title: Involvement of bradykinin-induced [Ca2+]i oscillations in phosphatidylcholine breakdown in K-ras-transformed fibroblasts.
abstract: Bradykinin (BK) induced a biphasic 1,2-diacylglycerol production in both K-ras-transformed (DT) cells and its parent NIH3T3 cells. The first phase was coincident with the transient phosphoinositide turnover and the second sustained phase was derived from hydrolysis of phosphatidylcholine (PC). In DT cells, the PC breakdown was considerably due to phospholipase C and dependent on intracellular calcium oscillations.
authors.affiliation: Department of Biochemistry, Gifu University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Fu
authors.forename: Y
authors.initials: Y
authors.lastname: Okano
authors.forename: Y
authors.initials: Y
authors.lastname: Nozawa
mesh_terms: D016475:3T3 Cells; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D002461:Cell Line, Transformed; D004075:Diglycerides / Q000378:metabolism; D011905:Genes, ras; D007700:Kinetics; D051379:Mice; D008954:Models, Biological; D010713:Phosphatidylcholines / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D011433:Propranolol / Q000494:pharmacology
chemical_list: D004075:Diglycerides; D010713:Phosphatidylcholines; D010743:Phospholipids; D011433:Propranolol; D001920:Bradykinin; D002118:Calcium