title: [Coagulation changes during liver resection].
abstract: Thrombin-antithrombin III complex (TAT) and plasminogen activator inhibitor (PAI) were measured during liver resection surgery in 8 patients. TAT and PAI activities of patients under liver resection were compared with those of 11 patients under resection of esophageal carcinoma. TAT activity increased during liver resection (P < 0.001) and reached 14 times (P < 0.001) of its control value in the recovery room. PAI activity was very stable during operation, but increased to twice (P < 0.01) of its control value in the recovery room. TAT activity of patients after liver surgery in the recovery room was (P < 0.05) more than twice of that of patients after esophageal surgery. We conclude that hypercoagulable state occurred during liver resection to a greater degree compared with that observed with esophageal surgery, and that its cause might be liver resection itself.
authors.affiliation: Department of Anesthesiology, Medical College of Oita.
authors.forename: H
authors.initials: H
authors.lastname: Iwasaka
authors.forename: T
authors.initials: T
authors.lastname: Kitano
authors.forename: A
authors.initials: A
authors.lastname: Mizutani
authors.forename: S
authors.initials: S
authors.lastname: Yoshitake
authors.forename: S
authors.initials: S
authors.lastname: Hoashi
authors.forename: T
authors.initials: T
authors.lastname: Noguchi
authors.forename: K
authors.initials: K
authors.lastname: Taniguchi
authors.forename: N
authors.initials: N
authors.lastname: Honda
mesh_terms: D000990:Antithrombin III / Q000378:metabolism*; D016629:Esophagectomy; D006498:Hepatectomy; D006801:Humans; D010447:Peptide Hydrolases / Q000378:metabolism*; D015849:Plasminogen Inactivators / Q000097:blood*
chemical_list: D015849:Plasminogen Inactivators; C046193:antithrombin III-protease complex; D000990:Antithrombin III; D010447:Peptide Hydrolases