Ventroposterolateral pallidotomy can abolish all parkinsonian symptoms.
Stereotactic ventroposterolateral pallidotomy in 46 parkinsonian patients resulted in a complete or almost complete and long-lasting relief of rigidity and hypokinesia in 91% of the patients. Good tremor effect was obtained in 80% of them. The L-dopa-induced dyskinesias, gait and speech improved in most patients. Complications were observed in 7 cases after 51 pallidotomies, i.e. 14% (partial homonymous hemianopia in 6 and transient dysphasia and facial weakness in 1). We believe that the good effect of surgery is based on interruption of some striopallidal or subthalamopallidal pathways.
Laitinen
L V
LV
Department of Neurosurgery, Sophiahemmet Hospital, Stockholm, Sweden.
Bergenheim
A T
AT
Hariz
M I
MI
D004421:Dystonia / Q000503:physiopathology; D004558:Electric Stimulation; D005684:Gait; D005917:Globus Pallidus / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D010146:Pain / Q000503:physiopathology; D010300:Parkinson Disease / Q000503:physiopathology / Q000601:surgery*; D012189:Retrospective Studies; D013060:Speech; D013238:Stereotaxic Techniques