Assessment of right ventricle dimensions with microsonometry in anesthetized rabbits.
Dimension measurements of the right ventricle are difficult to obtain because of its complex geometry, thus we evaluated a method of right ventricular dimension measurements. Crystals were placed on the ventral and dorsal side of the right ventricular free wall, approximately one-fourth of the right ventricular semicircle away from the septum, in the middle of a cranio-caudal axis of the ventricles. The effects of an increased (infusion of 20 mL/kg of 5% glucose for 3 min into seven rabbits), as well as decreased preload (nitroglycerin, 5 micrograms/kg/min i.v. n = 6) were measured and compared with changes during a placebo infusion (n = 6). The change in shortening of the right ventricle wall segment correlated with changes in both atrial natriuretic factor (ANF) plasma concentration (r = 0.89, p < 0.05) and central venous pressure (CVP) (r = 0.94, p < 0.05), respectively. Both these variables are influenced by right ventricular function and dimensions in healthy animals. Dimension measurements obtained across the free wall of the right ventricle appear to reflect right ventricular function well and should be useful in assessing the effects of drugs intended for the treatment of angina pectoris or heart failure.
Novosel
D
D
Sandoz Pharma Ltd., Basel, Switzerland.
Hof
A
A
Evenou
J P
JP
Hof
R P
RP
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood; D002496:Central Venous Pressure / Q000502:physiology; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006439:Hemodynamics; D008297:Male; D010919:Placebos; D011817:Rabbits; D014463:Ultrasonography / Q000379:methods; D016278:Ventricular Function, Right / Q000187:drug effects / Q000502:physiology*
D010919:Placebos; D009320:Atrial Natriuretic Factor