[Fructose metabolism disorders and infusions].
The authors give an account of views regarding the use of non-glucose energy sources in parenteral nutrition during the immediate post-load period/serious operations, severe injuries). Attention is devoted to the metabolic pathway of fructose and its disorders. In hereditary fructose intolerance an infusion of D-fructose or D-glucitol (= sorbitol) can induce life threatening hypoglycaemia (unless glucose is administered concurrently). According to some views, in subjects with this intolerance the organism is threatened also by hepatic and renal failure; their development may be independent on hypoglycaemia. Fructose and D-glucitol (sorbitol) therefore should not be administered by the parenteral route. This view is supported by cases where hereditary fructose intolerance could not be revealed from the case-history and clinical manifestations. Some countries have already eliminated fructose and D-glucitol (sorbitol) from their pharmacopoeias.
Palyza
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Biochemický ústav. Lékarská fakulta MU, Brno.
Bocková
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M
D005526:Food, Formulated / Q000009:adverse effects; D005632:Fructose / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism*; D015318:Fructose Metabolism, Inborn Errors / Q000378:metabolism; D006801:Humans; D010288:Parenteral Nutrition / Q000009:adverse effects; D013012:Sorbitol / Q000008:administration & dosage / Q000009:adverse effects
D005632:Fructose; D013012:Sorbitol
Poruchy metabolismu fruktózy a infúze.