Photosensitivity induced by quinidine sulfate: experimental reproduction of skin lesions.
A case of quinidine sulfate-induced photodermatitis is reported. The photosensitive reaction to quinidine sulfate was reproducible in the photopatch test and after oral intake plus ultraviolet A (UVA) irradiation. Eczematous dermatitis was provoked after intradermal injection of in vitro UVA-irradiated quinidine sulfate only in the presence of patient's serum. The clinical picture and histology suggest an allergic reaction. The photobinding of quinidine sulfate to a potential carrier protein in skin or serum seems to be of crucial importance for this type of photodermatitis. Quinidine sulfate is frequently used as an antiarrhythmic drug. Its potential as a photosensitizer should always be considered.
Schürer
N Y
NY
Department of Dermatology, University of Düsseldorf, Germany.
Hölzle
E
E
Plewig
G
G
Lehmann
P
P
D000368:Aged; D000369:Aged, 80 and over; D017454:Dermatitis, Photoallergic / Q000209:etiology* / Q000473:pathology; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D010328:Patch Tests; D011802:Quinidine / Q000009:adverse effects*; D012867:Skin / Q000187:drug effects / Q000473:pathology
D011802:Quinidine