Ketamine blocks cortical epileptic afterdischarges but not paired-pulse and frequency potentiation.
Cortical epileptiform afterdischarges (spike-and-wave rhythm) induced by low-frequency stimulation of the sensorimotor cortex were dose-dependently shortened by ketamine (10, 20 and 40 mg/kg, i.p.). Myoclonic jerking during stimulation was unaffected by ketamine whereas the same motor pattern accompanying afterdischarges was markedly suppressed by this drug. Paired-pulse as well as frequency potentiation of the cortical interhemispheric (transcallosal) responses were not significantly altered by the 40 mg/kg dose of ketamine. The two simple potentiation phenomena studied probably did not play a role in initiation of cortical epileptic afterdischarges.
Mares
P
P
Institute of Physiology, Czechoslovak Academy of Sciences, Videnska, Prague.
Lanstiakova
M
M
Vankova
S
S
Kubova
H
H
Velisek
L
L
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology / Q000503:physiopathology; D004558:Electric Stimulation; D004569:Electroencephalography / Q000187:drug effects; D004827:Epilepsy / Q000503:physiopathology*; D005071:Evoked Potentials / Q000187:drug effects; D007649:Ketamine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats
D007649:Ketamine