[Circadian rhythm of blood pressure in renovascular hypertensive goats treated with captopril].
Blood pressure (BP) was recorded directly and automatically by a microcomputer aid system for 48 h in normotensive and Goldblatt hypertensive goats. By population-mean cosinor fitting, significant circadian rhythms were found for SBP and DBP in both groups of goats. The BP during nighttime was higher than that during daytime in our goats. An angiotensin converting enzyme inhibitor, captopril, was given to hypertensive goats with usual schedule of drug administration (25mg, t.i.d) or form of chronotherapy (62.5 mg, given before the acrophase of BP, q.n). BP significantly decreased throughout the whole day in both treated groups. But there was no statistical difference of cosinor parameters between the effects of BP in these two groups. BP could be decreased by the method of chronotherapy with less amount of drug and less frequency of drug administration.
Qiu
H
H
Wang
D
D
Xiao
J
J
Luo
H
H
Chen
H
H
Xue
Z
Z
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002216:Captopril / Q000627:therapeutic use*; D002940:Circadian Rhythm; D006041:Goats; D006978:Hypertension, Renovascular / Q000188:drug therapy* / Q000503:physiopathology*; D008297:Male; D013997:Time Factors
D002216:Captopril