title: Hepatic disposition of methohexitone in patients undergoing coronary bypass surgery.
abstract: In order to clarify the relative contribution of hepatic metabolism to the short term disposition of methohexitone, we have measured hepatic blood flow during induction of anaesthesia with a 1.5-mg kg-1 i.v. bolus dose of methohexitone. Median hepatic clearance was 1.01 litre min-1 and hepatic extraction 87%. As a consequence of the high hepatic extraction, the hepatic clearance of methohexitone was closely dependent on hepatic plasma flow.
authors: Department of Anesthesiology, University of Goettingen, Germany.
authors: H
authors: H
authors: Lange
authors: H
authors: H
authors: Stephan
authors: C
authors: C
authors: Brand
authors: S
authors: S
authors: Zielmann
authors: H
authors: H
authors: Sonntag
mesh_terms: D000328:Adult; D000368:Aged; D000758:Anesthesia; D001026:Coronary Artery Bypass; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008102:Liver Circulation / Q000502:physiology; D008297:Male; D008723:Methohexital / Q000493:pharmacokinetics* / Q000494:pharmacology; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects
chemical_list: D008723:Methohexital