Acute nonlymphocytic leukemia after treatment of systemic lupus erythematosus with immunosuppressive agents.
We describe a case of acute nonlymphocytic leukemia with inversion of chromosome 16 in a patient with systemic lupus erythematosus treated with immunosuppressive agents including azathioprine and cyclophosphamide. Although the leukemia may have been caused by other factors, it is worth noting the potential association of this malignancy with immunosuppressive therapy.
Vasquez
S
S
Harold C. Simmons Arthritis Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235.
Kavanaugh
A F
AF
Schneider
N R
NR
Wacholtz
M C
MC
Lipsky
P E
PE
D000328:Adult; D001379:Azathioprine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D002885:Chromosomes, Human, Pair 16; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D007275:Injections, Intravenous; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced* / Q000235:genetics; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy*
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D001379:Azathioprine