Antigen-mediated effects on epithelial function.
In summary, immediate hypersensitivity reactions to luminal antigens occur in the intestine and result in pathophysiology including increased permeability and ion secretion. The mechanism involves activation of mast cells with neural amplification (FIG. 5). Released mediators/neurotransmitters may act independently or synergistically on the epithelium to elicit Cl ion secretion. In addition, a cyclooxygenase product of arachidonic acid metabolism, possibly of mesenchymal cell origin, may be a common mediator. However, additional effector cell(s) besides mast cells are undoubtedly involved. This system demonstrates undeniably the concept of neuro-immuno-physiology of gut mucosa.
Perdue
M H
MH
Intestinal Disease Research Unit, McMaster University, Hamilton, Ontario, Canada.
Kosecka
U
U
Crowe
S
S
D000818:Animals; D000941:Antigens / Q000276:immunology*; D004848:Epithelium / Q000502:physiology; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology / Q000502:physiology*; D008407:Mast Cells / Q000502:physiology; D010539:Permeability
D000941:Antigens