title: Elimination of the chloride interference on the determination of arsenic using hydride generation inductively coupled plasma mass spectrometry.
abstract: In the determination of arsenic, attention has recently focused on the speciation of As(III) and As(V). Reversed-phase HPLC can be used to efficiently separate these two arsenic species. When inductively coupled plasma mass spectrometry is used for arsenic detection, an isobaric interference at m/z 75 is caused by the presence of chloride in the sample. These experiments describe the use of hydride generation in conjunction with a polypropylene-membrane gas-liquid separator to completely eliminate the transport of chloride to the plasma. A detection limit of 0.46 ppb for As(III) was achieved with this system. The chromatographic resolution of the system was not compromised by the addition of the gas-liquid separator. A determination of the arsenic content of a NIST urine sample was performed to demonstrate the effectiveness of the chloride elimination.
authors: Department of Chemistry, University of Cincinnati, Ohio 45221-0172.
authors: W C
authors: WC
authors: Story
authors: J A
authors: JA
authors: Caruso
authors: D T
authors: DT
authors: Heitkemper
authors: L
authors: L
authors: Perkins
mesh_terms: D001151:Arsenic / Q000032:analysis*; D002138:Calibration; D002712:Chlorides / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods*
chemical_list: D002712:Chlorides; D001151:Arsenic