title: Comparison of frequencies of suicidal tendencies among patients receiving fluoxetine, lofepramine, mianserin, or trazodone.
abstract: To evaluate whether fluoxetine causes an important increased risk of suicidal behavior, we compared the frequency of attempted suicide, suicidal ideation, and aggressive behavior in persons who received fluoxetine, lofepramine, mianserin, and trazodone, based on information available on general practitioners' computers provided by Value Added Medical Products, Ltd. The frequency of these events was higher in fluoxetine users in the year prior to first treatment than in users of the other three antidepressants. The frequency of these events in the 90 days after the study drug was started was similar for the users of all four drugs. These data indicate that fluoxetine does not directly cause suicidal behavior at a substantially higher frequency than do lofepramine, mianserin, and trazodone.
authors: Boston Collaborative Drug Surveillance Program, Boston University Medical Center, Lexington, Massachusetts 02173.
authors: H
authors: H
authors: Jick
authors: M
authors: M
authors: Ulcickas
authors: A
authors: A
authors: Dean
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005473:Fluoxetine / Q000009:adverse effects*; D006801:Humans; D008127:Lofepramine / Q000009:adverse effects*; D008803:Mianserin / Q000009:adverse effects*; D008875:Middle Aged; D013405:Suicide / Q000706:statistics & numerical data*; D013406:Suicide, Attempted / Q000706:statistics & numerical data; D014196:Trazodone / Q000009:adverse effects*; D006113:United Kingdom
chemical_list: D005473:Fluoxetine; D008803:Mianserin; D008127:Lofepramine; D014196:Trazodone