Combined effects of noise and cisplatin: short- and long-term follow-up.
The combined effects of noise exposure and intravenous cisplatin injection on electrophysiologic hearing thresholds in guinea pigs were studied with short-term and long-term follow-up. The combined effects on the permanent threshold shift were dependent on the order of exposure. A potentiation was achieved when noise exposure preceded cisplatin injection by 30 minutes or by 3 days. Cisplatin injection 2 or 3 days before noise exposure produced no significant potentiation or inhibition. The combined effects on the temporary threshold shift were not influenced by the sequence of exposure.
Laurell
G F
GF
Department of Physiology, Karolinska Institute, Stockholm, Sweden.
D000818:Animals; D001300:Audiometry, Evoked Response; D001305:Auditory Fatigue / Q000187:drug effects*; D001309:Auditory Threshold / Q000187:drug effects*; D002945:Cisplatin / Q000633:toxicity*; D005260:Female; D005500:Follow-Up Studies; D006168:Guinea Pigs; D006311:Hearing Disorders / Q000139:chemically induced; D006317:Hearing Loss, Noise-Induced / Q000209:etiology; D008297:Male; D009622:Noise / Q000009:adverse effects*; D013997:Time Factors
D002945:Cisplatin