Normal plasminogen activator inhibitor levels at long-term follow-up after jejuno-ileal bypass surgery in morbidly obese individuals.
Forty-five patients who had been subjected to jejuno-ileal bypass (JIB) surgery for morbid obesity and 10 obese nonsurgery subjects were studied. The former group was examined 14 to 20 years after surgery, and was found to have lower mean plasminogen activator inhibitor type 1 (PAI-1) activity (8.4 v 32 U/mL, P < .001), tissue plasminogen activator (tPA) antigen concentrations (7.2 v 12 micrograms/L, P < .01), body mass index (BMI), and fasting plasma insulin, triglyceride, and cholesterol levels. The PAI-1 levels were correlated with BMI, waist to hip ratio, and insulin, triglyceride, and cholesterol levels. Thus, previously obese subjects have normal PAI levels 14 to 20 years after treatment with JIB surgery, in contrast to the high PAI-1 levels in nonsurgery obese subjects.
Sylvan
A
A
Department of Surgery, Umeå University Hospital, Sweden.
Rutegård
J N
JN
Janunger
K G
KG
Sjölund
B
B
Nilsson
T K
TK
D000005:Abdomen / Q000033:anatomy & histology; D000328:Adult; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D002784:Cholesterol / Q000097:blood; D005500:Follow-Up Studies; D006615:Hip / Q000033:anatomy & histology; D006801:Humans; D007328:Insulin / Q000097:blood; D007581:Jejunoileal Bypass; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood* / Q000503:physiopathology / Q000601:surgery*; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D015849:Plasminogen Inactivators / Q000097:blood*; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000097:blood; D014280:Triglycerides / Q000097:blood
D007328:Insulin; D017395:Plasminogen Activator Inhibitor 1; D015849:Plasminogen Inactivators; D014280:Triglycerides; D002784:Cholesterol; D010959:Tissue Plasminogen Activator