title: Preparation and pharmacological evaluation of 4-(1,4-benzoquinon-2-yl)-4-phenylbutanamides as potential cerebral protective agents.
abstract: A new series of 4-(1,4-benzoquinon-2-yl)-4-phenylbutanamides (2) were synthesized for evaluation of their pharmacological activities. All these compounds synthesized showed significant antilipidperoxidation (ALP) activities with brain homogenate in rats and some of them possessed a protective effect against hypobaric hypoxia in mice. Especially, a thiomorpholine derivative (2l, SUN-4757) showed a wide efficacy spectrum to a variety of experimental screening assays designed for cerebral protective agents, and it had a high LD50 value.
authors.affiliation: Suntory Institute for Biomedical Research, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tatsuoka
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Imao
authors.forename: F
authors.initials: F
authors.lastname: Satoh
authors.forename: T
authors.initials: T
authors.lastname: Ishihara
authors.forename: I
authors.initials: I
authors.lastname: Hirotsu
authors.forename: T
authors.initials: T
authors.lastname: Kihara
authors.forename: M
authors.initials: M
authors.lastname: Hatta
authors.forename: Y
authors.initials: Y
authors.lastname: Horikawa
authors.forename: K
authors.initials: K
authors.lastname: Sumoto
mesh_terms: D000818:Animals; D016227:Benzoquinones / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D002317:Cardiovascular Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002534:Hypoxia, Brain / Q000517:prevention & control*; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D017208:Rats, Wistar
chemical_list: D016227:Benzoquinones; D002317:Cardiovascular Agents