Cyclosporin A protects against ischemia-reperfusion injury in the brain.
We investigated the protective effect of Cyclosporin A (CsA) against ischemia-reperfusion injury in the brain using a transient focal ischemia model in rats. In CsA-treated rats, ischemic brain edema formation 1 day after reperfusion in the cerebral cortex perfused by the middle cerebral artery (MCA) and infarct size were decreased compared with those in olive oil treated control rats. These results suggest that CsA is beneficial in reducing ischemia-reperfusion injury, possibly by the suppression of immunological reactions.
Shiga
Y
Y
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
Onodera
H
H
Matsuo
Y
Y
Kogure
K
K
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001806:Blood Urea Nitrogen; D001929:Brain Edema / Q000473:pathology; D001930:Brain Injuries / Q000473:pathology / Q000517:prevention & control*; D002536:Cerebral Arteries / Q000502:physiology; D016572:Cyclosporine / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000473:pathology*
D016572:Cyclosporine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase