[Postprandial lipemia under treatment with Allium sativum. Controlled double-blind study of subjects with reduced HDL2-cholesterol].
Postprandial Lipaemia under Treatment with Allium sativum/Controlled double-blind study in healthy volunteers with reduced HDL2-cholesterol levels. The effectiveness of a standardized garlic powder preparation (Sapec, Kwai) on alimentary hypertriglyceridaemia after intake of a standardized fatty test meal containing 100 g butter was analyzed in a randomized placebo-controlled double-blind study. 24 volunteers with HDL2-cholesterol concentrations in plasma of less than 10 mg/dl (men) respectively 15 mg/dl (women) participated in the study. The volunteers received 3 times 1 tablet daily over a period of 6 weeks equivalent to a daily dosage of 900 mg garlic powder in the active treated group. Control measurements were made on the 1st, 22nd and 43rd day of treatment and 0, 3 and 5 h after intake of the meal. The postprandial increase of triglycerides was clearly reduced under garlic medication as compared to placebo treatment. The determined AUC-values for the triglycerides were up to 35% lower in the garlic group compared to the placebo group. The regular intake of the garlic preparation over the period of 6 weeks showed a significant lowering of the fasting values of triglycerides in comparison to placebo. Under garlic medication HDL2-cholesterol increased more than under placebo in tendency.
Rotzsch
W
W
Institut für Klinische Chemie und Laboratoriumsdiagnostik, Universität Leipzig.
Richter
V
V
Rassoul
F
F
Walper
A
A
D000328:Adult; D008076:Cholesterol, HDL / Q000097:blood; D004041:Dietary Fats / Q000378:metabolism; D004311:Double-Blind Method; D005260:Female; D005737:Garlic; D006801:Humans; D015228:Hypertriglyceridemia / Q000188:drug therapy*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010946:Plants, Medicinal; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D004041:Dietary Fats; D008055:Lipids; D014280:Triglycerides
Postprandiale Lipämie unter Medikation von Allium sativum. Kontrollierte Doppelblindstudie bei Probanden mit erniedrigtem HDL2-Cholesterin.