title: Nitrogen dioxide exposure and urinary excretion of hydroxyproline and desmosine.
abstract: The relationship between average and peak personal exposure to nitrogen dioxide and urinary excretion of hydroxyproline and desmosine was investigated in a population of preschool children and their mothers. Weekly average personal nitrogen dioxide exposures for subjects who resided in homes with one or more potential nitrogen dioxide source (e.g., a kerosene space heater, gas stove, or tobacco smoke) ranged between 16.3 and 50.6 ppb (30.6 and 95.1 micrograms/m3) for children and between 16.9 and 44.1 ppb (12.8 and 82.9 micrograms/m3) for mothers. In these individuals, the hydroxyproline-to-creatinine and desmosine-to-creatinine ratios were unrelated to personal nitrogen dioxide exposure--even though continuous monitoring documented home nitrogen dioxide concentration peaks of 100-475 ppb lasting up to 100 h in duration. Significantly higher hydroxyproline-to-creatinine and desmosine-to-creatinine ratios were observed in children, compared with mothers (p < .001 and .003, respectively).
authors.affiliation: University of North Carolina, Chapel Hill.
authors.forename: J L
authors.initials: JL
authors.lastname: Adgate
authors.forename: H F
authors.initials: HF
authors.lastname: Reid
authors.forename: R
authors.initials: R
authors.lastname: Morris
authors.forename: R W
authors.initials: RW
authors.lastname: Helms
authors.forename: R A
authors.initials: RA
authors.lastname: Berg
authors.forename: P C
authors.initials: PC
authors.lastname: Hu
authors.forename: P W
authors.initials: PW
authors.lastname: Cheng
authors.forename: O L
authors.initials: OL
authors.lastname: Wang
authors.forename: P A
authors.initials: PA
authors.lastname: Muelenaer
authors.forename: A M
authors.initials: AM
authors.lastname: Collier
mesh_terms: D000328:Adult; D000393:Air Pollutants; D002648:Child; D002675:Child, Preschool; D003895:Desmosine / Q000652:urine*; D004781:Environmental Exposure; D004784:Environmental Monitoring / Q000379:methods / Q000592:standards; D005260:Female; D006361:Heating; D006801:Humans; D006909:Hydroxyproline / Q000652:urine*; D007223:Infant; D009585:Nitrogen Dioxide / Q000378:metabolism; D012621:Seasons; D012907:Smoking
chemical_list: D000393:Air Pollutants; D003895:Desmosine; D006909:Hydroxyproline; D009585:Nitrogen Dioxide