Mapping of the Darier's disease gene by serogenetic markers: results in two large British kindreds.
The authors have carried out genetic linkage studies in 57 subjects from two large kindreds of Darier's disease, using a range of serological and biochemical polymorphisms of known chromosomal location. In these kindreds, about 7% of the genome has been excluded for close linkage to the Darier's disease gene. However, one family showed positive lod scores for linkage with the Duffy blood locus (1p13); lod scores were negative in the other family, but in the combined families the total score for this marker was still positive and does not completely exclude linkage.
Munro
C S
CS
University Department of Dermatology, University of Newcastle upon Tyne, UK.
Mastana
S S
SS
Papiha
S S
SS
D002874:Chromosome Mapping / Q000379:methods*; D002878:Chromosomes, Human, Pair 1; D007644:Darier Disease / Q000097:blood / Q000235:genetics*; D004375:Duffy Blood-Group System / Q000235:genetics; D004739:England; D005190:Family; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D010375:Pedigree
D004375:Duffy Blood-Group System; D005819:Genetic Markers