[Uses in fibronectin on eschar-excised wound to promote expansion of skin grafts].
Fibronectin was applied to wounds resulted from excision of burn eschars at different time intervals after burn in piglets, for the purpose of studying the effect of Fn in promoting the expansion of skin grafts which were laid on the wounds. Fn content in wound tissue was measured by means of ELISA, while tissue Fn and Type-III collagen localization was identified by immunohistochemical method ABC. The rate of the graft expansion was then measured by Automated Scanning Image Analyzer. The results showed that topical application of exogenous Fn on the wound could rapidly increase the density gradient of tissue Fn on the wound and promote expansion of skin grafts.
Xiao
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NK
Xijing Hospital, Fourth Military Medical University of PLA, Xian.
D000287:Administration, Topical; D000818:Animals; D002056:Burns / Q000188:drug therapy / Q000601:surgery*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005353:Fibronectins / Q000378:metabolism / Q000627:therapeutic use*; D007091:Image Processing, Computer-Assisted; D008297:Male; D016038:Skin Transplantation; D013552:Swine; D015626:Tissue Expansion
D005353:Fibronectins