Effect of a newly synthesized leukotriene antagonist, (E)-2,2-diethyl-3'-2-2-(4-isopropyl) thiazolyl ethenyl succinanilic acid (MCI-826), on immunological liver injury and nephritis in mice.
The effect of a newly synthesized leukotriene antagonist, (E)-2,2-diethyl-3'-2-2-(4-isopropyl) thiazolyl ethenyl succinanilic acid (MCI-826), on liver injury and nephritis in mice was studied. In order to confirm the anti-leukotriene activity of MCI-826, the effect of MCI-826 on leukotriene C4(LTC4)- and leukotriene D4(LTD4)-induced vasculitis, liver and kidney injury was studied. MCI-826 was found to clearly inhibit LTC4- and LTD4-induced vasculitis, as well as liver and kidney injury. In addition to LT-induced reactions, MCI-826 inhibited liver injury induced by injection of either an anti-basic liver protein antibody into DBA/2 mice that had been previously immunized with rabbit IgG or of a bacterial lipopolysaccharide (LPS) into Corynebacterium parvum pretreated DDY mice. Moreover, MCI-826 inhibited nephritis, caused by injecting antiglomerular basement membrane antibody into C57BL/6 mice. These results suggest that MCI-826 can be applied to the treatment of certain tissue inflammatory diseases.
Nagai
H
H
Department of Pharmacology, Gifu Pharmaceutical University, Japan.
Kitagaki
K
K
Miura
T
T
Shimazawa
T
T
Koda
A
A
D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology; D005921:Glomerulonephritis / Q000209:etiology / Q000517:prevention & control*; D007668:Kidney / Q000187:drug effects / Q000293:injuries; D020024:Leukotriene Antagonists; D008099:Liver / Q000187:drug effects* / Q000293:injuries; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D011239:Prednisolone / Q000494:pharmacology; D013189:SRS-A / Q000037:antagonists & inhibitors; D013844:Thiazoles / Q000494:pharmacology*; D014657:Vasculitis / Q000209:etiology / Q000517:prevention & control
D020024:Leukotriene Antagonists; D013189:SRS-A; D013844:Thiazoles; C077265:MCI 826; D003520:Cyclophosphamide; D011239:Prednisolone