title: [Estimation of pulmonary vascular permeability by indocyanine green in permeability pulmonary edema].
abstract: In this study we attempted to estimate pulmonary vascular permeability by indocyanine green (ICG). Permeability pulmonary edema was produced in 9 adult dogs by injecting 0.08 ml/kg oleic acid. We injected 50 mg ICG intravenously in 18 dogs (9 dogs with pulmonary edema and 9 control dogs). We measured the time course of ICG concentrations in pulmonary arterial blood, ICG concentration of peripheral lung tissue, tissue/serum ICG concentration ratios, and wet/dry lung weight ratios. The following results were obtained. The time course of ICG concentration in pulmonary arterial blood showed peak values at 2 minutes and became constant at 5 or 10 minutes after injection. The ICG concentration in peripheral lung tissue, tissue/serum ICG concentration ratios, and wet/dry lung weight ratios in the pulmonary edema group were significantly higher than those in the normal group. There was a strong linear correlation between wet/dry lung weight ratio and ICG concentration in peripheral lung tissue, with correlation coefficients of r = 0.936 (p < 0.01) in the right lung and r = 0.901 (p < 0.01) in the left lung. From these results, we conclude that estimation of pulmonary vascular permeability by ICG is a useful method.
authors: First Department of Internal Medicine, Dokkyo University School of Medicine, Tochigi, Japan.
authors: S
authors: S
authors: Kato
authors: T
authors: T
authors: Asai
authors: K
authors: K
authors: Ono
authors: N
authors: N
authors: Onuma
authors: T
authors: T
authors: Nakamoto
authors: M
authors: M
authors: Iizuka
mesh_terms: D000818:Animals; D002199:Capillary Permeability; D004285:Dogs; D007208:Indocyanine Green; D011651:Pulmonary Artery / Q000503:physiopathology*; D011652:Pulmonary Circulation; D011654:Pulmonary Edema / Q000175:diagnosis* / Q000503:physiopathology
chemical_list: D007208:Indocyanine Green