NG-011 and NG-012, novel potentiators of nerve growth factor. II. The structure determination of NG-011 and NG-012.
NG-011 and NG-012, novel potentiators of nerve growth factor (NGF) were isolated from the culture broth of Penicillium verruculosum F-4542. The structures of NG-011 and NG-012 were elucidated by their spectral analysis and degradation experiments as shown in Fig. 1.
Ito
M
M
Research Center of Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Tsuchida
Y
Y
Mizoue
K
K
Hanada
K
K
D000818:Animals; D002460:Cell Line; D004357:Drug Synergism; D007783:Lactones / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D009414:Nerve Growth Factors / Q000737:chemistry* / Q000494:pharmacology; D016501:Neurites / Q000187:drug effects; D016716:PC12 Cells; D010407:Penicillium / Q000737:chemistry; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
D007783:Lactones; D009414:Nerve Growth Factors; D010636:Phenols; C078926:NG 011