title: Comparison of plasma prekallikrein levels in human skin blister and chamber fluids from volunteer subjects and psoriatic patients.
abstract: Suction blisters were successfully raised on lesional, perilesional and non-lesional skin of psoriatic patients. Similar blisters were created on the skin of volunteer subjects. A specific method has been established for the measurement of plasma prekallikrein, and validated for blister fluid, skin chamber fluid, plasma and synovial fluid. Combined levels of plasma prekallikrein and its active form were compared in blister fluids obtained from psoriatic patients and the volunteers. Significantly higher values for plasma prekallikrein were found in the non-lesional blister fluids of psoriatic patients when compared to the volunteer subjects.
authors.affiliation: Department of Pharmacology, School of Medical Sciences, University of Bristol.
authors.forename: N K
authors.initials: NK
authors.lastname: Thomas
authors.forename: G
authors.initials: G
authors.lastname: Marshman
authors.forename: K
authors.initials: K
authors.lastname: Worthy
authors.forename: J
authors.initials: J
authors.lastname: Burton
authors.forename: K D
authors.initials: KD
authors.lastname: Bhoola
mesh_terms: D001768:Blister / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D011288:Prekallikrein / Q000378:metabolism*; D011565:Psoriasis / Q000378:metabolism*; D012016:Reference Values; D012867:Skin / Q000378:metabolism*; D013582:Synovial Fluid / Q000378:metabolism
chemical_list: D011288:Prekallikrein