MR imaging of experimental meningeal melanomatosis in nude rats.
MR imaging of the rat brain has become an increasingly frequently used method in experimental neuroradiology. On a generally available 1.5 T whole body tomograph, supplemented with an individually made small coil and a special SE sequence we obtained fairly fine images of the structures of the rat brain. With gadolinium-DTPA, we were able to visualize posterior fossa and cervical leptomeningeal growth of intrathecally injected B16 melanoma in nude rats. Using MRI to follow experimental leptomeningeal metastasis, may provide a new means for diagnostic evaluation and preclinical testing of treatment modalities.
Martos
J
J
Department of Neuroradiology, University of Tübingen, Germany.
Petersen
D
D
Klose
U
U
Requardt
H
H
Buchholz
R
R
Ohneseit
P
P
Schabet
M
M
Voigt
K
K
D000818:Animals; D002946:Cisterna Magna / Q000473:pathology; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D008279:Magnetic Resonance Imaging; D008545:Melanoma / Q000175:diagnosis* / Q000473:pathology; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D009368:Neoplasm Transplantation; D009942:Organometallic Compounds; D004369:Pentetic Acid; D051381:Rats; D011923:Rats, Nude; D013116:Spinal Cord / Q000473:pathology
D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA