Evaluation of the effects of total sleep deprivation on cerebral blood flow using single photon emission computerized tomography.
HMPAO-single photon emission computerized tomography (SPECT) is a useful technique in studying cerebral blood flow (CBF). This method is suitable to evaluate the differences of CBF with reference to total sleep deprivation (TSD) within 24 h because of the short half-life of the radiopharmaceutical compound. In the present study, CBF before and after TSD was analysed in patients suffering from major depression. The morning before and after TSD, Tc-HMPAO-SPECT was performed in 20 patients. Hamilton Rating Scale for Depression scores and subjective ratings were obtained daily. Eleven patients responded to TSD; 9 were nonresponders. The main finding was a significant left temporal and mainly right parietal increase of CBF, which was observed in the responders only. CBF values and the severity of depression correlated inversely.
Volk
S
S
Department of Psychiatry II, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
Kaendler
S H
SH
Weber
R
R
Georgi
K
K
Maul
F
F
Hertel
A
A
Pflug
B
B
Hör
G
G
D000328:Adult; D000368:Aged; D001921:Brain / Q000098:blood supply*; D002531:Cerebellum / Q000098:blood supply; D002540:Cerebral Cortex / Q000098:blood supply; D003866:Depressive Disorder / Q000000981:diagnostic imaging / Q000523:psychology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010555:Personality Inventory; D012016:Reference Values; D012039:Regional Blood Flow / Q000502:physiology; D012892:Sleep Deprivation / Q000502:physiology*; D015899:Tomography, Emission-Computed, Single-Photon