title: Increased sensitivity of guinea pig gallbladder in vitro to bradykinin.
abstract: Bradykinin evoked concentration dependent contractions of guinea pig gallbladder smooth muscle strips in vitro. Responses to kinins increase over three hours of incubation. Induction of a B1-mediated action, waning activity of endogenous kininase(s) and involvement of eicosanoids as mediators have been investigated as potential contributing mechanisms to the four-fold, time dependent increase in response of this tissue to bradykinin.
authors.affiliation: Department of Pharmacology, University College Dublin, Ireland.
authors.forename: M
authors.initials: M
authors.lastname: Woods
authors.forename: A W
authors.initials: AW
authors.lastname: Baird
mesh_terms: D000818:Animals; D001920:Bradykinin / Q000031:analogs & derivatives / Q000494:pharmacology*; D002217:Carbachol / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology; D005704:Gallbladder / Q000187:drug effects / Q000502:physiology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007213:Indomethacin; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D010894:Piroxicam / Q000494:pharmacology; D011480:Protease Inhibitors / Q000494:pharmacology; D013997:Time Factors
chemical_list: D011480:Protease Inhibitors; D010894:Piroxicam; C024626:bradykinin, des-Arg(9)-; D002217:Carbachol; D003513:Cycloheximide; D001920:Bradykinin; D007213:Indomethacin