Effects of a long-chain fatty amine on mammary carcinogenesis induced in female Sprague-Dawley rats by DMBA.
Reports that protein kinase C is inhibited by sphingosine and other long-chain amines and the suggestion that promotion of mammary carcinogenesis by dietary fat is mediated by protein kinase C prompted us to investigate the effects of a long-chain amine, 1-octadecylamine, on mammary carcinogenesis induced by 7,12-dimethylbenz[a]anthracene in rats fed a high-fat diet. Rats fed the amine sulfate at a level of 0.01% in a semipurified diet containing 20% corn oil developed more tumors than those fed the high-fat diet alone, although body weight gain was inhibited slightly. Rats fed the amine sulfate at 0.1% of the diet developed very few tumors compared with those fed either the high-fat diet or a low-fat diet containing 5% corn oil. At the higher level, the C18 amine also caused a marked inhibition of body weight gain.
Parenteau
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H
Department of Biochemistry, University of Western Ontario, London, Canada.
Ho
T F
TF
Eckel
L A
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Carroll
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KK
D015127:9,10-Dimethyl-1,2-benzanthracene; D000588:Amines / Q000633:toxicity*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003314:Corn Oil / Q000633:toxicity; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000201:enzymology*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D000588:Amines; D015127:9,10-Dimethyl-1,2-benzanthracene; D003314:Corn Oil; D011493:Protein Kinase C; C009317:stearylamine