Understanding the role of oxyradicals in general and in toxic hepatic damage can help safer drug design.
The existence and importance of free radicals are well established both theoretically and in in vivo experiments. Methods and techniques are now available to demonstrate the formation of free radical metabolites of natural substances and xenobiotics. Theories of the biological effects of free radicals could be unified and used for a better understanding of the complex processes of the organism. Pharmacology can gain profit from this multidisciplinary approach, which helps to design safer drugs. The theories of free radicals and the results of experiments with antioxidants could help to decrease the oxidative stress caused by pharmaceutical chemicals.
Varga
M
M
Department of Forensic Medicine, Medical University of Debrecen, Hungary.
D000818:Animals; D001711:Biotransformation; D015195:Drug Design; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000293:injuries / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012449:Safety
D017382:Reactive Oxygen Species