title: Glycinergic interventions potentiate the ability of MK 801 to raise the threshold voltage for tonic hindlimb extension in mice.
abstract: Milacemide, an acylated prodrug of glycine, was able to increase the efficacy with which [+]-5-methyl-10,11-dihydro-5h-dibenzo[a,d]cyclohepten-5,10-imine meleate (MK 801) antagonized the electrical precipitation of seizures in mice. The mechanism of milacemide's potentiation of MK 801's antiseizure efficacy in intact mice is unclear; however, a glycine agonist selective for the strychnine-insensitive site on the NMDA receptor complex was also able to potentiate MK 801. The exciting possibility exists that an exogenous glycinergic intervention can potentiate NMDA-mediated neural transmission in intact animals.
authors.affiliation: Psychiatry Service, Department of Veterans Affairs Medical Center, Washington, DC 20422.
authors.forename: D O
authors.initials: DO
authors.lastname: Norris
authors.forename: J
authors.initials: J
authors.lastname: Mastropaolo
authors.forename: D A
authors.initials: DA
authors.lastname: O'Connor
authors.forename: M R
authors.initials: MR
authors.lastname: Novitzki
authors.forename: S I
authors.initials: SI
authors.lastname: Deutsch
mesh_terms: D000081:Acetamides / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003523:Cycloserine / Q000494:pharmacology; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004558:Electric Stimulation; D004597:Electroshock; D005998:Glycine / Q000502:physiology*; D006614:Hindlimb / Q000502:physiology; D008297:Male; D051379:Mice; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D012018:Reflex / Q000187:drug effects*
chemical_list: D000081:Acetamides; D008996:Monoamine Oxidase Inhibitors; C039332:milacemide; D016291:Dizocilpine Maleate; D003523:Cycloserine; D005998:Glycine