Effects of topically applied 2% epinephrine and 0.1% dipivalyl epinephrine on the adrenergic nerves as revealed by histofluorescence.
Commercially available epinephrine (EPI) 2% and dipivalyl epinephrine (DPE) 0.1% ophthalmic solutions were instilled twice daily in the eyes of rats over a 12-week period and compared to placebo-vehicle-treated controls. Fluorescence photomicrographs of stretch preparations from the dilator muscle of the rat irises showed a weaker fluorescence in the eyes treated with EPI and DPE as compared with controls treated with a placebo vehicle. This study provides further evidence that EPI and DPE treatment can result in a chemical sympathectomy as has been described following topical application of 6-hydroxydopamine.
Flach
A J
AJ
Department of Veterans Affairs, Medical Center, San Francisco, Calif.
Donahue
M E
ME
D000818:Animals; D004837:Epinephrine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006652:Histological Techniques; D007498:Iris / Q000294:innervation*; D008297:Male; D008856:Microscopy, Fluorescence; D009883:Ophthalmic Solutions / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013563:Sympathectomy, Chemical; D013564:Sympathetic Nervous System / Q000187:drug effects*
D009883:Ophthalmic Solutions; C015173:dipivefrin; D004837:Epinephrine