Hemoglobin C--G-Georgia double heterozygosity: a case report.
A 12-month-old black female with an unremarkable past medical history was admitted to the hospital with respiratory distress and fever without identified sepsis. Despite mechanical ventilation, the patient died as a result of respiratory insufficiency secondary to severe necrotizing bronchitis and bronchiolitis with pneumonia. Electrophoretic and biochemical analyses of the patient's hemoglobin showed the patient to be a double heterozygote for hemoglobin C (a beta chain variant) and hemoglobin G-Georgia (an alpha chain variant). This is the first report of this combination of hemoglobin variants.
Reynolds
S
S
Department of Pathology/Laboratory Medicine, Medical University of South Carolina, Charleston 29425.
Miller
C
C
King
R
R
Lazarchick
J
J
D004586:Electrophoresis; D005260:Female; D006444:Hemoglobin C / Q000235:genetics*; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D007223:Infant
D006455:Hemoglobins, Abnormal; D006444:Hemoglobin C; C048521:hemoglobin G Georgia