Remnant atrial function in human and animal recipients of a total artificial heart.
The native atria remains intact after total artificial heart (TAH) implantation. The electrical activity of the recipient's atria can be recorded from wires placed during TAH implantation. Regulating TAH heart rate by coupling it with native atrial activity has the potential for a more physiologically responsive TAH. The reactivity of the atrial impulse rate is a critical component of this link, but little is known about atrial responsiveness after TAH placement. Two human and three animal TAH recipients had recordable atrial electrical activity. Human atrial impulse rate after TAH was relatively constant at rest but unresponsive to physiologic stimuli. Analysis of human atrial contraction provided no discernable effect on ventricular filling. Animal atrial impulse rate at rest was more rapid than calves without a TAH. The bovine TAH recipients had an atrial impulse rate that responded to catecholamine stimulation and blockade. Isoproterenol caused a significant rise in atrial impulse rate (152 +/- 16 impulses per minute to 216 +/- 24 impulses per minute; p < 0.05) and propranolol caused a decrease in atrial impulse rate (142 +/- 20 impulses per minute to 122 +/- 19 impulses per minute; p > 0.05). Despite beta blockade, the atrial impulse rate remained abnormally elevated secondary to unknown factors. Animal atrial contraction did appear to intermittently augment TAH ventricular filling. These data indicate that the atria remains electrically intact after TAH implantation. The human atrial impulse rate was unresponsive to physiologic stimuli although the animal atrial impulse rate was affected by exogenous catecholamine administration, but the rate remained abnormally rapid.(ABSTRACT TRUNCATED AT 250 WORDS)
Murray
K D
KD
Ohio State University Hospitals, Division of Thoracic and Cardiovascular Surgery, Columbus 43210.
Binkley
P F
PF
Watson
K M
KM
Howanitz
E P
EP
Ross
P
P
Myerowitz
P D
PD
D000818:Animals; D016275:Atrial Function / Q000502:physiology*; D009202:Cardiomyopathies / Q000601:surgery; D002417:Cattle; D004562:Electrocardiography; D004567:Electrodes, Implanted; D006339:Heart Rate / Q000502:physiology; D006354:Heart, Artificial; D006801:Humans; D007545:Isoproterenol / Q000627:therapeutic use; D009200:Myocardial Contraction / Q000502:physiology; D011187:Posture / Q000502:physiology; D011433:Propranolol / Q000627:therapeutic use; D012307:Risk Factors; D014636:Valsalva Maneuver / Q000502:physiology
D011433:Propranolol; D007545:Isoproterenol