[The hemostatic system and the status of aortocoronary venous autografts in patients with ischemic heart disease after surgery for direct myocardial revascularization based on autopsy research data].
The study was undertaken to examine the relationship between the major hemostatic factors in the early postoperative period and the status of an autovenous graft in 19 patients with coronary heart disease who died 3 to 40 days after aortocoronary bypass surgery. The hemostatic system was monitored on the patients' admission and during the whole observation. Hypercoagulation was recorded in all patients in the first postoperative hours. A trend towards hypercoagulation during the entire period of observation was more marked in 7 patients whose postmortem study revealed even one nonfunctioning graft than in 12 patients with maintained patency of all grafts. The major parameters associated with graft thrombosis were platelet aggregation, ethanol test, and levels of soluble fibrin monomer components. Platelet aggregation and the presence and degree of soluble fibrin monomer components were of independent correlative significance. The magnitude of degenerative and proliferative changes in the vein was associated with the interval after the surgery. Myocardial infarction in the early postoperative period was related to graft dysfunction.
Knyshov
G V
GV
Furkalo
S N
SN
Ursulenko
V I
VI
Zakharova
V P
VP
Vykhovaniuk
I V
IV
Luk'ianov
Iu N
IuN
Zadorozhnaia
E S
ES
D001011:Aorta / Q000473:pathology* / Q000601:surgery; D001344:Autopsy; D002423:Cause of Death; D003331:Coronary Vessels / Q000473:pathology* / Q000601:surgery; D006083:Graft Occlusion, Vascular / Q000097:blood / Q000401:mortality / Q000473:pathology; D006487:Hemostasis; D006801:Humans; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D009204:Myocardial Revascularization; D014182:Transplantation, Autologous
Sistema gemostaza i sostoianie autovenoznykh aortokoronarnykh transplantatov u bol'nykh ishemicheskoĭ bolezn'iu serdtsa posle operatsii priamoĭ revaskuliarizatsii miokarda po dannym sektsionnykh issledovaniĭ.