Congenital adrenal hyperplasia: experience at Calcutta.
Eight patients (7 females, 1 male) with congenital adrenal hyperplasia (CAH), were seen over a 24-month period beginning from March 1988. Seven patients had 21 hydroxylase (21-OH) deficiency while one had 11 beta hydroxylase deficiency. Of the 7 patients with 21-OH deficiency, 3 were of the salt losing (SL-CAH), and 4 were of the non-salt losing (NSL-CAH) type. The patients with NSL-CAH were diagnosed by their elevated 17-hydroxyprogesterone (17-OHP) levels. The 3 cases with SL-CAH were diagnosed on the basis of ambiguous external genitalia, typical electrolyte picture, normal female internal genitalia, sex chromatin and response to steroids. In one patient post-ACTH 17 OHP was alter measured. All 3 patients with SL-CAH were assigned the male sex. Sex reassignment was advised for two children; one accepted the advice and the child is doing well; one family did not accept sex reassignment and the child died. One patient died due to non-availability of fludrocortisone. Six patients are under follow-up. All are doing well except one patient with NSL-CAH who started treatment late. We conclude that a high index of suspicion, early diagnosis and meticulous patient education are the key features of successful management of CAH in India.
Chatterjee
S
S
Park Children's Centre for Treatment and Research, Calcutta.
Chatterjee
S K
SK
D000312:Adrenal Hyperplasia, Congenital / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D001623:Betamethasone / Q000008:administration & dosage / Q000627:therapeutic use; D002896:Chromosomes, Human, Pair 6; D002987:Clitoris / Q000002:abnormalities / Q000601:surgery; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006908:Hydroxyprogesterones / Q000032:analysis; D007194:India; D007223:Infant; D008297:Male; D012727:Sex Characteristics; D012729:Sex Chromosome Aberrations / Q000235:genetics; D013255:Steroid 21-Hydroxylase / Q000032:analysis
D006908:Hydroxyprogesterones; D003907:Dexamethasone; D001623:Betamethasone; D013255:Steroid 21-Hydroxylase