title: Spontaneous chylothorax in Noonan syndrome. Treatment with prednisone.
abstract: OBJECTIVE
  To describe a case of spontaneous chylothorax in a child with Noonan syndrome successfully treated with prednisone.
  
  
  METHODS
  Case report.
  
  
  METHODS
  A pediatric cardiology referral center for the Rocky Mountain region.
  
  
  METHODS
  An 18-month-old girl with Noonan's syndrome, pulmonary stenosis, and hypertrophic cardiomyopathy who presented with spontaneous chylothorax.
  
  
  METHODS
  The child's chylothorax did not respond to thoracic duct ligation, tetracycline pleurodesis, and pleurectomy during a 2-month period. A low-fat diet was helpful but did not eliminate the problem. Prednisone was started orally at 1 mg/kg per dose twice daily and slowly tapered during 3 months. The chylothorax did not recur during 8 months of follow-up.
  
  
  CONCLUSIONS
  Prednisone may be useful in the treatment of chylothorax in Noonan syndrome. A controlled clinical trial would be helpful but would be difficult in such a rare complication of an uncommon syndrome.
authors.affiliation: University of Colorado School of Medicine, Denver Children's Hospital.
authors.forename: M B
authors.initials: MB
authors.lastname: Goens
authors.forename: D
authors.initials: D
authors.lastname: Campbell
authors.forename: J W
authors.initials: JW
authors.lastname: Wiggins
mesh_terms: D002916:Chylothorax / Q000000981:diagnostic imaging / Q000628:therapy*; D004322:Drainage; D005260:Female; D006801:Humans; D007223:Infant; D009634:Noonan Syndrome / Q000150:complications*; D011241:Prednisone / Q000627:therapeutic use*; D011859:Radiography
chemical_list: D011241:Prednisone