title: Perioperative factors associated with septic arthritis after arthroplasty. Prospective multicenter study of 362 knee and 2,651 hip operations.
abstract: Perioperative factors associated with late septic arthritis after knee and hip arthroplasties were prospectively investigated. All patients received a short course of perioperative cefuroxime. After a follow-up of 1 year, septic arthritis was diagnosed in 9/362 patients (2.5 percent) after knee arthroplasty and in 17/2651 patients (0.64 percent) after hip arthroplasty. For the knee, factors associated with septic arthritis after arthroplasty were rheumatoid arthritis, wound infection, an unhealed wound, and a painful, limited knee function at discharge from the hospital. For the hip, corresponding risk factors were diabetes, failed fracture osteosynthesis, a breakdown of sterility during operation, wound infection, postoperative urinary tract infection, and an unhealed wound at discharge from the hospital or a difficult rehabilitation course. Reoperation after knee and hip arthroplasty was also clearly associated with a higher incidence of septic arthritis.
authors: Department of Orthopedics, University Hospital Nijmegen, The Netherlands.
authors: A B
authors: AB
authors: Wymenga
authors: J R
authors: JR
authors: van Horn
authors: A
authors: A
authors: Theeuwes
authors: H L
authors: HL
authors: Muytjens
authors: T J
authors: TJ
authors: Slooff
mesh_terms: D001170:Arthritis, Infectious / Q000209:etiology*; D001172:Arthritis, Rheumatoid / Q000150:complications; D002444:Cefuroxime / Q000008:administration & dosage*; D048909:Diabetes Complications; D005500:Follow-Up Studies; D050723:Fractures, Bone / Q000150:complications; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D007720:Knee Prosthesis / Q000009:adverse effects*; D015999:Multivariate Analysis; D011446:Prospective Studies; D012086:Reoperation; D012307:Risk Factors; D013211:Staphylococcus aureus / Q000302:isolation & purification; D013530:Surgical Wound Infection / Q000209:etiology; D014552:Urinary Tract Infections / Q000150:complications; D014945:Wound Healing
chemical_list: D002444:Cefuroxime