Two new alkaloids from Xestospongia sp., a New Caledonian sponge.
Five alkaloids have been isolated from a New Caledonian sponge Xestospongia sp. These include three known xestospongin derivatives, the new demethylxestospongin B (1) and a tetrahydrocarboline derivative 5. The structures of the new compounds 1 and 5 have been established by nmr studies and comparison with previously described products.
Quirion
J C
JC
Institut de Chimie des Substances Naturelles du CNRS, Gif-sur-Yvette, France.
Sevenet
T
T
Husson
H P
HP
Weniger
B
B
Debitus
C
C
D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D006801:Humans; D007624:KB Cells / Q000187:drug effects; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D047028:Macrocyclic Compounds; D009682:Magnetic Resonance Spectroscopy; D010080:Oxazoles; D011161:Porifera / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000470:Alkaloids; D000970:Antineoplastic Agents; D047028:Macrocyclic Compounds; D010080:Oxazoles; C078550:demethylxestospongine B; C078549:xestospongin B