Dose dependent induction of the microsomal monooxygenase aryl hydrocarbon hydroxylase in isolated peripheral blood monocytes: the influence of age.
The induction of the microsomal monooxygenase benzo(alpha)pyrene hydroxylase was investigated in isolated peripheral blood monocytes from young and old donors, after exposure to different concentrations of benzanthracene as an inducing agent. The sensitivity of the cells to the inducing stimulus was not dependent on the age of the donor. The mechanisms underlying impaired monooxygenase induction in the elderly remain to be clarified.
George
G
G
University Department of Geriatric Medicine, Cardiff Royal Infirmary, Wales, U.K.
Woodhouse
K
K
D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood*; D001551:Benz(a)Anthracenes / Q000494:pharmacology*; D001579:Benzopyrene Hydroxylase / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction; D005260:Female; D006801:Humans; D008297:Male; D009000:Monocytes / Q000187:drug effects / Q000201:enzymology*
D001551:Benz(a)Anthracenes; C030935:benz(a)anthracene; D001579:Benzopyrene Hydroxylase