Neutralizing antibodies against HTLV-I in HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients and asymptomatic carriers.
We tested serum specimens from patients with HAM/TSP and asymptomatic HTLV-I carriers from endemic areas of Japan, Jamaica, Colombia, and Chile for neutralizing antibodies against HTLV-I. The data suggest a trend for neutralizing activity to be found more frequently in the sera from HAM/TSP patients than in sera from asymptomatic carriers. The result of this study emphasizes the importance of determining biologic properties of the envelope glycoprotein of HTLV-I.
Minagawa
H
H
Department of Virology, Kyushu University, Fukuoka, Japan.
Yoshida
T
T
Itoyama
Y
Y
Mora
C A
CA
Albert
P
P
Mori
R
R
D002353:Carrier State / Q000276:immunology; D002460:Cell Line; D004797:Enzyme-Linked Immunosorbent Assay; D015481:HTLV-I Antibodies / Q000097:blood*; D015490:HTLV-I Infections / Q000276:immunology; D006801:Humans; D015493:Paraparesis, Tropical Spastic / Q000276:immunology*
D015481:HTLV-I Antibodies