[The metabolism of eicosanoids, glucocorticoids and cyclic nucleotides in young people with acute pneumonia].
An investigation into the pathogenesis of acute pneumonia in 37 young men made it possible to ascertain the role of arachidonic acid metabolites and hormonal regulation in the pathogenesis of the inflammatory reaction in acute bacterial pneumonia. At the initial stage of inflammation, invasion of the infectious agent leads to phagocytosis activation, stimulates the output of immunoglobulins belonging to different classes, which, binding antigens, form immune complexes influencing the output of biologically active substances. This is accompanied by the destruction of pulmonary tissue, release of lipid peroxidation radicals and proteinases, by the enhancement of arachidonic acid degradation under the destructive action on the membranes of phospholipase A2 cells to form prostaglandins participating in the changes in the tone of bronchi, pulmonary vessels and affecting blood coagulation. Activation of the hypophyseo-adrenal system leads to the attenuation of the effects produced by biologically active substances and exerts varying actions in the acute and convalescence periods. The data obtained stress an important role played by metabolic functions of the lungs in the integrative connections of all the systems of the body maintaining homeostasis in pneumonia and the main function of the lungs, namely ventilation.
Iakovlev
V A
VA
Udal'tsov
B B
BB
Chumak
G E
GE
Karlov
V A
VA
Krasnokutskaia
G N
GN
Boll
S V
SV
Kurganova
T A
TA
D000208:Acute Disease; D000328:Adult; D000917:Antibody Formation; D003289:Convalescence; D015777:Eicosanoids / Q000097:blood*; D005938:Glucocorticoids / Q000097:blood*; D006706:Homeostasis; D006801:Humans; D007111:Immunity, Cellular; D009712:Nucleotides, Cyclic / Q000097:blood*; D011018:Pneumonia, Pneumococcal / Q000097:blood* / Q000276:immunology
D015777:Eicosanoids; D005938:Glucocorticoids; D009712:Nucleotides, Cyclic
Metabolizm éĭkozanoidov, gliukokortikoidov i tsiklicheskikh nukleotidov u molodykh liudeĭ s ostroĭ pnevmonieĭ.