Utilization of determining lipid-bound sialic acid for the diagnosis and further prognosis of cancer.
In three types of tumors, rectal carcinoma, large intestine carcinoma and bronchogenic carcinoma, the level of lipid-bound sialic acid (LSA) was determined in blood serum before and after surgical operation. In all the cases, there was a significant increase of LSA content in comparison with healthy controls. Considerable increase in LSA values was observed in patients in relapse after surgical intervention. In contrast to this, in patients with regression the LSA levels were lower as compared with LSA levels prior to the surgical intervention. We believe that the method of determining LSA level could be used not only for the diagnosis of cancer, but also for the prognosis.
Polívková
J
J
Institute of Biophysics, 1st Faculty of Medicine, Charles University, Prague, Czechoslovakia.
Vosmiková
K
K
Horák
L
L
D002283:Carcinoma, Bronchogenic / Q000097:blood / Q000175:diagnosis; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000097:blood / Q000175:diagnosis; D008055:Lipids / Q000097:blood*; D008175:Lung Neoplasms / Q000097:blood / Q000175:diagnosis; D008297:Male; D019158:N-Acetylneuraminic Acid; D009369:Neoplasms / Q000097:blood / Q000175:diagnosis*; D011379:Prognosis; D012004:Rectal Neoplasms / Q000097:blood / Q000175:diagnosis; D012794:Sialic Acids / Q000097:blood*
D008055:Lipids; D012794:Sialic Acids; D019158:N-Acetylneuraminic Acid