[Experience with using aclarubicin in the treatment of acute leukemia and blast crisis of chronic myeloid leukemia].
The clinical efficacy of aclarubicin, an anthracycline antibiotic, was studied in 48 patients with leukemia. The antibiotic was used in the following combinations with cytarabine: "7 + 7", "5 + 5" and "7 & 3". A complete remission was stated in 14 (42.4 per cent) out of 33 patients with acute nonlymphoid leukemia, 6 (43 per cent) out of the 14 patients having relapses. The combined therapy was effective in 4 out of 5 pre-resistant patients. The "7 + 3" scheme was the most beneficial. The most common adverse reactions were nausea and vomiting.
Savchenko
V G
VG
Isaev
V G
VG
Abakumov
E M
EM
Khoroshko
N D
ND
Turkina
A G
AG
Sokolov
A N
AN
Viadro
M M
MM
Navashin
S M
SM
D015250:Aclarubicin / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001752:Blast Crisis / Q000188:drug therapy*; D003561:Cytarabine / Q000008:administration & dosage*; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D007948:Leukemia, Monocytic, Acute / Q000188:drug therapy; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy* / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy; D015479:Leukemia, Myelomonocytic, Acute / Q000188:drug therapy; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy; D012074:Remission Induction
D003561:Cytarabine; D015250:Aclarubicin
Opyt primeneniia aklarubitsina v terapii ostrykh leĭkozov i blastnogo kriza khronicheskogo mieloleĭkoza.