title: Cryptococcus neoformans varieties as agents of cryptococcosis in Brazil.
abstract: The study of the clinical isolates of Cryptococcus neoformans from 83 Brazilian patients with disseminated cryptococcosis showed that 75 were C. neoformans var. neoformans and 8 were var. gattii. Twenty-seven isolates were serotyped; all 19 var. neoformans were serotype A and all 8 var. gattii were serotype B. The correlation of the varieties of C. neoformans with the presence or not of hosts predisposing conditions to the mycosis showed that: (1) cryptococcosis caused by gattii variety occurred in 7 (58.3%) of the 12 nonimmunosuppressed patients, and (2) cryptococcosis caused by neoformans variety occurred in 65 (98.5%) of the 66 AIDS patients and in all 5 patients with other immunosuppressive conditions. The comparison of the distribution of the gattii and neoformans varieties between the nonimmunosuppressed and immunosuppressed patients showed a significant statistical difference (p < 0.01).
authors.affiliation: Serviço de Doenças Infecciosas e Parasitarárias, Hospital dos Servidores do Estado, Rio de Janeiro, Brasil.
authors.forename: R
authors.initials: R
authors.lastname: Rozenbaum
authors.forename: A J
authors.initials: AJ
authors.lastname: Gonçalves
authors.forename: B
authors.initials: B
authors.lastname: Wanke
authors.forename: M J
authors.initials: MJ
authors.lastname: Caiuby
authors.forename: H
authors.initials: H
authors.lastname: Clemente
authors.forename: M dos S
authors.initials: Mdos S
authors.lastname: Lazera
authors.forename: P C
authors.initials: PC
authors.lastname: Monteiro
authors.forename: A T
authors.initials: AT
authors.lastname: Londero
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D001938:Brazil; D003453:Cryptococcosis / Q000276:immunology / Q000382:microbiology*; D003455:Cryptococcus neoformans / Q000145:classification*; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008297:Male