title: Three human osteosarcoma cell lines exhibiting different phenotypic expressions.
abstract: to elucidate the differences in histological features and biological behavior of osteosarcomas, three human osteoblastic-type osteosarcomas were studied in vitro and in nude mice. The secretory processing and extracellular fiber formation of type I collagen proved to be the most important factor in bone formation in the osteosarcomas. Alkaline phosphatase also seemed to be important. However, we were unable to find any particular protooncogene abnormalities which could have been implicated in the occurrence or biological behavior of these osteosarcomas.
authors.affiliation: First Department of Pathology, Niigata University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hotta
authors.forename: T
authors.initials: T
authors.lastname: Motoyama
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D002455:Cell Division; D003094:Collagen / Q000096:biosynthesis; D006801:Humans; D008854:Microscopy, Electron; D009368:Neoplasm Transplantation; D015675:Osteocalcin / Q000378:metabolism; D012516:Osteosarcoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D010641:Phenotype; D014407:Tumor Cells, Cultured
chemical_list: D015675:Osteocalcin; D003094:Collagen; D000469:Alkaline Phosphatase