title: Gas chromatographic profiles of plasma total lipids as indicators of dietary history. Correlation with carbohydrate and alcohol intake based on 24-h dietary recall.
abstract: Quantitative gas chromatographic estimates of the major lipid classes and molecular species in fasting plasma were correlated with total carbohydrate, starch, fibre, sucrose and alcohol intake based on 24-h dietary recall. Spearman coefficients (rs) and tests of significance (P) were obtained for groups of 775 males and 471 females aged 20-59 years from a Toronto-McMaster Lipid Research Clinics Population Study. The most significant correlations varying from rs 0.1 to 0.2 and P 0.001 to 0.0005 (n = 400-773) were between increased intake of alcohol and increased ratios of C50/C54 triacylglycerols, C34/C36 phosphatidylcholines and phosphatidylcholine/free cholesterol (PC/FC) of plasma. Increase in total dietary carbohydrate, starch and fibre correlated with decreasing C50/C54 triacylglycerol, C34/C36 phosphatidylcholine and PC/FC ratios (rs = -0.1-0.2; P less than 0.002-0.04; n = 400-773). In contrast, consumption of high levels of alcohol was associated with increasing C50/C54 triacylglycerol, C34/C36 phosphatidylcholine and PC/FC ratios. A high intake of alcohol (50-150 ml per day) distinguished itself from other simple carbohydrate-induced lipid profiles by its marked effect on increased C50/C52 triacylglycerol and PC/FC ratio.
authors.affiliation: Banting and Best Department of Medical Research, University of Toronto, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Kuksis
authors.forename: J J
authors.initials: JJ
authors.lastname: Myher
authors.forename: K
authors.initials: K
authors.lastname: Geher
authors.forename: W C
authors.initials: WC
authors.lastname: Breckenridge
authors.forename: T
authors.initials: T
authors.lastname: Feather
authors.forename: V
authors.initials: V
authors.lastname: McGuire
authors.forename: J A
authors.initials: JA
authors.lastname: Little
mesh_terms: D000328:Adult; D002784:Cholesterol / Q000097:blood; D002849:Chromatography, Gas / Q000379:methods*; D002940:Circadian Rhythm; D004040:Dietary Carbohydrates / Q000378:metabolism* / Q000494:pharmacology; D000431:Ethanol / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010713:Phosphatidylcholines / Q000097:blood; D013213:Starch / Q000378:metabolism; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D004040:Dietary Carbohydrates; D008055:Lipids; D010713:Phosphatidylcholines; D014280:Triglycerides; D000431:Ethanol; D013213:Starch; D002784:Cholesterol