title: Epoxomicin, a new antitumor agent of microbial origin.
abstract: An actinomycete strain No. Q996-17 produced a novel compound, epoxomicin, which exhibited in vivo antitumor activity against B16 melanoma. Structural studies indicated that it is a new member of the epoxy-beta-aminoketone group, and is closely related to eponemycin.
authors: Bristol-Myers Squibb Research Institute, Tokyo, Japan.
authors: M
authors: M
authors: Hanada
authors: K
authors: K
authors: Sugawara
authors: K
authors: K
authors: Kaneta
authors: S
authors: S
authors: Toda
authors: Y
authors: Y
authors: Nishiyama
authors: K
authors: K
authors: Tomita
authors: H
authors: H
authors: Yamamoto
authors: M
authors: M
authors: Konishi
authors: T
authors: T
authors: Oki
mesh_terms: D000192:Actinomycetales / Q000378:metabolism*; D000577:Amides / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry / Q000627:therapeutic use; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000737:chemistry / Q000627:therapeutic use; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D008546:Melanoma, Experimental / Q000188:drug therapy; D015394:Molecular Structure; D009842:Oligopeptides; D012694:Serine / Q000031:analogs & derivatives / Q000627:therapeutic use; D013053:Spectrophotometry
chemical_list: D000577:Amides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D009842:Oligopeptides; C063282:eponemycin; D012694:Serine; C078846:epoxomicin