Modulatory influences of estrogen and progesterone on cervical dysplasia in mice model system.
The effectiveness of estrogen and progesterone on the different types of cervical dysplasia are poorly documented compared to their effects on the total process of cervical carcinogenesis. In the present study, an attempt has been made to evaluate the influences of estrogen and progesterone on the different types of cervical dysplasia which are believed to be the antecedents of cervical carcinoma induced by chemical carcinogen (20-Methy cholanthrene) in the mice model system. It was observed that moderate dysplasia is less aberrant than that of marked dysplasia which could not be modified by either of the hormones.
Sengupta
A
A
Chittaranjan National Cancer Institute, Department of Experimental Carcinology, Calcutta, India.
Dutta
S
S
Mallick
R
R
D000818:Animals; D001551:Benz(a)Anthracenes; D002273:Carcinogens; D004357:Drug Synergism; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D010052:Ovariectomy; D011374:Progesterone / Q000494:pharmacology*; D002578:Uterine Cervical Dysplasia / Q000139:chemically induced / Q000473:pathology* / Q000517:prevention & control
D001551:Benz(a)Anthracenes; D002273:Carcinogens; D004967:Estrogens; C053714:cholanthrene; D011374:Progesterone