title: Soybean agglutinin binds commonly to a subpopulation of small-diameter neurons in dorsal root ganglion, vascular endothelium and microglia in human spinal cord.
abstract: Soybean agglutinin (SBA) was used to identify the location of N-acetylgalactosaminyl glycoconjugates in human dorsal root ganglia (DRG) and spinal cord. SBA bound to a subpopulation of small-diameter neurons in DRG and their central projections. It also bound to microglia and vascular endothelium. Vascular endothelium, DRG neurons and microglia do not originate from the neural tube, but penetrate into the neural tube in the embryonic stage and thereafter are located in the spinal cord. SBA binding glycoconjugates may be responsible for cell-cell interaction between these three cell types and tissues in human spinal cord.
authors.affiliation: Department of Neurology, Kyoto University, School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nagao
authors.forename: H
authors.initials: H
authors.lastname: Kamo
authors.forename: I
authors.initials: I
authors.lastname: Akiguchi
authors.forename: J
authors.initials: J
authors.lastname: Kimura
mesh_terms: D000117:Acetylglucosamine / Q000378:metabolism; D000328:Adult; D000368:Aged; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism*; D005557:Formaldehyde; D005727:Ganglia, Spinal / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D037102:Lectins / Q000378:metabolism*; D008875:Middle Aged; D009457:Neuroglia / Q000166:cytology / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D037121:Plant Lectins; D030262:Soybean Proteins; D013116:Spinal Cord / Q000166:cytology / Q000378:metabolism*; D016707:Tissue Fixation; D010835:Phytohemagglutinins
chemical_list: D000117:Acetylglucosamine; D005557:Formaldehyde; D037102:Lectins; D037121:Plant Lectins; D030262:Soybean Proteins; C028824:soybean lectin; D010835:Phytohemagglutinins