[Function, molecular structure and gene expression regulation of interleukin-10 (IL-10)].
Interleukin-10 has a variety of biological activities. Murine interleukin-10 inhibits cytokine production by Th2 cells in the presence of macrophages, enhances T cell proliferation, sustains the viability of B cells in vitro, induces class II MHC antigen expression on B cells, enhances mast cell proliferation in the presence of IL-3 and/or IL-4, and inhibits cytokine production by macrophages. Human interleukin-10 inhibits cytokine production by human T cells and reduces antigen-specific human T cell proliferation by downregulation of class II MHC antigen expression on monocytes. cDNA clones encoding murine and human interleukin-10 exhibit a strong homology to BCRFI in Epstein-Barr virus. BCRFI conserves only a part of interleukin-10 activities.
Nakahata
T
T
Department of Pediatrics, Shinshu University School of Medicine.
Tsuji
K
K
D000595:Amino Acid Sequence; D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D006801:Humans; D016753:Interleukin-10 / Q000502:physiology*; D008407:Mast Cells / Q000166:cytology / Q000378:metabolism; D008969:Molecular Sequence Data; D015394:Molecular Structure; D013601:T-Lymphocytes / Q000166:cytology*
D016753:Interleukin-10