[Pharmacokinetics of puerarin in rats, rabbits, and dogs].
The puerarin was determined by HPLC with fluorescence detection. The plasma concentration-time course of puerarin in rats and dogs after iv was best fitted to a two-compartment open model, while that in rabbits was best fitted to a three-compartment open model. Species specificity was found among rats, rabbits, and dogs, calculated with compartment model program. The T1/2 beta after iv puerarin 9 mg.kg-1 in rats, rabbits, and dogs were 11, 21, and 67 min, respectively. There were no significant differences in pharmacokinetic parameters after iv 4.5-30 mg.kg-1 to rabbits and dogs.
Jin
X L
XL
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
Zhu
X Y
XY
D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004285:Dogs; D005260:Female; D007529:Isoflavones / Q000493:pharmacokinetics*; D008297:Male; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
D007529:Isoflavones; C033607:puerarin