title: [Acute hepatic artery thrombosis in pediatric liver transplantation: surgical thrombectomy and in situ fibrinolysis].
abstract: In pediatric liver transplantation, hepatic artery thrombosis usually leads to graft loss, early due to hepatic necrosis when it occurs during the first week following the transplant procedure, or later due to biliary complications. Liver retransplantation is the usual attitude. However, urgent surgical hepatic arterial thrombectomy to restore the blood flow can be successful when early diagnosis is made with Doppler ultrasound examination and angiography. Four hepatic arterial thrombectomies were performed as an emergency with additional intra-hepatic arterial fibrinolytic treatment, in three children, 1.5, 3 and 5.5 years of age. Mean duration between the first signs of hepatic artery thrombosis and thrombectomy was 16 hours. None of the children had an urgent liver retransplantation. A complete success was obtained in one case, with normal liver function tests and patent hepatic artery on the Doppler ultrasound examination at the present time. In the two other cases, hepatic artery thrombosis recurred, in spite of repeated thrombectomy in one case; following this attempt complications of hepatic artery thrombosis occurred in the two patients: ischemic necrosis of the left lobe (1 case), biliary leak (1 case) and stenosis of the common bile duct (2 cases). A complete success in one case and a partial success in the two others lead us to advocate urgent thrombectomy and in situ fibrinolytic treatment when early diagnosis of hepatic artery thrombosis is made.
authors.affiliation: Clinique Chirurgicale, Hôpital Cochin, Paris.
authors.forename: P O
authors.initials: PO
authors.lastname: Sarfati
authors.forename: O
authors.initials: O
authors.lastname: Boillot
authors.forename: F
authors.initials: F
authors.lastname: Baudin
authors.forename: J
authors.initials: J
authors.lastname: Laurent
authors.forename: D
authors.initials: D
authors.lastname: Houssin
authors.forename: Y
authors.initials: Y
authors.lastname: Chapuis
mesh_terms: D000208:Acute Disease; D000792:Angiography; D001027:Aortography; D002675:Child, Preschool; D005260:Female; D005342:Fibrinolysis; D006499:Hepatic Artery / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007223:Infant; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D017131:Thrombectomy / Q000379:methods*; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology / Q000601:surgery*; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D014568:Urokinase-Type Plasminogen Activator
vernacular_title: Thromboses aiguës de l'artère hépatique en transplantation hépatique pédiatrique: désobstruction chirurgicale et fibrinolyse in situ.