[The effect of taurine on the activity of transport ATPases and of energy metabolism enzymes in different tissues of rats with acute hypoxic hypoxia].
The membrane activity of Na+, K(+)-ATPase, Mg2+, Ca(2+)-ATPase, mitochondrial NAD-isocitrate dehydrogenase, mitochondrial and cytosolic L-glycerol-3-phosphate dehydrogenase was determined in the liver and brain of Wistar rats under acute hypoxic hypoxia against the background of preventive taurine administration. It was shown that preliminary taurine treatment prevented a decrease of hypoxia in activity of Na+. K(+)-ATPase and mitochondrial calcium-dependent enzymes, mostly in the liver. Changes in the intracellular calcium content and biomembrane structure have been discussed as the mechanisms of the taurine effect on the enzymes' activity.
Man'kovskaia
I N
IN
Vavilova
G L
GL
Kharlamova
O N
ON
Nosar'
V I
VI
Bratus'
L V
LV
D000208:Acute Disease; D000251:Adenosine Triphosphatases / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D004734:Energy Metabolism / Q000187:drug effects*; D005993:Glycerolphosphate Dehydrogenase / Q000187:drug effects / Q000378:metabolism; D000860:Hypoxia / Q000201:enzymology*; D007521:Isocitrate Dehydrogenase / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013654:Taurine / Q000494:pharmacology*
D013654:Taurine; D005993:Glycerolphosphate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D000251:Adenosine Triphosphatases
Vliianie taurina na aktivnost' transportnykh ATP-az i fermentov énergeticheskogo obmena v raznykh tkaniakh krys pri ostroĭ gipoksicheskoĭ gipoksii.