[Effects of cortisol on calcium contents of lymphocytes in patients with bronchial asthma].
A fluorescent probe was used to study hydrocortisone (10 microM) action on mitogen-stimulated free cytoplasmic calcium level in lymphocytes of patients with bronchial asthma. The patients were divided into two groups according to their sensitivity to glucocorticoid therapy. Hydrocortisone-specific calcium-blocking effect was absent in hormone-resistant patients. Lymphocytes of hormone-sensitive patients responded to hydrocortisone administration by a decline of mitogen-induced calcium level.
Dukhanin
A S
AS
Bulaeva
N N
NN
D000328:Adult; D001249:Asthma / Q000097:blood / Q000188:drug therapy*; D002118:Calcium / Q000097:blood*; D003593:Cytoplasm / Q000737:chemistry; D005453:Fluorescence; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology* / Q000627:therapeutic use; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000737:chemistry* / Q000187:drug effects; D008875:Middle Aged
D002118:Calcium; D006854:Hydrocortisone
Vliianie kortizola na soderzhanie kal'tsiia v limfotsitakh bol'nykh bronkhial'noĭ astmoĭ.