title: Changes in endogenous lipid excretion in rats fed diets containing non-heated and thermally oxidized olive oils.
abstract: The objective of this study was to determine the effects of diets containing non-heated and thermally oxidized olive oils on fecal endogenous lipids. Male Wistar rats were fed fat-free diets and diets supplemented with 12% non-heated, heated, and a 1:1 mixture of non-heated/heated olive oils. After a 15-day experimental period two groups of fecal lipids from major endogenous sources were quantitated: neutral sterols and fatty acids associated with intestinal microflora action. Fecal endogenous sterols, particularly cholesterol, were significantly higher when diets contained oil, and excretion increased as the dietary oil alteration increased. Similar results were obtained for endogenous fatty acids. Increments of fecal sterols, dependent on oil alteration, could be explained by impairments in triglyceride hydrolysis and subsequent effect on cholesterol micellar solubilization. Moreover, high concentrations of poorly digestible lipids may have led to intestinal microbial modifications.
authors: Institute for Fats and Their Derivatives, CSIC, Seville, Spain.
authors: G
authors: G
authors: Márquez-Ruiz
authors: M C
authors: MC
authors: Dobarganes
mesh_terms: D000818:Animals; D004083:Cholestanol / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D005227:Fatty Acids / Q000378:metabolism; D005243:Feces / Q000737:chemistry*; D006358:Hot Temperature; D050356:Lipid Metabolism; D008297:Male; D000069463:Olive Oil; D010938:Plant Oils / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D012855:Sitosterols / Q000378:metabolism
chemical_list: D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D000069463:Olive Oil; D010938:Plant Oils; D012855:Sitosterols; C025473:gamma-sitosterol; D004083:Cholestanol; D002784:Cholesterol; C021255:stigmastanol