Anergy and suppression in B-cell responses.
Two main ideas have been put forward to explain the unexpectedly low anti-hapten antibody titres which can result from pre-priming a mouse with carrier before hapten-carrier immunization. The first involves the interaction of a network of idiotype-specific suppressor T cells, the second instead arguing for the role of intrinsic B-cell anergy. This paper proposes that the data available can equally be interpreted as reflecting the suboptimal interaction between T and B cells at differing stages of maturity, provided that memory B cells can be divided into two subsets. Further, it is suggested that these considerations must be taken into account in the analysis of B-cell anergy in receptor transgenic mice.
Elliott
J I
JI
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D006241:Haptens / Q000276:immunology; D007108:Immune Tolerance / Q000502:physiology*; D007165:Immunosuppression Therapy; D016219:Immunotherapy, Adoptive; D008211:Lymphocyte Cooperation; D051379:Mice; D008954:Models, Biological; D013601:T-Lymphocytes / Q000276:immunology
D006241:Haptens