title: Detection and assignment of the glucose signal in 1H NMR difference spectra of the human brain.
abstract: The difference between 1H NMR spectra obtained during eu- and hyperglycemia exhibited well-resolved glucose peaks between 3 and 4 ppm as demonstrated by comparison with solution spectra. Estimated increases were consistent with recent 13C NMR quantitations of intracerebral glucose. Difference spectra were measured in 36-ml volumes from the human brain every 3 min.
authors.affiliation: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06510.
authors.forename: R
authors.initials: R
authors.lastname: Gruetter
authors.forename: D L
authors.initials: DL
authors.lastname: Rothman
authors.forename: E J
authors.initials: EJ
authors.lastname: Novotny
authors.forename: G I
authors.initials: GI
authors.lastname: Shulman
authors.forename: J W
authors.initials: JW
authors.lastname: Prichard
authors.forename: R G
authors.initials: RG
authors.lastname: Shulman
mesh_terms: D001923:Brain Chemistry; D005947:Glucose / Q000032:analysis*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods
chemical_list: D005947:Glucose