[The pharmacological correction of recurrent immediate-type allergic reactions].
The effect of drugs on the early and late phases of repeated allergic reactions (RAR) was studied in experiments on rabbits. The action of the drugs was estimated by the number of challenge doses of antigen, endured by survived and dead rabbits, percentage of the animals' death, and by the place of each group on the lethality scale. Diphenhydramine, ouabain and their combinations, silver nitrate (20 mg/kg) and DOCA enhanced whereas histamine, unithiol, cholesterol, and silver nitrate (20 and 0.2 mg/kg) decreased allergization in the period of RAR. The characteristic features of the action of the drugs on RAR were revealed and compared to the first allergic reaction. Qualitative and quantitative differences were shown in the action of different drug doses and combinations on RAR. The authors provide evidence for the possibility of treating allergic diseases by drug administration in a quiet period.
Chetverikov
G N
GN
Dianova
R G
RG
Smirnova
V V
VV
Tabakova
T D
TD
Demidova
M A
MA
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D006969:Hypersensitivity, Immediate / Q000188:drug therapy* / Q000401:mortality; D007114:Immunization; D011817:Rabbits; D012008:Recurrence; D013997:Time Factors
Farmakologicheskaia korrektsiia povtornykh allergicheskikh reaktsiĭ nemedlennogo tipa.