Magnetic fields stimulate peripheral nerve regeneration in hypophysectiomized rats.
The effect of a sinusoidal 50 Hz magnetic field, 0.4 mT on regeneration of the rat sciatic nerve was studied. The sciatic nerve of intact and hypophysectomized rats was crushed and regeneration was evaluated by the pinch test and by immunocytochemical staining for neurofilaments. The animals were exposed to the magnetic field for 3-6 days, between a pair of Helmholtz coils. Hypophysectomy of the rats resulted in an impaired regeneration. However, the magnetic field exposure stimulated regeneration in both the intact and hypophysectomized animals. The results imply that the pituitary gland is not involved in magnetic field induced stimulation of nerve regeneration.
Rusovan
A
A
Department of Animal Physiology, University of Lund, Sweden.
Kanje
M
M
D000818:Animals; D004574:Electromagnetic Fields; D005260:Female; D007016:Hypophysectomy; D007150:Immunohistochemistry; D007382:Intermediate Filaments / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology* / Q000528:radiation effects; D010525:Peripheral Nerves / Q000502:physiology* / Q000528:radiation effects; D010812:Physical Stimulation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000502:physiology / Q000528:radiation effects