The anti-inflammatory effect of erythromycin in zymosan-induced peritonitis of mice.
The anti-inflammatory effect of erythromycin was investigated using zymosan-induced peritonitis in mice. When mice were given erythromycin 10 mg/kg/day po for 28 days, a marked suppression of inflammatory responses, including the reduced influx of leucocytes, plasma exudation and prostaglandin E2 synthesis, was observed. However, neither a 7-day treatment with erythromycin nor a 28-day treatment with clindamycin suppressed the response. The anti-inflammatory activity induced after a 28-day treatment with erythromycin was comparable to the anti-inflammatory effect conferred by a 2-day treatment with dexamethasone 40 microgram/mouse/day. Thus, these data confirm previous studies which show that erythromycin can exert an anti-inflammatory effect when used over long periods of time.
Mikasa
K
K
Department of Internal Medicine II, Nara Medical University, Japan.
Kita
E
E
Sawaki
M
M
Kunimatsu
M
M
Hamada
K
K
Konishi
M
M
Kashiba
S
S
Narita
N
N
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001202:Ascitic Fluid / Q000737:chemistry; D001798:Blood Proteins / Q000032:analysis; D015232:Dinoprostone / Q000032:analysis; D004195:Disease Models, Animal; D004917:Erythromycin / Q000494:pharmacology*; D005260:Female; D051379:Mice; D010538:Peritonitis / Q000139:chemically induced / Q000188:drug therapy*; D013997:Time Factors; D017211:Treatment Failure; D015054:Zymosan
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001798:Blood Proteins; D004917:Erythromycin; D015054:Zymosan; D015232:Dinoprostone