Bilateral fetal grafts for Parkinson's disease: 22 months' results.
Five patients with severe Parkinson's disease underwent bilateral multiple graft implants of nondissociated fetal mesodiencephalic tissues. Graft implantation was performed in China following CT-guided stereotactic placement of a novel delivery system. Follow-up has demonstrated substantially reduced levodopa requirements and clinical improvements of motor, postural functions and reduction of freezing and on-off phenomenon. PET utilizing [18F]-dopa, at 14 months in the first case, suggested graft-induced restoration of dopaminergic transmission in the striatum.
Iacono
R P
RP
Department of Neurosurgery, Hua Shan Hospital, Shanghai, ROC.
Tang
Z S
ZS
Mazziotta
J C
JC
Grafton
S
S
Hoehn
M
M
D016380:Brain Tissue Transplantation / Q000379:methods / Q000502:physiology; D004027:Diencephalon / Q000637:transplantation*; D016332:Fetal Tissue Transplantation / Q000379:methods / Q000502:physiology; D005500:Follow-Up Studies; D007839:Functional Laterality; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery*; D013238:Stereotaxic Techniques; D013997:Time Factors
D007980:Levodopa