[Influence of delta-sleep-inducing peptide on the activity of proteolytic enzymes in the rat brain under hypokinesia].
Single administration of the delta-sleep-inducing peptide (DSIP) in a dose of 12 micrograms/100 g to intact animals makes the activity of neutral proteinases and cathepsin D higher in the rat brain and blood serum. Hypokinesia of different duration changes activity of neutral and acidic proteinases and induces accessibility of cathepsin D to the cytosol as a result of damage in lysosomal membrane. Injection DSIP induces a decrease A/B of cathepsin D to the control level under 1-h hypokinesia condition and normalizes the neutral proteolytic activity under 6-h hypokinesia condition.
Mendzheritskiĭ
A M
AM
Lysenko
A V
AV
Mikhaleva
I I
II
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D002402:Cathepsin D / Q000097:blood / Q000187:drug effects / Q000378:metabolism; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology*; D005260:Female; D008297:Male; D010447:Peptide Hydrolases / Q000097:blood / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D012016:Reference Values; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000201:enzymology*
D003701:Delta Sleep-Inducing Peptide; D010447:Peptide Hydrolases; D002402:Cathepsin D
Vliianie del'ta-son-indutsiruiushchego peptida na aktivnost' proteoliticheskikh fermentov v mozge krys pri gipokinezii.