Semi-selective immunoadsorption treatment in myasthenia gravis.
We treated some patients with severe generalized myasthenia gravis (MG) with semi-selective adsorption by plasma perfusion(PP) on IM-T350 column. We studied efficiency and undesired effects of the employed material to verify the safety and effectiveness of methodology. Thus a treatment protocol has been prepared: 6 PP per treatment cycle; 3-7 days between PP sessions; plasma to treat per session 1,2 lt; only one adsorbent column for every cycle. Our experience, on 13 cycles of treatment, showed that PP in autoimmune MG has provided good clinical results without any improvement in genetic MG.
Splendiani
G
G
Cattedra di Nefrologia, Università di Roma Tor Vergata, Italy.
Passalacqua
S
S
Barbera
G
G
Sturniolo
G
G
Costanzi
S
S
Fulignati
P
P
Casciani
C U
CU
D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D005260:Female; D006801:Humans; D007163:Immunosorbent Techniques; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000276:immunology / Q000628:therapy*; D010951:Plasma Exchange; D011950:Receptors, Cholinergic / Q000276:immunology; D014364:Tryptophan
D001323:Autoantibodies; D011950:Receptors, Cholinergic; D014364:Tryptophan