title: Role of tear secretory IgA in hard contact lens-related changes in the tarsal conjunctiva.
abstract: The role of tear secretory IgA in contact lens-related conjunctival changes was investigated in 40 subjects (80 eyes) who wore polymethyl methacrylate (PMMA) contact lenses and 10 subjects (20 eyes) who did not wear contact lenses. The eyes in the contact lens group had significantly higher tear IgA levels than the control eyes (p < 0.05). We were not able to demonstrate a relation between increased IgA levels and the presence of symptoms or duration of contact lens wear. Increased IgA levels were correlated to papilla formation in the contact lens group. A rise in tear IgA levels seems to be the first abnormal change related to papilla formation in patients who wear PMMA contact lenses.
authors.affiliation: Department of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: J S
authors.initials: JS
authors.lastname: Saini
authors.forename: S
authors.initials: S
authors.lastname: Dhar
authors.forename: A
authors.initials: A
authors.lastname: Sharma
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003229:Conjunctival Diseases / Q000209:etiology*; D003261:Contact Lenses / Q000009:adverse effects*; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D007071:Immunoglobulin A, Secretory / Q000502:physiology*; D008297:Male; D020366:Methylmethacrylate; D008768:Methylmethacrylates; D013666:Tears / Q000502:physiology*
chemical_list: D007071:Immunoglobulin A, Secretory; D008768:Methylmethacrylates; D020366:Methylmethacrylate