Cimetidine-dobutamine interaction?
The report describes a patient during induction of anaesthesia for coronary artery by-pass grafting, in whom the infusion of dobutamine at a rate of 5 micrograms.kg-1.min-1 resulted in unanticipated severe hypertension. The exaggerated response may be attributed to cimetidine--dobutamine interaction.
Baraka
A
A
Department of Anesthesiology, American University of Beirut, Lebanon.
Nauphal
M
M
Arab
W
W
D000771:Anesthesia, Intravenous; D002927:Cimetidine / Q000009:adverse effects*; D001026:Coronary Artery Bypass; D004280:Dobutamine / Q000009:adverse effects*; D004347:Drug Interactions; D006801:Humans; D006973:Hypertension / Q000139:chemically induced*; D007431:Intraoperative Complications / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged
D004280:Dobutamine; D002927:Cimetidine