Dual role of S-nitrosocaptopril as an inhibitor of angiotensin-converting enzyme and a nitroso group carrier.
The S-nitroso derivatives of captopril can act as an inhibitor of an angiotensin-converting enzyme in the presence of thiol such as glutathione. S-Nitrosocaptopril also rapidly transfers its nitroso moiety to a heme protein, which is presumably the responsible mechanism for the activation of guanylate cyclase. These results suggest that S-nitrosocaptopril may serve as an effective hypotensive agent.
Park
J W
JW
Department of Biochemistry, College of Natural Sciences, Kyungpook National University, Taegu, Korea.
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D002216:Captopril / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D005978:Glutathione; D006454:Hemoglobins / Q000378:metabolism; D007700:Kinetics; D013053:Spectrophotometry
D000806:Angiotensin-Converting Enzyme Inhibitors; D006454:Hemoglobins; C060039:S-nitrosocaptopril; D002216:Captopril; D005978:Glutathione