title: CP-72,588, a semisynthetic analog of the polyether ionophore UK-58,582 with increased anticoccidial potency.
abstract: We have employed semisynthesis to enhance the anticoccidial potency of a polyether ionophore. CP-72,588 is the alpha-methyl analog of the fermentation-derived polyether ionophore UK-58,852. The parent ionophore required a dose of 15 ppm to achieve anticoccidial efficacy in chickens equivalent to that of salinomycin at 60 ppm. CP-72,588 demonstrated substantially improved potency, with efficacy at 5 to 7.5 ppm. The intrinsic antimicrobial potencies of the two ionophores are similar; however, CP-72,588 was found in chicken tissues at higher levels than those of the parent ionophore when each was administered at the same dose (8 ppm). The enhanced potency of CP-72,588 may be partially due to enhanced uptake into tissues.
authors.affiliation: Central Research Division, Pfizer Inc., Groton, Connecticut 06340.
authors.forename: A P
authors.initials: AP
authors.lastname: Ricketts
authors.forename: L R
authors.initials: LR
authors.lastname: Chappel
authors.forename: G M
authors.initials: GM
authors.lastname: Frame
authors.forename: E A
authors.initials: EA
authors.lastname: Glazer
authors.forename: T T
authors.initials: TT
authors.lastname: Migaki
authors.forename: J A
authors.initials: JA
authors.lastname: Olson
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002645:Chickens; D003048:Coccidiosis / Q000188:drug therapy*; D003049:Coccidiostats / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004539:Eimeria / Q000187:drug effects*; D004987:Ethers / Q000493:pharmacokinetics / Q000627:therapeutic use; D004988:Ethers, Cyclic / Q000493:pharmacokinetics / Q000627:therapeutic use*; D007476:Ionophores / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D003049:Coccidiostats; D004987:Ethers; D004988:Ethers, Cyclic; D007476:Ionophores; C072159:UK 58852; C078048:CP 72588