title: Sequential measurement of the median nerve somatosensory evoked potential during isoflurane anaesthesia in children.
abstract: We have used sequential measurements of median nerve somatosensory evoked potentials (mnSSEP) in 10 children to estimate the equilibration time of an inhalation anaesthetic agent between alveolar gas, arterial blood and brain. MnSSEP were obtained sequentially every 90-180 s. After control measurements in the absence of isoflurane, the end-tidal concentration was increased stepwise (0.25, 0.5 and 0.75 MAC). Each isoflurane concentration was maintained for 15 min. The point at which the N20 latency reached stability was determined; the mean time between reaching a stable end-tidal isoflurane concentration and this point varied between 5 min 16 s and 7 min 37 s. This technique may be useful in circumstances in which a "steady state" of anaesthesia is important, such as in the determination of MAC or during intraoperative monitoring of evoked potentials.
authors: Department of Anaesthetics, Hospital for Sick Children, London.
authors: D G
authors: DG
authors: Mason
authors: D
authors: D
authors: Higgins
authors: S G
authors: SG
authors: Boyd
authors: A R
authors: AR
authors: Lloyd-Thomas
mesh_terms: D000769:Anesthesia, Inhalation; D002648:Child; D002675:Child, Preschool; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D006801:Humans; D007223:Infant; D007530:Isoflurane / Q000494:pharmacology*; D008475:Median Nerve / Q000502:physiology*; D016343:Monitoring, Intraoperative; D013990:Tidal Volume; D013997:Time Factors
chemical_list: D007530:Isoflurane