title: Investigation of the dependence of human middle cerebral artery contractile activity on the presence of an atherosclerotic patch.
abstract: In some cases, human middle cerebral artery segments reacted to vasoconstrictor stimuli, including noradrenaline, KCL, prostaglandin F2 alpha, and activated platelets and neutrophils, by showing abnormally long-term contraction. All the segments were atherosclerotic, the atherosclerotic patch constricting the lumen to 30%-50%. Vasodilator concentrations that remove the ordinary contraction of vessels, only slightly limited the abnormal spastic reaction. A positive interaction between nifedipine and prostacyclin was revealed, and their combined use had a more marked anti-spasmatic effect than when these agents were used separately.
authors: Department of Pharmacology, Yerevan Medical Institute, Armenia.
authors: S E
authors: SE
authors: Akopov
authors: M R
authors: MR
authors: Grygorian
authors: E S
authors: ES
authors: Gabrielian
authors: B H
authors: BH
authors: Balayan
mesh_terms: D046508:Culture Techniques; D011464:Epoprostenol / Q000502:physiology; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000503:physiopathology*; D002546:Ischemic Attack, Transient / Q000503:physiopathology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000503:physiopathology*; D014655:Vascular Resistance / Q000187:drug effects / Q000502:physiology*; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D011464:Epoprostenol