Inflammatory familial palmoplantar keratoderma: Greither's disease?
A case of a familial palmoplantar inflammatory keratoderma with autosomal dominant inheritance is reported. Associated clinical features included vasomotor troubles and hyperhidrosis consistent with a diagnosis of Greither's disease. Light microscopy was nonspecific. Electron microscopy showed aggregated tonofilaments around the nucleus, without true clumps. Desmosomes were numerous and cell-cell junctions showed an imbricated pattern, well demonstrated in the stratum corneum. The diagnosis of Greither's keratoderma is discussed.
Beylot-Barry
M
M
Service de Dermatologie, Hôpital des Enfants, Bordeaux, France.
Taïeb
A
A
Surlève-Bazeille
J E
JE
Maleville
J
J
D000328:Adult; D002675:Child, Preschool; D004487:Edema / Q000150:complications; D005260:Female; D006801:Humans; D007249:Inflammation; D007645:Keratoderma, Palmoplantar / Q000150:complications / Q000235:genetics* / Q000473:pathology*; D008297:Male; D012867:Skin / Q000473:pathology / Q000648:ultrastructure