title: Management of long-term postirradiation periclavicular complications.
abstract: Four cases of periclavicular postirradiation sarcoma and two cases of clavicular osteoradionecrosis with pathologic fractures are reported. All six cases presented more than 10 years after irradiation for breast cancer (five) or nasopharyngeal carcinoma (one). A review of radiotherapy received showed that they were subjected to unconventional radiation schedules (hypofractionation or high dose per fraction treatment). An approach to diagnosis and management of periclavicular lesions arising long after therapeutic irradiation is presented and the unique problems encountered with periclavicular surgery are discussed.
authors.affiliation: University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Ontario, Canada.
authors.forename: E H
authors.initials: EH
authors.lastname: Wang
authors.forename: A
authors.initials: A
authors.lastname: Sekyi-Otu
authors.forename: B
authors.initials: B
authors.lastname: O'Sullivan
authors.forename: R S
authors.initials: RS
authors.lastname: Bell
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000209:etiology / Q000628:therapy; D001943:Breast Neoplasms / Q000532:radiotherapy; D002968:Clavicle / Q000528:radiation effects*; D005260:Female; D005598:Fractures, Spontaneous / Q000209:etiology / Q000628:therapy; D005599:Fractures, Ununited / Q000209:etiology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000628:therapy; D016609:Neoplasms, Second Primary / Q000209:etiology / Q000628:therapy; D010025:Osteoradionecrosis / Q000209:etiology / Q000628:therapy; D011832:Radiation Injuries / Q000628:therapy*; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage