Pulmonary hemorrhage and glomerulonephritis in primary biliary cirrhosis.
We observed life-threatening intrapulmonary hemorrhages and focal proliferative glomerulonephritis in a 41-yr-old woman with primary biliary cirrhosis. The severity of the symptoms necessitated blood transfusions and mechanical ventilation; the patient improved with the help of corticosteroid therapy. No formal evidence of either Goodpasture's syndrome or any other well-defined systemic vasculitis could be found. Neutrophil cytoplasmic antibodies were initially positive and became undetectable after 3 mo of immunosuppressive treatment without relapse. This association has not been described previously and may be added to the list of extrahepatic immune-mediated conditions associated with primary biliary cirrhosis.
Bissuel
F
F
Services d'Hépato-gastroentérologie, Hôpital de l'Hôtel-Dieu, Lyon, France.
Bizollon
T
T
Dijoud
F
F
Bouletreau
P
P
Cordier
J F
JF
Chazot
C
C
Gouillat
C
C
Trepo
C
C
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001803:Blood Transfusion; D005260:Female; D005921:Glomerulonephritis / Q000150:complications* / Q000473:pathology / Q000628:therapy; D006470:Hemorrhage / Q000150:complications* / Q000628:therapy; D006801:Humans; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000473:pathology / Q000628:therapy; D008171:Lung Diseases / Q000150:complications* / Q000628:therapy; D008775:Methylprednisolone / Q000627:therapeutic use; D013577:Syndrome
D000900:Anti-Bacterial Agents; D008775:Methylprednisolone