title: Capsular types of Streptococcus pneumoniae isolated from blood and CSF during 1982-1987.
abstract: Knowledge about the type distribution of Streptococcus pneumoniae is fundamental to ensure an effective formulation of pneumococcal vaccine, especially with the possibility of producing a polysaccharide-protein-conjugated vaccine for the prevention of invasive disease in children. During the 6-year period 1982-1987, we received and typed 10,298 isolates from patients with invasive pneumococcal disease: 7,812 (76%) from blood and 2,486 (24%) from CSF. Of all isolates, 81% were recovered from individuals in Europe and 23% were from children. In order of frequency, S. pneumoniae types 6A + 6B, 14, 18C, 19F, 1, 7F, 23F, 19A, 4, and 5 were most commonly isolated from children, and types 3, 1, 14, 7F, 4, 6A + 6B, 8, 23F, 9V, and 19F, from adults. The pneumococcal types in the currently available 23-valent vaccine represented 87% of all isolates in this study, but the proportion of vaccine types varied somewhat with age and source. In all pneumococcal groups included in the vaccine, the vaccine types represented > 80% of the isolates, except in groups 6, 15, and 18.
authors.affiliation: World Health Organization Collaborating Centre for Reference and Research on Pneumococci, Statens Seruminstitut, Copenhagen, Denmark.
authors.forename: S V
authors.initials: SV
authors.lastname: Nielsen
authors.forename: J
authors.initials: J
authors.lastname: Henrichsen
mesh_terms: D000328:Adult; D016667:Bacterial Capsules / Q000097:blood / Q000134:cerebrospinal fluid / Q000145:classification / Q000276:immunology; D001428:Bacterial Vaccines / Q000138:chemical synthesis*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D011008:Pneumococcal Infections / Q000276:immunology / Q000382:microbiology* / Q000517:prevention & control; D011135:Polysaccharides, Bacterial / Q000737:chemistry / Q000145:classification* / Q000276:immunology / Q000302:isolation & purification; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification / Q000276:immunology*
chemical_list: D001428:Bacterial Vaccines; D011135:Polysaccharides, Bacterial