Extremely well differentiated papillary adenocarcinoma of the lung with prominent cilia formation.
We describe a 54-year-old woman with primary pulmonary adenocarcinoma showing a characteristic papillary architecture and prominent cilia formation. Immunohistochemically, the tumor cells were positive for carcinoembryonic antigen (CEA), epithelial membrane antigen (EMA) and Leu-M1, and negative for lactoferrin and surfactant apoprotein. An ultrastructural study also indicated differentiation toward bronchial surface epithelial cells. To our knowledge, this type of neoplasm has not been reported as peripheral-type adenocarcinoma of the lung.
Nakamura
S
S
Department of Pathology and Clinical Laboratories, Aichi Cancer Center Hospital, Nagoya, Japan.
Koshikawa
T
T
Sato
T
T
Hayashi
K
K
Suchi
T
T
D000231:Adenocarcinoma, Papillary / Q000000981:diagnostic imaging / Q000473:pathology*; D001980:Bronchi / Q000166:cytology / Q000648:ultrastructure; D002454:Cell Differentiation; D002923:Cilia / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D008854:Microscopy, Electron; D008875:Middle Aged; D014057:Tomography, X-Ray Computed