Medullary respiratory neurons in the guinea pig: localization and firing patterns.
The location and firing patterns of medullary respiratory neurons have been described in a small number of species. The cat has been the most widely studied species, but some potentially important differences have recently been noted in others. A more complete survey of species is required to determine the significance of these differences. We describe the location and firing patterns of respiratory neurons in the medulla of anesthetized, paralyzed and mechanically ventilated adult guinea pigs. Extracellular single-unit recordings were made from the medulla, their phase relationship with phrenic nerve activity used to define them as respiratory and their location marked with fast green. Respiratory units were concentrated ventrolateral to the nucleus tractus solitarius (NTS) and within and surrounding the nucleus ambiguus (NA), corresponding to the dorsal respiratory group (DRG) and ventral respiratory group (VRG) of the cat, respectively. Most DRG respiratory units were inspiratory, while the VRG contained equal numbers of inspiratory and expiratory units. The DRG and VRG both contained early, late and constant-frequency inspiratory and expiratory units. In general, these findings are similar to those in other mammalian species examined, consistent with these basic aspects of the respiratory network being highly conserved.
Richerson
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Department of Physiology and Biophysics, University of Iowa, College of Medicine, Iowa City 52242.
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D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001931:Brain Mapping / Q000379:methods; D006168:Guinea Pigs; D008168:Lung / Q000502:physiology; D008526:Medulla Oblongata / Q000033:anatomy & histology* / Q000502:physiology; D009046:Motor Neurons / Q000502:physiology / Q000648:ultrastructure; D009474:Neurons / Q000502:physiology / Q000648:ultrastructure*; D012125:Respiratory Center / Q000033:anatomy & histology* / Q000378:metabolism; D012122:Ventilators, Mechanical