title: Normal tissue plasminogen activator and plasminogen activator inhibitor activity in plasma from patients with type 1 diabetes mellitus.
abstract: The fibrinolytic system was investigated in 38 patients (21 males and 17 females) affected by type 1 diabetes mellitus (18 free from complications, 10 with retinopathy, and 10 with autonomic neuropathy) and in 8 healthy controls. Two separate fibrinolysis-stimulating tests were done: standardized venous occlusion and 1-desamino-8-D-arginine vasopressin infusion. Plasma tissue plasminogen activator antigen and activity and plasma plasminogen activator inhibitor activity were measured. All the patients were in good metabolic control (mean HbA1c 7.4%, range 6.1-8.0%). No significant differences were observed either between the diabetic patients and the control subjects, nor among the subgroups of diabetic patients. The fibrinolytic system is probably not involved in type 1 diabetes mellitus.
authors.affiliation: Department of Medicine, IRCCS H. S. Raffaele, Milano, Italy.
authors.forename: A M
authors.initials: AM
authors.lastname: Vicari
authors.forename: S
authors.initials: S
authors.lastname: Viganó D'Angelo
authors.forename: S
authors.initials: S
authors.lastname: Testa
authors.forename: G
authors.initials: G
authors.lastname: Comi
authors.forename: G
authors.initials: G
authors.lastname: Galardi
authors.forename: E
authors.initials: E
authors.lastname: Orsi
authors.forename: A
authors.initials: A
authors.lastname: D'Angelo
mesh_terms: D003894:Deamino Arginine Vasopressin / Q000494:pharmacology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003929:Diabetic Neuropathies / Q000097:blood; D003930:Diabetic Retinopathy / Q000097:blood; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D010959:Tissue Plasminogen Activator / Q000097:blood*
chemical_list: D017395:Plasminogen Activator Inhibitor 1; D010959:Tissue Plasminogen Activator; D003894:Deamino Arginine Vasopressin