[Advantages of 24-hour ambulatory blood pressure monitoring for the assessment of dose-effect relations and dose-equivalency].
Because of the high variability of blood-pressure, clinical studies using casual measurements require rather large numbers of patients for assessment of pharmacologic efficacy. By the use of blood-pressure monitoring over 24 hours this number can be dramatically reduced. Additional benefits are the precise determination of dose-effect relationships and the more accurate estimate of the response-rate. Comparing two retarded galenic forms of Verapamil we show that even dose-equivalence can be studied with this type of blood-pressure recording.
Kraft
K
K
Medizinische Universitätspoliklinik Bonn.
Vetter
H
H
D001794:Blood Pressure / Q000187:drug effects*; D001795:Blood Pressure Determination / Q000379:methods*; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008991:Monitoring, Physiologic / Q000379:methods*; D013810:Therapeutic Equivalency; D014700:Verapamil / Q000008:administration & dosage*
D003692:Delayed-Action Preparations; D014700:Verapamil
Vorteile des Einsatzes der ambulanten 24-Std.-Blutdruckmessung zur Ermittlung von Dosis-Wirkungs-Beziehungen und Aquivalenzdosierungen.