title: [The mechanisms of the ethomersol correction of postischemic hypoperfusion].
abstract: In rat experiments during brain ischemia (30-min carotid artery occlusion), ethomersol administered intraperitoneally in a dose of 50 mg/kg before occlusion or at the end of ischemia eliminated postischemic hypoperfusion. The effect of the drug was due to its spasmolytic and antiaggregatory activities. An analysis of the vasodilating action of ethomersol revealed its capacity to block potential-dependent calcium channels and partially intracellular calcium mobilization when the adrenergic and serotoninergic receptors were activated. The antiaggregatory activity of the drug appeared as inhibited platelet aggregation, which was induced by ADP, serotonin, arachidonic acid, thrombin, and as enhanced antiaggregatory activity of the vascular wall.
authors.forename: T M
authors.initials: TM
authors.lastname: Plotnikova
authors.forename: Z V
authors.initials: ZV
authors.lastname: Kulakova
authors.forename: V I
authors.initials: VI
authors.lastname: Smol'iakova
authors.forename: M B
authors.initials: MB
authors.lastname: Plotnikov
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D002546:Ischemic Attack, Transient / Q000150:complications / Q000188:drug therapy* / Q000517:prevention & control; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011817:Rabbits; D051381:Rats; D013997:Time Factors; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D001562:Benzimidazoles; D002121:Calcium Channel Blockers; D010975:Platelet Aggregation Inhibitors; D014665:Vasodilator Agents; C070941:ethomersol
vernacular_title: Mekhanizmy korrektsii étomerzolom postishemicheskoĭ gipoperfuzii.