Lack of pharmacokinetic interactions between moxonidine and digoxin.
The potential for pharmacokinetic interactions between moxonidine and digoxin at steady-state was investigated in 15 healthy male volunteers. Multiple oral doses of 0.2mg moxonidine twice daily and 0.2mg digoxin once daily were administered alone and in combination in a randomised 3-period crossover design. The drugs were administered for at least 5 days. The results indicate that neither moxonidine nor digoxin influences the pharmacokinetics of the other drug under steady-state conditions.
Pabst
G
G
L.A.B. GmbH & Co., Neu-Ulm, Germany.
Weimann
H J
HJ
Weber
W
W
D000284:Administration, Oral; D000328:Adult; D000959:Antihypertensive Agents / Q000493:pharmacokinetics*; D004077:Digoxin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D004334:Drug Administration Schedule; D004347:Drug Interactions; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D008297:Male; D008875:Middle Aged
D000959:Antihypertensive Agents; D007093:Imidazoles; D004077:Digoxin; C043482:moxonidine