Alteration of delta-6 desaturase by vitamin E in rat brain and liver.
delta-6 Desaturase, measured at substrate saturation using linoleic acid, was found to be increased by more than two-fold when the content of vitamin E in brain microsomal membrane suspension was increased (up to 7.5 micrograms/mg membrane protein, i.e. 100 micrograms/g tissue from which microsomes were prepared). In contrast, this activity was reduced by 25% in the liver. This raises the question of the multiple role of vitamin E in membranes, the control of membrane polyunsaturated fatty acids through synthesis, and their protection against peroxidation.
Despret
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INSERM U 26, Hôpital Fernand Widal, Paris, France.
Dinh
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Clément
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Bourre
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JM
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002784:Cholesterol / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology; D044943:Fatty Acid Desaturases / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D005260:Female; D008041:Linoleic Acids / Q000378:metabolism; D050602:Linoleoyl-CoA Desaturase; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014810:Vitamin E / Q000494:pharmacology*
D005231:Fatty Acids, Unsaturated; D008041:Linoleic Acids; D014810:Vitamin E; D000431:Ethanol; D002784:Cholesterol; D044943:Fatty Acid Desaturases; D050602:Linoleoyl-CoA Desaturase