[Efficacy of pretreatment with adrenergic beta-receptor blockers in the prevention of cardiotoxic effects of isoprenaline in rats].
Protective effects of beta-blockers, propranolol and atenolol, have been investigated in rats treated with cardiotoxic dose of isoprenaline. In saline-pretreated animals isoprenaline produced all morphological, biochemical and electrophysiological signs of myocardial necrosis: massive coagulation necrosis of cardiomyocytes, 2.6 to 3.5-fold increase of creatine-kinase, lactate-dehydrogenase and alpha-hydroxybutyrate-dehydrogenase plasma activity and Q-wave and ST-segment elevation in ECG. Both beta-blockers protected only partly the rats heart muscle from the cardionecrogenic action of isoprenaline while propranolol has been slightly more efficient, probably due to its combined beta-blocking and antiperoxidative activity.
Ljubuncić
P
P
Institut za fiziologiju i biohemiju Dr Aleksandar Sabovljev, Medicinski fakultet, Sarajevo.
Stojiljković
M P
MP
Winterhalter-Jadrić
M
M
Vidović
Z
Z
Mujić
F
F
D000818:Animals; D001262:Atenolol / Q000494:pharmacology*; D004562:Electrocardiography / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D007545:Isoproterenol / Q000633:toxicity*; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D001262:Atenolol; D011433:Propranolol; D007545:Isoproterenol
Efikasnost predtretmana blokatorima beta-adrenergickih receptora u suzbijanju kardiotoksicnih efekata izoprenalina u pacova.