title: [Clinical significance of the measurement of serum pepsinogen group I and II by enzyme-linked immunosorbent assay].
abstract: We have developed enzyme-linked immunosorbent assay (ELISA) for pepsinogen group I and II (PG I.II) in human serum, and clinical significance of serum pepsinogen measurement was evaluated. Serum PG I.II levels in patients with gastric and duodenal ulcer were higher than those in normal healthy subjects. On the other hand, serum PG I levels in patients with pernicious anemia were significantly low levels. In both gastric ulcer and duodenal ulcer, serum PG I.II levels at active stage were higher than healing stage. These results suggested that the measurement of PG I.II levels was useful for screening or monitoring test for the injury of gastric and duodenal mucosa.
authors.affiliation: Japan Medical Institute of Clinical Laboratory Examination, Suita.
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
authors.forename: T
authors.initials: T
authors.lastname: Samori
authors.forename: M
authors.initials: M
authors.lastname: Taniguchi
authors.forename: K
authors.initials: K
authors.lastname: Kotera
authors.forename: S
authors.initials: S
authors.lastname: Nishi
authors.forename: M
authors.initials: M
authors.lastname: Takatsuji
authors.forename: K
authors.initials: K
authors.lastname: Higashi
authors.forename: K
authors.initials: K
authors.lastname: Itoh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010435:Pepsinogens / Q000097:blood* / Q000145:classification; D010437:Peptic Ulcer / Q000175:diagnosis / Q000201:enzymology
chemical_list: D015415:Biomarkers; D010435:Pepsinogens