title: [Preclinical study of the general toxic effect of polyplatillen].
abstract: Toxic action of polyplatillen, a principally new platinum compound, was studied on laboratory animals and cell culture. When compared with cis-dichlorodiamminplatinum, the preparation is 10-fold less toxic in animals and 100-fold--in the cellular systems. Reversibility of damaging action of polyplatillen at "non-toxic" dosages conditions the perspectiveness of its further clinical trials.
authors.forename: S A
authors.initials: SA
authors.lastname: Shalimov
authors.forename: L V
authors.initials: LV
authors.lastname: Keĭsevich
authors.forename: E P
authors.initials: EP
authors.lastname: Trokhimenko
authors.forename: I V
authors.initials: IV
authors.lastname: Dziublik
authors.forename: I I
authors.initials: II
authors.lastname: Volchenskova
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002945:Cisplatin / Q000008:administration & dosage / Q000633:toxicity*; D004285:Dogs; D051379:Mice; D051381:Rats
chemical_list: D002945:Cisplatin
vernacular_title: Doklinicheskoe izuchenie obshchetoksicheskogo deĭstviia poliplatillena.