title: Thiopentone or propofol for induction of isoflurane-based anaesthesia for ambulatory surgery?
abstract: This study compares psychomotor recovery following induction of anaesthesia with either thiopentone or propofol in 30 healthy, unpremedicated patients undergoing outpatient arthroscopic procedures of the knee. A battery of tests including simple reaction time (SRT), choice reaction time (CRT), perceptive accuracy test (PAT) and digit symbol substitution test (DSST) were done before anaesthesia. The patients were randomly divided into two groups: Group 1 was induced with thiopentone 5-6 mg/kg while Group 2 was induced with propofol 2-3 mg/kg. Anaesthesia was then maintained with isoflurane (0.5-2%) in oxygen and air, and supplements of alfentanil were given for analgesia during spontaneous respiration with a face mask. Psychomotor recovery assessed every 30 min postoperatively for 120 min showed that patients in Group 1 had not returned to baseline values until 120 min after the operation on the PAT, while those in Group 2 had returned to baseline values at 60 min. No patient had any significant side effects. The SRT, CRT and DSST proved to be relatively insensitive in the detection of residual effects of anaesthesia and had a significant learning effect. This study suggests that induction of anaesthesia with propofol followed by maintenance with isoflurane in oxygen and air during spontaneous ventilation is associated with rapid psychomotor recovery and is a suitable method for ambulatory surgery. The PAT is sensitive and not associated with some of the problems found with other commonly used tests.
authors.affiliation: Department of Anaesthesia and Intensive Care, University Hospital, Linköping, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Gupta
authors.forename: L E
authors.initials: LE
authors.lastname: Larsen
authors.forename: F
authors.initials: F
authors.lastname: Sjöberg
authors.forename: M L
authors.initials: ML
authors.lastname: Lindh
authors.forename: C
authors.initials: C
authors.lastname: Lennmarken
mesh_terms: D000328:Adult; D015760:Alfentanil / Q000008:administration & dosage; D000556:Ambulatory Surgical Procedures; D000762:Anesthesia Recovery Period; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D001364:Awareness / Q000187:drug effects; D005260:Female; D006801:Humans; D007530:Isoflurane / Q000008:administration & dosage*; D008297:Male; D008568:Memory / Q000187:drug effects; D008875:Middle Aged; D009048:Motor Skills / Q000187:drug effects; D015742:Propofol / Q000008:administration & dosage / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects; D013874:Thiopental / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D015760:Alfentanil; D007530:Isoflurane; D013874:Thiopental; D015742:Propofol