title: Behavioural changes in children following minor surgery--is premedication beneficial?
abstract: One hundred and twenty-three male children, aged one to ten years, were studied to determine the influence of premedication on changes in patterns of behaviour following hospitalization for repair of inguinal hernias. Four comparable groups were selected for premedication regimen: (1) A control group without premedication; (2) oral trimeprazine tartrate 2 mg/kg, methadone 0.1 mg/kg and droperidol 0.15 mg/kg; (3) oral midazolam 0.45 mg/kg; (4) intramuscular midazolam 0.15 mg/kg. Standard inhalational anesthesia was used and caudal blocks employed for analgesia. The parents returned a questionnaire at two weeks. Changes in behaviour were reported in 78% of the children and overall, premedication showed little benefit. However, midazolam premedication was associated with a significantly lower incidence of night-time crying and awakening, compared with no premedication. Only for night-time crying and day-time toilet training did age below five years prove to be a significant contributing factor.
authors.affiliation: Department of Anesthesiology, Medical School, University of Stellenbosch, Tygerberg, South Africa.
authors.forename: K A
authors.initials: KA
authors.lastname: Payne
authors.forename: A R
authors.initials: AR
authors.lastname: Coetzee
authors.forename: F J
authors.initials: FJ
authors.lastname: Mattheyse
authors.forename: J J
authors.initials: JJ
authors.lastname: Heydenrych
mesh_terms: D001010:Anxiety, Separation; D002648:Child; D002652:Child Behavior; D002675:Child, Preschool; D004775:Enuresis / Q000523:psychology; D005247:Feeding Behavior; D006552:Hernia, Inguinal / Q000601:surgery*; D006801:Humans; D007223:Infant; D008297:Male; D008691:Methadone / Q000008:administration & dosage; D008874:Midazolam / Q000008:administration & dosage; D011229:Preanesthetic Medication; D013514:Surgical Procedures, Operative / Q000523:psychology*; D014039:Toilet Training; D014291:Trimeprazine / Q000008:administration & dosage / Q000031:analogs & derivatives
chemical_list: C031242:trimeprazine tartrate; D014291:Trimeprazine; D008874:Midazolam; D008691:Methadone