title: [A case of postoperative hepatic injury after sevoflurane anesthesia].
abstract: A 63 year old man underwent MCA aneurysmal neck clipping under O2-N2O-enflurane anesthesia. On the 46th postoperative day after the first operation, he had cranioplasty under O2-N2O-sevoflurane anesthesia. Hepatic injury occurred after the operation, and GOT, GPT and bilirubin increased above 700 IU.l-1, 800 IU.l-1 and 15.0 mg.dl-1 respectively but consciousness disturbance, hyperammonemia and DIC did not appear. His hepatic injury improved on conservative therapy. It seems that his hepatic injury was not caused by hepatitis viruses or hepatotoxicity of any drugs, but caused by cross sensitization between halogenated inhalation anesthetics, especially enflurane and sevoflurane, judging from drug induced lymphocyte stimulating test (DLST). We have to select an anesthetic method considering potential hepatic injury by halogenated anesthetics in a case of repeated anesthesia and operations during a short-term.
authors.affiliation: Division of Anesthesiology, Asahikawa Red Cross Hospital.
authors.forename: Y
authors.initials: Y
authors.lastname: Shichinohe
authors.forename: Y
authors.initials: Y
authors.lastname: Masuda
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Kotaki
authors.forename: T
authors.initials: T
authors.lastname: Omote
authors.forename: M
authors.initials: M
authors.lastname: Shichinohe
authors.forename: A
authors.initials: A
authors.lastname: Namiki
mesh_terms: D000769:Anesthesia, Inhalation / Q000009:adverse effects*; D000777:Anesthetics / Q000276:immunology*; D003429:Cross Reactions; D004737:Enflurane / Q000276:immunology*; D004987:Ethers / Q000276:immunology*; D006801:Humans; D008107:Liver Diseases / Q000276:immunology*; D008297:Male; D008738:Methyl Ethers; D008875:Middle Aged; D011183:Postoperative Complications / Q000276:immunology*; D000077149:Sevoflurane
chemical_list: D000777:Anesthetics; D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane; D004737:Enflurane