title: Selective avoidance of lymphatic radiotherapy in the conservative management of early breast cancer.
abstract: In view of the morbidity and potential mortality associated with routine post-operative lymph node radiotherapy in women with early stage breast cancer, an attempt has been made to select patients in whom radiotherapy can be withheld. Three hundred and forty-seven consecutive patients treated wide local excision plus or minus axillary surgery have been evaluated. Only 20% were subsequently given radiotherapy to regional nodes. Relapse in the axilla, the supraclavicular fossa or at both these sites have occurred in 16 patients so far, 12 of whom were successfully treated. Systemic relapse was seen in eight of these patients occurring with one exception before or within 3 months of node relapse. Only four have persisting symptoms as a result of nodal relapse. So far, a policy involving selective lymphatic radiotherapy in women treated for early breast cancer appears justified.
authors.affiliation: Department of Radiotherapy and Oncology, Royal Marsden Hospital, Sutton, Surrey, UK.
authors.forename: P J
authors.initials: PJ
authors.lastname: Hoskin
authors.forename: B
authors.initials: B
authors.lastname: Rajan
authors.forename: S
authors.initials: S
authors.lastname: Ebbs
authors.forename: D
authors.initials: D
authors.lastname: Tait
authors.forename: S
authors.initials: S
authors.lastname: Milan
authors.forename: J R
authors.initials: JR
authors.lastname: Yarnold
mesh_terms: D001365:Axilla; D001943:Breast Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D002985:Clinical Protocols; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology; D015182:Lymphatic Irradiation; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009017:Morbidity; D011882:Radiotherapy, High-Energy; D012307:Risk Factors; D015996:Survival Rate; D013997:Time Factors