[Thiochrome inhibition of alcohol dehydrogenase].
It is shown that thiochrome inhibits alcohol dehydrogenase. Thiochrome is able to be bound with alcohol dehydrogenase more quickly than other thiamine metabolites. This process is specific and has common features with the process of NAD binding by this enzyme. The inhibition of alcohol dehydrogenase by thiochrome is concurrent to NAD. The constant of alcohol dehydrogenase inhibition by thiochrome is 3.9 x 10(-5) M.
Petrov
S A
SA
D000426:Alcohol Dehydrogenase / Q000032:analysis / Q000037:antagonists & inhibitors* / Q000187:drug effects / Q000378:metabolism; D002850:Chromatography, Gel; D004305:Dose-Response Relationship, Drug; D005470:Fluorometry; D009243:NAD / Q000494:pharmacology; D013831:Thiamine / Q000031:analogs & derivatives* / Q000032:analysis / Q000378:metabolism / Q000494:pharmacology; D015003:Yeasts / Q000201:enzymology
D009243:NAD; C005793:thiochrome; D000426:Alcohol Dehydrogenase; D013831:Thiamine
Ingibirovanie alkogol'degidrogenazy tiokhromom.