[Noradrenaline fluorescence histochemical study on the locus coeruleus of kindling rat induced by coriaria lactone].
Fourteen male Wistar rats were divided into two groups. The experimental rats were injected with subconvulsive dosage of coriaria lactone (1 mg/kg) intramuscularly per 3.5 days. The controls were injected with normal saline. After 26 injections, the loci coeruleus of kindling rats were studied with the noradrenaline (NA) fluorescence histochemical technique at the time between seizures. The NA fluorescence could be clearly visualized under fluorescent microscope. The intensity of fluorescence was reflected by autoexposure-meter of the fluorescent microscope. The brighter the fluorescence, the shorter the autoexposure time. The intensity of NA fluorescence in the locus coeruleus of experimental animals was weaker than that of the controls. Since NA plays an inhibitory role in cerebral cortex, the decrease of NA, either induced by repeated injections of coriaria lactone or due to the time of sample taken after seizure, needs further study.
Wu
L
L
Fang
Y
Y
Song
Y
Y
D000818:Animals; D004827:Epilepsy / Q000139:chemically induced / Q000378:metabolism*; D006651:Histocytochemistry; D007696:Kindling, Neurologic / Q000378:metabolism*; D007783:Lactones; D008125:Locus Coeruleus / Q000378:metabolism*; D008297:Male; D008856:Microscopy, Fluorescence; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D007783:Lactones; C049836:coriaria lactone; D009638:Norepinephrine