Effects of short-term treatment with corticosteroids and indomethacin on bone healing. A mechanical study of osteotomies in rats.
We studied the effects of short-term therapy with methylprednisolone and indomethacin on healing of intramedullary pinned osteotomies of the femur in rats. When the osteotomy was complete and healing occurred under unstable conditions with callus formation, indomethacin inhibited healing when estimated by mechanical tests of bending moment, energy expenditure before refracture, and bending rigidity 6 weeks after surgery. No inhibitory effects were seen following corticosteroid treatment. When the osteotomy was incomplete and healing occurred under stable conditions, similar tendencies were observed. Thus, short-term medication with indomethacin inhibits fracture healing. This was not the case with short-term methylprednisolone.
Høgevold
H E
HE
Department of Surgery, Ullevål University Hospital, Oslo, Norway.
Grøgaard
B
B
Reikerås
O
O
D000818:Animals; D001696:Biomechanical Phenomena; D004548:Elasticity / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects; D005269:Femur / Q000503:physiopathology / Q000601:surgery; D017102:Fracture Healing / Q000187:drug effects* / Q000502:physiology; D007213:Indomethacin / Q000627:therapeutic use*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D010027:Osteotomy; D051381:Rats; D017208:Rats, Wistar
D008775:Methylprednisolone; D007213:Indomethacin