The effect of captopril on glucoheptonate uptake in experimental renal artery stenosis.
This study attempted to evaluate the role of glucoheptonate (GHA) in captopril renography in an in vivo laboratory investigation in which postcaptopril glucoheptonate uptake was analysed in awake 2KlC hypertensive rats. Clamped kidney uptake in a previous study was greater in the poststenotic kidney than in the normal kidney (P = 0.01) in rats with mild renal artery stenosis. A glucoheptonate renogram protocol was developed for use in rats anaesthetized with sodium pentobarbital. An 123I-hippuran scan was performed to determine the relative renal function, followed by a control 99Tcm-GHA scan. Five minutes after administering captopril, another 99Tcm-GHA scan was performed. Relative renal uptake was determined between 30 and 90 s postinjection. 99Tcm-GHA uptake in the clamped kidney was more than 50% of total uptake in 3/9 of the abnormal rats' control scans. No abnormal rats clamped kidney 99Tcm-GHA uptake was greater than 50% in the postcaptopril scans. Captopril reduced GHA uptake in all nine of the animals with baseline scans. These findings suggest that the laboratory observation of captopril induced paradoxically increased 99Tcm-GHA uptake in renal artery stenosis may not be observed scintirenographically. Moreover, the data support a potential value of glucoheptonate in captopril renography.
Gale
B
B
Department of Nuclear Medicine, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York 10461.
Zhang
C
C
Lee
H B
HB
Heller
S
S
Blaufox
M D
MD
D000818:Animals; D002216:Captopril / Q000494:pharmacology*; D006978:Hypertension, Renovascular / Q000000981:diagnostic imaging / Q000378:metabolism*; D007465:Iodohippuric Acid; D008297:Male; D015609:Organotechnetium Compounds; D011866:Radioisotope Renography; D051381:Rats; D017207:Rats, Sprague-Dawley; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging / Q000378:metabolism*; D013400:Sugar Acids / Q000493:pharmacokinetics*
D015609:Organotechnetium Compounds; D013400:Sugar Acids; D007465:Iodohippuric Acid; D002216:Captopril; C007852:alpha-glucoheptonic acid; C100014:technetium Tc 99m gluceptate