Acute alcohol intoxication, body composition, and pharmacokinetics.
The present study compared alcohol pharmacokinetics associated with body weight, anthropometrically estimated total body water, and body mass index in men and women in two experimental sessions, single dose and double dose. All subjects were given the same amount of alcohol (2.3 and 4.6 oz. 86 proof vodka for single dose and double dose, respectively). Data analyses found a significant correlation between body mass index and peak blood alcohol concentration (BAC). Weight and total body water were not significantly correlated with peak BAC. The findings suggested that body mass index may be considered a better criterion than body weight for equating alcohol doses.
Wang
M Q
MQ
Health and Human Performance Studies, University of Alabama, Tuscaloosa 35487.
Nicholson
M E
ME
Jones
C S
CS
Fitzhugh
E C
EC
Westerfield
C R
CR
D000328:Adult; D000435:Alcoholic Intoxication / Q000378:metabolism*; D001823:Body Composition / Q000502:physiology*; D001827:Body Height; D001834:Body Water / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D000431:Ethanol / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D012727:Sex Characteristics
D000431:Ethanol