title: Gadolinium-enhanced magnetic resonance imaging of the central nervous system in systemic lupus erythematosus.
abstract: Gadolinium (Gd)-DTPA enhanced magnetic resonance imaging (MRI) was performed in 15 systemic lupus erythematosus patients with past (12) or present (3) features suggesting central nervous system (CNS) involvement. Symptomatic Gd-DTPA enhancing lesions were seen in 2 patients, and immunosuppressive treatment was associated with a rapid reversal of enhancement. The pattern of enhancement was different from that usually seen in multiple sclerosis. Gd-DTPA enhanced MRI may sometimes be useful in demonstrating the activity of CNS lupus.
authors.affiliation: Institute of Neurology, London, UK.
authors.forename: D H
authors.initials: DH
authors.lastname: Miller
authors.forename: N
authors.initials: N
authors.lastname: Buchanan
authors.forename: G
authors.initials: G
authors.lastname: Barker
authors.forename: S P
authors.initials: SP
authors.lastname: Morrissey
authors.forename: B E
authors.initials: BE
authors.lastname: Kendall
authors.forename: P
authors.initials: P
authors.lastname: Rudge
authors.forename: M
authors.initials: M
authors.lastname: Khamashta
authors.forename: G R
authors.initials: GR
authors.lastname: Hughes
authors.forename: W I
authors.initials: WI
authors.lastname: McDonald
mesh_terms: D000293:Adolescent; D000328:Adult; D001812:Blood-Brain Barrier / Q000502:physiology; D001921:Brain / Q000473:pathology*; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D004369:Pentetic Acid; D013116:Spinal Cord / Q000473:pathology*
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA