The kallikrein-kinin system in cardiac tissue.
Kallikrein and minute amounts of kininogen have been found in rat cardiac tissue. The mRNA for kallikrein was also determined by the polymerase chain reaction using KK-specific probe. The existence of an intrinsic kallikrein-kinin system in the heart raises the possibility that the enzyme-peptide system is involved in local regulation of cardiac function and metabolism.
Nolly
H L
HL
Hypertension and Vascular Res. Div., Henry Ford Hospital, Detroit, MI.
Saed
G
G
Scicli
G
G
Carretero
O A
OA
Scicli
A G
AG
D000818:Animals; D000906:Antibodies; D015152:Blotting, Northern; D002846:Chromatography, Affinity; D002850:Chromatography, Gel; D015342:DNA Probes; D004789:Enzyme Activation; D066298:In Vitro Techniques; D007610:Kallikreins / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D007700:Kinetics; D007704:Kininogens / Q000032:analysis / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014357:Trypsin / Q000378:metabolism
D000906:Antibodies; D015342:DNA Probes; D007704:Kininogens; D012333:RNA, Messenger; D007610:Kallikreins; D014357:Trypsin