Sex and dietary fat modulate hepatic prostaglandin F2 alpha in F344/N rats.
The study was designed to determine whether sex and fat calories altered hepatic prostaglandin (PG) F2 alpha status; a factor which may reflect susceptibility to cancer development. For 4 weeks, groups of 8 male and 8 female F344/N rats were fed diets with 9% of energy (en%) from linoleate and 15.5, 20, 30 or 40 en% fat. Females had greater hepatic stearate, arachidonate and PGF2 alpha whereas males had greater hepatic myristate, palmitate and oleate. Females also had greater plasma stearate levels. Greater hepatic arachidonate may have stimulated PG production in females. Hepatic oleate increased and hepatic palmitate decreased with increasing en% fat (p < 0.05). Hepatic stearate was greater and hepatic linoleate less when 40 en% fat was fed compared with other levels of dietary fat (p < 0.05). Plasma oleate was greater at 30 or 40 en% fat than at lower levels of fat, whereas plasma linoleate was less at 40 en% than at 15.5% en% fat. The ability of a 30 en% fat diet, containing equal proportions of linoleate and oleate, to suppress hepatic PG production may be related to the effects of dietary fat content and composition on plasma fatty acid profiles. Because suppressed PG production has been linked with suppression of cancer development, dietary recommendations to consume 30 en% fat with a P:M ratio of 1:1 may be cancer-protective.
Chen
H W
HW
Department of Food Science and Human Nutrition, Iowa State University, Ames 50010.
Duitsman
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P
Cook
L
L
Hendrich
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S
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004041:Dietary Fats / Q000494:pharmacology*; D015237:Dinoprost / Q000378:metabolism*; D004198:Disease Susceptibility / Q000378:metabolism; D002149:Energy Intake; D005227:Fatty Acids / Q000032:analysis; D005260:Female; D008099:Liver / Q000378:metabolism*; D008114:Liver Neoplasms, Experimental / Q000209:etiology / Q000517:prevention & control; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344 / Q000378:metabolism*; D012727:Sex Characteristics
D004041:Dietary Fats; D005227:Fatty Acids; D015237:Dinoprost