[Frequency and risk factors associated with metronidazole therapeutic noncompliance].
OBJECTIVE
to determine the frequency and risk factors of non-compliance to oral metronidazole.


METHODS
comparative cross-sectional survey.


METHODS
111 patients who received oral metronidazole. SETTING CHARACTERISTICS: two medical units: one primary level unit and one secondary care unit of the Mexican Institute of Social Security.


METHODS
non-compliance was assessed by home interview and pill count.


RESULTS
frequency of non-compliance was 55%. Risk factors for non-compliance were: female sex (OR = 3.0; p less than 0.05); side effects (OR = 3.1; p less than 0.05); low literacy (OR = 3.75; p less than 0.05). Stratified analysis showed no interaction between variables.


CONCLUSIONS
frequency of non-compliance to metronidazole is high, and could affect the effectiveness of medical care. Female patients with low literacy and who suffer side effects are a high risk group for non-compliance.
Garduño-Espinosa
J
J
Unidad de Investigación Clínica en Enfermedades Infecciosas y Parasitarias, Hospital de Pediatría, Instituto Mexicano del Seguro Social, D.F.
Martínez-García
M C
MC
Fajardo-Gutiérrez
A
A
Ortega-Alvarez
M
M
Alvarez-Espinosa
A
A
Vega-Pérez
V
V
Muñoz-Hernández
O
O
D000284:Administration, Oral; D000328:Adult; D003430:Cross-Sectional Studies; D004522:Educational Status; D005260:Female; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D010349:Patient Compliance; D012307:Risk Factors
D008795:Metronidazole
Frecuencia y factores de riesgo asociados al incumplimiento terapéutico con metronidazol.