Urinary excretion of 3,4-dimethylhippuric acid in workers exposed to 1,2,4-trimethylbenzene.
The urinary excretion of 3,4-dimethylhippuric acid (34DMHA), a 1,2,4-trimethylbenzene (124TMB) metabolite, was investigated in workers exposed to 124TMB vapor. The time-weighted average of exposure to 124TMB was determined with a diffusive sampler. For biological monitoring of exposure, urine samples were collected from individual workers and analyzed for metabolites by high-pressure liquid chromatography. The concentration of urinary 34DMHA had a positive correlation with the level of exposure to 124TMB (r = 0.72). The data suggest that 34DMHA is one of the useful indicators for biological monitoring of 124TMB exposure.
Ichiba
M
M
Department of Community Health Science, Saga Medical School, Japan.
Hama
H
H
Yukitake
S
S
Kubota
M
M
Kawasaki
S
S
Tomokuni
K
K
D000395:Air Pollutants, Occupational / Q000009:adverse effects* / Q000493:pharmacokinetics; D001555:Benzene Derivatives / Q000009:adverse effects* / Q000493:pharmacokinetics; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D004784:Environmental Monitoring; D006626:Hippurates / Q000493:pharmacokinetics*; D006801:Humans; D008452:Maximum Allowable Concentration; D009784:Occupational Diseases / Q000139:chemically induced* / Q000652:urine; D016273:Occupational Exposure / Q000009:adverse effects*
D000395:Air Pollutants, Occupational; D001555:Benzene Derivatives; D006626:Hippurates; C028524:3,4-dimethylhippuric acid; C010313:pseudocumene