title: [Synthesis and radiosensitizing activity of nitro-arylimino-diethyl-sodium thiosulfate and nitro phenylalanine derivatives].
abstract: A series of compounds was synthesized, these compounds were tested for Hela-S3 cells in vitro for radiosensitizing activity. Five of them are 2,2'-(arylimino)-diethyl-sodium thiosulfate and two of them are phenylalanine derivatives. Most of them showed various degrees of radiosensitizing activity. Among them, SER of L07 was 1.89 at 3 mmol, and had low cytotoxicity to Hela-S3 cells, ID50 was 18.8 mmol. The relationship between radiosensitizing effects and chemical structure was discussed. It offers a base for further exploration of selectively hypoxic cell radiosensitizers.
authors: Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin.
authors: H X
authors: HX
authors: Liu
authors: B
authors: B
authors: Hu
authors: Z
authors: Z
authors: Li
authors: F S
authors: FS
authors: Mi
authors: Y
authors: Y
authors: Shen
mesh_terms: D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D009578:Nitrobenzenes / Q000138:chemical synthesis*; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D011838:Radiation-Sensitizing Agents / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D009578:Nitrobenzenes; D011838:Radiation-Sensitizing Agents; D010649:Phenylalanine