title: The use of exercise technetium-99m 2-methoxy-isobutyl-isonitrile (99mTc-Sestamibi) perfusion scanning in the detection of acute rejection after cardiac transplantation.
abstract: Acute cardiac rejection remains an important cause of death during the first year following cardiac transplantation. Right ventricular biopsies at regular intervals are the main method of detecting rejection, although it is invasive. Unfortunately, non-invasive methods of detecting rejection have not proved reliable enough to replace cardiac biopsies. We assessed the usefulness of technetium-99m 2-methoxy-isobutyl-isonitrile (99mTc-Sestamibi) perfusion scanning in detecting acute rejection in 12 human orthotopic cardiac transplant recipients. Rest and exercise studies and right ventricular biopsies were performed on two occasions. Isotopic evidence of rejection was defined as a perfusion abnormality on either the resting or exercise studies. 99mTc-Sestamibi studies successfully identified acute rejection in 8 of 11 rejection episodes (p less than 0.04). The calculated sensitivity and specificity of 99mTc-Sestamibi scanning were both 72%. Perfusion scanning with 99mTc-Sestamibi may be useful in the diagnosis of acute rejection in cardiac transplant recipients.
authors.affiliation: Transplant Unit, Papworth Hospital, Huntington Cambridge, United Kingdom.
authors.forename: P A
authors.initials: PA
authors.lastname: Mullins
authors.forename: P M
authors.initials: PM
authors.lastname: Schofield
authors.forename: J
authors.initials: J
authors.lastname: Dunning
authors.forename: J
authors.initials: J
authors.lastname: Scott
authors.forename: D
authors.initials: D
authors.lastname: Aravot
authors.forename: S
authors.initials: S
authors.lastname: Large
authors.forename: N
authors.initials: N
authors.lastname: Cary
authors.forename: J
authors.initials: J
authors.lastname: Wallwork
authors.forename: D
authors.initials: D
authors.lastname: Stone
mesh_terms: D000328:Adult; D005080:Exercise Test; D006084:Graft Rejection / Q000000981:diagnostic imaging*; D016027:Heart Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009570:Nitriles; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D017256:Technetium Tc 99m Sestamibi
chemical_list: D009570:Nitriles; D015609:Organotechnetium Compounds; D017256:Technetium Tc 99m Sestamibi