New hypoxanthine nucleosides with RNA antiviral activity.
A series of novel C-2 functionalized hypoxanthine and purine ribonucleosides have been synthesized and evaluated against exotic RNA viruses of the family or genus alpha, arena, flavi, and rhabdo. Both specific and broad-spectrum antiviral activities were discovered but only with hypoxanthine nucleosides.
Nair
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Department of Chemistry, University of Iowa, Iowa City 52242.
Ussery
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MA
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000494:pharmacology*; D007288:Inosine / Q000737:chemistry / Q000494:pharmacology*; D007739:L Cells; D051379:Mice; D011684:Purine Nucleosides / Q000494:pharmacology*; D012328:RNA Viruses / Q000187:drug effects*; D012263:Ribonucleosides / Q000494:pharmacology*; D014709:Vero Cells; D010948:Viral Plaque Assay
D000998:Antiviral Agents; D007042:Hypoxanthines; D011684:Purine Nucleosides; D012263:Ribonucleosides; D019271:Hypoxanthine; D007288:Inosine; C005248:nebularine