Dose-response effects of oral loxiglumide on postprandial gall-bladder emptying in man.
The effect of two different single oral doses of loxiglumide (CR 1505, CAS 107097-80-3) on gall-bladder emptying induced by a 550-cal standard mixed meal in 6 healthy volunteers was studied. Following placebo, the maximal gall-bladder emptying occurred about 90 min after the meal (minimal residual gall-bladder volume 27.4% of basal volume). Loxiglumide 400 or 800 mg dose-dependently inhibited the physiologica gall-bladder emptying. Loxiglumide plasma levels dose-dependently increased. The inhibition of gall-bladder emptying and the kinetic of loxiglumide plasma levels were temporally related. The results of the present study confirm that oral loxiglumide is a potent orally active cholecystokinin (CCK) antagonist in man and that CCK is the major physiological mediator of gallbladder emptying in response to meal.
Malesci
A
A
Istituto di Medicina Interna, Università di Milano, Italy.
De Fazio
C
C
Festorazzi
S
S
Bonato
C
C
Valentini
A
A
Tacconi
M
M
Bekkering
M
M
Giacovelli
G
G
D'Amato
M
M
Rovati
L C
LC
D000328:Adult; D002766:Cholecystokinin / Q000037:antagonists & inhibitors*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005502:Food; D005704:Gallbladder / Q000033:anatomy & histology; D016473:Gallbladder Emptying / Q000187:drug effects*; D006801:Humans; D008297:Male; D011377:Proglumide / Q000031:analogs & derivatives* / Q000494:pharmacology
C053737:loxiglumide; D002766:Cholecystokinin; D011377:Proglumide