[Effect of habenular nucleus in 5-HT ascending pressor pathways].
The blood pressure was elevated by the electric stimulation of dorsal raphe nucleus in rats. Microinjection of 5-HT (6 micrograms, 3 micrograms) into habenular nucleus induced pressor effect too, but the heart rate was not much changed. Microinjection of procaine hydrochloride (300 micrograms.microliters-1) into both sides of habenular nuclei, the pressor effect induced by stimulation of dorsal raphe nucleus was alleviated obviously (85% blockade). The data suggested that habenular nucleus participates in the pressor effect caused by the excitation of dorsal raphe nucleus, and 5-HT may be one of the neurotransmitters in the action of habenular nucleus participating in cardiovascular regulatory function.
Zhang
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XY
Department of Physiology, Norman Bethune University of Medical Sciences, Changchun, China.
Wang
S
S
D000818:Animals; D001794:Blood Pressure; D004558:Electric Stimulation; D005260:Female; D006339:Heart Rate; D008297:Male; D011903:Raphe Nuclei / Q000502:physiology; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*; D013787:Thalamic Nuclei / Q000187:drug effects / Q000502:physiology*; D015854:Up-Regulation
D012701:Serotonin