A double-blind placebo controlled trial of medroxyprogesterone acetate and cyproterone acetate with seven pedophiles.
Seven of ten pedophiles in hospital completed a double-blind, placebo-controlled two-dose comparison of medroxyprogesterone acetate and cyproterone acetate. Sequential measures during the 28 week study were: patient self-reports, nurses' observations, phallometry, hormone levels and side-effects. The drugs, which performed equivalently, reduced sexual thoughts and fantasies, the frequency of early morning erections on awakening, the frequency and pleasure of masturbation, and level of sexual frustration. Penile responses were also reduced but to a lesser degree and were more variable. Serum testosterone FSH and LH all declined during drug administration, but by the end of the final placebo phase had essentially returned to (or exceeded) pre-drug values. Our experience suggests that only a minority of pedophiles are likely to accept libido-reducing drugs.
Cooper
A J
AJ
St. Thomas Psychiatric Hospital, St. Thomas, Ontario.
Sandhu
S
S
Losztyn
S
S
Cernovsky
Z
Z
D000328:Adult; D017373:Cyproterone Acetate / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007989:Libido / Q000187:drug effects; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage* / Q000009:adverse effects; D010378:Pedophilia / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D010410:Penile Erection / Q000187:drug effects; D011388:Prolactin / Q000097:blood; D012725:Sexual Behavior / Q000187:drug effects; D013739:Testosterone / Q000097:blood
D013739:Testosterone; D017373:Cyproterone Acetate; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D017258:Medroxyprogesterone Acetate