title: New oral system for timing-release of drugs.
abstract: Polymeric barriers applied by compression have already been used to control drug release rate from matrix tablets. In this paper, polymeric barrier layers, used to prepare and develop a new device able to release the drug after a programmable period of time, are described. Some matrix core formulations, containing Trapidil or Sodium Diclofenac as a model drug, were dry-coated using either a swellable or an erodible shell. This coating prevents drug release from the core until the polymeric layer is not completely eroded or swollen. The time-lag can be modified by changing the barrier formulation and/or the coating thickness. Also drug release profiles (release rate and kinetics), can be widely modified changing the barrier layer characteristics.
authors.affiliation: Dipartimento di Chimica Farmaceutica, Università di Pavia, Italy.
authors.forename: U
authors.initials: U
authors.lastname: Conte
authors.forename: L
authors.initials: L
authors.lastname: Maggi
authors.forename: P
authors.initials: P
authors.lastname: Giunchedi
authors.forename: A
authors.initials: A
authors.lastname: La Manna
mesh_terms: D003692:Delayed-Action Preparations; D004008:Diclofenac / Q000008:administration & dosage / Q000493:pharmacokinetics; D005079:Excipients; D013607:Tablets; D014192:Trapidil / Q000008:administration & dosage / Q000493:pharmacokinetics
chemical_list: D003692:Delayed-Action Preparations; D005079:Excipients; D013607:Tablets; D004008:Diclofenac; D014192:Trapidil