Transferrin synthesis by macrophages: up-regulation by gamma-interferon and effect on lymphocyte proliferation.
We have investigated transferrin synthesis by human and mouse lymphoid and myeloid cells. It was found that transferrin synthesis is a property of mouse but not human macrophages, whereas in man T lymphocytes synthesised transferrin. Synthesis by mouse macrophages showed a dose-dependent increase in response to gamma-interferon (gamma-IFN), but iron added as ferric nitrilotriacetate had no effect. Macrophage-derived transferrin was found to contain iron already bound to it and was able to support Con A-stimulated mouse lymphocyte proliferation.
Djeha
A
A
Department of Immunology, Western Infirmary, Glasgow, UK.
Pérez-Arellano
J L
JL
Hayes
S L
SL
Brock
J H
JH
D000818:Animals; D002460:Cell Line; D005290:Ferric Compounds / Q000494:pharmacology; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D008264:Macrophages / Q000378:metabolism*; D016676:Macrophages, Alveolar / Q000378:metabolism*; D051379:Mice; D009571:Nitrilotriacetic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D014168:Transferrin / Q000096:biosynthesis*; D015854:Up-Regulation
D005290:Ferric Compounds; D014168:Transferrin; D007371:Interferon-gamma; D009571:Nitrilotriacetic Acid; C020326:ferric nitrilotriacetate