Pharmacokinetics of a clarithromycin suspension in infants and children.
The single- and multiple-dose pharmacokinetics of clarithromycin and its 14-(R)-hydroxylated metabolite in infants and children were studied after oral administration under fasting and nonfasting conditions. Drug absorption appeared to be rapid following a brief delay in its onset; the mean peak concentrations in plasma (Cmax) for clarithromycin were reached within about 3 h under both conditions. The mean Cmax for the parent drug were 3.59 and 4.58 micrograms/ml in single-dose fasting and nonfasting patients, and the respective Cmax for the metabolite were 1.19 and 1.26 micrograms/ml. Data indicate good absorption and no significant effects by food. There was no unusual accumulation in the area under the concentration-time curve and Cmax in the multiple-dose group.
Gan
V N
VN
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235-9063.
Chu
S Y
SY
Kusmiesz
H T
HT
Craft
J C
JC
D000284:Administration, Oral; D002626:Chemistry, Pharmaceutical; D002648:Child; D002675:Child, Preschool; D017291:Clarithromycin / Q000378:metabolism / Q000493:pharmacokinetics*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D013535:Suspensions
D013535:Suspensions; D017291:Clarithromycin