title: Copper supplementation in the rat: preliminary observations on the clinical, hematological and histopathological profile.
abstract: Complete toxicological examinations in female rats fed an "anti-inflammatory" 200 ppm copper-containing diet for 30 and 58 days were performed. Copper was found to accumulate in liver, kidneys and paws; however, at the hematological, clinical chemical and histopathological levels, this treatment did not seem able to induce any toxic accumulation phenomenon in the examined rats.
authors.affiliation: Laboratorio di Patologia, Università degli Studi, Verona, Italia.
authors.forename: P
authors.initials: P
authors.lastname: Cristofori
authors.forename: A
authors.initials: A
authors.lastname: Terron
authors.forename: M
authors.initials: M
authors.lastname: Marella
authors.forename: U
authors.initials: U
authors.lastname: Moretti
authors.forename: M
authors.initials: M
authors.lastname: Pasqualicchio
authors.forename: G P
authors.initials: GP
authors.lastname: Velo
authors.forename: R
authors.initials: R
authors.lastname: Milanino
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001772:Blood Cell Count / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003300:Copper / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D003404:Creatinine / Q000097:blood; D004032:Diet; D005260:Female; D006614:Hindlimb / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000637:Transaminases / Q000097:blood; D014508:Urea / Q000097:blood
chemical_list: D003300:Copper; D014508:Urea; D003404:Creatinine; D000637:Transaminases; D000469:Alkaline Phosphatase