[The gametotoxic effect of antenatal exposure to thiotepa in mice].
ThioTEPA was injected intraperitoneally into female 101/H and CBA mice on day 12 of pregnancy at a dose of 2.5 mg/kg body weight. As a result, the number of prospermatogonia in 19-day-old male fetuses decreased to 78.8% in 101/H mice and to 63.7% in CBA mice. The gametotoxic effect on the male offspring (F1) in 101/H mice treated with thioTEPH included the significant decrease in the number of spermatogonia A, spermatocytes I at preleptotene and pachytene, as well as of spermatids at the stage 7 of development. Interstrain differences are described in the intensity of spermatogenesis in the mature intact animals and in regeneration capacity of gonads after prenatal thioTEPA administration.
Khil'kevich
L V
LV
Kurilo
L F
LF
D000818:Animals; D005260:Female; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013045:Species Specificity; D013087:Spermatids / Q000187:drug effects; D013090:Spermatocytes / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*; D013093:Spermatogonia / Q000187:drug effects; D013737:Testis / Q000187:drug effects / Q000196:embryology / Q000254:growth & development; D013852:Thiotepa / Q000633:toxicity*
D013852:Thiotepa
Gametotoksicheskiĭ éffekt antenatal'nogo vozdeĭstviia tiotéf u mysheĭ.