[The pathogenesis and correction of disorders of the heart rhythm in the early post-resuscitation period].
The frequency and nature of heart rhythm disturbances have been studied in experiments on random-bred male rats who survived 4- and 6-min clinical deaths of acute blood loss. Using correlation analysis it has been shown that the leading pathogenetic arrhythmogenic factors are: catecholamine excess, as well as excess of free fatty acids, lipid peroxidation products, lactate and Ca-ATPase inhibition. The efficacy of preventive (gutimin, inderal, oxipiridin-6, isoptin) and therapeutic (carnozin, creatinphosphate) use of the drugs affecting pathogenetic mechanisms of heart arrhythmias and thus stabilizing bioelectrical heart activity in the early postresuscitation period has been observed.
Dolgikh
V T
VT
Rusakov
V V
VV
Korpacheva
O V
OV
Sudokova
A N
AN
Smolentseva
V N
VN
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000209:etiology* / Q000517:prevention & control; D008297:Male; D051381:Rats; D012151:Resuscitation; D013997:Time Factors
K patogenezu i korrektsii narusheniĭ ritma serdtsa v rannem postreanimatsionnom periode.