title: Pharmacology of the 5-hydroxytryptamine-induced depolarization of the ferret vagus nerve in vitro.
abstract: Grease-gap recordings revealed that 5-hydroxytryptamine (5-HT) depolarized the ferret vagus nerve (pEC50 = 4.9). This response was mimicked by 2-methyl-5-HT and 1-phenylbiguanide, but not by 5-carboxamidotryptamine. Paroxetine (1 microM) or ketamine (10 microM) did not potentiate the response. Ketanserin (1 microM) did not reduce the depolarization, but four 5-HT3 receptor antagonists did. It is concluded that 5-HT depolarizes the ferret vagus nerve via 5-HT3 receptors, but these receptors may differ pharmacologically from those in other species.
authors.affiliation: Oxford University, SmithKline Beecham Centre for Applied Neuropsychobiology, Department of Clinical Pharmacology, Radcliffe Infirmary, UK.
authors.forename: N R
authors.initials: NR
authors.lastname: Newberry
authors.forename: C J
authors.initials: CJ
authors.lastname: Watkins
authors.forename: D J
authors.initials: DJ
authors.lastname: Reynolds
authors.forename: R A
authors.initials: RA
authors.lastname: Leslie
authors.forename: D G
authors.initials: DG
authors.lastname: Grahame-Smith
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005289:Ferrets; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000031:analogs & derivatives / Q000494:pharmacology*; D014403:Tubocurarine / Q000494:pharmacology; D014630:Vagus Nerve / Q000187:drug effects* / Q000502:physiology
chemical_list: D011985:Receptors, Serotonin; D012701:Serotonin; C045918:2-methyl-5-HT; D014403:Tubocurarine