Transgenes in autoimmunity.
The ability of transgenic mice to express a specific protein in a specific tissue has enabled the mechanisms of self-tolerance and autoimmunity to be elucidated. Further studies, combined with more sophisticated methods of gene targeting, will provide insights into the pathway leading from loss of self-tolerance to autoimmunity.
Lee
M S
MS
Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037.
Sarvetnick
N
N
D000818:Animals; D015551:Autoimmunity / Q000235:genetics* / Q000276:immunology; D016207:Cytokines / Q000235:genetics; D005803:Genes, Immunoglobulin / Q000235:genetics; D005814:Genes, Viral / Q000235:genetics; D008285:Major Histocompatibility Complex / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic / Q000276:immunology*; D011518:Proto-Oncogene Proteins / Q000235:genetics; D019253:Proto-Oncogene Proteins c-bcl-2; D011948:Receptors, Antigen, T-Cell / Q000235:genetics
D016207:Cytokines; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D011948:Receptors, Antigen, T-Cell