A bovine hyaline cartilage proteinase inhibitor is active against some serine proteinases and inhibits the IL-1 alpha-mediated matrix degradation of bovine articular cartilage explants.
Arsenis
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Research Department, CIBA-GEIGY, Summit, NJ 07901.
D000818:Animals; D002356:Cartilage / Q000737:chemistry*; D002358:Cartilage, Articular / Q000378:metabolism*; D002417:Cattle; D005109:Extracellular Matrix / Q000378:metabolism*; D007375:Interleukin-1 / Q000037:antagonists & inhibitors*; D009924:Organ Culture Techniques; D015842:Serine Proteinase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D013379:Substrate Specificity
D007375:Interleukin-1; D015842:Serine Proteinase Inhibitors