[The effect of GABA-ergic agents on the blood electrolyte balance in acute craniocerebral trauma].
A study was made of the balance of potassium and sodium ions in red blood cells and blood plasma of rats with acute craniocerebral injury seen over time. It has been established that phenibut (50 mg/kg) and sodium hydroxybutyrate (0.2 g/kg) prevent electrolytic changes in blood at different periods of injury. The K+/Na+ ratio of red blood cells can be used as an objective indicator to characterize the time course of changes in craniocerebral injury and to evaluate the efficiency of its pharmacological correction.
Novikov
V E
VE
Chemodurova
L N
LN
D000208:Acute Disease; D000818:Animals; D001930:Brain Injuries / Q000097:blood / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D011188:Potassium / Q000097:blood; D051381:Rats; D012964:Sodium / Q000097:blood; D012978:Sodium Oxybate / Q000627:therapeutic use*; D013997:Time Factors; D014882:Water-Electrolyte Balance / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
D005680:gamma-Aminobutyric Acid; D012978:Sodium Oxybate; D012964:Sodium; D011188:Potassium; C008842:4-amino-3-phenylbutyric acid
Vliianie GAMK-ergicheskikh sredstv na élektrolitnyĭ balans krovi pri ostroĭ cherepno-mozgovoĭ travme.