title: [An increase in the immunogenicity of bacterial antigens under the influence of one of the derivatives of muramyl dipeptide].
abstract: As revealed in animal experiments, glucosaminylmuramyl dipeptide (GMDP), the synthetic analog of muramyl dipeptide, when introduced intraperitoneally in a single injection or orally, exhibits adjuvant activity with respect to Citrobacter 0-antigens, Shigella flexneri and enhances the protective properties of dysentery and pertussis vaccines. The stimulating properties of GMDP depend on its dose, the route of its administration, the time elapsed after its administration, its ratio to the concomitant doses of bacterial antigens and to the dose of the virulent culture used for challenge.
authors.forename: M V
authors.initials: MV
authors.lastname: Britsina
authors.forename: I B
authors.initials: IB
authors.lastname: Shepeleva
authors.forename: A P
authors.initials: AP
authors.lastname: Baturo
authors.forename: S I
authors.initials: SI
authors.lastname: Elkina
authors.forename: N G
authors.initials: NG
authors.lastname: Kalina
authors.forename: T M
authors.initials: TM
authors.lastname: Andronova
authors.forename: E V
authors.initials: EV
authors.lastname: Ermolova
authors.forename: N S
authors.initials: NS
authors.lastname: Zakharova
authors.forename: V T
authors.initials: VT
authors.lastname: Ivanov
authors.forename: T V
authors.initials: TV
authors.lastname: Sokolova
mesh_terms: D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000008:administration & dosage / Q000187:drug effects* / Q000276:immunology; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology; D001886:Bordetella pertussis / Q000276:immunology; D002954:Citrobacter / Q000276:immunology; D007114:Immunization; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000276:immunology; D011817:Rabbits; D012763:Shigella flexneri / Q000276:immunology; D012995:Solubility
chemical_list: D000276:Adjuvants, Immunologic; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D010567:Pertussis Vaccine; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C023868:N-acetyl-beta-glucosaminyl-N-acetylmuramyl-alanylisoglutamine
vernacular_title: Povyshenie immunogennosti bakterial'nykh antigenov pod vliianiem odnogo iz derivatov muramildipeptida.