title: Oral magnesium supplementation improves metabolic variables and muscle strength in alcoholics.
abstract: Magnesium deficiency is common among chronic alcoholics, but the knowledge of oral magnesium supplementation to this group is limited. We, therefore, randomized 49 chronic alcoholics, moderate to heavy drinkers for at least 10 years to receive oral magnesium or placebo treatment for 6 weeks according to a double-blind protocol. Effects on metabolic variables and muscle strength were analyzed. Significant reduction of aspartate-aminotransferase (ASAT), alanine-aminotransferase (ALAT) and gamma-glutamyl-transpeptidase (GGT) were seen after magnesium, whereas no change was observed with placebo. Bilirubin decreased in both groups. Serum Na, Ca, and P increased significantly during magnesium therapy compared with no statistically significant change in the placebo group. Serum K and Mg increased slightly after magnesium supplementation and decreased in the placebo group, resulting in a significant difference between the two groups at the end of the study. Muscle strength increased significantly during magnesium treatment, contrasting to no change with placebo. Blood pressure, heart rate, hematological variables, serum lipids (cholesterol, HDL, TG), glucose tolerance, and creatinine were unchanged in the two groups after treatment. Alcohol consumption was similar before and during the trial and does not explain the differences between the two groups The results shows that short-term oral magnesium therapy may improve liver cell function, electrolyte status, and muscle strength in chronic alcoholics.
authors.affiliation: Department of Internal Medicine, Baerum Hospital, Sandvika, Norway.
authors.forename: L
authors.initials: L
authors.lastname: Gullestad
authors.forename: L O
authors.initials: LO
authors.lastname: Dolva
authors.forename: E
authors.initials: E
authors.lastname: Søyland
authors.forename: A T
authors.initials: AT
authors.lastname: Manger
authors.forename: D
authors.initials: D
authors.lastname: Falch
authors.forename: J
authors.initials: J
authors.lastname: Kjekshus
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000150:complications / Q000534:rehabilitation*; D004311:Double-Blind Method; D006801:Humans; D007537:Isometric Contraction / Q000187:drug effects*; D008111:Liver Function Tests; D008274:Magnesium / Q000008:administration & dosage*; D008275:Magnesium Deficiency / Q000534:rehabilitation*; D008875:Middle Aged
chemical_list: D008274:Magnesium