title: Studies on antimutagenic effect of milk cultured with lactic acid bacteria on the Trp-P2-induced mutagenicity to TA98 strain of Salmonella typhimurium.
abstract: The inhibitory effects of cultured milk using 76 strains of lactic acid bacteria isolated from milk products were investigated on the mutagenicity of 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P2), a tryptophan pyrolysate for Salmonella typhimurium TA98. Each cultured milk sample displayed its characteristic antimutagenic effect against the mutagenicity of Trp-P2. The milk cultured with Lactobacillus acidophilus LA106 (LA2) showed the highest inhibition of 82.1% among the strains used. Milk samples cultured with Lactococcus lactis subsp. lactis, Lll103 (10-3) and Lll102 (KM) also exhibited higher inhibition percentages.
authors.affiliation: Technical Research Laboratory, Takanashi Milk Products Co. Ltd. Yokohama, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hosoda
authors.forename: H
authors.initials: H
authors.lastname: Hashimoto
authors.forename: H
authors.initials: H
authors.lastname: Morita
authors.forename: M
authors.initials: M
authors.lastname: Chiba
authors.forename: A
authors.initials: A
authors.lastname: Hosono
mesh_terms: D000818:Animals; D016587:Antimutagenic Agents / Q000378:metabolism* / Q000494:pharmacology; D002243:Carbolines / Q000494:pharmacology*; D005285:Fermentation; D006863:Hydrogen-Ion Concentration; D007779:Lactobacillus acidophilus / Q000378:metabolism*; D013294:Lactococcus lactis / Q000378:metabolism*; D008892:Milk / Q000382:microbiology*; D009153:Mutagens / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects
chemical_list: D016587:Antimutagenic Agents; D002243:Carbolines; D009153:Mutagens; C019133:3-amino-1-methyl-5H-pyrido(4,3-b)indole