title: Severe hypoxemia-associated intrapulmonary shunt in a patient with chronic liver disease: improvement after medical treatment.
abstract: A 20-yr-old woman with chronic liver disease and angioimmunoblastic lymphadenopathy presented with marked hypoxemia caused by intrapulmonary shunt. Her respiratory tract showed her to be free of angioimmunoblastic lymphadenopathy manifestations. After 12 months of treatment with cyclophosphamide and corticosteroid, the immunologic disease disappeared. Unexpectedly, hypoxia-associated intrapulmonary shunt was no longer present either. To the best of our knowledge, this is the first case of dramatic improvement, with medical therapy, of severe hypoxemia related to noncirrhotic liver disease. However, the mechanism by which this treatment caused the regression of intrapulmonary shunt is unknown.
authors: Service de Pneumologie et de Réanimation Respiratoire, Hôpital Tenon, Paris, France.
authors: J L
authors: JL
authors: Cadranel
authors: B J
authors: BJ
authors: Milleron
authors: J F
authors: JF
authors: Cadranel
authors: J P
authors: JP
authors: Fermand
authors: P
authors: P
authors: Andrivet
authors: J C
authors: JC
authors: Brouet
authors: S
authors: S
authors: Adnot
authors: G M
authors: GM
authors: Akoun
mesh_terms: D000328:Adult; D001706:Biopsy; D001784:Blood Gas Analysis; D006328:Cardiac Catheterization; D002908:Chronic Disease; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006331:Heart Diseases / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D006965:Hyperplasia; D000860:Hypoxia / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D007119:Immunoblastic Lymphadenopathy / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008107:Liver Diseases / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D003520:Cyclophosphamide; D011241:Prednisone