Effect of recipient gender and race on heart and kidney allograft survival.
Study of long-term survival of heart allografts shows that AA males and females have lower graft survival rates than those observed in NAC recipients. Primary kidney allografts in AA males, but not females, also display lower 5-year survival rates compared to those observed in the corresponding populations of NAC. Comparison of graft survival in the overall population of male and female recipients of kidney allografts shows that females have higher graft survival rates, probably as a result of better HLA matching. The level of alloantibody activity in posttransplantation sera is similar in the two populations, suggesting that factors other than HLA mismatching may contribute to the higher degree of graft failure in AA recipients.
Reed
E
E
Department of Pathology, College of Physicians & Surgeons, Columbia University, New York, New York 10032.
Cohen
D J
DJ
Barr
M L
ML
Ho
E
E
Reemtsma
K
K
Rose
E A
EA
Hardy
M
M
Suciu-Foca
N
N
D000206:Actuarial Analysis; D000367:Age Factors; D044383:Black People; D002102:Cadaver; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000276:immunology* / Q000401:mortality; D006085:Graft Survival / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology; D016027:Heart Transplantation / Q000276:immunology* / Q000401:mortality; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology* / Q000401:mortality; D011183:Postoperative Complications / Q000276:immunology* / Q000401:mortality; D012737:Sex Factors; D015996:Survival Rate; D044465:White People
D006680:HLA Antigens