Inhibition of glandular and plasma kallikrein by benzamidine derivatives.
Besides guanidino compounds and amines structurally related to arginine and lysine, compounds with other cationic groups are inhibitors of trypsin-like serine proteinases. Particularly aromatic ring structures with an amidino moiety have high affinity for these enzymes. In most cases ordinary benzamidine derivatives are no selective inhibitors, however, among derivatives of N alpha-arylsulfonyl-omega-amidinophenyl-alpha-amino-alkylcarboxylic acids selective competitive inhibitors of several enzymes were found. Amides of phenyl-alpha-aminobutyric acid containing an amidino moiety are inhibitors of plasma kallikrein. The p-amidinoanilide of 2-tosylamino-4-phenylbutyric acid inhibits selectively plasma kallikrein with a Ki of 0.70 mumol/l. In contrast, potent and selective inhibitors of glandular kallikrein were hardly found among benzamidines.
Stürzebecher
J
J
Institute of Pharmacology & Toxicology, Medical Academy Erfurt, FRG.
Vieweg
H
H
Prasa
D
D
D000818:Animals; D001550:Benzamidines / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007610:Kallikreins / Q000037:antagonists & inhibitors* / Q000302:isolation & purification; D007700:Kinetics; D015394:Molecular Structure; D010179:Pancreas / Q000201:enzymology; D013329:Structure-Activity Relationship; D013552:Swine
D001550:Benzamidines; D007610:Kallikreins