title: Development of continuous recirculating peritoneal dialysis using a double lumen catheter.
abstract: Continuous recirculating peritoneal dialysis (CRPD) was newly introduced to improve solute removal efficiency in conventional dialysis therapies such as hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD). In CRPD, a part of the dialysate in the peritoneal cavity was drained through a double-lumen catheter and purified by an extracorporeal dialyzer. Urea removal characteristics in CRPD were examined in a canine study. In this study, a recirculation-dialysis experiment using a dog weighing 9.0 kg was carried out under 100 and 200 ml/min of flow for recirculating and delivered dialysates, respectively. An FB-50H (Nipro Medical Industries, Ltd., Osaka, Japan) composed of cellulose diacetate membrane with 0.5 m2 of surface area and Dianeal-1.5 (Baxter Limited Laboratories, Tokyo, Japan) containing urea were used as the extracorporeal dialyzer and dialysate. Urea peritoneal and dialyzer dialysances (DBP and DBD) were 3.05 and 33.3 ml/min by computer simulation using a compartment model for CRPD. This DBP value can be estimated as 20.3 ml/min for a 60 kg human. From this result, time-averaged value for BUN over an 8 hr/day CRPD, combined with three exchanges/day as CAPD is estimated to be 34.3 mg/dl, which is much lower than 45.2 mg/dl for a 12 hr/week HD, or 53.0 mg/dl for conventional CAPD.
authors.affiliation: Kidney Center, Tokyo Women's Medical College, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Mineshima
authors.forename: M
authors.initials: M
authors.lastname: Watanuki
authors.forename: K
authors.initials: K
authors.lastname: Yamagata
authors.forename: K
authors.initials: K
authors.lastname: Era
authors.forename: S
authors.initials: S
authors.lastname: Nakazato
authors.forename: H
authors.initials: H
authors.lastname: Suga
authors.forename: T
authors.initials: T
authors.lastname: Agishi
authors.forename: K
authors.initials: K
authors.lastname: Ota
authors.forename: K
authors.initials: K
authors.lastname: Sakai
authors.forename: K
authors.initials: K
authors.lastname: Fukui
mesh_terms: D000818:Animals; D002404:Catheterization / Q000295:instrumentation; D004285:Dogs; D005069:Evaluation Studies as Topic; D007700:Kinetics; D015233:Models, Statistical; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000295:instrumentation* / Q000379:methods; D014508:Urea / Q000378:metabolism
chemical_list: D014508:Urea