title: Interleukin 2 production and its relationship with T lymphocyte subsets in patients with obstructive jaundice.
abstract: Sepsis remains a major risk in the high mortality and morbidity after surgery for obstructive jaundice. The reasons for the increased susceptibility to infection are unknown. This study examined interleukin 2 (IL-2) production and the lymphocyte response to PHA mitogen in 31 patients with obstructive jaundice. Among them, 18 patients were simultaneously investigated by enumeration of T lymphocyte subsets in peripheral blood with APAAP technique. The results showed that the patients had significantly decreased IL-2 production and lymphocyte response to PHA mitogen. The percentage of Leu 3a (helper/inducer T cell) in the patients was significantly lower than that in normal controls. Leu 3a/Leu 2a (suppressor/cytotoxic T cell) ratio was significantly lower in these patients. The reduction of IL-2 production correlated significantly with the suppression of lymphocyte proliferation but not with the percentage of Leu 3a cells. From these results, it may be suggested that the reduction of IL-2 production in the patients with obstructive jaundice is an important reason for the suppression of T lymphocyte proliferative response, not merely a reflection of the decrease of helper T cells.
authors.affiliation: Department of Surgery, Xiehe Hospital, Tongji Medical University, Wuhan.
authors.forename: H
authors.initials: H
authors.lastname: Li
authors.forename: S T
authors.initials: ST
authors.lastname: Xiong
authors.forename: S X
authors.initials: SX
authors.lastname: Zhang
authors.forename: S B
authors.initials: SB
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Luo
authors.forename: P
authors.initials: P
authors.lastname: Zou
authors.forename: J P
authors.initials: JP
authors.lastname: Xiang
mesh_terms: D000328:Adult; D000368:Aged; D001649:Bile Duct Diseases / Q000601:surgery; D001650:Bile Duct Neoplasms / Q000150:complications; D016516:CD4-CD8 Ratio; D002769:Cholelithiasis / Q000601:surgery; D001651:Cholestasis, Extrahepatic / Q000209:etiology / Q000276:immunology* / Q000601:surgery; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications; D016176:T-Lymphocyte Subsets
chemical_list: D007376:Interleukin-2