Biotransformation of the sympathomimetic tetraminol in vitro.
On incubation with the postmitochondrial fraction of the liver homogenate of rabbits, guinea-pigs, rats, and mice in the presence of NADPH and oxygen, the alpha-sympathomimetic trans-3-(2-hydroxyethylamino)-5,8-dimethoxy-1,2,3,4-tetrahydro-2-n aphthol (Tetraminol, 1) is preferentially O-demethylated in position 8, yielding metabolite 3. In male rats O-demethylation is stronger than in females.
Drandarov
K
K
Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Hradec Králové, Czechoslovakia.
Kvasnicková
E
E
Hais
I M
IM
D000818:Animals; D001711:Biotransformation; D002855:Chromatography, Thin Layer; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D051379:Mice; D011817:Rabbits; D051381:Rats; D013566:Sympathomimetics / Q000493:pharmacokinetics*; D013764:Tetrahydronaphthalenes / Q000493:pharmacokinetics*
D013566:Sympathomimetics; D013764:Tetrahydronaphthalenes; C024116:5,8-dimethoxy-2-(2-hydroxyethyl)amino-3-hydroxy-1,2,3,4-tetrahydronaphthalene