[The interaction of the immune system and the liver mono-oxygenase system].
The effect of different immunostimulants (prodigiosan, levamisole, T-activin, sodium diethyl dithiocarbamate, sodium nucleinate, lithium chloride, muramil dipeptide, B-activin) and mixed hepatic function oxidase inhibitors (cimetidine, chloramphenicol) or inducers (phenobarbital, flumecinol, rifampicin) on immune reactivity (macrophage function, humoral and cellular responses) and hepatic microsomal function (hexobarbital sleeping-time) was studied in non-inbred and BALB/c male mice. There was a high correlation between the ability of immunostimulants to depress hexobarbital metabolism and their ability to enhance macrophage activity (carbon clearance test), but not humoral and cellular immunity. No reciprocal changes occurred in immune reactivity after positive or negative pharmacological modulation of hepatic drug metabolizing enzyme activity.
Sibiriak
S V
SV
Krasilova
I L
IL
Riabchinskaia
L A
LA
Volkova
S S
SS
Bogdanova
A Sh
ASh
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D004790:Enzyme Induction / Q000187:drug effects; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007107:Immune System / Q000187:drug effects* / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology* / Q000276:immunology; D010105:Oxygenases / Q000096:biosynthesis / Q000187:drug effects*
D000276:Adjuvants, Immunologic; D010105:Oxygenases
K voprosu o vzaimodeĭstvii immunnoĭ sistemy i monooksigenaznoĭ sistemy pecheni.