Morphine metabolism in neonates and infants.
The metabolism of morphine was studied in seven fullterm neonates and five infants receiving a continuous infusion of morphine. All the patients had detectable plasma concentrations of morphine 3-glucuronide (M3G) and 10 had detectable concentrations of morphine 6-glucuronide (M6G). The mean plasma clearance of morphine was 20.1 ml min-1 kg-1 in neonates and 23.4 ml min-1 kg-1 in the group as a whole. The M3G/morphine ratio (7.3) was higher than that previously reported for preterm neonates (5.0) but lower than that reported for children (23.9).
Choonara
I
I
Institute of Child Health, Alder Hey Children's Hospital, Liverpool.
Lawrence
A
A
Michalkiewicz
A
A
Bowhay
A
A
Ratcliffe
J
J
D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D009020:Morphine / Q000378:metabolism* / Q000493:pharmacokinetics; D009022:Morphine Derivatives / Q000097:blood; D013050:Spectrometry, Fluorescence
D009022:Morphine Derivatives; C035349:morphine-6-glucuronide; D009020:Morphine; C018108:morphine-3-glucuronide