Effect of heta-starch colloidal solutions on reticuloendothelial phagocytic system (RES) function in burned and infected rats.
The biodistribution of the plasma expander colloidal solution, heta-starch (HES), has been examined in rats, subjected to thermal injury or sepsis. The ability of these solutions to alter RES phagocytic function of [99mTc]-sulphur colloid ([99mTc]SC) uptake in vivo has been examined. The biodistribution of radiolabelled HES has been determined in normal rats. The HES colloidal solution has no deleterious effect upon RES function in vivo in the thermally injured animals or the septic animals as compared to sham controls. In addition, the HES colloidal solution seemed to be distributed primarily within the liver, spleen and kidney, with a small amount residing in the lung. Thermal injury did not increase the uptake of this material by the lung. These results suggest that the use of HES in thermally injured and septic individuals has no deleterious effects on RES function, nor does it accumulate in the lungs, and hence, should be advocated for use in these situations.
Trop
M
M
Department of Pediatrics, Massachusetts General Hospital, Boston.
Schiffrin
E J
EJ
Callahan
R
R
Carter
E A
EA
D000818:Animals; D002056:Burns / Q000503:physiopathology*; D003102:Colloids / Q000008:administration & dosage / Q000494:pharmacology; D004195:Disease Models, Animal; D007275:Injections, Intravenous; D012157:Mononuclear Phagocyte System / Q000502:physiology*; D010586:Phagocytes / Q000502:physiology; D010952:Plasma Substitutes / Q000008:administration & dosage / Q000494:pharmacology*; D011552:Pseudomonas Infections / Q000503:physiopathology*; D051381:Rats; D012996:Solutions; D013213:Starch / Q000008:administration & dosage
D003102:Colloids; D010952:Plasma Substitutes; D012996:Solutions; D013213:Starch