Hilar and mediastinal lymphadenopathy with hypersensitivity pneumonitis induced by penicillin.
A 54-year-old Japanese man demonstrated a sultamicillin-induced hilar and mediastinal lymphadenopathy with hypersensitivity pneumonitis. A positive lymphocyte stimulation test for sultamicillin and a decreased CD4/CD8 ratio of lymphocytes in BAL fluid suggested that an alteration in cell-mediated mechanisms was responsible for the patient's symptoms.
Yonemaru
M
M
First Department of Medicine, Tokyo Medical College, Japan.
Mizuguchi
Y
Y
Kasuga
I
I
Utsumi
K
K
Ichinose
Y
Y
Toyama
K
K
D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced*; D000667:Ampicillin / Q000009:adverse effects*; D001365:Axilla; D002968:Clavicle; D003875:Drug Eruptions / Q000209:etiology; D004359:Drug Therapy, Combination / Q000009:adverse effects; D006119:Groin; D006801:Humans; D008168:Lung; D008206:Lymphatic Diseases / Q000139:chemically induced*; D008297:Male; D008482:Mediastinum; D008875:Middle Aged; D013407:Sulbactam / Q000009:adverse effects*
C035444:sultamicillin; D000667:Ampicillin; D013407:Sulbactam