Structure and hepatoprotective activity of a biflavonoid from Canarium manii.
Canarium manii (Burseraceae) was chemically investigated and the presence of the biflavonoid agathisflavone is reported for the first time from this plant. Pharmacologically, this biflavonoid in doses 50.0 mg and 100.0 mg given orally exhibited dose-dependent hepatoprotective activity against experimentally-induced carbon tetrachloride-hepatotoxicity in rats and mice.
Anand
K K
KK
Department of Pharmacology, Regional Research Laboratory, Jammu-Tawi, India.
Gupta
V N
VN
Rangari
V
V
Singh
B
B
Chandan
B K
BK
D000818:Animals; D044946:Biflavonoids; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects*; D051379:Mice; D015394:Molecular Structure; D010944:Plants / Q000737:chemistry*; D051381:Rats
D044946:Biflavonoids; D005419:Flavonoids; C079168:agathisflavone