title: Polyadenylic-polyuridylic acid as an adjuvant in resectable colorectal carcinoma: a 6 1/2 year follow-up analysis of a multicentric double blind randomized trial.
abstract: In a double blind study, patients with operable carcinoma of the colon and the upper rectum, who have undergone a macroscopically complete resection of their tumor, were randomized to receive either (i) polyadenylic-polyuridylic acid (AU), one i.v. injection of 60 mg (in 50 ml of solution) once a week for 6 weeks, or (ii) a placebo (P) one i.v. injection of 50 ml of a saline solution with the same schedule. From January 1983 to December 1986, 288 patients were enrolled: 145 in AU group and 143 in P group. The main clinical and pathological characteristics were equally distributed throughout the two groups. There was a significant difference (P < 0.02) in the overall survival (OS) between the two groups, in favor of the P group. The 5-year OS rate was 68% (SD = 4%) in the AU group versus 81% (SD = 3%) in the P group. Thus, AU as a single adjuvant, appears to be ineffective and therefore has no indication in the treatment of colorectal carcinoma.
authors: Institut Gustave-Roussy, Villejuif, France.
authors: J
authors: J
authors: Lacour
authors: A
authors: A
authors: Laplanche
authors: M
authors: M
authors: Malafosse
authors: D
authors: D
authors: Gallot
authors: M
authors: M
authors: Julien
authors: N
authors: N
authors: Rotman
authors: M
authors: M
authors: Guivarc'h
authors: J C
authors: JC
authors: Roullet-Audy
authors: P
authors: P
authors: Lasser
authors: P
authors: P
authors: Hautefeuille
mesh_terms: D000368:Aged; D017024:Chemotherapy, Adjuvant; D016009:Chi-Square Distribution; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000601:surgery; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D011063:Poly A-U / Q000627:therapeutic use*; D012044:Regression Analysis; D016019:Survival Analysis
chemical_list: D011063:Poly A-U