Massive perinatal hepatic necrosis from maternal oxytocin overdose.
Review of clinical records regarding administration of oxytocin may provide clues to the etiology of hepatic infarction in the neonate. The authors present a case in which a large and rapid maternal overdose of oxytocin (17,300 mU over 20 min) during end-stage labor was associated with neonatal death and extensive hepatic infarction. These findings represent novel complications of oxytocin administration.
Robichaux
W H
WH
Department of Pathology, Children's Hospital of Pittsburgh, Pennsylvania.
Perper
J A
JA
Knisely
A S
AS
D000328:Adult; D062787:Drug Overdose; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007238:Infarction / Q000139:chemically induced; D007743:Labor, Obstetric; D007969:Leukomalacia, Periventricular / Q000139:chemically induced; D008099:Liver / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D008431:Maternal-Fetal Exchange; D009336:Necrosis; D010121:Oxytocin / Q000008:administration & dosage / Q000009:adverse effects*; D011247:Pregnancy
D010121:Oxytocin