[Heparan sulfate: its kinetic effects on fibrinolytic-coagulative parameters after oral administration].
The effects of the oral administration of 100 or 200 mg of heparan sulphate or placebo over time were assessed in nine healthy volunteers. Blood samples were collected at 1, 2, 4, 6, 8 and 12 hours after administration to assay prothrombin activity, partially activated thromboplastin time, and the activation to tPA and PAI-1. A significant increase (P < 0.001) of tPA activity and a reduced inhibition of fibrinolytic systems by PAI-1 were observed. These effects, which were clearly dose-dependent, appeared 2 hours after administration and persisted for 6-8 hours. On the contrary, no changes were recorded in coagulative tests at the doses used.
Agrati
A M
AM
II Divisione Medicina Generale Brera, Ospedale Niguarda Ca' Granda, Milano.
De Bartolo
G
G
Palmieri
G
G
D000284:Administration, Oral; D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005342:Fibrinolysis / Q000187:drug effects*; D006497:Heparan Sulfate / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D006801:Humans; D008297:Male; D012016:Reference Values; D012107:Research Design; D013997:Time Factors
D006497:Heparan Sulfate
Eparansolfato: cinetica degli effetti su parametri fibrinolitico-coagulativi dopo somministrazione orale.