title: The succinate dehydrogenase inhibition test for evaluating biopsy specimens and resected tumors of advanced gastric cancer.
abstract: An in vitro chemosensitivity study of both biopsy specimens and surgically resected tumors of advanced gastric cancer from 12 patients was evaluated using the succinate dehydrogenase inhibition (SDI) test. A decrease in succinate dehydrogenase (SD) activity as an indicator of chemosensitivity was determined using cisplatin (CDDP), etoposide (VP-16), and mitomycin C (MMC). In this study, 29 of a total 36 experiments were evaluable (80.6%) and significant correlations were found in all three of the antitumor drugs (P < 0.03). This finding suggests that the SDI test using biopsy specimens may prove valuable for assessing the preoperative chemosensitivity of advanced gastric cancer.
authors: Second Department of Surgery, School of Medicine, Kanazawa University, Ishikawa, Japan.
authors: H
authors: H
authors: Kimura
authors: Y
authors: Y
authors: Yonemura
authors: S
authors: S
authors: Ohyama
authors: K
authors: K
authors: Tsugawa
authors: K
authors: K
authors: Kinoshita
authors: I
authors: I
authors: Ninomiya
authors: T
authors: T
authors: Kosaka
authors: K
authors: K
authors: Miwa
authors: I
authors: I
authors: Miyazaki
authors: M
authors: M
authors: Tanaka
mesh_terms: D000368:Aged; D001706:Biopsy; D002945:Cisplatin / Q000627:therapeutic use; D004354:Drug Screening Assays, Antitumor; D005047:Etoposide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016685:Mitomycin / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors*
chemical_list: D016685:Mitomycin; D005047:Etoposide; D013385:Succinate Dehydrogenase; D002945:Cisplatin