[Pharmacokinetics of gentamicin after intratracheal administration in tracheotomy patients].
Seventeen tracheotomy patients were given gentamicin (Gen) into trachea at the dosage of 2 and 4 mg.kg-1. Gen concentration in serum was determined by fluorescence polarization immunoassay. Pharmacokinetic parameters were calculated by micro-computer pharmacokinetic program (MCPKP). T1/2Ka, Tp, and Cmax were 0.6 +/- 0.3 h, 1.7 +/- 0.7 h, and 4.6 +/- 1.8 micrograms.ml-1, respectively in 4 mg.kg-1 group and 0.3 +/- 0.3 h, 0.9 +/- 0.5 h, and 0.4 +/- 0.2 microgram.ml-1, respectively in 2 mg.kg-1 group (P < 0.05). T1/2Kel was 30 +/- 11 h in patients of serum creatine (Cr) > 2 mg% and 6 +/- 5 h in patients of Cr < 2 mg% (P < 0.01). No significant difference could be found between Cmax of different renal function patients (P > 0.05).
Gu
C N
CN
Department of Clinical Pharmacology, Changzheng Hospital, Shanghai, China.
Shan
H W
HW
Deng
Y L
YL
Zhu
C J
CJ
Ding
X H
XH
Gu
Q P
QP
D000328:Adult; D005839:Gentamicins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D008875:Middle Aged; D011184:Postoperative Period; D012141:Respiratory Tract Infections / Q000378:metabolism / Q000601:surgery; D014132:Trachea; D014140:Tracheotomy
D005839:Gentamicins