Positive selection of V beta 2+ CD8+ T cells.
T cells bearing V beta 4, V beta 6, V beta 10, V beta 14, and V beta 17a are positively selected by MHC class I and/or class II molecules with poorly elucidated mechanisms. In this paper levels of V beta 2+ CD4+ and V beta 2+ CD8+ T cells from 33 inbred, five F1 hybrid, and 48 [(C58 x DBA/2)F1 x DBA/2] backcross mice have been examined. The results show that (i) V beta 2+ CD8+ T cells are positively selected by MHC class I H-2k molecules, (ii) this positive selection might be mediated by a non-H-2 ligand(s) in association with the Kk molecule, and (iii) inbred strains of mice, so far examined, do not have endogenous superantigens for deletion of V beta 2+ T cells.
Tomonari
K
K
Transplantation Biology Section, MRC Clinical Research Centre, Harrow, UK.
D000818:Animals; D002454:Cell Differentiation; D002469:Cell Separation; D003433:Crosses, Genetic; D005434:Flow Cytometry; D015329:Gene Rearrangement, T-Lymphocyte; D006183:H-2 Antigens / Q000235:genetics; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics / Q000276:immunology; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*; D012641:Selection, Genetic; D016176:T-Lymphocyte Subsets / Q000737:chemistry / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology
D006183:H-2 Antigens; D016693:Receptors, Antigen, T-Cell, alpha-beta