[Pancytopenia as a complication of the treatment of toxoplasmosis].
Therapeutical doses of pyrimethamine are very close to toxic ones. Pyrimethamine is widely used in toxoplasmosis therapy. Hematological complications following pyrimethamine administration were seen in 4 patients treated for toxoplasmosis at our hospital in the last year. Pancytopenic syndrome was diagnosed in all four cases. Three patients recovered completely whereas ITP is persisting in one patient.
Kachel
L
L
Kliniki Hematologii Slaskiej AM, Katowicach.
Krawczyk-Kuliś
M
M
Hołowiecki
J
J
D000328:Adult; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D010198:Pancytopenia / Q000139:chemically induced* / Q000628:therapy; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000139:chemically induced* / Q000628:therapy; D015597:Pregnancy Complications, Parasitic / Q000097:blood / Q000188:drug therapy*; D011739:Pyrimethamine / Q000008:administration & dosage / Q000009:adverse effects*; D014123:Toxoplasmosis / Q000097:blood / Q000150:complications / Q000188:drug therapy*
D011739:Pyrimethamine
Pancytopenia jako powikłanie leczenia toksoplazmozy.