Hypothyroid induced hypometabolic state as a possible diagnostic and therapeutic maneuver.
Diseased cells possibly function autonomously without as much dependence upon metabolic cues such as thyroid hormone by comparison to normal cells. Therefore if reversible hypothyroidism can be induced briefly in euthyroid patients, conceivably normal cells can be induced into a hypometabolic state while the diseased cells continue at their baseline or near baseline metabolic level. This induced difference could be utilized to isolate and target abnormal cells better.
Carlin
K
K
Endocrinology Dept., Brooke Army Medical Center, San Antonio, Texas 78234.
Carlin
S
S
D001481:Basal Metabolism; D015658:HIV Infections / Q000628:therapy; D006801:Humans; D007037:Hypothyroidism / Q000209:etiology / Q000378:metabolism*; D013963:Thyroid Hormones / Q000502:physiology*
D013963:Thyroid Hormones