Pharmacokinetics of progesterone in ovariectomized rats after single dose intravenous administration.
The pharmacokinetics of progesterone were characterized in ovariectomized female rats. Progesterone was administered intravenously at a dose of 500 micrograms kg-1. Serum progesterone concentrations were determined by radioimmunoassay. Serum concentrations of progesterone were best described by a two-compartment model with elimination from the central compartment. The distribution and elimination phase half-lives were 0.13 +/- 0.024 (mean +/- SD) and 1.21 +/- 0.21 h, respectively. Elimination of the steroid was rapid with a total clearance of 2.75 +/- 0.42 l h-1 kg-1. Progesterone was widely distributed in the rat with a steady state volume of distribution of 2.36 +/- 0.23 l kg-1, a volume of the central compartment of 0.86 +/- 0.24 l kg-1 and a volume of the peripheral compartment of 1.50 +/- 0.19 l kg-1. The results of this study suggest that the ovariectomized female rat is a suitable animal model for examining the pharmacokinetics of progesterone.
Gangrade
N K
NK
Department of Pharmaceutics, College of Pharmacy, University of Georgia, Athens 30602.
Boudinot
F D
FD
Price
J C
JC
D000818:Animals; D005260:Female; D006207:Half-Life; D007275:Injections, Intravenous; D008657:Metabolic Clearance Rate; D010052:Ovariectomy; D011374:Progesterone / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley
D011374:Progesterone