Modulators of free radical activity in diabetes mellitus: role of ascorbic acid.
Free radical mechanisms are increasingly being implicated in the pathogenesis of tissue damage in diabetes. Various sources of free radicals may modulate oxidative stress in diabetes, including non-enzymatic glycosylation of proteins and monosaccharide autooxidation, polyol pathway activity, indirect production of free radicals through cell damage from other causes, and reduced antioxidant reserve. Ascorbic acid, which may be a principal modulator of free radical activity in diabetes, is shown to be consumed, presumably through free radical scavenging, thus preserving levels of other antioxidants such as glutathione.
Sinclair
A J
AJ
University Department of Geriatric Medicine, University of Wales College of Medicine, Cardiff, UK.
Lunec
J
J
Girling
A J
AJ
Barnett
A H
AH
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001205:Ascorbic Acid / Q000378:metabolism* / Q000494:pharmacology*; D003920:Diabetes Mellitus / Q000378:metabolism* / Q000473:pathology; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism / Q000473:pathology; D016166:Free Radical Scavengers; D005609:Free Radicals / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D008954:Models, Biological; D013012:Sorbitol / Q000378:metabolism
D000975:Antioxidants; D016166:Free Radical Scavengers; D005609:Free Radicals; D013012:Sorbitol; D001205:Ascorbic Acid