title: Amiloride impairs the cholinergic regulation of potassium permeability in the human sweat gland but not in the rat submandibular gland.
abstract: Potassium permeability was monitored in human sweat glands and rat submandibular glands. Acetylcholine increased permeability in both tissues and the responses consisted of transient, calcium-independent and sustained, calcium-dependent components. Amiloride, a drug which inhibits Na(+)-H+ countertransport, impaired the regulation of potassium permeability in sweat glands but not in the submandibular gland. It is suggested that the stimulus-permeability coupling process in the sweat gland may be sensitive to the lowering of internal pH.
authors: Institute of Physiology, University of Glasgow, Scotland.
authors: S M
authors: SM
authors: Wilson
authors: J D
authors: JD
authors: Pediani
authors: D M
authors: DM
authors: Jenkinson
authors: H Y
authors: HY
authors: Elder
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology*; D000584:Amiloride / Q000494:pharmacology*; D000818:Animals; D006801:Humans; D010539:Permeability; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D013363:Submandibular Gland / Q000378:metabolism*; D013545:Sweat Glands / Q000378:metabolism*
chemical_list: D000584:Amiloride; D000109:Acetylcholine; D011188:Potassium