Sulfadiazine therapy for toxoplasmosis in heart transplant recipients decreases cyclosporine concentration.
Toxoplasmosis may cause serious problems after organ transplantation. For treatment of active infection, pyrimethamine combined with a sulfonamide is recommended. During oral sulfadiazine therapy, a significant decrease in cyclosporine concentrations was observed in three heart transplant recipients. This interaction has not been reported previously.
Spes
C H
CH
Medizinische Klinik, Ludwig-Maximilians-Universität, München.
Angermann
C E
CE
Stempfle
H U
HU
Wenke
K
K
Theisen
K
K
D016572:Cyclosporine / Q000097:blood*; D016027:Heart Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood / Q000188:drug therapy*; D013411:Sulfadiazine / Q000627:therapeutic use*; D014123:Toxoplasmosis / Q000097:blood / Q000188:drug therapy* / Q000209:etiology
D013411:Sulfadiazine; D016572:Cyclosporine