title: [Incidence, frequency and resistance characteristics of methicillin-oxacillin resistant Staphylococcus aureus strains in Germany].
abstract: In a multicentre study, the methicillin-resistant Staphylococcus aureus (MRSA) isolates in 19 large clinics in Germany were recorded, and the resistance characteristics of these strains were studied. Oxacillin-mannitol-salt agar plates were distributed to all participants to ensure uniformity of screening, and each laboratory used these plates to investigate 200 consecutive Staphylococcus aureus isolates for oxacillin-methicillin resistance. Of the 3,794 evaluable Staphylococcus aureus isolates, 71.5% were penicillin and 3.7% (142) oxacillin resistant; four study centres reported methicillin-oxacillin resistance rates of more than 5%. Of the MRSA isolates, 75% were also resistant to ciprofloxacin, 61% to fosfomycin, 52% to imipenem, 50% to trimethoprim/sulfamethoxazole and 36% to clindamycin. All isolates were sensitive to vancomycin and teicoplanin. Of the Staphylococcus aureus strains isolated from patients in intensive therapy units, 10.4% were methicillin-oxacillin resistant. Drains and catheter tips (9.8% and 5.2% respectively) were the materials with the highest proportions of MRSA. Of the MRSA isolates in this study, 58.2% belonged to lysis group II.
authors.affiliation: Abteilung für Infektionshygiene, Technischen Universität München.
authors.forename: A
authors.initials: A
authors.lastname: Voss
authors.forename: K
authors.initials: K
authors.lastname: Machka
authors.forename: W
authors.initials: W
authors.lastname: Lenz
authors.forename: D
authors.initials: D
authors.lastname: Milatovic
mesh_terms: D002939:Ciprofloxacin / Q000494:pharmacology; D002981:Clindamycin / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D005578:Fosfomycin / Q000494:pharmacology; D005858:Germany; D006801:Humans; D015378:Imipenem / Q000494:pharmacology; D008712:Methicillin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010068:Oxacillin / Q000494:pharmacology*; D010403:Penicillin Resistance; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D017334:Teicoplanin / Q000494:pharmacology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology; D014640:Vancomycin / Q000494:pharmacology
chemical_list: D005578:Fosfomycin; D002981:Clindamycin; D002939:Ciprofloxacin; D017334:Teicoplanin; D014640:Vancomycin; D015378:Imipenem; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D008712:Methicillin; D010068:Oxacillin
vernacular_title: Vorkommen, Häufigkeit und Resistenzverhalten von Methicillin-Oxacillin-resistenten Staphylococcus-aureus-Stämmen in Deutschland.