[Changes in the blood serum lipids and lipoproteins of rats in ovariectomy and to the administration of the methyl ester of 6-hydroxy-D-homo-8-isoestrone].
Ovariectomy of rats resulted in biphasic increase of the blood plasma cholesterol (on days 42-54, 70), the alteration of lipoprotein spectrum. The administration to ovariectomized rats of methyl ether 6-oxy-D-homo-8-isoestrone in a dose of 0.01 mg/kg brought about lowering of serum cholesterol and normalization of lipoproteins spectrum. The above trends were not observed after introduction of 0.01 mg/kg estradiol.
Kameneva
I Iu
IIu
Shavva
A G
AG
Lozovskiĭ
V G
VG
Ryzhenkov
V E
VE
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004970:Estrone / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006718:Homosteroids; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood* / Q000187:drug effects*; D010052:Ovariectomy; D010053:Ovary / Q000502:physiology*; D051381:Rats
D006718:Homosteroids; D008055:Lipids; D008074:Lipoproteins; C078799:6-hydroxy-D-homo-8-isoestrone methyl ether; D004970:Estrone
Izmeneniia lipidov i lipoproteinov syvorotki krovi krys pri ovariéktomii i vvedenii metilovogo éfira 6-oksi-D-gomo-8-izoéstrona.