title: Localization of the human CYP17 gene (cytochrome P450(17 alpha)) to 10q24.3 by fluorescence in situ hybridization and simultaneous chromosome banding.
abstract: The gene for human P450(17 alpha) (CYP17) was previously mapped to chromosome 10 through analysis of somatic cell hybrids. Using a modified procedure of fluorescence in situ hybridization, this gene has now been visualized on simultaneously banded chromosomes and localized to a specific subband of chromosome 10 at q24.3. This precise assignment may facilitate the understanding of the molecular basis of 17 alpha-hydroxylase/17,20-lyase deficiency and the evolution of the CYP superfamily of genes.
authors: Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada.
authors: Y S
authors: YS
authors: Fan
authors: R
authors: R
authors: Sasi
authors: C
authors: C
authors: Lee
authors: J S
authors: JS
authors: Winter
authors: M R
authors: MR
authors: Waterman
authors: C C
authors: CC
authors: Lin
mesh_terms: D002871:Chromosome Banding; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D004247:DNA; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D013254:Steroid 17-alpha-Hydroxylase / Q000235:genetics*
chemical_list: D004247:DNA; D003577:Cytochrome P-450 Enzyme System; D013254:Steroid 17-alpha-Hydroxylase; C022433:pregnenolone 17-alpha-hydroxylase