[Interaction of mRNA of the p53 protein gene with ribosomal RNA].
By blot hybridization we found that DNA fragments of eukaryotic 18 and 28S rRNAs bind specifically with mRNA. In these experiments the in vitro transcribed mRNA of mouse gene p53 was used. In addition we found that both 18 and 28S rRNAs were able to form intermolecular complexes with mRNAs of several genes 18S rRNA-mRNA; 28S rRNA-mRNA, but fail to bind the antisense RNAs of the same genes. The experimental data allow to suppose that 18S and 28S rRNAs carry several fragments that are complementary to some fragments in the mRNA sequences.
Matveeva
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Chumakov
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PM
D000818:Animals; D001345:Autoradiography; D004271:DNA, Fungal / Q000378:metabolism; D005800:Genes, Fungal; D016158:Genes, p53; D051379:Mice; D005810:Multigene Family; D009693:Nucleic Acid Hybridization; D016372:RNA, Antisense / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D012337:RNA, Ribosomal, 18S / Q000378:metabolism*; D012339:RNA, Ribosomal, 28S / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics; D014158:Transcription, Genetic
D004271:DNA, Fungal; D016372:RNA, Antisense; D012333:RNA, Messenger; D012337:RNA, Ribosomal, 18S; D012339:RNA, Ribosomal, 28S
Vzaimodeĭstvie mRNK gena belka p53 s ribosomnoĭ RNK.