Increased sensitivity of guinea pig gallbladder in vitro to bradykinin.
Bradykinin evoked concentration dependent contractions of guinea pig gallbladder smooth muscle strips in vitro. Responses to kinins increase over three hours of incubation. Induction of a B1-mediated action, waning activity of endogenous kininase(s) and involvement of eicosanoids as mediators have been investigated as potential contributing mechanisms to the four-fold, time dependent increase in response of this tissue to bradykinin.
Woods
M
M
Department of Pharmacology, University College Dublin, Ireland.
Baird
A W
AW
D000818:Animals; D001920:Bradykinin / Q000031:analogs & derivatives / Q000494:pharmacology*; D002217:Carbachol / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology; D005704:Gallbladder / Q000187:drug effects / Q000502:physiology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007213:Indomethacin; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D010894:Piroxicam / Q000494:pharmacology; D011480:Protease Inhibitors / Q000494:pharmacology; D013997:Time Factors
D011480:Protease Inhibitors; D010894:Piroxicam; C024626:bradykinin, des-Arg(9)-; D002217:Carbachol; D003513:Cycloheximide; D001920:Bradykinin; D007213:Indomethacin