title: Botulinum toxin in the treatment of chronic urinary retention in women.
abstract: Six women were identified as having difficulty in voiding or complete urinary retention due to abnormal myotonic-like electromyographic (EMG) activity in the striated muscle of the urethral sphincter. An attempt was made to improve voiding by injection of botulinum toxin into the striated sphincter muscle. Although 3 patients then developed transient stress incontinence, demonstrating that sufficient botulinum toxin had been given to cause sphincter weakness, no patient had significant symptomatic benefit.
authors.affiliation: Department of Uro-Neurology, National Hospital for Neurology and Neurosurgery, London.
authors.forename: C J
authors.initials: CJ
authors.lastname: Fowler
authors.forename: C D
authors.initials: CD
authors.lastname: Betts
authors.forename: T J
authors.initials: TJ
authors.lastname: Christmas
authors.forename: M
authors.initials: M
authors.lastname: Swash
authors.forename: C G
authors.initials: CG
authors.lastname: Fowler
mesh_terms: D000328:Adult; D001905:Botulinum Toxins / Q000627:therapeutic use*; D004576:Electromyography; D005260:Female; D006801:Humans; D008875:Middle Aged; D009132:Muscles / Q000503:physiopathology; D012648:Self Care; D014521:Urethra / Q000503:physiopathology; D014546:Urinary Catheterization; D016055:Urinary Retention / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology
chemical_list: D001905:Botulinum Toxins