Modifications of ependymal cells membranes by galactocerebrosides in cell culture.
In this paper we have demonstrated that treatment of ependymal cells in culture by galactocerebrosides induced a decrease in plasma membrane fluidity and an increase of EGF binding sites. We have shown in a previous work that galactocerebroside in vitro and in vivo caused an important morphological change in ependymal cells that grew into an astrocytic shape after a five day treatment. We discuss the hypothesis that the first event in morphological effect could be a modification of plasma membrane followed by important changes in molecules distribution.
Laabich
A
A
LNMIC, Centre de Neurochimie du CNRS, Strasbourg, France.
Delaunoy
J P
JP
Cremel
G
G
Staedel
C
C
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects; D002478:Cells, Cultured; D004805:Ependyma / Q000166:cytology* / Q000187:drug effects; D066246:ErbB Receptors / Q000187:drug effects; D005453:Fluorescence; D005699:Galactosylceramides / Q000494:pharmacology*; D008560:Membrane Fluidity / Q000187:drug effects; D008854:Microscopy, Electron; D051381:Rats
D005699:Galactosylceramides; D066246:ErbB Receptors