title: [Sublingual captopril in hypertensive crises].
abstract: Captopril is widely used in severe hypertension. Oral administration takes one-two hours to achieve a maximum effect and is not useful in hypertensive crisis. Few reports describe a more rapid effect on blood pressure following sublingual administration. We evaluated the effect of sublingual captopril 50 mg, in 26 patients with hypertensive crisis. Blood pressure levels started to decrease within 10 minutes and the maximum effect was observed 30 minutes after administration of the tablet. In all patients mean (CI 95%) systolic blood pressure dropped from 202.5 (199-206) mmHg to 160.6 (156-165) mmHg and diastolic blood pressure from 105.6 (102-109) mmHg to 86.9 (83-7-90.1) mmHg. This effect was maintained over two hours. There were no side effects. Sublingual captopril is highly effective in hypertensive crisis and its gradual hypotensive action avoid dangerous abrupt fall in blood pressure.
authors.affiliation: II Divisione di Medicina interna, Ospedale Castelnuovo, USL 16, Caltanissetta.
authors.forename: M
authors.initials: M
authors.lastname: Alletto
authors.forename: A
authors.initials: A
authors.lastname: Burgio
authors.forename: G
authors.initials: G
authors.lastname: Fulco
authors.forename: R
authors.initials: R
authors.lastname: Paradiso
authors.forename: M
authors.initials: M
authors.lastname: Piangiamore
authors.forename: F
authors.initials: F
authors.lastname: Vancheri
mesh_terms: D000286:Administration, Sublingual; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D002216:Captopril / Q000008:administration & dosage*; D005260:Female; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged
chemical_list: D002216:Captopril
vernacular_title: Captopril sublinguale nelle crisi ipertensive.