Kinin antagonist blunts the diuretic effect of furosemide in deoxycorticosterone-treated rats.
Furosemide at a dose of 3 mg/kg body wt increased urinary volume (vehicle: 12.8 +/- 0.6; furosemide: 42.4 +/- 2.6 ml/8h, p < 0.01) and urinary sodium excretion (vehicle: 0.9 +/- 0.1; furosemide: 5.0 +/- 0.4 mM/8h, p < 0.01) in deoxycorticosterone-treated rats. These effects were associated to a decrease in mean blood pressure (from 122 +/- 4 to 113 +/- 3 mmHg, p < 0.01) and renal vascular resistances (from 15.6 +/- 0.6 to 14.3 +/- 0.7 RU, p < 0.05). The B2-receptor antagonist D-Arg[Hyp3,Thi5,D-Tic7,Oic8]-bradykinin significantly blunted the diuretic and natriuretic effect of furosemide and completely prevented the decrease in blood pressure and renal vascular resistances. The renal kallikrein-kinin system may modulate the diuretic and hemodynamic effects of furosemide in conditions of increased mineralcorticoid activity.
Madeddu
P
P
Clinica Medica and Farmacologia, Sassari University, Italy.
Glorioso
N
N
Pinna Parpaglia
P
P
Demontis
M P
MP
Varoni
M V
MV
Fattaccio
M C
MC
Sabino
G
G
Pisanu
G
G
Patteri
G
G
Anania
V
V
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001920:Bradykinin / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D003900:Desoxycorticosterone / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects*; D005665:Furosemide / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007668:Kidney / Q000098:blood supply / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D014655:Vascular Resistance / Q000187:drug effects
D003900:Desoxycorticosterone; D005665:Furosemide; C065679:icatibant; D001920:Bradykinin