Effect of medroxyprogesterone acetate on immunohistochemical expression of estradiol in endometrial carcinoma.
The effect of medroxyprogesterone acetate (MPA) on the immunohistochemical expression of estradiol (E2) was investigated in 25 cases of endometrial carcinoma. Twenty-three cases of the endometrial carcinomas showed positive immunoreactivity for E2. The immunohistochemical expression of E2 was more intensive in carcinoma cells than in stromal cells. Although the morphologic alterations induced by MPA treatment were observed only in 2 cases who were administered more than 30,000 mg of MPA, the staining intensity in most cases appeared to decrease after the treatment. The decrease in E2 immunoreactivities of cancer cells as well as of stromal cells in Grade 1 or Grade 2 was significant. These results suggest that MPA might decrease the E2 content in endometrial carcinoma cells as well as in stromal cells.
Yokoyama
Y
Y
Department of Obstetrics and Gynecology, Gifu University School of Medicine, Japan.
Sumi
H
H
Tamaya
T
T
D016889:Endometrial Neoplasms / Q000737:chemistry* / Q000473:pathology; D004958:Estradiol / Q000032:analysis*; D005260:Female; D006801:Humans; D007399:Interphase; D017258:Medroxyprogesterone Acetate / Q000494:pharmacology*
D004958:Estradiol; D017258:Medroxyprogesterone Acetate