Synthesis and some central pharmacological properties of new 5(1H)oxo-2,3-dihydroimidazo[1,2-a]pyrimidine-6-carboxylic esters.
Six new 5(1H)oxo-2,3-dihydroimidazo[1,2-a]pyrimidine-6-carboxylic ethyl esters bearing an aromatic substituent in position 1 or 2 were obtained. Pharmacological studies on the central action of these derivatives were carried out on mice and rats. The highest activity showed compounds 1 and 2 which produced analgesic effects in mice.
Matosiuk
D
D
Department of Chemical Technology of Drugs, Medical Academy, Lublin, Poland.
Tkaczyński
T
T
Jagiełło-Wójtowicz
E
E
Wielosz
M
M
Szurska
G
G
Chodkowska
A
A
Janusz
W
W
Kleinrok
Z
Z
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
D011743:Pyrimidines