title: Time-dependent effects of oral morphine on autotomy following brachial nerve section in the rat.
abstract: In this study, the effects of morphine in drinking water on autotomy in male F344 rats having undergone brachial nerve sections were assessed during a 3-week period. Morphine was self-administered orally in tap water by the rats. Rats administered morphine just after the nerve section or 1 week after the nerve section showed a significant increase in the severity of autotomy when compared to the rats administered distilled water. Morphine had no effect on autotomy when it was administered 2 weeks after the nerve section. These results suggested that the effect of oral morphine on autotomy changes in a time-dependent manner.
authors.affiliation: Department of Anesthesiology, School of Medicine, Chiba University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Mizuguchi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001917:Brachial Plexus / Q000502:physiology*; D003714:Denervation; D008297:Male; D009020:Morphine / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D011916:Rats, Inbred F344; D012652:Self Mutilation; D013997:Time Factors
chemical_list: D009020:Morphine