Congenital defects of the limbs and alcohol exposure in pregnancy: data from a population based study.
Limb deficiency may occur in offspring prenatally exposed to alcohol. In a study on limb deficiency occurring in 1,213,913 consecutive liveborn infants in British Columbia, born in the years 1952-1984, a total of 659 cases with limb deficiency was identified. Cases with documented maternal alcohol abuse in pregnancy in this group were analyzed separately. We found eight cases with severe prenatal alcohol exposure (6 F, 2 M). In six of the eight cases a terminal transverse defect of the forearm or hand was present. In the remaining two cases ulnar defects were identified. These observations give further support to the hypothesis that intrauterine alcohol exposure may cause limb defects. This has also been demonstrated in experimental animals. Terminal transverse defects made up a larger proportion of cases with known alcohol exposure (6/8) than of cases where alcohol exposure was not noted (217/651) (chi 2 = 6.13; P < 0.025) in this study. The defects primarily involved the right hand and forearm. This suggests a vascular origin of the limb defects after intrauterine alcohol exposure.
Froster
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UG
Klinik für Frauenheilkunde und Geburtshilfe, Medizinische Universität zu Lübeck, Germany.
Baird
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PA
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology*; D000015:Abnormalities, Multiple / Q000453:epidemiology / Q000209:etiology; D000437:Alcoholism / Q000453:epidemiology; D000818:Animals; D001955:British Columbia / Q000453:epidemiology; D003042:Cocaine / Q000009:adverse effects; D015331:Cohort Studies; D000431:Ethanol / Q000009:adverse effects*; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000453:epidemiology*; D005313:Fetal Death / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D017880:Limb Deformities, Congenital; D008297:Male; D051379:Mice; D011247:Pregnancy; D011248:Pregnancy Complications; D015995:Prevalence; D013792:Thalidomide / Q000009:adverse effects
D000431:Ethanol; D013792:Thalidomide; D003042:Cocaine