Reaction in leprosy: acute phase reactant response during and after remission.
Sera from 25 patients with type 1 (Lepra), upgrading and downgrading, and type 2 (erythema nodosum leprosum [ENL]) reactions were assayed, during the reaction and after its clinical remission, for changes in levels of alpha-1-antitrypsin (A1A) and C-reactive protein (CRP). The results were compared with those from normal healthy adults and patients of leprosy without history and/or clinical evidence of reaction. The A1A levels correlated better with changes in status of type 1 reaction; whereas CRP levels correlated well with alterations in type 2 reactions and were definitely superior to A1A in this situation for monitoring the course of these episodes.
Sehgal
V N
VN
Department of Dermatology, Lady Hardinge Medical College, New Delhi, India.
Bhattacharya
S N
SN
Shah
Y
Y
Sharma
V K
VK
Gupta
C K
CK
D000293:Adolescent; D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D004893:Erythema Nodosum / Q000097:blood* / Q000628:therapy; D005260:Female; D006801:Humans; D015439:Leprosy, Borderline / Q000097:blood* / Q000276:immunology / Q000628:therapy; D015440:Leprosy, Lepromatous / Q000097:blood* / Q000276:immunology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011930:Reaction Time; D012074:Remission Induction; D000515:alpha 1-Antitrypsin / Q000378:metabolism
D000515:alpha 1-Antitrypsin; D002097:C-Reactive Protein