[The electronic structure and radiorprotective activity of a series of substituted iminodihydrofurans].
Compounds that increase the survival rate of lethally exposed hybrid (CBA x C57B1/6)F1 mice have been revealed within the series of iminodihydrofurans. The quantum-chemical estimates, made by the MNDO method, show that substances which are capable of donor-acceptance interaction with DNA nucleotides and have the energy of donor orbitals, comparable with the electron structure of nucleotides, possess radioprotective efficacy.
Khutorskaia
E E
EE
Beloglazov
G S
GS
Izmozherova
E L
EL
Filaretov
A N
AN
Skvortsov
Iu M
IuM
D000818:Animals; D005663:Furans / Q000737:chemistry / Q000627:therapeutic use* / Q000633:toxicity; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000737:chemistry / Q000627:therapeutic use* / Q000633:toxicity; D051381:Rats
D005663:Furans; D011837:Radiation-Protective Agents
Elektronnaia struktura i radiozashchitnaia aktivnost' v riadu zameshchennykh iminodigidrofuranov.