[The prevention of the translocation of intestinal microflora after the rescue of an organism from a terminal state].
In experiments on guinea pigs, the animals were resuscitated from clinical death caused by the acute loss of blood and subsequently treated intragastrically with enterosorbents: activated carbon fibrous material, alone and in combination with polymyxin B, polyphepan (a lignin derivative), polymethyloxan hydrogel and the sorbent Enterocat. In the animals, not treated during the postresuscitation period, a high population level of enterobacteria and Gram-positive aerobic cocci was registered in the contents of the small and large intestines and their translocation to mesenteric lymph nodes, liver, spleen and blood was observed. The amount of lactobacilli in the small intestine was decreased. Enterosorbents were found to decrease a high population level of intestinal microflora, to prevent the translocation of Gram-positive aerobic cocci and to inhibit the penetration of enterobacteria through the enteric barrier in the postresuscitation period. Combined use of activated carbon fibrous material with polymyxin B proved to be most effective for the elimination of enterobacteria.
Almagambetov
K Kh
KKh
Bondarenko
V M
VM
Gorskaia
E M
EM
Pavlova
L A
LA
Sudzhan
E V
EV
Grigor'ev
A V
AV
D000208:Acute Disease; D000818:Animals; D001424:Bacterial Infections / Q000382:microbiology / Q000517:prevention & control*; D002606:Charcoal / Q000627:therapeutic use; D016061:Enterosorption / Q000379:methods; D005260:Female; D006470:Hemorrhage / Q000150:complications / Q000382:microbiology / Q000628:therapy; D007422:Intestines / Q000382:microbiology*; D008297:Male; D011112:Polymyxin B / Q000627:therapeutic use; D051381:Rats; D012151:Resuscitation / Q000379:methods*
D002606:Charcoal; D011112:Polymyxin B
Profilaktika translokatsii kishechnoĭ mikroflory posle vyvedeniia organizma iz terminal'nogo sostoianiia.