title: Cholecystokinin, a satiety signal in newborn infants?
abstract: This study was undertaken in order to describe circulating glucose and cholecystokinin (CCK) concentrations in relation to the spontaneous feeding behavior of the human newborn infant. Eighty-three, healthy, 3-days-old infants were studied in connection with breast feeding. Blood samples from the infants were cross-sectionally collected before feeding, 5 and 10 min after the start of sucking, and after the infants had sucked ad libitum. Before feeding, the infants presented a typical "hunger behavior", which changed in connection with breast feeding into a pattern associated with satiety. A significant increase in the plasma CCK concentration was found, 5 min (P = 0.004) and 10 min (P = 0.02) after the start of sucking, as well as after feeding (P = 0.04). Furthermore, a positive correlation between the CCK concentration and the volume of ingested milk was found 10 min after the start of sucking, when 91% of of the volume of milk had been ingested; Rs = 0.51, n = 19, P < 0.02. However, no change was found in the glucose concentration in connection with breast feeding. It is concluded that CCK may be important as a satiety factor in the regulation of food intake in the newborn infant.
authors.affiliation: Department of Pediatrics KS-St Göran, Karolinska Hospital, Stockholm, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Marchini
authors.forename: A
authors.initials: A
authors.lastname: Lindén
mesh_terms: D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose; D001942:Breast Feeding; D002766:Cholecystokinin / Q000097:blood*; D005247:Feeding Behavior; D006801:Humans; D006815:Hunger; D007231:Infant, Newborn; D009129:Muscle Tonus
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D002766:Cholecystokinin