title: Human serum carboxypeptidase U: a new kininase?
abstract: A carboxypeptidase capable of cleaving basic amino acids from synthetic peptide substrates is present in fresh human serum, and not in human heparinized plasma. Its activity is generated during the process of coagulation. Because of its instability at room temperature and at 37 degrees C, we named it "unstable carboxypeptidase" (carboxypeptidase U, CPU). The enzymatically active subunit of carboxypeptidase U was purified and exhibits a single band at 53 kDa on SDS-PAGE.
authors: Department of Pharmaceutical Sciences, University of Antwerp, Wilrijk, Belgium.
authors: D
authors: D
authors: Hendriks
authors: W
authors: W
authors: Wang
authors: M
authors: M
authors: van Sande
authors: S
authors: S
authors: Scharpé
mesh_terms: D002268:Carboxypeptidases / Q000097:blood* / Q000737:chemistry / Q000302:isolation & purification; D002852:Chromatography, Ion Exchange; D004591:Electrophoresis, Polyacrylamide Gel; D004795:Enzyme Stability; D006801:Humans; D008970:Molecular Weight; D011487:Protein Conformation; D013379:Substrate Specificity
chemical_list: D002268:Carboxypeptidases