Carcinoma of the vulva: critical analysis of survival and treatment of recurrences.
Survival analysis of 181 vulvar cancer patients shows that stage and lymph nodal spread remain the most important prognostic factors. Other prognostic elements are: depth of stromal infiltration, thickness and site of the lesion, vascular space invasion. Precise definition of these pathological prognostic elements may be obtained only after appropriate surgical pathological evaluation of the primary lesion and regional nodes. Treatment must be adequate in the cost-benefit balance and surgery is the cornerstone in vulvar cancer management. Risk of relapse is statistically correlated with site of primary tumour, depth of infiltration, lymph nodal invasion and vascular space invasion. The treatment of recurrence is personalized for different sites but surgery is the elective treatment of the local recurrences.
Onnis
A
A
Obstetrics and Gynaecology Institute, University of Padua.
Marchetti
M
M
Maggino
T
T
D000368:Aged; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000628:therapy; D009367:Neoplasm Staging; D011788:Quality of Life; D016019:Survival Analysis; D014846:Vulvar Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy