Effect of schisandrin B on lipoperoxidative damage to plasma membrane of rat liver in vitro.
The effect of schisandrin B (Sin B) on oxygen free radicals--induced lipoperoxidative damage to plasma membrane of rat hepatocytes was investigated. When the plasma membrane of rat hepatocytes was incubated with iron/cysteine or Vit C/NADPH, the production of malondialdehyde (MDA) and consumption of NADPH increased, while the membrane fluidity reduced. Addition of Sin B (3-25 micrograms.ml-1) to the incubation mixture inhibited all these alterations of the plasma membrane induced by iron/cysteine and Vit C/NADPH. The results indicated that Sin B could maintain membrane stability of rat hepatocytes under oxidative stress.
Zhang
T M
TM
Department of Pharmacology, Chinese Academy of Medical Sciences, Beijing.
Wang
B E
BE
Liu
G T
GT
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D034242:Cyclooctanes; D017705:Lignans; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008315:Malondialdehyde / Q000378:metabolism; D008560:Membrane Fluidity / Q000187:drug effects*; D009249:NADP / Q000378:metabolism; D011083:Polycyclic Compounds / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D034242:Cyclooctanes; D017705:Lignans; D011083:Polycyclic Compounds; C015499:schizandrin B; D008315:Malondialdehyde; D009249:NADP