title: Porcine dermal collagen as a wound dressing for skin donor sites and deep partial skin thickness burns.
abstract: Collagen was extracted by pepsin digestion from porcine skin, and collagen membrane was prepared by salt precipitation. The porcine collagen membrane was evaluated as a burn wound dressing in deep partial skin thickness burn wounds in rats. Burn wounds, 4 x 4 cm, were inflicted by exposure of skin to 75 degrees C for 15 s followed by de-epithelialization. Wound healing was assessed by planimetry of epithelialization on day 10 after injury. Open wounds exhibited 24 per cent of wound area re-epithelialized. Collagen membrane dressing significantly improved the healing to 69 per cent of wound area (P < 0.0001). In a completely separate experiment, the porcine collagen membrane was applied as a wound dressing to the donor sites of burn patients, and its effect on wound healing was compared with that of a petroleum jelly gauze dressing. The donor sites covered with petroleum jelly gauze had re-epithelialized by an average of 14.5 days (ranging from 13 to 16 days) after wounding. The wounds dressed with collagen membrane demonstrated a significant increase in the healing rate. Complete re-epithelialization was observed by 10.3 days (ranging from 10 to 12 days) after wounding (P < 0.0001).
authors: Department of Burn Surgery, Affiliated Hospital of Qinghai Medical College, Xining, People's Republic of China.
authors: Z R
authors: ZR
authors: Gao
authors: Z Q
authors: ZQ
authors: Hao
authors: Y
authors: Y
authors: Li
authors: M J
authors: MJ
authors: Im
authors: R J
authors: RJ
authors: Spence
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001684:Biological Dressings; D002056:Burns / Q000473:pathology / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D003094:Collagen / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D010577:Petrolatum; D051381:Rats; D017207:Rats, Sprague-Dawley; D016038:Skin Transplantation / Q000473:pathology; D014945:Wound Healing
chemical_list: D010577:Petrolatum; D003094:Collagen