Characterization of the gene encoding human pituitary-specific transcription factor, Pit-1.
Pit-1 is a pituitary-specific transcription factor that binds to and transactivates promoters of growth hormone- and prolactin-encoding genes. A chromosomal gene related to human Pit-1 isolated from human gene libraries was over 14 kb long and split into six exons. All of the splice donor and acceptor sites conformed to the GT/AG rule. The gene was mapped to human chromosome region 3p11.
Ohta
K
K
Department of Pediatrics, Kumamoto University School of Medicine, Japan.
Nobukuni
Y
Y
Mitsubuchi
H
H
Ohta
T
T
Tohma
T
T
Jinno
Y
Y
Endo
F
F
Matsuda
I
I
D001483:Base Sequence; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D004247:DNA; D004268:DNA-Binding Proteins / Q000235:genetics*; D005091:Exons; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008969:Molecular Sequence Data; D050817:Transcription Factor Pit-1; D014157:Transcription Factors / Q000235:genetics*
D004268:DNA-Binding Proteins; C494187:POU1F1 protein, human; D050817:Transcription Factor Pit-1; D014157:Transcription Factors; D004247:DNA