title: [Modeling in biology. Structured analysis of intracellular calcium oscillations in electrically non-excitable cells].
abstract: In this paper a systematic approach to the mathematical modeling of intracellular Ca2+ oscillations is introduced. After a structured analysis a stochastic model of the system is derived which is numerically tractable by means of a stochastic simulation. A critical discussion of theoretical models for Ca2+ oscillations reveals that not all of the proposed mechanisms are consistent with experimental data. In addition, a model for oscillatory calcium waves is presented. Uncovering these mechanisms facilitates the design of anti-mitotic drugs interfering with Ca2+ metabolism.
authors.affiliation: AG Medizinische Physik und Elektronenmikroskopie, Institut für Immunobiologie der Universität, Freiburg, FRG.
authors.forename: M
authors.initials: M
authors.lastname: Kraus
authors.forename: B
authors.initials: B
authors.lastname: Wolf
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002468:Cell Physiological Phenomena; D004594:Electrophysiology; D007424:Intracellular Fluid / Q000378:metabolism; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological; D009991:Oscillometry; D015290:Second Messenger Systems
chemical_list: D002118:Calcium
vernacular_title: Modellbildung in der Biologie. Strukturierte Analyse intrazellulärer Calcium-Oszillationen in elektrisch nicht erregbaren Zellen.