[Effect of re-utilization of cuprophan capillary dialysers with different liquids on their biocompatibility and effectiveness of elimination].
In 22 patients cuprophane capillary dialyzers reutilized in turn with four sets of liquids were used four times (Andante type in 13 and TAF-12 in 9 patients). The degree of biocompatibility and efficiency of elimination of small molecules was evaluated. During four-time reuse of dialyzers reutilized with sodium hypochlorite and with formaldehyde a reduction of intra-dialysis leukopenia, granulocytopenia and thrombocytopenia was not stated in blood of the patients. Activation of the complement system measured with the quantity of decrease of C3c fraction of the complement in the patients blood after 20 minutes of dialysis reduced essentially only at the fourth reuse of dialyzers (p < 0.01). Creatinine clearance measured always one hour after starting of the dialysis, did not change in succeeding reuse of dialyzers. Reutilization of dialyzers with hydrogen peroxide solution and formaldehyde caused essential reduction of ++intra-dialysis leukopenia and neutropenia (p < 0.001). There was lack of changes in ++intra-dialysis thrombocytopenia. Activation of the complement system was reduced essentially only after the fourth reuse of dialyzers (p < 0.001), but was also essentially lower (p < 0.05) than with dialyzers reutilized with sodium hypochlorite and with formaldehyde. Creatinine clearance practically did not change and at the fourth reuse of dialyzers it decreased on the average by 1.8%. Reutilization with acetic acid already at the second reuse of dialyzers essential (p < 0.001) and deepened decrease of intradialytic leukopenia and neutropenia and the activation of the complement system in course of succeeding reuses. Intradialytic thrombocytopenia was subjected to vestigal, not essential decrease. Creatinine clearance lowered a little but not essentially. At the fourth reuse of dialyzers it was lower on the average by 3.6% than the initial one. Reutilization with Dialina (stabilized blend of peracetic, acetic acid and hydrogen peroxide solution) caused essential (p < 0.001) and, in course of further reuses, deepening of lowering of intradialytic leukopenia and neutropenia as well as the activation of the complement system already at the second reuse. At the same time at the second and fourth reuse of dialyzers reutilized with Dialina the activation of the complement system was essentially lower than reutilized with the other liquids (p < 0.02). At the fourth reuse intradialytic thrombocytopenia also lowered essentially (p < 0.01). Creatinine clearance lowered a little more than with other liquids and at the second reuse of dialyzers was lower on the average by 5.6%, and at the fourth reuse--by 6.7% in relation to the new dialyzers.(ABSTRACT TRUNCATED AT 400 WORDS)
Orłowski
A
A
Oddział Dializy Szpitala ZOZ, Lubaniu.
Szepietowski
T
T
D000085:Acetates / Q000494:pharmacology* / Q000633:toxicity; D019342:Acetic Acid; D000293:Adolescent; D000328:Adult; D001672:Biocompatible Materials; D002482:Cellulose / Q000031:analogs & derivatives* / Q000494:pharmacology; D003404:Creatinine / Q000652:urine*; D005260:Female; D005557:Formaldehyde / Q000494:pharmacology* / Q000633:toxicity; D015312:Hemodialysis Solutions / Q000494:pharmacology* / Q000633:toxicity; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology* / Q000633:toxicity; D007676:Kidney Failure, Chronic / Q000628:therapy* / Q000652:urine; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D006435:Renal Dialysis / Q000295:instrumentation* / Q000379:methods; D012973:Sodium Hypochlorite / Q000494:pharmacology* / Q000633:toxicity; D013997:Time Factors
D000085:Acetates; D001672:Biocompatible Materials; D015312:Hemodialysis Solutions; D008567:Membranes, Artificial; D005557:Formaldehyde; D002482:Cellulose; C009865:cuprammonium cellulose; D003404:Creatinine; D006861:Hydrogen Peroxide; D012973:Sodium Hypochlorite; D019342:Acetic Acid
Wpływ reutylizacji róznymi płynami na biozgodność kuprofanowych dializatorów kapilarnych i efektywność eliminacji.