Toxic effects of different concentrations of dimethoate on lysosomal enzymes of female albino rats.
The effect of three different concentrations of dimethoate on the activity of certain lysosomal enzymes, viz. beta-glucuronidase, beta-N-acetylglucosaminidase, cathepsin B and cathepsin D in serum, skin, liver, kidney and spleen and the stability of liver and kidney lysosomes was studied in female albino rats. The activity of beta-glucuronidase, beta-N-acetylglucosaminidase, cathepsin D was found to increase in serum and tissues in higher concentration (2.25 mg/100 g body weight) of dimethoate treated rats. A significant increase in the rate of release of beta-glucuronidase was found in the liver and kidney of higher concentration of dimethoate treated rats compared to controls. The results demonstrate that the activity of lysosomal enzymes increased in higher concentration of dimethoate treated rats than the lower concentration (0.56 mg/100 g body weight) of dimethoate treated rats.
Reddy
P N
PN
Biochemistry Laboratory, Central Leather Research Institute, Madras, India.
Raj
G D
GD
Dhar
S C
SC
D000818:Animals; D004117:Dimethoate / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar / Q000378:metabolism; D012867:Skin / Q000201:enzymology; D014781:Viscera / Q000201:enzymology
D004117:Dimethoate