Enhanced chromosomal fragility in neuroblastoma: correlation with poor prognosis.
In a previous study we demonstrated spontaneous fragility and hypersensitivity to fragile site induction by aphidicolin in lymphocytes from some neuroblastoma patients and their parents. Here we report data based on a total of 40 patients and 37 families. Possible correlations between higher sensitivity to aphidicolin and a variety of personal and clinical characteristics were verified. Patients with a poor prognosis generally proved to be more susceptible to fragile site induction.
Vernole
P
P
Department of Public Health and Cell Biology, 2nd University of Rome, Italy.
Tedeschi
B
B
Melino
G
G
Pianca
C
C
Nicoletti
B
B
D000328:Adult; D000367:Age Factors; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology*; D011379:Prognosis; D012016:Reference Values