title: Oscillations and waves of cytosolic calcium: insights from theoretical models.
abstract: Oscillations in cytosolic Ca2+ occur in a wide variety of cells, either spontaneously or as a result of external stimulation. This process is often accompanied by intracellular Ca2+ waves. A number of theoretical models have been proposed to account for the periodic generation and spatial propagation of Ca2+ signals. These models are reviewed and their predictions compared with experimental observations. Models for Ca2+ oscillations can be distinguished according to whether or not they rely on the concomitant, periodic variation in inositol 1,4,5-trisphosphate. Such a variation, however, is not required in models based on Ca(2+)-induced Ca2+ release. When Ca2+ diffusion is incorporated into these models, propagating waves of cytosolic Ca2+ arise, with profiles and rates comparable to those seen in the experiments.
authors.affiliation: Faculté des Sciences, Université Libre de Bruxelles, Belgium.
authors.forename: G
authors.initials: G
authors.lastname: Dupont
authors.forename: A
authors.initials: A
authors.lastname: Goldbeter
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D004727:Endothelium / Q000378:metabolism; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008954:Models, Biological; D009206:Myocardium / Q000378:metabolism; D009865:Oocytes / Q000378:metabolism; D010507:Periodicity; D051381:Rats; D015398:Signal Transduction; D014982:Xenopus laevis / Q000196:embryology / Q000378:metabolism; D015053:Zygote / Q000378:metabolism
chemical_list: D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium