title: A second-generation linkage map of the human genome.
abstract: A linkage map of the human genome has been constructed based on the segregation analysis of 814 newly characterized polymorphic loci containing short tracts of (C-A)n repeats in a panel of DNAs from eight large families. Statistical linkage analysis placed 813 of the markers into 23 linkage groups corresponding to the 22 autosomes and the X chromosome; 605 show a heterozygosity above 0.7 and 553 could be ordered with odds ratios above 1,000:1. The distance spanned corresponds to approximately 90% of the estimated length of the human genome.
authors.affiliation: Genethon, Evry, France.
authors.forename: J
authors.initials: J
authors.lastname: Weissenbach
authors.forename: G
authors.initials: G
authors.lastname: Gyapay
authors.forename: C
authors.initials: C
authors.lastname: Dib
authors.forename: A
authors.initials: A
authors.lastname: Vignal
authors.forename: J
authors.initials: J
authors.lastname: Morissette
authors.forename: P
authors.initials: P
authors.lastname: Millasseau
authors.forename: G
authors.initials: G
authors.lastname: Vaysseix
authors.forename: M
authors.initials: M
authors.lastname: Lathrop
mesh_terms: D002874:Chromosome Mapping; D002877:Chromosomes, Human; D004247:DNA / Q000235:genetics; D015723:Gene Library; D008040:Genetic Linkage; D005819:Genetic Markers; D015894:Genome, Human; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D016133:Polymerase Chain Reaction; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D005819:Genetic Markers; D004247:DNA