title: Benign epithelial neoplasms of the appendix: classification and clinical associations.
abstract: The nomenclature of non-carcinoid epithelial proliferations of the appendix is confused and many of the terms used have no histogenetic basis. A classification based on the well-established diagnostic categories of colonic epithelial polyps has been proposed recently. We have applied this classification to 42 benign epithelial lesions of the appendix in order to determine its suitability for routine diagnostic use, and in order to determine the prognosis of patients with these lesions. All lesions could be classified as either hyperplastic, adenomatous, mixed hyperplastic/adenomatous or dilated appendices. Six cases were associated with a synchronous carcinoma of the colon with all types of appendiceal histology being represented. Follow-up of the remainder of the patients revealed two subsequent colonic carcinomas, at 3 and 6 years post-appendicectomy respectively. In both of these patients, the appendix had shown adenomatous epithelium. We suggest that adenomas of the appendix may have a similar prognostic significance to adenomas elsewhere in the large bowel.
authors.affiliation: Department of Pathology, University of Southampton, Southampton General Hospital, UK.
authors.forename: G R
authors.initials: GR
authors.lastname: Williams
authors.forename: C E
authors.initials: CE
authors.lastname: du Boulay
authors.forename: W R
authors.initials: WR
authors.lastname: Roche
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001065:Appendix / Q000473:pathology*; D002277:Carcinoma / Q000453:epidemiology; D002430:Cecal Neoplasms / Q000145:classification / Q000473:pathology* / Q000503:physiopathology*; D003110:Colonic Neoplasms / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions; D011446:Prospective Studies; D012307:Risk Factors