title: Multiple intragenic elements regulate the expression of the murine N-ras gene.
abstract: We have identified two separate regions within the murine N-ras transcription unit which may participate in the regulation of N-ras gene expression. One of these regions, localized to the first half of intron 1, contains a site of premature transcriptional arrest. We propose that premature transcription termination, which has been identified as an important control mechanism for several genes, may also play a role in the regulation of the N-ras gene. In addition, we have identified a positively acting region within the N-ras transcription unit. This region, localized to the end of intron 1/beginning of exon 1, was found to greatly increase expression from the N-ras promoter.
authors.affiliation: Department of Pathology, New York University Medical Center, New York 10016.
authors.forename: M
authors.initials: M
authors.lastname: Jeffers
authors.forename: A
authors.initials: A
authors.lastname: Pellicer
mesh_terms: D016475:3T3 Cells; D000818:Animals; D001483:Base Sequence; D015500:Chloramphenicol O-Acetyltransferase / Q000235:genetics; D005786:Gene Expression Regulation; D005809:Genes, Regulator; D011905:Genes, ras; D006168:Guinea Pigs; D006801:Humans; D007438:Introns; D051379:Mice; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D014158:Transcription, Genetic
chemical_list: D015500:Chloramphenicol O-Acetyltransferase