Volume measurement of multiple sclerosis lesions with magnetic resonance images. A preliminary study.
The ability to visualise multiple sclerosis lesions in vivo with magnetic resonance imaging suggests an important role in monitoring the course of the disease. In order to help the long-term assessment of prospective treatments, a semi-automated technique for measuring lesion volume has been developed to provide a quantitative index of disease progression. Results are presented from a preliminary study with a single patient and compared to measurements taken from lesion outlines traced by a neuroradiologist, two neurologists and a technician. The semi-automated technique achieved a precision of 6% compared to a range of 12-33% for the manual tracing method. It also reduced the human interaction time from at least 60 min to 15 min.
Wicks
D A
DA
NMR Research Group, Institute of Neurology, London, UK.
Tofts
P S
PS
Miller
D H
DH
du Boulay
G H
GH
Feinstein
A
A
Sacares
R P
RP
Harvey
I
I
Brenner
R
R
McDonald
W I
WI
D001921:Brain / Q000473:pathology*; D003196:Computer Graphics; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D009103:Multiple Sclerosis / Q000473:pathology*; D009460:Neurologic Examination