Adriamycin-induced inhibition of arachidonate incorporation into phospholipids of mastocytoma P815 cells.
Adriamycin inhibited [1-14C]-arachidonic acid uptake by mastocytoma P815 cells in a dose-dependent manner (5-120 nM). The incorporation of [1-14C]-arachidonic acid into phospholipids was decreased mainly into cardiolipin and phosphatidylcholine.
Kondakova
I V
IV
Department of Immunology, Tomsk Scientific Centre, Russian Academy of Medical Sciences.
Vereschagina
S V
SV
Borunov
E V
EV
D000107:Acetylation / Q000187:drug effects; D000818:Animals; D016718:Arachidonic Acid / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002250:Carbon Radioisotopes; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000494:pharmacology*; D012515:Mast-Cell Sarcoma / Q000188:drug therapy / Q000378:metabolism*; D051379:Mice; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D010743:Phospholipids / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D002250:Carbon Radioisotopes; D010743:Phospholipids; D016718:Arachidonic Acid; D004317:Doxorubicin