title: Effects of peripheral hormones on memory and ingestive behaviors.
abstract: This article explores the mechanisms by which peripheral gastrointestinal hormones produce central nervous system effects on memory and feeding. Cholecystokinin produces its satiety effects and memory-enhancing effects by stimulating ascending vagal fibers. Hyperglycemia has been demonstrated to be a cause of memory dysfunction in persons with diabetes mellitus. A number of other hormones, such as amylin and bombesin, modulate both memory processing and feeding. The causes of the anorexia of aging are briefly reviewed.
authors.affiliation: Geriatric Research, Education, and Clinical Center, St. Louis Department of Veterans Affairs, Missouri.
authors.forename: J E
authors.initials: JE
authors.lastname: Morley
authors.forename: J
authors.initials: J
authors.lastname: Flood
authors.forename: A J
authors.initials: AJ
authors.lastname: Silver
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D000855:Anorexia / Q000503:physiopathology; D001066:Appetite / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000503:physiopathology*; D002766:Cholecystokinin / Q000502:physiology; D004435:Eating / Q000502:physiology*; D005768:Gastrointestinal Hormones / Q000502:physiology; D006728:Hormones / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000502:physiology; D008568:Memory / Q000502:physiology*; D009479:Neuropeptides / Q000502:physiology
chemical_list: D001786:Blood Glucose; D005768:Gastrointestinal Hormones; D006728:Hormones; D007328:Insulin; D009479:Neuropeptides; D002766:Cholecystokinin