Nootropic candidates inhibit head-twitches induced by mescaline in mice.
The effects of various nootropic candidates on mescaline-induced head-twitches were studied in mice. The number of head-twitches induced by mescaline (100 mg/kg, s.c.) was significantly reduced by idebenone (32 and 100 mg/kg, i.p.), minaprine (0.32-10 mg/kg, p.o.) and nebracetam (100 mg/kg, p.o.). Cholinesterase inhibitors such as tetrahydroaminoacridine (1 and 10 mg/kg, p.o.), NIK-247 (10 and 18 mg/kg, p.o.) and physostigmine (0.32 mg/kg, i.p.) also suppressed the head-twitch response to mescaline. These results suggest that the direct or indirect cholinergic-activating effects of these drugs may be involved in inhibiting mescaline-induced head-twitches.
Yamamoto
T
T
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Ohno
M
M
Yatsugi
S
S
Fujikawa
Y
Y
Ueki
S
S
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D016227:Benzoquinones / Q000008:administration & dosage / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D008297:Male; D008635:Mescaline / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D011619:Psychotropic Drugs / Q000494:pharmacology*; D011724:Pyridazines / Q000008:administration & dosage / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000008:administration & dosage / Q000494:pharmacology*; D014451:Ubiquinone / Q000031:analogs & derivatives
D000928:Antidepressive Agents; D016227:Benzoquinones; D002800:Cholinesterase Inhibitors; D011619:Psychotropic Drugs; D011724:Pyridazines; D011760:Pyrrolidinones; C006149:minaprine; D014451:Ubiquinone; C036619:idebenone; D008635:Mescaline; C056640:nebracetam