Ouabain--a link in the genesis of high blood pressure?
Hypertension or high blood pressure is a risk factor that increases risk of myocardial infarction, renal failure or cerebral stroke. The pathogenesis of hypertension is due to a variety of causes, including inherited predisposition, dietary habits, especially salt intake, smoking, and also 'general lifestyle'. But for the scientist interested in the complex interplay of physiological and molecular factors, the actual causes of high blood pressure remain uninvestigated. The following article is concerned with new reports that ouabain, a plant derivative, occurs in human beings, in whom it appears to have a hormonal function; ouabain may even play a key role in the pathogenesis of hypertension. We are thus brought a step closer to the background of cardiovascular disease; we may also be afforded a lead to a new therapeutic principle.
Rüegg
U T
UT
Ecole de Pharmacie, Université de Lausanne, Switzerland.
D002301:Cardiac Glycosides / Q000494:pharmacology; D006973:Hypertension / Q000209:etiology*; D007668:Kidney / Q000187:drug effects; D009130:Muscle, Smooth; D045283:Natriuretic Agents / Q000737:chemistry; D010042:Ouabain / Q000494:pharmacology*
D002301:Cardiac Glycosides; D045283:Natriuretic Agents; D010042:Ouabain