title: GM-CSF, IL-3 and IL-5: cross-competition on human haemopoietic cells.
abstract: The biological properties of GM-CSF, IL-3 and IL-5 are multiple; initially described as haemopoietic growth factors, they also regulate inflammation, allergic reactions and cell adherence. The receptors for these three cytokines share a common component which may play a key role in their biological activity. This review describes the potential roles of GM-CSF, IL-3 and IL-5 in inflammation and discusses approaches to modulate their function.
authors: Hanson Centre for Cancer Research, Institute of Medical & Veterinary Science, Adelaide, Australia.
authors: A F
authors: AF
authors: Lopez
authors: M J
authors: MJ
authors: Elliott
authors: J
authors: J
authors: Woodcock
authors: M A
authors: MA
authors: Vadas
mesh_terms: D001667:Binding, Competitive; D002462:Cell Membrane / Q000378:metabolism; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000502:physiology*; D006410:Hematopoiesis; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D007377:Interleukin-3 / Q000502:physiology*; D015848:Interleukin-5 / Q000502:physiology*; D007962:Leukocytes / Q000502:physiology*; D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / Q000502:physiology*; D011971:Receptors, Immunologic / Q000502:physiology*; D018123:Receptors, Interleukin; D016185:Receptors, Interleukin-3 / Q000502:physiology*; D053649:Receptors, Interleukin-5; D015398:Signal Transduction
chemical_list: D007377:Interleukin-3; D015848:Interleukin-5; D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; D011971:Receptors, Immunologic; D018123:Receptors, Interleukin; D016185:Receptors, Interleukin-3; D053649:Receptors, Interleukin-5; D016178:Granulocyte-Macrophage Colony-Stimulating Factor