title: Unsuccessful methotrexate treatment of a tubal pregnancy with a live embryo.
abstract: Two cases with unsuccessful local and systemic methotrexate (MTX) therapy of tubal pregnancy with fetal heart rate activity are reported. The three modes of therapy, the first with local potassium chloride solution injection, the second with local MTX injection, and the third with systemic MTX injection, failed in the resolution of viable ectopic pregnancy. Therapy of MTX in cases of tubal pregnancy with demonstrable fetal heart rate beats, should be reconsidered.
authors.affiliation: Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Bider
authors.forename: G
authors.initials: G
authors.lastname: Oelsner
authors.forename: D
authors.initials: D
authors.lastname: Admon
authors.forename: D
authors.initials: D
authors.lastname: Levran
authors.forename: M
authors.initials: M
authors.lastname: Goldenberg
authors.forename: S
authors.initials: S
authors.lastname: Mashiach
mesh_terms: D000328:Adult; D005260:Female; D005328:Fetal Viability; D006340:Heart Rate, Fetal; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use*; D011189:Potassium Chloride / Q000627:therapeutic use; D011247:Pregnancy; D011274:Pregnancy, Tubal / Q000188:drug therapy*
chemical_list: D011189:Potassium Chloride; D008727:Methotrexate