title: The nuclear membrane.
abstract: The nuclear membrane forms a major barrier within the cell, permitting levels of regulation not found in prokaryotes. The dynamics and diverse functions of the nuclear membrane and its associated structures are considered in this review. The role of the nuclear pore complex in selective transport across the nuclear membrane has been studied to a considerable degree; however, many crucial questions remain. Components of a signal transduction mechanism are associated with the nucleus, suggesting that nuclear functions may be influenced directly by this system. The involvement of the heat shock cognate protein Hsc70 in nuclear protein import is discussed, and a specific signal-presentation role for this protein is proposed.
authors.affiliation: Wellcome/CRC Institute, Cambridge, United Kingdom.
authors.forename: C
authors.initials: C
authors.lastname: Dingwall
authors.forename: R
authors.initials: R
authors.lastname: Laskey
mesh_terms: D000818:Animals; D001692:Biological Transport; D004261:DNA Replication / Q000502:physiology; D006360:Heat-Shock Proteins / Q000502:physiology; D009685:Nuclear Envelope / Q000502:physiology* / Q000648:ultrastructure; D015398:Signal Transduction / Q000502:physiology
chemical_list: D006360:Heat-Shock Proteins