Venesection in haemoglobin Yakima, a high oxygen affinity haemoglobin.
High oxygen affinity haemoglobins result in polycythaemia and cardiovascular adaptation to maintain tissue oxygenation. The polycythaemia can cause symptoms of hyperviscosity and vaso-occlusive disease. We report a kindred with a high affinity haemoglobin (Haemoglobin Yakima) one of whose members gave birth to two infants with intra-uterine growth retardation and who suffered with symptoms of hyperviscosity which settled on reduction of the PCV by venesection.
Grace
R J
RJ
Department of Haematology, St. Thomas' Hospital, London, UK.
Gover
P A
PA
Treacher
D F
DF
Heard
S E
SE
Pearson
T C
TC
D000293:Adolescent; D001815:Bloodletting; D002318:Cardiovascular Diseases / Q000097:blood / Q000235:genetics*; D005260:Female; D006455:Hemoglobins, Abnormal / Q000378:metabolism*; D006801:Humans; D010100:Oxygen / Q000097:blood*; D010375:Pedigree; D011086:Polycythemia / Q000097:blood / Q000235:genetics* / Q000601:surgery
D006455:Hemoglobins, Abnormal; C078525:hemoglobin Yakima; D010100:Oxygen