title: Athymic experimental animals in pharmaco-immunological research.
abstract: Immunodeficient animals--the nude mouse and the nude rat--allow studies of drug action and possible side effects without interference from the immune system. Comparative investigations in athymic and euthymic animals allowed us to elucidate the role of T-lymphocytes in the pathogenesis of streptozotocin-induced diabetes mellitus in mice, and the importance of NK-cells as effectors in guanethidine-induced sympathectomy in the rat. It is suggested that immunodeficient animals should be included in toxicological studies of xenobiotics.
authors: Dept. of Biological Sciences, Royal Danish School of Pharmacy, Copenhagen, Denmark.
authors: P
authors: P
authors: Juul
authors: H B
authors: HB
authors: Christensen
authors: H P
authors: HP
authors: Hougen
authors: O
authors: O
authors: Svendsen
authors: P
authors: P
authors: Thygesen
authors: J
authors: J
authors: Rygaard
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000209:etiology*; D006145:Guanethidine / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000502:physiology; D051379:Mice; D008819:Mice, Nude; D051381:Rats; D011923:Rats, Nude; D013563:Sympathectomy, Chemical; D013601:T-Lymphocytes / Q000502:physiology*
chemical_list: D006145:Guanethidine