title: A case of congenital leukemia with monosomy 7.
abstract: A case of congenital leukemia with monosomy 7 is reported. Immunological study of the blast cells using monoclonal antibodies was suggestive of both myelomegakaryocytic and T-lymphoblastic leukemia. Chromosomal analysis of the bone marrow cells showed monosomy 7. Chemotherapy was initiated with a combination of adriamycin, cytosine arabinoside, 6-mercaptopurine, and prednisolone. The patient obtained complete remission, which has been maintained for 4 years and 1 month. He receives no chemotherapy now. Our case shows that monosomy 7 in congenital leukemia is rare, but the presence of monosomy 7 in congenital leukemia does not necessarily indicate a poor prognosis.
authors.affiliation: Department of Pediatrics, Gunma University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shitara
authors.forename: N
authors.initials: N
authors.lastname: Suetake
authors.forename: S
authors.initials: S
authors.lastname: Yugami
authors.forename: M
authors.initials: M
authors.lastname: Sotomatu
authors.forename: Y
authors.initials: Y
authors.lastname: Oshima
authors.forename: H
authors.initials: H
authors.lastname: Ijima
authors.forename: T
authors.initials: T
authors.lastname: Kuroume
authors.forename: S
authors.initials: S
authors.lastname: Nakazawa
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002897:Chromosomes, Human, Pair 7; D003561:Cytarabine / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D007938:Leukemia / Q000151:congenital* / Q000188:drug therapy / Q000235:genetics; D007947:Leukemia, Megakaryoblastic, Acute / Q000235:genetics / Q000473:pathology; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics / Q000473:pathology; D008297:Male; D015122:Mercaptopurine / Q000008:administration & dosage; D009006:Monosomy; D011239:Prednisolone / Q000008:administration & dosage; D012074:Remission Induction
chemical_list: D003561:Cytarabine; D004317:Doxorubicin; D011239:Prednisolone; D015122:Mercaptopurine