[Molecular aspects of IL-7-IL-7 receptor system].
IL-7 is a multifunctional cytokine which acts on cells such as B cells, T cells and macrophages. As the IL-7 clearly plays many important roles the in control of growth and differentiation, it is important to understand how IL-7 and IL-7 receptor (IL-7R) are expressed. Recently, to understand the transcriptional regulation of IL-7 and IL-7R genes, a detailed analysis of the 5' flanking region of the IL-7 and IL-7R genes has been done. In this review recent progress on these topics is introduced and discussed.
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D000818:Animals; D001483:Base Sequence; D004742:Enhancer Elements, Genetic; D005786:Gene Expression Regulation; D006801:Humans; D015851:Interleukin-7 / Q000235:genetics*; D008969:Molecular Sequence Data; D011971:Receptors, Immunologic / Q000235:genetics*; D020395:Receptors, Interleukin-7; D014158:Transcription, Genetic
D015851:Interleukin-7; D011971:Receptors, Immunologic; D020395:Receptors, Interleukin-7