Effect of dizocilpine maleate on cerebral anoxia and ischemic damage in rodents.
The Protective effects of dizocilpine maleate (DM) against anoxia in mice and ischemic damage in rats of 4-vessel occlusion (4-VO) were studied. DM 0.5 or 1.0 mg.kg-1 ip significantly prolonged the survival time of mice in closed containers. DM 0.5 and 1.0 mg.kg-1 ip 30 min prior to 4-VO obviously accelerated the electroencephalographic recovery, reduced the neuronal loss in the hippocampus, and increased the survival rate after 72-h reperfusion. These effects followed a dose-dependent manner. Our results indicate that selective non-competitive N-methyl-D-aspartate receptor blocker DM protects against anoxic and ischemic cerebral damage.
Ping
H X
HX
Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing.
Su
J
J
Liu
H
H
Liu
G Q
GQ
Xie
L
L
Wu
H Q
HQ
D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy*; D016291:Dizocilpine Maleate / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects; D006624:Hippocampus / Q000473:pathology; D000860:Hypoxia / Q000188:drug therapy*; D008297:Male; D051379:Mice; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000517:prevention & control
D016291:Dizocilpine Maleate