[Effect of a synthetic prostacyclin analog on kidney function and the system of regulation of blood coagulation in experimental acute renal failure].
The influence of a stable analogue of prostacyclin on the renal function and parameters of hemostasis was investigated in experiments on animals with the nephrotic form of acute renal insufficiency. Diuresis, glomerular filtration, water and sodium reabsorption in the presence of diminished intravascular coagulation were recovered after two injections of the compound in a dose of 115 micrograms/kg.
Kukharchuk
A L
AL
Gozhenko
A I
AI
Lille
Iu E
IuE
Loppe
M
M
D058186:Acute Kidney Injury / Q000188:drug therapy / Q000503:physiopathology*; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects / Q000502:physiology*; D001780:Blood Coagulation Tests; D004195:Disease Models, Animal; D004231:Diuresis / Q000187:drug effects / Q000502:physiology; D011464:Epoprostenol / Q000627:therapeutic use*; D005919:Glomerular Filtration Rate / Q000187:drug effects / Q000502:physiology; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology*; D007677:Kidney Function Tests; D008297:Male; D051381:Rats
D011464:Epoprostenol
Vliianie sinteticheskogo analoga prostatsiklina na funktsiiu pochek i sistemu reguliatsii agregatnogo sostoianiia krovi pri éksperimental'noĭ ostroĭ pochechnoĭ nedostatochnosti.