[The dual regulation by glucagon of the adenylate cyclase system in the embryonic chick heart].
Taken in physiological concentrations, glucagon increases the activity of adenylate cyclase from the heart of 11-day chick embryos, i.e. at the earliest investigated stage. High glucagon concentrations inhibit the enzyme from cardiac membranes at all ontogenetic stages except mature chicks in which glucagon produces stimulating effect. Guanine nucleotides potentiate this effect up to the 16th day of incubation, this effect being absent at later periods. Reconstruction of adenylate cyclase system from the heart of 16-day embryos with N-proteins from mature liver tissue of chicks results in the recovery of potentiating effect. However, at later developmental stages, potentiation was absent even in the presence of N-proteins.
Derkach
K V
KV
Kuznetsova
L A
LA
Plesneva
S A
SA
D000262:Adenylyl Cyclases / Q000187:drug effects / Q000494:pharmacology*; D000818:Animals; D002642:Chick Embryo; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D019204:GTP-Binding Proteins / Q000187:drug effects / Q000302:isolation & purification / Q000502:physiology; D005934:Glucagon / Q000187:drug effects / Q000494:pharmacology / Q000502:physiology*; D006150:Guanine Nucleotides / Q000494:pharmacology; D006321:Heart / Q000187:drug effects / Q000196:embryology*; D008099:Liver / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology*; D013997:Time Factors
D006150:Guanine Nucleotides; D005934:Glucagon; D019204:GTP-Binding Proteins; D000262:Adenylyl Cyclases
Dvoĭstvennaia reguliatsiia gliukagonom adenilattsiklaznoĭ sistemy émbrional'nogo serdtsa kur.