Methanol poisoning.
Methanol ingestion is an uncommon form of poisoning that can cause severe metabolic disturbances, blindness, permanent neurologic dysfunction and death. While methanol itself may be harmless, it is converted in vivo to the highly toxic formic acid. The diagnosis is sometimes elusive and requires a high index of suspicion. Because antidotal treatment is available it is important to recognize methanol poisoning promptly. The presence of metabolic acidosis associated with an increased anion gap and increased osmol gap are important laboratory findings. Specific therapeutic measures include correction of the metabolic acidosis with sodium bicarbonate and administration of enteral or parenteral ethanol to competitively inhibit the metabolic breakdown of methanol to formic acid. Hemodialysis accelerates the elimination of both methanol and formic acid and also assists in correction of the metabolic acidosis. Experimental data suggests that administration of folic acid may be of benefit by hastening the metabolism of formic acid to carbon dioxide. Prompt institution of specific therapy can probably decrease the morbidity and mortality associated with this form of poisoning.
Kruse
J A
JA
Division of Critical Care Medicine, Wayne State University School of Medicine, Detroit Receiving Hospital, Michigan.
D000136:Acid-Base Equilibrium; D000140:Acidosis, Lactic / Q000097:blood / Q000209:etiology / Q000378:metabolism; D000818:Animals; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use; D005561:Formates / Q000097:blood; D005751:Gastric Lavage; D000882:Haplorhini; D006801:Humans; D000432:Methanol / Q000378:metabolism / Q000506:poisoning*; D009994:Osmolar Concentration; D011041:Poisoning / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D011379:Prognosis
D005561:Formates; C030544:formic acid; D000431:Ethanol; D000432:Methanol