[Zinc content in pancreatic islets in experimental diabetes induced by chelating agents].
The zinc content in microresected islets of rabbits, mice, rats, and guinea pigs was determined by atom-absorption spectrophotometry. The content was found to be highest in rabbits, and diabetes was induced in them by chelating agents easily. Injection of dithizone or 8-(p-toluenesulfonylamine) quinoline failed to induce diabetes mellitus in mice, rats, and guinea pigs. It is concluded that diabetogenic chelating agents are capable of producing irreversible diabetogenic affection in those beta-cells which contain a critical concentration of reactant zinc.
Bavel'skiĭ
Z E
ZE
Zaviazkina
T V
TV
Moiseev
Iu S
IuS
Medvedev
V I
VI
D000818:Animals; D002614:Chelating Agents; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced* / Q000378:metabolism; D005260:Female; D006168:Guinea Pigs; D007515:Islets of Langerhans / Q000378:metabolism*; D008297:Male; D051379:Mice; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D015032:Zinc / Q000378:metabolism*
D002614:Chelating Agents; D015032:Zinc
Soderzhanie tsinka v pankreaticheskikh ostrovkakh i éksperimental'nyĭ diabet, vyzyvaemyĭ khelatoobrazovateliami.