Pharmacokinetics of carprofen administered intravenously to sheep.
Carprofen was administered intravenously to sheep at two dose rates (0.7 and 4.0 mg kg-1), and the pharmacokinetics of the drug studied. Plasma concentrations of the drug were measured by high performance liquid chromatography. Carprofen had a small volume of distribution (Vd[area], 95.5 and 118.4 ml kg-1), a prolonged elimination half-life (t1/2 beta, 26.1 and 33.7 hours) and a slow body clearance rate (Clb, 2.5 ml kg-1 h-1) in sheep.
Welsh
E M
EM
Department of Veterinary Pharmacology, University of Glasgow Veterinary School, Bearsden.
Baxter
P
P
Nolan
A M
AM
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002227:Carbazoles / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007275:Injections, Intravenous / Q000662:veterinary; D012756:Sheep / Q000378:metabolism*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002227:Carbazoles; C007005:carprofen