title: Solid-state stability testing of drugs by isothermal calorimetry.
abstract: A new technique has been developed to calculate rapidly the solid-state room-temperature degradation rate of drugs and drug candidates. The technique utilizes measurements of the initial rate of heat output at several elevated temperatures by isothermal calorimetry and the degradation rate of the compound determined at a single elevated temperature by chromatography. The activation energies and degradation rates at 25 degrees C calculated by conventional methods and by isothermal calorimetry are compared and discussed. The compounds studied were phenytoin, triamterene, digoxin, tetracycline, theophylline, diltiazem, and several proprietary ICI compounds.
authors.affiliation: ICI Pharmaceuticals Group, ICI Americas, Wilmington, Delaware 19897.
authors.forename: M J
authors.initials: MJ
authors.lastname: Koenigbauer
authors.forename: S H
authors.initials: SH
authors.lastname: Brooks
authors.forename: G
authors.initials: G
authors.lastname: Rullo
authors.forename: R A
authors.initials: RA
authors.lastname: Couch
mesh_terms: D002151:Calorimetry / Q000379:methods; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D007700:Kinetics; D013696:Temperature; D013752:Tetracycline / Q000737:chemistry; D013816:Thermodynamics
chemical_list: D013752:Tetracycline