title: Correlation between puberty and the development of autoimmunity to spermatozoa in men with cystic fibrosis.
abstract: OBJECTIVE
  To test the hypothesis that puberty is a necessary factor in the pathogenesis of autoimmunity to sperm in men with cystic fibrosis (CF), we studied prepubertal and postpubertal males with CF versus an age-matched group of males with type 1 diabetes as controls.
  
  
  METHODS
  Sera from CF and diabetic males treated at University Hospital, State University of New York, Stony Brook, were tested by indirect immunobead binding for antisperm antibodies and by radioimmunoassay for testosterone (T), luteinizing hormone, and follicle-stimulating hormone. The finding of autoantibodies to spermatozoa was correlated with chronological age, as well as with clinical and hormonal pubertal status.
  
  
  RESULTS
  Autoimmunity to sperm, as detected by humoral antisperm antibodies, was documented solely in postpubertal males, as judged by hormonal and clinical criteria. Eighty-three percent of sexually mature CF males and 6.3% (1 of 16) diabetic males exhibited autoantibodies to sperm. These antibodies were only detected when serum T levels were > 8.7 nmol/L (250 ng/dL).
  
  
  CONCLUSIONS
  These results suggest that puberty, and presumably, active spermatogenesis is a requirement for the development of autoimmunity to sperm in men with CF.
authors.affiliation: Department of Obstetrics and Gynecology, Health Sciences Center, SUNY, Stony Brook 11794-8091.
authors.forename: R A
authors.initials: RA
authors.lastname: Bronson
authors.forename: W J
authors.initials: WJ
authors.lastname: O'Connor
authors.forename: T A
authors.initials: TA
authors.lastname: Wilson
authors.forename: S K
authors.initials: SK
authors.lastname: Bronson
authors.forename: F I
authors.initials: FI
authors.lastname: Chasalow
authors.forename: K
authors.initials: K
authors.lastname: Droesch
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood; D001324:Autoantigens / Q000276:immunology; D015551:Autoimmunity; D002648:Child; D003550:Cystic Fibrosis / Q000276:immunology*; D003920:Diabetes Mellitus / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D011627:Puberty / Q000502:physiology*; D013094:Spermatozoa / Q000276:immunology*; D013739:Testosterone / Q000097:blood
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D007074:Immunoglobulin G; D013739:Testosterone