A narrow window of intracellular calcium concentration is optimal for neurite outgrowth in rat sensory neurones.
We have examined neurite outgrowth in rat sensory neurones when cytosolic free calcium concentration ([Ca2+]i) was varied in the range 0-60 nM. Neurite outgrowth was maximal at 35 nM [Ca2+]i and was reduced at higher and lower values of [Ca2+]i. These results provide direct evidence for Mattson and Kater's suggestion of an optimal calcium range for growth cone function.
al-Mohanna
F A
FA
Department of Physiology, University College London, UK.
Cave
J
J
Bolsover
S R
SR
D000818:Animals; D002118:Calcium / Q000502:physiology*; D002465:Cell Movement; D004533:Egtazic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D005727:Ganglia, Spinal / Q000502:physiology; D007424:Intracellular Fluid / Q000502:physiology; D016501:Neurites / Q000502:physiology*; D009475:Neurons, Afferent / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D004533:Egtazic Acid; C025603:1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid; D002118:Calcium