title: The prognostic significance of vascular invasion in upper urinary tract transitional cell carcinoma.
abstract: The prognostic significance of vascular invasion was evaluated in a retrospective series of 30 patients with upper urinary tract cancer who underwent a potentially curative operation. Vascular invasion was found in 11 patients (36.7%). The incidence of vascular invasion was well correlated with tumor grade and stage. The incidence of metastases postoperatively was significantly higher in the patients with (72.7%) than without (21.1%) vascular invasion (p < 0.01). The survival rate of the patients with vascular invasion was significantly lower than in those without vascular invasion (p < 0.005). In multivariate Cox regression analysis the prognostic value of vascular invasion was independent of tumor stage and grade. These results indicate that vascular invasion should predict a more unfavorable outcome in patients with upper urinary tract cancer as an independent morphological indicator.
authors.affiliation: Department of Urology, Miyazaki Medical College, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hasui
authors.forename: S
authors.initials: S
authors.lastname: Nishi
authors.forename: S
authors.initials: S
authors.lastname: Kitada
authors.forename: Y
authors.initials: Y
authors.lastname: Osada
authors.forename: Y
authors.initials: Y
authors.lastname: Asada
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000401:mortality / Q000473:pathology* / Q000556:secondary; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012044:Regression Analysis; D012189:Retrospective Studies; D015996:Survival Rate; D014652:Vascular Diseases / Q000473:pathology*