Intracerebroventricular neuropeptide Y stimulates bile secretion via a vagal mechanism.
The effect of intracerebroventricular injection of neuropeptide Y on biliary secretion was studied in conscious dogs, prepared with gastric and duodenal fistulas and cerebroventricular guides. Bile secretion was increased in a dose-dependent fashion by intracerebroventricular neuropeptide Y. The peak increase was seen after 500 pM/kg of neuropeptide Y which resulted in a 30 x 2% increase in bile flow over the period 30-150 minutes after injection. (


METHODS
23 x 2 (1 x 2) ml/2 hours; neuropeptide Y 500 pM/kg: 30 x 5 (1 x 1) ml/2 hours). Biliary lipid composition was not altered significantly but bicarbonate output was increased at all doses tested. Intravenous infusion of neuropeptide Y (1000 pM) for 1 hour had no significant effect. Intracerebroventricular neuropeptide Y (1000 pM/250-300 mg body weight) also increased bile flow in urethane-anaesthetised rats. This effect was abolished by cervical vagotomy. The demonstration of a central stimulation of alkaline bile flow suggests that bile secretion may be subject to central modulation.
Farouk
M
M
Department of Surgery, Duke University Medical Center, Durham, NC 27710.
Geoghegan
J G
JG
Pruthi
R S
RS
Thomson
H J
HJ
Pappas
T N
TN
Meyers
W C
WC
D000818:Animals; D001639:Bicarbonates / Q000032:analysis; D001646:Bile / Q000737:chemistry / Q000378:metabolism*; D002552:Cerebral Ventricles; D002756:Cholagogues and Choleretics / Q000008:administration & dosage*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D007276:Injections, Intraventricular; D009478:Neuropeptide Y / Q000008:administration & dosage* / Q000494:pharmacology; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology*
D001639:Bicarbonates; D002756:Cholagogues and Choleretics; D009478:Neuropeptide Y