In vitro activity of Ro 23-9424 against clinical isolates of Legionella species.
Agar and broth microdilution MICs of Ro 23-9424 that inhibited 90% of 22 Legionella clinical isolates tested were 0.64 and 0.08 micrograms/ml, respectively; respective erythromycin values were 1.0 and 0.12 micrograms/ml. Ro 23-9424 (1 microgram/ml) was slightly more active than the same erythromycin concentration in a macrophage system, for both Legionella pneumophila strains studied.
Edelstein
P H
PH
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-4283.
Edelstein
M A
MA
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D015169:Colony Count, Microbial; D003470:Culture Media; D004917:Erythromycin / Q000494:pharmacology; D005110:Extracellular Space / Q000382:microbiology; D016576:Fleroxacin / Q000031:analogs & derivatives* / Q000494:pharmacology; D024841:Fluoroquinolones; D006168:Guinea Pigs; D007424:Intracellular Fluid / Q000382:microbiology; D007875:Legionella / Q000187:drug effects*; D016676:Macrophages, Alveolar / Q000382:microbiology; D008826:Microbial Sensitivity Tests / Q000379:methods
D000890:Anti-Infective Agents; D003470:Culture Media; D024841:Fluoroquinolones; C060441:Ro-23-9424; D004917:Erythromycin; D002439:Cefotaxime; D016576:Fleroxacin