Cytogenetic analysis of spontaneous abortions with direct analysis of chorionic villi.
A total of 224 cases of spontaneous abortions were studied by analysing chromosomes directly from chorionic villi. Abnormal karyotypes were found in 51.3% of the investigated cases. Among the chromosome abnormalities the most frequent were the trisomies (55.7%), followed by polyploidy (23.5%), monosomy X (15.6%) and structural anomalies (5.2%). The rapid and relatively simple method is suitable for studying the causes of spontaneous abortions, and this information may be helpful also for genetic counselling.
Gardó
S
S
Department of Obstetrics and Gynecology, County Hospital, Györ, Hungary.
Bajnóczky
K
K
D000022:Abortion, Spontaneous / Q000235:genetics*; D002824:Chorionic Villi / Q000648:ultrastructure*; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008423:Maternal Age; D009006:Monosomy; D011123:Polyploidy; D011247:Pregnancy; D014314:Trisomy