[The state of lipid peroxidation and of the antioxidant system in the liver and lung microsomes at different periods of sensitization depending on the histamine content].
Histamine impact on lipid peroxidation (LPO) in hepatic and pulmonary microsomes of guinea-pigs sensibilization was studied. It is demonstrated that intensity of chemiluminescence and LPO product content in NADPH-, ascorbat-dependent and spontaneous systems was enhanced in relation to the period of sensibilization process formation and histamine concentration.
Karimov
Kh Ia
KhIa
Komarin
A S
AS
Lysenko
T E
TE
Davletshina
L N
LN
Alimova
A F
AF
D000818:Animals; D000975:Antioxidants; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006632:Histamine / Q000378:metabolism* / Q000494:pharmacology; D007114:Immunization / Q000379:methods; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008163:Luminescent Measurements; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism*; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D013997:Time Factors
D000975:Antioxidants; D006632:Histamine
Sostoianie perekisnogo okisleniia lipidov i antioksidantnoĭ sistemy v mikrosomakh pecheni i legkikh v raznye periody sensibilizatsii v zavisimosti ot soderzhaniia gistamina.