[Isolation and evaluation of the structure of the new anthracycline antibiotics rubomycins F and H].
The rubomycin complex produced by Streptomyces coeruleorubidus 4-157 was studied and the two novel anthracyclines i.e. rubomycins F and H were isolated. The study of the physicochemical properties of the novel antibiotics in comparison with rubomycin C (daunomycin) and the specially prepared 3'-N-carbmethoxyrubomycin C showed that rubomycin F was 3'-N-carbethoxydaunomycin and rubomycin H was 3'-N-carbmethoxydaunomycin. Therefore, rubomycins F and H are novel representatives of natural anthracyclines undescribed previously.
Fomicheva
E V
EV
Fedorova
G B
GB
Potapova
N P
NP
Katrukha
G S
GS
D001407:Bacillus / Q000187:drug effects; D002725:Chloroform / Q000494:pharmacology; D002855:Chromatography, Thin Layer / Q000379:methods; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004926:Escherichia coli / Q000187:drug effects; D066298:In Vitro Techniques; D016982:Micrococcus luteus / Q000187:drug effects; D008954:Models, Biological; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013211:Staphylococcus aureus / Q000187:drug effects; D013302:Streptomyces / Q000378:metabolism*
C076482:rubomycin F; C076483:rubomycin H; D002725:Chloroform; D003630:Daunorubicin
Vydelenie i ustanovlenie stroeniia novykh antratsiklinovykh antibiotikov rubomitsinov F i H.