title: Enhanced chromosomal fragility in neuroblastoma: correlation with poor prognosis.
abstract: In a previous study we demonstrated spontaneous fragility and hypersensitivity to fragile site induction by aphidicolin in lymphocytes from some neuroblastoma patients and their parents. Here we report data based on a total of 40 patients and 37 families. Possible correlations between higher sensitivity to aphidicolin and a variety of personal and clinical characteristics were verified. Patients with a poor prognosis generally proved to be more susceptible to fragile site induction.
authors.affiliation: Department of Public Health and Cell Biology, 2nd University of Rome, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Vernole
authors.forename: B
authors.initials: B
authors.lastname: Tedeschi
authors.forename: G
authors.initials: G
authors.lastname: Melino
authors.forename: C
authors.initials: C
authors.lastname: Pianca
authors.forename: B
authors.initials: B
authors.lastname: Nicoletti
mesh_terms: D000328:Adult; D000367:Age Factors; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology*; D011379:Prognosis; D012016:Reference Values