[Hypoxemia, acid-base balance shifts and blood system reactions in adaptation mechanisms].
Experiments were carried out on nonanesthetized and anesthetized dogs with open chest. Intravenous norepinephrine infusion (0.1 microgram/kg body weight/min during 25 minutes) simulated physiological stimulation of sympathetic nervous system. In all the cases it was associated with a significant arterial oxygen tension reduction that could be considered as a reaction with an antioxidant trend. At the same time the acid--base balance parameters shift directed to metabolic acidosis was seen that correlated with the hypoxemia significance. Recorded blood picture changes--hemoglobin and hematocrit increase as well as blood sedimentation rate lowering--improved both oxygen transport and utilization.
Apollonova
L A
LA
D000136:Acid-Base Equilibrium; D000138:Acidosis / Q000503:physiopathology; D000818:Animals; D002319:Cardiovascular System / Q000503:physiopathology; D004285:Dogs; D004906:Erythrocyte Count; D005260:Female; D006400:Hematocrit; D006452:Hemoglobinometry; D006706:Homeostasis; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D010100:Oxygen / Q000097:blood; D013564:Sympathetic Nervous System / Q000503:physiopathology
D010100:Oxygen
Gipoksemiia, sdvigi kislotno-shchelochnogo balansa i reaktsii sistemy krovi v mekhanizmakh adaptatsii.