title: Pulmonary function in a non-pulsatile pulmonary circulation.
abstract: The authors suggested that a mammal immediately accommodates well to nonpulsatile flow in the systemic circulation. In the current study, nonpulsatile pulmonary blood flow using a centrifugal pump was established in chronic models to analyze its influence on the pulmonary circulation. A pulsatile right ventricular assist device (RVAD) was implanted to draw blood from both the right atrium and ventricle and send blood to the pulmonary artery in six goats. After 2 weeks, the pulsatile pump was quickly replaced with a centrifugal pump without anesthesia, and a 100% non-pulsatile pulmonary blood flow was obtained. Cardiac output was kept at 80-120 ml/kg/min during the experiments. No changes were observed in hemodynamic parameters, including pulmonary arterial pressure, pulmonary vascular resistance index, and blood gas data, after the immediate depulsation of the pulmonary blood flow. There was also no significant change in the ventral to dorsal tissue blood flow ratio of the lower lobe of the right lung, which was calculated by a colored microsphere method, between pulsatile and non-pulsatile pulmonary blood perfusion. These results suggest that pulmonary function, including blood flow distribution, is not affected by non-pulsatile pulmonary circulation for periods up to 14 days.
authors.affiliation: Department of Artificial Organs, National Cardiovascular Research Institute, Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Sakaki
authors.forename: Y
authors.initials: Y
authors.lastname: Taenaka
authors.forename: E
authors.initials: E
authors.lastname: Tatsumi
authors.forename: T
authors.initials: T
authors.lastname: Nakatani
authors.forename: M
authors.initials: M
authors.lastname: Kinoshita
authors.forename: H
authors.initials: H
authors.lastname: Akagi
authors.forename: T
authors.initials: T
authors.lastname: Masuzawa
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuo
authors.forename: K
authors.initials: K
authors.lastname: Inoue
authors.forename: Y
authors.initials: Y
authors.lastname: Baba
mesh_terms: D000818:Animals; D001794:Blood Pressure; D005069:Evaluation Studies as Topic; D006041:Goats; D006353:Heart-Assist Devices / Q000009:adverse effects; D008863:Microspheres; D010100:Oxygen / Q000097:blood; D011474:Prosthesis Design; D011652:Pulmonary Circulation / Q000502:physiology*; D012039:Regional Blood Flow; D014655:Vascular Resistance
chemical_list: D010100:Oxygen