Molecular evolution of cyclooxygenase and lipoxygenase.
Four oxygenases of the arachidonic acid cascade (cyclooxygenase, 5-lipoxygenase, 12-lipoxygenase and 15-lipoxygenase) were investigated by the method of computer-assisted sequence comparison. From the calculations, some aspects of evolution and function of these enzymes were revealed. (1) The evolutionary origin of cyclooxygenase was different from that of lipoxygenases. (2) Cyclooxygenase was a distantly related member of a peroxidase family. (3) Enzymes with 12-lipoxygenase activity were created independently twice by gene duplication.
Toh
H
H
Protein Engineering Research Institute, Osaka, Japan.
Yokoyama
C
C
Tanabe
T
T
Yoshimoto
T
T
Yamamoto
S
S
D000595:Amino Acid Sequence; D000818:Animals; D001092:Arachidonate 12-Lipoxygenase / Q000737:chemistry; D001093:Arachidonate 15-Lipoxygenase / Q000737:chemistry; D001094:Arachidonate 5-Lipoxygenase / Q000737:chemistry; D005075:Biological Evolution; D006801:Humans; D008084:Lipoxygenase / Q000737:chemistry*; D008969:Molecular Sequence Data; D011451:Prostaglandin-Endoperoxide Synthases / Q000737:chemistry*; D017386:Sequence Homology, Amino Acid
D008084:Lipoxygenase; D001092:Arachidonate 12-Lipoxygenase; D001093:Arachidonate 15-Lipoxygenase; D001094:Arachidonate 5-Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases