Disposition kinetics and dosage regimen of sulfapyridine in buffalo (Bubalus bubalis).
The disposition kinetics and dosage regimen of sulfapyridine were studied in buffalo calves following a single intravenous dose of 100 mg/kg. Distribution half-life (t1/2 alpha) elimination half-life (t1/2 beta) and Vd (area) was 0.181 +/- 0.008 h, 13.4 +/- 0.52 h and 0.59 +/- 0.03 L kg-1, respectively. Total body clearance, which represents the sum of all clearance processes, and tissue/plasma (T/P) ratio were calculated to be 31.1 +/- 2.28 ml kg-1 h-1 and 2.25 +/- 0.09, respectively. A satisfactory intravenous dosage regimen of sulfapyridine in buffalo would be 104 mg/kg followed by 75 mg/kg at 24 h intervals.
Srivastava
A K
AK
Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University, Ludhiana, India.
Rampal
S
S
Chaudhary
R K
RK
D000818:Animals; D002020:Buffaloes / Q000378:metabolism*; D004334:Drug Administration Schedule / Q000662:veterinary; D006207:Half-Life; D008297:Male; D008954:Models, Biological; D013427:Sulfapyridine / Q000008:administration & dosage / Q000493:pharmacokinetics*
D013427:Sulfapyridine