Pre- and postoperative auditory event-related potentials in temporal lobe epilepsy.
We studied auditory event-related potentials (ERPs) in 11 surgically treated patients with intractable temporal lobe epilepsy (TLE) pre- and postoperatively. ERPs through sphenoidal electrodes (Sp1-T3, Sp2-T4) provided clinically relevant and correctly lateralizing electrophysiologic evidence of temporal lobe dysfunction in 9 of 11 patients, confirmed by EEGs, electrocorticograms, neuroradiologic, and neuropsychological results, and clinical follow-up. Lateralizing asymmetries were noted in P300 amplitude, but latencies were prolonged bilaterally. Sphenoidal ERPs might serve as a new functional indicator of temporal lobe dysfunction in patients evaluated for epilepsy surgery.
Mervaala
E
E
Department of Clinical Neurophysiology, Vaajasalo Hospital, Kuopio, Finland.
Nousiainen
U
U
Kinnunen
J
J
Vapalahti
M
M
Riekkinen
P
P
D000293:Adolescent; D000328:Adult; D000679:Amygdala / Q000601:surgery; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery*; D005072:Evoked Potentials, Auditory; D005260:Female; D005500:Follow-Up Studies; D007839:Functional Laterality / Q000502:physiology; D006624:Hippocampus / Q000601:surgery; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011859:Radiography; D011930:Reaction Time / Q000502:physiology; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery*