title: Kallikrein-like activity in the bronchoalveolar lavage (BAL) fluid of sensitized, challenged guinea-pigs.
abstract: Sensitization and challenge of guinea-pig airways with aerosols of ovalbumin solution administered through an endotracheal tube leads to a significant increase in kallikrein-like enzyme activity in bronchoalveolar lavage (BAL) fluid. This increase is present up to six hours after challenge and may be related to changes in airways resistance that persist for similar periods.
authors.affiliation: Clinical Pharmacology, Southampton General Hospital, England.
authors.forename: R L
authors.initials: RL
authors.lastname: Featherstone
authors.forename: J E
authors.initials: JE
authors.lastname: Parry
authors.forename: M K
authors.initials: MK
authors.lastname: Church
mesh_terms: D000336:Aerosols; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000378:metabolism*; D004342:Drug Hypersensitivity / Q000503:physiopathology*; D006168:Guinea Pigs; D007610:Kallikreins / Q000378:metabolism*; D010047:Ovalbumin / Q000008:administration & dosage; D012016:Reference Values; D012137:Respiratory System / Q000503:physiopathology*
chemical_list: D000336:Aerosols; D010047:Ovalbumin; D007610:Kallikreins