The fibrinolytic system and proteins C and S in treated polycythaemia rubra vera.
This study was designed to assess whether factors other than high haemoglobin, thrombocytosis and abnormal platelet function predispose to thrombosis in polycythaemia rubra vera (PRV). Components of the fibrinolytic system and concentrations of the naturally occurring anticoagulants were measured in patients and controls in the resting state; the fibrinolytic capacity was reassessed after venous occlusion. The results were related to presence or absence of a history of thromboembolism. Under resting conditions, patients with PRV had reduced plasminogen activator inhibitor antigen levels and higher fibrin plate lysis area and tissue plasminogen activator activity. Protein C, protein S and factor V levels were reduced. Those patients with a history of thromboembolism had decreased tissue plasminogen activator activity after venous occlusion compared to those who had not experienced a thrombosis. We conclude that reduced fibrinolytic capacity may predispose to thrombosis in PRV. Despite treatment to normalize haemoglobin levels, the patients have persistent activation of their fibrinolytic systems. This, and reduced levels of proteins C and S, may be secondary to a chronic, clinically occult, disseminated intravascular coagulation.
Wieczorek
I
I
Department of Haematology, Royal Infirmary of Edinburgh, Scotland.
MacGregor
I R
IR
Prescott
R J
RJ
Ludlam
C A
CA
D000328:Adult; D000368:Aged; D001772:Blood Cell Count; D001779:Blood Coagulation Factors / Q000032:analysis; D001780:Blood Coagulation Tests; D005260:Female; D005342:Fibrinolysis; D006400:Hematocrit; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000032:analysis; D011087:Polycythemia Vera / Q000097:blood* / Q000150:complications; D011486:Protein C / Q000032:analysis*; D017293:Protein S / Q000032:analysis*; D013923:Thromboembolism / Q000209:etiology; D010959:Tissue Plasminogen Activator / Q000032:analysis
D001779:Blood Coagulation Factors; D017395:Plasminogen Activator Inhibitor 1; D011486:Protein C; D017293:Protein S; D010959:Tissue Plasminogen Activator