title: Correlation of nocturnal increase in plasma oxytocin with a decrease in plasma estradiol/progesterone ratio in late pregnancy.
abstract: OBJECTIVE
  Our purpose was to determine whether plasma oxytocin concentrations show a daily rhythm.
  
  
  METHODS
  Ten women between 37 and 39 weeks of gestation volunteered for the study. They were admitted 1 to 2 days before the experiment. Three blood samples were taken with 2-minute intervals each time, at 8 AM, 4 PM, and 12 midnight. Oxytocin, 17 beta-estradiol, progesterone, and cortisol were measured by radioimmunoassay with highly specific antibodies. Statistical analysis of variance by Friedman's test was followed by multiple range testing, and p < 0.05 was considered significant.
  
  
  RESULTS
  Significant daily rhythm was found for plasma cortisol, progesterone, and oxytocin and for the estradiol/progesterone ratio. Oxytocin showed a nocturnal peak and a strong negative correlation with the estradiol/progesterone ratio.
  
  
  CONCLUSIONS
  The daily rhythm in plasma oxytocin parallels the rhythm in uterine activity (shown by others), suggesting a causal relationship between the two. Both may in turn be related to the ratio of circulating estradiol and progesterone.
authors: Department of Obstetrics and Gynecology, Cornell University Medical College, New York, NY 10021.
authors: A R
authors: AR
authors: Fuchs
authors: O
authors: O
authors: Behrens
authors: H C
authors: HC
authors: Liu
mesh_terms: D002940:Circadian Rhythm; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D009994:Osmolar Concentration; D010121:Oxytocin / Q000097:blood*; D011247:Pregnancy / Q000097:blood*; D011263:Pregnancy Trimester, Third; D011374:Progesterone / Q000097:blood*
chemical_list: D011374:Progesterone; D004958:Estradiol; D010121:Oxytocin