[Morphologic features of the liver in sarcoidosis].
Granulomatous hepatitis with non-caseous epithelioid-cell granulomas (43 cases, 86%) and non-specific reactive hepatitis (7 cases, 14%) were observed in liver biopsies of 50 patients with sarcoidosis. Three types of granulomas are distinguished: macrophagal, florid and fading epithelioid-cell granulomas which are consequent stages of the granuloma transformation. Fibrosis arises in the macrophagal granuloma, is increasing in both epithelioid-cell granulomas and is ended by a formation of a small scar. Nonspecific liver changes were also found (hydropic and fat hepatocyte degeneration, hypertrophy and proliferation of the stellate reticulo-endotheliocytes, sinuses capillarization, lymphoid-histiocytic infiltration of the intralobular stroma and portal tract, step-like necrosis which are probably induced by the action of the sarcoidosis unknown etiological factor.
Nekrasova
T P
TP
Zolotarevskiĭ
V B
VB
Beketrova
T P
TP
Kornev
B M
BM
D000293:Adolescent; D000328:Adult; D000368:Aged; D002455:Cell Division / Q000502:physiology; D005260:Female; D006099:Granuloma / Q000473:pathology; D006505:Hepatitis / Q000473:pathology; D006801:Humans; D006984:Hypertrophy / Q000473:pathology; D008103:Liver Cirrhosis / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000473:pathology*
Morfologicheskie osobennosti pecheni pri sarkoidoze.