Is liver to lung shunting in colorectal liver metastasis the cause of toxicity following treatment with cytotoxic microsphere aggregates?
Incorporation of cytotoxic drugs into microspheres reduces but does not eliminate systemic toxicity. The extent of liver to lung shunt was measured in 26 patients with colorectal liver metastasis. Liver to lung shunting correlated with proportion of liver replacement but did not exceed 4.4% and therefore is unlikely to cause systemic toxicity.
Hennigan
T W
TW
Department of Surgery, Charing Cross and Westminster Medical School, London, UK.
Earlam
S
S
Allen-Mersh
T G
TG
D015179:Colorectal Neoplasms; D004621:Embolization, Therapeutic; D006801:Humans; D015918:Infusion Pumps, Implantable; D008099:Liver / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000473:pathology; D008113:Liver Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary*; D008168:Lung / Q000098:blood supply*; D008863:Microspheres; D010316:Particle Size; D011877:Radionuclide Imaging