[The mechanism of action of the bioflavonoid lespeflan and the antihypoxant TB-4 on nitrogen metabolism in animals with acute kidney failure].
The changes in the levels of urea and creatinine caused by the new native preparation lespeflanum and the antihypoxant TB-4 were studied in animal experiments. The agents tested produced a significant hypoazotemic effect in acute renal failure. Lespeflanum showed diuretic and natriuretic effects in healthy animals, elevated plasma aldosterone levels and decreased hepatic arginase activity. There was a normalization of thioldisulfide metabolism in patients treated with lespeflanum and TB-4. The hypoazotemic effect of lespeflanum was due both to its anabolic and anticatabolic effects. Lespeflanum is recommended for wide clinical application to treat patients with chronic renal failure.
Guliaev
V G
VG
Denisenko
P P
PP
Glyzin
V I
VI
Ivanov
Iu I
IuI
Meshchishen
I F
IF
D058186:Acute Kidney Injury / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D004232:Diuretics / Q000494:pharmacology / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use*; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D009318:Natriuresis / Q000187:drug effects; D009584:Nitrogen / Q000097:blood*; D051381:Rats; D013858:Thiobarbiturates / Q000494:pharmacology / Q000627:therapeutic use*
D000975:Antioxidants; D004232:Diuretics; D005419:Flavonoids; D013858:Thiobarbiturates; C029684:thiobarbituric acid; D009584:Nitrogen
K mekhanizmu deĭstviia bioflavonoida lespeflana i antigipoksanta TB-4 na azotistyĭ obmen u zhivotnykh s ostroĭ pochechnoĭ nedostatochnost'iu.