title: Efficacy of the morantel sustained release trilaminate bolus against gastrointestinal nematodes and its influence on immunity in calves.
abstract: An experiment was conducted in calves to investigate the efficacy of a morantel sustained release trilaminate bolus (MSRT) to control gastrointestinal parasitism and to assess the development of immunity during the use of MSRT. Two groups (M and U) of four calves each were infected three times a week with a mixed Ostertagia ostertagi and Cooperia oncophora infection for 12 weeks. Calves of Group M received an MSRT at the start of the experiment. Twenty weeks after the start of the experiment, all animals, including a previously uninfected control group (C), received a challenge with 100,000 Ostertagia and 100,000 Cooperia. After a further 4 weeks all calves were necropsied for worm counts. During the trial calves were weighed and faecal egg counts, larval differentiation and pepsinogen concentrations were determined. The results demonstrated the high level of efficacy of the MSRT in reducing the faecal egg output and preventing parasitic gastroenteritis under conditions of a continuous high rate of infection. Efficacy of treatment was higher for Cooperia than for Ostertagia. Post-mortem worm counts suggested a partially impaired immunity build-up in Group M, at least for Cooperia.
authors.affiliation: Faculty of Veterinary Medicine, Department of Parasitology, Gent, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Vercruysse
authors.forename: P
authors.initials: P
authors.lastname: Dorny
authors.forename: H
authors.initials: H
authors.lastname: Hilderson
authors.forename: P
authors.initials: P
authors.lastname: Berghen
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000276:immunology; D003692:Delayed-Action Preparations; D005243:Feces / Q000469:parasitology; D007110:Immunity, Active / Q000187:drug effects; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000276:immunology / Q000662:veterinary*; D009015:Morantel / Q000008:administration & dosage / Q000627:therapeutic use*; D009349:Nematode Infections / Q000188:drug therapy / Q000276:immunology / Q000662:veterinary*; D010029:Ostertagiasis / Q000188:drug therapy / Q000276:immunology / Q000662:veterinary; D010270:Parasite Egg Count / Q000662:veterinary; D010435:Pepsinogens / Q000097:blood; D011897:Random Allocation; D014252:Trichostrongyloidiasis / Q000188:drug therapy / Q000276:immunology; D015430:Weight Gain
chemical_list: D003692:Delayed-Action Preparations; D010435:Pepsinogens; D009015:Morantel