[Preclinical evaluation of the therapeutic efficacy of L-dopa in chronic gastric ulcer].
The authors studied the peculiarities of the course taken by experimental gastric ulcer in rabbits under the effect of the norepinephrine precursor 1-dioxyphenylalanine (L-DOPA) injected parenterally in a dose of 10 mg/kg twice a day for 14 days. As compared to the controls (nontreated ulcer), L-DOPA restored significantly more rapidly the bioenergetic processes in the gastric mucosa which were disturbed as the result of ulcerogenesis, provided for stimulation of reparative regeneration, and reduced the terms of ulcer cicatrization.
Baranovskiĭ
A Iu
AIu
Smolianinov
A B
AB
Zavodskaia
I S
IS
Nilova
T N
TN
D000818:Animals; D002908:Chronic Disease; D004341:Drug Evaluation; D007980:Levodopa / Q000627:therapeutic use*; D008297:Male; D011817:Rabbits; D013276:Stomach Ulcer / Q000188:drug therapy*
D007980:Levodopa
Predklinicheskaia otsenka lechebnoĭ éffektivnosti l-dofa pri khronicheskoĭ iazve zheludka.