[Effect of peptides of the tracheal mucosa and vascular wall in acute hyperoxic lung injury].
It was demonstrated that peptides of the tracheal mucosa (PTM) and peptides of the vascular wall (PVW) produce a certain protective effect in hyperoxic lung injury. The peptides, (PTM to a greater measure) prolonged the survival of mice and inhibited the dynamics of the growth of the lung coefficient in rats. PTM reduced the formation of malonic dialdehyde and increased the activity of glucose-6-phosphate dehydrogenase in the lungs. Morphometric studies showed that PTM produce a more marked inhibiting effect on exudation in to the alveoli; besides, the administration of PTM contributed greatly to maintenance of the empty space and "total volume" of the alveoli.
Khavinson
V Kh
VKh
Kozhemiakin
A L
AL
Kuleshov
V I
VI
Okuneva
N E
NE
D000818:Animals; D004730:Endothelium, Vascular / Q000737:chemistry*; D008171:Lung Diseases / Q000139:chemically induced / Q000401:mortality / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D009092:Mucous Membrane / Q000737:chemistry; D010100:Oxygen / Q000633:toxicity*; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014132:Trachea / Q000098:blood supply*
D010455:Peptides; D010100:Oxygen
Deĭstvie peptidov sosudistoĭ stenki i slizistoĭ obolochki trakhei pri ostrom giperoksicheskom povrezhdenii legkikh.