title: Synaptophysin expression in "ependymal tumors" induced by ethyl-nitrosourea in rats.
abstract: Synaptophysin expression was studied in seven "ependymomas" induced by transplacental administration of ethyl-nitrosourea in rats. In all the cases, strong positivity for synaptophysin was found on tumor cells. This finding supports previous studies suggesting that ENU-induced brain tumors considered to be ependymal neoplasms, are, in fact, primitive neuroectodermal tumors.
authors.affiliation: Neurosurgical Department, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Vaquero
authors.forename: S
authors.initials: S
authors.lastname: Coca
authors.forename: M
authors.initials: M
authors.lastname: Zurita
authors.forename: S
authors.initials: S
authors.lastname: Oya
authors.forename: A
authors.initials: A
authors.lastname: Arias
authors.forename: M
authors.initials: M
authors.lastname: Moreno
authors.forename: C
authors.initials: C
authors.lastname: Morales
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000139:chemically induced* / Q000737:chemistry*; D004805:Ependyma / Q000737:chemistry / Q000473:pathology; D004806:Ependymoma / Q000139:chemically induced* / Q000737:chemistry*; D005038:Ethylnitrosourea; D005260:Female; D007150:Immunohistochemistry; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D016708:Synaptophysin / Q000032:analysis*
chemical_list: D016708:Synaptophysin; D005038:Ethylnitrosourea