title: [Kleine-Levin syndrome].
abstract: The Kleine-Levin syndrome is a rare and probably underdiagnosed syndrome. It is characterized by periodic attacks of the triad: hypersomnia, vegative disturbances such as hyperphagia and hypersexuality, psychopathological changes in the level of consciousness and control of emotions. Boys and young men in the age group 10-20 years are most commonly affected. Spontaneous remission with a tendency to remission is observed and the disease "burns out" after a prolonged period of years. The etiology and pathogenesis are unknown. Theories have been propounded suggesting dysfunction of the hypothalamus. No pathognomonic findings have been observed in the early phase of sleep during the daylight hours. Central stimulating drugs have been reported to have some effect on the hypersomnia. The diagnosis is based on the clinical picture. Frequently, a long period can elapse before the diagnosis is established and some cases are never diagnosed. The literature is reviewed and is illustrated by two case reports.
authors.affiliation: Psykiatrisk Børnehospital, Risskov.
authors.forename: D
authors.initials: D
authors.lastname: Hansen
authors.forename: L
authors.initials: L
authors.lastname: Lønborg-Møller
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003937:Diagnosis, Differential; D006970:Disorders of Excessive Somnolence / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D006801:Humans; D006963:Hyperphagia / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D011379:Prognosis; D013577:Syndrome
vernacular_title: Kleine-Levin's syndrom.