title: [The correction of the hepatotoxicity of antitubercular preparations with tocopherol acetate and riboxin].
abstract: It has been established in experiments on white rats that prolonged (for 2 weeks) intoxication with antituberculous drugs (isoniazid plus rifampicin plus pyrazinamide) results in cytolytic liver injury. This manifests by hyperaminotransferasemia, initiation of lipid peroxidation, suppression of the antioxidant system and bile production. Daily injections of tocopherol acetate (15 mg/kg) and riboxine (100 mg/kg) together with administration of antituberculous drugs reduce their hepatotoxicity. The combined use of these hepatoprotectors and antioxidants provides a dramatic increase of their efficacy in durable intoxication with antituberculous drugs.
authors.forename: N P
authors.initials: NP
authors.lastname: Skakun
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Slivka
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000506:poisoning / Q000633:toxicity*; D002908:Chronic Disease; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D007290:Inosine Diphosphate / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects*; D008297:Male; D011041:Poisoning / Q000188:drug therapy; D051381:Rats; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000627:therapeutic use; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
chemical_list: D000995:Antitubercular Agents; D014810:Vitamin E; D007290:Inosine Diphosphate; D024502:alpha-Tocopherol; D024505:Tocopherols
vernacular_title: Korrektsiia gepatotoksichnosti protivotuberkuleznykh preparatov tokoferola atsetatom i riboksinom.