Plasma levels of the anaphylatoxins C3a and C4a in patients with IgA nephropathy/Henoch-Schönlein nephritis.
Measurements of plasma anaphylatoxins C3a and C4a were carried out as an indicator of in vivo complement activation in 46 patients suffering from IgA nephropathy/Henoch-Schönlein nephritis. There was a significant correlation between plasma levels of C4a and plasma creatinine and urea. We also found a significant correlation of plasma levels of C3a with plasma creatinine. We propose that the measurement of anaphylatoxin levels provides a sensitive indicator of in vivo complement activation and may serve as an additional method for monitoring the progress of disease in these patients.
Abou-Ragheb
H H
HH
Department of Immunology, Royal Hallamshire Hospital, Sheffield, UK.
Williams
A J
AJ
Brown
C B
CB
Milford-Ward
A
A
D000328:Adult; D002940:Circadian Rhythm; D015926:Complement C3a / Q000032:analysis*; D015934:Complement C4a / Q000032:analysis*; D003404:Creatinine / Q000097:blood; D005260:Female; D005922:Glomerulonephritis, IGA / Q000097:blood*; D006801:Humans; D011695:IgA Vasculitis / Q000097:blood / Q000150:complications; D008297:Male; D008875:Middle Aged; D009393:Nephritis / Q000097:blood* / Q000209:etiology; D011507:Proteinuria / Q000097:blood; D014508:Urea / Q000097:blood
D015926:Complement C3a; D015934:Complement C4a; D014508:Urea; D003404:Creatinine