Stereotactic technique and pathophysiological mechanisms of neurotransplantation in Huntington's chorea.
In Huntington's chorea, embryonal brain tissue (striatum) was implanted in the caudate nucleus bilaterally, using stereotaxy assisted by CT. A special cannula allowed the placement into the brain of 3 or 4 grafts of embryonal tissue along the determined trajectory by one introduction of the cannula. The pathophysiological mechanism of neurotransplantation in Huntington's chorea is to compensate for the degenerated striatal tissue by embryonal striatum, so it is necessary to supply a quantity of embryonal striatal tissue which enables the whole functional integrity. Therefore, we use material from several embryos.
Sramka
M
M
Department of Stereotactic and Functional Neurosurgery, Institute of Preventive and Clinical Medicine, Bratislava, CSFR.
Rattaj
M
M
Molina
H
H
Vojtassák
J
J
Belan
V
V
Ruzický
E
E
D016380:Brain Tissue Transplantation / Q000295:instrumentation / Q000379:methods*; D003342:Corpus Striatum / Q000637:transplantation*; D016332:Fetal Tissue Transplantation / Q000295:instrumentation / Q000379:methods; D006801:Humans; D006816:Huntington Disease / Q000503:physiopathology* / Q000601:surgery*; D013238:Stereotaxic Techniques / Q000295:instrumentation