[Interleukin 6 (IL-6)].
Interleukin 6 (IL-6) is a polypeptide mediator regulating immune response, acute phase reaction and hematopoiesis. Disregulating production of IL-6 was suggested to be involved in a variety of chronic inflammatory diseases. IL-6 is an autocrine growth factor for cultured mesangial cells. IL-6 was localized in the mesangial area of the kidney tissue and intraglomerular expression of mRNA, encoding for IL-6 gene, was observed in patients with mesangial proliferative glomerulonephritis (mes PGN). Furthermore, mesangial proliferation was observed in IL-6 transgenic mice. These results suggest that IL-6 is closely associated with the pathogenesis of mesPGN.
Dohi
K
K
1st Dept of Internal Medicine, Nara Medical University.
Iwano
M
M
Horii
Y
Y
D000818:Animals; D002478:Cells, Cultured; D005920:Glomerular Mesangium / Q000166:cytology / Q000378:metabolism; D006801:Humans; D015850:Interleukin-6 / Q000737:chemistry / Q000378:metabolism*; D007678:Kidney Glomerulus / Q000378:metabolism; D051379:Mice; D009393:Nephritis / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis; D011971:Receptors, Immunologic / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D019947:Receptors, Interleukin-6; D015398:Signal Transduction
D015850:Interleukin-6; D012333:RNA, Messenger; D011971:Receptors, Immunologic; D019947:Receptors, Interleukin-6