Failure of beta-amyloid protein fragment 25-35 to cause hippocampal damage in the rat.
Considerable excitement has been generated as of late over reports that fragments of the amyloid precursor protein can be neurotoxic both in vivo and in vitro. In this brief report we study the neurotoxicity of the fragment corresponding to amino acids 25-35 of the beta-amyloid protein in the hippocampus in vivo. Under the conditions studied, we do not observe any evidence of consistent, dose-related damage above that seen with vehicle alone.
Stein-Behrens
B
B
Department of Biological Sciences, Stanford University, CA 94305.
Adams
K
K
Yeh
M
M
Sapolsky
R
R
D016229:Amyloid beta-Peptides / Q000633:toxicity*; D000818:Animals; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology*; D006651:Histocytochemistry; D066298:In Vitro Techniques; D008297:Male; D010446:Peptide Fragments / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013238:Stereotaxic Techniques
D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C074636:amyloid beta-protein (25-35)