title: Interleukin-6 in renal cell carcinoma.
abstract: We studied interleukin-6 production in 4 human renal cell carcinoma cell lines and measured the serum level in 71 patients with renal cell carcinoma, thus, clarifying a relationship between interleukin-6 secretion and an occurrence of the paraneoplastic syndrome in the carcinoma. Interleukin-6 was produced by 3 cell lines and detected in 25% of the patients. The level of interleukin-6 did not directly correlate with tumor volume and the differentiation grade of the carcinoma. However, the positive rate increased with progression of the stage. The serum level affected the 5-year survival of patients without distant metastasis. When serum interleukin-6 was elevated patients had a significantly higher frequency of unexplained fever and an elevation of acute phase proteins. These results suggest that some renal cell carcinomas can produce interleukin-6 and this cytokine is responsible for several paraneoplastic syndromes in the carcinoma.
authors.affiliation: Department of Urology, Sapporo Medical College, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tsukamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Kumamoto
authors.forename: N
authors.initials: N
authors.lastname: Miyao
authors.forename: N
authors.initials: N
authors.lastname: Masumori
authors.forename: A
authors.initials: A
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Yanase
mesh_terms: D002292:Carcinoma, Renal Cell / Q000097:blood / Q000378:metabolism*; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D007680:Kidney Neoplasms / Q000097:blood / Q000378:metabolism*; D014407:Tumor Cells, Cultured
chemical_list: D015850:Interleukin-6