title: Effects of cocaine and ethylcocaine on schedule-controlled responding in rats.
abstract: The effects of cocaine and benzoylecognine ethyl ester (ethylcocaine), its metabolite found only in simultaneous users of cocaine and ethanol, were studied in rats responding for food under a multiple fixed-ratio fixed-interval schedule of food presentation. Both cocaine and ethylcocaine increased rates of responding under the fixed-interval component and decreased the quarter life. Both drugs only decreased rates of responding under the fixed-ratio component. Cocaine was approximately equipotent to ethylcocaine. Ethylcocaine may contribute to interactions between cocaine and ethanol by exerting cocaine-like effects not seen with other cocaine metabolites.
authors.affiliation: Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock 72205.
authors.forename: S
authors.initials: S
authors.lastname: Shelnutt
authors.forename: T J
authors.initials: TJ
authors.lastname: Hudzik
authors.forename: D L
authors.initials: DL
authors.lastname: Lattin
authors.forename: D E
authors.initials: DE
authors.lastname: McMillan
mesh_terms: D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D003042:Cocaine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012055:Reinforcement Schedule
chemical_list: D000779:Anesthetics, Local; C066444:cocaethylene; D003042:Cocaine