title: Anion transport by human placenta: a study of chloride and sulphate efflux from isolated placental tissue fragments.
abstract: The efflux of radiolabelled sulphate and chloride from fragments prepared from normal human term placentae has been examined so that a comparison between the transport properties of whole tissue and isolated placental membranes may be made. Sulphate efflux was found via a temperature- and DIDS sensitive mechanism. External chloride and sulphate were able to trans-accelerate the egress of labelled sulphate from tissue fragments via a DIDS-inhibitable route. These results are consistent with sulphate transport being mediated via an anion-exchange process. Chloride efflux from fragments of placenta was via a system which could be trans-stimulated by external Cl-: this moiety of transport was inhibited by DIDS. Several differences between the characteristics of placental tissue anion transport and isolated membrane vesicles were noted and are discussed.
authors: Hannah Research Institute, Scotland, UK.
authors: D B
authors: DB
authors: Shennan
mesh_terms: D001692:Biological Transport / Q000502:physiology; D002712:Chlorides / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007231:Infant, Newborn; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D013431:Sulfates / Q000493:pharmacokinetics*
chemical_list: D002712:Chlorides; D013431:Sulfates