title: Down-regulating effect on cellular immunity of the NSF17 factor produced by murine neonatal spleen cells fused with BW 5147 thymoma cells.
abstract: The non-specific factor NSF17 produced by mouse newborn splenocytes fused with BW 5147 thymoma cells was tested in vivo for its immunosuppressive activity. NSF17 administered i.p. in a single dose into adult mice significantly decreased the PHA-induced proliferative response of lymphocytes, regional graft-versus-host reaction, and delayed-type hypersensitivity.
authors.affiliation: Department of Immunobiology, Polish Academy of Sciences, Kraków.
authors.forename: M
authors.initials: M
authors.lastname: Bubak-Satora
authors.forename: O
authors.initials: O
authors.lastname: Machala
authors.forename: M
authors.initials: M
authors.lastname: Kubera
authors.forename: B
authors.initials: B
authors.lastname: Mazur-Kolecka
authors.forename: A
authors.initials: A
authors.lastname: Skowron-Cendrzak
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D006087:Graft vs Host Reaction / Q000276:immunology; D006825:Hybridomas; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D051379:Mice; D008808:Mice, Inbred CBA; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000276:immunology*; D013491:Suppressor Factors, Immunologic / Q000502:physiology*; D013945:Thymoma / Q000473:pathology
chemical_list: D013491:Suppressor Factors, Immunologic