title: Susceptibility of anaerobic microorganisms to hypothiocyanite produced by lactoperoxidase.
abstract: The susceptibility of Capnocytophaga ochracea, Eikenella corrodens, Eubacterium yurii, Fusobacterium nucleatum, Peptostreptococcus micros, Prevotella intermedia, Selenomonas sputigena, Wolinella recta to hypothiocyanite (OSCN-) produced by the lactoperoxidase system was tested. Results showed a decrease of bacterial survival rate after OSCN- exposure, with an intra- and inter-species variability from 0 to 95% for C. ochracea, 34-100% for E. corrodens, 0-83% for E. yurii, 1-15% for F. nucleatum, 8-61% for P. micros, 0-100% for P. intermedia, 0-44% for S. sputigena and 0-8% for W. recta. The survival rate did not correlate with the NADH/OSCN- oxidoreductase activity present in the lysed bacteria (r = -0.3248; N = 15; NS).
authors: Faculty of Medicine, Free University of Brussels, Belgium.
authors: P
authors: P
authors: Courtois
authors: P
authors: P
authors: Majerus
authors: M
authors: M
authors: Labbé
authors: A
authors: A
authors: Vanden Abbeele
authors: E
authors: E
authors: Yourassowsky
authors: M
authors: M
authors: Pourtois
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects* / Q000201:enzymology; D005891:Gingivitis / Q000382:microbiology; D006801:Humans; D007784:Lactoperoxidase / Q000378:metabolism; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D010518:Periodontitis / Q000382:microbiology; D013861:Thiocyanates / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D013861:Thiocyanates; C014607:hypothiocyanite ion; D007784:Lactoperoxidase; D009247:NADH, NADPH Oxidoreductases