trans-5-prostaglandin E2 stimulates plasminogen activation by tissue-type plasminogen activator.
The effect of trans-5-prostaglandin E2 (trans-PGE2) on fibrinolysis was examined in vitro using synthetic chromogenic substrate S-2251. trans-PGE2 was found to enhance plasminogen (PLG) activation mediated by tissue-type plasminogen activator (tPA). The enhancing effect was dependent on the concentration of trans-PGE2. cis-PGE2 and the other PGs (PGE1 and PGI2) did not show such an effect as trans-PGE2, despite to the fact that their structures are similar to that of trans-PGE2. trans-Configuration around the double bond at the 5-position seems to be important in the enhancement of the fibrinolytic activity.
Shimokawa
M
M
Department of Analytical Chemistry, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Urano
T
T
Kinoshita
T
T
D000595:Amino Acid Sequence; D002863:Chromogenic Compounds / Q000378:metabolism; D015232:Dinoprostone / Q000031:analogs & derivatives / Q000502:physiology*; D005342:Fibrinolysis / Q000187:drug effects; D007700:Kinetics; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000378:metabolism; D013379:Substrate Specificity; D010959:Tissue Plasminogen Activator / Q000502:physiology*
D002863:Chromogenic Compounds; D009842:Oligopeptides; C018788:valyl-leucyl-lysine 4-nitroanilide; D010959:Tissue Plasminogen Activator; D015232:Dinoprostone