Insulin dependent diabetes mellitus accompanied by nephrocalcinosis and renal failure.
Renal failure was found in a five-year-old patient who had been treated with insulin since he was diagnosed as having insulin dependent diabetes mellitus (IDDM) at 3 years of age. Laboratory data showed that his renal failure was caused by a renal tubular dysfunction. The autopsy findings of his pancreas were compatible with those of IDDM. The kidneys were atrophied with an innumerable number of crystals in the proximal tubuli. Staining by Kossa indicated that the crystals contained calcium salt. The calcium content of his kidneys was significantly higher than that of control. The nephrocalcinosis seems to be caused by hypercalciuria associated with IDDM.
Kodama
H
H
Department of Pediatrics, Jichi Medical School, Tochigi, Japan.
Kuramatsu
T
T
Yanagisawa
M
M
Uchiya
T
T
Takahashi
A
A
D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005500:Follow-Up Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology* / Q000473:pathology; D008297:Male; D009397:Nephrocalcinosis / Q000209:etiology* / Q000473:pathology