Serum elimination half-life of tamoxifen and its metabolites in patients with advanced breast cancer.
In breast cancer patients discontinuing chronic tamoxifen therapy, the serum elimination of metabolites X, Y and E paralleled that of tamoxifen, whereas that of metabolite Z did not. The serum elimination of tamoxifen and metabolites X and B was increased by amino-glutethimide treatment, whereas that of metabolites Z, Y, and E was not.
de Vos
D
D
Medical Department, Pharmachemie B.V., Haarlem, The Netherlands.
Slee
P H
PH
Stevenson
D
D
Briggs
R J
RJ
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000097:blood / Q000378:metabolism*; D004334:Drug Administration Schedule; D005260:Female; D006207:Half-Life; D006801:Humans; D008875:Middle Aged; D013629:Tamoxifen / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*
D013629:Tamoxifen