title: Urinary fluoride excretion in children using potassium fluoride containing salt or sodium fluoride supplements.
abstract: With the introduction of fluoridated domestic salt in France in 1986, questions have arisen with respect to its efficacy in caries prevention. It has been of interest to compare the urinary excretion of fluoride in children who consume fluoridated salt to that in children who take fluoride tablets. Ninety-three schoolchildren, 10-14 years of age, participated in the study and were divided into four groups: group I consumed fluoridated salt with every meal; group II ate at a school restaurant once a day and consequently consumed fluoridated salt at only their evening meal, as fluoridated salt is not authorized for use in collective restaurants; group III consisted of children taking fluoride tablets (1.0 mg F/day) exclusively, and group IV did not receive any systemic administration of fluoride for prevention and constituted a low-fluoride control group. Total 24-hour urine samples were collected from all subjects. The average daily urinary flow rates varied from 0.51 to 0.68 ml/min, but showed no statistically significant differences among the groups. The average urinary fluoride concentrations were 0.60, 0.30, 0.99, and 0.28 mg/l, respectively, for groups I-IV. The mean 24-hour urinary fluoride concentrations and excretion rates for children who consumed fluoridated salt at all meals (group I) were not statistically different from those using tables (group III). There were also no statistically significant differences between groups II and IV. The differences between urinary fluoride concentrations and excretion rates of groups I and III, as compared with group IV, were statistically significant.
authors: Faculté de Chirurgie Dentaire, Université Louis Pasteur, Strasbourg, France.
authors: A M
authors: AM
authors: Obry-Musset
authors: D
authors: D
authors: Bettembourg
authors: P M
authors: PM
authors: Cahen
authors: J C
authors: JC
authors: Voegel
authors: R M
authors: RM
authors: Frank
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D001682:Biological Availability; D002648:Child; D003802:Dentifrices; D005459:Fluorides / Q000493:pharmacokinetics / Q000652:urine*; D005602:France; D006801:Humans; D011188:Potassium / Q000008:administration & dosage / Q000627:therapeutic use*; D017680:Potassium Compounds; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000627:therapeutic use*; D012982:Sodium, Dietary / Q000008:administration & dosage*; D013607:Tablets; D014554:Urination
chemical_list: D003802:Dentifrices; D017680:Potassium Compounds; D012982:Sodium, Dietary; D013607:Tablets; D012969:Sodium Fluoride; C033320:potassium fluoride; D005459:Fluorides; D011188:Potassium