Disposition kinetics and dosage of cephalexin in cow calves following intramuscular administration.
Cephalexin was administered im to cow calves at a dose rate of 10 mg/kg bw. After im administration, the disposition kinetics of cephalexin followed a 1-compartment open model. The values of elimination half-life, volume of distribution and total body clearance were 2.00 +/- 0.13 h, 0.32 +/- 0.02 l/kg and 1.899 +/- 0.199 ml/kg/min, respectively. 58.8% of cephalexin administered was recovered in the urine within 24 h. A satisfactory intramuscular dosage regimen of cephalexin in cow calves would be 15 mg/kg administered at 9-h intervals.
Garg
S K
SK
Himachal Pradesh Agricultural University, Palampur, India.
Chaudhary
R K
RK
Srivastava
A K
AK
D000042:Absorption; D000818:Animals; D001682:Biological Availability; D002417:Cattle / Q000378:metabolism*; D002506:Cephalexin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D006207:Half-Life; D007273:Injections, Intramuscular / Q000662:veterinary; D014018:Tissue Distribution
D002506:Cephalexin