title: Evaluation of some newer non-steroidal anti-inflammatory indan-1-acids in various biological systems.
abstract: In line of the effort towards development of some newer indanyl non-steroidal anti-inflammatory agents and providing comprehensive SAR among this class of compounds some significantly active derivatives with low ulcerogenic potential were identified. Dealing with various long chain and branched chain compounds among this series, 3-(5, 6-dimethoxy indan-1-yl) propionic acid, 2-(5, 6-dimethoxy indan-1-yl) propionic acid and 3-(6-methoxy indan-1-yl) propionic acid were observed to have encouraging biological activity. Screening in various animal models of inflammation suggests their longer duration of action and lower ulcerogenic liability.
authors.affiliation: Department of Chemical Technology, University College of Science and Technology, Calcutta University, India.
authors.forename: A
authors.initials: A
authors.lastname: Mukhopadhyay
authors.forename: S C
authors.initials: SC
authors.lastname: Lahiri
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000494:pharmacology* / Q000633:toxicity; D001169:Arthritis, Experimental / Q000188:drug therapy; D001831:Body Temperature / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000188:drug therapy; D005069:Evaluation Studies as Topic; D007189:Indans / Q000009:adverse effects / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D010146:Pain / Q000188:drug therapy; D010437:Peptic Ulcer / Q000139:chemically induced; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007189:Indans