Detection and assignment of the glucose signal in 1H NMR difference spectra of the human brain.
The difference between 1H NMR spectra obtained during eu- and hyperglycemia exhibited well-resolved glucose peaks between 3 and 4 ppm as demonstrated by comparison with solution spectra. Estimated increases were consistent with recent 13C NMR quantitations of intracerebral glucose. Difference spectra were measured in 36-ml volumes from the human brain every 3 min.
Gruetter
R
R
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06510.
Rothman
D L
DL
Novotny
E J
EJ
Shulman
G I
GI
Prichard
J W
JW
Shulman
R G
RG
D001923:Brain Chemistry; D005947:Glucose / Q000032:analysis*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods
D005947:Glucose