title: An analysis of two-period crossover designs with carry-over effects.
abstract: The crossover design is a type of longitudinal study with subjects receiving different treatments in different time periods. When carry-over effects are absent, the usual crossover design is structured so that all the information about treatment effects is contained in the within-subject contrasts; standard analyses are based on these within-subject contrasts and ignore any between-subject information. With carry-over effects present these standard analyses can be very inefficient, especially for suboptimal designs. We describe alternative approaches based on methods for the analysis of longitudinal data.
authors: Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115.
authors: N M
authors: NM
authors: Laird
authors: J
authors: J
authors: Skinner
authors: M
authors: M
authors: Kenward
mesh_terms: D008137:Longitudinal Studies; D015233:Models, Statistical