title: [Chronic calculous cholecystitis: elementary and dysplastic lesions, echographic correlations and immunohistochemical approach].
abstract: The morphological analysis of 223 cases of chronic calculous cholecystitis has drawn attention to the following outstanding facts: (a) elementary lesions are numerous (above all ulceration, mucosal erosion, antral and intestinal metaplasia) and put together a complex sight; (b) mild, moderate and severe dysplasias have a surprising high incidence (67%), even in the age-group under 40; (c) dysplasia is more common in the gallbladders bearing parallel hyperplastic and metaplastic mucosal changes, if compared with gallbladders where these changes are lacking; (d) thickness of gallbladder's wall and incidence of dysplasia are in direct relation; (e) echographic preoperative assessment of wall's thickness has predictive value for presence of dysplasia; (f) CEA and CA 19-9 have a progressively increasing expression in the various degrees of dysplasia.
authors.affiliation: Istituto e museo di anatomia e istologia patologica Università di Pisa.
authors.forename: R
authors.initials: R
authors.lastname: Pingitore
authors.forename: M
authors.initials: M
authors.lastname: Bonucci
authors.forename: D
authors.initials: D
authors.lastname: Bigini
authors.forename: E M
authors.initials: EM
authors.lastname: Ciancia
authors.forename: S
authors.initials: S
authors.lastname: Vignati
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis; D015415:Biomarkers; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002764:Cholecystitis / Q000209:etiology / Q000473:pathology*; D002769:Cholelithiasis / Q000150:complications* / Q000473:pathology; D002908:Chronic Disease; D005260:Female; D005704:Gallbladder / Q000473:pathology*; D005706:Gallbladder Neoplasms / Q000473:pathology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology; D011230:Precancerous Conditions / Q000453:epidemiology / Q000473:pathology*; D011300:Preoperative Care
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D015415:Biomarkers; D002272:Carcinoembryonic Antigen
vernacular_title: La colecistite cronica calcolosa: lesioni elementari e displastiche, correlazioni ecografiche e approccio immunoistochimico.