[Effects of pyrazidol on resistance of animals to hypobaric hypoxia].
The influence of monoamine oxidase type A inhibitor pyrazidol on rats sensitivity to hypobaric hypoxia was investigated. Preliminary pyrazidol administration shows evident protective effect under hypoxia. It increases animals survival at the altitude of 12,000 m above the sea level, prevents lungs affection and erythrocyte membrane destabilization at the altitude of 9,000 m during 3 hours. Plasma total peroxidase activity, extraerythrocyte hemoglobin concentration and free iron content were used as the indexes of erythrocyte membrane stability reflecting the organism state under stress effects.
Goroshinskaia
I A
IA
Nemashkalova
L A
LA
Khodakova
A A
AA
Sherstnev
K B
KB
D000532:Altitude Sickness / Q000517:prevention & control*; D000818:Animals; D001274:Atmospheric Pressure; D002227:Carbazoles / Q000494:pharmacology*; D004910:Erythrocyte Membrane; D006454:Hemoglobins / Q000032:analysis; D000860:Hypoxia / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D007501:Iron / Q000097:blood; D008171:Lung Diseases / Q000517:prevention & control; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D010544:Peroxidases / Q000097:blood; D051381:Rats
D002227:Carbazoles; D006454:Hemoglobins; D008996:Monoamine Oxidase Inhibitors; D007501:Iron; D010544:Peroxidases; C009830:pirlindole
Vliianie pirazidola na ustoĭchivost' zhivotnykh k gipobaricheskoĭ gipoksii.