title: Fatal haemoptysis associated with invasive pulmonary aspergillosis treated with high-dose amphotericin B and granulocyte-macrophage colony-stimulating factor (GM-CSF).
abstract: Opportunistic pulmonary infections are a leading cause of morbidity and mortality in patients with chemotherapeutically treated neoplasias. With increasingly aggressive cytotoxic regimens causing prolonged neutropenia, the risk of systemic mycoses and in particular of invasive pulmonary aspergillosis has increased. We review the case of a 10-year-old child suffering from relapsed lymphoblastic leukaemia and from high-dose amphotericin B-treated invasive pulmonary aspergillosis acquired during long-standing neutropenia in the initial phase of remission induction chemotherapy. The patient died in remission after GM-CSF-induced bone marrow recovery and clinical and radiological improvement with stable plasmatic coagulation and normal thrombocyte count. Peracute massive pulmonary bleeding caused by the simultaneous arrosion of a greater pulmonary artery and a lobar bronchus by a liquefactive fungal focus was responsible. In patients with chemotherapeutically induced neutropenia and invasive aspergillosis, bone marrow recovery may lead to the liquefaction of pulmonary foci, and, in view of the well-known vasotropic nature of the infection, to a potentially lethal arrosion bleeding. With the emerging use of colony-stimulating factors for shortening and overcoming neutropenia, this so far rare complication may become of increasing importance.
authors.affiliation: Department of Pediatrics, J. W. Goethe-University, Frankfurt/Main, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Groll
authors.forename: S
authors.initials: S
authors.lastname: Renz
authors.forename: V
authors.initials: V
authors.lastname: Gerein
authors.forename: D
authors.initials: D
authors.lastname: Schwabe
authors.forename: G
authors.initials: G
authors.lastname: Katschan
authors.forename: M
authors.initials: M
authors.lastname: Schneider
authors.forename: K
authors.initials: K
authors.lastname: Hübner
authors.forename: B
authors.initials: B
authors.lastname: Kornhuber
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use*; D001228:Aspergillosis / Q000150:complications / Q000188:drug therapy*; D002648:Child; D004359:Drug Therapy, Combination; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006469:Hemoptysis / Q000209:etiology*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000150:complications / Q000188:drug therapy*; D009894:Opportunistic Infections / Q000150:complications / Q000188:drug therapy
chemical_list: D000666:Amphotericin B; D016178:Granulocyte-Macrophage Colony-Stimulating Factor