Granule proteins of the dental follicle and stellate reticulum inhibit tooth eruption and eyelid opening in postnatal rats.
Electron-dense granules within cells of the dental follicle and stellate reticulum of rat mandibular molars can be isolated; their major components are 167 and 200 kDa proteins. Injecting these granule proteins into postnatal rats results in a delay of incisor eruption and eyelid separation. These inhibitory effects were most pronounced with the 167 kDa protein (a delay of 3 days in incisor eruption and of 2 days in eyelid opening) and were opposite to the stimulatory effects of epidermal growth factor. Thus, these granules may play an inhibitory part in tooth eruption.
Lin
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Department of Anatomy and Cell Biology, Texas College of Osteopathic Medicine/University of North Texas, Fort Worth 76107-2690.
Fan
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Wise
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D000818:Animals; D000831:Animals, Newborn; D003594:Cytoplasmic Granules / Q000737:chemistry; D003795:Dental Sac / Q000737:chemistry*; D066246:ErbB Receptors / Q000187:drug effects*; D005143:Eyelids / Q000187:drug effects; D008970:Molecular Weight; D011506:Proteins / Q000494:pharmacology*; D051381:Rats; D014078:Tooth Eruption / Q000187:drug effects*
D011506:Proteins; D066246:ErbB Receptors