[Effects of blood-diltiazem-nitroglycerin-cardioplegia in coronary artery bypass grafting].
Forty-seven patients who underwent coronary artery bypass grafting using blood cardioplegia (BCP) were studied clinically. They were divided into 3 groups based on concentration of diltiazem (DTZ) and nitroglycerin (NTG). Group I (n = 12); DTZ 5 mg plus NTG 5 mg in BCP 1,000 ml, Group II (n = 10); NTG 25 mg in BCP 1,000 ml, Group III (n = 25); DTZ 5 mg plus NTG 25 mg in BCP 1,000 ml. From the standpoint of serum enzyme analysis, there was no significant difference between 3 groups, however, the incidence of perioperative myocardial infarction (PMI) and perioperative coronary spasm (PCS) were significantly higher in Group I than that in other groups. The present data suggests that intramyocardial concentration of NTG in Group II and III were 5 times higher than Group I. Increased dose of NTG in BCP would be benefit for myocardial protection in CABG.
Tanaka
T
T
Department of Surgery (Section 2), Sapporo Medical College.
Kazui
T
T
Komatsu
K
K
Sasaki
A
A
Inoue
N
N
Izumiyama
O
O
Yokoyama
H
H
Yamada
O
O
Komatsu
S
S
D000328:Adult; D000368:Aged; D001769:Blood; D002314:Cardioplegic Solutions; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000601:surgery*; D003329:Coronary Vasospasm / Q000517:prevention & control; D004110:Diltiazem / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000517:prevention & control; D005996:Nitroglycerin / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000517:prevention & control
D002314:Cardioplegic Solutions; D004110:Diltiazem; D005996:Nitroglycerin