Translocation t(12;22)(q13;q13) is a nonrandom rearrangement in clear cell sarcoma.
Cytogenetic analyses of tumor cells from a case of clear cell sarcoma revealed a translocation between chromosomes 12 and 22 that was similar to the rearrangement described recently in three other cases. It is suggested that the translocation may be important in the pathogenesis of this rare tumor.
Reeves
B R
BR
Section of Pathology, Institute of Cancer Research, Sutton, Surrey, United Kingdom.
Fletcher
C D
CD
Gusterson
B A
BA
D000293:Adolescent; D002881:Chromosomes, Human, Pair 12; D002892:Chromosomes, Human, Pair 22; D005260:Female; D006801:Humans; D007621:Karyotyping; D007866:Leg; D012509:Sarcoma / Q000235:genetics*; D012983:Soft Tissue Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic; D014407:Tumor Cells, Cultured