The effect of hyaluronan on interleukin-1 alpha-induced prostaglandin E2 production in human osteoarthritic synovial cells.
An in vitro study on the effects of hyaluronan (HA) on interleukin-1 alpha-induced prostaglandin E2 (PGE2) production in human osteoarthritic synovial cells indicated that PGE2 induction was suppressed by HA in a dose- and molecular weight-dependent manner.
Yasui
T
T
Division of Biochemical Pharmacology, Maruho Co., Ltd, Osaka, Japan.
Akatsuka
M
M
Tobetto
K
K
Hayaishi
M
M
Ando
T
T
D002478:Cells, Cultured; D015232:Dinoprostone / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006820:Hyaluronic Acid / Q000494:pharmacology*; D007375:Interleukin-1 / Q000494:pharmacology*; D008970:Molecular Weight; D010003:Osteoarthritis / Q000378:metabolism*; D013583:Synovial Membrane / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
D007375:Interleukin-1; D006820:Hyaluronic Acid; D015232:Dinoprostone