[Adaptation to chemical mutagens].
Pre-adaptation of normal and tumor cells to the action of methylnitrosourea was studied. To attain these ends, a single low dose (10 mg/kg) was administered to animals two hours prior to the administration of main therapeutic dose (100 mg/kg) and the number of chromosomal rearrangements was determined. A significant decrease in translocation incidence was observed in metaphases of Ehrlich-ICP ascitic strain. Similar results were obtained on cells of murine bone marrow. The mechanisms of pre-adaptation to the action is discussed.
Serebriakova
I V
IV
Fomina
M M
MM
Poroshenko
G G
GG
D000008:Abdominal Neoplasms / Q000648:ultrastructure; D000222:Adaptation, Physiological / Q000187:drug effects*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000648:ultrastructure; D002286:Carcinoma, Ehrlich Tumor / Q000648:ultrastructure; D002478:Cells, Cultured / Q000187:drug effects / Q000648:ultrastructure; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D008770:Methylnitrosourea / Q000008:administration & dosage / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D015162:Micronucleus Tests; D009153:Mutagens / Q000494:pharmacology*; D009368:Neoplasm Transplantation; D013997:Time Factors; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000648:ultrastructure
D009153:Mutagens; D008770:Methylnitrosourea
K voprosu ob adaptatsii k khimicheskim mutagenam.