[Kinetics of vaccination antibodies against tetanus toxoid, diphtheria toxoid, measles virus, poliomyelitis virus and pneumococcus after allogenic and autologous bone marrow transplantation and booster vaccination. 2: Kinetics of vaccination antibodies against diphtheria toxoid after allogenic and autologous bone marrow transplantation].
In the second part of the paper we report on the results of the diphtheria antitoxin valuation of 8 children after allogeneic bone marrow transplantation (BMT) with and without graft versus host disease (GvHD) as well as on the kinetics of the diphtheria antitoxin of 5 children after allogeneic BMT with and without GvHD and of 5 children after autologous transplantation. The antibody valuation was done by a cell-culture assay. Whereas the inspection of the isolated data gives the impression of a swift antibody decrease up to the non-protective level from the 7th month after BMT, the kinetic tests are more highly differentiated. Besides rapidly decreasing values below the accepted protection rate of 0.01 IU/ml in the allogeneic transplanted groups, there are patients with positive antibody titres within an observation period of up to 24 months after BMT in the allogeneic as well as in the autologous transplantation group.
Prager
J
J
Universitäts-Kinderklinik Jussuf Ibrahim Jena.
Thilo
W
W
Hermann
J
J
Fuchs
D
D
Zintl
F
F
D016026:Bone Marrow Transplantation / Q000276:immunology*; D002648:Child; D004166:Diphtheria Antitoxin / Q000032:analysis*; D004168:Diphtheria Toxoid / Q000276:immunology*; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000276:immunology*; D006801:Humans; D007117:Immunization, Secondary; D009894:Opportunistic Infections / Q000276:immunology
D004166:Diphtheria Antitoxin; D004168:Diphtheria Toxoid
Untersuchungen zur Kinetik der Impfantikörper gegen Tetanustoxoid, Diphtherietoxoid, Masern-Virus, Poliomyelitis-Virus und Pneumokokken nach allogener und autologer Knochenmarktransplantation und Wiederholungsimpfung. Teil 2: Kinetik der Impfantikörper gegen Diphtherietoxoid nach allogener und autologer Knochenmarktransplantation.