[Role of endothelin in the pathogenesis of rat experimental hypertension produced by aorta narrowing and saline uptake].
Endothelin is a bioactive polypeptide released from vascular endothelium, which has a strong action promoting vascular contraction, proliferation and hypertrophy of vascular smooth muscle cells. The present investigation was performed on the hypertensive rat produced by narrowing abdominal aorta and drinking saline. It was observed that the level of plasma endothelin in the hypertensive rats was doubled (9.70 +/- 0.68 vs. sham group 4.11 +/- 0.33 pg/ml, P < 0.01), and administration of specific endothelin-antiserum into hypertensive rats significantly attenuated the increase in the blood pressure (18.97 + 1.32 vs. 27.33 + 0.09 kPa in untreated hypertensive rats, P < 0.01), and dramatically ameliorated malfunction resulting from myocardial hypertrophy. The results suggest that endothelin is an important factor in the pathogenesis of hypertension, and that inhibition of endothelin action may be a new effective way in prevention and therapy of hypertension.
Zhang
L Y
LY
Laboratory of Cardiopulmonary Endocrinology, Beijing Medical University.
Dong
S Y
SY
Tang
J
J
Tang
C S
CS
D000818:Animals; D001012:Aorta, Abdominal; D001794:Blood Pressure; D003250:Constriction; D016232:Endothelins / Q000502:physiology*; D006973:Hypertension / Q000097:blood / Q000209:etiology*; D007106:Immune Sera; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000008:administration & dosage
D016232:Endothelins; D007106:Immune Sera; D012964:Sodium