The acute effect of a single very high dose of N-3 fatty acids on coagulation and fibrinolysis.
The objective of the study was to investigate the acute effect of a single very high dose of n-3 PUFA on coagulation and fibrinolysis. Forty healthy volunteers were randomized into two groups to receive either 20 grams of n-3 PUFA or 20 grams of n-6 PUFA as a single dose at 6 p.m. with their evening meal. Coagulation and fibrinolysis were evaluated in the fasting state at 8 a.m. the next morning and compared to values obtained at 8 a.m. the day before, when the participants were on their habitual diets. PAI-1 activity in plasma increased by a mean of 62% in subjects randomized to receive n-3 PUFA despite that no changes could be demonstrated in t-PA antigen levels. PAI-1 activity was unaltered in the 20 controls receiving n-6 PUFA. Plasma fibrinogen, coagulation factor VII, thrombin-antithrombin complexes and D-dimer did not significantly change after either supplement. The substantial increase in levels of PAI-1 activity in plasma after a single very high dose of n-3 PUFA may limit the usefulness of single very high doses of n-3 PUFA in acute clinical conditions.
Møller
J M
JM
Department of Endocrinology, Aalborg Hospital, Copenhagen.
Svaneborg
N
N
Lervang
H H
HH
Varming
K
K
Madsen
P
P
Dyerberg
J
J
Schmidt
E B
EB
D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects*; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000032:analysis*; D010959:Tissue Plasminogen Activator / Q000032:analysis
D015525:Fatty Acids, Omega-3; D017395:Plasminogen Activator Inhibitor 1; D010959:Tissue Plasminogen Activator