title: Role of adrenal androgens in the development of arteriosclerosis as judged by pulse wave velocity and calcification of the aorta.
abstract: To evaluate the role of adrenal androgens in the development of arteriosclerosis, serum dehydroepiandrosterone sulfate (DHEAS), dehydroepiandrosterone (DHEA), aortic calcification and pulse wave velocity (PWV) were measured in 69 males and 119 females without overt cardiovascular disease. The steroids decreased with age in both sexes, and the reduction was significantly steeper in younger (< or = 40 years) than in older (> 40 years) subjects only in females. When adjusted for age, the steroids were significantly lower in subjects with aortic calcification than in those without it, and the PWV was significantly slower in the latter. Adrenal androgens appear to retard the development and/or progression of arteriosclerosis.
authors.affiliation: Department of Geriatrics, Endocrinology and Metabolism, School of Medicine, Shinshu University, Matsumoto, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Ishihara
authors.forename: K
authors.initials: K
authors.lastname: Hiramatsu
authors.forename: S
authors.initials: S
authors.lastname: Shigematsu
authors.forename: T
authors.initials: T
authors.lastname: Aizawa
authors.forename: A
authors.initials: A
authors.lastname: Niwa
authors.forename: N
authors.initials: N
authors.lastname: Takasu
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: K
authors.initials: K
authors.lastname: Matsuo
mesh_terms: D000293:Adolescent; D000311:Adrenal Glands / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000728:Androgens / Q000502:physiology*; D001013:Aorta, Thoracic / Q000503:physiopathology; D001161:Arteriosclerosis / Q000503:physiopathology*; D001783:Blood Flow Velocity / Q000502:physiology; D002114:Calcinosis / Q000503:physiopathology; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives / Q000502:physiology; D019314:Dehydroepiandrosterone Sulfate; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000728:Androgens; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate