[Proteolytic mechanisms in bronchial secretions in rats with bronchial anaphylaxis].
Serine elastase-like proteinase was isolated from rat bronchial secretion, activity of which was increased 2-fold in bronchial anaphylaxis. Effect of histamine, serotonin and hydrocortisone on the enzymatic activity was studied. Regulation of the enzyme activity in bronchial anaphylaxis was considered with relation to patterns of its metabolism as well as depending on efficiency of specific endogenous inhibitor of the proteinase. A procedure for histamine stimulation of alkaline proteinase was developed.
Komov
V P
VP
Spasenkova
O M
OM
Strelkova
M A
MA
D000707:Anaphylaxis / Q000378:metabolism*; D000818:Animals; D001980:Bronchi / Q000201:enzymology / Q000378:metabolism*; D004789:Enzyme Activation; D006632:Histamine / Q000502:physiology; D006854:Hydrocortisone / Q000502:physiology; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D008297:Male; D051381:Rats; D012697:Serine Endopeptidases / Q000378:metabolism*; D012701:Serotonin / Q000502:physiology
D012701:Serotonin; D006632:Histamine; D012697:Serine Endopeptidases; D006854:Hydrocortisone
Issledovanie mekhanizmov proteoliza v bronkhial'nom sekrete u krys s bronkhial'noĭ anafilaksieĭ.