title: Visualization of extrastriatal dopamine D2 receptors in the human brain.
abstract: [123I]Epidepride, a potent and selective dopamine D2 radioligand, was administered to a 27 year old normal male volunteer. Single photon tomography revealed that peak striatal uptake occurred at 4 h after injection with a striatal:cerebellar ratio of 7.8 rising to over 100 at 18 h post injection. Uptake above the levels seen in cerebellum was also noted in the thalamus, pituitary, hypothalamus and temporal lobe, particularly medially. Single photon tomography with [123I]epidepride allows visualization of extrastriatal dopamine D2 receptors in man.
authors: Department of Radiology, Vanderbilt University School of Medicine, Nashville, TN 37232.
authors: R M
authors: RM
authors: Kessler
authors: N S
authors: NS
authors: Mason
authors: J R
authors: JR
authors: Votaw
authors: T
authors: T
authors: De Paulis
authors: J A
authors: JA
authors: Clanton
authors: M S
authors: MS
authors: Ansari
authors: D E
authors: DE
authors: Schmidt
authors: R G
authors: RG
authors: Manning
authors: R L
authors: RL
authors: Bell
mesh_terms: D000328:Adult; D001549:Benzamides / Q000493:pharmacokinetics; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D011759:Pyrrolidines / Q000493:pharmacokinetics; D017448:Receptors, Dopamine D2 / Q000187:drug effects / Q000378:metabolism*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D001549:Benzamides; D007457:Iodine Radioisotopes; D011759:Pyrrolidines; D017448:Receptors, Dopamine D2; C063525:epidepride