title: Influence of radiation treatment on serum transferrin and tumor necrosis factor-alpha.
abstract: This study deals with the effect of radiation treatment (RT) on serum transferrin and tumor necrosis factor-alpha (TNF-alpha) in patients with malignant tumors. In 21 patients who received 36-60 Gy in 20 to 30 sessions of RT, serum transferrin and TNF-alpha were determined pre-RT, after 10 to 15 sessions (middle of RT) and after 20 to 30 sessions (end of RT). The values of serum transferrin pre-RT were significantly higher than those in the middle and at the end of RT (p < 0.001). The values of TNF-alpha were increased by RT and were significantly higher at the end of RT as compared to the pre-RT values (p < 0.05). The values of serum transferrin and TNF-alpha show a tendency to negative correlation, either as a whole or separately pre- and under-RT. However, no correlation was statistically significant.
authors.affiliation: Aretaieon Hospital University of Athens, Department of Radiotherapy, Greece.
authors.forename: B
authors.initials: B
authors.lastname: Agroyannis
authors.forename: J
authors.initials: J
authors.lastname: Kouvaris
authors.forename: H
authors.initials: H
authors.lastname: Tzanatos
authors.forename: K
authors.initials: K
authors.lastname: Chondros
authors.forename: E
authors.initials: E
authors.lastname: Stringou
authors.forename: A
authors.initials: A
authors.lastname: Damatopoulou
authors.forename: A
authors.initials: A
authors.lastname: Dalamangas
authors.forename: D
authors.initials: D
authors.lastname: Koutsikos
authors.forename: C
authors.initials: C
authors.lastname: Papavasiliou
mesh_terms: D000368:Aged; D006801:Humans; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000532:radiotherapy*; D014168:Transferrin / Q000378:metabolism / Q000528:radiation effects*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism / Q000528:radiation effects*
chemical_list: D014168:Transferrin; D014409:Tumor Necrosis Factor-alpha