title: Age-related variations of enzymatic defenses against free radicals and peroxides.
abstract: Superoxide dismutase, glutathione peroxidase and catalase are the three main enzymatic systems of defense of the organism against free radicals and peroxides. A survey of the literature shows that no general tendency of evolution of these systems in aging emerges, even if some recent studies in humans demonstrate the existence of a concomitant decrease in most of the antioxidant enzymes in blood of the elderly. The study of the antioxidant systems and their interrelations in the elderly represents a large field of future investigations.
authors.affiliation: Centre de Médecine Préventive, Vandoeuvre-lès-Nancy, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Artur
authors.forename: B
authors.initials: B
authors.lastname: Herbeth
authors.forename: L
authors.initials: L
authors.lastname: Guémouri
authors.forename: E
authors.initials: E
authors.lastname: Lecomte
authors.forename: C
authors.initials: C
authors.lastname: Jeandel
authors.forename: G
authors.initials: G
authors.lastname: Siest
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002374:Catalase / Q000378:metabolism*; D005609:Free Radicals; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008875:Middle Aged; D010545:Peroxides / Q000378:metabolism*; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D010545:Peroxides; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase