Endocytosis of calcium oxalate crystals and proliferation of renal tubular epithelial cells in a patient with type 1 primary hyperoxaluria.
A patient with primary hyperoxaluria who received a liver-kidney transplant is presented. A postoperative renal biopsy showed apparent tubular cell endocytosis of calcium oxalate crystals and cell proliferation, indicating that renal epithelial cells do not perceive urinary crystals as inert. Such cellular responses to crystals may have a role in nephrolithiasis.
Lieske
J C
JC
Department of Medicine, University of Chicago, Illinois 60637.
Spargo
B H
BH
Toback
F G
FG
D000328:Adult; D002129:Calcium Oxalate / Q000378:metabolism*; D002455:Cell Division; D004705:Endocytosis; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D006959:Hyperoxaluria / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D007676:Kidney Failure, Chronic / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D016030:Kidney Transplantation; D007684:Kidney Tubules / Q000473:pathology* / Q000503:physiopathology; D016031:Liver Transplantation
D002129:Calcium Oxalate