Signal transduction through the T-cell antigen receptor.
The mechanism by which ligand binding to the T-cell antigen receptor triggers the T-cell activation program has long been one of the most fascinating questions in lymphocyte biology. Here, we review recent insights into the transmembrane signaling functions of this multisubunit receptor complex.
Abraham
R T
RT
Department of Immunology, Mayo Clinic, Rochester, MN 55905.
Karnitz
L M
LM
Secrist
J P
JP
Leibson
P J
PJ
D000818:Animals; D006801:Humans; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D011948:Receptors, Antigen, T-Cell / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013601:T-Lymphocytes / Q000502:physiology
D011948:Receptors, Antigen, T-Cell; D011505:Protein-Tyrosine Kinases