title: Trans-activation by hepatitis B virus X protein is mediated via a tumour promoter pathway.
abstract: We have studied the c-myc gene as a possible target of HBV X protein in liver carcinogenesis. Our results indicate that trans-activation by X protein occurs via PKC/AP1 signal transduction, suggesting a possible two-step mechanism in HBV related liver carcinogenesis.
authors.affiliation: Max-Planck-Institut für Biochemie, Martinsried, Federal Republic of Germany.
authors.forename: A S
authors.initials: AS
authors.lastname: Kekulé
authors.forename: U
authors.initials: U
authors.lastname: Lauer
authors.forename: L
authors.initials: L
authors.lastname: Weiss
authors.forename: P H
authors.initials: PH
authors.lastname: Hofschneider
authors.forename: R
authors.initials: R
authors.lastname: Koshy
mesh_terms: D002478:Cells, Cultured; D016259:Genes, myc / Q000235:genetics; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology; D011493:Protein Kinase C / Q000378:metabolism; D015398:Signal Transduction; D015534:Trans-Activators / Q000235:genetics*; D015533:Transcriptional Activation; D054334:Viral Regulatory and Accessory Proteins
chemical_list: D015534:Trans-Activators; D054334:Viral Regulatory and Accessory Proteins; C057628:hepatitis B virus X protein; D011493:Protein Kinase C