Crossover trials comparing several treatments.
Designs exist for crossover studies in which the possibility of distortion by carryover effects is minimised. A novel design including 5 treatments and 15 subjects with this property is presented, along with existing designs. These designs incorporating balance for carryover effects should be used in preference to cyclical permutation designs. Statistical analysis of the resulting data is readily performed.
Newcombe
R G
RG
Department of Medical Computing and Statistics, University of Wales College of Medicine, Cardiff, UK.
D000704:Analysis of Variance; D002986:Clinical Trials as Topic / Q000379:methods*; D003773:Dental Plaque / Q000188:drug therapy / Q000517:prevention & control; D006801:Humans; D009910:Oral Hygiene; D011897:Random Allocation; D015983:Selection Bias