Bacteremia in transplant recipients: a prospective study of demographics, etiologic agents, risk factors, and outcomes.
BACKGROUND
Bacteremic infections are a major cause of death among organ transplant recipients. We sought to identify the risk factors associated with death and examine the timing of the bacteremic episode after operation to recognize patients who may benefit from perioperative prophylactic antibiotic therapy.


METHODS
A total of 125 episodes of bacteremia or fungemia in 16 heart, 26 kidney, and 70 liver recipients were monitored prospectively in 1 year.


RESULTS
The urinary tract was the most frequent portal for kidney recipients, the gastrointestinal and biliary tracts were frequent for liver recipients, and the lung was frequent in heart recipients. Heart and liver recipients were more severely ill at the time of bacteremia and had bacteremia sooner after operation. Death at 14 days after onset of bacteremia was 33% in heart recipients, 24% in liver recipients, and 11% in kidney recipients. Risk of death was associated with the severity of the underlying condition of the transplant recipient, the source of the bacteremia, and the microbial agent. Pseudomonas aeruginosa and Enterobacter species had fatality rates of 47% and 63%, respectively. P. aeruginosa and Enterobacter were also most commonly associated with failures of perioperative antibiotic prophylaxis.


CONCLUSIONS
There are distinct clinical patterns of bacteremia in transplant recipients. The emergence of P. aeruginosa and Enterobacter species in the immediate postoperative period appeared to be a significant cause of morbidity and death among transplant recipients.
Wagener
M M
MM
Division of Infectious Disease, University of Pittsburgh School of Medicine, PA 15261.
Yu
V L
VL
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D003710:Demography; D016469:Fungemia / Q000453:epidemiology / Q000382:microbiology; D016027:Heart Transplantation; D006801:Humans; D016030:Kidney Transplantation; D016031:Liver Transplantation; D016377:Organ Transplantation / Q000401:mortality; D011183:Postoperative Complications; D011446:Prospective Studies; D012307:Risk Factors; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents