Antidepressant effect of carbamazepine--the role of dopaminergic and noradrenergic agents.
Fourteen days of treatment with 20 mg/kg/day carbamazepine (CBZ) reduced the immobility time in the behavioral "despair" test in rats. Two blockers of dopaminergic receptors: haloperidol (0.5 mg/kg) and sulpiride (100 mg/kg) antagonized the reduction of immobility caused by CBZ. The anti-immobility effect of CBZ was also counteracted by clonidine (0.1 mg/kg) an agonist of presynaptic alpha 2 adrenoreceptors and propranolol (5 mg/kg) beta-adrenolytic drug.
Słuzewska
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Department of Pharmacology, Medical Academy, Poznań, Poland.
Chodera
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D000818:Animals; D002220:Carbamazepine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D003000:Clonidine / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013469:Sulpiride / Q000494:pharmacology*; D013550:Swimming
D002220:Carbamazepine; D013469:Sulpiride; D011433:Propranolol; D006220:Haloperidol; D003000:Clonidine