title: Comparison of PET measurements of cerebral blood flow and glucose metabolism for the localization of human epileptic foci.
abstract: We compared the relative sensitivity of two interictal PET techniques, bolus injection of [15O] labeled water for estimation of cerebral blood flow (H2(15)O CBF-PET), and 18F 2-deoxyglucose (18FDG-PET) for cerebral glucose metabolism (CMRglc), and T2-weighted magnetic resonance imaging, in 28 patients with medically intractable complex partial seizures undergoing evaluation for surgery. There were statistically significant associations between lateralization by 18FDG-PET, and MRI, but not H2(15)O CBF-PET, and lateralization of the epileptic focus as defined by scalp-sphenoidal ictal EEG. Fifteen patients had surgery or subdural electrodes. 18FDG-PET was more closely associated with a good outcome than H2(15)O CBF-PET, which, in addition, showed hypoperfusion contralateral to the epileptic temporal lobe in several cases. H2(15)O sensitivity may have been reduced by technical factors, but 18FDG-PET appears to be more specific for localization of epileptic zones.
authors: Epilepsy Research Branch NINDS, NIH, Bethesda, MD 20892.
authors: D B
authors: DB
authors: Leiderman
authors: M
authors: M
authors: Balish
authors: S
authors: S
authors: Sato
authors: C
authors: C
authors: Kufta
authors: P
authors: P
authors: Reeves
authors: W D
authors: WD
authors: Gaillard
authors: W H
authors: WH
authors: Theodore
mesh_terms: D000328:Adult; D002560:Cerebrovascular Circulation; D004828:Epilepsies, Partial / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000503:physiopathology; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D014055:Tomography, Emission-Computed
chemical_list: D005947:Glucose