[Radiotherapy for stage B prostate cancer].
Thirty five cases with stage B prostate cancer underwent radiotherapy to the primary lesion from 1965 to 1989 in our hospital. Twenty two of them were given radiotherapy alone and 13 were treated by radiotherapy combined with hormone therapy. Twenty nine of them were given 113 or 127 TDF (Time, Dose and Fraction) of external radiotherapy using linear accelerator. Three of the other 6 cases underwent external radiotherapy combined with administration of bleomycin and the others received intraoperative irradiation by electron beam. We defined on digital examination a reduction in the primary lesion as improvement and complete flattening as atrophy for evaluation of the treatment. Rates of the improvement were 95% in radiation, alone, and 100% in hormone and radiation combination. Atrophy rates were 62% in the former, and 92% in the latter. Five-year non-relapse rates were 85% and 100%, respectively. Four cases relapsed in the radiotherapy alone group, in which two cases given intraoperative irradiation relapsed in the primary lesion and another two given external radiotherapy in the pelvic nodes and required further treatment. One of the 2 relapsed cases with intraoperative irradiation has been alive with cancer and the other died from dissemination. One of the 2 relapsed cases with external radiotherapy has been alive and well and the other died at home without any information of death. One relapsed in the combination group at 130 months but has been alive despite gradually progressive dissemination for 185 months. All relapsed cases were those with atrophy group. No relapse was seen in cases without atrophy of the prostate.(ABSTRACT TRUNCATED AT 250 WORDS)
Kobayashi
T
T
Kawai
T
T
Tachibana
Y
Y
Yamauchi
T
T
Aizawa
T
T
D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D004967:Estrogens / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011471:Prostatic Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D015996:Survival Rate
D004967:Estrogens