title: Influence of thyroid status regulation and Synovex-S implants on growth performance and tissue gain in beef steers.
abstract: The separate and combined effects of Synovex-S (SYN) ear implants and thyroxine (T4)-5'-monodeiodinase inhibition (Trial 1) and T3 injection to create a mild elevation in circulating T3 concentrations (Trial 2) on BW gain and composition of gain were studied. Trial 1 used 24, 285-kg Angus steers in two experimental phases. Low-level feeding of propylthiouracil (PTU, 1.5 mg/kg BW daily) was used to achieve inhibition of T4-5'-monodeiodinase activity (TMA). Twelve steers received neither treatment (control) and 12 received SYN+PTU (hypothesized to maximize weight gain) from 0 to 56 d (phase 1) in a single factor treatment comparison. Subsequently, PTU was fed to six control steers and not fed to six of the original SYN+PTU steers from 56 to 175 d (phase 2) in a 2 x 2 arrangement of treatments. Trial 2 used 24, 302-kg Angus-Hereford steers. Treatments were without or with SYN and without or with sc injections of T3 in polyethylene glycol (2 micrograms/kg BW every 48 hr) in a 2 x 2 factorial arrangement of treatments. In both trials, all steers were individually fed a diet of a corn-based concentrate and silage mixture at an equal metabolizable energy intakes per unit of metabolic body weight (.25 Mcal/kg BW.75). Measurements of daily dry matter intakes, weekly BW, 28-d estimates of empty body components (measured by urea dilution), final TMA (trial 1) and plasma thyroid hormone concentrations were obtained. In both trials, SYN increased BW gain and protein accretion.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: U.S. Department of Agriculture, Beltsville, MD 20705.
authors.forename: T S
authors.initials: TS
authors.lastname: Rumsey
authors.forename: T H
authors.initials: TH
authors.lastname: Elsasser
authors.forename: S A
authors.initials: SA
authors.lastname: Norton
authors.forename: A S
authors.initials: AS
authors.lastname: Kozak
authors.forename: S
authors.initials: S
authors.lastname: Kahl
mesh_terms: D000818:Animals; D001823:Body Composition / Q000187:drug effects*; D002417:Cattle / Q000254:growth & development*; D004338:Drug Combinations; D004343:Drug Implants; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D011374:Progesterone / Q000494:pharmacology*; D011441:Propylthiouracil / Q000494:pharmacology; D013961:Thyroid Gland / Q000187:drug effects / Q000502:physiology*; D014284:Triiodothyronine / Q000494:pharmacology; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D004338:Drug Combinations; D004343:Drug Implants; D014284:Triiodothyronine; D011374:Progesterone; D004958:Estradiol; D011441:Propylthiouracil; C025370:estradiol benzoate, progesterone drug combination