The distribution of the tumour photosensitizers Zn(II)-phthalocyanine and Sn(IV)-etiopurpurin among rabbit plasma proteins.
Zn-phthalocyanine (ZnPc) and Sn-etiopurpurin (SnET2) incorporated in unilamellar liposomes or solubilized in a Cremophor-EL emulsion have been incubated in vitro with rabbit plasma or intravenously administered to rabbits. Ultracentrifugation and chromatographic analysis of the plasma showed that ZnPc and SnET2 are mainly released to lipoproteins; within the lipoprotein family, both dyes are preferentially bound by low-density (LDL) and high-density (HDL) lipoproteins. The amount of dye bound with these two lipoprotein classes was related to their relative concentration in the plasma; in most cases a larger amount of photosensitizer was bound to HDL as compared to LDL on a protein concentration basis.
Polo
L
L
Department of Biology, University of Padua, Italy.
Reddi
E
E
Garbo
G M
GM
Morgan
A R
AR
Jori
G
G
D015060:1,2-Dipalmitoylphosphatidylcholine; D000818:Animals; D001798:Blood Proteins / Q000302:isolation & purification / Q000378:metabolism*; D004655:Emulsions; D005990:Glycerol / Q000031:analogs & derivatives; D007211:Indoles / Q000097:blood*; D054833:Isoindoles; D008074:Lipoproteins / Q000097:blood* / Q000302:isolation & purification; D008081:Liposomes; D009942:Organometallic Compounds / Q000097:blood*; D014677:Pharmaceutical Vehicles; D011166:Porphyrins / Q000097:blood; D011817:Rabbits; D011838:Radiation-Sensitizing Agents / Q000378:metabolism*; D017967:Zinc Compounds
D001798:Blood Proteins; D004655:Emulsions; D007211:Indoles; D054833:Isoindoles; D008074:Lipoproteins; D008081:Liposomes; D009942:Organometallic Compounds; D014677:Pharmaceutical Vehicles; D011166:Porphyrins; D011838:Radiation-Sensitizing Agents; D017967:Zinc Compounds; C052159:Zn(II)-phthalocyanine; D015060:1,2-Dipalmitoylphosphatidylcholine; C063166:tin etiopurpurin; C000515:cremophor EL; D005990:Glycerol