title: High resolution CT in children with cystic fibrosis.
abstract: High resolution CT (HRCT) was performed in 24 children (median age 57.9 months) suffering from cystic fibrosis (CF). In 23 patients (one examination unacceptable because of motion artifacts) the most frequent finding was bronchial wall thickening, shown in 21 patients (91%), followed by bronchiectasis in 15 patients (65%). Less frequent findings were mucus plugging and patchy consolidations, which could be demonstrated in 11 patients each (48%). Findings were classified using a CT scoring system and including only irreversible pulmonary changes; a statistically significant correlation with lung function tests (FEV1/FVC; MEF50) could be established. HRCT to date seems to be the most valuable method to determine extent and severity of lung involvement in children with CF and should therefore be routinely used for the staging of this disease.
authors.affiliation: Mr-Institute, University of Vienna, Austria.
authors.forename: R
authors.initials: R
authors.lastname: Stiglbauer
authors.forename: H
authors.initials: H
authors.lastname: Schurawitzki
authors.forename: I
authors.initials: I
authors.lastname: Eichler
authors.forename: K A
authors.initials: KA
authors.lastname: Vergesslich
authors.forename: M
authors.initials: M
authors.lastname: Götz
mesh_terms: D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012129:Respiratory Function Tests; D014057:Tomography, X-Ray Computed