Bayesian estimation of streptomycin pharmacokinetics.
Streptomycin dose requirements were determined in an 83-year-old man with renal impairment who was being treated for miliary tuberculosis. Concentration measurements were interpreted using a Bayesian parameter estimation program. Estimated creatinine clearance (1.1 L/h) was used as a starting value for streptomycin clearance, and volume was initially assumed to be 0.3 L/kg. Bayesian estimates of clearance were close to the starting value and declined from 1.4 L/h to 0.9 L/h during the course of therapy. Volume was higher than the initial estimate (0.4-0.5 L/kg), possibly due to the patient having a low albumin and being underweight. Satisfactory concentrations were maintained for several weeks with doses of 500 mg every 36-48 h.
Thomson
A H
AH
Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland.
Coote
J
J
MacPherson
L
L
Gordon
J
J
D000368:Aged; D000369:Aged, 80 and over; D001499:Bayes Theorem; D006801:Humans; D008297:Male; D013307:Streptomycin / Q000493:pharmacokinetics*; D014391:Tuberculosis, Miliary / Q000188:drug therapy / Q000378:metabolism
D013307:Streptomycin