Effectivity and safety of mannitol treatment for acute hepatic failure in rats.
In rats with D-galactosamine-induced hepatic failure, 14C-D-mannitol transport into the brain was accelerated through an increase of vesicular transport via the blood-brain barrier and thus brain mannitol contents increased. However, the osmolarity of the brain tissue changed little and the mortality was decreased by mannitol infusion to acute hepatic-failure rats. Experimental data indicate the effectivity and safety of hypertonic mannitol therapy for cerebral edema in acute hepatic failure.
Watanabe
A
A
Department III of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan.
Tsuchida
T
T
Shiota
T
T
Tominaga
S
S
D000818:Animals; D001692:Biological Transport; D001812:Blood-Brain Barrier / Q000502:physiology; D001834:Body Water; D001921:Brain / Q000378:metabolism; D001929:Brain Edema / Q000188:drug therapy / Q000378:metabolism; D004195:Disease Models, Animal; D005688:Galactosamine; D017114:Liver Failure, Acute / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D008353:Mannitol / Q000493:pharmacokinetics* / Q000627:therapeutic use; D009994:Osmolar Concentration; D051381:Rats; D017207:Rats, Sprague-Dawley; D015996:Survival Rate
D008353:Mannitol; D005688:Galactosamine