Immunopathology in Aujeszky's disease virus-infected pigs exposed to fluctuating temperatures.
Pigs exposed to fluctuating temperatures (high, 30 +/- 2 degrees C; low, 4 +/- 1 degrees C) were intranasally inoculated with Aujeszky's disease virus (ADV). ADV-infected pigs, exposed to the fluctuating temperatures, showed severe clinical signs and ADV in the nasal secretions persisted longer than in the ADV-infected control pigs kept at the normal temperature (20 +/- 2 degrees C). High concentrations of ADV were isolated from nasal secretions on the 1st day after inoculation of the virus. Pathologically, all ADV-infected pigs had non-suppurative encephalitis and trigeminal ganglionitis. The lesions were more widely distributed in pigs exposed to fluctuating temperatures than in infected control pigs. Two infected pigs given the stress had severe malacic foci in the frontal lobe and four of them had prominent interstitial pneumonia. In the pigs exposed to fluctuating temperatures, a significant number of immunoglobulin-containing cells, especially IgM-containing cells, did not respond to ADV infection. A significant (P < 0.01) difference in the number of IgG- and IgM-containing cells was observed between the ADV-infected pigs exposed to the fluctuating temperature and ADV-infected control pigs, respectively. These results demonstrated that the stress of fluctuating temperatures enhanced the susceptibility to ADV infection.
Narita
M
M
National Institute of Animal Health, Ibaraki, Japan.
Nanba
K
K
Haritani
M
M
Kawashima
K
K
D000818:Animals; D004198:Disease Susceptibility; D004679:Encephalomyelitis / Q000382:microbiology / Q000473:pathology / Q000662:veterinary; D005122:Exudates and Transudates / Q000382:microbiology; D005625:Frontal Lobe / Q000382:microbiology / Q000473:pathology; D016867:Immunocompromised Host; D009296:Nasal Cavity / Q000382:microbiology; D011024:Pneumonia, Viral / Q000382:microbiology / Q000473:pathology / Q000662:veterinary; D011557:Pseudorabies / Q000209:etiology / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D011658:Pulmonary Fibrosis / Q000382:microbiology / Q000473:pathology / Q000662:veterinary; D013312:Stress, Physiological / Q000150:complications / Q000276:immunology / Q000662:veterinary; D013552:Swine; D013696:Temperature