Gamma-glutamyltaurine has potent and long-lasting antiepileptic action as demonstrated by intra-amygdaloid injection in amygdala-kindled rats.
Intra-amygdaloid injections of gamma-glutamyltaurine, a recently identified brain dipeptide, strongly suppressed seizures in amygdala-kindled rats stimulated with intensities 10 or 50 microA above the generalized seizure triggering threshold (mean 82 microA). The suppressive effect persisted as long as 3 days. Taurine had relatively weak suppressive effects. Thus gamma-glutamyltaurine seems much more potent than taurine in the suppression of epileptic seizures when injected directly into the kindling site.
Uemura
S
S
Division of Neuroanatomy, Shiga University of Medical Science, Otsu, Japan.
Ienaga
K
K
Higashiura
K
K
Kimura
H
H
D000679:Amygdala / Q000187:drug effects*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D005973:Glutamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007267:Injections; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D009479:Neuropeptides / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013654:Taurine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013997:Time Factors
D000927:Anticonvulsants; D009479:Neuropeptides; D005973:Glutamine; D013654:Taurine; C020903:glutaurine