title: Silicone implants and systemic immunological disease: review of the literature and preliminary results.
abstract: Silicone has been utilized as an implant in reconstructive surgery. For years, silicone has been considered to be biologically inert and essentially harmless. Several studies and case reports show that female patients treated with silicone implants developed a systemic disease associated with immunological abnormalities. Removal of the silicone implants was associated with recovery and resolution of the immune abnormalities. Recently, specific antibodies to silicone have been isolated in children with silicone implants. Additionally, immunological abnormalities and high incidence of systemic progressive sclerosis in patients with silicone implants or injections further support the notion that silicone is not biologically inert, and can cause a syndrome of a systemic disease and immunological abnormalities. The specific mechanisms and duration of the latency period is not yet fully understood.
authors.forename: N
authors.initials: N
authors.lastname: Brautbar
authors.forename: A
authors.initials: A
authors.lastname: Vojdani
authors.forename: A W
authors.initials: AW
authors.lastname: Campbell
mesh_terms: D000328:Adult; D000906:Antibodies / Q000097:blood; D003240:Connective Tissue Diseases / Q000209:etiology; D005260:Female; D015745:Granuloma, Foreign-Body / Q000209:etiology*; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000209:etiology; D008206:Lymphatic Diseases / Q000209:etiology; D008875:Middle Aged; D019736:Prostheses and Implants / Q000009:adverse effects*; D012595:Scleroderma, Systemic / Q000209:etiology*; D012828:Silicones / Q000009:adverse effects*
chemical_list: D000906:Antibodies; D012828:Silicones