Pathology induced by interleukin-6.
Interleukin 6 (IL-6) is a multi-functional cytokine which plays an important role in the immune response, hemopoiesis and host defense. Recombinant human IL-6 (rhIL-6) was administered at high doses to mice, rats and non-human primates. In all species IL-6 had an immunostimulatory and hemopoietic (especially on megakaryocytes) effect. An acute phase response was most pronounced in non-human primates, which was not, however, associated with any major histopathological liver change. Finally, no evidence of glomerular pathology was found. Neutralising antibodies were detected within 10 days of rhIL-6 administration in all species.
Ryffel
B
B
University of Zurich, Institute of Toxicology, Schwerzenbach-Zurich, Switzerland.
Kammüller
M
M
Robison
R
R
Myers
L
L
D000818:Animals; D001773:Blood Cells / Q000187:drug effects; D005260:Female; D015850:Interleukin-6 / Q000633:toxicity*; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008297:Male; D051379:Mice; D051381:Rats; D011994:Recombinant Proteins / Q000633:toxicity
D015850:Interleukin-6; D011994:Recombinant Proteins