Muscarinic and nicotinic activities of the novel acetylcholine analog acetylselenonium choline.
The present paper further characterizes the cholinergic properties of acetylselenonium choline (ASeCh, (CH3)2Se+CH2CH2OCOCH3). The data demonstrate that ASeCh possesses muscarinic receptor agonist properties as evidenced by vasodepressor and smooth muscle contractile activities which are enhanced by physostigmine and antagonized by atropine. ASeCh also possessed nicotinic agonist activity on frog rectus abdominis tissue which was potentiated by physostigmine, and blocked by d-tubocurarine. The relative potencies of ASeCh ranged from approximately 1% to approximately 6% of the potency of acetylcholine in the three types of preparations examined.
Khatri
J N
JN
College of Pharmacy, University of South Carolina, Columbia 29208.
Silks
L A
LA
Dunlap
R B
RB
Odom
J D
JD
Kosh
J W
JW
D000109:Acetylcholine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009132:Muscles / Q000187:drug effects; D016566:Organoselenium Compounds / Q000494:pharmacology*; D010830:Physostigmine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011976:Receptors, Muscarinic / Q000187:drug effects*; D011978:Receptors, Nicotinic / Q000187:drug effects*; D014403:Tubocurarine / Q000494:pharmacology
D016566:Organoselenium Compounds; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; C077292:acetylselenonium choline; D001285:Atropine; D010830:Physostigmine; D000109:Acetylcholine; D014403:Tubocurarine