[Effect of mexiletine on energy metabolism of ischemic brain in mice].
After 30 s ischemia induced by decapitation, the contents of ATP and phosphocreatine (PC) in mouse brain reduced, while that of lactic acid (LA) increased. When mexiletine (3.1-50 mg.kg-1) was injected ip 30 min before decapitation, the brain ATP and PC reduction, and LA accumulation were both alleviated in a dose-dependent manner. These findings suggested that mexiletine was effective in ameliorating the energy exhaustion in the ischemic brain.
Dong
L P
LP
Beijing Neurosurgical Institute, China.
Wang
T Y
TY
Zhang
L
L
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004734:Energy Metabolism / Q000187:drug effects*; D007773:Lactates / Q000378:metabolism; D008297:Male; D008801:Mexiletine / Q000494:pharmacology*; D051379:Mice; D010725:Phosphocreatine / Q000378:metabolism
D007773:Lactates; D010725:Phosphocreatine; D008801:Mexiletine; D000255:Adenosine Triphosphate