Effects of dipentylnitrosamine (DPNA) on the respiratory tract of rats.
Wistar rats (40 males and 40 females), treated over a period of 25 weeks with subcutaneous injections of dipentylnitrosamine (DPNA) at doses of 0, 62.5, 125 and 250 mg/kg body weight showed dose-dependent, sex-related, proliferative and metaplastic alterations in the upper and lower respiratory tract within one year. The biologic behavior of the induced lung tumors is very similar to that of human lung adenocarcinomas.
Kamino
K
K
Institute of Experimental Pathology, Hannover Medical School, Germany.
Mohr
U
U
D000230:Adenocarcinoma / Q000139:chemically induced / Q000473:pathology*; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000473:pathology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced / Q000473:pathology*; D008297:Male; D009298:Nasal Polyps / Q000139:chemically induced / Q000473:pathology*; D009362:Neoplasm Metastasis; D009602:Nitrosamines; D009669:Nose Neoplasms / Q000139:chemically induced / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D012727:Sex Characteristics
D009602:Nitrosamines