Bacteriophage lambda PaPa: not the mother of all lambda phages.
The common laboratory strain of bacteriophage lambda--lambda wild type or lambda PaPa--carries a frameshift mutation relative to Ur-lambda, the original isolate. The Ur-lambda virions have thin, jointed tail fibers that are absent from lambda wild type. Two novel proteins of Ur-lambda constitute the fibers: the product of stf, the gene that is disrupted in lambda wild type by the frameshift mutation, and the product of gene tfa, a protein that is implicated in facilitating tail fiber assembly. Relative to lambda wild type, Ur-lambda has expanded receptor specificity and adsorbs to Escherichia coli cells more rapidly.
Hendrix
R W
RW
Department of Biological Sciences, University of Pittsburgh, PA 15260.
Duda
R L
RL
D000327:Adsorption; D000595:Amino Acid Sequence; D010582:Bacteriophage lambda / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D002874:Chromosome Mapping; D004926:Escherichia coli / Q000235:genetics / Q000502:physiology / Q000528:radiation effects; D016368:Frameshift Mutation; D005814:Genes, Viral; D008854:Microscopy, Electron; D008969:Molecular Sequence Data; D008970:Molecular Weight; D014466:Ultraviolet Rays; D017376:Viral Tail Proteins / Q000737:chemistry / Q000235:genetics*
D017376:Viral Tail Proteins