The use of intranasal anticholinergic agents in the treatment of nonallergic perennial rhinitis.
Nonallergic perennial rhinitis is a heterogenous disorder. Although the underlying cause is unknown, there is evidence of an autonomic imbalance with parasympathetic hyperreactivity in affected persons. We review this evidence and the role of ipratropium bromide, an anticholinergic drug with topical activity, in the management of nonallergic perennial rhinitis. The pharmacologic features, safety, and efficacy of ipratropium bromide are reviewed.
Borts
M R
MR
Division of Allergy and Immunology, St. Louis University School of Medicine, MO 63104-1028.
Druce
H M
HM
D000281:Administration, Intranasal; D006801:Humans; D009241:Ipratropium / Q000008:administration & dosage / Q000494:pharmacology; D009299:Nasal Provocation Tests; D010276:Parasympatholytics / Q000008:administration & dosage*; D012220:Rhinitis / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology
D010276:Parasympatholytics; D009241:Ipratropium