A proposed mechanism of anticancer activity of indomethacin.
The exact mechanism of anticancer activity of indomethacin still remains unclear. In view of the gathered observations and ideas, I hypothesize that the effect of indomethacin may be related--at least in certain cases--to its antagonism to gastrin/cholecystokinin family of peptides and/or to its agonistic activity to thromboxane A2 and melatonin. Future experiments in this direction are required.
Szkudliński
M W
MW
Institute of Endocrinology, Medical Academy of Lódź, Poland.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy; D011453:Prostaglandins / Q000096:biosynthesis
D000970:Antineoplastic Agents; D011453:Prostaglandins; D007213:Indomethacin