Serum interleukin-2 receptor and interferon-alpha levels in a patient with allergic granulomatous angiitis (Churg-Strauss).
A patient with allergic granulomatous angiitis accompanied by increases in serum interleukin-2 receptor (IL-2R) and interferon-alpha (IFN-alpha) levels is reported. Laboratory findings revealed leukocytosis with eosinophilia and increased serum IgE and IgG. The serum IL-2R and IFN-alpha were increased. The serum immune complex, interferon-beta, -gamma and complements remained at normal levels. The serum IgE, IgG, IL-2R and IFN-alpha correlated with disease activity. Immunofluorescent studies using frozen sections obtained from the dermal lesion showed no immunoglobulin or complement deposits on vascular walls. Measurements of serum IL-2R and IFN-alpha might be considered reliable serologic indicators of disease activity.
Hayasaka
T
T
Department of Internal Medicine, Hakodate Chuo Hospital, Japan.
Sasaki
H
H
Sugawara
T
T
Yasuura
S
S
Kawamura
T
T
D000328:Adult; D015267:Churg-Strauss Syndrome / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D016898:Interferon-alpha / Q000097:blood*; D011239:Prednisolone / Q000627:therapeutic use; D015375:Receptors, Interleukin-2 / Q000032:analysis*
D007136:Immunoglobulins; D016898:Interferon-alpha; D015375:Receptors, Interleukin-2; D003165:Complement System Proteins; D011239:Prednisolone