title: The amino acid sequence of a mammalian MAP kinase kinase.
abstract: The amino acid sequence of the dual specificity mitogen-activated protein kinase kinase (MAPKK) has been determined by cDNA cloning and amino acid sequencing. MAPKK (393 residues, Mr 43,330) is a new member of the protein kinase subclass that comprises byr1 and STE7 that are involved in pheromone dependent signal transduction in yeast, wis1 a mitotic regulator in S. pombe and PBS2, which confers antibiotic resistance in S. cerevisiae.
authors.affiliation: Chester Beatty Laboratories, Institute of Cancer Research London.
authors.forename: A
authors.initials: A
authors.lastname: Ashworth
authors.forename: S
authors.initials: S
authors.lastname: Nakielny
authors.forename: P
authors.initials: P
authors.lastname: Cohen
authors.forename: C
authors.initials: C
authors.lastname: Marshall
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D020929:Mitogen-Activated Protein Kinase Kinases; D008969:Molecular Sequence Data; D011494:Protein Kinases / Q000737:chemistry / Q000235:genetics*; D011817:Rabbits; D012441:Saccharomyces cerevisiae / Q000502:physiology; D012568:Schizosaccharomyces / Q000502:physiology; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction
chemical_list: D011494:Protein Kinases; D020929:Mitogen-Activated Protein Kinase Kinases