title: A primary cutaneous multi-lobed B-cell lymphoma.
abstract: Multi-lobed non-Hodgkin's lymphoma (NHL) has recently been recognized as a NHL variant. A patient presented with a scalp nodule which, upon skull X-Ray, was seen to be associated with a bone defect. Immunophenotyping clearly demonstrated that this was a B-cell proliferation. Histologically the B-lymphocytes were closely related to centroblasts. There were no other extra cutaneous localizations. The present report emphasizes the importance of this clinico anatomical entity which shows prominent extra-nodal involvement, large lymphoid cells with multi-lobed nuclei and a good response to chemotherapy. Multi-lobed NHL may be a T-cell lymphoma, or a B-cell lymphoma closely related to centroblastic NHL. Although multi-lobed lymphomas have a predilection for cutaneous localizations, our case is the first primary cutaneous multi-lobed B-NHL, proven by immunophenotyping.
authors.affiliation: Department of Dermatology, C.H.U. Trousseau, Tours, France.
authors.forename: L
authors.initials: L
authors.lastname: Vaillant
authors.forename: A
authors.initials: A
authors.lastname: De Muret
authors.forename: C
authors.initials: C
authors.lastname: Monegier Du Sorbier
authors.forename: C
authors.initials: C
authors.lastname: Muller
authors.forename: G
authors.initials: G
authors.lastname: Lorette
mesh_terms: D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000473:pathology*; D008875:Middle Aged; D012535:Scalp; D012878:Skin Neoplasms / Q000473:pathology*