The acute phase response in autologous bone marrow transplantation.
Due to the stress imposed by the process of bone marrow transplantation (BMT), we hypothesized that individuals receiving such a transplant underwent an acute phase response (APR). Circulating levels of C-reactive protein (CRP), haptoglobin (HAP), alpha-1 acid glycoprotein (AAG), ceruloplasmin (CER), zinc (Zn), copper (Cu), interleukin-6 (IL-6), albumin (ALB), and thyroxine-binding prealbumin (TBPA), were measured at baseline (Day -7), Day -4, Day 0 (Transplant Day), Day +2, +7, and weekly until day 28 in 14 adults receiving an autologous bone marrow transplant as Phase 1 treatment for various hematologic or solid tumor malignancies. Ten of 14 recipients survived, 9 of which had a significant increase in CRP (p = 0.012), HAP (p = 0.011), AAG (p = 0.002), and decrease in ALB (p = 0.002) and TBPA (p = 0.004) on Day +7, but not Day 0, after bone marrow reinfusion. These findings document the presence of an APR and suggest that the bone marrow transplant process (post reinfusion) initiates a stress response in the recipient.
Boosalis
M G
MG
Department of Clinical Sciences, University of Kentucky, Lexington 40536-0080.
Gray
D
D
Walker
S
S
Sutliff
S
S
Talwalker
R
R
Mazumder
A
A
D000210:Acute-Phase Reaction / Q000097:blood / Q000209:etiology* / Q000473:pathology; D000328:Adult; D015415:Biomarkers; D001835:Body Weight; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000473:pathology; D002097:C-Reactive Protein / Q000378:metabolism; D002570:Ceruloplasmin / Q000378:metabolism; D003300:Copper / Q000097:blood; D005260:Female; D006242:Haptoglobins / Q000378:metabolism; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009961:Orosomucoid / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism; D013975:Thyroxine-Binding Proteins / Q000378:metabolism; D014182:Transplantation, Autologous; D015032:Zinc / Q000097:blood
D015415:Biomarkers; D006242:Haptoglobins; D015850:Interleukin-6; D009961:Orosomucoid; D012709:Serum Albumin; D013975:Thyroxine-Binding Proteins; D003300:Copper; D002097:C-Reactive Protein; D002570:Ceruloplasmin; D015032:Zinc