Pharmacokinetics and urinary excretion of sulfadiazine in buffalo calves.
Pharmacokinetics and urinary excretion of sulfadiazine were determined in buffalo calves following single oral administration (150 mg/kg). Kinetic evaluation of plasma levels was performed using a 2-compartment model. The absorption half-life and elimination half-life were 3.41 +/- 0.63 and 13.75 +/- 1.94 h, respectively. Based on this study, an optimal dosage regimen of sulfadiazine in buffalo calves would be 165 mg/kg, followed by 75 mg/kg at 12-h intervals. Sulfadiazine was mainly excreted in the urine as free amine, while the percentage of acetylated sulfadiazine was comparatively low.
Jain
S K
SK
Tierärztliche Hochschule Hannover, Institut für Pharmakologie, Toxikologie und Pharmazie, Germany.
Uppal
R P
RP
Garg
B D
BD
D000042:Absorption; D000107:Acetylation; D000284:Administration, Oral; D000818:Animals; D002020:Buffaloes / Q000378:metabolism* / Q000652:urine; D006207:Half-Life; D013411:Sulfadiazine / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine
D013411:Sulfadiazine