title: Urea synthesis in rats fed diet containing kidney beans.
abstract: When rats were fed a diet containing kidney bean (Phaesolus vulgaris) urea excretion was increased 3-5 fold. Isolated liver mitochondria from rats fed the kidney bean diet produced 40% more citrulline in the presence of arginine than mitochondria isolated from control rats. Mitochondrial activities of urea cycle enzymes and N-acetylglutamate synthetase were similar in animals fed diets containing kidney bean or lactalbumin. The possible mechanisms causing acute urea production in rats fed with kidney bean are discussed.
authors.affiliation: Rowett Research Institute, Aberdeen, Scotland.
authors.forename: P W
authors.initials: PW
authors.lastname: Scislowski
authors.forename: G
authors.initials: G
authors.lastname: Grant
authors.forename: I
authors.initials: I
authors.lastname: Harris
authors.forename: K
authors.initials: K
authors.lastname: Pickard
authors.forename: A
authors.initials: A
authors.lastname: Pusztai
mesh_terms: D000123:Acetyltransferases / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism; D051046:Amino-Acid N-Acetyltransferase; D000818:Animals; D002956:Citrulline / Q000096:biosynthesis; D003401:Creatine / Q000652:urine; D004032:Diet / Q000009:adverse effects*; D007887:Fabaceae; D066298:In Vitro Techniques; D007768:Lactalbumin; D008930:Mitochondria, Liver / Q000378:metabolism; D010946:Plants, Medicinal; D051381:Rats; D014508:Urea / Q000378:metabolism* / Q000652:urine
chemical_list: D000596:Amino Acids; D002956:Citrulline; D014508:Urea; D007768:Lactalbumin; D000123:Acetyltransferases; D051046:Amino-Acid N-Acetyltransferase; D003401:Creatine