Pharmacology, bio-analysis and pharmacokinetics of the vinca alkaloids and semi-synthetic derivatives (review).
Vinca alkaloids have been used as chemotherapeutic agents now for over three decades. Especially during recent years, the development of a considerable number of semi-synthetic derivatives, showing attractive properties in preclinical or clinical investigations, has been reported. In this paper we shall give a critical review of the investigations presented on this matter.
van Tellingen
O
O
Department of Clinical Chemistry, Netherlands Cancer Institute, Amsterdam.
Sips
J H
JH
Beijnen
J H
JH
Bult
A
A
Nooijen
W J
WJ
D000818:Animals; D001692:Biological Transport; D006801:Humans; D013329:Structure-Activity Relationship; D014748:Vinca Alkaloids / Q000378:metabolism / Q000493:pharmacokinetics* / Q000494:pharmacology*
D014748:Vinca Alkaloids