title: Distribution of systemic blood flow in lambs with an aortopulmonary shunt during strenuous exercise.
abstract: We studied regional blood flows with radioactive-labeled microspheres in 12 7-wk-old lambs with an aortopulmonary left-to-right shunt [59 +/- 3% (SE) of left ventricular (LV) output] and in 11 control lambs, at rest and during exercise at 80% of predetermined peak O2 consumption. At rest, systemic blood flow was similar in the two groups. Blood flow to the heart and diaphragm was substantially higher in the shunt than in the control lambs. Blood flow to the other organs was not significantly different between the two groups. During exercise, systemic blood flow increased substantially but less in shunt (81%) than in control lambs (134%). Blood flow to the heart and diaphragm increased, that to the heart still being higher in shunt than in control lambs. Blood flow to the brain did not change, whereas that to the kidneys and splanchnic organs decreased to the same extent (25%) in shunt and control lambs. Intrahepatic and intrarenal blood flow redistribution in the shunt lambs persisted during exercise. In conclusion, myocardial blood flow is not increased at the expense of one particular organ, nor is it associated with an essential change in exercise-induced redistribution in shunt lambs.
authors.affiliation: Department of Pediatrics, University of Groningen, The Netherlands.
authors.forename: J W
authors.initials: JW
authors.lastname: Gratama
authors.forename: J J
authors.initials: JJ
authors.lastname: Meuzelaar
authors.forename: M
authors.initials: M
authors.lastname: Dalinghaus
authors.forename: J H
authors.initials: JH
authors.lastname: Koers
authors.forename: S
authors.initials: S
authors.lastname: Gratama
authors.forename: W G
authors.initials: WG
authors.lastname: Zijlstra
authors.forename: J R
authors.initials: JR
authors.lastname: Kuipers
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001784:Blood Gas Analysis; D002315:Cardiopulmonary Bypass; D006439:Hemodynamics / Q000502:physiology*; D008863:Microspheres; D009929:Organ Size / Q000502:physiology; D010101:Oxygen Consumption / Q000502:physiology; D005082:Physical Exertion / Q000502:physiology*; D012756:Sheep