Evolution of pericentromeric heterochromatin of human X chromosome.
An unusual large heterochromatic segment around the pericentromeric region of the X-chromosome is reported. In normal circumstances, the pericentromeric region of the X-chromosome is negative by the restriction endonuclease AluI/Giemsa technique. However, this unusual X-chromosome was found to have AluI resistant (positive) chromatin. The evolution of extra heterochromatin is a postzygotic event as substantiated by the presence of a normal cell line.
Luke
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Division of Genetics, Long Island College Hospital, SUNY Health Science Center, Brooklyn 11201.
Mathews
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T
Verma
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D005075:Biological Evolution; D002503:Centromere; D002648:Child; D006570:Heterochromatin; D006801:Humans; D007621:Karyotyping; D008297:Male; D014960:X Chromosome
D006570:Heterochromatin