The effect of hypotonicity on the mean platelet volume of patients with thrombo-embolism.
When dipotassium EDTA anticoagulated platelet rich plasma was incubated against a range of hypotonic saline concentrations, platelet volume was seen to change in a particular and reproducible fashion. When platelets taken from patients suffering a thromboembolic episode were tested in the same manner, a different pattern of response was observed the platelets being far less tolerant to osmotic stress. Similar changes occurred in platelets from ante-natal subjects. Platelets from both groups regained their tolerance to hypotonicity following either the thromboembolic incident or parturition respectively.
Davis
W P
WP
Department of Haematology, Eastbourne District General Hospital.
Graham
P
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects* / Q000648:ultrastructure; D002462:Cell Membrane / Q000648:ultrastructure; D048429:Cell Size / Q000187:drug effects; D002951:Citrates / Q000494:pharmacology; D019343:Citric Acid; D004492:Edetic Acid / Q000494:pharmacology; D005260:Female; D006801:Humans; D007038:Hypotonic Solutions / Q000494:pharmacology*; D008297:Male; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood; D009996:Osmotic Fragility; D049590:Postpartum Period / Q000097:blood; D011247:Pregnancy / Q000097:blood; D015203:Reproducibility of Results; D012965:Sodium Chloride / Q000494:pharmacology; D013923:Thromboembolism / Q000097:blood*
D000925:Anticoagulants; D002951:Citrates; D007038:Hypotonic Solutions; D019343:Citric Acid; D012965:Sodium Chloride; D004492:Edetic Acid