title: The movement of solutes and cells across tight junctions.
abstract: The TJ is a highly dynamic rate-limiting barrier for passive transepithelial solute flow. It is not only physiologically regulated but is modulated in various disease states as well. Such modulations occur as a result of epithelial cell interactions with immune cells or immune cell products and thus epithelial barrier function appears to be regulated in disease states.
authors.affiliation: Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115.
authors.forename: J L
authors.initials: JL
authors.lastname: Madara
authors.forename: C
authors.initials: C
authors.lastname: Parkos
authors.forename: S
authors.initials: S
authors.lastname: Colgan
authors.forename: A
authors.initials: A
authors.lastname: Nusrat
authors.forename: K
authors.initials: K
authors.lastname: Atisook
authors.forename: P
authors.initials: P
authors.lastname: Kaoutzani
mesh_terms: D000038:Abscess / Q000378:metabolism; D000818:Animals; D006801:Humans; D007365:Intercellular Junctions / Q000378:metabolism* / Q000502:physiology; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000648:ultrastructure; D009504:Neutrophils / Q000502:physiology; D010539:Permeability