A bioassay for mefloquine.
A bioassay method that allows for the estimation of serum concentrations of mefloquine is presented. Concentrations obtained by bioassay and high performance liquid chromatography showed a good correlation. This bioassay should be helpful in assessing prophylactic/treatment failures to mefloquine under field conditions.
Yeo
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AE
Army Malaria Research Unit, University of Sydney, Ingleburn, Australia.
Rieckmann
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KH
D000818:Animals; D001681:Biological Assay; D002851:Chromatography, High Pressure Liquid; D004311:Double-Blind Method; D015767:Mefloquine / Q000097:blood* / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects*
D015767:Mefloquine