Vitamin E inhibits protein oxidation in skeletal muscle of resting and exercised rats.
It is well known that exercise induces lipid peroxidation in skeletal muscle and that vitamin E prevents exercise-induced lipid damage. In this study we show for the first time, an increase in protein oxidation in skeletal muscle after a single bout of exercise, related to an exercise-induced decrease in lipophilic antioxidants, and substantial protection against both resting and exercise-induced protein oxidation by supplementation with various isomers (alpha-tocopherol, alpha-tocotrienol) of vitamin E.
Reznick
A Z
AZ
Department of Morphological Sciences, Technion Faculty of Medicine, Haifa, Israel.
Witt
E
E
Matsumoto
M
M
Packer
L
L
D000818:Animals; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology; D005260:Female; D009132:Muscles / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D009928:Organ Specificity; D010084:Oxidation-Reduction; D000073878:Palm Oil; D005082:Physical Exertion; D010938:Plant Oils / Q000494:pharmacology; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000378:metabolism; D014810:Vitamin E / Q000378:metabolism / Q000494:pharmacology*
D004042:Dietary Fats, Unsaturated; D010938:Plant Oils; D011506:Proteins; D014451:Ubiquinone; D014810:Vitamin E; D000073878:Palm Oil; C003741:ubiquinol