Central arrhythmogenic effects of N-methyl-D-aspartate (NMDA) in anesthetized rats: influence of the denervation of the carotid-sinus baroreceptors on the susceptibility to arrhythmias.
The intracerebroventricular (i.c.v.) administration of NMDA into urethane anesthetized rats could induce centrogenic cardiac arrhythmias. There were some important differences between sodium glutamate- and NMDA-induced arrhythmias which rendered it difficult to accept the assumption that glutamate-induced arrhythmias were due to the stimulation of only NMDA receptors. Denervation of the carotid-sinus baroreceptor zones enhanced the central arrhythmogenic activity of both sodium glutamate and NMDA.
Berrino
L
L
Institute of Pharmacology and Toxicology, First Faculty of Medicine and Surgery, University of Naples Federico II, Italy.
Cuparencu
B
B
de Novellis
V
V
Stella
L
L
Magrella
M
M
Rossi
F
F
D000758:Anesthesia; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000503:physiopathology*; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D002346:Carotid Sinus / Q000294:innervation*; D003714:Denervation; D004198:Disease Susceptibility; D004562:Electrocardiography; D005260:Female; D007276:Injections, Intraventricular; D008297:Male; D016202:N-Methylaspartate / Q000008:administration & dosage / Q000494:pharmacology*; D011311:Pressoreceptors / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012970:Sodium Glutamate / Q000494:pharmacology; D014520:Urethane / Q000008:administration & dosage
D014520:Urethane; D016202:N-Methylaspartate; D012970:Sodium Glutamate