Auditory brainstem function of the F1 offspring of the cross of CBA/CaJ and AU/SsJ inbred mice.
Inbred strains of laboratory mice have several distinct advantages as models for examining conditions that influence the human auditory system, but the CBA/J mouse which has most often been used as a normal model has recently been found to have several disadvantages. This paper is the first report of the auditory brainstem responses (ABRs) of the F1 offspring of CBA/CaJ and AU/SsJ parents. At midlife, high-frequency ABR thresholds are lower in the F1 than in either parental genotype. Tuning curves obtained by forward masking of the ABR also display heterosis, i.e. they are narrower in the F1 than in either parental strain.
Henry
K R
KR
Department of Psychology, University of California, Davis 95616.
McGinn
M D
MD
Carter
L A
LA
Savoska
E A
EA
D000818:Animals; D001309:Auditory Threshold; D003433:Crosses, Genetic; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005260:Female; D005838:Genotype; D006309:Hearing / Q000502:physiology*; D006579:Heterozygote; D051379:Mice; D008808:Mice, Inbred CBA / Q000235:genetics / Q000502:physiology; D008815:Mice, Inbred Strains / Q000235:genetics* / Q000502:physiology; D008954:Models, Biological; D010033:Otitis Media / Q000235:genetics / Q000503:physiopathology