[Transfusion-associated graft-vs-host disease in a patient with Hodgkin's disease].
Transfusion-associated graft-versus-host disease (TA-GVHD) is a serious complication of blood transfusion which is caused by immunocompetent donor lymphocytes reacting against recipient antigens. We report a case of TA-GVHD in a male patient with Hodgkin's disease who had received several units of non-irradiated blood components. TA-GVHD was diagnosed by histological examination of affected skin and demonstration of engrafted lymphocytes of female phenotype by in situ hybridization using a Y-chromosome specific probe. The need to irradiate blood components given to patients in defined risk-groups is stressed.
Lillevang
S T
ST
Klinisk immunologisk afdeling, Odense Sygehus.
Andersen
C B
CB
Schmidt
K G
KG
Riisom
K
K
D000328:Adult; D017707:Erythrocyte Transfusion; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D006689:Hodgkin Disease / Q000276:immunology / Q000628:therapy*; D006801:Humans; D008297:Male; D017713:Platelet Transfusion; D065227:Transfusion Reaction
Transfusionsassocieret graft-versus-host disease hos en patient med Hodgkin's sygdom.