title: Evaluation of hypercholesterol diet-induced changes in viscoelastic properties of carotid circulation in pigs.
abstract: Measurements of pulsatile pressure and flow at the input of the left and right carotid arteries and a new lumped parameter model were used to quantify changes in the overall dynamic mechanical properties of the carotid circulation between five control diet-fed pigs and five pigs fed a hyperlipidemic diet for 16 wk. The model represents the portion of the circulation supplied by either the left or the right carotid artery and is characterized by five parameters: peripheral resistance (Rp), an overall inertance (L), and an overall frequency-dependent compliance constituted by a capacitor C (static compliance) in series with a Maxwell section, i.e., a capacitor Cd, in parallel with a resistor Rd. Rp was calculated as the ratio between mean pressure (P) and mean flow (Q). The other four parameters were estimated by fitting measured to model predicted flows. The average static compliance was reduced by 40% (P = 0.01) between normal (P = 62.0 +/- 4.3 mmHg) and hyperlipidemic diet-fed pigs (P = 62.7 +/- 4.7 mmHg). A significant reduction in the overall cross-sectional area was inferred from a 53% increase (P = 0.05) in L, whereas resistance vessel tone was unchanged as judged from estimates of Rp. No signs of occlusive disease were found in any of the animals.
authors: Department of Electronics and Automatica, University of Ancona, Italy.
authors: R
authors: R
authors: Burattini
authors: L
authors: L
authors: Montanari
authors: L J
authors: LJ
authors: Mulligan
authors: M S
authors: MS
authors: Cannon
authors: D R
authors: DR
authors: Gross
mesh_terms: D000818:Animals; D002339:Carotid Arteries / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology; D002791:Cholesterol, Dietary / Q000494:pharmacology*; D004548:Elasticity; D008955:Models, Cardiovascular; D013552:Swine; D014783:Viscosity
chemical_list: D002791:Cholesterol, Dietary