[Postvaccinal reactions to simultaneous administration of the triple viral, oral polio and diphtheria-tetanus vaccines compared with their administration in sequence].
OBJECTIVE
To compare the frequency and characteristics of post-vaccination reactions, between on the one hand the simultaneous administration of the Oral Antipolio (OP), the Triple Virus (TV) and the Anti-Diphtheria and Anti-Tetanus (DT) vaccines; and on the other hand, their administration in sequence.


METHODS
Prospective study with interventions, with a non-random, non-blind determination. SITE. Survey covering the mothers of infants vaccinated at 24 vaccination centres in Mála province.


METHODS
490 infants vaccinated during their second year of life. 263 had the vaccines administered simultaneously and 227 in sequence.


METHODS
Simultaneous administration of the TV, OP and DT vaccines at 15 months; as against the administration of TV at 15 months, followed by OP and DT at 18 months.


RESULTS
78 infants (29.66%) suffered a reaction that could be attributed to the vaccination after the simultaneous administration of TV, OP and DT; and 86 infants (37.88%) after one of the two occasions of vaccination in the administration in sequence: 27.31% after the TV, 17.18% after the OP-DT and 6.62% after both.


CONCLUSIONS
The safety of simultaneous administration, taken together with data coming from other studies on its immunogenic effectiveness, reaffirms the usefulness of simultaneous administration of TV, OP and DT vaccines at 15 months, as a strategy to improve vaccine coverage of infants in their second year of life.
Jiménez Puente
A
A
Gerencia Provincial del Servicio Andaluz de Salud, Málaga.
Cejas Hermoso
P
P
Luna del Castillo
J D
JD
Valles Casado
L M
LM
Benítez Bocanegra
S
S
Cortés Martínez
C
C
Fernández Echegaray
R
R
Fernández Navarro
B
B
González Pérez
Y
Y
Moreno Sánchez
E
E
D000367:Age Factors; D004168:Diphtheria Toxoid / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007223:Infant; D011055:Poliovirus Vaccine, Oral / Q000008:administration & dosage* / Q000009:adverse effects; D013745:Tetanus Toxoid / Q000008:administration & dosage* / Q000009:adverse effects; D013997:Time Factors
D004168:Diphtheria Toxoid; D011055:Poliovirus Vaccine, Oral; D013745:Tetanus Toxoid
Reacciones posvacunales tras la administración simultánea de vacunas triple vírica y antipolio oral-difteria-tétanos, frente a su administración secuencial.