Conferencia Cotzias de 1991 de la Sociedad Española de Neurologá. The genetic etiology of Parkinson's disease. A review of the evidence.
It has been amply documented that Lewy body PD can occur on genetic basis. The pedigrees described thus far have constantly shown an autosomal dominant pattern of inheritance. It remains to be determined what proportion of PD generally is familial? Accumulating clinical data indicate the proportion is quite large. The clinical data now available confirm the observations and conclusions of Mjones' pioneering study and are most consistent with the hypothesis that PD is an autosomal dominant disorder with reduced penetrance, markedly age-related expression and a broad range of clinical manifestations extending beyond our traditional clinical concepts of PD and including many atypical cases and formes frustes as Mjones had suggested. As a practical matter of research strategy the study of pedigrees offers the most promising approach available today to clarifying the etiology of PD for they make possible DNA linkage-mapping studies in search of gene loci.
Duvoisin
R C
RC
Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick.
D003863:Depression / Q000150:complications / Q000235:genetics; D004200:Diseases in Twins / Q000235:genetics; D006801:Humans; D010300:Parkinson Disease / Q000150:complications / Q000235:genetics* / Q000473:pathology; D010375:Pedigree; D012891:Sleep Apnea Syndromes / Q000150:complications / Q000235:genetics