[Effects of captopril on microcirculation and tissue oxygen balance in patients with hypertension].
Bulbar conjunctival microcirculation, aggregation of platelets and red blood cells, skin oxygen balance were studied in 22 patients with Stage II hypertensive disease. Captopril was found to decrease not only blood pressure, but aggregation of platelets and red blood cells and to improve tissue oxygen supply. With inadequate doses of the drug, an extreme lowering in blood pressure resulted in deteriorated skin oxygen supply along with unaltered aggregation of cellular elements.
Kozlovskiĭ
V I
VI
Barkun
S P
SP
Koshelapov
V I
VI
Chupakhina
O P
OP
D000328:Adult; D002216:Captopril / Q000494:pharmacology* / Q000627:therapeutic use; D003228:Conjunctiva / Q000098:blood supply; D004903:Erythrocyte Aggregation / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008833:Microcirculation / Q000187:drug effects*; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D012867:Skin / Q000187:drug effects / Q000378:metabolism
D010975:Platelet Aggregation Inhibitors; D002216:Captopril
Vliianie kaptoprila na mikrotsirkuliatsiiu i kislorodnyĭ balans tkaneĭ u bol'nykh gipertonicheskoĭ bolezn'iu.