Levels of cyclosporin-A (CsA) in saliva in children after oral administration of the drug in mixture or in capsule form.
The cyclosporin-A (CsA) level in human unstimulated whole saliva was studied in 5 children, aged 9-16 yr, receiving the immunosuppressive drug CsA following renal allograft transplantation. The time-concentration relationship of CsA in saliva was determined in the children who were taking the drug orally in mixture form (n = 3) as well as in capsule form (n = 3). For the mixture, the median maximal level of CsA in whole saliva was 2867 ng/ml compared to 5.4 ng/ml for the capsule. The oral mucosal exposure of CsA during the dosage interval was approximately 130 times higher when the drug was administered in mixture form than in capsule form. The study demonstrates that gingival tissue is exposed to a considerable concentration of CsA throughout the dosage interval in patients taking CsA in mixture form. Therefore the vehicle in which the drug is administered should be considered in the pathogenesis of CsA-induced gingival overgrowth.
Modéer
T
T
Department of Pedodontics, Faculty of Odontology, Huddinge University Hospital, Karolinska Institute, Sweden.
Wondimu
B
B
Larsson
E
E
Jonzon
B
B
D000284:Administration, Oral; D000293:Adolescent; D002214:Capsules; D002648:Child; D016572:Cyclosporine / Q000008:administration & dosage* / Q000032:analysis* / Q000097:blood / Q000627:therapeutic use; D003774:Dental Plaque Index; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D000069463:Olive Oil; D010512:Periodontal Index; D010938:Plant Oils; D012463:Saliva / Q000737:chemistry*; D012715:Sesame Oil; D013997:Time Factors
D002214:Capsules; D000069463:Olive Oil; D010938:Plant Oils; D012715:Sesame Oil; D016572:Cyclosporine