Effect of picroliv on glutathione metabolism in liver and brain of Mastomys natalensis infected with Plasmodium berghei.
Administration of picroliv, the active principle from Picrorhiza kurrooa, at a dose of 6 mg/kg, po for two weeks showed significant protection against changes in liver and brain glutathione metabolism of Plasmodium berghei infected Mastomys natalensis. The depletion of reduced glutathione level and inhibition of glutathione-S-transferase, glutathione reductase and glutathione peroxidase activities due to P. berghei infection were markedly recovered by picroliv. The increased levels of lipid peroxidation products in damaged tissues were also reduced along with the recovery of glutathione metabolism.
Chander
R
R
Biochemistry Division, Central Drug Research Institute, Lucknow, India.
Kapoor
N K
NK
Dhawan
B N
BN
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002934:Cinnamates / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism*; D006027:Glycosides / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000378:metabolism*; D008288:Malaria / Q000188:drug therapy*; D008297:Male; D009115:Muridae; D010936:Plant Extracts / Q000494:pharmacology*; D010962:Plasmodium berghei; D014641:Vanillic Acid / Q000494:pharmacology*
D002934:Cinnamates; D006027:Glycosides; D010936:Plant Extracts; C057463:kutkin; D005978:Glutathione; D014641:Vanillic Acid