Deletional types of alpha-thalassaemia in central Java.
The frequency of deletional alpha-thalassaemia in a Javanese population sample (n = 103) was investigated at three restriction sites of the alpha-globin gene (BamHI, BglII and RsaI). The overall gene frequency of alpha+ deletional thalassaemia was found to be very low (0.03). Leftward (-alpha 4.2) and rightward (-alpha 3.7) deletions and triplicated genes were present in equal frequency (0.015 and 0.005, respectively).
Tan
J A
JA
Department of Paediatrics, National University of Singapore.
Tay
J S
JS
Soemantri
A
A
Kham
S K
SK
Wong
H B
HB
Lai
P S
PS
Saha
N
N
D000328:Adult; D005260:Female; D017353:Gene Deletion; D005838:Genotype; D005914:Globins / Q000235:genetics; D006801:Humans; D015994:Incidence; D007214:Indonesia / Q000453:epidemiology; D008297:Male; D017085:alpha-Thalassemia / Q000453:epidemiology / Q000235:genetics*
D005914:Globins