title: Effects of chlorothiazide on urinary excretion of calcium in clinically normal dogs.
abstract: Administration of thiazide diuretics has been recommended to prevent calcium oxalate urolith development in dogs. To evaluate the effects of thiazide diuretics in dogs, 24-hour urine excretion of calcium was measured in 6 clinically normal Beagles after administration of chlorothiazide (CTZ) for 2 weeks, administration of CTZ for 10 weeks, and administration of calcium carbonate and CTZ for 2 weeks. Compared with baseline values, 24-hour urine calcium excretion did not decrease after CTZ administration. When CTZ was given at a high dosage (130 mg/kg of body weight), urinary calcium excretion was significantly (P < 0.04) higher than baseline values. Based on these observations, we do not recommend CTZ for treatment or prevention of canine calcium oxalate urolithiasis.
authors: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul 55108.
authors: J P
authors: JP
authors: Lulich
authors: C A
authors: CA
authors: Osborne
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002118:Calcium / Q000097:blood / Q000652:urine*; D002119:Calcium Carbonate / Q000493:pharmacokinetics; D002740:Chlorothiazide / Q000494:pharmacology*; D004285:Dogs / Q000097:blood / Q000652:urine*; D004573:Electrolytes / Q000097:blood / Q000652:urine; D005260:Female
chemical_list: D004573:Electrolytes; D002740:Chlorothiazide; D002119:Calcium Carbonate; D002118:Calcium