[Cholesterol and phospholipids in high density lipoproteins and their subfractions in a population in its second decade of life. The Burgos study].
Decreased levels of high-density lipoproteins (HDL) are related to a risk of ischaemic heart disease and are measured as HDL-cholesterol (HDLc), whereas little attention has been paid to HDL-phospholipids (HDLph). Regarding HDL subfractions (HDL2, HDL3) and risk of ischaemic heart disease, there are few studies in the literature and these are contradictory, especially those performed in subjects that were in their second decade of life. This study consisted of 322 healthy volunteers between 11 and 19 years of age. The HDL fractions and HDL3 subfractions were separated by precipitation with polyethylene glycol at defined pH and concentration. Concentrations of cholesterol and triglycerides were measured by enzymatic methods, except for HDL2c and HDL2ph, which were calculated by subtraction. Forty-two percent of the children with parental history of ischaemic heart disease, but only 26% of the children without parental history of heart disease, exhibited HDL3ph levels lower than 0.95 mmol/l (74 mg/dl). Levels of HDLc, HDL3c and HDL2c are relatively constant in girls after puberty and levels of HDLph and HDL3ph are increased; levels of HDLph are relatively constant in boys after puberty while levels of HDLc, HDL3c and HDL2c are decreased. Our results suggest that serum levels of HDL3ph are potential markers for a risk of ischaemic heart disease, together with other more classic risk factors.
Jover Sanz
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E
Servicio de Medicina Interna, Hospital Clínico Universitario, Valladolid.
Vella Ramírez
J C
JC
D000293:Adolescent; D000328:Adult; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000235:genetics; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D017202:Myocardial Ischemia / Q000097:blood*; D010743:Phospholipids / Q000097:blood*; D011627:Puberty; D012307:Risk Factors; D013030:Spain
D008076:Cholesterol, HDL; D008075:Lipoproteins, HDL; D010743:Phospholipids
Colesterol y fosfolípidos en lipoproteínas de alta densidad y sus subfracciones en una población en la segunda década de la vida. Estudio de Burgos.