title: Chromosomal localization of the IL-6 receptor signal transducing subunit, gp130 (IL6ST).
abstract: Signal transduction in eukaryotic cells is a complex process mediated, normally, by the interaction of soluble extrinsic protein factors and their cognate receptors. One example of this phenomena is the inflammatory cytokine interleukin-6 and the IL-6 receptor. However, the IL-6 receptor, once its ligand is bound, associates with another membrane glycoprotein, gp130, to potentiate the cytokine response. To further understand the basis of this interaction, and its possible implications in cellular transforming events, the corresponding gene(s) must be studied. Here we find that the human gp130 gene product is homologous to two distinct chromosomal loci on chromosomes 5 and 17. Furthermore, the presence of two distinct gp130 gene sequences is restricted to primates and is not found in other vertebrates.
authors: Department of Tumor Cell Biology, St. Jude Childrens Research Hospital, Memphis, Tennessee.
authors: V J
authors: VJ
authors: Kidd
authors: J E
authors: JE
authors: Nesbitt
authors: G M
authors: GM
authors: Fuller
mesh_terms: D015703:Antigens, CD; D001483:Base Sequence; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D002895:Chromosomes, Human, Pair 5; D003001:Cloning, Molecular; D050822:Cytokine Receptor gp130; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics*; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D011971:Receptors, Immunologic / Q000235:genetics*; D019947:Receptors, Interleukin-6; D015398:Signal Transduction; D013045:Species Specificity
chemical_list: D015703:Antigens, CD; C494199:IL6ST protein, human; D008562:Membrane Glycoproteins; D009838:Oligodeoxyribonucleotides; D011971:Receptors, Immunologic; D019947:Receptors, Interleukin-6; D050822:Cytokine Receptor gp130