[Synthesis and analgesic action of 6,7-methylenedioxy-1(2H,4H)-acridone derivatives].
Thirteen derivatives of 6,7-methylenedioxy-1 (2H, 4H)-acridone were prepared. The structures of all the compounds synthesized were characterized by elemental analysis, IR and 1H NMR spectra. Compounds IIa, IIb, IId, IIe, IIf increased significantly the pain threshold using the hot-plate method.
Han
G F
GF
Department of Medical Laboratory, Jilin Medical College.
Ouyang
J
J
Wang
J J
JJ
Jiao
S P
SP
Jiang
G J
GJ
D000166:Acridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000700:Analgesics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D005260:Female; D051379:Mice; D010146:Pain / Q000503:physiopathology; D012684:Sensory Thresholds / Q000187:drug effects
D000166:Acridines; D000700:Analgesics