title: Biologic properties of eugenol and zinc oxide-eugenol. A clinically oriented review.
abstract: Eugenol-containing dental materials are frequently used in clinical dentistry. When zinc oxide-eugenol (ZOE) is applied to a dentinal cavity, small quantities of eugenol diffuse through the dentin to the pulp. Low concentrations of eugenol exert anti-inflammatory and local anesthetic effects on the dental pulp. Thus use of ZOE temporary filling may facilitate pulpal healing; on the other hand, high eugenol concentrations are cytotoxic. Direct application of eugenol to pulp tissue may result in extensive tissue damage. The ability of ZOE-based endodontic sealers to influence periapical tissue healing is considered in view of eugenol's anti-inflammatory and toxic properties.
authors.affiliation: Division of Endodontics, School of Dental and Oral Surgery, Columbia University, New York, NY.
authors.forename: K
authors.initials: K
authors.lastname: Markowitz
authors.forename: M
authors.initials: M
authors.lastname: Moynihan
authors.forename: M
authors.initials: M
authors.lastname: Liu
authors.forename: S
authors.initials: S
authors.lastname: Kim
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D003782:Dental Pulp / Q000187:drug effects; D005054:Eugenol / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D012387:Root Canal Filling Materials / Q000737:chemistry* / Q000494:pharmacology; D015035:Zinc Oxide-Eugenol Cement / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D001672:Biocompatible Materials; D012387:Root Canal Filling Materials; D015035:Zinc Oxide-Eugenol Cement; D005054:Eugenol