title: Factors associated with intestinal amyloidosis in pigtailed macaques (Macaca nemestrina).
abstract: Factors associated with intestinal amyloidosis in pigtailed macaques (Macaca nemestrina) were studied in 74 cases at the Washington Regional Primate Research Center. The medical records of monkeys during the 5-year period from 1983 to 1988 were analyzed to determine the age at death, age at first episode of diarrhea, number of episodes of diarrhea, episode and cumulative duration of diarrhea, and etiologies of diarrhea. Univariate analysis, using one control for each case, indicated that only episode duration was related to intestinal amyloidosis. Affected monkeys had significantly longer mean episode durations of diarrhea. None of the etiologies examined--bacteria, protozoa, fungi, and simian retrovirus--were significant risk factors for amyloid deposition in the intestinal tract.
authors.affiliation: Department of Comparative Medicine, School of Medicine, University of Washington, Seattle 98195.
authors.forename: L
authors.initials: L
authors.lastname: Ellsworth
authors.forename: S
authors.initials: S
authors.lastname: Farley
authors.forename: R F
authors.initials: RF
authors.lastname: DiGiacomo
authors.forename: C C
authors.initials: CC
authors.lastname: Tsai
mesh_terms: D000367:Age Factors; D000686:Amyloidosis / Q000209:etiology / Q000662:veterinary*; D000818:Animals; D003967:Diarrhea / Q000453:epidemiology / Q000662:veterinary; D005260:Female; D007410:Intestinal Diseases / Q000209:etiology / Q000662:veterinary*; D008254:Macaca nemestrina; D008297:Male; D008992:Monkey Diseases / Q000209:etiology*; D012307:Risk Factors