Central action of sigma receptor ligand, JO 1784, to suppress CRF-induced inhibition of gastric function in conscious rats.
The central interaction between the sigma receptor ligand, JO 1784, and corticotropin-releasing factor (CRF)-induced inhibition of gastric acid secretion and emptying was investigated in conscious rats. Intracisternal (i.c.) injection of CRF (5 micrograms) inhibited by 95% gastric acid secretion. JO 1784 (0.05-0.5 micrograms) given i.c. immediately before i.c. injection of CRF partially reversed CRF antisecretory action whereas JO 1784 (5 micrograms) given i.v. had no effect. CRF (0.6 micrograms i.c.)-induced 83% inhibition of gastric emptying was reversed by 45% by JO 1784 (5 micrograms i.c.). JO 1784 (5-50 micrograms i.c.) did not influence basal gastric function. These data demonstrate a centrally mediated antagonistic action of the sigma receptor ligand, JO 1784, on i.c. CRF-induced inhibition of gastric function.
Yoneda
M
M
Veterans Administration Medical Center, Department of Medicine and Brain Research Institute, UCLA 90073.
Junien
J L
JL
Taché
Y
Y
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002934:Cinnamates / Q000378:metabolism / Q000494:pharmacology*; D003346:Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D003521:Cyclopropanes / Q000378:metabolism / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism*; D005746:Gastric Emptying / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D017480:Receptors, sigma / Q000378:metabolism
D002934:Cinnamates; D003521:Cyclopropanes; D017480:Receptors, sigma; D003346:Corticotropin-Releasing Hormone; C065310:igmesine