title: [Protection from virulent Salmonella groups B and D after the peroral immunization of chicks with a hybrid of Salmonella typhimurium and Salmonella dublin].
abstract: Chickens over 10 days old, infected orally with virulent salmonellae, were found to remain alive. Histologic investigation showed the development of mild enteritis and more pronounced, lasting for more than two weeks, inflammation of the cecum, dissemination and focal lesions in the liver (granulomas, necrosis). In experiments on the oral immunization of 3-day old chickens the bivalent hybrid of S. typhimurium vaccine strain 274 and S. dublin induced only pronounced blast transformation in lymphatic follicles of the cecum, hyperplasia of activated macrophages and formation of granulomas from these macrophages and lymphocytes. After oral challenge of the immunized chickens with virulent salmonellae of group B (S. typhimurium) and group D (S. enteritidis, S. gallinarum-pullorum) the chickens exhibited sharply pronounced protection against adhesion, colonization and invasion, and a few penetrating bacteria were rapidly destroyed by immune macrophages. Hybrid strain 274/O9 proved to be suitable for use as oral bivalent vaccine against salmonellosis in chickens.
authors: Iu E
authors: IuE
authors: Polotskiĭ
authors: V E
authors: VE
authors: Efremov
authors: V M
authors: VM
authors: Bondarenko
authors: V A
authors: VA
authors: Kuz'min
authors: G V
authors: GV
authors: Smirnova
authors: Iu M
authors: IuM
authors: Romanova
authors: A G
authors: AG
authors: Belov
authors: P N
authors: PN
authors: Maksimov
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001422:Bacterial Adhesion; D001428:Bacterial Vaccines / Q000276:immunology*; D002645:Chickens; D003433:Crosses, Genetic; D007114:Immunization / Q000379:methods*; D011201:Poultry Diseases / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D012481:Salmonella Infections, Animal / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D012477:Salmonella enteritidis / Q000472:pathogenicity*; D012486:Salmonella typhimurium / Q000276:immunology* / Q000472:pathogenicity*; D013997:Time Factors; D014614:Vaccines, Synthetic / Q000276:immunology; D014774:Virulence
chemical_list: D001428:Bacterial Vaccines; D014614:Vaccines, Synthetic
vernacular_title: Zashchita ot virulentnykh sal'monell grupp B i D posle peroral'noĭ immunizatsii tsypliat gibridom Salmonella typhimurium i Salmonella dublin.