[Cerebrospinal fluid methotrexate level in children treated with medium-high and high doses of the drug].
Concentrations of MTX were determined in the cerebrospinal fluid (csf) and serum after intravenous infusion of MTX at intermediate dose (0.5-1.0 g/m2) and at high dose (5.0 g/m2) to 20 children (33 infusions) with ALL/NHL. The cytotoxic concentrations of MTX in csf (> 1.0 microM/l) were reached in half of the cases after the infusion of MTX at intermediate dose and in all patients after the infusion of 5.0 g/m2. Great inpatient and interpatient variations of MTX concentrations in csf were observed. No statistically significant difference was found between mean systemic clearance of MTX in patients with MTXcsf concentrations > 1.0 microM/l and < 1.0 microM/l after infusion of MTX at intermediate dose.
Wysocki
M
M
Katedry i I Kliniki Chorób Dzieci A.M., Bydgoszczy.
Balcar-Boroń
A
A
Krzyzanowski
M
M
Szadujkis-Szadurski
L
L
Ozyński
T
T
Nowaczyk-Michalak
A
A
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D007262:Infusions, Intravenous; D008228:Lymphoma, Non-Hodgkin / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D008727:Methotrexate / Q000008:administration & dosage / Q000134:cerebrospinal fluid*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D013997:Time Factors
D008727:Methotrexate
Stezenie metotreksatu w płynie mózgowo-rdzeniowym u dzieci leczonych średnio duzymi i duzymi dawkami leku.