title: Acetazolamide in hemodialysis patients: a rational use after ocular surgery.
abstract: Acetazolamide is a weak diuretic used to decrease production of aqueous humor in the eye. Hemodialysis patients undergoing ocular surgery may benefit from acetazolamide; however, no pharmacokinetic data are available for this group of patients. We report a patient who received acetazolamide 250 mg every 6 hours after ophthalmic surgery and developed reversible neurological side effects associated with very high plasma concentrations. Using pharmacokinetic analysis, we suggest an alternate administration of acetazolamide for end-stage renal patients.
authors.affiliation: Department of Medicine, Hôpital Saint-Luc, Montréal, Quebec, Canada.
authors.forename: L F
authors.initials: LF
authors.lastname: Roy
authors.forename: L R
authors.initials: LR
authors.lastname: Dufresne
authors.forename: L
authors.initials: L
authors.lastname: Legault
authors.forename: H
authors.initials: H
authors.lastname: Long
authors.forename: C
authors.initials: C
authors.lastname: Morin
mesh_terms: D000086:Acetazolamide / Q000009:adverse effects* / Q000097:blood / Q000493:pharmacokinetics; D000328:Adult; D001921:Brain / Q000187:drug effects*; D003221:Confusion / Q000139:chemically induced; D003922:Diabetes Mellitus, Type 1; D003928:Diabetic Nephropathies / Q000628:therapy; D005260:Female; D006212:Hallucinations / Q000139:chemically induced; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D006435:Renal Dialysis; D014823:Vitreous Hemorrhage / Q000601:surgery*
chemical_list: D000086:Acetazolamide