Modification of RBC properties by an autoantibody. Binding to RBC senescent antigen.
It has been reported that natural antibodies alter aging RBCs, so increasing their vulnerability for removal from the blood stream. Results presented indicate that binding of anti-Gal, a natural antibody, to erythrocytes increases RBC rigidity in terms of microviscosity and deformability. Removal of RBCs from circulation could, at least in part, depend on these alterations.
Gareau
R
R
Université du Québec à Trois-Rivières, Québec, Canada.
Brisson
G R
GR
Dubé
J
J
Caron
C
C
Longuy
V
V
D000936:Antigen-Antibody Complex; D000941:Antigens / Q000097:blood; D001323:Autoantibodies / Q000097:blood* / Q000302:isolation & purification; D002469:Cell Separation; D002846:Chromatography, Affinity; D002850:Chromatography, Gel; D004905:Erythrocyte Aging / Q000276:immunology*; D004907:Erythrocyte Deformability; D004912:Erythrocytes / Q000166:cytology / Q000276:immunology*; D005454:Fluorescence Polarization; D005690:Galactose / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000302:isolation & purification
D000936:Antigen-Antibody Complex; D000941:Antigens; D001323:Autoantibodies; D007074:Immunoglobulin G; D005690:Galactose