Naturally occurring intestinal epithelial neoplasms in aged Crl:CD BR rats.
Spontaneous primary epithelial neoplasms of the intestinal tract occurred in 6/682 (0.9%) male and 1/694 (0.1%) female Sprague-Dawley rats. Six of 7 neoplasms were adenocarcinomas, and 1 of 7 was an adenoma. Metastasis to the liver or lung occurred in 3 of the rats with adenocarcinoma. These findings are consistent with those reported for female Sprague-Dawley rats and for males and females of other strains over the past 25 years. The intestinal neoplasm incidence in males exceeded that reported for other Sprague-Dawley males with one exception, reported 30 years ago.
Zwicker
G M
GM
Toxicology Department, Marion Merrell Dow, Inc., Indianapolis, Indiana 46268.
Eyster
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RC
Sells
D M
DM
Gass
J H
JH
D000230:Adenocarcinoma / Q000473:pathology*; D000236:Adenoma / Q000473:pathology*; D000818:Animals; D005260:Female; D007413:Intestinal Mucosa / Q000473:pathology; D007414:Intestinal Neoplasms / Q000473:pathology*; D008297:Male; D009362:Neoplasm Metastasis; D051381:Rats; D011919:Rats, Inbred Strains; D017207:Rats, Sprague-Dawley