Isradipine is able to separate morphine-induced analgesia and place conditioning.
The effect of isradipine, a dihydropyridine calcium antagonist, on morphine-induced place preference and analgesia in rats and mice was studied. Isradipine (0.6-5.0 mg/kg s.c.) inhibited an acquisition of morphine-induced place preference in rats and mice in a dose-related manner. Isradipine did not affect or strengthen morphine-induced analgesia as measured by tail-clip and hot-plate tests in mice and tail-clip and tail-flick tests in rats. The results suggest that analgesic and reinforcing effects of morphine might be pharmacologically separated by isradipine.
Kuzmin
A
A
Laboratory of Pharmacology of Narcotics, Pavlov Medical Institute, St-Petersburg, Russia.
Patkina
N
N
Pchelintsev
M
M
Zvartau
E
E
D000698:Analgesia; D000818:Animals; D003213:Conditioning, Psychological / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D017275:Isradipine / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D010146:Pain / Q000503:physiopathology; D051381:Rats; D012054:Reinforcement, Psychology
D009020:Morphine; D017275:Isradipine