[Clinical significance of serum CA130 level in women with spontaneous abortion, hydatidiform mole and early normal and tubal pregnancy].
We examined the serum CA130 level in women in early pregnancy with normal (n = 13), and abnormal (n = 28) course. The abnormal course consisted of intrauterine spontaneous abortion (n = 10), hydatidiform mole (n = 3) and tubal pregnancy (n = 15). The serum CA130 level was higher than for normal nonpregnant women (35u/ml) in 69% (9/13) of women with normal pregnancy, 90% (9/10) of those with intrauterine spontaneous abortion and 100% (3/3) of those with hydatidiform mole; the mean value and standard deviation for these three groups were 131 +/- 150u/ml (n = 13), 197 +/- 253u/ml (n = 10), and 47 +/- 15u/ml (n = 3), respectively. In contrast, the serum CA130 level of the 15 women with tubal pregnancy was 28 +/- 21u/ml. Among these patients, all of the 13 women without genital bleeding had a CA130 level within the normal range for nonpregnant women (mean +/- SD; 20 +/- 6u/ml). Since CA130 is abundant in the decidual tissue but is scant in tubal tissue, a high CA130 level in maternal sera during early pregnancy may indicate the presence of the destruction of decidual tissue, while a low or normal CA130 level throughout early pregnancy is regarded as characteristic of tubal pregnancy.
Kobayashi
F
F
Department of Obstetrics and Gynecology, Kobe Central Municipal Hospital.
Park
K R
KR
Yamashita
M
M
Nonogaki
M
M
Hoshino
T
T
Shimada
H
H
Ono
Y
Y
Ikeuchi
M
M
Takashima
E
E
Sagawa
N
N
D000022:Abortion, Spontaneous / Q000175:diagnosis*; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D003656:Decidua / Q000503:physiopathology; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000175:diagnosis*; D011247:Pregnancy; D011274:Pregnancy, Tubal / Q000175:diagnosis*; D014594:Uterine Neoplasms / Q000175:diagnosis*
D015295:Antigens, Tumor-Associated, Carbohydrate; D015415:Biomarkers