[The role of fat-soluble vitamins A and E in preventing the biological effects of ionizing radiation in rat tissues].
The lipid peroxidation level and the antioxidant system status have been studied by the amount of alpha-tocopherol and the antioxidant activity of homogenates in the brain, liver, heart and somatic muscle of rats given Vitamins A and E, as physiological additives, before and after gamma-irradiation. It has been shown that a new dynamic balance between the parameters under study is rapidly set up after irradiation, which represents a mechanism of rapid adaptation. The radioprotective effect of alpha-tocopherol is more pronounced than that of Vitamin A (particularly in the brain). In most cases, Vitamin A produces, upon irradiation, an unfavourable effect on antioxidative homeostasis.
Paranich
A V
AV
De Conceçao
A
A
Buga
E V
EV
Kopylov
A V
AV
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000528:radiation effects*; D006321:Heart / Q000187:drug effects* / Q000528:radiation effects*; D008099:Liver / Q000187:drug effects* / Q000528:radiation effects*; D009132:Muscles / Q000187:drug effects / Q000528:radiation effects*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D014801:Vitamin A / Q000494:pharmacology*; D014810:Vitamin E / Q000494:pharmacology*
D011837:Radiation-Protective Agents; D014801:Vitamin A; D014810:Vitamin E
O roli zhirorastvorimykh vitaminov A i E v profilaktike biologicheskikh éffektov ioniziruiushchego izlucheniia v razlichnykh tkaniakh krys.