[The effect of clofelin on the carotid sinus and cardiopulmonary baroreceptor reflexes in man].
A study was made of the influence of clophilin on the vasomotor component of the sinocarotid and cardiopulmonary baroreflexes of man. Clophilin was shown to intensify the cardiochronotropic component of the sinocarotid reflex, thereby suppressing blood pressure fall, evoked by activation of carotid sinus mechanoreceptors, and producing no effect on vasoconstriction induced by a decrease of pressure in the right atrium. It is concluded that the mechanism of the hypotensive effect of clophilin is not related to modulation of the baroreceptor reflexes from the regions of high and low pressures.
Zverev
O G
OG
Tsyrlin
V A
VA
D001273:Atmosphere Exposure Chambers; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002346:Carotid Sinus / Q000187:drug effects* / Q000503:physiopathology; D003000:Clonidine / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D008150:Lower Body Negative Pressure; D008168:Lung / Q000187:drug effects* / Q000503:physiopathology; D011311:Pressoreceptors / Q000187:drug effects* / Q000502:physiology; D012018:Reflex / Q000187:drug effects* / Q000502:physiology; D014666:Vasomotor System / Q000187:drug effects / Q000503:physiopathology
D003000:Clonidine
Vliianie klofelina na sinokarotidnyĭ i kardiopul'monal'nyĭ baroretseptornyĭ refleksy u cheloveka.