title: Case report: treatment of superior sagittal sinus thrombosis with urokinase.
abstract: Sagittal sinus thrombosis (SSST) is a rare disease with high mortality. Definitive therapy is not known, but anticoagulation or addressing the underlying etiology have been the most often utilized approaches. We here report the second case of postpartum sagittal sinus thrombosis successfully treated with urokinase. Though there are no studies to support this therapy it may be safe and efficacious in refractory cases.
authors.affiliation: University of Connecticut School of Medicine.
authors.forename: C A
authors.initials: CA
authors.lastname: Manthous
authors.forename: H
authors.initials: H
authors.lastname: Chen
mesh_terms: D000328:Adult; D002585:Cesarean Section; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D009460:Neurologic Examination / Q000187:drug effects; D011644:Puerperal Disorders / Q000188:drug therapy*; D012851:Sinus Thrombosis, Intracranial / Q000188:drug therapy*; D015912:Thrombolytic Therapy; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D014568:Urokinase-Type Plasminogen Activator