The echinoid immune system and the phylogenetic occurrence of immune mechanisms in deuterostomes.
In this article, Courtney Smith and Eric Davidson reinterpret the published data on immune function in lower deuterostomes and primitive chordates. It leads them to a new model of immune system phylogeny in which MHC-directed T-cell responses are the last to evolve and are not derived from subchordate self-nonself recognition systems.
Smith
L C
LC
Division of Biology, California Institute of Technology, Pasadena 91125.
Davidson
E H
EH
D000818:Animals; D000917:Antibody Formation; D002816:Chordata, Nonvertebrate / Q000276:immunology*; D004447:Echinodermata / Q000276:immunology*; D005399:Fishes / Q000276:immunology; D007111:Immunity, Cellular; D008954:Models, Biological; D010802:Phylogeny; D012098:Reproduction / Q000276:immunology; D012617:Sea Urchins / Q000276:immunology; D013045:Species Specificity; D014184:Transplantation, Homologous / Q000276:immunology; D014561:Urochordata / Q000276:immunology*