Hydroxymethylthiobutanoic acid spares methionine from catabolism in the chick.
Two groups of chicks were fed, until they were 3 weeks old, diets supplemented with either DL-methionine (MET) or DL-2-hydroxy-4-methylthiobutanoic acid (HMB). Oxidation to CO2 and uric catabolism of intraperitoneally injected L-[1-14C]MET and DL-[1-14C]HMB were studied comparatively for 8 h. HMB supplementation spares available MET from both oxidative and uric catabolism.
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Laboratoire de Physiologie Métabolique et Nutrition, Université Pierre-et-Marie-Curie, Paris, France.
Pascaud
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D000818:Animals; D002250:Carbon Radioisotopes; D002645:Chickens / Q000378:metabolism*; D004032:Diet; D007700:Kinetics; D008715:Methionine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000493:pharmacokinetics / Q000494:pharmacology; D014527:Uric Acid / Q000378:metabolism
D002250:Carbon Radioisotopes; D014527:Uric Acid; C008391:alpha-hydroxy-gamma-methylmercaptobutyric acid; D008715:Methionine