Theophylline-mexiletine interaction: a case report.
Theophylline and mexiletine can be prescribed in patients with chronic obstructive pulmonary disease with coexistent arrhythmias. The drugs have common metabolic pathways that may result in an interaction. A patient who was taking theophylline became toxic after the initiation of mexiletine. Discontinuation of mexiletine led to an improvement in theophylline clearance.
Kendall
J D
JD
Pharmacy Service, Department of Veterans Affairs Medical Center, Erie, PA 16504.
Chrymko
M M
MM
Cooper
B E
BE
D000368:Aged; D003692:Delayed-Action Preparations; D004347:Drug Interactions; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy; D008297:Male; D008801:Mexiletine / Q000378:metabolism* / Q000627:therapeutic use; D013806:Theophylline / Q000378:metabolism* / Q000627:therapeutic use
D003692:Delayed-Action Preparations; D008801:Mexiletine; D013806:Theophylline