Effects of phenylalaninol on centrally induced gastric acid secretion.
The effects of phenylalaninol (D-isomer) on gastric acid secretion and gastric ulcer were studied in rats. The compound reduced the gastric acid secretion stimulated by intracisternal thyrotropin releasing hormone and intravenous 2-deoxy-D-glucose, but not that stimulated by subcutaneous carbachol or histamine. Phenylalaninol prevented stress- and indomethacin-induced gastric ulcers. We conclude that phenylalaninol inhibits ulcer formation mainly by central inhibition of gastric acid secretion.
Hashizume
H
H
Fuji Chemical Industries, Ltd., Toyama, Japan.
Miyamae
T
T
Morikawa
T
T
Hagiwara
M
M
D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D003847:Deoxyglucose / Q000494:pharmacology; D005744:Gastric Acid / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D008297:Male; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000517:prevention & control*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
C012481:phenylalaninol; D010649:Phenylalanine; D013973:Thyrotropin-Releasing Hormone; D006632:Histamine; D002217:Carbachol; D003847:Deoxyglucose