Indonesia medicinal plants. III. On the constituents of the bark of Fagara rhetza (Rutaceae). (1): Alkaloids, phenylpropanoids, and acid amide.
Two new phenylpropanoids, named O-geranylsinapyl alcohol (1) and O-geranylconiferyl alcohol (2), and a new acid amide, named hazeleamide (3), were isolated from the bark of Fagara rhetza (Rutaceae), an Indonesian medicinal plant from Flores Island, Indonesia. The chemical structures of 1, 2, and 3 have been elucidated on the basis of their chemical and physicochemical properties. Among the three new compounds, hazeleamide (3) was found to show a pungent taste and to exert a moderate antimalarial activity in an in vitro test system.
Shibuya
H
H
Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Takeda
Y
Y
Zhang
R
R
Tong
R X
RX
Kitagawa
I
I
D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000577:Amides / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification* / Q000494:pharmacology; D005231:Fatty Acids, Unsaturated / Q000302:isolation & purification* / Q000494:pharmacology; D007214:Indonesia; D010636:Phenols / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D053284:Polyunsaturated Alkamides
D000470:Alkaloids; D000577:Amides; D000962:Antimalarials; D005231:Fatty Acids, Unsaturated; D010636:Phenols; D053284:Polyunsaturated Alkamides; C078301:O-geranylconiferyl alcohol; C078302:O-geranylsinapyl alcohol; C078303:hazaleamide