Abnormalities of chromosome 22 in meningiomas and confirmation of the origin of a dicentric 22 by in situ hybridization.
We report three cases of meningioma. Case 1 had a dicentric chromosome number 22 resulting in partial monosomy for a portion of the q-arm, i.e., 46,XX,idic(22)(pter-->q11.2::q11.2-->pter) and 46,XX,psu dic(22)(pter-->q11.2::q11.2-->pter), which was the sole clonal abnormality. The origin of the dicentric chromosome from 22 was confirmed by in situ hybridization studies, using biotin-labeled alpha centromeric DNA probes for the acrocentric chromosomes. Case 2 had two distinct clonal abnormalities: deletion of 22q and monosomy of 22. Case 3 also had a deleted 22q.
Tonk
V
V
Center for Human Genetics, Boston University School of Medicine, MA 02118.
Osella
P
P
Delasmorenas
A
A
Wyandt
H E
HE
Milunsky
A
A
D000368:Aged; D001932:Brain Neoplasms / Q000235:genetics; D002503:Centromere; D002872:Chromosome Deletion; D002892:Chromosomes, Human, Pair 22; D015342:DNA Probes; D005260:Female; D006258:Head and Neck Neoplasms / Q000235:genetics; D006801:Humans; D017403:In Situ Hybridization; D007621:Karyotyping; D008579:Meningioma / Q000235:genetics*; D008875:Middle Aged; D009006:Monosomy; D013120:Spinal Cord Neoplasms / Q000235:genetics
D015342:DNA Probes