[A case of adult onset hypophosphatemic vitamin D resistant osteomalacia].
A case of adult onset hypophosphatemic vitamin D resistant osteomalacia is described. A 40-year-old female who complained of thorax and lumbar pain and gait disturbance was admitted to our hospital on 7 November, 1988. The patient had hypophosphatemia with normal plasma calcium, parathyroid hormone and 25-hydroxy vitamin D3 concentrations, but had decreased tubular reabsorption of phosphate and decreased plasma 1, 25-dihydroxy vitamin D3 concentrations. The iliac crest bone biopsy showed osteomalacic changes. The 99mTc-MDP bone scintigram showed evidence of increased bone turnover with raised plasma alkaline phosphatase concentrations. After treatment with oral 1 alpha-hydroxy vitamin D3 (3-6 micrograms/day) and intravenous or oral phosphate supplement (0.47-1.74g/day), the subjective and clinical findings improved.
Katagiri
T
T
Second Department of Internal Medicine, Saitama Medical School.
Suzuki
T
T
Akiyama
Y
Y
Ishibashi
T
T
Hara
K
K
Oka
H
H
Imai
T
T
Kobayashi
K
K
Kitagawa
H
H
Ohno
S
S
D000328:Adult; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000627:therapeutic use; D010018:Osteomalacia / Q000097:blood / Q000188:drug therapy*; D010710:Phosphates / Q000097:blood* / Q000627:therapeutic use; D014807:Vitamin D / Q000627:therapeutic use*
D006887:Hydroxycholecalciferols; D010710:Phosphates; D014807:Vitamin D; C008088:alfacalcidol