title: Biocompatibility of retrograde filling materials in the ferret canine. Amalgam and IRM.
abstract: Periapical tissue response to retrograde fillings of amalgam and IRM were compared in the mandibular canine of the adult male ferret. Teeth were cleaned and shaped with a standard technique and obturated with gutta-percha. The root apex was then exposed and retrofillings were placed. The animals were grouped according to observation periods of 5, 10, and 15 weeks. At the proper time the animals were killed and the lower canine tooth along with the surrounding bone was removed. The tissue blocks were examined clinically, radiographed, and prepared for histologic examination. The clinical and radiographic examination indicated both materials to be well tolerated by periapical tissues. Microscopic examination of amalgam specimens showed a decrease in inflammation and the formation of a fibrous capsule over the 15-week period. IRM specimens showed persistent inflammation and slower healing potential.
authors.affiliation: Department of Endodontics, University of Detroit Mercy, School of Dentistry, Mich.
authors.forename: W P
authors.initials: WP
authors.lastname: Maher
authors.forename: R L
authors.initials: RL
authors.lastname: Johnson
authors.forename: J
authors.initials: J
authors.lastname: Hess
authors.forename: H R
authors.initials: HR
authors.lastname: Steiman
mesh_terms: D000539:Alveolar Process / Q000473:pathology; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D003094:Collagen; D003238:Connective Tissue / Q000473:pathology; D003723:Dental Amalgam / Q000737:chemistry*; D005289:Ferrets; D005337:Fibrin; D005549:Foreign-Body Reaction / Q000473:pathology; D015726:Giant Cells / Q000473:pathology; D006171:Gutta-Percha / Q000737:chemistry; D007249:Inflammation; D008297:Male; D008768:Methylmethacrylates / Q000737:chemistry*; D010012:Osteogenesis; D010486:Periapical Tissue / Q000473:pathology; D012184:Retrograde Obturation; D012387:Root Canal Filling Materials / Q000737:chemistry*; D012390:Root Canal Therapy; D014945:Wound Healing; D015035:Zinc Oxide-Eugenol Cement / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D008768:Methylmethacrylates; D012387:Root Canal Filling Materials; D015035:Zinc Oxide-Eugenol Cement; C031667:IRM cement; D003723:Dental Amalgam; D006171:Gutta-Percha; D005337:Fibrin; D003094:Collagen