[The use of taktivin for modulating the functional activity of the neutrophilic granulocytes in patients with systemic lupus erythematosus].
The dynamics of the synthesis of active oxygen forms by neutrophilic granulocytes was studied and compared in patients with systemic lupus erythematosus (SLE) given conventional therapy (n = 14) and combined therapy with the use of tactivin (n = 17). Evaluation of spontaneous fluorescence of neutrophils (FN) and of that induced by suspension of the killed Staphylococcus culture revealed an increase of the latter one after tactivin treatment, which was accompanied by the regression of articular and cutaneous syndromes and trophic disorders. It has been discovered that the dynamics of FN in the treatment with the use of tactivin was dependent on the initial characteristics of the synthesis of active oxygen forms.
Romanov
V A
VA
Borodin
A G
AG
Krylov
V L
VL
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000936:Antigen-Antibody Complex / Q000097:blood; D005260:Female; D006801:Humans; D008163:Luminescent Measurements; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D010455:Peptides / Q000627:therapeutic use*; D013949:Thymus Extracts / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D000936:Antigen-Antibody Complex; D010455:Peptides; D013949:Thymus Extracts; C036191:T-activin
Primenenie taktivina dlia moduliatsii funktsional'noĭ aktivnosti neĭtrofil'nykh granulotsitov u bol'nykh sistemnoĭ krasnoĭ volchankoĭ.