title: Prognostic value of N-myc oncogene amplification and S-100 protein positivity in children with neuroblastic tumors.
abstract: Data on 43 neuroblastic tumors (30 neuroblastomas and 13 ganglioneuroblastomas) obtained from 22 untreated and 21 pretreated children, were analyzed to determine the correlation between N-myc oncogene amplification and immunohistochemically identified S-100 protein positivity. Sixteen patients in whom the tumor showed significant amplification of N-myc (more than ten copies) died, irrespective of S-100 protein positivity and other conventional factors. Among 27 patients with low amplification of N-myc (less than ten copies), the estimated progression-free survival for those whose tumors had numerous S-100 protein-positive cells (P group), and few or no positive cells (N group) was 75% and 17%, respectively (p < 0.0001). Thus, in addition to N-myc oncogene amplification as a reliable indicator of outcome, S-100 protein positivity should be useful for prediction of prognosis in children with neuroblastic tumors showing low amplification of N-myc. Correlations among these results and other clinical factors are briefly discussed.
authors: Second Department of Pathology, Kyushu University School of Medicine, Fukuoka, Japan.
authors: Y
authors: Y
authors: Hachitanda
authors: A
authors: A
authors: Nakagawara
authors: M
authors: M
authors: Nagoshi
authors: M
authors: M
authors: Tsuneyoshi
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000737:chemistry* / Q000235:genetics / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005729:Ganglioneuroma / Q000737:chemistry / Q000235:genetics / Q000473:pathology; D005784:Gene Amplification; D016259:Genes, myc; D006801:Humans; D007223:Infant; D008297:Male; D008479:Mediastinal Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology; D009447:Neuroblastoma / Q000737:chemistry* / Q000235:genetics / Q000473:pathology; D011379:Prognosis; D012186:Retroperitoneal Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology; D009418:S100 Proteins / Q000032:analysis*
chemical_list: D009418:S100 Proteins