title: Modulation of transient type K channel cloned from rat heart.
abstract: We have cloned a transient type K channel from rat heart (RH10) and coexpressed a metabotropic glutamate receptor (mGluR5) to study the functional modulation of RH10 coupled to the phosphatidylinositol (PI) hydrolysis. Stimulation of mGluR5 suppressed peak amplitude of RH10 current and affected voltage dependence of activation and inactivation of the channel.
authors.affiliation: Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Okada
authors.forename: K
authors.initials: K
authors.lastname: Ishii
authors.forename: K
authors.initials: K
authors.lastname: Nunoki
authors.forename: T
authors.initials: T
authors.lastname: Abe
authors.forename: N
authors.initials: N
authors.lastname: Taira
mesh_terms: D000818:Animals; D002118:Calcium / Q000494:pharmacology; D003001:Cloning, Molecular; D015723:Gene Library; D005971:Glutamates / Q000494:pharmacology*; D006321:Heart / Q000502:physiology*; D007700:Kinetics; D008564:Membrane Potentials / Q000187:drug effects; D009838:Oligodeoxyribonucleotides; D009865:Oocytes / Q000502:physiology*; D016133:Polymerase Chain Reaction; D015221:Potassium Channels / Q000235:genetics / Q000502:physiology*; D051381:Rats; D017470:Receptors, Glutamate / Q000235:genetics / Q000502:physiology*; D011994:Recombinant Proteins / Q000378:metabolism; D015183:Restriction Mapping; D014982:Xenopus laevis
chemical_list: D005971:Glutamates; D009838:Oligodeoxyribonucleotides; D015221:Potassium Channels; D017470:Receptors, Glutamate; D011994:Recombinant Proteins; D002118:Calcium