Activity of superoxide dismutase isoenzymes in the bone marrow of irradiated rabbits.
The activities of total, Cu,Zn- and Mn-containing superoxide dismutase were studied in the bone marrow of whole-body irradiated rabbits with 6.0 Gy or 24.0 Gy with local shielding. Irradiation with 6.0 Gy depressed the activities of total and Cu,Zn-SOD on the 8th and 15th days, whereas the activity of Mn-SOD did not change. The exposure to 24.0 Gy with local shielding of head and abdominal region decreased Cu,Zn-SOD activity on the 4th and 60th days after irradiation, Mn-SOD activity was lower nearly at all time intervals investigated. The exposure to 24.0 Gy with shielding of whole body without head region increased markedly Cu,Zn-SOD activity, whereas Mn-SOD activity was diminished on the 8th and 15th days after irradiation in comparison with control group. Mn-SOD activity (U per 10(6) of bone marrow cells) was increased at early time intervals, the changes were not so striking after irradiation of rabbits with 24.0 Gy with shielding of whole body without head region.
Kovárová
H
H
Department of Biochemistry, Medical Faculty, Charles University, Hradec, Králové.
Stoklasová
A
A
Ledvina
M
M
D000818:Animals; D001853:Bone Marrow / Q000378:metabolism* / Q000528:radiation effects*; D005260:Female; D005720:Gamma Rays; D007527:Isoenzymes / Q000378:metabolism* / Q000528:radiation effects; D011817:Rabbits; D013482:Superoxide Dismutase / Q000378:metabolism* / Q000528:radiation effects
D007527:Isoenzymes; D013482:Superoxide Dismutase