Evidence of a common regulation of IgE and IgG-subclass antibodies in humans during immunotherapy.
Based on a 3-year prospective study of 20 pollen-allergic patients, where a detailed analysis of the IgE, IgG1 and IgG4 immune response was performed, we propose that a common regulatory mechanism exists between the IgE and IgG1 synthesis and between IgE and IgG4 synthesis during immunotherapy. It was found that the IgE immune response to a number of antigens was quantitatively diminished during the period of immunotherapy when IgG1 was present early (week 12), and for other antigens there was a rise in IgE without an early IgG1 antibody response. Additionally, it was found that for some antigens a rise in IgE antibodies was contrasted by a fall in the IgG4 antibody response and for other antigens the opposite was true, indicating a regulatory mechanism between the IgE and the IgG4 synthesis. A statistical analysis showed that these findings were statistically significant at the 0.01% level for the IgE/IgG1 relationship and at the 0.05% level for the IgE/IgG4 relationship. These findings could have implications for future immunotherapy regimens.
Søndergaard
I
I
Chemistry Department, Royal Veterinary and Agricultural University, Copenhagen, Denmark.
Poulsen
L K
LK
Osterballe
O
O
Weeke
B
B
D003888:Desensitization, Immunologic; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000628:therapy; D007073:Immunoglobulin E / Q000096:biosynthesis / Q000145:classification / Q000276:immunology*; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000145:classification / Q000276:immunology*; D011058:Pollen / Q000276:immunology; D011446:Prospective Studies
D007074:Immunoglobulin G; D007073:Immunoglobulin E