Transplantation of half kidneys in swine: I. Long-term survivors of hemirenal autotransplants.
We describe a novel model of hemirenal transplantation in swine wherein one-half of one kidney is autotransplanted by modifications of standard vascular anastomoses and ureteropyelostomy. Two pigs with hemirenal transplants performed in this manner have not only survived but have grown normally and had decreased but stable renal function for more than 1 year. The model confirms that one-fourth of the total renal mass is sufficient to sustain life and growth in pigs. It is anticipated that this model could be used to study the effects of renal ablation on remnant nephrons in pigs.
Kittur
D S
DS
Johns Hopkins University School of Medicine, Baltimore, MD.
Petronis
J
J
French
A W
AW
Adler
W
W
D000714:Anastomosis, Surgical / Q000662:veterinary; D000818:Animals; D005260:Female; D005500:Follow-Up Studies; D007668:Kidney / Q000098:blood supply; D016030:Kidney Transplantation / Q000379:methods / Q000502:physiology / Q000662:veterinary*; D013552:Swine / Q000601:surgery*; D014182:Transplantation, Autologous / Q000662:veterinary