Increasing resistance of enterococci to ciprofloxacin.
We determined that resistance to ciprofloxacin has emerged in enterococci over the last 5 years in our hospital, mainly in strains demonstrating the phenotype of high-level gentamicin resistance. All high-level-gentamicin-resistant isolates from 1985 and 1986 were susceptible, whereas 24% of isolates from 1989 and 1990 were resistant to ciprofloxacin. Plasmid and genomic DNA typing showed at least six unique strains exhibiting resistance, but one type accounted for 80% of recent resistant isolates, suggesting a role for cross infection in the emergence of resistance.
Schaberg
D R
DR
Division of Infectious Diseases, University of Michigan Medical School, Ann Arbor 48109.
Dillon
W I
WI
Terpenning
M S
MS
Robinson
K A
KA
Bradley
S F
SF
Kauffman
C A
CA
D002939:Ciprofloxacin / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000032:analysis / Q000235:genetics; D004352:Drug Resistance, Microbial / Q000502:physiology; D016983:Enterococcus / Q000187:drug effects* / Q000235:genetics; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D013997:Time Factors
D004269:DNA, Bacterial; D005839:Gentamicins; D002939:Ciprofloxacin