title: [Achievements and prospects of the directed search for antiviral agents in the nucleoside series and their derivatives].
abstract: Recent advances of antiviral drug design among nucleosides and their derivatives have been summarized. The first chapter deals with the history of nucleic acids components and further developments in this area. Next part discusses the mechanism of action of biologically active nucleosides: 2',3'-dideoxynucleosides, acyclic analogues, phosphonate derivatives and nucleoside antibiotics. The third chapter describes planning of complicated synthesis of nucleoside analogues from branched-chain sugars and stereo-specific formation of glycosidic bond upon synthesis of ribonucleoside and 2'-deoxyribonucleoside. The last part outlines further perspectives, i. e. preparation of antiviral compounds and use of nucleoside analogues in oligonucleotide synthesis.
authors.forename: S N
authors.initials: SN
authors.lastname: Mikhaĭlov
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D009705:Nucleosides / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides
vernacular_title: Dostizheniia i perspektivy napravlennogo poiska antivirusnykh veshchestv v riadu nukleozidov i ikh porizvodnykh.