MRI white matter hyperintensity in neuroleptic malignant syndrome (NMS)--a clue to pathogenesis?
The case of a young female patient with neuroleptic malignant syndrome (NMS) and extended MRI white matter hyperintensity in the left parietal and both occipital lobes is reported. MRI lesions resembled findings in hypertensive encephalopathy, they were not readily compatible with CNS vasculitis. Venous sinus thrombosis could be ruled out. Vascular encephalopathy with transient white matter edema and a small residual left parietal lesion is suggested. Neurochemical implications are discussed with particular reference to a possible involvement of excitatory amino acids in NMS pathogenesis.
Becker
T
T
Department Psychiatry University of Würzburg, Federal Republic of Germany.
Kornhuber
J
J
Hofmann
E
E
Weller
M
M
Rupprecht
C
C
Beckmann
H
H
D000328:Adult; D001921:Brain / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009459:Neuroleptic Malignant Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D010672:Phenytoin / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D010672:Phenytoin; D011239:Prednisolone