Effect of oxiracetam on scopolamine-induced amnesia in the rat in a spatial learning task.
The effects of the nootropic agent 4-hydroxy-2-oxopyrrolidinoacetamide (oxiracetam) on memory and performance impairments induced by scopolamine were evaluated in the Morris water maze task. No effect was seen on the performance of rats when treated with oxiracetam (30 mg/kg, IP) alone. Task performance of scopolamine (0.2 mg/kg, SC)-treated rats was impaired as compared to that of control animals. The behavioral deficits expressed in the task by scopolamine treatment were attenuated by the same dose of oxiracetam.
Pitsikas
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N
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Algeri
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S
D000818:Animals; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D011619:Psychotropic Drugs / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D012601:Scopolamine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D013028:Space Perception / Q000187:drug effects*
D011619:Psychotropic Drugs; D011759:Pyrrolidines; D012601:Scopolamine; C040619:oxiracetam