title: Use of oral stable strontium to provide an index of intestinal calcium absorption in chronic ambulatory peritoneal dialysis patients.
abstract: Recent interest in the role of oral calcium carbonate and low calcium dialysate has emphasised the need for a simple, safe and inexpensive test of intestinal calcium absorption. The stable, non-radioactive, strontium absorption test fits these requirements. Stable strontium and calcium-45 were administered simultaneously to 19 fasting CAPD patients and their serum levels were subsequently measured. There was a close correlation between the absorption of calcium and strontium at both 60 and 120 min post-ingestion. The two markers resulted in the same classification of patients as normal or malabsorbers in 18 of 19 cases (95%), suggesting that strontium could be substituted for calcium-45 in a 60-min test of absorption enabling safe, simple and repeated measurements in renal failure patients.
authors: Department of Renal Medicine, Manchester Royal Infirmary, UK.
authors: A J
authors: AJ
authors: Hutchison
authors: H F
authors: HF
authors: Boulton
authors: K
authors: K
authors: Herman
authors: J P
authors: JP
authors: Day
authors: M
authors: M
authors: Prescott
authors: R
authors: R
authors: Gokal
mesh_terms: D000284:Administration, Oral; D002117:Calcitriol / Q000097:blood; D002118:Calcium / Q000493:pharmacokinetics*; D002132:Calcium Radioisotopes; D004355:Drug Stability; D005260:Female; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology*; D008297:Male; D010531:Peritoneal Dialysis, Continuous Ambulatory; D015203:Reproducibility of Results; D013324:Strontium / Q000008:administration & dosage / Q000493:pharmacokinetics
chemical_list: D002132:Calcium Radioisotopes; D002117:Calcitriol; D002118:Calcium; D013324:Strontium