Studies on annelated [1,4]benzothiazines and [1,5]benzothiazepines, V. Synthesis and biological activity of N-2 alkylamino derivatives of 4,5-dihydro-s-triazolo[3,4-d]-1,5-benzothiazepine.
The synthesis of a new series of N-2 alkylamino derivatives of 4,5-dihydro-s-triazolo[3,4-d]-1,5-benzothiazepine has been accomplished starting from 2,3-dihydro-1,5-benzothiazepin-4(5H)ones and their 2-methyl and 2-aryl derivatives. All the compounds were tested in vitro for their antimicrobial activity, but none of them showed remarkable activity. The tricyclic compounds 7a-j, 8a-j, 9a-j, 10a-j, and 11a-j were also screened for their CNS activity in mice and several of them showed interesting activity.
Ambrogi
V
V
Istituto di Chimica Farmaceutica e Tecnica Farmaceutica, Università degli Studi di Perugia, Italy.
Giampietri
A
A
Grandolini
G
G
Perioli
L
L
Ricci
M
M
Tuttobello
L
L
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D051379:Mice; D008826:Microbial Sensitivity Tests; D011619:Psychotropic Drugs / Q000138:chemical synthesis* / Q000494:pharmacology; D013841:Thiazepines / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D011619:Psychotropic Drugs; D013841:Thiazepines