The destruction of virulent Entamoeba histolytica by activated human eosinophils.
Unlike normal (i.e., non-activated) human eosinophils that are unable to destroy virulent Entamoeba histolytica even in the presence of antibodies and complement, activated eosinophils effectively destroy the parasite in vitro without the help of opsonins, yet increase this capacity with their assistance. Many activated eosinophils succumb in the process as well, probably victims of toxic products released by dying amoebae. Human activated eosinophils thus behave more like activated macrophages than like neutrophil polymorphonuclear leucocytes that are notoriously incompetent in dealing with virulent amoebae. As a regular constituent of early inflammatory reactions, and notwithstanding the absence of blood and tissue eosinophilia in invasive amoebiasis, the activated eosinophil may play a role in the defence against E. histolytica.
López-Osuna
M
M
Division of Immunology, Faculty of Medicine, Universidad Nacional Autonoma de Mexico, Mexico City.
Arellano
J
J
Kretschmer
R R
RR
D000328:Adult; D000818:Animals; D003602:Cytotoxicity, Immunologic; D004748:Entamoeba histolytica / Q000276:immunology* / Q000472:pathogenicity; D004804:Eosinophils / Q000187:drug effects / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D008163:Luminescent Measurements; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D014774:Virulence
D009240:N-Formylmethionine Leucyl-Phenylalanine