[Function, molecular structure and gene expression regulation of interleukin 9 (IL-9)].
Interleukin-9 (IL-9)/P40 is a recently reported murine growth factor for helper T-cell clones. It is produced by ConA stimulated CD4+ T-cells or several T-cell lines such as TUC 2.15 derived from C57Bl/6 mouse. In the murine system, IL-9/P40 directly supported proliferation of mucosal type mast cells, and also induced erythroid burst formation, indirectly. On the other hand, human IL-9, which is a homologue to murine P40, was cloned from a cDNA library prepared with mRNA isolated from PHA-induced T-cell line (C5MJ2). Analysis of the sequence of cDNA revealed a striking similarity between murine and human IL-9/P40. Human IL-9 supported formation of a subpopulation of erythroid bursts that are responsive to IL-3. In this communication, identification, cloning of cDNA, and biological activities of murine and human IL-9/P40 are discussed.
Sonoda
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Department of Hygiene, Kyoto Prefectural University of Medicine.
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D003001:Cloning, Molecular; D015672:Erythroid Precursor Cells / Q000166:cytology; D016906:Interleukin-9 / Q000235:genetics / Q000502:physiology*; D051379:Mice
D016906:Interleukin-9