Postsplenectomy infections.
Serious postsplenectomy infection is a significant threat to patients. Although the incidence of such infection is low, the resultant mortality is extremely high. This susceptibility to infection and ensuing mortality results from multiple immunologic changes that occur after splenectomy. These changes include alteration in immunoglobulin levels, loss of serum opsonizing proteins, and alterations in antigen clearance and cellular immunity.
Cole
J T
JT
Department of Internal Medicine, Ochsner Clinic, New Orleans, LA 70121.
Flaum
M A
MA
D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D013156:Splenectomy / Q000009:adverse effects*