Renal impairment probably induced by etretinate.
A 83-year-old patient had been treated for pityriasis rubra pilaris with 70 mg etretinate daily. He developed acute renal impairment, with creatinine levels reaching 73 mg/l on day 7. After discontinuation of etretinate, all biological changes were reversible. Although renal impairment is not considered as retinoid side effect, the chronology of renal changes is very suggestive of etretinate responsibility.
Cribier
B
B
Clinique Dermatologique, Hôpitaux Universitaires de Strasbourg, France.
Welsch
M
M
Heid
E
E
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000368:Aged; D000369:Aged, 80 and over; D005050:Etretinate / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010916:Pityriasis Rubra Pilaris / Q000188:drug therapy
D005050:Etretinate