title: Use of morphine sulfate (MS Contin) in patients with burns: a pilot study.
abstract: Morphine sulfate (MS Contin), a proven analgesic in the treatment of cancer pain and chronic benign pain, seems to be a good analgesic for the treatment of burn pain. MS Contin is morphine sulfate incorporated in a wax cellulose matrix delivery system. This wax cellulose delivery system gives MS Contin its duration of action. Ten patients were enrolled in an open-labeled, nonrandomized study. The study was designed to examine the analgesic efficacy of MS Contin in the burn population. Each patient remained in the study for 6 days. The efficacy of the analgesic regimen was subjectively measured by the visual pain scale. The MS Contin group was retrospectively compared with a group of patients who were given continuous intravenous infusions of morphine. The two groups were matched according to age, burn size, surgical procedures, and hospital stay. The analgesic qualities of MS Contin were comparable to those of continuous intravenous morphine sulfate infusions. MS Contin is a possible candidate for the treatment of patients with burn pain because of its analgesic qualities, oral dosing, and duration of action.
authors.affiliation: Department of Anesthesiology, University of South Alabama, Mobile 36617.
authors.forename: L
authors.initials: L
authors.lastname: Alexander
authors.forename: R
authors.initials: R
authors.lastname: Wolman
authors.forename: C
authors.initials: C
authors.lastname: Blache
authors.forename: R P
authors.initials: RP
authors.lastname: Grandy
authors.forename: D
authors.initials: D
authors.lastname: Dyess
authors.forename: A
authors.initials: A
authors.lastname: Luterman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002056:Burns / Q000503:physiopathology*; D002648:Child; D016503:Drug Delivery Systems; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy*; D010865:Pilot Projects; D012189:Retrospective Studies
chemical_list: D009020:Morphine