Core structure of glycyrrhizan GA, the main polysaccharide from the stolon of Glycyrrhiza glabra var. glandulifera; anti-complementary and alkaline phosphatase-inducing activities of the polysaccharide and its degradation products.
The controlled Smith degradation and limited hydrolysis of glycyrrhizan GA, a representative polysaccharide with remarkable phagocytosis-enhancing activity isolated from the stolon of Glycyrrhiza glabra L. var. glandulifera Reg. et Herd. were carried out. Methylation analyses of the primary and the secondary Smith degradation products and of the limited hydrolysis product indicated that the core structural features of glycyrrhizan GA include a backbone chain composed of beta-1,3-linked D-galactose residues. Three-fifths of the galactose units in the backbone carry side chains composed of beta-1,3- and beta-1,6-linked D-galactosyl residues at position 6. Anti-complementary and alkaline phosphatase-inducing activities of the polysaccharide, periodate oxidation-reduction and the controlled Smith degradation products were investigated, and the controlled Smith degradation product showed significant activity.
Takada
K
K
Kyoritsu College of Pharmacy, Tokyo, Japan.
Tomoda
M
M
Shimizu
N
N
D000469:Alkaline Phosphatase / Q000096:biosynthesis*; D003169:Complement Inactivator Proteins / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D006035:Glycyrrhiza / Q000737:chemistry*; D019695:Glycyrrhizic Acid; D010946:Plants, Medicinal
D003169:Complement Inactivator Proteins; D019695:Glycyrrhizic Acid; D000469:Alkaline Phosphatase; D006034:Glycyrrhetinic Acid