title: Efficacy and safety of 10-deazaaminopterin in the treatment of rheumatoid arthritis. A one-year continuation, double-blind study.
abstract: OBJECTIVE
  To determine the long-term safety and efficacy of 10-deazaaminopterin (10-DAM) in the treatment of rheumatoid arthritis (RA).
  
  
  METHODS
  A 1-year continuation of an initial 15-week randomized, double-blind clinical trial of 10-DAM and methotrexate (MTX).
  
  
  RESULTS
  10-DAM (n = 10) and MTX (n = 8) had comparable safety and efficacy profiles. One 10-DAM-treated and 2 MTX-treated patients experienced transient side effects; 1 MTX-treated patient experienced recurrent nausea and discontinued MTX.
  
  
  CONCLUSIONS
  10-DAM appears to be as beneficial and as safe as MTX for the treatment of RA.
authors.affiliation: Department of Medicine, University of Alabama, Birmingham 35294.
authors.forename: G S
authors.initials: GS
authors.lastname: Alarcón
authors.forename: O
authors.initials: O
authors.lastname: Castañeda
authors.forename: M
authors.initials: M
authors.lastname: Ferrándiz
authors.forename: C L
authors.initials: CL
authors.lastname: Krumdieck
authors.forename: W J
authors.initials: WJ
authors.lastname: Koopman
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D000630:Aminopterin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D001219:Aspartate Aminotransferases / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D005492:Folic Acid / Q000031:analogs & derivatives; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects / Q000627:therapeutic use; D008875:Middle Aged
chemical_list: D005492:Folic Acid; D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase; D000630:Aminopterin; C017178:10-deazaaminopterin; D008727:Methotrexate