[The regulation of DNA repair processes in mammalian cells. III. The effect of epidermal growth factor on the postradiation recovery of the cell cycle in human A 431 cells and embryonic fibroblasts].
Recovery of the cell cycle in cells A 431 and in human embryo fibroblasts (EFH) differs much. Unlike EFH, A 431 cells have: 1) synchronized exit of cells from G1 into S phase after 5 Gr irradiation; 2) G2-block; 3) much less manifestation of these two phenomena in the presence of EGF; 4) a lesser effectiveness of the repair of DNA single-strand breaks. EGF stimulation of the repair of radiation-induced DNA lesions, SSB in particular, may be of great importance for the postirradiation cell cycle recovery.
Kirillova
T V
TV
Seregina
T B
TB
Bil'din
V N
VN
D002250:Carbon Radioisotopes; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D002453:Cell Cycle / Q000187:drug effects / Q000528:radiation effects; D002460:Cell Line; D002478:Cells, Cultured / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D004249:DNA Damage / Q000187:drug effects*; D004260:DNA Repair / Q000187:drug effects* / Q000528:radiation effects; D004273:DNA, Neoplasm / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D004277:DNA, Single-Stranded / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D004622:Embryo, Mammalian; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D006801:Humans; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects
D002250:Carbon Radioisotopes; D004273:DNA, Neoplasm; D004277:DNA, Single-Stranded; D004815:Epidermal Growth Factor; D013936:Thymidine
Reguliatsiia protsessov reparatsii DNK v kletkakh mlekopitaiushchikh. III. Vliianie épidermal'nogo faktora rosta na postradiatsionnoe vosstanovlenie kletochnogo tsikla u kletok A 431 i émbrional'nykh fibroblastov cheloveka.