Cyclosporine interactions with miconazole and other azole-antimycotics: a case report and review of the literature.
Several antimicrobial drugs have been shown to pharmacokinetically interact with cyclosporine. On two separate occasions, we observed increases in cyclosporine plasma concentrations during concomitant miconazole therapy in a heart transplant patient with an infection secondary to Pseudallescheria boydii. To our knowledge, no interaction between cyclosporine and miconazole has previously been reported. In addition, drug interactions were observed between cyclosporine and ketoconazole and possibly between cyclosporine and SCH 39304, an investigational azole-antifungal agent. No interaction was noted between cyclosporine and fluconazole. In general, clinicians should anticipate drug interactions between cyclosporine and azole-antimycotic agents.
Horton
C M
CM
Department of Pharmacy Practice, College of Pharmacy, University of Arizona, Tucson 85721.
Freeman
C D
CD
Nolan
P E
PE
Copeland
J G
JG
D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016572:Cyclosporine / Q000493:pharmacokinetics / Q000494:pharmacology*; D004347:Drug Interactions; D016027:Heart Transplantation; D006801:Humans; D007165:Immunosuppression Therapy; D007654:Ketoconazole / Q000494:pharmacology; D008172:Lung Diseases, Fungal / Q000188:drug therapy / Q000382:microbiology; D008297:Male; D008825:Miconazole / Q000494:pharmacology* / Q000627:therapeutic use; D008875:Middle Aged; D011541:Pseudallescheria; D014230:Triazoles / Q000494:pharmacology
D000935:Antifungal Agents; D014230:Triazoles; C056513:Sch 39304; D008825:Miconazole; D016572:Cyclosporine; D007654:Ketoconazole