Liver blood flow: non-invasive estimation using a gamma camera.
A non-invasive radioisotope technique for the measurement of total liver blood flow (TBF) is described. The method requires the use of two intravenously administered tracers, 99mTc (technetium 99m) human serum albumin (HSA) and 99mTc colloid. Computer analysis of first-pass time activity curves for HSA for liver and lung tissues yields values for the arterial and portal contributions to liver blood flow, from which TBF can be determined. These values are then corrected for attenuation using the images of the colloid distribution. The use of the method is illustrated in 17 subjects. Assumptions, limitations and possible applications of the technique are discussed.
Tindale
W B
WB
Department of Medical Physics, Royal Hallamshire Hospital, Sheffield.
Barber
D C
DC
Smart
H L
HL
Triger
D R
DR
D003102:Colloids; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging*; D008102:Liver Circulation; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D011877:Radionuclide Imaging; D012016:Reference Values; D013667:Technetium; D017556:Technetium Compounds; D013668:Technetium Tc 99m Aggregated Albumin; D014001:Tin; D017971:Tin Compounds
D003102:Colloids; D017556:Technetium Compounds; D013668:Technetium Tc 99m Aggregated Albumin; D017971:Tin Compounds; C033493:technetium Tc 99m tin colloid; D013667:Technetium; D014001:Tin