[Determination of basal and stimulated blood gastrin in duodenal ulcer].
Serum gastrin levels were measured under basal conditions and after hyperproteic meal stimulation in 24 patients with non-stenotic duodenal ulcer, 78% of them were males with a mean age of 36.4 years. Results were compared with those obtained in 20 volunteers. Basal gastrin levels in patients with duodenal ulcer 46.2 +/- 17.5 pg/ml did not show any significant statistical differences when compared with those in the control group (51.01 +/- 28.1 pg/ml). After meal stimulation gastrin levels at different time intervals, were similar in patients with duodenal ulcer and in the control group. We conclude that serum gastrin does not seem to play a relevant pathogenic role in the development of duodenal ulcer; its measurement is of no value as a biological marker of duodenal ulcer disease.
Núñez Peña
J R
JR
Departamento de Medicina Nuclear, Hospital Universitario San Carlos, Facultad de Medicina, Universidad Complutense de Madrid.
Martínez Ramos
C
C
Lapeña
L
L
Polo
A
A
Sanz
L R
LR
De Gopegui
M R
MR
Jorgensen
T W
TW
Tamames
E S
ES
D000328:Adult; D001481:Basal Metabolism; D004044:Dietary Proteins / Q000378:metabolism; D004381:Duodenal Ulcer / Q000097:blood* / Q000378:metabolism; D004435:Eating; D005260:Female; D005755:Gastrins / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged
D004044:Dietary Proteins; D005755:Gastrins
Valoración de la gastrinemia basal y estimulada en la úlcera duodenal.