[Reperfusion injury of myocardial biomembranes after acute fatal hemorrhage and their correction with carnosine].
Studies on inbred male rats revealed that ischemia associated with clinical death caused by haemorrhage with subsequent recirculation and reoxygenation during resuscitation led to an increase in enzyme activities in blood serum and perfusate passed through the coronary bed of isolated hearts, presumably due to impaired membrane integrity. Damage to cardiomyocyte membranes was caused by intensification of LPO concomitant with enhanced glycolysis and lactate accumulation in the cardiac muscle. Carnosine (25 mg/kg) injected simultaneously with recirculation and reoxygenation prevented membrane damage and created optimal conditions for the functioning of membrane enzymes.
Rusakov
V V
VV
Dolgikh
V T
VT
D000818:Animals; D002336:Carnosine / Q000494:pharmacology* / Q000627:therapeutic use; D002462:Cell Membrane / Q000378:metabolism; D004798:Enzymes / Q000378:metabolism; D006019:Glycolysis; D006321:Heart / Q000187:drug effects*; D006470:Hemorrhage / Q000188:drug therapy*; D007773:Lactates / Q000378:metabolism; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy*; D009206:Myocardium / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D051381:Rats
D004798:Enzymes; D007773:Lactates; D002336:Carnosine; D010100:Oxygen
Reperfuzionnye povrezhdeniia biomembran miokarda posle ostroĭ smertel'noĭ krovopoteri i ikh korrektsiia karnozinom.