title: Nationwide spread of Klebsiella oxytoca K55 in Swedish neonatal special care wards.
abstract: In a nationwide survey of invasive bacterial infections in Swedish neonates, 36% of Klebsiella spp. were Klebsiella oxytoca serotype K55. This unexpectedly high proportion of K55 infections was due to clusters of infection in neonatal special care wards, and at first seemed attributable to nosocomial spread of a K. oxytoca strain of high virulence. Factors predisposing infants to infection were, however, found irrespective of whether the infecting strain was of serotype K55 or not. Additionally, the prevalence rates of a potential virulence factor, siderophore production, were similar among the two groups of strains. During the same period of time a K. oxytoca K55 with similar biochemical phenotype and drug resistance pattern was found to be spread among the neonates in 12 of 22 neonatal wards in Sweden. The increased proportion of invasive neonatal K. oxytoca K55 infections thus seemed to reflect a high rate of colonization rather than an increased virulence of the K55 strain.
authors: Department of Paediatrics, St. Göran's Children's Hospital, Stockholm, Sweden.
authors: K
authors: K
authors: Tullus
authors: B
authors: B
authors: Ayling-Smith
authors: I
authors: I
authors: Kühn
authors: W
authors: W
authors: Rabsch
authors: R
authors: R
authors: Reissbrodt
authors: L G
authors: LG
authors: Burman
mesh_terms: D004196:Disease Outbreaks; D004352:Drug Resistance, Microbial; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000453:epidemiology / Q000382:microbiology*; D007363:Intensive Care Units, Neonatal; D007709:Klebsiella / Q000145:classification; D007710:Klebsiella Infections / Q000453:epidemiology*; D008297:Male; D012703:Serotyping; D013548:Sweden