[The effect of nitroxyl radicals and sodium nitrite on the methemoglobin content of the blood and on the enzymatic activity of erythrocyte antioxidant protection].
Preliminary introduction of nitroxyl radicals to mice decreases methaemoglobin-forming effect of sodium nitrite and diminishes the content of total SH-groups and restored glutathione as well as the activity of glutathione reductase and total activity of dehydrogenases of the pentosophosphate path of erythrocytes. High level of lipids peroxidation in case of sodium nitrite intoxication remains unchanged under preliminary administration of nitroxyl radicals as well. Activity of the key enzymes of antioxidant protection of erythrocytes, superoxide dismutase and catalase, is not recovered with sodium nitrite intoxication in presence of nitroxyl radicals.
Shugaleĭ
I V
IV
Tselinskiĭ
I V
IV
Kashparova
V P
VP
Kashparov
I S
IS
D000818:Animals; D000975:Antioxidants; D004912:Erythrocytes / Q000187:drug effects* / Q000201:enzymology; D005609:Free Radicals / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008706:Methemoglobin / Q000032:analysis / Q000187:drug effects*; D051379:Mice; D009589:Nitrogen Oxides / Q000494:pharmacology*; D010084:Oxidation-Reduction / Q000187:drug effects; D010108:Oxyhemoglobins / Q000032:analysis / Q000187:drug effects; D012977:Sodium Nitrite / Q000494:pharmacology* / Q000506:poisoning; D013329:Structure-Activity Relationship
D000975:Antioxidants; D005609:Free Radicals; D009589:Nitrogen Oxides; D010108:Oxyhemoglobins; D008706:Methemoglobin; C039900:nitroxyl; D012977:Sodium Nitrite
Vliianie nitroksil'nykh radikalov i nitrita natriia na soderzhanie metgemoglobina v krovi i aktivnost' fermentov antioksidantnoĭ zashchity éritrotsitov.