title: [The effect of a different energy supply on the growth intensity and skeletal development of growing Great Danes. 2. Effect on insulin-like growth factor I and on thyroid hormones].
abstract: In an experiment with 13 growing Great Danes (littermates) fed ad libitum (4 dogs) or restrictively (70% of ad libitum energy intake; 9 dogs), concentrations of insulin-like growth factor I (IGF-I), 3,5,3'-triiodothyronine (T3) and thyroxine (T4) were measured in blood samples until the age of 6 months. In the ad libitum fed group, levels of T3 and T4 were partially and of IGF-I were significantly (p < 0.01) elevated as compared with the control dogs. Postprandial changes of IGF-I were absent in growing Great Danes as well as in a reference group of 3 adult beagles. Increased concentrations of IGF-I, T3 and T4 could be causally related to osteochondrosis, which frequently occurs in intensively fed dogs.
authors.affiliation: Institut für Tierernährung Tierärztlichen Hochschule Hannover, Germany.
authors.forename: J W
authors.initials: JW
authors.lastname: Blum
authors.forename: J
authors.initials: J
authors.lastname: Zentek
authors.forename: H
authors.initials: H
authors.lastname: Meyer
mesh_terms: D000821:Animal Feed; D000818:Animals; D001846:Bone Development; D001947:Breeding; D004285:Dogs / Q000254:growth & development*; D002149:Energy Intake / Q000502:physiology*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D013963:Thyroid Hormones / Q000097:blood*
chemical_list: D013963:Thyroid Hormones; D007334:Insulin-Like Growth Factor I
vernacular_title: Untersuchungen zum Einfluss einer unterschiedlichen Energieversorgung auf die Wachstumsintensität und Skelettenwicklung bei wachsenden Doggen. 2. Mitteilung: Einfluss auf den insulinähnlichen Wachstumsfaktor I und auf Schilddrüsenhormone.