Effects of nefiracetam, DM-9384 on amnesia and decrease in choline acetyltransferase activity induced by cycloheximide.
The effects of nefiracetam, [N-(2,6-dimethyl-phenyl)-2-(2-oxo-pyrrolidinyl)acetamide, DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre-training administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. It protected against CXM-induced inhibition of choline acetyltransferase activity in the cerebral cortex. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with AChergic neuronal system and enhancing protein synthesis in the brain.
Shiotani
T
T
Tokyo Research and Development Center, Daiichi Pharmaceutical Co. Ltd., Japan.
Tohyama
K
K
Murase
K
K
Ishihara
S
S
Kameyama
T
T
Yamasaki
T
T
Hatanaka
S
S
Kojima
H
H
Takasu
Y
Y
Nabeshima
T
T
D000647:Amnesia / Q000139:chemically induced / Q000201:enzymology / Q000503:physiopathology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001921:Brain / Q000201:enzymology; D002795:Choline O-Acetyltransferase / Q000037:antagonists & inhibitors*; D003513:Cycloheximide / Q000494:pharmacology*; D008297:Male; D051379:Mice; D011619:Psychotropic Drugs / Q000494:pharmacology; D011760:Pyrrolidinones / Q000494:pharmacology*
D011619:Psychotropic Drugs; D011760:Pyrrolidinones; C058876:nefiracetam; D003513:Cycloheximide; D002795:Choline O-Acetyltransferase