[Models of experimental Haemophilus influenzae and Streptococcus pneumoniae pneumonia in mice].
Streptococcus pneumoniae and Haemophilus influenzae are the bacteria most frequently involved in bronchopulmonary and E.N.T. diseases. Experimental models are useful to analyse in vivo the physiopathological interactions between bacteria and lung tissue and to study the activity of various antibiotics in the focus of infection. Models for pneumococci are devised according to the virulence of the strain, the inoculation technique and the type of animal used. When strains of different virulence and hosts of different lineage are combined, several experimental models with different natural histories are obtained. These experimental models make it possible to study therapeutic measures at different stages, comparing the relative activities of fluoroquinolones, ampicillin and macrolides. For fluoroquinolones, no correlation has been found between in vivo and in vitro data in these models, but the effectiveness of new compounds has been studied. As regard Haemophilus influenzae, lung infection models are rare, either because their septicaemic component is too important or because they do not enable this organism to multiply. Moreover, the models obtained do not lend themselves easily to therapeutic trials and favour those antibiotics that have high serum concentrations. Developing a better model would enable us to improve our knowledge of the pathogenicity of this micro-organism.
Bédos
J P
JP
Clinique de Réanimation des Maladies Infectieuses, Hôpital Bichat-Claude Bernard, Paris.
Vallée
E
E
D000667:Ampicillin / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use; D024841:Fluoroquinolones; D006192:Haemophilus Infections / Q000188:drug therapy / Q000503:physiopathology*; D006193:Haemophilus influenzae / Q000472:pathogenicity*; D018942:Macrolides; D051379:Mice; D008810:Mice, Inbred C57BL; D008826:Microbial Sensitivity Tests; D008954:Models, Biological; D011018:Pneumonia, Pneumococcal / Q000188:drug therapy / Q000503:physiopathology*; D013296:Streptococcus pneumoniae / Q000472:pathogenicity*; D014774:Virulence
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D018942:Macrolides; D000667:Ampicillin
Modèles de pneumopathies expérimentales chez la souris à Haemophilus influenzae et Streptococcus pneumoniae.