Application of triple quadrupole tandem mass spectrometry to the analysis of pyridine-containing derivatives of long-chain acids and alcohols.
An improved derivatization procedure for the preparation of nicotinate and 3-picolinyl esters from mixtures of fatty alcohols and acids has been developed. The derivatives can be analysed by capillary gas chromatography on an SE-54 type column, which affords separation of the acid and alcohol derivatives with the same carbon chain. Detection with tandem mass spectrometric techniques on a triple quadrupole instrument is feasible, and yields informative spectra devoid of coeluting interferences.
Rubino
F M
FM
ITBA-CNR, Milan, Italy.
Zecca
L
L
D002849:Chromatography, Gas; D005227:Fatty Acids / Q000032:analysis*; D005233:Fatty Alcohols / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods*; D011725:Pyridines / Q000032:analysis*
D005227:Fatty Acids; D005233:Fatty Alcohols; D011725:Pyridines; C023666:pyridine