title: Opportunities and limits in creating new enzymes. Experiences with the NAD-dependent lactate dehydrogenase frameworks of humans and bacteria.
authors: Molecular Recognition Center, University of Bristol, School of Medical Sciences, United Kingdom.
authors: H M
authors: HM
authors: Wilks
authors: A
authors: A
authors: Cortes
authors: D C
authors: DC
authors: Emery
authors: D J
authors: DJ
authors: Halsall
authors: A R
authors: AR
authors: Clarke
authors: J J
authors: JJ
authors: Holbrook
mesh_terms: D000494:Allosteric Regulation; D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry; D001665:Binding Sites; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000737:chemistry*; D008291:Malate Dehydrogenase / Q000737:chemistry; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D015202:Protein Engineering / Q000379:methods*; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
chemical_list: D001426:Bacterial Proteins; D009243:NAD; D009249:NADP; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase