Ivermectin and diethylcarbamazine trials in leaf monkeys (Presbytis cristatus) infected with Wuchereria kalimantani.
Clinical trials of Ivermectin in single oral doses of 200, 400, and 1,000 mg/kg body weight or in multiple doses of 200 mg/kg body weight for 5 consecutive days were performed in leaf monkeys (Presbytis cristatus) infected with Wuchereria kalimantani. Optimal microfilaricidal effect occurred at 200 mg/kg body weight. The drug was less effective than diethylcarbamazine in this animal model for human filariasis but had no adverse effects.
Kurniawan
A
A
Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta.
Sartono
E
E
Setiowati
W E
WE
Supali
T
T
Wibowo
H
H
Purnomo
Rukmono
B
B
Partono
F
F
D000818:Animals; D002520:Cercopithecidae; D004049:Diethylcarbamazine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000882:Haplorhini; D007559:Ivermectin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008842:Microfilariae; D010272:Parasitic Diseases / Q000188:drug therapy*; D010919:Placebos; D014957:Wuchereria / Q000187:drug effects*
D010919:Placebos; D007559:Ivermectin; D004049:Diethylcarbamazine