Enhanced gastric acid secretion induced by gastrin can be suppressed partially by glucose injection into the medullary nuclei in rats.
Gastric acid outputs after glucose injection into the nucleus of the vagus nerve (X) or into the nucleus of the tractus solitarius (SOL) were examined in rats with tetragastrin. The enhanced acid output caused by gastrin was partially inhibited by glucose injection into the X or SOL. Glucose injection into the X depressed acid output in a dose-dependent fashion, but a non-dose-dependent response in acid output was seen when glucose was injected into the SOL. There was no interaction between the X and SOL in acid response due to glucose. These findings suggest that glucose modulates gastric acid secretion stimulated by gastrin at the medullary level, and that such a modulation is characterized by the medullary X or SOL, separately.
Sakaguchi
T
T
Department of Physiology, Niigata University School of Medicine, Japan.
Aono
T
T
Ohtake
M
M
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology*; D007267:Injections; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology*; D009994:Osmolar Concentration; D051381:Rats; D017208:Rats, Wistar; D013758:Tetragastrin / Q000494:pharmacology; D014630:Vagus Nerve / Q000502:physiology
D005755:Gastrins; D013758:Tetragastrin; D005947:Glucose