title: Regulation of isotype switching.
abstract: In the past year, our understanding of the mechanisms that regulate isotype switching has significantly progressed. Activation of germ line transcription by isotype-specific cytokines is emerging as a crucial mechanism for increasing the accessibility of a particular switch region, and targeting switch recombination.
authors: Division of Immunology, Children's Hospital, Boston, Massachusetts 02115.
authors: D
authors: D
authors: Vercelli
authors: R S
authors: RS
authors: Geha
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000235:genetics / Q000276:immunology; D007073:Immunoglobulin E / Q000235:genetics / Q000276:immunology; D007132:Immunoglobulin Isotypes / Q000235:genetics*; D007134:Immunoglobulin Switch Region
chemical_list: D007070:Immunoglobulin A; D007132:Immunoglobulin Isotypes; D007073:Immunoglobulin E