G-protein mutations in thyroid tumors.
Tissue specific G-protein mutations have been found in differentiated thyroid cancer with a higher prevalence in tumors from German than from American patients. Since activating mutations of Gs are principally comparable to chronic TSH stimulation of these tumor-thyrocytes such mutations may predict changes in tumor development and patient prognosis. The fundamental background and recent results of studies on mutational activation of G-proteins are presented.
Goretzki
P E
PE
Department of Surgery, Heinrich-Heine-University Düsseldorf/Germany.
Simon
D
D
Röher
H D
HD
D019204:GTP-Binding Proteins / Q000235:genetics* / Q000502:physiology; D006801:Humans; D009154:Mutation; D013964:Thyroid Neoplasms / Q000235:genetics*
D019204:GTP-Binding Proteins