Agrimoniin, an antitumor tannin of Agrimonia pilosa Ledeb., induces interleukin-1.
The induction of interleukin-1 (IL-1) by agrimoniin, a tannin of Agrimonia pilosa Ledeb., in human peripheral blood mononuclear cells (PBMC) in vitro and in mouse adherent peritoneal exudate cells (PEC) in vivo was studied. A significant amount of IL-1 beta in the culture supernatant of the human PBMC stimulated with agrimoniin was detected with an enzyme-linked immunoadherent assay. Agrimoniin induced IL-1 beta secretion dose- and time-dependently. The adherent PEC from mice intraperitoneally injected with agrimoniin (10 mg/kg) also secreted IL-1 4 days later. These results suggest that agrimoniin, a plant tannin, is a novel cytokine inducer.
Murayama
T
T
Department of Microbiology, Kanazawa Medical University, Ishikawa, Japan.
Kishi
N
N
Koshiura
R
R
Takagi
K
K
Furukawa
T
T
Miyamoto
K
K
D000328:Adult; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D047348:Hydrolyzable Tannins; D007375:Interleukin-1 / Q000096:biosynthesis*; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects / Q000276:immunology*; D010946:Plants, Medicinal; D013634:Tannins / Q000302:isolation & purification / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D047348:Hydrolyzable Tannins; D007375:Interleukin-1; D008070:Lipopolysaccharides; D013634:Tannins; C052420:agrimoniin