title: Treatment of T3 carcinoma of the larynx by surgery or radiotherapy.
abstract: T3 carcinoma of the larynx may be treated by surgery or by irradiation. A large number of oncologists feel that radical surgery offers a better chance of cure than does radiotherapy. We report a series of 147 patients with T3 N0 carcinoma of the larynx treated either by irradiation with salvage laryngectomy in the event of a recurrence, or by total laryngectomy. 109 patients had radiotherapy and 38 patients underwent surgery. The groups were well matched with no significant difference between the significant prognostic factors. The 5-year survival rate between the radiotherapy (70%) and surgery (40%) groups was significantly different (chi 2 = 4.48, d.f. = 1, P < 0.05). In spite of the well known problems associated with retrospective studies the present series suggests that radiotherapy combined with salvage surgery is an oncologically sound option for treating T3 laryngeal carcinoma.
authors.affiliation: Department of Otorhinolaryngology, University of Liverpool, UK.
authors.forename: A S
authors.initials: AS
authors.lastname: Jones
authors.forename: J A
authors.initials: JA
authors.lastname: Cook
authors.forename: D E
authors.initials: DE
authors.lastname: Phillips
authors.forename: E
authors.initials: E
authors.lastname: Soler Lluch
mesh_terms: D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate