Effect of epidermal growth factor on ulcerative mucositis in hamsters that receive cancer chemotherapy.
Ulcerative mucositis is a common, bothersome, and dose-limiting complication of cancer chemotherapy. It has been hypothesized that mucosal susceptibility to the degenerative effects of stomatotoxic drugs is related to the renewal rate of the buccal epithelium. This study was undertaken to evaluate the effect of epidermal growth factor, a molecule known to stimulate epidermal cell division, on the course, frequency, and healing of ulcerative mucositis in an animal model. Golden Syrian hamsters were subjected to a standard mucositis-induction protocol with 5-fluorouracil. Osmotic pumps were implanted into a space between the retractor muscle and the platysma cervicale muscle, and delivered epidermal growth factor or placebo at a constant rate for 7 or 14 days. Epidermal growth factor increased oral mucosal breakdown in the face of antineoplastic therapy. The course and extent of mucositis was influenced by the timing of epidermal growth factor pump placement relative to the initiation of stomatotoxic therapy. These results support the hypothesis that the epithelial basal cell rate is one of the key elements in determining mucosal sensitivity to cancer chemotherapy.
Sonis
S T
ST
Division of Dentistry, Brigham & Women's Hospital, Harvard School of Dental Medicine, Boston, Mass.
Costa
J W
JW
Evitts
S M
SM
Lindquist
L E
LE
Nicolson
M
M
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D006224:Cricetinae; D004815:Epidermal Growth Factor / Q000008:administration & dosage / Q000633:toxicity*; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D005472:Fluorouracil / Q000633:toxicity; D015918:Infusion Pumps, Implantable; D008297:Male; D008647:Mesocricetus; D009061:Mouth Mucosa / Q000187:drug effects*; D013280:Stomatitis / Q000139:chemically induced*; D013997:Time Factors; D014456:Ulcer / Q000139:chemically induced
D004815:Epidermal Growth Factor; D005472:Fluorouracil