title: [Prooxidant effect of inflammation mediators].
abstract: The authors studied the effect of inflammation mediators--serotonin, histamine, bradykinin, as well as that of trypsin on lipid peroxidation (LPO). It was demonstrated by chemiluminescence of native hepatic mitochondria in vitro and blood serum in vivo and tests for diene conjugates and malonic dialdehyde that inflammation mediators (histamine, serotonin, bradykinin) and the proteolytic enzyme trypsin activate LPO processes, which correlates with the antiinflammatory effect of these biologically active substances.
authors: Kh M
authors: KhM
authors: Nasyrov
authors: R M
authors: RM
authors: Kondratenko
mesh_terms: D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D005260:Female; D006632:Histamine / Q000494:pharmacology*; D066298:In Vitro Techniques; D007249:Inflammation / Q000188:drug therapy*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000494:pharmacology*; D014357:Trypsin / Q000494:pharmacology*
chemical_list: D012701:Serotonin; D006632:Histamine; D014357:Trypsin; D001920:Bradykinin
vernacular_title: K prooksidantnomu deĭstviiu mediatorov vospaleniia.