Teratological assessment of glutaraldehyde in rats by gastric intubation.
Pregnant rats were given glutaraldehyde (GA) by gastric intubation at a dose of 0, 25, 50 or 100 mg/kg on days 6-15 of pregnancy. Maternal toxicity occurred in the 100 mg/kg group as evidenced by a significant increase in maternal death and a significant decrease in maternal body weight gain and food consumption. A significantly lowered fetal weight was also found in the 100 mg/kg group. No significant change induced by GA was detected in the incidence of postimplantation loss. Morphologic examinations of fetuses revealed no evidence of teratogenicity of GA. It could be concluded that GA has no teratogenic effects on rat offspring even at a dose which induced severe maternal toxicity.
Ema
M
M
National Institute of Hygienic Sciences, Osaka Branch, Japan.
Itami
T
T
Kawasaki
H
H
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005314:Embryonic and Fetal Development / Q000187:drug effects; D005260:Female; D005976:Glutaral / Q000008:administration & dosage / Q000633:toxicity*; D007441:Intubation, Gastrointestinal; D008431:Maternal-Fetal Exchange; D009026:Mortality; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar
D005976:Glutaral