Rapid emergence of quinolone resistance in Campylobacter jejuni in patients treated with norfloxacin.
15/60 subjects from one center, who all took part in a multicenter double-blind, placebo-controlled study to evaluate the effect of norfloxacin on acute enteritis, had norfloxacin sensitive strains of Campylobacter jejuni in pre-study stool specimens. Eight of the 15 subjects received active drug. In 3 of these 8, high-level quinolone resistant Campylobacter strains of the same serotype as in pre-treatment samples were isolated 4-90 days after the initiation of treatment.
Wretlind
B
B
Department of Clinical Bacteriology, Danderyd Hospital, Sweden.
Strömberg
A
A
Ostlund
L
L
Sjögren
E
E
Kaijser
B
B
D000328:Adult; D002169:Campylobacter Infections / Q000188:drug therapy*; D016123:Campylobacter jejuni / Q000187:drug effects*; D004311:Double-Blind Method; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009643:Norfloxacin / Q000008:administration & dosage*
D009643:Norfloxacin