title: Galactose alpha 1-3 galactose and anti-alpha galactose antibody in normal and pathological pregnancies.
abstract: The galactose alpha 1-3 galactose (Gal alpha 1-3 Gal) residue is a carbohydrate widely distributed in many non-human mammals. Since Gal alpha 1-3 Gal residues are described on the cell surface of tumor cells, we have examined the possibility of their expression on human trophoblastic cells at different stages of placental implantation and in various pregnancy-associated conditions. Using immunohistochemical methods, Gal alpha 1-3 Gal was demonstrated on interstitial and vascular trophoblast during pregnancy. For villous trophoblast, the staining disappeared in second trimester pregnancies. The density of staining for Gal alpha 1-3 Gal was increased in highly invasive trophoblast (mole and choriocarcinoma) and decreased in poorly invasive specimens (spontaneous abortion, XO monosomia). No cells displaying Gal alpha 1-3 Gal at their surface were identified in some segments of spiral arteries from pre-eclamptic women. The anti-Gal antibody titer increased in the first trimester of pregnancy and in the sera of pre-eclamptic and eclamptic patients. These findings suggest that Gal alpha 1-3 Gal residues could be considered as markers for trophoblast invasive capacity and that the binding of maternal anti-Gal antibodies to the trophoblast could contribute to limit trophoblastic invasion and thus participate to the immunological control of implantation.
authors: Laboratory of Biology, University of Liege, Tour de Pathologie, Belgium.
authors: Y
authors: Y
authors: Christiane
authors: M
authors: M
authors: Aghayan
authors: H
authors: H
authors: Emonard
authors: A
authors: A
authors: Lallemand
authors: P
authors: P
authors: Mahieu
authors: J M
authors: JM
authors: Foidart
mesh_terms: D000906:Antibodies / Q000032:analysis*; D004187:Disaccharides / Q000032:analysis*; D004461:Eclampsia / Q000276:immunology / Q000378:metabolism*; D005260:Female; D005690:Galactose / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D011225:Pre-Eclampsia / Q000276:immunology / Q000378:metabolism*; D011247:Pregnancy / Q000276:immunology / Q000378:metabolism*; D012016:Reference Values; D014327:Trophoblasts / Q000502:physiology*
chemical_list: D000906:Antibodies; D004187:Disaccharides; C055075:galactosyl-(1-3)galactose; D005690:Galactose