Cell adhesion in the stromal regulation of haemopoiesis.
Haemopoiesis occurs in close physical contact with elements of the bone marrow stroma. This review examines some adhesion molecules which are expressed in haemopoietic environments. These molecules may act to maintain cell contact between haemopoietic progenitors and the cellular and extracellular matrix elements of the marrow stroma. A review is undertaken of several families of adhesion molecules and their ligands, including integrins, CD44, LEC-CAMs, CAMs and variant glycosylation patterns expressed by haemopoietic cells. Both CD44 and integrin receptors have been implicated in mediating important cellular interactions within the haemopoietic system and the significance of these and other molecules in haemopoiesis is discussed.
Clark
B R
BR
Gallagher
J T
JT
Dexter
T M
TM
D000595:Amino Acid Sequence; D000818:Animals; D001854:Bone Marrow Cells; D015815:Cell Adhesion Molecules / Q000502:physiology; D003238:Connective Tissue / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology; D006402:Hematologic Diseases / Q000503:physiopathology; D006410:Hematopoiesis / Q000502:physiology*; D016298:Hematopoietic Cell Growth Factors / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006413:Hematopoietic System / Q000033:anatomy & histology / Q000196:embryology; D006801:Humans; D016023:Integrins / Q000502:physiology; D037102:Lectins; D008221:Lymphoid Tissue / Q000033:anatomy & histology / Q000196:embryology; D051379:Mice; D008817:Mice, Mutant Strains; D008954:Models, Biological; D008969:Molecular Sequence Data; D009924:Organ Culture Techniques; D011509:Proteoglycans / Q000502:physiology; D016201:Receptors, Lymphocyte Homing / Q000502:physiology; D014714:Vertebrates / Q000502:physiology
D015815:Cell Adhesion Molecules; D016298:Hematopoietic Cell Growth Factors; D016023:Integrins; D037102:Lectins; D011509:Proteoglycans; D016201:Receptors, Lymphocyte Homing