Effect of lithium on the double-quantum behavior of 23Na in normal human erythrocytes.
The double-quantum behavior of 23Na in the presence of different concentrations of Li in human erythrocytes was investigated. The 23Na double-quantum signal was quenched in both the extracellular and the intracellular compartments with increasing concentration of Li in each compartment, along with an increase in the 23Na T1 both intra- and extracellularly. Some extracellular quenching could be observed at the near therapeutic concentration of 2 mM Li. The ratio of slow to fast spin-spin (T2) relaxation times, obtained from the dependence of the double-quantum signal on creation time, approached unity at an overall Li concentration of 40 mM. These results provide evidence that Li and Na compete for both intra- and extracellular binding sites in erythrocytes.
Gullapalli
R P
RP
Department of Electronics & Instrumentation, University of Arkansas, Little Rock 72204.
Hawk
R M
RM
Komoroski
R A
RA
D001667:Binding, Competitive; D004912:Erythrocytes / Q000187:drug effects*; D005110:Extracellular Space; D006801:Humans; D066298:In Vitro Techniques; D007424:Intracellular Fluid; D008094:Lithium / Q000494:pharmacology*; D011789:Quantum Theory; D012964:Sodium / Q000097:blood*
D008094:Lithium; D012964:Sodium