Regulation of bradykinin-induced chloride secretion in a human epithelial cell line.
The chloride secretory response to bradykinin in T84 cells is regulated. The efflux rate of 125I from these cells can be used to measure this response, and to demonstrate that the sensitivity to bradykinin varies with time in culture. The response in NuT84 cells is greater than that in T84, and can be blocked by the B2 receptor antagonist HOE-140.
Miller
D H
DH
Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston.
Baird
A W
AW
Bennet
S
S
Halushka
M
M
Sasaguri
M
M
Schomer
H
H
Margolius
H S
HS
D001920:Bradykinin / Q000494:pharmacology*; D002460:Cell Line; D002712:Chlorides / Q000378:metabolism*; D005576:Colforsin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007454:Iodides / Q000378:metabolism; D007457:Iodine Radioisotopes; D007700:Kinetics
D002712:Chlorides; D007454:Iodides; D007457:Iodine Radioisotopes; D005576:Colforsin; D001920:Bradykinin