Diterpene metabolites from two chemotypes of the marine sponge Myrmekioderma styx.
Three apparent chemotypes of the marine sponge Myrmekioderma styx exist. An acyclic diterpene, styxenol A [1], has been isolated from the shallow water chemotype, while three tricarbocyclic diterpenes 3, 6, and 7 have been isolated from the deep chemotype. The structures were elucidated based on spectral methods including homo- and hetero-nuclear 2D nmr experiments. Compounds 1, 3, and 6 exhibit moderate cytotoxicity against the P-388 murine leukemia cell line and the A549 human lung tumor cell line.
Sennett
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Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Ft. Pierce, Florida 34946.
Pomponi
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Wright
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D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D008175:Lung Neoplasms / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D011161:Porifera / Q000737:chemistry* / Q000378:metabolism
D000970:Antineoplastic Agents; D004224:Diterpenes