On-line high-performance liquid chromatographic/gas chromatographic/tandem ion trap mass spectrometric determination of levamisole in milk.
On-line high-performance liquid chromatography/high-resolution gas chromatography/tandem mass spectrometry, performed on a quadrupole ion trap, has been used as a rapid method for the quantification of the anthelmintic drug levamisole in raw milk extracts following a simple extraction procedure. Detection at the 0.5 p.p.b. level and a linear response in the 10-0.5 p.p.b. range is demonstrated. Multiple-scan monitoring techniques have been used to acquire chemical ionization tandem mass spectra and electron impact mass spectra in a single chromatographic run.
Chappell
C G
CG
School of Chemical Sciences, University of East Anglia, Norwich, UK.
Creaser
C S
CS
Stygall
J W
JW
Shepherd
M J
MJ
D000818:Animals; D000871:Anthelmintics / Q000032:analysis*; D004350:Drug Residues / Q000032:analysis*; D005506:Food Contamination / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D007978:Levamisole / Q000032:analysis*; D008452:Maximum Allowable Concentration; D008892:Milk / Q000737:chemistry*
D000871:Anthelmintics; D007978:Levamisole