Delayed hypersensitivity to 6-methyl-prednisolone in Henoch Schöenlein syndrome.
We report a case of allergic reaction to oral 6-methyl-prednisolone in a patient with Henoch Schöenlein syndrome. When this syndrome was first diagnosed the patient was started on 6-methyl-prednisolone orally and after 4 days he developed a pruriginous generalized maculo-papular eruption. The rash disappeared 1 week after withdrawal of 6-methyl-prednisolone. The skin tests performed 1 month after with main food allergens were negative. Patch test with 0.10 ml of solution containing 6-methyl-prednisolone 40 mg/ml was positive after 48 and 72 h. The cutaneous biopsy on the patch tested skin revealed a perivascular infiltrate of lymphocytes, histiocytes and eosinophils.
Astone
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Istituto di Clinica Medica, Università Cattolica del Sacro Cuore, Roma, Italy.
Romano
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Pietrantonio
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F
Garcovich
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Venuti
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Barone
C
C
D000328:Adult; D003875:Drug Eruptions / Q000209:etiology*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced*; D011695:IgA Vasculitis / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D011239:Prednisolone / Q000009:adverse effects* / Q000627:therapeutic use
D011239:Prednisolone