[Results of the treatment of steroid-resistant and steroid-dependent nephrotic syndrome with pulsed doses of prednisolone].
In 12 children with steroid-resistant and 17 with steroid-sensitive nephrotic syndrome massive doses of prednisolone were used in intravenous infusions ("pulses"). In 8 children with steroid-resistant and 9 with steroid-sensitive nephrotic syndrome very good or good results were obtained. The authors suppose that in a part of the children previous ineffectiveness of this immunosuppressive treatment could have been due to insufficient dosage. Rosette tests before and after pulses demonstrated a reduction of the total number of T-cells after pulses. The change of the ratio of theophylline-resistant to theophylline-sensitive lymphocytes suggests that this reduction was caused mainly by a fall of the number of helper T-cells and non-specific cytotoxic cells.
Gura
C
C
Katedry i Kliniki Pediatrii i Nefrologii Ak. Med., Warszawie.
Pałka
L
L
Pańczyk-Tomaszewska
M
M
Sieniawska
M
M
Pazdur
J
J
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009404:Nephrotic Syndrome / Q000188:drug therapy*; D011239:Prednisolone / Q000008:administration & dosage*; D012008:Recurrence; D012074:Remission Induction; D013997:Time Factors
D011239:Prednisolone
Wyniki leczenia "uderzeniowymi" dawkami prednisolonu sterydoopornych i sterydozaleznych zespołów nerczycowych.