The conformation of 6-methoxyerythromycin A in water determined by proton NMR spectroscopy.
The proton NMR spectrum of an aqueous solution of 6-methoxyerythromycin A (2) has been assigned and nuclear Overhauser effects have been obtained from a series of NOESY spectra. Carbon-13 antisymetric spin-lattice relaxation times have been measured for the methylene and methine carbons. The NMR data show that 2 is present exclusively in the keto form and has a conformation very similar to that reported for erythromycin A (1) in the solid and solution phases.
Steinmetz
W E
WE
Chemistry Department, Pomona College, Claremont, California 91711-6338.
Bersch
R
R
Towson
J
J
Pesiri
D
D
D017291:Clarithromycin / Q000737:chemistry*; D004917:Erythromycin / Q000031:analogs & derivatives*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation
D004917:Erythromycin; D017291:Clarithromycin