title: Amino acids and peptides. XXXV. Synthesis of mouse metallothionein I. (2). Synthesis of a nonacosapeptide corresponding to N-terminal sequence 1-29 (beta-fragment) of mouse metallothionein I and related peptides and examination of their heavy metal-binding properties.
abstract: A nonacosapeptide corresponding to the N-terminal sequence 1-29 (beta-fragment) of mouse metallothionein I and related peptides were synthesized by the conventional solution method and their heavy metals (Cu2+, Cu+ and Cd2+)-binding properties were examined. The Cu(2+)- or Cu(+)-binding activities of various peptides were not greatly dependent on the peptide structure, so far as examined, as in the cases of N. crassa MT and A. bisporus MTs. On the contrary, the Cd(2+)-binding activities of these peptides were fairly structure-dependent.
authors: Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Japan.
authors: S
authors: S
authors: Matsumoto
authors: Y
authors: Y
authors: Nishiyama
authors: Y
authors: Y
authors: Okada
authors: K S
authors: KS
authors: Min
authors: S
authors: S
authors: Onosaka
authors: K
authors: K
authors: Tanaka
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D008668:Metallothionein / Q000737:chemistry*; D051379:Mice; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000737:chemistry*; D011485:Protein Binding
chemical_list: D010446:Peptide Fragments; D008668:Metallothionein