A primate model for acute and late cerebral vasospasm: angiographic findings.
A subarachnoid haemorrhage (SAH) in the squirrel monkey was produced by injection of blood via a permanently implanted catheter connected to the cisterna magna and a cannula stereotactically inserted into the interpeduncular cistern. Repeated angiographic examinations of the vertebro-basilar and right internal carotid arteries revealed a biphasic vasospasm with a maximal acute spasm at ten minutes and maximal late spasm at six days after blood injection. The present study has shown that a reproducible biphasic vasospasm can be produced in the squirrel monkey and evaluated by repeated angiographic examinations. The model is suitable in the study of basic mechanisms underlying vasospasm in a primate and, due to the size of the animal, autoradiographic evaluation of the cerebral blood flow and metabolism can be performed at an acceptable cost.
Delgado-Zygmunt
T J
TJ
Neurosurgical Research Department, University Hospital, Lund, Sweden.
Arbab
M A
MA
Shiokawa
Y
Y
Svendgaard
N A
NA
D000818:Animals; D002533:Cerebral Angiography; D004195:Disease Models, Animal; D005260:Female; D007427:Intracranial Pressure / Q000502:physiology; D002546:Ischemic Attack, Transient / Q000000981:diagnostic imaging*; D008297:Male; D008793:Metrizamide; D012453:Saimiri; D013345:Subarachnoid Hemorrhage / Q000000981:diagnostic imaging; D014715:Vertebrobasilar Insufficiency / Q000000981:diagnostic imaging
D008793:Metrizamide