Effects of estrogen on vein grafts.
The effect of estrogen on veins was evaluated in vitro and in vivo in three species. 17 beta-estradiol did not significantly alter 3H-thymidine uptake in vitro in segments from either canine femoral or human saphenous veins. In vivo in a rabbit carotid vein graft model, 17 beta-estradiol administration did not affect the development of intimal hyperplasia but was associated with a higher rate of graft thrombosis. These data suggest that the effects of estrogen on veins differs from the effects reported in arteries. These differences were seen both in vitro in veins taken from their normal location and in vivo in veins placed in the arterial circulation.
Calcagno
D
D
Georgetown University Medical Center, Washington, DC.
Bei
M
M
Ross
S A
SA
Klein
A
A
Foegh
M L
ML
D000328:Adult; D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology; D004958:Estradiol / Q000009:adverse effects / Q000494:pharmacology*; D005069:Evaluation Studies as Topic; D005260:Female; D005268:Femoral Vein / Q000187:drug effects* / Q000637:transplantation; D006083:Graft Occlusion, Vascular / Q000139:chemically induced / Q000453:epidemiology; D006801:Humans; D006965:Hyperplasia; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged; D011817:Rabbits; D012501:Saphenous Vein / Q000187:drug effects* / Q000637:transplantation; D013936:Thymidine / Q000493:pharmacokinetics
D004958:Estradiol; D013936:Thymidine