title: [A case of adenocarcinoma of lung cancer with multiple brain metastasis and lymphangitis carcinomatosa responding well to chemotherapy with carboplatin, etoposide and ifosfamide].
abstract: A 75-year-old male who suffered from adenocarcinoma of lung cancer with multiple brain metastases, developed left hemiplegia. After diagnosis, he was treated with 4,000 cGy whole brain radiation, but soon after advanced lymphangitis carcinomatosa set in and his general condition deteriorated. He was administered carboplatin combination with etoposide and ifosfamide. Lymphangitis carcinomatosa disappeared, and the main tumor of lung and brain metastases were not growing. We recommended carboplatin for an old patient or one in poor condition, because it had less cytotoxicity and retained the same antitumor activity compared with cisplatin.
authors.affiliation: Dept. of Neurology, Kansai Rosai Hospital, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hojo
authors.forename: Y
authors.initials: Y
authors.lastname: Kumasaka
authors.forename: S
authors.initials: S
authors.lastname: Nishiyama
authors.forename: T
authors.initials: T
authors.lastname: Higashihara
authors.forename: Y
authors.initials: Y
authors.lastname: Oku
authors.forename: M
authors.initials: M
authors.lastname: Okada
authors.forename: K
authors.initials: K
authors.lastname: Kajiyama
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary; D016190:Carboplatin / Q000008:administration & dosage; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008175:Lung Neoplasms / Q000150:complications / Q000473:pathology*; D008205:Lymphangitis / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D011879:Radiotherapy Dosage
chemical_list: D005047:Etoposide; D016190:Carboplatin; D007069:Ifosfamide