The role of the renal nerves in renin synthesis.
1. Renin synthesis and secretion were studied in Balb/c mice with a denervated left kidney. 2. Denervation inhibited renin secretion. 3. Denervation reduced the renal renin content. 4. Denervation reduced renal renin mRNA. 5. Renal denervation inhibits renin secretion by blocking the synthetic system prior to mRNA formation.
Zhang
Y
Y
Department of Physiology, University of Melbourne, Victoria, Australia.
Morgan
T
T
Read
G
G
D000818:Animals; D001345:Autoradiography; D003714:Denervation; D015151:Immunoblotting; D007668:Kidney / Q000294:innervation* / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012333:RNA, Messenger / Q000378:metabolism; D011863:Radioimmunoassay; D012044:Regression Analysis; D012077:Renal Artery / Q000737:chemistry; D012082:Renal Veins / Q000737:chemistry; D012083:Renin / Q000032:analysis / Q000096:biosynthesis* / Q000097:blood
D012333:RNA, Messenger; D012083:Renin