Clotest (rapid urease test) in the diagnosis of Helicobacter pylori infection.
Over a period of 3 months, 85 patients who underwent gastroscopy had antral biopsy taken for Clotest, histology and/or culture for Helicobacter pylori (HP). The sensitivity and specificity of Clotest were found to be 77% and 96% respectively with negative predictive value of 63% and positive predictive value of 98%. Ninety-two percent of the positive Clotests were positive within 20 minutes, thus giving rapid result. Therefore, Clotest is a rapid, sensitive and highly specific test for HP infection. A high correlation between HP infection and chronic gastritis was noted and the prevalence of HP infection in patients with duodenal ulcer (90%) was higher than that of gastric ulcer (64%) or non-ulcer group (65%).
Ng
T M
TM
Department of Medicine, Toa Payoh Hospital Pte Ltd, Singapore.
Fock
K M
KM
Ho
J
J
Tan
A L
AL
Chia
S C
SC
Yap
C K
CK
Chew
C N
CN
Chee
E N
EN
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005753:Gastric Mucosa / Q000201:enzymology; D005756:Gastritis / Q000175:diagnosis / Q000382:microbiology*; D016481:Helicobacter Infections / Q000175:diagnosis*; D016480:Helicobacter pylori / Q000201:enzymology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011933:Reagent Kits, Diagnostic; D014510:Urease / Q000032:analysis*
D011933:Reagent Kits, Diagnostic; D014510:Urease