Regulation of isotype switching.
In the past year, our understanding of the mechanisms that regulate isotype switching has significantly progressed. Activation of germ line transcription by isotype-specific cytokines is emerging as a crucial mechanism for increasing the accessibility of a particular switch region, and targeting switch recombination.
Vercelli
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Division of Immunology, Children's Hospital, Boston, Massachusetts 02115.
Geha
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RS
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000235:genetics / Q000276:immunology; D007073:Immunoglobulin E / Q000235:genetics / Q000276:immunology; D007132:Immunoglobulin Isotypes / Q000235:genetics*; D007134:Immunoglobulin Switch Region
D007070:Immunoglobulin A; D007132:Immunoglobulin Isotypes; D007073:Immunoglobulin E