[Activity of menadione reductase and level of cytochrome B5 and P-450 in liver with varying supplies of vitamin K and administration of pelentan to rats].
Content of cytochromes b5 and P-450 as well as activity of soluble menadione reductase were estimated in liver microsomes of rats deprived of vitamin K or maintained both on a diet containing excess of vicasol or antivitamin K-pelentan. Deficiency of vitamin K led to an increase in the specific activity of menadione reductase and in content of the cytochrome P-450. Administration of antivitamin K did not alter these parameters but caused an increase in the content of cytochrome b5, which was not changed in vitamin K deficiency. Dissimilar effects of alimentary deficiency in vitamin K and of pelentan administration suggest that administration of antivitamins K (although it allowed to discover alterations developed via the system of vitamin K-dependent carboxylation) could not be completely identified with alimentary vitamin K deficiency.
Sokol'nikov
A A
AA
Shinkevich
T E
TE
Kodentsova
V N
VN
Vrzhesinskaia
O A
OA
Spirichev
V B
VB
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D015786:Cytochromes b5 / Q000378:metabolism*; D005017:Ethyl Biscoumacetate / Q000008:administration & dosage*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014813:Vitamin K Deficiency / Q000201:enzymology*
D005017:Ethyl Biscoumacetate; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D016660:NAD(P)H Dehydrogenase (Quinone)
Aktivnost' menadionreduktazy i soderzhanie tsitokhormov B5 i P-450 v pecheni pri razlichnoĭ obespechennosti krys vitaminom K i vvedenii pelentana.