Improvement of fog and exercise-induced bronchoconstriction after local and subcutaneous immunotherapy in mite asthma.
We compared the changes of non-specific bronchial hyperreactivity to methacholine, UNDW and exercise in 2 groups of patients with mite asthma treated with local immunotherapy (LIT group: 12 patients) and subcutaneous immunotherapy (SIT group: 8 patients) for 1 year. Bronchial challenges were done 1 week before the beginning and 1 week after the end of 1 year of treatment. The results showed a reduction of bronchial hyperreactivity to methacholine in the LIT group (PD 20FEV1 before: 223 +/- 193, after: 434 +/- 548) but not in the SIT group (PD 20FEV1: before: 143 +/- 188, after: 125 +/- 121) but the difference was not statistically significant. Exercise-induced bronchoconstriction completely disappeared in all the patients of LIT group (8/8) although only in 2 out of 4 patients of SIT group. Water-induced bronchoconstriction improved in 66% of LIT group (4/6) compared with none of SIT group (0/4). We conclude that, with the protocol of the present study, LIT is able to improve, more than SIT, non-specific bronchial hyperreactivity evaluated with osmotic stimuli as exercise and UNDW but not with pharmacologic stimuli as methacholine.
Corbetta
L
L
Servizio di Fisiopatologia Respiratoria, Ospedale Civile SS. Giovanni e Paolo, Venice, Italy.
Pesiri
P
P
Ferro
G
G
Mander
A
A
D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000336:Aerosols; D000485:Allergens / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D039741:Antigens, Dermatophagoides; D001249:Asthma / Q000503:physiopathology*; D001250:Asthma, Exercise-Induced / Q000628:therapy*; D016535:Bronchial Hyperreactivity / Q000209:etiology / Q000628:therapy*; D001985:Bronchial Provocation Tests; D002648:Child; D003888:Desensitization, Immunologic / Q000379:methods*; D005080:Exercise Test; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D016210:Methacholine Chloride; D008925:Mites / Q000276:immunology*; D014887:Weather
D000336:Aerosols; D000485:Allergens; D039741:Antigens, Dermatophagoides; D016210:Methacholine Chloride