Urinary and amniotic epidermal growth factor during normal and abnormal pregnancies. A comparison based upon umbilical Doppler velocimetry.
Fetal growth retardation is associated with abnormal umbilical flow velocity. We have begun a systematic study of growth factors and their relationship to this specific pattern of growth retardation. Using a specific double-antibody epidermal growth factor (EGF) 125I-radioimmunoassay, we studied urinary EGF in normal pregnancy from 5 to 42 weeks of gestation, and amniotic fluid EGF from 18 to 24 weeks. EGF levels increased from early pregnancy until 21-28 weeks, when they declined to a level at term similar to non-pregnant controls and first-trimester pregnancy levels. There was no significant difference in urinary EGF levels between women delivering appropriate-for-gestational-age (AGA) infants, and those delivering small-for-gestational-age infants (SGA). We conclude that the urinary EGF is not different in the SGA pregnancy from normal pregnancy.
Moharam
A
A
Department of Obstetrics and Gynecology, Brookdale Hospital, Brooklyn, New York.
Aleem
F
F
Farmakides
G
G
Schulman
H
H
Maghzangy
M
M
Rashed
A
A
Konstantinou
E
E
D000653:Amniotic Fluid / Q000378:metabolism*; D003404:Creatinine / Q000378:metabolism; D004815:Epidermal Growth Factor / Q000378:metabolism* / Q000652:urine*; D005260:Female; D005317:Fetal Growth Retardation / Q000378:metabolism* / Q000652:urine; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D010920:Placenta / Q000098:blood supply; D011247:Pregnancy; D014463:Ultrasonography; D014469:Umbilical Arteries / Q000000981:diagnostic imaging*
D004815:Epidermal Growth Factor; D003404:Creatinine