Retinoids and carotenoids as inhibitors of carcinogenesis and inducers of cell-cell communication.
In cell cultures of carcinogen-initiated fibroblasts, a number of retinoids and carotenoids can reversibly inhibit progression to the transformed state. The anticarcinogenic action of retinoids and carotenoids is closely correlated with enhanced gap-junction cell-to-cell communication and with increased synthesis of the gap-junction protein, connexin.
Wolf
G
G
Department of Nutritional Sciences, University of California, Berkeley 94720.
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002338:Carotenoids / Q000494:pharmacology*; D002450:Cell Communication / Q000187:drug effects*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D006801:Humans; D012176:Retinoids / Q000494:pharmacology*
D016588:Anticarcinogenic Agents; D012176:Retinoids; D002338:Carotenoids