title: Role of type 1 and type 2 T helper cells in allergic diseases.
abstract: Various characteristics of atopic allergic disorders seem to be causally related with the activation of allergen-specific T helper lymphocytes with a type 2 cytokine secretion profile, including high levels of interleukin-4 and interleukin-5. These cytokines are responsible for the occurrence of elevated levels of serum allergen-specific IgE and eosinophilia and play an important role in local inflammatory reactions.
authors: Laboratory of Cell Biology and Histology, University of Amsterdam, The Netherlands.
authors: M L
authors: ML
authors: Kapsenberg
authors: H M
authors: HM
authors: Jansen
authors: J D
authors: JD
authors: Bos
authors: E A
authors: EA
authors: Wierenga
mesh_terms: D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007073:Immunoglobulin E / Q000096:biosynthesis; D007249:Inflammation / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000502:physiology; D006377:T-Lymphocytes, Helper-Inducer / Q000502:physiology*
chemical_list: D007073:Immunoglobulin E