The movement of solutes and cells across tight junctions.
The TJ is a highly dynamic rate-limiting barrier for passive transepithelial solute flow. It is not only physiologically regulated but is modulated in various disease states as well. Such modulations occur as a result of epithelial cell interactions with immune cells or immune cell products and thus epithelial barrier function appears to be regulated in disease states.
Madara
J L
JL
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115.
Parkos
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C
Colgan
S
S
Nusrat
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A
Atisook
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K
Kaoutzani
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P
D000038:Abscess / Q000378:metabolism; D000818:Animals; D006801:Humans; D007365:Intercellular Junctions / Q000378:metabolism* / Q000502:physiology; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000648:ultrastructure; D009504:Neutrophils / Q000502:physiology; D010539:Permeability