[The effect of hepatoprotectors on the functional activity of rat hepatocyte mitochondria in in-vitro and in-vivo systems].
In in vitro experiments essential, flacumin, and silibor inhibited the respiratory activity of isolated mitochondria and failed to affect the respiration of hepatocytes in rats at condition 4 by Chance. Essential uncoupled mitochondrial oxidative phosphorylation in the in vitro system. The hepatoprotectors used in ethanol-induced abnormality restored the activity of mitochondrial oxidative phosphorylation of hepatocytes to its level in intact animals.
Gordienko
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AD
D000818:Animals; D004353:Drug Evaluation, Preclinical; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects*; D008108:Liver Diseases, Alcoholic / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D010713:Phosphatidylcholines / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats
D005419:Flavonoids; D010713:Phosphatidylcholines; C061938:silibor; C011246:essential 303 forte; C046959:flacumin
Vliianie gepatoprotektorov na funktsional'nuiu aktivnost' mitokhondriĭ gepatotsitov krys v sistemakh in vitro i in vivo.