Melatonin induced increase in gamma-interferon production by murine splenocytes.
Previously, we demonstrated that production of gamma-interferon (gamma-IFN) by the mouse splenocytes isolated at night was higher than from those isolated in the morning. In this paper we show that melatonin increased gamma-IFN production by murine splenocytes. Moreover, this stimulating effect was significantly higher (10 times) in the cells isolated at night than in those isolated in the morning (2 times).
Colombo
L L
LL
Department of Family and Community Medicine, Arizona Health Sciences Center, University of Arizona, Tucson 85724.
Chen
G J
GJ
Lopez
M C
MC
Watson
R R
RR
D000818:Animals; D002478:Cells, Cultured; D002940:Circadian Rhythm; D003208:Concanavalin A; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007371:Interferon-gamma / Q000378:metabolism*; D008550:Melatonin / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D015375:Receptors, Interleukin-2 / Q000378:metabolism; D013154:Spleen / Q000166:cytology / Q000187:drug effects*
D015375:Receptors, Interleukin-2; D003208:Concanavalin A; D007371:Interferon-gamma; D008550:Melatonin