[Effect of the inhalation ++ anesthetic isoflurane on heart electrophysiology].
In two groups, A and B, both composed of 10 mongrel dogs, we studied the cardiac electrophysiologic effects of 1 and 1.5 MAC isoflurane administered by liquid injection in a closed circuit. In group B the study was done under pharmacological autonomic blockade (AB). With electrode catheters for programmed pacing and endocavitary potential recordings, we determined during the anesthesia with 1 and 1.5 MAC isoflurane: RR, spontaneous and paced AH, and HV intervals, corrected sinus recovery time (CSRT), Wenckebach point (WP), functional and effective refractory periods of atria (AFRP, AERP) and AV node (AVNFRP, AVNERP), and ventricular effective refractory period (VERP), these were compared to the ones obtained with a previous thiopental control. In group A, 1 MAC isoflurane increased over control: AERP and AH interval (p < 0.05), AFRP (p < 0.005), RR and AH paced intervals, WP, AVNFRP and VERP (p < 0.001), adding to these CSRT (p < 0.01) in 1.5 CAM. This level did not show differences with 1 MAC. In group B, 1 MAC isoflurane increased over control: AH (p < 0.05), RR, paced AH intervals, WP and AVNFRP (p < 0.001), adding to these AFRP and AERP (p < 0.05) in 1.5 MAC. This level increased with regard to 1 MAC: AFRP, AERP, AH paced interval and AVNERP (p < 0.05), and AVNFRP (p < 0.005). Isoflurane alone or with AB increased parameters of sinusal automaticity, atrial refractoriness, AV nodal conduction and refractoriness, increasing only without AB ventricular refractoriness and CSRT. With AB atrial and AV nodal refractoriness increased in an anesthetic depth dependent way.
Sarrión Auñón
J
J
Servicio de Anestesiología y Reanimación, Hospital Clínico Universitario, Valencia.
Chorro Gascó
F J
FJ
Negueruela Cardo
A
A
Burguera Pérez
M
M
Sanchis Forés
J
J
Chuliá Campos
V
V
Palanca Sanfrancisco
J M
JM
Such Belenguer
L
L
López Merino
V
V
D000769:Anesthesia, Inhalation; D000818:Animals; D001784:Blood Gas Analysis; D004285:Dogs; D004562:Electrocardiography / Q000187:drug effects*; D004594:Electrophysiology; D005260:Female; D006321:Heart / Q000502:physiology*; D007530:Isoflurane / Q000494:pharmacology*; D008297:Male
D007530:Isoflurane
Efecto del anestésico inhalatorio isoflurano sobre la electrofisiología cardíaca.