Effect of lysophosphatidylcholine on renal hemodynamics and excretory function in anesthetized rats.
The effect of myristoyl-lysophosphatidylcholine (myristoyl-LPC) on renal hemodynamics, electrolyte and water excretion was examined over a 90 min period in sodium pentobarbital anesthetized male Sprague Dawley rats. Intravenous infusion of myristoyl-LPC at 13 +/- 3 pmol/min resulted in a small fall in systemic blood pressure, a 13% decrease in renal plasma flow without significantly altering glomerular filtration rate and produced a slightly greater excretion of sodium and water than vehicle controls. These results suggest that short term myristoyl-LPC administration can significantly alter renal function producing a weak natriuresis and diuresis which is not dependent on systemic blood pressure and renal hemodynamic changes.
Handa
R K
RK
Department of Medicine/Nephrology, Wake Forest University Medical Center, Winston-Salem, North Carolina 27157-1053.
Buckalew
V M
VM
D000704:Analysis of Variance; D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D008244:Lysophosphatidylcholines / Q000494:pharmacology*; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D010424:Pentobarbital; D051381:Rats; D017207:Rats, Sprague-Dawley; D012044:Regression Analysis; D012079:Renal Circulation / Q000187:drug effects*
D008244:Lysophosphatidylcholines; D010424:Pentobarbital