A bactericidal monoclonal antibody specific for the lipooligosaccharide of Bordetella pertussis reduces colonization of the respiratory tract of mice after aerosol infection with B. pertussis.
A mouse immunoglobulin G3 monoclonal antibody specific for the core oligosaccharide moiety of the lipooligosaccharide (LOS) of Bordetella pertussis has been shown to have complement-dependent bactericidal activity. This monoclonal antibody exhibits bactericidal activity against strains of B. pertussis that express the LOS A phenotype. In addition this monoclonal antibody was effective in reducing colonization by B. pertussis in both the lungs and tracheas of mice after aerosol infection.
Mountzouros
K T
KT
Praxis Biologics, Inc., Rochester, New York 14623.
Kimura
A
A
Cowell
J L
JL
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D001886:Bordetella pertussis / Q000276:immunology*; D003165:Complement System Proteins / Q000276:immunology; D005260:Female; D008070:Lipopolysaccharides / Q000276:immunology*; D008168:Lung / Q000382:microbiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D014132:Trachea / Q000382:microbiology*; D014917:Whooping Cough / Q000517:prevention & control
D000911:Antibodies, Monoclonal; D008070:Lipopolysaccharides; C023023:lipid-linked oligosaccharides; D003165:Complement System Proteins