Features of an autoimmune process in mid-dermal elastolysis.
Mid-dermal elastolysis is a rare disorder that is manifested clinically by wrinkling and histologically by the selective absence of elastic fibers in the mid dermis. We describe a young woman who developed abnormal wrinkling after augmentation mammoplasty with silicone implants. Histologic examination confirmed the diagnosis of mid-dermal elastolysis. In addition, a positive antinuclear antibody titer and a false-positive Lyme titer were subsequently detected. In a previously reported case a patient who had mid-dermal elastolysis also had an unusual false-positive pattern for Lyme disease. Silicone mammoplasty has been associated with connective tissue diseases. This report adds mid-dermal elastolysis to the list of diseases associated with augmentation mammoplasty and, along with the presence of autoantibodies, supports autoimmune involvement in mid-dermal elastolysis.
Kirsner
R S
RS
Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, FL 33136.
Falanga
V
V
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis*; D003483:Cutis Laxa / Q000276:immunology*; D004547:Elastic Tissue / Q000276:immunology* / Q000473:pathology; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008193:Lyme Disease / Q000175:diagnosis / Q000276:immunology; D016462:Mammaplasty / Q000009:adverse effects; D019736:Prostheses and Implants / Q000009:adverse effects; D015595:Skin Aging / Q000276:immunology / Q000473:pathology
D000974:Antibodies, Antinuclear