Association of dry eyes and dry mouth with anti-Ro/SS-A and anti-La/SS-B autoantibodies in normal adults.
OBJECTIVE
To evaluate the extent to which seemingly healthy, mature adults with mild symptoms of dry eyes or dry mouth share the immunologic features found in patients with Sjögren's syndrome.


METHODS
Of 705 subjects in Malmö, Sweden (age range 52-72 years) who responded to a questionnaire, 35% reported some symptoms of dry eyes or mouth. A random subgroup of the symptomatic subjects (n = 77) and an age- and sex-matched control group from among the asymptomatic subjects (n = 32) were evaluated objectively by serologic testing and by various measures of exocrine gland function.


RESULTS
The symptomatic subjects had relatively impaired exocrine gland function and elevated levels of anti-Ro and anti-La (1.54-2.88-fold increase compared with the asymptomatic subjects, 95% confidence interval [CI] 1.41, 4.03). The 2 autoantibodies correlated with each other (r = 0.64, 95% CI 0.49, 0.78) as well as with selected clinical measures of glandular function.


CONCLUSIONS
The association between self-reported symptoms of dry eyes or dry mouth and anti-Ro and anti-La, found in more than one-third of mature adults in this study, suggests that the immune abnormalities and exocrine gland dysfunction found in Sjögren's syndrome affect a substantial proportion of the general population.
Jacobsson
L
L
Department of Medicine, Malmö General Hospital, Sweden.
Hansen
B U
BU
Manthorpe
R
R
Hardgrave
K
K
Neas
B
B
Harley
J B
JB
D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis* / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis* / Q000276:immunology; D015331:Cohort Studies; D015352:Dry Eye Syndromes / Q000453:epidemiology / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D005779:Immunodiffusion; D008297:Male; D008875:Middle Aged; D012217:Rheumatoid Factor / Q000032:analysis / Q000276:immunology; D011795:Surveys and Questionnaires; D014987:Xerostomia / Q000453:epidemiology / Q000276:immunology*
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; C035356:SS-A antibodies; C035357:SS-B antibodies; D012217:Rheumatoid Factor