title: [Disclosure of protein C deficiency with pulmonary embolism followed by cardiac arrest during the recovery period].
abstract: A case of unexpected cardiac arrest occurring in a 17-year-old male patient is reported. The patient had been admitted after sustaining hand trauma. A first emergency surgical procedure was carried out, followed about three weeks later by another one. No incidents occurred during or after either of these two operations. A third procedure was required about two months after the accident (free toe graft to the thumb of the left hand). The twelve-hour operation was carried out under general anaesthesia and axillary block. The patient was given intravenous heparin (800 IU.h-1) during the procedure on the arm. The patient recovered quickly, and was extubated before his transfer to the recovery room. Fifteen minutes later, the patient's heart rate decreased to 40 b.min-1, followed by a transient cardiorespiratory arrest. The suspicion of pulmonary embolism was confirmed by pulmonary scintigraphy. Thrombolysis was carried out with 2,000 IU.kg-1.h-1 of urokinase for a 72 h period, combined with continuous heparin administration (16 to 36 x 10(3) IU.day-1). The patient recovered after one week. No thrombophlebitis was found for origin of the emboli. Biological investigations carried out both before and after 10 minutes of anoxia revealed a normal fibrinolytic system, but a deficit in protein C (62% antigen, 64% activity). Two years after the episode of pulmonary embolism, the patient, still taking acenocoumarol, remained free from any sequela. Current perioperative management of patients with a known protein C deficit is discussed.
authors.affiliation: Département d'Anesthésie-Réanimation, CHRU de Brest.
authors.forename: J P
authors.initials: JP
authors.lastname: Delalande
authors.forename: D
authors.initials: D
authors.lastname: Sauvanaud
authors.forename: J F
authors.initials: JF
authors.lastname: Abgrall
authors.forename: D
authors.initials: D
authors.lastname: Rea
authors.forename: J P
authors.initials: JP
authors.lastname: Egreteau
mesh_terms: D000328:Adult; D000762:Anesthesia Recovery Period; D001778:Blood Coagulation Disorders / Q000150:complications* / Q000235:genetics; D006323:Heart Arrest / Q000209:etiology*; D006801:Humans; D008297:Male; D010375:Pedigree; D011183:Postoperative Complications; D020151:Protein C Deficiency; D011655:Pulmonary Embolism / Q000209:etiology*
vernacular_title: Révélation d'un déficit en protéine C par une embolie pulmonaire suivie d'un arrêt cardiaque en phase de réveil.