[Synthesis of thieno(3,3-d)- and -(3,4-d)pyrimidines by alternative ring closure reactions].
3-Acetylamino-substituted thiophene with cyano and carboxylic acid methylester group in 2- and 4-position react with primary amines to give thieno(3,2-d)- or thieno(3,4)-dpyrimidines. Furthermore thieno(3,4-d)-pyrimidines were prepared from non-acetylated thiophene derivatives. Some thienopyrimidines showed antiulcer antiallergic effects, respectively.
Briel
D
D
Universitat Leipzig, Lehrstuhl Pharmezuetische Chemie, Germany.
Maschke
T
T
Wagner
G
G
D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006633:Histamine Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013056:Spectrophotometry, Ultraviolet; D013276:Stomach Ulcer / Q000517:prevention & control
D000897:Anti-Ulcer Agents; D006633:Histamine Antagonists; D011743:Pyrimidines
Synthese von Thieno(3,3-d)- und -(3,4-d)pyrimidinen durch alternative Ringschlussreaktionen.