[The chemoluminescence of the primary focus of a suppurative infection and of isolated neutrophils exposed to dimephosphon].
The influence of dimephosphone at concentrations of 0.001 M-0.75 M on the chemiluminescence of tissues at the focus of purulent infection in the ear of a guinea pig, on the survival rate of the experimental animals injected with the lethal dose of Staphylococcus aureus, as well as on the spontaneous and stimulated chemiluminescence of blood neutrophils in patients with wound infection, was studied. The study showed that different concentrations of dimephosphone oppositely influenced the intensity of the chemiluminescence of neutrophil suspensions and tissues at the focus of infection: low concentrations were found to produce stimulating action and high concentrations, suppressive action. At the highest concentration used in this study (0.75 M) dimephosphone prevented the death of the animals receiving lethal doses of S. aureus.
Ziganshina
L E
LE
Dikovskaia
E S
ES
Belotskiĭ
S M
SM
Studentsova
I A
IA
Blatun
L A
LA
Aleksandrova
L G
LG
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002478:Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D016009:Chi-Square Distribution; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005490:Focal Infection / Q000188:drug therapy* / Q000378:metabolism / Q000401:mortality; D006168:Guinea Pigs; D006801:Humans; D008163:Luminescent Measurements; D008297:Male; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D013207:Staphylococcal Skin Infections / Q000188:drug therapy* / Q000378:metabolism / Q000401:mortality; D014946:Wound Infection / Q000188:drug therapy / Q000378:metabolism
D000276:Adjuvants, Immunologic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D009943:Organophosphorus Compounds; C049638:dimephosphon
Khemiliuminestsentsiia pervichnogo ochaga gnoĭnoĭ infektsii i izolirovannykh neĭtrofilov pri vozdeĭstvii dimefosfona.