[Role of histamine receptors of mouse and guinea pig peritoneal leukocytes in the pathogenetic effect of Yersinia pestis adenylate cyclase].
The effect of purified preparation of adenylate cyclase isolated from Y. pestis on peritoneal leukocytes of white mice and guinea pigs was investigated. Y. pestis adenylate cyclase was shown to accomplish its pathogenic action via histamine-specific receptors on the surface of eukaryotic cells. The involvement of H1 and H2 histamine receptors on target cells in the adenylate cyclase action leading to development of plague infection is discussed.
Mishan'kin
B N
BN
Aseeva
L E
LE
Shevchenko
L A
LA
Rublev
B D
BD
D000262:Adenylyl Cyclases / Q000502:physiology*; D000818:Animals; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D006633:Histamine Antagonists / Q000494:pharmacology; D007962:Leukocytes / Q000276:immunology*; D008163:Luminescent Measurements; D051379:Mice; D010537:Peritoneum; D011968:Receptors, Histamine / Q000187:drug effects / Q000502:physiology*; D012397:Rosette Formation; D015010:Yersinia pestis / Q000201:enzymology* / Q000472:pathogenicity
D006633:Histamine Antagonists; D011968:Receptors, Histamine; D006632:Histamine; D000262:Adenylyl Cyclases
Rol' gistaminovykh retseptorov peritoneal'nykh leĭkotsitov mysheĭ i morskikh svinok v realizatsii patogeneticheskogo deĭstviia adenilattsiklazy chumnogo mikroba.