title: [Characteristics of pharmacokinetics of liposome-incorporated rifampicin in rats after intratracheal administration].
abstract: Pharmacokinetics of rifampicin after its single intratracheal administration in the form of the liposome-encapsulated drug and its aqueous solution was studied on rats. It was shown that after the exposure to the liposome-incorporated rifampicin (10 mg/kg) the concentration-time curve in the blood and lungs was sigmoid with the retarded decrease in the blood drug concentration within 9 hours. The plateau segment of the curve provided at least a 4-fold longer maintenance of the rifampicin concentration in the blood and lungs at 3 to 4 micrograms/ml. The use of the liposome-incorporated antibiotic induced 2- and 1.5-fold increases in the AUC in regard to the lungs and blood, respectively.
authors.forename: G L
authors.initials: GL
authors.lastname: Gurevich
authors.forename: L N
authors.initials: LN
authors.lastname: Berezovskaia
authors.forename: K K
authors.initials: KK
authors.lastname: Manuĭlov
mesh_terms: D000818:Animals; D002406:Catheterization, Peripheral; D004337:Drug Carriers; D008081:Liposomes; D008099:Liver / Q000378:metabolism*; D008168:Lung / Q000378:metabolism*; D008954:Models, Biological; D051381:Rats; D012293:Rifampin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors; D014132:Trachea / Q000187:drug effects
chemical_list: D004337:Drug Carriers; D008081:Liposomes; C032393:25-deacetylrifampicin; D012293:Rifampin
vernacular_title: Osobennosti farmakokinetiki rifampitsina, vkliuchennogo v liposomy, u krys pri vnutritrakheal'nom vvedenii.