title: [Bioavailability of a controlled-release suspension of phenylpropanolamine in healthy volunteers].
abstract: A high-performance liquid chromatographic analysis of phenylpropanolamine (PPA) in human plasma is presented. Using direct UV detection the method is sufficiently sensitive to 25 ng/ml for PPA. Single-dose pharmacokinetics of PPA in 10 healthy volunteers taking controlled release suspension (C) or tablet (T), each containing 150 mg PPA was compared. The study described here has shown that the (C) AUC(0-infinity)/(T) AUC(0-infinity) = 1.02 (P greater than 0.4). The controlled-release product of PPA is equivalent to PPA tablet.
authors.affiliation: Zhongshan Hospital, Shanghai Medical University.
authors.forename: Q C
authors.initials: QC
authors.lastname: Chen
authors.forename: W L
authors.initials: WL
authors.lastname: Chen
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Dai
authors.forename: G Q
authors.initials: GQ
authors.lastname: Ge
authors.forename: D C
authors.initials: DC
authors.lastname: Lin
mesh_terms: D000328:Adult; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008297:Male; D010665:Phenylpropanolamine / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D010665:Phenylpropanolamine