[Comparison between the use of anti-secretory-component (sc) antibodies and anti-mucin-like-cancer-antigen (MCA) antibodies in the identification of cancer cells in serous effusions].
Evaluation between Antibodies SC and MCA in identification of carcinomatous cells in serous effusions. Authors have tested with MAbs MCA and SC twenty-seven cell-blocks from malignant effusions (epithelial neoplasms) in order to investigate the capacity of each antibody to discriminate neoplastic cells from mesothelial cells; moreover the two antibodies have been tested in relation to PAS-diastase test to verify their sensitivity to mucin detection. The "Chi square" statistical test demonstrates that MCA is much better than SC for sensitivity towards neoplastic cells, but that the SC is the best between two antibodies as markers of mucous producing features, and preferable to PAS-diastase test for better standardisation and interpretation.
Morea
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F
Servizio di Istopatologia, U.S.L. BA 18 di Putignano, Bari.
L'Abbate
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A
D000911:Antibodies, Monoclonal / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000032:analysis* / Q000276:immunology; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor / Q000032:analysis*; D005069:Evaluation Studies as Topic; D005122:Exudates and Transudates / Q000737:chemistry / Q000166:cytology*; D009077:Mucins / Q000032:analysis* / Q000276:immunology; D009363:Neoplasm Proteins / Q000032:analysis* / Q000276:immunology; D009369:Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology; D010503:Periodic Acid-Schiff Reaction; D011933:Reagent Kits, Diagnostic; D012635:Secretory Component / Q000032:analysis* / Q000276:immunology*; D012680:Sensitivity and Specificity
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D009077:Mucins; D009363:Neoplasm Proteins; D011933:Reagent Kits, Diagnostic; D012635:Secretory Component; C057387:mucinous carcinoma-associated antigen
Raffronto tra l'uso dell'anticorpo anti secretory component (sc) e dell'anticorpo anti mucinlike cancer antigen (MCA) nell'identificazione di cellule carcinomatose in versamenti sierosi.