[Preclinical study of the general toxic effect of polyplatillen].
Toxic action of polyplatillen, a principally new platinum compound, was studied on laboratory animals and cell culture. When compared with cis-dichlorodiamminplatinum, the preparation is 10-fold less toxic in animals and 100-fold--in the cellular systems. Reversibility of damaging action of polyplatillen at "non-toxic" dosages conditions the perspectiveness of its further clinical trials.
Shalimov
S A
SA
Keĭsevich
L V
LV
Trokhimenko
E P
EP
Dziublik
I V
IV
Volchenskova
I I
II
D000818:Animals; D002478:Cells, Cultured; D002945:Cisplatin / Q000008:administration & dosage / Q000633:toxicity*; D004285:Dogs; D051379:Mice; D051381:Rats
D002945:Cisplatin
Doklinicheskoe izuchenie obshchetoksicheskogo deĭstviia poliplatillena.