title: The effects of adrenaline, hyaluronidase and age on peribulbar anaesthesia.
abstract: In a prospective, randomised, masked trial, 91 patients undergoing intraocular surgery received an anaesthetic mixture containing lignocaine hydrochloride 2% and bupivacaine hydrochloride 0.5%. In addition group 1 had hyaluronidase (50 i.u./ml) and adrenaline (1:200,000), group 2 had hyaluronidase alone, group 3 had adrenaline alone and group 4 had neither. The groups were compared regarding the quality of operating conditions. Hyaluronidase had a substantial beneficial effect though there was no significant difference related to the use of adrenaline. Anaesthesia was less effective in patients under the age of 65 years.
authors.affiliation: University Hospital of Wales, Heath Park, Cardiff.
authors.forename: C D
authors.initials: CD
authors.lastname: Morsman
authors.forename: R
authors.initials: R
authors.lastname: Holden
mesh_terms: D000367:Age Factors; D000368:Aged; D000765:Anesthesia, Conduction / Q000379:methods*; D002045:Bupivacaine; D002387:Cataract Extraction; D004837:Epinephrine; D005260:Female; D006801:Humans; D006821:Hyaluronoglucosaminidase; D008012:Lidocaine; D008297:Male; D013508:Ophthalmologic Surgical Procedures; D011446:Prospective Studies
chemical_list: D008012:Lidocaine; D006821:Hyaluronoglucosaminidase; D002045:Bupivacaine; D004837:Epinephrine