title: Efficacy of Arthrotec in the treatment of rheumatoid arthritis.
abstract: In a double-blind study, 346 patients with active rheumatoid arthritis were randomly assigned to receive Arthrotec, a combination of 50 mg of diclofenac and 200 *g of misoprostol, or 50 mg of diclofenac; the drugs were given two or three times daily for 12 weeks. At weeks 4, 8, and 12 of treatment, no clinically significant differences between the two treatment groups were noted on measures of joint tenderness, pain, and swelling or on physicians' and patients' assessments of disease severity.
authors.affiliation: Civils Hospices, Strasbourg, France.
authors.forename: J R
authors.initials: JR
authors.lastname: Hannequin
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D004008:Diclofenac / Q000008:administration & dosage / Q000592:standards* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016595:Misoprostol / Q000008:administration & dosage / Q000592:standards* / Q000600:supply & distribution / Q000627:therapeutic use
chemical_list: C078133:Arthrotec; D004338:Drug Combinations; D016595:Misoprostol; D004008:Diclofenac