[Synthesis and pharmacology of structural analogs of tienilic acids].
Three structural analogs of tienilic acid were synthetized and evaluated for their diuretic activity in the rat. Two compounds are alpha substituted tienilic acid derivatives by an alkylated group. The third one is a conformationally restricted derivative through a cyclization process. All compounds fall to increase the urinary flow in the pharmacological assay.
de Saqui-Sannes
G
G
Département de Chimie Pharmaceutique, Faculté de Pharmacie, Toulouse.
Baziard-Mouysset
G
G
Payard
M
M
Tronche
P
P
Auriac
A
A
Roux
G
G
D000818:Animals; D004232:Diuretics / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013989:Ticrynafen / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology
D004232:Diuretics; D013989:Ticrynafen
Synthèse et approche pharmacologique d'analogues structuraux de l'acide tiénilique.