title: Effect of ethylenediamine di-o-hydroxyphenylacetic acid and transferrin on the growth of some bacterial strains in vitro.
abstract: The ability of some bacterial strains to obtain iron from ethylenediamine di-o-hydroxyphenylacetic acid (EDDA) or iron-free transferrin, and accordingly grow in their presence, was studied. Growth of Staphylococcus aureus and Yersinia pseudotuberculosis was inhibited by EDDA or by iron-free transferrin. Growth of Streptococcus faecalis, however, was inhibited by iron-free transferrin, but not by EDDA. The other bacterial strains, i.e.; Escherichia coli, Salmonella typhimurium and Shigella dysenteriae were able to grow both in the presence of EDDA or iron-free transferrin. All of the above bacterial strains grow in the presence of iron-saturated transferrin which was not able to bind the iron of the medium and accordingly left the iron of the medium available to them.
authors.affiliation: Botany and Microbiology Department, College of Science, King Saud University, Riyadh, Saudi Arabia.
authors.forename: A A
authors.initials: AA
authors.lastname: Salamah
mesh_terms: D001419:Bacteria / Q000187:drug effects / Q000254:growth & development*; D005029:Ethylenediamines / Q000494:pharmacology*; D007501:Iron / Q000378:metabolism; D014168:Transferrin / Q000494:pharmacology*
chemical_list: D005029:Ethylenediamines; D014168:Transferrin; C011813:ethylenediamine-N,N'-bis(2-hydroxyphenylacetic acid); D007501:Iron