Prognosing melanomas: the argyrophilic nucleolar organizer region approach.
Staining of argyrophilic nucleolar organizer regions (AgNORs) is a histological technique that has been assayed on a vast array of cutaneous tumors in order to help distinguish benign from malignant lesions. In a number of papers, malignant melanomas have been found to have a higher number of black nucleolar and extranucleolar dots (i.e. AgNORs) than benign nevi, including Spitz nevus. The technique may be used for prognostic purposes, as a recent paper suggests. Melanomas with more than 3.62 AgNORs/cell have a higher probability to develop metastasis than melanomas with fewer AgNORs. The problems such an apparently simple, fast and reproducible technique may pose are discussed in detail.
Rebora
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Department of Dermatology, University of Genoa, Italy.
D006801:Humans; D008545:Melanoma / Q000175:diagnosis* / Q000648:ultrastructure; D009697:Nucleolus Organizer Region / Q000648:ultrastructure*; D011379:Prognosis; D016622:Silver Staining; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000648:ultrastructure