title: Seasonal fluctuations in acute upper gastrointestinal bleeding: lack of effect of nonsteroidal anti-inflammatory drugs.
abstract: The seasonal pattern of community-based acute bleeding from the upper gastrointestinal (UGI) tract was studied prospectively in 1988-1991. Out of 3343 emergency admissions to the Departments of General Surgery, 321 (9.6%) were due to acute UGI bleeding. There was a significant monthly variation in the total number of admissions, as well as in the number of admissions due to acute UGI bleeding (p < 0.0001). However, there was no correlation between the two. Significant seasonal fluctuations were noted both in the absolute number of admissions due to acute UGI bleeding and in the percentage of UGI bleeding admissions of the total number of admissions to the Departments of General Surgery (p = 0.0002). During summer (July through September), the incidence declined significantly to a nadir of 5.5% of total number of admissions in July. The seasonal fluctuation correlated closely with the incidence of duodenal ulcer, but not with that of gastric ulcer. The seasonal pattern was consistent both in patients who had used aspirin or other nonsteroidal anti-inflammatory drugs as well as in those who had not.
authors.affiliation: Gastroenterology Unit, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: J
authors.initials: J
authors.lastname: Zimmerman
authors.forename: R
authors.initials: R
authors.lastname: Arnon
authors.forename: R
authors.initials: R
authors.lastname: Beeri
authors.forename: D
authors.initials: D
authors.lastname: Keret
authors.forename: J
authors.initials: J
authors.lastname: Lysy
authors.forename: M
authors.initials: M
authors.lastname: Ligumski
authors.forename: J
authors.initials: J
authors.lastname: Gonzalez
authors.forename: A
authors.initials: A
authors.lastname: Fich
authors.forename: Z
authors.initials: Z
authors.lastname: Ackerman
authors.forename: E
authors.initials: E
authors.lastname: Goldin
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects; D004381:Duodenal Ulcer / Q000150:complications / Q000188:drug therapy; D004630:Emergencies; D004941:Esophagitis / Q000150:complications / Q000188:drug therapy; D005756:Gastritis / Q000150:complications / Q000188:drug therapy; D006471:Gastrointestinal Hemorrhage / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D015994:Incidence; D007557:Israel / Q000453:epidemiology; D011446:Prospective Studies; D012621:Seasons; D013276:Stomach Ulcer / Q000150:complications / Q000188:drug therapy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin