Effects of epidermal growth factor and basic fibroblast growth factor on generation of long-term potentiation in the dentate gyrus of fimbria-fornix-lesioned rats.
The effects of epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) on long-term potentiation (LTP) in the dentate gyrus in vivo were investigated in fimbria-fornix (FF)-lesioned rats. Transection of FF resulted in decreased frequency of LTP generation. Intracerebroventricular injection of EGF (50 ng) and bFGF (50 ng) significantly facilitated LTP generation in the FF-lesioned rats. These results suggest that EGF and bFGF can promote the hippocampal LTP impaired by loss of subcortical afferents.
Abe
K
K
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Ishiyama
J
J
Saito
H
H
D000704:Analysis of Variance; D000818:Animals; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D004558:Electric Stimulation; D004815:Epidermal Growth Factor / Q000008:administration & dosage / Q000494:pharmacology*; D005071:Evoked Potentials / Q000187:drug effects; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D016222:Fibroblast Growth Factor 2; D004815:Epidermal Growth Factor