Separation of the enantiomers of some potassium channel activators using an alpha 1-acid glycoprotein column.
The separations of the enantiomers of some 3,4-dihydro-2,2'-dimethyl-2H-1-benzopyrans and a related tetrahydronaphthalene on alpha 1-acid glycoprotein (Chiral-AGP) are presented, together with the results from an investigation of the effects of organic modifier and pH on the separations achieved. The general utility of Chiral-AGP in separating the enantiomers of compounds from this class of antihypertensive agents is demonstrated in this paper.
Evans
J M
JM
SmithKline Beecham Pharmaceuticals, Pinnacles, Harlow, Essex, UK.
Smith
R J
RJ
Stemp
G
G
D000959:Antihypertensive Agents / Q000032:analysis* / Q000494:pharmacology*; D001578:Benzopyrans / Q000032:analysis* / Q000494:pharmacology*; D002021:Buffers; D002851:Chromatography, High Pressure Liquid; D006863:Hydrogen-Ion Concentration; D007211:Indoles / Q000032:analysis* / Q000494:pharmacology*; D009961:Orosomucoid / Q000032:analysis*; D015221:Potassium Channels / Q000187:drug effects*; D012997:Solvents; D013237:Stereoisomerism
D000959:Antihypertensive Agents; D001578:Benzopyrans; D002021:Buffers; D007211:Indoles; D009961:Orosomucoid; D015221:Potassium Channels; D012997:Solvents; C067406:WAY 120491