[Effects of luteinizing hormone-releasing hormone agonist on bladder carcinogenesis in male rats].
In previous studies, it has been suggested that the suppression of testicular androgen had inhibits bladder carcinogenesis. In this study we investigated which phase of bladder carcinogenesis is inhibited by the hormonal change of the hypothalamus-pituitary-testicular axis induced by the depot form of the LH-RH agonist. All rats were treated with 0.05% BBN in tap water for 8 weeks and were observed for the following 16 weeks. They were divided into five groups. Group 1 (Control group); The LH-RH agonist was not administered. Group 2 (Initiation group); The LH-RH agonist (depot form) was administered subcutaneously two weeks before and after the initiation of the experiment. Group 3 (Promotion group); The LH-RH agonist (depot form) was subcutaneously administered at intervals of 4 weeks starting 6 weeks after the initiation of the experiment. Group 4 (Full term group); The LH-RH agonist (depot form) was administered subcutaneously at intervals of 4 weeks starting from 2 weeks before the initiation of the experiment. Group 5 (Castration group); Bilateral orchiectomy was performed one week before the beginning of the experiment. From our results, the followings were suggested, (1) more intensive inhibition of bladder carcinogenesis was observed in the group which received the LH-RH agonist (depot form), compared with the Castration group, (2) the bladder carcinogenesis was more intensively inhibited when the LH-RH analogue (depot from) was given in the promotion phase and (3) not only testosterone but also the regulatory system of the hypothalamus-pituitary-testicular axis is related to the bladder carcinogenesis.(ABSTRACT TRUNCATED AT 250 WORDS)
Matsuki
K
K
Department of Urology, Faculty of Medicine, University of Tokyo.
Akaza
H
H
Aso
Y
Y
D000818:Animals; D002085:Butylhydroxybutylnitrosamine; D007031:Hypothalamus / Q000502:physiology; D007279:Injections, Subcutaneous; D016729:Leuprolide / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009919:Orchiectomy; D010902:Pituitary Gland / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013737:Testis / Q000502:physiology; D013739:Testosterone / Q000037:antagonists & inhibitors; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000517:prevention & control
D002085:Butylhydroxybutylnitrosamine; D013739:Testosterone; D016729:Leuprolide