[Tumor-biologic and epidemiologic aspects of laryngeal cancers in women before and after menopause].
44 women with laryngeal cancer were treated between 1961 and 1991 in the ENT clinic of the university of Rostock. 7 patients were found in the phase of fertility, 12 patients within the climacteric and 25 patients in the senium. Half of the patients before menopause and 2/3 of the patients after menopause were smokers. Only one of the women at the fertile age had a laryngological history lasting 1 year before the onset of the cancer illness but half of the patients after menopause revealed such an anamnesis. Laryngological symptoms that existed over a period of one year or more began before the onset of the climacteric phase or clearly in the senium phase. These points in time corresponded to phases of relative or absolute decrease of oestrogens from an endocrinological view. The mean controlled survival time of the patients decreased clearly with increasing age. Furthermore, in the case of the patients with over one year's laryngeal anamnesis the survival time was longer than for patients without anamnesis, at least for patients in the phase of the senium. Several parameters of tumour biology, tumour dynamics and gynaecological history were examined by the authors. A trend indicating an increase of glottic localisation after the onset of the climacteric phase and increase of keratinised carcinomas in the phase of senium was apparent. No other clear differences amongst the patients of various groups could be observed.
Kleemann
D
D
Klinik und Poliklinik für Hals-Nasen-Ohren-Krankheiten Otto Körner, Medizinische Fakultät, Universität Rostock.
Töwe
R
R
Kramp
B
B
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D003430:Cross-Sectional Studies; D005260:Female; D005858:Germany / Q000453:epidemiology; D012739:Gonadal Steroid Hormones / Q000502:physiology*; D006801:Humans; D015994:Incidence; D007822:Laryngeal Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D007830:Larynx / Q000473:pathology; D008593:Menopause / Q000502:physiology*; D008875:Middle Aged; D009367:Neoplasm Staging; D010212:Papilloma / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D011230:Precancerous Conditions / Q000453:epidemiology / Q000209:etiology / Q000473:pathology
D012739:Gonadal Steroid Hormones
Tumorbiologische und epidemiologische Aspekte der Larynxkarzinome bei Frauen vor und nach der Menopause.