Humoral immune response to the antigen administered as an immune complex.
Antigen (HSA) bound in immune complexes at equivalence with syngeneic anti-HSA antibodies elicit much stronger humoral immune response then soluble HSA. On the other hand, administration of immune complexes formed with xenogeneic (rabbit) anti-HSA antibodies suppressed humoral immune response against HSA, but not against rabbit IgG in mice. We suggest that immunization with antigen bound in immune complex might represent a powerful tool in enhancing humoral immune responses.
Marusić
M
M
Medical Center Paprikovac, Banja Luka, Bosnia.
Marusić-Galesić
S
S
Pokrić
B
B
D000818:Animals; D000910:Antibodies, Heterophile / Q000276:immunology; D000917:Antibody Formation / Q000276:immunology*; D000936:Antigen-Antibody Complex / Q000008:administration & dosage* / Q000276:immunology; D005260:Female; D007114:Immunization; D007074:Immunoglobulin G / Q000276:immunology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009391:Nephelometry and Turbidimetry; D011817:Rabbits; D012709:Serum Albumin / Q000276:immunology
D000910:Antibodies, Heterophile; D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D012709:Serum Albumin