title: The progressive changes of neuronal activities of the nigral dopaminergic neurons upon withdrawal from continuous infusion of cocaine.
abstract: Sensitivity of the nigral dopamine neurons to intravenous apomorphine was examined in rats pretreated with continuous cocaine or saline for two weeks. One day after withdrawal from pretreatment, a subsensitivity was observed while a supersensitivity was found on day 7, along with a significant increase in the baseline firing rates. In humans, an increased sensitivity of dopamine soma/dendritic autoreceptors may partly account for the symptomatology associated with the intermediate phase of withdrawal from cocaine binges.
authors.affiliation: Department of Psychiatry, Duke University Medical Center, Durham, NC 27710.
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: T H
authors.initials: TH
authors.lastname: Lee
authors.forename: E H
authors.initials: EH
authors.lastname: Ellinwood
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage*; D003042:Cocaine / Q000008:administration & dosage*; D004298:Dopamine / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*; D013378:Substantia Nigra / Q000166:cytology / Q000187:drug effects*
chemical_list: D003042:Cocaine; D001058:Apomorphine; D004298:Dopamine