title: Effects of the multiple risk factor intervention trial smoking cessation program on pulmonary function. A randomized controlled trial.
abstract: To determine whether the decline in pulmonary function in smokers is modified by stop-smoking intervention, a randomized controlled study (the Multiple Risk Factor Intervention Trial) was done comparing participants in a special intervention group that included an intensive smoking cessation program with those assigned to usual care. The subjects were 6,347 middle-aged male smokers who had serial measurements of pulmonary function--principally the forced expiratory volume in 1 second (FEV1)--during 6 to 7 years of follow-up. No overall differences were detected in the rate of loss of FEV1 in the two groups. The use of beta-blockers, which had detrimental effects on FEV1, was significantly more common in the intervention group. Among nonusers of beta-blockers, heavy smokers lost FEV1 at a rate about 11 ml per year slower in the intervention group than in the control group (2P = .09) and ended the trial with an FEV1 about 90 ml higher (2P = .05). These results support the inference from observational studies that smoking cessation has a beneficial effect on pulmonary function in heavy smokers.
authors.affiliation: Department of Epidemiology and Biostatistics, University of California, School of Medicine, San Francisco.
authors.forename: W S
authors.initials: WS
authors.lastname: Browner
authors.forename: A G
authors.initials: AG
authors.lastname: Du Chene
authors.forename: S B
authors.initials: SB
authors.lastname: Hulley
mesh_terms: D000328:Adult; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking / Q000503:physiopathology*; D016540:Smoking Cessation