[Epileptiform activity in the somatosensory cortex of rats with trigeminal neuralgia].
It was shown in experiments on rats that penicillin 1 microliter microinjection (100 U) into the caudal nucleus of the spinal tract of the trigeminal nerve, accounting for formation of a generator of pathologically enhanced excitation (GREE), brings about in rats the pain syndrome with characteristic for trigeminal neuralgia behavioural manifestations and the emergence of epileptiform activity in the somatosensory cortex, especially pronounced in the contralateral hemisphere. The emergence of this activity reflects, on the one hand, the action of the GREE in the caudal nucleus of the trigeminal nerve and, on the other hand, the involvement of the somatosensory cortex taking over stimulation from the hyperactive caudal nucleus, into formation of a pathological algic system of this form of trigeminal neuralgia.
Kryzhanovskiĭ
G N
GN
Reshetniak
V K
VK
Igon'kina
S I
SI
Zinkevich
V A
VA
D000818:Animals; D004558:Electric Stimulation; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology*; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D008297:Male; D008845:Microinjections; D010406:Penicillins / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D013003:Somatosensory Cortex / Q000503:physiopathology*; D014277:Trigeminal Neuralgia / Q000139:chemically induced / Q000503:physiopathology*
D010406:Penicillins
Epileptiformnaia aktivnost' v somatosensornoĭ oblasti kory u krys c trigeminal'noĭ nevralgieĭ.