The hepatitis B virus X protein transactivation of c-fos and c-myc proto-oncogenes is mediated by multiple transcription factors.
We have constructed two expression vectors in order to study the action of the HBV 17 Kd X protein on the c-fos and c-myc promoters. The results show that the promoters contain multiple elements that respond to X protein, suggesting involvement of multiple transcription factors. The exact mechanism of the interaction remains elusive, but our data allow speculation about the factors that may be influenced.
Avantaggiati
M L
ML
I Clinica Medica, Fondazione Andrea Cesalpino Policlinico Umberto I, Rome, Italy.
Balsano
C
C
Natoli
G
G
De Marzio
E
E
Will
H
H
Elfassi
E
E
Levrero
M
M
D015500:Chloramphenicol O-Acetyltransferase / Q000235:genetics; D004252:DNA Mutational Analysis; D016762:Genes, fos / Q000235:genetics*; D016259:Genes, myc / Q000235:genetics*; D005822:Genetic Vectors / Q000235:genetics; D006515:Hepatitis B virus / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics; D011993:Recombinant Fusion Proteins; D014157:Transcription Factors / Q000235:genetics*; D015533:Transcriptional Activation
D011993:Recombinant Fusion Proteins; D014157:Transcription Factors; D015500:Chloramphenicol O-Acetyltransferase