title: Pharmacokinetic parameters from data relating to the plasma and biliary excretion kinetics of cefmetazole in rats.
abstract: The plasma disposition kinetics and the biliary excretion kinetics of cefmetazole after i.v. administration to rats anaesthetized with pentobarbital sodium were studied. Parametric estimation was carried out using non-linear regression methods with uni- and bivariate analyses. On the basis of statistical criteria a two-compartment model was chosen as the most appropriate for fitting the plasma concentration data, establishing a mean half-life value of the slow disposition phase at around 13 min. Analysis of the plasma and biliary data revealed a mean value for the biliary excretion constant of 0.049 l/min and 0.113 l/min for the urinary excretion constant. The cumulative biliary excretion data showed a mean value of 36.25% of the dose administered. The relationship between the biliary excretion rates and plasma concentrations seems to point to a saturable mechanism of excretion.
authors: Department of Pharmaceutics and Practical Pharmacy, University of Salamanca, Spain.
authors: M J
authors: MJ
authors: García-Agundez
authors: C
authors: C
authors: Fernández-Lastra
authors: R
authors: R
authors: Jiménez
authors: J
authors: J
authors: González
authors: E L
authors: EL
authors: Mariño
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001646:Bile / Q000378:metabolism; D001659:Biliary Tract / Q000378:metabolism*; D015311:Cefmetazole / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D008954:Models, Biological; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015311:Cefmetazole