title: Disease markers and new therapeutics. Dual objectives of genetics in rheumatology.
abstract: Genetic studies in rheumatology have led us down a path with two practical endpoints. On the one hand, sophisticated molecular genetics provides specific markers with which to predict disease risk. On the other hand, these same studies have identified likely genetic and molecular intermediates in the pathway of disease, offering new possibilities for targeted intervention and immunotherapy.
authors.affiliation: Immunology Program, Virginia Mason Research Center, Seattle, Washington.
authors.forename: G T
authors.initials: GT
authors.lastname: Nepom
mesh_terms: D005544:Forecasting; D005796:Genes; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005821:Genetic Techniques; D006801:Humans; D007125:Immunogenetics / Q000379:methods; D008967:Molecular Biology / Q000379:methods; D012216:Rheumatic Diseases / Q000235:genetics* / Q000628:therapy*; D012219:Rheumatology / Q000379:methods*
chemical_list: D005819:Genetic Markers