title: Osteolysis after silicone arthroplasty.
abstract: A young woman with a silicone lunate prosthesis for avascular necrosis developed painful lytic lesions in the distal ulna and the triquetrum. At reoperation, abundant reactive synovitis was found extending into those bone lesions. Histologic examination of the curetting samples revealed granulation tissue with histiocytes and many multinucleated giant cells containing refractile particles consistent with silicone. The authors report a giant cell lesion of the bone that radiographically and microscopically mimicked a neoplasm.
authors.affiliation: Department of Pathology, New England Deaconess Hospital, Boston, Massachusetts 02215.
authors.forename: S L
authors.initials: SL
authors.lastname: Harboldt
authors.forename: G J
authors.initials: GJ
authors.lastname: Gumley
authors.forename: K
authors.initials: K
authors.lastname: Balogh
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010014:Osteolysis / Q000139:chemically induced* / Q000473:pathology; D019736:Prostheses and Implants; D011859:Radiography; D012828:Silicones / Q000009:adverse effects* / Q000627:therapeutic use; D014955:Wrist Joint / Q000000981:diagnostic imaging / Q000601:surgery*
chemical_list: D012828:Silicones