[Differentiating effect of oral administration of retinol palmitate (Chocola-A) for an aged AML (M3) with severe complications].
A 74 year-old woman, who had been diagnosed as AML (M3) in poor condition, was treated with Retinol Palmitate (Chocola-A, 150,000 unit/m2 per os, after informed consent. An increase of white blood cells (neutrophil) counts was observed after 7 days. After 4 weeks, WBC counts were increased to 20,700/microliters (neutrophil counts 6,400/microliters) Maturation tendency of leukemic cells was also proved in the bone marrow. In vitro studies showed that morphological differentiation was recognizable in cultured leukemic cells treated with 10(-6)M all-trans retinoic acid after 6 days, but not in controls. Responses in the NBT reduction test were slightly less than in the clinical study. The administration of Retinol Palmitate may be a new regimen to treat AML (M3) in aged patients in poor condition.
Nomura
J
J
Second Department of Internal Medicine, Tohoku University School of Medicine.
Endo
K
K
Furuyama
K
K
Harigae
H
H
Satou
A
A
Shishido
T
T
Okuda
M
M
Sugawara
T
T
Meguro
K
K
Fukuhara
O
O
D000284:Administration, Oral; D000368:Aged; D002454:Cell Differentiation / Q000187:drug effects; D004224:Diterpenes; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy* / Q000473:pathology; D000084562:Retinyl Esters; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000473:pathology; D014801:Vitamin A / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
D004224:Diterpenes; D000084562:Retinyl Esters; D014801:Vitamin A; C014794:retinol palmitate