title: Effect of a regional increase in alveolar pressure on pulmonary blood flow.
abstract: We examined whether wedging a catheter (0.5 cm OD) into a subsegmental airway in dog (n = 6) or pig lungs (n = 5) and increasing pressure in the distal lung segment affected pulmonary blood flow. Dogs and pigs were anesthetized and studied in the prone position. Pulmonary blood flow was measured by injecting radiolabeled microspheres (15 microns diam) into the right atrium when airway pressure (Pao) was 0 cmH2O and pressure in the segment distal to the wedged catheter (Ps) was 0, 5, or 15 cmH2O and when Pao = Ps = 15 cmH2O. The lungs were excised, air-dried, and sectioned. Blood flow per gram dry weight normalized to cardiac output to the right or left lung, as appropriate, was calculated for the test segment, a control segment in the opposite lung corresponding anatomically to the test segment, the remainder of the lung containing the test segment (test lung), and the remainder of the lung containing the control segment (control lung). The presence of the catheter reduced blood flow in the test segment compared with that in the control segment and in the test lung. Blood flow was not affected by increasing pressure in the test segment. We conclude that, in studies designed to measure collateral ventilation in dog lungs, the presence of the wedged catheter is likely to have a greater effect on blood flow than the increase in pressure associated with measuring collateral airway resistance.
authors.affiliation: Department of Veterinary Physiology and Pharmacology, Ohio State University, Columbus 43210-1092.
authors.forename: L E
authors.initials: LE
authors.lastname: Olson
authors.forename: R L
authors.initials: RL
authors.lastname: Wardle
mesh_terms: D000818:Animals; D001784:Blood Gas Analysis; D002302:Cardiac Output / Q000502:physiology; D004285:Dogs; D008863:Microspheres; D009929:Organ Size / Q000502:physiology; D010101:Oxygen Consumption / Q000502:physiology; D011650:Pulmonary Alveoli / Q000502:physiology*; D011652:Pulmonary Circulation / Q000502:physiology*; D013045:Species Specificity; D013552:Swine