A case of congenital leukemia with monosomy 7.
A case of congenital leukemia with monosomy 7 is reported. Immunological study of the blast cells using monoclonal antibodies was suggestive of both myelomegakaryocytic and T-lymphoblastic leukemia. Chromosomal analysis of the bone marrow cells showed monosomy 7. Chemotherapy was initiated with a combination of adriamycin, cytosine arabinoside, 6-mercaptopurine, and prednisolone. The patient obtained complete remission, which has been maintained for 4 years and 1 month. He receives no chemotherapy now. Our case shows that monosomy 7 in congenital leukemia is rare, but the presence of monosomy 7 in congenital leukemia does not necessarily indicate a poor prognosis.
Shitara
T
T
Department of Pediatrics, Gunma University School of Medicine, Japan.
Suetake
N
N
Yugami
S
S
Sotomatu
M
M
Oshima
Y
Y
Ijima
H
H
Kuroume
T
T
Nakazawa
S
S
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002897:Chromosomes, Human, Pair 7; D003561:Cytarabine / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D007938:Leukemia / Q000151:congenital* / Q000188:drug therapy / Q000235:genetics; D007947:Leukemia, Megakaryoblastic, Acute / Q000235:genetics / Q000473:pathology; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics / Q000473:pathology; D008297:Male; D015122:Mercaptopurine / Q000008:administration & dosage; D009006:Monosomy; D011239:Prednisolone / Q000008:administration & dosage; D012074:Remission Induction
D003561:Cytarabine; D004317:Doxorubicin; D011239:Prednisolone; D015122:Mercaptopurine