title: [Fructose metabolism disorders and infusions].
abstract: The authors give an account of views regarding the use of non-glucose energy sources in parenteral nutrition during the immediate post-load period/serious operations, severe injuries). Attention is devoted to the metabolic pathway of fructose and its disorders. In hereditary fructose intolerance an infusion of D-fructose or D-glucitol (= sorbitol) can induce life threatening hypoglycaemia (unless glucose is administered concurrently). According to some views, in subjects with this intolerance the organism is threatened also by hepatic and renal failure; their development may be independent on hypoglycaemia. Fructose and D-glucitol (sorbitol) therefore should not be administered by the parenteral route. This view is supported by cases where hereditary fructose intolerance could not be revealed from the case-history and clinical manifestations. Some countries have already eliminated fructose and D-glucitol (sorbitol) from their pharmacopoeias.
authors.affiliation: Biochemický ústav. Lékarská fakulta MU, Brno.
authors.forename: V
authors.initials: V
authors.lastname: Palyza
authors.forename: M
authors.initials: M
authors.lastname: Bocková
mesh_terms: D005526:Food, Formulated / Q000009:adverse effects; D005632:Fructose / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism*; D015318:Fructose Metabolism, Inborn Errors / Q000378:metabolism; D006801:Humans; D010288:Parenteral Nutrition / Q000009:adverse effects; D013012:Sorbitol / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D005632:Fructose; D013012:Sorbitol
vernacular_title: Poruchy metabolismu fruktózy a infúze.