title: Antineutrophil cytoplasmic autoantibody-associated vasculitis presenting as Sjögren's syndrome.
abstract: A 63-year-old woman, in whom a diagnosis of Sjögren's syndrome was initially made, proved to have systemic vasculitis with salivary gland involvement and necrotizing and crescentic glomerulonephritis. Antineutrophil cytoplasmic autoantibodies (ANCA) against myeloperoxidase were positive. ANCA-associated vasculitis should be considered in the differential diagnosis of Sjögren's syndrome. A positive finding on immunoassay for ANCA against myeloperoxidase or proteinase 3 may help establish the diagnosis.
authors.affiliation: Leukocyte Biology and Inflammation Program, Massachusetts General Hospital, Harvard Medical School, Boston 02129.
authors.forename: E P
authors.initials: EP
authors.lastname: Böttinger
authors.forename: J L
authors.initials: JL
authors.lastname: Niles
authors.forename: A B
authors.initials: AB
authors.lastname: Collins
authors.forename: R T
authors.initials: RT
authors.lastname: McCluskey
authors.forename: M A
authors.initials: MA
authors.lastname: Arnaout
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000032:analysis*; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000175:diagnosis; D006801:Humans; D008875:Middle Aged; D012466:Salivary Gland Diseases / Q000175:diagnosis / Q000209:etiology; D012859:Sjogren's Syndrome / Q000175:diagnosis*; D013363:Submandibular Gland / Q000473:pathology; D014657:Vasculitis / Q000175:diagnosis* / Q000276:immunology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies