Hepatic function and indocyanine green clearance during and after prolonged anaesthesia with propofol.
We have studied the effects of propofol on hepatic function and clearance of indocyanine green (ICG) in 13 consecutive patients undergoing prolonged plastic and reconstructive surgery. Hepatic function was assessed using serum concentrations of liver-specific glutathione-S-transferase (GST). There were no significant changes in GST activity or plasma clearance of ICG throughout the study.
Murray
J M
JM
Department of Anaesthesia, Northern Ireland Regional Plastic Surgery Unit, Ulster Hospital, Belfast.
Trinick
T R
TR
D000328:Adult; D000368:Aged; D000771:Anesthesia, Intravenous; D005982:Glutathione Transferase / Q000097:blood; D006801:Humans; D007208:Indocyanine Green / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000502:physiology*; D008875:Middle Aged; D015742:Propofol / Q000494:pharmacology*; D013997:Time Factors
D005982:Glutathione Transferase; D007208:Indocyanine Green; D015742:Propofol