[Pathological and immunohistochemical study on 63 cases of brain metastases from the lung].
Pathologic analysis of 63 cases of brain metastases from lung was reported. The specimens of all cases were labelled by 4 antibodies (HLC3-AB, CEA, Keratin, GFAP), by means of ABC method. According to our data, brain metastases from lung accounted for 50.4% of whole brain metastases. Lobus frontalis was the most common intracranial metastatic site of lung cancer. Four histopathological types were classified: adenocarcinoma (55.6%), undifferentiated carcinoma (17.4%), adenosquamous carcinoma (14.3%) and squamous cell carcinoma (12.7%). The immunohistochemical results showed that HLC3-AB is a helpful marker in identifying brain metastases from lung cancer. GFAP showed negative in malignant cells but positive in stroma. This result suggested that the stroma of brain metastases contains ingredients originating from astro-gliofibre.
Zhang
J
J
Hubei Cancer Hospital, Wuhan.
D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology / Q000556:secondary*; D000328:Adult; D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology / Q000556:secondary*; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology / Q000556:secondary; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology / Q000556:secondary; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D005904:Glial Fibrillary Acidic Protein