Solid and papillary neoplasm of the pancreas.
In two cases of solid and papillary neoplasm of the pancreas (SPN), positive staining for argyrophil granules, chromogranin-A, neuron-specific enolase, chymotrypsin, alpha 1-antitrypsin, vimentin, cytokeratin, and estrogen receptors was present. Ultrastructurally, neurosecretory as well as zymogenlike granules were demonstrated. Measurements of mean nuclear volume and volume-corrected mitotic index discriminated between SPN and well-differentiated ductal adenocarcinoma of the pancreas, with notably lower values being seen in SPN. Silver-stained nucleolar organizer region counts showed wide overlaps. The results suggest that SPN is a tumor with mixed endocrine and exocrine features. Its low malignant potential compared to ductal adenocarcinoma is reflected in the mean nuclear volume and volume-corrected mitotic index. The presence of estrogen receptors may prove therapeutically useful.
Jørgensen
L J
LJ
Department of Pathology and Surgical Gastroenterology, Hvidovre Hospital, Denmark.
Hansen
A B
AB
Burcharth
F
F
Philipsen
E
E
Horn
T
T
D000293:Adolescent; D000328:Adult; D002918:Chymotrypsin / Q000032:analysis; D004268:DNA-Binding Proteins / Q000032:analysis; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D010751:Phosphopyruvate Hydratase / Q000032:analysis
D004268:DNA-Binding Proteins; C068169:alpha 1-antitrypsin binding protein 1; D002918:Chymotrypsin; D010751:Phosphopyruvate Hydratase