[Platelet adenylate cyclase activity in alcoholics].
Platelet adenylate cyclase (AC) activity in the long-term abstinent alcoholics, who maintained abstinence from alcohol for at least one year was examined. Guanine nucleotide [Gpp(NH)p] stimulated AC activity was not changed in platelet membrane from long-term abstinent alcoholics. However, the extent of AC activity induced by 250 mM ethanol in vitro, in the presence of 1 microM Gpp(NH)p, was significantly reduced in platelet membrane from long-term abstinent alcoholics. These results suggest that platelet AC activity may be a biological marker for alcoholics.
Saito
T
T
Department of Neuropsychiatry, Sapporo Medical College, Hokkaido, Japan.
Watanabe
M
M
Katamura
Y
Y
Hashimoto
E
E
Nabeshima
A
A
Ashizawa
T
T
Takahata
N
N
D000262:Adenylyl Cyclases / Q000097:blood*; D000437:Alcoholism / Q000201:enzymology*; D015415:Biomarkers / Q000097:blood*; D001792:Blood Platelets / Q000201:enzymology*; D006801:Humans
D015415:Biomarkers; D000262:Adenylyl Cyclases