[Mucus models for investigation of intestinal absorption mechanisms. 2. Mechanisms of drug interactions with intestinal mucus].
Using in vitro models previously described [1] mucus retention and mucus diffusion of polar and non-polar drugs were measured. It could be shown that drug interaction with pig intestinal mucus was based on non-specific binding. The pH-dependence of retention by mucus does not confirm electrostatic interaction of drugs with mucus but favour drug distribution to hydrophobic areas within the mucus. High lipophilicity and retention by mucus correlate with low diffusion of drugs through mucus.
Matthes
I
I
Pharmazeutische Entwicklung, Sandoz Pharma AG, Basel, Schweiz.
Nimmerfall
F
F
Sucker
H
H
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption / Q000502:physiology*; D007413:Intestinal Mucosa / Q000378:metabolism / Q000502:physiology*; D008024:Ligands; D008954:Models, Biological; D008970:Molecular Weight; D009093:Mucus / Q000737:chemistry / Q000502:physiology*
D008024:Ligands
Mucusmodelle zur Untersuchung von intestinalen Absorptions-mechanismen. 2. Mitteilung: Mechanismen der Wechselwirkung von Wirkstoffen mit Intestinalmucus.