p53 protein in odontogenic cysts: increased expression in some odontogenic keratocysts.
OBJECTIVE
To assess p53 protein expression in a range of odontogenic cysts arising in the mouth, including those of developmental and inflammatory origin.


METHODS
p53 protein was identified using the polyclonal antibody CM-1, together with a standard immunoperoxidase technique. A total of 36 cystic lesions were examined, all of which were histologically benign.


RESULTS
Expression of p53 protein was identified within the lining of five of 12 odontogenic keratocysts but was not detected in the other cystic lesions in the series.


CONCLUSIONS
This is believed to be the first report that identifies increased expression of p53 protein in benign cystic epithelium. The increased expression of p53 protein in the nucleus is usually associated with malignant disease. These findings are relevant to the management of odontogenic keratocysts which have a tendency to recur, and also to Gorlin Goltz syndrome in which keratocysts and multiple basal cell carcinomas are features.
Ogden
G R
GR
Department of Dental Surgery, Dental Hospital and School, Dundee University, Scotland.
Chisholm
D M
DM
Kiddie
R A
RA
Lane
D P
DP
D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008336:Mandibular Diseases / Q000378:metabolism*; D008439:Maxillary Diseases / Q000378:metabolism*; D008875:Middle Aged; D009807:Odontogenic Cysts / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D016159:Tumor Suppressor Protein p53