Differentiation of a primitive neuroectodermal tumor into a benign ganglioglioma.
We describe a case of cerebellar neuroblastoma with histologic documentation of maturation into a ganglioglioma sixteen months later. Only chemotherapy was administered following the initial surgery and the child is well and disease-free three years following her final surgical procedure. The outcome of this patient supports previous hypotheses that the cerebellar neuroblastoma may be a less malignant tumor than its other primitive neuroectodermal posterior fossa counterparts. Furthermore, this case suggests a role for second-look surgery in the management of selected pediatric brain tumors.
Geyer
J R
JR
Children's Hospital & Medical Center, University of Washington, Seattle.
Schofield
D
D
Berger
M
M
Milstein
J
J
D002454:Cell Differentiation; D002528:Cerebellar Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007223:Infant; D009447:Neuroblastoma / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D012086:Reoperation