Mammalian small molecule methyltransferases: their structural and functional features.
Structural and functional features of mammalian S-adenosyl-methionine-dependent small molecule methyltransferases are reviewed. The methyltransferases have similar protomer molecular weights in the range of 25,000-35,000. Two common sequence motifs are found in all enzymes of known sequence. Whereas the kinetic mechanisms may be different, the methyltransferases in the free form bind S-adenosylmethionine. Most, if not all, of mammalian small molecule methyltransferases appear to have vicinal thiols in a catalytically important area of the enzyme.
Fujioka
M
M
Department of Biochemistry, Toyama Medical and Pharmaceutical University, Faculty of Medicine, Japan.
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008780:Methyltransferases / Q000737:chemistry / Q000378:metabolism*; D008969:Molecular Sequence Data; D012436:S-Adenosylmethionine / Q000378:metabolism; D017386:Sequence Homology, Amino Acid
D012436:S-Adenosylmethionine; D008780:Methyltransferases