title: Growth and functional assessment of pulmonary valves in pigs after replacement of sinuses of Valsalva.
abstract: Neopulmonary artery stenosis may occur after the arterial switching procedure to correct transposition of the great arteries. One technique to reduce this complication is to use a single rectangular piece of autogenous pericardium to reconstruct two adjacent sinuses of Valsalva and maintain pulmonary artery size. The long-term effect of this technique on pulmonary artery and valve growth and function is unknown. To assess this technique, Yorkshire-cross pigs (n = 5) weighing 29 +/- 1.7 kg (mean +/- SEM) were anesthetized, and during cardiopulmonary bypass, the pulmonary artery was transected distal to the pulmonary valve. Pulmonary artery diameter and commissure distances were measured. Two adjacent pulmonary artery sinuses of Valsalva were completely excised from the anulus to 4 mm distal to the commissures, leaving 2 mm of pulmonary artery tissue attached to the skeletonized commissure and on each side of the one remaining intact sinus of Valsalva. A single rectangular patch of fresh autologous pericardium was sutured to the anulus and remnant of the pulmonary artery along the commissure and edges of the one intact sinus of Valsalva. Pericardium composed two thirds of the circumference of the proximal pulmonary artery; this was anastomosed to the distal pulmonary artery. Weight gain occurred at a rate of 0.6 kg/day (median). The animals underwent right heart catheterization and cineangiography. They were killed 157.2 +/- 12.9 days post-operatively. The reconstructed pulmonary artery grew from 17.6 +/- 0.8 mm to 30.8 +/- 1.5 mm (p < 0.01), and the commissure distances grew from 17.0 +/- 1 mm to 27.2 +/- 1.6 mm (p < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Division of Cardiothoracic Surgery, University of Missouri-Columbia 65212.
authors.forename: J T
authors.initials: JT
authors.lastname: Walls
authors.forename: W C
authors.initials: WC
authors.lastname: McDaniel
authors.forename: E R
authors.initials: ER
authors.lastname: Pope
authors.forename: J A
authors.initials: JA
authors.lastname: Smith
authors.forename: R E
authors.initials: RE
authors.lastname: Fish
authors.forename: G C
authors.initials: GC
authors.lastname: Flaker
authors.forename: J J
authors.initials: JJ
authors.lastname: Curtis
authors.forename: J R
authors.initials: JR
authors.lastname: Turk
authors.forename: C C
authors.initials: CC
authors.lastname: Wagner-Mann
mesh_terms: D000818:Animals; D005069:Evaluation Studies as Topic; D010496:Pericardium / Q000637:transplantation; D011183:Postoperative Complications / Q000209:etiology; D011651:Pulmonary Artery / Q000254:growth & development / Q000502:physiology; D011664:Pulmonary Valve / Q000254:growth & development* / Q000502:physiology; D011666:Pulmonary Valve Stenosis / Q000209:etiology / Q000517:prevention & control; D012850:Sinus of Valsalva / Q000601:surgery*; D013552:Swine; D014182:Transplantation, Autologous