Short-term in vivo regulation of prolactin receptors in the liver, testes, kidneys, and mammary gland of rats.
Infusion of 17-beta-estradiol for 3 h caused a more than 100% increase in the number of PRL receptors (PRL) in the microsomal liver fraction of male rats without affecting the hormone-receptor affinity. A small but significant increase in PRL receptors also was found in testes but not kidneys. Testosterone infusion to female virgin rats for a similar time period resulted in some nonsignificant decreases in PRL receptors in the liver but not the mammary gland or kidneys. Testosterone infusion to males or 17-beta-estradiol infusion to females did not change the number or affinity of PRL and growth hormone receptors. The level of serum PRL was not influenced during infusion with both hormones.
Barash
I
I
Department of Biochemistry and Human Nutrition, Faculty of Agriculture, Hebrew University of Jerusalem, Rehovot, Israel.
Madar
Z
Z
Gertler
A
A
D000818:Animals; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007457:Iodine Radioisotopes; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D008321:Mammary Glands, Animal / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011981:Receptors, Prolactin / Q000187:drug effects* / Q000378:metabolism; D013737:Testis / Q000187:drug effects; D013739:Testosterone / Q000494:pharmacology*; D013997:Time Factors; D014781:Viscera / Q000187:drug effects* / Q000378:metabolism
D007457:Iodine Radioisotopes; D011981:Receptors, Prolactin; D013739:Testosterone; D004958:Estradiol