title: On the mechanism of rat uterus desensitization to kallikrein.
abstract: An inactive form of kallikrein prepared by iodination with cold iodine, did not show any enzymatic or oxytocic action. However, a competitive pattern between this inactive and active kallikrein was observed in rat uterus preparation: When the inactive form was applied several times in the muscle, a single dose of active kallikrein was unable to cause contraction, but a double dose elicited a response. The rhythmic movement caused by a singular dose of active kallikrein, had its time curtailed by adding the inactive kallikrein to the bath. The inactive kallikrein did not interfere with bradykinin activity.
authors.affiliation: Biophysics Laboratory, Federal University of Minas Gerais, Belo Horizonte, Brazil.
authors.forename: I F
authors.initials: IF
authors.lastname: Heneine
authors.forename: M H
authors.initials: MH
authors.lastname: Feitosa
authors.forename: W T
authors.initials: WT
authors.lastname: Beraldo
authors.forename: G M
authors.initials: GM
authors.lastname: Oliveira
authors.forename: J L
authors.initials: JL
authors.lastname: Pesquero
mesh_terms: D000818:Animals; D037263:Asialoglycoprotein Receptor; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D007610:Kallikreins / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010052:Ovariectomy; D051381:Rats; D011971:Receptors, Immunologic / Q000187:drug effects / Q000502:physiology; D014590:Uterine Contraction / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects / Q000502:physiology*
chemical_list: D037263:Asialoglycoprotein Receptor; D011971:Receptors, Immunologic; D004958:Estradiol; D007610:Kallikreins