The effect of antimicrobial impregnation on vascular graft healing. An experimental porcine study.
This study evaluates the impregnation of a phenol derivative (Y105) to polymerized Dacron grafts. Y-105 has broad spectrum anti-microbial characteristics. The grafts were inserted end to side in the iliac artery of pigs. Reexploration and graft removal was performed after 7, 14 and 30 days. After pressure fixation with glutaraldehyde the grafts were evaluated for gross morphology and by scanning electron microscopy. A gradual development of pseudo-intima was observed without sign of graft occlusion. The addition of the antimicrobial impregnation did not interfere with healing.
Pärsson
H
H
Department of Surgery and Structural Zoology, Lund University, Sweden.
Jundzill
W
W
Hallberg
E
E
Norgren
L
L
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001807:Blood Vessel Prosthesis / Q000009:adverse effects*; D004730:Endothelium, Vascular / Q000473:pathology; D007083:Iliac Artery / Q000473:pathology / Q000601:surgery; D008855:Microscopy, Electron, Scanning; D010636:Phenols / Q000494:pharmacology*; D011093:Polyethylene Terephthalates; D011474:Prosthesis Design; D016459:Prosthesis-Related Infections / Q000473:pathology / Q000517:prevention & control*; D013499:Surface Properties; D013552:Swine; D014945:Wound Healing / Q000187:drug effects*
D000890:Anti-Infective Agents; D010636:Phenols; D011093:Polyethylene Terephthalates; C079256:Y 105