title: Synthesis and antidepressant activity of some new 8-thiocarbamoyl-7,8-diazabicyclo[4.3.0]non-6-ene derivatives.
abstract: Several 8-thiocarbamoyl-7,8-diazabicyclo[4.3.0]non-6-enes were prepared by condensing two alpha,beta-unsaturated ketones (2-benzylidene and 2,6-dibenzylidene cyclohexanones) with hydrazine hydrate and reacting the resulting compounds with various isothiocyanates. The structures of the synthesized compounds were confirmed by spectra (IR, 1H-NMR) and microanalysis; they were tested for antidepressant activity using Porsolt's behavioural despair test.
authors: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
authors: A A
authors: AA
authors: Bilgin
authors: A
authors: A
authors: Yesilada
authors: E
authors: E
authors: Palaska
authors: R
authors: R
authors: Sunal
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared
chemical_list: D000928:Antidepressive Agents; D001643:Bridged Bicyclo Compounds; D011720:Pyrazoles