[The effect of clofelin on uterine contractile activity (experimental and clinical research)].
Pregnant rat experiments have revealed a pronounced and prolonged naloxone-irreversible depriming effect of clofelin, 0.05 and 0.5 mg/kg, on the frequency and amplitude of myometrial biopotentials, which was eliminated with phenoxybenzamine. In clinical testing, clofelin in therapeutical doses showed a marked tocolytic effect in threatened abortion at 18-34-week gestation. The agent in the same doses normalized blood pressure in hypertensive pregnants, without having a negative action on the fetus.
Khushvakhtova
E Kh
EKh
Arzhanova
N O
NO
Zaĭtseva
A A
AA
D000033:Abortion, Threatened / Q000188:drug therapy / Q000503:physiopathology; D000293:Adolescent; D000328:Adult; D000818:Animals; D003000:Clonidine / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004347:Drug Interactions; D005260:Female; D006801:Humans; D009129:Muscle Tonus / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D015149:Tocolytic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D014590:Uterine Contraction / Q000187:drug effects*
D015149:Tocolytic Agents; D003000:Clonidine
Vliianie klofelina na sokratitel'niu aktivnost' matki (éksperimental'no-klinicheskoe issledovanie).