title: [A case of pulmonary alveolar proteinosis and disseminated atypical mycobacteriosis complicating chronic myelogenous leukemia].
abstract: A 47-year-old woman with chronic myelogenous leukemia was treated with daily busulfan (total dose approximately 500 mg) from December 1988 to January 1990. The disease thereafter remained stable with no evidence of blastic transformation. In February 1990 she developed productive cough and abnormal acinar lung shadows appeared transiently on her chest X-ray. In October 1990, productive cough and linear and abnormal acinar lung shadows reappeared. Expectorated sputa contained acid-fast bacilli (Gaffky 6, 10). Antituberculous therapy was started, which caused severe liver dysfunction. She was admitted to our hospital for evaluation of abnormal lung shadows. Transbronchial lung biopsy revealed pulmonary alveolar proteinosis with thickening of alveolar septa. The alveolar septal thickening was suspected to be a pathological change following pulmonary alveolar proteinosis. Cultures from sputum, cerebrospinal fluid, and bone marrow aspiration specimens revealed atypical mycobacterium (M. avium complex), and the diagnosis of disseminated atypical mycobacteriosis was established. The pathogenesis of the disseminated atypical mycobacteriosis was considered to be superinfection by mycobacteria.
authors.affiliation: First Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Miyake
authors.forename: S
authors.initials: S
authors.lastname: Ohdama
authors.forename: T
authors.initials: T
authors.lastname: Kumagai
authors.forename: M
authors.initials: M
authors.lastname: Ishikawa
authors.forename: T
authors.initials: T
authors.lastname: Umino
authors.forename: S
authors.initials: S
authors.lastname: Takano
authors.forename: S
authors.initials: S
authors.lastname: Akagawa
authors.forename: N
authors.initials: N
authors.lastname: Aoki
authors.forename: O
authors.initials: O
authors.lastname: Matsubara
mesh_terms: D002066:Busulfan / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000188:drug therapy; D008875:Middle Aged; D015270:Mycobacterium avium-intracellulare Infection / Q000150:complications* / Q000473:pathology; D011649:Pulmonary Alveolar Proteinosis / Q000150:complications* / Q000473:pathology; D015163:Superinfection / Q000150:complications* / Q000473:pathology
chemical_list: D002066:Busulfan