title: Value of MRI and MIBG-I123 scintigraphy in the diagnosis of spinal bone marrow involvement in neuroblastoma in children.
abstract: The results of MRI and MIBG scintigraphy performed on the spine of 14 children with neuroblastoma are reported. In 6 cases of diffuse spinal bone marrow tumor infiltration, diagnosis is easier with MIBG scintigraphy than with MRI. In 5 cases, MRI detected hyposignal of the vertebral body without any spinal abnormality on MIBG scintigraphy. A discussion of the reasons for negative MIBG scintigraphy is presented and in these 5 cases, it is suggested that a lateral view of MIBG scintigraphy and HMDP-Tc99m scintigraphy may be performed, even vertebral body biopsy in order to assess bone marrow tumoral infiltration.
authors.affiliation: Department of Pediatric Radiology, CHU Timone Hôpital d'Enfants, Marseille, France.
authors.forename: B
authors.initials: B
authors.lastname: Bourliere Najean
authors.forename: S
authors.initials: S
authors.lastname: Siles
authors.forename: M
authors.initials: M
authors.lastname: Panuel
authors.forename: S
authors.initials: S
authors.lastname: Cammilleri
authors.forename: F
authors.initials: F
authors.lastname: Faure
authors.forename: P
authors.initials: P
authors.lastname: Devred
authors.forename: G
authors.initials: G
authors.lastname: Kaphan
mesh_terms: D019797:3-Iodobenzylguanidine; D001853:Bone Marrow; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008279:Magnetic Resonance Imaging; D008297:Male; D009447:Neuroblastoma / Q000175:diagnosis*; D013125:Spinal Neoplasms / Q000175:diagnosis*
chemical_list: D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine