Effects of voluntary exercise and/or food restriction on pancreatic tumorigenesis in male rats.
Studies were undertaken to evaluate the effects of caloric restriction on voluntary exercise in a rat model of pancreatic cancer. Suckling male Lewis rats were initiated with 3 doses (30 mg/kg body weight) of the pancreatic carcinogen azaserine. At 28 days of age they were weaned to one of four experimental protocols; namely, sedentary/ad libitum fed, voluntary exercise/ad libitum fed, sedentary/food restricted, and voluntary exercise/food restricted. Voluntary exercise was provided by free access to running wheels fitted with odometers. Food restriction was intended to be mild, at less than 10% reduction of ad libitum intake. Putative pre-neoplastic pancreatic foci were identified microscopically at 4 months post-azaserine treatment. As previously shown, food restriction led to increased wheel activity, but the increased activity could not be maintained beyond the first half of the post-initiation treatment phase. Additionally, the extensive wheel running occurred only when available food was restricted by greater than 10%. Exercise per se had a lesser effect compared to food restriction on pancreatic tumorigenesis.
Giles
T C
TC
Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire.
Roebuck
B D
BD
D000704:Analysis of Variance; D000818:Animals; D001377:Azaserine; D005508:Food Deprivation / Q000502:physiology*; D008297:Male; D010190:Pancreatic Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D010805:Physical Conditioning, Animal; D051381:Rats; D011917:Rats, Inbred Lew; D014836:Volition
D001377:Azaserine