[The antihypoxic and radioprotective properties of selective adenosine receptor agonists].
The selective A1- and A2-receptor agonists L-PIA (ED50 = 0.55-0.78 mmole/kg) and NEGA (D50 = 0.05-0.1 mmole/kg) possess high antihypoxic and radioprotective effects. A2-subtype receptors may be involved in the antihypoxic and radioprotective effects of adenosine analogs.
Ol'khovskiĭ
I A
IA
Kulinskiĭ
V I
VI
Klimova
A D
AD
Lidak
M Iu
MIu
Tsalmane
L V
LV
D000208:Acute Disease; D000241:Adenosine / Q000031:analogs & derivatives / Q000627:therapeutic use; D019830:Adenosine-5'-(N-ethylcarboxamide); D000818:Animals; D004353:Drug Evaluation, Preclinical; D005260:Female; D000860:Hypoxia / Q000188:drug therapy* / Q000401:mortality; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010660:Phenylisopropyladenosine / Q000627:therapeutic use; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000401:mortality; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D011983:Receptors, Purinergic / Q000187:drug effects*
D011837:Radiation-Protective Agents; D011983:Receptors, Purinergic; D010660:Phenylisopropyladenosine; D019830:Adenosine-5'-(N-ethylcarboxamide); D000241:Adenosine
Protivogipoksicheskie i radioprotektornye svoĭstva selektivnykh agonistov adenozinovykh retseptorov.