title: Application of Corynebacterium cutis lysate as an immune stimulant in cattle.
abstract: An ultrasonicated lysate of Corynebacterium cutis (Ultracorn, Virbac, France) was administered to 10-day-old calves, 5-month-old calves, and pregnant dams kept under Egyptian environmental conditions. Ninety-five calves and 50 dams were used in the study. All animals were treated with 2 ml/100 kg body weight of killed C cutis. Its effects on body weight gain and on calf mortality and morbidity were recorded. The results obtained showed that treated calves had greater weight gains, reduced susceptibility to common viral pathogens, and lower mortality. When given simultaneously with rinderpest vaccine, an immunopotentiating or adjuvant effect was seen. Thus, treated calves had higher neutralizing antibody titers to rinderpest as compared with untreated calves. When administered to pregnant cows in the last month of pregnancy, the offspring of these animals had higher birth weight, better weight gain, and reduced morbidity.
authors.affiliation: Department of Microbiology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
authors.forename: M A
authors.initials: MA
authors.lastname: Shalaby
authors.forename: S M
authors.initials: SM
authors.lastname: Saleh
authors.forename: S
authors.initials: S
authors.lastname: el-Atrash
authors.forename: A M
authors.initials: AM
authors.lastname: Sami
authors.forename: A A
authors.initials: AA
authors.lastname: el-Sanousi
authors.forename: M A
authors.initials: MA
authors.lastname: Saber
authors.forename: M I
authors.initials: MI
authors.lastname: Reda
mesh_terms: D000276:Adjuvants, Immunologic / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D003352:Corynebacterium / Q000737:chemistry*; D005260:Female; D008297:Male; D011247:Pregnancy; D012302:Rinderpest virus / Q000276:immunology; D014709:Vero Cells; D014765:Viral Vaccines / Q000008:administration & dosage
chemical_list: D000276:Adjuvants, Immunologic; D001500:BCG Vaccine; D014765:Viral Vaccines