Planning of drug interaction studies involving digoxin treatment: a statistical view.
The most valuable information we obtained from literature research was, that digoxin serum concentrations are generally of primary interest rather than area under curve or maximum concentration. Steady-state plasma levels appeared as a generally accepted endpoint to judge pharmacokinetic interaction. However, time-points for measurements were chosen differently and varied widely. Often, digoxin clearance was also considered. Despite the large amount of data, publications, opinions and single conclusions, no general statement could be made either about what is considered a relevant interaction or what is judged as "no interaction".
Collie
H
H
Focus Clinical Drug Development GmbH, Neuss, Germany.
Wargenau
M
M
D000818:Animals; D004077:Digoxin / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D013223:Statistics as Topic
D004077:Digoxin