Evidence for antibody and immune-complex deposition in heart transplantation: a report of three cases.
Immunofluorescence microscopy of endomyocardial biopsy specimens from heart allograft recipients identified immunopathologic changes in three of 17 patients. These changes included immunoglobulin G and complement C3 deposition in tissue structures such as capillary endothelium and basal membranes, cardiomyocyte sarcolemma, and interstitial tissue. Moreover, the immunopathologic changes could be correlated with acute cellular rejection episodes evidenced by endomyocardial biopsy criteria.
Shumakov
V I
VI
Institute of Transplantation and Artificial Organs, Ministry of Public Health, Moscow, Russia.
Beletskaya
L V
LV
Baranova
F S
FS
Mogilevsky
G M
GM
Chestukhin
V V
VV
Kormer AYa
Kazakov
E N
EN
Khubutia
A S
AS
Kurenkova
L G
LG
Khalimova
Z A
ZA
D001706:Biopsy; D003176:Complement C3 / Q000032:analysis*; D004699:Endocardium / Q000276:immunology* / Q000473:pathology; D005455:Fluorescent Antibody Technique; D006084:Graft Rejection / Q000276:immunology* / Q000473:pathology; D016027:Heart Transplantation / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007165:Immunosuppression Therapy; D009206:Myocardium / Q000276:immunology* / Q000473:pathology
D003176:Complement C3; D007074:Immunoglobulin G