title: Hypoglycemic activity of olive leaf.
abstract: The hypoglycemic activity of olive leaf was studied. Maximum hypoglycemic activity was obtained from samples collected in the winter months, especially in February. One of the compounds responsible for this activity was oleuropeoside, which showed activity at a dose of 16 mg/kg. This compound also demonstrated antidiabetic activity in animals with alloxan-induced diabetes. The hypoglycemic activity of this compound may result from two mechanisms: (a) potentiation of glucose-induced insulin release, and (b) increased peripheral uptake of glucose.
authors: Departamento de Farmacologia, Facultad de Farmacia, Universidad de Granada, Spain.
authors: M
authors: M
authors: Gonzalez
authors: A
authors: A
authors: Zarzuelo
authors: M J
authors: MJ
authors: Gamez
authors: M P
authors: MP
authors: Utrilla
authors: J
authors: J
authors: Jimenez
authors: I
authors: I
authors: Osuna
mesh_terms: D000818:Animals; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007422:Intestines / Q000187:drug effects; D008297:Male; D010946:Plants, Medicinal; D011714:Pyrans / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014197:Trees
chemical_list: D007004:Hypoglycemic Agents; D011714:Pyrans; C073418:oleuropeoside