title: [A screening method for rapid detection of barbiturates in serum using tandem mass spectrometry].
abstract: A mass spectrometric screening method for the detection of barbiturates in serum will be presented. Fragmentation of barbiturates under EI conditions leads to a loss of HNCO. Therefore, "neutral loss scans" of 43 u allow the indication of possibly existing representatives of this class of compounds. Identification can be achieved by "daughter" or "parent ion scans". Thus, 10 micrograms/ml apro-, pento- and phenobarbital could be detected in serum.
authors: Institut für Organische Chemie II, Universität Koln.
authors: P
authors: P
authors: Bold
authors: H
authors: H
authors: Brzezinka
authors: H
authors: H
authors: Budzikiewicz
mesh_terms: D001463:Barbiturates / Q000493:pharmacokinetics*; D006801:Humans; D013058:Mass Spectrometry; D010424:Pentobarbital / Q000493:pharmacokinetics; D010634:Phenobarbital / Q000493:pharmacokinetics
chemical_list: D001463:Barbiturates; D010424:Pentobarbital; C006470:allylpropymal; D010634:Phenobarbital
vernacular_title: Eine Screening-Methode zum schnellen Nachweis von Barbituraten im Serum mittels Tandem-Massenspektrometrie.