Anethofuran, carvone, and limonene: potential cancer chemopreventive agents from dill weed oil and caraway oil.
Bioassay-directed fractionation of dill weed oil and caraway oil, respectively, from the plants Anethum graveolens L. and Carum carvi L. (Umbelliferae) has led to the isolation of three monoterpenes, anethofuran (1), carvone (2), and limonene (3). Their structures were determined on the basis of spectral analysis. These compounds induced the detoxifying enzyme glutathione S-transferase in several mouse target tissues. The alpha,beta-unsaturated ketone system in carvone appeared to be critical for the high enzyme-inducing activity.
Zheng
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LKT Laboratories Inc., Minneapolis, Minnesota 55413.
Kenney
P M
PM
Lam
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LK
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D001572:Benzofurans / Q000302:isolation & purification / Q000494:pharmacology*; D000081005:Cyclohexane Monoterpenes; D053138:Cyclohexenes; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D005982:Glutathione Transferase / Q000096:biosynthesis; D000077222:Limonene; D051379:Mice; D039821:Monoterpenes; D010938:Plant Oils / Q000737:chemistry*; D013729:Terpenes / Q000302:isolation & purification / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D001572:Benzofurans; D000081005:Cyclohexane Monoterpenes; D053138:Cyclohexenes; D039821:Monoterpenes; D010938:Plant Oils; D013729:Terpenes; C077702:anethofuran; C006923:carvone; D000077222:Limonene; D005982:Glutathione Transferase