title: Changing pattern of treatment policies invalidates the use of C-reactive protein level and hyponatremia as indicators of sepsis in children with malignancies.
abstract: We evaluated serum C-reactive protein (CRP) level and serum sodium concentration as early indicators of bacteremia in neutropenic children in two different series in 1983-1984 (49 bacteremias) and 1989-1990 (29 bacteremias). During the earlier period, the goal was to avoid unnecessary antimicrobial therapy. Currently a neutropenic patient is placed on antimicrobial therapy at the first sign of fever. In 1983-1984 the serum CRP concentration was elevated in every case, whereas in 1989-1990 it was normal in 34% cases (P = .0001). Hyponatremia was detected on admission in 84% and 52% cases (P = .0001). The urinary sodium concentration was elevated in most cases. The mortality in bacteremia was 22% in 1983-1984 compared to 3% (P = .025) in 1989-1990. Prompt initiation of empirical antimicrobial therapy in children with fever and neutropenia invalidates the use of hyponatremia and an elevated CRP level as early indicators of sepsis.
authors: Children's Hospital, University of Helsinki, Finland.
authors: P
authors: P
authors: Riikonen
authors: U M
authors: UM
authors: Saarinen
authors: M
authors: M
authors: Perkkiö
authors: L
authors: L
authors: Hovi
authors: M A
authors: MA
authors: Siimes
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002096:C-Peptide / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009369:Neoplasms / Q000097:blood / Q000150:complications*; D009503:Neutropenia / Q000097:blood / Q000150:complications*; D012189:Retrospective Studies; D012964:Sodium / Q000097:blood* / Q000652:urine
chemical_list: D000900:Anti-Bacterial Agents; D015415:Biomarkers; D002096:C-Peptide; D012964:Sodium