[Gastric and hematologic changes in patients with gastric parietal cell autoantibodies and non-insulin-dependent diabetes mellitus].
Gastric abnormalities are more common in diabetics than in the normal population. They seem to be related to gastric parietal cell autoantibodies (GPCA). We have studied 168 patients affected with non-insulin-dependent diabetes mellitus (NIDDM), and assessed the GPCA in the serum and haematologic disorders. We have also assessed the endoscopic and histological findings of atrophic gastritis in patients with GPCA. GPCA were found in 15.74% of diabetic patients and in 2% of a control group of blood donors. 80% of GPCA positive patients showed signs of atrophic gastritis. Such presence of GPCA seems to be a good marker to identify patients affected by atrophic gastritis and its complications.
Corti
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F
Divisione Medica, USSL 3, Versilia.
Lera
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M
Meniconi
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RM
Lucarini
P
P
Gustinucci
R
R
D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000276:immunology*; D005260:Female; D005293:Ferritins / Q000097:blood; D005755:Gastrins / Q000097:blood; D005757:Gastritis, Atrophic / Q000097:blood / Q000150:complications / Q000276:immunology*; D006801:Humans; D007501:Iron / Q000097:blood; D007515:Islets of Langerhans / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010295:Parietal Cells, Gastric / Q000276:immunology*
D001323:Autoantibodies; D005755:Gastrins; D005293:Ferritins; D007501:Iron
Alterazioni gastriche ed ematologiche in pazienti con autoanticorpi anticellule parietali gastriche affetti da diabete mellito non insulino dipendente.