A t(2;3)(q12-13;p24-25) in follicular thyroid adenomas.
We report the cytogenetic analysis of five cases of follicular thyroid adenoma. In two of them, we observed an identical t(2;3)(q12-13;p24-25) as a unique chromosome change. A third case showed a hyperdiploid karyotype with trisomies of chromosomes 7 and 12. Two cases had a normal diploid karyotype. These changes could define subgroups of follicular adenomas endowed with different malignant potential.
Sozzi
G
G
Division of Experimental Oncology A, Istituto Nazionale Tumori, Milan, Italy.
Miozzo
M
M
Cariani
T C
TC
Bongarzone
I
I
Pilotti
S
S
Pierotti
M A
MA
Della Porta
G
G
D000230:Adenocarcinoma / Q000235:genetics*; D000328:Adult; D000782:Aneuploidy; D002881:Chromosomes, Human, Pair 12; D002889:Chromosomes, Human, Pair 2; D002893:Chromosomes, Human, Pair 3; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic; D014314:Trisomy