Immune pathogenesis of hepatitis A.
In an effort to elucidate the mechanism of liver damage resulting from Hepatitis A virus (HAV) infection, we have studied infected skin fibroblasts and autologous lymphocytes from HAV patients. We report here that HLA-restricted virus-specific T cells play an essential role in HAV-related hepatocellular injury.
Vallbracht
A
A
Abteilung Medizinische Virologie, Universität Tübingen, Federal Republic of Germany.
Fleischer
B
B
D005347:Fibroblasts / Q000276:immunology* / Q000382:microbiology; D006680:HLA Antigens / Q000276:immunology*; D006506:Hepatitis A / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology*; D012867:Skin / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology* / Q000382:microbiology
D006680:HLA Antigens