Clinicopathologic studies on leptomeningeal glioneuronal heterotopia in congenital anomalies.
Leptomeningeal glioneuronal heterotopia was observed in 40 of 129 autopsied infants (31%). It was present in 49% of patients who had congenital anomalies in general and in 65% of patients who had central nervous system malformations. Most of the leptomeningeal glioneuronal heterotopias appeared in the base of the brain (62.5%), midbrain (40%), frontal lobe (37%), and pons (35%). Leptomeningeal glioneuronal heterotopia is closely related to migration disorders on the basis of frequent association with polymicrogyria or neuronal heterotopias.
Hirano
S
S
Division of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, Tokyo, Japan.
Houdou
S
S
Hasegawa
M
M
Kamei
A
A
Takashima
S
S
D001921:Brain / Q000473:pathology; D002828:Choristoma / Q000151:congenital* / Q000473:pathology; D000013:Congenital Abnormalities / Q000473:pathology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000473:pathology*; D008577:Meningeal Neoplasms / Q000151:congenital* / Q000473:pathology; D008578:Meninges / Q000473:pathology; D009457:Neuroglia; D009474:Neurons; D013116:Spinal Cord / Q000473:pathology