title: Synthesis and antibacterial activity of 1-substituted-methyl carbapenems.
abstract: The synthesis of the 1 alpha- and the 1 beta-substituted (fluoro, cyano, hydroxy and acetoxy)-methyl carbapenems having a 2-(1,3,4-thiadiazol-2-yl)thiomethyl side chain are described, and their in vitro antibacterial activities are compared with the corresponding 1 beta-methyl carbapenems together with imipenem. The synthesis and antibacterial activity of the 1 beta-substituted (fluoro and cyano)-methyl carbapenems having 2-(1-alkyl-4-pyridinio)thiomethyl side chains are also described.
authors.affiliation: Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Sendo
authors.forename: M
authors.initials: M
authors.lastname: Kii
authors.forename: M
authors.initials: M
authors.lastname: Sakanoue
authors.forename: K
authors.initials: K
authors.lastname: Motokawa
authors.forename: Y
authors.initials: Y
authors.lastname: Kimura
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D015780:Carbapenems / Q000138:chemical synthesis* / Q000494:pharmacology; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems