title: Diagnosis of measles by clinical case definition in dengue-endemic areas: implications for measles surveillance and control.
abstract: In many countries, measles surveillance relies heavily on the use of a standard clinical case definition; however, the clinical signs and symptoms of measles are similar to those of dengue. For example, during 1985, in Puerto Rico, 22 (23%) of 94 cases of illnesses with rashes that met the measles clinical case definition were serologically confirmed as measles, but 32 (34%) others were serologically confirmed as dengue. Retrospective analysis at the San Juan Laboratories of the Centers for Disease Control showed also that at least 28% of all laboratory-confirmed cases of dengue in Puerto Rico in 1985 met the measles clinical case definition. If the true measles vaccine efficacy (VE) is assumed to be 90%, the occurrence of laboratory-confirmed dengue cases that meet the measles clinical case definition results in a reduction of the apparent measles VE to only 64% (a 29% relative reduction from the true VE). The results of the study demonstrate the importance of a laboratory-based surveillance system in measles control or elimination efforts in dengue-endemic areas.
authors: Epidemiology Program Office, Centers for Disease Control, Atlanta, GA 30333.
authors: V J
authors: VJ
authors: Dietz
authors: P
authors: P
authors: Nieburg
authors: D J
authors: DJ
authors: Gubler
authors: I
authors: I
authors: Gomez
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003715:Dengue / Q000175:diagnosis*; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D004812:Epidemiologic Methods; D006801:Humans; D007223:Infant; D008457:Measles / Q000175:diagnosis* / Q000453:epidemiology / Q000517:prevention & control; D011647:Puerto Rico / Q000453:epidemiology