title: Changes in polymorphonuclear neutrophil-elastase in pancreatitis.
abstract: In cases of acute and chronic pancreatitis, we measured the amount of polymorphonuclear neutrophil (PMN)-elastase. There was a significantly larger increase in PMN-elastase in patients with pancreatitis than normal adults. Especially, there was a particularly notable increase in amount of PMN-elastase in patients with severe pancreatitis. Furthermore, the peak of PMN-elastase increase throughout the course of the pancreatitis was seen to be 1-2 days after peak increase in pancreatic enzymes. In the experiment in which pancreatic juice and pig pancreatic kallikrein were added to granulocytes in vitro, we recognized a gradual release of PMN-elastase. From these data, we suggested that timely measurements of PMN-elastase are useful to marker of monitoring clinical changes in severe pancreatitis.
authors.affiliation: Department of Internal Medicine, Tonan Hospital, Sapporo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Uehara
authors.forename: K
authors.initials: K
authors.lastname: Gotoh
authors.forename: H
authors.initials: H
authors.lastname: Handa
authors.forename: K
authors.initials: K
authors.lastname: Honjo
authors.forename: A
authors.initials: A
authors.lastname: Hiraŷama
authors.forename: W
authors.initials: W
authors.lastname: Sakamoto
mesh_terms: D000208:Acute Disease; D000328:Adult; D000818:Animals; D002908:Chronic Disease; D006098:Granulocytes / Q000187:drug effects / Q000201:enzymology*; D006801:Humans; D066298:In Vitro Techniques; D007610:Kallikreins / Q000494:pharmacology; D019272:Leukocyte Elastase; D010196:Pancreatic Elastase / Q000097:blood*; D010189:Pancreatic Juice / Q000502:physiology; D010195:Pancreatitis / Q000097:blood / Q000201:enzymology* / Q000503:physiopathology; D012016:Reference Values; D013552:Swine
chemical_list: D007610:Kallikreins; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase