A study on Lu-null families in South Wales.
Red cells of 75614 blood donors in South Wales were screened with anti-Lu(b) revealing 54 Lu(b-) donors of which 15 were also Lu(a-) giving a frequency of 0.0002 for the Lu(a-b-) phenotype in South Wales. The families of 11 Lu-null propositi were investigated to determine which of the three known genetic backgrounds, dominant, recessive or X-linked recessive, was responsible for their Lu-null phenotype. In 10 of the 11 families the Lu-null phenotype was caused by the dominant suppressor gene In(Lu). The first reported family demonstrating independence of In(Lu) and LU, through the Au groups, is described together with the third family demonstrating suppression of P1 by In(Lu). The families showed that In(Lu) is not closely linked to HLA. The genetic background for the 11th propositus was not determined; homozygosity of the silent allele LU is a possible but unproved explanation.
Rowe
G P
GP
Welsh Regional Transfusion Centre, Cardiff, Wales.
Gale
S A
SA
Daniels
G L
GL
Green
C A
CA
Tippett
P
P
D005260:Female; D006801:Humans; D008126:Lod Score; D008188:Lutheran Blood-Group System / Q000235:genetics*; D008297:Male; D010375:Pedigree; D010641:Phenotype; D014852:Wales
D008188:Lutheran Blood-Group System