Post-irradiation protective effect of irsogladine maleate on intestinal crypt stem cells in mice.
Radioprotective effect of irsogladine maleate, an anti-ulcer drug, on the intestinal crypt stem cell survival was studied in mice using a crypt microcolony assay. Irsogladine maleate was injected intraperitoneally immediately after irradiation and then, daily for three days. A successive administration of the drug following 10 Gy of irradiation increased the survival of intestinal stem cells with a clear dose-related trend. In order to estimate the D0, survival curves were determined for X-ray plus placebo and X-ray plus 10 mg/kg of irsogladine maleate. The D0, for X-ray plus the drug was 2.2 Gy while it was 1.9 Gy for X-ray plus placebo. These findings suggest that isogladine maleate can be applied for the alleviation of intestinal damages in heavily irradiated people by radiation accidents.
Kurishita
A
A
Department of Radiation Research, Tohoku University School of Medicine, Sendai, Japan.
Takai
Y
Y
Ueda
F
F
Sakamoto
K
K
Ono
T
T
D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D007583:Jejunum / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000473:pathology; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D013047:Specific Pathogen-Free Organisms; D013234:Stem Cells / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects; D014227:Triazines / Q000627:therapeutic use*
D011837:Radiation-Protective Agents; D014227:Triazines; C041836:irsogladine