title: Efficacy of engineering controls in reducing occupational exposure to aerosolized pentamidine.
abstract: Aerosolized pentamidine administration may pose potential risks to health care workers exposed to fugitive drug and to infectious respiratory pathogens (eg, tuberculosis) generated by pentamidine-induced cough. Classic infection control methods may be applied to this problem, although the effectiveness of these measures in mitigating environmental pentamidine exposure is unknown. Lack of data fully characterizing pentamidine's mechanism of action or potential mutagenicity, carcinogenicity, or teratogenicity raises concern and suggests worker exposed and environmental contamination be minimized. We report herein on the efficacy of an aerosol containment hood in containing fugitive pentamidine aerosol during administration.
authors.affiliation: Johns Hopkins Medical Institutions, Baltimore.
authors.forename: M A
authors.initials: MA
authors.lastname: McDiarmid
authors.forename: J
authors.initials: J
authors.lastname: Schaefer
authors.forename: C L
authors.initials: CL
authors.lastname: Richard
authors.forename: R E
authors.initials: RE
authors.lastname: Chaisson
authors.forename: B S
authors.initials: BS
authors.lastname: Tepper
mesh_terms: D000336:Aerosols; D000395:Air Pollutants, Occupational / Q000032:analysis; D000397:Air Pollution / Q000517:prevention & control*; D001698:Biomedical Engineering / Q000379:methods*; D004779:Environment Design; D004780:Environment, Controlled; D006282:Health Personnel; D006801:Humans; D016273:Occupational Exposure; D010419:Pentamidine / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use*; D014691:Ventilation
chemical_list: D000336:Aerosols; D000395:Air Pollutants, Occupational; D010419:Pentamidine