Serum amino acid levels and hepatic protein synthesis during liver regeneration after partial hepatectomy in rats.
The time courses of changes in serum concentrations of free amino acids and in hepatic protein synthesis during liver regeneration after partial hepatectomy were studied in rats. Hepatic protein synthesis was significantly higher 3, 5 and 7 days after partial hepatectomy than it was in sham-operated control rats, but there was no such difference 14 days after surgery. Serum total amino acid level was significantly higher in partially-hepatectomized rats than in control rats 3 days after surgery, and thereafter decreased slowly. By 7 days after surgery there was no significant difference between the two groups. Serum concentrations of threonine, serine, proline, histidine, tyrosine, methionine, ornithine and citrulline were significantly higher than in the control group 3 days after partial hepatectomy, and the concentrations of proline, histidine, tyrosine, methionine and ornithine were still high 5 days after surgery. In contrast, concentrations of branched-chain amino acids did not change.
Murawaki
Y
Y
Second Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan.
Ikuta
Y
Y
Yamamoto
H
H
Kawasaki
H
H
D000596:Amino Acids / Q000097:blood*; D000818:Animals; D006498:Hepatectomy; D008099:Liver / Q000378:metabolism; D008115:Liver Regeneration / Q000502:physiology*; D008297:Male; D011392:Proline / Q000097:blood; D014176:Protein Biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000596:Amino Acids; D011392:Proline