title: Cochlear and neural dysfunction in acoustic neuroma: can they be separately revealed by auditory brain-stem wave V latency?
abstract: Cochlear and retrocochlear lesions may be differentiated by a diagnostic index (D5), which is derived from the patient's auditory brain-stem wave V latency and pure-tone hearing threshold at 2 to 4 kHz. The D5 values obtained from 49 cases of acoustic neuroma (AN) have been shown to share some properties with D5 values of patients with cochlear hearing loss (280 cases), indicating a lesser prolongation of wave V latency in cases with pronounced hearing loss. Assuming this finding is indicative of some degree of cochlear impairment concomitant to the neural dysfunction, AN data were corrected in an attempt to remove the effects of cochlear impairment. The resulting D5 values could reflect the delay in wave V solely due to the neural dysfunction. A significant relationship between these D5 values and tumour size seems to support this hypothesis.
authors.affiliation: Audiology Service of ENT Clinic, University of Ferrara, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Prosser
authors.forename: E
authors.initials: E
authors.lastname: Arslan
authors.forename: M
authors.initials: M
authors.lastname: Turrini
authors.forename: M
authors.initials: M
authors.lastname: Rosignoli
mesh_terms: D000328:Adult; D000368:Aged; D001775:Blood Circulation; D003051:Cochlea / Q000503:physiopathology; D015834:Cochlear Diseases / Q000175:diagnosis / Q000503:physiopathology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005260:Female; D006309:Hearing / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D009464:Neuroma, Acoustic / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D000159:Vestibulocochlear Nerve / Q000503:physiopathology