[A comparative evaluation of the cardioprotective and antianginal actions of energy-providing agents].
The limitation of a myocardial necrotic area by some energy-yielding compounds in rat coronary occlusion and their capacity to elevate the ischemia threshold in conscious rabbits were studied. Sodium malate, ascorbic acid and phosphoenolpyruvate were demonstrated to reduce the sizes of necrotic areas and increase the ischemia threshold, whereas cytochrome C and fructose-1,6-diphosphate were effective solely in limiting the infection area. It was concluded that the preventive antianginal effect of energy-yielding and electron-accepting compounds depended on their capacity to accumulate in intact cardiomyocytes.
Sernov
L N
LN
Rozonov
Iu B
IuB
Gatsura
V V
VV
D000818:Animals; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004734:Energy Metabolism / Q000187:drug effects*; D006019:Glycolysis / Q000187:drug effects; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D011817:Rabbits; D051381:Rats
D002317:Cardiovascular Agents
Sravnitel'naia otsenka kardioprotektornogo i antianginal'nogo deĭstviia nekotorykh énergoobespechivaiushchikh sredstv.