title: [Inoperable brain metastases from bronchogenic cancers. Value of combined chemotherapy with cisplatin and 5 fluorouracil].
abstract: We report the results of a combined of chemotherapy with CDDP and 5 FU repeated every 3 weeks in sixteen men (age range 31-73 years) with brain metastases. CT was performed after 2, 4 and 6 cycles to assess efficiency. Response was considered complete when no lesion was found on the CT scan and partial when the lesion shrunk to least half its the total volume. After two cycles, the response rate was 8/16 (50%). Treatment toxicity was mild with only one case of severe but reversible myelotoxicity (grade III). CDDP and 5 FU combined chemotherapy can be a useful treatment for brain metastasis of lung carcinoma.
authors.affiliation: Service de Pneumologie et d'Oncologie broncho-pulmonaire, CHU Brest.
authors.forename: G
authors.initials: G
authors.lastname: Robinet
authors.forename: P
authors.initials: P
authors.lastname: Richard
authors.forename: F
authors.initials: F
authors.lastname: Rouhart
authors.forename: Y
authors.initials: Y
authors.lastname: Mocquard
authors.forename: J Y
authors.initials: JY
authors.lastname: Goas
authors.forename: N
authors.initials: N
authors.lastname: André
authors.forename: S
authors.initials: S
authors.lastname: Gouva
authors.forename: J
authors.initials: J
authors.lastname: Clavier
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002283:Carcinoma, Bronchogenic / Q000473:pathology*; D002945:Cisplatin / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
chemical_list: D002945:Cisplatin; D005472:Fluorouracil
vernacular_title: Les métastases cérébrales inopérables des cancers bronchiques. Intérêt d'une chimiothérapie associant cisplatine et 5 fluoro-uracile.