Analysis of factors in hypertension: change of membrane fluidity in the arteries of spontaneously hypertensive and monocrotaline-injected rats.
1. A change of membrane fluidity of a small piece of artery tissue was monitored by Fourier transform infra-red spectroscopy. 2. The measurement of carotid artery in situ revealed that a significant change in the peak position of the methylene absorbance was detected in the spontaneously hypertensive rat subjected to anoxia, but not in the Wistar-Kyoto rat carotid. The shift of a peak to the higher wavenumber position suggested that the averaged membrane fluidity of the artery was increased by the anoxic treatment. A similar change of membrane fluidity was also observed in a pulmonary hypertension induced by monocrotaline. 3. At 4 weeks after the injection of monocrotaline, the membrane fluidity was increased in the pulmonary artery tissue. 4. The change of membrane fluidity may be caused by the change of activity of phospholipases in the arteries with hypertension.
Takeshita
M
M
Department of Biochemistry Medical College of Oita, Japan.
Yoshida
S
S
Miyata
M
M
Yoshida
H
H
D000818:Animals; D001158:Arteries / Q000503:physiopathology*; D006973:Hypertension / Q000139:chemically induced / Q000235:genetics / Q000503:physiopathology*; D006976:Hypertension, Pulmonary / Q000139:chemically induced / Q000503:physiopathology; D002534:Hypoxia, Brain / Q000503:physiopathology; D008560:Membrane Fluidity / Q000502:physiology*; D016686:Monocrotaline; D010740:Phospholipases / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013055:Spectrophotometry, Infrared
D016686:Monocrotaline; D010740:Phospholipases