title: Empty sella developing during thyroxine therapy in a patient with primary hypothyroidism and hyperprolactinaemia.
abstract: A 35 year old woman presented with severe primary hypothyroidism and galactorrhea. A very high prolactin level was also detected and computerized tomography scan of the sellar region demonstrated an enlarged pituitary gland associated with contrast enhancement. Replacement therapy with thyroxine corrected both biochemical and clinical abnormalities but empty sella developed during this therapy. It is concluded that empty sella may be related to thyroxine-induced shrinkage of lactotroph and/or thyrotroph cell hyperplasia.
authors.affiliation: Department of Internal Medicine, Ericyes University Medical School, Kayseri, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Kelestimur
authors.forename: A
authors.initials: A
authors.lastname: Selçuklu
authors.forename: N
authors.initials: N
authors.lastname: Ozcan
mesh_terms: D000328:Adult; D004652:Empty Sella Syndrome / Q000000981:diagnostic imaging / Q000209:etiology*; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000150:complications*; D007037:Hypothyroidism / Q000150:complications*; D010902:Pituitary Gland / Q000000981:diagnostic imaging; D013974:Thyroxine / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed
chemical_list: D013974:Thyroxine