title: Autosomal dominant polycystic kidney disease complicated by glomerulonephritis.
abstract: Two patients with autosomal dominant polycystic kidney disease (ADPKD) and concurrent glomerulonephritis are described. Both developed nephrotic-range proteinuria and one showed a concomitant acceleration in the rate of decline of renal function. Subsequent open renal biopsy revealed membrano-proliferative type-1 and mesangio-proliferative glomerulonephritis, respectively. Nephrotic-range proteinuria in the presence of ADPKD, with or without an accompanying decline in renal function, should prompt further investigation to exclude coexisting glomerular disease.
authors.affiliation: Department of Nephrology, Royal South Hants Hospital, Southampton, UK.
authors.forename: M T
authors.initials: MT
authors.lastname: Villar
authors.forename: P
authors.initials: P
authors.lastname: Bass
authors.forename: G
authors.initials: G
authors.lastname: Dewhurst
authors.forename: J M
authors.initials: JM
authors.lastname: Theaker
authors.forename: J R
authors.initials: JR
authors.lastname: Dathan
mesh_terms: D000328:Adult; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D009404:Nephrotic Syndrome / Q000150:complications; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications* / Q000473:pathology; D011507:Proteinuria / Q000150:complications