A continuing signal maintains NGF receptor expression in hypoglossal motor neurons after crush injury.
Inhibition of axonal transport by vincristine applied to hypoglossal nerves 7 days after crush injury turns off the usual injured-induced expression of low affinity nerve growth factor receptor (p75NGFr). Vincristine applied proximal but not distal to the crush prevents p75NGFr induction. These results indicate that a continuing signal is axonally transported from the crush site that induces and maintains p75NGFr expression by injured motor neurons.
Greeson
D M
DM
Neurology Department, DVAMC, Nashville, TN 37212-2637.
Moix
L
L
Meier
M
M
Armstrong
D M
DM
Wiley
R G
RG
D000818:Animals; D007002:Hypoglossal Nerve / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009046:Motor Neurons / Q000187:drug effects / Q000378:metabolism*; D009409:Nerve Crush; D051381:Rats; D017207:Rats, Sprague-Dawley; D017475:Receptors, Nerve Growth Factor / Q000187:drug effects / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D014750:Vincristine / Q000494:pharmacology
D017475:Receptors, Nerve Growth Factor; D014750:Vincristine