Experimental acute intoxication with ripe fruit of Karwinskia humboldtiana (Tullidora) in rat, guinea-pig, hamster and dog.
Previous acute toxicity studies with 'Tullidora' in mice showed mainly hepatic and pulmonary complications. We tested samples in rat, guinea-pig, hamster and dog, searching for the mechanism of death. A single oral preparation of ripe fruit of Karwinskia humboldtiana was given to all animals. Clinical signs and histopathology were reproduced in all species except dogs. We propose a selective toxicity of the toxins of this fruit to the lungs and liver.
Bermúdez
M V
MV
Facultad de Medicina, Universidad Autónoma de Nuevo León, Col del Valle, México.
Martinez
F J
FJ
Salazar
M E
ME
Waksman
N
N
Piñeyro
A
A
D000818:Animals; D006224:Cricetinae; D004285:Dogs; D006168:Guinea Pigs; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D010939:Plant Poisoning / Q000473:pathology*; D010947:Plants, Toxic / Q000737:chemistry*; D051381:Rats; D013045:Species Specificity