title: [Histologic reactions of the bone-implant zone and cortical bone area after long-term hip replacement].
abstract: 29 femora with cemented hip endoprostheses and 17 age related controls were analyzed regarding different histological criteria. All specimens were processed to undecalcified ultra thin grindings and in addition a few to surface stained block-grindings. The reactions at the bone implant interface in cases without loosening of the implant are: accumulation of macrophages and multinucleated giant cells, fibrous tissue membranes with a mean thickness of 103 microns and mineralization defects near the cement. The mean rate of direct bone/bone-cement contact is 2.7% of the whole cement surface. The phenomenons at the interface were explained as being the result of micromovement and resulting from wear and tear. The cortical bone demonstrates a remarkable loss of bone (up to 60% after 12 years) following an increase of osteoclastic resorption with no change of osteoblast activity. The localization of the bone loss indicates a relation to the new load situation after implantation.
authors.affiliation: Abteilung Osteopathologie, Universität Hamburg.
authors.forename: M
authors.initials: M
authors.lastname: Hahn
authors.forename: M
authors.initials: M
authors.lastname: Vogel
authors.forename: C
authors.initials: C
authors.lastname: Schultz
authors.forename: M
authors.initials: M
authors.lastname: Niecke
authors.forename: G
authors.initials: G
authors.lastname: Delling
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001843:Bone Cements; D001862:Bone Resorption / Q000473:pathology; D005260:Female; D005269:Femur / Q000473:pathology*; D005549:Foreign-Body Reaction / Q000473:pathology*; D015743:Giant Cells, Foreign-Body / Q000473:pathology; D006622:Hip Prosthesis; D006801:Humans; D008264:Macrophages / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000473:pathology*; D011475:Prosthesis Failure
chemical_list: D001843:Bone Cements
vernacular_title: Histologische Reaktionen an der Knochen-Implantat-Grenze und der Corticalis nach mehrjährigem Hüftgelenkersatz.