title: [The effectiveness of ultralow doses and concentrations of biologically active compounds].
abstract: Numerous data of literature are analysed on the biological activity of ultra-low (10(-12)-10(-19) M) concentrations and corresponding doses of same bioregulators. Our own data are presented on the modulation of lymphatic vessel contractility by peptides (thyroliberin, defensin, and tuftsin) in concentrations ranging from 10(-13) to 10(-16) M. Hypothetic mechanisms of these phenomena are discussed.
authors.forename: I P
authors.initials: IP
authors.lastname: Ashmarin
authors.forename: T V
authors.initials: TV
authors.lastname: Lelekova
authors.forename: L Ts
authors.initials: LTs
authors.lastname: Sanzhieva
mesh_terms: D000818:Animals; D001685:Biological Factors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008208:Lymphatic System / Q000187:drug effects / Q000502:physiology; D009119:Muscle Contraction / Q000187:drug effects; D010455:Peptides / Q000494:pharmacology
chemical_list: D001685:Biological Factors; D010455:Peptides
vernacular_title: Ob éffektivnosti ul'tramalykh doz i kontsentratsiĭ biologicheski aktivnykh soedineniĭ.