[The selectivity and protective properties of m-cholinolytics in dichlorodivinylphosphate poisoning].
The activity of selective and nonselective muscarinic antagonists was examined in different experimental models. According to the results obtained, the protective effect of muscarinic antagonists during acute dichlordivinyl phosphate (DDVP) poisoning depends on the M1-subtype cholinoreceptor blockade. Meanwhile the efficiency of muscarinic antagonists in inhibition of tremor reaction induced by arecoline administration is associated with interaction between the drugs and the M2-subtype. The blocking of presynaptic M2-cholinoreceptors is likely to cause the decrease of protective potency of muscarinic antagonists in acute DDVP poisoning.
Kosmachev
A B
AB
Iankhotova
M B
MB
Kosmacheva
I M
IM
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects; D004006:Dichlorvos / Q000506:poisoning*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D010276:Parasympatholytics / Q000627:therapeutic use*; D011041:Poisoning / Q000188:drug therapy / Q000453:epidemiology; D051381:Rats; D011976:Receptors, Muscarinic / Q000187:drug effects; D012044:Regression Analysis
D000931:Antidotes; D010276:Parasympatholytics; D011976:Receptors, Muscarinic; D004006:Dichlorvos
Selektivnost' i zashchitnye svoĭstva m-kholinolitikov pri otravlenii dikhlordivinilfosfatom.