[The enhanced efficacy of the pharmacological regulation of the processes of blood cell activation and interaction in the flow by polymer additives decreasing the hydrodynamic resistance of the blood].
The increase of blood cell auto- and interactivation and the decrease of aspirin antiaggregant effect were demonstrated under hemodynamic conditions of a stenotic zone in a model maximally approached to the real blood circulation. The lowering of platelet activation, of the release of active agents from platelets, and of platelet-leukocyte interactivation was attained under the conditions of the flow modified by the drag-reducing polymer solution. The recovery of aspirin antiaggregant activity and aspirin-induced reduction of the total platelet release of platelet- and leukocyte-activating agents were demonstrated under the influence of the polymer.
Akopov
S E
SE
Konorova
I L
IL
Grigorian
M R
MR
Gabrielian
E S
ES
Gannushkina
I V
IV
D001241:Aspirin / Q000031:analogs & derivatives / Q000494:pharmacology; D001783:Blood Flow Velocity / Q000187:drug effects*; D001809:Blood Viscosity / Q000187:drug effects*; D002450:Cell Communication / Q000187:drug effects*; D003094:Collagen / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D008239:Lysine / Q000031:analogs & derivatives / Q000494:pharmacology; D008961:Models, Structural; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D015539:Platelet Activation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000494:pharmacology*
D010975:Platelet Aggregation Inhibitors; D011092:Polyethylene Glycols; D009240:N-Formylmethionine Leucyl-Phenylalanine; D003094:Collagen; D008239:Lysine; D001241:Aspirin; C010395:acetylsalicylic acid lysinate
Povyshenie éffektivnosti farmakologicheskoĭ reguliatsii protsessov aktivatsii i vzaimodeĭstviia kletok krovi v potoke polimernymi dobavkami, snizhaiushchimi gidrodinamicheskoe soprotivlenie krovi.