The potentiating effect of KC-404 on prostacyclin-induced vasodilation in isolated human cerebral artery.
1. KC-404 (10(-9)-10(-6) g/ml) produced concentration-dependent relaxations in human middle cerebral arteries contracted with prostaglandin F2 alpha. 2. KC-404 (10(-8) and 10(-7) g/ml) has the ability to significantly potentiate prostaglandin I2-induced relaxations in human middle cerebral arteries. 3. KC-404, at least in low concentrations, may elicit human cerebral vasodilation predominantly by potentiating relaxant responses to prostaglandin I2 produced spontaneously in vascular wall. 4. KC-404 is expected to increase cerebral blood flow at least by dilation of major cerebral arteries, and this agent may be beneficial for the treatment of cerebrovascular disorders.
Onoue
H
H
Department of Neurosurgery, Jikei University School of Medicine, Tokyo, Japan.
Kaito
N
N
Tokudome
S
S
Irikura
T
T
Okada
K
K
Abe
T
T
Nakamura
N
N
D002536:Cerebral Arteries / Q000187:drug effects*; D002648:Child; D015237:Dinoprost / Q000494:pharmacology; D011464:Epoprostenol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007537:Isometric Contraction / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009126:Muscle Relaxation / Q000187:drug effects; D011725:Pyridines / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology*; D007212:Indolizines; D011720:Pyrazoles
D015237:Dinoprost; D011464:Epoprostenol; D011725:Pyridines; D014665:Vasodilator Agents; C038366:ibudilast; D007212:Indolizines; D011720:Pyrazoles