[Effect of ketoconazole on the activity of key enzymes of biosynthesis of cholesterol and its esters in the liver of rats maintained on a cholesterol-enriched diet].
Ketoconazole in vivo has been studied for its effect on the activity of key enzymes of the cholesterol and its esters' biosynthesis in the liver and on the cholesterol concentration in certain fractions of blood lipoproteins in normal and cholesterol-fed rats. It is established that ketoconazole decreases cholesterol concentration in low-density lipoproteins and in very low-density lipoproteins as well as decrease the acyl-CoA-cholesterol acyl-transferase activity and increases the 3-hydroxy-3-methyl-glutaryl-CoA-reductase activity in the liver microsomes of intact and test animals. It is supposed that the possible cause of the observed changes can be a disturbance in regulation of basic links of cholesterol metabolism in the liver.
Dushkin
M I
MI
Ivanova
M V
MV
D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis*; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D004952:Esters; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism*; D007425:Intracellular Membranes / Q000378:metabolism; D007654:Ketoconazole / Q000494:pharmacology*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D002785:Sterol O-Acyltransferase / Q000378:metabolism*
D002791:Cholesterol, Dietary; D004952:Esters; D008074:Lipoproteins; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases; D002785:Sterol O-Acyltransferase; D007654:Ketoconazole
Vliianie ketokonazola na aktivnost' kliuchevykh fermentov biosinteza kholesterina i ego éfirov v pecheni krys, soderzhavshikhsia na obogashchennoĭ kholesterinom diete.