[Antiperinuclear antibodies and corrisponding antigens].
Antiperinuclear factors (APF) are directed to epithelial cell "kerato-hyaline granules". Standardization of the APF test has been achieved, but the way to express the results is still debatable. APF were found to be present in 76% of rheumatoid arthritis (RA) patients: thus the sensitivity and the specificity for RA were 76 and 97%, respectively. No clinical or serological associations were substantiated in RA. The antigens targetted by these auto-antibodies are extremely variable from one to another donor.
Youinou
P
P
Laboratoire d'Immunologie, CHU, Brest.
Berthelot
J M
JM
Péron
A
A
Leroux
A M
AM
Le Goff
P
P
D000974:Antibodies, Antinuclear / Q000032:analysis* / Q000302:isolation & purification; D000940:Antigenic Variation; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006801:Humans
D000974:Antibodies, Antinuclear; C030902:antiperinuclear factor
Anticorps anti-périnucléaires et antigènes correspondants.