title: Potential neurotoxin formation in thermally degraded synthetic ester turbine lubricants.
abstract: Under extreme conditions of thermal degradation, a potent neurotoxin, trimethylolpropane phosphate (TMPP), may be formed by reaction of tricresyl phosphate (TCP, an anti-wear additive) and trimethylolpropane esters (TMPE) of carboxylic acids that may be contained in turbine engine lubricant formulations. The neurotoxin is only formed at extreme temperatures (350-700 degrees C), which has minimized concern for use of the synthetic lubricants under intended applications; however, since researchers are often not privy to the proprietary composition of such lubricants, extreme caution should be exercised in studies of or applications of synthetic lubricants degraded under extreme conditions.
authors: P W
authors: PW
authors: Centers
mesh_terms: D000818:Animals; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry* / Q000633:toxicity; D004952:Esters / Q000737:chemistry* / Q000633:toxicity; D008153:Lubrication; D051379:Mice; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology*; D011409:Propylene Glycols / Q000737:chemistry* / Q000633:toxicity; D014317:Tritolyl Phosphates / Q000737:chemistry* / Q000633:toxicity
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D004952:Esters; D011409:Propylene Glycols; D014317:Tritolyl Phosphates; C065518:4-ethyl-1-phospha-2,6,7 trioxabicyclo(2.2.2)octane-1-oxide