The perivascular fibrotic reaction in rat brain in the late period after experimental clinical death. I. Capillary vessels.
In this paper we studied the pericapillary zone of the hypothalamic neurosecretory nuclei and temporal cerebral cortex of rats 6-12 months after experimentally evoked cardiac arrest of 10 minutes duration. The most significant ultrastructural findings were presence of single collagen fibrils and collagen bundles in the compartment between endothelia and pericytes, pericytes and basement membrane and also inside the phagocytic cells. In the animals that survived at least 10 months after resuscitation the capillaries filled with thrombocytes were encountered. Moreover, in the vicinity of these capillaries the dead cells and collagen bundles were observed. We interpret these findings as the evidence of the reparatory process in the border between capillaries and the surrounding brain cells. We discuss the hypothesis that the non-fibroblastic cells present in rat brain are able to synthesize collagen that leads to a process comparable with the fibrosis of parenchymal organs.
Walski
M
M
Laboratory of the Ultrastructure of the Nervous System Medical Research Centre, Polish Academy of Sciences, Warsaw.
Celary-Walska
R
R
Borowicz
J
J
D000818:Animals; D001921:Brain / Q000098:blood supply* / Q000473:pathology* / Q000648:ultrastructure; D001926:Brain Death; D002545:Brain Ischemia / Q000473:pathology*; D002196:Capillaries / Q000473:pathology* / Q000648:ultrastructure; D005355:Fibrosis; D006323:Heart Arrest / Q000473:pathology*; D007031:Hypothalamus / Q000098:blood supply / Q000473:pathology / Q000648:ultrastructure; D008854:Microscopy, Electron; D051381:Rats; D017208:Rats, Wistar; D013702:Temporal Lobe / Q000098:blood supply / Q000473:pathology / Q000648:ultrastructure