Autoantibodies against cyclophilin in systemic lupus erythematosus and Lyme disease.
Autoantibodies against cyclophilin, a cyclosporin A binding protein, were detected in sera of 29 of 46 (63%) patients with systemic lupus erythematosus and 14 of 40 (35%) Lyme disease patients. The antibodies are directed against the denatured form of both the major and minor isoform of cyclophilin and can be demonstrated in Western blots. Some first-degree relatives of lupus patients also express these antibodies. They are specific for cyclophilin and are not the consequence of hypergammaglobulinaemia. Four monoclonal IgM antibodies from a patient with lepromatous leprosy also bound to cyclophilin. The generation of these antibodies may be of special interest because they are against a protein involved in the control of the immune system not known to be directly associated with DNA or RNA.
Kratz
A
A
Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510.
Harding
M W
MW
Craft
J
J
Mackworth-Young
C G
CG
Handschumacher
R E
RE
D000293:Adolescent; D000328:Adult; D000368:Aged; D000591:Amino Acid Isomerases / Q000276:immunology*; D000888:Antibodies, Anti-Idiotypic / Q000097:blood; D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D002352:Carrier Proteins / Q000276:immunology*; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005192:Family Health; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007130:Immunoglobulin Idiotypes / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000276:immunology*; D008193:Lyme Disease / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D019696:Peptidylprolyl Isomerase; D011489:Protein Denaturation
D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D002352:Carrier Proteins; D007074:Immunoglobulin G; D007130:Immunoglobulin Idiotypes; D007075:Immunoglobulin M; C044203:anti-IgM; D000591:Amino Acid Isomerases; D019696:Peptidylprolyl Isomerase