[The morphofunctional parallels in arterial hypertension in patients with chronic glomerulonephritis].
The restructure of renal tissue in intravital nephric biopsy specimens, renin-angiotensin-aldosterone together with kallikrein synthetic functions were studied and compared in patients with mesangioproliferative and membranoproliferative glomerulonephritis (MsPGN and MPGN). The characteristics of the morphological changes were defined. In MsPGN with secondary hypertension (SH), nephronic wasting and hyalinosis of arteries were mostly detectable whereas MPGN with SH was primarily marked by the derangement of the tubulointerstitial structures. In MPGN, the levels of total and inactive renin (TR and IR) were significantly higher than in MsPGN. This can be regarded as risk factor of early development of SH. The content of TR and IR and in addition that of active renin (AR) in MRGN did not depend on the clinical form of chronic glomerulonephritis. As compared to MsPGN with an isolated urinary syndrome, in MsPGN with SH, AR was prevalent, while its level correlated well with systolic and the mean arterial pressure. AR may be implicated in the mechanism of SH in MsPGN. In MPGN with SH, kallikreinuria was found to be extremely low, which may be consequent to tubulointerstitial injuries. The discoordination of the renin-angiotensin and kallikrein system may be one of the causes of earlier formation and the grave course of SH in the morphological pattern under consideration.
Riabov
S I
SI
Gadaev
A
A
Kotovoĭ
Iu O
IuO
Kucher
A G
AG
Degtereva
O A
OA
Kaiukov
I G
IG
D000328:Adult; D000450:Aldosterone / Q000097:blood; D002908:Chronic Disease; D005921:Glomerulonephritis / Q000097:blood / Q000503:physiopathology* / Q000652:urine; D015432:Glomerulonephritis, Membranoproliferative / Q000097:blood / Q000503:physiopathology / Q000652:urine; D015433:Glomerulonephritis, Membranous / Q000097:blood / Q000503:physiopathology / Q000652:urine; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology* / Q000652:urine; D007610:Kallikreins / Q000652:urine; D007668:Kidney / Q000503:physiopathology*; D012083:Renin / Q000097:blood
D000450:Aldosterone; D007610:Kallikreins; D012083:Renin
Morfofunktsional'nye paralleli pri arterial'noĭ gipertensii u bol'nykh khronicheskim glomerulonefritom.