Necrobiotic xanthogranuloma in a human T-lymphotropic virus type 1 carrier.
A 67-year-old man who had necrobiotic xanthogranuloma associated with paraproteinemia is described. He was a human T-lymphotropic virus type 1 (HTLV-1) carrier who had a high titer of circulating anti-HTLV-1 antibodies and neurologic abnormalities that suggested HTLV-1-associated myelopathy. The patient's necrobiotic xanthogranuloma and neurologic symptoms improved after he received four 5-day courses of melphalan, 2 mg/day, and prednisolone, 20 mg/day, at 4-week intervals.
Nishimura
M
M
Department of Clinical Genetics, Kyushu University, Beppu, Japan.
Takano-Nishimura
Y
Y
Yano
I
I
Hayashi
N
N
Toshitani
S
S
D000368:Aged; D006099:Granuloma / Q000276:immunology / Q000473:pathology*; D015481:HTLV-I Antibodies / Q000032:analysis; D015490:HTLV-I Infections / Q000276:immunology / Q000473:pathology*; D006801:Humans; D008297:Male; D017441:Necrobiotic Disorders / Q000276:immunology / Q000473:pathology*; D010265:Paraproteinemias; D014973:Xanthomatosis / Q000276:immunology / Q000473:pathology*
D015481:HTLV-I Antibodies