title: IgG antibodies to Loxosceles sp. spider venom in human envenoming.
abstract: The presence and specificity of IgG antibodies produced by patients with loxoscelism were studied. The loxoscelism diagnosis was supported mainly by clinical parameters. A search for IgG antibodies anti-Loxosceles gaucho venom in patients with loxoscelism submitted to serumtherapy showed antibodies in four out of 20 patients. The IgG antibodies were detected as early as 9 days and as late as 120 days after bite. The highest IgG antibody titer was 1:640 and the lowest was 1:80. Immunoblotting tests showed that human anti-L. gaucho IgG antibodies recognize preferentially the components responsible for the dermonecrotic and lethal activities of the venom. A comparison of the clinical picture, the level of serum IgG antibodies and the dose of antivenom administered suggest that there is no relationship between these parameters.
authors.affiliation: Centro de Pesquisa e Formação em Imunologia, Instituto Butantan, São Paulo, Brazil.
authors.forename: K C
authors.initials: KC
authors.lastname: Barbaro
authors.forename: J L
authors.initials: JL
authors.lastname: Cardoso
authors.forename: V R
authors.initials: VR
authors.lastname: Eickstedt
authors.forename: I
authors.initials: I
authors.lastname: Mota
mesh_terms: D000997:Antivenins / Q000276:immunology*; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D015151:Immunoblotting; D007074:Immunoglobulin G / Q000276:immunology*; D001098:Spider Bites / Q000276:immunology*; D013111:Spider Venoms / Q000276:immunology*
chemical_list: D000997:Antivenins; D007074:Immunoglobulin G; D013111:Spider Venoms