[Liver function tests in a clinical comparison].
Various liver function tests were evaluated in regard to a quantitative estimation of the impairment of liver function related to the Child-Pugh classification in 32 patients with cirrhosis. Only the ICG-test revealed significant differences between healthy subjects and cirrhotic patients in stadium Child A, B and C. When ICG-dye retention values were plotted as a function of the individual score units of the Child-Pugh classification, a linear relationship with a correlation coefficient of 0.7 was obtained. In contrast to the ICG-test, the MEGX- and galactose elimination capacity (GEC)-test as well as static parameters of liver function (cholinesterase activity, prealbumin concentration, coagulation factor V and VII) resulted in less significant differentiation of the various Child classes. The MEGX-test, GEC, concentration of prealbumin, coagulation factor V and VII were only weakly correlated to the score units of the Child-Pugh index. The results of this study indicate that of all evaluated parameters only the ICG-test is suitable for objective and graduated analysis of liver function in patients with cirrhosis.
Stremmel
W
W
Medizinische Klinik D, Heinrich-Heine-Universität Düsseldorf, Bundesrepublik Deutschland.
Wojdat
R
R
Groteguth
R
R
Zoedler
M
M
Ebener
T
T
Niederau
C
C
Becker
H
H
Strohmeyer
G
G
D002802:Cholinesterases / Q000032:analysis; D005165:Factor V / Q000032:analysis; D005167:Factor VII / Q000032:analysis; D005690:Galactose; D006501:Hepatic Encephalopathy / Q000145:classification / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D007208:Indocyanine Green; D008012:Lidocaine / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D008103:Liver Cirrhosis / Q000145:classification / Q000175:diagnosis* / Q000209:etiology; D008111:Liver Function Tests / Q000145:classification / Q000379:methods*; D008657:Metabolic Clearance Rate / Q000502:physiology; D011228:Prealbumin / Q000032:analysis; D011517:Prothrombin Time; D012016:Reference Values; D012709:Serum Albumin / Q000032:analysis
D011228:Prealbumin; D012709:Serum Albumin; D005165:Factor V; D005167:Factor VII; D008012:Lidocaine; C001173:monoethylglycinexylidide; D002802:Cholinesterases; D007208:Indocyanine Green; D005690:Galactose
Leberfunktionstests im klinischen Vergleich.