title: [Microbial ecology of laboratory animals as a model in evaluation of the immunomodulating and antimicrobial agents].
abstract: Rats with altered microbial ecology and decreased colonization resistance due to neutropenia induced by cyclophosphamide were used as a model for estimating the effect of bacterial polysaccharides (lactulose and exopolysaccharide from Bacillus polymyxa) and fluoroquinolones (pefloxacin). Monotherapy with pefloxacin had a favourable effect both on normalization on the intestinal microflora in the rats and their hemopoiesis (decreased neutropenia). The highest correcting effect with respect to the lowered colonization resistance was observed when pefloxacin was used in combination with exopolysaccharide.
authors.forename: B A
authors.initials: BA
authors.lastname: Shenderov
authors.forename: E V
authors.initials: EV
authors.lastname: Glukhova
authors.forename: M M
authors.initials: MM
authors.lastname: Viadro
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D001407:Bacillus; D001422:Bacterial Adhesion / Q000187:drug effects / Q000502:physiology*; D001424:Bacterial Infections / Q000209:etiology / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D003092:Colitis / Q000209:etiology / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D003106:Colon / Q000187:drug effects / Q000276:immunology / Q000382:microbiology*; D003520:Cyclophosphamide; D004195:Disease Models, Animal; D008954:Models, Biological; D009503:Neutropenia / Q000139:chemically induced / Q000276:immunology*; D015366:Pefloxacin / Q000008:administration & dosage*; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000276:Adjuvants, Immunologic; D011135:Polysaccharides, Bacterial; D015366:Pefloxacin; D003520:Cyclophosphamide
vernacular_title: Mikrobnaia ékologiia laboratornykh zhivotnykh kak model' pri otsenke immunomoduliruiushchikh i antimikrobnykh agentov.