title: [Hemorrhage of the brain after therapeutic fibrinolysis. 11 cases].
abstract: Ten cases of cerebral hemorrhage and one of intraspinal subdural hematoma after thrombolytic therapy are reported. Six patients were treated with streptokinase, four with rt-PA and one with a combination of both drugs. The incidence was 0.5 to 2% and was higher in case of rt-PA therapy (3.7%). In all cases, CT scan showed primary hemorrhage rather than hemorrhagic infarction. Four patients died of stroke. Among the survivors, residual disability was severe in one and mild in five. Only one patient recovered completely. In patients treated with streptokinase, the hemorrhage was probably due to a more than 80% decrease in plasma fibrinogen. In those receiving rt-PA, either excessive dosage (2 cases in our series) or lysis of cerebral microthrombi are thought to be responsible for the hemorrhagic complications. Treatment consists of infection of aprotinin (an anti-fibrinolytic drug), cryoprecipitates with factors V and VIII and protamine sulfate.
authors.affiliation: Service de Neurologie, CHRU Gui de Chauliac, Montpellier.
authors.forename: J M
authors.initials: JM
authors.lastname: Blard
authors.forename: M
authors.initials: M
authors.lastname: Vastene
authors.forename: R
authors.initials: R
authors.lastname: Labauge
authors.forename: J Y
authors.initials: JY
authors.lastname: Beigbeder
authors.forename: P
authors.initials: P
authors.lastname: Messner-Pellenc
authors.forename: M
authors.initials: M
authors.lastname: Pagès
authors.forename: R
authors.initials: R
authors.lastname: Grolleau-Raoux
mesh_terms: D000368:Aged; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy; D010960:Plasminogen Activators / Q000627:therapeutic use; D011379:Prognosis; D011655:Pulmonary Embolism / Q000188:drug therapy; D013300:Streptokinase / Q000627:therapeutic use; D015912:Thrombolytic Therapy / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed
chemical_list: D013300:Streptokinase; D010960:Plasminogen Activators
vernacular_title: Hémorragies du système nerveux central après fibrinolyse thérapeutique. 11 Cas.