title: Metabolism of the malignant cell, the role of bacterial spores, and a pictorial presentation to substantiate the latter's presence as an etiological factor in carcinogenesis.
abstract: The respiration and metabolism of the malignant cell, while in vivo, is anaerobic. This is contrary to a normal animal (human) cell, whose respiration and metabolism is aerobic. There is a factor within the malignant cell which produces a reducing or 'deoxygenating' phenomenon, creating the metabolic anaerobiosis. An animal cell cannot survive without the ultimate oxygen molecule. Yet the malignant cell continues to grow and enlarge despite this oxygen absence. Even more surprising is the fact that the malignant cell requires the circulating flow of blood, otherwise that deficient site or area will ulcerate, slough, or necrotize. Investigative studies clearly indicate that there are present 'spores' of a specific group type of plant micro-organism within the malignant cell, and in the immediate and circumferential area to account for this abnormal physiology. In summarizing all the experimentally uncovered facts, it becomes apparent that the malignant cell, while in vivo, is the consequence of 3 factors of productivity. For the first factor there is the requirement of a tissue site whereby there is an accumulate number of the chronic defense cells as the reticuloendothelial group, squamous, and/or epithelial cells. The second factor requires the presence and phagocytosis of these specific plant bacterial spores that can survive genetically within a sac or cell, and third, for the adequate circulating flow of blood by the host. Because of this, 3 factor product activity, Koch's postulate cannot be fulfilled as a criterion for the etiology of the cancer cell. We have, however, a pictorial summary of the pertinent uncovered facts that, when added together, presents a credible, logical, and valid conclusion to support the concept that these specific bacterial spores contribute to the pathway of activity to associate them as the malefactor in carcinogenesis.
authors.affiliation: North Detroit General Hospital, MI 48212.
authors.forename: M W
authors.initials: MW
authors.lastname: White
mesh_terms: D000693:Anaerobiosis; D000818:Animals; D003043:Cocarcinogenesis; D006801:Humans; D051379:Mice; D008811:Mice, Inbred DBA; D009369:Neoplasms / Q000378:metabolism* / Q000382:microbiology* / Q000648:ultrastructure; D010100:Oxygen / Q000378:metabolism; D013171:Spores, Bacterial / Q000378:metabolism; D013211:Staphylococcus aureus / Q000302:isolation & purification
chemical_list: D010100:Oxygen