Effect of cimetidine on peripheral blood lymphocytes from chronic uremic patients: improvement of burst-promoting activity.
We have studied the in vitro effect of cimetidine, an inhibitor of suppressor T lymphocytes, on T lymphocytes of 6 uremic subjects and on normal T lymphocytes preincubated with the serum from the same patients. Cimetidine has been shown to increase the burst-promoting activity (BPA) of uremic T lymphocytes and to partially improve the BPA of normal T lymphocytes preincubated with uremic serum. The present study shows that suppressor T lymphocytes are not affected by uremic inhibitors and that chronic uremia, besides inducing a decrease in the number of helper T lymphocytes, impairs their ability to stimulate the BFU-E in vitro growth.
Morra
L
L
Department of Internal Medicine, University of Genova, Italy.
Moccia
F
F
Gurreri
G
G
Ponassi
G A
GA
Casti
P
P
Mela
S
S
D000328:Adult; D000368:Aged; D002478:Cells, Cultured; D002927:Cimetidine / Q000494:pharmacology*; D003114:Colony-Forming Units Assay; D015672:Erythroid Precursor Cells / Q000166:cytology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D013601:T-Lymphocytes / Q000187:drug effects* / Q000502:physiology*; D014511:Uremia / Q000097:blood* / Q000628:therapy
D002927:Cimetidine