Distribution of tissue markers in acinic cell carcinomas of salivary gland.
Eight cases of acinic cell carcinoma of the salivary glands were histologically reclassified and their immunohistochemical expression and distribution for various tissue antigens were examined. The epithelial elements were divided into tubuloglandular components, microcystic patterns and solid nests. The authors' results indicated the following: 1) The duct luminal cells of tubuloglandular components have distinct epithelial features with cytokeratin (KL 1), alpha 1-antichymotrypsin (alpha 1-ACT), transferrin, lactoferrin, IgA, and carcinoembryonic antigen (CEA) positivity. 2) The cyst-lining cells of microcystic pattern expressed immunophenotypes similar to those of the duct luminal cells. 3) The acinic cells in solid nests had positive results for KL 1, alpha 1-antitrypsin (alpha 1-AT), transferrin, lactoferrin and vasoactive intestinal polypeptide (VIP). 4) The clear cells in solid areas had positive results for KL 1, alpha 1-AT, transferrin and VIP. Both the clear cells and the neoplastic acinic cells showed a rather similar pattern of immunoreactivity. Therefore, the clear cells may transform from the neoplastic acinic cells. 5) Secretory products in tubuloglandular and microcystic patterns had positive results for alpha 1-ACT, lactoferrin, IgA and CEA. 6) The basement membrane-like material between the neoplastic islands has distinct positivity for alpha 1-AT. The result suggests that alpha 1-AT is a useful marker of basement membrane-like material.
Takahashi
H
H
Department of Oral Pathology, Nagasaki University School of Dentistry, Japan.
Fujita
S
S
Okabe
H
H
Tsuda
N
N
Tezuka
F
F
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000737:chemistry*; D002277:Carcinoma / Q000737:chemistry* / Q000473:pathology; D003593:Cytoplasm / Q000737:chemistry; D005260:Female; D005293:Ferritins / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D007382:Intermediate Filaments / Q000737:chemistry; D007781:Lactoferrin / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011506:Proteins / Q000032:analysis; D012016:Reference Values; D012468:Salivary Gland Neoplasms / Q000737:chemistry* / Q000473:pathology; D014168:Transferrin / Q000032:analysis; D000514:alpha 1-Antichymotrypsin / Q000032:analysis*; D000515:alpha 1-Antitrypsin / Q000032:analysis*
D014408:Biomarkers, Tumor; D011506:Proteins; D014168:Transferrin; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin; D005293:Ferritins; D007781:Lactoferrin