Regional effects of neurotensin on the electrically stimulated release of [3H]dopamine and [14C]acetylcholine in the rat nucleus accumbens.
This study has shown that neurotensin (NT) increases the electrically stimulated release of [3H]DA to a similar extent in all but the extreme caudolateral area of the rat nucleus accumbens and appears to modulate DA release equally in the medial and lateral zones of this brain area. The simultaneous release of ACh was not significantly affected by NT.
Reyneke
L
L
Department of Chemical Pathology, University of Stellenbosch, Tygerberg Hospital, South Africa.
Russell
V A
VA
Taljaard
J J
JJ
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D002250:Carbon Radioisotopes; D004298:Dopamine / Q000378:metabolism*; D004558:Electric Stimulation; D008297:Male; D009496:Neurotensin / Q000494:pharmacology*; D009714:Nucleus Accumbens / Q000187:drug effects* / Q000378:metabolism; D010477:Perfusion; D051381:Rats; D017208:Rats, Wistar; D014316:Tritium
D002250:Carbon Radioisotopes; D014316:Tritium; D009496:Neurotensin; D000109:Acetylcholine; D004298:Dopamine