Post cardiac arrest hyperoxic resuscitation enhances neuronal vulnerability of the respiratory rhythm generator and some brainstem and spinal cord neuronal pools in the dog.
Selective neuronal vulnerability of the motor cortex, basal ganglia, brainstem, medulla, cerebellum, C6 and L6 segments of the spinal cord were studied after 15 min of cardiac arrest followed by 1 h of normoxic or hyperoxic resuscitation using the suppressive Nauta method in dogs. Hyperoxic resuscitation causes characteristic somatodendritic argyrophilia of the interneuronal pool in the spinal cord and lower medulla. Cuneate, lateral reticular, supraspinal, and caudal trigeminal nuclei as well as the dorsal and ventral respiratory neuronal groups were heavily involved. Similarly, the Purkinje cells, neurons in the middle and deep portions of the mesencephalic tectum, perirubral, pretectal, posterior commissure, middle-sized striatal and giant pyramidal (Betz's) neurons in the motor cortex became argyrophilic. Hyperoxic resuscitation versus normoxic resuscitation causes statistically significant somatodendritic argyrophilia of the dorsal respiratory group, cuneate, dorsal lateral geniculate and thalamic reticular nuclei.
Marsala
J
J
Institute of Neurobiology, Slovak Academy of Sciences, Kosice.
Marsala
M
M
Vanicky
I
I
Galik
J
J
Orendacova
J
J
D000818:Animals; D001933:Brain Stem / Q000166:cytology / Q000502:physiology*; D016887:Cardiopulmonary Resuscitation; D003593:Cytoplasm / Q000378:metabolism; D004285:Dogs; D006323:Heart Arrest / Q000503:physiopathology*; D006651:Histocytochemistry; D009474:Neurons / Q000502:physiology*; D010102:Oxygen Inhalation Therapy; D011689:Purkinje Cells / Q000502:physiology; D015656:Respiratory Mechanics / Q000502:physiology; D013116:Spinal Cord / Q000166:cytology / Q000502:physiology*; D016276:Ventricular Function