Role of monoconjugated bilirubin in pathogenesis of gallstones.
In order to explore the substantial role of monoconjugated bilirubin (MCB) in gallstone formation, bile pigment precipitation and hemolytic jaundice, three experimental protocols have been studied, namely, (1) MCB and dietary induced pigment gallstone model, (2) MCB in human gallstone and incubated bile precipitates and (3) MCB in hemolytic jaundice. It was found that doubly increased MCB accounted for 1/3 of the total pigment in lithogenic guinea pig and CDCA plus glycine possessed certain protective effect from gallstone development; MCB was found in human gallstones both in bilirubinate and cholesterol type, and an unknown pigment, possibly an isomer of MCB, was found in black stone. During experimental hemolytic jaundice model preparation, both MCB and UCB were elevated, and MCB was found increased by 10 times, even exceeding the concentration of DCB when the injected bilirubin was about 4 mg/kg of body weight. It is reasonable to consider that MCB as a coprecipitant with UCB and a precursor of UCB played an essential role in the pathogenesis of gallstones.
Li
R
R
Department of Surgery, People's Hospital, Beijing Medical University.
Zhu
X G
XG
Han
J D
JD
Huang
C T
CT
D000818:Animals; D001646:Bile / Q000737:chemistry; D001663:Bilirubin / Q000032:analysis / Q000502:physiology*; D002769:Cholelithiasis / Q000737:chemistry / Q000209:etiology*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004285:Dogs; D006168:Guinea Pigs; D006801:Humans; D008297:Male
D001663:Bilirubin