title: Dose-response effects of oral loxiglumide on postprandial gall-bladder emptying in man.
abstract: The effect of two different single oral doses of loxiglumide (CR 1505, CAS 107097-80-3) on gall-bladder emptying induced by a 550-cal standard mixed meal in 6 healthy volunteers was studied. Following placebo, the maximal gall-bladder emptying occurred about 90 min after the meal (minimal residual gall-bladder volume 27.4% of basal volume). Loxiglumide 400 or 800 mg dose-dependently inhibited the physiologica gall-bladder emptying. Loxiglumide plasma levels dose-dependently increased. The inhibition of gall-bladder emptying and the kinetic of loxiglumide plasma levels were temporally related. The results of the present study confirm that oral loxiglumide is a potent orally active cholecystokinin (CCK) antagonist in man and that CCK is the major physiological mediator of gallbladder emptying in response to meal.
authors: Istituto di Medicina Interna, Università di Milano, Italy.
authors: A
authors: A
authors: Malesci
authors: C
authors: C
authors: De Fazio
authors: S
authors: S
authors: Festorazzi
authors: C
authors: C
authors: Bonato
authors: A
authors: A
authors: Valentini
authors: M
authors: M
authors: Tacconi
authors: M
authors: M
authors: Bekkering
authors: G
authors: G
authors: Giacovelli
authors: M
authors: M
authors: D'Amato
authors: L C
authors: LC
authors: Rovati
mesh_terms: D000328:Adult; D002766:Cholecystokinin / Q000037:antagonists & inhibitors*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005502:Food; D005704:Gallbladder / Q000033:anatomy & histology; D016473:Gallbladder Emptying / Q000187:drug effects*; D006801:Humans; D008297:Male; D011377:Proglumide / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: C053737:loxiglumide; D002766:Cholecystokinin; D011377:Proglumide