title: Heterogeneous airway tone in asthmatic subjects.
abstract: We examined the effect of volume history on the dynamic relationship between airways and lung parenchyma (relative hysteresis) in 20 asthmatic subjects. The acoustic reflection technique was employed to evaluate changes in airway cross-sectional areas during a slow continuous expiration from total lung capacity to residual volume and inspiration back to total lung capacity. Lung volume was measured continuously during this quasi-static maneuver. We studied three anatomic airway segments: extra- and intrathoracic tracheal and main bronchial segments. Plots of airway area vs. lung volume were obtained for each segment to assess the relative magnitude and direction of the airway and parenchymal hysteresis. We also performed maximal expiratory flow-volume and partial expiratory flow-volume curves and calculated the ratio of maximal to partial flow rates (M/P) at 30% of the vital capacity. We found that 10 subjects (group I) showed a significant predominance of airway over parenchymal hysteresis (P < 0.005) at the extra- and intrathoracic tracheal and main bronchial segments; these subjects had high M/P ratios [1.53 +/- 0.27 (SD)]. The other 10 subjects (group II) showed similar airway and parenchymal hysteresis for all three segments and significantly lower M/P ratios (1.16 +/- 0.20, P < 0.01). We conclude that the effect of volume history on the relative hysteresis of airway and lung parenchyma and M/P ratio at 30% of vital capacity in nonprovoked asthmatic subjects is variable. We suggest that our findings may result from heterogeneous airway tone in asthmatic subjects.
authors: Department of Medicine, University of Toronto, Ontario, Canada.
authors: G
authors: G
authors: Julia-Serda
authors: N A
authors: NA
authors: Molfino
authors: K R
authors: KR
authors: Chapman
authors: P A
authors: PA
authors: McClean
authors: N
authors: N
authors: Zamel
authors: A S
authors: AS
authors: Slutsky
authors: V
authors: V
authors: Hoffstein
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000502:physiology; D000403:Airway Resistance / Q000502:physiology*; D001249:Asthma / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008176:Lung Volume Measurements; D008297:Male; D009129:Muscle Tonus / Q000502:physiology; D015656:Respiratory Mechanics / Q000502:physiology; D012132:Respiratory Muscles / Q000503:physiopathology