title: Marked eosinophilia induced by nafamostat mesilate, an anticoagulant in a hemodialysis patient.
abstract: A 61-year-old Japanese female on hemodialysis developed marked eosinophilia induced by nafamostat mesilate as an anticoagulant for hemodialysis. This is the first case of hypereosinophilic syndrome induced by nafamostat mesilate in a hemodialysis patient. The elevated eosinophil counts (51,900/mm3) are the highest for hemodialysis-associated eosinophilia. This eosinophilia was eliminated after cessation of nafamostat mesilate. We confirmed that the cause of this eosinophilia was nafamostat mesilate by using the challenge test.
authors.affiliation: Department of Internal Medicine, Osaka National Hospital, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nakanishi
authors.forename: T
authors.initials: T
authors.lastname: Kaneko
authors.forename: F
authors.initials: F
authors.lastname: Yano
authors.forename: M
authors.initials: M
authors.lastname: Horio
authors.forename: H
authors.initials: H
authors.lastname: Kawagoe
authors.forename: M
authors.initials: M
authors.lastname: Fujii
authors.forename: K
authors.initials: K
authors.lastname: Kashiwai
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects*; D001550:Benzamidines; D004802:Eosinophilia / Q000139:chemically induced*; D005260:Female; D006146:Guanidines / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D006435:Renal Dialysis
chemical_list: D000925:Anticoagulants; D001550:Benzamidines; D006146:Guanidines; C032855:nafamostat