Effects of surgical trauma on interleukin 2 production and interleukin 2 receptor expression.
To elucidate the mechanism of immunologic abnormalities induced by surgical trauma, we measured interleukin 2 (IL-2) production and IL-2 receptor expression in peripheral blood mononuclear cells from 16 patients with cholelithiasis. Compared with preoperative levels, IL-2 production and IL-2 receptor expression were significantly reduced on postoperative day 4, and the reduction was consistent with the suppression of lymphocyte proliferative response to phytohemagglutinin.
Li
H
H
Department of Surgery, Xiehe Hospital, Tongji Medical University, Wuhan.
Xiong
S T
ST
Zhang
S X
SX
Liu
S B
SB
Luo
Y
Y
D000328:Adult; D000368:Aged; D002769:Cholelithiasis / Q000378:metabolism* / Q000601:surgery; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D007376:Interleukin-2 / Q000096:biosynthesis*; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D015375:Receptors, Interleukin-2 / Q000378:metabolism*
D007376:Interleukin-2; D015375:Receptors, Interleukin-2