title: Palm carotene inhibits tumor-promoting activity of bile acids and intestinal carcinogenesis.
abstract: The effects of palm carotene on chemical carcinogenesis was studied. Palm carotene suppressed mouse epidermal ornithine decarboxylase activity induced by glycocholic acid. In a two-stage mouse epidermal carcinogenesis experiment using 7,12-dimethylbenz(a)anthracene as the initiator, glycocholic acid as the 1st stage promoter, and mezerein as the 2nd stage promoter, palm carotene inhibited the promoting activity of glycocholic acid. Furthermore, in N-ethyl-N'-nitro-N-nitrosoguanidine-induced mouse duodenal carcinogenesis, 0.05% of palm carotene given in drinking water decreased the percentage of tumor-bearing mice significantly.
authors: 1st Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
authors: J
authors: J
authors: Okuzumi
authors: H
authors: H
authors: Nishino
authors: M
authors: M
authors: Murakoshi
authors: T
authors: T
authors: Yamane
authors: Y
authors: Y
authors: Kitao
authors: M
authors: M
authors: Inagake
authors: K
authors: K
authors: Ohya
authors: M
authors: M
authors: Yoshida
authors: T
authors: T
authors: Takahashi
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D002338:Carotenoids / Q000627:therapeutic use*; D004224:Diterpenes; D004379:Duodenal Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D006000:Glycocholic Acid / Q000633:toxicity*; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000031:analogs & derivatives; D051379:Mice; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D009955:Ornithine Decarboxylase / Q000032:analysis; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013729:Terpenes / Q000633:toxicity
chemical_list: D002273:Carcinogens; D004224:Diterpenes; D013729:Terpenes; D008769:Methylnitronitrosoguanidine; C011309:mezerein; D002338:Carotenoids; C013525:ENNG; D015127:9,10-Dimethyl-1,2-benzanthracene; D009955:Ornithine Decarboxylase; D006000:Glycocholic Acid