Immunohistochemical and ultrastructural investigation of new membrane-associated placental tissue proteins (MP2 A, B, C, D, and E) in gynecologic neoplasms.
New membrane-associated placental tissue proteins (MP2 A, B, C, D, and E) were investigated immunohistochemically by avidin-biotin immunoperoxidase technique and immunoelectron microscopy in various gynecologic neoplasms and normal gynecologic tissues. MP2 A and MP2 B were not specific for malignant tumors. MP2 C was present in 67-100% of ovarian carcinomas, 100% of benign dermoid cysts, and 77% of endometrial carcinomas. Except for endocervical adenocarcinomas, MP2 D was hardly detectable in gynecologic malignancies. Although MP2 E was hardly detectable in benign gynecologic tumors, this protein was present in ovarian carcinomas, uterine squamous carcinomas, endocervical adenocarcinomas, and endometrial adenocarcinomas. These results suggest a possible clinical application of these MP2 proteins as a new tumor marker for gynecologic malignancies.
Hirai
Y
Y
Department of Gynecology, Cancer Institute Hospital, Tokyo, Japan.
Inaba
N
N
Takamizawa
H
H
Chen
J T
JT
Hasumi
K
K
Masubuchi
K
K
Bohn
H
H
Suemizu
H
H
Osamura
Y
Y
Watanabe
K
K
D014408:Biomarkers, Tumor / Q000378:metabolism*; D002584:Cervix Uteri / Q000378:metabolism; D004717:Endometrium / Q000378:metabolism; D005260:Female; D005833:Genital Neoplasms, Female / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008565:Membrane Proteins / Q000378:metabolism*; D009215:Myometrium / Q000378:metabolism; D010053:Ovary / Q000378:metabolism; D011257:Pregnancy Proteins / Q000378:metabolism*
D014408:Biomarkers, Tumor; D008565:Membrane Proteins; D011257:Pregnancy Proteins