title: [A case of hyperalphalipoproteinemia with complete deficiency of cholesteryl ester transfer activity].
abstract: A 68-year-old male patient with benign hypertension shows high levels of high density lipoprotein cholesterol (HDL-C) of 171 mg/dl. The serum total cholesterol was 240 mg/dl. An abnormal slow alpha band and polydisperse low density lipoprotein (LDL) bands were detected by agarose gel and polyacrylamide gel electrophoresis. The slow alpha band was considered as an apo E-rich HDL. A peak of large HDL particle and a peak of abnormal high-molecular-LDL particle were observed in the patient's serum by gel permeation high performance liquid chromatography. Cholesteryl ester transfer activity (CETA) of the patient's serum was completely deficient (0.0%/10 microliters/18 hr). From these results, it is strongly suggested that patient's hyper-HDL-cholesterolemia caused by a complete deficiency of CETA.
authors.affiliation: Clinical Laboratories, Asahikawa Medical College Hospital.
authors.forename: Y
authors.initials: Y
authors.lastname: Umemori
authors.forename: T
authors.initials: T
authors.lastname: Moriyama
authors.forename: S
authors.initials: S
authors.lastname: Takeda
authors.forename: H
authors.initials: H
authors.lastname: Hosokawa
authors.forename: M
authors.initials: M
authors.lastname: Nobuoka
authors.forename: M
authors.initials: M
authors.lastname: Makino
authors.forename: H
authors.initials: H
authors.lastname: Matuhashi
authors.forename: M
authors.initials: M
authors.lastname: Eto
authors.forename: N
authors.initials: N
authors.lastname: Sakai
authors.forename: H
authors.initials: H
authors.lastname: Chiba
mesh_terms: D000368:Aged; D002352:Carrier Proteins / Q000032:analysis*; D053480:Cholesterol Ester Transfer Proteins; D002851:Chromatography, High Pressure Liquid; D004586:Electrophoresis; D006023:Glycoproteins; D006801:Humans; D006951:Hyperlipoproteinemias / Q000209:etiology*; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male
chemical_list: C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D006023:Glycoproteins; D008075:Lipoproteins, HDL