title: Neuropsychological function and REM sleep in schizophrenic patients.
abstract: To test the hypothesis that rapid eye movement (REM) sleep in schizophrenic patients is associated with cognitive function, we studied 18 schizophrenic inpatients by means of electroencephalograms taken during sleep in their own hospital beds after a minimum 2-wk medication withdrawal period. Patients underwent neuropsychological tests to measure memory function and other aspects of cognitive performance. REM sleep measures demonstrated positive and negative correlations with cognition and memory measures, depending on when REM occurred after sleep onset. Minutes of REM sleep and REM density in the first period correlated negatively with performance, while REM minutes occurring after the first REM period correlated positively with neuropsychological performance. Further work should test whether phasic REM sleep regulation at the beginning of the night plays a compensatory role for neuropsychological dysfunction in schizophrenics.
authors.affiliation: University of Michigan, Department of Psychiatry, Ann Arbor 48109.
authors.forename: S F
authors.initials: SF
authors.lastname: Taylor
authors.forename: R S
authors.initials: RS
authors.lastname: Goldman
authors.forename: R
authors.initials: R
authors.lastname: Tandon
authors.forename: J E
authors.initials: JE
authors.lastname: Shipley
mesh_terms: D000328:Adult; D003072:Cognition Disorders; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis* / Q000503:physiopathology; D012565:Schizophrenic Psychology; D012895:Sleep, REM; D014888:Wechsler Scales