The neuropeptide, neuromedin C, activates a potassium current in mouse macrophages.
Neuromedin C (NmC) induced an outward current (Io(NmC)) in macrophages. Reversal potentials were dependent on external K+ concentrations ([K+]o) and independent of [Cl-]o. Tetraethylammonium (TEA) and quinidine effectively suppressed Io(NmC). Charybdotoxin (ChTX) and apamin had little effect. Io(NmC) was abolished in Ca(2+)-free EGTA-containing solution. These results suggest that MnC activates a Ca(2+)-dependent K+ current (IK,Ca) and can modulate activities in macrophages.
Ichinose
M
M
Department of Physiology, Shimane Medical University, Izumo, Japan.
Hara
N
N
Sawada
M
M
Maeno
T
T
D000595:Amino Acid Sequence; D000818:Animals; D001839:Bombesin / Q000502:physiology*; D008264:Macrophages / Q000378:metabolism* / Q000502:physiology; D008564:Membrane Potentials; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000502:physiology*; D011188:Potassium / Q000378:metabolism; D015221:Potassium Channels / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid
D010446:Peptide Fragments; D015221:Potassium Channels; C040794:neuromedin C; D001839:Bombesin; D011188:Potassium