title: Influence of ovarian cysts on the results of in vitro fertilization.
abstract: OBJECTIVE
  To determine if ovarian cysts are associated with a particular basal endocrine profile and impair follicular growth.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  In Vitro Fertilization (IVF) Center.
  
  
  METHODS
  Nine hundred fourteen stimulation cycles stimulated with a combination of luteinizing hormone-releasing hormone analogues (LH-RH-a) and human menopausal gonadotropins (hMG) in a long protocol in an IVF program.
  
  
  RESULTS
  After 15 days of LH-RH-a therapy, ovarian cysts (> or = 20 mm) were observed in 8% of cases. These cysts were not related to a particular basal endocrine profile and did not impair follicular growth and IVF results. However, puncturing these cysts enhanced the quality of subsequent follicular growth. On the contrary, cysts appearing during hMG treatment (> or = 25 mm) were related with a lower LH:follicle-stimulating hormone ratio (0.79 +/- 0.52 versus 0.92 +/- 0.74 in absence of cyst) and to a lower ovarian response as assessed by the maximal estradiol level to the total number of hMG ampules ratio (51.6 +/- 36.5 versus 65.9 +/- 47.9 in absence of cyst). However, this difference had no influence on the pregnancy per stimulation rate (18% versus 16% in absence of cyst; not significant).
  
  
  CONCLUSIONS
  Results show that the pathogens of ovarian cysts appearing during the blockage phase and during the stimulation phase are different. However, they do not impair the results of IVF, and thus it is not necessary to cancel the attempt in case of ovarian cyst.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, Contrat Jeune Formation (INSERM CJF 89-08), Toulouse, France.
authors.forename: J
authors.initials: J
authors.lastname: Parinaud
authors.forename: K
authors.initials: K
authors.lastname: Cohen
authors.forename: P
authors.initials: P
authors.lastname: Oustry
authors.forename: M
authors.initials: M
authors.lastname: Perineau
authors.forename: X
authors.initials: X
authors.lastname: Monroziès
authors.forename: J M
authors.initials: JM
authors.lastname: Rème
mesh_terms: D002064:Buserelin / Q000627:therapeutic use; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D016729:Leuprolide / Q000627:therapeutic use; D007986:Luteinizing Hormone / Q000097:blood; D008596:Menotropins / Q000627:therapeutic use; D010048:Ovarian Cysts / Q000503:physiopathology*; D006080:Ovarian Follicle / Q000503:physiopathology; D011247:Pregnancy; D012189:Retrospective Studies; D017329:Triptorelin Pamoate / Q000627:therapeutic use
chemical_list: D017329:Triptorelin Pamoate; D004958:Estradiol; D008596:Menotropins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D016729:Leuprolide; D002064:Buserelin