Role of type 1 and type 2 T helper cells in allergic diseases.
Various characteristics of atopic allergic disorders seem to be causally related with the activation of allergen-specific T helper lymphocytes with a type 2 cytokine secretion profile, including high levels of interleukin-4 and interleukin-5. These cytokines are responsible for the occurrence of elevated levels of serum allergen-specific IgE and eosinophilia and play an important role in local inflammatory reactions.
Kapsenberg
M L
ML
Laboratory of Cell Biology and Histology, University of Amsterdam, The Netherlands.
Jansen
H M
HM
Bos
J D
JD
Wierenga
E A
EA
D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007073:Immunoglobulin E / Q000096:biosynthesis; D007249:Inflammation / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000502:physiology; D006377:T-Lymphocytes, Helper-Inducer / Q000502:physiology*
D007073:Immunoglobulin E