Age-related changes in cholinergic and noradrenergic transmission in the rat cerebellum. A histochemical and immunocytochemical study.
The histochemical and immunocytochemical distribution of some cholinergic and noradrenergic markers was compared in the cerebellum of young adult (3-month old) and aged (24-month old) Wistar rats. A decrease in the density and staining of acetyl cholinesterase (AChE) positive fibers, puncta and Golgi cells was found in both the cerebellar cortex and nuclei of aged rats. The age-related changes in choline acetyltransferase immunoreactivity were less pronounced than the changes in AChE activity. A reduction in the density of catecholamine fluorescent fibers and puncta was observed in the cerebellar cortex during aging. In aged rats the increase in monoamine oxidase (MAO)-A activity was more pronounced than the increase in MAO-B activity.
Lolova
I
I
Institute of Physiology Bulgarian Academy of Sciences, Sofia.
Davidoff
M
M
D000110:Acetylcholinesterase / Q000378:metabolism*; D000375:Aging / Q000502:physiology*; D000818:Animals; D015415:Biomarkers; D002395:Catecholamines / Q000378:metabolism*; D002531:Cerebellum / Q000166:cytology / Q000254:growth & development / Q000502:physiology*; D006651:Histocytochemistry; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000378:metabolism*; D008995:Monoamine Oxidase / Q000378:metabolism*; D009412:Nerve Fibers / Q000502:physiology / Q000648:ultrastructure; D011689:Purkinje Cells / Q000166:cytology / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
D015415:Biomarkers; D002395:Catecholamines; D007527:Isoenzymes; D008995:Monoamine Oxidase; D000110:Acetylcholinesterase