title: Cell proliferation and thyroid neoplasia.
abstract: The classic experimental model of thyroid neoplasia using radiation as a mutagen followed by long-term goitrogen treatment gives rise to multiple tumours in rats. Radiation alone, with suppression of TSH produces no tumours, TSH-induced growth alone causes a low level of tumorigenesis. Cell proliferation in this model is therefore critical. Epimutation as well as mutation is important. Rodent and human thyroid tumours show a clear stepwise progression, associated with both morphological and oncogene changes. In experimental animals the finding that monoclonal adenomas and carcinomas induced in the presence of long-term high TSH retain TSH dependency suggests that the step in the tumour progression requiring the development of TSH independent growth is bypassed, explaining the frequency of tumour development in this model. Normal thyroid follicular cell growth is limited, and a genotoxic effect before the growth plateau is more effective in carcinogenesis than a genotoxic effect after a period of growth. These observations will be interpreted in relation to the importance of thyroid tumours in regulatory toxicology and the pathobiology of thyroid tumours in man.
authors: Department of Pathology, University of Wales College of Medicine, Cardiff, UK.
authors: E D
authors: ED
authors: Williams
mesh_terms: D000818:Animals; D002455:Cell Division; D006801:Humans; D013961:Thyroid Gland / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000209:etiology* / Q000473:pathology