title: Oscillatory mechanics of the respiratory system in neuromuscular disease.
abstract: Respiratory impedance measurements by means of the technique of forced oscillations together with spirometry and measurements of maximal mouth pressures were performed in 27 patients with a variety of neuromuscular disorders to assess the value of adding respiratory impedance measurements in the evaluation of lung function in neuromuscular disease. Using the technique of forced oscillations, impedance measurements are easily performed in physically disabled persons, since they require little active cooperation and no forced respiratory maneuvers. Normal respiratory impedance characteristics were found, although resistance values were somewhat higher than those found in normal subjects, signifying the absence of airflow limitation. Spirometric values were markedly reduced, as were maximal mouth pressures. No significant correlations were found between the forced expiratory volumes in 1 s (FEV1) and the impedance data. A strong curvilinear relationship was observed between Pemax and the RV/TLC ratio and a strong correlation existed between FEV1 and Premax. It is concluded from our study that forced oscillometry is a useful tool for the assessment or exclusion of airflow obstruction in patients with neuromuscular disorders when plethysmography is difficult to perform and forced expiratory flow-volume data reflect muscle weakness rather than airflow limitation.
authors.affiliation: Department of Pulmonary Disease, University Hospital, Maastricht, The Netherlands.
authors.forename: G
authors.initials: G
authors.lastname: Wesseling
authors.forename: F C
authors.initials: FC
authors.lastname: Quaedvlieg
authors.forename: E F
authors.initials: EF
authors.lastname: Wouters
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000403:Airway Resistance / Q000502:physiology; D002648:Child; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D005652:Functional Residual Capacity / Q000502:physiology; D006801:Humans; D007320:Inspiratory Capacity / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009468:Neuromuscular Diseases / Q000503:physiopathology*; D009991:Oscillometry; D011312:Pressure; D012123:Pulmonary Ventilation / Q000502:physiology; D012115:Residual Volume / Q000502:physiology; D015656:Respiratory Mechanics / Q000502:physiology*; D014109:Total Lung Capacity / Q000502:physiology; D014797:Vital Capacity / Q000502:physiology