title: Identifying body fluid distribution by measuring electrical impedance.
abstract: The effects of critical illness on extracellular water (ECW) and total body water (TBW) were measured using (1) a multiple dilutional technique, and (2) whole body and regional bioelectrical impedance analysis (BIA) in a group of stable patients. Total body water and body resistance (R) were similar in patients when compared with normal healthy subjects (TBW: 45.1 +/- 4.5 vs. 46.2 +/- 3.4 L, p = 0.85; R: 518 +/- 42 vs. 500 +/- 22 omega, p = 0.70), and a significant relationship was present between these measurements (r = -0.87, p < 0.001). However, patients demonstrated an increase in ECW compared with controls (ECW: 18.6 +/- 1.3 vs. 14.7 +/- 1.1 L, p < 0.05). Expanded ECW values were associated with diminished electrical reactance (Xc) values (38 +/- 6 vs. 70 +/- 4 omega, p < 0.001) and these values were correlated (r = -0.67, p < 0.005). The ratio of Xc to R determined across the body and each of the segments was significantly lower in patients compared with controls (at least p < 0.005) and this ratio measured across a leg was the most sensitive predictor of health (Xc/R > or = 0.137) and disease (Xc/R < or = 0.101). Bioelectrical impedance analysis is a noninvasive and simple bedside technique that can be used to predict TBW and identify altered fluid distribution following critical illness.
authors: Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
authors: M R
authors: MR
authors: Scheltinga
authors: D O
authors: DO
authors: Jacobs
authors: T D
authors: TD
authors: Kimbrough
authors: D W
authors: DW
authors: Wilmore
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001825:Body Fluid Compartments; D001834:Body Water; D016638:Critical Illness; D017097:Electric Impedance; D005069:Evaluation Studies as Topic; D005110:Extracellular Space; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D014883:Water-Electrolyte Imbalance / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology