[Carnosine and anserine as specialized pH-buffers--hydrogen ion carriers].
Data are reviewed that carnosine (pK 6.9) and anserine (pK 7.1) act as specific mobile pH buffers promoting a rapid elimination of pH gradients between different parts of muscle fibers (very large cells containing various structural components, such as actomyosin, Z-discs, mitochondrial and sarcoplasmic reticulum, etc.). The specific role of these muscle dipeptides as pH buffers (H(+)-translocators) provides explanation for the so-called "Severin phenomenon"-a manyfold enhancement by carnosine of the ability of the isolated muscle to contract and accumulate lactate.
Skulachev
V P
VP
D000818:Animals; D000861:Anserine / Q000737:chemistry*; D001692:Biological Transport; D002021:Buffers; D002336:Carnosine / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry / Q000378:metabolism; D007477:Ions
D002021:Buffers; D007477:Ions; D006859:Hydrogen; D002336:Carnosine; D000861:Anserine
Karnozin i anzerin kak spetsializirovannye pH-bufery--perenoschiki ionov vodoroda.