[Lymphocyte subpopulation state of the human lung during prenatal development].
Distribution of surface lymphocyte markers was assessed in foetus lung by cytofluorimetry using monoclonal antibodies produced by "Ortho Diagnostic systems" and "Becton Dickinson". Seven lymphocyte subpopulations were detected in developing lungs even at the pseudoglandular stage (8-15 weeks). There was a significant increase in these lymphocyte subpopulations in canalicular stage. Quantity of T3+ cells increased 8-fold and B-cells 10-fold. There was a tendency to increased number of cortical thymocytes (T6+), and to decreased ratio T6+/T3+ lymphocytes. The ratio of immunoregulatory lymphocyte subpopulations (T4+/T8+) resembled that of these subpopulations in adult human lung rather than in cord blood. In canalicular stage the share of lung lymphoid cells in S-phase was decreased.
Van'ko
L V
LV
Timoshchuk
O A
OA
Nikolaeva
M A
MA
Romanova
L K
LK
Sukhikh
G T
GT
D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes; D005434:Flow Cytometry; D005865:Gestational Age; D006801:Humans; D008168:Lung / Q000166:cytology* / Q000196:embryology*; D016131:Lymphocyte Subsets; D013601:T-Lymphocytes
D000911:Antibodies, Monoclonal
Subpopuliatsionnyĭ sostav limfotsitov legkogo cheloveka v antenatal'nom periode razvitiia.