Primary carcinoid tumor of the urinary bladder.
A 62-year-old woman who presented with urinary frequency and microscopic hematuria was found to have a 1.2 x 1.0 x 0.6-cm polypoid carcinoid tumor of the urinary bladder. The tissue resected from the base after removal of the polypoid lesion disclosed a small focus of residual carcinoid tumor, associated with Brunn's epithelial nests, cystitis cystica, and cystitis glandularis. Tumor cells exhibited strong argyrophilia and weak argentaffinity. Immunohistochemical staining reactions were strongly positive for chromogranin and serotonin, and electron microscopy revealed characteristic dense-core granules. Flow cytometric evaluation revealed an aneuploid cell population with a DNA index of 1.20.
Walker
B F
BF
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA.
Someren
A
A
Kennedy
J C
JC
Nicholas
E M
EM
D002276:Carcinoid Tumor / Q000737:chemistry / Q000473:pathology*; D002467:Cell Nucleus / Q000473:pathology; D002864:Chromogranins / Q000032:analysis; D003593:Cytoplasm / Q000473:pathology; D003594:Cytoplasmic Granules / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D008875:Middle Aged; D012701:Serotonin / Q000032:analysis; D001749:Urinary Bladder Neoplasms / Q000737:chemistry / Q000473:pathology*
D002864:Chromogranins; D012701:Serotonin