title: Irradiated trauma victims: the impact of ionizing radiation on surgical considerations following a nuclear mishap.
abstract: The combination of conventional traumatic injuries and radiation exposure has synergistic consequences, the full extent of which may take days to weeks to become apparent. Our understanding of such is derived from a variety of laboratory and clinical scenarios involving both therapeutic and accidental exposures. When presented with such an individual one must discern whether the victim has been bodily contaminated versus exposed to a source or both. The former will necessitate decontamination procedures which may be as simple as declothing and showering the individual. Simply removing the victim from the source will suffice to halt further radiation induced injury. In the vast majority of cases basic life support and other emergency medical procedures should be expeditiously instituted as warranted and without fear of personal hazard for health care teams. Following stabilization, further medical/surgical support must be predicated upon the extent of the radiation injury with the circulating absolute lymphocyte count serving as both a reliable and readily accessible indicator of the degree of underlying radiation injury. As radiation has profound consequences on immune and wound healing systems, therapies must be tempered by an understanding of the impact of radiation upon these systems. Overall, the consequences of irradiation injury will be the potential for an exacerbation of the effects of conventional traumatic injuries with a higher than expected morbidity and mortality.
authors.affiliation: Department of Surgery, Boston University School of Medicine, Massachusetts.
authors.forename: E F
authors.initials: EF
authors.lastname: Hirsch
authors.forename: G J
authors.initials: GJ
authors.lastname: Bowers
mesh_terms: D000059:Accidents; D000208:Acute Disease; D004190:Disasters; D004630:Emergencies; D006801:Humans; D009688:Nuclear Reactors; D011832:Radiation Injuries / Q000150:complications / Q000209:etiology / Q000601:surgery*; D011839:Radiation, Ionizing