Ultrastructural analysis of platelet contractile apparatus.
Methods for evaluating the organization, subcellular distribution, and rearrangements in specific constituents of the platelet contractile cytoskeleton are rapidly being developed. The procedures presented and discussed here have yielded useful information. However, a great deal more is required before the role of contractile elements of the cytoskeleton in platelet physiology will be fully understood. The new approaches employing better preservation of platelet structure and immunocytochemistry will undoubtedly provide this knowledge in the near future.
White
J G
JG
Department of Laboratory Medicine, University of Minnesota Medical School, Minneapolis 55455.
D000199:Actins / Q000097:blood / Q000648:ultrastructure; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure*; D003018:Clot Retraction; D003599:Cytoskeleton / Q000648:ultrastructure*; D006801:Humans; D008854:Microscopy, Electron; D008870:Microtubules / Q000648:ultrastructure; D013917:Thrombin / Q000494:pharmacology
D000199:Actins; D013917:Thrombin