Bioavailability of lithium from lithium citrate syrup versus conventional lithium carbonate tablets.
The bioavailability of lithium citrate syrup was compared with that of regular lithium carbonate tablets in 18 healthy male human volunteers. Blood samples were collected up to 48 h after dosing. Lithium serum concentrations were determined by means of AAS. The absorption rate following oral administration of the syrup was greater (tmax 0.8 h) than following administration of regular tablets (tmax 1.4 h). Maximum lithium serum concentrations, however, were only about 10 per cent higher after syrup dosing and serum concentrations resulting from syrup and tablets were almost superimposable from 2 h after dosing. The terminal half-life of lithium was found to be 22 h after syrup as well as after tablet dosing. No side-effects were observed during the study. The bioavailability of lithium from syrup relative to tablets was found to be bioequivalent with respect to the maximum lithium serum concentration and the extent of drug absorption (AUC).
Guelen
P J
PJ
Farma Research B.V., Nijmegen, The Netherlands.
Janssen
T J
TJ
De Witte
T C
TC
Vree
T B
TB
Benson
K
K
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D002951:Citrates; D006801:Humans; D008094:Lithium / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D016651:Lithium Carbonate / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D008297:Male; D013607:Tablets
D002951:Citrates; D013607:Tablets; D016651:Lithium Carbonate; C070669:lithium citrate; D008094:Lithium