Water-in-oil emollients as steroid-sparing adjunctive therapy in the treatment of psoriasis.
An open label study of ninety-six patients with chronic plaque-type psoriasis demonstrated the efficacy of the addition of water-in-oil emollients to a topical corticosteroid regimen. Twice daily application of betamethasone dipropionate cream and once daily application of both betamethasone dipropionate cream and either a water-in-oil based moisturizing cream or lotion were equivalent in efficacy (p = 0.05). Once daily application of both betamethasone dipropionate cream and either a water-in-oil based cream or lotion was significantly better than once daily application of betamethasone dipropionate cream alone (p = 0.05). Water-in-oil emollients are useful in the therapy of chronic, plaque-type psoriasis and provide a steroid-sparing effect.
Watsky
K L
KL
Yale University School of Medicine, Department of Dermatology, New Haven, Connecticut 06519.
Freije
L
L
Leneveu
M C
MC
Wenck
H A
HA
Leffell
D J
DJ
D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001623:Betamethasone / Q000008:administration & dosage*; D002908:Chronic Disease; D004643:Emollients / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009821:Oils; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology; D014867:Water
D004643:Emollients; D009821:Oils; D014867:Water; D001623:Betamethasone