title: Serum creatine-kinase-BB concentration in very low birth weight babies with posthemorrhagic ventricular dilatation.
abstract: The association between measurements of lateral ventricle dilatation determined by serial ultrasound and brain specific creatine-kinase isoenzyme patterns (CK-BB) is studied in 60 very low birth weight preterm neonates of 1,500 g birth weight or 32 weeks gestation or less. The patients were divided into three groups according to cranial ultrasonographic findings: Group A (n = 20) had isolated peri-intraventricular hemorrhage (PIVH); group B (n = 20) had PIVH and dilated ventricles (VM); group C (n = 20) were normal matched preterms and formed the control group. Compared to control babies or those with isolated PIVH, high serum concentrations of CK-BB were observed after birth in babies with persistent dilated ventricles at two weeks postnatal age (p less than 0.01). No difference was found between CK-BB levels of babies with isolated PIVH and control group (p greater than 0.05). We suggest that an elevated CK-BB value is found in babies with persistent ventricular dilatation suggesting severe and diffuse brain damage after post-hemorrhagic ventriculomegaly (VM).
authors.affiliation: Department of Pediatrics, Children's Hospital, Aarau, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Amato
authors.forename: P
authors.initials: P
authors.lastname: Hüppi
authors.forename: R
authors.initials: R
authors.lastname: Gambon
mesh_terms: D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging / Q000201:enzymology* / Q000473:pathology; D002552:Cerebral Ventricles / Q000000981:diagnostic imaging / Q000473:pathology*; D003402:Creatine Kinase / Q000097:blood*; D004453:Echoencephalography; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007527:Isoenzymes; D008297:Male
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase