title: Changes in immunologic response in tonsillectomized children. I. Immunosuppression in recurrent tonsillitis.
abstract: The possible immunoregulatory role of the tonsils was studied by determining immunoglobulins IgG, A, M, E and factors C'3, C'4 and PFB of the complement system before and after tonsillectomy. The synthesis in vitro of IgG and IgM by lymphocytes stimulated with pokeweed mitogen was also measured. There were statistically significant differences between pre and post-operative levels of serum IgG, IgA and IgM, which decreased after surgery. Practically no change in the mean values of IgE and no significant differences in the levels of serum C'3, C'4, and PFB, were found. The in-vitro synthesis of both immunoglobulins (IgG, IgM) by lymphocytes increased significantly after tonsillectomy. Our results suggest that not only does tonsillectomy have no counterproductive effect on the immune system, but that, on the contrary, it seems to improve the immune response, since it appears to unblock the suppression to which the immune system was subject.
authors.affiliation: Departamento de ORL, Hospital Universitario de Granada, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Sainz
authors.forename: F
authors.initials: F
authors.lastname: Gutierrez
authors.forename: P M
authors.initials: PM
authors.lastname: Moreno
authors.forename: C
authors.initials: C
authors.lastname: Muñoz
authors.forename: M
authors.initials: M
authors.lastname: Ciges
mesh_terms: D002648:Child; D002675:Child, Preschool; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D011415:Complement Factor B / Q000032:analysis; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D011182:Postoperative Care; D011300:Preoperative Care; D012008:Recurrence; D014068:Tonsillectomy; D014069:Tonsillitis / Q000097:blood / Q000276:immunology* / Q000601:surgery
chemical_list: D003176:Complement C3; D003181:Complement C4; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007073:Immunoglobulin E; D011415:Complement Factor B