title: [New cytokines for negative growth regulation].
abstract: Considerable evidence has accumulated indicating that proliferation of animal cells is regulated by a balance between positive and negative growth stimuli. To clarify molecular species and physiological roles of growth inhibitors, we have been studying cytostatic or cytotoxic proteins present in different sources, such as sera and conditioned media of cultured cells. One cytostatic and two cytotoxic factors were recently purified from normal rabbit serum and characterized. Other groups also have reported various kinds of growth-inhibitory factors. The properties of these recently reported growth-inhibitory factors and their possible significance are summarized in this article.
authors.affiliation: Kihara Institute for Biological Research, Yokohama City University.
authors.forename: K
authors.initials: K
authors.lastname: Miyazaki
authors.forename: T
authors.initials: T
authors.lastname: Kimura
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002478:Cells, Cultured; D006131:Growth Inhibitors / Q000502:physiology*; D006801:Humans; D013274:Stomach Neoplasms / Q000378:metabolism; D014407:Tumor Cells, Cultured
chemical_list: D006131:Growth Inhibitors