title: Energetics of methanogenesis studied in vesicular systems.
abstract: Methanogenesis is restricted to a group of prokaryotic microorganisms which thrive in strictly anaerobic habitats where they play an indispensable role in the anaerobic food chain. Methanogenic bacteria possess a number of unique cofactors and coenzymes that play an important role in their specialized metabolism. Methanogenesis from a number of simple substrates such as H2 + CO2, formate, methanol, methylamines, and acetate is associated with the generation of transmembrane electrochemical gradients of protons and sodium ions which serve as driving force for a number of processes such as the synthesis of ATP via an ATP synthase, reverse electron transfer, and solute uptake. Several unique reactions of the methanogenic pathways have been identified that are involved in energy transduction. Their role and importance for the methanogenic metabolism are described.
authors.affiliation: Institut für Mikrobiologie, Georg-August-Universität Göttingen, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Blaut
authors.forename: V
authors.initials: V
authors.lastname: Müller
authors.forename: G
authors.initials: G
authors.lastname: Gottschalk
mesh_terms: D000255:Adenosine Triphosphate / Q000096:biosynthesis; D004579:Electron Transport; D004734:Energy Metabolism; D019605:Euryarchaeota / Q000737:chemistry / Q000201:enzymology / Q000378:metabolism*; D008697:Methane / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D013816:Thermodynamics
chemical_list: D000255:Adenosine Triphosphate; D012964:Sodium; D008697:Methane