Carbamazepine neurotoxic reaction after administration of diltiazem.
A patient with epilepsy controlled by carbamazepine developed a carbamazepine neurotoxic reaction after being given an increased dosage of diltiazem hydrochloride as adjunctive therapy. Abrupt withdrawal of diltiazem reduced the circulating carbamazepine concentration and resulted in an epileptic attack. Awareness of the interaction between diltiazem and carbamazepine and careful monitoring of carbamazepine blood levels is recommended to prevent the dangerous neurotoxic effect associated with this combination.
Maoz
E
E
Department of Medicine D, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Grossman
E
E
Thaler
M
M
Rosenthal
T
T
D002220:Carbamazepine / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D004110:Diltiazem / Q000009:adverse effects* / Q000627:therapeutic use; D004347:Drug Interactions; D004827:Epilepsy / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D008875:Middle Aged; D009422:Nervous System Diseases / Q000097:blood / Q000139:chemically induced*; D013375:Substance Withdrawal Syndrome / Q000097:blood
D002220:Carbamazepine; D004110:Diltiazem