Plasma catecholamine responses to dynamic exercise in patients with coronary artery disease--the relationship between sympathetic activity and systolic blood pressure and exercise-induced ventricular arrhythmias.
In order to investigate the relationship between sympathetic activity and postexercise systolic blood pressure (SBP) and exercise-induced ventricular arrhythmias in patients with coronary artery disease (CAD), we studied 38 patients and 9 normal subjects who underwent treadmill testing. Peak pressure-rate product was similar in the 2 groups. The plasma concentrations of norepinephrine and epinephrine at rest and immediately after exercise were significantly higher in patients with CAD compared with normal subjects (norepinephrine at rest, p < 0.01; norepinephrine immediately after exercise, p < 0.05; epinephrine at rest, p < 0.05; epinephrine immediately after exercise, p < 0.05). The level of norepinephrine immediately after exercise was significantly higher in 15 patients with a postexercise SBP increase than in 23 patients without that SBP change (p < 0.05), whereas the level of epinephrine was similar in the 2 groups. The level of epinephrine immediately after exercise was significantly higher in 10 patients with exercise-induced premature ventricular contractions than in 28 patients without those arrhythmias (p < 0.05), whereas the level of norepinephrine was similar in the 2 groups. We conclude that a postexercise SBP increase is related to the augmentation of sympathoneural activity and that exercise-induced ventricular arrhythmias are related to the augmentation of sympathoadrenal activity.
Miyakoda
H
H
First Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan.
Noguchi
N
N
Matsumoto
T
T
Kitamura
H
H
Kinugawa
T
T
Ogino
K
K
Hoshio
A
A
Kotake
H
H
Mashiba
H
H
D001145:Arrhythmias, Cardiac / Q000209:etiology*; D001794:Blood Pressure / Q000502:physiology*; D003327:Coronary Disease / Q000097:blood / Q000503:physiopathology*; D004837:Epinephrine / Q000097:blood*; D015444:Exercise; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood*; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D009638:Norepinephrine; D004837:Epinephrine