title: [Surgical versus non-surgical treatment in patients with esophageal varices--a prospective randomized study].
abstract: In Japan, non-shunting procedures and selective shunt such as esophageal transection (ET), and distal splenorenal shunt (DSRS) have been widely performed. A prospective randomized trial was done to assess the effects of EIS and DSRS for treating patients with esophageal varices. Ninety-six Japanese with good liver function (Child A or B) and large esophageal varices were randomly assigned to one of three groups given different treatments; (EIS, n = 32), (ET, n = 32) and (DSRS, n = 32). Five patients (15.6%) of the DSRS group has to be excluded from this study, because of severe chronic pancreatitis. No patient died within 30 days of the treatments. The 5-year cumulative bleeding rates were 0%, 4.3% and 12.1% in the EIS, ET and DSRS groups, respectively, with no statistical significances. In no case in the three groups did the death occur because of variceal bleeding. Nineteen patients died mainly due to the underlying liver disease; 5 in the EIS, 5 in the ET and 9 in the DSRS group. There was no statistically significant difference in the survival rates among the three groups. We conclude that EIS is a satisfactory alternative to ET or DSRS for the management of patients with large esophageal varices.
authors: Department of Surgery II, Kyushu University, Faculty of Medicine, Fukuoka, Japan.
authors: S
authors: S
authors: Kitano
authors: M
authors: M
authors: Ohta
authors: K
authors: K
authors: Ueno
authors: M
authors: M
authors: Hashizume
authors: Y
authors: Y
authors: Iso
authors: N
authors: N
authors: Koyanagi
authors: K
authors: K
authors: Sugimachi
mesh_terms: D000328:Adult; D004932:Esophageal and Gastric Varices / Q000401:mortality / Q000601:surgery / Q000628:therapy*; D016629:Esophagectomy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D015911:Sclerotherapy; D013164:Splenorenal Shunt, Surgical; D015996:Survival Rate