Toxic activities of venoms from nine Bothrops species and their correlation with lethality and necrosis.
The comparison of seven toxic activities contained in venoms from nine different species of Bothrops and the correlation of each activity with lethality and necrosis was the subject of this study. The haemorrhagic, coagulant, necrotizing, myotoxic, proteolytic and phospholipase activities were not equally distributed among the venoms studied except for the oedema-inducing activity which was almost equally distributed among them. The correlation coefficient was estimated for each activity in relation to lethality and necrosis induced by the venom. Lethality was significantly related to haemorrhagic and oedema-inducing activities, whereas the necrotizing activity showed significant correlation with phospholipase and coagulant activities. Proteolytic activity presented a significant inverse correlation with lethality.
Ferreira
M L
ML
Centro de Imunologia O.G. Bier, São Paulo, Brazil.
Moura-da-Silva
A M
AM
França
F O
FO
Cardoso
J L
JL
Mota
I
I
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D003435:Crotalid Venoms / Q000633:toxicity*; D004487:Edema / Q000139:chemically induced / Q000473:pathology; D010450:Endopeptidases / Q000032:analysis; D006470:Hemorrhage / Q000139:chemically induced / Q000473:pathology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009135:Muscular Diseases / Q000139:chemically induced / Q000473:pathology; D009336:Necrosis / Q000139:chemically induced* / Q000473:pathology; D010741:Phospholipases A / Q000378:metabolism; D013045:Species Specificity
D003435:Crotalid Venoms; D010741:Phospholipases A; D010450:Endopeptidases