[Therapy of stomach ulcer--a comparison between the low dosage antacid hydrotalcite and ranitidine--results of a randomized multicenter double-blind study. Talcivent Study Group].
In a 8 week double-blind randomized multicenter trial in 159 patients with benign gastric ulcer the efficacy of hydrotalcite vs. ranitidine in expediting ulcer healing and in achieving pain relief was determined. 79 patients received hydrotalcite 1000 mg q.i.d. as tablets equalling a total neutralizing capacity of 111.2 mval and 80 patients received ranitidine (300 mg at night). Endoscopically controlled healing rates after 4 weeks of therapy amounted to 41.8% with hydrotalcite and 53.8% with ranitidine. After 8 weeks both regimen showed significant equivalent healing rates (hydrotalcite: 81.0%, ranitidine: 78.8%, p < 0.003). Ulcer pain decreased parallel in both groups. By the end of therapy 92.4% of the patients treated with hydrotalcite and 86.3% of those receiving ranitidine were free of pain. Incidence of helicobacter pylori in antral mucosal biopsies was not influenced by both treatments. We conclude that an 8-week treatment with low dose hydrotalcite therapy is as effective as ranitidine in healing benign gastric ulcers and achieving pain relief.
Holtermüller
K H
KH
I. Medizinische Klinik St. Markus-Krankenhaus, Frankfurt a.M., Bundesrepublik Deutschland.
Liszkay
M
M
Bernard
I
I
Haase
W
W
D000328:Adult; D000368:Aged; D000536:Aluminum Hydroxide / Q000008:administration & dosage*; D000863:Antacids / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy; D016480:Helicobacter pylori; D006801:Humans; D008276:Magnesium Hydroxide / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D011899:Ranitidine / Q000008:administration & dosage*; D013276:Stomach Ulcer / Q000188:drug therapy*
D000863:Antacids; C010467:hydrotalcite; D000536:Aluminum Hydroxide; D011899:Ranitidine; D008276:Magnesium Hydroxide
Therapie des Ulcus ventriculi--Ein Vergleich zwischen dem niedrig dosierten Antazidum Hydrotalcit und Ranitidin--Ergebnisse einer randomisierten multizentrischen Doppelblindstudie. Talcivent Studiengruppe.