title: Simultaneous MR acquisition of arterial and brain signal-time curves.
abstract: Regional cerebral blood flow (rCBF) provides important information about local neuronal functional and cerebrovascular status. Determination of rCBF requires sequential measurements of tracer concentration in arterial blood and brain tissue unless the tracer is trapped in the brain in proportion to rCBF. Since gadopentate dimeglumine is not trapped within brain tissue, we have developed the simultaneous dual FLASH pulse sequence (SDFLASH) which sequentially measures the MR signal change in both the internal carotid artery and brain parenchyma simultaneously during the passage of a bolus of paramagnetic contrast material.
authors.affiliation: Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110.
authors.forename: W H
authors.initials: WH
authors.lastname: Perman
authors.forename: M H
authors.initials: MH
authors.lastname: Gado
authors.forename: K B
authors.initials: KB
authors.lastname: Larson
authors.forename: J S
authors.initials: JS
authors.lastname: Perlmutter
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology* / Q000098:blood supply; D002343:Carotid Artery, Internal / Q000033:anatomy & histology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D003287:Contrast Media; D004285:Dogs; D005682:Gadolinium; D019786:Gadolinium DTPA; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009942:Organometallic Compounds; D004369:Pentetic Acid
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA