[A study of inhibitory effect of chondroitin polysulfate on stone formation of calcium oxalate].
Chondroitin polysulfate (CPS) have inhibitory activity on stone formation of calcium oxalate. This study compared the inhibitory effect of three CPS (CPS S-I, CPS S-II, CPS S-III) with sodium pentosan polysulfate (SPP) and chondroitin sulfate (CS). Crystal growth inhibition was measured in a seeded crystal growth system with 14C-oxalate, and CPS S-I and CPS S-II were the most active substances inhibiting crystal growth. Since CPS S-II and CPS S-III had remarkable hemorrhagic adverse effect, these two substances were excluded from the following study. The study of administration of the rest of the substances (CPS S-I, SPP, CS) to rats revealed that CPS S-I highly inhibited formation of stone in kidney. About 65 percent of CPS S-I administered subcutaneously was excreted in 24 hours urine. Therefore it may be of value to study clinical usefulness of CPS S-I for treatment of patient with urolithiasis.
Fujisawa
M
M
Department of Urology, Asahikawa Medical College.
Arima
S
S
Yachiku
S
S
D000818:Animals; D002129:Calcium Oxalate / Q000378:metabolism*; D002809:Chondroitin Sulfates / Q000494:pharmacology*; D003460:Crystallization; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014545:Urinary Calculi / Q000737:chemistry / Q000517:prevention & control*
D002129:Calcium Oxalate; D002809:Chondroitin Sulfates