title: Preliminary studies on the in vitro and in vivo effect of salicylate on sperm motility.
abstract: We have studied the in vitro effect of different concentrations of salicylic acid on the motility of normal human spermatozoa. Sperm motility was evaluated over 48 h at 0, 50, 100, and 200 mg/L of salicylate concentrations. Results are reported as the mean % motility, where 100% motility at each time interval was taken to be the motility of the control (0 mg/L of salicylate). At 48 h, the mean % motility (n = 12) was 61, 43, and 33% at 50, 100, and 200 mg/L of salicylate. Twenty-four-hour values (n = 17) were 75, 65, and 48%. Eosin supravital staining demonstrated that the decrease in sperm motility was caused by direct inhibition of motility rather than by spermatozoal death. Four healthy males (17-51 years of age) gave a semen specimen prior to taking 650 mg of salicylate four times daily, followed by a second semen specimen 72 h later. Each individual, therefore, served as his own control. The mean % motility in the postdrug sample at 2, 24, and 48 h was 49, 53, and 47% of the motility found in the predrug sample (n = 4). We conclude that salicylate significantly decreases sperm motility in vitro and in vivo.
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Columbia Hospital for Women Medical Center, Washington, D.C.
authors.forename: O
authors.initials: O
authors.lastname: Porat-Soldin
authors.forename: S J
authors.initials: SJ
authors.lastname: Soldin
mesh_terms: D000293:Adolescent; D000328:Adult; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D008875:Middle Aged; D012459:Salicylates / Q000494:pharmacology*; D020156:Salicylic Acid; D013081:Sperm Motility / Q000187:drug effects*
chemical_list: D012459:Salicylates; D020156:Salicylic Acid