Enhanced luminescent assays for hepatitis markers: assessment of post vaccine responses.
A range of solid phase immunoassays have been developed using enhanced chemiluminescence to provide a signal which can be measured in a qualitative or quantitative manner. The "Amerlite" anti-HBs assay has been used routinely to test more than 3000 post-vaccine anti-HBs levels. The results show that 5% of vaccinees are non-responders, but that more than 30% produce antibody levels greater than 1000 mIU/ml.
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Regional Virus Laboratory, Birmingham, West Midlands, England, U.K.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000917:Antibody Formation; D015415:Biomarkers; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000097:blood*; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D011933:Reagent Kits, Diagnostic; D014611:Vaccination
D015415:Biomarkers; D006510:Hepatitis B Antibodies; D011933:Reagent Kits, Diagnostic