[Determination of estrogen receptor status in breast cancer by immunocytochemical examination of fine-needle aspirates].
Estrogen receptor status was determined by immunocytochemical examination of fine-needle aspirates in 109 cases of primary invasive breast carcinoma. The results were compared with those from biochemical determination performed on tumor cytosols. Positive agreement was found between qualitative determination (positive/negative) by the two methods in 83% of the cases, and after semiquantitative stratification into three groups the results corresponded in 76%. The predictive value of a positive result on fine-needle aspirate was 96%, and 57% of a negative result. It is concluded that immunocytochemical determination of estrogen receptor status of breast carcinomas on fine-needle aspirate with the applied technique cannot replace the current standard biochemical method.
Balslev
E
E
Patologisk afdeling, Bispebjerg Hospital, København.
Nielsen
M
M
Jensen
O J
OJ
Francis
D
D
Thorpe
S M
SM
D000368:Aged; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000378:metabolism*
D011960:Receptors, Estrogen
Bestemmelse af mammakarcinomers østrogenreceptorstatus ved immuncytokemisk undersøgelse på finnålsaspirat.