title: beta-lactamases in Shigella.
abstract: The occurrence of resistance and production of beta-lactamases was investigated in 60 Shigella strains. Ampicillin resistance was found in 28 (47%) of the isolates, the resistance being more frequent in Sh. flexneri than in Sh. sonnei. All strains were susceptible to cefotaxime, mecillinam, and ciprofloxacin. The beta-lactamases produced by Shigella were similar to TEM-1, OXA-1, or the low-level chromosomally mediated cephalosporinase produced by Escherichia coli. The beta-lactamases produced by Sh. flexneri were most often the OXA-1-like enzymes.
authors.affiliation: Department of Hospital Infections and Antibiotics, Statens Seruminstitut, Copenhagen, Denmark.
authors.forename: H
authors.initials: H
authors.lastname: Schumacher
authors.forename: M
authors.initials: M
authors.lastname: Nir
authors.forename: B
authors.initials: B
authors.lastname: Mansa
authors.forename: A
authors.initials: A
authors.lastname: Grassy
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D012760:Shigella / Q000187:drug effects / Q000201:enzymology*; D001618:beta-Lactamases / Q000032:analysis* / Q000096:biosynthesis
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases