title: Monoclonal gammopathy in a 30 weeks old premature infant.
abstract: The occurrence of monoclonal gammopathy in childhood is extremely rare. This report describes the presence of a monoclonal immunoglobulin in a 30 week old premature infant, incidentally discovered by two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) during an ongoing study of the plasma/serum protein development. Comparative analysis of the electrophoretogram of the infant with 'reference' protein maps revealed the presence of an 'abnormal' immunoglobulin light chain spot. A spot having an identical apparent molecular weight and isoelectric point was also detected after 2D-PAGE of the mother's plasma and its Protein-A purified immunoglobulin fraction. The observation of a monoclonal gammopathy in a premature infant, most likely transmitted from his mother, highlights the potential usefulness of 2D-PAGE in the clinical laboratory.
authors: Centre de Transfusion Sanguine CRS, Lausanne, Switzerland.
authors: J D
authors: JD
authors: Tissot
authors: P
authors: P
authors: Schneider
authors: P
authors: P
authors: Hohlfeld
authors: J F
authors: JF
authors: Tolsa
authors: A
authors: A
authors: Calame
authors: D F
authors: DF
authors: Hochstrasser
mesh_terms: D001797:Blood Protein Electrophoresis; D015180:Electrophoresis, Gel, Two-Dimensional; D005260:Female; D006801:Humans; D007146:Immunoglobulin lambda-Chains / Q000097:blood*; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D008431:Maternal-Fetal Exchange; D010265:Paraproteinemias / Q000097:blood; D010266:Paraproteins / Q000032:analysis*; D011247:Pregnancy; D011644:Puerperal Disorders / Q000097:blood*
chemical_list: D007146:Immunoglobulin lambda-Chains; D010266:Paraproteins