Long-term prevention of allergic diseases by using protein hydrolysate formula in at-risk infants.
This prospective, long-term study assessed the effects of a protein hydrolysate formula on allergy prevention in infants with a family history of allergy. Infants were randomly assigned to receive either the hydrolysate formula (n = 92) or an adapted cow milk formula (n = 85) alone or with breast-feeding for 4 months. The groups did not differ in family allergy history scores or cord blood IgE levels. After 4 months, total IgE levels and allergic reactions did not differ significantly between groups, although the hydrolysate group had a lower prevalence of eczema. At 12 months of age, neither IgE levels nor allergic reactions were significantly different. At 2 years of age, however, 18 allergic reactions had occurred in the hydrolysate group and 31 had occurred in the control group; the differences were significant for eczema (p < 0.001) but not for asthma. At 4 years of age, allergic signs were found in 11 children in the hydrolysate group and in 17 children in the control group; the difference was significant only for eczema (p < 0.01). These results suggest that early feeding of a protein hydrolysate formula to infants at risk for allergies had a long-term preventive effect on the prevalence of eczema but not of asthma.
Mallet
E
E
Service de Gastroentérologie Pédiatrique, Centre Hospitalo-Universitaire, Rouen, France.
Henocq
A
A
D001827:Body Height; D001835:Body Weight; D002364:Caseins / Q000276:immunology / Q000627:therapeutic use*; D003876:Dermatitis, Atopic / Q000097:blood / Q000453:epidemiology / Q000517:prevention & control*; D005500:Follow-Up Studies; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007225:Infant Food; D007231:Infant, Newborn; D016269:Milk Hypersensitivity / Q000097:blood / Q000517:prevention & control*; D011446:Prospective Studies; D011492:Protein Hydrolysates / Q000276:immunology / Q000627:therapeutic use*; D012307:Risk Factors; D013997:Time Factors
D002364:Caseins; D011492:Protein Hydrolysates; C026375:trypticase-soy broth; D007073:Immunoglobulin E