The use of microcomputer-based psychomotor tests for the evaluation of benzodiazepine effects on human performance: a review with emphasis on temazepam.
1. The literature relating to the effects of benzodiazepines in general, and temazepam in particular, on human psychomotor performance as assessed using microcomputer-based testing batteries is surveyed. 2. The adverse effects of central nervous system depressants on performance is an important mediocolegal issue and frequently comes into question in on-the-road and on-the-job accidents. The use of microcomputer-based testing batteries allows for performance evaluation both in the laboratory and at-the-scene, as well as providing the opportunity to model a large number of different behaviours required in routine yet complex psychomotor tasks. 3. The conclusions in general are: (1) The benzodiazepines as a class of drugs impair both cognitive and motor performance. These effects are often subtle when low doses are involved or when testing occurs the morning following evening administration of the medication. (2) No single psychomotor task adequately simulates complex daily tasks such as automobile driving. A battery of tests that evaluates a number of the components of such tasks is necessary to determine adequately the full range of effects of these medications.
Kunsman
G W
GW
Department of Pharmacology, Louisiana State University Medical Center, Shreveport 71130-3932.
Manno
J E
JE
Manno
B R
BR
Kunsman
C M
CM
Przekop
M A
MA
D001569:Benzodiazepines / Q000009:adverse effects; D002986:Clinical Trials as Topic; D004341:Drug Evaluation / Q000379:methods; D006801:Humans; D008838:Microcomputers; D011597:Psychomotor Performance / Q000187:drug effects*; D013693:Temazepam / Q000009:adverse effects*
D001569:Benzodiazepines; D013693:Temazepam