title: Location and type of gastric carcinoma in relation to pepsinogen I level in blood.
abstract: Serum pepsinogen I (PGI) levels were measured in 192 gastric carcinoma (GC) patients and 70 controls. Among GC patients serum PGI levels were not influenced by the following variables: age, sex, smoking, Borrmann's or Lauren's classification, tumor size, cellular differentiation, and layer of invasion. The mean serum PGI levels of tumors restricted to the body, antrum, or involving both areas were 64.8 +/- 37.6 ng/ml, 76.0 +/- 47.0 ng/ml, and 51.1 +/- 25.5 ng/ml, respectively (P < 0.005). Odds ratios of GC patients from the quartile of 262 serum PGI levels in the limits > or = 100 ng/ml, 70-99.9 ng/ml, 45-69.9 ng/ml, and < 45 ng/ml were 1.00, 0.76, 3.44, and 37.1, respectively (P < 0.001). The lower serum PGI levels of Chinese GC patients seem to be related to disease location rather than other characters of the tumor.
authors.affiliation: Dept. of Medicine, Veterans General Hospital, Taipei, Taiwan.
authors.forename: F Y
authors.initials: FY
authors.lastname: Chang
authors.forename: K H
authors.initials: KH
authors.lastname: Lai
authors.forename: T F
authors.initials: TF
authors.lastname: Wang
authors.forename: S D
authors.initials: SD
authors.lastname: Lee
authors.forename: Y T
authors.initials: YT
authors.lastname: Tsai
authors.forename: S H
authors.initials: SH
authors.lastname: Tsay
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001788:Blood Grouping and Crossmatching; D005260:Female; D006769:Hospitals, General; D006787:Hospitals, Veterans; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016017:Odds Ratio; D010435:Pepsinogens / Q000097:blood*; D012907:Smoking / Q000009:adverse effects; D013274:Stomach Neoplasms / Q000097:blood* / Q000453:epidemiology / Q000473:pathology; D013624:Taiwan / Q000453:epidemiology
chemical_list: D010435:Pepsinogens