[The efficacy of Augmentin in suppurative complications in neurosurgery].
The results of clinical and laboratory studies on the use of augmentin in severe purulent complications after neurosurgical operations are presented. The laboratory studies carried out with the use of an automatic system Cobas Bact (Roch) showed that the numbers of the augmentin resistant strains of Staphylococcus and Enterobacteriaceae among the pathogens were 47 and an average of 64.5%, respectively. Gram-negative bacteria resistant to augmentin were 1.5 to 2 times less frequent than those resistant to amoxycillin. Still, they were much more frequent than those resistant to cefotaxime and ceftriaxone. Clinical efficacy of augmentin was studied in treatment of 39 patients with various affections of the brain such as tumors, trauma, vascular malformations and inflammatory processes. The postoperative complications were represented by meningitis, pneumonia, sepsis and their associations. The use of augmentin in the severe intra- and extracranial complications was favourable in 82.1% of the cases.
Imshenetskaia
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D000658:Amoxicillin / Q000494:pharmacology / Q000627:therapeutic use*; D019980:Amoxicillin-Potassium Clavulanate Combination; D001419:Bacteria / Q000187:drug effects; D001921:Brain / Q000601:surgery*; D001930:Brain Injuries / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D002969:Clavulanic Acids / Q000494:pharmacology / Q000627:therapeutic use*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008826:Microbial Sensitivity Tests; D013530:Surgical Wound Infection / Q000188:drug therapy* / Q000382:microbiology; D014946:Wound Infection / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology
D002969:Clavulanic Acids; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin
Effektivnost' Augmentina pri gnoĭnykh oslozhneniiakh v neĭrokhirurgii.