[Drug induced cystitis due to ketotifen fumarate--a case report].
Tranilast, an antiallergic drug, is well known as a causal drug of cystitis, and a report is made here of our experience of 1 case of drug-induced cystitis ascribable to ketotifen fumarate. A 13-year-old female had been taking anti-asthmatic drugs orally since the onset of athmatoid attacks, from age of 5. The attacks intensified from the age of 12, because of this she began to take various anti-asthmatic drugs orally. She visited another hospital, due to pollakisuria, in November, 1990, and received treatment for cystitis. However, the symptoms were not alleviated, and she visited our department on January 9, 1991. By urinalysis, large counts of leukocytes and erythrocytes were observed in a visual field of the sediment. Remarkable reddening was observed over the urinary bladder in the patient's cystoscopic findings. Treatment was given at our department, on an outpatient basis, with various antibacterial drugs for approximately one month, but her symptoms were not alleviated, pollakisuria and aseptic pyuria persisted. The patient had never taken tranilast; oral intake of ketotifen fumarate and saibokutou was discontinued on February 13, due to a suspicion of drug-induced cystitis, and her symptoms subsequently disappeared. On February 22, she took ketotifen fumarate orally again, on her own, due to asthmatoid attack, and her symptoms returned. The oral intake of ketotifen fumarate was again discontinued, and alleviation of the symptoms and normalization of the urinary findings were again observed. As a result, lymphocyte stimulation tests on all the drugs the patient had ever taken, only ketotifen fumarate turned out to be positive.(ABSTRACT TRUNCATED AT 250 WORDS)
Hara
H
H
Department of Urology, Toho University School of Medicine.
Kurita
M
M
Morioka
H
H
Kuwabara
T
T
Kuroda
K
K
Matsuhashi
M
M
Ishii
N
N
Miura
K
K
Shirai
M
M
D000293:Adolescent; D001772:Blood Cell Count; D003556:Cystitis / Q000139:chemically induced* / Q000175:diagnosis; D003558:Cystoscopy; D005260:Female; D006801:Humans; D007665:Ketotifen / Q000009:adverse effects*; D008213:Lymphocyte Activation; D013224:Status Asthmaticus / Q000188:drug therapy; D001743:Urinary Bladder / Q000473:pathology
D007665:Ketotifen