title: Indomethacin and sodium carbonate effects on conditioned fever and NK cell activity.
abstract: The augmentation of natural killer (NK) cell activity and elevation of body temperature (fever) can both be conditioned using camphor odor as the conditioned stimulus (CS) and poly I:C as the unconditioned stimulus (US). While both responses can be conditioned in parallel fashion as shown previously, our results indicate the conditioned learning of these responses may not follow along a common path. We found that injection of a 1% solution of sodium carbonate was able to consistently block the CS/US learning of the NK cell response but did not block conditioning of the fever response. In contrary fashion, mice treated with indomethacin (which inhibits prostaglandin-induced fever) dissolved in the sodium carbonate solution did not learn in consistent fashion the fever response. However, indomethacin-treated animals were able to recall the NK cell response. These results support the view that although the same mediator, IFN-beta, is responsible for the conditioned learning of the NK cell and fever responses both the learning and recall of the responses are initiated along separate pathways.
authors.affiliation: Department of Microbiology, University of Alabama, Birmingham 35294.
authors.forename: C
authors.initials: C
authors.lastname: Rogers
authors.forename: V
authors.initials: V
authors.lastname: Ghanta
authors.forename: C M
authors.initials: CM
authors.lastname: Hsueh
authors.forename: N
authors.initials: N
authors.lastname: Hiramoto
authors.forename: R
authors.initials: R
authors.lastname: Hiramoto
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002254:Carbonates / Q000494:pharmacology*; D003213:Conditioning, Psychological / Q000187:drug effects*; D005260:Female; D005334:Fever / Q000523:psychology*; D007213:Indomethacin / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000166:cytology / Q000187:drug effects
chemical_list: D002254:Carbonates; C005686:sodium carbonate; D007213:Indomethacin