The P300 event-related potential. The effects of sleep deprivation.
We monitored 15 healthy young adults during 18 hours of sleep deprivation. Subjects were repeatedly tested on measures of the P300 (P3) event-related potential, reaction time, body temperature, and a subjective rating of fatigue. Statistically significant decreases in P3 amplitude (P < or = .01) and increases in P3 latency (P < or = .0001) were found during sleep deprivation. These changes correlated with body temperature and fatigue and were not due to circadian variation. Reaction time did not show a significant change over time. We conclude that the P3 potential is a more sensitive cognitive measure of sleep deprivation than reaction time, a measure commonly used in previous studies. We provide a review of the literature on the P3 and recommend the use of the P3 as a marker to examine sleep deprivation in health professionals.
Morris
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AM
Center for Occupational and Environmental Health, University of California, San Francisco.
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Y
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Lee
K A
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Lash
A A
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Becker
C E
CE
D000328:Adult; D001831:Body Temperature; D003071:Cognition / Q000502:physiology*; D005071:Evoked Potentials; D005221:Fatigue; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011930:Reaction Time / Q000502:physiology; D012892:Sleep Deprivation / Q000502:physiology*