title: [The evaluation of the mutagenic activity of pertussis vaccinal preparations].
abstract: Two vaccine preparations obtained from Bordetella pertussis, whole-cell vaccine constituting one of the components of adsorbed DPT vaccine and acellular vaccine, were tested for mutagenicity. The doses of the preparations covered the range 1-100 ED50. Ames' test and the metaphase analysis of marrow cells of C57BL/6J mice were used. The acellular preparation was also tested on thymectomized mice, taking into consideration chromosomal aberrations in marrow metaphases. Whole-cell and acellular pertussis vaccines did not induce mutations in Salmonella typhimurium and chromosomal aberrations in mouse marrow cells.
authors: G M
authors: GM
authors: Bolgareva
authors: E K
authors: EK
authors: Krivtsova
authors: Iu A
authors: IuA
authors: Revazova
authors: N S
authors: NS
authors: Zakharova
authors: I G
authors: IG
authors: Bazhanova
authors: T N
authors: TN
authors: Remova
authors: E I
authors: EI
authors: Shmeleva
authors: N U
authors: NU
authors: Mertsalova
authors: E E
authors: EE
authors: Sukhinova
authors: E S
authors: ES
authors: Revazova
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000648:ultrastructure; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D005798:Genes, Bacterial / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016296:Mutagenesis / Q000187:drug effects*; D009152:Mutagenicity Tests; D010567:Pertussis Vaccine / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D015164:Vaccines, Inactivated / Q000633:toxicity
chemical_list: D010567:Pertussis Vaccine; D015164:Vaccines, Inactivated
vernacular_title: Otsenka mutagennoĭ aktivnosti kokliushnykh vaktsinal'nykh preparatov.