Effect of sulglycotide treatment on cell kinetics alterations induced by aspirin in humans.
The effect on gastric epithelial cell proliferation of small doses of aspirin was evaluated in 9 healthy volunteers, with or without administration of sulglycotide, a sulfated glycopeptide with cytoprotective properties. Cell kinetics study was performed by incubation of gastric biopsies with bromodeoxyuridine (BrdU) and immunohistochemistry. A decrease of BrdU-labeling index and a shortening of the height of gastric columns were observed after treatment with aspirin and placebo. No variations were observed after treatment with aspirin and sulglycotide. A decrease of the epithelial cell renewal could be one of the damaging effects of aspirin on the gastric mucosa. The treatment with sulglycotide seems to be effective to prevent this alteration.
Biasco
G
G
Istituto di Clinica Medica e Gastroenterologia, University of Bologna, Italy.
Paganelli
G M
GM
Psilogenis
M
M
Nazzari
M
M
Di Febo
G
G
Siringo
S
S
D000328:Adult; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology*; D001973:Bromodeoxyuridine / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D004311:Double-Blind Method; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D005260:Female; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D008297:Male; D012795:Sialoglycoproteins / Q000494:pharmacology*
D000897:Anti-Ulcer Agents; D012795:Sialoglycoproteins; C009354:sulglicotide; D001973:Bromodeoxyuridine; D001241:Aspirin