Effect of platelet-derived growth factor-BB on indomethacin-induced gastric lesions in rats.
The effect of platelet-derived growth factor-BB (PDGF-BB) was evaluated in rats with indomethacin-induced gastric lesions. Animals were treated with either saline solution or several doses of PDGF-BB given orally. Rats treated with 0.1 nmol/kg PDGF-BB showed a statistically significant reduction of gastric damage. Higher doses did not produce any further reduction of gastric damage, and a return toward control values was observed. The effect on lesions was independent of inhibition of gastric acid secretion, since a dose of 0.1 nmol/kg of this growth factor failed to modify gastric acid secretion stimulated by pylorus ligation.
Guglietta
A
A
Dept. of Experimental Therapy, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan 48105.
Hervada
T
T
Nardi
R V
RV
Lesch
C A
CA
D000818:Animals; D005744:Gastric Acid / Q000378:metabolism; D007213:Indomethacin; D008297:Male; D010982:Platelet-Derived Growth Factor / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013272:Stomach Diseases / Q000139:chemically induced / Q000503:physiopathology*; D014945:Wound Healing / Q000187:drug effects*
D010982:Platelet-Derived Growth Factor; D007213:Indomethacin