title: Enzymes as molecular automata: a reflection on some numerical and philosophical aspects of the hypothesis.
abstract: Enzymes, by means of their properties of specific recognition and allosteric modulation, are able to integrate many separate processes into systemic units with coherent functions; in a sense, they have to be considered as the true organizers of the cytoplasmic processes. In this respect, the present article describes a simple model, based on binary variables and automata theory, which simulates the basic regulatory performance of the modulated enzyme. The model admits a variety of modifications and improvements; it also suggests some original lines of thought on which to reflect about the organization and collective phenomena of the networks of enzymes. In discussing the connection of this 'molecular automata' hypothesis with other areas of present-day theoretical biology, a fertile panorama of initiatives appear. A special partnership between Information Science (computation) and Biology is developing.
authors.affiliation: Dept. Genetica Molecular, Investigacion y Desarrollo CSIC, Barcelona, Spain.
authors.forename: P C
authors.initials: PC
authors.lastname: Marijuán
authors.forename: J
authors.initials: J
authors.lastname: Westley
mesh_terms: D002451:Cell Compartmentation; D002477:Cells / Q000201:enzymology; D004798:Enzymes / Q000378:metabolism*; D007700:Kinetics; D008954:Models, Biological; D015233:Models, Statistical
chemical_list: D004798:Enzymes