The pharmacological differences and similarities between stress- and ethanol-induced gastric mucosal damage.
Stress- and ethanol-induced gastric mucosal damage are the two commonly used ulcer models in animals. They share some of the similarities but also have differences in the etiology of gastric ulceration. This article reviews the influences of various protective drugs on these two types of gastric damage in rats. Verapamil (a calcium antagonist) or N-ethylmaleimide (a sulfhydryl depletor) prevents cold restraint-, but potentiates ethanol-provoked gastric lesion formation. N-Acetylcysteine (a mucolytic agent) and acetaminophen (an antipyretic analgesic) have the opposite actions. Prostaglandins provide a much better antiulcer effect on ethanol-induced lesions. Cimetidine (a histamine H2-receptor antagonist) prevents only stress-induced mucosal damage. These differences in drug actions indicate that stress and ethanol may have dissimilar ulcerogenic mechanisms in rats. On the other hand, carbenoxolone (a mucus inducer), histamine H1-receptor antagonists, leukotriene inhibitors (FPL 55712 and nordihydroguaiaretic acid) and mast cell stabilizers (like zinc compounds, sodium cromoglycate, FPL 52694 and ketotifen), all protect against gastric mucosal damage by stress or ethanol in rats. However, the role of gastric sulfhydryls in both types of gastric lesions is still controversial. These findings imply that the two types of lesion formation share some of the ulcerogenic mechanisms. This communication attempts to analyze the various findings and to relate them to the etiology of stress and ethanol-induced gastric lesions. It also summarizes the uses, and the antiulcer mechanisms, of the drugs that have been studied utilizing these two animal ulcer models, and suggests their possible implications in man.
Cho
C H
CH
Department of Pharmacology, Faculty of Medicine, University of Hong Kong.
Ogle
C W
CW
D000082:Acetaminophen / Q000494:pharmacology; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology; D003080:Cold Temperature; D004195:Disease Models, Animal; D000431:Ethanol; D005753:Gastric Mucosa / Q000187:drug effects*; D006633:Histamine Antagonists / Q000494:pharmacology; D015289:Leukotrienes / Q000494:pharmacology; D011453:Prostaglandins / Q000494:pharmacology; D013276:Stomach Ulcer / Q000209:etiology* / Q000517:prevention & control; D013312:Stress, Physiological; D013439:Sulfhydryl Reagents / Q000494:pharmacology
D000897:Anti-Ulcer Agents; D002121:Calcium Channel Blockers; D006633:Histamine Antagonists; D015289:Leukotrienes; D011453:Prostaglandins; D013439:Sulfhydryl Reagents; D000082:Acetaminophen; D000431:Ethanol