Developmental aspects of neurobehavioural toxicity.
Previous work on the developmental aspects of neurobehavioural toxicity in rats and mice has shown the reliability of a variety of procedures aimed at assessing changes that may have widespread functional consequences, for example: (i) modified Fox batteries to study the maturation of various reflexes and responses after birth, (ii) activity/habituation and analgesia tests with age-specific profiles of reactivity to selected drug challenges, and (iii) simple learning tasks such as active and passive avoidance [1]. We will now summarize more recent work on other portions of the behavioural repertoire which deserve to be thoroughly assessed in "higher-tier" studies.
Bignami
G
G
Laboratory of Pathophysiology, Istituto Superiore di Sanità, Roma, Italy.
Laviola
G
G
Alleva
E
E
Cagiano
R
R
Lacomba
C
C
Cuomo
V
V
D000374:Aggression / Q000187:drug effects; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D005333:Fetus / Q000187:drug effects*; D008425:Maternal Behavior; D051379:Mice; D009420:Nervous System / Q000187:drug effects*; D011247:Pregnancy; D051381:Rats; D014828:Vocalization, Animal / Q000187:drug effects