[The functional properties of the erythrocyte membranes in patients with chronic glomerulonephritis].
Mg-, Ca-, Na-, K-ATPase, acetylcholine esterase and sulfhydryl groups of red blood cell membranes were evaluated in 40 patients with chronic glomerulonephritis in preazotemia stage versus 34 healthy controls. In chronic glomerulonephritis there was a significant fall in Ca-ATPase activity irrespective of the disease pattern. Na, K-ATPase tended tot a decrease contrary to sulfhydryl groups levels and acetylcholine esterase activity. In the nephrotic variant of the disease Na, K-ATPase, Ca-ATPase activity dropped and came to increase due to glucocorticosteroid treatment. The changes are attributed to modification of the lipid bilayer of the red blood cell membranes.
Rakhov
D A
DA
Iudanova
L S
LS
Rubin
V I
VI
D000110:Acetylcholinesterase / Q000097:blood; D000251:Adenosine Triphosphatases / Q000097:blood; D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D004910:Erythrocyte Membrane / Q000502:physiology*; D005921:Glomerulonephritis / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D013438:Sulfhydryl Compounds / Q000097:blood; D014511:Uremia / Q000097:blood
D013438:Sulfhydryl Compounds; D000110:Acetylcholinesterase; D000251:Adenosine Triphosphatases
Funktsional'nye svoĭstva membran éritrotsitov u bol'nykh khronicheskim glomerulonefritom.