[Clonorchiasis in the People's Republic of Vietnam. 2. The clinico-parasitological examination of a focus and a trial of prazinquantel treatment].
Examinations of 1599 residents of a polyinvasion focus at a seaside province Ha Nam Nin, Vietnam, have revealed clonorchiasis in approximately 13.9% of the examinees; in subjects aged over 30 this value was 29.3%. Factors conducive to a lower incidence of clonorchiasis were detected, among them a moderate intensity of the invasion: the mean arithmetic was 1419 +/- 306 eggs/g, the mean geometric 673 egg/g, as shown by the Kato-Kats' technique. Analysis of five therapeutic schemes used in clonorchiasis, making use of chloxilin, medamin or praziquantel, has demonstrated a low efficacy of all of them. Praziquantel therapy in a daily dose of 25 mg/kg for 2 days was found the most effective (52%), being conducive to a reduction of the invasion intensity by at least 90%. Such therapy was associated with a high incidence of side effects (91.2%), this ruling out a higher dosage.
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D000328:Adult; D000818:Animals; D000980:Antiplatyhelmintic Agents / Q000627:therapeutic use; D001562:Benzimidazoles / Q000627:therapeutic use; D002219:Carbamates; D003003:Clonorchiasis / Q000188:drug therapy / Q000469:parasitology*; D003004:Clonorchis sinensis; D004197:Disease Reservoirs; D004341:Drug Evaluation; D005243:Feces / Q000469:parasitology; D006801:Humans; D010270:Parasite Egg Count; D011223:Praziquantel / Q000009:adverse effects / Q000627:therapeutic use*; D012424:Rural Population; D014744:Vietnam; D014992:Xylenes / Q000627:therapeutic use
D000980:Antiplatyhelmintic Agents; D001562:Benzimidazoles; D002219:Carbamates; D014992:Xylenes; D011223:Praziquantel; C000294:hexachloro-4-xylene; C006698:carbendazim
Klonorkhoz v SRV. Soobshchenie 2. Kliniko-parazitologicheskoe obsledovanie ochaga i opyt lecheniia prazikvantelem.