Sulphydryl-containing agents: a new approach to the problem of refractory peptic ulceration.
Refractory peptic ulceration is the term applied to those gastric and duodenal ulcers which remain unhealed despite active treatment for at least 3 months. Sulphydryl-containing agents stimulate the formation of gastrointestinal mucus, bind the oxygen-derived free radicals that mediate tissue damage and play an important role in protein synthesis. This is the first report which suggests that these agents stimulate the healing of refractory gastric and duodenal ulceration without any adverse events.
Salim
A S
AS
University Department of Surgery, Medical City, Baghdad, Iraq.
D000328:Adult; D000536:Aluminum Hydroxide / Q000627:therapeutic use; D000863:Antacids / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D002927:Cimetidine / Q000627:therapeutic use; D003545:Cysteine / Q000627:therapeutic use; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006801:Humans; D008276:Magnesium Hydroxide / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000188:drug therapy*; D013438:Sulfhydryl Compounds / Q000627:therapeutic use*; D014814:Vitamin U / Q000627:therapeutic use
D000863:Antacids; D000897:Anti-Ulcer Agents; D004338:Drug Combinations; D013438:Sulfhydryl Compounds; D014814:Vitamin U; C013591:aluminum hydroxide, magnesium hydroxide, drug combination; D000536:Aluminum Hydroxide; D002927:Cimetidine; D003545:Cysteine; D008276:Magnesium Hydroxide