Resistance to insulin-induced hyperphagia in fat-preferring rats.
Outbred male Sprague-Dawley rats were screened for their macronutrient (fat, carbohydrate and protein) preference profile and divided into two groups, the low- and high fat-preferring groups each deriving 23% and 72% of its total caloric intake from fat respectively. Subcutaneous administration of bovine insulin (6U/kg) resulted in an increase in total caloric intake in the low, but not the high fat-preferring group. Furthermore, the increased caloric intake in the low fat-preferring group was entirely due to increased carbohydrate consumption. These data suggest a defect in the action of insulin in fat-preferring rats.
Prasad
A
A
Department of Medicine, Louisiana State University Medical Center, New Orleans 70112.
Happel
M
M
Prasad
C
C
D000818:Animals; D002755:Choice Behavior; D004041:Dietary Fats / Q000008:administration & dosage*; D006963:Hyperphagia / Q000139:chemically induced*; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D004041:Dietary Fats