title: [Immunologic aspects of the fetal growth retardation syndrome].
abstract: Serial measurements of allo- and autoimmune lymphocytotoxic antibodies (LCT-AB), circulating immune complexes (CIC) and heterophilic hemolysins were carried out over pregnancy weeks 24-40 in 63 pregnant women with small-for-date fetuses, 63 ones with other pregnancy complications, and in 15 ones with normal pregnancy. The mean allo- and auto-LCT-AB levels remained unchanged over the course of pregnancy and were virtually the same in all the examinees. CIC and heterophilic hemolysin levels were found growing in women with small-for-date fetuses starting from pregnancy week 28, as against the two reference groups. A direct relationship between abnormally high heterophilic hemolysin levels and blood rheology disorders could be traced. The incidence of unfavorable perinatal outcomes was increasing if heterophilic hemolysin levels surpassed 1.1 U optic density and the placenta was thin. These results permit considering the small-for-date fetus syndrome as a manifestation of immunity conflict in pregnancy.
authors: L G
authors: LG
authors: Nazarenko
authors: L V
authors: LV
authors: Antipenskaia
mesh_terms: D000293:Adolescent; D000328:Adult; D000910:Antibodies, Heterophile / Q000032:analysis / Q000276:immunology; D000936:Antigen-Antibody Complex / Q000032:analysis / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis / Q000276:immunology; D001327:Autoimmune Diseases / Q000097:blood / Q000150:complications / Q000276:immunology*; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology* / Q000276:immunology; D006460:Hemolysin Proteins / Q000032:analysis / Q000276:immunology; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008393:Marriage; D010920:Placenta / Q000276:immunology*; D010927:Placental Insufficiency / Q000097:blood / Q000150:complications / Q000276:immunology*; D011247:Pregnancy
chemical_list: D000910:Antibodies, Heterophile; D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D006460:Hemolysin Proteins
vernacular_title: Ob immunologicheskikh aspektakh sindroma zaderzhki razvitiia ploda.