Genetic control of resistance to enterotoxigenic Escherichia coli in infant mice.
DBA/2 and CBA infant mice orally challenged with bovine enterotoxigenic Escherichia coli (ETEC) strain B80 presented resistance and susceptibility respectively, as measured by mortality rates 6 days after inoculation. Serum antibodies agglutinating ETEC strain B80 had very low titers in both mouse strains. Mendelian analysis of resistance on F1 and on segregating back-crosses showed that resistance is genetic and dominant. Dominance may be explained either by a mixed control with an overdominant major gene or by a polygenic control with a large heterosis effect.
Duchet-Suchaux
M
M
Pathologie Infectieuse et Immunologie, Institut National de la Recherche Agronomique, Nouzilly, France.
Menanteau
P
P
Le Roux
H
H
Elsen
J M
JM
Lechopier
P
P
D000818:Animals; D000831:Animals, Newborn; D003433:Crosses, Genetic; D004926:Escherichia coli / Q000276:immunology; D004927:Escherichia coli Infections / Q000235:genetics / Q000276:immunology*; D007113:Immunity, Innate / Q000235:genetics; D051379:Mice; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA