Expression of insulin-like growth factor in adult and embryonic kidney.
Insulin-like growth factors (IGFs) I and II are proinsulin-like peptides. IGF I is produced in adult and embryonic kidney. It is likely that IGF I produced locally in adult kidney regulates processes of renal transport, metabolism and growth. Renal IGF I production is stimulated by growth hormone (GH) and by epidermal growth factor (EGF). The identity of additional factors that regulate IGF I gene expression in settings such as compensatory hypertrophy and diabetes mellitus is unknown. IGF I and IGF II produced in embryonic kidney promote the metanephrogenic process. The identity of factors that regulate metanephric IGF gene expression is yet to be determined.
Hammerman
M R
MR
Department of Internal Medicine, Washington University School of Medicine, St. Louis, Mo. 63110.
Ryan
G
G
Miller
S B
SB
D001345:Autoradiography; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D007668:Kidney / Q000737:chemistry* / Q000196:embryology / Q000254:growth & development; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D011869:Radioligand Assay; D017526:Receptor, IGF Type 1 / Q000032:analysis* / Q000378:metabolism
D007457:Iodine Radioisotopes; D017526:Receptor, IGF Type 1