Simultaneous determination of amiodarone and desethylamiodarone in human plasma by high performance liquid chromatography.
A rapid, sensitive and specific reversed phase HPLC method for the simultaneous assay of amiodarone and its major metabolite desethylamiodarone in human serum has been developed. This method is suitable for pharmacokinetic studies and for monitoring of the drug and metabolite concentrations in serum of patients on both short and long-term therapy with amiodarone.
Mamolo
M G
MG
Dipartimento di Scienze Farmaceutiche, Facoltà di Farmacia Università degli Studi, Trieste, Italia.
Vio
L
L
Furlan
G
G
D000638:Amiodarone / Q000031:analogs & derivatives* / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D006801:Humans
C036116:desethylamiodarone; D000638:Amiodarone