title: Modification of calcium flux of twitch skeletal muscle in mice subjected to 20% body surface area burn.
abstract: One systemic effect of burn trauma is skeletal muscle weakness. This is the result of changes in second messenger systems involving calcium (Ca2+). Kinetic analysis of Ca2+ from cellular compartments of skeletal muscle of mice that were subjected to small burn injury (20% body surface area) was performed. Muscles of the burn group showed an increased 45Ca2+ uptake maxima compared with those of time-matched control groups. Also, 45Ca2+ efflux analysis showed a lack of differentiation between electrically stimulated tissues and nonstimulated tissues that was easily observed in time-matched control groups. This lack of differentiation indicated changes in intracellular compartmentation. It can be speculated that burn trauma may have a regulatory role in the excitation-contraction coupling mechanism by altering myoplasmic levels of Ca2+ even before skeletal muscle dysfunction occurs. These findings suggest that agents capable of controlling myoplasmic Ca2+ levels may aid in alleviating chronic skeletal muscle dysfunction in patients with burns.
authors.affiliation: Anesthesia Services, Shriners Burns Institute, Boston, MA 02114.
authors.forename: J F
authors.initials: JF
authors.lastname: Tomera
authors.forename: K D
authors.initials: KD
authors.lastname: Friend
authors.forename: S P
authors.initials: SP
authors.lastname: Kukulka
authors.forename: K
authors.initials: K
authors.lastname: Lilford
mesh_terms: D000818:Animals; D001830:Body Surface Area; D002056:Burns / Q000378:metabolism* / Q000503:physiopathology; D002118:Calcium / Q000378:metabolism*; D002454:Cell Differentiation; D051379:Mice; D009132:Muscles / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D002118:Calcium