title: Evaluation of Telazol-xylazine as an anesthetic combination for use in Syrian hamsters.
abstract: The availability of safe parenteral anesthetics for use in Syrian hamsters is limited. We evaluated the effects of Telazol-xylazine (TZX) combinations with respect to anesthetic efficacy and potential for tissue damage. Two dose levels of the combination were administered by both the intraperitoneal (IP) and intramuscular (IM) routes. TZX by the IM route failed to consistently produce anesthesia and caused gross and histopathologic muscle lesions. IP administration of 20 mg/kg Telazol combined with 10 mg/kg xylazine was adequate for restraint purposes. IP administration of 30 mg/kg Telazol combined with 10 mg/kg xylazine produced a safe, reliable level of surgical anesthesia without evidence of gross or histopathologic lesions. There was no nephrotoxicity at either concentration of the anesthetic. A dose level of TZX that provides safe parenteral anesthesia in Syrian hamsters was determined.
authors.affiliation: Comparative Medicine Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709.
authors.forename: D B
authors.initials: DB
authors.lastname: Forsythe
authors.forename: A J
authors.initials: AJ
authors.lastname: Payton
authors.forename: D
authors.initials: D
authors.lastname: Dixon
authors.forename: P H
authors.initials: PH
authors.lastname: Myers
authors.forename: J A
authors.initials: JA
authors.lastname: Clark
authors.forename: J R
authors.initials: JR
authors.lastname: Snipe
mesh_terms: D000768:Anesthesia, General / Q000662:veterinary*; D000818:Animals; D006224:Cricetinae; D004338:Drug Combinations; D005260:Female; D007273:Injections, Intramuscular / Q000662:veterinary; D007274:Injections, Intraperitoneal / Q000662:veterinary; D008647:Mesocricetus; D009135:Muscular Diseases / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary; D012119:Respiration / Q000187:drug effects; D012376:Rodent Diseases / Q000139:chemically induced / Q000473:pathology; D013992:Tiletamine / Q000008:administration & dosage* / Q000633:toxicity; D014991:Xylazine / Q000008:administration & dosage* / Q000633:toxicity; D015041:Zolazepam / Q000008:administration & dosage* / Q000633:toxicity
chemical_list: D004338:Drug Combinations; C006131:tiletamine, zolazepam drug combination; D014991:Xylazine; D013992:Tiletamine; D015041:Zolazepam