[Observation of the morphological genesis of pleural mesothelioma induced by asbestos in rats].
In order to observe the lesions of pleural mesothelia caused by asbestos, we injected asbestos fiber into the pleural cavity of Wistar rats. The result showed that there Was an obvious process for the morphological genesis of mesothelioma. Simple hyperplasia and stratified pleomorphic hyperplasia of mesothelial cells were found on the 30th and 106th day after the injection of asbestos fiber, respectively. The benign and malignant mesotheliomas were noted on the 300th day. Meanwhile, a two-way differentiation may be observed in the process of mesothelial hyperplasia.
Wang
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C
Luo
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S
Liu
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X
D000818:Animals; D001194:Asbestos / Q000009:adverse effects*; D004848:Epithelium / Q000473:pathology; D006965:Hyperplasia / Q000473:pathology; D008654:Mesothelioma / Q000473:pathology*; D010994:Pleura / Q000473:pathology; D010997:Pleural Neoplasms / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar
D001194:Asbestos