title: Elevation of C-reactive protein in serum of Channa punctatus as an indicator of water pollution.
abstract: Effect of some pollutants like heavy metals, non-metals and pesticides on the circulating level of C-reactive protein (CRP) which is an acute phase plasma protein was studied in a freshwater murrel C. punctatus. Fish was exposed to nonlethal doses of these xenobiotics which were apparently safe. But the level of CRP detected by sensitive single radial immunodiffusion (SRID) technique showed that within 12 hr of exposure the nonlethal doses of xenobiotics could initiate the acute phase response in terms of elevated CRP titre. Heavy metals caused the acute phase within 24 hr, nonmetals and Metacid-50 within 48 hr exposure. The carbamate compound, carbaryl demonstrated a biphasic response to CRP level which may be correlated with the reversible type of anticholinesterase property of this compound while Metacid-50 is an irreversible type of anticholinesterase agent. The assessment of the CRP level in the serum of fish may be utilized as a primary bioindicator of a contaminated environment toxic enough to mount an acute phase response.
authors.affiliation: Department of Zoology, Visva-Bharati University, Santiniketan, India.
authors.forename: S
authors.initials: S
authors.lastname: Ghosh
authors.forename: S
authors.initials: S
authors.lastname: Bhattacharya
mesh_terms: D000641:Ammonia / Q000494:pharmacology; D000818:Animals; D002097:C-Reactive Protein / Q000096:biosynthesis*; D002104:Cadmium / Q000494:pharmacology; D019256:Cadmium Chloride; D012721:Carbaryl / Q000494:pharmacology; D002712:Chlorides / Q000494:pharmacology; D005399:Fishes / Q000097:blood*; D008627:Mercuric Chloride / Q000494:pharmacology; D008743:Methyl Parathion / Q000494:pharmacology; D010636:Phenols / Q000494:pharmacology; D014877:Water Pollution, Chemical
chemical_list: D002712:Chlorides; D010636:Phenols; D002104:Cadmium; D008743:Methyl Parathion; D008627:Mercuric Chloride; D000641:Ammonia; D002097:C-Reactive Protein; D019256:Cadmium Chloride; D012721:Carbaryl