[Hematopoietic precursor cells in radiation chimeras restored by bone marrow from thymectomized mice].
Radioprotective capacity of bone marrow CFUs of adult thymectomized mice was studied. Lethally irradiated mice were inoculated with bone marrow of mice thymectomized 8-11 months before. The colony forming capacity and proliferative rate of CFUs were studied 1-7.5 months after obtaining the radiation chimeras. It has been shown that proliferative capacity of bone marrow of adult thymectomized mice was reduced in comparison with that of normal animals. It is related to the decrease (4-fold) of the proliferative rate of bone marrow of thymectomized mice which was inoculated into lethally irradiated recipients 1 month before. We also found that the content of CFUs in bone of those chimeras was reduced later--after 7.5 months. In this period (1-7.5 months) the cellularity of bone marrow did not change.
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D000818:Animals; D016026:Bone Marrow Transplantation / Q000276:immunology*; D002455:Cell Division / Q000276:immunology / Q000528:radiation effects; D002588:Cesium Radioisotopes; D003114:Colony-Forming Units Assay; D005260:Female; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology* / Q000528:radiation effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011828:Radiation Chimera / Q000276:immunology*; D013934:Thymectomy; D013950:Thymus Gland / Q000276:immunology*; D013997:Time Factors
D002588:Cesium Radioisotopes
Krovetvornye kletki-predshestvenniki u radiatsionnykh khimer, vosstanovlennykh kostnym mozgom timéktomirovannykh mysheĭ.