Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view.
This new view of the immunoreactivity of the normal brain is based on three key components. First, there is an active and highly-regulated communication between the brain and the central immune organs. Secondly, the connection from the brain to the draining nodes is much larger than previously appreciated. And third, the blood-brain barrier, by virtue of its selective permeability properties, contributes to the regulation of immunoregulatory cells and molecules in the brain cell microenvironment.
Cserr
H F
HF
Section of Physiology, Brown University, Providence, RI 02912.
Knopf
P M
PM
D000418:Albumins / Q000378:metabolism; D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000008:administration & dosage; D001402:B-Lymphocytes / Q000276:immunology; D001812:Blood-Brain Barrier / Q000276:immunology*; D001921:Brain / Q000276:immunology*; D002465:Cell Movement; D002555:Cerebrospinal Fluid / Q000502:physiology; D005110:Extracellular Space / Q000502:physiology; D007276:Injections, Intraventricular; D008196:Lymph / Q000502:physiology*; D051381:Rats
D000418:Albumins; D000941:Antigens