Bactericidal activity of ramoplanin against antibiotic-resistant enterococci.
Ramoplanin, a new lipoglycodepsipeptide antibiotic, was uniformly active against 65 strains of enterococci, including strains highly resistant to vancomycin, penicillin G, and gentamicin. MBCs were usually within a fourfold dilution of the MICs. In time-kill studies, ramoplanin alone demonstrated dose-dependent bactericidal activity against enterococcal strains that resisted killing by vancomycin or penicillin in combination with gentamicin.
Johnson
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CC
Medical College of Pennsylvania, Philadelphia 19129.
Taylor
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S
Pitsakis
P
P
May
P
P
Levison
M E
ME
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D047630:Depsipeptides; D004352:Drug Resistance, Microbial; D016983:Enterococcus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic
D000900:Anti-Bacterial Agents; D047630:Depsipeptides; D010456:Peptides, Cyclic; C041438:ramoplanin