[Synthesis of new pyrimidine 5'-H-thiophosphonates].
Thymidine and 3'-deoxythymidine 5'-H-thiophosphonates were synthesized by interaction of 3'-O-acetylthymidine or 3'-deoxythymidine and ammonium phosphinate in the presence of pivaloyl chloride and following oxidation in situ by sulfur of the intermediate phosphinates. The compounds seemed to be 1:1 mixture of diastereomers with chiral phosphorus. The prepared compounds were tested as potential inhibitors of HIV production.
Shirokova
E A
EA
D000998:Antiviral Agents / Q000138:chemical synthesis*; D006678:HIV; D009946:Organothiophosphorus Compounds / Q000138:chemical synthesis*; D011743:Pyrimidines / Q000737:chemistry*; D013237:Stereoisomerism
D000998:Antiviral Agents; D009946:Organothiophosphorus Compounds; D011743:Pyrimidines
Sintez novykh 5'-H-tiofosfonatov pirimidinov.