title: Adult heart transplantation: adverse role of chronic alcoholism in donors on early graft function.
abstract: Because of the increasing shortage of heart donors, selection criteria have been gradually extended. The purpose of this study was to determine the donor-related factors implied in early graft dysfunction and to define new selection criteria. The 70 consecutive adult patients who underwent heart transplantation in our institution between January 1988 and February 1992 were retrospectively studied. Mean donor age was 38 +/- 11 years (10 donors were more than 50 years of age; two donors were more than 60 years of age). Mean ischemic time was 130 +/- 39 minutes. An important proportion of donors (20%) had a history of chronic alcoholism. Thirteen patients experienced immediate graft dysfunction; five of them died within the first operative month. The different parameters studied, which were found to have no significant influence on the early graft function, were the age of the donor, the duration of inotropic support and the dose administered, a relative hemodynamic instability, resuscitation maneuvers, chest trauma, and weight mismatch between donor and recipient. Ischemic time was significantly longer in patients who died of cardiac dysfunction (p < 0.05). Chronic alcoholism in the donor was a very detrimental factor: 54% of patients who had early graft dysfunction versus only 12% of patients who had immediate normal graft function had received a graft from an alcoholic donor (p = 0.003). Excluding such alcoholic donors or reserving them for critically-ill recipients, with an increased risk of early graft dysfunction would be preferable.
authors.affiliation: Marie-Lannelongue Hospital, Paris-Sud University, France.
authors.forename: L
authors.initials: L
authors.lastname: Houyel
authors.forename: J
authors.initials: J
authors.lastname: Petit
authors.forename: R
authors.initials: R
authors.lastname: Nottin
authors.forename: J P
authors.initials: JP
authors.lastname: Duffet
authors.forename: L
authors.initials: L
authors.lastname: Macé
authors.forename: J Y
authors.initials: JY
authors.lastname: Neveux
mesh_terms: D000328:Adult; D000367:Age Factors; D000437:Alcoholism; D006085:Graft Survival / Q000502:physiology*; D016027:Heart Transplantation / Q000401:mortality / Q000502:physiology*; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014019:Tissue Donors