Endothelin does not affect experimentally induced corneal neovascularization.
Endothelin, a potent vasoconstrictor, was found to be ineffective in the treatment of experimentally induced corneal neovascularization. Endothelin was administered topically, subconjunctivally, and intraluminally in serial concentrations ranging from 0.0005 to 5.0 micrograms/mL in New Zealand white rabbits without effect. Electron microscopy of the neovascular cornea revealed the vessels consisted only of endothelin and pericytes. Hence, the vessels were not responsive to endothelin because they lacked contractile smooth muscle.
Eiferman
R A
RA
Department of Ophthalmology & Visual Sciences, University of Louisville, Kentucky 40292.
Stagner
J
J
Jumblatt
M
M
O'Neill
K P
KP
Smith
D A
DA
D000818:Animals; D016510:Corneal Neovascularization / Q000188:drug therapy* / Q000473:pathology; D004195:Disease Models, Animal; D016232:Endothelins / Q000008:administration & dosage* / Q000627:therapeutic use; D007267:Injections; D009883:Ophthalmic Solutions; D011817:Rabbits
D016232:Endothelins; D009883:Ophthalmic Solutions