title: Conjunctival involvement in paraneoplastic pemphigus.
abstract: Paraneoplastic pemphigus is a recently described autoimmune inflammatory mucocutaneous disease associated with an underlying neoplasm. Although histopathologic and direct immunofluorescence findings of involved skin and mucous membranes are consistent with pemphigus vulgaris, indirect immunofluorescence and immunoprecipitation study results are unique. We treated two patients with non-Hodgkin's lymphoma and paraneoplastic pemphigus. Both patients had bilateral bulbar conjunctival hyperemia and diffuse papillary tarsal conjunctival reactions. One patient had sloughing of conjunctival epithelium and the other had tarsal conjunctival cicatrization and forniceal shortening. Histopathologic findings of conjunctivae obtained from both patients were consistent with pemphigus vulgaris. Diffuse deposition of IgG and C3 in the intercellular substance of the conjunctival epithelium was demonstrated by direct immunofluorescence. Indirect immunofluorescence testing disclosed binding of autoantibodies to rodent bladder and intestinal epithelium. Immunoprecipitation disclosed antibodies reactive to Desmoplakin I (250 kd), bullous pemphigoid (230 kd), Desmoplakin II (210 kd) and 190-kd proteins. Ophthalmologists and pathologists should be aware of the conjunctival changes in paraneoplastic pemphigus.
authors.affiliation: Department of Ophthalmology, Cleveland Clinic Foundation, Ohio 44195-5024.
authors.forename: S J
authors.initials: SJ
authors.lastname: Meyers
authors.forename: G A
authors.initials: GA
authors.lastname: Varley
authors.forename: D M
authors.initials: DM
authors.lastname: Meisler
authors.forename: C
authors.initials: C
authors.lastname: Camisa
authors.forename: A H
authors.initials: AH
authors.lastname: Wander
mesh_terms: D000368:Aged; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology; D003176:Complement C3 / Q000032:analysis; D003228:Conjunctiva / Q000276:immunology; D003229:Conjunctival Diseases / Q000276:immunology / Q000473:pathology*; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D016393:Lymphoma, B-Cell / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000276:immunology / Q000473:pathology*; D010392:Pemphigus / Q000276:immunology / Q000473:pathology*
chemical_list: D003176:Complement C3; D007074:Immunoglobulin G