Long-term suppression of the development of complementary memory storage sites in mice: functional interdependence of acetylcholine and dopamine.
Bitemporal injections of puromycin consistently induce amnesia of aversive maze learning in mice when given within 3 days after training. These injections consistently fail to induce amnesia when given 6 or more days after training. Consistent with the evidence from other laboratories, we interpret these results to indicate that the initial, temporal memory storage sites are supplemented 6 days after training by the development of complementary storage sites in other cerebral areas. Previous experiments have shown that this process is suppressed for 30-60 days by a single SC injection of scopolamine, a muscarinic antagonist. We now find that this suppressive action of scopolamine can be completely nullified by haloperidol, a dopaminergic antagonist. This finding supports the view that there may be a therapeutic role for dopamine antagonists in the treatment of cognitive dysfunction associated with cholinergic loss.
Flexner
J B
JB
Department of Anatomy, School of Medicine, University of Pennsylvania, Philadelphia 19104.
Church
A C
AC
Flexner
L B
LB
D000109:Acetylcholine / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000502:physiology*; D051379:Mice; D011691:Puromycin / Q000494:pharmacology; D017447:Receptors, Dopamine D1 / Q000187:drug effects / Q000502:physiology; D017448:Receptors, Dopamine D2 / Q000187:drug effects / Q000502:physiology; D012601:Scopolamine / Q000494:pharmacology
D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D011691:Puromycin; D012601:Scopolamine; D006220:Haloperidol; D000109:Acetylcholine; D004298:Dopamine