title: Monozygotic twins concordant for late-onset probable Alzheimer disease with suspected Alzheimer disease in four sibs.
abstract: Probable Alzheimer disease (AD) is described in 79-year-old male twins with monozygosity confirmed by DNA examination. The first twin to be affected began to show signs of intellectual deterioration at age 70. In the other, onset was at age 72. Four of their living sibs (current age range = 75-92) are also suspected to have AD. The possible roles of genetic and environmental factors in the development of AD in this sibship are discussed.
authors: Geriatric Psychiatry Service, Queen Elizabeth Hospital, Toronto, Ontario, Canada.
authors: H
authors: H
authors: Karlinsky
authors: J M
authors: JM
authors: Berg
authors: A
authors: A
authors: Lennox
authors: P N
authors: PN
authors: Ray
authors: P
authors: P
authors: St George-Hyslop
authors: L A
authors: LA
authors: Farrer
authors: M E
authors: ME
authors: Percy
authors: D F
authors: DF
authors: Andrews
authors: E A
authors: EA
authors: Atack
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000235:genetics*; D001921:Brain / Q000000981:diagnostic imaging; D016172:DNA Fingerprinting; D004200:Diseases in Twins / Q000235:genetics*; D006801:Humans; D008297:Male; D010375:Pedigree; D014057:Tomography, X-Ray Computed; D014430:Twins, Monozygotic