Creutzfeldt-Jakob disease in a recipient of human pituitary-derived gonadotrophin: a second case.
A 44 year old female presented with a progressive cerebellar disturbance approximately 13 years after receiving human pituitary derived gonadotrophin injections as a treatment for infertility. The patient died approximately nine months later. Creutzfeldt-Jakob disease was confirmed at necropsy. This is the second reported case of Creutzfeldt-Jakob disease in a recipient of human derived gonadotrophin.
Cochius
J I
JI
Department of Neurology, Radcliffe Infirmary, Oxford, UK.
Hyman
N
N
Esiri
M M
MM
D000328:Adult; D001344:Autopsy; D002531:Cerebellum / Q000648:ultrastructure; D007562:Creutzfeldt-Jakob Syndrome / Q000139:chemically induced*; D004831:Epilepsies, Myoclonic / Q000139:chemically induced; D005260:Female; D006065:Gonadotropins, Pituitary / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*; D013702:Temporal Lobe / Q000648:ultrastructure
D006065:Gonadotropins, Pituitary