The role of alpha 1-proteinase inhibitor in semisoluble glucan induced resistance to hemorrhage.
The present study was undertaken to evaluate the mechanism of protective effect of semisoluble beta-1,3-carboxymethylglucan (CMG) during acute massive hemorrhage. CBA mice were injected i.v. with glucan (25 mg/kg) 24 h prior to hemorrhage (50% of blood circulating volume). Survival data indicated that glucan increased survival compared with control. However, alpha 1-proteinase inhibitor activity in serum have been even decreased 24 h after glucan administration. Moreover enhancement of active oxygen form production and leakage of cytosol and lysosomal enzymes after CMG application were noted.
Vereschagin
E I
EI
Department of Cellular Biochemistry and Physiology, Academy of Medical Sciences of USSR, Novosibirsk.
Korolenko
T A
TA
Arkhipov
S A
SA
D000135:Acid Phosphatase / Q000097:blood; D000818:Animals; D005936:Glucans / Q000494:pharmacology* / Q000627:therapeutic use; D006470:Hemorrhage / Q000097:blood / Q000503:physiopathology*; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D000515:alpha 1-Antitrypsin / Q000378:metabolism*; D001616:beta-Galactosidase / Q000097:blood; D047071:beta-Glucans
D005936:Glucans; D000515:alpha 1-Antitrypsin; D047071:beta-Glucans; C029933:carboxymethyl-beta-1,3-glucan; D000135:Acid Phosphatase; D001616:beta-Galactosidase