[The significance of beta 2-microglobulin for the diagnosis of preleukemic states in workers of the chemical industry].
A study is presented of 89 workers contacting with benzene and its derivatives and 98 workers without contacts with chemical substances. Radioimmunological assay of peripheral blood B2-microglobulin was carried out. Persons with a length of work over 10 years contacting with anilin and its derivatives showed a marked increase of B2-microglobulin in the blood serum as well a marked reduction of leucocyte number. It is considered that leucopenia with granulocytopenia and marked increase of B2-microglobulin is regarded as a preleucosis state.
Mironova
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EV
D000814:Aniline Compounds / Q000009:adverse effects; D002617:Chemical Industry; D005260:Female; D006801:Humans; D007970:Leukopenia / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis; D008297:Male; D009784:Occupational Diseases / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis*; D016273:Occupational Exposure / Q000009:adverse effects; D011289:Preleukemia / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis*; D011863:Radioimmunoassay / Q000379:methods; D014455:Ukraine; D001613:beta 2-Microglobulin / Q000032:analysis*
D000814:Aniline Compounds; D001613:beta 2-Microglobulin
Znachenie beta 2-mikroglobulina dlia diagnostiki predleĭkoznykh sostoianiĭ u rabochikh khimicheskoĭ promyshlennosti.