title: [Synthesis and antimicrobial properties of 3-O-alkyl and 3-O-haloalkyl-D-glucoses].
abstract: A series of 3-O-alkyl and 3-O-haloalkyl-D-glucoses were prepared from 1,2:5,6-di-O-isopropylidene-alpha-D-glucofuranose and their antibacterial activities were evaluated. The compounds with C12 and C14-alkyl chains were the most effective in vitro antibacterial screening, among 3-O-alkyl and 3-O-haloalkyl derivatives. The 3-O-alkyl derivatives were more effective than 3-O-haloalkyl derivatives.
authors: Department of Pharmacy, Kitasato University Hospital, Sagamihara-shi, Japan.
authors: K
authors: K
authors: Yago
authors: K
authors: K
authors: Kawada
authors: T
authors: T
authors: Uchibori
authors: S
authors: S
authors: Zen
authors: F
authors: F
authors: Tomonaga
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D004352:Drug Resistance, Microbial; D004987:Ethers / Q000138:chemical synthesis* / Q000494:pharmacology; D005947:Glucose / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D004987:Ethers; D005947:Glucose