title: Bactericidal activity of ramoplanin against antibiotic-resistant enterococci.
abstract: Ramoplanin, a new lipoglycodepsipeptide antibiotic, was uniformly active against 65 strains of enterococci, including strains highly resistant to vancomycin, penicillin G, and gentamicin. MBCs were usually within a fourfold dilution of the MICs. In time-kill studies, ramoplanin alone demonstrated dose-dependent bactericidal activity against enterococcal strains that resisted killing by vancomycin or penicillin in combination with gentamicin.
authors.affiliation: Medical College of Pennsylvania, Philadelphia 19129.
authors.forename: C C
authors.initials: CC
authors.lastname: Johnson
authors.forename: S
authors.initials: S
authors.lastname: Taylor
authors.forename: P
authors.initials: P
authors.lastname: Pitsakis
authors.forename: P
authors.initials: P
authors.lastname: May
authors.forename: M E
authors.initials: ME
authors.lastname: Levison
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D047630:Depsipeptides; D004352:Drug Resistance, Microbial; D016983:Enterococcus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic
chemical_list: D000900:Anti-Bacterial Agents; D047630:Depsipeptides; D010456:Peptides, Cyclic; C041438:ramoplanin