title: Solid and papillary neoplasm of the pancreas.
abstract: In two cases of solid and papillary neoplasm of the pancreas (SPN), positive staining for argyrophil granules, chromogranin-A, neuron-specific enolase, chymotrypsin, alpha 1-antitrypsin, vimentin, cytokeratin, and estrogen receptors was present. Ultrastructurally, neurosecretory as well as zymogenlike granules were demonstrated. Measurements of mean nuclear volume and volume-corrected mitotic index discriminated between SPN and well-differentiated ductal adenocarcinoma of the pancreas, with notably lower values being seen in SPN. Silver-stained nucleolar organizer region counts showed wide overlaps. The results suggest that SPN is a tumor with mixed endocrine and exocrine features. Its low malignant potential compared to ductal adenocarcinoma is reflected in the mean nuclear volume and volume-corrected mitotic index. The presence of estrogen receptors may prove therapeutically useful.
authors.affiliation: Department of Pathology and Surgical Gastroenterology, Hvidovre Hospital, Denmark.
authors.forename: L J
authors.initials: LJ
authors.lastname: Jørgensen
authors.forename: A B
authors.initials: AB
authors.lastname: Hansen
authors.forename: F
authors.initials: F
authors.lastname: Burcharth
authors.forename: E
authors.initials: E
authors.lastname: Philipsen
authors.forename: T
authors.initials: T
authors.lastname: Horn
mesh_terms: D000293:Adolescent; D000328:Adult; D002918:Chymotrypsin / Q000032:analysis; D004268:DNA-Binding Proteins / Q000032:analysis; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D010751:Phosphopyruvate Hydratase / Q000032:analysis
chemical_list: D004268:DNA-Binding Proteins; C068169:alpha 1-antitrypsin binding protein 1; D002918:Chymotrypsin; D010751:Phosphopyruvate Hydratase