title: Breast cancer--the optimal diet.
abstract: In summary, the evidence based upon global and metabolic epidemiology, and animal studies supported by biologic understanding of the various mechanisms in which dietary fat can affect promotion and progression of breast cancer supports the concept that dietary fat, in particular, certain types of fat, and dietary fiber affect the causation, promotion, and progression of breast cancer. The epidemiologic evidence of the link between breast cancer and dietary fat is still controversial due to methodological problems in designing a valid test. Also a number of studies dealt with the question of fat intake in pre-menopausal women, where admittedly the association is weak. What now needs to be done is to verify the effect of a low-fat diet in post-menopausal breast cancer patients. We suggest that a similar trial on pre-menopausal breast cancer patients in conjunction with ovarian ablation should be conducted. The question to be considered is what in terms of dose, type, and duration of fat and fiber will be required to obtain a measureable effect on the recurrence rate and survival of breast cancer patients.
authors.affiliation: American Health Foundation, Division of Epidemiology, New York, New York.
authors.forename: E L
authors.initials: EL
authors.lastname: Wynder
authors.forename: E
authors.initials: E
authors.lastname: Taioli
authors.forename: D P
authors.initials: DP
authors.lastname: Rose
mesh_terms: D001943:Breast Neoplasms / Q000453:epidemiology / Q000517:prevention & control*; D004041:Dietary Fats / Q000009:adverse effects*; D005260:Female; D006801:Humans; D012307:Risk Factors
chemical_list: D004041:Dietary Fats