title: Changing pattern of gastric cancer in Oxfordshire.
abstract: This study compares the incidence rates of histologically confirmed gastric carcinoma in Oxfordshire in two five year periods (1960-64, 1984-88). Data were available for 215 patients in the first period, and 200 in the second. The overall incidence fell from 18/100,000 to 15/100,000 but when analysed for site, the incidence of antral tumours fell from 10 to 4.5/100,000. In contrast, there was an increase from 2.8 to 5.2/100,000 of tumours of the cardia. These changes were more pronounced in men. There was a marked association between smoking and tumours of the cardia (relative risk 4.5). Helicobacter pylori was associated with 37.5% of tumours in the 1960s series compared with 25% in the later series. The changing patterns of incidence of gastric carcinoma may, in part, be related to changes in smoking habits and perhaps a change in incidence of H pylori infection.
authors.affiliation: Gastroenterology Unit, Radcliffe Infirmary, Oxford.
authors.forename: E
authors.initials: E
authors.lastname: Rios-Castellanos
authors.forename: F
authors.initials: F
authors.lastname: Sitas
authors.forename: N A
authors.initials: NA
authors.lastname: Shepherd
authors.forename: D P
authors.initials: DP
authors.lastname: Jewell
mesh_terms: D000367:Age Factors; D000368:Aged; D002299:Cardia; D004739:England / Q000453:epidemiology; D005260:Female; D016481:Helicobacter Infections / Q000150:complications; D016480:Helicobacter pylori; D006801:Humans; D015994:Incidence; D007414:Intestinal Neoplasms / Q000556:secondary; D008297:Male; D011706:Pyloric Antrum; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000209:etiology