Translocation (12;17)(p11-12;q11-12): a recurrent primary rearrangement in acute leukemia.
We identified two patients with acute leukemia in relapse (one lymphoblastic and the other with evidence of mixed lymphoid-myeloid differentiation) with t(12;17)(p12;q11) as the primary karyotypic abnormality. There are six previously reported cases of acute leukemia with an identical or similar translocation. To our knowledge, t(12;17) has not been reported in other forms of neoplasia. A review of these cases suggests that t(12;17) carries a poor prognosis.
Liu
H W
HW
Department of Pathology, Queen Mary Hospital, University of Hong Kong.
Wan
S K
SK
Ching
L M
LM
Liang
R
R
Chan
L C
LC
D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D002881:Chromosomes, Human, Pair 12; D002886:Chromosomes, Human, Pair 17; D015321:Gene Rearrangement; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000235:genetics* / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D011379:Prognosis; D014178:Translocation, Genetic
D015703:Antigens, CD; D000951:Antigens, Neoplasm