title: Dicyclomine for medical management of persistent anal fissure with associated spasm of the internal sphincter.
abstract: The case of a 43-year-old woman with persistent anal fissure responsive to dicyclomine is described. Associated spasm of the internal sphincter had precluded fissure healing. The spasm of the internal sphincter relaxed within 24 hours of dicyclomine administration and subsequently allowed healing. Surgery was avoided.
authors: Department of Family Medicine, Baylor College of Medicine, Houston, Tex.
authors: L G
authors: LG
authors: Miller
authors: J C
authors: JC
authors: Rogers
authors: E B
authors: EB
authors: Brown
authors: G
authors: G
authors: Perkins
mesh_terms: D000328:Adult; D004025:Dicyclomine / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005401:Fissure in Ano / Q000188:drug therapy*; D006801:Humans; D013035:Spasm / Q000188:drug therapy*
chemical_list: D004025:Dicyclomine