title: Regulation and dysregulation of the hypothalamic-pituitary-adrenal axis. The corticotropin-releasing hormone perspective.
abstract: This article is an up-to-date review of the impact that the discovery of corticotropin-releasing hormone (CRH) has had on basic science and clinical medicine. It discusses hypothalamic CRH, placental CRH, immune CRH, and hypothalamic and immune CRH. Clinical studies in normal and disease states and synthesis and future directions also are presented.
authors: Section on Pediatric Endocrinology, National Institute of Child Health and Human Development, Bethesda, Maryland.
authors: G P
authors: GP
authors: Chrousos
mesh_terms: D000308:Adrenocortical Hyperfunction / Q000175:diagnosis / Q000378:metabolism; D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000502:physiology*; D003480:Cushing Syndrome / Q000175:diagnosis / Q000378:metabolism; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D008297:Male; D010913:Pituitary-Adrenal System / Q000502:physiology*; D051381:Rats; D011917:Rats, Inbred Lew; D013312:Stress, Physiological / Q000503:physiopathology
chemical_list: D003346:Corticotropin-Releasing Hormone