Behavioural responses to amphetamine and apomorphine in pigs.
The effects of different doses of amphetamine (0-1.5 mg/kg) and apomorphine (0-1.0 mg/kg) on behaviour of pigs were compared. Amphetamine induced an increase in levels of nosing and rooting and of locomotion. These increases were, however, related to increased levels of standing. At higher doses (1.0-1.5 mg/kg), amphetamine specifically induced a rigid standing posture with jerking head and limb movements. Apomorphine at 0.1-1.0 mg/kg increased locomotion. In contrast to amphetamine, this effect was specific as it was not explained by increased levels of standing. At 1.0 mg/kg, apomorphine specifically induced "locomotion while the pigs maintained snout contact with the floor or trough." In addition, at this dose it induced drinking in one test, while licking in another. These differences may in part be due to differences in the test environment. Apomorphine exerted a strong conditioning effect, as indicated by the lack of behavioural variability in the postinjection period. This effect may explain the large interindividual variation in apomorphine response. Amphetamine and apomorphine elicit different behavioural syndromes in pigs, suggesting that they act on different neural systems. In addition, neither amphetamine nor apomorphine elicited behaviour that closely resembles environmentally induced stereotypies.
Terlouw
E M
EM
Scottish Agricultural College, Edinburgh, UK.
De Rosa
G
G
Lawrence
A B
AB
Illius
A W
AW
Ladewig
J
J
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004327:Drinking Behavior / Q000187:drug effects; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009055:Mouth / Q000187:drug effects; D009638:Norepinephrine / Q000097:blood; D011187:Posture; D013239:Stereotyped Behavior / Q000187:drug effects; D013552:Swine
D000661:Amphetamine; D001058:Apomorphine; D006854:Hydrocortisone; D009638:Norepinephrine