title: The effect of repeated chemotherapy on the prevalence and intensity of Ascaris lumbricoides and Trichuris trichiura infection.
abstract: The prevalence and intensity of intestinal nematode infections were assessed during 3 anthelminthic interventions in an urban community in Malaysia. The prevalence levels of Ascaris lumbricoides at Interventions 1, 2 and 3 were 30.6%, 18.9% and 15.5%, respectively and the mean intensities were 1.9, 0.75 and 0.81 worms per person. For Trichuris trichiura, the prevalence levels at Interventions 1, 2 and 3 were 46.9%, 21.6% and 15.7%, respectively. The mean intensities for T. trichiura at Interventions 1, 2 and 3 were 3.30, 0.92 and 0.07 worms per person. No gender-related prevalence and intensity were observed for the two geohelminths in this community. Prevalences and intensity had convex age profiles. Although repeated chemotherapeutic intervention reduced both prevalence and intensity levels, intensity was a more sensitive indicator than prevalence. The results indicate that age-targetting treatment at school children of 7-12 years of age would be an appropriate strategy for this community.
authors.affiliation: Department of Biology, Imperial College, London, UK.
authors.forename: L
authors.initials: L
authors.lastname: Chan
authors.forename: S P
authors.initials: SP
authors.lastname: Kan
authors.forename: D A
authors.initials: DA
authors.lastname: Bundy
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D015766:Albendazole / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D001196:Ascariasis / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology; D017164:Ascaris lumbricoides / Q000302:isolation & purification; D002648:Child; D005260:Female; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology; D008296:Malaysia / Q000453:epidemiology; D008297:Male; D009349:Nematode Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology; D015995:Prevalence; D012720:Severity of Illness Index; D012737:Sex Factors; D014257:Trichuriasis / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology; D014258:Trichuris / Q000302:isolation & purification; D014505:Urban Population
chemical_list: D015766:Albendazole