title: Effects of macrolide antibiotics on gastrointestinal motility in fasting and digestive states.
abstract: The effect of macrolide antibiotics on gastrointestinal motility was studied in unanaesthetized dogs by using strain-gauge transducers. Midecamycin acetate, leucomycin, josamycin and acetylspiramycin, which are 16-membered macrolides, did not affect the gastrointestinal motility and no symptoms of gastrointestinal disorder were observed. On the other hand, erythromycin, roxithromycin, clarithromycin and oleandomycin, which are 14-membered macrolides, caused giant contraction and disorder symptoms. Moreover, it was found that the glycosidic linkages of the lactone ring were necessary for a structure to exert strong contractile activity.
authors.affiliation: Pharmaceutical Research Centre, Meiji Seika Kaisha, Ltd., Yokohama, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakayoshi
authors.forename: M
authors.initials: M
authors.lastname: Izumi
authors.forename: K
authors.initials: K
authors.lastname: Tatsuta
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004063:Digestion / Q000502:physiology*; D004064:Digestive System / Q000187:drug effects; D004068:Digestive System Physiological Phenomena; D004285:Dogs; D004594:Electrophysiology; D005215:Fasting / Q000502:physiology*; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D018942:Macrolides; D009119:Muscle Contraction / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides