[The antioxidant treatment of patients with acute intestinal infections due to gram-negative microorganisms].
It was established that administration of S. typhimurium lysate causes activation of the processes of free-radical oxidation. Introduction of unithiol in combination with magnesium sulfate returns the intensity of these processes to the initial level. Unithiol and alpha-tocopherol acetate protect the animals form lethal effects of S. sonnei lysate. Use of a combination of pharmacological agents consisting of unithiol, magnesium sulfate and alpha-tocopherol acetate in the treatment of patients with acute intestinal infections due to gram-negative pathogens (shigellae, salmonellae, proteus, klebsiellae, pseudomonas) resulted in decrease of the length of the intoxication and diarrhea syndrome, decrease of the frequency of repeat bacteria elimination and protracted forms of these infections, more rapid normalization of immune system functions.
Grutman
M I
MI
Frolov
V M
VM
Peresadin
N A
NA
Pshenichnyĭ
I Ia
IIa
Nagornaia-Persidskaia
N A
NA
Varich
V Ia
VIa
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D007410:Intestinal Diseases / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008875:Middle Aged
D000975:Antioxidants
Lechenie antioksidantami bol'nykh ostrymi kishechnymi infektsiiami, vyzvannymi gramotritsatel'nymi mikroorganizami.