Linkage disequilibrium between DPA1 and DPB1 alleles among Norwegian Caucasoids and Japanese.
Associations between alleles at the DPA1 and DPB1 loci were analyzed in 181 Norwegian caucasoids. Associations were observed between the DPA1*0201 and the DPB1*0101, *0901, *1001 and *1101 alleles. An association between DPA1*0201 and the DPB1*0901 allele was also observed among 23 healthy Japanese and 24 Japanese MS patients. In addition, it appeared that among Japanese the DPA1*0201 allele may be associated to the DPB1*0501. In conclusion, alleles at the DPA1 and DPB1 loci display different associations among Norwegian caucasoids and Japanese.
Spurkland
A
A
Institute of Transplantation, Immunology, National Hospital, Oslo, Norway.
Vartdal
F
F
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D005802:Genes, MHC Class II; D006682:HLA-DP Antigens / Q000235:genetics*; D059867:HLA-DP alpha-Chains; D059868:HLA-DP beta-Chains; D006801:Humans; D007564:Japan; D015810:Linkage Disequilibrium; D008969:Molecular Sequence Data; D009103:Multiple Sclerosis / Q000235:genetics; D009664:Norway; D044465:White People / Q000235:genetics*
D006682:HLA-DP Antigens; D059867:HLA-DP alpha-Chains; D059868:HLA-DP beta-Chains; C071172:HLA-DPA1 antigen; C071170:HLA-DPB1 antigen