[The study of DNA ploidy as a prognostic factor in uterine cervical cancer].
Nuclear DNA content was measured in 410 paraffin-embedded samples from 136 cases (43 stage Ib and 93 stage IIb) of uterine cervical cancer by flow cytometry, and the significance of DNA ploidy for use as a prognostic factor was evaluated. Positive parametrial invasion cases (p less than 0.05), metastasis to pelvic lymph nodes cases and lymphatic vessel permeation form (p less than 0.05) showed a high incidence of DNA aneuploidy. In the study of the relationship between DNA ploidy and prognosis by the Kaplan-Meier method, the DNA aneuploid group showed a tendency to a poor prognosis in all cases, large cell non-keratinizing cases (p less than 0.05), and large cell non-keratinizing pT2b with pelvic lymph nodes metastasis cases (p less than 0.05), and the DNA aneuploid group had significantly lower three- and five-year survival rates (p less than 0.05).
Watanabe
Y
Y
Department of Obstetrics and Gynecology, Kinki University School of Medicine, Osaka.
Ikeda
M
M
D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D011003:Ploidies; D011379:Prognosis; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology
D004273:DNA, Neoplasm