[Evaluation of the fluidifying effect on nasal mucus of physiologic solution combined with increasing concentrations of polysorbates].
Nasal decongestants are widely used in the treatment of rhinitis. Decongestant drugs are one of the main components, but numerous reports gave been made concerning side, local and general effects. The problem is particularly important in the treatment of infantile rhinitis for which the use of saline solution alone is often preferred. The paper evaluates the fluidifying action of a saline solution and polysorbate 20, a tensioactive molecule, on nasal mucous. Changes in mucous viscosity were assessed using a "filancemeter" and thromboelastograph. At the same time a clinical study on the efficacy of treatment and the possible presence of side effects was carried out in a population of rhinitic subjects. The study highlighted the fluidifying effect of the preparation on nasal mucous and the complete absence of side effects.
Luisetti
M
M
Istituto di Tisiologia, Università degli Studi di Pavia.
Mevio
E
E
D000281:Administration, Intranasal; D000328:Adult; D006801:Humans; D007552:Isotonic Solutions / Q000008:administration & dosage / Q000627:therapeutic use*; D009093:Mucus / Q000187:drug effects*; D011136:Polysorbates / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D012220:Rhinitis / Q000188:drug therapy*; D014783:Viscosity / Q000187:drug effects
D007552:Isotonic Solutions; D011136:Polysorbates
Valutazione della efficacia fluidificante sul muco nasale di soluzione fisiologica unita a concentrazioni crescenti di polisorbati.