Hexachlorophene induced alterations in brain carbohydrate metabolism of Wistar rat.
Effect of repeated oral administration of hexachlorophene (HCP) on glycolytic and oxidative pathways was studied in the rat brain. The rats were divided into three batches of six in each batch. The first batch was treated with paralytic dose (60 mg.kg-1.day-1) of HCP for 7 days. The second batch of animals was treated with sublethal dose (18 mg.kg-1.day-1) for 7 days. The third batch of animals was served as the age matched controls which received vehicle (corn oil) only. The glycolytic and oxidative metabolism of carbohydrates was significantly inhibited in the brain of rat during HCP treatment and the inhibition was more pronounced in paralytic dose treatment as compared to sublethal dose treatment. The inhibition of NADP-isocitrate dehydrogenase coupled with glucose 6-phosphate dehydrogenase indicates reduced generation of NADPH2 and pentoses for the synthesis of fatty acids and nucleotides.
Rajendra
W
W
Department of Zoology, Sri Venkateswara University, Tirupati, India.
Rao
P V
PV
Suhasini
N
N
Sailaja
P
P
D000284:Administration, Oral; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D050260:Carbohydrate Metabolism; D004305:Dose-Response Relationship, Drug; D004734:Energy Metabolism / Q000187:drug effects*; D005634:Fructose-Bisphosphate Aldolase / Q000037:antagonists & inhibitors / Q000187:drug effects; D006019:Glycolysis / Q000187:drug effects; D006582:Hexachlorophene / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D010088:Oxidoreductases / Q000037:antagonists & inhibitors / Q000187:drug effects; D006005:Phosphorylases / Q000037:antagonists & inhibitors / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
D010088:Oxidoreductases; D006005:Phosphorylases; D005634:Fructose-Bisphosphate Aldolase; D006582:Hexachlorophene