Cloning and sequencing of an hsp70 gene of Schistosoma mansoni.
Schistosomes have a complex life cycle (vertebrate and molluscan hosts as well as larvae living freely in water) in which they are exposed to different environments and temperatures (20 degrees C - 37 degrees C). Since heat shock genes are activated in response to stress and during development [1], it is of interest to study the hsp70 gene family in schistosome. To approach this issue we have isolated from Schistosoma mansoni a genomic clone containing the complete coding region of hsp70 and the 5' flanking DNA with transcription regulatory elements including HSE (heat shock element) sequences.
Neumann
S
S
Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.
Ziv
E
E
Lantner
F
F
Schechter
I
I
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D017238:Genes, Helminth / Q000235:genetics*; D006360:Heat-Shock Proteins / Q000235:genetics*; D015801:Helminth Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics; D012550:Schistosoma mansoni / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
D006360:Heat-Shock Proteins; D015801:Helminth Proteins