[Participation of protein C in reaction of the anti-coagulant system to intravenous administration of thrombin and thromboplastin to rats].
Dynamics of protein C concentration was studied in rat blood after administration of thrombin and thromboplastin. Administration of 0.5 ml 1% thromboplastin caused fast decrease of protein C concentration, down to 60% of the initial level, within 3 min, while activity of factor V reached the minimal rate (30%) within 5 min. Content of protein C returned to the initial level in blood within 2-2.5 hrs and of factor V--within 6 hrs. After administration of thrombin 3 NIH in content of protein C was decreased to 91.3% whereas heparin was released only after injection of 6 NIH. The data obtained suggest that the protein C system responded earlier to occurrence of thrombin in circulation as compared with the neurohumoral regulators of the anticoagulation system; the protein C system is one of primary mechanisms of the antithrombosis defence.
Kogan
A E
AE
Strukova
S M
SM
Tara
A A
AA
Aaviksaar
A A
AA
D000818:Animals; D001777:Blood Coagulation; D004211:Disseminated Intravascular Coagulation / Q000378:metabolism; D006487:Hemostasis; D007275:Injections, Intravenous; D011486:Protein C / Q000378:metabolism*; D051381:Rats; D013917:Thrombin / Q000008:administration & dosage*; D013925:Thromboplastin / Q000008:administration & dosage*
D011486:Protein C; D013925:Thromboplastin; D013917:Thrombin
Uchastie proteina C v reaktsii protivosvertyvaiushcheĭ sistemy na vnutrivennoe vvedenie krysam trombin i tromboplastina.