Randomized, double-blind study of cefotetan and cefoxitin in post-cesarean section endometritis.
OBJECTIVE
The hypothesis of the study is that cefotetan and cefoxitin will be equally efficacious and safe in the treatment of post-cesarean section endometritis.


METHODS
In a double-blind, randomized manner 140 patients with post-cesarean section endometritis were treated with cefotetan, 2 gm intravenously every 12 hours, or cefoxitin, 2 gm intravenously every 6 hours. They were followed prospectively for clinical response and side effects. Cure rates between the two groups were compared with the chi 2 test.


RESULTS
The cure rates were 83% for cefotetan and 79% for cefoxitin (p = 0.56). No patient required a change in therapy due to adverse effects, and no abnormal bleeding occurred.


CONCLUSIONS
In this study cefotetan and cefoxitin appeared equally effective in treating endometritis with no difference in side effects or complications.
MacGregor
R R
RR
Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104.
Graziani
A L
AL
Samuels
P
P
D000328:Adult; D001419:Bacteria / Q000302:isolation & purification; D015313:Cefotetan / Q000009:adverse effects / Q000627:therapeutic use*; D002440:Cefoxitin / Q000009:adverse effects / Q000627:therapeutic use*; D002585:Cesarean Section / Q000009:adverse effects*; D004311:Double-Blind Method; D004716:Endometritis / Q000188:drug therapy* / Q000209:etiology* / Q000382:microbiology; D005260:Female; D006801:Humans; D011247:Pregnancy; D011446:Prospective Studies; D012008:Recurrence
D015313:Cefotetan; D002440:Cefoxitin