Prediction of susceptibility to rheumatoid arthritis by human leukocyte antigen genotyping.
Recent methodologic advances now allow the precise identification of HLA genes in individuals. Population studies using these methods have pinpointed the HLA alleles strongly associated with rheumatoid arthritis (RA). This article summarizes the current status of these RA-associated HLA genes in disease susceptibility and uses that information to derive estimates of risk ratios for prediction of disease in an individual.
Nepom
G T
GT
Immunology Program, Virginia Mason Research Center, Seattle, Washington.
Nepom
B S
BS
D001172:Arthritis, Rheumatoid / Q000235:genetics*; D005544:Forecasting; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D016017:Odds Ratio
D006680:HLA Antigens