title: The effect of continuous topical application of heparin on flap survival.
abstract: To evaluate the beneficial effects of heparin on flap survival area, an experimental study was carried out on dorsal flaps in rats. Topical applications of heparin, released from a silicone gel sheet onto the critical area (which generally necrosed without treatment), resulted in an increase in the flap survival area and rate as compared to controls (p < 0.01). When heparin was applied topically but solely to an area proximal to the critical area however, no increase in the survival area resulted.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Hirosaki University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Sawada
authors.forename: I
authors.initials: I
authors.lastname: Hatayama
authors.forename: K
authors.initials: K
authors.lastname: Sone
mesh_terms: D000287:Administration, Topical; D000818:Animals; D005260:Female; D006085:Graft Survival / Q000187:drug effects*; D006493:Heparin / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D015242:Ofloxacin / Q000494:pharmacology; D051381:Rats; D012867:Skin / Q000098:blood supply; D013524:Surgical Flaps
chemical_list: D006493:Heparin; D015242:Ofloxacin