Increased serum N-acetyl-beta-D-glucosaminidase and alpha-D-mannosidase activities in obese subjects.
We have studied N-acetyl-beta-D-glucosaminidase and alpha-D-mannosidase activities in human sera from 35 control subjects, 47 normo- and hyperinsulinemic obese persons, and 12 diabetic patients after a fasting period of 12 h and at 30, 60, 90, and 120 min after an oral glucose overload. The results show a significantly higher activity of these 2 enzymes in obese subjects and diabetic patients, of similar magnitude, especially in those obese persons with a higher grade of obesity. Moreover, the activity of these glycosidases decreases in a similar way in all these 3 groups after the oral glucose overload.
Corral
J
J
Departamento de Bioquímica y Biología Molecular, Facultad de Biología, Universidad de Salamanca.
Miralles
J M
JM
García-Pascual
I J
IJ
Corrales
J J
JJ
García-Sastre
A
A
Villar
E
E
D000118:Acetylglucosaminidase / Q000097:blood*; D003920:Diabetes Mellitus / Q000201:enzymology*; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology*; D005951:Glucose Tolerance Test; D006801:Humans; D006946:Hyperinsulinism / Q000201:enzymology*; D008361:Mannosidases / Q000097:blood*; D009765:Obesity / Q000201:enzymology*; D043323:alpha-Mannosidase
D008361:Mannosidases; D043323:alpha-Mannosidase; D000118:Acetylglucosaminidase