title: Decision to treat mild hypertension after assessment by ambulatory monitoring and World Health Organisation recommendations.
abstract: OBJECTIVE
  To determine if one ambulatory blood pressure recording over 12 hours could detect those patients with mild hypertension who needed treatment according to the World Health Organisation-International Society of Hypertension (ISH) guidelines based on the causal measurement of diastolic blood pressure at successive visits to a clinic.
  
  
  METHODS
  Comparison of decision to treat based on one ambulatory measurement over 12 hours and standard blood pressure measurements over six months in the same patients.
  
  
  METHODS
  Outpatient hypertension clinic.
  
  
  METHODS
  130 men and women with diastolic blood pressure of 90-104 mm Hg at second visit to clinic.
  
  
  METHODS
  Blood pressure measurements over six months. Measurement from ambulatory monitoring. Decision to treat.
  
  
  RESULTS
  Of the 130 patients included, 108 were followed up over the six months. Treatment was started according to WHO-ISH criteria in 44 (13 at the third visit, 13 at the fourth, 18 at the fifth). According to the selected criteria for ambulatory blood pressure monitoring 41 patients would have been treated. Both methods agreed that the same 27 patients required treatment and the same 50 did not, but they did not agree in 31 patients. When calculated at the optimal diastolic blood pressure threshold determined by a receiver operating characteristic curve, the sensitivity, specificity, and positive predictive value of ambulatory blood pressure monitoring were 71% (95% confidence interval 57% to 84%), 82% (72% to 92%), and 66% (51% to 81%), respectively.
  
  
  CONCLUSIONS
  If the WHO-ISH criteria are accepted as the standard for deciding to treat patients with mild hypertension the predictive value of one ambulatory blood pressure recording over 12 hours is too low to detect with confidence those patients who need treatment when managed according to these criteria.
authors: Service d'Informatique Médicale, Hôpital Broussais, Paris, France.
authors: G
authors: G
authors: Chatellier
authors: C
authors: C
authors: Battaglia
authors: J Y
authors: JY
authors: Pagny
authors: P F
authors: PF
authors: Plouin
authors: J
authors: J
authors: Ménard
mesh_terms: D001795:Blood Pressure Determination / Q000379:methods*; D015924:Blood Pressure Monitors; D003657:Decision Making; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D017410:Practice Guidelines as Topic; D011237:Predictive Value of Tests; D014944:World Health Organization