Effects of enalapril on adriamycin-induced nephrosis.
Adriamycin induces proteinuria and glomerular changes in rats similar to those found in human focal segmental glomerulosclerosis (FSGS). Progression of this lesion may be slowed by use of angiotensin converting enzyme inhibition. To evaluate this we injected two groups of Sprague-Dawley rats with Adriamycin (2 intravenous doses of 2 mg/kg given at an interval of 3 weeks). One group of rats received enalapril (50 mg/l) in their drinking water. Control rats were injected with saline. After 28 weeks, the mean whole kidney glomerular filtration rate was significantly less and proteinuria and sclerotic index were significantly greater in rats receiving adriamycin compared with controls (P < 0.05). Administration of enalapril did not decrease proteinuria (545 +/- 398 mg/day vs 494 +/- 325 mg/day, P >0.05) or improve the glomerular filtration rate (0.31 +/- 0.18 ml/min per g kidney weight vs 0.41 +/- 0.21 ml/min per g, P = 0.27). However, treatment with enalapril significantly reduced the mean glomerular sclerotic index compared with untreated rats (1.62 +/- 0.88 vs 0.82 +/- 0.49, P = 0.05). Enalapril may be beneficial in preserving glomerular structure in this experimental model of FSGS.
Irwin
K C
KC
Department of Pediatrics, Cleveland Clinic Foundation, Ohio 44195.
Brouhard
B H
BH
Satoh
S
S
Stowe
N T
NT
D000284:Administration, Oral; D000818:Animals; D004195:Disease Models, Animal; D004317:Doxorubicin; D004656:Enalapril / Q000008:administration & dosage / Q000627:therapeutic use*; D005919:Glomerular Filtration Rate / Q000502:physiology; D005923:Glomerulosclerosis, Focal Segmental / Q000139:chemically induced* / Q000188:drug therapy* / Q000473:pathology; D006439:Hemodynamics / Q000502:physiology; D007275:Injections, Intravenous; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D008297:Male; D009401:Nephrosis / Q000139:chemically induced* / Q000188:drug therapy*; D009929:Organ Size; D051381:Rats; D017207:Rats, Sprague-Dawley
D004656:Enalapril; D004317:Doxorubicin