title: Retinal ischemia induced by occlusion of both common carotid arteries in rats as demonstrated by electroretinography.
abstract: In 2 models of reduced cerebral blood flow-permanent occlusion of the vertebral arteries plus transient occlusion of the common carotid arteries (4VO) and transient clamping of the common carotid arteries (BCCA)-the acute effects on the electrical function of the retina were monitored by recording the photopic electroretinogram. During both 4VO and BCCA the amplitude of the b-wave was reduced. Within 30 min of reperfusion after 4VO and after BCCA the b-wave had fully recovered. In contrast, the a-wave was not affected by either treatment. The data suggest that occlusion of common carotid arteries leads to retinal ischemia and might represent a useful model of amaurosis fugax.
authors.affiliation: Department of Neurology, University of Essen, FRG.
authors.forename: F
authors.initials: F
authors.lastname: Block
authors.forename: M
authors.initials: M
authors.lastname: Schwarz
authors.forename: K H
authors.initials: KH
authors.lastname: Sontag
mesh_terms: D000818:Animals; D017536:Carotid Artery, Common / Q000502:physiology*; D004594:Electrophysiology; D004596:Electroretinography; D007511:Ischemia / Q000473:pathology*; D002546:Ischemic Attack, Transient / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012160:Retina / Q000473:pathology; D012171:Retinal Vessels / Q000502:physiology*