Circulatory basophilia in guinea pigs with delayed-type hypersensitivity. Topical antigenic provocation induces circulatory basophilia.
Circulatory basophilia could be induced in inbred guinea pigs systematically immunized with ovalbumin and consequently provoked repeatedly with dissolved ovalbumin applied onto the mucosa of the nares or the outer eye. The degree of the increase in circulatory basophil granulocytes depended on the adjuvant used and was significantly more pronounced after immunization with Freund's complete adjuvant than with alhydrogel (Al(OH)3). The degree of basophilia was also dependent on the animal strain, but different in two strains selected for high-asthma trait.
Sompolinsky
D
D
Institute of Medical Microbiology, University of Copenhagen, Denmark.
Katzenstein
T
T
Lundberg
L
L
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000287:Administration, Topical; D000818:Animals; D001491:Basophils / Q000276:immunology*; D002452:Cell Count; D005260:Female; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000097:blood*; D007111:Immunity, Cellular; D008297:Male
D000276:Adjuvants, Immunologic