[Modification of drug mutagenicity by their immobilization. Effect of prostatilen immobilized in polyvinyl alcohol in mice].
Mutagenic drug effect of prostatilen and the possibility of modification were analysed in the sperm head anomalies (SHA) and the bone marrow cell aberrations (CA) tests in Mus musculus. It was found that intraperitoneal injection of 2.5 micrograms of prostatilen induced no significant increase in SHA and CA frequencies, the dose of 5 micrograms inducing both SHA and CA. Ultrafiltration of prostatilen led to decrease in its mutagenicity in the SHA test. Immobilization of the drug (5 and 10 micrograms) in polyvinyl alcohol reduced SHA and CA frequencies, the former decreasing to the control level.
Mikheev
V S
VS
Bolonina
V P
VP
Gorbachev
A G
AG
D000818:Animals; D002869:Chromosome Aberrations / Q000235:genetics; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens / Q000633:toxicity*; D010455:Peptides / Q000633:toxicity*; D011142:Polyvinyl Alcohol; D014462:Ultrafiltration
D009153:Mutagens; D010455:Peptides; C069549:prostatilen; D011142:Polyvinyl Alcohol
Modifikatsiia mutagennosti lekarstvennykh preparatov putem ikh immobiizatsii. Effekt immobilizatsii prostatilena v polivinilovom spirte u mysheĭ.