Fixed drug eruption of the scrotum due to methylphenidate.
OBJECTIVE
To report two cases of fixed drug eruption induced by methylphenidate.


METHODS
Two children with attention deficit disorder treated with methylphenidate as a simple drug developed fixed drug eruption of the scrotum. Drug discontinuation was followed by a complete resolution of the skin eruption. Rechallenge resulted in the same drug rash. Macrophage migration-inhibiting factor (MIF) assay with methylphenidate was positive.


CONCLUSIONS
The pathogenesis of fixed drug eruption and the role of MIF assay in the diagnosis of adverse drug reaction is discussed.


CONCLUSIONS
Fixed drug rash induced by methylphenidate is a possible but rare phenomenon.
Cohen
H A
HA
Department of Pediatrics, Hasharon Hospital, Sackler School of Medicine, Tel Aviv University, Petach Tikvah, Israel.
Ashkenazi
A
A
Nussinovitch
M
M
Gross
S
S
Frydman
M
M
D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy; D002648:Child; D003875:Drug Eruptions / Q000209:etiology*; D005832:Genital Diseases, Male / Q000139:chemically induced; D006801:Humans; D008263:Macrophage Migration-Inhibitory Factors / Q000032:analysis; D008297:Male; D008774:Methylphenidate / Q000009:adverse effects* / Q000627:therapeutic use; D012611:Scrotum
D008263:Macrophage Migration-Inhibitory Factors; D008774:Methylphenidate