Plasma cholinesterase isozymes and REM latency in schizophrenia.
The relation between electroencephalographic sleep parameters and plasma cholinesterase isozymes was examined in a group of 19 unmedicated schizophrenic patients. Rapid eye movement (REM) latency was found to be significantly inversely correlated with isozyme 3 (mainly acetylcholinesterase). The results are discussed in relation to cholinergic involvement in the regulation of REM sleep and in the pathophysiology of schizophrenia.
Keshavan
M S
MS
Dept. of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213.
Mahadik
S P
SP
Reynolds
C F
CF
Mukerjee
S
S
Korenovsky
A
A
Houck
P
P
Jarrett
D B
DB
D000328:Adult; D002802:Cholinesterases / Q000097:blood*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D008297:Male; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000201:enzymology* / Q000503:physiopathology; D012565:Schizophrenic Psychology; D012895:Sleep, REM / Q000502:physiology*; D013997:Time Factors
D007527:Isoenzymes; D002802:Cholinesterases