Development of alloanti-Jka in a patient with hemolytic anemia due to autoanti-Jkb.
Autoanti-Jkb and a transient autoanti-E were identified in a patient with autoimmune hemolytic anemia, and red blood cells negative for Jkb and E antigens were transfused. Twelve weeks after transfusion, the autoantibody appeared to have developed broad specificity. However, autoadsorption studies revealed that the broad reactivity was due to the development of alloanti-Jka in addition to the autoanti-Jkb. Distinguishing this combination of alloanti-Jka plus autoanti-Jkb from an autoantibody with broad specificity will be important in selecting Jka antigen-negative red cells for subsequent transfusions. This case emphasizes the importance of additional serologic testing to detect alloantibodies in patients with broadly reactive warm autoantibodies.
Grishaber
J E
JE
Department of Pathology, University of Iowa College of Medicine, Iowa City 52242.
Cordle
D G
DG
Strauss
R G
RG
D000328:Adult; D000743:Anemia, Hemolytic / Q000097:blood* / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000097:blood* / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007518:Isoantibodies / Q000032:analysis*; D007667:Kidd Blood-Group System / Q000276:immunology*
D001323:Autoantibodies; D007518:Isoantibodies; D007667:Kidd Blood-Group System