title: Pseudomembranous colitis in sickle cell disease responding to exchange transfusion.
abstract: We report a case of ischemic colitis with pseudomembrane formation in a 6 1/2-year-old boy with sickle cell disease that responded to medical management including exchange transfusion. This case was not associated with Clostridium difficile infection but with an elevation of serum levels of tumor necrosis factor alpha. This rare complication of sickle cell disease has been reported only in adults.
authors.affiliation: Division of Hematology, McGill University, Montreal, Quebec, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Baruchel
authors.forename: J C
authors.initials: JC
authors.lastname: Delifer
authors.forename: D
authors.initials: D
authors.lastname: Sigalet
authors.forename: A
authors.initials: A
authors.lastname: Hong
authors.forename: K
authors.initials: K
authors.lastname: Oudjhane
authors.forename: M F
authors.initials: MF
authors.lastname: Chen
mesh_terms: D015746:Abdominal Pain / Q000175:diagnosis / Q000209:etiology; D000208:Acute Disease; D000755:Anemia, Sickle Cell / Q000150:complications / Q000628:therapy*; D002648:Child; D016360:Clostridioides difficile; D003015:Clostridium Infections / Q000175:diagnosis; D003937:Diagnosis, Differential; D004761:Enterocolitis, Pseudomembranous / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D005078:Exchange Transfusion, Whole Blood; D006801:Humans; D008297:Male