The superfamily of UvrA-related ATPases includes three more subunits of putative ATP-dependent nucleases.
It is demonstrated that the amino acid sequences of the products of E. coli genes sbcC and prrC, and bacteriophage P2 gene old encompass the four conserved motifs typical of the superfamily of UvrA-related ATPases. A more pronounced statistically significant similarity was revealed between SbcC protein, bacteriophage T4 endonuclease component gp46 and bacteriophage T5 protein D13. It is suggested that the newly identified members of the superfamily might all be ATPase components of the respective nucleases, and that the reactions catalyzed by these enzymes are probably ATP dependent.
Koonin
E V
EV
Institute of Microbiology, Academy of Sciences, Moscow, Russian Federation.
Gorbalenya
A E
AE
D000251:Adenosine Triphosphatases / Q000235:genetics*; D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics*; D003090:Coliphages / Q000201:enzymology / Q000235:genetics; D017124:Conserved Sequence; D004268:DNA-Binding Proteins / Q000235:genetics*; D003851:Deoxyribonucleases; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics; D029968:Escherichia coli Proteins; D043211:Exodeoxyribonuclease V; D005090:Exodeoxyribonucleases / Q000235:genetics*; D005092:Exonucleases; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics*; D011487:Protein Conformation; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014764:Viral Proteins / Q000235:genetics
D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; C079414:Old protein, Enterobacteria phage P2; C061563:SbcC protein, Bacteria; C489229:SbcC protein, E coli; D014764:Viral Proteins; D003851:Deoxyribonucleases; D005090:Exodeoxyribonucleases; D005092:Exonucleases; D043211:Exodeoxyribonuclease V; C068631:UvrA protein, E coli; D000251:Adenosine Triphosphatases