IgG subclasses distribution in immunoglobulin preparations for intravenous use.
The levels of IgG subclasses were determined, by radial immunodiffusion using monoclonal antibodies, in 16 production batches of two human immunoglobulin preparations for intravenous use--Immunovenin and Immunovenin-intact. While the partially degraded preparation--Immunovenin contained exclusively IgG1, the subclass distribution in Immunovenin-intact was close to that observed in normal human serum.
Bozadjiev
L G
LG
Institute of Infectious and Parasitic Diseases, Sofia, Bulgaria.
Bineva
I L
IL
Vassilev
T L
TL
D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D006801:Humans; D005779:Immunodiffusion; D007074:Immunoglobulin G / Q000032:analysis* / Q000145:classification; D016756:Immunoglobulins, Intravenous / Q000737:chemistry* / Q000302:isolation & purification; D011092:Polyethylene Glycols
D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous; D011092:Polyethylene Glycols