Block copolymers as drug carriers.
The main subject of this review is to describe the concept and strategy of utilizing block copolymers as drug carriers and to present a perspective for this utilization. The first section points out preferable properties of block copolymers as drug carriers with a brief survey on classifications and synthesis of block copolymers and specifies the merits of block copolymers for this purpose in the historical background of polymeric drug carriers. The second section introduces several studies using block copolymers as drug carriers. These studies contain surface modification of microspheres with block copolymers, polymeric micelles, and a conjugate of an antibody and block copolymer. In conclusion, it is determined that block copolymers possess a high potential for use as drug carriers irrespective of some difficulties in their synthesis.
Yokoyama
M
M
Institute of Biomedical Engineering, Tokyo Women's Medical College, Japan.
D000818:Animals; D004337:Drug Carriers / Q000737:chemistry; D006801:Humans; D011108:Polymers
D004337:Drug Carriers; D011108:Polymers