A case of Raynaud's disease with uterine cancer producing interleukin-6.
A case of cervical cancer of the uterine producing interleukin-6(IL-6) in a patient who suffered from Raynaud's phenomenon is described. Her serum contained anti SS-A antibody. The cancer was removed surgically. High level of IL-6 activity was detected in the culture supernatant of the resected cancer cells. After operation, Raynaud's phenomenon had improved and anti SS-A antibody had disappeared. This case shows us that IL-6 produced by malignant tumour might induce autoimmune connective tissue disease-like symptoms.
Murashima
A
A
Department of Internal Medicine, Juntendo University, School of Medicine, Tokyo, Japan.
Takasaki
Y
Y
Hashimoto
H
H
Hirano
T
T
Hirose
S
S
D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D011928:Raynaud Disease / Q000097:blood / Q000150:complications* / Q000378:metabolism*; D014594:Uterine Neoplasms / Q000097:blood / Q000150:complications* / Q000378:metabolism*
D000974:Antibodies, Antinuclear; D015850:Interleukin-6; C035356:SS-A antibodies