Assay of antibodies to hepatitis C virus protein C100-3 in blood donors from northern Germany.
The prevalence of anti-C100-3 increases with age from 0.41% to 1.26%. It is more frequent in donors with elevated ALT (4.5%). Most ALT elevations, however, are not related to anti-C100-3. Low EIA signals (< 3 x cutoff) are often non-specific. The cutoff value should be 2.5 times higher. High EIA signals correlate with ALT elevations.
Caspari
G
G
German Red Cross Blood Transfusion Service of Lower Saxony, Springe.
Beyer
H J
HJ
Gerlich
W H
WH
Schmitt
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D000956:Antigens, Viral; D001782:Blood Donors; D005260:Female; D005858:Germany / Q000453:epidemiology; D006508:Hepatitis Antibodies / Q000097:blood*; D006526:Hepatitis C / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011933:Reagent Kits, Diagnostic; D017361:Viral Nonstructural Proteins; D014764:Viral Proteins / Q000276:immunology*
D000956:Antigens, Viral; C064544:C100 protein, hepatitis C virus; D006508:Hepatitis Antibodies; D011933:Reagent Kits, Diagnostic; D017361:Viral Nonstructural Proteins; D014764:Viral Proteins; D000410:Alanine Transaminase