Fibrin ring granulomas in hepatitis A.
Fibrin ring granuloma is characterized by a fibrinous ring surrounding a central fat vacuole. It has been found in the liver and bone marrow of patients with Q fever, and occasionally with visceral leishmaniasis, cytomegalovirus, Epstein-Barr virus, Staphylococcus epidermidis infections, Hodgkin's lymphoma, and hypersensitivity to allopurinol. We describe a case of serologically confirmed viral hepatitis A with this lesion in the liver biopsy. A false positive anti-hepatitis A virus IgM result has been excluded. This is, to our knowledge, the second reported case of type A hepatitis with hepatic fibrin ring granulomas. It confirms that hepatitis A should be included in the differential diagnosis of this lesion.
Ruel
M
M
Médecine interne et gastro-entérologie, Hôpital de Senlis, Senlis, France.
Sevestre
H
H
Henry-Biabaud
E
E
Courouce
A M
AM
Capron
J P
JP
Erlinger
S
S
D000208:Acute Disease; D005260:Female; D005337:Fibrin / Q000378:metabolism*; D006099:Granuloma / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D006506:Hepatitis A / Q000150:complications* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology*; D008107:Liver Diseases / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D011778:Q Fever / Q000473:pathology
D005337:Fibrin