[The prolonged use of calcium antagonists in myocardial infarct in rats: their effect on hemodynamics and the contractile function and morphology of the heart muscle].
Experiments on rats with myocardial infarction induced by occlusion of the left coronary artery were made to explore the influence of calcium antagonists injected intraperitoneally for a long time (daily, for 21 days) on hemodynamics, contractile function and morphology of the heart muscle. It has been shown that verapamil (0.5 mg/kg), diltiazem (2 mg/kg) and nimodipine (20 micrograms/kg) do not exert under those conditions any noticeable effect on pump and contractile heart functions. Administration of verapamil in a doze of 2 mg/kg enhanced heart failure. The drugs under study normalized the response of contractile heart function to volumetric load, which is related to a considerable measure to the acceleration of reparative processes in the myocardium.
Kazanova
G V
GV
Tsorin
I B
IB
Chichkanov
G G
GG
Zakharov
S P
SP
Shchegolev
A I
AI
Iavorskiĭ
A N
AN
Liubimov
B I
BI
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology / Q000627:therapeutic use*; D004110:Diltiazem / Q000494:pharmacology / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology*; D009553:Nimodipine / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D013997:Time Factors; D014700:Verapamil / Q000494:pharmacology / Q000627:therapeutic use
D002121:Calcium Channel Blockers; D009553:Nimodipine; D014700:Verapamil; D004110:Diltiazem
Dlitel'noe primenenie antagonistov kal'tsiia pri infarkte miokarda u krys: vliianie na gemodinamiku, sokratitel'nuiu funktsiiu i morfologiiu serdechnoĭ myshtsy.