title: Selective dopamine transporter inhibition by cocaine analogs.
abstract: Several isopropyl and phenyl esters of 3 beta-(4-substituted phenyl) tropan-2 beta-carboxylic acid analogs of cocaine are relatively more potent and selective than cocaine and some other compounds in inhibiting dopamine uptake. These analogs can be used as binding ligands and as tools for elucidating the mechanisms of action of cocaine.
authors: Laboratory of Molecular Pharmacology, National Institute on Drug Abuse, Addiction Research Center, Baltimore, MD 21224.
authors: J W
authors: JW
authors: Boja
authors: R M
authors: RM
authors: McNeill
authors: A H
authors: AH
authors: Lewin
authors: P
authors: P
authors: Abraham
authors: F I
authors: FI
authors: Carroll
authors: M J
authors: MJ
authors: Kuhar
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D003042:Cocaine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D050483:Dopamine Plasma Membrane Transport Proteins; D008024:Ligands; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D008024:Ligands; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D012701:Serotonin; D003042:Cocaine; D004298:Dopamine; D009638:Norepinephrine