title: Late death after arterial switch operation for transposition of the great arteries.
abstract: Fifty-nine patients survived for more than 1 month after an arterial switch operation (ASO). Diagnoses in these patients included transposition of the great arteries in 27, transposition of the great arteries with ventricular septal defect in 28, and double-outlet right ventricle in four. There were six late deaths (10%) during the follow-up period, and all of them occurred suddenly and unexpectedly. Four of the six late deaths were in patients who had undergone ASO in the neonatal period. Late deaths occurred from 40 days to 10 months after the operation. Autopsies were performed in all six patients. The cause of these late deaths was acute myocardial infarction. Five patients died of subendocardial infarction resulting from stenosis of the left main coronary artery. On pathologic examination, a fibrocellular intimal thickening was noted at the proximal region of the right and left coronary arteries, which resulted in 80% stenosis on average.
authors.affiliation: Department of Pediatrics, Kure National Hospital, Hiroshima, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Tsuda
authors.forename: M
authors.initials: M
authors.lastname: Imakita
authors.forename: T
authors.initials: T
authors.lastname: Yagihara
authors.forename: Y
authors.initials: Y
authors.lastname: Ono
authors.forename: S
authors.initials: S
authors.lastname: Echigo
authors.forename: O
authors.initials: O
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Kamiya
mesh_terms: D000015:Abnormalities, Multiple / Q000601:surgery*; D006348:Cardiac Surgical Procedures / Q000379:methods; D003251:Constriction, Pathologic; D017023:Coronary Angiography; D003327:Coronary Disease / Q000209:etiology / Q000401:mortality / Q000473:pathology; D004310:Double Outlet Right Ventricle / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006345:Heart Septal Defects, Ventricular / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009203:Myocardial Infarction / Q000209:etiology / Q000401:mortality* / Q000473:pathology; D011183:Postoperative Complications / Q000401:mortality* / Q000473:pathology; D013997:Time Factors; D014188:Transposition of Great Vessels / Q000601:surgery*