Long-term histopathological study of new polypeptidic biomaterials.
The long-term histopathological evaluation of a new class of synthetic polypeptides, the poly(tert-butyloxycarbonylmethyl glutamates), as implantable drug delivery systems is addressed. This evaluation was performed in rat muscles over one year. The histological analysis included the measurement of many parameters, such as the type and thickness of the collagen capsule. The influence of the presence of progesterone, the selected active drug, could also be monitored over time.
Lescure
F
F
School of Pharmacy, University of Geneva, Switzerland.
Gurny
R
R
Doelker
E
E
Anderson
J M
JM
D000818:Animals; D001672:Biocompatible Materials / Q000493:pharmacokinetics / Q000633:toxicity; D001673:Biodegradation, Environmental; D015918:Infusion Pumps, Implantable / Q000009:adverse effects; D008422:Materials Testing; D009132:Muscles / Q000473:pathology; D009842:Oligopeptides / Q000493:pharmacokinetics / Q000633:toxicity; D051381:Rats; D013997:Time Factors
D001672:Biocompatible Materials; D009842:Oligopeptides; C062244:poly(tert-butyloxycarbonylmethyl)glutamate