title: In vitro evaluation of acaricidal and fungicidal activity of the house dust mite acaricide, Allerbiocid.
abstract: The acaricidal and fungicidal activities of a new acaricide Allerbiocid, formulated for the control of house dust mites, were investigated. The components of the Allerbiocid formula are: 3% benzyl benzoate (acaricidal and fungicidal), 1% tannic acid (protein denaturant) and 0.5% Tween (surface active agent) in 70% isopropyl alcohol (antiseptic). At application rates of both 150 and 250 ml/m2, the acaricidal activity appeared to work by both ingestion and contact and remained active upon contact with mites for up to 10 weeks. When Sabouraud agar was treated with Allerbiocid at a concentration of 5 ml/20 ml medium, the preparation was also found to have fungicidal and fungistatic activities on various species of fungi commonly found in house dust. Allerbiocid contains tannic acid which is a protein denaturant. Levels of Der p I in dust were found to be reduced by over 90% after treatment with Allerbiocid. The importance of denaturation of mite faecal allergens and allergens associated with dead fungal spores is discussed.
authors: Royal Agricultural College, Cirencester, Gloucestershire, U.K.
authors: B J
authors: BJ
authors: Hart
authors: B
authors: B
authors: Guérin
authors: N
authors: N
authors: Nolard
mesh_terms: D000433:1-Propanol / Q000494:pharmacology*; D019840:2-Propanol; D000485:Allergens / Q000187:drug effects; D000818:Animals; D039741:Antigens, Dermatophagoides; D004338:Drug Combinations; D005659:Fungicides, Industrial / Q000494:pharmacology*; D006794:Household Articles; D007306:Insecticides / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008925:Mites / Q000187:drug effects*; D011136:Polysorbates / Q000494:pharmacology*; D011489:Protein Denaturation / Q000187:drug effects
chemical_list: C078710:Allerbiocid; D000485:Allergens; D039741:Antigens, Dermatophagoides; D004338:Drug Combinations; D005659:Fungicides, Industrial; D007306:Insecticides; D011136:Polysorbates; D000433:1-Propanol; D019840:2-Propanol