[The carcinogenicity of gasoline (review of the literature)].
In accord with new findings, the gasoline is no more believed to be free of cancerogenic risk. Renal tumours in male rats and those of liver in murine females had been described also after inhalatory exposure to unleaded gasoline. A reliable epidemiological study in occupationally gasoline exposed humans is still not available (higher rate of tumours in workers of chemical petrol processing industry due to the influence of gasoline appears to be an indirect proof, because apart from gasoline also other substances are involved simultaneously). With regard to a mechanism of action, those first published have been the negative results of testing for chromosomal abnormalities and bacterial genetic mutations. However, the mutagenicity was proved further on molecular level with the use of appropriate tests (e. g. induction of DNA repair synthesis). Certain authors ascribe more importance to the promotional rather than initiational effect of gasoline. However, the former is not accentuated by the IARC. Further studies should be predominantly based on molecular genetic approaches and epidemiological studies.
Hochmann
J
J
D000818:Animals; D002273:Carcinogens; D005742:Gasoline / Q000009:adverse effects*; D006801:Humans
D002273:Carcinogens; D005742:Gasoline
Karcinogenita benzínu (prehled literárních údajů).