Neuroprotective effects of phencyclidine on acute cerebral ischemia and reperfusion injury of rabbits.
Acute cerebral ischemia and reperfusion injury of rabbits was produced by permanently occluding the vertebral arteries and temporarily clamping the common carotid arteries for 30 min. Phencyclidine [1-(phenylcyclohexyl)piperidine, PCP] 40-80 micrograms.kg-1 icv 30 min before ischemia significantly attenuated the decrease of the total power of electroencephalogram (EEG) within 30 min of ischemia and improved the recovery of brain electric activity following reperfusion. PCP 20-80 micrograms.kg-1 dose-dependently suppressed the creatine kinase (CK) release during cerebral ischemia and reperfusion, and PCP 40-80 micrograms.kg-1 reduced brain ischemic damage. These improvements indicated that PCP has protective effects on acute cerebral ischemia and reperfusion injury.
Lu
Y F
YF
Department of Neurobiology, Shanghai Medical University, China.
Xing
Y Z
YZ
Pan
B S
BS
Li
K Y
KY
Sun
F Y
FY
Zhang
A Z
AZ
D000818:Animals; D002545:Brain Ischemia / Q000134:cerebrospinal fluid / Q000503:physiopathology / Q000517:prevention & control*; D003402:Creatine Kinase / Q000134:cerebrospinal fluid; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D007770:L-Lactate Dehydrogenase / Q000134:cerebrospinal fluid; D008297:Male; D009474:Neurons / Q000187:drug effects; D010622:Phencyclidine / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits; D015427:Reperfusion Injury / Q000134:cerebrospinal fluid / Q000503:physiopathology / Q000517:prevention & control*
D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; D010622:Phencyclidine