Histamine release inhibition activity of bisbenzylisoquinoline alkaloids.
Eleven examples of bisbenzylisoquinoline alkaloids (head-to-head; 10, head-to-tail; 1) and one half molecule type (N-methylcoclaurine), were tested by in vitro histamine release inhibition assay. The order of the potency of the inhibitory effect was ranked thus: homoaromoline, aromoline, isotetrandrine, cepharanthine, fangchinoline, obaberine, and tetrandrine. The following substances, cepharanoline, berbamine, oxyacanthine, and cycleanine (head-to-tail structure) had no inhibitory effect. N-Methylcoclaurine showed an inhibitory effect comparable to that of fangchinoline.
Nakamura
K
K
Tochigi Research Laboratories, Kao Corporation, Tochigi, Japan.
Tsuchiya
S
S
Sugimoto
Y
Y
Sugimura
Y
Y
Yamada
Y
Y
D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D001593:Benzyl Compounds / Q000737:chemistry / Q000494:pharmacology*; D006633:Histamine Antagonists / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D011804:Quinolines / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D014407:Tumor Cells, Cultured
D000470:Alkaloids; D001593:Benzyl Compounds; D006633:Histamine Antagonists; D011804:Quinolines