Biologically active complexes of nickel(II), copper(II) and zinc(II) with Schiff-base ligand derived from the reaction of 2-aminopyridine and pyrrol-2-carboxaldehyde--their synthesis and characterisation.
A new Schiff-base ligand N-(2'-pyrrylmethylidene)2-aminopyrimidine derived from the reaction of 2-amino pyrimidine and pyrrol-2-carboxaldehyde and its nickel(II), copper(II) and zinc(II) complexes have been synthesised and characterised on the basis of elemental analysis, molar conductance, infrared, electronic and proton nuclear magnetic resonance (1H-NMR) and magnetic susceptibility data. The ligand and its complexes when screened for antibacterial activity against bacterial species such as, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae. In all cases, the activity substantially increased on complexation with metals.
Chohan
Z H
ZH
Department of Chemistry, Islamia University, Bahawalpur, Pakistan.
Kausar
S
S
D000631:Aminopyridines / Q000737:chemistry* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D007097:Imines / Q000138:chemical synthesis* / Q000494:pharmacology; D008024:Ligands; D008670:Metals / Q000737:chemistry* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D011758:Pyrroles / Q000737:chemistry* / Q000494:pharmacology; D012545:Schiff Bases
D000631:Aminopyridines; D000900:Anti-Bacterial Agents; D007097:Imines; D008024:Ligands; D008670:Metals; D011743:Pyrimidines; D011758:Pyrroles; D012545:Schiff Bases; C051266:pyrrole-2-carboxaldehyde; C078305:N-(2'-pyrrylmethylidene)-2-aminopyrimidine; C032439:alpha-aminopyridine