Treatment parameters of desensitization to capsaicin.
Desensitization of sensory afferents with topical capsaicin has been employed to treat a variety of neuropathic disorders in humans, however, few studies have been undertaken to systematically evaluate treatment parameters to determine the optimal dose and frequency of treatment needed to achieve and maintain desensitization. The effects of several treatment parameters, including dose, number of exposures, interval between exposures and duration of exposure, on the development, magnitude and duration of desensitization following local treatment with capsaicin and related compounds are described.
Craft
R M
RM
Department of Pharmacology, University of Arizona Health Sciences Center, Tucson 85724.
Porreca
F
F
D000818:Animals; D002211:Capsaicin / Q000008:administration & dosage / Q000627:therapeutic use*; D015816:Cell Adhesion Molecules, Neuronal; D004334:Drug Administration Schedule; D006801:Humans; D009475:Neurons, Afferent / Q000502:physiology*; D017288:Pain Threshold / Q000187:drug effects*; D012683:Sensory Deprivation; D001743:Urinary Bladder / Q000187:drug effects / Q000294:innervation / Q000503:physiopathology
D015816:Cell Adhesion Molecules, Neuronal; D002211:Capsaicin