Effect of non-steroidal anti-inflammatory drugs on glutathione levels in various organs of rat.
Since glutathione (GSH) depletion (about 20% of total GSH content) can impair the cell's defence against the toxic actions of drugs and may lead to cell injury and death, we examined the effect of piroxicam, naproxen and ketoprofen on GSH levels in various organs of the rat (brain, eye, liver, stomach, heart, leg adductor muscle). Ketoprofen in brain and leg adductor muscle dramatically decreases the GSH levels, giving rise to potential cellular toxicity.
Micheli
L
L
Istituto di Farmacologia, Università degli Studi, Siena, Italy.
Fiaschi
A I
AI
Giorgi
G
G
Cerretani
D
D
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D016923:Cell Death / Q000187:drug effects; D005123:Eye / Q000187:drug effects / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D006321:Heart / Q000187:drug effects; D007660:Ketoprofen / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism; D009288:Naproxen / Q000494:pharmacology; D010894:Piroxicam / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; D009288:Naproxen; D007660:Ketoprofen; D005978:Glutathione