title: An experimental randomized study of five different ventilatory modes in a piglet model of severe respiratory distress.
abstract: OBJECTIVE
  To characterize different modes of pressure- or volume-controlled mechanical ventilation with respect to their short-term effects on oxygen delivery (DO2). Furthermore to investigate whether such differences are caused by differences in pulmonary gas exchange or by airway-pressure-mediated effects on the central hemodynamics.
  
  
  METHODS
  After inducing severe respiratory distress in piglets by removing surfactant, 5 ventilatory modes were randomly and sequentially applied to each animal.
  
  
  METHODS
  Experimental laboratory of a university department of Anesthesiology and Intensive Care.
  
  
  METHODS
  15 piglets after repeated bronchoalveolar lavage.
  
  
  METHODS
  Volume-controlled intermittent positive-pressure ventilation (IPPV) with either 8 or 15 cmH2O PEEP; pressure-controlled inverse ratio ventilation (IRV); pressure-controlled high-frequency positive-pressure ventilation (HFPPV) and pressure-controlled high frequency ventilation with inspiratory pulses superimposed (combined high frequency ventilation, CHFV). The prefix (L) indicates that lavage has been performed.
  
  
  RESULTS
  Measurements of gas exchange, airway pressures, hemodynamics, functional residual capacity (using the SF6 method), intrathoracic fluid volumes (using a double-indicator dilution technique) and metabolism were performed during ventilatory and hemodynamic steady state. The peak inspiratory pressures (PIP) were significantly higher in the volume-controlled low frequency modes (43 cmH2O for L-IPPV-8 and L-IPPV-15) than in the pressure-controlled modes (39 cmH2O for L-IRV, 35 cmH2O for L-HFPPV and 33 cmH2O for L-CHFV, with PIP in the high-frequency modes being significantly lower than in inverse ratio ventilation). The mean airway pressure (MPAW) after lavage was highest with L-IRV (26 cmH2O). In the ventilatory modes with a PEEP > 8 cmH2O PaO2 did not differ significantly and beyond this "opening threshold" MPAW did not further improve PaO2. Central hemodynamics were depressed by increasing airway pressures. This is especially true for L-IRV in which we found the highest MPAW and at the same time the lowest stroke index (74% of IPPV).
  
  
  CONCLUSIONS
  In this model, as far as oxygenation is concerned, it does not matter in which specific way the airway pressures are produced. As far as oxygen transport is concerned, i.e. aiming at increasing DO2, we conclude that optimizing the circulatory status must take into account the circulatory influence of different modes of positive pressure ventilation.
authors: Department of Anesthesiology and Intensive Care, University Hospital, Uppsala, Sweden.
authors: M
authors: M
authors: Lichtwarck-Aschoff
authors: J B
authors: JB
authors: Nielsen
authors: U H
authors: UH
authors: Sjöstrand
authors: E L
authors: EL
authors: Edgren
mesh_terms: D000403:Airway Resistance; D000818:Animals; D001784:Blood Gas Analysis; D004195:Disease Models, Animal; D005069:Evaluation Studies as Topic; D005652:Functional Residual Capacity; D006439:Hemodynamics; D006611:High-Frequency Jet Ventilation / Q000379:methods / Q000592:standards*; D007385:Intermittent Positive-Pressure Ventilation / Q000379:methods / Q000592:standards*; D008170:Lung Compliance; D010092:Oximetry; D010101:Oxygen Consumption; D011175:Positive-Pressure Respiration / Q000379:methods / Q000592:standards*; D011312:Pressure; D011659:Pulmonary Gas Exchange; D015203:Reproducibility of Results; D012128:Respiratory Distress Syndrome / Q000503:physiopathology / Q000628:therapy*; D013552:Swine; D013556:Swine, Miniature