title: Water-in-oil emollients as steroid-sparing adjunctive therapy in the treatment of psoriasis.
abstract: An open label study of ninety-six patients with chronic plaque-type psoriasis demonstrated the efficacy of the addition of water-in-oil emollients to a topical corticosteroid regimen. Twice daily application of betamethasone dipropionate cream and once daily application of both betamethasone dipropionate cream and either a water-in-oil based moisturizing cream or lotion were equivalent in efficacy (p = 0.05). Once daily application of both betamethasone dipropionate cream and either a water-in-oil based cream or lotion was significantly better than once daily application of betamethasone dipropionate cream alone (p = 0.05). Water-in-oil emollients are useful in the therapy of chronic, plaque-type psoriasis and provide a steroid-sparing effect.
authors: Yale University School of Medicine, Department of Dermatology, New Haven, Connecticut 06519.
authors: K L
authors: KL
authors: Watsky
authors: L
authors: L
authors: Freije
authors: M C
authors: MC
authors: Leneveu
authors: H A
authors: HA
authors: Wenck
authors: D J
authors: DJ
authors: Leffell
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001623:Betamethasone / Q000008:administration & dosage*; D002908:Chronic Disease; D004643:Emollients / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009821:Oils; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology; D014867:Water
chemical_list: D004643:Emollients; D009821:Oils; D014867:Water; D001623:Betamethasone