title: [Free-radical mechanism of antimicrobial action of xanthine oxidase and lactoperoxidase].
abstract: The interaction between milk xanthine oxidase (XO) and lactoperoxidase (LP) in model system and antimicrobial action of these enzymes on Escherichia coli 0-111 were studied. It was shown, that bacterial superoxide dismutase (SOD), which transforms O2-. (XO-reaction product) into H2O2 (substrate of LP), is necessary for binding of the reaction sequence: XO-->LP-->antimicrobial products. It is suggested, that these enzymes unite in the protective system in intestinal infections of newborns. Bacterial SOD in this case acts as the key factor, creating the system.
authors: D V
authors: DV
authors: Al'perovich
authors: E V
authors: EV
authors: Kesel'man
authors: A P
authors: AP
authors: Shepelev
authors: L N
authors: LN
authors: Chernavskaia
mesh_terms: D000818:Animals; D002417:Cattle; D004926:Escherichia coli / Q000201:enzymology / Q000276:immunology*; D005609:Free Radicals; D007784:Lactoperoxidase / Q000276:immunology*; D008892:Milk / Q000201:enzymology* / Q000276:immunology; D013482:Superoxide Dismutase / Q000276:immunology*; D014969:Xanthine Oxidase / Q000276:immunology*
chemical_list: D005609:Free Radicals; D007784:Lactoperoxidase; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase
vernacular_title: Svobodno-radikal'nyĭ mekhanizm antimikrobnogo deĭstviia ksantinoksidazy i laktoperoksidazy.