Cisplatin and platinum analogues: recent advances.
Cisplatin is a critically important antineoplastic agent employed in treating patients who have a broad spectrum of neoplasms. Resistance to this agent poses a serious clinical dilemma. The objective of this review is to summarize the principal mechanisms that contribute to cytotoxicity by this agent and underlie resistance. Knowledge of these processes provides a rational basis for developing therapeutic strategies to circumvent resistance.
Fram
R J
RJ
Department of Medicine, Brockton/W. Roxbury VAMC, MA 02401.
D000818:Animals; D002945:Cisplatin / Q000494:pharmacology* / Q000627:therapeutic use; D004247:DNA / Q000187:drug effects / Q000378:metabolism; D004249:DNA Damage; D004351:Drug Resistance; D006801:Humans
D004247:DNA; D002945:Cisplatin