title: Anticoccidial efficacy and chicken toleration of potent new polyether ionophores. 2. The portmicin relative CP-84,657.
abstract: The current study investigated the anticoccidial activity of the ionophore CP-84,657 against laboratory strains of the five major pathogenic species of Eimeria that infect poultry. Based on lesion scores and weight gain, the ionophore CP-84,657 achieved broad-spectrum anticoccidial efficacy in battery trials at doses of 4 and 5 ppm that was equivalent to reference commercial ionophores. In uninfected chickens, 4 ppm of CP-84,657 was the highest dose that gave growth rate and feed efficiency equivalent to commercial agents over 21 days in batteries and 49 days in floor pens. Ionophore CP-84,657 is an efficacious, well-tolerated anticoccidial in chickens, with potency comparable to that of the most potent known ionophores.
authors.affiliation: Central Research Division, Pfizer Inc, Groton, Connecticut 06340.
authors.forename: A P
authors.initials: AP
authors.lastname: Ricketts
authors.forename: J P
authors.initials: JP
authors.lastname: Dirlam
authors.forename: J E
authors.initials: JE
authors.lastname: Shively
mesh_terms: D000818:Animals; D002645:Chickens; D003048:Coccidiosis / Q000188:drug therapy / Q000662:veterinary*; D003049:Coccidiostats / Q000494:pharmacology / Q000627:therapeutic use*; D004539:Eimeria / Q000187:drug effects*; D005663:Furans / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D011201:Poultry Diseases / Q000188:drug therapy*; D015430:Weight Gain / Q000187:drug effects
chemical_list: D003049:Coccidiostats; D005663:Furans; C065219:CP 84657