title: Deposition of loosely bound and firmly bound fluorides on tooth enamel by an acidic gel containing fluorosilicate and monocalcium phosphate monohydrate.
abstract: The amounts of loosely bound fluoride (F) deposited on human enamel by 4-min and 2-hour treatments with either acidulated phosphate fluoride (APF) or a monocalcium phosphate monohydrate and sodium hexafluorosilicate (MCPM-SHFS)-containing gel were measured with the use of a constant-composition F washing method. Enamel biopsies conducted before treatment and after washing were used to determine the firmly bound F uptake. The results showed that the MCPM-SHFS treatments produced significantly more loosely bound F than did the APF treatments. The 4-min treatment with either APF or MCPM-SHFS did not produce significant firmly bound F deposition, but the 2-hour treatments did, with that produced by MCPM-SHFS being significantly greater. The MCPM-SHFS gel, which had the same F content as APF and which may be applied to the proximal tooth surfaces in vivo without the use of a tray, has the potential to be more efficacious than APF because it deposits greater amounts of both loosely bound and firmly bound F.
authors: American Dental Association Health Foundation, Paffenbarger Research Center, National Institute of Standards and Technology, Gaithersburg, Md. 20899.
authors: S
authors: S
authors: Takagi
authors: L C
authors: LC
authors: Chow
authors: B A
authors: BA
authors: Sieck
mesh_terms: D000149:Acidulated Phosphate Fluoride / Q000008:administration & dosage / Q000737:chemistry; D002124:Calcium Fluoride / Q000737:chemistry; D002130:Calcium Phosphates / Q000008:administration & dosage / Q000737:chemistry*; D003743:Dental Enamel / Q000737:chemistry / Q000378:metabolism* / Q000648:ultrastructure; D005459:Fluorides / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry* / Q000493:pharmacokinetics*; D005460:Fluorides, Topical / Q000737:chemistry; D005782:Gels; D006801:Humans; D008855:Microscopy, Electron, Scanning; D012824:Silicic Acid / Q000008:administration & dosage / Q000737:chemistry*; D013997:Time Factors
chemical_list: D002130:Calcium Phosphates; D005460:Fluorides, Topical; D005782:Gels; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; D012824:Silicic Acid; C004832:hexafluorosilicate; D000149:Acidulated Phosphate Fluoride; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous; D002124:Calcium Fluoride; D005459:Fluorides