Enhancement of hypoxia radioprotection and decrease of hypoxia toxicity caused by adenosine monophosphate.
It was shown in experiments on mice that the radioprotective effects of adenosine monophosphate (AMP) or of a combination of Mg aspartate and AMP join with those induced by hypobaric hypoxia. The hypotensive effects of these drugs lead probably to hypoxia in radiosensitive tissues which acts additively with hypoxia elicited by way of respiration. Furthermore, Mg aspartate and AMP decrease the toxicity of high degrees of hypobaric hypoxia. These effects can be explained by the ability of adenosine liberated from AMP and of magnesium to increase brain and heart blood perfusion and/or to mitigate excessive sympathetic activity. The pharmacological effects of AMP and Mg aspartate are thus not only radioprotective but also energy preserving and protecting vitally important organs against hypoxia toxicity. These effects may be of favourable importance in hypoxic radiotherapy.
Volenec
K
K
Medical Faculty, Charles University, Hradec Králové, Czechoslovakia.
Pospísil
M
M
Netíková
J
J
Pipalová
J
J
Kozubík
A
A
D000249:Adenosine Monophosphate / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D051379:Mice; D011837:Radiation-Protective Agents / Q000494:pharmacology*
D011837:Radiation-Protective Agents; D000249:Adenosine Monophosphate