Mild traumatic brain injury enhances muscarinic receptor-linked inositol phosphate production in rat hippocampus.
Recent evidence suggests that muscarinic receptors play a role in the hippocampal hypersensitivity to imposed ischemia following mild traumatic brain injury (TBI). In rat hippocampal tissue, carbachol-stimulated inositol phosphate production was found to be enhanced by mild TBI, at 1 h post injury. This finding suggests that mild TBI may result in enhanced coupling between muscarinic receptors and phosphoinositide hydrolysis, which may contribute to post-traumatic hippocampal vulnerability to secondary ischemia.
Delahunty
T M
TM
Division of Neurosurgery, Medical College of Virginia/Virginia Commonwealth University, Richmond 23298.
D000818:Animals; D001930:Brain Injuries / Q000150:complications / Q000503:physiopathology*; D002545:Brain Ischemia / Q000209:etiology / Q000378:metabolism*; D002217:Carbachol; D006624:Hippocampus / Q000098:blood supply / Q000378:metabolism*; D007295:Inositol Phosphates / Q000096:biosynthesis*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011976:Receptors, Muscarinic / Q000502:physiology*
D007295:Inositol Phosphates; D011976:Receptors, Muscarinic; D002217:Carbachol