title: Lung injury by amiodarone, an antiarrhythmic drug, in male rats.
abstract: Administration of single dose (175 mg/kg body wt) of amiodarone dissolved in water through gavage for 3 weeks damaged the lung and changed the content of lung lavage. Activities of bronchoalveolar lavage (BAL) angiotensin converting enzyme (ACE) and lactate dehydrogenase (LDH) increased significantly. Also, the protein and lactate content of the lavage fluid increased significantly over the control. The drug also produced marked changes in morphology of the lung of experimental animals.
authors.affiliation: Department of Biochemistry, University of Madras, India.
authors.forename: B
authors.initials: B
authors.lastname: Padmavathy
authors.forename: S
authors.initials: S
authors.lastname: Niranjali
authors.forename: H
authors.initials: H
authors.lastname: Devaraj
mesh_terms: D000638:Amiodarone / Q000633:toxicity*; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D007770:L-Lactate Dehydrogenase / Q000096:biosynthesis; D007773:Lactates / Q000096:biosynthesis; D019344:Lactic Acid; D008168:Lung / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D007773:Lactates; D019344:Lactic Acid; D007770:L-Lactate Dehydrogenase; D000638:Amiodarone