[Studies on pharmacokinetics of cisplatin-ethylcellulose microspheres for maxillary arterial embolization in dogs].
This paper reports the preparation and pharmacokinetic studies of DDP-EC-ms. The DDP-EC-ms were infused into the maxillary artery of dogs and DDP were infused into the vein as control. The concentration of DDP in peripheral venous blood and tissue was determined by FAAS. Results showed that the DDP level of DDP-EC-ms in the circulating blood was significantly lower than that in dogs given DDP intravenously. However, a significantly higher DDP concentration in tissues was found in dogs treated with DDP-EC-ms. These facts suggest that maxillary arterial embolization with DDP-EC-ms, which significantly reduced the systematic side effects and increased the level of DDP in the embolized local tissue, could achieve the purpose of targeted cancer therapy.
Wei
S L
SL
School of Pharmaceutical Science, Beijing Medical University.
Qi
X R
XR
Yang
J
J
D000818:Animals; D002482:Cellulose / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D016461:Chemoembolization, Therapeutic; D002945:Cisplatin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004285:Dogs; D008438:Maxillary Artery; D008863:Microspheres
C013517:ethyl cellulose; D002482:Cellulose; D002945:Cisplatin