Myelination of the optic radiation in Leber congenital amaurosis.
We have studied the myelination of the visual pathway by magnetic resonance imaging in seven children (aged 5 months to 16 years) with Leber congenital amaurosis. The corpus geniculatum laterale and the retrogeniculate optic radiation had a normal appearance on MRI in all patients. Therefore we conclude that normal myelination of the optic radiation, as it can be grossly assessed by MRI, can take place even with absent or greatly reduced visual sensory input.
Steinlin
M
M
Children's University Hospital, Zurich, Switzerland.
Martin
E
E
Schenker
K
K
Boltshauser
E
E
D000293:Adolescent; D001766:Blindness / Q000151:congenital* / Q000473:pathology / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D004594:Electrophysiology; D004596:Electroretinography; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009186:Myelin Sheath / Q000502:physiology*; D009778:Occipital Lobe / Q000473:pathology; D015418:Optic Atrophies, Hereditary / Q000473:pathology / Q000503:physiopathology*; D009900:Optic Nerve / Q000503:physiopathology; D012165:Retinal Ganglion Cells / Q000502:physiology; D013577:Syndrome