[A comparative analysis of the action of oxidative metabolic inhibitors on the luminescence parameters of normal and tumorous cells].
Comparative investigation of different mitochondrial oxidative metabolism inhibitors action on NAD(P)H and flavoproteins fluorescence intensity of minimal transformed 3T3 NIH mouse fibroblasts and rat HTC hepatoma cells was made. Principle differences were shown between these cells in oxidized flavoproteins fluorescence intensity changes under the action of used inhibitors. It is suggested that the unusual HTC hepatoma cells flavin fluorescence intensity increase is connected with the oxidation of unidentified flavin-containing component functionally attached to mitochondrial respiratory chain.
Lebedev
O E
OE
Sergeenko
N G
NG
Sal'nikov
K V
KV
Barskiĭ
I Ia
IIa
D016475:3T3 Cells / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology*; D005420:Flavoproteins / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D005434:Flow Cytometry; D008114:Liver Neoplasms, Experimental / Q000378:metabolism*; D008163:Luminescent Measurements; D051379:Mice; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D009243:NAD / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D010084:Oxidation-Reduction / Q000187:drug effects / Q000528:radiation effects; D051381:Rats; D012016:Reference Values; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects
D000963:Antimetabolites; D005420:Flavoproteins; D009243:NAD
Sravnitel'nyĭ analiz deĭstviia ingibitorov okislitel'nogo metabolizma na liuminestsentnye parametry normal'nykh i opukholevykh kletok.