Expression of 65-kd heat shock proteins in the inflammatory myopathies.
In normal muscle, 65-kd heat shock proteins (hsp) were detected on capillary endothelial cells, the mural elements of larger vessels, and some intracellular organelles, probably mitochondria. In the inflammatory myopathies, the 65-kd hsp were detected on inflammatory cells, degenerating and regenerating fibers, and on many but not all nonnecrotic muscle fibers invaded by T cells. The expression of the 65-kd hsp may be an immune-nonspecific response to cellular "stress," but hsp determinants could possibly also serve as autoantigen(s) recognized by autoreactive T cells.
Hohlfeld
R
R
Department of Neurology and Neuromuscular Research Laboratory, Mayo Clinic, Rochester, MN 55905.
Engel
A G
AG
D005455:Fluorescent Antibody Technique; D006360:Heat-Shock Proteins / Q000096:biosynthesis*; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D009132:Muscles / Q000378:metabolism; D009220:Myositis / Q000378:metabolism*
D006360:Heat-Shock Proteins