[Successful treatment with combination of methylprednisolone, antilymphocyte globulin and cyclosporine in two cases of aplastic anemia].
Two children with severe and moderate aplastic anemia received combination treatment with methylprednisolone, antilymphocyte globulin and cyclosporine. One child (severe type) was given 2 courses of high dose methylprednisolone during the last 4 weeks without improvement prior to this combination therapy. The other child (moderate type) was not previously treated. Both patients showed complete response within 3 months following this therapy. Serious side effects were not observed. Combination therapy of these three drugs may be beneficial for patients with aplastic anemia.
Ishikawa
Y
Y
Department of Pediatrics, Hokkaido University School of Medicine.
Arioka
H
H
Kobayashi
R
R
Naito
H
H
D000741:Anemia, Aplastic / Q000628:therapy*; D000961:Antilymphocyte Serum / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D016572:Cyclosporine / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007167:Immunotherapy; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D012074:Remission Induction
D000961:Antilymphocyte Serum; D016572:Cyclosporine; D008775:Methylprednisolone