[Value of thymidine kinase in the prediction of response to treatment by chemotherapy or hormone therapy in breast cancer].
Thymidine kinase (TK) was assayed in the cytosol of 210 primary breast cancers to assess its predictive value for response to first line chemotherapy and hormonotherapy. We performed correlations between TK and the other prognosis factors of breast cancer. TK activity is correlated with SBR grading and estrogen receptors. It has a low predictive value for response to chemotherapy and is not useful for hormonotherapy.
Bennini
N
N
Fondation Bergonié, Bordeaux, France.
Mauriac
L
L
Wafflart
J
J
Bonichon
F
F
Durand
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000201:enzymology* / Q000473:pathology; D003600:Cytosol / Q000201:enzymology; D005260:Female; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D013629:Tamoxifen / Q000627:therapeutic use*; D013937:Thymidine Kinase / Q000378:metabolism*
D013629:Tamoxifen; D013937:Thymidine Kinase
Intérêt de la thymidine kinase dans la prédiction de la réponse à un traitement par chimiothérapie ou hormonothérapie dans le cancer du sein.