title: [Experience with the use of streptokinase in acute myocardial infarct at the prehospital stage].
abstract: The authors analyze the experience gained with the systemic thrombolytic therapy (STLT) at the prehospital stage of the treatment of acute myocardial infarction by specialized emergency cardiological teams. The screening of patients to be given STLT was performed via the remote diagnostic center. STLT was provided to 43 patients who were given intravenous injections of 500,000 PU streptokinase (Avalizin, GDR) for 15-30 minutes. The control group included 16 patients given standard therapy. After STLT 62.8% of the patients demonstrated moderate arterial hypotension, which could readily be corrected. Myocardial reperfusion after STLT manifested by rapid removal of the painful syndrome, characteristic dynamics of ECT, and by the appearance of specific reperfusion disorders of rhythm and conduction. The accelerated idioventricular rhythm, ventricular premature heart beat and A-V rhythm of the junction were recorded most frequently. The indicated rhythm disorders were removed readily enough. It is recommended that STLT may be carried out at the prehospital stage of AMI treatment by the cardiological emergency teams, which is likely to appreciably enhance the efficacy of the given therapy form.
authors.forename: I E
authors.initials: IE
authors.lastname: Ganelina
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Varshavskiĭ
authors.forename: V I
authors.initials: VI
authors.lastname: Shal'nev
authors.forename: E A
authors.initials: EA
authors.lastname: Vasil'kova
authors.forename: K V
authors.initials: KV
authors.lastname: Zhuravlev
authors.forename: S Kh
authors.initials: SKh
authors.lastname: Fel'dman
authors.forename: A B
authors.initials: AB
authors.lastname: Khavezon
mesh_terms: D004562:Electrocardiography / Q000187:drug effects; D005392:First Aid; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D012008:Recurrence; D013300:Streptokinase / Q000008:administration & dosage*; D015912:Thrombolytic Therapy; D013997:Time Factors
chemical_list: D013300:Streptokinase
vernacular_title: Opyt primeneniia streptokinazy pri ostrom infarkte miokarda na dogospital'nom étape.