title: Effects of Skeletonema costatum extracts on the central nervous system.
abstract: We report the effects of aqueous extracts of the microalga Skeletonema costatum Greve (Cleve) (Bacillariophyceae) on spontaneous motor activity, rectal temperature, motor coordination, amphetamine-induced hypermotility, exploratory behaviour, muscle relaxation, catalepsy, conditioned avoidance responses, oxotremorin-induced cholinergic syndrome, and pentylenetetrazole-induced convulsions. The S. costatum extract at dosages of 310 and 620 mg/kg works like an antidopaminergic drug with anticholinergic properties, that does not induce catalepsy and with a notable muscle relaxing activity.
authors: Departamento de Farmacología, Facultad de Farmacia, Universidad de Santiago de Compostela, Galicia, Spain.
authors: R
authors: R
authors: Villar
authors: M R
authors: MR
authors: Laguna
authors: J M
authors: JM
authors: Calleja
authors: I
authors: I
authors: Cadavid
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D017377:Diatoms / Q000737:chemistry*; D005260:Female; D008297:Male; D051379:Mice