title: Effect of 50 kilobase-plasmid, pKDSC50, of Salmonella choleraesuis RF-1 strain on pig septicemia.
abstract: Salmonella choleraesuis strains with and without 50-kilobase plasmid (pKDSC50) were intravenously inoculated into Yorkshire pigs. By the inoculation of 7.2 x 10(5) - 3.5 x 10(7) cells, RF-1 strain with pKDSC50, but not 31N-1 strain without the plasmid, caused a septicemia. The inoculation of 8.7 x 10(9) RF-1 cells killed pigs at 2-4 day postinfection with severe hemorrhage on the whole body. Pigs with a similar number of 31N-1 cells (8.3 x 10(9) cells), showed milder hemorrhage, and they died at 6 day postinfection. These results indicated that pKDSC50 is required for RF-1 strain to express the full virulence causing a heavy cutaneous pig septicemia.
authors: Department of Bacteriology, Kitasato Institute, Tokyo, Japan.
authors: H
authors: H
authors: Danbara
authors: R
authors: R
authors: Moriguchi
authors: S
authors: S
authors: Suzuki
authors: Y
authors: Y
authors: Tamura
authors: M
authors: M
authors: Kijima
authors: K
authors: K
authors: Oishi
authors: H
authors: H
authors: Matsui
authors: A
authors: A
authors: Abe
authors: M
authors: M
authors: Nakamura
mesh_terms: D000818:Animals; D016470:Bacteremia / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D010957:Plasmids / Q000502:physiology*; D012475:Salmonella / Q000235:genetics / Q000472:pathogenicity*; D012481:Salmonella Infections, Animal / Q000382:microbiology* / Q000473:pathology; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology* / Q000473:pathology; D014774:Virulence / Q000235:genetics