title: Instabilities of metabolic regulations in aging.
abstract: 1) That non-invasive NMR and optical methods can a) quantify the work stress on mitochondria for ATP production, and b) indicate the tissue O2 tension in the capillary bed that is responsible for the rate of radical generation. 2) That free radical damage to mitochondrial function can be quantified by reciprocal plots of inverse slope giving the extrapolated Vm of mitochondria. 3) That a particular genetically deficient individual requiring high dosages of menadione has survived over 9 years. 4) That mitochondrial deficiency leads to an exercise hyperoxia.
authors.affiliation: Department of Biochemistry and Biophysics, Johnson Foundation, University of Pennsylvania, Philadelphia 19104.
authors.forename: B
authors.initials: B
authors.lastname: Chance
authors.forename: W W
authors.initials: WW
authors.lastname: Bank
authors.forename: C
authors.initials: C
authors.lastname: Zhang
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000375:Aging / Q000378:metabolism*; D000818:Animals; D005609:Free Radicals / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological; D009132:Muscles / Q000378:metabolism; D005082:Physical Exertion
chemical_list: D005609:Free Radicals; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate