Plasma exudation by activated plasma kallikrein after intraperitoneal injection of lambda-carrageenin or endotoxin in rats.
The experimental study was carried out to examine whether intraperitoneal injection of carrageenin or endotoxin activates plasma kallikrein-kinin system to induce plasma exudation in rats. Intraperitoneal injection of 2% lambda-carrageenin induced plasma exudation in the peritoneal cavity by activation of plasma prekallikrein. Intraperitoneal injection of endotoxin (3mg/kg) also resulted in intraperitoneal plasma exudation, but plasma kallikrein-kinin system did not seem to be involved.
Sugimoto
K
K
Department Traumatology & Critical Care Medicine, Kitasato University, School of Medicine, Kanagawa, Japan.
Shindo
M
M
Owada
T
T
Majima
M
M
Katori
M
M
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001920:Bradykinin / Q000031:analogs & derivatives / Q000097:blood*; D002351:Carrageenan / Q000494:pharmacology*; D004731:Endotoxins / Q000494:pharmacology*; D004789:Enzyme Activation; D004926:Escherichia coli; D007249:Inflammation; D007610:Kallikreins / Q000378:metabolism*; D008297:Male; D010538:Peritonitis / Q000097:blood* / Q000139:chemically induced / Q000201:enzymology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D012772:Shock, Septic / Q000097:blood* / Q000503:physiopathology
D004731:Endotoxins; D002351:Carrageenan; D007610:Kallikreins; D001920:Bradykinin