Effects of nitric oxide-related compounds and carperitide on hemodynamics and hematocrit in anesthetized rats.
Sodium nitroprusside, nitroglycerin and carperitide (alpha-human ANP) all reduced mean blood pressure, but only carperitide increased the hematocrit in rats with bilateral renal artery- and ureter-ligation. NG-Monomethyl-L-arginine, a selective inhibitor of nitric oxide synthesis, elevated the mean blood pressure but did not change the hematocrit significantly. These findings suggest that ANP has a physiological role in regulating circulatory blood volume distinct from that of NO, although both increase intracellular cyclic GMP in the vasculature.
Aisaka
K
K
Laboratory of Experimental and Molecular Pharmacology, Suntory Institute for Biomedical Research, Osaka, Japan.
Miyazaki
T
T
Hidaka
T
T
Ohno
T
T
Ishihara
T
T
Kanai
T
T
D000758:Anesthesia; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006400:Hematocrit; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism / Q000494:pharmacology*; D005996:Nitroglycerin / Q000494:pharmacology; D009599:Nitroprusside / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins / Q000494:pharmacology; D019323:omega-N-Methylarginine
D010446:Peptide Fragments; D011994:Recombinant Proteins; D009599:Nitroprusside; D019323:omega-N-Methylarginine; D009569:Nitric Oxide; D009320:Atrial Natriuretic Factor; D001120:Arginine; D005996:Nitroglycerin