Characterization of a 28-kD polymorphic polypeptide detected by two-dimensional electrophoresis of human platelets.
A genetic polymorphism of a human platelet polypeptide with a molecular weight of 28 kD detected by two-dimensional electrophoresis was investigated in family and population studies, and cell distribution. The 28-kD polypeptide showed autosomal codominant inheritance of two alleles. The gene frequencies of the two alleles were 0.925 and 0.075, respectively. The 28-kD polypeptide was observed in lymphocytes, neutrophils, eosinophils and monocytes, in addition to platelets. This polypeptide showed good reproducibility in electrophoresis, and appears to be useful as a genetic marker of the human genome in gene mapping and pedigree analysis.
Iwamoto
S
S
Department of Legal Medicine and Human Genetics, Jichi Medical School, Tochigi, Japan.
Kajii
E
E
Omi
T
T
Tsuchida
S
S
Ikemoto
S
S
D001792:Blood Platelets / Q000737:chemistry*; D001798:Blood Proteins / Q000032:analysis / Q000235:genetics; D015180:Electrophoresis, Gel, Two-Dimensional; D005260:Female; D006801:Humans; D008297:Male; D010375:Pedigree; D010455:Peptides / Q000097:blood* / Q000235:genetics; D010641:Phenotype; D011110:Polymorphism, Genetic
D001798:Blood Proteins; D010455:Peptides