title: Nasopharyngeal bacterial flora in otitis prone children treated with immunoglobulin.
abstract: The present study was undertaken to evaluate possible beneficial effects of regularly given, long term immunoglobulin prophylaxis of children below 2 years of age with recurrent acute otitis media (RAOM). The nasopharyngeal bacterial flora and the frequency of acute otitis media (AOM) and secretory otitis media SOM were studied. Every second of 44 children with 3 or more periods of AOM during the last year received immunoglobulin intramuscularly (Gammaglobulin Kabi 165 mg/l, 0.45 ml/kg b.w.) every third week for 6 months, while the other 22 children served as controls. All children were followed for 12 months. Immunoglobulin prophylaxis neither influenced the nasopharyngeal flora, nor the frequency of AOM or SOM periods. Children with AOM or SOM more often harbored bacterial pathogens in their nasopharynx than children with normal middle ear status. Also, the immunoglobulin prophylaxis did not influence the increased frequency of bacterial pathogens in the nasopharynx of children attending public day care or family day care as compared to those taken care of at home.
authors.affiliation: Department of Clinical Immunology, University of Göteborg, Sweden.
authors.forename: F
authors.initials: F
authors.lastname: Jørgensen
authors.forename: B
authors.initials: B
authors.lastname: Andersson
authors.forename: S
authors.initials: S
authors.lastname: Larsson
authors.forename: O
authors.initials: O
authors.lastname: Nylén
mesh_terms: D000208:Acute Disease; D001419:Bacteria / Q000302:isolation & purification*; D002656:Child Day Care Centers; D005191:Family Characteristics; D006193:Haemophilus influenzae / Q000302:isolation & purification; D006801:Humans; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000008:administration & dosage; D007223:Infant; D007224:Infant Care; D007273:Injections, Intramuscular; D001936:Moraxella catarrhalis / Q000302:isolation & purification; D009305:Nasopharynx / Q000382:microbiology*; D010033:Otitis Media / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control*; D010034:Otitis Media with Effusion / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control; D010404:Penicillin V / Q000627:therapeutic use; D013211:Staphylococcus aureus / Q000302:isolation & purification; D013296:Streptococcus pneumoniae / Q000302:isolation & purification; D013297:Streptococcus pyogenes / Q000302:isolation & purification
chemical_list: D007136:Immunoglobulins; D010404:Penicillin V