[Experimental atherosclerosis and its correction with Co-35].
Initial and Co-35-induced parameters of lipid metabolism and hemostasis were studied in rabbits with experimental atherosclerosis. Control atherosclerotic animals were administered cobalt chloride and placebo. The findings demonstrated initially increased levels of cholesterol, lecithin, beta-lipoproteins, lysolecithin, sphingomyelin, cephalin, saturated acids in low levels of phosphatidylserine, polyglycerophosphatide and unsaturated acids. Hemostasis was characterized by hypercoagulation. A course of Co-35 brought about positive shifts in both lipid metabolism and hemostasis. Co-35 is recommended as an effective means against atherosclerosis.
Dzhuraev
Kh N
KhN
Nasriddinova
N N
NN
D000818:Animals; D001161:Arteriosclerosis / Q000097:blood / Q000188:drug therapy*; D002784:Cholesterol / Q000097:blood; D003035:Cobalt / Q000627:therapeutic use*; D005227:Fatty Acids / Q000097:blood; D006487:Hemostasis; D008077:Lipoproteins, LDL / Q000097:blood; D008244:Lysophosphatidylcholines / Q000097:blood; D010713:Phosphatidylcholines / Q000097:blood; D010714:Phosphatidylethanolamines / Q000097:blood; D011817:Rabbits; D013109:Sphingomyelins / Q000097:blood
D005227:Fatty Acids; D008077:Lipoproteins, LDL; D008244:Lysophosphatidylcholines; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D013109:Sphingomyelins; D003035:Cobalt; D002784:Cholesterol; C018021:cobaltous chloride
Eksperimental'nyĭ ateroskleroz i ego korrektsii Co-35.