[Protective action of 21-aminosteroids in post-ischemic shock (splanchnic artery occlusion). Experimental model].
In anesthetized Wistar female rats a post-ischemic shock have been induced by splanchnic artery occlusion (S.A.O.). In these condition all animals died at 90 min., past release of occlusion and splanchnic reperfusion. 100% of pretreated rats with 21-Aminosteroids (U74389F) at doses of 1.5 mg.kg-1 survive over 3-6 hours, and 50% over 12 hours. Moreover, TNF alpha in these animals decrease significantly (p < 0.05). These results shown that 21-Aminosteroids can cause protective activity on lipoperoxidative damage in post-ischemic shock.
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Istituto di Anestesia e Rianimazione, Università di Palermo.
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D'Alessandro
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D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001158:Arteries; D005260:Female; D011281:Pregnatrienes / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012769:Shock / Q000097:blood / Q000188:drug therapy* / Q000401:mortality; D013152:Splanchnic Circulation; D015996:Survival Rate; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D000975:Antioxidants; D011281:Pregnatrienes; D014409:Tumor Necrosis Factor-alpha; C074965:U 74389F
Attività protettiva dei 21-aminosteroidi nello shock post-ischemico (S.A.O.). Modello sperimentale.