[Effects of anisodamine and atropine on the microvasculature of liver, skeletal muscle and foot-pad skin in anesthetized rats].
Rats were urethanised and kept in a constant temperature chamber. The surface temperature of various organs including the liver and the armpit skeletal muscle were monitored with a special mercury thermometer through a narrow hole on the skin cut with scalpel. The temperature of the foot-pad skin were measured using a thermometer as reported previously. After iv of anisodamine or atropine at doses of 12.5-50 micrograms/kg the temperature of the liver and the armpit skeletal muscle were significantly reduced in a dose-dependent manner but the skin temperature was increased. Temperature changes were observed 5 min after drug administration, reaching peak height at about 15 min and maintained for one hour or so. Isoprenaline, dopamine and aminophylline iv showed only a temperature-elevating effect, while serotonin and noradrenaline caused only a temperature-decreasing effect in all the three organs mentioned above. Although the functional significance of the opposite effects on the microcirculation of different tissues remain to be defined, the effects of atropine-like drugs must result in a redistribution of circulating blood and may have beneficial effects on the survival of some vital organs such as brain, lungs, kidneys ... especially in shock.
Wang
W C
WC
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
Lee
Y N
YN
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects; D008099:Liver / Q000098:blood supply* / Q000502:physiology; D008833:Microcirculation / Q000187:drug effects; D009132:Muscles / Q000098:blood supply* / Q000502:physiology; D051381:Rats; D012867:Skin / Q000098:blood supply*; D012881:Skin Temperature / Q000187:drug effects; D012991:Solanaceous Alkaloids / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology*
D012991:Solanaceous Alkaloids; D014665:Vasodilator Agents; C003922:anisodamine; D001285:Atropine