How long do we need to give antioxidant therapy during resuscitation when its administration is delayed for two hours?
Twenty-four guinea pigs with third-degree burns over 70% of the body surface area were divided equally into four groups. All animals received Ringer's lactate (R/L) beginning 30 minutes after burn injury. Group 1 received R/L without vitamin C beginning 2 hours after burn injury. Groups 2, 3, and 4 received R/L with vitamin C until 4, 8, and 24 hours after burn injury, respectively. Beginning 3 1/2 hours after burn injury the hourly fluid volume was reduced to 25% of the Parkland formula calculation. The hourly sodium and fluid intake in each group was the same. Groups 1 and 2 demonstrated higher hematocrit and lower cardiac output values as compared with those values for group 3, indicating hypovolemia and hemoconcentration in these groups. Group 3 showed hematocrit and cardiac output values equivalent to those values for group 4. We conclude that high-dose vitamin C must be given until 8 hours after burn injury to maintain adequate hemodynamic stability in the presence of a reduced resuscitation fluid volume.
Tanaka
H
H
Burn Center, Cook County Hospital, Chicago, IL 60612.
Broaderick
P
P
Shimazaki
S
S
Matsuda
H
H
Hansalia
H
H
Hanumadass
M
M
Reyes
H
H
Matsuda
T
T
D000704:Analysis of Variance; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use; D001794:Blood Pressure / Q000502:physiology; D002056:Burns / Q000188:drug therapy* / Q000503:physiopathology; D002199:Capillary Permeability / Q000502:physiology; D005260:Female; D006168:Guinea Pigs; D006400:Hematocrit; D006439:Hemodynamics; D008297:Male; D012151:Resuscitation; D013997:Time Factors
D000975:Antioxidants; D001205:Ascorbic Acid