[Dissolution rate and bioavailability of famotidine tablets].
An automated dissolution test system was used for the determination of the dissolution rate of famotidine tablets, and a mean cumulative dissolution rate of 97.40 +/- 0.31% in 15 min was obtained. To each of six healthy volunteers, 40 mg of famotidine tablets were administered orally, then an automated HPLC with switching column system was used to analyze famotidine in plasma. Variation of drug concentration vs time were fitted to curves. By comparison of calculated values with observed ones, the results could be described as one-compartment model in human. According to a statistic moment algorithm, the results of calculation showed that T1/2 = 2.92 h and Frel = 118.8%.
Lu
B
B
School of Pharmacy, West China University of Medical Sciences, Chengdu.
He
Y J
YJ
Guo
P
P
Ye
L M
LM
D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D015738:Famotidine / Q000493:pharmacokinetics*; D006801:Humans; D012995:Solubility; D013607:Tablets
D013607:Tablets; D015738:Famotidine