title: [Sensitivity of multiresistant bacterial strains to imipenem (Tienam)].
abstract: The susceptibility to imipenem of 213 clinical strains of Gram-negative rods resistant to six cephalosporins (cephradine, cefamandole, cefuroxime, cefotaxime, cefoperazone and ceftriaxone) has been studied. It was found that 93.9% of the strains were sensitive and 6.1% were resistant to imipenem. In the examined group 64 (30%) out of 213 strains were simultaneously resistant to four aminoglycosides (gentamycin, tobramycin, netilmicin and amikacin); among them 5 (7.8%) strains were resistant to imipenem. Sensitivity to imipenem 157 out of 213 examined strains as compared to that of ceftazidime was as follows: 29.3% of the strains were sensitive and 3.8% resistant to both of the antibiotics, whilst 64.3% were imipenem-sensitive and ceftazidime-resistant. In vitro imipenem proved to be very active antibiotic against over 90% of multiresistant Gram-negative rods.
authors.affiliation: Katedry i Zakładu Mikrobiologii Lekarskiej AM, Wrocławiu.
authors.forename: J
authors.initials: J
authors.lastname: Ruczkowska
authors.forename: I
authors.initials: I
authors.lastname: Dolna
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002511:Cephalosporins / Q000494:pharmacology* / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D015378:Imipenem / Q000494:pharmacology* / Q000627:therapeutic use; D066298:In Vitro Techniques; D007231:Infant, Newborn; D008826:Microbial Sensitivity Tests / Q000379:methods
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D015378:Imipenem
vernacular_title: Wrazliwość wieloopornych szczepów bakteryjnych na imipenem (Tienam).