title: Appearance of adherent cells suppressive to erythropoiesis during an early stage of Plasmodium berghei infection in mice.
abstract: We examined the effect of adherent cells from bone marrow or spleen of mice infected with Plasmodium berghei on dyserythropoiesis. Significant reduction in number of erythroid progenitors (erythroid colony-forming units: CFU-E and erythroid burst-forming units: BFU-E) was observed in bone marrow as early as 1 day after P. berghei infection. When adherent cells were removed from bone marrow or spleen cells of infected mice, the number of CFU-E and BFU-E was clearly increased. Furthermore, addition of adherent cells from infected mice to nonadherent cells from normal mice inhibited erythroid colony formation significantly in a dose-dependent manner. These results suggest that the adherent cells obtained from bone marrow or spleen of mice in the early stage of P. berghei-infection have a suppressive effect on erythropoiesis.
authors.affiliation: Department of Parasitology, Miyazaki Medical College, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Asami
authors.forename: T
authors.initials: T
authors.lastname: Abe
authors.forename: M
authors.initials: M
authors.lastname: Owhashi
authors.forename: Y
authors.initials: Y
authors.lastname: Nawa
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells; D015672:Erythroid Precursor Cells / Q000276:immunology*; D004920:Erythropoiesis / Q000276:immunology*; D005260:Female; D006801:Humans; D007223:Infant; D008288:Malaria / Q000276:immunology*; D051379:Mice; D010965:Plasmodium malariae / Q000166:cytology / Q000276:immunology*; D013154:Spleen / Q000166:cytology; D013491:Suppressor Factors, Immunologic / Q000502:physiology
chemical_list: D013491:Suppressor Factors, Immunologic