title: [Evaluation of the tissue-to-blood partition coefficient R for physiological pharmacokinetic models].
abstract: The tissue-to-blood partition coefficient R, fraction of drug unbound in blood fB and intrinsic clearance of elimination organ/tissue Cl'L are important parameters used in physiological pharmacokinetic models. Simple equations to evaluate R by AUC were derived in this paper for single bolus iv, the tissue-to-blood partition coefficient of nonelimination organ/tissue was exactly the ratio of AUC between tissue and blood, those equations were examined by the experimental data of rats following iv ethoxybenzamide 20 mg.kg-1, and compared with other methods. Equations to evaluate fBCl'L and other parameters were also given for linear elimination model.
authors.affiliation: Nanjing Medical College, Department of Biomathematics, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Ding
authors.forename: D K
authors.initials: DK
authors.lastname: Huang
authors.forename: J P
authors.initials: JP
authors.lastname: Luo
mesh_terms: D000818:Animals; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D010599:Pharmacokinetics; D051381:Rats; D012457:Salicylamides / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D012457:Salicylamides; C018935:ethenzamide