title: The effect of long-term exposure to phosphamidon on the ruminal microorganisms and circulating carboxylesterase of Bubalus bubalis.
abstract: The effect of long-term exposure to the organophosphate insecticide phosphamidon on the ruminal microorganisms and serum carboxylesterase of buffalo calves was investigated. Oral administration of phosphamidon in doses of 0.25 and 0.5 mg/kg per day for 120 days caused significant inactivation of carboxylesterase activity (16-32%) without eliciting any intoxicating signs apart from mild intermittent diarrhoea in the animals receiving the higher dose. The higher dose also produced a significant reduction in the total number of rumen protozoa (16-24%). However, the insecticide had no discernible effect on the total bacterial count or pH of the rumen liquor.
authors: Department of Pharmacology, Bangladesh Agricultural University, India.
authors: M A
authors: MA
authors: Awal
authors: J K
authors: JK
authors: Malik
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001421:Bacteria, Anaerobic / Q000187:drug effects; D002020:Buffaloes / Q000097:blood / Q000382:microbiology* / Q000469:parasitology*; D043182:Carboxylesterase; D002265:Carboxylic Ester Hydrolases / Q000097:blood / Q000187:drug effects*; D056890:Eukaryota / Q000187:drug effects; D008297:Male; D010707:Phosphamidon / Q000494:pharmacology*; D012417:Rumen / Q000382:microbiology* / Q000469:parasitology*
chemical_list: D010707:Phosphamidon; D002265:Carboxylic Ester Hydrolases; D043182:Carboxylesterase