[The possible participation of the GABA metabolic system in the mechanisms of the protective action of L-aspartate in hypoxia in an enclosed space].
L-Aspartate given intradermally in a dose of 100 mg.kg-1 to mice 2-3 minutes before placement to a hypoxic chamber was shown to prolong the mean animal lifespan by 38% and to delay hypoxic convulsions by 38-40%. The agent was ascertained to maintain the higher glutamate decarboxylase (GD) activity and GABA levels in the brain during hypoxia and prevent GD activity and GABA levels from their drastic diminution when hypoxic convulsions occurred.
Abu-Asali
I I
II
Reĭtarova
T E
TE
Rozanov
V A
VA
Rozanov
A Ia
AIa
D000208:Acute Disease; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D001224:Aspartic Acid / Q000627:therapeutic use*; D001923:Brain Chemistry / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004780:Environment, Controlled; D000860:Hypoxia / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism / Q000401:mortality; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012640:Seizures / Q000209:etiology / Q000517:prevention & control; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D000927:Anticonvulsants; D001224:Aspartic Acid; D005680:gamma-Aminobutyric Acid
O vozmozhnom uchastii sistemy metabolizma GAMK v mekhanizmakh zashchitnogo deĭstviia L-aspartata pri gipoksii zamknutogo prostranstva.