[Alcohol drinking behavior based on the neurochemical background. I. Alcohol preference and brain monoamines].
The relationship between voluntary alcohol consumption and monoamine levels was studied in the inbred strains of C57BL/6N, C57BL/6J, A/J, BALB/cA, CBA/N, C3H/He and DBA/2Cr mice; the congenic mouse strain B10. Br/Sg, and the senescence accelerated mouse (SAM P1, SAM P2). C57BL strains exhibited a high alcohol preference whereas the other strains exhibited a low alcohol preference. A clear positive relationship was found between alcohol intake (g/kg/day) and brain norepinephrine (NE) level (r = 0.683, p < 0.05), and a clear negative relationship between alcohol intake and brain serotonin (5HT) level (r = -0.628, p < 0.05). These results suggest that a voluntary alcohol intake in mice is genetically influenced with the brain monoamines, and depend upon the levels of brain NE and 5HT.
Mizohata
K
K
Department of Legal Medicine, Kyoto Prefectural University of Medicine, Japan.
D000428:Alcohol Drinking / Q000523:psychology*; D000818:Animals; D001522:Behavior, Animal; D015306:Biogenic Monoamines / Q000378:metabolism*; D001835:Body Weight; D001921:Brain / Q000378:metabolism*; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA
D015306:Biogenic Monoamines