[Thiophene as a structural element of physiologically active substances. 20. Thiophene analogs of the leukotriene D4 antagonist Ro 23-3544].
The synthesis of 6-Acetyl-7-[[5-(5-acetyl-4-hydroxy-3-propyl-2-thienyl- oxy)pentyl]oxy]-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid (1), a thiophene analogue of the leukotriene antagonist Ro 23-3544, is described. Compound 1 shows almost no effect on leukotriene D4 induced broncho-constriction on anesthesized guinea pigs.
Binder
D
D
Institut für Organische Chemie, Technischen Universität, Wien.
Koch
A
A
Rovenszky
F
F
Stroissnig
H
H
D000818:Animals; D001578:Benzopyrans / Q000138:chemical synthesis / Q000494:pharmacology*; D016084:Bronchoconstriction / Q000187:drug effects; D006168:Guinea Pigs; D066298:In Vitro Techniques; D013189:SRS-A / Q000037:antagonists & inhibitors*; D013876:Thiophenes / Q000737:chemistry*
D001578:Benzopyrans; D013189:SRS-A; D013876:Thiophenes; C053877:ablukast
Thiophen als Strukturelement physiologisch aktiver Substanzen, 20. Mitt. Ein Thiophenanalogon des Leukotrien D4 Antagonisten Ro 23-3544.