Purification and partial characterization of anti-inflammatory peptide from pilose antler of Cervus nippon Temminck.
An anti-inflammatory compound was purified and isolated from pilose antler of Cervus nippon Temminck by dialysis, gel filtration and ion-exchange chromatography techniques. HPLC and N-terminal amion acid analysis identified the compound as a homogeneous peptide. The peptide is composed of 68 amino acids and its molecular weight as determined by amino analysis, is about 7200.
Zhang
Z Q
ZQ
Department of Pharmacology, Academy of Traditional Chinese Medicine and Materia Medica of Jilin Province, Changchun.
Zhang
Y
Y
Wang
B X
BX
Zhou
H O
HO
Wang
Y
Y
Zhang
H
H
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D000999:Antlers / Q000737:chemistry*; D003670:Deer; D004487:Edema / Q000188:drug therapy; D008419:Materia Medica / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D051381:Rats
D000596:Amino Acids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D008419:Materia Medica; D010455:Peptides