Researches on psychotropic agents. IV. Synthesis and neuropsychopharmacological effects of 1,3,4,14 b-tetrahydro-10-methyl-2H,10H- pyrazino[2,1-d] pyrrolo[1,2-b][1,2,5]benzotriazepine and its derivatives.
The synthesis and neuropsychopharmacological properties of new 1,3,4,14b-tetrahydro-2H,10H-pyrazino [2,1-d] pyrrolo [1,2-b] [1,2,5] benzotriazepine derivatives related to antidepressant agent aptazepine are reported. The new derivatives displayed sedative-miorelaxant activity in mice, but no significant antagonist effect on clonidine blockade of phenylquinone-induced abdominal constriction. Among test compounds 4a, 4l and 4n showed high antinociceptive effect on the hot-plate test and compound 4e protected from death and convulsion all the electroshocked animals.
Stefancich
G
G
Dipartimento di Scienze, Farmaceutiche, Università di Trieste, Italy.
Artico
M
M
Silvestri
R
R
Pantaleoni
G C
GC
Giorgi
R
R
Palumbo
G
G
D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000494:pharmacology; D001552:Benzazepines / Q000138:chemical synthesis* / Q000494:pharmacology; D016227:Benzoquinones; D003000:Clonidine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D006224:Cricetinae; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009125:Muscle Relaxants, Central / Q000138:chemical synthesis / Q000494:pharmacology; D010146:Pain / Q000139:chemically induced; D011619:Psychotropic Drugs / Q000138:chemical synthesis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared
D000700:Analgesics; D000927:Anticonvulsants; D001552:Benzazepines; D016227:Benzoquinones; D009125:Muscle Relaxants, Central; D011619:Psychotropic Drugs; C029322:phenylbenzoquinone; D003000:Clonidine