title: Antibiotic-associated fulminant pseudomembranous colitis without toxic megacolon.
abstract: Presented is a middle-aged male who developed a fulminant case of antibiotic-associated pseudomembranous colitis characterized by leukocytosis, hypoalbuminemia, ascites, and anasarca without toxic megacolon. The patient responded slowly to medical therapy consisting of intravenous metronidazole, oral vancomycin, and parenteral nutrition. Subsequently, cholestyramine was administered. A review of the literature concerning similar cases of fulminant pseudomembranous colitis is presented.
authors.affiliation: Department of Internal Medicine, National Naval Medical Center, Bethesda, Maryland.
authors.forename: B E
authors.initials: BE
authors.lastname: Herman
authors.forename: J
authors.initials: J
authors.lastname: Vargo
authors.forename: W S
authors.initials: WS
authors.lastname: Phillips
authors.forename: W B
authors.initials: WB
authors.lastname: Sweeney
authors.forename: R J
authors.initials: RJ
authors.lastname: Volpe
mesh_terms: D002981:Clindamycin / Q000009:adverse effects*; D004761:Enterocolitis, Pseudomembranous / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008532:Megacolon, Toxic / Q000175:diagnosis; D008875:Middle Aged; D012812:Sigmoidoscopy; D014057:Tomography, X-Ray Computed
chemical_list: D002981:Clindamycin