title: Desensitization of bradykinin-induced activation of peripheral nociceptors.
abstract: Bradykinin-induced activation of peripheral nociceptors has been studied in an isolated spinal cord/tail preparation from the neonatal rat. Prolonged administration of bradykinin consistently produced a selective desensitization which could be prevented by concanavalin A but not by succinyl concanavalin A or phenylarsine oxide. These data indicate that mannose-containing glycoproteins occur in or close to the bradykinin receptor site. In addition the desensitization observed under the present conditions, did not involve the internalization of bradykinin receptors.
authors.affiliation: Sandoz Institute for Medical Research, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Dray
authors.forename: I A
authors.initials: IA
authors.lastname: Patel
authors.forename: M N
authors.initials: MN
authors.lastname: Perkins
authors.forename: A
authors.initials: A
authors.lastname: Rueff
authors.forename: L
authors.initials: L
authors.lastname: Urban
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001152:Arsenicals / Q000494:pharmacology; D001920:Bradykinin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D003208:Concanavalin A / Q000494:pharmacology; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009412:Nerve Fibers / Q000187:drug effects / Q000502:physiology*; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology*
chemical_list: D001152:Arsenicals; C029341:oxophenylarsine; D003208:Concanavalin A; C019558:succinylconcanavalin A; D001920:Bradykinin