title: The kallikrein-kinin system in early state of diabetes.
abstract: The kallikrein-kinin system was studied in 9 normals, healthy subjects (6 men, 3 women, age range 1 to 14 years) and 15 diabetic patients (9 men, 6 women age range 2 to 14 years) with an evolution of the disease between 1 to 14 years. Diabetic patients with low microalbuminuria (6.62 +/- 0.97 mg/24 h) show increased total and pre-kallikrein respect to control (3 and 2 fold respectively). On the other hand patients with high microalbuminuria (44.7 +/- 13.2 mg/24 h) show a total and pre-kallikrein of more than 4 and 8 fold increased respectively, compare with the control. According with these results we can concluded: 1) The total kallikrein and pre-kallikrein is increased in the diabetic state. 2) When microalbuminuria is high, the total and pre-kallikrein correlates with those increasing. 3) These changes could modified the renal hemodynamic in diabetes.
authors.affiliation: Cátedra de Fisiología, Facultad de Farmacia y Bioquímica, Hospital General de Niños Dr. Pedro Elizalde, Buenos Aires, Argentina.
authors.forename: S B
authors.initials: SB
authors.lastname: Vila
authors.forename: V A
authors.initials: VA
authors.lastname: Peluffo
authors.forename: C
authors.initials: C
authors.lastname: Alvarado
authors.forename: J C
authors.initials: JC
authors.lastname: Cresto
authors.forename: A
authors.initials: A
authors.lastname: Zuccollo
authors.forename: O L
authors.initials: OL
authors.lastname: Catanzaro
mesh_terms: D000293:Adolescent; D000419:Albuminuria; D002648:Child; D002675:Child, Preschool; D003920:Diabetes Mellitus / Q000201:enzymology / Q000503:physiopathology / Q000652:urine*; D005260:Female; D005919:Glomerular Filtration Rate; D006029:Glycosuria; D006801:Humans; D007223:Infant; D007610:Kallikreins / Q000652:urine*; D008297:Male; D011288:Prekallikrein / Q000652:urine; D012016:Reference Values
chemical_list: D011288:Prekallikrein; D007610:Kallikreins