title: A proposed mechanism of anticancer activity of indomethacin.
abstract: The exact mechanism of anticancer activity of indomethacin still remains unclear. In view of the gathered observations and ideas, I hypothesize that the effect of indomethacin may be related--at least in certain cases--to its antagonism to gastrin/cholecystokinin family of peptides and/or to its agonistic activity to thromboxane A2 and melatonin. Future experiments in this direction are required.
authors: Institute of Endocrinology, Medical Academy of Lódź, Poland.
authors: M W
authors: MW
authors: Szkudliński
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy; D011453:Prostaglandins / Q000096:biosynthesis
chemical_list: D000970:Antineoplastic Agents; D011453:Prostaglandins; D007213:Indomethacin