The protective activity of tea catechins against experimental infection by Vibrio cholerae O1.
Tea catechins inhibited the fluid accumulation induced by cholera toxin in sealed adult mice. The catechins also reduced fluid accumulation by Vibrio cholerae O1 in ligated intestinal loops of rabbits. These findings suggest that tea catechins may possess protective activity against V. cholerae O1.
Toda
M
M
Department of Microbiology and Immunology, Showa University School of Medicine, Tokyo, Japan.
Okubo
S
S
Ikigai
H
H
Suzuki
T
T
Suzuki
Y
Y
Hara
Y
Y
Shimamura
T
T
D000818:Animals; D001826:Body Fluids / Q000187:drug effects / Q000502:physiology; D002392:Catechin / Q000302:isolation & purification / Q000494:pharmacology*; D002771:Cholera / Q000503:physiopathology / Q000517:prevention & control*; D002772:Cholera Toxin / Q000037:antagonists & inhibitors / Q000633:toxicity; D004195:Disease Models, Animal; D007422:Intestines / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011817:Rabbits; D013662:Tea / Q000737:chemistry*
D013662:Tea; D002392:Catechin; D002772:Cholera Toxin