The peripheral nerve allograft in the primate immunosuppressed with Cyclosporin A: I. Histologic and electrophysiologic assessment.
Nerve regeneration across peripheral nerve allografts and control autografts in primates immunosuppressed with Cyclosporin A was quantitatively evaluated by electrophysiologic and histologic methods. Twelve cynomolgus monkeys received 3-cm autografts and allografts in contralateral ulnar nerves. They were immunosuppressed with Cyclosporin A at 25 mg/kg per day or placebo vehicle. Morphometric analysis of nerve graft and distal nerve segments was assessed at 1 year after engraftment. Quantitative electrophysiologic studies were performed percutaneously at 6 and 12 months, and compound action potentials were measured directly across the nerve grafts at 1 year. Excellent regeneration was seen across autografts and allografts in Cyclosporin A-treated and placebo-treated recipients.
Bain
J R
JR
Department of Surgery, University of Toronto, Ont., Canada.
Mackinnon
S E
SE
Hudson
A R
AR
Wade
J
J
Evans
P
P
Makino
A
A
Hunter
D
D
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D016572:Cyclosporine / Q000008:administration & dosage / Q000627:therapeutic use*; D004576:Electromyography; D006084:Graft Rejection; D015395:Histocompatibility Antigens Class I / Q000032:analysis; D016867:Immunocompromised Host; D008214:Lymphocytes / Q000276:immunology; D008252:Macaca fascicularis; D008297:Male; D009046:Motor Neurons / Q000473:pathology / Q000502:physiology; D009412:Nerve Fibers / Q000473:pathology / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology; D009431:Neural Conduction / Q000502:physiology; D010919:Placebos; D011446:Prospective Studies; D011897:Random Allocation; D013497:Sural Nerve / Q000473:pathology / Q000503:physiopathology / Q000637:transplantation*; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D014459:Ulnar Nerve / Q000473:pathology / Q000503:physiopathology / Q000601:surgery
D015395:Histocompatibility Antigens Class I; D010919:Placebos; D016572:Cyclosporine