Absorption of a nutrient solution in chronic alcoholics without nutrient deficiencies and liver cirrhosis.
Duodenal and jejunal absorption of a nutrient solution at two different caloric loads (1.32 and 3.96 kcal/min = 5.6 and 16.8 kJ/min) was compared in chronic alcoholics without malnutrition, liver cirrhosis, obvious small-bowel dysfunction, and exocrine pancreatic insufficiency and in an age-matched control group, by means of the intestinal perfusion technique. In chronic alcoholics duodenal net absorption of water (p < 0.025), sodium (p < 0.02), potassium (p < 0.005), total nitrogen (p < 0.02), carbohydrates (p < 0.05), and lipids (p < 0.05) was lower than in controls when both caloric loads were administered, but jejunal absorption rates were not decreased. Biliopancreatic secretion did not differ between alcoholics and controls. Higher serum protein leakage in alcoholics was indicated by an increased (p < 0.01) duodenal alpha 1-antitrypsin clearance under low caloric load infusion. It is concluded that the absorptive function of the duodenum is impaired in alcoholics, whereas the upper jejunum is not affected.
Pfeiffer
A
A
2nd Medical Dept., München-Bogenhausen Hospital, Germany.
Schmidt
T
T
Vidon
N
N
Pehl
C
C
Kaess
H
H
D000328:Adult; D000437:Alcoholism / Q000150:complications / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000378:metabolism; D050260:Carbohydrate Metabolism; D002918:Chymotrypsin / Q000378:metabolism; D004386:Duodenum / Q000378:metabolism; D004573:Electrolytes / Q000378:metabolism; D002149:Energy Intake; D005260:Female; D005526:Food, Formulated; D006801:Humans; D007408:Intestinal Absorption; D007583:Jejunum / Q000378:metabolism; D008049:Lipase / Q000378:metabolism; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D009584:Nitrogen / Q000378:metabolism; D009752:Nutritional Status; D014867:Water / Q000378:metabolism; D000515:alpha 1-Antitrypsin / Q000378:metabolism
D001647:Bile Acids and Salts; D004573:Electrolytes; D000515:alpha 1-Antitrypsin; D014867:Water; D008049:Lipase; D002918:Chymotrypsin; D009584:Nitrogen