Na(+)-dependent AIB transport by neuroblastoma cells.
Na(+)-dependent amino isobutyric acid transport by two neuroblastoma cell lines with and without amplification of the oncogene N-myc is studied. Surprisingly, the contribution of system A is greater in the cell line showing no N-myc amplification. Preliminary data support a role for essential tyrosine and cysteine residues in the active center of the carriers, mainly in system A.
del Castillo-Olivares
A
A
Ruprecht-Karls-Universität, Heidelberg, Germany.
Medina
M A
MA
D000596:Amino Acids / Q000494:pharmacology; D000621:Aminoisobutyric Acids / Q000378:metabolism*; D001692:Biological Transport / Q000187:drug effects; D005784:Gene Amplification; D016259:Genes, myc; D009447:Neuroblastoma / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D000596:Amino Acids; D000621:Aminoisobutyric Acids; D012964:Sodium