title: Nitroimidazoles, XIV: Synthesis of 4-nitroimidazoles with 1-substituents containing acid, ester or phenol functions, and radiosensitizing efficiency of some of these compounds.
abstract: 1,4-Dinitroimidazole and 1,4-dinitro-2-methylimidazole were reacted with aminocarboxylic acids and their esters, aminosulfonic acids, and aminophenol to obtain the corresponding 1-substituted-4-nitroimidazoles. The radiosensitizing efficiency of some esters of 2-(4-nitro-1-imidazolyl)alkanecarboxylic acids was tested.
authors.affiliation: Institute of Organic Chemistry and Technology, Silesian Technical University, Gliwice, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Suwinski
authors.forename: W
authors.initials: W
authors.lastname: Szczepankiewicz
authors.forename: M
authors.initials: M
authors.lastname: Widel
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D006224:Cricetinae; D003412:Cricetulus; D009593:Nitroimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D011838:Radiation-Sensitizing Agents / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D009593:Nitroimidazoles; D011838:Radiation-Sensitizing Agents