Feasibility of 19F imaging of perfluorochemical emulsions to measure myocardial vascular volume.
19F magnetic resonance images were obtained of the ventricular walls of isolated rabbit hearts perfused with a perfluorochemical (PFC) emulsion. Since the PFC is known to stay within the vascular space in normal myocardial tissue, the 19F signal should reflect myocardial vascular volume. 19F MRI of PFC emulsions represents a new investigational tool for the study of coronary vascular volume.
Judd
R M
RM
Department of Biomedical Engineering, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205.
Rottman
G A
GA
Forder
J R
JR
Yin
F C
FC
Blackband
S J
SJ
D000818:Animals; D001802:Blood Substitutes; D003326:Coronary Circulation / Q000502:physiology; D003331:Coronary Vessels / Q000033:anatomy & histology*; D005466:Fluorocarbons; D006321:Heart / Q000033:anatomy & histology*; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption / Q000502:physiology; D011817:Rabbits
D001802:Blood Substitutes; D005466:Fluorocarbons; C008807:perfluorotributylamine