Protection from oxidative damage in mouse liver cells.
Paracetamol toxicity in mouse hepatocytes involved oxidative stress initiated by the formation of NAPQI. This oxidative component of paracetamol injury is associated with the latter stages of the poisoning process. Ebselen, a drug with GSH-peroxidase activity, was effective in ameliorating these oxidative events.
Harman
A W
AW
Department of Pharmacology, University of Western Australia, Nedlands.
Adamson
G M
GM
Shaw
S G
SG
D000082:Acetaminophen / Q000633:toxicity*; D000818:Animals; D001393:Azoles / Q000494:pharmacology*; D016227:Benzoquinones / Q000378:metabolism; D002478:Cells, Cultured; D005978:Glutathione / Q000378:metabolism; D007097:Imines / Q000378:metabolism; D054833:Isoindoles; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D016566:Organoselenium Compounds / Q000494:pharmacology*; D010084:Oxidation-Reduction
D001393:Azoles; D016227:Benzoquinones; D007097:Imines; D054833:Isoindoles; D016566:Organoselenium Compounds; D000082:Acetaminophen; C042986:ebselen; C028473:N-acetyl-4-benzoquinoneimine; D005978:Glutathione