[Comparative activities of ciprofloxacin, amoxicillin, and cotrimoxazole in an experimental model of enteritis caused by Salmonella non typhi].
With the use of an in vitro experimental model of enteritis by Salmonella non typhi the efficacy of amoxicillin, cotrimoxazole and ciprofloxacin in the eradication of this fecal pathogen and the prevention of bacteremia was evaluated. Following a fasting period of 48 hours a total of 160 rats were administered 10 UFC of 2 strains of Salmonella non typhi via intragastric tubing. One of the strains was sensitive to amoxycillin and cotrimoxazole (60 rats) and the other strain was resistant to both but was sensitive to ciprofloxacin (100 rats). The antimicrobials were administered 24 hours after the bacterial infection in daily doses for 5 consecutive days. According to the results obtained amoxicillin and cotrimoxazole were ineffective in the eradication of the fecal pathogen indicating an important obstacle in the appearance of bacteremias. To the contrary, ciprofloxacin, even at low doses, eliminated the microorganisms early and demonstrated high efficacy in the prevention of bacteremia in the animals when these results were compared with those of the untreated group.
Gómez-Garcés
J L
JL
Servicio de Microbiología Clínica, Fundación Jiménez Díaz, Madrid.
Castilla
C
C
D000658:Amoxicillin / Q000627:therapeutic use*; D000818:Animals; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004751:Enteritis / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D051381:Rats; D017208:Rats, Wistar; D012481:Salmonella Infections, Animal / Q000188:drug therapy*; D012477:Salmonella enteritidis; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use*
D002939:Ciprofloxacin; D000658:Amoxicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
Actividad comparada de ciprofloxacino, amoxicilina y cotrimoxazol en un modelo experimental de enteritis por Salmonella no typhi.