title: [Intrathecal morphine for postoperative pain relief after transvaginal hysterectomy].
abstract: We studied the effect of a low-dose intrathecal morphine (0.1 or 0.2 mg) in postoperative pain relief and the incidence of side effects. Two hundred and fifteen patients scheduled for transvaginal hysterectomy were divided into 3 groups according to intrathecal morphine doses: M1 (morphine 0.1 mg N = 75), M2 (morphine 0.2 mg N = 69) and C (control N = 71). A standard mid-line lumbar puncture was performed using a 25-gauze needle in the L3/4 interspace. Preservative-free morphine hydrochloride mixed in hyperbaric tetracaine solution was administered intrathecally. Pain relief was significantly greater for the first 24 hrs in groups M1 and M2 compared with group C. Respiratory depression was not seen in any groups. The incidence of vomiting was about 40% in all groups. We conclude that intrathecal morphine 0.1-0.2 mg is useful for pain relief after transvaginal hysterectomy and accompanies no major side effects.
authors.affiliation: Department of Anesthesia, Kitami Red Cross Hospital.
authors.forename: O
authors.initials: O
authors.lastname: Satoh
authors.forename: Y
authors.initials: Y
authors.lastname: Hatakeyama
authors.forename: F
authors.initials: F
authors.lastname: Miyazawa
authors.forename: T
authors.initials: T
authors.lastname: Tsumura
authors.forename: M
authors.initials: M
authors.lastname: Miyabe
authors.forename: A
authors.initials: A
authors.lastname: Namiki
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007278:Injections, Spinal; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage* / Q000009:adverse effects; D010149:Postoperative Pain / Q000188:drug therapy*; D014839:Vomiting / Q000139:chemically induced
chemical_list: D009020:Morphine