[Effects of systemically-administered beta-casomorphin-7 on nociception in rats].
The influence of food-derived heptapeptide beta-casomorphin-7 (beta-CM-7) on pain sensibility of white rats was studied by tail flick test. As shown for doses 10 and 20 mg/kg intraperitoneally, injected beta-CM-7 induced significant analgesia; lower peptide concentration (5 mg/kg) was ineffective. As a whole, there is a significant positive correlation between the intensity of analgesia and the quantity of administered exorphine. These changes of pain sensibility were observed for one hour after injection of heptapeptide; further measurements showed no significant difference of time reaction between control and experimental groups of rats. It was found out that animals with high native level of pain sensibility (4-8 sec) made the main contribution to manifestation of analgesia.
Dubynin
V A
VA
Maklakova
A S
AS
Nezavibat'ko
V N
VN
Alfeeva
L A
LA
Kamenskiĭ
A A
AA
Ashmarin
I P
IP
D000818:Animals; D002364:Caseins / Q000494:pharmacology*; D004723:Endorphins / Q000494:pharmacology*; D010147:Pain Measurement; D017288:Pain Threshold / Q000187:drug effects*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D002364:Caseins; D004723:Endorphins; D010446:Peptide Fragments; C041128:beta-casomorphin 7
Deĭstvie beta-kazomorfina-7 na notsitseptsiiu krys pri sistemnom vvedenii.