Effects of topically applied sulphur mustard on tissue glycogen, blood glucose, lactate and pyruvate in mice.
Bis-2-Chloroethyl sulphide, commonly known as sulphur mustard (SM) or mustard gas, an alkylating agent, is frequently used as a chemical warfare agent. Inhibition of glycolysis has been related to skin injury and cell death. The effects of SM on tissue glycogen, blood glucose, lactate/pyruvate ratio were investigated in the present study. After a single dermal application of 1.0 LD50 SM in mice, a significant hyperglycemia was observed at 24 hr post exposure. There was a corresponding decrease in liver glycogen content, with no alteration in glycogen content of brain, muscles and kidney. Blood pyruvate and lactate levels were not appreciably altered.
Sugendran
K
K
Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior.
Jeevaratnam
K
K
Husain
K
K
Singh
R
R
Srivastava
D K
DK
D000287:Administration, Topical; D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D001923:Brain Chemistry / Q000187:drug effects; D006003:Glycogen / Q000032:analysis*; D007773:Lactates / Q000097:blood*; D019344:Lactic Acid; D008099:Liver / Q000737:chemistry / Q000187:drug effects; D008297:Male; D051379:Mice; D009132:Muscles / Q000737:chemistry / Q000187:drug effects; D009151:Mustard Gas / Q000008:administration & dosage / Q000494:pharmacology*; D011773:Pyruvates / Q000097:blood*; D019289:Pyruvic Acid
D001786:Blood Glucose; D007773:Lactates; D011773:Pyruvates; D019344:Lactic Acid; D019289:Pyruvic Acid; D006003:Glycogen; D009151:Mustard Gas