Medial frontal cortex lesions impair the aiming component of rat reaching.
This study examined the contribution of medial frontal cortex (the medial portion of supplementary motor cortex, or Fr1) to the performance of rats on trained, or 'skilled', reaching tasks. Unilateral medial frontal cortex lesions moderately impaired reaching success on a task that demanded accuracy but they did not impair performance on a less demanding reaching task nor did they affect limb preference. Kinematic analyses indicated that the aiming component, in which the forearm of the limb is aligned along the midline of the body by adduction of the elbow, was chronically impaired. Rather than adducting the elbow to aim, the rats used a number of limb and whole body postural adjustments to compensate for incomplete or absent aiming. That medial frontal cortex is involved in the execution of at least one component of skilled reaching implies that a larger area of frontal cortex is involved in skilled limb movement than has been suggested by previous studies. The results also suggest that the different regions of frontal cortex may each have a relatively selective involvement in the execution of only a subset of the movements comprising a reach.
Whishaw
I Q
IQ
Department of Psychology, University of Lethbridge, Alta., Canada.
Pellis
S M
SM
Gorny
B P
BP
D000818:Animals; D001288:Attention / Q000502:physiology*; D001931:Brain Mapping; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D005552:Forelimb / Q000294:innervation*; D007699:Kinesthesis / Q000502:physiology; D011939:Mental Recall / Q000502:physiology; D009044:Motor Cortex / Q000502:physiology*; D009949:Orientation / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology*; D051381:Rats