Effects of clonazepam on paired-pulse and frequency potentiation of evoked potentials in rats.
Three different monosynaptic evoked potentials (thalamocortical, interhemispheric, i.e. transcallosal, and entorhino-dentate) were used to study the paired-pulse and frequency potentiation in adult rats. A marked potentiation was seen in both neocortical responses under control conditions (up to 200%), whereas potentiation in the dentate gyrus was only moderate. Clonazepam (0.1 and/or 1 mg/kg, i.p.) antagonized the potentiation of the thalamocortical responses only, the frequency potentiation was suppressed in a dose-dependent manner, and the paired-pulse potentiation was significantly attenuated only by the higher dose of clonazepam. The potentiation of the cortical interhemispheric as well as of the entorhino-dentate evoked potentials was not changed by either dose of clonazepam. The present results do not form the hypothesis of frequency potentiation as a mechanism of epileptogenesis.
Kubová
H
H
Institute of Physiology, Czechoslovak Academy of Sciences, Prague.
Mares
P
P
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D002540:Cerebral Cortex / Q000502:physiology; D002998:Clonazepam / Q000494:pharmacology*; D003337:Corpus Callosum / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004567:Electrodes, Implanted; D005071:Evoked Potentials / Q000187:drug effects; D006624:Hippocampus / Q000502:physiology; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013788:Thalamus / Q000502:physiology
D000927:Anticonvulsants; D002998:Clonazepam