Noninvasive in vivo 13C-NMR spectroscopy of a 13C-labeled xenobiotic in the rat.
This study demonstrates that the xenobiotic product, 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloro-3-13C-propane can be monitored in the liver of an intact animal by in vivo 13C surface coil NMR spectroscopy after intraperitoneal administration. The carbon-13 label could be detected after a single dose of only 200 mg/kg of the product. The intrahepatic changes of the signal intensity of the labeled product were monitored as a function of time. No signals corresponding to metabolites could be detected.
Lanens
D
D
Research Group for Biomedical NMR, University of Antwerp, Wilrijk, Belgium.
Muller
H J
HJ
Van de Vyver
F
F
de Cock-Bunning
T
T
Spanoghe
M
M
Van der Linden
A
A
Mulder
G J
GJ
Dommisse
R
R
Lugtenburg
J
J
D000818:Animals; D002250:Carbon Radioisotopes; D005260:Female; D007274:Injections, Intraperitoneal; D008099:Liver / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008939:Mitotane / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D015262:Xenobiotics / Q000008:administration & dosage* / Q000032:analysis
D002250:Carbon Radioisotopes; D015262:Xenobiotics; D008939:Mitotane; C051076:mitometh