Is the "K-type" caffeine-halothane responder susceptible to malignant hyperthermia?
The "K-type" designation is used to describe a patient being investigated for malignant hyperthermia (MH) when concurrent administration of caffeine and halothane induces muscle contracture (rigidity, spasm) in vitro, but when halothane and caffeine given separately produce a normal response. It is accepted in some centres that K-type individuals are susceptible to malignant hyperthermia (MHS). In this paper, the K-type is shown not to correlate with the MH susceptible (MHS) status as accepted by the European MH group.
Ellis
F R
FR
Leeds Malignant Hyperthermia Investigation Unit, St James's University Hospital, Leeds.
Halsall
P J
PJ
Hopkins
P M
PM
D002110:Caffeine / Q000494:pharmacology; D046508:Culture Techniques; D004198:Disease Susceptibility; D006221:Halothane / Q000494:pharmacology; D006801:Humans; D008305:Malignant Hyperthermia / Q000175:diagnosis* / Q000235:genetics; D009119:Muscle Contraction / Q000187:drug effects; D010641:Phenotype
D002110:Caffeine; D006221:Halothane