No increase in carcinogen-DNA adducts in the lungs of monkeys exposed chronically to marijuana smoke.
Rhesus monkeys exposed to marijuana smoke either 7 or 2 days/weeks (HI and LO groups, respectively), or ethanol-extracted marijuana smoke for 7 days/week (EM) or sham treatment (SH) for 1 year were sacrificed 7 months following the last exposure. Pulmonary levels of carcinogen-DNA adducts were determined. Although mean or median adduct levels were not statistically different, 15 of 22 adduct measures were highest in the EM group and lowest 12 of 22 times in the SH group. The levels of aromatic carcinogen-DNA adducts seem no higher in the lungs of animals exposed to marijuana smoke than in untreated animals. Ethanol-extracted marijuana may have effects greater than marijuana itself.
Talaska
G
G
Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR.
Schamer
M
M
Bailey
J R
JR
Ali
S F
SF
Scallet
A C
AC
Slikker
W
W
Paule
M G
MG
D000818:Animals; D002186:Cannabinoids / Q000633:toxicity*; D002273:Carcinogens / Q000032:analysis*; D004247:DNA / Q000032:analysis*; D008168:Lung / Q000737:chemistry* / Q000187:drug effects; D008253:Macaca mulatta; D008385:Marijuana Smoking / Q000009:adverse effects; D012906:Smoke / Q000009:adverse effects*
D002186:Cannabinoids; D002273:Carcinogens; D012906:Smoke; D004247:DNA