13C and 1H NMR study of the metabolic degradation of 4-pentenoate in different dog nephron segments.
The metabolism of 4-pentenoate in isolated kidney tubules has been investigated by 1H and 13C NMR. The 4-pentenoate metabolite, 3-keto-4-pentenoyl-CoA, accumulated in proximal tubules only and its formation could be competitively inhibited by octanoate. 4-Pentenoate was metabolized in thick ascending limbs but not in papillary collecting ducts.
Boulanger
Y
Y
Département de Physiologie, Université de Montréal, Quebec, Canada.
Wong
H
H
Fleser
A
A
Commodari
F
F
Vinay
P
P
D000818:Animals; D002210:Caprylates / Q000494:pharmacology; D004285:Dogs; D005229:Fatty Acids, Monounsaturated / Q000378:metabolism*; D007684:Kidney Tubules / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy
D002210:Caprylates; D005229:Fatty Acids, Monounsaturated; C009785:4-pentenoic acid; C031492:octanoic acid