Immunomodulatory activity of various fractions derived from Physalis angulata L extract.
The immunomodulatory effects of Physalis angulata L. extract fraction VII (PA-VII), PA-VII-A, PA-VII-B and PA-VII-C were investigated in this study. The results showed that PA-VII and PA-VII-C strongly enhanced blastogenesis response, PA-VII-B had moderate activity, and PA-VII-A exerted only slight effect on cell proliferation. A synergistic effect was observed when the suboptimal dosage of phytohemagglutinin (PHA) or lipopolysaccharide (LPS) was added to the culture. Furthermore, PA-VII and PA-VII-C possessed stimulatory activity on B cells and less effect on T cells. The antibody responses were also augmented by PA-VII, PA-VII-B and PA-VII-C, but not by PA-VII-A. The enhancement of antibody response could be observed both in BALB/c and C3H/HeJ mice.
Lin
Y S
YS
Department of Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan.
Chiang
H C
HC
Kan
W S
WS
Hone
E
E
Shih
S J
SJ
Won
M H
MH
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000145:classification / Q000276:immunology*; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000145:classification / Q000494:pharmacology*; D007783:Lactones / Q000737:chemistry / Q000145:classification / Q000276:immunology*; D008070:Lipopolysaccharides / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D010835:Phytohemagglutinins / Q000276:immunology; D012632:Secosteroids; D013256:Steroids
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D007783:Lactones; D008070:Lipopolysaccharides; D010835:Phytohemagglutinins; D012632:Secosteroids; D013256:Steroids; C075425:physalin F