Hepatoprotective effects of lobenzarit disodium on acetaminophen-induced liver damage in mice.
We have studied the effects of the immunomodulator drug lobenzarit in the model of acute hepatotoxicity induced by a high oral dose (600 mg/kg) of acetaminophen in mice. Lobenzarit at doses of 25, 50 and 100 mg/kg i.p. decreased significantly the activity of alanine aminotransferase in serum, which was increased by acetaminophen alone, and increased the concentration of reduced glutathione in mice liver, which is depleted by acetaminophen. Lobenzarit also reduced liver damage induced by acetaminophen in mice, which was observed by electron microscopy. The hepatoprotective effects of lobenzarit were dose-dependent and they were produced when lobenzarit was administered 30 min before acetaminophen or 2 and 4 h after it. It is concluded that lobenzarit exerts some effects which resemble those of an antidote of acetaminophen such as N-acetylcysteine.
González
R
R
Department of Pharmacology, National Center for Scientific Research, Havana, Cuba.
Pascual
C
C
Ancheta
O
O
Carreras
B
B
Remírez
D
D
Pellón
R
R
D000082:Acetaminophen / Q000037:antagonists & inhibitors* / Q000633:toxicity; D000410:Alanine Transaminase / Q000097:blood / Q000187:drug effects; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D004305:Dose-Response Relationship, Drug; D005978:Glutathione / Q000378:metabolism; D008107:Liver Diseases / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D010084:Oxidation-Reduction / Q000187:drug effects; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
D062367:ortho-Aminobenzoates; D000082:Acetaminophen; C015735:lobenzarit; D000410:Alanine Transaminase; D005978:Glutathione