Risk of ventricular dysrhythmias during 1-hour infusions of amphotericin B in patients with preserved renal function.
In order to assess the safety of 1-h infusions of amphotericin B (AMB), we prospectively monitored 213 1-h infusions of AMB (dose range, 0.27 to 0.89 mg/kg of body weight) in 27 patients with creatinine clearances of > 25 ml/min. Holter monitor tracings during 1-h infusions were compared with those during a 4-h baseline period of monitoring. There were no ventricular dysrhythmias during 1-h infusions of AMB that were not present during baseline monitoring. Nausea and/or rigors were noted for 32 (15%) infusions in six (22%) patients. No patient exhibited a temperature rise of > 1 degree C. We conclude that, in doses of up to 0.9 mg/kg, AMB does not appear to induce asymptomatic ventricular dysrhythmias when administered over 1 h to patients with creatinine clearances of > 25 ml/min.
Bowler
W A
WA
Department of Internal Medicine (Infectious Disease Division and Cardiology Division), Naval Hospital, San Diego, California 92134-5000.
Weiss
P J
PJ
Hill
H E
HE
Hoffmeister
K A
KA
Fleck
R P
RP
Blacky
A R
AR
Oldfield
E C
EC
D000293:Adolescent; D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000008:administration & dosage / Q000009:adverse effects*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D004334:Drug Administration Schedule; D015716:Electrocardiography, Ambulatory; D005260:Female; D006352:Heart Ventricles / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D007668:Kidney / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014693:Ventricular Fibrillation / Q000139:chemically induced; D016276:Ventricular Function / Q000187:drug effects*
D000666:Amphotericin B