title: Fatal disseminated infection caused by Myceliophthora thermophila, a new agent of mycosis: case history and laboratory characteristics.
abstract: We report a case of human infection caused by the hyphomycete Myceliophthora thermophila. A 7-year-old male with neurofibromatosis (type 1) was diagnosed in 1987 with acute myeloblastic leukemia associated with the chromosomal abnormality monosomy 7. The patient experienced multiple serious infections over a three-year period before expiring in 1990 while in the end stage of leukemia. Autopsy findings included fungal vegetations of the left atrium, ascending aorta, and pulmonary arteries and fungal invasion of both lungs. Cultures yielded M. thermophila. We believe that this is the first reported fatality caused by M. thermophila.
authors.affiliation: Department of Laboratory Medicine, Geisinger Medical Center, Danville, Pennsylvania 17822.
authors.forename: P
authors.initials: P
authors.lastname: Bourbeau
authors.forename: D A
authors.initials: DA
authors.lastname: McGough
authors.forename: H
authors.initials: H
authors.lastname: Fraser
authors.forename: N
authors.initials: N
authors.lastname: Shah
authors.forename: M G
authors.initials: MG
authors.lastname: Rinaldi
mesh_terms: D002648:Child; D004352:Drug Resistance, Microbial; D006801:Humans; D016867:Immunocompromised Host; D015470:Leukemia, Myeloid, Acute / Q000150:complications; D008297:Male; D003904:Mitosporic Fungi / Q000187:drug effects / Q000302:isolation & purification / Q000648:ultrastructure; D009181:Mycoses / Q000150:complications / Q000209:etiology*; D009456:Neurofibromatosis 1 / Q000150:complications; D009894:Opportunistic Infections / Q000150:complications / Q000209:etiology