Respiratory dialysis. A new concept in pulmonary support.
Use of a new intravenous oxygenator made of hollow fiber membranes arranged around a centrally positioned balloon is reported. In vitro studies using fluorescent image tracking velocimetry and gas exchange analysis demonstrated enhanced convective mixing with balloon pulsations and augmented gas flux (100% increase in pO2) compared with the device in its static configuration. In vivo observations confirmed a greater than 50% increase in O2 flux with balloon activation. Those parameters that produce radial flow and convective mixing in vitro enhance gas flux in vivo, thus confirming the efforts to exceed the fluid limit translate into improved gas exchange.
Hattler
B G
BG
Department of Surgery, University of Pittsburgh, PA 15213.
Johnson
P C
PC
Sawzik
P J
PJ
Shaffer
F D
FD
Klain
M
M
Lund
L W
LW
Reeder
G D
GD
Walters
F R
FR
Goode
J S
JS
Borovetz
H S
HS
D000818:Animals; D001783:Blood Flow Velocity; D002245:Carbon Dioxide / Q000097:blood; D003956:Dialysis / Q000295:instrumentation; D004285:Dogs; D005069:Evaluation Studies as Topic; D066298:In Vitro Techniques; D010100:Oxygen / Q000097:blood; D010107:Oxygenators, Membrane; D012128:Respiratory Distress Syndrome / Q000097:blood / Q000503:physiopathology / Q000628:therapy*
D002245:Carbon Dioxide; D010100:Oxygen