[D-penicillamine: old drug, new indication? D-penicillamine reduced pulmonary hypertension induced by free radicals].
Pulmonary hypertension is one of the major problems in the neonatal period. Free oxygen radicals play important role in the activation of pulmonary vasoconstriction. Since D-penicillamine has proved to be a strong antioxidant in newborns it was of interest to investigate the effect of the drug in the oxygen radical induced pulmonary hypertension. According to our animal experiments D-penicillamine inhibits the xanthine oxidase induced pulmonary hypertension in piglets. The same inhibitory effect was observed in the prostanoid metabolism. Could D-penicillamine be used in the treatment of pulmonary hypertension in the newborn?
Oroszlán
G
G
Nógrád Megyei Onkormányzat Kórház, Salgótarján, Gyermekosztály.
Sanderud
J
J
Saugstad
O D
OD
Lakatos
L
L
D000818:Animals; D000831:Animals, Newborn; D004353:Drug Evaluation, Preclinical; D005609:Free Radicals / Q000494:pharmacology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000139:chemically induced / Q000188:drug therapy*; D007231:Infant, Newborn; D010100:Oxygen; D010396:Penicillamine / Q000627:therapeutic use*; D013552:Swine
D005609:Free Radicals; D010396:Penicillamine; D010100:Oxygen
D-penicillamin: régi gyógyszer, új indikáció? A D-penicillamin csökkenti a szabad gyök indukálta kísérletes pulmonalis hypertensiót.