Bone induction by composites of bioresorbable carriers and demineralized bone in rats: a comparative study of fibrin-collagen paste, fibrin sealant, and polyorthoester with gentamicin.
Host tissue response and heterotopic osteoinduction by composites of demineralized bone matrix and three different substances used as bioresorbable carriers implanted in the abdominal muscles were evaluated by strontium 85 uptake and histology 4 weeks postoperatively in 60 male Wistar rats. Both fibrin-collagen paste and fibrin sealant inhibited bone induction and produced a chronic inflammation; part of the fibrin-collagen paste was still present at 4 weeks. Polyorthoester with gentamicin was almost completely absorbed, induced minimal tissue reaction, and did not inhibit osteoinduction.
Pinholt
E M
EM
Department of Oral and Maxillofacial Surgery, School of Dentistry, University of Copenhagen, Denmark.
Solheim
E
E
Bang
G
G
Sudmann
E
E
D000042:Absorption; D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D001857:Bone Matrix / Q000502:physiology*; D003094:Collagen / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005337:Fibrin / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D005839:Gentamicins / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D015726:Giant Cells / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D008297:Male; D010012:Osteogenesis / Q000187:drug effects*; D011091:Polyesters / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D019736:Prostheses and Implants; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000473:pathology
D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D015718:Fibrin Tissue Adhesive; D005839:Gentamicins; D011091:Polyesters; C045986:Alzamer; D005337:Fibrin; D003094:Collagen