Anti-neoplastic effect of halocynthiaxanthin, a metabolite of fucoxanthin.
We have reported that fucoxanthin, a natural carotenoid, inhibited the growth of human neuroblastoma GOTO cells. In the present study, we show that a metabolite of fucoxanthin, halocynthiaxanthin, which is isolated from sea squirt Halocynthia roretzi, has a more potent inhibitory effect. Halocynthiaxanthin (5 micrograms/ml) caused complete suppression of GOTO cell proliferation, whereas fucoxanthin reduced the growth rate by only 88.8% compared with the control, at day 2 after the drug treatment. Furthermore, halocynthiaxanthin also inhibited the growth of other human malignant tumor cells. Thus halocynthiaxanthin seems to be a promising anti-neoplastic agent.
Nishino
H
H
Department of Biochemistry, Kyoto Prefectural University of Medicine, Japan.
Tsushima
M
M
Matsuno
T
T
Tanaka
Y
Y
Okuzumi
J
J
Murakoshi
M
M
Satomi
Y
Y
Takayasu
J
J
Tokuda
H
H
Nishino
A
A
D000970:Antineoplastic Agents / Q000494:pharmacology*; D002338:Carotenoids / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology; D004273:DNA, Neoplasm / Q000096:biosynthesis / Q000187:drug effects; D005502:Food; D015870:Gene Expression / Q000187:drug effects; D016259:Genes, myc / Q000187:drug effects / Q000235:genetics; D006367:HeLa Cells; D006801:Humans; D007700:Kinetics; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000187:drug effects; D009447:Neuroblastoma / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000473:pathology; D012334:RNA, Neoplasm / Q000096:biosynthesis / Q000187:drug effects; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology; D014407:Tumor Cells, Cultured; D024341:Xanthophylls
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D009363:Neoplasm Proteins; D012334:RNA, Neoplasm; D024341:Xanthophylls; C025164:fucoxanthin; D002338:Carotenoids; C073045:halocynthiaxanthin