title: [Epidemiologic study on the effectiveness and safety of dihydroergocristine in impaired memory and behavioral functions in aged humans].
abstract: Aim of the study was to assess the activity of dihydroergocristine (DHEC, CAS 17479-19-5) in aged patients with impaired cognitive function. Twenty-five university hospital centres and 250 physicians participated in the study. 2,600 patients (1,104 males and 1,496 females, age range 50-80 years) were admitted to the study. Each patient was administered 6 mg/d DHEC for 120 days. Clinical evaluation was made through the SCAG Rating Scale registered at basal time, after 60 and 120 days. Responsivity to treatment was considered high when the final score was reduced by 30% and none if less than 10%. Analysis of results demonstrated that at the end of the study responsivity was high in 73% of cases, moderate in 20.4% and absent in 6.5%. Tolerability was very good as side effects were reported only in 3.16% of patients. Most frequent side effects were: nausea (1.23%), gastralgia (1.11%), headache (0.29%), hypotension (0.12%), vertigo (0.12%) and rash (0.08%). Drop-outs for gastralgia were reported only in 0.53% of the patients.
authors: Neurologisch-geriatrische Universitäts-Krankenhaus-Zentren, Poli Industria Chimica S.p.A., Rozzano, Mailand, Italien.
authors: G
authors: G
authors: Abate
authors: F
authors: F
authors: Angeleri
authors: L
authors: L
authors: Bartorelli
authors: L
authors: L
authors: Battistin
authors: B
authors: B
authors: Bergamasco
authors: S
authors: S
authors: Bertolini
authors: A
authors: A
authors: Bulfoni
authors: A
authors: A
authors: Capurso
authors: G
authors: G
authors: Cazzato
authors: G
authors: G
authors: Coccagna
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001519:Behavior / Q000187:drug effects*; D004088:Dihydroergotoxine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000188:drug therapy* / Q000523:psychology; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales
chemical_list: D004088:Dihydroergotoxine
vernacular_title: Epidemiologische Studie zur Wirksamkeit und Verträglichkeit von Dihydroergocristin bei Verschlechterung der Gedächtnis- und der Verhaltensfunktionen beim älteren Menschen.