[Acquired factor V inhibitor treated with intravenous immunoglobulins].
We report the appearance of a factor V inhibitor in an 82-year-old female patient following abdominal surgery. This anomaly was totally corrected following 9-day treatment with i.v. immunoglobulins (0.4 g/kg/day), which allowed a needed further surgical intervention to be performed without hemorrhagic diathesis. The activity of this inhibitor was partly reversed by the in vitro addition of immunoglobulins, suggesting a concentration-effect relationship. This finding supports the hypothesis that anti-idiotypic antibodies could play a role in the therapeutic effect of immunoglobulins in such situations.
Buclin
T
T
Département de médecine interne, CHUV, Lausanne.
Schmidt
P M
PM
Hauert
J
J
Winkel
L
L
Chapuis
G
G
Bachmann
F
F
D000368:Aged; D000369:Aged, 80 and over; D000888:Antibodies, Anti-Idiotypic; D001778:Blood Coagulation Disorders / Q000276:immunology / Q000628:therapy*; D001780:Blood Coagulation Tests; D005165:Factor V / Q000037:antagonists & inhibitors* / Q000276:immunology; D005260:Female; D006801:Humans; D007116:Immunization, Passive / Q000379:methods*; D007582:Jejunostomy; D011183:Postoperative Complications / Q000628:therapy
D000888:Antibodies, Anti-Idiotypic; D005165:Factor V
Inhibiteur acquis du facteur V traité par immunoglobulines intraveineuses.