Insulin modulation of chronotropic response to Adrenaline in diabetic dogs.
In 8 unanesthetized dogs, 10-21 days post pancreatectomy, the cardiac chronotropic response to rapid infusion of a pharmacological dosage of Adrenaline was begun. During the subsequent month, the response was recorded electrocardiographically on 19 occasions. On 8 occasions, animals were treated with continuous intravenous administration of fluids and insulin up to the time of the test; on 11, insulin was omitted for 18 hours before Adrenaline injection. Insulin treated animals responded with the typical brief initial bradycardia, followed by some 2 minutes of ventricular tachycardia, and restoration of preinjection heart rate and electrocardiograph pattern within 5 minutes. On those occasions when insulin was omitted, the tachycardia was replaced by ventricular bradycardia. The altered chronotropic response of non-insulin treated dogs indicates impairment of their cardiac beta receptors.
Hiatt
N
N
Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California.
Hiatt
J R
JR
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000503:physiopathology*; D004285:Dogs; D004562:Electrocardiography; D004837:Epinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D007328:Insulin / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D010180:Pancreatectomy; D013268:Stimulation, Chemical
D001786:Blood Glucose; D007328:Insulin; D004837:Epinephrine