Potential neurotoxin formation in thermally degraded synthetic ester turbine lubricants.
Under extreme conditions of thermal degradation, a potent neurotoxin, trimethylolpropane phosphate (TMPP), may be formed by reaction of tricresyl phosphate (TCP, an anti-wear additive) and trimethylolpropane esters (TMPE) of carboxylic acids that may be contained in turbine engine lubricant formulations. The neurotoxin is only formed at extreme temperatures (350-700 degrees C), which has minimized concern for use of the synthetic lubricants under intended applications; however, since researchers are often not privy to the proprietary composition of such lubricants, extreme caution should be exercised in studies of or applications of synthetic lubricants degraded under extreme conditions.
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D000818:Animals; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry* / Q000633:toxicity; D004952:Esters / Q000737:chemistry* / Q000633:toxicity; D008153:Lubrication; D051379:Mice; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology*; D011409:Propylene Glycols / Q000737:chemistry* / Q000633:toxicity; D014317:Tritolyl Phosphates / Q000737:chemistry* / Q000633:toxicity
D019086:Bridged Bicyclo Compounds, Heterocyclic; D004952:Esters; D011409:Propylene Glycols; D014317:Tritolyl Phosphates; C065518:4-ethyl-1-phospha-2,6,7 trioxabicyclo(2.2.2)octane-1-oxide