[The protective effect of carnosine in hypoxia and reoxygenation of the isolated rat heart].
The effect of carnosine (15 mM) on the contractile activity of isolated rat hearts contracting in an isotonic regime (37 degrees C at a 5 Hz stimulation frequency) has been studied. Carnosine added to the perfusing solution had no effect on the contractile activity either in hypoxia or during reoxygenation but decreased it with a simultaneous increase in the coronary flow during reoxygenation. Carnosine inhibited by 60% the lactate dehydrogenase release from cardiac cells. A conclusion is drawn that the protective effect of carnosine is due to its membrane-stabilizing action which is implemented during inhibition of peroxidation of membrane lipids.
Prokop'eva
V D
VD
Laptev
B I
BI
Afanas'ev
S A
SA
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002336:Carnosine / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D000860:Hypoxia; D066298:In Vitro Techniques; D015227:Lipid Peroxidation; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D009200:Myocardial Contraction; D010100:Oxygen; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D008563:Membrane Lipids; D002336:Carnosine; D010100:Oxygen
Zashchitnoe deĭstvie karnozina pri gipoksii i reoksigenatsii izolirovanogo serdtsa krysy.