[The effect of anaprilin on the reaction of the sympathetic-adrenal system to graded physical loading in healthy subjects and patients with ischemic heart disease].
The specific features of responses of the sympathoadrenal system during its activation by graded exercise (E), including that along with anaprilin induced blockade of beta-adrenoceptors, were determined from the urinary excretion of norepinephrine, epinephrine, dopamine, and dioxyphenylalanine in 54 healthy males and 22 patients with postinfarction cardiosclerosis concurrent with Functional Class I-II angina pectoris on effort. E caused hyperreactivity of the sympathoadrenal system, as appeared as significantly greater increases in the levels of catecholamines and their precursors in the patients than in the healthy persons. A single anaprilin dose of 40 mg abolished the responsiveness to exercise and improved its tolerance. The revealed features of sympathoadrenal responsiveness to exercise with and without anaprilin suggest that the patients with coronary heart disease have sympathoadrenal dysfunction, which shows one of the possible mechanisms responsible for the cardioprotective effect of beta-adrenoblockers in this disease.
Sokolov
E I
EI
Zaev
A P
AP
Burmantova
N P
NP
Khovanskaia
T P
TP
Petrin
S V
SV
Filonov
V K
VK
Tebloev
K I
KI
Pereponov
Iu P
IuP
D000311:Adrenal Glands / Q000187:drug effects* / Q000502:physiology; D000328:Adult; D000787:Angina Pectoris / Q000188:drug therapy / Q000503:physiopathology / Q000652:urine; D002395:Catecholamines / Q000652:urine; D005080:Exercise Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000503:physiopathology / Q000652:urine; D005082:Physical Exertion / Q000187:drug effects* / Q000502:physiology; D011433:Propranolol / Q000494:pharmacology* / Q000627:therapeutic use; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
D002395:Catecholamines; D011433:Propranolol
Vliianie anaprilina na reaktsiiu simpatiko-adrenalovoĭ sistemy pri dozirovannoĭ fizicheskoĭ nagruzke u zdorovoykh liudeĭ i bol'nykh ishemicheskoĭ bolezn'iu serdtsa.