[Does timolol modify retinal hemodynamics in patients with normal pressure glaucoma?].
In 31 patients with normal-pressure glaucoma, retinal blood flow, diameter of the retinal vessels and velocity were measured with 2-point fluorometry and automatic measurement of the diameters before and after administration of 0.5% timolol over 2 weeks. After timolol therapy the tension was significantly decreased (before therapy: 18.26 +/- 2.50; after therapy: 15.61 +/- 2.56 mm Hg, P < or = 0.01). The arterial and venous diameters and blood flow were nearly unchanged, but a slight increase in the arterial and venous velocity was noted. We conclude that timolol does not significantly influence the retinal hemodynamics in patients with normal-pressure glaucoma.
Truckenbrodt
C
C
Universitäts-Augenklinik Jena.
Klein
S
S
Vilser
W
W
D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D005260:Female; D005901:Glaucoma / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D012171:Retinal Vessels / Q000187:drug effects*; D013999:Timolol / Q000008:administration & dosage*
D009883:Ophthalmic Solutions; D013999:Timolol
Beeinflusst Timolol die retinale Hämodynamik bei Patienten mit Normaldruckglaukom?