Dose-response relationships of alimentary PtCl2 and PtCl4 in growing rats.
In experiments with rats dose-response relationships of alimentary PtCl2 and PtCl4 were investigated. 2 x 81 animals weighing 35 g were randomly distributed among 9 treatment groups which were fed ad libitum with a synthetic diet containing various amounts of Pt during 4 weeks. Pt was added in the form of PtCl2 or PtCl4 in the amounts 0; 0.01; 0.05; 0.10; 0.50; 1.0; 5.0; 10 and 50 mg/kg diet. The Pt supplementation had no influence on life mass gain or food consumption. In the case of 50 mg/kg Pt in the form of PtCl4 the erythrocyte count and hematocrit were reduced by about 13% in comparison with the control group. Dependent on the Pt dose, the application of PtCl4 and PtCl2 induced Pt retention in nearly all tissues especially in kidney. The effects were greater with PtCl4 than with PtCl2. As a result of the higher Pt retention in the kidneys, the serum creatinine was increased for the higher doses of PtCl4.
Reichlmayr-Lais
A M
AM
Institut für Ernährungsphysiologie, Technische Universität München, Freising-Weihenstephan, Fed. Rep. of Germany.
Kirchgessner
M
M
Bader
R
R
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D004906:Erythrocyte Count / Q000187:drug effects*; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D008297:Male; D010984:Platinum / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D017671:Platinum Compounds; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
D006454:Hemoglobins; D017671:Platinum Compounds; C030173:platinum chloride; D010984:Platinum; C032741:platinum tetrachloride