title: Prediction of advanced puberty by height velocity in children with acute lymphoblastic leukemia.
abstract: Pubertal development was retrospectively evaluated in 58 children with cancer, mostly acute lymphoblastic leukemia (ALL), who are in complete remission and off chemotherapy. Six girls [5 patients with ALL, and 1 with malignant lymphoma (NHL)] showed advanced puberty (25.0%, 6 of 24 female patients with ALL and NHL) through the evaluation of their growth velocity. No evidence for advanced puberty was seen in the males. All 6 girls had received cranial irradiation for central nervous system prophylaxis and systemic chemotherapy including glucocorticoid. The mean age at onset of the pubertal growth spurt in these 6 girls was significantly lower than for girls with a solid tumor [6.90 +/- 0.10 and 9.00 +/- 0.77 (mean +/- SD) years, respectively (p < 0.01)]. By simply evaluating the height velocity, we could predict advanced puberty which was ultimately associated with short stature.
authors: Department of Pediatrics, Mie University School of Medicine, Japan.
authors: H
authors: H
authors: Kawasaki
authors: E
authors: E
authors: Azuma
authors: S
authors: S
authors: Washio
authors: H
authors: H
authors: Taneda
authors: M
authors: M
authors: Kubo
authors: M
authors: M
authors: Ido
authors: M
authors: M
authors: Sakurai
mesh_terms: D000293:Adolescent; D001827:Body Height; D001932:Brain Neoplasms / Q000517:prevention & control; D001940:Breast / Q000033:anatomy & histology; D002648:Child; D004958:Estradiol / Q000097:blood; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008223:Lymphoma / Q000532:radiotherapy; D008297:Male; D008572:Menarche; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000503:physiopathology* / Q000532:radiotherapy; D011629:Puberty, Precocious / Q000175:diagnosis* / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects*; D012189:Retrospective Studies
chemical_list: D004958:Estradiol; D007986:Luteinizing Hormone; D013006:Growth Hormone