Protective effect of intradermal BCG against leprosy; a case-control study in central Brazil.
A case-control study was undertaken to evaluate the protective efficacy of intradermal BCG against leprosy in a high-endemic area of leprosy in central Brazil. Sixty-two cases and 186 controls were included in the study. Cases were all newly diagnosed leprosy patients under 16 years of age attending an outpatient health service, and all of them were schoolchildren. Three controls under 16 years old, frequency matched by sex and age group, were selected from schools geographically located in the area from which the cases came. The presence of BCG was negatively associated with leprosy, indicating a 5.3 risk of leprosy for those nonvaccinated and protective efficacy of 81%. Paucibacillary patients were more likely to have a BCG scar than multibacillary patients.
Rodrigues
M L
ML
Public Health Department, Universidade Federal de Goias, Brazil.
Silva
S A
SA
Neto
J C
JC
de Andrade
A L
AL
Martelli
C M
CM
Zicker
F
F
D000293:Adolescent; D001500:BCG Vaccine / Q000627:therapeutic use*; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007271:Injections, Intradermal; D007918:Leprosy / Q000453:epidemiology / Q000517:prevention & control*; D008297:Male; D015995:Prevalence; D012882:Skin Tests; D014611:Vaccination
D001500:BCG Vaccine