[A stereoscopic analysis of centrosome structure in the cells of a tissue culture under the action of energy metabolism inhibitors. I. 2,4-Dinitrophenol, deoxyglucose, sodium azide and the calcium ionophore A23187].
A 30-min action of energy transfer inhibitors (2,4-dinitrophenol, deoxyglucose, azide and calcium ionophore A23187) on tissue culture cells results in a significant increase in the quantity of microtubules around the centrosome. After the action of all the inhibitors, mostly increases the number of long microtubules with free proximal end oriented towards the centrosome. It is suggested that energy transfer inhibitors may stimulate foundation of microtubules on the centrosome and stabilize free microtubules, while they exert no effect on the frequency of detachment of microtubules from the centrosome.
Alieva
I B
IB
Vorob'ev
I A
IA
D019297:2,4-Dinitrophenol; D000818:Animals; D001386:Azides / Q000494:pharmacology*; D000001:Calcimycin / Q000494:pharmacology*; D046508:Culture Techniques; D003593:Cytoplasm / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D003847:Deoxyglucose / Q000494:pharmacology*; D003864:Depression, Chemical; D004140:Dinitrophenols / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects*; D008870:Microtubules / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D019810:Sodium Azide; D013552:Swine; D014475:Uncoupling Agents / Q000494:pharmacology*
D001386:Azides; D004140:Dinitrophenols; D014475:Uncoupling Agents; D000001:Calcimycin; D019810:Sodium Azide; D003847:Deoxyglucose; D019297:2,4-Dinitrophenol
Stereoskopicheskiĭ analiz stroeniia tsentrosomy v kletkakh kul'tury tkani pri deĭstvii ingibitorov énergeticheskogo obmena. I. 2,4-Dinitrofenol, dezoksigliukoza, azid natriia i kal'tsievyĭ ionofor A23187.