Synaptophysin expression in "ependymal tumors" induced by ethyl-nitrosourea in rats.
Synaptophysin expression was studied in seven "ependymomas" induced by transplacental administration of ethyl-nitrosourea in rats. In all the cases, strong positivity for synaptophysin was found on tumor cells. This finding supports previous studies suggesting that ENU-induced brain tumors considered to be ependymal neoplasms, are, in fact, primitive neuroectodermal tumors.
Vaquero
J
J
Neurosurgical Department, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain.
Coca
S
S
Zurita
M
M
Oya
S
S
Arias
A
A
Moreno
M
M
Morales
C
C
D000818:Animals; D001932:Brain Neoplasms / Q000139:chemically induced* / Q000737:chemistry*; D004805:Ependyma / Q000737:chemistry / Q000473:pathology; D004806:Ependymoma / Q000139:chemically induced* / Q000737:chemistry*; D005038:Ethylnitrosourea; D005260:Female; D007150:Immunohistochemistry; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D016708:Synaptophysin / Q000032:analysis*
D016708:Synaptophysin; D005038:Ethylnitrosourea