title: 85Sr uptake by the chick embryonic heart: effect of high doses of isoproterenol.
abstract: The aim of the present study was to establish whether intraamnial administration of toxic doses of isoproterenol to chick embryos increases cardiac accumulation of strontium, the homologue element of calcium. It has been shown that the ability of embryonic tissues (blood, heart, and liver) to accumulate 85Sr decreases significantly during ontogeny. Administration of isoproterenol to chick embryos did not elevate the concentration of 85Sr in the heart. It seems, therefore, that isoproterenol-induced developmental changes in the chick embryonic myocardium are not necessarily due to intracellular calcium (as measured by 85Sr) overload.
authors.affiliation: Institute of Physiology, Czechoslovak Academy of Sciences, Prague.
authors.forename: I
authors.initials: I
authors.lastname: Ostádalová
authors.forename: B
authors.initials: B
authors.lastname: Ostádal
mesh_terms: D000818:Animals; D002642:Chick Embryo; D006321:Heart / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism*; D009929:Organ Size / Q000187:drug effects; D013326:Strontium Radioisotopes
chemical_list: D013326:Strontium Radioisotopes; D007545:Isoproterenol