title: Endocrine events associated with endometrial function and conceptus development in cattle.
abstract: Regulation and timing of luteolysis during the bovine oestrous cycle is controlled by the initiation and length of progesterone stimulation. Results have demonstrated that early administration of progesterone shortens the interoestrous interval in the ewe and cow, and removal of progesterone stimulation through a progesterone receptor antagonist delays luteolysis in sheep. Current data suggest that down-regulation of progesterone receptors in the uterine epithelium may initiate events involved in the synthesis and release of prostaglandin F2 alpha (PGF2 alpha) for luteolysis. Progesterone is also involved in the stimulation of the uterine secretions that regulate conceptus growth and the release of the bovine trophoblast protein-1 (bTP-1) necessary for inhibiting endometrial PGF2 alpha release. Conceptus secretion of bTP-1, a Type I trophoblast interferon, increases the concentration of the cellular enzyme 2',5'-oligoadenylate synthetase within the endometrium. The biological role of 2',5'-oligoadenylate synthetase in the establishment of pregnancy is discussed.
authors.affiliation: Department of Animal Science, Oklahoma State University, Stillwater 74078-0353.
authors.forename: R D
authors.initials: RD
authors.lastname: Geisert
authors.forename: G L
authors.initials: GL
authors.lastname: Morgan
authors.forename: E C
authors.initials: EC
authors.lastname: Short
authors.forename: M T
authors.initials: MT
authors.lastname: Zavy
mesh_terms: D000818:Animals; D002417:Cattle; D003338:Corpus Luteum / Q000502:physiology; D015237:Dinoprost / Q000502:physiology; D005314:Embryonic and Fetal Development / Q000502:physiology*; D004702:Endocrine Glands / Q000502:physiology*; D004717:Endometrium / Q000502:physiology*; D005260:Female; D007370:Interferon Type I / Q000502:physiology; D011247:Pregnancy; D011374:Progesterone / Q000502:physiology
chemical_list: D007370:Interferon Type I; D011374:Progesterone; D015237:Dinoprost