title: Functionalized, probe-containing, latex nanospheres.
abstract: Synthesis of surface-functionalized, probe-containing latex nanospheres is described. Approximately 40,000 probe ions may be encapsulated in a nanosphere of 50 nm diameter. The probe may be a radionuclide or a lanthanide with long-lived fluorescence. Alternatively, a "cargo" of pharmaceutical interest may be used. The surface of each nanosphere contains thousands of acid groups which may be functionalized for subsequent attachment to biomolecules such as antibodies. Functionalized nanospheres have been successfully coupled to a tobacco virus.
authors: Department of Chemistry, University of Missouri-Columbia 65211.
authors: C Y
authors: CY
authors: Guo
authors: R R
authors: RR
authors: Shankar
authors: S
authors: S
authors: Abe
authors: Z
authors: Z
authors: Ye
authors: R N
authors: RN
authors: Thomas
authors: J E
authors: JE
authors: Kuo
mesh_terms: D001710:Biotin; D004058:Diffusion; D004337:Drug Carriers; D007202:Indicators and Reagents; D007840:Latex; D008854:Microscopy, Electron / Q000379:methods; D008855:Microscopy, Electron, Scanning / Q000379:methods; D008863:Microspheres; D010942:Plant Viruses / Q000648:ultrastructure*; D010947:Plants, Toxic; D013050:Spectrometry, Fluorescence / Q000295:instrumentation / Q000379:methods; D013725:Terbium / Q000032:analysis; D014026:Nicotiana
chemical_list: D004337:Drug Carriers; D007202:Indicators and Reagents; D007840:Latex; D013725:Terbium; D001710:Biotin