Cavitating Pneumocystis pneumonia in an autopsied case of adult T-cell leukemia.
Cavitating necrosis is rare in Pneumocystis carinii pneumonia. In this report, we describe an autopsy patient with adult T-cell leukemia associated with cavitating Pneumocystis carinii pneumonia. The patient, a 61-year-old woman, died of an acute crisis of adult T-cell leukemia associated with diffuse pulmonary infection of Pneumocystis carinii. Postmortem examination revealed necrotic foci in both lungs, one of which, in the left lower lobe, had a central cavitation. Microscopically, leukemic cell infiltration was abundant in the lung parenchyma but not in the necrotic lesions. Pneumocystis carinii organisms were distributed diffusely in the alveoli and also in the cavity wall. Intranuclear and intracytoplasmic inclusion bodies were scattered in the lung indicating cytomegalovirus infection. However, no bacterial or fungal infection was detected in the lungs, even in the necrotic lesions. Cavitating Pneumocystis carinii pneumonia occurs in other immunodeficiency diseases apart from AIDS. To our knowledge, this report is the first case of cavitating Pneumocystis carinii pneumonia in adult T-cell leukemia.
Marutsuka
K
K
First Department of Pathology, Miyazaki Medical College, Japan.
Suzumiya
J
J
Sumiyoshi
A
A
D001752:Blast Crisis / Q000150:complications / Q000473:pathology; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications* / Q000473:pathology; D008168:Lung / Q000473:pathology; D008875:Middle Aged; D009336:Necrosis; D009894:Opportunistic Infections / Q000150:complications* / Q000473:pathology; D011020:Pneumonia, Pneumocystis / Q000150:complications* / Q000473:pathology