[Pharmacology of selegiline (recent considerations)].
The nigrostriatal system, where dopaminergic neuron activity dominates, plays and important role in control of motoric and psychic functions. Selegiline with its neurochemical activity ie. MAO-B enzyme and dopamine uptake inhibition is able to restore or improve the deteriorated function of that system. Selegiline can hinder the uptake of tyramine into the peripheral sympathetic nerve endings, so cheese effect, which is a characteristic and dangerous side effect induced by MAO-A inhibitors, does not occur. Selegiline can potentiate the learning activity of PEA in rats, these effect may be connected with increased dopamine turnover in the striatum. In pathological conditions dopamine can be replaced by L-dopa, so it has a fundamental role in the improvement of dopaminergic functions. According to neurochemical activity selegiline takes a prominent role in the extension and improvement of L-dopa therapy. The neuroprotective effect of selegiline is multiple, with the inhibition of MAO-B it can stop the production of neurotoxin MPP+ (arising from MPTP) and its uptake into the nerve endings respectively. In chronic treatment with Selegiline SOD activity increases in rats, as a consequence the level of free oxygen radicals and toxic metabolites can be diminished. Chronic treatment with selegiline does not influence the activity of young animals, but improves sexual activity and learning capacity and enlarges life expectancy of old rats. These experiments verified its positive activity on the nigrostriatal system and give a good chance for geriatric usage. In longtime treatments dependency was not stated.
Tardos
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L
Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt., Budapest.
Jánváriné Kanyó
E
E
D000367:Age Factors; D000818:Animals; D004305:Dose-Response Relationship, Drug; D051379:Mice; D014179:Neurotransmitter Uptake Inhibitors / Q000494:pharmacology; D051381:Rats; D012642:Selegiline / Q000494:pharmacology*; D012726:Sexual Behavior, Animal / Q000187:drug effects; D014439:Tyramine / Q000502:physiology
D014179:Neurotransmitter Uptake Inhibitors; D012642:Selegiline; D014439:Tyramine
A selegilin farmakológiája (újabb szempontok).