Near fatal liver dysfunction secondary to administration of flutamide for prostate cancer.
A 66-year-old man with metastatic prostate cancer was treated with bilateral orchiectomy and 750 mg. flutamide per day. Near fatal liver dysfunction developed 10 weeks later. Flutamide was discontinued and 8 weeks later liver enzymes had returned to normal.
Dankoff
J S
JS
Department of Urology, Northeastern Ohio Universities, College of Medicine, Akron.
D000368:Aged; D056486:Chemical and Drug Induced Liver Injury; D005485:Flutamide / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy*
D005485:Flutamide