Synthesis of 7-oxo-7H-benzo[e]perimidine-4-carboxamides as potential antitumor drugs.
A series of 7-oxo-7H-benzo[e]perimidine-4-carboxamides (4a-f) was synthetized from the corresponding acid (3) and the suitable amines by the "mixed anhydride" method. The amide derivatives were tested for antitumor activity against P 388 leukemia "in vivo". Only the N-[2-(diethylamino)ethyl]-7-oxo-7H-benzo[e]perimidine-4-carboxa mid e (4b) shows borderline antineoplastic activity.
Antonini
I
I
Dipartimento di Scienze Chimiche, Università di Camerino, Italy.
Polucci
P
P
Cola
D
D
Filippo Palmieri
G
G
Martelli
S
S
D000818:Animals; D000880:Anthraquinones / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D008815:Mice, Inbred Strains; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000880:Anthraquinones; D000970:Antineoplastic Agents; D011720:Pyrazoles