title: Prenatal diagnosis of the megacystis-megaureter association.
abstract: A total of 11 male neonates with hydronephrosis and a large bladder in utero had the megacystis-megaureter association. Prenatal ultrasound findings included bilateral hydroureteronephrosis; a large, smooth, thin-walled bladder, and normal volume of amniotic fluid. Postnatal studies demonstrated grades 4 to 5 bilateral reflux, a large bladder without obstruction and in 2 infants nonfunction of a kidney or renal moiety. Of 7 infants initially managed nonoperatively 5 have undergone surgery due to persistent reflux or breakthrough urinary infections. The prenatal diagnosis of the megacystis-megaureter association can be suspected with reasonable accuracy. Prompt postnatal continuous antibiotic prophylaxis and uroradiological confirmation allow for nonemergency management of this condition with excellent results.
authors.affiliation: Department of Surgery, Children's Hospital, Boston, Massachusetts.
authors.forename: J
authors.initials: J
authors.lastname: Mandell
authors.forename: R L
authors.initials: RL
authors.lastname: Lebowitz
authors.forename: C A
authors.initials: CA
authors.lastname: Peters
authors.forename: J A
authors.initials: JA
authors.lastname: Estroff
authors.forename: A B
authors.initials: AB
authors.lastname: Retik
authors.forename: B R
authors.initials: BR
authors.lastname: Benacerraf
mesh_terms: D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging*; D006801:Humans; D006869:Hydronephrosis / Q000151:congenital / Q000000981:diagnostic imaging; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D016216:Ultrasonography, Prenatal; D014513:Ureter / Q000002:abnormalities* / Q000000981:diagnostic imaging*; D001743:Urinary Bladder / Q000002:abnormalities* / Q000000981:diagnostic imaging*; D014718:Vesico-Ureteral Reflux / Q000000981:diagnostic imaging