[Role of TGF-beta in glomerular diseases].
Accumulation of extracellular matrix (ECM) is a major histological change in glomerular diseases that progress to chronic renal failure. Such accumulation can be mediated by increased production of molecular signal such as cytokines. Transforming growth factor beta 1 (TGF-beta 1) has a combined effect of enhancing the synthesis of ECM, while inhibiting the proteolytic degradation of newly formed matrix proteins. TG1-F beta 1 has stimulative effects on the production of ECM by cultured rat mesangial cells. In an experimental glomerulonephritis, there was a close association between elevated expression of the TGF-beta 1 mRNA and development of glomerulonephritis. Treatment of glomerulonephritic rats with antiserum directed to a synthetic peptide from mature TGF-beta 1 prevented the histological accumulation of ECM in glomeruli. These results suggest that TGF-beta 1 may participate in glomerular matrix expansion.
Okuda
S
S
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University.
D000818:Animals; D002455:Cell Division; D002478:Cells, Cultured; D003094:Collagen / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D005920:Glomerular Mesangium / Q000166:cytology / Q000378:metabolism*; D005921:Glomerulonephritis / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D011509:Proteoglycans / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000502:physiology*
D011509:Proteoglycans; D016212:Transforming Growth Factor beta; D003094:Collagen