title: Aging, energy expenditure and nutritional status: evidence for denutrition-related hypermetabolism.
abstract: Resting energy expenditure (REE) and nutritional status have been evaluated in 39 elderly inpatients (mean age 84.0 +/- 6.9 years). The nutritional status declined with aging as shown by significant negative correlations between age and, respectively, weight (p < 0.001), fat free mass (FFM) (p < 0.01) and body mass index (BMI) (p < 0.01). The best prediction for REE when considering the whole population was given by FFM (p < 0.001). Increased REE was observed in patients after recent surgery, related to an inflammatory state, as shown by increased plasma levels of C-reactive protein and orosomucoid. Irrespectively of the inflammatory state, REE was also found to be related to the nutritional status: patients who showed a BMI < 20 had higher REE than patients with a BMI > 20 (28.4 +/- 1.3 vs. 22.1 +/- 0.7 kcal/kg of body weight; p < 0.001; 35.7 +/- 1.6 vs. 30.9 +/- 1.0 kcal/kg of FFM; p < 0.02). These results increasingly suggest that elderly patients may suffer from denutrition relevant to hypermetabolism.
authors: Service d'Hépato-gastroentérologie et de Rééducation digestive, Hôpital Albert Chenevier, Créteil, France.
authors: B
authors: B
authors: Campillo
authors: P N
authors: PN
authors: Bories
authors: M
authors: M
authors: Devanlay
authors: B
authors: B
authors: Pornin
authors: J C
authors: JC
authors: Le Parco
authors: E
authors: E
authors: Gaye-Bareyt
authors: P
authors: P
authors: Fouet
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D001481:Basal Metabolism; D001823:Body Composition; D015992:Body Mass Index; D001835:Body Weight; D002097:C-Reactive Protein / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D009748:Nutrition Disorders / Q000378:metabolism; D009752:Nutritional Status; D009961:Orosomucoid / Q000378:metabolism
chemical_list: D009961:Orosomucoid; D002097:C-Reactive Protein