The mouse as a model for human audition. A review of the literature.
The mouse has several distinct advantages as an experimental model for human audition. Mice and humans express a similar presbyacusic and ototraumatic pattern. Several genetic mouse models also exist for conditions resembling human auditory disorders, such as otosclerosis. This paper reviews the strains of inbred mice (e.g. the CBA/J) which have recently been used as models for the normal human auditory system, describing their deficiencies. It is suggested that the F1 offspring of CBA/CaJ and AU/SsJ inbred mice would have advantages over existing models.
Henry
K R
KR
Department of Psychology, University of California, Davis 95616.
McGinn
M D
MD
D000161:Acoustic Stimulation; D000818:Animals; D005260:Female; D006309:Hearing / Q000502:physiology*; D006311:Hearing Disorders / Q000503:physiopathology; D006801:Humans; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics / Q000502:physiology*; D008954:Models, Biological; D011304:Presbycusis / Q000503:physiopathology