title: [Use of thermo- and acid-stable proteinase inhibitor to suppress proteolytic activation in pulmonary inflammation].
abstract: A comparative study of thermo-acid stable proteinase inhibitor from rabbit serum and commercial drug contrykal was made on rats and in vitro experiments. Both inhibitors in equal doses effectively suppress proteolytic activity during initiation of lung inflammation. It was shown that the thermo-acid stable inhibitor possesses higher than contrykal, antielastase activity. A high effect of the acid stable inhibitors in the treatment of lung disease is suggested.
authors.forename: A V
authors.initials: AV
authors.lastname: Kubyshkin
authors.forename: O G
authors.initials: OG
authors.lastname: Ogloblina
mesh_terms: D000818:Animals; D004789:Enzyme Activation; D007249:Inflammation; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008171:Lung Diseases / Q000201:enzymology*; D010447:Peptide Hydrolases / Q000378:metabolism*; D011480:Protease Inhibitors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D011480:Protease Inhibitors; D010447:Peptide Hydrolases
vernacular_title: Ispol'zovanie termo- i kislotostabil'nogo ingibitora proteinaz dlia podavleniia aktivatsii proteoliza pri vospalenii legkikh.