Hemolytic anemia and thrombocytopenia induced by cyanidanol.
Five patients who received cyanidanol for 4-36 months are presented. Three developed both hemolytic anemia and thrombocytopenia, while 2 had only thrombocytopenia. After suspending the drug the hematological values returned to normal in all of the patients. Drug-dependent platelet antibodies were detected in 4 of the 5 patients and cyanidanol-dependent red blood cell antibodies were present in 3. There are various mechanisms involved in the cyanidanol-induced immune cytopenias and, as in the present study, were sometimes simultaneously observed in the same patient.
Gandolfo
G M
GM
Department of Experimental Medicine, La Sapienza, University of Rome, Italy.
Girelli
G
G
Conti
L
L
Perrone
M P
MP
Arista
M C
MC
Damico
C
C
D000368:Aged; D000743:Anemia, Hemolytic / Q000139:chemically induced / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000139:chemically induced*; D001792:Blood Platelets / Q000276:immunology; D002392:Catechin / Q000009:adverse effects*; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D013921:Thrombocytopenia / Q000139:chemically induced / Q000276:immunology*
D001323:Autoantibodies; D007074:Immunoglobulin G; D002392:Catechin