Central nervous system systemic lupus erythematosus mimicking progressive multifocal leucoencephalopathy.
The case is reported of a patient with central nervous system systemic lupus erythematosus (SLE) with features of progressive multifocal leucoencephalopathy (PML) seen clinically and by magnetic resonance imaging. A brain biopsy sample showed microinfarcts. The use of magnetic resonance imaging and IgG synthesis rates in evaluating central nervous system lupus, the co-occurrence of SLE and PML, and the differentiation of these entities by magnetic resonance imaging and by histology are considered.
Kaye
B R
BR
East Bay Rheumatology Medical Group, Oakland, CA.
Neuwelt
C M
CM
London
S S
SS
DeArmond
S J
SJ
D000328:Adult; D001707:Biopsy, Needle; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000473:pathology*; D008180:Lupus Erythematosus, Systemic / Q000473:pathology*; D008279:Magnetic Resonance Imaging