Gonioscopic ab interno laser sclerostomy. A pilot study in glaucoma patients.
OBJECTIVE
The purpose of this study is to evaluate the safety and efficacy of gonioscopic ab interno laser sclerostomy (GLS) in patients with glaucoma.


METHODS
The technique of GLS involves iontophoresis of methylene blue dye (1%) at the limbus to focally dye the sclera and to provide subsequent delivery of 10-microsecond pulsed laser energy to the dyed area through a goniolens. The laser emits at 660 nm, a wavelength that is maximally absorbed by the methylene blue dye. Patients were evaluated for fistula formation, intraocular pressure (IOP) reduction, and adverse sequelae. Thirty-eight treatments were performed in 35 eyes.


RESULTS
Successful complete sclerostomies were achieved in 21 eyes (55%), which was associated with an acute mean reduction in IOP of 23 mmHg. Mean preoperative IOP for all patients was 35 mmHg, and 1 hour after treatment it was reduced to 18.5 mmHg. In 4 of the 38 treatments, there was no acute IOP reduction, and these eyes were judged as failures. The mean follow-up time was 8.2 months with a maximum follow-up of 15 months. By 9 months, 50% of patients had an IOP of 22 mmHg or lower. The number of antiglaucoma medications decreased from 3.1 to 1.7 for all eyes over the 15-month follow-up period. Hyphemas (13%) were the only major complication, and these resolved spontaneously. In only one case did the IOP increase after the procedure.


CONCLUSIONS
The results of this trial indicate that GLS is technically feasible, and preliminary results of IOP control are promising.
Latina
M A
MA
Wellman Laboratories, Massachusetts General Hospital, Boston 02114.
Melamed
S
S
March
W F
WF
Kass
M A
MA
Kolker
A E
AE
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000209:etiology / Q000601:surgery*; D005902:Glaucoma, Open-Angle / Q000209:etiology / Q000601:surgery*; D006068:Gonioscopy; D006801:Humans; D007478:Iontophoresis; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D012599:Sclerostomy