title: Local antibiotic prophylaxis in inguinal hernia repair.
abstract: We compared the effects of single dose (750 milligrams) prophylactic cefamandole delivered directly into the operative wound with local anesthesia (n = 162) with a control group (no antibiotics) (n = 162) in a randomized trial. No adverse effects were observed. There were seven wound abscesses in the untreated group compared with none in the group receiving antibiotic prophylaxis (p = 0.007). Six of the seven abscesses occurred as late as one month after the patient was discharged from the hospital. The costs of antibiotics used were ten times less than the costs of treatment of wound complications in the control group.
authors.affiliation: Service de Chirurgie Digestive, Hôpital Purpan, Toulouse, France.
authors.forename: F
authors.initials: F
authors.lastname: Lazorthes
authors.forename: P
authors.initials: P
authors.lastname: Chiotasso
authors.forename: P
authors.initials: P
authors.lastname: Massip
authors.forename: J P
authors.initials: JP
authors.lastname: Materre
authors.forename: M
authors.initials: M
authors.lastname: Sarkissian
mesh_terms: D000038:Abscess / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002435:Cefamandole / Q000008:administration & dosage / Q000191:economics / Q000627:therapeutic use*; D002648:Child; D003131:Combined Modality Therapy; D016527:Drug Costs; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006552:Hernia, Inguinal / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008012:Lidocaine / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control; D011795:Surveys and Questionnaires
chemical_list: D002435:Cefamandole; D008012:Lidocaine