[Results of the treatment of Wilson's disease with zinc sulfate and d-penicillamine].
Nine patients with newly diagnosed Wilson's disease were treated with zinc sulphate for 12 months. Polish preparation Zincteral was administered in doses of 200 mg 4 times daily. The neurological status has improved in five cases. No adverse reactions of zinc sulphate were observed. The results were compared with the therapeutic effect, obtained in the group of 10 patients who received d-penicillamine (Cuprenil-Polfa) 1.0-1.5 g daily from the very beginning. In three cases drug was discontinued due to adverse reactions. In remaining seven cases, in five evidence of the clinical improvement of the neurological status was observed, but in one case during 12 months of observation progressing deterioration was noticed. Neurological state of one patient remained unchanged.
Szleper
M
M
Kliniki Chorób Naczyniowych Układu Nerwowego.
Rodo
M
M
Piłkowska
E
E
Członkowska
A
A
D000328:Adult; D004334:Drug Administration Schedule; D005260:Female; D006527:Hepatolenticular Degeneration / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010396:Penicillamine / Q000008:administration & dosage*; D012074:Remission Induction; D013431:Sulfates / Q000008:administration & dosage*; D013997:Time Factors; D015032:Zinc / Q000008:administration & dosage*; D019287:Zinc Sulfate
D013431:Sulfates; D019287:Zinc Sulfate; D010396:Penicillamine; D015032:Zinc
Wyniki leczenia choroby Wilsona siarczanem cynkowym i d-penicylamina.