Accelerated growth in short children with chronic renal failure treated with both strict dietary therapy and recombinant growth hormone.
In a 12-month study, nine boys, aged 4.8-15.6 years, with bone ages 4.6-13 years, with moderate to severe chronic renal failure and resultant growth failure were treated with daily recombinant human growth hormone (rhGH), in conjunction with a strict low-protein/low-phosphate diet supplemented with keto and amino forms of the essential amino acids, histidine and additional energy. Improved growth had previously been observed with this dietary management over that obtained with conventional treatment for chronic renal failure. Each child had been on this diet for at least 2 years before rhGH was commenced. Mean height velocity increased from 4.6 +/- 1.3 to 9.0 +/- 1.3 cm/year (P < 0.001) in the pre-pubertal group, and in the pubertal group from 5.4 +/- 1.4 to 10.4 +/- 1.8 cm/year (P < 0.01). The mean height velocity standard deviation scores (SDSs) increased from -1.2 +/- 0.6 to +2.3 +/- 0.9 (P < 0.001) in the pre-pubertal group and from -0.4 +/- 0.6 to +1.9 +/- 1.1 (P < 0.01) in the pubertal group. Mean height SDS for chronological age increased from -2.2 +/- 0.7 to -1.5 +/- 0.5 (P < 0.01) in the pre-pubertal group and from -1.9 +/- 0.7 to -1.3 +/- 0.9 in the pubertal group (P < 0.02). There was no significant deterioration in renal function or renal bone disease, and bone age did not advance more than chronological age over the 12-month period.
van Renen
M J
MJ
Department of Nephrology, Adelaide Children's Hospital, South Australia.
Hogg
R J
RJ
Sweeney
A L
AL
Henning
P H
PH
Penfold
J L
JL
Jureidini
K F
KF
D000293:Adolescent; D000596:Amino Acids / Q000032:analysis; D001799:Blood Sedimentation; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000187:drug effects; D002118:Calcium / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003404:Creatinine / Q000652:urine; D004044:Dietary Proteins / Q000627:therapeutic use; D005527:Food, Fortified / Q000032:analysis*; D006128:Growth / Q000187:drug effects; D006130:Growth Disorders / Q000150:complications / Q000188:drug therapy*; D013006:Growth Hormone / Q000627:therapeutic use*; D006639:Histidine / Q000032:analysis; D006801:Humans; D007668:Kidney / Q000502:physiology; D007676:Kidney Failure, Chronic / Q000150:complications / Q000178:diet therapy* / Q000188:drug therapy*; D008297:Male; D016226:Phosphorus, Dietary / Q000627:therapeutic use; D011859:Radiography; D011994:Recombinant Proteins / Q000627:therapeutic use; D013223:Statistics as Topic; D013739:Testosterone / Q000097:blood; D014508:Urea / Q000652:urine
D000596:Amino Acids; D004044:Dietary Proteins; D016226:Phosphorus, Dietary; D011994:Recombinant Proteins; D013739:Testosterone; D006639:Histidine; D014508:Urea; D013006:Growth Hormone; D003404:Creatinine; D002118:Calcium