[Brain scintigraphy (SPECT) with thallium-201 in primary brain tumors].
We evaluated the role of thallium-201 single-photon emission-computed tomography (SPECT) in diagnosis, differential diagnosis and follow-up of 33 patients with primary brain tumors. 27 of 33 lesions were detectable by Tl-201 SPECT because only two of eight low-grade (grade 1 and 2) astrocytomas showed Tl-201 accumulation up to a tumor to nontumor ratio of 2.6. High grade (grade 3 and 4) astrocytomas showed Tl-201 accumulation in the range of 2.2 up to 13.0 and were different from low-grade astrocytomas. Noninvasive grading of astrocytomas is therefore possible, whereas differential diagnosis of oligodendrogliomas and astrocytomas or meningiomas was not possible with Tl-201. In the follow-up of six patients, we could demonstrate, that tumor progression is correlated with increasing and tumor regression with decreasing Tl-201 accumulations. This functional changing proceed morphological findings in CT. But vanishing of Tl-201 accumulation during therapy does not mean vanishing of tumor as could be demonstrated by follow-up.
Barzen
G
G
Strahlenklinik mit Poliklinik, Klinikum Rudolf-Virchow, Charlottenburg, Freien Universität Berlin.
Schubert
C
C
Richter
W
W
Calder
D
D
Bärwald
M
M
Eichstädt
H
H
Felix
R
R
D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000628:therapy; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D013794:Thallium Radioisotopes; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods* / Q000706:statistics & numerical data; D014057:Tomography, X-Ray Computed
D013794:Thallium Radioisotopes
Hirnszintigraphie (SPECT) mit Thallium 201 bei primären Hirntumoren.