title: Protein restriction affects fat intake and serum lipids in children with chronic renal failure.
abstract: Cardiovascular complications in patients with chronic renal failure have been associated with the hyperlipidemia present in many of these patients. Since a protein-restricted diet is often prescribed in an attempt to preserve renal function, we performed a randomized controlled study in children with chronic renal failure on the effect of a protein-restricted diet on fat intake and serum lipid profiles. Although total fat intake did not change, we found a lower cholesterol intake and a higher polyunsaturated/saturated fat ratio in the patients with the protein-restricted diet. This is probably caused by the restriction of animal protein which results in the replacement of animal fat by vegetable fat in the protein-restricted group. Moreover, we observed an increase of plasma cholesterol and low-density lipoprotein cholesterol in patients with a normal protein intake which was absent in the protein-restricted group. This suggests a favourable effect of the institution of a protein-restricted diet on lipid intake and plasma profile.
authors: Department of Pediatrics, Sophia Children's Hospital, Erasmus University, Rotterdam, The Netherlands.
authors: J E
authors: JE
authors: Kist-van Holthe tot Echten
authors: J
authors: J
authors: Nauta
authors: G J
authors: GJ
authors: Boerma
authors: W C
authors: WC
authors: Hop
authors: C M
authors: CM
authors: Noordzij
authors: E D
authors: ED
authors: Wolff
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004041:Dietary Fats / Q000008:administration & dosage*; D004044:Dietary Proteins / Q000008:administration & dosage*; D005247:Feeding Behavior; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000178:diet therapy*; D008055:Lipids / Q000097:blood*; D011446:Prospective Studies
chemical_list: D004041:Dietary Fats; D004044:Dietary Proteins; D008055:Lipids