[The phenotypic characteristics of T-lymphocytes that interact with hematopoietic stem cells: the expression of the antigens Lyt-1, Lyt-2 and L3T4].
The role of T-lymphocytes, bearing antigens Lyt-1, Lyt-2 and L3T4, in regulation of the functional activity of blood-forming precursor cells of syngen and non-syngen origin was investigated. The treatment of cells of murine lymphatic nidi with monoclonal antibodies to the above antigens and with the complement did not abolish the capacity of T-lymphocytes of controlling proliferation and differentiation of syngen and allogen blood-forming precursor cells. The subpopulation characteristics of lymphocytes interacting with the stem cells is discussed.
Man'ko
V M
VM
Osipova
E Iu
EIu
Rudneva
T B
TB
Blagonravova
O L
OL
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D000950:Antigens, Ly / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology / Q000528:radiation effects; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation / Q000276:immunology; D002450:Cell Communication / Q000276:immunology / Q000528:radiation effects; D002454:Cell Differentiation / Q000276:immunology / Q000528:radiation effects; D003114:Colony-Forming Units Assay; D003165:Complement System Proteins / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000276:immunology / Q000528:radiation effects; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology / Q000528:radiation effects / Q000637:transplantation; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010641:Phenotype; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology / Q000528:radiation effects
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000950:Antigens, Ly; D003165:Complement System Proteins
Fenotipicheskaia kharakteristika T-limfotsitov, vzaimodeĭstvuiushchikh s krovetvornymi stvolovymi kletkami: ékspressiia antigenov Lyt-1, Lyt-2 i L3T4.