[Effect of phytoecdysteroids and nerobol on parameters of carbohydrate and lipid metabolism and phospholipid spectrum of liver mitochondrial membrane in experimental diabetes mellitus of rats].
Phytoecdysteroids: ecdysterone and turkesterone, introduced orally to male rats with the body mass 180-120 g in a dose of 5 mg/l kg of mass and nerobol in a dose of 10 mg per 1 kg of the mass for 15 days against a background of the developed alloxan diabetes cause a considerable decrease in the content of free fatty acids of the blood serum, sharply increased after the subcutaneous injection of alloxan to the animals (150 mg per 1 kg of the mass). The content of glycogen, malonic dialdehyde, pyruvic acid and calcium transporting function of the liver mitochondria are also normalized. These changes are closely interrelated (and may be mutually conditioned) with the preparation-induced reduction of phospholipid spectrum of the liver mitochondrial membranes pathologically changed owing to insulin insufficiency. In this case phytoecdysteroids in the first turn normalize the fractions of phospholipids which play the structural role in the mitochondrial membranes, and nerobol normalizes the level of minor and monoacylic phospholipids.
Syrov
V N
VN
Tashmukhamedova
M A
MA
Khushbaktova
Z A
ZA
Mirtalipov
D T
DT
Mamatkhanov
A U
AU
D000818:Animals; D002118:Calcium / Q000378:metabolism; D050260:Carbohydrate Metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D004441:Ecdysterone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D007425:Intracellular Membranes / Q000187:drug effects / Q000378:metabolism; D050356:Lipid Metabolism; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008696:Methandrostenolone / Q000494:pharmacology*; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D051381:Rats
D005230:Fatty Acids, Nonesterified; D008112:Liver Glycogen; D010743:Phospholipids; D011773:Pyruvates; D008315:Malondialdehyde; D004441:Ecdysterone; C017787:turkesterone; D019289:Pyruvic Acid; D008696:Methandrostenolone; D002118:Calcium
Vliianie fitoékdisteroidov i nerobola na pokazateli uglevodnogo i lipidnogo obmenov i fosfolipidnyĭ spektr membran mitokhondriĭ pecheni krys pri éksperimental'nom sakharnom diabete.