[Effects of insulin on expression of oncogenes in CWE mouse brain].
By RNA dot blot hybridization, we observed the expression of c-myc, c-fos, Ha-ras and erbB genes in normal brain of CWE mouse after the injection of insulin. Transcription of the c-myc and c-fos genes is greatly increased, which peaks approximately 2 h after insulin stimulation, decreases in 6 h and returns to the initial levels within 48 h. The alteration in Ha-ras transcription appears more complex; its expression decreases first but increases subsequently. We also detected the expression of erbB gene which decreases after the injection of insulin. The results suggest that c-myc, c-fos, Ha-ras and erbB might be directly involved in growth control. Their protein products might play a role in intracellular signal transduction.
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D000818:Animals; D015152:Blotting, Northern; D001921:Brain / Q000166:cytology / Q000187:drug effects*; D015870:Gene Expression / Q000187:drug effects*; D016762:Genes, fos / Q000235:genetics; D016259:Genes, myc / Q000235:genetics; D011905:Genes, ras / Q000235:genetics; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009857:Oncogenes / Q000235:genetics*
D007328:Insulin