Experimental studies on the inhibition effects of 1000 Chinese medicinal herbs on the surface antigen of hepatitis B virus.
The reverse passive hemagglutination inhibition test was used in the screening of 1000 Chinese materia medica for inhibitors of hepatitis B virus surface antigen. The herbal drugs were commercially available and the surface antigen was from sera of hepatitis B patients. 127 effective drugs were obtained from the survey of which 28 were highly inhibitory (8:1), 35 were moderately effective (4:1), and 64 mildly effective (2:1). Further experiments with varying dosages of the drug, dosages of HBsAg and duration of contact showed 10 drugs to be of optimal effect.
Zheng
M
M
Department of Microbiology, Jiangxi Medical College, Nanchang.
Zheng
Y
Y
D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002353:Carrier State / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D006385:Hemagglutination Inhibition Tests; D006509:Hepatitis B / Q000188:drug therapy; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006515:Hepatitis B virus / Q000187:drug effects*; D006801:Humans
D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D006514:Hepatitis B Surface Antigens