Haematoporphyrin derivatives: distribution in a living organism.
Pharmacokinetics of accumulation in organs and tissues was studied for two haematoporphyrin-based photosensitizers. These sensitizers, haematoporphyrin derivative (HpD) and an oligomeric haematoporphyrin (OHp), contained different amounts of monomeric fraction (25% and 5% respectively) and in OHp the macrocycles were bonded together with ether bonds. OHp was shown to accumulate in tumours in higher amounts than HpD. The maximal tumour to tissue concentration ratio for OHp was 6.7 observed 54 h after injection; the same ratio for HpD was 2.8 after 48 h.
Mironov
A F
AF
M.V. Lomonosov Institute of Fine Chemical Technology, Moscow, Russian Federation.
Seylanov
A S
AS
Seylanov
J A
JA
Pizhik
V M
VM
Deruzhenko
I V
IV
Nockel
A J
AJ
D000818:Animals; D002850:Chromatography, Gel; D005260:Female; D017324:Hematoporphyrin Derivative / Q000493:pharmacokinetics*; D006415:Hematoporphyrins / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics*; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D013058:Mass Spectrometry; D009132:Muscles / Q000378:metabolism*; D011838:Radiation-Sensitizing Agents / Q000493:pharmacokinetics*; D051381:Rats; D012513:Sarcoma, Experimental / Q000378:metabolism*; D014018:Tissue Distribution
D006415:Hematoporphyrins; D011838:Radiation-Sensitizing Agents; D017324:Hematoporphyrin Derivative