Changes in serum and urinary amino acids after the administration of a mixed beta-adrenergic agonist.
The administration of the repartitioning agent metaproterenol, with affinity for beta 1- and beta 2-receptors, induced marked increases in gastrocnemius muscle and heart weights. The renal loss of essential amino acids was reduced in animals treated with beta-adrenergic agonists and a significant reduction in total serum amino acids was found as well. The assessment of urinary 3-methylhistidine suggests, that those changes were accompanied by a lower myofibrillar protein breakdown, while hydroxyproline output was increased as an indirect index of collagen turnover.
Martínez
J A
JA
Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain.
Rguez-Mariscal
M
M
Del Barrio
A
A
Larralde
J
J
D000596:Amino Acids / Q000097:blood* / Q000652:urine*; D000818:Animals; D003404:Creatinine / Q000652:urine; D006321:Heart / Q000033:anatomy & histology; D006909:Hydroxyproline / Q000652:urine; D008297:Male; D009921:Metaproterenol / Q000494:pharmacology*; D008762:Methylhistidines / Q000652:urine; D009132:Muscles / Q000033:anatomy & histology / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D014508:Urea / Q000652:urine
D000596:Amino Acids; D008762:Methylhistidines; D009921:Metaproterenol; D014508:Urea; D003404:Creatinine; C028118:3-methylhistidine; D006909:Hydroxyproline