title: Mapping of X chromosome translocation breakpoints in females with Duchenne muscular dystrophy with respect to exons of the dystrophin gene.
abstract: There are rare female patients who suffer from Duchenne or Becker muscular dystrophy because they carry an X;autosome translocation with a breakpoint in the dystrophin gene. We have defined the positions of seven of these breakpoints with respect to exon-containing HindIII fragments detected by dystrophin cDNA. One breakpoint lies between exon-containing HindIII fragments 7 and 8, five breakpoints between exon-containing HindIII fragments 31 to 41, and one lies close to exon-containing-HindIII fragment 50. The distribution of these and of a further seven translocation breakpoints whose positions are known is compared with that reported for deletions and duplications in affected males.
authors: Department of Biochemistry, University of Oxford, UK.
authors: D J
authors: DJ
authors: Cockburn
authors: E A
authors: EA
authors: Munro
authors: I W
authors: IW
authors: Craig
authors: Y
authors: Y
authors: Boyd
mesh_terms: D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D006224:Cricetinae; D003412:Cricetulus; D016189:Dystrophin / Q000235:genetics*; D005091:Exons; D005260:Female; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D009136:Muscular Dystrophies / Q000235:genetics*; D014178:Translocation, Genetic; D014960:X Chromosome
chemical_list: D016189:Dystrophin