[The effect of a single dose of Bisoprolol on changes in blood pressure and hemodynamic indicators in patients with mild hypertension].
The authors administered to 10 patients with mild hypertension a single dose of 10 mg bisoprolol (Concor-Merck) during bioimpedance control of changes of the cardiac index and peripheral vascular resistance after an interval of 3 and 24 hours following administration of the drug. In all patients administration of the drug led to a statistically significant drop of the blood pressure. In patients with a high cardiac output (group A, n = 6) the decline of blood pressure was due to a blocked increment of the cardiac output and a slight block of the peripheral vascular resistance. In the group with a low cardiac output and high peripheral vascular resistance (group B, n = 3) the drop of the blood pressure was caused by peripheral vascular dilatation, the cardiac output was influenced minimally. Bisoprolol did not affect the left ventricular systolic function.
Oral
I
I
I. interní klinika FN Olomouc.
Vareka
I
I
Marek
D
D
D017298:Bisoprolol / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008875:Middle Aged
D017298:Bisoprolol
Vliv jednorázového podání Bisoprololu na zmĕnu krevního tlaku a hemodynamických ukazatelu u nemocných s mírnou hypertenzi.