The anti-initiator action of p-methoxyphenol phosphate upon the transformation of normal human embryo cells induced by benzo(a)pyrene.
The association of p-methoxyphenol phosphate (10(-5)M) to benzo(a)pyrene treatment (10(-6)M) reduced significantly the anchorage independent growth and the number of transformed foci of the human embryo lung fibroblasts, after six passages from treatment application. Results from cytogenetic analysis show that p-methoxyphenol phosphate induced the decrease of numerical and structural chromosome aberration after the first passage of the treated cells. In terms of the results obtained by cytogenetic analysis the reduction of genetic instability seems to remain constant from the first to the sixth passage in the cell cultures treated with p-methoxyphenol phosphate associated to benzo(a)pyrene.
Găldean
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Institute of Oncology, Bucharest, Romania.
Petraşincu
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Stoicescu
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D000840:Anisoles / Q000494:pharmacology*; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001564:Benzo(a)pyrene / Q000037:antagonists & inhibitors* / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced / Q000187:drug effects*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000187:drug effects*; D006801:Humans; D008168:Lung
D000840:Anisoles; D016588:Anticarcinogenic Agents; D000975:Antioxidants; D001564:Benzo(a)pyrene; C009760:mequinol