title: Reappearance of vanished bile ducts.
abstract: A 36-year-old Surinam woman with a severe form of toxic epidermal necrolysis of unknown origin is presented. Skin lesions healed gradually without scarring within 3 to 4 weeks, but eye lesions progressed to symblepharon and corneal opacification, resulting in almost complete blindness. In addition, toxic epidermal necrolysis was associated with severe intrahepatic cholestasis caused by vanished bile duct syndrome; viral hepatitis, primary biliary cirrhosis and primary sclerosing cholangitis were excluded. After about six months, intrahepatic chole-stasis improved spontaneously and a third liver biopsy taken after 51 weeks of illness revealed that the bile ducts had reappeared. At present, the patient is relatively well, with no jaundice, although parameters of cholestasis are still elevated: Alkaline phosphatase three times, and gamma GT thirty times the normal values. This sequence of events has to our knowledge never been reported in the literature.
authors: Dept. of Internal Medicine, University of Amsterdam, The Netherlands.
authors: R A
authors: RA
authors: Chamuleau
authors: M J
authors: MJ
authors: Diekman
authors: P J
authors: PJ
authors: Bos
authors: J H
authors: JH
authors: Smitt
authors: A
authors: A
authors: Bosma
authors: P T
authors: PT
authors: Schellekens
mesh_terms: D000328:Adult; D001653:Bile Ducts, Intrahepatic / Q000473:pathology; D002779:Cholestasis / Q000150:complications; D005260:Female; D006505:Hepatitis / Q000150:complications; D006801:Humans; D013262:Stevens-Johnson Syndrome / Q000150:complications* / Q000473:pathology