Vitamin B12 improves cognitive disturbance in rodents fed a choline-deficient diet.
The effect of vitamin B12 on learning disturbance was tested in rats. Rats were fed a choline-enriched, choline-deficient, and choline-deficient diet with vitamin B12. Concentrations of acetylcholine in the brain were significantly lower in rats fed a choline-deficient diet than rats fed a choline-enriched diet. Passive avoidance learning shows that rats on a choline-deficient diet showed significantly impaired learning compared to rats on a choline-enriched diet. However, there was no significant difference of acetylcholine in the brain or in the passive avoidance learning between rats fed a choline-enriched and a choline-deficient with vitamin B12 diet. We, therefore, suggest that vitamin B12 potentiates learning in an acetylcholine-deprived brain.
Sasaki
H
H
Department of Geriatric Medicine, Tohoku University School of Medicine, Sendai, Japan.
Matsuzaki
Y
Y
Meguro
K
K
Ikarashi
Y
Y
Maruyama
Y
Y
Yamaguchi
S
S
Sekizawa
K
K
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D002794:Choline / Q000378:metabolism; D002796:Choline Deficiency / Q000523:psychology*; D003071:Cognition / Q000187:drug effects*; D004032:Diet; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D014805:Vitamin B 12 / Q000494:pharmacology*
D002794:Choline; D000109:Acetylcholine; D014805:Vitamin B 12