title: Effect of five-membered heterocycles against Leishmania donovani infection.
abstract: Impact of change of heteroatom in pentavalent heterocycles, viz., pyrroles, isoxazoles, imidazoles and crotonates on the profile of antileishmanial activity against amastigotes of L. donovani using in vivo test system and macrophage-amastigote culture system has been studied. Sixty-three compounds were tested. Nine imidazoles showed marginal activity in vivo, whereas 3 out of 10 compounds of isoxazolone series and 2 out of 4 substituted aminocrotonates exhibited antileishmanial activity. Of the 30 substituted pyrroles, except 8 all showed antileishmanial activity in vivo on day 7 post treatment.
authors.affiliation: Division of Parasitology, Central Drug Research Institute, Lucknow, India.
authors.forename: S
authors.initials: S
authors.lastname: Bhatnagar
authors.forename: V
authors.initials: V
authors.lastname: Nigam
authors.forename: P Y
authors.initials: PY
authors.lastname: Guru
authors.forename: J C
authors.initials: JC
authors.lastname: Katiyar
authors.forename: A
authors.initials: A
authors.lastname: Mukherjee
authors.forename: R C
authors.initials: RC
authors.lastname: Gupta
authors.forename: S
authors.initials: S
authors.lastname: Batra
authors.forename: M
authors.initials: M
authors.lastname: Seth
authors.forename: A P
authors.initials: AP
authors.lastname: Bhaduri
mesh_terms: D000818:Animals; D006224:Cricetinae; D006571:Heterocyclic Compounds / Q000627:therapeutic use*; D007898:Leishmaniasis, Visceral / Q000188:drug therapy*; D008297:Male
chemical_list: D006571:Heterocyclic Compounds