[Prevention of postischemic lesions of the myocardium using liposomes].
The experiments on dogs showed that 60-min blood flow restriction in the left coronary artery branch resulted in pumping and contractile heart dysfunctions. The removal of the blood flow barrier caused reinforcement of the above dysfunctions. The administration of 50 mg/kg liposome prior to reperfusion improved pumping and contractile heart functions and allowed maintenance of stable hemodynamics during the reperfusion.
Stefanov
A V
AV
Khromov
A S
AS
Zhukova
A V
AV
Sagach
V F
VF
Ivat'
O D
OD
Lishko
V K
VK
D000818:Animals; D003326:Coronary Circulation; D004285:Dogs; D005260:Female; D006439:Hemodynamics; D008081:Liposomes / Q000008:administration & dosage*; D008297:Male; D009200:Myocardial Contraction; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology / Q000517:prevention & control*
D008081:Liposomes
Preduprezhdenie postishemicheskikh povrezhdeniĭ miokarda s pomoshch'iu liposom.