Inhalation kinetics of C6 to C10 aliphatic, aromatic and naphthenic hydrocarbons in rat after repeated exposures.
The toxicokinetic properties of C6 to C10 n-alkanes, aromates and naphthenes have been investigated in rats during inhalation of 100 p.p.m. of the single hydrocarbons for 3 days, 12 hr/day. The concentration of hydrocarbon was measured by head space gas chromatography in blood, brain, liver, kidneys and perirenal fat at days 1, 2 and 3, immediately after termination of exposure and 12 hr after exposure on day 3. The main conclusions drawn from the study were: a) Aromatic hydrocarbons show high concentrations in blood and low concentrations in organs. b) Naphthenic hydrocarbons show low concentrations in blood and high concentrations in organs. c) n-Alkanes show very low concentrations in blood, relatively high concentrations in brain and a high potential for accumulation in fat with repeated exposures. d) Biological concentrations of hydrocarbons within one class increase in general with increasing molecular weight, though with specific exceptions. e) Accumulation is obviously influenced by differences in metabolism and enzyme induction potential. f) Lipid solubility is not the only parameter relevant for the evaluation of hydrocarbon accumulation.
Zahlsen
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Department of Pharmacology and Toxicology, University Medical Centre, Trondheim, Norway.
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Nilsen
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Nilsen
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D000273:Adipose Tissue / Q000378:metabolism; D000280:Administration, Inhalation; D000473:Alkanes / Q000493:pharmacokinetics; D000818:Animals; D001921:Brain / Q000378:metabolism; D002849:Chromatography, Gas; D003516:Cycloparaffins / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity; D006838:Hydrocarbons / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D011083:Polycyclic Compounds / Q000493:pharmacokinetics / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley
D000473:Alkanes; D003516:Cycloparaffins; D006838:Hydrocarbons; D011083:Polycyclic Compounds