title: Studies with enteroaggregative Escherichia coli in the gnotobiotic piglet gastroenteritis model.
abstract: Two strains of enteroaggregative Escherichia coli of human origin fed to gnotobiotic piglets caused diarrhea or death in the majority of them. Histological examination revealed moderate hyperemia of the distal small intestine and cecum, swelling of small intestinal villi, and layers of aggregated bacteria stacked together in a mucus gel-like matrix overlying intact epithelium. These findings confirm that enteroaggregative E. coli strains produce distinctive intestinal lesions different from those caused by other major categories of diarrheagenic E. coli.
authors.affiliation: Department of Microbiology, Royal Children's Hospital, Melbourne, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Tzipori
authors.forename: J
authors.initials: J
authors.lastname: Montanaro
authors.forename: R M
authors.initials: RM
authors.lastname: Robins-Browne
authors.forename: P
authors.initials: P
authors.lastname: Vial
authors.forename: R
authors.initials: R
authors.lastname: Gibson
authors.forename: M M
authors.initials: MM
authors.lastname: Levine
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004926:Escherichia coli / Q000472:pathogenicity*; D005759:Gastroenteritis / Q000209:etiology* / Q000473:pathology; D005856:Germ-Free Life; D007082:Ileum / Q000473:pathology / Q000648:ultrastructure; D013552:Swine