[Changes in malondialdehyde contents in serum and tissues after ischemia and reperfusion of the bowel in dogs].
The portal circulation was reduced to 50% for one hour by partially occluding the superior mesenteric artery, and the relationship between the changes in malondialdehyde (MDA) and multiple organ damage was studied. The results showed that there was a marked change in hepatic enzymology, with MDA values significantly elevated in serum and lung and liver tissues after the reperfusion when compared with controls. These results suggested that lipid peroxidation initiated by free oxygen radicals played an important role in the multiple organ damages, and the extent of organ damage was closely correlated with the contents of MDA in tissues.
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Trauma Center, 304th Hospital of PLA.
D000818:Animals; D004285:Dogs; D005260:Female; D007422:Intestines / Q000098:blood supply; D007511:Ischemia / Q000378:metabolism; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism*; D015427:Reperfusion Injury / Q000378:metabolism*
D008315:Malondialdehyde