title: The second and third model of the flow transformed pulsatile total artificial heart.
abstract: For the purpose of future total implantation, a new pulsatile total artificial heart, a flow transformed pulsatile total artificial heart (FTPTAH), in which the continuous flow from a single centrifugal pump (CFP) was converted to pulsatile flow by switching two three-way valves that could alternately perfuse the systemic and pulmonary circulation, was proposed, and the data from the prototype model were reported. As the next step, the second model, in which a CFP and a spool valve (SV) driven with a solenoid were fabricated in one piece, was made and tested in a mock circulatory system. The system could send 4.7 L/min of pulsatile output alternately to the pulmonary artery and aorta, with 30 and 100 mmHg afterload, respectively, at 3000 rpm CFP. However, three problems were encountered: the output was not enough, mixture or inversion of venous and arterial blood in the CFP would occur, and heat generation at the solenoid was very severe. To solve these problems, a third model was designed in the current study. To increase pump output, hydrodynamic analysis was performed. The SV was divided into inlet and outlet to control the blood mixture or inversion. To suppress heat generation, each SV was driven back and forth by two solenoids, one on each side of the SV. The model revealed satisfactory results in a mock circulatory system.
authors.affiliation: Institute of Medical Electronics, Faculty of Medicine, University of Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Imachi
authors.forename: T
authors.initials: T
authors.lastname: Isoyama
authors.forename: T
authors.initials: T
authors.lastname: Chinzei
authors.forename: Y
authors.initials: Y
authors.lastname: Abe
authors.forename: K
authors.initials: K
authors.lastname: Mabuchi
authors.forename: T
authors.initials: T
authors.lastname: Yonezawa
authors.forename: K
authors.initials: K
authors.lastname: Imanishi
authors.forename: A
authors.initials: A
authors.lastname: Kouno
authors.forename: T
authors.initials: T
authors.lastname: Ono
authors.forename: A
authors.initials: A
authors.lastname: Suzuki
mesh_terms: D001698:Biomedical Engineering; D006354:Heart, Artificial; D006439:Hemodynamics; D006358:Hot Temperature; D006801:Humans; D066298:In Vitro Techniques; D011474:Prosthesis Design; D011673:Pulsatile Flow