Choleretic effects of alpha-iridodiol on experimentally induced intrahepatic cholestasis.
When a lymphokine, the cholestatic factor, was intravenously injected into rats through a mesenteric vein, a remarkable reduction in bile flow was observed. Using this experimentally induced intrahepatic cholestasis model, we studied the choleretic effects of alpha-iridodiol, an iridoid compound. When alpha-iridodiol was administered 30 min before, at the same time, or 30 min after injection of the cholestatic factor, the reductions in bile flow and bile acid excretion were significantly inhibited. Remarkable choleretic effects were also noted when it was administered to normal rats. These results suggested that alpha-iridodiol may be effective in the treatment of intrahepatic cholestasis.
Mizoguchi
Y
Y
Third Department of Internal Medicine, Osaka City University Medical School, Japan.
Sakagami
C
C
Ichikawa
Y
Y
Kobayashi
K
K
D000818:Animals; D002756:Cholagogues and Choleretics / Q000494:pharmacology*; D002780:Cholestasis, Intrahepatic / Q000188:drug therapy*; D003517:Cyclopentanes / Q000737:chemistry / Q000494:pharmacology*; D006168:Guinea Pigs; D039823:Iridoids; D015394:Molecular Structure; D051381:Rats
D002756:Cholagogues and Choleretics; D003517:Cyclopentanes; D039823:Iridoids; C078796:iridodiol