title: Per rectal diazepam therapy in convulsive disorders.
abstract: One hundred and twenty children with persistent convulsions (lasting > or = 10 min) were treated with per rectal diazepam (dosage: 0.2 to 0.7 mg/kg/dose). Another group of 100 age matched children with convulsions, along with those who did not respond to rectal therapy were given intravenous diazepam in a dosage of 0.2 to 0.3 mg/kg/dose. Rectal treatment was effective in 80.83% cases while intravenous diazepam was effective in 90% cases which is statistically just significant (p < 0.05). No significant difference was observed in the efficacy of two routes of administration in controlling convulsions of different clinical types and various etiological groups (p < 0.05), except for primary generalized type where intravenous route was more effective than the rectal one (p < 0.05). No significant side-effect was observed with rectal therapy. Among the 23 (19.17%) children in whom rectal therapy failed, 12 (10%) responded to intravenous diazepam while the remaining 11 (9.17%) cases were resistant to both routes of administration.
authors.affiliation: Department of Pediatrics, S.N. Medical College, Agra.
authors.forename: A
authors.initials: A
authors.lastname: Kalra
authors.forename: N
authors.initials: N
authors.lastname: Chaturvedi
authors.forename: V M
authors.initials: VM
authors.lastname: Vashishtha
authors.forename: K N
authors.initials: KN
authors.lastname: Dube
authors.forename: K
authors.initials: K
authors.lastname: Kalra
mesh_terms: D000285:Administration, Rectal; D002648:Child; D002675:Child, Preschool; D003975:Diazepam / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007275:Injections, Intravenous; D008297:Male; D012640:Seizures / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D003975:Diazepam