Unilateral, but not bilateral, locus coeruleus lesions facilitate recovery from sensorimotor cortex injury.
This study investigates the role of the locus coeruleus in recovery from sensorimotor cortex injury. Unilateral locus coeruleus lesions given 2 weeks prior to unilateral sensorimotor cortex injury facilitate subsequent motor recovery compared to animals with only a sensorimotor cortex injury, while bilateral locus coeruleus lesions severely retard motor recovery. The results suggest that recovery of function from the cortical injury is facilitated as long as a sufficient amount of the noradrenergic system remains intact, perhaps to provide a basis for compensatory sprouting. The results also suggest that recovery does occur in the absence of the locus coeruleus, indicating that the noradrenergic system is not necessary for recovery to occur after the cortical injury.
Boyeson
M G
MG
Department of Rehabilitation Medicine, University of Wisconsin Medical School, Madison 53706.
Krobert
K A
KA
Grade
C M
CM
Scherer
P J
PJ
D000818:Animals; D001923:Brain Chemistry / Q000502:physiology; D008125:Locus Coeruleus / Q000033:anatomy & histology / Q000502:physiology*; D008297:Male; D009638:Norepinephrine / Q000502:physiology; D016627:Oxidopamine; D051381:Rats; D017207:Rats, Sprague-Dawley; D013003:Somatosensory Cortex / Q000033:anatomy & histology / Q000293:injuries*; D013563:Sympathectomy, Chemical
D016627:Oxidopamine; D009638:Norepinephrine