Further studies on the hematopoietic damage produced by a single dose of T-2 toxin in mice.
Previous studies revealed that a single dose of T-2 toxin produces a strong inhibition of the 59Fe incorporation into circulating erythrocytes in mice. In the present work it is shown that equivalent doses of T-2 toxin (0.30 mg/kg and above) can produce a relative depletion of granulocyte-macrophage colony-forming cells (CFU-GM) in the bone marrow of treated mice. In additional experiments, both the 59Fe uptake into erythrocytes and the bone marrow CFU-GM were measured as a function of dose and time after a single administration of T-2 toxin. It was found that the initial inhibitory effects are reverted between 24 h and 72 h and that in some cases there is even a significant increase over the normal values, indicating that there may be a compensatory activation of the hematopoietic system. The results presented here suggest that extremely small doses of T-2 toxin can produce a significant degree of bone marrow cytotoxicity and therefore even low level dietary contamination may be of concern.
Faifer
G C
GC
Laboratorio de Micotoxinas, Instituto de Patobiología, Castelar, Argentina.
Zabal
O
O
Godoy
H M
HM
D000818:Animals; D004032:Diet; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000378:metabolism; D005506:Food Contamination / Q000032:analysis; D006098:Granulocytes / Q000166:cytology / Q000187:drug effects; D006410:Hematopoiesis / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D006413:Hematopoietic System / Q000187:drug effects*; D007501:Iron / Q000493:pharmacokinetics / Q000494:pharmacology; D007504:Iron Radioisotopes; D008264:Macrophages / Q000166:cytology / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012680:Sensitivity and Specificity; D013605:T-2 Toxin / Q000032:analysis / Q000633:toxicity*; D013997:Time Factors; D014255:Trichothecenes / Q000633:toxicity
D007504:Iron Radioisotopes; D014255:Trichothecenes; D007501:Iron; D013605:T-2 Toxin