title: Functional and biochemical characterization of osteoclast-like cells derived from giant cell tumours of bone.
abstract: Cells harvested from human giant cell tumours of bone were characterized on the basis of morphological features, proliferative capacity, total(AP) and tartrate resistant acid phosphatase (TRAP) activity, and hormonal response. Culture were formed by mononucleated and multinucleated cells. Mononucleated cells showed fibroblastic morphology, whereas multinucleated cells showed osteoclastic phenotype. We conclude that in these cultures mature osteoclasts and their mononuclear precursors are present.
authors: Istituto di Citomorfologia Normale e Patologica, Università di Chieti.
authors: M
authors: M
authors: Grano
authors: S
authors: S
authors: Colucci
authors: A
authors: A
authors: Portoghese
authors: G
authors: G
authors: Zambonin
authors: R
authors: R
authors: Barattolo
authors: M
authors: M
authors: Serra
authors: K
authors: K
authors: Scotlandi
authors: A
authors: A
authors: Teti
authors: A
authors: A
authors: Zambonin Zallone
mesh_terms: D001859:Bone Neoplasms / Q000737:chemistry / Q000473:pathology*; D005870:Giant Cell Tumors / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D010010:Osteoclasts / Q000502:physiology*; D014407:Tumor Cells, Cultured