Hydrogels for site-specific drug delivery to the colon: in vitro and in vivo degradation.
Novel hydrogels based on N,N-dimethylacrylamide, N-t-butylacrylamide, and acrylic acid cross-linked with azoaromatic compounds of varying length and electron density of the azo bond were synthesized. The cross-links are degradable by microbial azoreductases present predominantly in the colon, and the gels appear to be suitable for colon-specific drug delivery. The degradability in vitro and in vivo was found to be related to the degree of swelling of the gels. The higher the degree of swelling, the higher the degradability. However, structural and electronic factors were also shown to influence reduction of azo bonds.
Brøndsted
H
H
Department of Pharmaceutics/CCCD, University of Utah, Salt Lake City 84112.
Kopecek
J
J
D000178:Acrylamides; D000818:Animals; D003106:Colon; D003432:Cross-Linking Reagents / Q000737:chemistry / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D005612:Freeze Drying; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D066298:In Vitro Techniques; D008297:Male; D011092:Polyethylene Glycols; D051381:Rats; D017207:Rats, Sprague-Dawley
D000178:Acrylamides; D003432:Cross-Linking Reagents; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols