Circulating inhibitor of interleukin 1 activity in patients with chronic renal diseases.
The effects of sera derived from patients suffering from chronic renal diseases (endemic Balkan nephropathy, glomerulonephritis and pyelonephritis) on T cell proliferative response was studied. It was found that these sera contained factors which affect interleukin 1 (IL-1) dependent events in T cell proliferative response. The factors prevent costimulatory effects of IL-1 on T cells but do not bind to IL-1, nor do they affect interleukin 2 (IL-2) dependent T cell proliferation. These findings indicate that immuno-suppression observed in some kidney disorders may be partially due to serum immunoinhibitory factors affecting IL-1 activity.
Ramić
Z
Z
Institute of Microbiology and Immunology, School of Medicine, University of Belgrade, Yugoslavia.
Dimković
N
N
Djukanović
L
L
Lazić
M
M
Stepanović
S
S
Simić
M
M
Lukić
M L
ML
D000328:Adult; D000368:Aged; D001449:Balkan Nephropathy / Q000097:blood / Q000276:immunology; D002908:Chronic Disease; D005260:Female; D005921:Glomerulonephritis / Q000097:blood / Q000276:immunology; D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000037:antagonists & inhibitors*; D007376:Interleukin-2 / Q000096:biosynthesis; D007674:Kidney Diseases / Q000097:blood / Q000276:immunology*; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011704:Pyelonephritis / Q000097:blood / Q000276:immunology; D015375:Receptors, Interleukin-2 / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology
D007375:Interleukin-1; D007376:Interleukin-2; D008222:Lymphokines; D015375:Receptors, Interleukin-2