Immunohistological study of distribution of gamma/delta lymphocytes after allogeneic bone marrow transplantation.
The distribution of T lymphocytes expressing the gamma/delta form of the T cell receptor was studied in the liver, intestine, and major lymphoid organs, after bone marrow transplantation (BMT), including cases of graft versus host disease (GvHD). The number of gamma/delta as a proportion of the total number of CD3 positive cells did not differ from that found in normal tissues; the higher percentage normally found in the intestinal epithelium and splenic red pulp was maintained. This, and the results of a previous study undertaken on the skin, provide no evidence that gamma/delta T cells have a particularly important role in T cell regeneration after marrow transplantation or in the pathogenesis of the epithelial lesions associated with GvHD.
Norton
J
J
Department of Histopathology, Royal Marsden Hospital, Sutton, Surrey.
al-Saffar
N
N
Sloane
J P
JP
D000328:Adult; D016026:Bone Marrow Transplantation / Q000276:immunology*; D017252:CD3 Complex / Q000032:analysis; D006086:Graft vs Host Disease / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D017252:CD3 Complex; D016692:Receptors, Antigen, T-Cell, gamma-delta