title: Protection by chlorpromazine against lethality and renal toxicity of cisplatin in mice.
abstract: The effect of chlorpromazine on acute lethal toxicity and nephrotoxicity induced by cisplatin was studied in mice. Chlorpromazine given (i.p.) 1 h before cisplatin greatly reduced lethal and renal toxicities of cisplatin. Chlorpromazine did not reduce the antitumor activity of cisplatin against Sarcoma 180 in ddY mice or EL-4 Leukemia in C57BL/6J mice.
authors: Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
authors: M
authors: M
authors: Ishikawa
authors: M
authors: M
authors: Ozaki
authors: Y
authors: Y
authors: Takayanagi
authors: K
authors: K
authors: Sasaki
mesh_terms: D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology*; D002945:Cisplatin / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects*; D007942:Leukemia, Experimental / Q000188:drug therapy; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D012510:Sarcoma 180 / Q000188:drug therapy
chemical_list: D002945:Cisplatin; D002746:Chlorpromazine