title: Regional accumulation of amyloid beta/A4 protein precursor in the gerbil brain following transient cerebral ischemia.
abstract: Alterations of beta/A4 amyloid protein precursor (APP) were investigated immunohistochemically in the gerbil brain after transient global ischemia and subsequent reperfusion. Marked accumulation of this protein peaking at 24 h occurred in the neurons of the CA3 and paramedian region of the hippocampus as well as layers III, V and VI of the cerebral cortex. On the contrary, the accumulation was not observed in the neurons of the CA1 region. These results indicate that distribution of APP is altered depending on tissue viabilities after cerebral ischemia.
authors: Department of Neurology, Kyoto University Hospital, Japan.
authors: H
authors: H
authors: Wakita
authors: H
authors: H
authors: Tomimoto
authors: I
authors: I
authors: Akiguchi
authors: K
authors: K
authors: Ohnishi
authors: S
authors: S
authors: Nakamura
authors: J
authors: J
authors: Kimura
mesh_terms: D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D000818:Animals; D001923:Brain Chemistry / Q000502:physiology*; D005849:Gerbillinae; D007150:Immunohistochemistry; D002546:Ischemic Attack, Transient / Q000378:metabolism*; D008297:Male; D015854:Up-Regulation / Q000502:physiology
chemical_list: D016564:Amyloid beta-Protein Precursor