Clinical experience with tissue plasminogen activator stored at -20 degrees C.
We developed a new dilution technique that allows tissue plasminogen activator (t-PA) to be stored at -20 degrees C, as opposed to the -70 degrees C recommended by the United States manufacturer (Genentech Inc). Following tests that showed neither loss in activity nor microbiological contamination, we clinically proved the efficacy of t-PA stored at -20 degrees C in 10 cases.
Grewing
R
R
Department of Ophthalmology, Bundesknappschaft Sulzbach/Saar, Germany.
Mester
U
U
Löw
M
M
D015925:Cryopreservation / Q000379:methods; D004356:Drug Storage / Q000379:methods; D005128:Eye Diseases / Q000601:surgery; D005337:Fibrin / Q000378:metabolism; D006801:Humans; D008828:Microbiological Techniques; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
D005337:Fibrin; D010959:Tissue Plasminogen Activator