NSAID-induced gastroenteropathy: a biochemical dissection.
The most widely accepted view is that damage to the mucosa sets the stage for lesions related to NSAIDs. An alternative hypothesis is that NSAID-induced damage to GI microvasculature is the primary pathologic event.
Russo
P J
PJ
University of Health Sciences, College of Osteopathic Medicine-Kansas City, Mo.
Seidler
N W
NW
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000494:pharmacology; D004064:Digestive System / Q000098:blood supply; D005753:Gastric Mucosa / Q000187:drug effects; D006801:Humans; D008833:Microcirculation / Q000187:drug effects; D008954:Models, Biological; D010437:Peptic Ulcer / Q000139:chemically induced*
D000894:Anti-Inflammatory Agents, Non-Steroidal