The relationship between mind, brain, and seizures.
The medical model of epilepsy suggests that seizures arise at random or in response to precise physiological events. Little weight is given to the part that ongoing brain activity may play in either precipitating or inhibiting seizures. In the focal epilepsies, the presence of damaged neurons that fire in the epileptic mode continuously and are called pacemaker cells has been demonstrated in both animal models and human epilepsy. If these pacemaker cells are firing all the time, why then do seizures arise only spasmodically? Behavior can be thought of as changes in the excitation and inhibition of populations of neurons. Therefore, it is likely that these excitatory and inhibitory waves will either increase or decrease the likelihood of seizures arising. The conditioning of the neurons to fire in volleys in a biofeedback paradigm, the conditioning of seizures in a classic Pavlovian sense, and the occurrence of seizures in response to behavioral changes has been shown in animal models of epilepsy and in humans. There is now evidence that children can both inhibit and generate their own seizures spontaneously. Many adult patients have behavioral strategies that they use either to inhibit or to stop the spreading seizures. In patients who have difficulties in coping with the stresses in their life, the voluntary generation of seizures may come to form a response to difficult situations. Thus, any complete epilepsy program must consider the patient, the behavior, and the relationship between seizures and behavior.
Fenwick
P B
PB
Institute of Psychiatry, Maudsley Hospital, London, England.
D000818:Animals; D001521:Behavior Therapy; D001921:Brain / Q000502:physiology* / Q000503:physiopathology; D002415:Cats; D004195:Disease Models, Animal; D004569:Electroencephalography; D004827:Epilepsy / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D006801:Humans; D008606:Mental Processes / Q000502:physiology*; D008959:Models, Neurological; D011603:Psychophysiology; D013850:Thinking / Q000502:physiology