Sequence similarity between HLA-DR1 and DR4 subtypes associated with rheumatoid arthritis and proteus/serratia membrane haemolysins.
Rheumatoid arthritis (RA) is found more often in subjects carrying the HLA-DR1 antigen and some subtypes of the HLA-DR4 antigen than in those without these antigens. Analysis of probes specific for HLA-DR4 has shown that amino acids encoding positions 69-74 (EQRRAA) of the beta chain indicates susceptibility to RA. A hexamer sequence of proteus haemolysin spanning residues 32-37 (ESRRAL) has been identified which resembles biochemically, and discriminates by charge, between HLA types associated with RA (DR1, Dw4, Dw14, Dw15), and those not linked with the disease (Dw10, Dw13).
Ebringer
A
A
Division of Biomolecular Sciences, King's College, London, United Kingdom.
Cunningham
P
P
Ahmadi
K
K
Wrigglesworth
J
J
Hosseini
R
R
Wilson
C
C
D000595:Amino Acid Sequence; D000942:Antigens, Bacterial / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D004198:Disease Susceptibility; D006681:HLA-D Antigens / Q000235:genetics; D015798:HLA-DR1 Antigen / Q000235:genetics*; D015804:HLA-DR4 Antigen / Q000235:genetics*; D006460:Hemolysin Proteins / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D011511:Proteus / Q000276:immunology*; D017386:Sequence Homology, Amino Acid
D000942:Antigens, Bacterial; D006681:HLA-D Antigens; D015798:HLA-DR1 Antigen; D015804:HLA-DR4 Antigen; C050381:HLA-Dw14 antigen; C067986:HLA-Dw15; C053495:HLA-Dw4 antigen; D006460:Hemolysin Proteins