Therapeutic potential of capsaicin-like molecules: studies in animals and humans.
Capsaicin-sensitive primary afferent neurons in the peripheral nervous system are widely distributed to both the somatic and visceral territories: their inactivation following capsaicin "desensitization" is expected to produce analgesia and to be useful for a number of human diseases such as asthma, urinary incontinence, inflammatory diseases of the gut, arthritis and psoriasis. The present communication reviews the therapeutic potential of capsaicin-like drugs in the pathophysiology of the mammalian urinary bladder.
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Pharmacology Department, A. Menarini Pharmaceuticals, Florence, Italy.
D000698:Analgesia; D000818:Animals; D002211:Capsaicin / Q000031:analogs & derivatives / Q000627:therapeutic use*; D003556:Cystitis / Q000188:drug therapy; D006801:Humans; D009475:Neurons, Afferent / Q000187:drug effects*; D010146:Pain / Q000188:drug therapy; D017288:Pain Threshold / Q000187:drug effects; D010525:Peripheral Nerves / Q000187:drug effects; D011955:Receptors, Drug / Q000502:physiology; D001743:Urinary Bladder / Q000294:innervation / Q000503:physiopathology; D014549:Urinary Incontinence / Q000188:drug therapy* / Q000503:physiopathology
D011955:Receptors, Drug; D002211:Capsaicin