Mechanoluminescence: an assay for lymphocyte analysis in neoplasia.
We have studied the mechano-electrochemical activation of optical emission (mechanoluminescence, ML) from the surface of lymphocytes. In C57BL/6 mice with B16 melanoma at the terminal stage of tumour growth and after immunotherapy with thymic agents, there is a correlation between light emission and the value of lymphocyte surface charge and titres of thymic serum factor (FTS).
Orel
V E
VE
Physics-technical Laboratory, Kiev Research Institute of Oncology, Ukraine.
Alekseyev
S B
SB
Grinevich
Y A
YA
D000328:Adult; D000818:Animals; D000954:Antigens, Surface / Q000032:analysis*; D006801:Humans; D007167:Immunotherapy; D008163:Luminescent Measurements; D008175:Lung Neoplasms / Q000276:immunology* / Q000556:secondary; D008214:Lymphocytes / Q000276:immunology* / Q000473:pathology; D008297:Male; D008546:Melanoma, Experimental / Q000276:immunology* / Q000628:therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D008875:Middle Aged; D012016:Reference Values; D013601:T-Lymphocytes / Q000276:immunology; D013935:Thymic Factor, Circulating / Q000032:analysis; D014397:Tuberculosis, Pulmonary / Q000276:immunology*
D000954:Antigens, Surface; D013935:Thymic Factor, Circulating