Adjuvanted oral vaccines should not induce allergic responses to dietary antigens.
Oral vaccines may contain adjuvants which might elicit allergies against dietary proteins. Four antigens were used to measure such an effect--ovalbumin, soya bean protein, lactalbumin and gluten. Neither guinea pigs nor mice showed IgE responses after oral administration of adjuvanted vaccines containing lactalbumin and gluten. No IgE responses were detected in mice with any of these antigens after oral immunization, but, in the guinea pig, nine out of 18 animals reacted to either ovalbumin or soya bean protein and none reacted to lactalbumin and gluten. It is concluded that the risk of allergy induction against normal dietary proteins is low but such tests should be applied to potential adjuvanted oral vaccines to measure any possible contraindication, especially with atopic individuals.
Stewart-Tull
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DE
Department of Microbiology, University of Glasgow, UK.
Jones
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AC
D000284:Administration, Oral; D000485:Allergens / Q000008:administration & dosage; D000818:Animals; D004044:Dietary Proteins / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D005512:Food Hypersensitivity / Q000209:etiology*; D005620:Freund's Adjuvant / Q000008:administration & dosage / Q000009:adverse effects*; D006168:Guinea Pigs; D006386:Hemagglutination Tests; D007073:Immunoglobulin E / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D051379:Mice; D010323:Passive Cutaneous Anaphylaxis; D014612:Vaccines / Q000008:administration & dosage / Q000009:adverse effects*
D000485:Allergens; D004044:Dietary Proteins; D007074:Immunoglobulin G; D014612:Vaccines; D007073:Immunoglobulin E; D005620:Freund's Adjuvant