Effect of prednisone priming followed by alfa-interferon in treatment of children with chronic hepatitis B: an interim analysis of a controlled trial.
A six-month analysis of a controlled trial on the treatment of chronic hepatitis B in children shows that prednisone priming followed by alpha-interferon 2A was effective in 6 of 9 treated patients in reducing HBV replication and disease activity.
Utili
R
R
Clinic of Infectious Diseases and Tropical/Subtropical Diseases, 1st Medical School University of Naples, Italy.
Sagnelli
E
E
Giusti
G
G
Ruggiero
G
G
Piccinino
F
F
Galanti
B
B
Adinolfi
L E
LE
Aprea
L
L
Cesaro
G
G
Digilio
L
L
D000293:Adolescent; D002648:Child; D004359:Drug Therapy, Combination; D005260:Female; D006509:Hepatitis B / Q000628:therapy*; D006515:Hepatitis B virus / Q000187:drug effects / Q000254:growth & development; D006521:Hepatitis, Chronic / Q000628:therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D011241:Prednisone / Q000627:therapeutic use*; D011446:Prospective Studies; D011994:Recombinant Proteins; D016896:Treatment Outcome; D014779:Virus Replication / Q000187:drug effects
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011241:Prednisone