Duration of the protective effect of polyaspartic acid on experimental gentamicin nephrotoxicity.
It is known that daily polyaspartic acid (PAA) protects the kidney from gentamicin nephrotoxicity in a standardized rat model despite marked cortical accumulation of the aminoglycoside. The present experiments address the duration of PAA protection. When administered every other day, PAA provided functional and histologic protection against gentamicin-induced toxicity. A stepwise reduction in nephroprotection occurred as the dosage interval was prolonged.
Swan
S K
SK
Division of Nephrology, Oregon Health Sciences University, Portland 97201.
Gilbert
D N
DN
Kohlhepp
S J
SJ
Leggett
J E
JE
Kohnen
P W
PW
Bennett
W M
WM
D000818:Animals; D003404:Creatinine / Q000097:blood; D004334:Drug Administration Schedule; D005839:Gentamicins / Q000633:toxicity*; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D009399:Nephrons / Q000187:drug effects*; D010455:Peptides / Q000493:pharmacokinetics / Q000627:therapeutic use*; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors
D005839:Gentamicins; D010455:Peptides; C017645:polyaspartate; D003404:Creatinine