[A comparative study of the activity of antihypoxic agents in hemic hypoxia].
Amino derivatives of ortho-benzoquinone (OBQ) were demonstrated to have a protective action in acute toxic hemic hypoxia induced by sodium nitrite given to laboratory animals. This action of OBQ was due to its capacity to activate the recovery of blood oxygen transport function by accelerating the restoration of methemoglobin and determined by their electron-acceptor properties, lipophilicity and NADP-dependent methemoglobin reductase affinity.
Speranskiĭ
S D
SD
Poliukhovich
G S
GS
Speranskaia
E Ch
ECh
Tereshchenko
S M
SM
D000818:Animals; D016227:Benzoquinones / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D000860:Hypoxia / Q000139:chemically induced / Q000188:drug therapy*; D008751:Methylene Blue / Q000627:therapeutic use; D051379:Mice; D011817:Rabbits; D012977:Sodium Nitrite; D013329:Structure-Activity Relationship; D013997:Time Factors
D016227:Benzoquinones; D012977:Sodium Nitrite; D008751:Methylene Blue
Sravnitel'noe izuchenie aktivnosti protivogipoksicheskikh sredstv pri gemicheskoĭ gipoksii.