title: Grade II and grade III hypothyroidism in rapid-cycling bipolar patients.
abstract: Thyroid function was evaluated in 10 rapid-cycling bipolar patients who had previously responded to lithium treatment. Five patients had grade II and 1 patient had grade III hypothyroidism as determined by thyrotropin-releasing hormone tests. Treatment with thyroxine in addition to lithium significantly decreased the intensity and frequency of rapid cycling episodes.
authors.affiliation: St Mary's Hospital, Montreal, Quebec, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Kusalic
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D008094:Lithium / Q000008:administration & dosage; D008297:Male; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine / Q000008:administration & dosage
chemical_list: D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D008094:Lithium; D013974:Thyroxine