title: Evidence for gene-environmental interactions in Utah families with hypertension, dyslipidaemia and early coronary heart disease.
abstract: 1. Among 45,258 Utah families surveyed, about 4% have a strong aggregation of early coronary disease. In detailed clinical evaluation, about 21% of such high risk coronary families were found to have familial dyslipidaemic hypertension (FDH) and about 3% were found to have heterozygous familial hypercholesterolaemia (hFH). 2. Common and potentially modifiable environmental factors seem to play an important role in these high risk families. Non-genetic obesity promotes the expression of FDH. A high fat diet promotes the expression of FH. Cigarette smoking promotes earlier death in all coronary prone families. 3. Practical approaches are suggested for helping coronary prone pedigrees by applying our understanding of genetic and environmental factors that promote earlier coronary disease onset.
authors.affiliation: University of Utah Cardiovascular Genetics Research Clinic, Department of Internal Medicine, Salt Lake City.
authors.forename: R R
authors.initials: RR
authors.lastname: Williams
authors.forename: S C
authors.initials: SC
authors.lastname: Hunt
authors.forename: P N
authors.initials: PN
authors.lastname: Hopkins
authors.forename: L L
authors.initials: LL
authors.lastname: Wu
authors.forename: M C
authors.initials: MC
authors.lastname: Schumacher
authors.forename: B M
authors.initials: BM
authors.lastname: Stults
authors.forename: L
authors.initials: L
authors.lastname: Ball
authors.forename: J
authors.initials: J
authors.lastname: Ware
authors.forename: S J
authors.initials: SJ
authors.lastname: Hasstedt
authors.forename: J M
authors.initials: JM
authors.lastname: Lalouel
mesh_terms: D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000235:genetics*; D004200:Diseases in Twins; D004777:Environment; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000235:genetics*; D006938:Hyperlipoproteinemia Type II / Q000235:genetics; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014589:Utah