title: The potassium channel gene HK1 maps to human chromosome 11p14.1, close to the FSHB gene.
abstract: Transiently activating (A-type) potassium (K) channels are important regulators of action potential and action potential firing frequencies. HK1 designates the first human cDNA that is highly homologous to the rat RCK4 cDNA that codes for an A-type K-channel. The HK1 channel is expressed in heart. By somatic cell hybrid analysis, the HK1 gene has been assigned to human chromosome 11p13-p14, the WAGR deletion region (Wilms tumor, aniridia, genito-urinary abnormalities and mental retardation). Subsequent pulsed field gel (PFG) analysis and comparison with the well-established PFG map of this region localized the gene to 11p14,200-600 kb telomeric to the FSHB gene.
authors: Institut für Humangenetik, Philipps Universität, Marburg, Federal Republic of Germany.
authors: M
authors: M
authors: Gessler
authors: A
authors: A
authors: Grupe
authors: K H
authors: KH
authors: Grzeschik
authors: O
authors: O
authors: Pongs
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D006224:Cricetinae; D015342:DNA Probes; D004277:DNA, Single-Stranded; D006801:Humans; D006822:Hybrid Cells; D015221:Potassium Channels / Q000235:genetics*
chemical_list: D015342:DNA Probes; D004277:DNA, Single-Stranded; D015221:Potassium Channels