title: Clinical response of alopecia, trichorrhexis nodosa, and dry, scaly skin to zinc supplementation.
abstract: Two unrelated patients had dry brittle hair, alopecia, trichorrhexis nodosa, dry scaly skin, pigment dyschromia, short stature, and neurosecretory growth hormone deficiency. By means of the zinc tolerance test, patient 1 was shown to have zinc deficiency, whereas no clear zinc deficiency could be demonstrated in patient 2. In both patients, hair and the skin abnormalities responded to oral zinc therapy.
authors.affiliation: Department of Pediatrics, North Shore University Hospital-Cornell University Medical College, Manhasset, NY 11030.
authors.forename: A E
authors.initials: AE
authors.lastname: Slonim
authors.forename: N
authors.initials: N
authors.lastname: Sadick
authors.forename: M
authors.initials: M
authors.lastname: Pugliese
authors.forename: C H
authors.initials: CH
authors.lastname: Meyers-Seifer
mesh_terms: D000505:Alopecia / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D006130:Growth Disorders / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D013006:Growth Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000172:deficiency / Q000378:metabolism; D006197:Hair / Q000187:drug effects / Q000473:pathology; D006201:Hair Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D006728:Hormones / Q000008:administration & dosage; D019382:Human Growth Hormone; D006801:Humans; D008297:Male; D012867:Skin / Q000187:drug effects / Q000473:pathology; D012871:Skin Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D012880:Skin Pigmentation / Q000187:drug effects; D013431:Sulfates / Q000008:administration & dosage; D015032:Zinc / Q000008:administration & dosage* / Q000032:analysis / Q000172:deficiency; D019287:Zinc Sulfate
chemical_list: D006728:Hormones; D013431:Sulfates; D019382:Human Growth Hormone; D019287:Zinc Sulfate; D013006:Growth Hormone; D015032:Zinc