title: Experimental simvastatin-induced myopathy in rabbits.
abstract: We induced experimental myopathy in rabbits by giving simvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor. After oral administration of simvastatin (50 mg/kg/day) for 2 weeks, serum CK was elevated in 5 of 7 rabbits; degenerating or necrotic fibers were seen in 3 rabbits. Using electromyography, myotonic discharges were found in the 2 rabbits examined. The combination of myotonic discharges, necrosis and raised serum CK levels suggests that the myopathy was induced by lesions of the muscle surface membrane.
authors: Third Department of Internal Medicine, Kagoshima University School of Medicine, Japan.
authors: K
authors: K
authors: Nakahara
authors: M
authors: M
authors: Kuriyama
authors: H
authors: H
authors: Yoshidome
authors: K
authors: K
authors: Nagata
authors: T
authors: T
authors: Nagado
authors: M
authors: M
authors: Nakagawa
authors: K
authors: K
authors: Arimura
authors: I
authors: I
authors: Higuchi
authors: M
authors: M
authors: Osame
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004576:Electromyography; D004798:Enzymes / Q000097:blood; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008055:Lipids / Q000097:blood; D008148:Lovastatin / Q000031:analogs & derivatives*; D008297:Male; D009132:Muscles / Q000473:pathology / Q000503:physiopathology; D009135:Muscular Diseases / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D011817:Rabbits; D019821:Simvastatin
chemical_list: D004798:Enzymes; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008055:Lipids; D008148:Lovastatin; D019821:Simvastatin