Effects of septal lesions on a higher-order conditioned taste aversion: a preliminary analysis.
Septal-lesioned rats (n = 7) and nonsurgical controls (n = 7) were exposed to a higher-order conditioned taste aversion procedure and the effects of septal lesions on the development of a higher-order conditioned taste aversion examined. In Phase 1, septal and control rats were permitted to consume a sodium chloride solution and illness was produced by an injection of cyclophosphamide. Following a recovery period, in Phase 2, both groups were allowed access to a saccharin solution followed by 1 ml of sodium chloride placed directly inside the mouth of the rat. Subsequent preference tests for the septal-lesion group, the control group, and a second unconditioned control group (n = 5) showed the former two groups learned the higher-order conditioned taste aversion, as demonstrated by a marked aversion to the saccharin solution, and the septal lesions attenuated the severity of the conditioning process.
Compton
D M
DM
Department of Psychology, Georgia College, Milledgeville 31061.
Weed
J
J
D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D001921:Brain / Q000473:pathology*; D003213:Conditioning, Psychological; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013649:Taste