T cell recognition of hepatitis B envelope proteins.
We have studied the T-cell processing pathways of Hepatitis B antigens and the role of specific B lymphocytes. It could be shown that some form of processing by specific B cells is required for class I CTLs. This mechanism differs from class II endosomal processing. In addition, it could be shown that lysis of HBsAg-specific B cells may be partly responsible for chronic HBV carrier states.
Barnaba
V
V
Fondazione Andrea Cesalpino, I Clinica Medica, Università La Sapienza, Roma, Italy.
Franco
A
A
Paroli
M
M
Benvenuto
R
R
Santilio
I
I
Balsano
F
F
D001402:B-Lymphocytes / Q000276:immunology; D002353:Carrier State / Q000276:immunology; D006509:Hepatitis B / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology*; D014759:Viral Envelope Proteins / Q000276:immunology*
D006514:Hepatitis B Surface Antigens; D014759:Viral Envelope Proteins