Seizures in a fetal lamb after cocaine exposure: a case report.
We report the chance observation of two generalized seizures in a fetal lamb that received cocaine. Cocaine was infused intravenously into a 138-day-old fetus while electrocortical (ECoG), electroocular (EOG), and neck electromyographic (EMG) activity were recorded. Fetal rapid eye movement (REM) and nonrapid eye movement (NREM) sleep were disrupted during the cocaine exposure and returned to a normal pattern after infusions were stopped. Seventy-two hours later, however, we recorded generalized seizures with ECoG spike and spike wave activity.
Peters
A J
AJ
Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville 32610-0294.
Abrams
R M
RM
Burchfield
D J
DJ
Gilmore
R L
RL
D000818:Animals; D003042:Cocaine / Q000008:administration & dosage / Q000633:toxicity*; D004569:Electroencephalography; D004576:Electromyography; D004585:Electrooculography; D005260:Female; D005315:Fetal Diseases / Q000139:chemically induced* / Q000503:physiopathology; D005333:Fetus / Q000187:drug effects* / Q000503:physiopathology; D005865:Gestational Age; D006801:Humans; D007262:Infusions, Intravenous; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology; D012756:Sheep / Q000502:physiology*; D012890:Sleep / Q000187:drug effects; D012895:Sleep, REM / Q000187:drug effects
D003042:Cocaine