[The effect of therapy with cytostatics and immunomodulators on mitotic pathology in Lewis tumor cells in mice].
The effect of cytostatics (methylnitrosourea and methotrexate), immunomodulators (thymalin and reaferon) and their combinations on the mitotic pathology of mice Lewis tumour cells was studied. It was revealed that chemotherapy with these agents changed the interrelation between mitotic phases and somewhat enhanced the incidence of pathologic mitoses mainly connected with the damage of mitotic apparatus. Immunomodulators differently affected the cytostatic activity of antitumour agents that may be associated with their mechanisms of action.
Potapov
Iu N
IuN
Krutova
T V
TV
Pashkova
V S
VS
Khaleev
D V
DV
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004354:Drug Screening Assays, Antitumor; D004359:Drug Therapy, Combination; D007370:Interferon Type I / Q000008:administration & dosage; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008770:Methylnitrosourea / Q000008:administration & dosage; D051379:Mice; D008810:Mice, Inbred C57BL; D008938:Mitosis / Q000187:drug effects*; D009368:Neoplasm Transplantation; D011994:Recombinant Proteins; D013951:Thymus Hormones / Q000008:administration & dosage
D000276:Adjuvants, Immunologic; D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D013951:Thymus Hormones; D008770:Methylnitrosourea; C032805:thymalin; D008727:Methotrexate
Vliianie terapii tsitostatikami i immunomoduliatorami na patologiiu mitoza v kletkakh opukholi L'iuis mysheĭ.