Recurrent aphthous stomatitis: the efficacy of replacement therapy in patients with underlying hematinic deficiencies.
A group of thirty-four patients with recurrent aphthous stomatitis (RAS) and single hematinic deficiencies were given replacement therapy after any reason for the deficiency had been sought and excluded. The response of the RAS was assessed in an open trial. The aphthae in 70% of patients subjectively improved with hematinic replacement therapy, a benefit exceeding the defined placebo response in recurrent aphthous stomatitis.
Porter
S
S
Centre for the Study of Oral Disease, Bristol Dental Hospital and School.
Flint
S
S
Scully
C
C
Keith
O
O
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D005492:Folic Acid / Q000097:blood / Q000627:therapeutic use*; D005494:Folic Acid Deficiency / Q000097:blood / Q000188:drug therapy; D005500:Follow-Up Studies; D006801:Humans; D007501:Iron / Q000097:blood / Q000627:therapeutic use*; D000090463:Iron Deficiencies; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D013281:Stomatitis, Aphthous / Q000097:blood / Q000188:drug therapy*; D014805:Vitamin B 12 / Q000097:blood / Q000627:therapeutic use*; D014806:Vitamin B 12 Deficiency / Q000097:blood / Q000188:drug therapy
D005492:Folic Acid; D007501:Iron; D014805:Vitamin B 12