The role of recombinant human tissue-type plasminogen activator in the treatment of acute pulmonary thromboembolism.
The effect of intravenous recombinant human tissue-type plasminogen activator (tPA) on arterial blood gases was compared with the effect of heparin treatment in acute pulmonary thromboembolism. Fifteen patients received heparin alone (group A), 5 cases were treated with 7.7 x 10(6) I.U. of tPA (group B) and 10 cases with 15 x 10(6) I.U. of tPA (group C) combined with heparin treatment. Arterial oxygen tension before treatment was not significantly different among the three groups. PaO2 was dramatically improved on the 1st day in group C. By the 7th day, PaO2 of group B had improved to the level of group C. However, the PaO2 of group A on the 7th day was not significantly different compared to the pre-treatment value. In group C, post-treatment perfusion lung scintigrams were improved compared to the pre-treatment images, but this was not the case in group B. Treatment with tPA is more effective for acute pulmonary thromboembolism than heparin alone and a high dose of tPA (15 x 10(6) I.U.) leads to rapid improvement in arterial blood gases and lung perfusion images.
Yamasawa
F
F
Department of Medicine, School of Medicine, Keio University, Tokyo, Japan.
Okada
Y
Y
Asano
K
K
Mori
M
M
Fujita
H
H
Hasegawa
N
N
Aoki
T
T
Ishizaka
A
A
Kanazawa
M
M
Kawashiro
T
T
D000208:Acute Disease; D004359:Drug Therapy, Combination; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011655:Pulmonary Embolism / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011877:Radionuclide Imaging; D011993:Recombinant Fusion Proteins / Q000627:therapeutic use; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
D005338:Fibrin Fibrinogen Degradation Products; D011993:Recombinant Fusion Proteins; D005340:Fibrinogen; D006493:Heparin; D010959:Tissue Plasminogen Activator; D010100:Oxygen