[Effects of haloperidol on extracellular contents of dopamine and its metabolites in the septum of rats during interspecies aggression].
The extracellular levels of dopamine (DA) and its metabolites in the septum of freely moving rats were studied using "push-pull" method during muricidal aggression before and after haloperidol (2 mg/kg, i. p.) treatment. Mouse-killing activity of the rats was accompanied by significant reduction of the output of DA and metabolites in this brain area. Haloperidol suppressed muricidal activity of the rats and increased the extracellular levels of DA metabolites. In contrast, the decrease of DA release monitoring during killing activity was not affected by haloperidol administration. Possible role of the septal dopaminergic mechanisms underlying muricidal behaviour and the drug effects is discussed.
Gaĭnetdinov
R R
RR
Gromov
A I
AI
Kudrin
V S
VS
Pletnikov
M S
MS
D015102:3,4-Dihydroxyphenylacetic Acid / Q000032:analysis*; D000374:Aggression / Q000187:drug effects; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004298:Dopamine / Q000032:analysis*; D004563:Electrochemistry; D006220:Haloperidol / Q000494:pharmacology*; D006719:Homovanillic Acid / Q000032:analysis*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D051381:Rats; D012688:Septum Pellucidum / Q000737:chemistry / Q000187:drug effects*; D013997:Time Factors
D015102:3,4-Dihydroxyphenylacetic Acid; D006220:Haloperidol; D004298:Dopamine; D006719:Homovanillic Acid
Vliianie galoperidola na vnekletochnoe soderzhanie dofamina i ego metabolitov v septume krys vo vremia mezhvidovoĭ agressii.