[The effect of a single dose of Bisoprolol on changes in blood pressure and hemodymic indicators in patients with mild hypertension during loading].
The authors administered to 10 patients with mild hypertension a single dose of 10 mg bisoprolol (CONCOR-Merck) during bioimpedance control of changes of the cardiac index and peripheral vascular resistance during an isometric load after an interval of 3 and 24 hours following administration of the drug. In all patients administration of the drug led during the third hour to a statistically significant drop of the blood pressure after a load. Twenty-four hours after administration the drop was no longer statistically significant. In patients with a high cardiac index (group A, n = 6) the decline of blood pressure was due to a blocked increment of the cardiac output and a slight block of the peripheral vascular resistance. In the group with a low cardiac index and high peripheral vascular resistance (group B, n = 3) the drop of the blood pressure was less marked than in group A and it was due only to the blocked increment of the cardiac output. The increment of the peripheral vascular resistance was not influenced by the preparation. Bisoprolol did not affect the left ventricular systolic function.
Oral
I
I
I. interní klinika FN Olomouc.
Vareka
I
I
Marek
D
D
D017298:Bisoprolol / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D005080:Exercise Test; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008875:Middle Aged
D017298:Bisoprolol
Vliv jednorázového podání Bisoprololu na zmĕnu krevního tlaku a hemodynamických ukazatelů u nemocných s mírnou hypertenzí pri zátĕzi.