title: Antigen-induced protection against infection with Toxocara vitulorum larvae in mice.
abstract: Larvae of Toxocara vitulorum hatched and migrated in the tissues of normal mice. Larvae survived in reasonable numbers, particularly in the liver and, to a lesser extent, in the lungs and kidneys, for at least 4-7 days and in muscles, albeit only in low numbers, for at least 3 weeks. Oral infection of mice on three or more occasions with T. vitulorum eggs induced protection against a challenge infection with eggs of T. vitulorum. Prior parenteral immunization of mice with a variety of T. vitulorum soluble antigens (extracts, excretions/secretions, or perienteric fluid and their fractions) from adult parasites and/or infective larvae induced statistically significant protection against infection. The most effective protective immunogens were three or more injections with perienteric fluid from adults (100% protection) and excretions/secretions from infective larvae of T. vitulorum (> 92% protection).
authors: Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Sri Lanka.
authors: P H
authors: PH
authors: Amerasinghe
authors: R P
authors: RP
authors: Rajapakse
authors: S
authors: S
authors: Lloyd
authors: S T
authors: ST
authors: Fernando
mesh_terms: D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology*; D005260:Female; D007114:Immunization; D007668:Kidney / Q000469:parasitology; D007814:Larva / Q000276:immunology; D008099:Liver / Q000469:parasitology; D008168:Lung / Q000469:parasitology; D008297:Male; D051379:Mice; D009132:Muscles / Q000469:parasitology; D014119:Toxocara / Q000276:immunology*; D014120:Toxocariasis / Q000517:prevention & control*
chemical_list: D000947:Antigens, Helminth