title: Ibudilast may improve retinal circulation in patients with diabetes mellitus.
abstract: Ibudilast selectively vasodilates cerebral vessels without reducing blood pressure. We investigated the effect of the drug on retinal circulation in 8 patients with diabetes mellitus, using the video-densitometric image analysis of fluorescein angiography. We compared the build up time, the time constant of washout rate and the mean circulation time (MCT) before and after oral therapy with ibudilast. After 2 weeks of daily administration (30 mg), MCT was shortened significantly (4.2 +/- 2.8 vs. 3.0 +/- 1.6 s, p = 0.0215). Since retinal circulation in patients with diabetes mellitus was improved by ibudilast, the drug may be useful to treat disorders such as diabetic retinopathy.
authors.affiliation: Department of Ophthalmology, Yamaguchi University School of Medicine, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Suzuki
authors.forename: I
authors.initials: I
authors.lastname: Sugihara
authors.forename: T
authors.initials: T
authors.lastname: Ishibashi
authors.forename: S
authors.initials: S
authors.lastname: Kurimoto
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure; D048909:Diabetes Complications; D003930:Diabetic Retinopathy / Q000188:drug therapy*; D005260:Female; D005451:Fluorescein Angiography; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D011725:Pyridines / Q000008:administration & dosage / Q000627:therapeutic use*; D012171:Retinal Vessels / Q000502:physiology; D014665:Vasodilator Agents / Q000008:administration & dosage*; D014741:Video Recording; D007212:Indolizines; D011720:Pyrazoles
chemical_list: D011725:Pyridines; D014665:Vasodilator Agents; C038366:ibudilast; D007212:Indolizines; D011720:Pyrazoles