[The effect of nizoral on the function of the hypothalamo-hypophyseal-ovarian system in virilism].
A study is presented of the effect of nisoral on the hypothalamo-pituitary-ovarian system in 25 patients with hyperandrogenism (ovarian in 11, suprarenal in 14). It was established that most patients with oligomenorrhea and anovulation showed a restoration of the menstrual cycle after the 2-3 treatment courses and also absence of progression and reduction of the rate of pathological hair growth. After nisoral treatment the testosterone level decreased while estradiol and progesterone increased, gonadotropins remained unchanged, urinary excretion of 17-ketosteroids reduced.
Manusharova
R A
RA
D000293:Adolescent; D000328:Adult; D004341:Drug Evaluation; D005260:Female; D006628:Hirsutism / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects* / Q000503:physiopathology; D007654:Ketoconazole / Q000627:therapeutic use*; D008599:Menstruation Disturbances / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology; D010053:Ovary / Q000187:drug effects* / Q000503:physiopathology; D014770:Virilism / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology
D007654:Ketoconazole
Vliianie nizorala na funktsional'noe sostoianie gipotalamo-gipofizarno-iaichnikovoĭ sistemy pri virilizme.