Glucose tolerance and insulin secretion in spontaneously hyperthyroid cats.
Glucose tolerance and insulin secretion after administration of a glucose load were determined in 11 clinically normal cats and 15 cats with spontaneous hyperthyroidism. In six hyperthyroid cats, a glucose tolerance test was repeated after treatment with radioactive iodine (131I). All cats had similar baseline glucose concentrations. However, the cats with hyperthyroidism had a significantly decreased glucose clearance, which was worse after treatment. Hyperthyroidism also caused a marked increase in basal and glucose-stimulated insulin secretion, which was not improved with treatment. It is concluded that hyperthyroidism in cats may lead to long-lasting alterations of glucose tolerance and insulin secretion which may not be reversed by treatment.
Hoenig
M
M
Department of Physiology and Pharmacology and Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602.
Peterson
M E
ME
Ferguson
D C
DC
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002371:Cat Diseases / Q000378:metabolism* / Q000532:radiotherapy; D002415:Cats; D005260:Female; D005951:Glucose Tolerance Test / Q000662:veterinary; D006980:Hyperthyroidism / Q000378:metabolism / Q000532:radiotherapy / Q000662:veterinary*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D013974:Thyroxine / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D007457:Iodine Radioisotopes; D013974:Thyroxine