The effect of haloperidol on aldosterone secretion.
Haloperidol (0.02 mg/kg, intravenous) did not stimulate aldosterone secretion in six normal controls or in six schizophrenic subjects. This is contrary to our hypothesis, which was based on the finding that peripheral D2 receptor antagonists stimulate aldosterone secretion, including haloperidol in rats and chlorpromazine in man. We speculated that a different dose of haloperidol would stimulate aldosterone in man. As expected, prolactin release was markedly stimulated in both groups of subjects, but no difference was found between groups.
Warner
M D
MD
Department of Psychiatry, Baylor Medical School, Houston, Texas.
Gillespie
H
H
Pavlou
S N
SN
Nader
S
S
Peabody
C A
CA
D000328:Adult; D000450:Aldosterone / Q000097:blood*; D006220:Haloperidol / Q000627:therapeutic use*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D012565:Schizophrenic Psychology
D000450:Aldosterone; D011388:Prolactin; D006220:Haloperidol