Isolation of a bradykinin-potentiating factor from scorpion Tityus serrulatus venom.
A bradykinin-potentiating factor was isolated and characterized from the scorpion Tityus serrulatus venom by chromatographic techniques and reverse phase followed by biological assays. This factor showed to be able to potentiate the contractile activity of the isolated guinea-pig ileum, inhibited the angiotensin-converting enzyme and potentiated the bradykinin-induced lowering of the arterial blood pressure in the rat.
Ferreira
L A
LA
Department of Biochemistry, Butantan Institute, Sao Paulo, Brasil.
Henriques
O B
OB
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001920:Bradykinin / Q000378:metabolism* / Q000494:pharmacology; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D009842:Oligopeptides / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats; D012604:Scorpion Venoms / Q000737:chemistry*
D000806:Angiotensin-Converting Enzyme Inhibitors; D009842:Oligopeptides; D012604:Scorpion Venoms; C006791:bradykinin potentiating factors; D001920:Bradykinin