Urea-hydrolysis-dependent citrulline synthesis by Ureaplasma urealyticum.
Some of the ammonia produced by hydrolysis of urea by Ureaplasma urealyticum is channelled into an anabolic pathway with resultant 'de novo' synthesis of citrulline. The organism appears to possess ornithine carbamoyltransferase and carbamoyl phosphate synthetase or some modified form of these enzymes.
Smith
D G
DG
School of Biological and Medical Sciences, St. Andrews University, UK.
Russell
W C
WC
Thirkell
D
D
D000641:Ammonia / Q000378:metabolism; D002222:Carbamoyl-Phosphate Synthase (Ammonia) / Q000378:metabolism; D002956:Citrulline / Q000096:biosynthesis*; D006868:Hydrolysis; D009954:Ornithine Carbamoyltransferase / Q000378:metabolism; D014508:Urea / Q000378:metabolism*; D014509:Ureaplasma / Q000378:metabolism*
D002956:Citrulline; D000641:Ammonia; D014508:Urea; D009954:Ornithine Carbamoyltransferase; D002222:Carbamoyl-Phosphate Synthase (Ammonia)