[Characteristics of pharmacokinetics of liposome-incorporated rifampicin in rats after intratracheal administration].
Pharmacokinetics of rifampicin after its single intratracheal administration in the form of the liposome-encapsulated drug and its aqueous solution was studied on rats. It was shown that after the exposure to the liposome-incorporated rifampicin (10 mg/kg) the concentration-time curve in the blood and lungs was sigmoid with the retarded decrease in the blood drug concentration within 9 hours. The plateau segment of the curve provided at least a 4-fold longer maintenance of the rifampicin concentration in the blood and lungs at 3 to 4 micrograms/ml. The use of the liposome-incorporated antibiotic induced 2- and 1.5-fold increases in the AUC in regard to the lungs and blood, respectively.
Gurevich
G L
GL
Berezovskaia
L N
LN
Manuĭlov
K K
KK
D000818:Animals; D002406:Catheterization, Peripheral; D004337:Drug Carriers; D008081:Liposomes; D008099:Liver / Q000378:metabolism*; D008168:Lung / Q000378:metabolism*; D008954:Models, Biological; D051381:Rats; D012293:Rifampin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors; D014132:Trachea / Q000187:drug effects
D004337:Drug Carriers; D008081:Liposomes; C032393:25-deacetylrifampicin; D012293:Rifampin
Osobennosti farmakokinetiki rifampitsina, vkliuchennogo v liposomy, u krys pri vnutritrakheal'nom vvedenii.