[The experimental treatment of cyanide poisoning with a methemoglobin solution].
The stroma-free methemoglobin solution proved to be an effective antidote against acute cyanide poisoning in experiment. The poisoning was induced by intraperitoneal administration to rats of cyanide solutions in doses of 5, 10 and 15 mg/kg. Methemoglobin solutions were injected intravenously in doses of 2 and 4 g/kg. All the rats given methemoglobin solution after the administration of cyanide survived. Spectrophotometry of rat urine demonstrated rapid excretion of methemoglobin cyanide.
Kontuganov
N N
NN
Smirnov
I V
IV
D000818:Animals; D000931:Antidotes / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D003486:Cyanides / Q000506:poisoning*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008706:Methemoglobin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000378:metabolism / Q000627:therapeutic use* / Q000652:urine; D011041:Poisoning / Q000188:drug therapy / Q000401:mortality / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D012996:Solutions
D000931:Antidotes; D003486:Cyanides; D012996:Solutions; C007169:cyanomethemoglobin; D008706:Methemoglobin
Lechenie otravleniia tsianidami rastvorom metgemoglobina v éksperimente.