[Effect of naftidrofuryl on viscoelasticity, thrombocyte aggregation and erythrocyte fluidity of blood].
In 30 patients suffering from cerebrovascular disease stage I with atherosclerotic plaques in the carotid's bifurcation the effect of a 7-days application with 400 mg Naftidrofuryl versus NaCl was tested. As parameters viscosity and elasticity of whole blood, plasma viscosity, erythrocytes' and membrane fluidity point, as well as platelet aggregation (spontaneous, ADP-, Epinephrine- and Collagen-induced) were determined before onset, after 4 days and after 8 days. After 8 days treatment with naftidrofuryl there was a significant improvement in viscosity and elasticity of whole blood as well as in erythrocytes' elongation, membrane-fluidity and in the induced test of platelet aggregation.
Költringer
P
P
Krankenhaus Barmherzige Brüder Graz-Eggenberg.
Langsteger
W
W
Reisecker
F
F
Eber
O
O
D000368:Aged; D001809:Blood Viscosity / Q000187:drug effects*; D002343:Carotid Artery, Internal; D016893:Carotid Stenosis / Q000097:blood / Q000188:drug therapy*; D004907:Erythrocyte Deformability / Q000187:drug effects*; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009257:Nafronyl / Q000627:therapeutic use*; D010865:Pilot Projects; D010974:Platelet Aggregation / Q000187:drug effects*
D009257:Nafronyl
Die Wirkung von Naftidrofuryl auf die Viskoelastizität, die Thrombozytenaggregation und die Erythrozytenfluidität des Blutes.