Rational use of antiepileptic drug levels.
Antiepileptic drug (AED) levels are obtained frequently in clinical practice, but their complex relation to seizures or drug toxicity often makes interpretation of the results difficult. Research studies have not always taken into account clinical, as well as pharmacokinetic and pharmacodynamic, factors which may influence the drug level-effect relationship. AED levels should be drawn at an appropriate time in relation to drug ingestion and clinical symptoms. Systematic investigations in selected patients, during which several levels are obtained, may be more rewarding than routine measurements in a large clinic population.
Theodore
W H
WH
Clinical Epilepsy Section, National Institutes of Health, Bethesda, MD 20892.
D002220:Carbamazepine / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006207:Half-Life; D006801:Humans; D010634:Phenobarbital / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D010672:Phenytoin / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D012640:Seizures / Q000097:blood / Q000517:prevention & control*; D014635:Valproic Acid / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*
D002220:Carbamazepine; D014635:Valproic Acid; D010672:Phenytoin; D010634:Phenobarbital