Neuroreceptor imaging with SPECT.
Single photon emission computed tomography (SPECT) imaging can provide useful measurements of brain receptors and endogenous neurotransmitters and may have significant experimental and clinical applications. This presentation reviews the use of SPECT for neuroreceptor imaging. Studies of receptors for benzodiazepines, dopamine D2 agents, and dopamine reuptake sites will be used to exemplify the capabilities of SPECT. Tracers labeled with the radioisotope 125I have high affinity, high brain uptake, and high ratios of specific to nonspecific binding. Imaging studies of human and nonhuman primate brain will be presented, and the potential clinical applicability of these agents will be discussed.
Innis
R B
RB
Department of Psychiatry, Yale University, School of Medicine, Conn.
D006801:Humans; D007457:Iodine Radioisotopes; D008279:Magnetic Resonance Imaging; D001523:Mental Disorders / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000503:physiopathology; D011954:Receptors, Dopamine / Q000502:physiology; D011984:Sensory Receptor Cells / Q000000981:diagnostic imaging*; D015899:Tomography, Emission-Computed, Single-Photon / Q000295:instrumentation / Q000379:methods
D007457:Iodine Radioisotopes; D011954:Receptors, Dopamine