Secretory regulation of 19-hydroxyandrostenedione in normal man.
To evaluate the secretory regulation of 19-hydroxyandrostenedione (19-OH-AD), its plasma concentration was measured before and after stimulation and inhibition tests for the ACTH-adrenal axis and the renin-angiotensin system in 50 normal subjects. Basal levels of plasma 19-OH-AD did not correlate with either those of plasma renin activity (PRA) or the plasma aldosterone concentration (PAC), but positively correlated with those of plasma cortisol. Plasma 19-OH-AD was stimulated by 0.25 mg ACTH-(1-24) and was suppressed by 1 mg dexamethasone (DEX) as were plasma cortisol and PAC. On the other hand, with 2-h standing alone or iv 40 mg furosemide plus 2-h standing, plasma 19-OH-AD and cortisol did not increase but PRA and PAC did. With iv furosemide plus 2-h standing with 3 mg DEX pretreatment, plasma 19-OH-AD and cortisol did not respond either, but PRA and PAC increased. With 25 mg oral captopril following 1-h standing with 3 mg DEX pretreatment, plasma 19-OH-AD and cortisol did not change but PAC decreased. These results indicate that the secretion of 19-OH-AD is mainly under the control of the ACTH-adrenal axis rather than the renin-angiotensin system.
Morita
H
H
Third Department of Internal Medicine, Gifu University School of Medicine, Japan.
Mune
T
T
Yasuda
K
K
Mercado-Asis
L B
LB
Murayama
M
M
Yamakita
N
N
Miyazaki
S
S
Miura
K
K
D000293:Adolescent; D000328:Adult; D000450:Aldosterone / Q000097:blood; D000735:Androstenedione / Q000031:analogs & derivatives* / Q000378:metabolism; D002216:Captopril / Q000494:pharmacology; D003366:Cosyntropin / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D005665:Furosemide / Q000494:pharmacology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000378:metabolism; D011863:Radioimmunoassay; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects
D003366:Cosyntropin; D000735:Androstenedione; D000450:Aldosterone; D005665:Furosemide; D003907:Dexamethasone; D002216:Captopril; C011482:19-hydroxy-4-androstene-3,17-dione; D012083:Renin; D006854:Hydrocortisone