title: Local signalling in dermomyotomal cell type specification.
abstract: The development and differentiation of the avian myotome was studied after removal of the neural tube, including neural crest, and after replacement of dorsal half-somites by ventral half-somites. Results show that in the absence of neural tissue myoblast differentiation within the somites does not take place. Ventral half-somites are able to undergo muscle differentiation if they were grafted in place of dorsal half somites. It is suggested that local signals must be responsible for the dorsalisation of the newly formed somite including myoblast differentiation. Neural crest cells are discussed as possible sources of these signals.
authors.affiliation: Anatomisches Institut, Albert-Ludwigs-Universität Freiburg, Federal Republic of Germany.
authors.forename: B
authors.initials: B
authors.lastname: Christ
authors.forename: B
authors.initials: B
authors.lastname: Brand-Saberi
authors.forename: M
authors.initials: M
authors.lastname: Grim
authors.forename: J
authors.initials: J
authors.lastname: Wilting
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002642:Chick Embryo; D003370:Coturnix / Q000196:embryology*; D005121:Extremities / Q000196:embryology; D007124:Immunoenzyme Techniques; D009132:Muscles / Q000166:cytology / Q000196:embryology*; D009432:Neural Crest / Q000166:cytology / Q000196:embryology*