[Severe exacerbation of chronic hepatitis B following interferon therapy].
A patient with chronic active hepatitis B was treated with interferon alpha. Inhibition of HBV replication was associated with severe exacerbation of hepatitis. Treatment of chronic hepatitis B with interferon may lead to transient decompensation of liver function, especially in patients with high activity of morphological changes.
Laskus
T
T
Zakładu Immunopatologii Instytutu Chorób Zakaźnych i Pasozytniczych Ak. Med., Warszawie.
Radkowski
M
M
Cianciara
J
J
Loch
T
T
Slusarczyk
J
J
D006509:Hepatitis B / Q000382:microbiology / Q000503:physiopathology / Q000628:therapy*; D006515:Hepatitis B virus / Q000187:drug effects / Q000502:physiology; D006521:Hepatitis, Chronic / Q000382:microbiology / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects / Q000382:microbiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D014779:Virus Replication / Q000187:drug effects / Q000502:physiology
D016898:Interferon-alpha
Ciezkie zaostrzenie przewlekłego zapalenia watroby typu B po leczeniu interferonem.