[Tumor suppressor genes associated with development of human renal cell carcinoma].
Several rodent studies based on molecular biology have suggested that accumulation of genetic alterations in cancer-associated genes is required to convert a normal cell into a malignant cell. Activation of oncogenes and inactivation of tumor suppressor genes appear to be involved in carcinogenesis. In renal cell carcinomas, we have recently implied that the presence of tumor suppressor genes at chromosome 3p13-14.3 and 21.3, the regions where are also commonly deleted in adenocarcinoma of the lung; at chromosome 5q21, the region where the MCC (mutated in colorectal cancer) gene and APC (adenomatous polyposis coli) gene are located; at chromosome 6q27; and at 10q 21-23. We have also indicated that genes on 3p is probably important for development of RCCs and genes on 5q, 6q, and 10q may be associated with progression of RCCs.
Morita
R
R
Department of Genetic Research Laboratory, SRL Inc.
Hikiji
K
K
Yamakawa
K
K
Nakamura
Y
Y
D002292:Carcinoma, Renal Cell / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10; D002893:Chromosomes, Human, Pair 3; D002895:Chromosomes, Human, Pair 5; D002896:Chromosomes, Human, Pair 6; D016147:Genes, Tumor Suppressor; D006579:Heterozygote; D006801:Humans; D007680:Kidney Neoplasms / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D009857:Oncogenes