Effect of styrene on testicular enzymes of growing rat.
Effect of styrene (100 or 200 mg/kg body wt/day) for 60 days was observed on testicular enzymes of postnatally maturing rats. A significant decrease in epididymal spermatozoa count was observed only at 200 mg/kg body weight dose. Activities of testicular sorbitol dehydrogenase and acid phosphatase decreased while activities of lactate dehydrogenase, beta-glucuronidase, glucose-6-phosphate dehydrogenase, and gamma-glutamyl transpeptidase significantly increased only in animals exposed to styrene at a dose of 200 mg/kg body weight. The results suggest that exposure to high dose of styrene during developmental period alters the activities of enzymes associated with specific cell type of testis.
Srivastava
S
S
Reproductive Toxicology Division, Industrial Toxicology Research Centre, Lucknow, India.
Seth
P K
PK
Srivastava
S P
SP
D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats; D017208:Rats, Wistar / Q000254:growth & development / Q000378:metabolism; D013076:Sperm Count / Q000187:drug effects; D020058:Styrene; D013343:Styrenes / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity*; D013737:Testis / Q000187:drug effects* / Q000201:enzymology* / Q000254:growth & development
D013343:Styrenes; D020058:Styrene