Disturbances of mineral metabolism in teeth of rats receiving corticosteroids for 3 generations.
Distribution of calcium and phosphorus was investigated with quantitative and qualitative methods in teeth of rats chronically treated with low doses of corticosteroids for 3 generations. In animals from 2nd and 3rd generation, scanning electron microscopy revealed focal lesions in enamel and dentin. The disturbances of the mineral metabolism in teeth of corticosteroid-treated rats were also reflected by abnormal calcium and phosphorus content in enamel and dentin, as assessed by X-ray microanalysis.
Pawlicki
R
R
Department of Histology, Institute of Pediatrics, Academy of Medicine, Kraków, Poland.
Knychalska-Karwin
Z
Z
Stankiewicz
D
D
Jakób-Dolezal
K
K
Karwan
T
T
D000305:Adrenal Cortex Hormones / Q000633:toxicity*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D003743:Dental Enamel / Q000187:drug effects / Q000378:metabolism; D003804:Dentin / Q000187:drug effects / Q000378:metabolism; D005260:Female; D008297:Male; D010758:Phosphorus / Q000378:metabolism*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014018:Tissue Distribution; D014070:Tooth / Q000187:drug effects / Q000378:metabolism*
D000305:Adrenal Cortex Hormones; D010758:Phosphorus; D002118:Calcium