title: [A study of urinary tegafur, 5-fluorouracil (5-FU) and uracil concentrations in the cases of gastric carcinoma for the confirmation of drug-taking compliance after UFT oral administration].
abstract: We have measured urinary tegafur (FT), 5-FU and uracil concentrations after UFT oral administration (300 mg daily for 7 days) to confirm drug-taking compliance in the 17 cases undergone gastrectomy. Urinary FT and 5-FU concentrations reached to the plateau 2 and 3 days after administration, respectively, and were maintained until the day after termination of administration. Subsequently, FT and 5-FU concentrations also decreased about 50% at 2 day, 20% at 3 day, 10% of the plateau values at 4 day after termination, respectively. The mean plateau value of urinary FT was 12.9 +/- 6.8 micrograms/dl, and that of urinary 5-FU was 0.67 +/- 0.50 microgram/dl. On the other hand, uracil concentration, was not different before and after administration because of the uracil being present endogenously. Therefore, it was suggested that measurement of urinary FT and 5-FU concentrations is useful for confirmation of UFT-taking compliance.
authors.affiliation: First Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ohsawa
authors.forename: Y
authors.initials: Y
authors.lastname: Kondo
authors.forename: H
authors.initials: H
authors.lastname: Shiroto
authors.forename: H
authors.initials: H
authors.lastname: Masuko
authors.forename: T
authors.initials: T
authors.lastname: Fukushima
authors.forename: A
authors.initials: A
authors.lastname: Kataoka
authors.forename: K
authors.initials: K
authors.lastname: Ohmori
authors.forename: Y
authors.initials: Y
authors.lastname: Sawaguchi
authors.forename: E
authors.initials: E
authors.lastname: Baba
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D000284:Administration, Oral; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000493:pharmacokinetics; D017024:Chemotherapy, Adjuvant; D003187:Compliance; D005472:Fluorouracil / Q000652:urine*; D005743:Gastrectomy; D006801:Humans; D011184:Postoperative Period; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000652:urine*; D005641:Tegafur / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000652:urine*; D014498:Uracil / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000652:urine*
chemical_list: D005641:Tegafur; D014498:Uracil; D005472:Fluorouracil