title: [Immunopathologic study of the myocardium in dilated cardiomyopathy].
abstract: Myocardial tissues of patients with dilated cardiomyopathy were studied by immunofluorescence. While immunoglobulin A fixation was observed in myocardial capillary wall and cardiomyocyte sarcolemma in the majority of patients (11 of 12), immunoglobulin G and C3 complement component were a rare finding. In the vessel wall of heart allografts immunoglobulin A fixation occurred 3-6 days after transplantation. As a result of the intensive immunosuppressive therapy which was used after the operation immunoglobulin A disappeared from heart allografts within 4-5 weeks. Immunoglobulin A fixation in the heart of patients with dilated cardiomyopathy is attributed to the anti-tissue or antivirus antibodies and probably is involved in the development of this disease.
authors.forename: L V
authors.initials: LV
authors.lastname: Beletskaia
authors.forename: F S
authors.initials: FS
authors.lastname: Baranova
authors.forename: G M
authors.initials: GM
authors.lastname: Mogilevskiĭ
authors.forename: L G
authors.initials: LG
authors.lastname: Kurenkova
authors.forename: E N
authors.initials: EN
authors.lastname: Kazakov
authors.forename: A Ia
authors.initials: AIa
authors.lastname: Kormer
authors.forename: I V
authors.initials: IV
authors.lastname: Smirnova
authors.forename: Z A
authors.initials: ZA
authors.lastname: Khalimova
authors.forename: A A
authors.initials: AA
authors.lastname: Dmitriev
authors.forename: V V
authors.initials: VV
authors.lastname: Chestukhin
mesh_terms: D001706:Biopsy; D002311:Cardiomyopathy, Dilated / Q000276:immunology / Q000473:pathology*; D003176:Complement C3 / Q000032:analysis; D005455:Fluorescent Antibody Technique; D016027:Heart Transplantation / Q000473:pathology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D014184:Transplantation, Homologous
chemical_list: D003176:Complement C3; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents
vernacular_title: Immunopatologicheskoe issledovanie miokarda pri diliatatsionnoĭ kardiomiopatii.