Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment.
In a screen for transcriptional regulators that control differentiation into the T cell lineage, a complementary DNA was isolated encoding a zinc finger protein (Ikaros) related to the Drosophila gap protein Hunchback. The Ikaros protein binds to and activates the enhancer of a gene encoding an early T cell differentiation antigen, CD3 delta. During development, Ikaros messenger RNA was first detected in the mouse fetal liver and the embryonic thymus when hematopoietic and lymphoid progenitors initially colonize these organs; no expression was observed in the spleen or the bone marrow. The pattern of Ikaros gene expression and its ability to stimulate CD3 delta transcription support the model that Ikaros functions in the specification and maturation of the T lymphocyte.
Georgopoulos
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K
Cutaneous Biology Research Center, Harvard Medical School, Massachusetts General Hospital, Charlestown 02114.
Moore
D D
DD
Derfler
B
B
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D017252:CD3 Complex / Q000235:genetics; D002454:Cell Differentiation / Q000502:physiology; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D004268:DNA-Binding Proteins; D004330:Drosophila / Q000737:chemistry; D029721:Drosophila Proteins; D004742:Enhancer Elements, Genetic; D015870:Gene Expression; D051740:Ikaros Transcription Factor; D007605:Juvenile Hormones / Q000737:chemistry; D008099:Liver / Q000737:chemistry / Q000196:embryology; D051379:Mice; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000032:analysis; D017386:Sequence Homology, Amino Acid; D013601:T-Lymphocytes / Q000166:cytology / Q000502:physiology*; D013950:Thymus Gland / Q000737:chemistry / Q000196:embryology; D014018:Tissue Distribution; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D014158:Transcription, Genetic; D016335:Zinc Fingers / Q000235:genetics / Q000502:physiology*
D017252:CD3 Complex; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D007605:Juvenile Hormones; D012333:RNA, Messenger; D014157:Transcription Factors; C497238:Zfpn1a1 protein, mouse; C061245:hb protein, Drosophila; D051740:Ikaros Transcription Factor; D004247:DNA