The role of hsp90 in fungal infection.
The immunodominant antigens of many microbial pathogens are heat shock proteins (hsps). In systemic candidal infections, a major target of protective antibody is an epitope shared with human hsp90. Here, Ruth Matthews and James Burnie suggest that fungal hsp90 plays a key pathogenic role in systemic infection by either binding to certain serum proteins, causing them to malfunction, or by mimicking the functional activity of other proteins.
Matthews
R
R
Department of Medical Microbiology, Manchester University Medical School, UK.
Burnie
J
J
D000595:Amino Acid Sequence; D000818:Animals; D000908:Antibodies, Fungal / Q000276:immunology / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use; D000946:Antigens, Fungal / Q000276:immunology*; D001665:Binding Sites; D001798:Blood Proteins / Q000378:metabolism; D002176:Candida albicans / Q000276:immunology*; D002177:Candidiasis / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology; D003429:Cross Reactions; D005656:Fungal Proteins / Q000276:immunology*; D006360:Heat-Shock Proteins / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D007116:Immunization, Passive; D016867:Immunocompromised Host; D016056:Immunodominant Epitopes / Q000235:genetics / Q000276:immunology*; D015994:Incidence; D051379:Mice; D008969:Molecular Sequence Data; D010215:Papio / Q000276:immunology; D011485:Protein Binding; D011487:Protein Conformation; D011817:Rabbits; D013045:Species Specificity
D000908:Antibodies, Fungal; D000911:Antibodies, Monoclonal; D000946:Antigens, Fungal; D001798:Blood Proteins; D005656:Fungal Proteins; D006360:Heat-Shock Proteins; D016056:Immunodominant Epitopes