title: [Pertussis--an illness with typical clinical symptoms?].
abstract: There has been a noticeable increase in the incidence of pertussis in West Germany over the last decade. Since the availability of adequate bacteriological diagnosis a much broader clinical spectrum can be attributed to infections with B. pertussis. Three patients with an unusual clinical presentation of pertussis are presented. A three month old infant presented with severe apneic spells without cough as the sole clinical symptoms of the infection. B. pertussis was isolated in the nasopharyngeal swab. A nine month old premature infant with bronchopulmonary dysplasia after long time intubation and artificial ventilation presented with apneic spells, pulmonary and cardiac decompensation and required ventilatory support. The diagnosis was suggested by a massive leucocytosis with lymphocytosis. The diagnosis on the patient was established by serologic methods. Adult contacts of this patient developed longstanding cough and clinical signs of pertussis. The diagnosis of pertussis in these persons was established by nasopharyngeal culture. The third patient with trisomy 21 and a corrected AV canal suffered from nonspecific cough and gradually developed signs of congestive heart failure with pneumonia. B. pertussis was isolated from the nasopharynx. This patient showed neither the typical paroxysmal coughing spells nor disclosed the typical lymphocytosis in his white blood count. Microbiological investigations of patients with symptoms of respiratory tract infections should include the isolation of B. pertussis. Thus, additional cases of pertussis not suspected on the basis of their initial clinical presentation will be detected.
authors.affiliation: Universitätsklinik mit Poliklinik für Kinder und Jugendliche, Universität Erlangen/Nürnberg.
authors.forename: U
authors.initials: U
authors.lastname: Heininger
authors.forename: U
authors.initials: U
authors.lastname: Storr
authors.forename: M A
authors.initials: MA
authors.lastname: Uberall
authors.forename: J P
authors.initials: JP
authors.lastname: Guggenbichler
authors.forename: K
authors.initials: K
authors.lastname: Stehr
mesh_terms: D000284:Administration, Oral; D001886:Bordetella pertussis / Q000302:isolation & purification; D001997:Bronchopulmonary Dysplasia / Q000150:complications; D002675:Child, Preschool; D003490:Cyanosis / Q000209:etiology; D003937:Diagnosis, Differential; D004917:Erythromycin / Q000008:administration & dosage; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009305:Nasopharynx / Q000382:microbiology; D014917:Whooping Cough / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D004917:Erythromycin
vernacular_title: Keuchhusten--eine Erkrankung mit typischer klinischer Symptomatik?