title: Terodiline in the treatment of nocturnal enuresis in children.
abstract: The effect of terodiline was investigated in 17 children with nocturnal enuresis. Twelve of them were evaluated urodynamically before treatment and 6 of these were proved to have detrusor instability with or without provocation. Terodiline in a daily dose of 12.5 mg was administered for 4 weeks. After treatment the number of wet nights per week has significantly decreased. Urodynamically, maximum cystometric capacity has statistically increased and in 2 patients involuntary contraction has disappeared. During these periods no serious side effects were encountered. Terodiline could improve urodynamic parameters in nocturnal enuresis. These changes appear to be favourable in clinical improvement.
authors.affiliation: Department of Urology, Yamagata University, School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ishigooka
authors.forename: T
authors.initials: T
authors.lastname: Hashimoto
authors.forename: I
authors.initials: I
authors.lastname: Sasagawa
authors.forename: K
authors.initials: K
authors.lastname: Izumiya
authors.forename: T
authors.initials: T
authors.lastname: Nakada
mesh_terms: D002082:Butylamines / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D004775:Enuresis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D010276:Parasympatholytics / Q000008:administration & dosage / Q000627:therapeutic use*; D014563:Urodynamics / Q000187:drug effects
chemical_list: D002082:Butylamines; D010276:Parasympatholytics; C010637:terodiline