The effect of chloral hydrate and its metabolites, trichloroethanol and trichloroacetic acid, on bilirubin-albumin binding.
Chloral hydrate is used as a sedative in infants requiring ventilatory support. The metabolites, trichloroethanol and trichloroacetic acid, accumulate in the serum and are protein bound. The possibility that these chemicals might compete with bilirubin for albumin binding was tested using the peroxidase method and a dialysis rate method. Chloral hydrate and trichloroethanol had no effect on bilirubin-albumin binding. Trichloroacetic acid affects bilirubin-albumin binding but to a degree that would be dangerous only in infants with an unusual accumulation of this metabolite.
Onks
D L
DL
Department of Paediatrics, East Carolina University School of Medicine, Greenville, North Carolina 27858.
Robertson
A F
AF
Brodersen
R
R
D001663:Bilirubin / Q000378:metabolism*; D002697:Chloral Hydrate / Q000378:metabolism / Q000633:toxicity*; D005023:Ethylene Chlorohydrin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000633:toxicity; D006801:Humans; D010084:Oxidation-Reduction; D011485:Protein Binding; D012044:Regression Analysis; D012709:Serum Albumin / Q000378:metabolism*; D013056:Spectrophotometry, Ultraviolet; D014238:Trichloroacetic Acid / Q000633:toxicity*
D012709:Serum Albumin; D002697:Chloral Hydrate; D014238:Trichloroacetic Acid; D005023:Ethylene Chlorohydrin; C005849:2,2,2-trichloroethanol; D001663:Bilirubin