[Meningeal infiltration in multiple myeloma. Study of a new case and literature review].
A patient with lambda light-chains Bence-Jones multiple myeloma (MM) showed a meningeal myelomatosis during a relapse of his illness. Meningeal infiltration was showed through the detection of plasmatic cells in cerebro spinal fluid, identified morphologic and immunophenotypically, together with hyperproteinemia constituted exclusively by lambda light-chains. Treatment was given, intrathecal (methotrexate and cytosine arabinoside) and systemic (vincristine, adriamycin and dexamethasone) chemotherapy, with disappearance of meningeal infiltration. However the patient died, after three months evolution of MM, tough. Literature on this topic is reviewed.
Escorsell
A
A
Escuela de Hematología Farreras Valentí, Servicio de Hematología, Hospital Clínico y Provincial, Barcelona.
López-Guillermo
A
A
Blade
J
J
Villamor
N
N
Massanes
F
F
Montserrat
E
E
Rozman
C
C
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000188:drug therapy / Q000473:pathology*; D009101:Multiple Myeloma / Q000188:drug therapy / Q000473:pathology*; D009361:Neoplasm Invasiveness
Infiltración meníngea en el mieloma múltiple. Estudio de un nuevo caso y revisión de la bibliografía.