Treatment of hemophilia A by living mother-to-son splenic transplantation. First case report in the world.
A case of severe hemophilia A was treated by living mother-to-son splenic transplantation. The recipient was a 9-year-old boy. After splenic transplantation, the level of blood factor VIII:C was increased, and no spontaneous hemorrhage occurred. The boy was followed up for over two years. This is a case of spleen allotransplantation with the longest function in the world.
Xia
S S
SS
Institute of Organ Transplantation, Tongji Medical University, Wuhan.
Jiang
H C
HC
Zhou
X X
XX
He
G
G
D002648:Child; D005169:Factor VIII / Q000378:metabolism; D006467:Hemophilia A / Q000097:blood / Q000601:surgery*; D006801:Humans; D008297:Male; D013154:Spleen / Q000637:transplantation*
D005169:Factor VIII