Renal failure in temporal arteritis.
We report a case of biopsy-proven temporal arteritis and polymyalgia rheumatica with improved clinical symptoms with steroid treatment but with subsequent renal failure while on steroids. Kidney biopsy showed focal segmental necrotizing glomerulonephritis with crescents and small-vessel vasculitis. Treatment with methylprednisolone and cyclophosphamide achieved normalization of renal function. We emphasize the importance of kidney biopsy because of its therapeutic implications. The previous literature concerning renal disease in temporal arteritis is discussed.
Canton
C G
CG
Department of Nephrology, Hospital de la Princesa, Universidad Autonoma de Madrid, Spain.
Bernis
C
C
Paraiso
V
V
Barril
G
G
García
A
A
Osorio
C
C
Rincón
B
B
Traver
J A
JA
D000368:Aged; D001706:Biopsy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D013700:Giant Cell Arteritis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology; D008775:Methylprednisolone / Q000008:administration & dosage; D011111:Polymyalgia Rheumatica / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D011241:Prednisone / Q000008:administration & dosage; D051437:Renal Insufficiency / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D013699:Temporal Arteries / Q000473:pathology
D003520:Cyclophosphamide; D011241:Prednisone; D008775:Methylprednisolone