[Effect of nitrobenzoic acid on methemoglobin content in blood and activity of antioxidative enzymes in erythrocytes].
Intraperitoneal administration of meta-nitrobenzoic, 3,5-dinitrobenzoic, 2,4,6-trinitrobenzoic and 3,5-dinitro-4-methylbenzoic acids to the white mice in a dose equal to LD50 has induced an increase in the methaemoglobin content in their blood. Total activity of dehydrogenases of pentosephosphate pathway, content of 2,3-diphosphoglycerate increase in response to the intoxication evoked by the mentioned acids. The acute intoxication does not practically change the activity of the key enzymes of antioxidant protection: superoxide-dismutase, catalase and glutathione peroxidase.
Shugaleĭ
I V
IV
Tselinskiĭ
I V
IV
Dolmatov
V Iu
VIu
D019794:2,3-Diphosphoglycerate; D000818:Animals; D002374:Catalase / Q000097:blood / Q000187:drug effects*; D004163:Diphosphoglyceric Acids / Q000097:blood; D004912:Erythrocytes / Q000187:drug effects* / Q000201:enzymology; D005979:Glutathione Peroxidase / Q000097:blood / Q000187:drug effects*; D008706:Methemoglobin / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D009579:Nitrobenzoates / Q000494:pharmacology*; D010427:Pentose Phosphate Pathway / Q000187:drug effects; D013482:Superoxide Dismutase / Q000097:blood / Q000187:drug effects*
D004163:Diphosphoglyceric Acids; D009579:Nitrobenzoates; D019794:2,3-Diphosphoglycerate; D008706:Methemoglobin; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase
Vliianie nitrobenzoĭnykh kislot na soderzhanie metgemoglobina v krovi i aktivnost' antiokislitel'nykh fermentov éritrotsitov.