Mating-type gene switching in Saccharomyces cerevisiae.
The study of yeast mating-type (MAT) gene switching has provided insights into several aspects of the regulation of gene expression. MAT switching is accomplished by a highly programmed site-specific homologous recombination event in which mating-type-specific sequences at MAT are replaced by alternative DNA sequences copied from one of two unexpressed donors. The mating-type system has also provided an opportunity to study both the genetic regulation of gene silencing by alterations in chromatin structure, and the basis of preferential recombination between a recipient of genetic information and one of several possible donors.
Haber
J E
JE
Rosenstiel Center, Brandeis University, Waltham, MA 02254.
D000483:Alleles; D005656:Fungal Proteins / Q000235:genetics*; D005785:Gene Conversion; D015966:Gene Expression Regulation, Fungal; D015321:Gene Rearrangement; D005800:Genes, Fungal; D000072235:Mating Factor; D008938:Mitosis; D008957:Models, Genetic; D010455:Peptides / Q000235:genetics*; D010675:Pheromones / Q000235:genetics*; D011995:Recombination, Genetic; D012098:Reproduction / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000502:physiology
D005656:Fungal Proteins; D010455:Peptides; D010675:Pheromones; D000072235:Mating Factor