Binding of T cell receptor to major histocompatibility complex class II-peptide complexes at the single-cell level results in the induction of antigen unresponsiveness (anergy).
Using dispersion cultures performed in semi-solid medium we demonstrate here that the interaction of T cell antigen receptor molecules with Ia-peptide complexes on the same cell surface results in T cell activation, without the production of lymphokines. This recognition of antigen at the single-cell level, induced a state of anergy which was not due to a decrease of surface T cell antigen receptor/CD3 complexes. The induction of anergy by peptide could not be prevented by the addition of various co-stimulatory signals, including antibodies to CD28, or CD2, high doses of interleukin-2 or phorbol ester.
Celis
E
E
First Department of Internal Medicine, Kochi Medical School.
Saibara
T
T
D000595:Amino Acid Sequence; D000938:Antigen-Presenting Cells / Q000502:physiology; D002450:Cell Communication; D000949:Histocompatibility Antigens Class II / Q000378:metabolism*; D006801:Humans; D007108:Immune Tolerance; D008213:Lymphocyte Activation; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000276:immunology / Q000378:metabolism*; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology*
D000949:Histocompatibility Antigens Class II; D010446:Peptide Fragments; D011948:Receptors, Antigen, T-Cell