title: Fertility of male and female mice heterozygous for the reciprocal translocation T(7;17)3BKM.
abstract: The present paper describes the fertility of male and female mice heterozygous for the reciprocal translocation T(7;17)3BKM. This translocation was induced by gamma rays in the spermatozoa of an irradiated parent. It is characterized by "asymmetrical" localization of the breakpoints, distally in Chromosome 7 (7F5) and proximally in Chromosome 17 (17B1). The data presented here relate only those matings in which, for both partners, heterozygosity or normality could be confirmed cytogenetically. The results indicate that both male and female translocation heterozygotes are fertile, their mean litter size being reduced to about 50% of that of normal littermates. This leads to the conclusion that the multivalents mainly undergo either alternate or adjacent-1 2:2 segregation. No viable tertiary trisomics were observed among the progeny of the translocation carriers. Analysis of the frequency of the different types of multivalents in diakinesis-metaphase I spermatocytes showed a significant predominance of chain-type figures (CIV and CIII+I), with chains of four elements (CIV) being more frequent than other configurations. This demonstrates that the small marker chromosome remains attached by one of its segments to the tetravalent.
authors: Institute of Radiobiology and Radiation Hygiene, Medical Academy, Sofia, Bulgaria.
authors: M
authors: M
authors: Koleva
authors: D
authors: D
authors: Benova
mesh_terms: D000818:Animals; D002871:Chromosome Banding; D005260:Female; D005298:Fertility / Q000235:genetics*; D006579:Heterozygote; D007621:Karyotyping; D008297:Male; D008677:Metaphase; D051379:Mice; D008810:Mice, Inbred C57BL; D014178:Translocation, Genetic