[The antithromboxane activity of alpha- and omega-modified carbocyclic analogs of PGH1].
In in vitro experiments on a model of arachidonate- and thrombin-induced platelet aggregation, analogues of PG endoperoxides displayed an antiaggregatory effect or stimulated spontaneous platelet aggregation in the whole blood of man and rabbits, but a slight antiaggregatory effect in the rabbit intact organism. The presence of the hydroxyl group instead of the routine alkyl omega-chain produced an antiaggregatory effect due to TxA2 receptor blockade.
Kuz'mitskiĭ
B B
BB
Bondar'
N F
NF
Malaeva
L P
LP
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D011450:Prostaglandin Endoperoxides, Synthetic / Q000494:pharmacology*; D011463:Prostaglandins H / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D017482:Receptors, Thromboxane / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship; D013928:Thromboxane A2 / Q000037:antagonists & inhibitors*
D010975:Platelet Aggregation Inhibitors; D011450:Prostaglandin Endoperoxides, Synthetic; D011463:Prostaglandins H; D017482:Receptors, Thromboxane; D013928:Thromboxane A2
Antitromboksanovaia aktivnost' al'fa- i omega-modifitsirovannykh karbotsiklicheskikh analogov PGH1.