Control of transcription factors by signal transduction pathways: the beginning of the end.
Signal transduction pathways regulate gene expression by modulating the activity of nuclear transcription factors. The mechanisms that control the activity of two groups of sequence-specific transcription factors, the AP-1 and CREB/ATF proteins, are described. These factors serve as a paradigm explaining the transfer of regulatory information from the cell surface to the nucleus.
Karin
M
M
Department of Pharmacology, University of California, San Diego, School of Medicine, La Jolla 92093-0636.
Smeal
T
T
D051696:Activating Transcription Factors; D000818:Animals; D001798:Blood Proteins / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D010766:Phosphorylation; D016755:Proto-Oncogene Proteins c-jun / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*
D051696:Activating Transcription Factors; D001798:Blood Proteins; D016755:Proto-Oncogene Proteins c-jun; D014157:Transcription Factors