Adhesion molecules in antibacterial defenses: effects of bacterial extracts.
Adhesion of polymorphonuclear leukocytes (PMN) to vascular endothelium is one of the first events in their response against local bacterial infection. Different adhesion molecules sequentially mediate PMN adherence to endothelium and extravasation into inflamed tissues. We show that bacterial extracts OM-85 BV and OM-89 increase the expression of adhesion molecules at the surface of PMN and we suggest that this upregulation could be linked to the beneficial effect of bacterial extracts in the prevention of respiratory tract infections.
Marchant
A
A
Department of Immunology, Hôpital Erasme, Université Libre de Bruxelles, Belgium.
Duchow
J
J
Goldman
M
M
D006801:Humans; D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000942:Antigens, Bacterial; D001419:Bacteria / Q000276:immunology; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000276:immunology / Q000378:metabolism; D004730:Endothelium, Vascular / Q000502:physiology; D016023:Integrins / Q000378:metabolism; D009504:Neutrophils / Q000378:metabolism / Q000502:physiology; D000095983:Bacterial Lysates
D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial; D015815:Cell Adhesion Molecules; D016023:Integrins; C030259:Broncho-Vaxom; D000095983:Bacterial Lysates; C050501:OM 89