[Signal transduction in normal and neoplastic cells].
This review describes molecular mechanisms involved in intracellular signal transmission. Special focus is given on calcium and calcium binding proteins as signaling intermediates. These strictly controlled biochemical reactions prevent uncoordinated proliferation which may lead to tumor development. Generally, signal transduction pathways are very similar among higher eukaryotes. Mutations in genes responsible for signal transmission and growth control (protooncogenes and tumor suppressor genes) are often found in tumors or cancer cell lines.
Berchtold
M W
MW
Institut für Pharmakologie und Biochemie, Veterinär-Medizinische Fakultät, Universität Zürich.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism; D002450:Cell Communication; D002453:Cell Cycle; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology*; D015398:Signal Transduction; D014407:Tumor Cells, Cultured
D002135:Calcium-Binding Proteins; D002118:Calcium
Signalübermittlung in normalen und krebsartigen Zellen.