title: Renal function after hip arthroplasty and isoxazolylpenicillin prophylaxis.
abstract: Two different isoxazolylpenicillins (cloxacillin and dicloxacillin) were compared regarding impairment of renal function after total hip arthroplasty. 85 patients received dicloxacillin and 93 patients received cloxacillin as antibiotic prophylaxis. A total dose of 6 grams was given during a 36-hour period in doses of 1 gram pre-, per- and postoperatively. Creatinine in serum and beta 2-microglobulin in serum and urine were determined preoperatively and 2, 4, and 10 days after the operation. The dicloxacillin-treated patients had an increase in creatinine and beta 2-microglobulin in serum that was not seen in the cloxacillin group. The increase indicates a transient injury in the process of glomerular filtration. Although the increase was temporary and subclinical, a dose reduction is nevertheless recommended for older patients.
authors.affiliation: Department of Orthopedics, Faculty of Health Sciences, Linköping University Hospital, Sweden.
authors.forename: O
authors.initials: O
authors.lastname: Wahlström
authors.forename: R
authors.initials: R
authors.lastname: Maller
authors.forename: K
authors.initials: K
authors.lastname: Djerf
authors.forename: I
authors.initials: I
authors.lastname: Ivarsson
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use; D003023:Cloxacillin / Q000008:administration & dosage / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D004009:Dicloxacillin / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006622:Hip Prosthesis; D006785:Hospitals, University; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology; D011292:Premedication / Q000009:adverse effects* / Q000379:methods; D011446:Prospective Studies; D013548:Sweden / Q000453:epidemiology; D001613:beta 2-Microglobulin / Q000032:analysis / Q000652:urine
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001613:beta 2-Microglobulin; D003404:Creatinine; D004009:Dicloxacillin; D003023:Cloxacillin; D001241:Aspirin