title: Trans-fatty acid intake in relation to serum lipid concentrations in adult men.
abstract: The relation of trans-fatty acid intake to fasting serum lipid concentrations was evaluated in a cross-sectional study of 748 men aged 43-85 y. Multiple-linear-regression analysis was used to adjust for age, body mass index, waist-to-hip circumference ratio, smoking status, physical activity, alcohol intake, total energy, dietary cholesterol and linoleic acid, and previous serum cholesterol concentration. Trans-fatty acid intake was directly related to total serum (r = 0.07, P = 0.04) and low-density-lipoprotein cholesterol (LDL) (r = 0.09, P = 0.01), and inversely related to high-density-lipoprotein (HDL) cholesterol (r = 0.08, P = 0.03). Trans-fatty acid intake was positively associated with the ratios of total to HDL cholesterol (r = 0.11, P = 0.002) and LDL to HDL cholesterol (r = 0.12, P = 0.001). The estimated ratios of total to HDL cholesterol were 4.4 and 4.9 for persons at the 10th (2.1 g/d) and 90th (4.9 g/d) percentiles of trans-fatty acid intake, respectively. On the basis of results from other studies, these ratios would correspond to a 27% increase in risk of myocardial infarction.
authors.affiliation: Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston 02115.
authors.forename: R
authors.initials: R
authors.lastname: Troisi
authors.forename: W C
authors.initials: WC
authors.lastname: Willett
authors.forename: S T
authors.initials: ST
authors.lastname: Weiss
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001824:Body Constitution; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage*; D002149:Energy Intake; D005227:Fatty Acids / Q000008:administration & dosage*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004041:Dietary Fats; D005227:Fatty Acids; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol