title: Effectiveness of magnesium pidolate in the prophylactic treatment of primary dysmenorrhea.
abstract: To evaluate Magnesium (Mg) effectiveness in the treatment of primary dysmenorrhea, 30 volunteer dysmenorrheic women of mean age 22.6 years were selected from the out-patients of the Dept. of Obstetrics and Gynaecology of the University of Parma during the period January-December 1989. Patients affected by secondary dysmenorrhea were excluded from the trial. The women considered were asked to self-evaluate their menstrual pain for 6 subsequent cycles using the VAS (Visual Analogue Scale). In the first cycle, as control, no drug was administered; in the following ones, every woman was given 4.5 mg oral Mg Pidolate in 3 administrations daily, from the 7th day preceding the onset of menses till the 3rd day of menstruation. Data were statistically analyzed. In Mg-treated cycles compared with the control one, first day dysmenorrhea progressively decreased, with a significant drop (p < 0.05) from the 1st to the 6th cycle. A similar trend, but not statistically significant, was seen for the 2nd and 3rd day of cycle. No side effect was remarked. These data suggest Mg administration to be a reliable therapy of primary dysmenorrhea.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Parma.
authors.forename: L
authors.initials: L
authors.lastname: Benassi
authors.forename: F P
authors.initials: FP
authors.lastname: Barletta
authors.forename: L
authors.initials: L
authors.lastname: Baroncini
authors.forename: D
authors.initials: D
authors.lastname: Bertani
authors.forename: F
authors.initials: F
authors.lastname: Filippini
authors.forename: L
authors.initials: L
authors.lastname: Beski
authors.forename: A
authors.initials: A
authors.lastname: Nani
authors.forename: P
authors.initials: P
authors.lastname: Tesauri
authors.forename: G
authors.initials: G
authors.lastname: Tridenti
mesh_terms: D000328:Adult; D004412:Dysmenorrhea / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008275:Magnesium Deficiency / Q000150:complications; D008598:Menstruation; D010146:Pain / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D011761:Pyrrolidonecarboxylic Acid / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D011761:Pyrrolidonecarboxylic Acid