Coexistent cutaneous T-cell lymphoma and B-cell chronic lymphocytic leukaemia.
Three patients with cutaneous T-cell lymphoma (CTCL) are reported who had concurrent B-cell chronic lymphocytic leukaemia (B-CLL). The separate lineage and clonal nature of the individual lymphoid malignancies were confirmed by gene-rearrangement analysis. The chronology of the illnesses did not support the hypothesis that CTCL predisposes to the development of B-cell proliferative disorders. There was no clear association with immunosuppressive therapy, and HTLV-1 studies were negative in all patients. Consequently, we speculate that a lymphoid stem cell defect, which may lead to the development of either aberrant B- or T-cell clones, may be responsible for such cases of dual lymphoid neoplasia.
Harland
C C
CC
Department of Dermatology, St Helier Hospital, Carshalton, U.K.
Whittaker
S J
SJ
Ng
Y L
YL
Holden
C A
CA
Wong
E
E
Smith
N P
NP
D000368:Aged; D000369:Aged, 80 and over; D015139:Blotting, Southern; D004247:DNA / Q000235:genetics; D015322:Gene Rearrangement, B-Lymphocyte; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D007124:Immunoenzyme Techniques; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics / Q000473:pathology*; D016410:Lymphoma, T-Cell, Cutaneous / Q000235:genetics / Q000473:pathology*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D012867:Skin / Q000276:immunology; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology*
D004247:DNA