[Lipid peroxidation as a possible mechanism of erythrocyte damage in patients with chronic kidney failure on hemodialysis].
Ten patients with chronic renal failure (CRF) treated by hemodialysis (HD) were examined. All the patients demonstrated remarkable anemia. The red blood cell count was (2.7 +/- 0.2) x 10(12)/I the concentration of hemoglobin 79.5 +/- 5.6 g/l, on the average, hematocrit 23.2 +/- 1.8%. The content of malonic dialdehyde in the patients' red blood cells was far greater than in controls, amounting to 132% (per 1 ml of hemolysate), 134% (per 1 mg of protein) (p < 0.05). Catalase and glutathione peroxidase activity in the patients' red blood cells did not differ from that in controls. Superoxide dismutase activity reduced by 43% as compared to that in donors (p < 0.001). The authors review possible mechanisms of lipid peroxidation (LPO) and a decrease of antioxidant defense in red blood cells of CRF patients on hemodialysis. It is concluded that activation of LPO processes and the decrease of antioxidant defense produce a noticeable destructive effect on the integrity of the red blood cell membrane. They also influence the development of hemolysis.
Balashova
T S
TS
Rud'ko
I A
IA
Ermolenko
V M
VM
Tsalenchuk
Ia P
IaP
Kubatiev
A A
AA
D000328:Adult; D000740:Anemia / Q000097:blood / Q000209:etiology; D000975:Antioxidants; D004912:Erythrocytes / Q000737:chemistry / Q000201:enzymology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000628:therapy; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D006435:Renal Dialysis
D000975:Antioxidants; D008315:Malondialdehyde
Perekisnoe okislenie lipidov kak vozmozhnyĭ mekhanizm povrezhdeniia éritrotsitov u bol'nykh s khronicheskoĭ pochechnoĭ nedostatochnost'iu v usloviiakh gemodializa.