[Ligand spectrum of hemoglobin activity of methemoglobin-reductase and hemolytic resistance of erythrocytes during chronic exposure to nitrates].
It is found that nitrite-ions formed as a result of biotransformation during long term feeding of calves with sodium and potassium nitrates induce changes in some biochemical parameters of blood, including HS-glutathione content in erythrocytes, acid hemolytic resistance of erythrocytes, activity of NAD-dependent methemoglobin-reductase, correlation of ligand forms of hemoglobin and its total content. It is supposed that the observed changes are of an adaptational character and, as a whole, provide for the optimization of both quantitative and qualitative composition of population of erythroid cells at the expense of erythropoiesis intensification.
Kiiza
D A
DA
Artiukh
V P
VP
Starodub
N F
NF
Khmel'nitskiĭ
G A
GA
D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D002417:Cattle; D042966:Cytochrome-B(5) Reductase / Q000097:blood*; D004912:Erythrocytes / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D005978:Glutathione / Q000097:blood; D006454:Hemoglobins / Q000378:metabolism*; D006461:Hemolysis / Q000187:drug effects; D008024:Ligands; D009566:Nitrates / Q000493:pharmacokinetics / Q000494:pharmacology*; D009573:Nitrites / Q000378:metabolism; D013997:Time Factors
D006454:Hemoglobins; D008024:Ligands; D009566:Nitrates; D009573:Nitrites; D042966:Cytochrome-B(5) Reductase; D005978:Glutathione
Ligandnyĭ spektr gemoglobina, aktivnost' metgemoglobin-reduktazy i gemoliticheskaia ustoĭchivost' éritrotsitov pri khronicheskom vozdeĭstvii nitratov.