Protective effect of NGF atelocollagen mini-pellet on the hippocampal delayed neuronal death in gerbils.
Very recently, contradictory results were presented as to the effects of exogenous nerve growth factor (NGF) on the hippocampal delayed neuronal necrosis following transient ischemia. In the present study, we administered a large amount of NGF with the atelocollagen mini-pellet system, measured the local NGF contents, and evaluated the effect of this neurotrophic factor on the postischemic hippocampal pyramidal cells in gerbils. We concluded that the exogenous NGF, when given continuously at sufficient concentrations, prevents pyramidal cell damage. The possible cause of discrepancy in previous studies is discussed.
Yamamoto
S
S
Department of Neurosurgery, Osaka University Medical School, Japan.
Yoshimine
T
T
Fujita
T
T
Kuroda
R
R
Irie
T
T
Fujioka
K
K
Hayakawa
T
T
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers; D004343:Drug Implants; D005260:Female; D005849:Gerbillinae; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects*; D009414:Nerve Growth Factors / Q000008:administration & dosage* / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
D004337:Drug Carriers; D004343:Drug Implants; D009414:Nerve Growth Factors