Case report of an insulin-dependent diabetes multiplex family with a pair of identical twins.
The following is a case of a family with a pair of identical twins and a family history of insulin-dependent diabetes mellitus (IDDM). A 2 year old identical twin was first admitted to our hospital and diagnosed as IDDM based on diabetic ketoacidosis. His father has been treated with insulin since the diagnosis of IDDM at the age of 17. All family members had the HLA-DR4 and DQA1*0301 alleles, which are strongly associated with IDDM. The DR-DQ haplotypes of the father and both twins were DR4-DQW8 (DQB1*0302), which increases susceptibility to IDDM. Islet cell antibodies were positive only in the index twin at the time of diagnosis. The co-twin was considered to have beta-cell dysfunction based on the result of an intravenous glucose tolerance test.
Tsuchida
S
S
Hikone City Hospital, Japan.
Kaji
M
M
Nakata
Y
Y
Noguchi
C
C
Miura
T
T
Sudo
M
M
D000328:Adult; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D004200:Diseases in Twins / Q000175:diagnosis*; D005260:Female; D005951:Glucose Tolerance Test; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D010375:Pedigree; D014430:Twins, Monozygotic