title: [Creutzfeldt-Jakob disease in 4 children treated with growth hormone].
abstract: Creutzfeldt-Jakob disease was diagnosed in four growth hormone recipients at the age of 10, 11, 18 and 19 years. To our knowledge, the two first cases are the first instances of Creutzfeldt-Jakob disease recorded in children. Three of them were still being treated with synthetic hormone at the onset of the disease. Neurological disorders: ataxia and diplopia, appeared first, dementia and myoclonus appeared later. Eighteen cases of Creutzfeldt-Jakob disease in growth hormone recipients are now recorded, and the present risk of Creutzfeldt-Jakob disease in pituitary growth recipients is estimated to be 1/300. Because of the long incubation period, new cases are to be feared. Other causes of iatrogenic Creutzfeldt-Jakob disease are reviewed. These facts incite to consider carefully using products of human origin in human therapy. The interactions between growth hormone, prion and host's genomic make-up are still not clear.
authors.affiliation: Service de Pédiatrie, Hôpital Trousseau, Paris.
authors.forename: T
authors.initials: T
authors.lastname: Billette de Villemeur
authors.forename: M
authors.initials: M
authors.lastname: Gourmelen
authors.forename: P
authors.initials: P
authors.lastname: Beauvais
authors.forename: D
authors.initials: D
authors.lastname: Rodriguez
authors.forename: G
authors.initials: G
authors.lastname: Vaudour
authors.forename: J P
authors.initials: JP
authors.lastname: Deslys
authors.forename: D
authors.initials: D
authors.lastname: Dormont
authors.forename: P
authors.initials: P
authors.lastname: Richard
authors.forename: J M
authors.initials: JM
authors.lastname: Richardet
mesh_terms: D000293:Adolescent; D002648:Child; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics; D004340:Drug Contamination; D004569:Electroencephalography; D005260:Female; D006130:Growth Disorders / Q000628:therapy; D013006:Growth Hormone / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007049:Iatrogenic Disease; D008297:Male; D011328:Prions / Q000472:pathogenicity; D013997:Time Factors
chemical_list: D011328:Prions; D013006:Growth Hormone
vernacular_title: Maladie de Creutzfeldt-Jakob chez quatre enfants traités par hormone de croissance.