Wegener's granulomatosis with papillary adenocarcinoma of the thyroid.
A 59-year-old woman was admitted with scleritis, sinusitis, skin eruptions, nodular lesions of both lung fields in chest X-ray films and renal failure. Skin biopsy and elevation of the titer of anti-neutrophil cytoplasmic antibody confirmed Wegener's granulomatosis. A right nodular goiter was palpated and a diagnosis of thyroid cancer was made based on aspiration cytology. Although combined therapy with cyclophosphamide and corticosteroid was started and the Wegener's granulomatosis improved and disappeared except for the renal lesion, the renal failure worsened and she died. Apparently only 2 cases of Wegener's granulomatosis complicated with carcinoma as in this case have been reported.
Araki
R
R
Third Department of Internal Medicine, Mie University School of Medicine, Japan.
Shima
T
T
Goto
H
H
Imoto
I
I
Baba
M
M
Misaki
M
M
Suzuki
S
S
D000231:Adenocarcinoma, Papillary / Q000150:complications* / Q000175:diagnosis; D001706:Biopsy; D001853:Bone Marrow / Q000187:drug effects; D003520:Cyclophosphamide / Q000009:adverse effects / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D011859:Radiography; D012867:Skin / Q000473:pathology; D013964:Thyroid Neoplasms / Q000150:complications* / Q000175:diagnosis
D003520:Cyclophosphamide; D011239:Prednisolone