Copper supplementation in the rat: preliminary observations on the clinical, hematological and histopathological profile.
Complete toxicological examinations in female rats fed an "anti-inflammatory" 200 ppm copper-containing diet for 30 and 58 days were performed. Copper was found to accumulate in liver, kidneys and paws; however, at the hematological, clinical chemical and histopathological levels, this treatment did not seem able to induce any toxic accumulation phenomenon in the examined rats.
Cristofori
P
P
Laboratorio di Patologia, Università degli Studi, Verona, Italia.
Terron
A
A
Marella
M
M
Moretti
U
U
Pasqualicchio
M
M
Velo
G P
GP
Milanino
R
R
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001772:Blood Cell Count / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003300:Copper / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D003404:Creatinine / Q000097:blood; D004032:Diet; D005260:Female; D006614:Hindlimb / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000637:Transaminases / Q000097:blood; D014508:Urea / Q000097:blood
D003300:Copper; D014508:Urea; D003404:Creatinine; D000637:Transaminases; D000469:Alkaline Phosphatase