Allocortical involvement in Huntington's disease.
Seven brains of individuals who had suffered from Huntington's disease and seven control brains were examined. Preparations stained for Nissl material and lipofuscin pigment revealed a characteristic layer-specific loss of nerve cells in two allocortical areas, the entorhinal region and the subiculum. The most severe changes occurred in the entorhinal layer Pri-gamma while layer Pre-alpha, layer Pre-gamma and the subiculum showed less severe alterations.
Braak
H
H
Department of Anatomy, J.W. Goethe University of Frankfurt, Germany.
Braak
E
E
D002470:Cell Survival; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D006816:Huntington Disease / Q000378:metabolism / Q000473:pathology*; D008032:Limbic System / Q000378:metabolism / Q000473:pathology; D008062:Lipofuscin / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000378:metabolism / Q000473:pathology
D008062:Lipofuscin