Effects of furosemide and pentoxifylline on blood flow properties in horses.
The effects of furosemide and pentoxifylline on blood flow properties in horses were investigated. Hematologic and rheologic changes were examined in 4 horses before and 3 minutes after administration of epinephrine (1 mg, IV). The next day, hemorheologic changes were determined before and 3 hours after administration of furosemide (1 mg/kg of body weight, IM), and after administration of epinephrine at the sampling at 3 hours. Hematologic and rheologic changes were evaluated weekly in 3 horses given pentoxifylline (8.5 mg/kg, q 12 h, PO) for 28 days. In addition, hemorheologic responses to epinephrine were determined on days 0, 14, and 28 of pentoxifylline treatment. Neutrophil filtration studies were also performed 2 hours after IV administration of pentoxifylline (8.5 mg/kg). Postepinephrine values for PCV, RBC and WBC counts, and blood viscosity were greater than preepinephrine values. Erythrocyte sedimentation rates decreased after epinephrine, whereas RBC filterability did not change. Treatment with furosemide was associated with increases in mean RBC hemoglobin concentration and blood viscosity. Filterability of RBC did not change. Treatment with pentoxifyllie resulted in an increase in RBC filterability and erythrocyte sedimentation rate and a decrease in PCV; however, mean values for hematocrit and RBC count did not change. Treatment with pentoxifylline did not result in a change in resting blood viscosity, but markedly reduced the postepinephrine increase in blood viscosity. Neither IV nor orally administered pentoxifylline had an effect on neutrophil filtration. It was concluded that pentoxifylline has beneficial effects on RBC filterability and postepinephrine changes in blood viscosity, which may contribute to improvements of microcirculatory blood flow. In addition, furosemide may exacerbate exercise-associated hyperviscosity in horses.
Geor
R J
RJ
Department of Clinical and Population Sciences, College of Veterinary Medicine, University of Minnesota, St Paul 55108.
Weiss
D J
DJ
Burris
S M
SM
Smith
C M
CM
D000818:Animals; D001772:Blood Cell Count / Q000187:drug effects; D001775:Blood Circulation / Q000187:drug effects* / Q000502:physiology; D001809:Blood Viscosity / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D005665:Furosemide / Q000494:pharmacology*; D006736:Horses / Q000097:blood / Q000502:physiology*; D008297:Male; D010431:Pentoxifylline / Q000494:pharmacology*
D005665:Furosemide; D010431:Pentoxifylline; D004837:Epinephrine