title: [The favorable effect of hydrolytic enzymes in the treatment of immunocytomas and plasmacytomas].
abstract: At present attention is focused on research of biomodulating influences on tumorous processes, in particular inhibition of metastatic spread of tumors. In the aetiopathogenesis an important part is played by immune complexes, interaction of cytokines. The authors tested the supporting effect of hydrolytic enzymes in plasmocytoma and immunocytoma. The enzymes were administered along with cytostatic preparations according to the MOCCA pattern. They recorded a more rapid onset and longer persistence of remissions, a marked decline of total proteins, paraproteins, beta-2-microglobulin. Complications associated with paraprotein (hyperviscosity syndrome, nephrotic syndrome, peripheral angiopathy) improved. A combination of chemotherapy and enzymatic treatment proved effective and suitable, in particular for patients with interferon intolerance.
authors: I. interná klinika Fakultnej nemocnice, Bratislava.
authors: A
authors: A
authors: Sakalová
authors: M
authors: M
authors: Mikulecký
authors: D
authors: D
authors: Holománová
authors: D
authors: D
authors: Langner
authors: K
authors: K
authors: Ransberger
authors: G
authors: G
authors: Stauder
authors: M
authors: M
authors: Mistrík
authors: S
authors: S
authors: Gazová
authors: I
authors: I
authors: Chabronová
authors: M
authors: M
authors: Benzová
mesh_terms: D002918:Chymotrypsin; D004338:Drug Combinations; D006801:Humans; D006867:Hydrolases / Q000627:therapeutic use*; D010184:Pancreatic Extracts / Q000627:therapeutic use*; D010206:Papain / Q000627:therapeutic use*; D010265:Paraproteinemias / Q000628:therapy*; D010954:Plasmacytoma / Q000628:therapy*; D012431:Rutin / Q000627:therapeutic use*; D013949:Thymus Extracts / Q000627:therapeutic use*; D014357:Trypsin
chemical_list: D004338:Drug Combinations; D010184:Pancreatic Extracts; D013949:Thymus Extracts; D012431:Rutin; C009685:chymotrypsin, papain, trypsin drug combination; C023295:Wobenzym; D006867:Hydrolases; D002918:Chymotrypsin; D014357:Trypsin; D010206:Papain
vernacular_title: Podporný úcinok hydrolytickych enzýmov pri liecbe imunocytómu a plazmocytómu.