[Effects of sex hormones on large bowel carcinogenesis induced by 1,2-dimethylhydrazine in Sprague-Dawley rats].
The effects of sex hormones on colorectal carcinogenesis induced by 1,2-dimethylhydrazine (DMH) were studied in Sprague-Dawley (SD) rats. The morbidity of large bowel carcinomas in group castration + estrogen (E2) + DMH (88%) was significantly higher than that in group male + DMH (56%), group castration+DMH (21%) and group castration+androgen + DMH (57%) respectively (P < 0.05, P < 0.01, P < 0.05). Part of tumors from those groups treated with DMH were analysed in detecting the possible presence of estrogen receptors(ER). Data showed that 3 out of 8 tumors (38%) in group castration + estrogen + DMH, 2 out of 7 (29%) in group male + DMH, 1 from 4 (25%) in group castration + DMH and 2 out of 6 (33%) in group castration + androgen + DMH contained E2-HRP receptor. The results also show that sex hormones, especially estradiol may inhibit ConA-induced lymphocyte transformation; promote cholesterol and bile metabolism and excretion in the liver; enhance pH value in colorectum and stimulate colonic epithelial proliferation which may elucidate the effects of sex hormones on colorectal carcinogenesis induced by DMH.
Huang
P L
PL
Department of Pathology, Nanjing Railway Medical College.
D000818:Animals; D002369:Castration; D003043:Cocarcinogenesis; D015179:Colorectal Neoplasms / Q000139:chemically induced* / Q000473:pathology; D004127:Dimethylhydrazines; D004958:Estradiol / Q000502:physiology*; D008213:Lymphocyte Activation; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D011960:Receptors, Estrogen / Q000032:analysis; D013739:Testosterone / Q000502:physiology*
D004127:Dimethylhydrazines; D011960:Receptors, Estrogen; D013739:Testosterone; D004958:Estradiol