Oral mesna: a review.
Oral administration of mesna can facilitate outpatient ifosfamide therapy. Blood and urinary mesna concentrations are more steady and prolonged after oral delivery compared with after intravenous delivery. The incidence of hematuria observed during partial oral mesna therapy is no greater than that during intravenous mesna therapy. The pharmacology, pharmacokinetics, efficacy, safety, and reported schedules of administration are reviewed.
Goren
M P
MP
Department of Pathology and Laboratory Medicine, St Jude Children's Research Hospital, University of Tennessee, Memphis 38101-0318.
D000284:Administration, Oral; D000818:Animals; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage*; D015080:Mesna / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology
D015080:Mesna; D007069:Ifosfamide