Pyoderma gangrenosum--response to topical nitrogen mustard.
We report a 69-year-old caucasian male patient with long-standing pyoderma gangrenosum; the lesions preceded the appearance of an IgA monoclonal gammopathy by 2 years. A number of systemic treatments, including high dose steroids and immunosuppressive agents, were poorly tolerated and resulted in serious side-effects. The skin and haematological conditions, however, were kept under control for 2 years with regular plasmapheresis. Pyoderma gangrenosum recurred as vascular access became exhausted but new lesions healed completely with topical application of 20% nitrogen mustard.
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Unit of Dermatology, Hammersmith Hospital, Royal Postgraduate Medical School, London, UK.
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Chu
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D000287:Administration, Topical; D000368:Aged; D006801:Humans; D007070:Immunoglobulin A; D008297:Male; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000276:immunology; D009588:Nitrogen Mustard Compounds / Q000008:administration & dosage*; D017511:Pyoderma Gangrenosum / Q000188:drug therapy* / Q000276:immunology
D007070:Immunoglobulin A; D009588:Nitrogen Mustard Compounds