Oxidative changes in brain of aniline-exposed rats.
Oxidative stress in rat cerebellum, cortex and brain stem after a short-term high-dose exposure to aniline vapors under conditions akin to those after major chemical accidents, was studied. Significant increases in superoxide dismutase isozyme activities and formation of thiobarbituric acid reactive material along with depletion of ascorbic acid and non-protein sulfhydryl content suggest impairment of antioxidant defenses 24 h after single exposure to 15,302 ppm aniline vapors for 10 min.
Kakkar
P
P
Ecotoxicology Section, Industrial Toxicology Research Centre, Lucknow, India.
Awasthi
S
S
Viswanathan
P N
PN
D000814:Aniline Compounds / Q000009:adverse effects*; D000818:Animals; D001933:Brain Stem / Q000187:drug effects* / Q000378:metabolism; D002531:Cerebellum / Q000187:drug effects* / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D004781:Environmental Exposure / Q000009:adverse effects*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000187:drug effects / Q000378:metabolism
D000814:Aniline Compounds; D013482:Superoxide Dismutase; C023650:aniline