Improved detection of homology in distantly related proteins: similarity of adducin with actin-binding proteins.
A novel and generally applicable method is described for the detection of homology in distantly related proteins using a new domain sequence database that contains over 20,000 protein sequence segments of known function. The use of the method is illustrated on distantly related domains shared by complement components C1S and C1R, calcium-dependent serine proteinase and bone morphogenetic protein 1. New homologies are shown between human adducin and the actin-binding domains of alfa-actinin and dystrophin.
Simon
G
G
International Centre for Genetic Engineering and Biotechnology, Trieste, Italy.
Paladini
R
R
Tisminetzky
S
S
Cserzö
M
M
Hátsági
Z
Z
Tossi
A
A
Pongor
S
S
D000185:Actinin / Q000235:genetics; D000595:Amino Acid Sequence; D001798:Blood Proteins / Q000235:genetics; D002148:Calmodulin-Binding Proteins / Q000235:genetics*; D016384:Consensus Sequence; D016208:Databases, Factual; D003658:Decision Making, Computer-Assisted; D016189:Dystrophin / Q000235:genetics; D008432:Mathematical Computing; D008840:Microfilament Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D011487:Protein Conformation; D016415:Sequence Alignment / Q000379:methods*; D017386:Sequence Homology, Amino Acid; D012984:Software; D000099291:Adducins
D000185:Actinin; D001798:Blood Proteins; D002148:Calmodulin-Binding Proteins; D016189:Dystrophin; D008840:Microfilament Proteins; D000099291:Adducins