Active and passive immunization for tetrodotoxin in mice.
This study describes the possibility of active and passive immunization for tetrodotoxin (TTX) poisoning. TTX was conjugated to keyhole limpet hemocyanin and this conjugate was used as an immunogen in rabbits and mice. Mice immunized with the conjugate were protected from a lethal dose of TTX. Passive protection experiments demonstrated that immunoglobulin from rabbit antiserum exhibited a dose-related therapeutic activity in mice after challenge with TTX.
Fukiya
S
S
Yamaguchi Prefectural Research Institute of Health, Japan.
Matsumura
K
K
D000818:Animals; D004305:Dose-Response Relationship, Drug; D007110:Immunity, Active; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000276:immunology; D051379:Mice; D012710:Serum Albumin, Bovine / Q000276:immunology; D013779:Tetrodotoxin / Q000276:immunology* / Q000633:toxicity
D007074:Immunoglobulin G; D012710:Serum Albumin, Bovine; D013779:Tetrodotoxin