[Multimodal management of bone sarcomas in children].
Osteogenic sarcoma and Ewing's sarcoma are the most common malignant bone tumors in childhood and adolescence. Marked improvement in prognosis and long-term survival have been achieved using combined modality protocols. We present a retrospective analysis of our experience with combined therapy of malignant bone tumors in children. Among 20 (ranging in age from 6-16, mean 11.4 years) with Ewing's sarcoma, 14 (70%) had complete remission by the end of treatment, 5 (25%) had partial response and 1 did not respond. The overall 10-year actuarial survival was 64%. Of the 10 with osteogenic sarcoma, 5 (50%) fully responded and are alive, 4 (40%) died after a partial or no response and 1 is receiving second-line therapy after partial response to primary treatment. The 10-year actuarial survival was 37.5% and the efficacy of combined modality therapy was demonstrated. However, further efforts are needed to arrive at optimal treatment for improved outcome.
Ben-Arush
M
M
Northern Israel Oncology Center, Haifa.
Rosenblatt
E
E
Kuten
A
A
Meler
I
I
Bialik
V
V
Stein
M
M
D000206:Actuarial Analysis; D000293:Adolescent; D001859:Bone Neoplasms / Q000401:mortality / Q000628:therapy*; D002648:Child; D003131:Combined Modality Therapy; D006801:Humans; D012516:Osteosarcoma / Q000401:mortality / Q000628:therapy*; D012074:Remission Induction; D012189:Retrospective Studies; D012512:Sarcoma, Ewing / Q000401:mortality / Q000628:therapy*; D015996:Survival Rate