title: [The hypometabolic effect of the blood plasma from a hibernating suslik Citellus undulatus. Neokyotorphin activates cardiac and respiratory activities in the suslik during arousal from hibernation].
abstract: The effect of intraabdominal injection of the blood serum from ground squirrels Citellus undulatus obtained at various stages of the baut has been studied on the level of oxygen consumption in albino mice. The strongest hypometabolic effect exhibited the blood plasma from animals at the beginning of the baut. The onset of baut was used in further experiments on C. undulatus for investigation of activating effects of neokiotorphin (Thr-Ser-Lys-Tyr-Arg) which was earlier found in the brain of the ground squirrel. It was shown that intraabdominal injection of this peptide to hibernating animals facilitates their arousal stimulating both the cardiac activity and respiration. The strongest effect was noted with neokiotorphin of [D-Ser] 2-modification which is more stable to proteolysis.
authors.forename: D A
authors.initials: DA
authors.lastname: Ignat'ev
authors.forename: G S
authors.initials: GS
authors.lastname: Sukhova
authors.forename: V I
authors.initials: VI
authors.lastname: Zagnoĭko
authors.forename: V P
authors.initials: VP
authors.lastname: Sukhov
authors.forename: V I
authors.initials: VI
authors.lastname: Sviriaev
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects / Q000502:physiology; D004723:Endorphins / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006605:Hibernation / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D010101:Oxygen Consumption / Q000187:drug effects / Q000502:physiology; D010507:Periodicity; D010949:Plasma / Q000502:physiology*; D012119:Respiration / Q000187:drug effects* / Q000502:physiology; D012589:Sciuridae / Q000097:blood*; D013997:Time Factors
chemical_list: D004723:Endorphins; C036450:neo-kyotorphin
vernacular_title: Gipometabolicheskiĭ éffekt plazmy krovi giberniruiushchego suslika Citellus undulatus. Neokiotorfin aktiviruet deiatel'nost' serdtsa i dykhaniia suslika pri vykhode iz spiachki.