title: Flow cytometric analysis of small renal tumors.
abstract: Flow cytometric deoxyribonucleic acid (DNA) content analysis was performed on 26 renal tumors 3.0 cm. or less in maximum diameter. We noted DNA aneuploid cell populations in 8 of 25 tumors (32%) evaluable for DNA ploidy status. DNA aneuploid cells comprised 7 to 59% of the cells in those tumors. In comparison, 12 of 25 tumors (48%) larger than 3.0 cm. had aneuploid cell populations. S phase cell populations were significantly increased in the small aneuploid tumors compared with the small diploid tumors (p < 0.001). We believe that these small tumors have the potential to behave aggressively and, therefore, they should be treated no differently than larger renal neoplasms.
authors.affiliation: Department of Urology, Northwestern University Medical School, Chicago, Illinois.
authors.forename: W J
authors.initials: WJ
authors.lastname: Ellis
authors.forename: K D
authors.initials: KD
authors.lastname: Bauer
authors.forename: R
authors.initials: R
authors.lastname: Oyasu
authors.forename: K T
authors.initials: KT
authors.lastname: McVary
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011003:Ploidies; D016196:S Phase
chemical_list: D004273:DNA, Neoplasm