title: Treatment of neutropenia in Felty's syndrome with granulocyte-macrophage colony-stimulating factor--hematological response accompanied by pulmonary complications with lethal outcome.
abstract: We report on a 67-year-old man with Felty's syndrome (FS) complicated by recurrent pneumonia and an infected wound, which was not healing in spite of maximal antibiotic and local therapy. Encouraged by previous experience, we treated him with granulocyte-macrophage colony-stimulating factor (GM-CSF). His total leukocyte count rose, but the patient's pneumonia deteriorated. In addition, a previously known chronic obstructive lung disease (COLD) was exacerbated acutely. These complications finally led to his death. Postmortem examination revealed widespread pneumonia with invasive aspergillosis and a peripheral adenocarcinoma in his left lung.
authors.affiliation: Department of Internal Medicine, Free University of Berlin, Federal Republic of Germany.
authors.forename: A R
authors.initials: AR
authors.lastname: Gari-Bai
authors.forename: C
authors.initials: C
authors.lastname: Rochlitz
authors.forename: M
authors.initials: M
authors.lastname: Riewald
authors.forename: J
authors.initials: J
authors.lastname: Oertel
authors.forename: D
authors.initials: D
authors.lastname: Huhn
mesh_terms: D000230:Adenocarcinoma / Q000150:complications; D000368:Aged; D001228:Aspergillosis / Q000150:complications; D005258:Felty Syndrome / Q000150:complications / Q000188:drug therapy*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D008171:Lung Diseases / Q000150:complications* / Q000188:drug therapy; D008173:Lung Diseases, Obstructive / Q000209:etiology; D008175:Lung Neoplasms / Q000150:complications; D008297:Male; D009503:Neutropenia / Q000150:complications / Q000188:drug therapy; D011014:Pneumonia / Q000150:complications / Q000188:drug therapy; D014946:Wound Infection / Q000150:complications / Q000188:drug therapy
chemical_list: D016178:Granulocyte-Macrophage Colony-Stimulating Factor