title: A localized pleuropulmonary lesion induced by long-term therapy with amiodarone.
abstract: Pulmonary toxicity is an important adverse effect of amiodarone therapy that usually manifests as an acute or chronic diffuse lung disease; in rare cases localized lesions have also been described. We observed a solitary mass localized in the left lung base and involving the adjacent pleura in a 69-year-old man who had been treated for 1 year with amiodarone (cumulative dose 52 g). Cytological and histological examination showed that the lesion consisted of fibrotic tissue and a massive macrophagic infiltration. Following suspension of amiodarone and surgical excision, there was a complete recovery and the mass did not relapse. We confirm that respiratory complaints can occur in patients treated by long-term amiodarone therapy and that lung involvement can manifest with a solitary localized (fibrotic) lesion.
authors.affiliation: Department of Internal Medicine, Hospital of San Donà di Piave, Venice, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Piazza
authors.forename: N
authors.initials: N
authors.lastname: Bizzaro
mesh_terms: D000368:Aged; D000638:Amiodarone / Q000009:adverse effects*; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008171:Lung Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D010994:Pleura / Q000000981:diagnostic imaging; D010995:Pleural Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D000638:Amiodarone