LDL receptor-dependent polyunsaturated fatty acid transport and metabolism.
It is widely assumed that eicosanoid biosynthesis is initiated by an increase in the intracellular concentration of unesterified arachidonic acid (AA) as a consequence of the activation of cellular phospholipases and/or inhibition of AA reacylation reactions. Here, we describe a mechanism of eicosanoid formation that is entirely dependent on low density lipoprotein (LDL) receptor-mediated delivery of AA to eicosanoid producing target cells. This LDL AA pathway introduces a new regulatory component into the provision of unsaturated fatty acids to mammalian cells.
Habenicht
A J
AJ
University of Heidelberg, Medical School, Department of Medicine, FRG.
Salbach
P
P
Janssen-Timmen
U
U
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D001692:Biological Transport; D004705:Endocytosis / Q000187:drug effects; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008077:Lipoproteins, LDL / Q000494:pharmacology; D009000:Monocytes / Q000378:metabolism; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology; D011453:Prostaglandins / Q000096:biosynthesis; D011973:Receptors, LDL / Q000502:physiology
D005231:Fatty Acids, Unsaturated; D008077:Lipoproteins, LDL; D010982:Platelet-Derived Growth Factor; D011453:Prostaglandins; D011973:Receptors, LDL; D016718:Arachidonic Acid