Repair of cervical nerve roots proximal to the root ganglia. An experimental study in sheep.
An experimental model was established to investigate the possibility of repairing cervical nerve roots damaged above the dorsal root ganglion, as occurs in traction injuries of the brachial plexus. In four sheep the C6 root was divided and repaired within the dura using freeze-thawed muscle grafts. Recovery was assessed after eight months by electrophysiology and histology. Action potentials were recorded distal to the grafts in all four sheep, indicating regeneration of motor fibres. Histological examination showed regenerated fibres in the ventral roots below the grafts in all cases. These fibres could be traced distally to the brachial plexus. There was no evidence of recovery of dorsal roots.
Hems
T E
TE
University of Edinburgh Medical School, Scotland.
Glasby
M A
MA
D000200:Action Potentials; D000818:Animals; D002574:Cervical Vertebrae; D005727:Ganglia, Spinal; D009416:Nerve Regeneration; D012756:Sheep; D013126:Spinal Nerve Roots / Q000166:cytology / Q000502:physiology / Q000601:surgery*