title: 13C and 1H NMR study of the metabolic degradation of 4-pentenoate in different dog nephron segments.
abstract: The metabolism of 4-pentenoate in isolated kidney tubules has been investigated by 1H and 13C NMR. The 4-pentenoate metabolite, 3-keto-4-pentenoyl-CoA, accumulated in proximal tubules only and its formation could be competitively inhibited by octanoate. 4-Pentenoate was metabolized in thick ascending limbs but not in papillary collecting ducts.
authors.affiliation: Département de Physiologie, Université de Montréal, Quebec, Canada.
authors.forename: Y
authors.initials: Y
authors.lastname: Boulanger
authors.forename: H
authors.initials: H
authors.lastname: Wong
authors.forename: A
authors.initials: A
authors.lastname: Fleser
authors.forename: F
authors.initials: F
authors.lastname: Commodari
authors.forename: P
authors.initials: P
authors.lastname: Vinay
mesh_terms: D000818:Animals; D002210:Caprylates / Q000494:pharmacology; D004285:Dogs; D005229:Fatty Acids, Monounsaturated / Q000378:metabolism*; D007684:Kidney Tubules / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy
chemical_list: D002210:Caprylates; D005229:Fatty Acids, Monounsaturated; C009785:4-pentenoic acid; C031492:octanoic acid