[Allergy to casein hydrolysate formula. A study of sensitizing allergen].
A six-month old baby, who had been fed for 2 months with casein hydrolysate formula (MA-1) for treatment of milk allergy, developed diarrhea. The baby's RAST score for milk was negative. IgE antibodies to MA-1 but not to MA-1 depleted of lipid (fat-free MA-1), were demonstrated by enzyme-linked immunosorbent assay (ELISA). It was confirmed by the appearance of numerous mast cells and eosinophils in a rectal smear taken after challenge with MA-1 (but not detected after challenge with fat-free MA-1) that some component in the lipid of MA-1 must be an allergen in this patient.
Shimojo
N
N
Department of Pediatrics, Chiba University School of Medicine.
Shimizu
N
N
Hirano
K
K
Kohno
Y
Y
Niimi
H
H
D002364:Caseins / Q000276:immunology*; D003108:Colonic Diseases / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D007223:Infant; D007225:Infant Food; D008297:Male; D016269:Milk Hypersensitivity / Q000276:immunology*; D011852:Radioallergosorbent Test
D002364:Caseins; D007073:Immunoglobulin E