[Dependence of the initial stages of the pentose phosphate cycle on vitamin C metabolism in connective tissue pathology].
Correlation between rates of oxidative and non-oxidative steps of the pentose phosphate pathway and vitamin C concentration was studied in experimental diffuse impairment of connective tissue. As compared with transketolase, activity of glucose-6-phosphate dehydrogenase was more closely dependent on concentration of ascorbic acid. Content of vitamin C was considerably altered in tissues thus demonstrating profound deterioration of vitamin C metabolism under these conditions. Simultaneous impairment of the pentose phosphate pathway primary steps and of vitamin C metabolism appear to be responsible for initiation of the diffuse injury of the connective tissue.
Prosol'naia
N I
NI
D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism*; D003240:Connective Tissue Diseases / Q000378:metabolism*; D008297:Male; D010427:Pentose Phosphate Pathway; D051381:Rats; D017208:Rats, Wistar
D001205:Ascorbic Acid
Zavisimost' nachal'nykh étapov pentozofosfatnogo tsikla ot obmena vitamina C pri patologii soedinitel'noĭ tkani.