Curative effects of all-trans-retinoic acid on rat sarcomas.
The effects of all-trans-retinoic acid (all-trans-RA) on benzo(a)pyrene [B(a)P]-induced malignant sarcomas in Sprague-Dawley female rats were evaluated. Ninety-eight days after B(a)P administration, all-trans-RA was daily injected to animals with or without clinically palpable tumors. The growth of tumors was slowed down compared with controls. Magnetic resonance imaging analyses showed that all-trans-RA-treated rat tumors presented early necrotic areas. Animal survival was slightly increased. Anti-phosphatidylinositol autoantibody levels which were significantly higher in B(a)P-treated rat sera were not modified by all-trans-RA treatment.
Faiderbe
S
S
Laboratoire d'Immunologie et de Pathologie, Université de Bordeaux II, France.
Chagnaud
J L
JL
De Seze
R
R
Geffard
M
M
D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D001323:Autoantibodies; D001564:Benzo(a)pyrene; D002455:Cell Division / Q000187:drug effects; D004195:Disease Models, Animal; D005260:Female; D008279:Magnetic Resonance Imaging; D010716:Phosphatidylinositols / Q000276:immunology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000276:immunology / Q000628:therapy*; D013954:Thyroglobulin; D014212:Tretinoin / Q000627:therapeutic use*
D016588:Anticarcinogenic Agents; D001323:Autoantibodies; D010716:Phosphatidylinositols; D001564:Benzo(a)pyrene; D014212:Tretinoin; D013954:Thyroglobulin