title: [Pathophysiology of ulcer disease].
abstract: The pathogenesis of ulcer disease is complex. The present outline focuses on four main aspects: 1) The mechanisms governing acid production and the role of acid in ulcer disease. 2) The mechanisms regulating mucosal resistance to injury. 3) The association of ulcer disease with antral gastritis and Helicobacter pylori infection. 4) Ulcer disease and non-steroidal antiinflammatory drugs (NSAIDs). The complex mechanisms underlying maintenance of mucosal integrity in the normal state and in ulcer disease are discussed. Acid/peptic activity as permissive factors are related to impaired mucosal resistance due to Helicobacter infection or NSAID intake.
authors: Abteilung für Gastroenterologie, Departement Innere Medizin, Kantonsspital, Basel.
authors: C
authors: C
authors: Beglinger
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D005744:Gastric Acid / Q000502:physiology; D005753:Gastric Mucosa / Q000503:physiopathology; D016481:Helicobacter Infections / Q000150:complications / Q000503:physiopathology; D016480:Helicobacter pylori; D006801:Humans; D010437:Peptic Ulcer / Q000209:etiology / Q000503:physiopathology*; D012307:Risk Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal
vernacular_title: Pathophysiologie der Ulkuskrankheit.