Isochromosome 14q and leukemia with dysplastic features.
We report a case of chronic myelomonocytic leukemia (CMMoL) with unusual features and an isochromosome 14q as the sole abnormality. A review of the literature suggests that isochromosome 14q (or trisomy 14) is a marker of leukemia with dysplastic features.
Liu
H W
HW
Department of Pathology, University of Hong Kong, Queen Mary Hospital.
Lie
K W
KW
Chan
L C
LC
D000754:Anemia, Refractory, with Excess of Blasts / Q000150:complications; D002471:Cell Transformation, Neoplastic; D002883:Chromosomes, Human, Pair 14; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications; D015477:Leukemia, Myelomonocytic, Chronic / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012010:Red-Cell Aplasia, Pure / Q000150:complications; D014314:Trisomy