Prolongation of survival in retrovirally induced T cell lymphoma by dietary omega 6 fatty acid.
C57BL/Ka mice were fed diets rich in omega 3 or omega 6 polyunsaturated fatty acids and inoculated with the thymic lymphoma-inducing retrovirus RadLV. Mice receiving the omega 3 diet died significantly sooner than those receiving the omega 6 diet. Of the three known mechanisms by which fatty acids can exert antiviral activity, namely, modification of membrane fluidity, modulation of immune response, and synthesis of metabolites with antiviral activity, the first two can be eliminated in the model under study. It is therefore concluded that differences in survival are due to fatty acid metabolites with distinct antiviral activities.
Potworowski
E
E
Centre de Recherche en Immunologie, Institut Armand-Frappier, Laval, Qc., Canada.
Bischoff
P
P
Oth
D
D
D000818:Animals; D000917:Antibody Formation / Q000276:immunology; D000998:Antiviral Agents / Q000008:administration & dosage*; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D005260:Female; D016399:Lymphoma, T-Cell / Q000178:diet therapy* / Q000209:etiology; D008297:Male; D008560:Membrane Fluidity / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D015996:Survival Rate; D013953:Thymus Neoplasms / Q000178:diet therapy / Q000209:etiology; D013997:Time Factors; D014412:Tumor Virus Infections / Q000150:complications*
D000998:Antiviral Agents; D004042:Dietary Fats, Unsaturated; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated