Triptosine, an L-5-hydroxytryptophan derivative, reduces alcohol consumption in alcohol-preferring rats.
Triptosine is a new L-5-hydroxytryptophan derivative whose effect has been studied in the Long-Evans alcohol-preferring rat. At an oral dose of 100 mg/kg once daily, triptosine reduced alcohol consumption by 42% in the second week of treatment and increased that of water by 80%. The results suggest that this precursor of serotonin might play an important role in diminishing preference for alcohol and reaccustoming the animal to water, without exerting an anorexic effect.
Ernouf
D
D
U.F.R. de Pharmacie de Tours, St. Pierre-des-Corps, France.
Daoust
M
M
Poulain
D
D
Narcisse
G
G
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000077443:Acamprosate; D000427:Alcohol Deterrents / Q000494:pharmacology*; D000428:Alcohol Drinking / Q000503:physiopathology*; D000818:Animals; D001066:Appetite / Q000187:drug effects* / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D007288:Inosine / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000502:physiology; D012701:Serotonin / Q000502:physiology*; D013654:Taurine / Q000031:analogs & derivatives / Q000494:pharmacology
D000427:Alcohol Deterrents; D004338:Drug Combinations; D011985:Receptors, Serotonin; D013654:Taurine; D012701:Serotonin; D007288:Inosine; C078527:triptosine; D006916:5-Hydroxytryptophan; D000077443:Acamprosate