title: Region and age-dependent variation in susceptibility of the human retina to lipid peroxidation.
abstract: Trephined buttons from the posterior central (including the macula) and four peripheral regions of human retina were subjected to in vitro lipid peroxidation initiated by Fe+2. There was an age-related increase in peroxidation in the retinal tissue from the posterior region (P = 0.0019), but not in tissues from any of the four peripheral retinal quadrants (collective P = 0.24). These results suggest that the posterior region of the human retina is susceptible to lipid peroxidation and that age is a factor.
authors: Cullen Eye Institute, Baylor College of Medicine, Houston, Texas 77030.
authors: M
authors: M
authors: De La Paz
authors: R E
authors: RE
authors: Anderson
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D015227:Lipid Peroxidation; D008268:Macular Degeneration / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D012160:Retina / Q000378:metabolism*
chemical_list: D008315:Malondialdehyde