Thymic selection: a matter of life and death.
Mice transgenic for the T-cell receptor (TCR) were instrumental to the understanding that developing alpha beta T cells undergo programmed cell death unless the TCR beta gene properly rearranges and produces receptors of appropriate specificity. The delineation of developmental pathways for 'conventional' alpha beta T cells has resulted in the recognition of a different lineage of alpha beta T cells that develop in the thymus, the function of which remains to be elucidated.
von Boehmer
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Basel Institute for Immunology, Switzerland.
D000818:Animals; D017209:Apoptosis / Q000235:genetics; D017252:CD3 Complex / Q000096:biosynthesis; D015704:CD4 Antigens / Q000096:biosynthesis; D015329:Gene Rearrangement, T-Lymphocyte; D006031:Glycosylation; D008024:Ligands; D051379:Mice; D008822:Mice, Transgenic / Q000276:immunology; D008954:Models, Biological; D011499:Protein Processing, Post-Translational; D011948:Receptors, Antigen, T-Cell / Q000096:biosynthesis* / Q000235:genetics; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000096:biosynthesis / Q000235:genetics; D012641:Selection, Genetic; D016176:T-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology*
D017252:CD3 Complex; D015704:CD4 Antigens; D008024:Ligands; D011948:Receptors, Antigen, T-Cell; D016693:Receptors, Antigen, T-Cell, alpha-beta