Beta-glucosidase activity towards a bile acid glucoside in human liver.
Human liver contains hydrolytic activity toward 3 beta-glucosido-chenodeoxycholic acid. This beta-glucosidase activity, localized predominantly in the microsomal fraction, was optimally active in the presence of divalent metal ions close to pH 5.0 and was inhibited by EDTA. Kinetic parameters and other catalytic properties of hydrolytic activity towards 3 beta-glucosido-chenodeoxycholic acid from human liver microsomes are described.
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Department of Internal Medicine III, Aachen University of Technology, Germany.
Gartzen
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D002413:Cations, Divalent / Q000494:pharmacology; D002451:Cell Compartmentation; D002635:Chenodeoxycholic Acid / Q000031:analogs & derivatives; D004492:Edetic Acid / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008099:Liver / Q000201:enzymology*; D008861:Microsomes / Q000201:enzymology; D013347:Subcellular Fractions / Q000201:enzymology; D001617:beta-Glucosidase / Q000037:antagonists & inhibitors / Q000378:metabolism*
D002413:Cations, Divalent; D002635:Chenodeoxycholic Acid; D004492:Edetic Acid; D001617:beta-Glucosidase