Modeling rhodopsin, a member of G-protein coupled receptors, by computer graphics. Interpretation of chemical shifts of fluorinated rhodopsins.
An attempt has been made to construct a 3-D model of rhodopsin, a member of G-protein coupled receptors. Sequence homology of rhodopsin with the latter was a factor considered in the modeling procedure. The constructed model has been used to compare currently available specific protein/substrate interaction information, the shape of the binding cavity derived from shape of binding retinal isomers and analogs and challenged to explain recently available results from a series of fluorinated rhodopsins.
Mirzadegan
T
T
Parke-Davis Pharmaceutical Research Division, Warner-Lambert Co., Ann Arbor, MI 48105.
Humblet
C
C
Ripka
W C
WC
Colmenares
L U
LU
Liu
R S
RS
D000595:Amino Acid Sequence; D000818:Animals; D003196:Computer Graphics; D005461:Fluorine / Q000737:chemistry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010777:Photochemistry; D012243:Rhodopsin / Q000737:chemistry* / Q000235:genetics
D005461:Fluorine; D012243:Rhodopsin