title: The effects of pyridostigmine bromide on visual performance.
abstract: The effects of pyridostigmine bromide (PB) on selected visual functions were measured on four healthy aviator candidates. Following a pretreatment day during which baseline measurements were completed, subjects were administered currently recommended doses (30 mg, t.i.d.) of PB for 3 d during which their visual functions were assessed using a repeated measures design. Spatial resolution ability was evaluated with high and low contrast visual acuity charts and contrast sensitivity charts at three luminance levels. Dark adaptation was evaluated by measuring visual thresholds for 40 min after a standardized retinal photopigment bleach. Also, refractive error and several oculomotor functions (lateral phoria, fusional vergence, accommodative amplitude, and pupil size) were measured. On days that the subjects ingested PB, only refractive error and pupil diameter were significantly different, and these only minimally. We conclude that the use of PB at doctrinal doses will not significantly compromise an aviator's visual ability.
authors.affiliation: Sensory Research Division, U.S. Army Aeromedical Research Laboratory, Fort Rucker, AL 36362-5292.
authors.forename: R W
authors.initials: RW
authors.lastname: Wiley
authors.forename: J C
authors.initials: JC
authors.lastname: Kotulak
authors.forename: I
authors.initials: I
authors.lastname: Behar
mesh_terms: D000065:Accommodation, Ocular / Q000187:drug effects; D000328:Adult; D015350:Contrast Sensitivity / Q000187:drug effects; D003290:Convergence, Ocular / Q000187:drug effects; D003623:Dark Adaptation / Q000187:drug effects; D005133:Eye Movements / Q000187:drug effects; D006801:Humans; D008297:Male; D008889:Military Personnel; D010275:Parasympathetic Nervous System / Q000187:drug effects; D011601:Psychophysics; D011729:Pyridostigmine Bromide / Q000494:pharmacology*; D012025:Reflex, Pupillary / Q000187:drug effects; D012029:Refraction, Ocular; D012684:Sensory Thresholds / Q000187:drug effects; D014787:Vision Tests; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D011729:Pyridostigmine Bromide