title: Simple hypothermic retrograde cerebral perfusion during aortic arch surgery.
abstract: We have found that retrograde cerebral perfusion can be performed by simply elevating central venous pressure during aortic arch surgery. During hypothermia (15 degrees C) venous blood rich in oxygen perfuses the brain, while the lower half of the body is perfused with the descending aorta occluded. Fourteen cases of aortic arch aneurysm (11 males, 3 females) were treated by this method and evaluated. Median and lateral thoracotomies were performed in 6 and 8 cases, respectively. Cerebral circulatory arrest time was 65 +/- 14 min (32-93 min), and significant oxygen and lactate extraction were noted in the brain. Eleven cases showed no neurologic deficit, but loss of consciousness due to other causes occurred in 3. In conclusion, this method maintained the aerobic metabolism of the brain and protected it during prolonged cerebral circulatory arrest, simplifying the procedure and permitting both median and lateral approaches.
authors.affiliation: Division of Cardiovascular Surgery, Showa General Hospital, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Takamoto
authors.forename: T
authors.initials: T
authors.lastname: Matsuda
authors.forename: M
authors.initials: M
authors.lastname: Harada
authors.forename: Y
authors.initials: Y
authors.lastname: Shimamura
authors.forename: S
authors.initials: S
authors.lastname: Miyata
mesh_terms: D000367:Age Factors; D000368:Aged; D017545:Aortic Aneurysm, Thoracic / Q000378:metabolism / Q000401:mortality / Q000601:surgery*; D001784:Blood Gas Analysis; D001921:Brain / Q000098:blood supply* / Q000378:metabolism; D002315:Cardiopulmonary Bypass / Q000295:instrumentation / Q000379:methods* / Q000592:standards; D005069:Evaluation Studies as Topic; D005260:Female; D017052:Hospital Mortality; D006769:Hospitals, General; D006801:Humans; D007036:Hypothermia, Induced / Q000295:instrumentation / Q000379:methods* / Q000592:standards; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008297:Male; D008875:Middle Aged; D010092:Oximetry; D010477:Perfusion / Q000295:instrumentation / Q000379:methods* / Q000592:standards; D013997:Time Factors; D014041:Tokyo / Q000453:epidemiology; D016896:Treatment Outcome
chemical_list: D007773:Lactates; D019344:Lactic Acid