title: The kallikrein-kinin system in cardiac tissue.
abstract: Kallikrein and minute amounts of kininogen have been found in rat cardiac tissue. The mRNA for kallikrein was also determined by the polymerase chain reaction using KK-specific probe. The existence of an intrinsic kallikrein-kinin system in the heart raises the possibility that the enzyme-peptide system is involved in local regulation of cardiac function and metabolism.
authors.affiliation: Hypertension and Vascular Res. Div., Henry Ford Hospital, Detroit, MI.
authors.forename: H L
authors.initials: HL
authors.lastname: Nolly
authors.forename: G
authors.initials: G
authors.lastname: Saed
authors.forename: G
authors.initials: G
authors.lastname: Scicli
authors.forename: O A
authors.initials: OA
authors.lastname: Carretero
authors.forename: A G
authors.initials: AG
authors.lastname: Scicli
mesh_terms: D000818:Animals; D000906:Antibodies; D015152:Blotting, Northern; D002846:Chromatography, Affinity; D002850:Chromatography, Gel; D015342:DNA Probes; D004789:Enzyme Activation; D066298:In Vitro Techniques; D007610:Kallikreins / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D007700:Kinetics; D007704:Kininogens / Q000032:analysis / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014357:Trypsin / Q000378:metabolism
chemical_list: D000906:Antibodies; D015342:DNA Probes; D007704:Kininogens; D012333:RNA, Messenger; D007610:Kallikreins; D014357:Trypsin