[The generation of active forms of oxygen by the blood leukocytes, lipid peroxidation and antiperoxide protection in bronchial asthma patients].
A study was made of the generation of active forms of oxygen by leukocytes, of free radical lipid peroxidation and antiperoxide activity (APA) in 52 bronchial asthma (BA) patients depending on the disease phase and of a possibility of their correction with antioxidants. In BA exacerbation, chemiluminescence of leukocytes (CL) and plasma content of malonic dialdehyde (MDA) increase whereas plasma APA reduces as compared to the control. During remission, CL and plasma content of MDA decrease but do not reach normal. Simultaneously one can see a tendency toward plasma APA reduction as compared with the phase of exacerbation. BA patients who received antioxidants in addition to the conventional therapy demonstrated a more pronounced lowering of CL and plasma MDA content than those given the conventional therapy alone. The data obtained attest to the activation of free radical oxygen and lipid processes and to inhibition of plasma APA in BA, providing evidence in favour of including antioxidants in combined therapy of BA.
Daniliak
I G
IG
KOgan
A Kh
AKh
Bolevich
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000975:Antioxidants; D001249:Asthma / Q000097:blood* / Q000628:therapy; D005260:Female; D005609:Free Radicals; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D015227:Lipid Peroxidation; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D012074:Remission Induction
D000975:Antioxidants; D005609:Free Radicals; D010100:Oxygen
Generatsiia aktivnykh form kisloroda leĭkotsitov krovi, perekisnoe okislenie lipidov i antiperekisnaia zashchita u bol'nykh bronkhial'noĭ astmoĭ.