Human growth hormone in polymethyl methacrylate. A controlled study of 15 hip arthroplasties.
Growth hormone-loaded polymethyl methacrylate (PMMA) was used in 15 hip replacements. The levels of growth hormone and insulin growth factor-I from the hip and the blood were measured before, and after, implanting PMMA containing 20 mg of growth hormone. Low levels of growth hormone and insulin growth factor-I were found in the femur initially, but very high local levels were found after implanting the growth hormone-loaded PMMA. These results were compared with the low levels found in 15 patients in a control group undergoing cemented or cementless hip replacement without added growth hormone. The local levels of growth hormone and insulin growth factor-I declined rapidly during the first 72 hours and were near normal at the end of this time. Systemic levels of growth hormone and insulin growth factor-I were not affected by the implantation of growth hormone-loaded PMMA. No complications or adverse reactions were noted. However, randomized studies with long-term follow-up are mandatory before the use of growth hormone-loaded PMMA is justified.
Pritchett
J W
JW
Department of Orthopedics, University of Washington, Seattle.
D000368:Aged; D004343:Drug Implants; D005260:Female; D013006:Growth Hormone / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D006622:Hip Prosthesis / Q000379:methods / Q000592:standards*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use*; D008297:Male; D020366:Methylmethacrylate; D008768:Methylmethacrylates / Q000008:administration & dosage / Q000627:therapeutic use*; D015207:Osteoarthritis, Hip / Q000097:blood / Q000601:surgery*
D004343:Drug Implants; D008768:Methylmethacrylates; D020366:Methylmethacrylate; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone