Elevated levels of plasma and urine beta-thromboglobulin or thromboxane-B2 as markers of real platelet hyperactivation in diabetic nephropathy.
Serum creatinine, immunoreactive serum and urine beta 2-microglobulin, plasma and urine thromboglobulin, plasma thromboxane-B2 levels and daily protein excretion were determined in 61 insulin-treated diabetic patients, comparing the different patient groups (complication free, nephropathy without and with azotaemia) with control subjects. In the groups of diabetic patients, plasma and urine beta-thromboglobulin (BTG) and plasma thromboxane-B2 levels were higher than in the controls. There was a significant positive correlation between urine BTG and beta 2-microglobulin in the group without complication, and between the plasma BTG and beta 2-microglobulin, and plasma BTG and thromboxane levels in the diabetic group with azotaemia. In contrast to some previous assumptions, the increased level of plasma BTG reflects a real platelet hyperactivation in patients with diabetic nephropathy. At the same time, urine BTG also increases. Determination of urine BTG is more simple with less possibility of methodological error.
Tóth
L
L
István City Hospital, 2nd Medical Department, Budapest, Hungary.
Szénási
P
P
Varsányi
M N
MN
Szilvási
I
I
Lehoczky
E
E
Kammerer
L
L
Romics
L
L
D000328:Adult; D015415:Biomarkers; D003404:Creatinine / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D015539:Platelet Activation; D013929:Thromboxane B2 / Q000097:blood*; D001613:beta 2-Microglobulin / Q000378:metabolism; D001620:beta-Thromboglobulin / Q000378:metabolism*
D015415:Biomarkers; D001613:beta 2-Microglobulin; D001620:beta-Thromboglobulin; D013929:Thromboxane B2; D003404:Creatinine