[An experimental study of mitogen-stimulated blastogenic transformation and interleukin-2 in mice after burn injury].
In this study, mitogen-stimulated blastogenic transformation (MSBT) and interleukin 2 (IL-2) production by splenic lymphocytes in mice were measured at various time intervals after unanesthetized burn injury. The results showed that both MSBT and IL-2 production were suppressed after burn injury. There was a significant positive correlation between these two parameters. The postburn serum showed in vitro suppressive activity upon MSBT, IL-2 production and IL-2-IL-2R interaction of normal control. The results indicated that burn injury had a significant effect on lymphocytes.
Liang
H P
HP
Research Institute of Surgery, 3rd Medical College of PLA, Chongqing.
D000818:Animals; D002056:Burns / Q000276:immunology*; D005260:Female; D007376:Interleukin-2 / Q000096:biosynthesis*; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008934:Mitogens / Q000494:pharmacology; D013154:Spleen / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology*
D007376:Interleukin-2; D008934:Mitogens