title: Regeneration of respiratory epithelia in the rat after free grafting.
abstract: Following free grafting of septal mucosa from the rat to the rectus abdominis muscle, the mucosal membrane was found to degenerate into a flat squamous epithelium with loss of the majority of differentiated epithelial cells. Both the goblet cells and ciliated cells regenerated from stem cells, which appear in large numbers 2 days after transplantation. Microvilli were found initially on the surfaces of developing ciliated cells and were replaced 21 days post-grafting by cilia. The number of goblet cells during regeneration at first exceeded that of the ciliated cells, but decreased with the passage of time. After 4 months there were more ciliated cells, with the respiratory epithelium now appearing no different than the initially transplanted nasal mucosa.
authors: Department of Otorhinolaryngology, University of Tübingen, Federal Republic of Germany.
authors: F
authors: F
authors: Bootz
authors: G
authors: G
authors: Reuter
mesh_terms: D000009:Abdominal Muscles / Q000601:surgery; D000818:Animals; D002454:Cell Differentiation; D002467:Cell Nucleus / Q000648:ultrastructure; D002470:Cell Survival; D002923:Cilia / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004847:Epithelial Cells; D004848:Epithelium / Q000502:physiology / Q000637:transplantation; D008854:Microscopy, Electron; D008871:Microvilli / Q000648:ultrastructure; D009093:Mucus; D009297:Nasal Mucosa / Q000166:cytology / Q000502:physiology* / Q000637:transplantation*; D009300:Nasal Septum; D009336:Necrosis; D051381:Rats; D011917:Rats, Inbred Lew; D012038:Regeneration; D013234:Stem Cells / Q000502:physiology; D013997:Time Factors