The spectrum of presentation at autopsy of myocarditis in infancy and childhood.
To characterize the clinicopathological presentation of patients with myocarditis coming to autopsy in childhood, 32 cases of histologically-proven myocarditis were obtained from the files of the Adelaide Children's Hospital. In 16 of the cases (Group A), myocarditis was the only significant finding and death was ascribed to this condition. In the remaining 16 (Group B) myocarditis was found in association with other severe disease processes. Clinical histories of the 2 groups showed sudden death to be a feature in 5 out of 16 cases in Group A, 3 of whom had no prodromal symptoms. Five patients in Group B also suffered sudden death, but this was associated with a variety of causes, including bronchopneumonia, and asphyxia. These cases demonstrate the variability in clinicopathological presentation of myocarditis in infancy and childhood and suggest that myocarditis should always be considered a possible diagnosis at autopsy in the pediatric age group, even in the presence of coincident lethal disease.
Smith
N M
NM
Department of Histopathology, Adelaide Children's Hospital, South Australia.
Bourne
A J
AJ
Clapton
W K
WK
Byard
R W
RW
D000293:Adolescent; D001344:Autopsy; D002644:Chickenpox / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D003384:Coxsackievirus Infections / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009205:Myocarditis / Q000382:microbiology / Q000473:pathology*; D009206:Myocardium / Q000473:pathology