title: Plasma leakage in skin of sheep selected for resistance or susceptibility to fleece rot and fly strike.
abstract: The leakage of plasma into skin following injection of histamine, bradykinin, activated complement, platelet-activating factor and serotonin was measured in sheep bred for resistance or susceptibility to fleece rot and fly strike. Genetically susceptible sheep had significantly greater plasma leakage to activated complement than genetically resistant sheep, and for all mediators there was a trend for plasma leakage to be greater in susceptible sheep. Within each genotype there was also a tendency for plasma leakage to be positively correlated with fleece rot score. In a flock of sheep of different genetic background not selected for resistance or susceptibility to fleece rot and fly strike, positive phenotypic correlations were also noted between fleece rot and plasma leakage. Plasma leakage provides nutrition for the first instar larvae of Lucilia cuprina, the major cause of primary blowfly strike in Australia. Diminished leakage of plasma following release of endogenous permeability mediators may be one component of the mechanism that confers resistance in animals bred for resistance to fleece rot and fly strike.
authors: CSIRO Division of Animal Health, Armidale NSW, Australia.
authors: I G
authors: IG
authors: Colditz
authors: R R
authors: RR
authors: Woolaston
authors: J
authors: J
authors: Lax
authors: S I
authors: SI
authors: Mortimer
mesh_terms: D000818:Animals; D002199:Capillary Permeability / Q000235:genetics / Q000276:immunology; D004198:Disease Susceptibility / Q000276:immunology; D005260:Female; D020022:Genetic Predisposition to Disease; D006201:Hair Diseases / Q000235:genetics / Q000276:immunology / Q000662:veterinary*; D007113:Immunity, Innate / Q000235:genetics / Q000276:immunology; D008297:Male; D009198:Myiasis / Q000235:genetics / Q000276:immunology / Q000662:veterinary*; D010641:Phenotype; D010949:Plasma; D012756:Sheep; D012757:Sheep Diseases / Q000235:genetics / Q000276:immunology*; D012867:Skin / Q000098:blood supply* / Q000469:parasitology