title: Fluorocarbon 113 exposure and cardiac dysrhythmias among aerospace workers.
abstract: We investigated the cardiotoxic effects of 1,1,2-Trichloro-1,2,2- Trifluoroethane (fluorocarbon 113 or FC113) exposures among healthy workers cleaning rocket and ground support equipment for the National Aeronautic and Space Administration (NASA) programs. Exposure and ambulatory electrocardiographic (ECG) monitoring data were evaluated on 16 workers, each of whom was examined on exposed and nonexposed workdays. We examined whether there was a greater rate of dysrhythmias on an exposed workday relative to a nonexposed workday. Overall, we found no within subject differences in the rate of ventricular and supraventricular premature beats (number per 1,000 heart beats), fluctuations in the length of the P-R interval, or heart rate. We found that levels of FC113 exposures below the Occupational Safety and Health Administration (OSHA) 8-hour time-weighted-average (TWA) standard of 1,000 ppm did not induce cardiac dysrhythmias or subtle changes in cardiac activity. However, because fluorocarbons may sensitize the heart to epinephrine, this study's negative findings based on sedentary and fairly healthy workers may not be generalizable to other populations of workers who are not as healthy or engaged in more physically demanding work.
authors.affiliation: National Institute for Occupational Safety and Health, Industrywide Studies Branch, Cincinnati, OH 45226.
authors.forename: G M
authors.initials: GM
authors.lastname: Egeland
authors.forename: T F
authors.initials: TF
authors.lastname: Bloom
authors.forename: T M
authors.initials: TM
authors.lastname: Schnorr
authors.forename: R W
authors.initials: RW
authors.lastname: Hornung
authors.forename: A J
authors.initials: AJ
authors.lastname: Suruda
authors.forename: K K
authors.initials: KK
authors.lastname: Wille
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000175:diagnosis; D064227:Chlorofluorocarbons, Ethane; D005617:Chlorofluorocarbons, Methane / Q000009:adverse effects*; D015716:Electrocardiography, Ambulatory; D005260:Female; D006801:Humans; D008297:Male; D016273:Occupational Exposure; D013026:Space Flight
chemical_list: D064227:Chlorofluorocarbons, Ethane; D005617:Chlorofluorocarbons, Methane; C005850:1,1,1-trichloro-2,2,2-trifluoroethane