Effect of an environmental contaminant, diisopropyl methylphosphonate, on the blood pressure of the mallard.
During a toxicological test using diisopropyl methylphosphonate (DIMP) on mallards, an anaesthesia-like response was noted after oral dosing. In order to further elucidate these effects, arterial blood pressures were determined both pre- and post-dosing on adult male and female mallards by cannulation of the left carotid artery. A significant decrease in systolic, diastolic, and mean blood pressure was noted after the oral administration of DIMP. There was no significant difference in response between males and females. During the first 30 min after dosing, systolic pressure fell from an average of 158 mmHg, to 94 mmHg, diastolic decreased from 127 mmHg to 63 mmHg, and mean blood pressure dropped from 138 mmHg to 75 mmHg. However, there was no significant effect on pulse pressure, heart rate, or respiratory rate. These results are compared to physiological data cited in the literature for various CNS-acting drugs on mallards.
Jones
R E
RE
DABT, Texas Instruments, Dallas 75265.
Howell
K S
KS
Ringer
R K
RK
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004372:Ducks; D004785:Environmental Pollutants / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D012727:Sex Characteristics
D004785:Environmental Pollutants; D009943:Organophosphorus Compounds; C023477:diisopropyl methylphosphonate