Potentiation of hypoglycemic response of glibenclamide by piroxicam in rats and humans.
Influence of piroxicam (PX) on glibenclamide (GL) induced hypoglycemia has been studied in rats, healthy human volunteers and diabetics. GL per se has significantly reduced blood sugar levels in rats and in humans. PX per se has significantly reduced BSLs, in diabetics, while having no significant influence on blood sugar level in rats and healthy human volunteers. Prior administration of PX has potentiated the hypoglycemic effect of GL in rats, healthy human volunteers and diabetics. GL, PX + GL administration have also significantly influenced the glucose tolerance test (GTT) in healthy human volunteers.
Diwan
P V
PV
Pharmacology Group, Indian Institute of Chemical Technology, Hyderabad.
Sastry
M S
MS
Satyanarayana
N V
NV
D000818:Animals; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy; D004347:Drug Interactions; D005260:Female; D005905:Glyburide / Q000627:therapeutic use; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced; D008297:Male; D010894:Piroxicam / Q000494:pharmacology*; D051381:Rats
D001786:Blood Glucose; D010894:Piroxicam; D005905:Glyburide