[The clinical efficacy of treating patients with acute pneumonias by using drug and quantum correction of the lipid peroxidation-antioxidant system].
The authors describe the status of lipid peroxidation (diene conjugates and malonic dialdehyde) and the endogenous antioxidant enzyme superoxide dismutase in the course of the treatment of patients with acute focal pneumonia by means of the use of transthoracic intrapulmonary injections of unithiol and autologous ultraviolet blood radiation (AUVBR). Three groups of patients were entered into the study. The first group included 64 patients who were given transthoracic intrapulmonary injections of unithiol, the second group 58 patients who received 5-7 sessions of AUVBR, in the third group, 52 patients were given transthoracic intrapulmonary injections of unithiol coupled with 3-5 sessions of AUVBR. The control group was made up of 40 patients given intravenous unithiol injections in routine therapeutic doses. The results of the treatment evidence that combined correction of lipid peroxidation carried out in the third group patients was most effective. As regards the times, the positive dynamics of lipid peroxidation and superoxide dismutase activity correlated with the clinical, biochemical and x-ray improvement. Therefore the method of correction in question is a pathogenetically based approach, permitting one to enhance the clinical efficacy of the treatment of patients suffering from acute focal pneumonias and to reduce the times of their stay in the hospital by 5-7 days, on the average.
Provotorov
V M
VM
Zizemskaia
E V
EV
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000528:radiation effects; D001769:Blood / Q000528:radiation effects; D001804:Blood Transfusion, Autologous; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000097:blood / Q000628:therapy*; D012074:Remission Induction; D014467:Ultraviolet Therapy; D014494:Unithiol / Q000008:administration & dosage
D000975:Antioxidants; D014494:Unithiol
Klinicheskaia éffektivnost' lecheniia bol'nykh ostrymi pnevmoniiami s primeneniem medikamentoznoĭ i kvantovoĭ korrektsii sistemy perekisnoe-okislenie lipidov--antioksidanty.