title: The enzymology of archaebacterial pathways of central metabolism.
abstract: From a comparison of the pathways of central metabolism in the archaebacteria, eubacteria and eukaryotes, it is clear that the basic pathways were established before the divergence of the three kingdoms, but that the notable differences may provide important clues to their evolution. From these comparisons, enzymes found in all evolutionary groups have been chosen for detailed structural studies; given the range of extreme phenotypes found within the archaebacteria, these studies will be crucial to our understanding of the structural basis for protein stability and how such features may be engineered into a protein of choice.
authors.affiliation: Department of Biochemistry, University of Bath, U.K.
authors.forename: M J
authors.initials: MJ
authors.lastname: Danson
authors.forename: D W
authors.initials: DW
authors.lastname: Hough
mesh_terms: D001105:Archaea / Q000201:enzymology* / Q000378:metabolism*