[Physico-chemical and immunochemical characteristics of molecular forms of carcinoembryonic antigen (CEA) not bound with concanavalin A].
A molecular form of CEA non-binding Con A (CEAnC) was isolated from colon adenocarcinoma metastases in liver as a fraction of CEA having no affinity to Con-A-Sepharose. CEAnC was shown to be immunochemically identical to CEA, but to differ substantially with regard to the amino acid and sugar composition, and structure of the sugar moiety, possibly containing non only N-, but also O-glycosyl carbohydrate chains. The antigens studied were also found to possess different spatial structures. The differences between CEA and CEAnC suggest CEAnC to be a new molecular form of CEA.
Pavlenko
A F
AF
Chikalovets
I V
IV
Kurika
A V
AV
Belogortseva
N I
NI
Ovodov
Iu S
IuS
D000230:Adenocarcinoma / Q000276:immunology / Q000473:pathology; D000596:Amino Acids / Q000032:analysis; D002240:Carbohydrate Sequence; D002272:Carcinoembryonic Antigen / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D002942:Circular Dichroism; D003110:Colonic Neoplasms / Q000276:immunology / Q000473:pathology; D003208:Concanavalin A / Q000378:metabolism*; D006801:Humans; D007120:Immunochemistry; D005779:Immunodiffusion; D008113:Liver Neoplasms / Q000276:immunology / Q000556:secondary; D008969:Molecular Sequence Data
D000596:Amino Acids; D002272:Carcinoembryonic Antigen; D003208:Concanavalin A
Fiziko-khimicheskaia i immunokhimicheskaia kharakteristika molekuliarnoĭ formy rakovo-émbrional'nogo antigena (REA), ne sviazyvaiushcheĭsia s konkanavalinom A.