[Changes in the structure and reactions of lipid peroxidation of liver chromatin as affected by 0,0-dimethyl-0,2,2-dichlorovinylphosphate].
Intoxication of rats by 0,0-dimethyl-0-2,2-dichlorovinylphosphate (DDVPh) leads to marked biochemical changes of transcriptionally active (TACh) and repressed (RCh) liver chromatin fractions. These changes are connected with structural relaxation of the fractions, which is manifested by the increase of intensity of protein self-fluorescence. Free radical nature of these changes was supposed, which was proved by the modification of LPO reactions in the both chromatin fractions under the influence of the pesticide concerned.
Gubskiĭ
Iu I
IuI
Levitskiĭ
E L
EL
Primak
R G
RG
Lenchevskaia
L K
LK
D000818:Animals; D002843:Chromatin / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D004006:Dichlorvos / Q000506:poisoning*; D005260:Female; D005609:Free Radicals; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013050:Spectrometry, Fluorescence; D014158:Transcription, Genetic / Q000187:drug effects
D002843:Chromatin; D005609:Free Radicals; D008315:Malondialdehyde; D004006:Dichlorvos
Izmeneniia struktury i reaktsiĭ lipopereokisleniia khromatina pecheni pod vliianiem 0,0-dimetil-0,2,2-dikhlorovinilfosfata.