title: Evaluation of plant extracts for antileishmanial activity using a mechanism-based radiorespirometric microtechnique (RAM).
abstract: Extracts of eleven plants used in Nigerian traditional medicine have been evaluated for possible antileishmanial activity using a radiorespirometric microtest technique based on in vitro inhibition of catabolism of 14CO2 from a battery of 14C-substrates by promastigotes. Of 13 methanol extracts tested, 5 from Gongronema latifolia, Dorstenia multiradiata, Picralima nitida, Cola attiensis, and Desmodium gangeticum, were active at concentrations of 50 micrograms/ml or less against a visceral Leishmania isolate.
authors: Department of Medicinal Chemistry, Walter Reed Army Institute of Research, Washington, D.C. 20307.
authors: M M
authors: MM
authors: Iwu
authors: J E
authors: JE
authors: Jackson
authors: J D
authors: JD
authors: Tally
authors: D L
authors: DL
authors: Klayman
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002245:Carbon Dioxide / Q000378:metabolism; D007891:Leishmania / Q000187:drug effects* / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000981:Antiprotozoal Agents; D010936:Plant Extracts; D002245:Carbon Dioxide