Variant complex translocation t(8;15;21) in acute myeloblastic leukemia (M2) associated with bilateral chloroma.
Complex translocation t(8;15;21)(q22;q21;q22) in a 9-year-old female with acute myeloblastic leukemia (M2) with bilateral chloroma is described. This particular variant type of translocation in M2 type is rare. The importance of variant translocation in defining the critical segment on the chromosomes responsible for phenotypic expression of the disease is emphasized.
Sundareshan
T S
TS
Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, India.
Augustus
M
M
Yasha
T C
TC
Shailaja
S N
SN
Lalitha
N
N
D002648:Child; D002884:Chromosomes, Human, Pair 15; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D008207:Lymphatic Metastasis; D009378:Neoplasms, Multiple Primary / Q000235:genetics; D009918:Orbital Neoplasms / Q000235:genetics; D014178:Translocation, Genetic