title: Susceptibility of African isolates of Plasmodium falciparum to artemisinin (qinghaosu).
abstract: We studied in vitro susceptibility of 79 African strains of Plasmodium falciparum to artemisinin, chloroquine, quinine, mefloquine and halofantrine and the potential cross-resistance among the drugs. Most strains presented an 50% inhibitory concentration (IC50) of artemisinin below 26 nmol/liter. A positive correlation between IC50S of artemisinin and those of quinine, mefloquine and halofantrine was observed. Cross resistance between artemisinin and other antimalarials may limit its use as a replacement drug.
authors: Centre d'Etude et de Recherche de Médecine Tropicale, Marseille, France.
authors: J C
authors: JC
authors: Doury
authors: P
authors: P
authors: Ringwald
authors: J
authors: J
authors: Guelain
authors: J
authors: J
authors: Le Bras
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins; D004351:Drug Resistance; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*; D012717:Sesquiterpenes / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes; C031327:artemisinin