Effect of single gallium arsenide exposure on some biochemical variables in porphyrin metabolism in rats.
Gallium arsenide (GaAs) inhibited, dose dependently, delta-aminolevulinic acid dehydratase (ALAD) activity in blood (as observed on days 1, 7 and 15), liver and brain (on day 15) after a single oral treatment. Levels of blood zinc protoporphyrin (ZPP) and urinary delta-aminolevulinic acid (ALA) excretion were elevated on day 7 and day 15 following exposure to 2000 mg kg-1 GaAs. A dose-dependent increase in blood As contents was observed while blood Ga was detectable only at higher doses.
Flora
S J
SJ
Division of Pharmacology and Toxicology, Defence Research & Development Establishment, Gwalior, India.
Das Gupta
S
S
D000284:Administration, Oral; D000596:Amino Acids / Q000652:urine; D021542:Amino Acids, Neutral; D000818:Animals; D001151:Arsenic / Q000633:toxicity*; D001152:Arsenicals; D004305:Dose-Response Relationship, Drug; D005708:Gallium / Q000633:toxicity*; D008297:Male; D000623:Porphobilinogen Synthase / Q000037:antagonists & inhibitors / Q000097:blood; D011524:Protoporphyrins / Q000378:metabolism*; D051381:Rats
D000596:Amino Acids; D021542:Amino Acids, Neutral; D001152:Arsenicals; D011524:Protoporphyrins; C017803:zinc protoporphyrin; C043055:gallium arsenide; C013809:5-aminovaleric acid; D005708:Gallium; D000623:Porphobilinogen Synthase; D001151:Arsenic