title: Inflammatory cell infiltrate in the cervix as a predictor of residual cervical intraepithelial neoplasia after conization.
abstract: From January 1985 to January 1991, 112 patients underwent conization of the cervix for dysplasia. Twenty-one had incomplete resection, with cervical intraepithelial neoplasia (CIN) extending to the endocervical margins of resection. Only 10 had persistent CIN in follow-up. A decrease in the inflammatory cell infiltrate in the cervical stroma of the conization specimen was associated with persistent disease. A simple technique for quantitating this inflammatory cell infiltrate was used. Smoking was associated with a suppression of this local immune response in the cervix.
authors.affiliation: Department of Obstetrics and Gynecology, Marietta Memorial Hospital, Ohio.
authors.forename: C D
authors.initials: CD
authors.lastname: White
authors.forename: F R
authors.initials: FR
authors.lastname: Macatol
authors.forename: A B
authors.initials: AB
authors.lastname: DeJosef
mesh_terms: D000328:Adult; D001706:Biopsy; D002278:Carcinoma in Situ / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D009365:Neoplasm Regression, Spontaneous / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery; D002575:Uterine Cervicitis / Q000473:pathology*