title: [Brain mapping for discriminating age related changes from dementia].
abstract: BM-EEG (Brain Mapping) and BM-P300 was studied for age related changes in 63 healthy controls (17.1-87.9 years). Additionally the discriminative power of both functional measures was tested in 21 patients with the clinical diagnosis (NINCDS-ADRDA) of probable dementia of Alzheimer type (DAT) of mild to moderate degree (Global Deterioration Scale, 4.2 +/- 2.6). For global and regional absolute and relative power values in the 4 frequency bands alpha, beta, theta and delta, the alpha-peak, P300 latency and amplitudes, quantitative and topographical aspects were analysed. Despite a broad variation of normal values both tests revealed age related changes. For separation between DAT and normal controls BM-EEG was superior to BM-P300. Relative global and regional theta power was the most sensitive parameter to discriminate both groups. BM data are compared with reported findings of traditional EEG and cognitive evoked potentials.
authors.affiliation: Neurologische Universitätsklinik Köln.
authors.forename: B
authors.initials: B
authors.lastname: Szelies
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000503:physiopathology; D001143:Arousal / Q000502:physiology*; D001288:Attention / Q000502:physiology*; D001931:Brain Mapping / Q000295:instrumentation*; D002540:Cerebral Cortex / Q000503:physiopathology; D004569:Electroencephalography / Q000295:instrumentation*; D005072:Evoked Potentials, Auditory / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011930:Reaction Time / Q000502:physiology; D012016:Reference Values; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*
vernacular_title: Brain mapping zur Darstellung altersabhängiger Veränderungen in Abgrenzung von Demenz.