Using the Gompertz-Strehler model of aging and mortality to explain mortality trends in industrialized countries.
Mortality trends in industrialized countries are characterized by declines in vascular disease (ischemic heart disease and stroke) and rises in cancers and degenerative diseases. These trends are typically analyzed by examining each disorder in isolation using the perspective of genetic and environmental influences. However, longitudinal Gompertzian analysis and the Gompertz-Strehler model of aging and mortality as modified by Lestienne suggest that age-specific mortality rates, for both general and disease-specific mortality, are an interrelated deterministic function of aggregate genetic, environmental and competitive influences. Consequently, evolving mortality trends and patterns appear to be influenced by three factors (with deterministic competition being the third factor), rather than just two factors (genetic and environmental) as commonly depicted.
Riggs
J E
JE
Department of Neurology, West Virginia University School of Medicine, Morgantown.
Millecchia
R J
RJ
D000367:Age Factors; D002561:Cerebrovascular Disorders / Q000401:mortality; D006801:Humans; D007221:Industry; D008297:Male; D015233:Models, Statistical; D009026:Mortality / Q000639:trends*; D017202:Myocardial Ischemia / Q000401:mortality; D009369:Neoplasms / Q000401:mortality