title: [Long-term clinical observations of chronic active hepatitis HBsAg (+)].
abstract: This paper presents results of 3-18 year clinical observation of 48 patients with chronic active hepatitis HBsAg (+). 40 patients had suffered viral hepatitis for a period from 6 months to 3 years (avg. 1.5 year) before chronic active hepatitis manifested. Cirrhosis hepatis was a consequence of chronic active hepatitis in 52.1%, chronic active hepatitis in 45.8%, and chronic persistence in 2.1% of cases, during observation period. The average transition time from chronic active hepatitis to cirrhosis was 3 years. 48% of cirrhosis hepatis occurred within 2 years starting from recognition of chronic active hepatitis and 80% within 5 years. Most cases of cirrhosis were recorded if patients had been treated with penicillamine and prednisone (80% of cases), then with azathioprine and prednisone (48% of cases), while the least with ++non-immunosuppressive therapy (penicillamine, isoprinosine or "+hepatic protectors").
authors: Katedry i Kliniki Gastroenterologii AM, Lublinie.
authors: H
authors: H
authors: Cichoz-Lach
authors: J
authors: J
authors: Daniluk
authors: M
authors: M
authors: Słomka
authors: K
authors: K
authors: Celiński
authors: J
authors: J
authors: Pokora
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006509:Hepatitis B / Q000150:complications* / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006515:Hepatitis B virus / Q000276:immunology*; D006521:Hepatitis, Chronic / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D008103:Liver Cirrhosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D006514:Hepatitis B Surface Antigens
vernacular_title: Wieloletnie kliniczne obserwacje przewlekłego aktywnego zapalenia watroby HBsAg (+).