Combination therapy of parkinsonism with deprenyl.
In view of the encouraging results in various trials with deprenyl as an added drug therapy for Parkinson's disease, a pilot study to study deprenyl's efficacy in the Indian population was undertaken. Eleven patients were recruited in this open trial and were objectively assessed by Unified Rating Scale for Parkinsonism of Columbia University, Modified Hoehn and Yahr Staging and Schwab and England activities of daily living. Side effects, mood changes, changes in dyskinesia percentage, early morning dystonia and off period percentage were also noted. This study suggests improvement in the above parameters with minimal side effects.
Behari
M
M
Department of Neurology, All India Institute of Medical Sciences, New Delhi.
Ahuja
G K
GK
Singh
K
K
Prasad
K
K
D000328:Adult; D000368:Aged; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007194:India; D007980:Levodopa / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination / Q000187:drug effects; D010300:Parkinson Disease / Q000175:diagnosis / Q000188:drug therapy*; D010865:Pilot Projects; D012642:Selegiline / Q000008:administration & dosage*
D012642:Selegiline; D007980:Levodopa