title: [Experimental evaluation of the allergen activity of a peptide preparation produced from an enzymatic hydrolysate of milk proteins using ultrafiltration].
abstract: Noninbred guinea-pig experiments were performed to investigate specific potential allergenicity of cow milk proteins (CMP) consisting of casein (80%) and serum proteins (20%), of low-molecular peptides (LMP 20/80) produced from CMP 20/80 by enzymatic hydrolysis and ultrafiltration; to evaluate nonspecific effect of test diet CMP 20/80 and LMP 20/80 on anaphylactic response of the animals to ovalbumin and histamine LD50. LMP 20/80 versus CMP 20/80 had a hypoallergenic effect. Potential mechanisms of low anaphylactic sensitivity induced by LMP 20/80 are discussed.
authors.forename: N A
authors.initials: NA
authors.lastname: Malikova
authors.forename: V V
authors.initials: VV
authors.lastname: Krzhechkovskaia
authors.forename: V I
authors.initials: VI
authors.lastname: Kruglik
authors.forename: V K
authors.initials: VK
authors.lastname: Mazo
mesh_terms: D000485:Allergens; D000818:Animals; D006168:Guinea Pigs; D006868:Hydrolysis; D008894:Milk Proteins; D008970:Molecular Weight; D010455:Peptides; D014462:Ultrafiltration
chemical_list: D000485:Allergens; D008894:Milk Proteins; D010455:Peptides
vernacular_title: Eksperimental'naia otsenka allergennogo deĭstviia peptidnogo preparata, poluchennogo iz fermentativnogo gidrolizata belkov moloka s ispol'zovaniem ul'trafil'tratsii.