[The use of monolaurates for removing endotoxins from preparations of cell-free pertussis vaccine].
The possibility of using monolaurates for removing endotoxin from acellular pertussis vaccines developed at the Laboratory of Immunomodulators, Mechnikov Research Institute for Vaccines and Sera (Moscow), has been studied. Monolaurates PEG-400 and PEG-600 obtained, respectively, from Fluka Chemie AG and Ferak GmbH (Germany) have been used. The use of monolaurate PEG-600 ensures the decrease of the toxicity of acellular pertussis vaccines by 2.34-6.3 times.
Perel'man
E V
EV
Bulk
V F
VF
Remova
T N
TN
Bazhanova
I G
IG
Ozeretskovskaia
M N
MN
Zakharova
N S
NS
D000818:Animals; D004353:Drug Evaluation, Preclinical; D007202:Indicators and Reagents; D007848:Laurates; D008722:Methods; D051379:Mice; D010567:Pertussis Vaccine / Q000276:immunology / Q000302:isolation & purification* / Q000633:toxicity; D011092:Polyethylene Glycols; D010566:Virulence Factors, Bordetella / Q000302:isolation & purification* / Q000633:toxicity
D007202:Indicators and Reagents; D007848:Laurates; D010567:Pertussis Vaccine; D010566:Virulence Factors, Bordetella; D011092:Polyethylene Glycols
Ispol'zovanie monolauratov dlia udaleniia éndotoksinov iz preparatov beskletochnoĭ kokliushnoĭ vaktsiny.