[Effect of a new prostaglandin aroxaprostol on the contractile activity of the uterus and its abortive action in experimental studies].
Experiments with pregnant and nonpregnant rats have shown that aroxaprostol, a group F2 alpha prostaglandin, injected intravenously and intramuscularly in a dose of 50 micrograms/kg, stimulates the uterine bioelectric activity, increasing both the amplitude and frequency of biopotentials, this evidencing intensification of its contractility. Aroxaprostol has shown an abortive effect, that was related to the luteolytic effect of the drug, manifesting by reduction of progesterone level in the ovaries.
Korkhov
V V
VV
Mats
M N
MN
Pankrashkina
N P
NP
Stepanov
M G
MG
Khristoforov
V L
VL
D000019:Abortifacient Agents / Q000008:administration & dosage* / Q000494:pharmacology; D000028:Abortion, Induced / Q000379:methods*; D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D005260:Female; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008954:Models, Biological; D011247:Pregnancy; D011453:Prostaglandins / Q000008:administration & dosage* / Q000494:pharmacology; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013268:Stimulation, Chemical; D013997:Time Factors; D014590:Uterine Contraction / Q000187:drug effects* / Q000502:physiology
D000019:Abortifacient Agents; D011453:Prostaglandins; D011461:Prostaglandins F, Synthetic; C078994:aroxaprostol
Vliianie novogo prostaglandina aroksaprostola na sokratitel'nuiu aktivnost' matki i ego abortivnyĭ éffekt v éksperimente.