Association between HLA class I antigens and response to interferon therapy in children with chronic HBV hepatitis.
In this preliminary study, children with chronic HBV hepatitis, as was also previously shown for adults, respond to interferon therapy in an HLA class I antigen dependent manner. If this can be confirmed on a large scale, HLA typing may serve as a useful indication of interferon-therapy responders.
Giacchino
R
R
I Clinica Malattie Infettive, Università di Genova, Italy.
Nocera
A
A
Timitilli
A
A
Cristina
E
E
Giambartolomei
G
G
Caocci
F
F
Cirillo
C
C
Barocci
S
S
D000483:Alleles; D002648:Child; D005805:Genes, MHC Class I; D015797:HLA-B35 Antigen / Q000032:analysis*; D006509:Hepatitis B / Q000276:immunology / Q000628:therapy*; D006521:Hepatitis, Chronic / Q000276:immunology / Q000628:therapy*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*
D015797:HLA-B35 Antigen; D016898:Interferon-alpha