Foetal warfarin syndrome--a complex airway problem. Case report and review of the literature.
Premature cartilaginous calcification and nasal hypoplasia following first trimester exposure to warfarin are known as the Foetal Warfarin Syndrome (FWS). There are over 40 cases reported in the literature, many of which describe breathing and feeding difficulties in the first few months of life. We report a case where a child had had difficulties breathing and feeding in the first months of life. These had been attributed to nasal hypoplasia. After proper ENT assessment the child benefitted from adenoidectomy. ENT surgeons should be aware of the syndrome as more women of child bearing age are taking warfarin following cardiac surgery and treatment of thromboembolic disease. ENT surgeons may be asked to review these children who often present with airway and feeding problems which have been attributed to nasal hypoplasia.
Mason
J D
JD
Department of ENT, Queens Medical Centre, Nottingham.
Jardine
A
A
Gibbin
K P
KP
D002114:Calcinosis / Q000139:chemically induced; D002357:Cartilage Diseases / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D015508:Nasal Obstruction / Q000139:chemically induced; D009666:Nose / Q000002:abnormalities*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D014859:Warfarin / Q000009:adverse effects*
D014859:Warfarin