Matlystatins, new inhibitors of typeIV collagenases from Actinomadura atramentaria. I. Taxonomy, fermentation, isolation, and physico-chemical properties of matlystatin-group compounds.
During the course of a screening for inhibitors of typeIV collagenases, new metabolites, designated matlystatins, have been isolated from an actinomycete strain, which was identified as a strain of Actinomadura atramentaria. Matlystatins were composed of five congeners, which were separated and purified by n-butanol extraction and chromatography.
Ogita
T
T
Fermentation Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
Sato
A
A
Enokita
R
R
Suzuki
K
K
Ishii
M
M
Negishi
T
T
Okazaki
T
T
Tamaki
K
K
Tanzawa
K
K
D000111:Acetylcysteine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification; D000192:Actinomycetales / Q000145:classification / Q000166:cytology / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification*; D002845:Chromatography; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D020780:Matrix Metalloproteinase 9; D061965:Matrix Metalloproteinase Inhibitors; D015394:Molecular Structure; D011724:Pyridazines / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification; D016339:Spectrometry, Mass, Fast Atom Bombardment
D000900:Anti-Bacterial Agents; D061965:Matrix Metalloproteinase Inhibitors; D011724:Pyridazines; C078837:matlystatin A; C078839:matlystatin D; C078840:matlystatin E; C078841:matlystatin F; C078838:matlystatin B; D020780:Matrix Metalloproteinase 9; D000111:Acetylcysteine