title: Spontaneous coronary arterial dissection and isolated eosinophilic coronary arteritis: sudden cardiac death in a patient with a limited variant of Churg-Strauss syndrome.
abstract: Isolated eosinophilic coronary arteritis expressed as a limited variant of the Churg-Strauss syndrome (allergic granulomatosis and angiitis) is a rare condition. Equally as rare is the entity of isolated spontaneous coronary arterial dissection associated with eosinophilic arteritis. A 57-year-old woman with a history of asthma and recurrent hypersensitivity (anaphylactoid) reactions to various exogenous allergens was found dead in her home; no premonitory complaints had been noted during the preceding days. Autopsy revealed focal occlusion of the left anterior descending and first diagonal coronary arteries by discrete dissecting hematomas of the media as the cause of sudden and unexpected death. Histologically, the affected arterial wall showed eosinophilic inflammation characteristic of this limited expression of the Churg-Strauss syndrome. To our knowledge, sudden cardiac death caused by arterial dissection in isolated eosinophilic coronary arteritis has not previously been reported.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Kentucky College of Medicine, Lexington 40507-2103.
authors.forename: J C
authors.initials: JC
authors.lastname: Hunsaker
authors.forename: W N
authors.initials: WN
authors.lastname: O'Connor
authors.forename: J T
authors.initials: JT
authors.lastname: Lie
mesh_terms: D001167:Arteritis / Q000150:complications* / Q000473:pathology; D001344:Autopsy; D015267:Churg-Strauss Syndrome / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D003327:Coronary Disease / Q000150:complications* / Q000473:pathology; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D004802:Eosinophilia / Q000150:complications* / Q000473:pathology; D005260:Female; D006406:Hematoma / Q000150:complications* / Q000473:pathology; D006801:Humans; D008875:Middle Aged