title: Additional antitumor ecteinascidins from a Caribbean tunicate: crystal structures and activities in vivo.
abstract: Ecteinascidins (Ets), isolated from the Caribbean tunicate Ecteinascidia turbinata, protect mice in vivo against P388 lymphoma, B16 melanoma, M5076 ovarian sarcoma, Lewis lung carcinoma, and the LX-1 human lung and MX-1 human mammary carcinoma xenografts. Crystal structures of two tris(tetrahydroisoquinoline) Ets were investigated with single crystals of the 21-O-methyl-N12-formyl derivative of Et 729 and the natural N12-oxide of Et 743. Representatives of an additional class of Ets, Et 722 and Et 736, isolated from the same organism, were assigned tetrahydro-beta-carboline-substituted bis(tetrahydroisoquinoline) structures by NMR and fast atom bombardment MS spectra.
authors.affiliation: School of Chemical Sciences, University of Illinois, Urbana 61801.
authors.forename: R
authors.initials: R
authors.lastname: Sakai
authors.forename: K L
authors.initials: KL
authors.lastname: Rinehart
authors.forename: Y
authors.initials: Y
authors.lastname: Guan
authors.forename: A H
authors.initials: AH
authors.lastname: Wang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D002470:Cell Survival / Q000187:drug effects; D003198:Computer Simulation; D003461:Crystallography; D004247:DNA / Q000737:chemistry; D007546:Isoquinolines / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009374:Neoplasms, Experimental / Q000188:drug therapy; D014561:Urochordata / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D000970:Antineoplastic Agents; D007546:Isoquinolines; D004247:DNA