[A case of hyperalphalipoproteinemia with complete deficiency of cholesteryl ester transfer activity].
A 68-year-old male patient with benign hypertension shows high levels of high density lipoprotein cholesterol (HDL-C) of 171 mg/dl. The serum total cholesterol was 240 mg/dl. An abnormal slow alpha band and polydisperse low density lipoprotein (LDL) bands were detected by agarose gel and polyacrylamide gel electrophoresis. The slow alpha band was considered as an apo E-rich HDL. A peak of large HDL particle and a peak of abnormal high-molecular-LDL particle were observed in the patient's serum by gel permeation high performance liquid chromatography. Cholesteryl ester transfer activity (CETA) of the patient's serum was completely deficient (0.0%/10 microliters/18 hr). From these results, it is strongly suggested that patient's hyper-HDL-cholesterolemia caused by a complete deficiency of CETA.
Umemori
Y
Y
Clinical Laboratories, Asahikawa Medical College Hospital.
Moriyama
T
T
Takeda
S
S
Hosokawa
H
H
Nobuoka
M
M
Makino
M
M
Matuhashi
H
H
Eto
M
M
Sakai
N
N
Chiba
H
H
D000368:Aged; D002352:Carrier Proteins / Q000032:analysis*; D053480:Cholesterol Ester Transfer Proteins; D002851:Chromatography, High Pressure Liquid; D004586:Electrophoresis; D006023:Glycoproteins; D006801:Humans; D006951:Hyperlipoproteinemias / Q000209:etiology*; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male
C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D006023:Glycoproteins; D008075:Lipoproteins, HDL