[Function, molecular structure and gene expression regulation of receptor for D-factor/LIF].
Differentiation-stimulating factor (D-factor)/leukemia inhibitory factor (LIF) is a cytokine inducing differentiation of mouse myeloid leukemic M1 cells. IL-6, oncostatin M (OSM) and G-CSF also induce differentiation of M1 cells. These four cytokines are suggested to be members of a single cytokine family. The LIF receptor is structurally related to the gp130 signal-transducing component of the IL-6 receptor and to the G-CSF receptor. The high-affinity receptors for LIF, OSM and IL-6 share the common subunit, gp130. This provides an explanation for the functional redundancy of those cytokines.
Tomida
M
M
Saitama Cancer Center Research Institute.
D000818:Animals; D006131:Growth Inhibitors / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D006801:Humans; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; D053680:Leukemia Inhibitory Factor Receptor alpha Subunit; D015470:Leukemia, Myeloid, Acute / Q000473:pathology; D008222:Lymphokines / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D051379:Mice; D015394:Molecular Structure; D008970:Molecular Weight; D018121:Receptors, Cytokine; D011971:Receptors, Immunologic / Q000502:physiology; D053606:Receptors, OSM-LIF; D015398:Signal Transduction
D006131:Growth Inhibitors; D015850:Interleukin-6; C507837:LIF protein, human; C507840:LIFR protein, human; D053605:Leukemia Inhibitory Factor; D053680:Leukemia Inhibitory Factor Receptor alpha Subunit; C507838:Lif protein, mouse; C507841:Lifr protein, mouse; D008222:Lymphokines; D018121:Receptors, Cytokine; D011971:Receptors, Immunologic; D053606:Receptors, OSM-LIF