The effect of malaria infection on 3'-azido-3'-deoxythymidine and paracetamol glucuronidation in rat liver microsomes.
The effect of malaria infection on UDP-glucuronosyltransferase (UDPGT) activity was investigated in rat liver microsomes using 3'-azido-3'-deoxythymidine and paracetamol. The Michaelis-Menten parameters, Km and Vmax were calculated and intrinsic clearance values were estimated for normal and infected livers. The results show that malaria infection alters the activity of UDPGT.
Ismail
S
S
Department of Pharmacology and Therapeutics, University of Liverpool, U.K.
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Edwards
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D000082:Acetaminophen / Q000378:metabolism*; D000818:Animals; D005965:Glucuronates / Q000378:metabolism; D014453:Glucuronosyltransferase / Q000378:metabolism*; D007527:Isoenzymes / Q000378:metabolism*; D007700:Kinetics; D008288:Malaria / Q000201:enzymology / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D010962:Plasmodium berghei; D051381:Rats; D017208:Rats, Wistar; D015215:Zidovudine / Q000378:metabolism*
D005965:Glucuronates; D007527:Isoenzymes; D000082:Acetaminophen; D015215:Zidovudine; D014453:Glucuronosyltransferase