Gluconeogenesis from methylglyoxal in isolated murine hepatocytes. Does an alternative pathway exist in which pyruvate is not an intermediate?
1. Gluconeogenesis from alanine can be prevented by the addition of monoiodo acetic acid (an inhibitor of glyceraldehyde 3-phosphate dehydrogenase), while glucose production from methylglyoxal is only partially inhibited by this compound. 2. It is supposed that methylglyoxal can enter gluconeogenic sequence not only at pyruvate.
Riba
P
P
Semmelweis University, Medical School, First Institute of Biochemistry, Budapest, Hungary.
Garzó
T
T
Mandl
J
J
Kalapos
M P
MP
D000818:Animals; D002478:Cells, Cultured; D005943:Gluconeogenesis; D008099:Liver / Q000378:metabolism*; D051379:Mice; D011765:Pyruvaldehyde / Q000378:metabolism*; D011773:Pyruvates / Q000378:metabolism
D011773:Pyruvates; D011765:Pyruvaldehyde