A new anthracycline antibiotic, cinerubin R. Taxonomy, structural elucidation and biological activity.
A novel anthracycline antibiotic, cinerubin R, was isolated from the fermentation broth of Streptomyces eurythermus strain H1715MY2. The structure of cinerubin R was elucidated to be 4"-aculosyl-4'-rhodinosyl-7-rhodosaminyl-epsilon-py rromycinone. Cinerubin R was active against Gram-positive bacteria and inhibited the growth of divergent multi-drug-resistant cells to the same extent as their parental cells.
Nakata
M
M
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Japan.
Saito
M
M
Inouye
Y
Y
Nakamura
S
S
Hayakawa
Y
Y
Seto
H
H
D000818:Animals; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002452:Cell Count; D002470:Cell Survival; D002850:Chromatography, Gel; D004317:Doxorubicin / Q000494:pharmacology; D004351:Drug Resistance; D004354:Drug Screening Assays, Antitumor; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008826:Microbial Sensitivity Tests; D013302:Streptomyces / Q000737:chemistry / Q000145:classification; D014407:Tumor Cells, Cultured
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; C078932:cinerubin R; D004317:Doxorubicin