[Cyclosporin in a bioadhesive formulation in the therapy of oral erosive lichen planus. A clinico-experimental evaluation].
This study illustrates the possible topical therapy of OLP with cyclosporine A under bioadhesive gel formula. The treatment was carried out on 6 patients for 8 weeks in much lower (48 mg/day) than those used by other authors. The novelty of this study lies in the use of a bioadhesive formula with carbosymethylcellulose which allows CsA to remain on oral mucosa for about two hours. The remarkable results have shown a reduction ranging from 50 to 80% of oral lesions, thus proposing its specific use in all the forms resisting usual therapy.
Gombos
F
F
Istituto di Clinica Odontoiatrica e Stomatologica, Università degli Studi di Napoli Federico II.
Cappello
B
B
Gaeta
G M
GM
La Rotonda
M I
MI
Serpico
R
R
Miro
A
A
D000287:Administration, Topical; D000328:Adult; D016572:Cyclosporine / Q000008:administration & dosage* / Q000009:adverse effects; D004341:Drug Evaluation; D006801:Humans; D008010:Lichen Planus / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D009059:Mouth Diseases / Q000188:drug therapy* / Q000473:pathology; D009061:Mouth Mucosa / Q000187:drug effects / Q000473:pathology; D009824:Ointments
D009824:Ointments; D016572:Cyclosporine
La ciclosporina in formulazione bioadesiva nella terapia del Lichen planus orale erosivo. Valutazione clinico-sperimentale.