Chloramine T impairs the receptor-mediated endocytosis of plasma kallikrein by the liver.
Treatment of rat plasma-kallikrein with chloramine T (which does not affect neither its amidolytic activity nor its Mr) impairs the hepatic clearance of the enzyme in a dose-related manner. Preperfusion of the liver with chloramine T before the addition of plasma-kallikrein also diminishes the hepatic clearance of the enzyme.
Borges
D R
DR
Department of Medicine, Escola Paulista de Medicina, Sao Paulo, Brasil.
Kouyoumdjian
M
M
D000818:Animals; D037263:Asialoglycoprotein Receptor; D002700:Chloramines / Q000494:pharmacology*; D004202:Disinfectants / Q000494:pharmacology; D004705:Endocytosis / Q000187:drug effects*; D007610:Kallikreins / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011971:Receptors, Immunologic / Q000187:drug effects / Q000378:metabolism*; D014105:Tosyl Compounds
D037263:Asialoglycoprotein Receptor; D002700:Chloramines; D004202:Disinfectants; D011971:Receptors, Immunologic; D014105:Tosyl Compounds; C016300:chloramine-T; D007610:Kallikreins