Viscosity of some contemporary contrast media before and after mixing with whole blood.
The viscosity of 7 contrast media was measured using a rotational viscometer. When solutions with similar iodine concentrations were compared, the highest viscosities were found for the nonionic dimers iodixanol and iotrolan, the lowest for diatrizoate, iopamidol, and iopromide, and intermediate values for iohexol and ioxaglate. The viscosity of iohexol and ioxaglate was found to vary linearly with temperature and quadratically with concentration. Whole-blood viscosity was measured for 5 subjects at high and low shear rates before and after mixing with contrast media in various proportions. Low-shear viscosity was found to decrease and high-shear viscosity to increase with contrast medium concentration. It is concluded that the contrast media currently used may affect blood rheology less than previous agents, despite their higher viscosity.
Smedby
O
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Department of Diagnostic Radiology, Uppsala University Hospital, Sweden.
D000328:Adult; D001809:Blood Viscosity / Q000187:drug effects*; D003287:Contrast Media / Q000737:chemistry* / Q000494:pharmacology; D003973:Diatrizoate / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007472:Iohexol / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D007479:Iopamidol / Q000737:chemistry / Q000494:pharmacology; D007485:Ioxaglic Acid / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D008962:Models, Theoretical; D014283:Triiodobenzoic Acids / Q000737:chemistry / Q000494:pharmacology; D014783:Viscosity
D003287:Contrast Media; D014283:Triiodobenzoic Acids; D003973:Diatrizoate; C033300:iotrolan; D007472:Iohexol; C038192:iopromide; C044834:iodixanol; D007479:Iopamidol; D007485:Ioxaglic Acid