[Allogeneic bone marrow transplantation in myeloid leukemia: chemical conditioning, clinical course and results].
10 patients between the ages of 5 and 40 yrs with myeloid leukemia (4 acute, 6 chronic) in early (5 cases) or intermediate stage of the disease were given Cyclophosphamide and Busulfan (6 cases) or Cyclophosphamide, Busulfan and VP-16 (4 cases with CML) and bone marrow transplants from HLA-matched donors (in 9 cases from siblings and in one case from HLA phenotypically matched father). There was one transplant related death and 3 relapses in CML cases. In cases which relapsed GvHD was not observed. Altogether acute GvH and chronic GvHD was seen in 2 and 4 cases, respectively. All grafted cases with AML survive in continuous remission lasting more than 2 years (median 30.5 month).
Glejzer
O
O
Zespół Przeszczepiania Szpiku Kostnego, Szpital im. Kazimierza Dłuskiego.
Sedzimirska
M
M
Tomaszewska-Toporska
B
B
Tomeczko
J
J
Kołodziej
J
J
Pacuszko
T
T
Was
A
A
Bocheńska
J
J
Jaźwiec
B
B
Klimczak
A
A
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001752:Blast Crisis / Q000150:complications / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000276:immunology / Q000379:methods*; D002066:Busulfan / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000008:administration & dosage*; D005047:Etoposide / Q000008:administration & dosage*; D006082:Graft Enhancement, Immunologic / Q000379:methods*; D006086:Graft vs Host Disease / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D014184:Transplantation, Homologous
D005047:Etoposide; D003520:Cyclophosphamide; D002066:Busulfan
Allogeniczny przeszczep szpiku w białaczkach szpikowych: uwarunkowanie chemiczne przeszczepu, przebieg kliniczny, wyniki.