Comparative activity of the topical quinolone OPC-7251 against bacteria associated with acne vulgaris.
The antibacterial activity of the topical quinolone OPC-7251 against bacteria commonly found in acne vulgaris was tested in vitro by an agar dilution method. The MIC50 was 0.25 mg/l for Propionibacterium acnes, 0.125 mg/l for Propionibacterium granulosum, 0.03 mg/l for Staphylococcus aureus and 0.06 mg/l for coagulase-negative staphylococci. Compared with seven other antibiotics tested (ciprofloxacin, penicillin, erythromycin, tetracycline, clindamycin, fusidic acid and gentamicin), OPC-7251 had potent activity against both propionibacteria and staphylococci and the lowest incidence of resistant strains.
Vogt
K
K
Institute of Medical Microbiology, Free University of Berlin, Germany.
Hermann
J
J
Blume
U
U
Gollnick
H
H
Hahn
H
H
Haustein
U F
UF
Orfanos
C E
CE
D000152:Acne Vulgaris / Q000382:microbiology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000494:pharmacology; D000891:Anti-Infective Agents, Local / Q000494:pharmacology; D024841:Fluoroquinolones; D006801:Humans; D008826:Microbial Sensitivity Tests; D011424:Propionibacterium / Q000187:drug effects*; D011425:Propionibacterium acnes / Q000187:drug effects*; D011807:Quinolizines / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D013210:Staphylococcus / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000891:Anti-Infective Agents, Local; D024841:Fluoroquinolones; D011807:Quinolizines; C062127:nadifloxacin