[Comparative efficacy of annual and semi-annual doses of ivermectin or diethylcarbamazine for the prevention of lymphatic filariasis].
A double blind randomized trial was performed on 58 healthy Polynesian Wuchereria bancrofti carriers, they were randomly allocated to treatments with repeated annual or semi-annual doses of ivermectin 100 mcg/kg or diethylcarbamazine (DEC) 3 mg/kg, or with repeated annual doses of DEC 6 mg/kg. After the 12-month treatment, the clearance of microfilaremia was complete in 7 of the 23 carriers treated with ivermectin and in 3 of the 35 treated with DEC. Nine months after that treatment, the lowest mean microfilaremia was observed in the carriers treated with 3 successive semi-annual doses of DEC 3 mg/kg. Adverse reactions were comparable in carriers treated with ivermectin and in those treated with DEC, and did not interfere with daily activities of treated subjects.
Cartel
J L
JL
Institut Territorial de Recherches Médicales Louis Malardé, Tahiti, Polynésie Française.
Spiegel
A
A
Nguyen
L
L
Moulia-Pelat
J P
JP
Martin
P M
PM
Roux
J F
JF
D000293:Adolescent; D000328:Adult; D000818:Animals; D004049:Diethylcarbamazine / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004604:Elephantiasis / Q000188:drug therapy*; D006801:Humans; D007559:Ivermectin / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D014958:Wuchereria bancrofti
D007559:Ivermectin; D004049:Diethylcarbamazine
Efficacité comparée de doses annuelles et semestrielles d'ivermectine ou de diethylcarbamazine pour la prévention de la filariose lymphatique.