Time-dependent effects of oral morphine on autotomy following brachial nerve section in the rat.
In this study, the effects of morphine in drinking water on autotomy in male F344 rats having undergone brachial nerve sections were assessed during a 3-week period. Morphine was self-administered orally in tap water by the rats. Rats administered morphine just after the nerve section or 1 week after the nerve section showed a significant increase in the severity of autotomy when compared to the rats administered distilled water. Morphine had no effect on autotomy when it was administered 2 weeks after the nerve section. These results suggested that the effect of oral morphine on autotomy changes in a time-dependent manner.
Yamamoto
T
T
Department of Anesthesiology, School of Medicine, Chiba University, Japan.
Mizuguchi
T
T
D000284:Administration, Oral; D000818:Animals; D001917:Brachial Plexus / Q000502:physiology*; D003714:Denervation; D008297:Male; D009020:Morphine / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D011916:Rats, Inbred F344; D012652:Self Mutilation; D013997:Time Factors
D009020:Morphine