Borna disease virus, a negative-strand RNA virus, transcribes in the nucleus of infected cells.
Borna disease virus, an unclassified infectious agent, causes immune-mediated neurologic disease in a wide variety of animal hosts and may be involved in pathogenesis of selected neuropsychiatric diseases in man. Initial reports suggested that Borna disease virus is a single-stranded RNA virus. We describe here a method for isolation of viral particles that has allowed definitive identification of the genome as containing a negative-polarity RNA. Further, we show that the viral mRNAs are transcribed in the nucleus.
Briese
T
T
Institute of Virology, Free University of Berlin, Federal Republic of Germany.
de la Torre
J C
JC
Lewis
A
A
Ludwig
H
H
Lipkin
W I
WI
D001891:Borna disease virus / Q000235:genetics*; D002467:Cell Nucleus / Q000382:microbiology; D002478:Cells, Cultured; D006801:Humans; D066298:In Vitro Techniques; D014176:Protein Biosynthesis; D012328:RNA Viruses / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics*; D014158:Transcription, Genetic; D014777:Virus Diseases / Q000235:genetics*
D012333:RNA, Messenger; D012367:RNA, Viral