[The role of disorders in the structural-functional properties of the erythrocyte membranes and energy metabolism in the progression of anemia in patients with terminal kidney failure].
As many as 30 healthy persons and 65 patients suffering from chronic glomerulonephritis with terminal renal failure (TRF) placed on program dialysis were examined for lipid composition of the membranes and functional properties of red blood cells. By the gravity of anemia the patients were distributed into 2 groups. It has been established that in the red blood cell membranes, there was an increase of the content of cholesterol and sphingomyelin, and a decline of the content of phosphatidylcholine, phosphatidylethanolamine and phosphatidylserine. In addition to the changes in the lipid content of red blood cells, the peripheral red blood cell pool showed an increase of the amount of pathologically shaped cells, a reduction of the cell capacity to deformation, a rise of the content of fibrinogen in the supramembranous layer. Destruction of the phospholipid matrix of the red blood cell membrane was attended by noticeable restructure of the work of the multienzymic complex of glycolysis, resulting in energy metabolism destabilization. Analysis of the data obtained has demonstrated that as the structural and functional properties of the membranes underwent alterations and the mechanisms of stabilization of red blood cell energy homeostasis got disintegrated, anemia in patients with TRF became graver.
Iudanova
L S
LS
Iakovleva
E V
EV
Zakharova
N B
NB
Cherneva
I I
II
D000293:Adolescent; D000328:Adult; D000740:Anemia / Q000097:blood* / Q000209:etiology; D004734:Energy Metabolism; D004910:Erythrocyte Membrane / Q000737:chemistry / Q000378:metabolism / Q000648:ultrastructure*; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications; D008297:Male; D008563:Membrane Lipids / Q000097:blood; D010743:Phospholipids / Q000097:blood
D006454:Hemoglobins; D008563:Membrane Lipids; D010743:Phospholipids
Rol' narusheniĭ strukturno-funktsional'nykh svoĭstv membran i énergoobmena éritrotsitov v progressirovanii anemii u bol'nykh s terminal'noĭ pochechnoĭ nedostatochnost'iu.