[Hyponatremia during therapy of von Willebrand's disease. A life threatening complication after desmopressin (Minitrin) infusion].
We describe a patient with moderate von Willebrand's disease who developed severe hyponatremia during prophylaxis with 1-deamino-8D-arginine vasopressin (desmopressin) to prevent bleeding in connection with surgery. This is a rare complication to desmopressin treatment in adults. Our present policy is to restrict administration of desmopressin to three 12-hourly infusions, to measure serum sodium before and during the treatment period, to determine body weight daily and to restrict administration of fluids.
Brinch
L J
LJ
Hematologisk seksjon, Rikshospitalet, Oslo.
Jacobsen
M B
MB
D000328:Adult; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced*; D007262:Infusions, Intravenous; D011292:Premedication; D014842:von Willebrand Diseases / Q000097:blood / Q000188:drug therapy*
D003894:Deamino Arginine Vasopressin
Hyponatremi ved behandling av von Willebrands sykdom. Livstruende komplikasjon etter desmopressin (Minirin)-infusjon.