Hazard and probabilities of unknown genotypes.
The likelihood of a genotype of an unsampled individual depends upon genetic data from relatives. When these relatives may be carriers of a mutation as in X-linked disease, the likelihood of a genotype is altered by the consequences of the possible genotypes on offspring. The probabilities of the possible genotypes are easily derived from the probabilities conditional on the genotype obtained from a computer program aimed at risk calculation. This procedure of genotype reconstruction brings to light a potential hazard in the interpretation of computer data: a compound risk may be better represented as the harmonic mean of a set of conditional probabilities than the simple average of these probabilities.
Jeanpierre
M
M
Unité INSERM U129, CHU cochin, Paris, France.
D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D008957:Models, Genetic; D010375:Pedigree; D011336:Probability; D012307:Risk Factors
D005819:Genetic Markers