Novel nucleoside strategies for anti-HIV and anti-HSV therapy.
This mini-review describes the structure-activity relationships of several series of new nucleoside analogues. It also points to the possibilities of finding new molecular modifications which could lead to antivirals with activity both against human immunodeficiency viruses (HIV) and herpesviruses.
Herdewijn
P A
PA
Laboratory of Pharmaceutical Chemistry, Rega Instituut, Leuven, Belgium.
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D015658:HIV Infections / Q000188:drug therapy* / Q000382:microbiology; D006561:Herpes Simplex / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use
D000998:Antiviral Agents; D009705:Nucleosides