title: [Zymogenic cell mass and serum pepsinogen I: the cell secretory correlations in patients with gastric intestinal-type cancer of the corpus-fundus].
abstract: The chief cell mass and serum pepsinogen I (PGI) have been evaluated in 18 patients with gastric cancer of intestinal type of the body-fundus. Moreover, a correlation with the parietal cell mass and the maximal acid output it has been effected. The patients have been subdivided in relation to histologic condition of the fundic mucosa. In case of gastric cancer with preatrophic fundic gastritis it has been revealed hypozymogenism with normoPGI and hypoparietalism with hypochlorhydria, in case of gastric cancer with atrophic fundic gastritis it has been revealed hypozymogenism with hypoPGI and hypoparietalism with hypochlorhydria. From this experience it emerges a similar anatomic-functional profile between gastric cancer of the body-fundus and chronic fundic gastritis without cancer. In particular, it emerges that serum PGI is a good marker of atrophic fundic gastritis, but it is not discriminant between atrophic fundic gastritis and atrophic fundic gastritis associated to gastric cancer.
authors.affiliation: Divisione di Gastroenterologia ed Endoscopia Digestiva, Ospedale S. Martino, Genova.
authors.forename: G
authors.initials: G
authors.lastname: Testino
authors.forename: A
authors.initials: A
authors.lastname: Perasso
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D000368:Aged; D002452:Cell Count; D004792:Enzyme Precursors / Q000378:metabolism*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005748:Gastric Fundus; D005757:Gastritis, Atrophic / Q000097:blood / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010295:Parietal Cells, Gastric / Q000378:metabolism* / Q000473:pathology; D010435:Pepsinogens / Q000097:blood*; D011230:Precancerous Conditions / Q000097:blood / Q000378:metabolism / Q000473:pathology; D013274:Stomach Neoplasms / Q000097:blood / Q000378:metabolism* / Q000473:pathology
chemical_list: D004792:Enzyme Precursors; D010435:Pepsinogens
vernacular_title: Massa cellulare zimogenica e pepsinogeno I sierico: correlazioni citosecretorie in pazienti con cancro gastrico di tipo intestinale del corpo-fundus.