Assessment of anti-HIV activity of some benzimidazolylthiazoles.
Benzimidazolylthiazoles 2 were synthesized by condensing 1H-benzimidazole-2-acetonitrile (1) with sulphur and isothiocyanates. The syntheses of the Schiff bases 3, thioureas 4, and thiazolopyrimido[1,6-a]benzimidazoles 5 and 6 are also described. Seven compounds were evaluated in vitro against human HIV, however, no significant activity was observed with any of these compounds.
Badawey
E A
EA
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, A.R. Egypt.
Hazzaa
A A
AA
Rida
S M
SM
Fahmy
H T
HT
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D006678:HIV / Q000187:drug effects*; D006801:Humans
D000998:Antiviral Agents; D001562:Benzimidazoles