title: [der(1;7) (q10;p10) in three patients with malignant hematologic disorders].
abstract: The chromosome der(1;7) (q10;p10) is a derivative chromosome consisting of the short arm of chromosome 7 and the long arm of chromosome 1. We observed this abnormality in three patients with acute myeloblastic leukemia (AML), myelodysplastic syndrome (MDS), or myeloproliferative disorder (MPD). Case 1 was a 76-yr-old male with a history of IgG myeloma treated with melphalan, cyclophosphamide, vincristine, and prednisolone (MEVP). AML-M1 developed one and half years after discontinuation of the MEVP therapy. Case 2 was a 39-yr-old male with MDS. Case 3 was a 56-yr-old male with refractory anemia with excess of blasts in transformation that evolved from primary myelofibrosis. Chromosome analyses revealed der(1;7) (q10;p10) in bone marrow cells of the three patients. All patients failed to respond to chemotherapy, and died within four months after the diagnosis. Thus, der (1;7) (q10;p10) may indicate a very poor prognostic outcome in patients with malignant hematologic disorders.
authors: Department of Clinical Laboratories, Saitama Central Hospital.
authors: H
authors: H
authors: Yokoo
authors: Y
authors: Y
authors: Okada
authors: K
authors: K
authors: Tominaga
authors: M
authors: M
authors: Tsuji
authors: T
authors: T
authors: Takagi
authors: N
authors: N
authors: Maseki
authors: M
authors: M
authors: Sakurai
authors: Y
authors: Y
authors: Kaneko
mesh_terms: D000328:Adult; D000368:Aged; D002878:Chromosomes, Human, Pair 1; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D009196:Myeloproliferative Disorders / Q000235:genetics*; D014178:Translocation, Genetic