title: Immediate positive pressure ventilation with positive end-expiratory pressure (PEEP) improves survival in ovine smoke inhalation injury.
abstract: BACKGROUND
  The purpose of this study was to compare the effects of immediate initiation of positive pressure ventilation (PPV) with positive end-expiratory pressure (PEEP) versus the initiation of PPV with PEEP only after hypoxemia ensued following severe smoke inhalation injury.
  
  
  METHODS
  We prospectively evaluated chronically instrumented adult sheep treated with immediate versus delayed PPV with PEEP and compared oxygen requirements, hemodynamics, pleural fluid formation, postinjury survival, and tracheobronchial pathologic processes among groups. The immediate group (group I; smoke, n = 6; sham, n = 2) underwent tracheostomy and bilateral chest tube placement before they received inhalation injury. They were then immediately placed on PPV with PEEP (12 cm H2O). The animals in the delayed group (group D) (n = 6) were placed on PPV with PEEP when arterial hypoxemia (PaO2 < 80 mm Hg [11.2 kPa] on 0.4 FIO2) or respiratory distress developed.
  
  
  RESULTS
  Groups were matched for smoke exposure and peak carboxyhemoglobin. Both groups developed a characteristic decrease in PaO2/FIO2 ratio. Initiation of PPV + PEEP improved PaO2 in the delayed group (69 +/- 7 to 126 +/- 21 mm Hg [9.2 +/- 0.9 to 16.7 +/- 2.8 kPa]). Pleural fluid output was greater in the immediate group compared with the delayed group (1559 +/- 415 vs. 426 +/- 236 mL). At 96 hours after injury five of six animals in the delayed group had died. In contrast, six of six animals in the immediate smoke group survived 96 hours (p < 0.05 versus delayed group). The immediate group had fewer and less extensive tracheobronchial casts at necropsy.
  
  
  CONCLUSIONS
  Immediate PPV + PEEP did not prevent the development of hypoxia and was associated with increased pleural fluid formation. Death within 96 hours in the delayed group was the result of respiratory failure aggravated by bronchial cast formation despite vigorous pulmonary toilet. Early positive pressure ventilation with PEEP, preferably initiated immediately after the inhalation insult, significantly increases short-term survival and is associated with decreased tracheobronchial cast formation in this ovine model of severe smoke inhalation injury.
authors: Department of Surgery, University of Texas Medical Branch, Galveston 77550.
authors: C S
authors: CS
authors: Cox
authors: J B
authors: JB
authors: Zwischenberger
authors: D L
authors: DL
authors: Traber
authors: P K
authors: PK
authors: Minifee
authors: N
authors: N
authors: Navaratnam
authors: A K
authors: AK
authors: Haque
authors: D N
authors: DN
authors: Herndon
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D000860:Hypoxia / Q000209:etiology / Q000628:therapy; D011175:Positive-Pressure Respiration; D011446:Prospective Studies; D012756:Sheep; D015208:Smoke Inhalation Injury / Q000150:complications / Q000401:mortality / Q000628:therapy*; D015996:Survival Rate; D013997:Time Factors