Adenosine deaminase restores the ability of atrial natriuretic peptide to induce glomerular hyperfiltration in low-sodium rats.
Administration of a large dose of atrial natriuretic peptide is associated with an increase in glomerular filtration rate, diuresis and natriuresis in normal-sodium rats. However, glomerular hyperfiltration induced by atrial natriuretic peptide is markedly decreased in low-sodium rats. Glomerular insensitivity to atrial natriuretic peptide may be due to increased activity of the renin-angiotensin system in low-sodium rats and to an accompanying hypersensitivity to adenosine. The results indicate that attenuated glomerular responses to atrial natriuretic peptide are restored by the administration of adenosine deaminase in low-sodium rats. Moreover atrial natriuretic peptide markedly increases the urinary excretion of adenosine deaminase, which may be due to increased permeability of glomeruli to the enzyme.
Bizon
D
D
Department of Clinical Biochemistry, Medical Academy, Gdańsk, Poland.
Kalinowski
L
L
Angielski
S
S
D000243:Adenosine Deaminase / Q000494:pharmacology* / Q000652:urine; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D004039:Diet, Sodium-Restricted; D004305:Dose-Response Relationship, Drug; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D007262:Infusions, Intravenous; D007678:Kidney Glomerulus / Q000187:drug effects / Q000201:enzymology / Q000502:physiology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000494:pharmacology* / Q000652:urine; D014563:Urodynamics / Q000187:drug effects
D009320:Atrial Natriuretic Factor; D012964:Sodium; D000243:Adenosine Deaminase