Expression of adhesion molecules in lymphoproliferative disorders.
We review the role of adhesion molecule expression on malignant lymphoid cells as delineated by experimental studies and clinical observation. Adhesion molecules of the Ig superfamily, integrins, selectins, and the lymphocyte homing receptor CD44 mediate cell-to-cell and cell-to-extracellular matrix interactions. These molecules have been investigated with the aim (i) of defining certain biological features of the malignant cells, (ii) of providing a rationale to understand tumor organization, metastasis and organ specificity, and (iii) of detecting disease subsets and prognostic groups.
Grossi
C E
CE
Dept. of Human Anatomy, University of Genova, Italy.
Zarcone
D
D
Tenca
C
C
De Rossi
G
G
Mandelli
F
F
D000818:Animals; D015815:Cell Adhesion Molecules / Q000032:analysis / Q000502:physiology*; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000378:metabolism / Q000473:pathology*; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology; D011379:Prognosis
D015815:Cell Adhesion Molecules