title: Serotonin modulates auditory information processing in the cochlear nucleus of the rat.
abstract: The effect of iontophoretic application of serotonin (5-HT) was studied in neurons of the cochlear nucleus in the rat. 5-HT inhibited the spontaneous activity in 71%, and the tone-evoked activity in 32% of the neurons. We also observed an excitatory effect, with a longer latency than that of the inhibition, in 40% of the neurons. In some neurons 5-HT had both inhibitory and excitatory effects. Neurons with different response types seem to have different sensitivities to 5-HT. As the effects of 5-HT were generally weaker than those of other putative neurotransmitters, it probably has only a small modulatory influence on auditory processing.
authors.affiliation: Universität Tübingen, Tierphysiologie, FRG.
authors.forename: U
authors.initials: U
authors.lastname: Ebert
authors.forename: J
authors.initials: J
authors.lastname: Ostwald
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001306:Auditory Pathways / Q000166:cytology / Q000502:physiology*; D003051:Cochlea / Q000166:cytology / Q000502:physiology*; D004566:Electrodes; D005260:Female; D007478:Iontophoresis; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000502:physiology*
chemical_list: D012701:Serotonin