Encoding of a homolog of the IFN-gamma receptor by myxoma virus.
Many poxvirus-encoded virulence factors have been identified as proteins that are secreted from infected cells. The major secreted protein (37 kilodaltons) from cells infected with myxoma virus is encoded by the M-T7 open reading frame. This protein has significant sequence similarity to the human and mouse receptors for interferon-gamma (IFN-gamma). Furthermore, the myxoma M-T7 protein specifically binds rabbit IFN-gamma and inhibits the biological activity of extracellular IFN-gamma, one of the key regulatory cytokines in the host immune response against viral infections.
Upton
C
C
Department of Biochemistry, University of Alberta, Edmonton, Canada.
Mossman
K
K
McFadden
G
G
D000595:Amino Acid Sequence; D000818:Animals; D002478:Cells, Cultured; D003001:Cloning, Molecular; D005814:Genes, Viral; D066298:In Vitro Techniques; D007371:Interferon-gamma / Q000378:metabolism; D008969:Molecular Sequence Data; D009233:Myxoma virus / Q000235:genetics* / Q000472:pathogenicity; D011485:Protein Binding; D011817:Rabbits; D017471:Receptors, Interferon / Q000235:genetics*; D015183:Restriction Mapping; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014762:Viral Interference; D014764:Viral Proteins / Q000235:genetics*; D015678:Viral Structural Proteins / Q000235:genetics*
C091989:M-T7 protein, Myxoma virus; D017471:Receptors, Interferon; D014764:Viral Proteins; D015678:Viral Structural Proteins; D007371:Interferon-gamma