title: Suppression of radiation-induced neoplastic transformation by overexpression of mitochondrial superoxide dismutase.
abstract: Manganese superoxide dismutase (MnSOD) scavenges toxic superoxide radicals produced in the mitochondria. Transfection of the human MnSOD gene into mouse C3H 10T1/2 cells resulted in production of active MnSOD, which was properly transported into mitochondria. Overexpression of MnSOD protected cells from radiation-, but not chemically-induced neoplastic transformation. This finding demonstrates that oxidative stress that occurs in the mitochondria plays an important role in the development of neoplastic transformation.
authors: Graduate Center for Toxicology, University of Kentucky, Lexington 40506-0054.
authors: D K
authors: DK
authors: St Clair
authors: X S
authors: XS
authors: Wan
authors: T D
authors: TD
authors: Oberley
authors: K E
authors: KE
authors: Muse
authors: W H
authors: WH
authors: St Clair
mesh_terms: D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D004307:Dose-Response Relationship, Radiation; D016166:Free Radical Scavengers; D005720:Gamma Rays; D006801:Humans; D051379:Mice; D008809:Mice, Inbred C3H; D016253:Microscopy, Immunoelectron; D008928:Mitochondria / Q000201:enzymology* / Q000648:ultrastructure; D009368:Neoplasm Transplantation; D009381:Neoplasms, Radiation-Induced / Q000473:pathology / Q000517:prevention & control*; D012513:Sarcoma, Experimental / Q000473:pathology / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism*; D014162:Transfection
chemical_list: D016166:Free Radical Scavengers; D013482:Superoxide Dismutase