[Superoxide dismutase activity in the broncho-alveolar lavage fluid in late asthmatic response model in guinea pigs].
In order to investigate the mechanism of the late asthmatic responses (LAR), LAR model in guinea pigs was made by inhalation of a large quantity of egg albumin antigen. Serial changes of inflammatory cells and superoxide dismutase activities in broncho-alveolar lavage fluids obtained from these animals were observed. In this model, increase in inflammatory cells, such as neutrophils, was observed in the broncho-alveolar lavage fluid during the late asthmatic responses of the attack and superoxide dismutase activity increased in the broncho-alveolar lavage fluid in parallel with the increase in inflammatory cells. These results suggest that change in superoxide dismutase activity in the broncho-alveolar lavage fluid may be involved in the onset of the late asthmatic responses.
Inagaki
M
M
First Department of Internal Medicine, Gunma University School of Medicine, Japan.
Nakazawa
T
T
D000818:Animals; D001249:Asthma / Q000201:enzymology / Q000209:etiology*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology / Q000201:enzymology*; D002452:Cell Count; D004195:Disease Models, Animal; D006168:Guinea Pigs; D008297:Male; D009504:Neutrophils; D013482:Superoxide Dismutase / Q000378:metabolism*
D013482:Superoxide Dismutase