[IgG against A60 antigen and the tuberculin test in healthy individuals and tubercular patients].
BACKGROUND
Study of the relation between the antibodies against the A60 antigen and the tuberculin test.


METHODS
An indirect ELISA for detecting serum antibodies (IgG) against the antigen A60 and tuberculin test, has been applied to 20 patients with pulmonary tuberculosis, and 52 healthy persons without tuberculous history.


RESULTS
For the all people (healthy and patients) both techniques have had almost identical results in 76.4%. In the healthy people the ELISA A60 and tuberculin test positive results were: 20.7% and 26.9%, respectively. For the patients group this results were: 85% and 80%. These results were statistically significant (p = 0.0001).


CONCLUSIONS
In the healthy people the antibodies response against A60 antigen has a direct relationship with the results of the tuberculin test. The combined use of ELISA A60 and the tuberculin test improve their separate results.
Saz
J V
JV
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad de Alcalá de Henares, Madrid.
Ladrón de Guevara
M C
MC
D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology*; D000942:Antigens, Bacterial / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005189:False Positive Reactions; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D014374:Tuberculin Test; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000276:immunology*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D007074:Immunoglobulin G; C055539:mycobacterial A60 antigen
IgG frente al antígeno A60 y prueba de la tuberculina en individuos sanos y enfermos tuberculosos.