousness, and then suffered a cardiopulmonary arrest. Autopsy revealed bilateral pulmonary artery thrombosis as well as thrombosis in the pelvic veins. Hyperviscosity due to multiple myeloma and long-term recumbency were the probable causes of pelvic venous thrombosis and subsequent pulmonary artery thrombosis. We report a rare case of bilateral pulmonary artery thrombosis which developed during the course of multiple myeloma and led to sudden death.
authors.affiliation: First Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Arai
authors.forename: M
authors.initials: M
authors.lastname: Nakata
authors.forename: J
authors.initials: J
authors.lastname: Yamazaki
authors.forename: T
authors.initials: T
authors.lastname: Shirai
authors.forename: H
authors.initials: H
authors.lastname: Nonaka
mesh_terms: D003645:Death, Sudden / Q000209:etiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000473:pathology; D011655:Pulmonary Embolism / Q000150:complications* / Q000473:pathology