Effects of age and size on development of allodynia in a chronic pain model produced by sciatic nerve ligation in rats.
Sciatic nerve constriction injury in rats has been used by various investigators as a model of chronic pain exhibiting allodynia and hyperalgesia. Although rats ranging between 200 and 350 g (40-70 days old) at the time of operation have been used by various investigators, the effect of rat age and weight on the model has not been previously studied. We noted that a group of older rats failed to develop all the characteristics of the model and designed the present study to determine the effect of age and weight on the development of allodynia and hyperalgesia. Three groups of rats varying in age (54, 71, and 107 days) and weight (220-250 g, 270-350 g, and 370-470 g) with the experimental lesion were tested for hyperalgesia, cold allodynia, and tactile allodynia. We found that although the degree of hyperalgesia of all groups was the same, the oldest group had significantly longer response latencies to allodynia tests than the younger 2 groups. Responses to the cold test were no different than control in the oldest group. The results of the present study demonstrate that larger, older rats fail to develop allodynia after sciatic nerve ligation.
Tanck
Erik N
EN
Department of Anesthesiology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612 USA Department of Neurosurgery, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612 USA.
Kroin
Jeffrey S
JS
McCarthy
Robert J
RJ
Penn
Richard D
RD
Ivankovich
Anthony D
AD
D000375:Aging / Q000523:psychology*; D000818:Animals; D001835:Body Weight / Q000502:physiology*; D002908:Chronic Disease; D003080:Cold Temperature; D004195:Disease Models, Animal; D008297:Male; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000502:physiology*; D012879:Skin Physiological Phenomena