[Immunopathologic study of the myocardium in dilated cardiomyopathy].
Myocardial tissues of patients with dilated cardiomyopathy were studied by immunofluorescence. While immunoglobulin A fixation was observed in myocardial capillary wall and cardiomyocyte sarcolemma in the majority of patients (11 of 12), immunoglobulin G and C3 complement component were a rare finding. In the vessel wall of heart allografts immunoglobulin A fixation occurred 3-6 days after transplantation. As a result of the intensive immunosuppressive therapy which was used after the operation immunoglobulin A disappeared from heart allografts within 4-5 weeks. Immunoglobulin A fixation in the heart of patients with dilated cardiomyopathy is attributed to the anti-tissue or antivirus antibodies and probably is involved in the development of this disease.
Beletskaia
L V
LV
Baranova
F S
FS
Mogilevskiĭ
G M
GM
Kurenkova
L G
LG
Kazakov
E N
EN
Kormer
A Ia
AIa
Smirnova
I V
IV
Khalimova
Z A
ZA
Dmitriev
A A
AA
Chestukhin
V V
VV
D001706:Biopsy; D002311:Cardiomyopathy, Dilated / Q000276:immunology / Q000473:pathology*; D003176:Complement C3 / Q000032:analysis; D005455:Fluorescent Antibody Technique; D016027:Heart Transplantation / Q000473:pathology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D014184:Transplantation, Homologous
D003176:Complement C3; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents
Immunopatologicheskoe issledovanie miokarda pri diliatatsionnoĭ kardiomiopatii.