Glisoprenins, new inhibitors of acyl-CoA: cholesterol acyltransferase produced by Gliocladium sp. FO-1513. II. Structure elucidation of glisoprenins A and B.
The structure of glisoprenins A and B, novel acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors, was determined by spectroscopic analyses, mainly 1H and 13C NMR and MS. Glisoprenin A was deduced to be a tetrahydroxynonaprenol and glisoprenin B to be an oxidative modification of glisoprenin A.
Nishida
H
H
Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
Huang
X H
XH
Tomoda
H
H
Omura
S
S
D005233:Fatty Alcohols; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D003904:Mitosporic Fungi / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000494:pharmacology
D005233:Fatty Alcohols; C077321:glisoprenin A; C077322:glisoprenin B; D002785:Sterol O-Acyltransferase