[Plasma interleukin-6 in patients with disseminated intravascular coagulation].
Plasma Interleukin-6 (IL-6) level was measured in 60 patients with disseminated intravascular coagulation (DIC). Plasma IL-6 level was high in patients with DIC, and was particularly high in patients with multiple organ failure (MOF) or poor prognosis. Plasma IL-6 level correlated positively with C-reactive protein in patients without DIC, but not in those with DIC. The increased plasma IL-6 level observed in DIC patients suggests that activation of the immune system is involved in the progression of DIC and in the pathology of organ failure.
Minamikawa
K
K
2nd Department of Internal Medicine, Mie University School of Medicine.
Wada
H
H
Ohiwa
M
M
Kaneko
T
T
Tsukada
T
T
Kageyama
S
S
Kobayashi
T
T
Tomeoku
M
M
Katou
M
M
Minami
N
N
D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000276:immunology; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D009102:Multiple Organ Failure / Q000097:blood; D011379:Prognosis
D015850:Interleukin-6; D002097:C-Reactive Protein