Platelet signal transduction mechanisms induced by eicosanoids.
Platelets are in many ways involved in the pathogenesis of artherosclerosis and the development of coronary heart disease, and play a role in acute myocardial infarction (8). They are also an useful model to study cellular activation mechanisms: their isolation from peripheral venous blood is simple and rapid and their physiological responses such as shape change, aggregation and secretion can be easily measured (10). This chapter is focused on our results on the mechanisms of platelet activation and inhibition induced by eicosanoids.
Siess
W
W
Institut für Prophylaxe und Epidemiologie, Kreislaufkrankheiten b.d. Universität München, FRG.
Grünberg
B
B
Luber
K
K
Vauti
F
F
Wilhelm
B
B
D001792:Blood Platelets / Q000378:metabolism*; D015777:Eicosanoids / Q000494:pharmacology*; D006801:Humans; D015539:Platelet Activation / Q000187:drug effects; D011453:Prostaglandins / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects*; D013931:Thromboxanes / Q000494:pharmacology; D010738:Type C Phospholipases / Q000378:metabolism
D015777:Eicosanoids; D011453:Prostaglandins; D013931:Thromboxanes; D010738:Type C Phospholipases