title: Plasma and extracellular volume in calves: comparison between isotopic and 'cold' techniques.
abstract: While isotopic techniques have largely superseded traditional markers for the determination of the volume of fluid compartments in vivo, they are not always convenient, especially with diarrhoeic animals. A direct comparison was therefore made in week-old calves between Evans blue and radio-iodinated serum albumin as measures of plasma volume and thiocyanate or 24sodium as measures of extracellular fluid space. The correlation coefficients were excellent (1.00, 0.96; P < 0.001) and the calves had plasma and extracellular fluid volumes of 72 +/- 2 and 438 +/- 2 ml kg-1, respectively. The latter value is, though high, typical of young animals and comparable with other data in calves.
authors.affiliation: Department of Large Animal Medicine and Surgery, Royal Veterinary College, Hatfield, Hertfordshire.
authors.forename: A J
authors.initials: AJ
authors.lastname: Wagstaff
authors.forename: I
authors.initials: I
authors.lastname: Maclean
authors.forename: A R
authors.initials: AR
authors.lastname: Michell
authors.forename: P H
authors.initials: PH
authors.lastname: Holmes
mesh_terms: D000818:Animals; D001811:Blood Volume Determination / Q000379:methods / Q000662:veterinary*; D002417:Cattle / Q000502:physiology*; D005070:Evans Blue; D005110:Extracellular Space; D010953:Plasma Volume; D012711:Serum Albumin, Radio-Iodinated; D012979:Sodium Radioisotopes; D013861:Thiocyanates
chemical_list: D012711:Serum Albumin, Radio-Iodinated; D012979:Sodium Radioisotopes; D013861:Thiocyanates; D005070:Evans Blue; C024553:sodium thiocyanate