title: [Derivatives of arteannuin B with antileukemia activity].
abstract: Arteannuin B (I) was converted to hydroxy lactones (VII, VIII) by a mixture of formic acid and sulfuric acid. Compound VI and Compound VII both showed activity against leukemia P 388 cell in vitro. The rate of growth inhibition were 97.5% and 11.8% for (VI) and 80% and 52.6% for (VII) at the concentration of 10 and 1 micrograms/ml respectively. It seems that the antileukemia activity of 6-membered lactone is higher than that of 5-membered and the methylene group is necessary for the antileukemia activity.
authors.affiliation: Academia Sinica, Shanghai Institute of Materia Medica.
authors.forename: D A
authors.initials: DA
authors.lastname: Deng
authors.forename: C H
authors.initials: CH
authors.lastname: Xu
authors.forename: J C
authors.initials: JC
authors.lastname: Cai
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology; D037621:Artemisinins; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D007941:Leukemia P388 / Q000473:pathology; D051379:Mice; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D037621:Artemisinins; D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes; C006634:arteannuin B