Copper (II) complexes as a laccase model in the catalytic removal of the phenylhydrazide protecting group under mild oxidative conditions.
Copper (II) complexes, with nitrogen-containing ligands (pyridine and imidazole), simulate perfectly the catalytic activity of laccase in the oxidative removal of the phenylhydrazide protecting group. Deblocking occurs under mild conditions, preventing the oxidation of labile amino acids. The effect of certain factors on the rate of deblocking and the degree of conversion were studied, and optimal conditions providing 100% yield of the deblocked products were chosen.
Semenov
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AN
Russian-German Joint Venture Constanta, Moscow, Russia.
Lomonosova
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IV
Titov
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MI
D000595:Amino Acid Sequence; D001665:Binding Sites; D003300:Copper / Q000737:chemistry*; D007700:Kinetics; D042845:Laccase; D008956:Models, Chemical; D008969:Molecular Sequence Data; D008970:Molecular Weight; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000737:chemistry*; D010659:Phenylhydrazines / Q000737:chemistry*; D012997:Solvents
D010659:Phenylhydrazines; D012997:Solvents; D003300:Copper; D010088:Oxidoreductases; D042845:Laccase