title: [Use of the magnitude of vitamin and vitamin metabolite excretion as indicators of availability of vitamins B2, B6, and niacin].
abstract: Alimentary deficiency of riboflavin in rats caused a decrease in excretion of vitamin B2 with urine simultaneously with lowering in daily excretion of 4-pyridoxylic acid (4-PA) and N1-methyl nicotinamide (N1-MNA); these patterns are usually used as indicators of pyridoxine and niacin availability. The similar decrease in excretion of 4-PA and N1-MNA with urine but without alterations in NAD+NADP concentrations in erythrocytes was detected in women deficient in vitamin B2. Content of nicotinamide coenzymes in erythrocytes correlated with excretion of N1-MNA with urine only under normal conditions of riboflavin availability. Use of the criteria involving rates of 4-PA and N1-MNA excretion for evaluation of pyridoxine and niacin deficiency is discussed.
authors.forename: V M
authors.initials: VM
authors.lastname: Kodentsova
authors.forename: O A
authors.initials: OA
authors.lastname: Vrzhesinskaia
authors.forename: V B
authors.initials: VB
authors.lastname: Spirichev
mesh_terms: D000328:Adult; D000818:Animals; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D009525:Niacin / Q000378:metabolism*; D009536:Niacinamide / Q000031:analogs & derivatives / Q000652:urine; D011735:Pyridoxic Acid / Q000652:urine; D011736:Pyridoxine / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012256:Riboflavin / Q000378:metabolism*; D012257:Riboflavin Deficiency / Q000378:metabolism; D014815:Vitamins / Q000378:metabolism / Q000652:urine*
chemical_list: D014815:Vitamins; D009243:NAD; D009536:Niacinamide; D009525:Niacin; D009249:NADP; D011735:Pyridoxic Acid; D011736:Pyridoxine; D012256:Riboflavin; C008472:N-methylnicotinamide
vernacular_title: Ob ispol'zovanie velichin ékskretsii vitaminov i ikh metabolitov v kachestve pokazateleĭ obespechennosti vitaminami B2, B6 i niatsinom.