[The mechanism of the antioxidant action of D-penicillamine].
The mechanism of the antioxidative effect of D-penicillamine was studied under the conditions of NADPH- and CCl4-dependent lipid peroxidation in microsomes of rat liver and adrenalin autooxidation reaction. The antioxidative action of the drug was shown to be due to both its chelating properties and direct anti-radical influence. The chelating effect was more pronounced and depended on the concentration of ferric ions in the medium.
Soroka
N F
NF
Kostiuk
V A
VA
Potapovich
A I
AI
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002251:Carbon Tetrachloride / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000378:metabolism; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D009249:NADP / Q000494:pharmacology; D010084:Oxidation-Reduction / Q000187:drug effects; D010396:Penicillamine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D009249:NADP; D002251:Carbon Tetrachloride; D010396:Penicillamine; D004837:Epinephrine
Mekhanizm antioksidantnogo deĭstviia D-penitsillamina.