Distribution of intraperitoneally injected microspheres labeled with the alpha-emitter astatine (211At) compared with phosphorus (32P) and yttrium (90Y) colloids in mice.
The alpha-emitter 211At was bound to polymer microspheres with a diameter of 1.8 microns. The distributions in mice of intraperitoneally injected 211At microspheres, 90Y silicate colloid, and 32P chromic phosphate colloid were compared. The microspheres with 211At spread rapidly in the peritoneal cavity and remained mainly on the intraperitoneal surfaces. Intraperitoneal injection of 90Y colloid resulted in high levels in intraperitoneal fat and the diaphragm, but 1 day after injection 8.5% of the injected dose per gram was found in blood and after 6 days 2.5% was observed in bone. The highest accumulation of 32P was found in liver and spleen. The injection of additional nonradioactive chromic phosphate colloid resulted in an even higher accumulation of 32P in spleen and liver. The same phenomenon was not observed with 211At microspheres. It is suggested that it is not only the particle size which is important in the distribution of intraperitoneally injected colloid, but the amount of colloid, the type of colloid, the addition or presence of other substances such as ascites, and the animal species might also influence the distribution. In conclusion, the intraperitoneal distribution of 211At-labeled microspheres in mice was favorable compared with 90Y and 32P colloid. These data must be viewed cautiously since the distribution might be different in other animal species or humans.
Vergote
I
I
Department of Gynecologic Oncology, Norwegian Radium Hospital, Oslo.
Larsen
R H
RH
De Vos
L
L
Winderen
M
M
Ellingsen
T
T
Bjørgum
J
J
Hoff
P
P
Aas
M
M
Tropé
C
C
Nustad
K
K
D000818:Animals; D001246:Astatine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003102:Colloids; D005260:Female; D007274:Injections, Intraperitoneal; D007553:Isotope Labeling; D051379:Mice; D008807:Mice, Inbred BALB C; D008863:Microspheres; D010761:Phosphorus Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D015021:Yttrium Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics*
D003102:Colloids; D010761:Phosphorus Radioisotopes; D015021:Yttrium Radioisotopes; D001246:Astatine