Effect of endothelin (ET)-1, ET-3 and ET-(16-21) on the isolated and perfused rat kidney from normotensive and spontaneously hypertensive rats.
We have investigated the effect of endothelin (ET)-1, ET-3 and ET-(16-21) on isolated and perfused rat kidney (IPK). ET-1 and ET-3 produced a similar dose-dependent increase in perfusion pressure of IPK, while ET-(16-21) was completely inactive. The ET-1 effects were greater in spontaneously hypertensive rats (SHR) as compared to normotensive rats (WKYR), whereas the ET-3 effects were greater in the SHR group only at the lowest doses. The pressure response of IPK induced by ET-1 was partially modified by prior application of the nitric oxide synthetase inhibitor L-nitroarginine in both WKYR and SHR.
Evangelista
S
S
Pharmacology Department, Istituto Farmacobiologico Malesci S.p.A., Firenze, Italy.
Maggi
C A
CA
Castellucci
A
A
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D016232:Endothelins / Q000494:pharmacology* / Q000502:physiology; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology*; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology; D010477:Perfusion; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012079:Renal Circulation / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects
D016232:Endothelins; D010446:Peptide Fragments; C061533:endothelin (16-21)