Existence of a human urinary trypsin inhibitor (urinastatin)-like substance in the rat brain.
A human urinary trypsin inhibitor, urinastatin (UT)-like immunoreactive substance with trypsin inhibitory activity, was demonstrated in certain brain regions in rats, especially the cerebral cortex, hippocampus and hypothalamus. Although this UT-like substance in the rat brain displayed an N-terminal amino acid sequence similar to that of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), it did not show any GAPDH activity. These results indicate that the UT-like substance in the rat brain is a protein different from GAPDH and indicates a localized distribution within certain brain regions partly related to learning and memory.
Shikimi
T
T
Department of Pharmacology, Shimane Medical University, Japan.
Hattori
K
K
Takaori
S
S
D000595:Amino Acid Sequence; D000818:Animals; D015153:Blotting, Western; D001923:Brain Chemistry / Q000502:physiology*; D002846:Chromatography, Affinity; D004591:Electrophoresis, Polyacrylamide Gel; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008969:Molecular Sequence Data; D051381:Rats; D011921:Rats, Inbred WKY; D014361:Trypsin Inhibitors / Q000378:metabolism* / Q000652:urine
D006023:Glycoproteins; D014361:Trypsin Inhibitors; C028665:urinastatin