[Pharmacokinetics of hypolipedemic agents. 9. The question of biliary excretion of the hypolipidemic agent ciprofibrate (1) (2-(4-(2,2-dichlorocyclopropyl)-phenoxy)-2-methylpropionic acid].
After oral administration of 200 mg Ciprofibrate (1) to 10 patients, who were cholecystectomated with subsequent T-drainage, 1 could be determined in the collected bile only as its 1-O-beta-acylglucuronide to a very small amount. Approximative calculations have shown that two days after a single dose, less than 0.5% of the administered dose of 1 is excreted on the biliary route. It is an unsolved problem if there is an increase of biliary excretion after multiple dose.
Oelschläger
H
H
Institut für Pharmazeutische Chemie, Johann Wolfgang Goethe-Universität Frankfurt am Main.
Rothley
D
D
Schröder
D
D
Scherm
S
S
D000368:Aged; D000369:Aged, 80 and over; D001646:Bile / Q000378:metabolism*; D002994:Clofibrate / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D000960:Hypolipidemic Agents / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged
D000960:Hypolipidemic Agents; D002994:Clofibrate
Zur Frage der biliären Ausscheidung des Lipidsenkers Ciprofibrat (1) (2-[4-(2,2-Dichlorcyclopropyl)-phenoxy]-2-methylpropionsäure).