Thyroid autoimmunity.
Antigenic structure remains a major focus in thyroid immunology. The genes for three major thyroid antigens--thyroglobulin, thyroid peroxidase and the thyrotropin receptor--were sequenced in the late 1980's, and epitopes for antibody and T cells have been reported within the last year. In addition, new evidence for selective use of T-cell receptor V gene segments in human thyroid infiltrates may point the way to specific immunotherapy.
Champion
B R
BR
Department of Immunology, Glaxo Inc., Research Triangle Park, North Carolina 27709.
Cooke
A
A
Rayner
D C
DC
D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000628:therapy; D015551:Autoimmunity; D006801:Humans; D007167:Immunotherapy; D007453:Iodide Peroxidase / Q000276:immunology; D011989:Receptors, Thyrotropin / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013954:Thyroglobulin / Q000276:immunology; D013959:Thyroid Diseases / Q000276:immunology / Q000628:therapy; D013961:Thyroid Gland / Q000276:immunology*
D001324:Autoantigens; D011989:Receptors, Thyrotropin; D013954:Thyroglobulin; D007453:Iodide Peroxidase