Renal effects of growth hormone. II. Electrolyte homeostasis and body composition.
Growth hormone (GH), either directly or through insulin-like growth factor-1 (IGF-1), has a wide spectrum of physiological and renal effects. This review concentrates on the effects of GH (derived from either pituitary or recombinant technology) and IGF-1 in three main areas: (1) sodium and water homeostasis; (2) calcium and phosphate balance, bone density and interactions with mineral regulating hormones; (3) fat and lean body mass. Observations of physiological changes in states of GH deficiency and excess in humans and animal models are presented. The lack of long-term toxicological data indicates that GH treatment for short stature in non-GH deficient children, with or without renal disease, should proceed with caution.
Ogle
G D
GD
Department of Nephrology, Prince of Wales Children's Hospital, Randwick, Sydney, Australia.
Rosenberg
A R
AR
Kainer
G
G
D000818:Animals; D001823:Body Composition / Q000187:drug effects*; D013006:Growth Hormone / Q000494:pharmacology*; D006706:Homeostasis / Q000187:drug effects*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D013006:Growth Hormone