title: Penetration of cefpodoxime proxetil in lung parenchyma and epithelial lining fluid of noninfected patients.
abstract: The pulmonary disposition of cefpodoxime was studied in 12 patients with pulmonary opacities after a single oral dose of 260 mg of cefpodoxime-proxetil, which is equivalent to 200 mg of cefpodoxime. Blood and lung tissue samples were collected during surgery, and bronchoalveolar lavage was carried out 3 h (group A) or 6 h (group B) after drug administration. Urea was used as an endogenous marker for measurement of the volume of epithelial lining fluid (ELF). Concentrations were measured by using a microbiological assay. The mean concentrations of cefpodoxime in plasma, ELF, and lung tissue were, respectively, 1.85 +/- 0.82 mg/liter, 0.22 +/- 0.13 mg/liter, and 0.89 +/- 0.80 mg/kg of body weight in group A and 1.40 +/- 1.25 mg/liter, 0.12 +/- 0.14 mg/liter, and 0.84 +/- 0.61 mg/kg in group B. Concentrations in lung parenchyma 6 h after dosing were at least equal to or above the MICs for 90% of the strains of most organisms commonly found in respiratory tract infections, whereas data for ELF suggest levels of drug insufficient to inhibit bacteria.
authors.affiliation: Department of Microbiology, Bichat-Claude Bernard University Hospital, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Muller-Serieys
authors.forename: C
authors.initials: C
authors.lastname: Bancal
authors.forename: M C
authors.initials: MC
authors.lastname: Dombret
authors.forename: P
authors.initials: P
authors.lastname: Soler
authors.forename: G
authors.initials: G
authors.lastname: Murciano
authors.forename: M
authors.initials: M
authors.lastname: Aubier
authors.forename: E
authors.initials: E
authors.lastname: Bergogne-Berezin
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D015296:Ceftizoxime / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D004848:Epithelium / Q000378:metabolism; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011355:Prodrugs / Q000493:pharmacokinetics*; D011897:Random Allocation; D000097627:Cefpodoxime Proxetil
chemical_list: D015296:Ceftizoxime; D011355:Prodrugs; D000097627:Cefpodoxime Proxetil