The dopamine D1 receptor antagonist SCH-23390 decreases the mRNA levels of the transcription factor zif268 (krox-24) in adult rat intact striatum--an in situ hybridization study.
By in situ hybridization with an oligonucleotide probe, we have studied the cellular distribution of the messenger RNA encoding the transcription factor zif268 (krox-24) in the adult intact rat striatum and regulation of its synthesis by acute treatment with the dopamine D1 receptor antagonist SCH-23390. Zif268 mRNA was found in the striatal medium-sized neurons and not in the large cells. Its levels were decreased by SCH-23390, suggesting activation of this immediate early gene in the striatum through dopamine D1 receptor stimulation.
Mailleux
P
P
Laboratory of Neurophysiology, Université Libre de Bruxelles, Belgium.
Zhang
F
F
Vanderhaeghen
J J
JJ
D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D015342:DNA Probes; D017403:In Situ Hybridization; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors*; D014157:Transcription Factors / Q000096:biosynthesis*
D001552:Benzazepines; D015342:DNA Probes; D012333:RNA, Messenger; D017447:Receptors, Dopamine D1; D014157:Transcription Factors