Effect of ketotifen on acute gastric lesions and gastric secretion in rats.
Ketotifen, a histamine H1-receptor antagonist and mast cell stabilizer, significantly protected the rat gastric mucosa against lesions induced by necrotizing agents, histamine or compound 48/80. The agent significantly inhibited the basal gastric acid secretion, but had little or no effect on the histamine-stimulated secretion. The mucosal protective effect was observed even at a dose that had little or no effect on gastric acid secretion, suggesting that ketotifen exhibits so-called cytoprotective activity.
Okabe
S
S
Department of Applied Pharmacology, Kyoto Pharmaceutical University, Japan.
Nakaji
S
S
Tachibana
M
M
D000818:Animals; D001241:Aspirin / Q000633:toxicity; D000431:Ethanol / Q000633:toxicity; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000293:injuries / Q000378:metabolism; D006632:Histamine / Q000633:toxicity; D007665:Ketotifen / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D003189:p-Methoxy-N-methylphenethylamine / Q000633:toxicity
D000431:Ethanol; D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine; D001241:Aspirin; D007665:Ketotifen