title: [Determination of serum procollagen-III peptide in chronic liver diseases. Clinical usefulness].
abstract: Liver fibrosis determines the course and prognosis of chronic liver disease. Histological examination of liver biopsy is essential for diagnosing hepatic disease. Evaluation of serum concentration procollagen III peptides (sPIIIP) by radioimmunoassay (RIA) is a biochemical test useful for evaluating a fibrotic process. We have investigated 20 healthy subjects and 50 patients with chronic liver disease, histologically diagnosed by percutaneous liver biopsy: steatosis (8), fibrosteatosis (7), chronic persistent hepatitis (10), chronic active hepatitis (7), cirrhosis (18). SPIIIP levels were increased in patients with cirrhosis and chronic active hepatitis and in these groups of patients such levels were well correlated with histological activity of hepatic disease. Evaluation of serum concentration of PIIIP by RIA seems to be a useful test for evaluating a fibrotic process in chronic liver diseases evolving towards cirrhosis.
authors.affiliation: Divisione di Medicina Generale II, USSL n. 34, Regione Lombardia Presidi Ospedalieri di Chiari-Rovato, Brescia.
authors.forename: A
authors.initials: A
authors.lastname: Pagani
authors.forename: P
authors.initials: P
authors.lastname: Zigliani
authors.forename: A
authors.initials: A
authors.lastname: Pranzo
authors.forename: T
authors.initials: T
authors.lastname: Galante
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004796:Clinical Enzyme Tests; D003937:Diagnosis, Differential; D005234:Fatty Liver / Q000097:blood / Q000175:diagnosis; D005260:Female; D006505:Hepatitis / Q000097:blood / Q000175:diagnosis; D006521:Hepatitis, Chronic / Q000097:blood / Q000175:diagnosis; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis; D008107:Liver Diseases / Q000097:blood* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D011347:Procollagen / Q000097:blood*; D011379:Prognosis
chemical_list: D010446:Peptide Fragments; D011347:Procollagen; C041876:procollagen Type III-N-terminal peptide
vernacular_title: La determinazione sierica del peptide del procollagene-III nella epatopatia cronica. Utilità clinica.