Influence of radiation treatment on serum transferrin and tumor necrosis factor-alpha.
This study deals with the effect of radiation treatment (RT) on serum transferrin and tumor necrosis factor-alpha (TNF-alpha) in patients with malignant tumors. In 21 patients who received 36-60 Gy in 20 to 30 sessions of RT, serum transferrin and TNF-alpha were determined pre-RT, after 10 to 15 sessions (middle of RT) and after 20 to 30 sessions (end of RT). The values of serum transferrin pre-RT were significantly higher than those in the middle and at the end of RT (p < 0.001). The values of TNF-alpha were increased by RT and were significantly higher at the end of RT as compared to the pre-RT values (p < 0.05). The values of serum transferrin and TNF-alpha show a tendency to negative correlation, either as a whole or separately pre- and under-RT. However, no correlation was statistically significant.
Agroyannis
B
B
Aretaieon Hospital University of Athens, Department of Radiotherapy, Greece.
Kouvaris
J
J
Tzanatos
H
H
Chondros
K
K
Stringou
E
E
Damatopoulou
A
A
Dalamangas
A
A
Koutsikos
D
D
Papavasiliou
C
C
D000368:Aged; D006801:Humans; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000532:radiotherapy*; D014168:Transferrin / Q000378:metabolism / Q000528:radiation effects*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism / Q000528:radiation effects*
D014168:Transferrin; D014409:Tumor Necrosis Factor-alpha