Interaction of malarial infection and glucose-6-phosphate dehydrogenase deficiency in Muria gonds of district Bastar, central India.
Muria gond tribals (n = 473) from district Bastar, central India, an area known to be hyperendemic for malaria, were investigated for malarial infection and glucose-6-phosphate dehydrogenase deficiency. The frequency of G-6-PD deficiency was 21.3% among male subjects and 3.7% among females. Assay of malarial antibodies showed that seropositivity as well as the level of antibodies was significantly higher in male subjects with normal enzyme levels as compared with males G-6-PD deficiency. Females with normal G-6-PD enzyme levels too had higher seropositivity as well as level of antibodies against malaria as compared with females having G-6-PD deficiency. This suggests that G-6-PD deficiency correlates with a higher degree of resistance.
Thakur
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Department of Pediatrics, All India Institute of Medical Sciences, New Delhi.
Verma
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IC
D000913:Antibodies, Protozoan / Q000032:analysis; D005260:Female; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007194:India / Q000453:epidemiology; D016778:Malaria, Falciparum / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D016780:Malaria, Vivax / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D008297:Male; D015995:Prevalence
D000913:Antibodies, Protozoan