title: Tissue polypeptide antigen in breast cancer cytosol: a new effective prognostic indicator.
abstract: Since 1982 we have been evaluating oestrogen and progesterone receptors (PgR), cathepsin D and the cytosolic levels of the tumour marker, tissue polypeptide antigen (TPA), in 257 patients radically resected for breast cancer (follow-up 24-81 months). TPA was measured by an immunoradiometric assay previously validated for cytosol. No significant associations were found between cytosolic TPA and age, tumour size, lymph-node status, receptor status and cathepsin D. TPA+ cases showed a significantly longer disease-free survival (DFS) and overall survival (OS) than TPA-patients (log-rank P < 0.0001). The prognostic value of cytosolic TPA was also demonstrated after stratification by nodal status, PgR and cathepsin D. The prognostic value of TPA was independent of the other prognostic indicators, being the most powerful among the evaluated indices (Cox multivariate analysis: chi 2 15.5 for DFS, 11.4 for OS). We conclude that cytosolic TPA is a powerful additional prognostic factor in primary breast cancer. Its prognostic role should therefore be extensively evaluated.
authors.affiliation: Centro Regionale Indicatori Biochimici di Tumore, Ospedale Civile, ULSS 16 Venezia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Gion
authors.forename: R
authors.initials: R
authors.lastname: Mione
authors.forename: G L
authors.initials: GL
authors.lastname: Pappagallo
authors.forename: C
authors.initials: C
authors.lastname: Gatti
authors.forename: O
authors.initials: O
authors.lastname: Nascimben
authors.forename: A
authors.initials: A
authors.lastname: Brandes
authors.forename: O
authors.initials: O
authors.lastname: Vinante
authors.forename: G
authors.initials: G
authors.lastname: Bruscagnin
mesh_terms: D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000276:immunology* / Q000401:mortality / Q000473:pathology; D003600:Cytosol / Q000737:chemistry; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D010455:Peptides / Q000032:analysis*; D011379:Prognosis; D019396:Tissue Polypeptide Antigen
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D010455:Peptides; D019396:Tissue Polypeptide Antigen