title: [Recurrences after completion of the treatment of acute lymphoblastic leukemia in children].
abstract: Within the past 16 years, 2004 children with the acute lymphoblastic leukemia were treated at the Centres of the Polish Pediatric Study Group. The treatment was completed in 887 patients (44.3%) with the first remission. Recurrence was noted in 180 children (20.3%). This group was analysed in view of the type of therapy and its effect on the survival rate, significance of recurrence following therapy, character and localization of recurrent disease, and further fate of patients. It was found, that patients with isolated late nuclear recurrence have greatest chances to achieve subsequent remission. Most frequent and severe is recurrent bone marrow involvement which requires intensive chemotherapy combined with bone marrow transplantation due to unfavourable prognosis. Patients with the first recurrence of the acute lymphoblastic leukemia have a chance to achieve subsequent remission and long-term survival.
authors.affiliation: Katedry i Kliniki Hematologii i Chorób Rozrostowych AM, Warszawie.
authors.forename: M
authors.initials: M
authors.lastname: Ochocka
authors.forename: M
authors.initials: M
authors.lastname: Matysiak
authors.forename: T
authors.initials: T
authors.lastname: Newecka-Samól
authors.forename: M
authors.initials: M
authors.lastname: Kulus
authors.forename: J
authors.initials: J
authors.lastname: Armata
authors.forename: W
authors.initials: W
authors.lastname: Balwierz
authors.forename: J
authors.initials: J
authors.lastname: Bogusławska-Jaworska
authors.forename: A
authors.initials: A
authors.lastname: Chybicka
authors.forename: T
authors.initials: T
authors.lastname: Jackowska
authors.forename: M
authors.initials: M
authors.lastname: Jakowicka
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001215:Asparaginase / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000209:etiology / Q000401:mortality; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D011241:Prednisone / Q000008:administration & dosage; D011379:Prognosis; D012074:Remission Induction; D013997:Time Factors; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D003520:Cyclophosphamide; D001215:Asparaginase; D011241:Prednisone; D008727:Methotrexate; D003630:Daunorubicin
vernacular_title: Wznowy po zakończeniu leczenia ostrej białaczki limfoblastycznej u dzieci.