title: Parasitological and histopathological studies on rhesus monkeys infected with Chinese mainland strain of Schistosoma japonicum.
abstract: Fifteen rhesus monkeys were infected by cutaneous exposure each with 200 or 300 cercariae of Schistosoma japonicum. The dynamic distribution of schistosomula in the skin showed that 77-90% of them were found in the connective tissue, while 10-23% migrated in the hair follicles and sebaceous glands at different time intervals after cercarial penetration. Dead schistosomula recovered from the skin varied from 8.7% to 28.7%. The average rate of adult worm recovery was 74.4% and 61.3% in the 6th and 15th weeks of infection, thereafter the rate decreased to 32.3% and 9.0% in the 19th and 42nd weeks, respectively. The mean length of mature pair-worms was 13.2 +/- 2.3 mm in male and 18.0 +/- 1.9 mm in female 6 weeks of worm age. Afterwards the body length of females and their sexual gland diminished markedly. The mean prepatent period was 35.0 +/- 0.6 days. The average size of mature eggs in the feces was 86.6 +/- 5.4 x 64.3 +/- 3.6 microns, and the peak of eggs passage in the feces occurred between 7th and 15th weeks after infection, later on the number of eggs markedly decreased. Skin reaction to the primary infection was slight. The pathological changes observed in liver were chiefly cellular infiltration of portal spaces and the lesions produced by egg granulomas. The mean volume of single-egg granulomas of the productive stage in liver was 22.7 +/- 10.5 mm3 x 10(-3). The most intensive damages in the gastro-intestinal tract were observed in the large intestine.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Chinese Academy of Preventive Medicine, WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai, People's Republic of China.
authors.forename: Y X
authors.initials: YX
authors.lastname: He
authors.forename: Q F
authors.initials: QF
authors.lastname: Yu
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Hu
mesh_terms: D000818:Animals; D002681:China; D005243:Feces / Q000469:parasitology; D005260:Female; D007422:Intestines / Q000469:parasitology / Q000473:pathology; D008099:Liver / Q000469:parasitology / Q000473:pathology; D008253:Macaca mulatta; D008297:Male; D010270:Parasite Egg Count; D012549:Schistosoma japonicum / Q000302:isolation & purification*; D012554:Schistosomiasis japonica / Q000469:parasitology / Q000473:pathology*; D012867:Skin / Q000469:parasitology / Q000473:pathology