The effects of the serotonin1A receptor agonist buspirone on the blood glucose and pancreatic hormones in rats.
The effects of the serotonin1A (5-HT1A) receptor agonist buspirone on the plasma glucose and pancreatic hormones insulin and glucagon were investigated in rats. Buspirone elicited significant hyperglycemia and hyperglucagonemia, although it did not affect the insulin levels. Adrenodemedullation inhibited both the increase in blood glucose and glucagon levels. These results indicate that buspirone-induced hyperglycemia and hyperglucagonemia are mediated by adrenaline release from the adrenal gland.
Sugimoto
Y
Y
Department of Pharmacology, Kobe Women's College of Pharmacy, Japan.
Yamada
J
J
Kimura
I
I
Watanabe
Y
Y
Horisaka
K
K
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism; D000313:Adrenal Medulla / Q000502:physiology; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002065:Buspirone / Q000494:pharmacology*; D004837:Epinephrine / Q000378:metabolism; D005934:Glucagon / Q000097:blood; D007328:Insulin / Q000097:blood; D008297:Male; D010187:Pancreatic Hormones / Q000097:blood*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
D001786:Blood Glucose; D007328:Insulin; D010187:Pancreatic Hormones; D017366:Serotonin Receptor Agonists; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D005934:Glucagon; D002065:Buspirone; D004837:Epinephrine