title: [The efficacy of nitrendipine in patients with stable arterial hypertension. The data from a cooperative study in the USSR. The Working Group for the Cooperative Study of Nitrendipine].
abstract: Nitrendipine (bypress) manufactured by Bayer Company in the form of 10 and 20 mg tablets and administered in a dose of 20-40 mg/day turned out an effective antihypertensive remedy in 65% of patients with arterial hypertension largely running a mild course. The effect of nitrendipine administered in a single daily dose of 20 mg did not differ from that attained with the same dose given in two intakes. The raising of the daily dose of nitrendipine from 20 to 40 mg was associated with augmentation of the hypotensive effect in 43.8% of the patients in whom the treatment in a dose of 20 mg a day had turned out ineffective. Under the conditions of the cross-over method with the use of the reference drugs belonging to three groups of the basic antihypertensive agents (nifedipine, propranolol, hydrochlorothiazide), the hypotensive effect of nitrendipine did not differ from that produced by the drugs under comparison (according to the mean group indicators and individual assessment of the efficacy). The tolerance of nitrendipine administered in a dose of 10 mg twice a day or in a dose of 20 mg once or twice a day was satisfactory.
authors.forename: V I
authors.initials: VI
authors.lastname: Metelitsa
authors.forename: T P
authors.initials: TP
authors.lastname: Ostrovskaia
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D004361:Drug Tolerance; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects / Q000627:therapeutic use; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000453:epidemiology; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000009:adverse effects / Q000627:therapeutic use; D009568:Nitrendipine / Q000009:adverse effects / Q000627:therapeutic use*; D011433:Propranolol / Q000009:adverse effects / Q000627:therapeutic use; D014586:USSR / Q000453:epidemiology
chemical_list: D008055:Lipids; D006852:Hydrochlorothiazide; D009568:Nitrendipine; D011433:Propranolol; D009543:Nifedipine
vernacular_title: Effektivnost' nitrendipina u bol'nykh stabil'noĭ arterial'noĭ gipertonieĭ. Dannye kooperativnogo issledovaniia v SSSR. Rabochaia gruppa kooperativnogo issledovaniia nitrendipina.