title: Metabolic disturbances in hypertension: results from the population study 'men born in 1913'.
abstract: A clustering of metabolic disturbances has been indicated in hypertension. The distribution of such factors was assessed among hypertensives and normotensives in a general population sample of 644 men aged 67 years. Fasting serum insulin, glucose and triglyceride levels were measured. In this study hypertension was defined as DBP > or = 95 mmHg or present use of antihypertensives. Impaired glucose tolerance (IGT) or diabetes mellitus, hyperinsulinaemia (> or = 20 mU l-1) and hypertriglyceridaemia (> or = 2.3 mmol l-1) were defined as metabolic disturbances. When all these disturbances were present simultaneously a complete 'metabolic syndrome' was considered to be present. Hypertension was found in 185 (29%) men, IGT in 15%, diabetes mellitus in 11%, hyperinsulinaemia in 18% and hypertriglyceridaemia in 19%. Among hypertensives, 11 (6%) men had a 'metabolic syndrome', compared to 12 (3%) men in the normotensive group (P = 0.039). At least one metabolic disturbance was present in 109 (59%) of the hypertensive men, and in 173 (38%) of the normotensive men (P < 0.001). The prevalence rates of metabolic disturbances did not differ significantly between lean (BMI < 26 kg m-2) and obese (BMI > or = 26 kg m-2) hypertensives. Only hypertriglyceridaemia was more frequent in obese than in lean hypertensives (20% vs. 37%, P = 0.015). The 'metabolic syndrome' was found in 6% of all hypertensives, which was twice as common as in the normotensive population. The 'metabolic syndrome' was uncommon in both lean and obese hypertensives (5% vs. 7%, NS). These findings indicate that hypertension and metabolic disturbances may have a common underlying cause, at least in some individuals.
authors.affiliation: Department of Medicine, University of Göteborg, Ostra Hospital, Göteborg, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Eriksson
authors.forename: L
authors.initials: L
authors.lastname: Welin
authors.forename: L
authors.initials: L
authors.lastname: Wilhelmsen
authors.forename: B
authors.initials: B
authors.lastname: Larsson
authors.forename: L O
authors.initials: LO
authors.lastname: Ohlson
authors.forename: K
authors.initials: K
authors.lastname: Svärdsudd
authors.forename: G
authors.initials: G
authors.lastname: Tibblin
mesh_terms: D000368:Aged; D000886:Anthropometry; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D015992:Body Mass Index; D016000:Cluster Analysis; D003920:Diabetes Mellitus / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D005215:Fasting; D005951:Glucose Tolerance Test; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D006973:Hypertension / Q000150:complications* / Q000453:epidemiology / Q000378:metabolism; D015228:Hypertriglyceridemia / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D007328:Insulin / Q000097:blood; D008297:Male; D009765:Obesity / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology; D011159:Population Surveillance; D011446:Prospective Studies; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology
chemical_list: D001786:Blood Glucose; D007328:Insulin