title: Ivermectin and diethylcarbamazine trials in leaf monkeys (Presbytis cristatus) infected with Wuchereria kalimantani.
abstract: Clinical trials of Ivermectin in single oral doses of 200, 400, and 1,000 mg/kg body weight or in multiple doses of 200 mg/kg body weight for 5 consecutive days were performed in leaf monkeys (Presbytis cristatus) infected with Wuchereria kalimantani. Optimal microfilaricidal effect occurred at 200 mg/kg body weight. The drug was less effective than diethylcarbamazine in this animal model for human filariasis but had no adverse effects.
authors.affiliation: Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta.
authors.forename: A
authors.initials: A
authors.lastname: Kurniawan
authors.forename: E
authors.initials: E
authors.lastname: Sartono
authors.forename: W E
authors.initials: WE
authors.lastname: Setiowati
authors.forename: T
authors.initials: T
authors.lastname: Supali
authors.forename: H
authors.initials: H
authors.lastname: Wibowo
authors.lastname: Purnomo
authors.forename: B
authors.initials: B
authors.lastname: Rukmono
authors.forename: F
authors.initials: F
authors.lastname: Partono
mesh_terms: D000818:Animals; D002520:Cercopithecidae; D004049:Diethylcarbamazine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000882:Haplorhini; D007559:Ivermectin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008842:Microfilariae; D010272:Parasitic Diseases / Q000188:drug therapy*; D010919:Placebos; D014957:Wuchereria / Q000187:drug effects*
chemical_list: D010919:Placebos; D007559:Ivermectin; D004049:Diethylcarbamazine