Fluorenone and benzophenone 1,4-dihydropyridine derivatives with cardiodepressant activity.
A series of fluorenone and benzophenone 1,4-dihydropyridine derivatives were prepared. The compounds were evaluated for inotropic, chronotropic and calcium antagonist properties.
Rampa
A
A
Budriesi
R
R
Bisi
A
A
Chiarini
A
A
Valenti
P
P
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001577:Benzophenones / Q000138:chemical synthesis* / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000138:chemical synthesis / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D005449:Fluorenes / Q000138:chemical synthesis* / Q000494:pharmacology; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects
D000889:Anti-Arrhythmia Agents; D001577:Benzophenones; D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D005449:Fluorenes