title: [The mechanism of action of chorionic gonadotropin on lactate dehydrogenase activity].
abstract: The purpose of this report is to demonstrate that chorionic gonadotropin (CG) interacts nonspecifically with lactate dehydrogenase changing its catalytic activity. The binding in vitro of CG (5 mg/ml) to the enzyme is accompanied by conformational changes of its protein and kinetic characteristics. It may be possible that chorionic gonadotropin exercises a controlling influence on lactate dehydrogenase activity in the cell.
authors: Iu V
authors: IuV
authors: Zimin
authors: I M
authors: IM
authors: Solopaeva
mesh_terms: D000818:Animals; D002384:Catalysis / Q000187:drug effects; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D066298:In Vitro Techniques; D007770:L-Lactate Dehydrogenase / Q000187:drug effects* / Q000378:metabolism; D009132:Muscles / Q000201:enzymology; D013379:Substrate Specificity / Q000187:drug effects; D013552:Swine
chemical_list: D006063:Chorionic Gonadotropin; D007770:L-Lactate Dehydrogenase
vernacular_title: K mekhanizmu deĭstviia khorionicheskogo gonadotropina na aktivnost' laktatdegidrogenazy.