title: Evaluation of experimental early acute cerebral ischemia before the development of edema: use of dynamic, contrast-enhanced and diffusion-weighted MR scanning.
abstract: The ability of dynamic, contrast-enhanced, magnetic susceptibility-weighted scanning to delineate early experimental acute cerebral infarction was compared with that of heavily T2-weighted and diffusion-weighted spin echo scanning. Spontaneously hypertensive rats, which had undergone right middle cerebral artery occlusion, were studied from 15 min to 3 h post ligation on a 1.5-T clinical whole-body imager. In contrast to the diffusion- and T2-weighted spin echo scans, the dynamic, contrast-enhanced technique clearly and consistently delineated the nonperfused regions as early as 15 min post ligation.
authors.affiliation: Department of Radiology, University Hospitals of Cleveland/Case Western Reserve School of Medicine, Ohio 44106.
authors.forename: D A
authors.initials: DA
authors.lastname: Finelli
authors.forename: A L
authors.initials: AL
authors.lastname: Hopkins
authors.forename: W R
authors.initials: WR
authors.lastname: Selman
authors.forename: R C
authors.initials: RC
authors.lastname: Crumrine
authors.forename: S U
authors.initials: SU
authors.lastname: Bhatti
authors.forename: W D
authors.initials: WD
authors.lastname: Lust
mesh_terms: D000208:Acute Disease; D000818:Animals; D001929:Brain Edema / Q000175:diagnosis*; D002545:Brain Ischemia / Q000175:diagnosis*; D003287:Contrast Media; D003911:Dextrans; D004338:Drug Combinations; D052203:Ferrosoferric Oxide; D005682:Gadolinium; D019786:Gadolinium DTPA; D007501:Iron; D008279:Magnetic Resonance Imaging / Q000379:methods; D058185:Magnetite Nanoparticles; D008536:Meglumine; D009942:Organometallic Compounds; D010087:Oxides; D004369:Pentetic Acid; D011107:Polylysine / Q000031:analogs & derivatives; D051381:Rats; D011918:Rats, Inbred SHR; D013997:Time Factors
chemical_list: D003287:Contrast Media; D003911:Dextrans; D004338:Drug Combinations; D058185:Magnetite Nanoparticles; D009942:Organometallic Compounds; D010087:Oxides; C068674:polylysine-(Gd-DTPA); D011107:Polylysine; D008536:Meglumine; D004369:Pentetic Acid; D005682:Gadolinium; D007501:Iron; C065507:ferumoxides; D019786:Gadolinium DTPA; D052203:Ferrosoferric Oxide