title: [Moderate Paget's disease treated with pamidronate (APD): experience in 43 patients with a single 60 mg infusion of varying duration of 1-to-24 hours].
abstract: Pamidronate disodium (APD) given as a single 60 mg intravenous infusion over 24 hours was shown to be an effective treatment for Paget's disease of bone. To further improve the feasibility of a simple treatment that ensures compliance in elderly outpatients (pts), we investigated the effectiveness of a single 60 mg APD intravenous infusion given over 8 hours (12 pts), 4 hours (9 pts) and 1 hour (10 pts) compared with that over 24 hours (12 pts). Infusion rate of APD was 7.5, 15 and 60 mg/h respectively, in comparison with 2.5 mg/h previously. Clinical improvement and biochemical remission were observed in all patients. Side effects, limited to mild transient fever and local transient increase in bone pain, occurred in 9 patients (2-3 pts in each group). There was no difference in the fall of plasma alkaline phosphatase and of urinary hydroxyproline between the 4 infusion rates. Plasma alkaline phosphatase (U/l, mean +/- SEM) decreased from 263 +/- 34 to 110 +/- 8 (1 h infusion), from 251 +/- 26 to 102 +/- 9 (4 h), from 237 +/- 23 to 95 +/- 9 (8 h) and from 256 +/- 29 to 97 +/- 7 (24 h), from day 0 to day 180 respectively (all p < 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Département de médecine interne, Centre hospitalier universitaire vaudois, Lausanne.
authors.forename: D
authors.initials: D
authors.lastname: Thiébaud
authors.forename: L
authors.initials: L
authors.lastname: Portmann
authors.forename: P
authors.initials: P
authors.lastname: Burckhardt
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood; D000553:Ambulatory Care; D003404:Creatinine / Q000652:urine; D004164:Diphosphonates / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000652:urine; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000188:drug therapy*; D000077268:Pamidronate; D013997:Time Factors
chemical_list: D004164:Diphosphonates; D003404:Creatinine; D000469:Alkaline Phosphatase; D000077268:Pamidronate; D006909:Hydroxyproline
vernacular_title: Maladie de Paget modérée, traitée par le pamidronate (APD): expérience chez 43 patients avec une perfusion unique de 60 mg d'une durée variable de 1 à 24 heures.