Differential expression of two forms of annexin 3 in human neutrophils and monocytes and along their differentiation.
A variant of annexin 3 (AX3) of apparent mass 36 kD has been detected in human monocytes using a specific immune serum directed against the original 33-kD form of AX3 purified from human placenta. This protein is not a phosphorylated or a glycosylated form of the 33-kD AX3 and its expression increased along monocytic differentiation whereas only the 33-kD AX3 accumulated in neutrophils. This suggests that these two forms of AX3 may play specific roles in these phagocytic cells.
Le Cabec
V
V
INSERM U332, Institut Cochin de Génétique Moléculaire, Paris, France.
Russo-Marie
F
F
Maridonneau-Parini
I
I
D017318:Annexin A3 / Q000096:biosynthesis* / Q000302:isolation & purification; D002118:Calcium; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D005260:Female; D006801:Humans; D007106:Immune Sera; D008970:Molecular Weight; D009000:Monocytes / Q000166:cytology* / Q000502:physiology*; D009504:Neutrophils / Q000166:cytology* / Q000502:physiology*; D010920:Placenta / Q000502:physiology; D011247:Pregnancy; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D007106:Immune Sera; D017318:Annexin A3; D013755:Tetradecanoylphorbol Acetate; D002118:Calcium; D004121:Dimethyl Sulfoxide