The potential of molecular biology for the production of monoclonal antibodies derived from outbred veterinary animals.
The protein structure of immunoglobulins and the genetics on the regulation of immunoglobulin expression are reviewed. This basic knowledge has led to the development of systems to produce monoclonal antibodies in eukaryotic or prokaryotic cells. The potential and limitations of molecular biology for the understanding of immunoglobulin regulation and for the production of monoclonal antibodies derived from animals of veterinary importance are discussed.
Suter
M
M
Schweizerisches Institut für Allergie- und Asthmaforschung (SIAF), Davos-Platz, Switzerland.
D000595:Amino Acid Sequence; D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology; D000916:Antibody Diversity / Q000235:genetics; D001483:Base Sequence; D002417:Cattle; D005803:Genes, Immunoglobulin; D007136:Immunoglobulins / Q000737:chemistry / Q000235:genetics; D008967:Molecular Biology; D008969:Molecular Sequence Data; D011817:Rabbits; D011994:Recombinant Proteins / Q000096:biosynthesis
D000911:Antibodies, Monoclonal; D007136:Immunoglobulins; D011994:Recombinant Proteins