title: Modulators of free radical activity in diabetes mellitus: role of ascorbic acid.
abstract: Free radical mechanisms are increasingly being implicated in the pathogenesis of tissue damage in diabetes. Various sources of free radicals may modulate oxidative stress in diabetes, including non-enzymatic glycosylation of proteins and monosaccharide autooxidation, polyol pathway activity, indirect production of free radicals through cell damage from other causes, and reduced antioxidant reserve. Ascorbic acid, which may be a principal modulator of free radical activity in diabetes, is shown to be consumed, presumably through free radical scavenging, thus preserving levels of other antioxidants such as glutathione.
authors.affiliation: University Department of Geriatric Medicine, University of Wales College of Medicine, Cardiff, UK.
authors.forename: A J
authors.initials: AJ
authors.lastname: Sinclair
authors.forename: J
authors.initials: J
authors.lastname: Lunec
authors.forename: A J
authors.initials: AJ
authors.lastname: Girling
authors.forename: A H
authors.initials: AH
authors.lastname: Barnett
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001205:Ascorbic Acid / Q000378:metabolism* / Q000494:pharmacology*; D003920:Diabetes Mellitus / Q000378:metabolism* / Q000473:pathology; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism / Q000473:pathology; D016166:Free Radical Scavengers; D005609:Free Radicals / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D008954:Models, Biological; D013012:Sorbitol / Q000378:metabolism
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D005609:Free Radicals; D013012:Sorbitol; D001205:Ascorbic Acid