Ventilatory failure induced by tracheal banding in the hamster.
Previous animal models of hypercapnic ventilatory failure are limited in that the resistive load has only been applied acutely and often in anesthetized animals. We therefore developed a chronic animal model of hypercapnic ventilatory failure by increasing airway resistance via tracheal banding over several days. To test the efficacy of this model, we compared arterial blood gases, pulmonary function, and internal area of the trachea 6 days after the banding or sham procedure in 20 hamsters. Six days later, banded animals had an increased airway resistance as indicated by a 66% reduction in internal cross-sectional area of the trachea and a 6.5-fold increase in pulmonary resistance compared with control hamsters. The increased airway resistance resulted in a severe respiratory acidosis and hypoxemia in the awake banded hamsters. Banded hamsters were also hyperinflated. This animal model will be useful for investigating the various mechanisms that contribute to hypercapnic ventilatory failure and interventions that may promote recovery.
Reid
W D
WD
University of British Columbia Pulmonary Research Laboratory, St. Paul's Hospital, Vancouver, Canada.
Noonan
J
J
Chung
F
F
Tesler-Mabe
C
C
D000142:Acidosis, Respiratory / Q000378:metabolism; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001784:Blood Gas Analysis; D001835:Body Weight / Q000502:physiology; D006224:Cricetinae; D004195:Disease Models, Animal; D004947:Esophagus / Q000502:physiology; D000860:Hypoxia / Q000378:metabolism; D008176:Lung Volume Measurements; D008647:Mesocricetus; D012131:Respiratory Insufficiency / Q000473:pathology / Q000503:physiopathology*; D015656:Respiratory Mechanics / Q000502:physiology; D014132:Trachea / Q000473:pathology / Q000503:physiopathology*
D001285:Atropine