Relationship between serum lipid peroxidation products in hypercholesterolemic subjects and vitamin E status.
The relationship of serum lipid peroxidation products in hypercholesterolemic subjects to their vitamin E intake was examined in 15 such subjects with no other associated significant disease process in a 3 month trial with vitamin E supplementation. These patients with elevated serum cholesterol levels also have elevated thiobarbituric acid reactive substances (TBARS) and lipid oxidation products (LOPS). Vitamin E supplementation of 800 IU daily normalized the lipid peroxidation products but did not significantly change serum lipids.
Bierenbaum
M L
ML
Kenneth L. Jordan Heart Fund, Montclair, New Jersey 07042.
Reichstein
R P
RP
Bhagavan
H N
HN
Watkins
T R
TR
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism; D002338:Carotenoids / Q000097:blood; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood* / Q000188:drug therapy*; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000097:blood*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014810:Vitamin E / Q000097:blood / Q000627:therapeutic use*; D019207:beta Carotene
D000975:Antioxidants; D008054:Lipid Peroxides; D008055:Lipids; D017392:Thiobarbituric Acid Reactive Substances; D019207:beta Carotene; D014810:Vitamin E; D002338:Carotenoids