Influence of a stable prostacyclin analogue, Cicaprost, on the response to prostaglandin F2 alpha in the perfused human placenta.
Because a balance between the vasodilator effect of Prostacyclin and the vasoconstrictor effect of Prostaglandin F2 alpha (PGF2 alpha) may be necessary for the regulation of utero-placental-fetal blood flow, a study was designed to assess the influence of a stable prostacyclin analogue, Cicaprost, on the response to Prostaglandin F2 alpha in the perfused human placenta. Cicaprost produced a dose-dependent inhibition of the pressor response of 50 mcg of PGF2 alpha. The decrease in PGF2 alpha-induced pressor response by 0.1 mcg of Cicaprost was not significant, only 6.95 +/- 8.2%. However, 0.5 mcg and 1.0 mcg of Cicaprost significantly attenuated the pressor response of PGF2 alpha by 36.6 +/- 9.5% and 46.8 +/- 8.3%, respectively (MEAN +/- S.E.).
Bhamidi
S
S
Department of Pharmacology, Temple University School of Pharmacy, Philadelphia, PA 19140.
Gautieri
R F
RF
D001794:Blood Pressure / Q000187:drug effects; D015237:Dinoprost / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D011464:Epoprostenol / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D010477:Perfusion; D010920:Placenta / Q000098:blood supply / Q000187:drug effects*; D011247:Pregnancy; D014662:Vasoconstrictor Agents / Q000494:pharmacology
D014662:Vasoconstrictor Agents; D015237:Dinoprost; D011464:Epoprostenol; C043867:cicaprost