Statine based tripeptides as potent inhibitors of HIV-1 replication.
Starting from highly potent HIV-1 protease pepstatine analog inhibitors, we have tried to find the minimum consensus sequence which is necessary to conserve anti-protease potency and antiviral activity. We describe here some statine based tripeptides which exhibit high affinity for the protease and are able to inhibit the reproductive cycle of HIV-1 in MT-4-infected cells.
Fehrentz
J A
JA
Sanofi Recherche, Montpellier, France.
Chomier
B
B
Bignon
E
E
Venaud
S
S
Chermann
J C
JC
Nisato
D
D
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000494:pharmacology*; D002460:Cell Line; D016333:HIV Protease / Q000378:metabolism*; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007700:Kinetics; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects*
D000596:Amino Acids; D017320:HIV Protease Inhibitors; D009842:Oligopeptides; D016333:HIV Protease; C013165:statine