title: The effect of partial hepatectomy on the genotoxicity of aflatoxin B1. II.
abstract: The influence of partial hepatectomy (PH) on the genotoxic effect of aflatoxin B1 (AFB1) mycotoxin in male Chinese hamsters (Cricetulus griseus) in vivo was studied after a repeated i.p. application of small doses of AFB1 during 8 weeks. The frequency of aberrant cells did not increase after repeated application and persisted throughout the whole period on a relatively stable level. No cumulative genotoxic effect of repeated doses of AFB1 was observed. PH decreased the genotoxic effect of AFB1 only in week 4, while in weeks 6 and 8 no significant differences between hepatectomized and nonhepatectomized animals were recorded.
authors.affiliation: National Institute of Public Health, Prague, Czechoslovakia.
authors.forename: T
authors.initials: T
authors.lastname: Petr
authors.forename: I
authors.initials: I
authors.lastname: Bárta
authors.forename: M
authors.initials: M
authors.lastname: Adámková
authors.forename: P
authors.initials: P
authors.lastname: Hrabal
mesh_terms: D016604:Aflatoxin B1 / Q000633:toxicity*; D000818:Animals; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D006498:Hepatectomy; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male
chemical_list: D016604:Aflatoxin B1