title: An antiplatelet aggregation principle and X-ray structural analysis of cis-khellactone diester from Peucedanum japonicum.
abstract: Three structurally related khellactone coumarins, 1-3, were isolated from the aerial parts of Peucedanum japonicum (Umbelliferae). Compound 2 was identified as a new coumarin (cis-3'-isovaleryl-4'-senecioylkhellactone) by spectral and chemical analysis. Conformation of the dihydropyrano ring of cis-3',4'-disenecioylkhellactone [3] was elucidated by X-ray crystallographic analysis. These three natural khellactone esters were subjected to the antiplatelet aggregation bioassay where cis-3',4'-diisovalerylkhellactone [1] showed significant activity (at 50 micrograms/ml).
authors.affiliation: Department of Chemistry, National Chunghsing University, Taichung, Taiwan, Republic of China.
authors.forename: T T
authors.initials: TT
authors.lastname: Jong
authors.forename: H C
authors.initials: HC
authors.lastname: Hwang
authors.forename: M Y
authors.initials: MY
authors.lastname: Jean
authors.forename: T S
authors.initials: TS
authors.lastname: Wu
authors.forename: C M
authors.initials: CM
authors.lastname: Teng
mesh_terms: D000818:Animals; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D011817:Rabbits; D014961:X-Ray Diffraction
chemical_list: D003374:Coumarins; D004365:Drugs, Chinese Herbal; D010975:Platelet Aggregation Inhibitors