title: Pleomorphic xanthoastrocytoma of the brain: MR findings in six patients.
abstract: OBJECTIVE
  Pleomorphic xanthoastrocytoma is a rare, usually benign brain tumor. This pleomorphic supratentorial tumor involves the leptomeninges and superficial cortex in young patients with seizures. The MR imaging features of this distinct tumor have not been reported. We describe the MR imaging findings in six patients with pathologically proved pleomorphic xanthoastrocytoma.
  
  
  METHODS
  We retrospectively reviewed the MR images of six patients with pathologically proved pleomorphic xanthoastrocytoma. MR images were reviewed by two neuroradiologists. The pathologic slides of the tumors were reviewed by two neuropathologists. We also analyzed the patients' clinical features.
  
  
  RESULTS
  Most of the tumors were cortical based and isointense with gray matter on T1-weighted images and mildly hyperintense on T2-weighted images. All the masses enhanced with contrast material. Cystic components and gyriform and leptomeningeal enhancement were seen occasionally. The tumors occurred in the temporal lobes in four of the six patients. Three patients had seizures, and the other three had headaches.
  
  
  CONCLUSIONS
  Pleomorphic xanthoastrocytoma is a rare, usually benign, cortical-based mass that often enhances intensely with contrast material. The most common location is in the temporal lobes. Seizures and headaches are common clinical features. Familiarity with this lesion is important in the differential diagnosis of enhancing cortical-based masses.
authors.affiliation: Department of Radiology, Duke University Medical Center, Durham, NC 27710.
authors.forename: R D
authors.initials: RD
authors.lastname: Tien
authors.forename: C A
authors.initials: CA
authors.lastname: Cardenas
authors.forename: S
authors.initials: S
authors.lastname: Rajagopalan
mesh_terms: D000293:Adolescent; D000328:Adult; D001254:Astrocytoma / Q000175:diagnosis* / Q000473:pathology; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies