title: Interferon-mediated intracellular signalling. Modulation of different phospholipase activities in Burkitt lymphoma cells.
abstract: The effect of interferon-alpha on Daudi lymphoma cells either sensitive or resistant to the action of this cytokine has been analysed in terms of phospholipase C (PLC) and D (PLD) activities. Results have shown a combined modulation of PIP2-specific phospholipase C and phospholipase D. In particular, a decreased activity of PIP2-specific PLC has been found, concomitant to a PLD-mediated phosphatidylcholine hydrolysis, suggesting that the intracellular signalling activated by interferon in Daudi cells involves a phospholipase D/phosphohydrolase pathway.
authors.affiliation: Istituto di Morfologia Umana Normale, Università di Chieti, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Cataldi
authors.forename: R
authors.initials: R
authors.lastname: Rana
authors.forename: R
authors.initials: R
authors.lastname: di Primio
authors.forename: R
authors.initials: R
authors.lastname: Bareggi
authors.forename: R
authors.initials: R
authors.lastname: Lisio
authors.forename: N
authors.initials: N
authors.lastname: Toto
authors.forename: S
authors.initials: S
authors.lastname: Miscia
mesh_terms: D002051:Burkitt Lymphoma / Q000201:enzymology; D004075:Diglycerides / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000494:pharmacology*; D010712:Phosphatidic Acids / Q000378:metabolism; D010739:Phospholipase D / Q000378:metabolism*; D011433:Propranolol / Q000494:pharmacology; D011994:Recombinant Proteins; D015398:Signal Transduction; D014407:Tumor Cells, Cultured; D010738:Type C Phospholipases / Q000378:metabolism*
chemical_list: D004075:Diglycerides; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D010712:Phosphatidic Acids; D011994:Recombinant Proteins; D011433:Propranolol; D010738:Type C Phospholipases; D010739:Phospholipase D