[Long-term local tolerability to intranasally administered salmon calcitonin in post-menopausal osteoporosis].
The aim of this study was to acquire further knowledge relative to the local tolerability of synthetic salmon Calcitonin, administered by the intranasal route. The Authors have evaluated several olfactometry parameters in a group of patients treated for twelve months with the drug. The Wright matrix test and the olfacto-respiratory reflex test were performed. An evaluation regarding mucociliary transport time was additionally effected. No interference on the part of the drug was reported regarding the functional parameters of the nasal mucosa. The excellent local tolerability of intranasal salmon Calcitonin, as already indicated by other Authors, was confirmed, even in terms of specific parameters relative to the olfactory functions.
Gariboldi
L M
LM
Istituto Policattedra di Clinica Otorinolaringoiatrica, Università degli Studi di Parma.
Bolla
I
I
Baroni
M C
MC
Delsignore
R
R
Passeri
M
M
Barberis
F
F
D000281:Administration, Intranasal; D002116:Calcitonin / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D009831:Olfactory Mucosa / Q000187:drug effects; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy*; D012018:Reflex / Q000187:drug effects; D012903:Smell / Q000187:drug effects; D013997:Time Factors
C028815:salmon calcitonin; D002116:Calcitonin
Tollerabilità locale cronica della Calcitonina di salmone somministrata per via endonasale nell'osteoporosi postmenopausale.