Hemoperfusion with a new anion exchange resin corrects the metabolic alkalosis in pyloric stenosis: an experimental demonstration.
An experimental model of hypertrophic pyloric stenosis was made by suture of the pyloric wall and gastrostomy in 10 rabbits under general anesthesia. Blood sampling indicated severe alkalosis and hypochloremia 3h 30 min after surgery. To correct the derangement, we tested an ion exchange resin (Dowex SAR), coated with a methacrylic hydrogel. A cartridge containing 18 g of this resin was inserted in an extracorporeal circuit. This chloride charged resin achieved uptake of HCO3- ions, and elution of Cl- ions. The electrolytic balance was fully restored after 10 min of treatment.
Faenza
S
S
Anaesthesiology Institute, S. Orsola Hospital, Bologna, Italy.
Balestri
M
M
Martinelli
G
G
Spighi
M
M
Fini
M
M
Giardino
R
R
Colì
L
L
Cianciolo
G
G
Stefoni
S
S
Bonomini
V
V
D000471:Alkalosis / Q000097:blood / Q000209:etiology / Q000628:therapy*; D000818:Animals; D000837:Anion Exchange Resins; D001639:Bicarbonates / Q000097:blood; D002712:Chlorides / Q000097:blood*; D004195:Disease Models, Animal; D004573:Electrolytes / Q000097:blood; D006464:Hemoperfusion; D006863:Hydrogen-Ion Concentration; D008689:Methacrylates; D011707:Pyloric Stenosis / Q000097:blood / Q000150:complications*; D011817:Rabbits
D000837:Anion Exchange Resins; D001639:Bicarbonates; D002712:Chlorides; D004573:Electrolytes; D008689:Methacrylates