title: Depot leuprolide versus danazol in treatment of women with symptomatic endometriosis. I. Efficacy results.
abstract: OBJECTIVE
  We aimed to assess the efficacy of depot leuprolide versus danazol in the treatment of endometriosis.
  
  
  METHODS
  A double-blind randomized trial of 270 patients from 22 centers compared the pretreatment and posttreatment laparoscopic extent of endometriosis. Pretreatment and posttreatment endometriosis symptoms and signs were assessed with standardized methods.
  
  
  RESULTS
  When compared with danazol, leuprolide depot caused a more rapid and profound suppression of estradiol. Leuprolide depot and danazol were similarly efficacious in decreasing the extent of endometriosis, as well as the pain and tenderness associated with endometriosis.
  
  
  CONCLUSIONS
  Depot leuprolide is an effective alternative to danazol in decreasing the extent of endometriosis and endometriosis-related pain.
authors.affiliation: Center for Reproductive Medicine and Surgery, Baylor College of Medicine, Houston, Texas.
authors.forename: J M
authors.initials: JM
authors.lastname: Wheeler
authors.forename: J D
authors.initials: JD
authors.lastname: Knittle
authors.forename: J D
authors.initials: JD
authors.lastname: Miller
mesh_terms: D000293:Adolescent; D000328:Adult; D003613:Danazol / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D004715:Endometriosis / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D004958:Estradiol / Q000097:blood; D005260:Female; D005833:Genital Neoplasms, Female / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D010535:Laparoscopy; D016729:Leuprolide / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D003692:Delayed-Action Preparations; D004958:Estradiol; D016729:Leuprolide; D003613:Danazol