Orthotopic liver transplantation for hepatic GVHD following allogeneic BMT for chronic myeloid leukaemia.
A 21-year-old man who had an HLA-identical sibling donor BMT for chronic myeloid leukaemia developed grade IV acute GVHD of the liver that was unresponsive to corticosteroids and anti-IL2 receptor monoclonal antibody. He was treated with an orthotopic liver transplant and is currently well 6 months later with normal liver function and no evidence of GVHD in the transplanted liver.
Marks
D I
DI
Department of Haematology, Hammersmith Hospital, London, UK.
Dousset
B
B
Robson
A
A
Imvrios
G
G
Buckels
J A
JA
Elias
E
E
Neuberger
J M
JM
Foster
C
C
Batchelor
R
R
Goldman
J M
JM
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D006086:Graft vs Host Disease / Q000209:etiology / Q000601:surgery*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000601:surgery*; D008107:Liver Diseases / Q000209:etiology / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male