Evaluation of experimental early acute cerebral ischemia before the development of edema: use of dynamic, contrast-enhanced and diffusion-weighted MR scanning.
The ability of dynamic, contrast-enhanced, magnetic susceptibility-weighted scanning to delineate early experimental acute cerebral infarction was compared with that of heavily T2-weighted and diffusion-weighted spin echo scanning. Spontaneously hypertensive rats, which had undergone right middle cerebral artery occlusion, were studied from 15 min to 3 h post ligation on a 1.5-T clinical whole-body imager. In contrast to the diffusion- and T2-weighted spin echo scans, the dynamic, contrast-enhanced technique clearly and consistently delineated the nonperfused regions as early as 15 min post ligation.
Finelli
D A
DA
Department of Radiology, University Hospitals of Cleveland/Case Western Reserve School of Medicine, Ohio 44106.
Hopkins
A L
AL
Selman
W R
WR
Crumrine
R C
RC
Bhatti
S U
SU
Lust
W D
WD
D000208:Acute Disease; D000818:Animals; D001929:Brain Edema / Q000175:diagnosis*; D002545:Brain Ischemia / Q000175:diagnosis*; D003287:Contrast Media; D003911:Dextrans; D004338:Drug Combinations; D052203:Ferrosoferric Oxide; D005682:Gadolinium; D019786:Gadolinium DTPA; D007501:Iron; D008279:Magnetic Resonance Imaging / Q000379:methods; D058185:Magnetite Nanoparticles; D008536:Meglumine; D009942:Organometallic Compounds; D010087:Oxides; D004369:Pentetic Acid; D011107:Polylysine / Q000031:analogs & derivatives; D051381:Rats; D011918:Rats, Inbred SHR; D013997:Time Factors
D003287:Contrast Media; D003911:Dextrans; D004338:Drug Combinations; D058185:Magnetite Nanoparticles; D009942:Organometallic Compounds; D010087:Oxides; C068674:polylysine-(Gd-DTPA); D011107:Polylysine; D008536:Meglumine; D004369:Pentetic Acid; D005682:Gadolinium; D007501:Iron; C065507:ferumoxides; D019786:Gadolinium DTPA; D052203:Ferrosoferric Oxide