[Effects of verapamil on the development of pain syndrome in rats after section of the sciatic nerve].
The effect of daily verapamil administration (5 mg/kg) on pain sensitivity, bioelectric activity of cerebral cortex and microcirculation was studied in rats with cut sciatic nerve. Verapamil untreated rats showed hyperalgesia, autotomies and hypersynchronic discharges in contralateral hemisphere, increased range of evoked potentials and disorders in microcirculatory system which evidence developing pain syndrome. Early introduction of verapamil after the nerve cut prevented the emergence of pain syndrome.
Kryzhanovskiĭ
G N
GN
Reshetniak
V K
VK
Kukushkin
M L
ML
Gorizontova
M P
MP
Smirnova
V S
VS
D000818:Animals; D005071:Evoked Potentials; D008297:Male; D008833:Microcirculation; D010146:Pain / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000601:surgery*; D013003:Somatosensory Cortex / Q000503:physiopathology; D013577:Syndrome; D014700:Verapamil / Q000008:administration & dosage / Q000494:pharmacology*
D014700:Verapamil
Vliianie verapamila na razvitie bolevogo sindroma u krys posle pererezki sedalishchnogo nerva.