title: Effect of hyperprolactinemia on the androgen response to an oral glucose load.
abstract: OBJECTIVE
  To investigate the effect of hyperprolactinemia on the androgen response to an oral glucose load in patients with normal and abnormal carbohydrate metabolism.
  
  
  METHODS
  Sixty-three women underwent a 75-g oral glucose tolerance test (OGTT) at approximately 6 weeks' postpartum.
  
  
  METHODS
  University hospital setting.
  
  
  METHODS
  Patients with a previous history of gestational diabetes.
  
  
  METHODS
  Adrenal and ovarian androgen response to oral glucose load.
  
  
  RESULTS
  Results were stratified by the result of the OGTT (patients with impaired glucose tolerance or diabetes as a single group and patients with a normal OGTT as a separate group) and prolactin (PRL) level. All androgens decreased significantly over the 2-hour test in all groups except dehydroepiandrosterone sulfate (DHEAS) in the patients with both elevated PRL and abnormal glucose tolerance.
  
  
  CONCLUSIONS
  Hyperprolactinemia and insulin resistance may act synergistically in the adrenal to alter DHEAS suppression and may result in chronically elevated circulating DHEAS levels.
authors.affiliation: Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
authors.forename: T
authors.initials: T
authors.lastname: Falcone
authors.forename: S
authors.initials: S
authors.lastname: Meltzer
authors.forename: D
authors.initials: D
authors.lastname: Morris
mesh_terms: D000328:Adult; D000728:Androgens / Q000097:blood*; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate; D016640:Diabetes, Gestational / Q000097:blood; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood*; D049590:Postpartum Period; D011247:Pregnancy
chemical_list: D000728:Androgens; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate