title: An outbreak of typhoid due to multidrug resistant Salmonella typhi in Pondicherry.
abstract: An outbreak of typhoid due to multi-drug resistant Salmonella typhi is reported from Pondicherry, India. While the average prevalence of drug resistant strains in 1980-1988 had been 11.7%, it increased to 52% in 1989-1990. The majority of strains (80.8%) were resistant to chloramphenicol, streptomycin, tetracycline and ampicillin; 40% were resistant to co-trimoxazole. Minimum inhibitory concentrations to 8 antibiotics for 17 representative strains were more than 10-fold greater than those of 13 sensitive strains. The multi-resistance was shown to be plasmid mediated in direct conjugation experiments and the strains belonged to Viphage type O, biotype II.
authors.affiliation: Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
authors.forename: R S
authors.initials: RS
authors.lastname: Rao
authors.forename: S K
authors.initials: SK
authors.lastname: Amarnath
authors.forename: S
authors.initials: S
authors.lastname: Sujatha
mesh_terms: D002702:Chloramphenicol Resistance; D004196:Disease Outbreaks; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D012485:Salmonella typhi / Q000187:drug effects; D014435:Typhoid Fever / Q000188:drug therapy* / Q000453:epidemiology*