title: Determination of tissue kallikrein and alpha 1-antitrypsin-tissue kallikrein complexes in synovial fluid of patients with rheumatoid, osteo and psoriatic arthritis.
abstract: An enzyme-linked immunosorbant assay was developed to determine tissue kallikrein and alpha 1-antitrypsin-tissue kallikrein complexes in pooled synovial fluid of patients with rheumatoid, osteo and psoriatic arthritis. Even though basal values could be determined, the addition of synovial fluid shifted the standard curves for both tissue kallikrein and alpha 1-antitrypsin-tissue kallikrein complex to the right, because of the presence of a novel inhibitor.
authors.affiliation: Department of Pharmacology, School of Medical Sciences, University of Bristol.
authors.forename: M M
authors.initials: MM
authors.lastname: Rahman
authors.forename: K
authors.initials: K
authors.lastname: Worthy
authors.forename: C J
authors.initials: CJ
authors.lastname: Elson
authors.forename: P A
authors.initials: PA
authors.lastname: Dieppe
authors.forename: K D
authors.initials: KD
authors.lastname: Bhoola
mesh_terms: D015535:Arthritis, Psoriatic / Q000097:blood / Q000378:metabolism* / Q000652:urine; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000378:metabolism* / Q000652:urine; D006801:Humans; D007610:Kallikreins / Q000378:metabolism*; D007700:Kinetics; D046911:Macromolecular Substances; D010003:Osteoarthritis / Q000097:blood / Q000378:metabolism* / Q000652:urine; D012463:Saliva / Q000378:metabolism; D013582:Synovial Fluid / Q000737:chemistry / Q000201:enzymology / Q000378:metabolism*; D020840:Tissue Kallikreins; D000515:alpha 1-Antitrypsin / Q000378:metabolism*
chemical_list: D046911:Macromolecular Substances; D000515:alpha 1-Antitrypsin; D007610:Kallikreins; D020840:Tissue Kallikreins