title: Severity of chronic metabolic acidosis and growth of rats with chronic uremia.
abstract: To determine what levels of chronic metabolic acidosis affect growth in uremia, we compared two groups of uremic rats receiving a 30% protein diet. This diet induced acidosis in A rats (n = 52; pH: 6.9-7.35) which was prevented by the addition of NaHCO3 in the diet of B rats (n = 52; pH: 7.38-7.46). A rats were separated into five groups by increasing severity of acidosis and were matched with B rats of similar renal function. Comparison between A and B rats showed: (1) no difference in food intake; (2) a reduction of weight gain only for severe acidosis with pH around 7.20 or less; (3) a reduction of length gain which was observed for less severe acidosis than reduction of weight gain, but which did not exist for marginal acidosis (pH > 7.25).
authors: INSERM U-192, Hôpital Necker-Enfants Malades, Paris, France.
authors: S
authors: S
authors: Maniar
authors: A
authors: A
authors: Caldas
authors: D
authors: D
authors: Laouari
authors: C
authors: C
authors: Kleinknecht
mesh_terms: D000138:Acidosis / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D000818:Animals; D001827:Body Height / Q000502:physiology*; D001835:Body Weight / Q000502:physiology*; D002908:Chronic Disease; D004044:Dietary Proteins / Q000008:administration & dosage; D004435:Eating / Q000502:physiology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014511:Uremia / Q000097:blood / Q000150:complications / Q000503:physiopathology*
chemical_list: D004044:Dietary Proteins