Creatine kinase (CK) and creatine kinase isoenzyme (CK-MB) activity in serum before and after intravenous salbutamol administration of patients with bronchial asthma.
The effect of salbutamol, a selective beta 2-adrenergic agonist, on creatine kinase (CK) and creatine kinase isoenzyme (CK-MB) activity in serum of 20 asthmatic patients was investigated. Venous blood was obtained 30 min, 2 h and 4 h after 0.5 mg salbutamol intravenous injection of 0.5 mg salbutamol. Total creatine kinase activity was assayed on a Technico RA-1000 analyzer with the IFCC recommended method. CK-MB activity was determined using a centrifugal analyzer (Cobas Fera, Roche, Switzerland). Reagent kits were provided by Boehringer Mannheim (FRG). We observed no increase of CK-activity after salbutamol, and found a statistically significant increase of CK-MB activity. Serum CK-MB activity before treatment was 13 +/- 10/IU/l after 30 minutes drug, 31.8 +/- 19 IU/l after 2 h 27.2 +/- 17.79 and after 4 h 22.6 +/- 12 IU/l. We conclude that salbutamol exerts a cardiotoxic effect.
Chazan
R
R
Department of Pneumology, Warsaw University Medical School, Poland.
Tadeusiak
W
W
Jaworski
A
A
Droszcz
W
W
D000328:Adult; D000420:Albuterol / Q000008:administration & dosage / Q000494:pharmacology*; D001249:Asthma / Q000201:enzymology*; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006321:Heart / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000201:enzymology
D007527:Isoenzymes; D003402:Creatine Kinase; D000420:Albuterol