Electro-oculography in autosomal dominant vitreoretinochoroidopathy.
Thirteen members of a family presumed to be harboring the gene for autosomal dominant vitreoretinochoroidopathy were examined. In four affected members, electro-oculography demonstrated marked reduction of the Arden ratio (range, 1.1 to 1.5; normal, > or = 1.8), despite electroretinographic evidence of mildly affected rod function and normal cone function. These findings suggested that a diffuse disturbance of the photoreceptor-pigment epithelium complex may have been present prior to wide-spread loss of photoreceptor function in the affected members of this family. As in previously described families, the pattern of inheritance appeared consistent with autosomal dominance.
Han
D P
DP
Department of Ophthalmology, Medical College of Wisconsin, Milwaukee.
Lewandowski
M F
MF
D000328:Adult; D015862:Choroid Diseases / Q000235:genetics* / Q000503:physiopathology; D003623:Dark Adaptation; D004585:Electrooculography; D004596:Electroretinography; D005128:Eye Diseases / Q000235:genetics / Q000503:physiopathology; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D008027:Light; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012164:Retinal Diseases / Q000235:genetics* / Q000503:physiopathology; D012174:Retinitis Pigmentosa / Q000235:genetics / Q000503:physiopathology; D014822:Vitreous Body / Q000503:physiopathology*