Rolipram inhibits PAF-induced airway microvascular leakage in guinea-pig: a comparison with milrinone and theophylline.
The effects of 3 phosphodiesterase (PDE) inhibitors, rolipram (PDE IV), milrinone (PDE III) and theophylline (non-selective) on PAF (50 ng kg-1; iv)-induced airway vascular leakage have been evaluated in guinea-pigs. Rolipram (3-300 micrograms kg-1; iv) reduced the increase in permeability induced by PAF at all airway levels whereas milrinone (10-1000 micrograms kg-1; iv) and theophylline (30 mg kg-1; iv) were without effects. The anti-leakage activity of rolipram may be of therapeutic value in asthma.
Ortiz
J L
JL
Departament de Farmacologia, Facultat de Medicina i Odontologia, Universitat València, Spain.
Cortijo
J
J
Vallés
J M
JM
Morcillo
E J
EJ
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects*; D005070:Evans Blue; D006168:Guinea Pigs; D020105:Milrinone; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D011728:Pyridones / Q000494:pharmacology; D011760:Pyrrolidinones / Q000494:pharmacology; D012137:Respiratory System / Q000098:blood supply / Q000187:drug effects*; D020889:Rolipram; D013806:Theophylline / Q000494:pharmacology
D010726:Phosphodiesterase Inhibitors; D010972:Platelet Activating Factor; D011728:Pyridones; D011760:Pyrrolidinones; D005070:Evans Blue; D013806:Theophylline; D020105:Milrinone; D020889:Rolipram