Repeated focal cerebral ischemia in gerbils is associated with development of infarction.
We induced repeated focal cerebral ischemia in gerbils. Single 5-min ischemia produced neuronal damage limited to the ipsilateral CA1 and CA4 hippocampus. Two 5-min ischemic insults spaced at a 1-h interval caused selective neuronal damage to the CA1, CA3 and CA4 hippocampus, striatum, neocortex, and thalamus. Three 5-min ischemic insults at 1-h intervals produced infarction. Thus, repeated focal ischemia produced cumulative brain damage by conversion of sublethal damage into selective neuronal damage and of the neuronal damage into infarction.
Kato
H
H
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
Araki
T
T
Kogure
K
K
D000818:Animals; D001921:Brain / Q000473:pathology; D001925:Brain Damage, Chronic / Q000209:etiology; D002545:Brain Ischemia / Q000150:complications* / Q000473:pathology; D002544:Cerebral Infarction / Q000209:etiology* / Q000473:pathology; D005849:Gerbillinae; D008297:Male; D009474:Neurons / Q000473:pathology; D012008:Recurrence; D013997:Time Factors