Residual left ventricular pump function after acute myocardial infarction in NIDDM patients.
OBJECTIVE
Left ventricular remodeling occurs immediately after MI, involving structural changes in noninfarcted segment. However, the residual left ventricular pump function in NIDDM patients after acute MI has not been clarified. The purpose of this study was to evaluate the difference in the process of left ventricular remodeling between NIDDM and nondiabetic patients.


METHODS
Left ventricular regional EF images obtained by radionuclide angiography were investigated in 20 NIDDM and 29 nondiabetic patients the 3rd wk after acute MI.


RESULTS
Regional EF of the noninfarcted area and P/V had a significant hyperbolic relation with left ventricular EDV in both groups of patients. Despite no difference in the extent of myocardial necrosis and the number of coronary vessels diseased between NIDDM and nondiabetic patients, regional EF of the noninfarcted area and P/V were significantly lower when left ventricular EDV increased in NIDDM patients compared with nondiabetic patients.


CONCLUSIONS
Pathogenetic changes of the residual myocardium associated with NIDDM may adversely influence the process of left ventricular remodeling after MI, especially in patients with increased left ventricular EDV.
Iwasaka
T
T
Second Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Takahashi
N
N
Nakamura
S
S
Sugiura
T
T
Tarumi
N
N
Kimura
Y
Y
Okubo
N
N
Taniguchi
H
H
Matsui
Y
Y
Inada
M
M
D000328:Adult; D000368:Aged; D001794:Blood Pressure; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000503:physiopathology*; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000503:physiopathology*; D012044:Regression Analysis; D012907:Smoking; D014280:Triglycerides / Q000097:blood; D016277:Ventricular Function, Left
D014280:Triglycerides; D002784:Cholesterol