Factors in children that predict performance on the intracarotid amobarbital procedure.
The intracarotid amobarbital procedure (IAP) is frequently used to determine hemispheric language dominance and memory competence in individuals with intractable epilepsy before surgical intervention. The present study focused on outcome results concerning use of this technique in children. The IAP was an effective tool in determining their hemispheric language dominance. Seven characteristics, including age, gender, dose level of sodium amobarbital, Full-Scale I.Q., hemispheric side of injection (left or right), language dominance of hemisphere injected, and order of injection (first or second) were examined as possible factors predictive of memory performance on the IAP. Results suggest that after injection of the hemisphere suspected of containing the primary seizure origin, children aged < 13 years who had the left language-dominant hemisphere injected were significantly less likely to pass IAP memory tasks than were older children or younger children who had the nondominant hemisphere injected. These findings suggest that the IAP is a reliable indicator of hemispheric memory competence in children aged > 13 years or younger children whose suspected seizure focus is located in the nondominant language hemisphere.
Williams
J
J
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles.
Rausch
R
R
D000293:Adolescent; D000367:Age Factors; D000654:Amobarbital / Q000008:administration & dosage; D002343:Carotid Artery, Internal; D002404:Catheterization; D002540:Cerebral Cortex / Q000503:physiopathology / Q000601:surgery; D002648:Child; D004292:Dominance, Cerebral / Q000187:drug effects / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D004827:Epilepsy / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006801:Humans; D007361:Intelligence Tests; D007802:Language; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D009483:Neuropsychological Tests; D013060:Speech / Q000187:drug effects / Q000502:physiology
D000654:Amobarbital