Chymosin: a short review on foetal and neonatal gastric proteases.
All vertebrates in which the age dependent expression of gastric proteases has been investigated show a characteristic developmental pattern. Neonatal proteases which show partial immunochemical identity with calf chymosin have been observed in several species. The amino acid sequence of lamb chymosin shows 94% of identity with that of calf chymosin. Chymosins from pig and cat show about 85% and 75% of identity with calf chymosin. Chicken embryonic pepsinogen appears to be more related to calf chymosin than to other gastric proteases. A pseudo-gene for a chymosin-like protease from man has been identified. But a functional, human chymosin-like neonatal protease has not been identified. The possible physiological significance of chymosin and the clotting of milk are discussed.
Foltmann
B
B
Institute of Biochemical Genetics, University of Copenhagen, Denmark.
D000595:Amino Acid Sequence; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D012085:Chymosin / Q000737:chemistry / Q000378:metabolism; D005333:Fetus / Q000378:metabolism*; D005753:Gastric Mucosa / Q000196:embryology / Q000201:enzymology / Q000254:growth & development; D006801:Humans; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity
D012085:Chymosin