Monoamine oxidase-B in motor cortex: changes in amyotrophic lateral sclerosis.
The occurrence of monoamine oxidase-B in cerebral cortex and white matter in brains from three patients with the diagnosis of amyotrophic lateral sclerosis and three controls was quantified by means of an autoradiographical method. [3H]L-Deprenyl, an irreversible and selective monoamine oxidase-B inhibitor, was used as ligand and the autoradiographs were analysed by computer-assisted densitometry. In both amyotrophic lateral sclerosis and control cerebral cortex, lamina I showed the highest, laminae II and III intermediate, laminae IV, V and VI the lowest [3H]L-deprenyl binding. White matter showed about one-third of the binding in the cortex. Amyotrophic lateral sclerosis cases showed significantly higher binding of [3H]L-deprenyl in all the cortex laminae of the pre- and postcentral gyri. There was no difference in the binding between the amyotrophic lateral sclerosis cases and the controls in area 7 of the occipital cortex, an area which is relatively spared in amyotrophic lateral sclerosis.
Ekblom
J
J
Department of Neurology, University Hospital, Uppsala, Sweden.
Jossan
S S
SS
Gillberg
P G
PG
Oreland
L
L
Aquilonius
S M
SM
D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000201:enzymology*; D001345:Autoradiography; D001921:Brain / Q000201:enzymology*; D002540:Cerebral Cortex / Q000201:enzymology*; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000032:analysis / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000032:analysis / Q000378:metabolism*; D012642:Selegiline / Q000378:metabolism*; D014316:Tritium
D007527:Isoenzymes; D014316:Tritium; D012642:Selegiline; D008995:Monoamine Oxidase