[Experiences with triple antibiotic combination in neonatal infection].
BACKGROUND
In-vitro and clinical efficacy of a combination therapy consisting of 3 antibiotic agents was to be assessed in neonatal septicemia.


METHODS
From 1980 to 1987, 152 newborns with septicemia as proven by blood culture were treated with an initial antibiotic regimen consisting of azlocillin (150 mg/kg bw), cefotaxime (100 mg/kg bw), and tobramycin (5 mg/kg bw).


RESULTS
According to the microbiologic testing, antimicrobic therapy was effective in each of the 152 organisms: 101/152 bacteria were susceptible to all 3 agents; resistance to 1 or 2 of the antibiotics was evident in 33/152 and in 18/152 organisms, respectively. Mortality due to septicemia was 7.2%.


CONCLUSIONS
As no difference was observed in the frequency in which one of the three antibiotic substances was the only effective drug, each of the 3 agents seemed to be necessary for clinical effectiveness of this antibiotic combination.
Paul
T
T
Zentrum Kinderheilkunde und Humangenetik, Medizinische Hochschule Hannover.
Oppermann-Paul
K
K
Peltner
H U
HU
Kallfelz
H C
HC
D001390:Azlocillin / Q000008:administration & dosage*; D001431:Bacteriological Techniques; D002439:Cefotaxime / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000188:drug therapy* / Q000382:microbiology; D008297:Male; D008826:Microbial Sensitivity Tests; D012307:Risk Factors; D018805:Sepsis / Q000188:drug therapy* / Q000382:microbiology; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology; D013290:Streptococcal Infections / Q000188:drug therapy / Q000382:microbiology; D013292:Streptococcus agalactiae / Q000187:drug effects; D014031:Tobramycin / Q000008:administration & dosage*
D001390:Azlocillin; D002439:Cefotaxime; D014031:Tobramycin
Erfahrungen mit einer Dreifachantibiotikakombination bei der neonatalen Sepsis.