[IL-5-and its receptor--the role of IL-5 in the development of hematopoietic cells in the long-term bone marrow cultures].
IL-5 is a T-cell-derived glycoprotein that acts on B cells and eosinophils to induce their growth and differentiation. We clarified using in vitro long-term bone marrow culture that IL-5 supports the growth and survival of Ly-1+ common progenitor cells which can differentiate into Ly-1+ B cells and Ly-1+ macrophages. The functional IL-5 receptor (IL-5R) consists of alpha and beta heterodimers. The 60 kDa alpha chain binds to IL-5 with low affinity, while the 130 kDa beta chain does not bind with IL-5 by itself, but converts low affinity IL-5R to high affinity IL-5R together with the alpha chain. The beta chain is shared with GM-CSFR and IL-3R.
Katoh
S
S
Department of Immunology, Oklahoma Medical Research Center.
Takatsu
K
K
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D001854:Bone Marrow Cells; D002454:Cell Differentiation; D002455:Cell Division; D002478:Cells, Cultured; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D015848:Interleukin-5 / Q000502:physiology*; D011971:Receptors, Immunologic / Q000502:physiology*; D018123:Receptors, Interleukin; D053649:Receptors, Interleukin-5
D015848:Interleukin-5; D011971:Receptors, Immunologic; D018123:Receptors, Interleukin; D053649:Receptors, Interleukin-5