Effect of airway blood flow on airflow.
Resistance to gas flow of an airway is a function of both airway smooth muscle tone and thickness of the airway wall internal to the outer ring of airway smooth muscle. Schematically, the increase in airway resistance caused by shortening of airway smooth muscle may be potentiated by a concomitant increase in airway wall thickness caused by vasodilation of the bronchial vessels and/or microvascular leakage. Conversely, bronchial vasoconstriction may limit to some extent the increase in resistance to gas flow caused by airway smooth muscle shortening and/or congestion and edema of the airway wall. Many endogenous paracrine mediators, putatively involved in asthma and bronchial hyperresponsiveness, have both bronchomotor and vascular effects. The overall effects on resistance to airflow of endogenous or exogenous agents depend not only upon pre-existing airway smooth muscle tone and pre-existing condition of bronchial vessels but also upon two factors that facilitate microvascular leakage, namely, inflammation of the airway wall and outflow pressure of the bronchial circulation, which is close to left atrial pressure.
Lockhart
A
A
Laboratoire de Physiologie Respiratoire, Faculté de Médecine Cochin Port-Royal, Paris, France.
Dinh-Xuan
A T
AT
Regnard
J
J
Cabanes
L
L
Matran
R
R
D000402:Airway Obstruction / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D000403:Airway Resistance / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001249:Asthma / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D001783:Blood Flow Velocity; D004285:Dogs; D006333:Heart Failure / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D009130:Muscle, Smooth / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D011652:Pulmonary Circulation / Q000187:drug effects / Q000502:physiology; D012756:Sheep; D013552:Swine; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology