Does a HDL injection reduce the development of serum hyperlipidemia and progression of fatty streaks in cholesterol fed rabbits?
The influences of homologous (rabbit) or heterologous (human) high density lipoprotein (HDL) on the development of serum hyperlipidemia and progression of fatty streaks were studied in cholesterol fed rabbits. Three groups of New Zealand rabbits were fed a 0.5% cholesterol rich diet for 8 weeks. Additionally into these animals the following solutions were injected intravenously two times per week: group 1 (control): saline; group 2: human HDL dissolved in saline; group 3: rabbit HDL dissolved in saline. The animals of group 2 had lower serum cholesterol levels during the dietary period than rabbits of group 1 (p < 0.05) but the surface of intima covered with fatty streaks was the same as in group 1. On the other hand, the serum cholesterol level in rabbits of group 3 was the same as in group 1 during the whole experimental period, but the surface of aorta covered with fatty streaks was significantly lower (p < 0.05) in group 3 than in group 1. The results of this study support the hypothesis of an antiatherogenic action of HDL, which seems to be independent of the influence of HDL on the serum lipids but depends on the source of HDL.
Beitz
J
J
Martin Luther University Halle-Wittenberg, Department of Pharmacology and Toxicology, Germany.
Beitz
A
A
Antonov
I V
IV
Misharin
A Y
AY
Mest
H J
HJ
D000818:Animals; D001161:Arteriosclerosis / Q000139:chemically induced / Q000517:prevention & control*; D002791:Cholesterol, Dietary / Q000009:adverse effects*; D004036:Diet, Atherogenic; D006801:Humans; D006949:Hyperlipidemias / Q000139:chemically induced / Q000517:prevention & control*; D007275:Injections, Intravenous; D008075:Lipoproteins, HDL / Q000008:administration & dosage / Q000627:therapeutic use*; D011817:Rabbits; D013045:Species Specificity
D002791:Cholesterol, Dietary; D008075:Lipoproteins, HDL