[The efficacy of hepatoprotectors and cytochrome P-450 inducers in correcting the functional activity of the hepatocyte microsomal system in an acute lesion of the liver in prepuberty].
Intragastric CCl4 inhibited the activity of and lowered the levels of the major components of the hepatic monoohygenase enzyme system in one-month rats. Benzonal was found to be more effective in correcting the impaired monooxygenase enzyme system of hepatic cells in immature rats with acute hepatitis than silibor, phytin and zyxorin.
Khakimov
Z Z
ZZ
Rakhmanov
A Kh
AKh
D000208:Acute Disease; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000150:complications / Q000188:drug therapy / Q000201:enzymology; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000201:enzymology / Q000209:etiology; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis* / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D008099:Liver / Q000187:drug effects*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D010105:Oxygenases / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D012741:Sexual Maturation / Q000187:drug effects*; D013997:Time Factors
D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases
Izuchenie éffektivnosti gepatoprotektorov i induktorov tsitokhroma P-450 v korrektsii funktsional'noĭ aktivnosti mikrosomal'noĭ sistemy gepatotsitov pri ostrom porazhenii pecheni v prepubertatnom periode.