The use of non-steroidal anti-inflammatory drugs for the relief of pain in laboratory rodents and rabbits.
The data concerning the use of non-steroidal anti-inflammatory drugs (NSAIDs) and evidence for their efficacy in laboratory rats and mice are reviewed. This information is then extrapolated to clinical situations and dose rates that take account of ulcerogenic side effects are recommended. NSAIDs have the potential to be a very useful group of analgesics and should always be considered when attempting to provide pain relief in laboratory animals.
Liles
J H
JH
Comparative Biology Centre, Medical School, Newcastle upon Tyne, UK.
Flecknell
P A
PA
D000698:Analgesia / Q000662:veterinary*; D000827:Animal Welfare; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000633:toxicity; D006801:Humans; D051379:Mice; D010146:Pain / Q000517:prevention & control / Q000662:veterinary*; D010147:Pain Measurement; D011817:Rabbits; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal