[The radioprotective and antioxidant properties of solubilized alpha-tocopherol acetate].
A single intravenous administration of solubilized alpha-tocopherol acetate in a dose of 1 mg/kg to CBA x C57Bl x F1 male mice 3 and 24 hours before radiation was demonstrated to increase 30-day survival rates in the animals. Oily alpha-tocopherol acetate had the identical effects when the agent was intramuscularly given in a dose of 10 mg/kg. There was a rise in peripheral leukocyte counts 0.5 hour after solubilized alpha-tocopherol acetate administration. The antioxidative activity of the solubilized agent was 3.3 times as high as that the routine agent when attacking Tween 80. The higher radioprotective activity of solubilized alpha-tocopherol acetate is accounted for by its enhanced bioavailability, antioxidative activity and effects on the factors of nonspecific body's resistance.
Samoĭlov
A V
AV
Seĭfulla
R D
RD
Kamaev
N O
NO
Lukoianova
T I
TI
Gukasov
V M
VM
Belous
M V
MV
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000188:drug therapy / Q000401:mortality; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D012995:Solubility; D013997:Time Factors; D024505:Tocopherols; D014810:Vitamin E / Q000008:administration & dosage / Q000031:analogs & derivatives*; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D000975:Antioxidants; D011837:Radiation-Protective Agents; D014810:Vitamin E; D024502:alpha-Tocopherol; D024505:Tocopherols
Radiozashchitnye i antioksidantnye svoĭstva soliubilizirovannogo al'fa-tokoferola atsetata.