title: Three-dimensional 1H spectroscopic imaging of cerebral metabolites in the rat using surface coils.
abstract: Three dimensional metabolite maps of protonated metabolites were obtained using 1H magnetic resonance spectroscopic imaging at 7 T. Surface coils were used to increase sensitivity and spatial resolution significantly over a volume coil two-dimensional acquisition. Adiabatic pulses were employed to provide homogeneous B1 excitation and frequency selective refocusing over the volume of the rat brain. These techniques were employed to obtain three-dimensional spectroscopic imaging spectra from nominal voxel volumes of 9-30 microliters from rat brain. The improved spatial resolution and sensitivity are also demonstrated with studies of focal ischemia in the rat.
authors.affiliation: Department of Radiology, University of California, San Francisco.
authors.forename: E J
authors.initials: EJ
authors.lastname: Fernandez
authors.forename: A A
authors.initials: AA
authors.lastname: Maudsley
authors.forename: T
authors.initials: T
authors.lastname: Higuchi
authors.forename: M W
authors.initials: MW
authors.lastname: Weiner
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism*; D007091:Image Processing, Computer-Assisted; D007773:Lactates / Q000378:metabolism*; D050356:Lipid Metabolism; D009682:Magnetic Resonance Spectroscopy; D009280:Naphthaleneacetic Acids / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D007773:Lactates; D009280:Naphthaleneacetic Acids