Ascites in broilers. 2. Disturbances in the hormonal regulation of metabolic rate and fat metabolism.
Effects of different broiler stocks, ambient temperatures (Ta), dietary energy content (AME), and dietary levels of unsaturated fat on plasma thyroid and growth hormone concentrations and energy metabolism were studied. An experiment with a 2 x 2 x 2 x 2 factorial split-plot arrangement of treatments with 96 groups of 12 male broilers each was performed. Blood samples were taken at 3, 4, and 5 wk of age. Energy metabolism parameters were determined over an entire period from 1 to 5 wk of age. Chickens from a line selected for fast growth rate and low feed conversion ratio but also more sensitive to heart failure syndrome (HFS) and ascites (Line SS) than commercial birds (Line BC) exhibited the greatest responses to experimental factors. Differences in levels of plasma thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3), and growth hormone (GH) between stocks at different ages were highly dependent on Ta and dietary fat content. Differences in heat production per metabolic weight, percentage of retained fat energy in retained energy, and efficiency of AME intake for retained energy between stocks corresponded to differences in hormone levels. High-fat diets (polyunsaturated fatty acids) inhibited the extra thyroidal conversion of T4 to T3 in both stocks. Differences between stocks in T3 and rT3 levels in plasma indicated that BC birds (in contrast to SS birds) were better able to compensate for an inhibited T4 conversion to T3 by producing more T4. Overall results suggest that the occurrence of HFS and ascites in SS birds could be initiated independently by different factors. These factors might be a limited thyroid hormone production and a lower capacity for oxygen consumption. An inverse relationship between T3 and GH levels found in particular combinations of experimental factors, together with changes in fat deposition, support published concepts about the positive effects of T3 on lipogenesis and GH on lipolysis.
Scheele
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CW
Spelderholt Centre for Poultry Research and Information Services, Beekbergen, The Netherlands.
Decuypere
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E
Vereijken
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PF
Schreurs
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FJ
D000375:Aging / Q000378:metabolism; D000818:Animals; D001201:Ascites / Q000378:metabolism / Q000662:veterinary*; D002645:Chickens / Q000378:metabolism*; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology*; D002149:Energy Intake; D004734:Energy Metabolism; D013006:Growth Hormone / Q000097:blood*; D008297:Male; D011201:Poultry Diseases / Q000378:metabolism*; D013696:Temperature; D013963:Thyroid Hormones / Q000097:blood*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014285:Triiodothyronine, Reverse / Q000097:blood
D004041:Dietary Fats; D013963:Thyroid Hormones; D014284:Triiodothyronine; D014285:Triiodothyronine, Reverse; D013006:Growth Hormone; D013974:Thyroxine