[The radioprotective effect of hypoxia on clonogenic cells of rat bone marrow stroma (KOE-F)].
A comparative study was made on the survival rate of cell-precursors of haemopoietic stroma, that form, in a rat bone marrow culture, colonies (clones) of fibroblasts (CFU-F) after gamma-irradiation of animals in the air or in a gas hypoxic mixture, containing 8% of O2 (GHM-8). Irradiation in GHM-8 was shown to increase the survival rate of CFU-F by 1.7 times (as compared to exposure in the air) as estimated by the total number of colonies that are formed in a culture; the radioprotective effect of GHM-8 was more pronounced for CFU-F which form dense colonies: DMF for dense and loose clones was 2.4 and 1.6 respectively.
Konopliannikov
A G
AG
Waĭnson
A A
AA
Kolesnikova
A I
AI
Zaĭtsev
A V
AV
Kal'sina
S Sh
SSh
Lepekhina
L A
LA
D000818:Animals; D001854:Bone Marrow Cells; D002470:Cell Survival; D010100:Oxygen / Q000502:physiology*; D011835:Radiation Protection / Q000379:methods*; D051381:Rats; D017208:Rats, Wistar; D013234:Stem Cells / Q000528:radiation effects*
D010100:Oxygen
Radiozashchitnoe deĭstvie gipoksii na klonogennye kletki stromy kostnogo mozga (KOE-F) krys.