Effects of a human urinary kininogenase (SK-827) on cerebral microcirculation after glass bead-induced cerebral embolism in rabbits.
The pharmacological effects of a human urinary kininogenase (SK-827) on the cerebral microcirculation were studied intravital-microscopically in a rabbit with cerebral microvessel injury induced by glass bead injection into an internal carotid artery. Intravenous administration of SK-827 dilated pial arteries of the brain and increased cerebral hemoglobin content (IHb). SK-827 tended to dilate smaller arterioles more markedly than larger arterioles, and larger arterioles than small arteries. SK-827 appeared to have a vasodilating effects qualitatively different from those of nicardipine and CDP-choline. Findings obtained by concurrent hematological and biochemical examinations also suggested its beneficial effects on the function of platelets and erythrocytes.
Nagano
H
H
Kumamoto Research Laboratory, Sanwa Kagaku Kenkyusho Co., Ltd., Japan.
Suzuki
T
T
Hayashi
M
M
Asano
M
M
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000818:Animals; D001160:Arterioles / Q000187:drug effects; D002536:Cerebral Arteries / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003566:Cytidine Diphosphate Choline / Q000494:pharmacology / Q000627:therapeutic use; D005898:Glass; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007269:Injections, Intra-Arterial; D002542:Intracranial Embolism and Thrombosis / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D016234:Kallikrein-Kinin System / Q000187:drug effects*; D007610:Kallikreins / Q000494:pharmacology / Q000627:therapeutic use*; D008833:Microcirculation / Q000187:drug effects; D008863:Microspheres; D009529:Nicardipine / Q000494:pharmacology / Q000627:therapeutic use; D011817:Rabbits; D013929:Thromboxane B2 / Q000097:blood; D014556:Urine / Q000737:chemistry; D014665:Vasodilator Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*
D006454:Hemoglobins; D014665:Vasodilator Agents; D003566:Cytidine Diphosphate Choline; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D009529:Nicardipine; D007610:Kallikreins