Inhibitory effect of curcumin on fatty acid desaturation in Mortierella alpina 1S-4 and rat liver microsomes.
An extract of rhizomes of Curcuma longta L. (turmeric) inhibited the desaturation of dihomo-gamma-linolenic acid (DGLA) in the arachidonic acid (AA) producing fungus Mortierella alpina 1S-4. The factor responsible for this phenomenon was isolated and identified as curcumin (diferuloyl methane). Mycelial DGLA levels increased about two-fold (22.3 mg/g dry weight) with a concomitant decrease in AA levels when the fungus was cultivated with curcumin. The 50% inhibitory concentration against delta 5 desaturase was 27.2 microM. Curcumin also inhibited rat liver microsomal delta 5 and delta 6 desaturases.
Shimizu
S
S
Department of Agricultural Chemistry, Kyoto University, Japan.
Jareonkitmongkol
S
S
Kawashima
H
H
Akimoto
K
K
Yamada
H
H
D015126:8,11,14-Eicosatrienoic Acid / Q000378:metabolism; D000818:Animals; D016718:Arachidonic Acid / Q000096:biosynthesis; D003474:Curcumin / Q000302:isolation & purification / Q000494:pharmacology*; D044943:Fatty Acid Desaturases / Q000187:drug effects*; D005227:Fatty Acids / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects*; D009090:Mucorales / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017365:Spices
D005227:Fatty Acids; D010936:Plant Extracts; D016718:Arachidonic Acid; D044943:Fatty Acid Desaturases; D015126:8,11,14-Eicosatrienoic Acid; D003474:Curcumin