title: [Effect of salvipholin on the carbohydrate and lipid metabolism in the rat liver in alloxan diabetes].
abstract: Peroral administration of salvipholin in a dose of 50 mg/kg to intact male rats (the body weight 180-220 g) had a positive effect on the carbohydrate-lipid metabolism in the liver and blood serum of animals. Administration of the same dose to rats with alloxan diabetes induced a significant decrease in the content of glucose, free fat acids, triglycerides and lysophospholipids of the liver and blood serum. The level of these components has sharply increased after subcutaneous alloxan administration in a dose of 150 mg/kg, the content of glycogen and pyruvic acid being normalized and insulin deficiency removed. These changes are closely related to salvipholin-promoted restoration of phospholipid spectra of the blood serum and liver of experimental animals disturbed under conditions of insulin deficiency. The possible mechanism of the salvipholin action is analyzed.
authors.forename: Z A
authors.initials: ZA
authors.lastname: Khushbaktova
authors.forename: M A
authors.initials: MA
authors.lastname: Tashmukhamedova
authors.forename: V N
authors.initials: VN
authors.lastname: Syrov
authors.forename: D T
authors.initials: DT
authors.lastname: Mirtalipov
authors.forename: I I
authors.initials: II
authors.lastname: Grunina
mesh_terms: D000818:Animals; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D004224:Diterpenes / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008246:Lysophospholipids / Q000378:metabolism; D008297:Male; D010743:Phospholipids / Q000097:blood / Q000378:metabolism*; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D051381:Rats; D012016:Reference Values; D014280:Triglycerides / Q000378:metabolism
chemical_list: D002241:Carbohydrates; D004224:Diterpenes; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D008055:Lipids; D008246:Lysophospholipids; D010743:Phospholipids; D011773:Pyruvates; D014280:Triglycerides; C077678:salvipholin; D019289:Pyruvic Acid; D006003:Glycogen; D005947:Glucose
vernacular_title: Vliianie sal'vifolina na uglevodnyĭ i lipidnyĭ obmen v pecheni krys v usloviiakh alloksanovogo diabeta.