[Sodium outflow rate through lymphocyte cell membranes, serum levels of sodium, potassium, aldosterone, total catecholamines, 6-keto- PGF2alpha and plasma renin activity in patients with primary arterial hypertension treated with captopril].
Sodium ions outflow rate through lymphocyte membranes, serum sodium, potassium, aldosterone, total catecholamines and 6-keto-PGE alpha levels, and plasma renin activity were studied in patients with mild hypertension associated with low and hugh plasma renin activity treated with captopril in a single dose of 12.3 mg and after the treatment with daily doses of 12.5 mg and 25 mg for 3 days. It was found, that captopril in hypertensive patients with high plasma renin activity decreases both systolic and diastolic blood pressure, decelerates heart rate, and decreases serum total catecholamines and plasma renin activity. Sodium ions outflow rate and serum sodium, potassium, aldosterone, and 6-keto-PGE alpha remain unchanged. Captopril in hypertensive patients with low plasma renin activity. The remaining parameters are unchanged. Moreover, it was noted that serum 6-keto-PGE alpha levels are lower in hypertensive patients with low plasma renin activity.
Mazurek
W
W
Katedry i Kliniki Kardiologii AM we Wrocławiu.
Halawa
B
B
Borejko-Słopecka
G
G
D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002216:Captopril / Q000008:administration & dosage / Q000627:therapeutic use; D002395:Catecholamines / Q000037:antagonists & inhibitors / Q000097:blood*; D002462:Cell Membrane / Q000378:metabolism; D015232:Dinoprostone / Q000031:analogs & derivatives* / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood*; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000097:blood*; D013997:Time Factors; D000092502:Renin Inhibitors
D000450:Aldosterone; D002216:Captopril; D002395:Catecholamines; D015232:Dinoprostone; D011188:Potassium; D012083:Renin; D012964:Sodium; D000092502:Renin Inhibitors
Szybkość wypływu sodu przez błony komórkowe limfocytów, stezenie w surowicy sodu, potasu, aldosteronu, całkowitych amin katecholowych 6-keto-PGF2 alpha oraz aktywność reninowa osocza u chorych na nadciśnienie tetnicze pierwotne leczonych kaptoprylem.