title: Risk of ventricular dysrhythmias during 1-hour infusions of amphotericin B in patients with preserved renal function.
abstract: In order to assess the safety of 1-h infusions of amphotericin B (AMB), we prospectively monitored 213 1-h infusions of AMB (dose range, 0.27 to 0.89 mg/kg of body weight) in 27 patients with creatinine clearances of > 25 ml/min. Holter monitor tracings during 1-h infusions were compared with those during a 4-h baseline period of monitoring. There were no ventricular dysrhythmias during 1-h infusions of AMB that were not present during baseline monitoring. Nausea and/or rigors were noted for 32 (15%) infusions in six (22%) patients. No patient exhibited a temperature rise of > 1 degree C. We conclude that, in doses of up to 0.9 mg/kg, AMB does not appear to induce asymptomatic ventricular dysrhythmias when administered over 1 h to patients with creatinine clearances of > 25 ml/min.
authors: Department of Internal Medicine (Infectious Disease Division and Cardiology Division), Naval Hospital, San Diego, California 92134-5000.
authors: W A
authors: WA
authors: Bowler
authors: P J
authors: PJ
authors: Weiss
authors: H E
authors: HE
authors: Hill
authors: K A
authors: KA
authors: Hoffmeister
authors: R P
authors: RP
authors: Fleck
authors: A R
authors: AR
authors: Blacky
authors: E C
authors: EC
authors: Oldfield
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000008:administration & dosage / Q000009:adverse effects*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D004334:Drug Administration Schedule; D015716:Electrocardiography, Ambulatory; D005260:Female; D006352:Heart Ventricles / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D007668:Kidney / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014693:Ventricular Fibrillation / Q000139:chemically induced; D016276:Ventricular Function / Q000187:drug effects*
chemical_list: D000666:Amphotericin B