Amphetamine-antagonistic property of 4-phenyltetrahydroisoquinoline: effect on noradrenaline release in spinal cord slices.
The amphetamine-related compounds methamphetamine, phenylethylamine and nomifensine increased the K(+)-evoked release of endogenous noradrenaline from rat spinal cord slices. 4-Phenyl-1,2,3,4-tetrahydroisoquinoline (4PTIQ), which alone did not affect the K(+)-evoked release of noradrenaline, inhibited the noradrenaline-releasing effects of methamphetamine, phenylethylamine and nomifensine. 4PTIQ revealed a weak noradrenaline-uptake inhibitory effect, and the effect was weaker than those of desipramine and nomifensine. These results showed that 4PTIQ is an antagonist against the amine-releasing effects of amphetamines.
Satoh
M
M
Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Ohta
S
S
Nagao
T
T
Hirobe
M
M
Fukuda
H
H
Ono
H
H
D000661:Amphetamine / Q000037:antagonists & inhibitors*; D000818:Animals; D003891:Desipramine / Q000494:pharmacology; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D009627:Nomifensine / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism*; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism; D044005:Tetrahydroisoquinolines
D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; D009627:Nomifensine; C074266:4-phenyl-1,2,3,4-tetrahydroisoquinoline; D000661:Amphetamine; D011188:Potassium; D003891:Desipramine; D009638:Norepinephrine