Induction of follicle formation and hair growth by vibrissa dermal papillae implanted into rat ear wounds: vibrissa-type fibres are specified.
Adult vibrissa follicle dermal papillae have the capacity to induce hair growth and follicle formation when associated with epidermis from various sources. However, the range of conditions under which hair follicle induction will take place has not been established. The question of whether or not the adult papilla carries information to impose fibre-type specificity has also not been fully answered. This study describes how the implantation of isolated papillae into small incisional cuts on the rat ear pinna resulted in the subsequent emergence of abnormally large hair fibres from the wound sites. Many of these hairs were found to display vibrissa-type characteristics. Histological observations indicated that the papillae had interacted with the edges of the wound epidermis to produce new, and particularly large follicles, while immunohistochemical staining revealed that early follicle construction was accompanied by a profusion of the basement membrane constituents laminin and type IV collagen in the subjacent dermis. These findings show that adult rat papillae retain the capacity, as displayed by embryonic dermis, to determine vibrissa specificity in induced follicles.
Jahoda
C A
CA
Department of Biological Sciences, University of Dundee, Scotland, UK.
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D003094:Collagen / Q000378:metabolism; D004423:Ear; D004817:Epidermis / Q000473:pathology*; D007150:Immunohistochemistry; D007797:Laminin / Q000378:metabolism; D051381:Rats; D012867:Skin / Q000378:metabolism; D014738:Vibrissae / Q000033:anatomy & histology / Q000254:growth & development / Q000502:physiology* / Q000637:transplantation; D014947:Wounds and Injuries / Q000473:pathology*
D007797:Laminin; D003094:Collagen