Peripheral blood cell repopulation following high-dose cyclophosphamide.
High-dose cyclophosphamide can be used to obtain haematological stem cells from the peripheral blood. In this paper we analyse the dynamics of appearance of cells with these characteristics, together with the impact of this drug on the immunological system. Cyclophosphamide seems to possess immunomodulating effects even at high doses.
Codacci-Pisanelli
G
G
Third Institute of Internal Medicine, University La Sapienza, Rome, Italy.
Franchi
F
F
Afeltra
A
A
Simone
F
F
Bonomo
L
L
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000097:blood / Q000188:drug therapy / Q000276:immunology; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007107:Immune System / Q000187:drug effects; D008558:Melphalan / Q000008:administration & dosage; D008875:Middle Aged
D003520:Cyclophosphamide; D008558:Melphalan