title: [The antigenic activity of vaccines made from opportunistic microorganisms in an experiment to immunize animals by oral and combined methods].
abstract: The results of the study of the antigenic activity of multicomponent vaccine consisting of staphylococcal, Klebsiella, Proteus, Escherichia coli antigens and staphylococcal monovaccine, introduced into rabbits and guinea pigs by different routes, are presented. As shown in this study, the multicomponent vaccine introduced orally in 5 administrations stimulated the production of antibodies to all components, but the intensity of antibody formation to each of them was different. Antibodies to E. coli antigen were found to be at the lowest level. Staphylococcal antigen, introduced orally both as the component of the multicomponent vaccine and as the monovaccine, ensured pronounced stimulation of the production of antistaphylococcal antibodies, not lower than that observed after subcutaneous injection. The comparative study of the activity of the multicomponent vaccine introduced by combined routes, oral-subcutaneous and subcutaneous-oral, showed the advantage of the former one.
authors.forename: V N
authors.initials: VN
authors.lastname: Efremova
authors.forename: V M
authors.initials: VM
authors.lastname: Poliachenko
authors.forename: K G
authors.initials: KG
authors.lastname: Kaverina
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000008:administration & dosage* / Q000276:immunology; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000276:immunology; D004338:Drug Combinations; D004926:Escherichia coli / Q000276:immunology; D006168:Guinea Pigs; D007114:Immunization / Q000379:methods*; D007279:Injections, Subcutaneous; D007711:Klebsiella pneumoniae / Q000276:immunology; D011514:Proteus vulgaris / Q000276:immunology; D011817:Rabbits; D013209:Staphylococcal Vaccines / Q000008:administration & dosage / Q000276:immunology; D013211:Staphylococcus aureus / Q000276:immunology; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D004338:Drug Combinations; D013209:Staphylococcal Vaccines
vernacular_title: Izuchenie antigennoĭ aktivnosti vaktsin iz uslovno-patogennykh mikroorganizmov v éksperimente immunizatsii zhivotnykh oral'nymi i kombinirovannymi metodami.