Alloimmune neonatal neutropenia is a potential side effect of immunization with leukocytes in women with recurrent spontaneous abortions.
Alloimmunization of a mother against granulocytes causing alloimmune neonatal neutropenia (ANN) in her newborn was found likely to be attributed to previous intradermal injections of paternal lymphocytes. Immunotherapy with leukocytes which was performed for recurrent spontaneous abortions hence provides the possibility of granulocyte alloimmunization and increases the risk of the occurrence of ANN.
Bux
J
J
Institute for Clinical Immunology and Transfusion Medicine, University of Giessen, FRG.
Westphal
E
E
de Sousa
F
F
Mueller-Eckhardt
G
G
Mueller-Eckhardt
C
C
D000026:Abortion, Habitual / Q000276:immunology / Q000628:therapy*; D000328:Adult; D005260:Female; D006801:Humans; D007114:Immunization; D007158:Immunologic Techniques; D007167:Immunotherapy / Q000009:adverse effects*; D017708:Leukocyte Transfusion; D007962:Leukocytes / Q000276:immunology; D009503:Neutropenia / Q000151:congenital* / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D011247:Pregnancy