Non-right sidedness: an association with lower IL-2 production.
Using a laterality questionnaire, 138 normal healthy individuals were classified as right-sided and 25 as non-right sided. Interleukin-2 (IL-2) was generated from whole blood obtained from these subjects using mitogen (PHA) stimulation. IL-2 was quantitated in picograms/ml using an enzyme immunoassay (ELISA). Additionally, sera from these subjects were tested for 7 autoantibodies by standard serological methods. As compared to right sided subjects, non-right sided individuals had significantly lower IL-2 production. Non-right sided individuals with autoantibodies had significantly lower IL-2 production than right sided subjects with or without autoantibodies, but did not differ significantly from their non-right sided counterparts without autoantibodies. These data support the increasing evidence for the differential and lateralized regulation of immune functions by the right and left cerebral regions.
Chengappa
K N
KN
Brain, Behaviour and Immunity Center, University of Pittsburgh, PA 15213-2593.
Ganguli
R
R
Yang
Z W
ZW
Schurin
G
G
Cochran
J
J
Brar
J S
JS
Rabin
B
B
D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D001921:Brain / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007376:Interleukin-2 / Q000097:blood*; D008297:Male; D011795:Surveys and Questionnaires
D001323:Autoantibodies; D007376:Interleukin-2