Integration of behavioral and neurophysiological approaches in neurotoxicology.
The validity of behavioral and neurophysiological models can only be assessed with respect to the type of the modelled effect: for acute changes in activation level as well as for chronic motor or sensory deficits both approaches are equally prone to misinterpretation. Validation of behavioral criteria supported by neurophysiological correlates and vice versa is the best protection. In the cognitive and emotional sphere, a shift to testing of the readiness ("fluidity") dimension seems to be promising both in human and animal studies, permitting also more reliable extrapolations and efficient cooperation of behavioral and neurophysiological approaches.
Frantík
E
E
National Institute of Public Health, Centre of Industrial Hygiene and Occupational Diseases, Prague, Czechoslovakia.
Horváth
M
M
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D006801:Humans; D009043:Motor Activity / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects*; D009424:Nervous System Physiological Phenomena; D014116:Toxicology / Q000379:methods*