title: Aging in the T lymphocyte compartment. A developmental view.
abstract: A decline in the capacity of bone marrow cells to differentiate to T lymphocytes was found when cells from young and old donors were seeded onto an alymphoid fetal thymus. A step-by-step analysis of cell-cell interactions of the lymphohemopoietic cells and the thymic stroma indicated an effect of age on a variety of cell differentiation parameters. These included a decrease in the affinity of bone marrow cells to the stroma, and in their capacity to compete with the thymic lymphoid resident cells on colonization of the thymus. There was a significant decrease in the ability of cells of old donors to replicate sequentially within the thymic microenvironment. There was a reduced capacity of bone marrow cells from aging mice to express a developmental preference after seeding onto a syngeneic fetal thymus in a mixture with cells from allogeneic donors. We addressed the question whether the aging thymus contains increased levels of immature cells that fail to differentiate in the involuted thymic microenvironment by seeding thymocytes from young and old donors onto the fetal thymic stroma. The values of T cells that developed from the old donor inoculum were lower under these conditions. Our studies suggest that at least some of the manifestations of aging in the T cell compartment are related to developmentally programmed events in the lymphohemopoietic cell compartment.
authors: Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
authors: A
authors: A
authors: Globerson
authors: A
authors: A
authors: Sharp
authors: M
authors: M
authors: Fridkis-Hareli
authors: T
authors: T
authors: Kukulansky
authors: L
authors: L
authors: Abel
authors: A
authors: A
authors: Knyszynski
authors: R
authors: R
authors: Eren
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001853:Bone Marrow / Q000502:physiology; D001854:Bone Marrow Cells; D002450:Cell Communication; D002455:Cell Division; D003584:Cytological Techniques; D005333:Fetus / Q000166:cytology; D008285:Major Histocompatibility Complex; D051379:Mice; D008810:Mice, Inbred C57BL; D013234:Stem Cells / Q000166:cytology / Q000502:physiology; D013601:T-Lymphocytes / Q000502:physiology*; D013950:Thymus Gland / Q000166:cytology / Q000196:embryology / Q000502:physiology