Divergent anti-HBc reactivities in HB-immune and chronic HBsAg carriers.
We have monitored titers of anti-HBc antibodies in sera from acutely HBV-infected and chronic HBsAg carriers. Our data show that there is a divergence in the specificity of the antibodies in these two populations. We also present preliminary results showing that serum from HB-immune carriers contain antibodies that are multispecific and display autoimmune characteristics, reacting with human serum albumin.
Hellström
U B
UB
Department of Infectious Diseases, Karolinska Institute, Roslagstull Hospital, Stockholm, Sweden.
Sylvan
S P
SP
D000918:Antibody Specificity; D002353:Carrier State / Q000276:immunology; D002908:Chronic Disease; D006509:Hepatitis B / Q000276:immunology*; D006510:Hepatitis B Antibodies / Q000096:biosynthesis*; D006512:Hepatitis B Core Antigens / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology
D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens