title: Collagen and gelatin-impregnated vascular grafts--is their thrombogenicity enhanced? An experimental study.
abstract: The early thrombogenicity of dacron vascular grafts with and without impregnation with collagen (n = 7) or gelatin (n = 7) was evaluated in a sheep carotid artery interposition model. Autologous platelets were labelled with 32P and reinjected. Flow was reduced to 25 ml/min to mimic a situation with poor run-off and the graft thrombogenicity was studied for 4 hours. The results showed no difference as regards patency, thrombus-free surface, or uptake of 32P-labelled platelets between collagen- or gelatin-impregnated grafts and their parent dacron grafts. Thus, no difference in early graft thrombogenicity could be documented.
authors: Department of Surgery, Lund University, Malmö General Hospital, Sweden.
authors: N
authors: N
authors: Jensen
authors: B
authors: B
authors: Lindblad
authors: P
authors: P
authors: Dougan
authors: D
authors: D
authors: Bergqvist
mesh_terms: D000818:Animals; D001807:Blood Vessel Prosthesis; D002339:Carotid Arteries / Q000601:surgery; D003094:Collagen; D005260:Female; D005780:Gelatin; D006083:Graft Occlusion, Vascular / Q000097:blood*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology; D011093:Polyethylene Terephthalates; D011474:Prosthesis Design; D012307:Risk Factors; D012756:Sheep
chemical_list: D011093:Polyethylene Terephthalates; D005780:Gelatin; D003094:Collagen