[Effect of antenatal action of Thio-Tepa on spermatogenesis of mature 101/N and CBA mice].
On pregnancy day 12 101/H and CBA mice were injected intraperitoneally 2.5 mg/kg bw thiophosphamide. 3.5-month-old male offspring were sacrificed. The drug effect on the testes was evaluated by karyologic analysis of the germ cell generations on stage 7 of the seminiferous epithelium cycle. A reliable reduction in the number of spermatogonia A, preleptotene and pachytene spermatocytes and spermatids at development stage 7 was found in 101/H mice. There were interspecific differences in spermatogenesis intensity in intact animals and recovery of germ cell pool after thiophosphamide action inducing toxicity.
Khil'kevich
L V
LV
Kurilo
L F
LF
Zhubinskaia
V P
VP
Lil'p
I G
IG
D000367:Age Factors; D000818:Animals; D005260:Female; D005333:Fetus / Q000187:drug effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D011247:Pregnancy; D013087:Spermatids / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects; D013852:Thiotepa / Q000633:toxicity*
D013852:Thiotepa
Effekt antenatal'nogo vozdeĭstviia tioTEF na spermatogenez polovozrelykh mysheĭ liniĭ 101/N i CBA.