Influence of recombinant interleukin-2 and tumor necrosis factor-alpha on the development of ethyl nitrosourea-induced brain tumors.
Using the experimental model of brain tumors induced by ethyl-nitrosourea (ENU), human recombinant interleukin-2 (rIL-2) and tumor necrosis factor-alpha (TNF-alpha) were administered to Wistar rats in early stages of carcinogenesis. The results obtained suggest that IL-2 does not influence the development of nervous system tumors. In contrast, TNF-alpha was capable of modulating the development of ENU-induced tumors, producing a reduction in the number of schwannomas and a delay in the appearance of intraparenchymatous brain tumors.
Vaquero
J
J
Neurosurgical Department, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain.
Arias
A
A
Zurita
M
M
Coca
S
S
Oya
S
S
Morales
C
C
D000818:Animals; D001932:Brain Neoplasms / Q000139:chemically induced* / Q000401:mortality / Q000517:prevention & control; D005038:Ethylnitrosourea; D005260:Female; D007376:Interleukin-2 / Q000494:pharmacology*; D009442:Neurilemmoma / Q000139:chemically induced* / Q000401:mortality / Q000517:prevention & control; D009837:Oligodendroglioma / Q000139:chemically induced* / Q000401:mortality / Q000517:prevention & control; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
D007376:Interleukin-2; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D005038:Ethylnitrosourea