title: Dactylocyclines, novel tetracycline derivatives produced by a Dactylosporangium sp. III. Absolute stereochemistry of the dactylocyclines.
abstract: The dactylocycline antibiotics were found through circular dichroism measurements, NMR spectroscopy and chemical transformations to possess the usual tetracycline family absolute configuration at carbons 4, 4a, 5a and 12a. The absolute stereochemistry about the C-6 carbon, however, was the reverse of that found with previously investigated tetracyclines.
authors: Department of Medicinal Chemistry, University of Kansas, Lawrence 66045-2506.
authors: P V
authors: PV
authors: Devasthale
authors: L A
authors: LA
authors: Mitscher
authors: H
authors: H
authors: Telikepalli
authors: D
authors: D
authors: Vander Velde
authors: J Y
authors: JY
authors: Zou
authors: H A
authors: HA
authors: Ax
authors: A A
authors: AA
authors: Tymiak
mesh_terms: D000192:Actinomycetales / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002751:Chlortetracycline / Q000031:analogs & derivatives* / Q000737:chemistry; D002942:Circular Dichroism; D009682:Magnetic Resonance Spectroscopy; D013237:Stereoisomerism; D000095702:Polyether Toxins
chemical_list: D000900:Anti-Bacterial Agents; D002751:Chlortetracycline; C054353:dactylocyclinone; C079467:dactylocycline A; D000095702:Polyether Toxins; C079466:dactylocycline B