Dermal toxicity of paraphenylenediamine.
The guinea pigs were dermally exposed to paraphenylenediamine (PPD) and in presence of an oxidising agent hydrogen peroxide for 15 and 30 d to assess their effects on some enzymes, lipid peroxidation and histamine contents in the skin. The activities of acid and alkaline phosphatases, beta-glucuronidase, gamma glutamyl transpeptidase, histidase and tyrosinase were enhanced after application of either PPD or PPD plus hydrogen peroxide. The lipid peroxidation and histamine contents also showed marked elevation following exposure to the chemicals.
Mathur
A K
AK
Industrial Toxicology Research Centre, Lucknow, India.
Gupta
B N
BN
Singh
S
S
Singh
A
A
Narang
S
S
D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D004338:Drug Combinations; D005966:Glucuronidase / Q000378:metabolism; D006168:Guinea Pigs; D006632:Histamine / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D010655:Phenylenediamines / Q000633:toxicity*; D012867:Skin / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure
D004338:Drug Combinations; D010655:Phenylenediamines; D006632:Histamine; D006861:Hydrogen Peroxide; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D005966:Glucuronidase; C029728:4-phenylenediamine