title: A double-blind, placebo-controlled study of the effect of imipramine on TRH-induced urinary urgency in healthy men.
abstract: We studied the effect of imipramine (IMI) on thyroid releasing hormone (TRH)-induced urinary urgency as a way of investigating the mechanism of the beneficial effect of IMI on enuresis. In a double-blind study, 12 normal, healthy men between 21 and 39 yr of age ranked their urge to urinate at 30-sec intervals following IV injection of TRH (500 micrograms) or saline. The subjects then were randomly assigned to either IMI (1 mg/kg) or placebo groups for 10 days, and the procedure was repeated. Compared to saline, TRH produced a significant elevation in urinary urgency in all subjects. IMI did not significantly blunt TRH-induced urinary urgency. Thus, the mechanism by which IMI affects enuresis is likely not mediated at the level of the urinary urgency induced by TRH.
authors.affiliation: University of Michigan Medical Center, Child and Adolescent Psychiatric Hospital, Ann Arbor 48109-0290.
authors.forename: N E
authors.initials: NE
authors.lastname: Alessi
authors.forename: C D
authors.initials: CD
authors.lastname: Knight
authors.forename: J T
authors.initials: JT
authors.lastname: Bergs
authors.forename: S J
authors.initials: SJ
authors.lastname: Eisner
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004775:Enuresis / Q000503:physiopathology; D006801:Humans; D007099:Imipramine / Q000494:pharmacology*; D008297:Male; D016037:Single-Blind Method; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone / Q000502:physiology; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014554:Urination / Q000187:drug effects* / Q000502:physiology; D014563:Urodynamics / Q000187:drug effects* / Q000502:physiology
chemical_list: D014284:Triiodothyronine; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D007099:Imipramine; D013974:Thyroxine