title: The distribution of the tumour photosensitizers Zn(II)-phthalocyanine and Sn(IV)-etiopurpurin among rabbit plasma proteins.
abstract: Zn-phthalocyanine (ZnPc) and Sn-etiopurpurin (SnET2) incorporated in unilamellar liposomes or solubilized in a Cremophor-EL emulsion have been incubated in vitro with rabbit plasma or intravenously administered to rabbits. Ultracentrifugation and chromatographic analysis of the plasma showed that ZnPc and SnET2 are mainly released to lipoproteins; within the lipoprotein family, both dyes are preferentially bound by low-density (LDL) and high-density (HDL) lipoproteins. The amount of dye bound with these two lipoprotein classes was related to their relative concentration in the plasma; in most cases a larger amount of photosensitizer was bound to HDL as compared to LDL on a protein concentration basis.
authors.affiliation: Department of Biology, University of Padua, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Polo
authors.forename: E
authors.initials: E
authors.lastname: Reddi
authors.forename: G M
authors.initials: GM
authors.lastname: Garbo
authors.forename: A R
authors.initials: AR
authors.lastname: Morgan
authors.forename: G
authors.initials: G
authors.lastname: Jori
mesh_terms: D015060:1,2-Dipalmitoylphosphatidylcholine; D000818:Animals; D001798:Blood Proteins / Q000302:isolation & purification / Q000378:metabolism*; D004655:Emulsions; D005990:Glycerol / Q000031:analogs & derivatives; D007211:Indoles / Q000097:blood*; D054833:Isoindoles; D008074:Lipoproteins / Q000097:blood* / Q000302:isolation & purification; D008081:Liposomes; D009942:Organometallic Compounds / Q000097:blood*; D014677:Pharmaceutical Vehicles; D011166:Porphyrins / Q000097:blood; D011817:Rabbits; D011838:Radiation-Sensitizing Agents / Q000378:metabolism*; D017967:Zinc Compounds
chemical_list: D001798:Blood Proteins; D004655:Emulsions; D007211:Indoles; D054833:Isoindoles; D008074:Lipoproteins; D008081:Liposomes; D009942:Organometallic Compounds; D014677:Pharmaceutical Vehicles; D011166:Porphyrins; D011838:Radiation-Sensitizing Agents; D017967:Zinc Compounds; C052159:Zn(II)-phthalocyanine; D015060:1,2-Dipalmitoylphosphatidylcholine; C063166:tin etiopurpurin; C000515:cremophor EL; D005990:Glycerol