title: [Synthesis and pharmacology of structural analogs of tienilic acids].
abstract: Three structural analogs of tienilic acid were synthetized and evaluated for their diuretic activity in the rat. Two compounds are alpha substituted tienilic acid derivatives by an alkylated group. The third one is a conformationally restricted derivative through a cyclization process. All compounds fall to increase the urinary flow in the pharmacological assay.
authors.affiliation: Département de Chimie Pharmaceutique, Faculté de Pharmacie, Toulouse.
authors.forename: G
authors.initials: G
authors.lastname: de Saqui-Sannes
authors.forename: G
authors.initials: G
authors.lastname: Baziard-Mouysset
authors.forename: M
authors.initials: M
authors.lastname: Payard
authors.forename: P
authors.initials: P
authors.lastname: Tronche
authors.forename: A
authors.initials: A
authors.lastname: Auriac
authors.forename: G
authors.initials: G
authors.lastname: Roux
mesh_terms: D000818:Animals; D004232:Diuretics / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013989:Ticrynafen / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D004232:Diuretics; D013989:Ticrynafen
vernacular_title: Synthèse et approche pharmacologique d'analogues structuraux de l'acide tiénilique.