Cell membranes as targets for anti-cancer drug action.
A variety of studies strongly hint that cell membranes can be important targets for new and existing anti-tumor drugs. Traditionally, the search for new anti-cancer agents has focused on compounds designed to act on the biosynthesis, stability or function of DNA; it may be timely, however, to broaden our search horizon and consider targets outside of the nucleus. Thus, the cell membrane as well as membraneous organelles may well play a key role in the future of anti-tumor drug development.
Daoud
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Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman 99164-6510.
D016475:3T3 Cells; D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D007425:Intracellular Membranes / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents