Vertical transmission of HTLV-1 in HTLV-1 carrier rat.
A female F344 rat was injected with 2.4 x 10(6) MT-2 cells intravenously at 3 and 4 weeks old, and was mated with a non-infected male rat at the 17th week after injection, when the dam rat contained HTLV-1 provirus in the peripheral blood mononuclear cells as determined by polymerase chain reaction. HTLV-1 provirus was detected in at least 2 out of 9 offspring. This system should be useful for studies on the routes and prevention of vertical transmission and on elimination of once-transmitted HTLV-1.
Ami
Y
Y
Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki.
Kushida
S
S
Matsumura
M
M
Yoshida
Y
Y
Kameyama
T
T
Sugiyama
Y
Y
Yagami
K
K
Uchida
M
M
Uchida
K
K
Koiso
K
K
D000818:Animals; D000831:Animals, Newborn / Q000382:microbiology*; D005260:Female; D015481:HTLV-I Antibodies / Q000302:isolation & purification*; D015490:HTLV-I Infections / Q000635:transmission*; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction; D051381:Rats; D011916:Rats, Inbred F344
D015481:HTLV-I Antibodies