Dietary restriction in nonhuman primates: progress report on the NIA study.
Rhesus and squirrel monkeys have been fed a semisynthetic diet at approximately ad libitum or 30% reduced levels for 3.5 (rhesus group 2) to 4.5 (rhesus group 1 and squirrel) years. Animals have maintained excellent health status as determined by physical examinations, hematology, and blood chemistry. While relative rates of body weight gain in restricted group 1 rhesus and squirrel monkeys have been markedly reduced, DR effects on crown-rump length (body height) have been variable. In addition, numerous physiological and biochemical parameters have been measured, and several exhibit significant cross-sectional age effects. Interestingly, several of these also exhibit possible species and genotype (group 1 and 2 rhesus) differences. A number of physiological parameters are emerging that might be altered by DR; however, further explanation of these effects awaits more extensive and detailed analyses.
Lane
M A
MA
Molecular Physiology and Genetics Section, National Institute on Aging, National Institutes of Health, Francis Scott Key Medical Center, Baltimore, Maryland 21224.
Ingram
D K
DK
Cutler
R G
RG
Knapka
J J
JJ
Barnard
D E
DE
Roth
G S
GS
D000375:Aging / Q000378:metabolism / Q000502:physiology*; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001827:Body Height; D001835:Body Weight; D004032:Diet; D008253:Macaca mulatta / Q000502:physiology; D008297:Male; D009316:National Institutes of Health (U.S.); D012453:Saimiri / Q000502:physiology; D014481:United States
D000469:Alkaline Phosphatase