title: Anticoccidial efficacy and chicken toleration of potent new polyether ionophores. 1. The septamycin relative CP-82,009.
abstract: The anticoccidial activity of the ionophore CP-82,009 against laboratory isolates of four major species of poultry Eimeria was investigated. Parameters of anticoccidial efficacy that were evaluated were control of lesions and weight suppression. At 4 and 5 ppm, CP-82,009 demonstrated broad-spectrum anticoccidial efficacy in battery trials that was equivalent to reference commercial ionophores. When CP-82,009 was fed to uninfected broiler chickens at efficacious dose levels, growth rate and feed efficiency were found to be equivalent to commercial agents over a 21-day period in batteries and over a 49-day period in floor pens. From the present studies, it appears that CP-82,009 is an efficacious anticoccidial that is well tolerated by chickens, and that it ranks among the most potent anticoccidial ionophores described to date.
authors.affiliation: Central Research Division, Pfizer Inc, Groton, Connecticut 06340.
authors.forename: A P
authors.initials: AP
authors.lastname: Ricketts
authors.forename: J P
authors.initials: JP
authors.lastname: Dirlam
authors.forename: J E
authors.initials: JE
authors.lastname: Shively
mesh_terms: D000818:Animals; D002645:Chickens; D003048:Coccidiosis / Q000188:drug therapy / Q000662:veterinary*; D003049:Coccidiostats / Q000494:pharmacology / Q000627:therapeutic use*; D004539:Eimeria / Q000187:drug effects*; D004987:Ethers / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D011201:Poultry Diseases / Q000188:drug therapy*; D011714:Pyrans / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D015430:Weight Gain / Q000187:drug effects
chemical_list: D003049:Coccidiostats; D004987:Ethers; D011714:Pyrans; C074361:CP 82009