title: Reaction in leprosy: acute phase reactant response during and after remission.
abstract: Sera from 25 patients with type 1 (Lepra), upgrading and downgrading, and type 2 (erythema nodosum leprosum [ENL]) reactions were assayed, during the reaction and after its clinical remission, for changes in levels of alpha-1-antitrypsin (A1A) and C-reactive protein (CRP). The results were compared with those from normal healthy adults and patients of leprosy without history and/or clinical evidence of reaction. The A1A levels correlated better with changes in status of type 1 reaction; whereas CRP levels correlated well with alterations in type 2 reactions and were definitely superior to A1A in this situation for monitoring the course of these episodes.
authors.affiliation: Department of Dermatology, Lady Hardinge Medical College, New Delhi, India.
authors.forename: V N
authors.initials: VN
authors.lastname: Sehgal
authors.forename: S N
authors.initials: SN
authors.lastname: Bhattacharya
authors.forename: Y
authors.initials: Y
authors.lastname: Shah
authors.forename: V K
authors.initials: VK
authors.lastname: Sharma
authors.forename: C K
authors.initials: CK
authors.lastname: Gupta
mesh_terms: D000293:Adolescent; D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D004893:Erythema Nodosum / Q000097:blood* / Q000628:therapy; D005260:Female; D006801:Humans; D015439:Leprosy, Borderline / Q000097:blood* / Q000276:immunology / Q000628:therapy; D015440:Leprosy, Lepromatous / Q000097:blood* / Q000276:immunology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011930:Reaction Time; D012074:Remission Induction; D000515:alpha 1-Antitrypsin / Q000378:metabolism
chemical_list: D000515:alpha 1-Antitrypsin; D002097:C-Reactive Protein