Effect of the somatostatin analogue octreotide on gastric fluid pH in ponies.
The effect of the somatostatin analogue, octreotide, on gastric fluid pH was investigated in 4 ponies. Gastric fluid pH was determined after SC administration of octreotide or physiologic saline solution (control). A baseline sample of fluid was obtained, the agent was given, and 8 additional samples were collected hourly. Administration of octreotide at all dosages tested (0.1, 0.5, 1.0, and 5.0 micrograms/kg of body weight) increased gastric pH to > 5.0. Baseline values were consistently < 2.7. Administration of octreotide at these same dosages induced gastric pH values > 4.0 for 2.4 +/- 1.2, 4.8 +/- 0.8, 5.7 +/- 1.3, and 5.4 +/- 2.6 (mean +/- SD) continuous hours, respectively. Treatment at all dosages increased the pH of gastric fluid, compared with control values. The duration of the increase in pH was significantly (P < 0.05) different than that of the control treatment, even for the lowest dosage, 0.1 microgram/kg.
Sojka
J E
JE
Department of Veterinary Clinical Studies, Purdue University, West Lafayette, IN 47907.
Weiss
J S
JS
Samuels
M L
ML
You
G M
GM
D000818:Animals; D005260:Female; D005745:Gastric Acidity Determination / Q000662:veterinary; D005750:Gastric Juice / Q000187:drug effects*; D006736:Horses / Q000378:metabolism*; D015282:Octreotide / Q000494:pharmacology*
D015282:Octreotide