[The interaction between neural activity and intracellular pH].
The regulation of intracellular pH (pH(i)) in the nervous system has been vigorously studied using a variety of animal cells in the last decade, through advances in techniques for measuring pH(i) accurately in living cells. These studies have elucidated the mechanisms of pH(i) regulation, such as intracellular buffering and acid transport across the cell membrane, in neurons and glial cells. Following an outline of pH(i) regulation, the interaction between neural activity and acid-base balance is discussed. The dynamic change of pH(i), produced by neural activity, and the effect of pH(i) on the electrical properties of neurons and other excitable cells is emphasized.
Komatsu
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Department of Physiology, Tokyo Women's Medical College.
D000136:Acid-Base Equilibrium; D000818:Animals; D009424:Nervous System Physiological Phenomena; D009474:Neurons / Q000502:physiology