Light-induced endocapsular polymerization of injectable lens refilling materials.
The use of advanced phacoemulsification techniques enables the surgeon to remove opacified lens material while preserving a nearly complete capsular bag. For this reason, several groups are presently working on lens refilling techniques. We have developed a method for the injection of a liquid monomer into the lens capsule. The material can be polymerized by exposure to cold light (wavelength, 400-500 nm) within the capsular bag. Using cell-culture experiments, we selected an optically clear material that has cytotoxic properties when placed in direct contact with cells but does not release cytotoxic substances into the surrounding medium. We have shown that reflux of the liquid monomer into the anterior chamber can be avoided by using a material that can be polymerized within the capsule. Initial experiments in rabbits indicate that the technique can be used without inducing a significant postoperative inflammatory response or leading to morphological changes in the cornea or the retina.
Hettlich
H J
HJ
Klinik für Augenheilkunde, Medizinische Universität zu Lübeck, Federal Republic of Germany.
Lucke
K
K
Kreiner
C F
CF
D000818:Animals; D001672:Biocompatible Materials; D002387:Cataract Extraction / Q000379:methods*; D004261:DNA Replication; D005260:Female; D005549:Foreign-Body Reaction / Q000473:pathology; D007267:Injections; D007903:Lens Capsule, Crystalline / Q000166:cytology / Q000601:surgery*; D007910:Lenses, Intraocular; D008027:Light; D010865:Pilot Projects; D011108:Polymers / Q000494:pharmacology; D011817:Rabbits; D014407:Tumor Cells, Cultured
D001672:Biocompatible Materials; D011108:Polymers