title: Continuous positive airway pressure as a promoter of laryngospasm during halothane anesthesia.
abstract: Twenty mongrel dogs were anesthetized with halothane 2.0%, 1.25%, 0.94%, and 0.63% in oxygen. Thyroarytenoid (TA) and posterior cricoarytenoid (PCA) electromyography (EMG) tracings were recorded with the animal at rest, following mechanical irritation of the glottis, and during 20 mm Hg continuous positive airway pressure (CPAP) following either airway occlusion or hyperventilation. Adductor laryngospasm was defined as continuous tonic TA EMG activity, silent PCA EMG, and vocal cord adduction. Abductor laryngospasm was defined as continuous tonic PCA EMG activity, silent TA EMG, and vocal cord abduction. Combined laryngospasm was defined as continuous tonic PCA and TA EMG activity, with variable vocal cord position. The incidence of adductor laryngospasm following mechanical irritation was 30% to 50%. The combined incidence of laryngospasm during application of CPAP following airway occlusion or hyperventilation was 25% to 50%, and differed from the incidence of irritation-induced adductor laryngospasm by 5% or less at the same anesthetic level. Continuous positive airway pressure appears to be a stimulant of laryngeal muscle spasm comparable to mechanical irritation of the glottis.
authors.affiliation: Department of Anesthesiology, Mount Sinai School of Medicine, City University of New York, New York.
authors.forename: D A
authors.initials: DA
authors.lastname: Silva
authors.forename: I
authors.initials: I
authors.lastname: Sanders
mesh_terms: D000402:Airway Obstruction / Q000503:physiopathology; D000769:Anesthesia, Inhalation; D000818:Animals; D001696:Biomechanical Phenomena; D004195:Disease Models, Animal; D004285:Dogs; D005931:Glottis; D006221:Halothane; D006985:Hyperventilation / Q000503:physiopathology; D007826:Laryngismus / Q000209:etiology*; D010812:Physical Stimulation; D011175:Positive-Pressure Respiration / Q000009:adverse effects*
chemical_list: D006221:Halothane