[The effect of korinfar and anaprilin on lipid peroxidation and the antioxidant system in hypertension patients].
Changes of lipid peroxidation products and activity of the antioxidant system during corinfar and anaprilin treatment were studied in 36 patients with hypertensive disease (stage II). A decrease of the content of malondialdehyde and dien conjugates was revealed in the blood of these patients after a course of treatment with these agents. Simultaneously, the antioxidant protection of the blood increased: the concentration of reduced glutathione increased, the activity of glutathione peroxidase rose. The changes of oxidated glutathione were not clear. It is suggested that such character of the effect of corinfar and anaprilin on the processes of lipid peroxidation is the result of a direct effect on lipid peroxidation products and also compensatory activation of enzymatic reactions of restoration of natural cellular antioxidants as well as enzymatic system directly utilizing lipoperoxides.
Iarema
N I
NI
D000328:Adult; D000975:Antioxidants; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*; D011433:Propranolol / Q000627:therapeutic use*
D000975:Antioxidants; D008054:Lipid Peroxides; D008315:Malondialdehyde; D011433:Propranolol; D009543:Nifedipine
Vliianie korinfara i anaprilina na sostoianie perekisnogo okisleniia lipidov i antioksidantnoĭ sistemy u bol'nykh gipertonicheskoĭ bolezn'iu.