Delta sleep-inducing-peptide-like immunoreactivity (DSIP-LI) and delta sleep in schizophrenic volunteers.
Delta sleep-inducing-peptide (DSIP) has been reported to increase sleep in subjects with insomnia. The authors studied cerebrospinal fluid (CSF) DSIP-like immunoreactivity (DSIP-LI) in 15 drug-free male subjects with a DSM-IIIR diagnosis of schizophrenia. The subjects underwent a lumbar puncture and three nights of polysomnography. CSF DSIP-LI was significantly correlated with polysomnography the night before the LP: with stage 3 sleep (p = 0.05), stage 3 and delta (stages 3 + 4) sleep during the first nonrapid eye movement NREM period (p = 0.02 and p = 0.05, respectively) and the ratio of the first and second NREM period (p < 0.05), and negatively with stage 2% sleep (p < 0.05). Whether this first report of a potential relationship between CSF DSIP-LI and slow-wave sleep in man might be generalized to sleep in nonpsychiatric subjects awaits further study.
van Kammen
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Highland Drive VAMC, Pittsburgh, Pennsylvania 15206.
Widerlöv
E
E
Neylan
T C
TC
Ekman
R
R
Kelley
M E
ME
Mouton
A
A
Peters
J L
JL
D000328:Adult; D003700:Delta Rhythm; D003701:Delta Sleep-Inducing Peptide / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D017286:Polysomnography; D011863:Radioimmunoassay; D011930:Reaction Time / Q000502:physiology; D012559:Schizophrenia / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D012565:Schizophrenic Psychology; D012894:Sleep Stages / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology; D014851:Wakefulness
D003701:Delta Sleep-Inducing Peptide