title: Preliminary results of a complete study protocol on synthetic vascular graft healing and its complications.
abstract: The microscopic and anatomic features and bacteriologic culture results of different portions of single, explanted dacron synthetic vascular grafts (SVG) were studied together with patient clinical data. With this complete study protocol a better understanding of the healing process and its associated pathology can be achieved. We studied three, amply distanced graft portions from each of five patients (15 total graft portions) undergoing revision for infectious and non-infectious reasons. We divided the SVG portions studied into a Group 1, with high degrees of graft healing and into a Group 2, with both infection-dependent, early healing complications and perigraft chronic inflammatory reaction-dependent, late healing complications. These late healing complications were found dependent upon a host vs graft reaction. This study confirmed in humans the important role of an internal and external fibrotic graft incorporation in the definitive healing of a SVG. A host vs graft reaction was suggested to be an alternative to the frequently cited low virulent infection pathogenesis of late SVG healing complications. A sure definition and treatment of late SVG healing complications will only be established by means of a complete study protocol performed on a large number of explanted SVGs.
authors.affiliation: Department of Vascular Surgery, University of Rome La Sapienza, Italy.
authors.forename: F
authors.initials: F
authors.lastname: De Santis
authors.forename: F
authors.initials: F
authors.lastname: Speziale
authors.forename: G J
authors.initials: GJ
authors.lastname: Massimi
authors.forename: I
authors.initials: I
authors.lastname: Flaishman
authors.forename: L
authors.initials: L
authors.lastname: Rizzo
authors.forename: C
authors.initials: C
authors.lastname: Santini
authors.forename: V
authors.initials: V
authors.lastname: Petrozza
authors.forename: F
authors.initials: F
authors.lastname: Carpino
authors.forename: P
authors.initials: P
authors.lastname: Fiorani
mesh_terms: D001807:Blood Vessel Prosthesis; D005549:Foreign-Body Reaction / Q000473:pathology* / Q000601:surgery; D006789:Host vs Graft Reaction / Q000502:physiology*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D011093:Polyethylene Terephthalates; D016459:Prosthesis-Related Infections / Q000473:pathology* / Q000601:surgery; D012086:Reoperation; D013203:Staphylococcal Infections / Q000209:etiology / Q000601:surgery; D013212:Staphylococcus epidermidis / Q000302:isolation & purification; D014945:Wound Healing / Q000502:physiology*
chemical_list: D011093:Polyethylene Terephthalates