Trans-activation by hepatitis B virus X protein is mediated via a tumour promoter pathway.
We have studied the c-myc gene as a possible target of HBV X protein in liver carcinogenesis. Our results indicate that trans-activation by X protein occurs via PKC/AP1 signal transduction, suggesting a possible two-step mechanism in HBV related liver carcinogenesis.
Kekulé
A S
AS
Max-Planck-Institut für Biochemie, Martinsried, Federal Republic of Germany.
Lauer
U
U
Weiss
L
L
Hofschneider
P H
PH
Koshy
R
R
D002478:Cells, Cultured; D016259:Genes, myc / Q000235:genetics; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology; D011493:Protein Kinase C / Q000378:metabolism; D015398:Signal Transduction; D015534:Trans-Activators / Q000235:genetics*; D015533:Transcriptional Activation; D054334:Viral Regulatory and Accessory Proteins
D015534:Trans-Activators; D054334:Viral Regulatory and Accessory Proteins; C057628:hepatitis B virus X protein; D011493:Protein Kinase C