title: Ascaris hemoglobin gene: plant-like structure reflects the ancestral globin gene.
abstract: Animal globin genes have two introns at strictly conserved positions, while plant globin genes have both of these as well as an additional, central intron. It has been proposed that a common ancestor gene had three introns, one of which was subsequently lost from animal but not plant globin genes. We have elucidated the cDNA sequence and gene structure of a hemoglobin from the parasitic nematode Ascaris suum and found a plant-like central intron, providing strong evidence for a three-intron ancestor of modern globin genes.
authors: Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
authors: D R
authors: DR
authors: Sherman
authors: A P
authors: AP
authors: Kloek
authors: B R
authors: BR
authors: Krishnan
authors: B
authors: B
authors: Guinn
authors: D E
authors: DE
authors: Goldberg
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001200:Ascaris / Q000235:genetics*; D001483:Base Sequence; D005075:Biological Evolution; D004247:DNA / Q000235:genetics; D005796:Genes; D017343:Genes, Plant; D005914:Globins / Q000235:genetics*; D007438:Introns; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D016133:Polymerase Chain Reaction; D016415:Sequence Alignment
chemical_list: D009838:Oligodeoxyribonucleotides; D005914:Globins; D004247:DNA