Prospective study of short and ultrashort regimens of gonadotropin-releasing hormone agonist in an in vitro fertilization program.
OBJECTIVE
To assess the usefulness of the ultrashort regimen of gonadotropin-releasing hormone agonist (GnRH-a) in ovulation induction in an in vitro fertilization (IVF) program.


METHODS
A prospective randomized trial comparing short and ultrashort regimens of GnRH-a.


METHODS
Aberdeen Assisted Reproduction Unit.


METHODS
Forty-eight patients having IVF for the first time were randomized between the two protocols.


METHODS
Response to ovarian stimulation and occurrence of spontaneous luteinizing hormone (LH) surges.


RESULTS
In ovulation induction, fertilization, and pregnancy rates the ultrashort regimen produces results that were no different to the short regimen but it did not always prevent an LH surge.


CONCLUSIONS
The ultrashort regimen can be a useful alternative for ovarian stimulation of patients undergoing IVF.
Acharya
U
U
Department of Obstetrics and Gynaecology, University of Aberdeen, Aberdeen Maternity Hospital, Scotland.
Irvine
S
S
Hamilton
M
M
Templeton
A
A
D000328:Adult; D002064:Buserelin / Q000008:administration & dosage* / Q000627:therapeutic use; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D004624:Embryo Transfer; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism; D009640:Norethindrone / Q000627:therapeutic use; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D011446:Prospective Studies
D006063:Chorionic Gonadotropin; D004958:Estradiol; D007986:Luteinizing Hormone; D002064:Buserelin; D009640:Norethindrone