Melatonin and jet lag: confirmatory result using a simplified protocol.
This study replicates the alleviation of jet-lag with melatonin in a simplified protocol for eastward flight. At 22-n hr (n is the time-lag between the North American departure point and France), subjects took either melatonin (8 mg, n = 15), or placebo (n = 15) on the day of the return flight and for 3 consecutive days. On day 8, self-ratings significantly discriminated between melatonin and placebo for global treatment efficacy, morning fatigue, and evening sleepiness.
Claustrat
B
B
Service de Radiopharmacie et Radioanalyse, Hôpital Neuro-Cardiologique, Lyon, France.
Brun
J
J
David
M
M
Sassolas
G
G
Chazot
G
G
D000328:Adult; D001143:Arousal / Q000187:drug effects / Q000502:physiology; D002940:Circadian Rhythm / Q000187:drug effects* / Q000502:physiology; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008550:Melatonin / Q000008:administration & dosage* / Q000502:physiology; D014195:Travel
D008550:Melatonin