Chronotherapy of malaria: improved efficacy of timed chloroquine treatment of patients with Plasmodium falciparum infections.
The effect of routine treatment with chloroquine (10 mg/kg on days 1 and 2 and 5 mg/kg on day 3) on parasitaemia and parasitaemic profile of patients infected with Plasmodium falciparum was studied. As with P. vinckei petteri, the mid-term trophozoites of P. falciparum were the most susceptible stages to chloroquine treatment. It is suggested that, in order to diminish the frequency of drug administration and to lower the risks of chemoresistance developing, treatment should be diversified, using the drug which is most effective on the parasite stages present in the peripheral blood.
Landau
I
I
Laboratoire de Zoologie, (Vers) associé au CNRS, Muséum National d'Histoire Naturelle, Paris, France.
Lepers
J P
JP
Ringwald
P
P
Rabarison
P
P
Ginsburg
H
H
Chabaud
A
A
D000818:Animals; D002738:Chloroquine / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development; D013997:Time Factors; D016896:Treatment Outcome
D002738:Chloroquine