[Ibuprofen--successful in activated arthrosis. Results of a administration study].
Within the framework of an observational study carried out on a national basis and involving some 4,000 patients, a total of 1,156 patients with activated arthrosis were treated with oral ibuprofen and observed over a period of three weeks. It was found that, at a dose of 600 mg tid, ibuprofen led to significant remission rates in terms of the symptoms pain at rest, pain on movement, tenderness, restriction of movement, swelling, joint effusion, and morning stiffness. After the third week of treatment, these rates reached 90%. In the first week, rapid onset of action within the first 30 minutes was noted in about 50%, which increased in the third week to 65%. Since at the same time the tolerability of ibuprofen was also found to be good--4% side effects--it can be recommended also for long-term use in this indication.
Lewandowski
C
C
Gesellschaft für angewandte Psychologie mbH, Köln.
Hilken
K
K
Seifert
F
F
Rollinger
Y
Y
Vögtle-Junkert
U
U
D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy*; D010147:Pain Measurement; D016059:Range of Motion, Articular
D007052:Ibuprofen
Ibuprofen--erfolgreich bei aktivierter Arthrose. Ergebnisse einer Anwendungsbeobachtung.