Effects of nifedipine on placental blood flow, placental weight and fetal weight in normotensive and spontaneously hypertensive rats.
The effect of nifedipine on placental blood flow was investigated in spontaneously hypertensive rats (SHR) and compared with that in normotensive Wistar Kyoto rats (WKY) by means of the clearance of hydrogen gas generated by electrolysis. The placental blood flow of nifedipine-treated WKY (5, 10 and 25 mg/kg) was significantly (p < 0.05) reduced compared with that of WKY control. On the other hand, the placental blood flow of nifedipine-treated SHR did not change compared with that of SHR control. These data suggest that nifedipine has different effects on placental blood flow in SHR and WKY.
Furuhashi
N
N
Department of Obstetrics and Gynecology, Tohoku University, School of Medicine, Sendai, Japan.
Tsujiei
M
M
Kimura
H
H
Nagae
H
H
Yajima
A
A
D000818:Animals; D005260:Female; D005333:Fetus / Q000187:drug effects*; D009543:Nifedipine / Q000009:adverse effects* / Q000627:therapeutic use; D010920:Placenta / Q000098:blood supply* / Q000187:drug effects; D011225:Pre-Eclampsia / Q000188:drug therapy; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012039:Regional Blood Flow / Q000187:drug effects
D009543:Nifedipine