title: Effect of "re du qing" on the activation, proliferation and membrane fluidity of lymphocytes.
abstract: Effects of Chinese Medicinal Preparation "Re Du Qing" (RDQ) on the activation, proliferation and membrane fluidity of T lymphocytes from human peripheral blood were studied by means of 3H-TdR incorporation and DPH fluorescence polarization. The results showed that "RDQ" can: 1) significantly inhibit the activation of T lymphocytes; 2) restrain the proliferation of activated T lymphoblasts in the presence of exogenous interleukin-2 (IL-2); and 3) increase the membrane fluidity of T lymphocytes and antagonize the decreased fluidity of lymphocyte membrane mediated by Con A or PHA. The functional abnormalities of T lymphocytes in some autoimmune diseases such as arthritis and the usefulness of RDQ in the treatment of these diseases were also discussed.
authors.affiliation: Department of Molecular Biology, Tongji Medical University, Wuhan.
authors.forename: G M
authors.initials: GM
authors.lastname: Zhang
authors.forename: T L
authors.initials: TL
authors.lastname: Hao
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Yang
authors.forename: Z H
authors.initials: ZH
authors.lastname: Feng
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Jiang
authors.forename: B
authors.initials: B
authors.lastname: Zhou
authors.forename: H
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007376:Interleukin-2; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects*; D051379:Mice; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects*
chemical_list: D004365:Drugs, Chinese Herbal; D007376:Interleukin-2