title: Plasma cholinesterase isozymes and REM latency in schizophrenia.
abstract: The relation between electroencephalographic sleep parameters and plasma cholinesterase isozymes was examined in a group of 19 unmedicated schizophrenic patients. Rapid eye movement (REM) latency was found to be significantly inversely correlated with isozyme 3 (mainly acetylcholinesterase). The results are discussed in relation to cholinergic involvement in the regulation of REM sleep and in the pathophysiology of schizophrenia.
authors.affiliation: Dept. of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213.
authors.forename: M S
authors.initials: MS
authors.lastname: Keshavan
authors.forename: S P
authors.initials: SP
authors.lastname: Mahadik
authors.forename: C F
authors.initials: CF
authors.lastname: Reynolds
authors.forename: S
authors.initials: S
authors.lastname: Mukerjee
authors.forename: A
authors.initials: A
authors.lastname: Korenovsky
authors.forename: P
authors.initials: P
authors.lastname: Houck
authors.forename: D B
authors.initials: DB
authors.lastname: Jarrett
mesh_terms: D000328:Adult; D002802:Cholinesterases / Q000097:blood*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D008297:Male; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000201:enzymology* / Q000503:physiopathology; D012565:Schizophrenic Psychology; D012895:Sleep, REM / Q000502:physiology*; D013997:Time Factors
chemical_list: D007527:Isoenzymes; D002802:Cholinesterases