title: [A case of adult onset hypophosphatemic vitamin D resistant osteomalacia].
abstract: A case of adult onset hypophosphatemic vitamin D resistant osteomalacia is described. A 40-year-old female who complained of thorax and lumbar pain and gait disturbance was admitted to our hospital on 7 November, 1988. The patient had hypophosphatemia with normal plasma calcium, parathyroid hormone and 25-hydroxy vitamin D3 concentrations, but had decreased tubular reabsorption of phosphate and decreased plasma 1, 25-dihydroxy vitamin D3 concentrations. The iliac crest bone biopsy showed osteomalacic changes. The 99mTc-MDP bone scintigram showed evidence of increased bone turnover with raised plasma alkaline phosphatase concentrations. After treatment with oral 1 alpha-hydroxy vitamin D3 (3-6 micrograms/day) and intravenous or oral phosphate supplement (0.47-1.74g/day), the subjective and clinical findings improved.
authors.affiliation: Second Department of Internal Medicine, Saitama Medical School.
authors.forename: T
authors.initials: T
authors.lastname: Katagiri
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Akiyama
authors.forename: T
authors.initials: T
authors.lastname: Ishibashi
authors.forename: K
authors.initials: K
authors.lastname: Hara
authors.forename: H
authors.initials: H
authors.lastname: Oka
authors.forename: T
authors.initials: T
authors.lastname: Imai
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: H
authors.initials: H
authors.lastname: Kitagawa
authors.forename: S
authors.initials: S
authors.lastname: Ohno
mesh_terms: D000328:Adult; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000627:therapeutic use; D010018:Osteomalacia / Q000097:blood / Q000188:drug therapy*; D010710:Phosphates / Q000097:blood* / Q000627:therapeutic use; D014807:Vitamin D / Q000627:therapeutic use*
chemical_list: D006887:Hydroxycholecalciferols; D010710:Phosphates; D014807:Vitamin D; C008088:alfacalcidol