[Change in the intensity of biosynthesis of proteins, lipids and glycogen in animal tissues during long-term administration of morphine].
The intensity of biosynthesis processes in animal organism has been studied as affected by long-term administration of morphine. It was established that morphine administration to rats for five weeks intensified protein biosynthesis in the brain, kidneys, skeletal muscles: specific radioactivity of blood serum proteins also increased. Incorporation of 2-/14C/glycine label to the brain, cardiac and skeletal muscles increased as affected by morphine: the label incorporation to the liver lipids decreased and that to the kidney and spleen lipids did not change. Specific radioactivity of glycogen multiply increased in the rat liver as affected by morphine.
Sushkova
V V
VV
Stogniĭ
N A
NA
Kas'ianova
N N
NN
Shevtsova
N F
NF
Gulyĭ
M F
MF
D000818:Animals; D001798:Blood Proteins / Q000187:drug effects / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D006003:Glycogen / Q000096:biosynthesis*; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009020:Morphine / Q000008:administration & dosage*; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D014176:Protein Biosynthesis; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors
D001798:Blood Proteins; D008055:Lipids; D009020:Morphine; D006003:Glycogen
Izmenenie intensivnosti biosinteza belkov, lipidov i glikogena v tkaniakh zhivotnykh pri dlitel'nom vvedenii morfina.