A121--an antifungal compound from Streptomyces species.
A non-polyene antifungal antibiotic, A121, produced by an unidentified strain of Streptomyces species was isolated and purified to homogeneity. This antibiotic was found to be active against a number of filamentous fungi including some plant and human pathogens. On the basis of its infrared spectrum, proton magnetic resonance, mass spectra, and some chemical derivatives, a plausible chemical constitution of this antibiotic is proposed. Its antibiotic activity apparently requires the presence of an alpha-ketol system in the molecule.
Singh
S
S
Department of Chemistry, Pennsylvania State University, Hazleton 18201.
Samanta
T B
TB
D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013055:Spectrophotometry, Infrared; D013302:Streptomyces / Q000737:chemistry* / Q000145:classification
D000935:Antifungal Agents; D005663:Furans; C079079:A 121