title: Exposure to ozone and erythrocyte osmotic resistance in the rat.
abstract: In order to learn the biological effect of photochemical oxidants on living bodies, we exposed newborn and adult rats, of both sexes, to ozone at a concentration of 0.25 ppm, which can be encountered in an urban environment, and then measured the osmotic resistance of their erythrocytes. The results of experiments using newborn rats indicated a positive increase in the osmotic resistance of erythrocytes in whole blood following ozone exposure for 4 weeks. An increase in the osmotic resistance of erythrocytes in the top part obtained by centrifugation was observed following ozone exposure for 12 weeks. This tendency was especially evident among male rats. On the other hand, no increase in the osmotic resistance of erythrocytes was recognized in the adult animals which had been exposed to the same concentration of ozone for 18 months.
authors.affiliation: Department of Hygiene, Yokohama City University school of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ikemi
authors.forename: K
authors.initials: K
authors.lastname: Ohmori
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: F
authors.initials: F
authors.lastname: Osaka
authors.forename: Y
authors.initials: Y
authors.lastname: Matuura
mesh_terms: D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D004910:Erythrocyte Membrane / Q000187:drug effects*; D005260:Female; D006461:Hemolysis / Q000187:drug effects; D008297:Male; D009995:Osmosis; D010126:Ozone / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012737:Sex Factors
chemical_list: D010126:Ozone