[Intravenous infusion of volatile fatty acids as a metabolic loading test for the evaluation of the possible effects of butafosfane on the energy metabolism of cattle].
In 10 German Black and White heifers metabolic stress reactions were induced by intravenous infusion of propionate and butyrate to demonstrate possible effects of prior medication with butafosfane. This investigation included a preliminary feeding period, followed by 18 hours of feed withdrawal, premedication with butafosfane or placebo and infusion of volatile fatty acids. Reactions were assessed by monitoring biochemical and clinical parameters. A total of 19 blood samples per series were taken in which the concentrations of glucose, free fatty acids, volatile fatty acids, beta-hydroxybutyrate, cortisol and insulin were measured. Clinical parameters recorded included heart rate and respiratory rate. During loading with propionate effects of butafosfane on plasma levels of cortisol and insulin could be demonstrated. The differences noted in the other parameters were only insignificant. The loading test chosen is suitable for the demonstration of effects of butafosfane on metabolic parameters which could hardly be influenced by this substance in unstressed animals.
Hänsel
A
A
Institut für Physiologische Chemie Tierärztlichen Hochschule, Hannover.
Fuhrmann
H
H
Sallmann
H P
HP
Klee
W
W
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002417:Cattle / Q000378:metabolism*; D004734:Energy Metabolism / Q000187:drug effects*; D005232:Fatty Acids, Volatile / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D006854:Hydrocortisone / Q000097:blood; D007262:Infusions, Intravenous / Q000662:veterinary; D007328:Insulin / Q000097:blood; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000008:administration & dosage / Q000494:pharmacology*
D001786:Blood Glucose; D005232:Fatty Acids, Volatile; D007328:Insulin; D063065:Organophosphonates; D009943:Organophosphorus Compounds; C030504:butaphosphone; D006854:Hydrocortisone
Intravenöse Infusion flüchtiger Fettsäuren als Stoffwechselbelastungstest zur Uberprüfung möglicher Butafosfanwirkungen auf den Energiestoffwechsel des Rindes.