The relation of prothrombin times to coronary heart disease risk factors among men aged 31-45 years.
Although levels of coagulation factor VII and fibrinogen are predictive of cardiovascular disease, relatively little data describe hemostatic characteristics in healthy populations. The cross-sectional associations between the prothrombin time, a measure of the activity of the extrinsic and common pathways of coagulation, and traits associated with the risk of cardiovascular disease were therefore examined among 3,604 white and 514 black, male, US Army veterans aged 31-45 years. The prothrombin time measurements, performed in 1985 and 1986, were precise, with an intraclass correlation of 0.98 (202 pairs). Overall, the mean prothrombin time was 12.4 seconds (standard deviation, 0.4 seconds), and 11 percent of the men had a value of less than 12 seconds. Many of the observed associations with the prothrombin time paralleled those that have been reported with clotting factor VII and fibrinogen. The mean prothrombin time was 0.15 seconds shorter among whites than among blacks and was 0.2 seconds shorter among current cigarette smokers than among men who had never smoked. Inverse associations were also seen with relative weight and with levels of total cholesterol and triglycerides (r = -0.09 to -0.16). All associations were statistically significant at the 0.01 level, and the examined characteristics could jointly account for about 12 percent of the variability in prothrombin times. Additional data on characteristics related to coagulation may help elucidate the natural history of cardiovascular disease and aid in the design of clinical trials.
Freedman
D S
DS
Division of Nutrition, Centers for Disease Control, Atlanta, GA 30333.
Byers
T
T
Barboriak
J J
JJ
Flanders
W D
WD
Duncan
A
A
Yip
R
R
Meilahn
E N
EN
D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects / Q000453:epidemiology; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D006801:Humans; D008107:Liver Diseases / Q000150:complications / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D008889:Military Personnel; D011237:Predictive Value of Tests; D011517:Prothrombin Time; D044469:Racial Groups; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D014280:Triglycerides / Q000097:blood; D014481:United States / Q000453:epidemiology
D008076:Cholesterol, HDL; D014280:Triglycerides; D002784:Cholesterol