title: Inactivation of the fis gene leads to reduced growth rate.
abstract: The FIS protein (factor for inversion stimulation) is known to activate the transcription of rRNA and tRNA operons in Escherichia coli. In this report the growth behaviour of a fis bacterium was studied under steady-state conditions and in competition experiments with a wild-type bacterium in a chemostat. The growth rate of the fis bacterium was reduced as compared to that of an isogenic wild-type and this reduction increased linearly with increasing growth rate. A similar result was obtained in competition experiments in a chemostat, with the selection factor increasing linearly with the growth rate.
authors: Department of Cell Biology, Arrhenius Laboratories, Stockholm University, Sweden.
authors: L
authors: L
authors: Nilsson
authors: H
authors: H
authors: Verbeek
authors: U
authors: U
authors: Hoffmann
authors: M
authors: M
authors: Haupt
authors: L
authors: L
authors: Bosch
mesh_terms: D002352:Carrier Proteins / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics / Q000254:growth & development*; D029968:Escherichia coli Proteins; D035021:Factor For Inversion Stimulation Protein; D015964:Gene Expression Regulation, Bacterial; D034982:Integration Host Factors; D009876:Operon
chemical_list: D002352:Carrier Proteins; D029968:Escherichia coli Proteins; D035021:Factor For Inversion Stimulation Protein; D034982:Integration Host Factors; C440502:integration host factor, E coli