title: Screening for microalbuminuria. A comparison of single sample methods of collection and techniques of albumin analysis.
abstract: OBJECTIVE
  To evaluate single-sample urine collections to determine their ability to screen patients for the presence of microalbuminuria. Microalbuminuria in patients with type I diabetes predicts the development of diabetic renal disease.
  
  
  METHODS
  Cross-sectional analysis of single-sample urine collection techniques (first morning void, random upright void) and methods of albumin analysis (RIA, reagent tablet) were compared with conventional 24-h urine collections (RIA). The study included 94 patients (45 males, 49 females; mean serum creatinine 88 microM) with type I diabetes, selected from a screened population of 301 patients from the University Hospital Subspecialty Clinics.
  
  
  RESULTS
  A 24-hour urine collection RIA analysis for albumin revealed 36 normal patients (< 30 mg), 27 with microalbuminuria (30-300 mg), and 31 with albuminuria (> 300 mg). Random upright urine samples were more sensitive (RIA 89%, tablets 78%) for the detection of microalbuminuria than first morning void specimens (RIA 70%, tablets 60%). Specificity was > 80% with both random and first morning voids.
  
  
  CONCLUSIONS
  Screening for microalbuminuria can be performed in the clinic by random upright single-sample urine collections. When reagent tablets were used, these results are available immediately. Patients who screen positive should be confirmed by 24-h or other timed urine collections.
authors: Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
authors: S J
authors: SJ
authors: Schwab
authors: F L
authors: FL
authors: Dunn
authors: M N
authors: MN
authors: Feinglos
mesh_terms: D000328:Adult; D000419:Albuminuria; D003922:Diabetes Mellitus, Type 1 / Q000652:urine*; D003928:Diabetic Nephropathies / Q000175:diagnosis / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening; D011863:Radioimmunoassay / Q000379:methods; D011933:Reagent Kits, Diagnostic; D012016:Reference Values; D012709:Serum Albumin / Q000032:analysis*
chemical_list: D011933:Reagent Kits, Diagnostic; D012709:Serum Albumin