title: Is cerebral angiography indicated in infective endocarditis?
abstract: OBJECTIVE
  Patients with infective endocarditis may develop intracranial mycotic aneurysms. Whether these patients should undergo cerebral angiography followed by prophylactic surgery if an aneurysm is detected is an unresolved question.
  
  
  METHODS
  We estimated the probability of survival 12 weeks after the diagnosis of infective endocarditis on the basis of data available in the literature.
  
  
  RESULTS
  For a 40-year-old female patient with right-sided hemiplegia, the 12-week survival is estimated to be 83.75% without angiography and 83.65% with angiography; the specific mortality of intracranial mycotic aneurysms is relatively small but increases by 40% (from 0.25% to 0.35%) if angiography is performed. The risk of aneurysm rupture in infective endocarditis and the mortality from rupture appear to be the most important factors that affect the analysis.
  
  
  CONCLUSIONS
  Cerebral angiography should not be performed routinely in patients with infective endocarditis. Specific subgroups in whom such a policy might be beneficial have not yet been identified.
authors.affiliation: Center for Clinical Decision Sciences, Erasmus University, Rotterdam, The Netherlands.
authors.forename: J H
authors.initials: JH
authors.lastname: van der Meulen
authors.forename: W
authors.initials: W
authors.lastname: Weststrate
authors.forename: J
authors.initials: J
authors.lastname: van Gijn
authors.forename: J D
authors.initials: JD
authors.lastname: Habbema
mesh_terms: D000328:Adult; D000785:Aneurysm, Infected / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery; D002533:Cerebral Angiography; D004697:Endocarditis, Bacterial / Q000150:complications / Q000000981:diagnostic imaging* / Q000401:mortality; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery; D015995:Prevalence; D011336:Probability; D016019:Survival Analysis; D013997:Time Factors