title: Effects of a constant dose rate of terbutaline on circadian peak expiratory flow, heart rate and systolic arterial pressure in patients with asthma exacerbation.
abstract: The purpose of this study was to investigate the effect of a constant infusion rate of terbutaline on circadian bronchial peak expiratory flow rate (PEFR), heart rate and arterial pressure in patients with asthma exacerbation. Fifteen hospitalized asthmatic patients (6 females and 9 males, mean age 43.3 years, mean weight 67.0 kg) were included in this study. In order to reach the desired plasma concentrations of terbutaline immediately, a pharmacokinetic simulation was done. Based on the predicted values thus obtained, an initial 5-min bolus dose of 2.94 micrograms/kg was given to all patients at 7 a.m., i.e. at the beginning of the study. Over the following 24 h (7 a.m. to 7 a.m.), 33 micrograms/kg of terbutaline was infused intravenously at a constant rate with an electric pump. Since severe acute asthma requires corticosteroids, a 40-mg injection of methylprednisolone was given to all patients at 7 a.m. PEFR, heart rate, systolic arterial pressure, side effects and plasma terbutaline levels were recorded at 7 and 10 a.m., 1, 4, 7 and 11 p.m., and 3 and 7 a.m. the following morning. Terbutaline had a significant favorable effect on asthma exacerbation but no circadian rhythm was found in PEFR. Although terbutaline was infused at a constant rate, plasma levels depended on circadian variations.
authors: Service de Pneumologie-Allergologie, CHU NORD, Marseille, France.
authors: F
authors: F
authors: Philip-Joet
authors: B
authors: B
authors: Bruguerolle
authors: F
authors: F
authors: Lagier
authors: F
authors: F
authors: Pierson
authors: M
authors: M
authors: Reynaud
authors: M
authors: M
authors: Leonardelli
authors: J P
authors: JP
authors: Orlando
authors: D
authors: D
authors: Vervloet
authors: A
authors: A
authors: Arnaud
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology*; D001794:Blood Pressure / Q000187:drug effects; D002940:Circadian Rhythm / Q000187:drug effects; D004334:Drug Administration Schedule; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D010366:Peak Expiratory Flow Rate / Q000187:drug effects; D013599:Systole / Q000187:drug effects; D013726:Terbutaline / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*
chemical_list: D013726:Terbutaline