Intracavitary ultrasound impairs left ventricular performance: presumed role of endocardial endothelium.
Irradiation of isolated cardiac muscle by high-power, high-frequency, continuous wave ultrasound selectively damages endocardial endothelium (EE). We evaluated this ultrasound effect in vivo on the performance of the intact ejecting canine left ventricle (LV). A cylindrical ultrasound probe (0.9 MHz, 25 W), mounted on a catheter, was inserted in the LV cavity through an apical stab wound and was activated for 60, 120, and 240 s, followed each time by a recovery period of 10-15 min. Ultrasound transiently and repeatedly abbreviated the time interval from end diastole to peak (-)dP/dt (from 241 +/- 30 to 229 +/- 32 ms after 240 s; P < 0.001), accelerated LV pressure fall, did not alter peak (+)-dP/dt or peak systolic pressure, increased diastolic and systolic segment lengths, and decreased fractional shortening. Microscopic analysis revealed dispersed granulocytes attached to the EE. EE cells were visibly damaged only in a limited area surrounding the probe. Accordingly, high-power, high-frequency, continuous wave ultrasound reversibly modulated LV performance, presumably by transient alteration of EE function.
Gillebert
T C
TC
Department of Physiology and Medicine, University of Antwerp, Belgium.
De Hert
S G
SG
Andries
L J
LJ
Jageneau
A H
AH
Brutsaert
D L
DL
D000818:Animals; D004285:Dogs; D004699:Endocardium / Q000502:physiology*; D004727:Endothelium / Q000502:physiology; D006439:Hemodynamics / Q000528:radiation effects; D008855:Microscopy, Electron, Scanning; D009206:Myocardium / Q000166:cytology / Q000648:ultrastructure; D014465:Ultrasonics; D016277:Ventricular Function, Left / Q000528:radiation effects*