Chemoprevention of chemically induced skin tumor development by diallyl sulfide and diallyl disulfide.
Garlic and onion oil have been shown to inhibit chemically induced skin tumor development in mice. In the present study, the effects of diallyl sulfide and diallyl disulfide, oil-soluble constituents of garlic and onion, on 7,12-dimethylbenz(a)anthracene-induced and 12,O-tetradecanoylphorbol-13-acetate-promoted skin tumor formation were examined in SENCAR mice. Topical application of diallyl sulfide or diallyl disulfide significantly inhibited skin papilloma formation from the ninth week of promotion and significantly increased the rate of survival in the murine model. Our findings support earlier evidence that these naturally occurring compounds may be useful for the chemoprevention of certain types of tumors.
Dwivedi
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College of Pharmacy, South Dakota State University, Brookings 57007.
Rohlfs
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Jarvis
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Engineer
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D015127:9,10-Dimethyl-1,2-benzanthracene; D000498:Allyl Compounds; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D004220:Disulfides / Q000627:therapeutic use*; D005737:Garlic / Q000737:chemistry*; D051379:Mice; D010212:Papilloma / Q000139:chemically induced / Q000517:prevention & control*; D010946:Plants, Medicinal; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013440:Sulfides / Q000627:therapeutic use*; D013755:Tetradecanoylphorbol Acetate
D000498:Allyl Compounds; D000970:Antineoplastic Agents; D004220:Disulfides; D013440:Sulfides; D015127:9,10-Dimethyl-1,2-benzanthracene; C028009:diallyl disulfide; C038491:allyl sulfide; D013755:Tetradecanoylphorbol Acetate