Immunological and clinical effect of long-term oral treatment with RU 41740 in patients with chronic bronchitis: double-blind trial long-term versus standard dose regimen.
The immunological and clinical effects of two oral treatment schedules of RU 41740 (standard for 3 months vs. long-term for 6 months) were assessed in 40 patients with chronic bronchitis by a controlled, double-blind, randomized trial. Both treatments significantly improved phagocytosis index of both neutrophils and monocytes, and the phagocytosis frequency and the candidacidal activity of neutrophils, showing the maximum stimulation at the end of the third course of treatment. Both treatment schedules reduced the number and the duration of infectious exacerbations of chronic bronchitis with respect to those observed in the corresponding period of the previous year. However, no significant difference between standard and long-term treatment with RU 41740 was found with respect to the immunological and clinical effect and tolerability.
Fietta
A M
AM
Chair of Chemotherapy, University of Pavia, IRCCS, Policlinico S. Matteo, Italy.
Merlini
C
C
Uccelli
M
M
Gialdroni Grassi
G
G
Grassi
C
C
D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D001426:Bacterial Proteins / Q000008:administration & dosage / Q000627:therapeutic use*; D001991:Bronchitis / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology*; D002908:Chronic Disease; D004306:Dose-Response Relationship, Immunologic; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010587:Phagocytosis; D013997:Time Factors
D001426:Bacterial Proteins; C037567:glycoprotein, Klebsiella pneumoniae