title: Modified anastomotic technique for 1 millimeter internal diameter polytetrafluoroethylene arterial grafts in the rat.
abstract: Reported patency rates after standard end-to-end anastomoses for microvascular prosthetic grafts have been inconsistent and usually disappointing. A modified anastomotic technique is described in which the prosthetic graft is invaginated inside the arterial lumen. In this study of 6 cm lengths of 1 mm internal diameter polytetrafluoroethylene femoro-femoral bypass grafts in the rat, 6 (40%) of 15 grafts with standard anastomoses were patent at 6 months compared to 28 (90%) of 31 grafts using the modified anastomotic technique (P < 0.001). With invagination of the prosthetic graft inside the arterial lumen, reliable high patency rates can be achieved with microvascular prostheses long enough for potential clinical applications.
authors.affiliation: Department of Surgery, University of Sydney, NSW, Australia.
authors.forename: M J
authors.initials: MJ
authors.lastname: Golding
authors.forename: J P
authors.initials: JP
authors.lastname: Harris
authors.forename: J
authors.initials: J
authors.lastname: May
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods*; D000818:Animals; D001807:Blood Vessel Prosthesis; D004547:Elastic Tissue / Q000473:pathology; D004730:Endothelium, Vascular / Q000473:pathology; D005263:Femoral Artery / Q000473:pathology / Q000601:surgery*; D006083:Graft Occlusion, Vascular / Q000473:pathology; D008297:Male; D008866:Microsurgery; D011138:Polytetrafluoroethylene / Q000737:chemistry; D011474:Prosthesis Design; D051381:Rats; D017208:Rats, Wistar; D013499:Surface Properties; D013536:Suture Techniques; D013927:Thrombosis / Q000473:pathology; D014654:Vascular Patency
chemical_list: D011138:Polytetrafluoroethylene