title: Mechanical stress and osteogenesis in vitro.
abstract: The use of hydrostatic pressure to apply mechanical stress to bone organ cultures is reviewed. Ossifying long bones and calvarial rudiments are sensitive to this type of stress. Intermittent hydrostatic compression of near physiologic magnitude (ICF) has anabolic effects on mineral metabolism in such rudiments, and continuous hydrostatic stress of high magnitude (CCP) has catabolic effects. The effects of ICF may be ascribed to shear stress generated at tissue interphases of different chemical and mechanical properties. Local factors, such as prostaglandins and growth factors, seem to be involved in the tissue response to mechanical stress.
authors: Department of Oral Cell Biology, Vrije Universiteit, Amsterdam, The Netherlands.
authors: E H
authors: EH
authors: Burger
authors: J
authors: J
authors: Klein-Nulend
authors: J P
authors: JP
authors: Veldhuijzen
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001842:Bone and Bones / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D006133:Growth Substances / Q000378:metabolism; D006874:Hydrostatic Pressure; D051379:Mice; D009924:Organ Culture Techniques; D010012:Osteogenesis / Q000502:physiology*; D011453:Prostaglandins / Q000378:metabolism; D013314:Stress, Mechanical
chemical_list: D006133:Growth Substances; D011453:Prostaglandins; D002118:Calcium