Use of an in vitro absorption model system for predicting sustained release of verapamil.
It is shown that it is possible to characterize sustained release formulations in vitro using not only dissolution data but also an absorption model system. The mean dissolution time (MDT) has been shown to be a suitable parameter for evaluating sustained release formulations in vitro. t1/2 and mean residence time (MRT) have been shown to be convenient pharmacokinetic parameters for characterizing sustained release formulations. For comparing in vitro and in vivo results the quotients MDT normal/MDT retard and MRT normal/MRT retard do seem to be useful.
Neubert
R
R
Department of Pharmacy, Martin-Luther-University, Halle/Saale, Fed. Rep. of Germany.
Fahr
F
F
Mäder
C
C
Lücke
L
L
Fries
G
G
Rostock
G
G
D000328:Adult; D003692:Delayed-Action Preparations; D005260:Female; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D012995:Solubility; D014700:Verapamil / Q000008:administration & dosage / Q000493:pharmacokinetics*
D003692:Delayed-Action Preparations; D014700:Verapamil