Effects of 2-mercaptopropionylglycine on the development of X-ray-induced cataract in rats.
The effect of 2-mercaptopropionylglycine on the development of cataract induced by a single dose of X-ray (10 Gy) was investigated in rats. Intraperitoneal injection of 20 mg/kg, three times weekly starting 1 day after irradiation delayed the development of X-ray-induced cataracts significantly. The amounts of non-protein SH groups, malondialdehyde and the Na+/K+ ratio, in the lenses of rats post-treated with the drug were significantly maintained at normal levels even at 27 weeks after irradiation. On the other hand, a single administration of 250 mg/kg of the compound, 30 min prior to irradiation had no effect on cataract progression induced by X-ray.
Kobayashi
S
S
Kyoritsu College of Pharmacy, Tokyo, Japan.
Kasuya
M
M
Ishii
Y
Y
Takehana
M
M
Sakai
K
K
Suzuki
N
N
Itoi
M
M
D000818:Animals; D002386:Cataract / Q000378:metabolism / Q000517:prevention & control*; D005260:Female; D007274:Injections, Intraperitoneal; D007908:Lens, Crystalline / Q000378:metabolism / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D008625:Tiopronin / Q000008:administration & dosage / Q000494:pharmacology*
D011837:Radiation-Protective Agents; D008625:Tiopronin