title: Comparative in vitro activity of clarithromycin. Spanish Collaborative Group.
abstract: The activity in vitro of clarithromycin, a new macrolide, was compared to that of various antibiotics in tests using 3,880 clinical isolates. Clarithromycin was two times more active than erythromycin against Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, streptococci of groups C, G and F, Brucella melitensis, Legionella pneumophila and Mycoplasma spp., 16 times more active against Ureaplasma urealyticum and 2 to 4 times less active against Campylobacter spp. In general, clarithromycin showed intrinsic activity 2 to 4 times higher than that of roxithromycin and 4 to 8 times higher than that of miocamycin. Cross-resistance was found between the macrolides. Clarithromycin was bactericidal against Streptococcus spp. and Haemophilus influenzae.
authors: Ramón y Cajal Hospital, Department of Microbiology, Madrid, Spain.
authors: E
authors: E
authors: Loza
authors: J
authors: J
authors: Martínez Beltrán
authors: F
authors: F
authors: Baquero
authors: A
authors: A
authors: León
authors: R
authors: R
authors: Cantón
authors: B
authors: B
authors: Garijo
mesh_terms: D017291:Clarithromycin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D004917:Erythromycin; D017291:Clarithromycin