title: Short-course treatment of typhoid fever with ciprofloxacin in south India.
abstract: This study assessed the performance of short-course ciprofloxacin for the treatment of 34 adult patients with culture-positive typhoid fever. Patients received ciprofloxacin, 750 mg orally twice daily for 7 d. Measurement of response was based upon time from initial treatment to fever lysis, to afebrile state, and to symptom resolution. Ciprofloxacin-treated patients defervesced in a mean of 3.21 d (+/- 0.56), with stabilization of temperature in 4.0 +/- 0.73 d. After 90 d follow-up, no relapse or carrier was identified. Side effects during therapy were minimal.
authors.affiliation: Emory University School of Medicine, Atlanta, Georgia.
authors.forename: S
authors.initials: S
authors.lastname: Meskin
authors.forename: M S
authors.initials: MS
authors.lastname: Jacob
authors.forename: R
authors.initials: R
authors.lastname: Macaden
authors.forename: J S
authors.initials: JS
authors.lastname: Keystone
authors.forename: P E
authors.initials: PE
authors.lastname: Kozarsky
authors.forename: A N
authors.initials: AN
authors.lastname: Ramachadran
authors.forename: B
authors.initials: B
authors.lastname: Metchock
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D013997:Time Factors; D016896:Treatment Outcome; D014435:Typhoid Fever / Q000188:drug therapy*
chemical_list: D002939:Ciprofloxacin