Microbial transformation of benzocyclobutene to benzocyclobutene-1-ol and benzocyclobutene-1-one.
Oxidation of benzocyclobutene by intact cells of Pseudomonas fluorescens 127-68 XVII, containing naphthalene dioxygenase, yielded exclusively benzylic oxidation products; benzocyclobutene-1-ol and benzocyclobutene-1-one. No evidence for incorporation of oxygen into the aromatic ring was found.
Swanson
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PE
Biocatalysis Group-Organic Chemicals & Polymers Laboratory, Dow Chemical Company, Midland, Michigan 48674.
D001711:Biotransformation; D003503:Cyclobutanes / Q000737:chemistry / Q000493:pharmacokinetics*; D049308:Dioxygenases; D009097:Multienzyme Complexes / Q000378:metabolism*; D010105:Oxygenases / Q000378:metabolism*; D011551:Pseudomonas fluorescens / Q000378:metabolism*
D003503:Cyclobutanes; D009097:Multienzyme Complexes; D010105:Oxygenases; D049308:Dioxygenases; C038703:naphthalene dioxygenase