[Functional and diagnostic significance of A-, Bbeta 1-42 and Bbeta 15-42 peptide fragments of fibrin(ogen)].
A scheme of in vitro formation and hydrolysis of the fibrin clot is suggested. This scheme considers the data concerning a cofactor role of fibrin in activation of polymerization and fibrinolysis. Such parameters of a number of components as concentration of A-, B beta 1-42-and B beta 15-42 peptides and of other fragments of fibrinogen which allow characterizing a state of hyperfibrinolysis, hyperclotting or dynamic equilibrium of these systems are selected in the scheme.
Makogonenko
E M
EM
Lugovskoĭ
E V
EV
Kolesnik
L A
LA
Kudinov
S A
SA
D001777:Blood Coagulation / Q000502:physiology; D005337:Fibrin / Q000378:metabolism / Q000502:physiology*; D005338:Fibrin Fibrinogen Degradation Products; D005341:Fibrinolysin / Q000502:physiology; D005342:Fibrinolysis / Q000502:physiology; D005345:Fibrinopeptide B / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D006868:Hydrolysis; D010446:Peptide Fragments / Q000378:metabolism / Q000502:physiology*; D013917:Thrombin / Q000502:physiology; D013927:Thrombosis / Q000175:diagnosis / Q000378:metabolism*
D005338:Fibrin Fibrinogen Degradation Products; D010446:Peptide Fragments; C035285:fibrinogen Bbeta (1-42); C033786:fibrinogen Bbeta (15-42); D005345:Fibrinopeptide B; D005337:Fibrin; D013917:Thrombin; D005341:Fibrinolysin
O funktsional'nom i diagnosticheskom znechenii A-, Bbeta 1-42 i Bbeta 15-42 peptidnykh fragmentov fibrin(ogen)a.