Quinolinic acid in culture media used for in vitro neurotoxicology studies.
Serum from several species is frequently added to the incubation media of cells in vitro. The excitotoxin and N-methyl-D-aspartate receptor agonist quinolinic acid was found to be present in serum in concentrations ranging from 59 to 4895 nM. Some neuronal systems are reported to be particularly sensitive to the neurotoxic effects of quinolinic acid. Therefore, quinolinic acid in serum should be considered as a potentially confounding variable in neurotoxicology studies in vitro.
Heyes
M P
MP
Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD 20892.
D000818:Animals; D002417:Cattle; D002645:Chickens; D003470:Culture Media; D006041:Goats; D006736:Horses; D006801:Humans; D051379:Mice; D009422:Nervous System Diseases / Q000139:chemically induced*; D017378:Quinolinic Acid / Q000097:blood* / Q000633:toxicity; D011817:Rabbits; D051381:Rats; D012756:Sheep; D013552:Swine
D003470:Culture Media; D017378:Quinolinic Acid