The formation and crystal structure of dihydronitidine and discussion of anticancer mechanism of nitidine cation.
The paper reports the formation and crystal structure of dihydronitidine, expounds the reasons and conditions of easily formed oxynitidine, and discusses anticancer mechanism of nitidine (cation). The crystallographic parameters of dihydronitidine are: space group P(2)1/n, a = 12.54(1), b = 9.148(5), c = 14.748(8) A, beta = 92.12(6)degrees, Z = 4. 4108 independent reflections were collected within the range of 3 degrees < or = 2 theta < or = 54 degrees, of which 2137 intensity data with I > or = 3 sigma (I) were used in the structural determination. The crystal structure has been refined by full matrix least-square method to a final R of 0.050.
Chen
Y Z
YZ
Fujian Institute of Research on the Structure of Matter, Academia Sinica, Fuzhou, PRC.
Tang
G Y
GY
Xu
B J
BJ
Wu
Q J
QJ
Lu
C Z
CZ
Li
J Q
JQ
Huang
Z X
ZX
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry; D053119:Benzophenanthridines; D003461:Crystallography; D015394:Molecular Structure; D010617:Phenanthridines / Q000138:chemical synthesis* / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D053119:Benzophenanthridines; D010617:Phenanthridines; C079105:dihydronitidine