Biosynthesis of benastatin A.
The biosynthesis of benastatin A, produced by Streptomyces sp. MI384-DF12, has been studied by feeding experiments with 14C- and 13C-labeled compounds followed by measurement of radioactivity and 13C NMR analysis. The results indicate that benastatin A is derived from two methionine units and fourteen acetate units, condensed in the "head-to-tail" fashion of typical polyketide biosynthesis.
Aoyama
T
T
Institute of Microbial Chemistry, Tokyo, Japan.
Naganawa
H
H
Muraoka
Y
Y
Aoyagi
T
T
Takeuchi
T
T
D001551:Benz(a)Anthracenes / Q000737:chemistry / Q000378:metabolism*; D002247:Carbon Isotopes; D002250:Carbon Radioisotopes; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D015394:Molecular Structure; D009279:Naphthacenes; D013302:Streptomyces / Q000378:metabolism*
D001551:Benz(a)Anthracenes; D002247:Carbon Isotopes; D002250:Carbon Radioisotopes; D009279:Naphthacenes; C077629:benastatin A