title: Periodic leg movements in sleep with restless legs syndrome: effect of clonazepam treatment.
abstract: Fifteen patients with restless legs syndrome underwent whole-night polysomnographic recordings before and during clonazepam treatment. The treatment with 0.5 to 1.5 mg clonazepam improved subjective complaints of all the 15 patients. All the patients presented periodic leg movements on the polysomnograms before the treatment. The clonazepam treatment significantly decreased the total numbers of leg movements and the numbers of leg movements per hour without affecting the mean intermovement interval.
authors: Department of Neuropsychiatry, Ehime University School of Medicine, Japan.
authors: J
authors: J
authors: Horiguchi
authors: Y
authors: Y
authors: Inami
authors: A
authors: A
authors: Sasaki
authors: O
authors: O
authors: Nishimatsu
authors: T
authors: T
authors: Sukegawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002998:Clonazepam / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010292:Paresthesia / Q000188:drug therapy; D017286:Polysomnography; D012148:Restless Legs Syndrome / Q000188:drug therapy*; D012894:Sleep Stages / Q000187:drug effects*
chemical_list: D002998:Clonazepam