Acetazolamide in hemodialysis patients: a rational use after ocular surgery.
Acetazolamide is a weak diuretic used to decrease production of aqueous humor in the eye. Hemodialysis patients undergoing ocular surgery may benefit from acetazolamide; however, no pharmacokinetic data are available for this group of patients. We report a patient who received acetazolamide 250 mg every 6 hours after ophthalmic surgery and developed reversible neurological side effects associated with very high plasma concentrations. Using pharmacokinetic analysis, we suggest an alternate administration of acetazolamide for end-stage renal patients.
Roy
L F
LF
Department of Medicine, Hôpital Saint-Luc, Montréal, Quebec, Canada.
Dufresne
L R
LR
Legault
L
L
Long
H
H
Morin
C
C
D000086:Acetazolamide / Q000009:adverse effects* / Q000097:blood / Q000493:pharmacokinetics; D000328:Adult; D001921:Brain / Q000187:drug effects*; D003221:Confusion / Q000139:chemically induced; D003922:Diabetes Mellitus, Type 1; D003928:Diabetic Nephropathies / Q000628:therapy; D005260:Female; D006212:Hallucinations / Q000139:chemically induced; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D006435:Renal Dialysis; D014823:Vitreous Hemorrhage / Q000601:surgery*
D000086:Acetazolamide