title: Systemic absorption of ocular cyclopentolate in children.
abstract: Cyclopentolate plasma levels were quantitated and heart rate and pupil size were monitored after ocular application of the drug to juveniles. In all, 12 children were given one 35-microliters eyedrop of either 1% cyclopentolate (n = 6) or placebo (n = 6) in randomized order in the lower cul-de-sac of one eye. A sensitive radioreceptor assay was used to determine the systemic drug absorption. With the exception of one child, detectable cyclopentolate concentrations were seen in plasma at as early as 3 min after the ocular drug application. There was a marked interindividual variation in peak plasma cyclopentolate concentrations ranging from undetectably low to 5.8 ng/ml (median, 2.9 ng/ml). In some children a second drug concentration peak was detected. Cyclopentolate increased the pupillary diameter from 4.8 +/- 1 mm before drug application to 8 +/- 0.9 mm at 30 min after administration, but the children's heart rate did not alter.
authors: Department of Ophthalmology, University of Turku, Finland.
authors: K
authors: K
authors: Lahdes
authors: R
authors: R
authors: Huupponen
authors: T
authors: T
authors: Kaila
authors: T
authors: T
authors: Ali-Melkkilä
authors: L
authors: L
authors: Salminen
authors: M
authors: M
authors: Saari
mesh_terms: D000042:Absorption; D002648:Child; D003519:Cyclopentolate / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005123:Eye / Q000378:metabolism*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D009883:Ophthalmic Solutions; D011680:Pupil / Q000187:drug effects; D011869:Radioligand Assay; D011897:Random Allocation; D013285:Strabismus / Q000601:surgery
chemical_list: D009883:Ophthalmic Solutions; D003519:Cyclopentolate