[Effects of trimebutine on colonic propulsion in mice].
Effects of oral administration of trimebutine on colonic propulsion in conscious mice were studied by measuring the time required to evacuate a bead which had been inserted into the colon, and compared with those of metoclopramide and domperidone. In normal animals, trimebutine (10 and 50 mg/kg), metoclopramide (50 mg/kg) and domperidone (50 mg/kg) had no effect on the bead evacuation. Metoclopramide and domperidone at 30 mg/kg showed no effect on the delay of colonic propulsion induced by clonidine, while trimebutine (10 and 30 mg/kg) restored the delay significantly. Trimebutine also showed restoration of the delay induced by loperamide. On the acceleration of the propulsion induced by neostigmine, trimebutine (10 and 30 mg/kg) showed an inhibition. In addition, trimebutine (3-30 mg/kg) dose-dependently suppressed the development of soft feces and/or diarrhea induced by neostigmine. According to the results, it is concluded that trimebutine produces both acceleration and inhibition on the colonic propulsion in mice.
Yamada
K
K
Pharmacological Research Laboratory, Tanabe Seiyaku Co., Ltd.
Onoda
Y
Y
D000284:Administration, Oral; D000818:Animals; D000930:Antidiarrheals; D003106:Colon / Q000187:drug effects* / Q000502:physiology; D004294:Domperidone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005769:Gastrointestinal Motility / Q000187:drug effects*; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology; D051379:Mice; D009388:Neostigmine / Q000037:antagonists & inhibitors; D014287:Trimebutine / Q000008:administration & dosage / Q000494:pharmacology*
D000930:Antidiarrheals; D009388:Neostigmine; D004294:Domperidone; D008787:Metoclopramide; D014287:Trimebutine