title: Immunomodulatory activity of various fractions derived from Physalis angulata L extract.
abstract: The immunomodulatory effects of Physalis angulata L. extract fraction VII (PA-VII), PA-VII-A, PA-VII-B and PA-VII-C were investigated in this study. The results showed that PA-VII and PA-VII-C strongly enhanced blastogenesis response, PA-VII-B had moderate activity, and PA-VII-A exerted only slight effect on cell proliferation. A synergistic effect was observed when the suboptimal dosage of phytohemagglutinin (PHA) or lipopolysaccharide (LPS) was added to the culture. Furthermore, PA-VII and PA-VII-C possessed stimulatory activity on B cells and less effect on T cells. The antibody responses were also augmented by PA-VII, PA-VII-B and PA-VII-C, but not by PA-VII-A. The enhancement of antibody response could be observed both in BALB/c and C3H/HeJ mice.
authors: Department of Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan.
authors: Y S
authors: YS
authors: Lin
authors: H C
authors: HC
authors: Chiang
authors: W S
authors: WS
authors: Kan
authors: E
authors: E
authors: Hone
authors: S J
authors: SJ
authors: Shih
authors: M H
authors: MH
authors: Won
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000145:classification / Q000276:immunology*; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000145:classification / Q000494:pharmacology*; D007783:Lactones / Q000737:chemistry / Q000145:classification / Q000276:immunology*; D008070:Lipopolysaccharides / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D010835:Phytohemagglutinins / Q000276:immunology; D012632:Secosteroids; D013256:Steroids
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D007783:Lactones; D008070:Lipopolysaccharides; D010835:Phytohemagglutinins; D012632:Secosteroids; D013256:Steroids; C075425:physalin F