[Severe malaria attacks in adults in Cameroon: comparison of 2 therapeutic protocols using quinine via parenteral route].
Increasing frequency and severity of cerebral malaria have become a major problem in the area of Yaoundé (Cameroon, Central Africa). Based on recent findings in pharmacokinetic parameters in cerebral malaria, a quinine infusion regimen (8 mg of quinine base/kg of body weight over 1 h followed by 8 mg of base/kg over 7 h, then 8 mg/kg over 8 h 3 times daily for 3 days) was randomly allocated to 10 patients; 10 others received a more classical regimen currently used in Cameroon of 8 mg of base/kg over 8 h, 3 times daily for 3 days. In the loading dose group, there was a significant decrease in the duration of coma (48%), and the parasite clearance times were reduced by 33%. This regimen has been safe and effective: it is recommended in Yaoundé.
Louis
F J
FJ
Services des Laboratoires, OCEAC, Yaoundé, Cameroun.
Fargier
J J
JJ
Maubert
B
B
Louis
J P
JP
Hounsinou
C
C
Le Bras
J
J
Touzé
J E
JE
D000328:Adult; D002163:Cameroon / Q000453:epidemiology; D002985:Clinical Protocols; D004305:Dose-Response Relationship, Drug; D015600:Glasgow Coma Scale; D006801:Humans; D007263:Infusions, Parenteral; D016779:Malaria, Cerebral / Q000188:drug therapy* / Q000453:epidemiology; D016778:Malaria, Falciparum / Q000188:drug therapy*; D011803:Quinine / Q000008:administration & dosage*
D011803:Quinine
Accès palustre grave de l'adulte au Cameroun: comparaison de deux protocoles therapeutiques utilisant la quinine par voie parentérale.