title: The results of pouch surgery after ileo-anal anastomosis for inflammatory bowel disease: the manometric assessment of pouch continence and its reservoir function.
abstract: Anal sphincter function after restorative proctocolectomy has mainly been investigated by anal manometry. A significant decrease of basal pressure up to 45%, has been recorded postoperatively, possibly due to sphincter stretch during endoanal mucosectomy. Both abdominal mucosectomy and anastomosis at the level of the anorectal ring have been reported to prevent anal sphincter damage and lead to better continence. The striated sphincter is not significantly affected by the surgical procedure. Pouch-anal inhibitory reflex is partly maintained in the presence of a rectal cuff which leaves the ganglionic plexus unaltered; a satisfactory continence is also retained in the absence of the reflex when the rectum is totally excised. Pouch capacity, compliance and motility have been investigated by endoluminal balloon and probes. Pouch emptying has been studied by a "porridge" test, by a semi-solid medium labelled with technetium-99, and by other methods. A more effective storage function is achieved by large capacity reservoirs which lower the bowel frequency. The motor response to pouch distension, to a meal, and to pharmacological stimuli is usually counteracted by sphincter contraction. Ileal hypermotility may lead to fecal leakage mainly in the presence of weak sphincters. Poor pouch emptying may be related to an anal stricture.
authors.affiliation: Istituto di Clinica Chirurgica, Università Cattolica, Roma, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Pescatori
mesh_terms: D000293:Adolescent; D000328:Adult; D001003:Anal Canal / Q000502:physiology / Q000601:surgery*; D000714:Anastomosis, Surgical; D005769:Gastrointestinal Motility; D006801:Humans; D007082:Ileum / Q000502:physiology / Q000601:surgery*; D015212:Inflammatory Bowel Diseases / Q000503:physiopathology / Q000601:surgery*; D008365:Manometry; D008875:Middle Aged; D016737:Proctocolectomy, Restorative / Q000379:methods; D012146:Rest