[The role of humoral factors in the pathogenesis of the postoperative syndrome].
Blood plasma levels of "pain substances" (serotonin, histamine, prostaglandin F2 alpha, adrenaline /A/) and neuropeptides (beta-endorphin, somatostatin) have been evaluated in 39 patients during the early postoperative period after lung and mediastinum surgery. The studies have shown that the content of these biologically active substances increases considerably. Following stellate ganglion blockade A concentration decreased significantly, the uptake of narcotic analgesics used for postoperative analgesia reduced 1.7-fold, however the levels of "pain substances" and neuropeptides remained unchanged. It is believed that postoperative pain syndrome develops due to the elevation of the levels of the substances under study. Stellate ganglion blockade produces only sympatholytic effect, which shows the necessity of the elaboration of drug therapeutic techniques blocking "pain" receptors and using "pain substance" antagonists.
Gimmel'farb
G N
GN
Popova
I Iu
IIu
Iunusova
S B
SB
D000293:Adolescent; D000328:Adult; D001340:Autonomic Nerve Block; D015237:Dinoprost / Q000097:blood*; D004837:Epinephrine / Q000097:blood*; D005260:Female; D006632:Histamine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009479:Neuropeptides / Q000097:blood*; D010149:Postoperative Pain / Q000097:blood* / Q000517:prevention & control; D012701:Serotonin / Q000097:blood*; D013233:Stellate Ganglion
D009479:Neuropeptides; D012701:Serotonin; D006632:Histamine; D015237:Dinoprost; D004837:Epinephrine
Rol' nekotorykh gumoral'nykh faktorov v patogeneze posleoperatsionnogo bolevogo sindroma.