Neutrophilic intracellular acidosis induced by conventional, lactate-containing peritoneal dialysis solutions.
Exposure of human neutrophils to a conventional, acidic, lactate-containing peritoneal dialysis solution (PDS) resulted in the development of a prompt and substantial intracellular acidosis. It is possible that this intracellular acidosis contributes to cellular dysfunction.
Yu
A W
AW
Department of Medicine, School of Medicine, University of California, Irvine.
Zhou
X J
XJ
Zhou
F Q
FQ
Nawab
Z M
ZM
Gandhi
V C
VC
Ing
T S
TS
Vaziri
N D
ND
D000328:Adult; D002499:Centrifugation, Density Gradient; D015314:Dialysis Solutions / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000009:adverse effects*; D019344:Lactic Acid; D008297:Male; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D010530:Peritoneal Dialysis
D015314:Dialysis Solutions; D007773:Lactates; D019344:Lactic Acid