title: Efficacy of massive oral doses of retinyl palmitate and mango (Mangifera indica L.) consumption to correct an existing vitamin A deficiency in Senegalese children.
abstract: Administration of large oral doses of retinyl palmitate has become the most widely practised vitamin A deficiency prevention strategy in developing countries. We conducted a follow-up study among 220 Senegalese children aged 2-7 years suffering from moderate undernutrition to determine the efficacy of vitamin A treatment on their vitamin A status assessed by biochemical and cytological (impression cytology with transfer) methods. The first examination (T = 0 m[onth]) was carried out during April 1989, before the mango (Mangifera indica L,) harvest. The second examination (T = 2 m) was carried out 2 months after vitamin A treatment during June 1989 when ripe mangoes become widely available. Conjunctival cells of the eyes of the children with or without ocular inflammation were responsive to vitamin A administration (P < 0.01). There was a significant increase (P < 0.001) in mean serum retinol and beta-carotene levels between T = 0 m and T = 2 m. Mean serum retinol-binding protein (RBP) and transthyretin (TTR) levels did not differ significantly (P > 0.05) at T = 0 m and T = 2 m. Despite the intake of vitamin A, 54% of the children who had abnormal cytology at T = 0 m remained abnormal at T = 2 m. This was due to inadequate levels of TTR and RBP, presumably due to the cereal diet eaten by the Senegalese population. children with abnormal eye cytology had lower serum retinol levels than those with normal eyes at T = 0 m, and beta-carotene values did not correlate with eye cytological abnormalities at T = 0 m. Children with normal cytology had higher serum retinol and also beta-carotene levels than those with abnormal cytology after massive oral doses of vitamin A and consumption of mangoes at T = 2 m. Retinyl palmitate may, therefore, only lead to partial cytological improvement due to a lack of retinol-carrier proteins but dietary beta-carotene may also be involved.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), Unité 56, Hôpital de Bicêtre, France.
authors.forename: C
authors.initials: C
authors.lastname: Carlier
authors.forename: M
authors.initials: M
authors.lastname: Etchepare
authors.forename: J F
authors.initials: JF
authors.lastname: Ceccon
authors.forename: M S
authors.initials: MS
authors.lastname: Mourey
authors.forename: O
authors.initials: O
authors.lastname: Amédée-Manesme
mesh_terms: D002338:Carotenoids / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003228:Conjunctiva / Q000166:cytology / Q000378:metabolism*; D004224:Diterpenes; D004334:Drug Administration Schedule; D005128:Eye Diseases / Q000097:blood / Q000378:metabolism; D005500:Follow-Up Studies; D005638:Fruit; D006801:Humans; D000084562:Retinyl Esters; D012675:Senegal; D014801:Vitamin A / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood; D014802:Vitamin A Deficiency / Q000188:drug therapy*; D019207:beta Carotene
chemical_list: D004224:Diterpenes; D000084562:Retinyl Esters; D019207:beta Carotene; D014801:Vitamin A; C014794:retinol palmitate; D002338:Carotenoids