Juvenile colloid milium: clinical, histological and ultrastructural features.
We report the clinical, histological and ultrastructural features of juvenile colloid milium affecting a brother and sister. In this rare condition, translucent papules develop on sun-exposed areas of skin, with onset in childhood. Histologically and ultrastructurally, the papules consist of amyloid-like material derived from epidermal keratonocytes. A review of the literature suggests a possible genetic abnormality that leads to sun-induced degeneration of keratinocytes.
Handfield-Jones
S E
SE
St. John's Dermatology Centre, St. Thomas' Hospital, London, England.
Atherton
D J
DJ
Black
M M
MM
Hashimoto
K
K
McKee
P H
PH
D000293:Adolescent; D000682:Amyloid / Q000032:analysis; D002648:Child; D003102:Colloids / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015603:Keratinocytes / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D012867:Skin / Q000737:chemistry* / Q000473:pathology / Q000648:ultrastructure; D012871:Skin Diseases / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D013472:Sunlight
D000682:Amyloid; D003102:Colloids