[Influence of normovolemic hemodilution on organ blood flow].
The normovolemic hemodilution was carried out in adult mongrel dogs by using SALIN-HES, and organ blood flow was measured by hydrogen clearance method, and the distribution rate of cardiac output to the organ was calculated. The organ blood flow was measured in the cerebral cortex (CCBF), liver (LBF) and renal cortex (RCBF). The hematocrit level before hemodilution was 42%. The subsequent hematocrit levels (at 4 stages) were 26% at S1, 18% at S2, 10% at S3 and 5% at S4. The results suggest that higher the degree of hemodilution, CCBF increases more, and that CCBF increased significantly from S2 to S4. However, no significant variation was observed in the distribution rates of the blood flow. Moreover, no significant variation by hemodilution was also observed in both LBF and RCBF. However, a significant decrease of the distribution rate of the blood flow was observed in LBF from S1 to S2 and RCBF from S2 to S4, and the higher the degree of the hemodilution is, the rate of blood flow decreased the more remarkably.
Kobori
M
M
Department of Anesthesiology, School of Medicine, Showa University, Tokyo.
Negishi
H
H
Hosoyamada
A
A
D000818:Animals; D001810:Blood Volume / Q000502:physiology*; D002540:Cerebral Cortex / Q000098:blood supply*; D004285:Dogs; D006438:Hemodilution; D007672:Kidney Cortex / Q000098:blood supply*; D008099:Liver / Q000098:blood supply*