[Derivatives of arteannuin B with antileukemia activity].
Arteannuin B (I) was converted to hydroxy lactones (VII, VIII) by a mixture of formic acid and sulfuric acid. Compound VI and Compound VII both showed activity against leukemia P 388 cell in vitro. The rate of growth inhibition were 97.5% and 11.8% for (VI) and 80% and 52.6% for (VII) at the concentration of 10 and 1 micrograms/ml respectively. It seems that the antileukemia activity of 6-membered lactone is higher than that of 5-membered and the methylene group is necessary for the antileukemia activity.
Deng
D A
DA
Academia Sinica, Shanghai Institute of Materia Medica.
Xu
C H
CH
Cai
J C
JC
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology; D037621:Artemisinins; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D007941:Leukemia P388 / Q000473:pathology; D051379:Mice; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D037621:Artemisinins; D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes; C006634:arteannuin B