title: [Successful local adoptive immunotherapy for pleuritis carcinomatosa due to renal cell cancer. A case report].
abstract: A 54-year-old woman who had undergone radical nephrectomy for renal cell cancer nine months before was admitted to our hospital because of difficulty in breathing. X-ray films of the chest showed massive pleural effusion on the left side and cytological examination of the effusion revealed malignant cells which may have originated from renal cell cancer. Intrapleural instillations of interleukin-2 and of tumor infiltrating lymphocytes isolated from the pleural effusion were performed. After the initiation of the treatment, the pleural effusion decreased and malignant cells disappeared from the pleural fluid. Partial response defined by the criteria provided by the Japan Lung Cancer Society was achieved. No serious side effects were observed. This would be a useful treatment for pleuritis carcinomatosa by renal cell cancer.
authors.affiliation: Department of Urology, Niigata University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Saito
authors.forename: M
authors.initials: M
authors.lastname: Terunuma
authors.forename: T
authors.initials: T
authors.lastname: Koizumi
authors.forename: T
authors.initials: T
authors.lastname: Nishiyama
authors.forename: H
authors.initials: H
authors.lastname: Gou
authors.forename: Y
authors.initials: Y
authors.lastname: Tomita
mesh_terms: D002292:Carcinoma, Renal Cell / Q000150:complications*; D005260:Female; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods; D007322:Instillation, Drug; D007376:Interleukin-2 / Q000008:administration & dosage / Q000627:therapeutic use; D007680:Kidney Neoplasms / Q000150:complications*; D016246:Lymphocytes, Tumor-Infiltrating / Q000637:transplantation; D008875:Middle Aged; D010994:Pleura; D016066:Pleural Effusion, Malignant / Q000209:etiology / Q000628:therapy*; D010998:Pleurisy / Q000209:etiology / Q000628:therapy*
chemical_list: D007376:Interleukin-2