title: Transmission blocking antibody of the Plasmodium falciparum zygote/ookinete surface protein Pfs25 also influences sporozoite development.
abstract: The Plasmodium falciparum zygote/ookinete surface protein, Pfs25, persists in the oocyst wall throughout its development. Anti-25 kD transmission blocking antibody, given to infected Anopheles stephensi or A. gambiae mosquitoes in an additional bloodmeal, 3-6 days after being fed gametocyte infected blood, penetrated the oocyst and reacted with the 25 kD protein within it. This reaction caused a significant reduction in the number of developing sporozoites. Mouse serum containing antibodies raised by immunization with a recombinant 25 kD yeast product showed a similar effect.
authors.affiliation: Department of Parasitology, University of Nijmegen, The Netherlands.
authors.forename: A H
authors.initials: AH
authors.lastname: Lensen
authors.forename: G J
authors.initials: GJ
authors.lastname: Van Gemert
authors.forename: M G
authors.initials: MG
authors.lastname: Bolmer
authors.forename: J F
authors.initials: JF
authors.lastname: Meis
authors.forename: D
authors.initials: D
authors.lastname: Kaslow
authors.forename: J H
authors.initials: JH
authors.lastname: Meuwissen
authors.forename: T
authors.initials: T
authors.lastname: Ponnudurai
mesh_terms: D000818:Animals; D000852:Anopheles / Q000469:parasitology; D000913:Antibodies, Protozoan / Q000008:administration & dosage; D000953:Antigens, Protozoan; D000954:Antigens, Surface; D016782:Apicomplexa / Q000254:growth & development / Q000276:immunology / Q000648:ultrastructure; D001667:Binding, Competitive; D007114:Immunization; D051379:Mice; D010963:Plasmodium falciparum / Q000276:immunology*; D015800:Protozoan Proteins / Q000276:immunology; D011994:Recombinant Proteins / Q000276:immunology
chemical_list: D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D000954:Antigens, Surface; C071284:Pfs25 protein, Plasmodium falciparum; D015800:Protozoan Proteins; D011994:Recombinant Proteins