[Experimental evaluation of the allergen activity of a peptide preparation produced from an enzymatic hydrolysate of milk proteins using ultrafiltration].
Noninbred guinea-pig experiments were performed to investigate specific potential allergenicity of cow milk proteins (CMP) consisting of casein (80%) and serum proteins (20%), of low-molecular peptides (LMP 20/80) produced from CMP 20/80 by enzymatic hydrolysis and ultrafiltration; to evaluate nonspecific effect of test diet CMP 20/80 and LMP 20/80 on anaphylactic response of the animals to ovalbumin and histamine LD50. LMP 20/80 versus CMP 20/80 had a hypoallergenic effect. Potential mechanisms of low anaphylactic sensitivity induced by LMP 20/80 are discussed.
Malikova
N A
NA
Krzhechkovskaia
V V
VV
Kruglik
V I
VI
Mazo
V K
VK
D000485:Allergens; D000818:Animals; D006168:Guinea Pigs; D006868:Hydrolysis; D008894:Milk Proteins; D008970:Molecular Weight; D010455:Peptides; D014462:Ultrafiltration
D000485:Allergens; D008894:Milk Proteins; D010455:Peptides
Eksperimental'naia otsenka allergennogo deĭstviia peptidnogo preparata, poluchennogo iz fermentativnogo gidrolizata belkov moloka s ispol'zovaniem ul'trafil'tratsii.