Antisickling activity of hydroxybenzoic acids in Cajanus cajan.
The amounts of phenylalanine and hydroxybenzoic acid in a Cajanus cajan methanolic extract were estimated. Results showed that the amount of phenylalanine and hydroxybenzoic acid per gram weight of bean was 4.92 mg +/- 0.13 mg and 21.0 mg +/- 3.0 micrograms, respectively. Sickling inhibition was observed to be efficient with the extract which contains a mixture of phenylalanine (0.69 mg/ml) and p-hydroxybenzoic acid (10.5 micrograms/ml), equivalent to those found in bean extract. The additive antisickling effect of both compounds can be therapeutically exploited for the treatment of sickle cell anemia.
Akojie
F O
FO
Department of Chemistry, Loyola University of Chicago, Illinois 60626.
Fung
L W
LW
D000986:Antisickling Agents / Q000494:pharmacology*; D007887:Fabaceae / Q000737:chemistry*; D006801:Humans; D062385:Hydroxybenzoates / Q000032:analysis / Q000494:pharmacology; D010649:Phenylalanine / Q000032:analysis / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal
D000986:Antisickling Agents; D062385:Hydroxybenzoates; D010936:Plant Extracts; D010649:Phenylalanine