Renal insufficiency induced by parathyroid hormone: influence of the calcium antagonist Gö 6070.
To study the pathogenesis of parathyroid-hormone-induced renal insufficiency and the influence of the new calcium channel antagonist Gö 6070 (Gödecke AG, Berlin, FRG) rats were assigned to three groups (n = 8 each): (1) control, (2) PTH, (3) PTH plus Gö 6070. PTH (30 micrograms/24 h, a nonhypercalcemic dose) was administered i.p. and Gö 6070 (1 mg/kg/24 h) p.o. for 6 days. PTH did not change plasma or urinary calcium and did not induce nephrocalcinosis. The glomerular filtration rate (GFR), however, was decreased (4.9 vs. 10.3 ml/min/kg). Concomitant administration of Gö 6070 attenuated the PTH-induced fall in GFR (6.2 ml/min/kg).
Strohmaier
W L
WL
Department of Urology, Medical School, Eberhard Karl University, Tübingen, FRG.
Seeger
D
D
Osswald
H
H
Bichler
K H
KH
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D008297:Male; D009287:Naphthyridines / Q000494:pharmacology*; D010281:Parathyroid Hormone / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar; D051437:Renal Insufficiency / Q000097:blood / Q000139:chemically induced* / Q000652:urine
D002121:Calcium Channel Blockers; C078495:Go 6070; D009287:Naphthyridines; D010281:Parathyroid Hormone