Rat model for a vascularized laryngeal allograft.
A new rat model was developed to reexamine the potential for laryngeal transplantation. The final anatomic derivation evolved from two earlier developmental phases. The first model had only a single arterial anastomosis; the second had an end-to-end arterial anastomosis with an end-to-end arteriovenous shunt. The final product employed an end-to-side arterial shunt and an end-to-side arteriovenous shunt for revascularization. The allografts were sited in tandem with the intact recipient larynges and were not innervated. A total of 16 animals were studied in phase 3; 2 died and the remaining 14 had a 64% arterial patency at intervals of 1 to 14 days. Our purpose is to detail the relevant technical considerations of this new model and compare it with historical controls.
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Joint Center for Otolaryngology, Brigham and Women's Hospital, Boston, Massachusetts.
Sloman-Moll
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E
Samonte
B R
BR
Wu
J
J
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M
D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D006085:Graft Survival; D007830:Larynx / Q000098:blood supply / Q000637:transplantation*; D051381:Rats; D017208:Rats, Wistar; D014184:Transplantation, Homologous / Q000379:methods; D014656:Vascular Surgical Procedures / Q000379:methods