[Evaluation of the effectiveness of serotonin (fluoxetine hydrochloride) treatment. Open study in fibromyalgia].
Primary fibromyalgia may involve an anomaly in the metabolism of serotonin responsible for the sleep disorders and diffuse pain. Effectiveness of an agent with pure serotonin-agonist properties (fluoxetin hydrochloride) was evaluated in 23 patients during a three-month open study. Treatment had no effect on pain severity, number of tender sites, or pain score. Sleep disorders improved and 57% of patients believed the treatment was effective. Adverse events were recorded in 43.4% of patients, with the most common being nausea (21.7%). Effectiveness and tolerance of fluoxetin hydrochloride in fibromyalgia are mediocre. A double-blind placebo-controlled trail versus a placebo is needed to clarify these preliminary findings.
Cortet
B
B
Service de Médecine Rhumatologique, Centre Hospitalier Saint-Philibert, Lomme-lès-Lille.
Houvenagel
E
E
Forzy
G
G
Vincent
G
G
Delcambre
B
B
D004341:Drug Evaluation; D005356:Fibromyalgia / Q000188:drug therapy*; D005473:Fluoxetine / Q000031:analogs & derivatives / Q000627:therapeutic use*; D006801:Humans
D005473:Fluoxetine
Evaluation de l'efficacité d'un traitement sérotoninergique (chlorhydrate de fluoxétine). Etude ouverte au cours de la fibromyalgie.