3-Methoxybutylcyanoacrylate: evaluation of biocompatibility and bioresorption.
The biocompatibility and bioresorption of 3-methoxybutylcyanoacrylate (MBCA) was evaluated in vivo using female Wistar albino rats. MBCA was found to elicit slight to moderate tissue reaction similar to isobutylcyanoacrylate (iBCA) which has been sold commercially as a surgical adhesive (Bucrylate, Ethicon). MBCA was judged less reactive to tissue than ethylcyanoacrylate (ECA). The MBCA implants in rat gluteal muscles also resorbed within approx. 16 wk while iBCA implants remained essentially unchanged at 36 wk in vivo. In vitro resorption in phosphate buffer (pH 7.2) at 37 degrees C showed the same trend. The MBCA performed similarly to iBCA as a haemostat on excised rat livers and as an adhesive on rat skin incisions and had comparable adhesive bond strength.
Henderson
A M
AM
Ethicon Ltd (a Johnson & Johnson Company), Peterborough, Ontario, Canada.
Stephenson
M
M
D000042:Absorption; D000818:Animals; D001672:Biocompatible Materials / Q000493:pharmacokinetics*; D002015:Bucrylate / Q000493:pharmacokinetics; D003487:Cyanoacrylates / Q000493:pharmacokinetics*; D004353:Drug Evaluation, Preclinical; D004659:Enbucrilate / Q000493:pharmacokinetics; D005260:Female; D006487:Hemostasis / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D008970:Molecular Weight; D011108:Polymers / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D014014:Tissue Adhesives / Q000493:pharmacokinetics*
D001672:Biocompatible Materials; D003487:Cyanoacrylates; D011108:Polymers; D014014:Tissue Adhesives; D002015:Bucrylate; C079573:3-methoxybutylcyanoacrylate; D004659:Enbucrilate