[Comparison of antiarrhythmic effects of IHC-72 (an iodonium-72), lidocaine and verapamil].
The antiarrhythmic actions of 3,6-dimethylamino-dibenzopyridonium edetate (IHC-72), lidocaine (Lid) and verapamil (Ver) on several models Were compared at equitoxic doses (equal fraction of LD50). The action of IHC-72 against aconitine induced arrhythmia was similar to that of Lid but stronger than that of Ver in anesthetized rats. The effect of IHC-72 on ouabain induced arrhythmia was also similar to that of Lid, but weaker than that of Ver in anesthetized guinea pigs. The activity of IHC-72 to raise electrical ventricular fibrillation thresholds (VFT) was weaker than that of Lid and Ver. The effects of IHC-72 in decreasing the incidence of ventricular premature beat(VP B), ventricular tachycardia (VT), ventricular fibrillation (VF) and shortening the duration of VT yielded by reperfusion were similar to those of Lid anf Ver in vivo.
Ji
G J
GJ
Department of Pharmacology, Fourth Military Medical University, Xian.
Zhao
D H
DH
Liu
D Q
DQ
Sheng
B H
BH
D000157:Aconitine; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000209:etiology / Q000517:prevention & control*; D004492:Edetic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D005260:Female; D006168:Guinea Pigs; D008012:Lidocaine / Q000627:therapeutic use; D008297:Male; D051379:Mice; D015428:Myocardial Reperfusion Injury / Q000150:complications; D009861:Onium Compounds / Q000627:therapeutic use* / Q000633:toxicity; D010042:Ouabain; D051381:Rats; D011919:Rats, Inbred Strains; D014693:Ventricular Fibrillation / Q000139:chemically induced / Q000517:prevention & control; D014700:Verapamil / Q000627:therapeutic use
D000889:Anti-Arrhythmia Agents; D009861:Onium Compounds; C077594:3,6-dimethylaminodibenzopyridonium edetate; D010042:Ouabain; D008012:Lidocaine; D004492:Edetic Acid; D014700:Verapamil; D000157:Aconitine