[The action of low doses of nitrosomethylurea on a stationary cell population. An experiment and modelling].
The change of stationary cell population (murine spleen) following an exposure to low doses of methylnitrosourea (10(-11)-10(-5) g/kg of mouse weight) was investigated and modelled mathematically. The suggested model is based on the idea that the effect of cytotoxic agent in low doses has nondestructive "signal" character, changing dynamic balance between cells in proliferating and quiescent compartments.
Krutova
T V
TV
Chernikova
S B
SB
Konradov
A A
AA
Burlakova
E B
EB
D000818:Animals; D001345:Autoradiography; D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D008433:Mathematics; D008770:Methylnitrosourea / Q000008:administration & dosage*; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D008954:Models, Biological; D013154:Spleen / Q000166:cytology / Q000187:drug effects*
D008770:Methylnitrosourea
Deĭstvie malykh doz nitrozometilmocheviny na statsionarnuiu kletochnuiu populiatsiiu. Eksperiment i modelirovanie.