Pituitary-dependent hyperadrenocorticism in a family of Dandie Dinmont terriers.
Adrenocortical function studies were performed in seven Dandie Dinmont terriers with pituitary-dependent hyperadrenocorticism. The ability of dexamethasone at a dose rate of 0.1 mg/kg body weight to suppress cortisol secretion was only moderate in four out of the six dogs tested. Concentrations of alpha-melanocyte-stimulating hormone in plasma were highly increased. Responses to stimulation with corticotrophin-releasing hormone and the dopamine-antagonist haloperidol, examined in three animals, were moderate or absent. These results indicate that adrenocortical stimulation, i.e. hyperadrenocorticotrophism, was caused by pituitary lesions which were functioning autonomously. In six of the seven animals there was a very close familial relationship and the coefficients of relationship and the coefficients of inbreeding were significantly higher than in a representative control population. It was concluded that these seven related terriers with hyperadrenocorticotrophism had the biochemical characteristics of de-novo neoplasms of proopiomelanocortin-producing cells, and there was evidence for a genetic involvement in tumorigenesis.
Scholten-Sloof
B E
BE
Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands.
Knol
B W
BW
Rijnberk
A
A
Mol
J A
JA
Middleton
D J
DJ
Ubbink
G J
GJ
D000230:Adenocarcinoma / Q000503:physiopathology / Q000662:veterinary; D000302:Adrenal Cortex / Q000187:drug effects / Q000503:physiopathology*; D000303:Adrenal Cortex Diseases / Q000503:physiopathology / Q000662:veterinary*; D000818:Animals; D003346:Corticotropin-Releasing Hormone; D003907:Dexamethasone; D004283:Dog Diseases / Q000235:genetics / Q000503:physiopathology*; D004285:Dogs; D005260:Female; D006220:Haloperidol; D006854:Hydrocortisone / Q000378:metabolism; D008297:Male; D010902:Pituitary Gland / Q000503:physiopathology*; D010911:Pituitary Neoplasms / Q000503:physiopathology / Q000662:veterinary
D003907:Dexamethasone; D003346:Corticotropin-Releasing Hormone; D006220:Haloperidol; D006854:Hydrocortisone