title: Inflammatory familial palmoplantar keratoderma: Greither's disease?
abstract: A case of a familial palmoplantar inflammatory keratoderma with autosomal dominant inheritance is reported. Associated clinical features included vasomotor troubles and hyperhidrosis consistent with a diagnosis of Greither's disease. Light microscopy was nonspecific. Electron microscopy showed aggregated tonofilaments around the nucleus, without true clumps. Desmosomes were numerous and cell-cell junctions showed an imbricated pattern, well demonstrated in the stratum corneum. The diagnosis of Greither's keratoderma is discussed.
authors.affiliation: Service de Dermatologie, Hôpital des Enfants, Bordeaux, France.
authors.forename: M
authors.initials: M
authors.lastname: Beylot-Barry
authors.forename: A
authors.initials: A
authors.lastname: Taïeb
authors.forename: J E
authors.initials: JE
authors.lastname: Surlève-Bazeille
authors.forename: J
authors.initials: J
authors.lastname: Maleville
mesh_terms: D000328:Adult; D002675:Child, Preschool; D004487:Edema / Q000150:complications; D005260:Female; D006801:Humans; D007249:Inflammation; D007645:Keratoderma, Palmoplantar / Q000150:complications / Q000235:genetics* / Q000473:pathology*; D008297:Male; D012867:Skin / Q000473:pathology / Q000648:ultrastructure