title: [Transfusion-associated graft-vs-host disease in a patient with Hodgkin's disease].
abstract: Transfusion-associated graft-versus-host disease (TA-GVHD) is a serious complication of blood transfusion which is caused by immunocompetent donor lymphocytes reacting against recipient antigens. We report a case of TA-GVHD in a male patient with Hodgkin's disease who had received several units of non-irradiated blood components. TA-GVHD was diagnosed by histological examination of affected skin and demonstration of engrafted lymphocytes of female phenotype by in situ hybridization using a Y-chromosome specific probe. The need to irradiate blood components given to patients in defined risk-groups is stressed.
authors.affiliation: Klinisk immunologisk afdeling, Odense Sygehus.
authors.forename: S T
authors.initials: ST
authors.lastname: Lillevang
authors.forename: C B
authors.initials: CB
authors.lastname: Andersen
authors.forename: K G
authors.initials: KG
authors.lastname: Schmidt
authors.forename: K
authors.initials: K
authors.lastname: Riisom
mesh_terms: D000328:Adult; D017707:Erythrocyte Transfusion; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D006689:Hodgkin Disease / Q000276:immunology / Q000628:therapy*; D006801:Humans; D008297:Male; D017713:Platelet Transfusion; D065227:Transfusion Reaction
vernacular_title: Transfusionsassocieret graft-versus-host disease hos en patient med Hodgkin's sygdom.