Experimental study on intradermal antitetanus antityphoid immunization.
A new type of concentrated unadsorbed Tetanus vaccine was administered in animals by intradermal route, associated or not with Typhoid vaccine. The results of the laboratory tests demonstrated that this vaccine is innocuous and produces minimal reactions. A single doses of Tetanus vaccine inoculated in guinea pig or rabbit resulted in a relevant titer which increased when the Typhoid vaccine was associated. Also, in such immunized guinea pigs, a remarkable resistance to tetanic toxin was achieved. The levels of the active or passive typhoid-protective power as well as that of the agglutinating antibodies were not influenced by the association of the Tetanus vaccine to the Typhoid vaccine. Therefore, when the Typhoid vaccine suspended in Tetanus vaccine was administered intradermally to the animals by Jet injector, it had not a negative effect for none of the two components, had a beneficial effect upon the levels of determined antibody production and allowed an easier and more rapid administration of these vaccines.
Dimache
G
G
Cantacuzino Institute, Bucharest, Romania.
Stoean
C
C
Durbacă
S
S
Laşcu
N
N
Croitoru
M
M
Dimache
A
A
D000373:Agglutinins / Q000096:biosynthesis; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D002642:Chick Embryo; D003017:Clostridium tetani / Q000276:immunology; D004338:Drug Combinations; D006168:Guinea Pigs; D007271:Injections, Intradermal; D008297:Male; D051379:Mice; D011817:Rabbits; D012485:Salmonella typhi / Q000276:immunology; D013742:Tetanus / Q000517:prevention & control; D013744:Tetanus Toxin / Q000633:toxicity; D013745:Tetanus Toxoid / Q000008:administration & dosage* / Q000633:toxicity; D014435:Typhoid Fever / Q000517:prevention & control; D014436:Typhoid-Paratyphoid Vaccines / Q000008:administration & dosage* / Q000633:toxicity; D014611:Vaccination
D000373:Agglutinins; D000907:Antibodies, Bacterial; D004338:Drug Combinations; D013744:Tetanus Toxin; D013745:Tetanus Toxoid; D014436:Typhoid-Paratyphoid Vaccines