title: Somatosensory regulation of regional hippocampal blood flow in anesthetized rats.
abstract: The effect of noxious or non-noxious mechanical stimulation of various cutaneous areas on cerebral blood flow in hippocampus was examined with laser Doppler flowmetry in urethane-anesthetized artificially-ventilated rats. Noxious mechanical stimulation (pinching) of the skin on the face, forepaw, chest, or hindpaw for 20s increased regional hippocampal blood flow (Hpc-BF) and systemic blood pressure, but non-noxious mechanical stimulation (brushing) had no such effect. After the spinal cord was transected at T1 level a forepaw pinch caused no change in blood pressure but still increased Hpc-BF. This suggests that cutaneous noxious stimulation can induce pressor-independent increases in Hpc-BF. The increase in Hpc-BF induced by a forepaw pinch in T1-transected rats was partially reduced by intravenous administration of mecamylamine (2 mg/kg), a nicotinic cholinergic receptor antagonist. Atropine (0.5 mg/kg), a muscarinic cholinergic antagonist was ineffective. These data indicate that the cholinergic vasodilative system is involved in the somatically-induced increase in Hpc-BF via activation of the nicotinic cholinergic receptors.
authors: Department of Autonomic Nervous System, Tokyo Metropolitan Institute of Gerontology, Japan.
authors: W H
authors: WH
authors: Cao
authors: A
authors: A
authors: Sato
authors: Y
authors: Y
authors: Sato
authors: W
authors: W
authors: Zhou
mesh_terms: D000818:Animals; D001285:Atropine / Q000008:administration & dosage / Q000494:pharmacology; D001794:Blood Pressure / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology*; D006624:Hippocampus / Q000098:blood supply*; D008297:Male; D008464:Mecamylamine / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011978:Receptors, Nicotinic / Q000502:physiology*; D012867:Skin / Q000294:innervation*
chemical_list: D011978:Receptors, Nicotinic; D008464:Mecamylamine; D001285:Atropine