title: A comparative study of total protein, total and lipid associated serum sialic acid levels in patients with Behçet's disease and control groups.
abstract: The current investigation was designed to determine the total serum sialic acid (TSA), lipid associated sialic acid (LASA), total protein (TP), and TSA/TP values for 16 patients with active form of Behçet's disease, 12 patients with other uveitis types (pathologic controls) and 22 normal individuals. Data analysis indicated significant differences in mean TSA, LASA and TSA/TP values in patients with Behçet's disease (95.6 +/- 15.3 mg/dl, 29.8 +/- 7.4 mg/dl and 12.9 +/- 2.1 mg/g, respectively) and in pathologic controls (75.8 +/- 8.1 mg/dl, 26.6 +/- 0.3 mg/dl and 10.0 +/- 0.9 mg/g, respectively) when compared to normal controls (59.5 +/- 7.5 mg/dl, 19.2 +/- 3.2 mg/dl and 8.2 +/- 0.9 mg/g, respectively) (p < 0.01). No significant difference was observed in mean LASA values in patients with Behçet's disease when compared to pathologic controls (p > 0.05). No significant difference was observed in mean TP values in patients with Behçet's disease (7.4 +/- 0.7 g/dl), normal controls (7.3 +/- 0.4 g/dl) and pathologic controls (7.5 +/- 0.6 g/dl) (p > 0.05). A statistically significant difference was observed between the patients with Behçet's disease and pathologic controls with respect to TSA, TSA/TP values (p < 0.01). The results indicated that TSA and TSA/TP is most useful for differentiating Behçet's disease from other forms of uveitis.
authors: Department of Ophthalmology, Erciyes University, Kayseri, Turkey.
authors: H
authors: H
authors: Doğan
authors: H
authors: H
authors: Paşaoğlu
authors: O F
authors: OF
authors: Ekinciler
authors: N
authors: N
authors: Tatlişen
mesh_terms: D001528:Behcet Syndrome / Q000097:blood*; D015415:Biomarkers; D001798:Blood Proteins / Q000032:analysis*; D006801:Humans; D008055:Lipids / Q000097:blood*; D019158:N-Acetylneuraminic Acid; D012794:Sialic Acids / Q000097:blood*; D014605:Uveitis / Q000097:blood
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D008055:Lipids; D012794:Sialic Acids; C054080:lipid-associated sialic acid; D019158:N-Acetylneuraminic Acid