[Studies on the synthesis of dimethyl 4-hydroxy-4'-methoxy-5,6,5',6'-bismethylenedioxy biphenyl-2,2'-dicarboxylate--an essential metabolite of biphenyl diester].
This paper reports the synthesis of dimethyl 4-hydroxy-4'-methoxy-5,6,5',6'-bismethylenedioxybiphenyl-2,2'-dica rboxylate (II). Various conditions for bromination were tried to find the best one for synthesis of the key intermediate compound 6. After Ullmann condensation of 6 with 8 and hydrogenolysis, the title compound II was obtained. It was proved to be identical with the isolated metabolite of biphenyl diester by spectral data.
Zhan
S L
SL
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
Zhang
C Z
CZ
D001713:Biphenyl Compounds / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004149:Dioxoles / Q000138:chemical synthesis*
D001713:Biphenyl Compounds; D004149:Dioxoles; C043146:7-hydroxy-7'-methoxy-4,4'-bis(1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester