title: Longitudinal survey of anticardiolipin antibodies in systemic lupus erythematosus. Relationships with clinical manifestations and disease activity in an Italian series.
abstract: One hundred and two patients suffering from systemic lupus erythematosus were observed over 5-140 months. IgG and IgM anticardiolipin antibodies (aCL) were searched for by ELISA in 448 serum samples, and were found in 88 (86.3%) patients on at least one occasion. Changes of aCL levels and isotypes were recorded in most patients. In patients with medium (20-80 U. GPL and/or MPL) and high (> 80 U. GPL and/or MPL) aCL levels associations with thrombosis, neurological manifestations, cerebrovascular disease, prolonged aPTT, and thrombocytopenia were found. A highly significant statistical association was found between IgG aCL and the occurrence of active disease (p < 0.0001).
authors: Institute of Clinical Medicine, 1st Faculty of Medicine, University of Naples, Italy.
authors: U
authors: U
authors: Picillo
authors: S
authors: S
authors: Migliaresi
authors: M R
authors: MR
authors: Marcialis
authors: A
authors: A
authors: Longobardo
authors: F
authors: F
authors: La Palombara
authors: G
authors: G
authors: Tirri
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D017153:Antibodies, Anticardiolipin / Q000032:analysis*; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005313:Fetal Death / Q000453:epidemiology; D005500:Follow-Up Studies; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008137:Longitudinal Studies; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000453:epidemiology / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D017153:Antibodies, Anticardiolipin