Cardioprotective effect of cromakalim (potassium channel opener) in isoproterenol induced myocardial infarction in rats.
Animals pretreated with cromakalim (1 mg/kg,po) along with isoproterenol (85 mg/kg,sc) showed less myocardial degenerative changes on histopathological examinations when compared with those treated with isoproterenol alone. Cromakalim's beneficial effects on myocardium were in dose-dependent manner. Administration of cromakalim (po) lowered significantly the serum LDH and SGOT and depleted intracytoplasmic glycogen as demonstrated by periodic schiff staining procedure. Increase in blood clotting time was highly significant (P less than 0.001). The results suggest cardioprotective effect of cromakalim in isoproterenol induced myocardial infarction.
Aghi
M
M
Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India.
Husain
Z
Z
Pillai
K K
KK
Qadry
J S
JS
Balani
D K
DK
Imran
M
M
D000818:Animals; D001219:Aspartate Aminotransferases / Q000187:drug effects; D001578:Benzopyrans / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects; D019806:Cromakalim; D005260:Female; D006003:Glycogen / Q000378:metabolism; D007545:Isoproterenol; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced / Q000517:prevention & control*; D009206:Myocardium / Q000473:pathology; D011758:Pyrroles / Q000494:pharmacology*; D051381:Rats; D014665:Vasodilator Agents / Q000494:pharmacology*; D014700:Verapamil / Q000494:pharmacology
D001578:Benzopyrans; D011758:Pyrroles; D014665:Vasodilator Agents; D019806:Cromakalim; D006003:Glycogen; D014700:Verapamil; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D007545:Isoproterenol