title: Scedosporium inflatum osteomyelitis in a dog.
abstract: Scedosporium inflatum Malloch et Salkin was found to cause osteomyelitis in a 6-year-old spayed female beagle. The previously healthy dog suddenly developed right-forelimb lameness. Bony changes consisting of proliferation with some lysis were noted on radiographic examinations. Microscopic observations of stained sections of tissue obtained by biopsy of the distal humerus revealed the presence of septate branching hyphae. Cultures inoculated with tissue from a later biopsy yielded a mold subsequently identified as S. inflatum. Tissue sections stained with specific Scedosporium fluorescent-antibody conjugate were positive, further substantiating the diagnosis. Although the dog was treated with oral itraconazole, no improvement in the animal's condition was noted, and it was euthanized. Autopsy revealed dissemination of the etiologic agent to the lungs.
authors.affiliation: Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201-0509.
authors.forename: I F
authors.initials: IF
authors.lastname: Salkin
authors.forename: C R
authors.initials: CR
authors.lastname: Cooper
authors.forename: J W
authors.initials: JW
authors.lastname: Bartges
authors.forename: M E
authors.initials: ME
authors.lastname: Kemna
authors.forename: M G
authors.initials: MG
authors.lastname: Rinaldi
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000175:diagnosis / Q000209:etiology* / Q000382:microbiology; D004285:Dogs; D005260:Female; D003904:Mitosporic Fungi / Q000302:isolation & purification / Q000648:ultrastructure; D009181:Mycoses / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D010019:Osteomyelitis / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*