A comparison of the efficacy of two ear drop preparations ('Audax' and 'Earex') in the softening and removal of impacted ear wax.
Thirty-six patients with symptoms of impacted ear wax were recruited to an open, randomized, parallel group study of 'Audax' ear drops and 'Earex' ear drops. Patients had had their symptoms for several weeks and they were assessed on entry for the degree of impaction in each ear. After using the drops, morning and evening for 4 days, they were assessed on the fifth day for degree of impaction, ease of syringing, side-effects or discomfort, and the investigator's and patient's own global impression of efficacy of the ear drops. A trend was seen showing less impaction post-treatment in the 'Audax' group than in the 'Earex' group although the difference did not reach statistical significance. A significant difference was seen in favour of 'Audax' for the frequency and ease of syringing (p < 0.005). No patients in the 'Audax' group reported any side-effect or discomfort although 1 patient using 'Earex' reported slight irritation whilst another found the smell unacceptable. The results of the investigators' and patients' own global impression of efficacy were significantly in favour of 'Audax' ear drops (p < 0.01).
Lyndon
S
S
Medical Department, Napp Laboratories Ltd., Cambridge, England.
Roy
P
P
Grillage
M G
MG
Miller
A J
AJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002571:Cerumen / Q000187:drug effects*; D004338:Drug Combinations; D004424:Ear Canal; D004427:Ear Diseases / Q000188:drug therapy; D005260:Female; D005990:Glycerol; D006018:Glycols / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010938:Plant Oils / Q000627:therapeutic use*; D012459:Salicylates / Q000627:therapeutic use*
D004338:Drug Combinations; D006018:Glycols; D010938:Plant Oils; D012459:Salicylates; C078766:choline salicylate, glycerol drug combination; C047581:earex; D005990:Glycerol