Transmission blocking antibody of the Plasmodium falciparum zygote/ookinete surface protein Pfs25 also influences sporozoite development.
The Plasmodium falciparum zygote/ookinete surface protein, Pfs25, persists in the oocyst wall throughout its development. Anti-25 kD transmission blocking antibody, given to infected Anopheles stephensi or A. gambiae mosquitoes in an additional bloodmeal, 3-6 days after being fed gametocyte infected blood, penetrated the oocyst and reacted with the 25 kD protein within it. This reaction caused a significant reduction in the number of developing sporozoites. Mouse serum containing antibodies raised by immunization with a recombinant 25 kD yeast product showed a similar effect.
Lensen
A H
AH
Department of Parasitology, University of Nijmegen, The Netherlands.
Van Gemert
G J
GJ
Bolmer
M G
MG
Meis
J F
JF
Kaslow
D
D
Meuwissen
J H
JH
Ponnudurai
T
T
D000818:Animals; D000852:Anopheles / Q000469:parasitology; D000913:Antibodies, Protozoan / Q000008:administration & dosage; D000953:Antigens, Protozoan; D000954:Antigens, Surface; D016782:Apicomplexa / Q000254:growth & development / Q000276:immunology / Q000648:ultrastructure; D001667:Binding, Competitive; D007114:Immunization; D051379:Mice; D010963:Plasmodium falciparum / Q000276:immunology*; D015800:Protozoan Proteins / Q000276:immunology; D011994:Recombinant Proteins / Q000276:immunology
D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D000954:Antigens, Surface; C071284:Pfs25 protein, Plasmodium falciparum; D015800:Protozoan Proteins; D011994:Recombinant Proteins