DNA-coated carbon adsorbents experimental assessment and results of severe psoriasis treatment.
Newly developed combined adsorbents, containing from 1 to 8 mg of thymic DNA per 1 g of the granulated or the fibrous carbonic matrix, demonstrated good biocompatibility and selectivity for DNA- and DNP-binding substances. In a group of 14 patients with severe psoriasis (uncontrol trial) a single hemoperfusion procedure through DNA-coated granulated synthetic carbons (perfusion volume was 2.5-3.1 L, sorbent quantity was 30 g) resulted in complete remission in 6 patients and in substantial improvement of clinical status in 6 other patients. A positive effect was observed in 4 patients during 7-11 months; in 8 patients it is being observed for more than 29-33 months. The double-blind tests in the group of patients subjected to hemoperfusion through the DNA-coated charcoal (27 people) and uncoated charcoal (9 people) showed the full-scale remission in 55.5% and 11.2% respectively. The authors believe that the DNA-coated activated carbons can be an effective therapeutic procedure for treatment of numerous immuno-dependent diseases and states associated with disorders in the kinetics of cell division.
Snezhkova
E A
EA
Kavetsky Institute for Oncology and Radiobiology, Problems AS Ukr.SSR Kiev, USSR.
Kolyadenko
V G
VG
Nikolaev
V G
VG
Korol
V N
VN
Nikitin
A A
AA
Behm
E
E
Ponomarev
V L
VL
Alexeenko
L P
LP
Amalyan
V A
VA
D000974:Antibodies, Antinuclear / Q000378:metabolism; D001665:Binding Sites; D001672:Biocompatible Materials; D002244:Carbon / Q000008:administration & dosage*; D004247:DNA / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D008297:Male; D011565:Psoriasis / Q000188:drug therapy*
D000974:Antibodies, Antinuclear; D001672:Biocompatible Materials; D002244:Carbon; D004247:DNA