[Turner syndrome: a virtually certain indication for growth hormone treatment].
Short stature is a feature in almost all cases with Turner syndrome. The etiology is unknown, but GH secretion appears to be normal. The treatment with anabolic steroids does not seem to increase final height. Oestrogens are needed for secondary sex characteristics, but should be given in a low dosage and at approximately 12-13 years of age, in order not to compromise final height. Growth hormone increases growth velocity and leads to an average gain of 5 cm in terms of final height. The addition of oxandrolone leads to an even higher growth rate, but final height is probably similar to that reached by growth hormone alone. The dosage, injection frequency, age and bone age at the start of therapy have influence on the efficacy. GH in the dosages given appears safe.
Rongen-Westerlaken
C
C
Afd. Kindergeneeskunde, Academisch Ziekenhuis Nijmegen, St. Radboud Ziekenhuis.
Wit
J M
JM
D000365:Age Determination by Skeleton; D001827:Body Height / Q000187:drug effects; D002648:Child; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004967:Estrogens / Q000627:therapeutic use; D005260:Female; D006128:Growth / Q000187:drug effects; D013006:Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D010074:Oxandrolone / Q000008:administration & dosage; D014424:Turner Syndrome / Q000188:drug therapy*
D004967:Estrogens; D010074:Oxandrolone; D013006:Growth Hormone
Turner-syndroom: een vrijwel vaststaande indicatie voor groeihormoonbehandeling.