[Coronary heart disease and silent myocardial ischemia].
Silent myocardial ischemia was studied in 100 patients with coronary heart disease (CHD), proved by the coronary arteriogram (at least one major coronary artery narrowed by > or = 50%). The study demonstrated that 51 of 100 patients with CHD had episodes of myocardial ischemia by Holter monitoring. In the 51 patients, during daily activities, through 24-hour Holter monitoring, 239 transient episodes of ST depression were detected, 161 of the total were asymptomatic (67.4%). There were no statistically significant differences in the heart rate and the product of heart rate and systolic blood pressure before ST depression between asymptomatic and symptomatic episodes. The heart rate at the time of maximal ST depression during both asymptomatic and symptomatic ischemia increased by 13 and 22 beats/min, respectively, over those before ST depression (P < 0.01); whereas the increase in heart rate during symptomatic ischemia was more significant than during asymptomatic ischemia (P < 0.01). The increase of product of heart rate and systolic blood pressure at the time of maximal ST depression during asymptomatic and symptomatic ischemia were 22.2 and 35.4, respectively, over those before ST depression (P < 0.01). The incidence of silent ischemic episodes in patients with single vessel disease was 81.7% and those with multivessel disease was 61.3% (P < 0.01). The frequency of silent ischemic episodes was maximal (36% of total number of ischemic episodes) between 6 a.m. and 12 a.m. during 24-hour, whereas the incidence of silent ischemic episodes in patients with single vessel disease was similar to that in patients with multivessel disease.(ABSTRACT TRUNCATED AT 250 WORDS)
Xu
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Cardiovascular Institute, CAMS, Beijing.
D000328:Adult; D000368:Aged; D002940:Circadian Rhythm; D017023:Coronary Angiography; D003327:Coronary Disease / Q000503:physiopathology*; D015716:Electrocardiography, Ambulatory; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000145:classification / Q000503:physiopathology*