Biostability and blood-contacting properties of sulfonate grafted polyurethane and Biomer.
Sulfonate-containing polyurethanes were evaluated for in vivo biodegradation using subcutaneously implanted tensile bars. In addition, these anionically charged polyurethanes were evaluated for in vivo activation of human complement C3a and ex vivo platelet deposition in arteriovenously-shunted canines. The sulfonate derivatized polymers included laboratory synthesized polyurethane and Biomer. Other polymers used for references included Intramedic polyethylene, Silastic and a poly(ethylene oxide) based polyurethane. The biodegradation results indicated that Biomer and the laboratory sulfonated Biomer (both manufactured with stabilizers), remained mechanically stable, retaining both tensile strength and elasticity after 4 weeks of subcutaneous implantation. The unstabilized polyurethanes (with or without sulfonation), however, showed marked cracking and a loss of mechanical properties after the same period of subcutaneous implantation. Sulfonated polyurethanes depressed human complement C3a activation in plasma, as indicated by decreased levels of anaphylatoxin production. The results of canine ex vivo blood contacting experiments were conducted in both an acute and chronic model and demonstrated decreased platelet deposition and activation for the sulfonated polyurethanes.
Wabers
H D
HD
Department of Chemical Engineering, University of Wisconsin, Madison 53706.
McCoy
T J
TJ
Okkema
A T
AT
Hergenrother
R W
RW
Wolf
M F
MF
Cooper
S L
SL
D000042:Absorption; D000818:Animals; D001166:Arteriovenous Shunt, Surgical; D001673:Biodegradation, Environmental; D001790:Blood Physiological Phenomena; D003167:Complement Activation; D015926:Complement C3a / Q000502:physiology; D004285:Dogs; D004548:Elasticity; D006801:Humans; D010973:Platelet Adhesiveness; D011140:Polyurethanes / Q000737:chemistry*; D019736:Prostheses and Implants; D013451:Sulfonic Acids / Q000737:chemistry*; D013718:Tensile Strength; D014867:Water / Q000737:chemistry
D011140:Polyurethanes; D013451:Sulfonic Acids; D014867:Water; C031892:biomer; D015926:Complement C3a