title: Activation of kinins on myocardial ischemia.
abstract: In experimental ischemic dog heart with coronary-constriction, no increase of coronary blood flow, Max dP/dt or MVO2 with no change of kinin in arterial blood were exhibited. Following sympathetic nerve stimulation, remarkable increases of kinin in coronary sinus blood were observed with a significant elevation of left ventricular end-diastolic pressure and an augmented production of lactate from the heart as well as an ischemic change of ECG-ST. Infusion of kinin into the left main coronary artery resulted in no change in the mean systemic blood pressure, coronary blood flow, coronary vascular resistance, cardiac function, myocardial metabolism or ECG-ST in the control and coronary-constricted groups. These data suggest that kinin was released significantly from the ischemic heart, however, such a level of kinin has no significant effect on coronary circulation or myocardial metabolism. In ischemia-reperfusion rabbit hearts, no significant influence of the ACE inhibitors, captopril and ramiprilat, were observed. Species differences may be responsible for the beneficial role of ACE inhibitors in the limitation of infarct size in the dog hearts, possessing collateral flow, that are not seen in the rabbit heart with poor collateral flow.
authors.affiliation: Second Department of Internal Medicine, Sapporo Medical College, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Shimamoto
authors.forename: T
authors.initials: T
authors.lastname: Miura
authors.forename: T
authors.initials: T
authors.lastname: Miki
authors.forename: O
authors.initials: O
authors.lastname: Iimura
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D004285:Dogs; D006321:Heart / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D007705:Kinins / Q000378:metabolism*; D009203:Myocardial Infarction / Q000188:drug therapy / Q000517:prevention & control; D017202:Myocardial Ischemia / Q000503:physiopathology*; D011817:Rabbits
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D007705:Kinins; D001920:Bradykinin