[Burgdorf's reaction (painful acral erythema) in patients with acute lymphoblastic leukemia following medium-dose methotrexate therapy].
Erythematous changes of the palms with associated oedema, blistering and desquamation were observed in two children during chemotherapy for acute lymphoblastic leukaemia, after methotrexate in doses of 1,000 mg/m2. These changes correspondent to those described in the literature as Burgdorf's reaction. In Poland it was never reported as yet.
Wysocki
M
M
Katedry i I Kliniki Chorób Dzieci Ak. Med., Bydgoszczy.
Nowaczyk-Michalak
A
A
Pilecki
O
O
Kurylak
A
A
Balcar-Boroń
A
A
Trybuś
L
L
D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004890:Erythema / Q000139:chemically induced*; D005260:Female; D006229:Hand Dermatoses / Q000139:chemically induced*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D010146:Pain / Q000139:chemically induced; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*
D008727:Methotrexate
Reakcja Burgdorfa ("painful acral erythema") po leczeniu pośrednimi dawkami methotreksatu chorych z ostra białaczka limfoblastyczna.