Urinary fibrin and fibrinogen degradation products and the origin of hematuria.
We examined urinary fibrin and fibrinogen degradation product (U-FDP) concentrations in pediatric patients with hematuria using the rapid and highly-sensitive latex particle agglutination test (LPAT), and assessed the value of this test for the localization of the site of hematuria. Patients with hematuria were divided into two groups: 60 with glomerular hematuria and 46 with non-glomerular hematuria. If U-FDP concentrations less than 0.25 microgram/ml are accepted as an indicator of glomerular bleeding, the sensitivity and specificity of localization of glomerular hematuria in the present study were 78% (47/60) and 89% (41/46), respectively. The high U-FDP concentrations observed in patients with non-glomerular hematuria may reflect direct bleeding into the urinary tract. Since all 13 patients with glomerular hematuria and U-FDP concentrations of 0.25 microgram/ml or more had coexistent erythrocyte cylindruria, the U-FDP test seems to be compensated with combined urinalysis for the relatively lower sensitivity. We conclude that a knowledge of U-FDP concentrations by LPAT can be of help in localizing the site of bleeding in hematuria.
Tsukahara
H
H
Department of Pediatrics, Fukui Medical School, Japan.
Hiraoka
M
M
Sudo
M
M
Okada
T
T
Morikawa
K
K
Kuroda
M
M
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005069:Evaluation Studies as Topic; D005260:Female; D005337:Fibrin / Q000652:urine*; D005338:Fibrin Fibrinogen Degradation Products / Q000652:urine*; D006417:Hematuria / Q000145:classification / Q000453:epidemiology / Q000652:urine*; D006801:Humans; D007223:Infant; D007564:Japan / Q000453:epidemiology; D007841:Latex Fixation Tests; D008297:Male; D012680:Sensitivity and Specificity
D005338:Fibrin Fibrinogen Degradation Products; D005337:Fibrin