title: [5-Fluoro (3H) pyrimidine-4-ones: synthesis, reactivity and pharmacological properties].
abstract: Fourteen fluoro pyrimidine-4-ones, four fluoro bispyrimidine-4-ones and two fluoro pyrimidine-4-ones with fused ring have been prepared. The reactivity of the carbonyl group of two pyrimidine-4-ones phosphorus oxychloride was studied. The 4-chloro pyrimidines reacted with ammonia or morpholine giving 4-substituted pyrimidines. Eight compounds are evaluated for their anti-inflammatory and anti-convulsivant properties: they were found to be weakly active against oedema and three of them protected rats form tonic convulsions.
authors.affiliation: Departamento de Antibioticos, Universidade Federal de Pernambuco, Recife, PE, Brésil.
authors.forename: S J
authors.initials: SJ
authors.lastname: De Melo
authors.forename: C
authors.initials: C
authors.lastname: Luu-Duc
authors.forename: F
authors.initials: F
authors.lastname: Thomasson
authors.forename: G
authors.initials: G
authors.lastname: Narcisse
authors.forename: C
authors.initials: C
authors.lastname: Gaultier
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000494:pharmacology; D000927:Anticonvulsants / Q000138:chemical synthesis; D008297:Male; D051379:Mice; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D011744:Pyrimidinones
vernacular_title: 5-Fluoro (3H) pyrimidine-4-ones: synthèse, réactivité et propriétés pharmacologiques.