title: Blood pressure responses to LBNP in nontrained and trained hypertensive rats.
abstract: To study the influences of 16 wk of endurance training on the reflex regulation of resting blood pressure, nontrained (NT) and trained (T) female hypertensive rats (SHR) were subjected to conditions of lower body negative pressure (LBNP). Measurements of muscle cytochrome oxidase activity and run time to exhaustion indicated that the animals were endurance trained. The rats (NT = 6, T = 7) were tranquilized with 300-600 micrograms.kg-1 diazepam (IV) before heart rates and blood pressures were measured over a range of 2.5-10.0 mm Hg of negative pressure. When subjected to conditions of LBNP, the reflex tachycardia of the T group was greater than the NT at the lower (-2.5 and -5.0 mm Hg) negative pressures. Although arterial pressure declines were similar in both groups, the T group experienced significantly less of a decline in central venous pressure than the NT animals. When chlorisondamine was used as a ganglionic blocker (2.5 mg.kg-1, IV), the fall in CVP at 10 mm Hg negative pressure was greater for the NT group while the fall in the initial systemic arterial pressure was more for the T group. From these results we concluded that training had altered the interaction between cardiopulmonary and arterial baroreflexes in these hypertensive rats and a nonneural component had been altered such as cardiac function.
authors.affiliation: Department of Exercise and Movement Science, University of Oregon, Eugene 97403.
authors.forename: T G
authors.initials: TG
authors.lastname: Bedford
authors.forename: C M
authors.initials: CM
authors.lastname: Tipton
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002496:Central Venous Pressure; D005260:Female; D006339:Heart Rate; D006973:Hypertension / Q000503:physiopathology*; D008150:Lower Body Negative Pressure; D010805:Physical Conditioning, Animal; D005082:Physical Exertion; D051381:Rats; D011918:Rats, Inbred SHR