title: Anticonvulsive properties of calcitonin in rats.
abstract: The effect of human calcitonin and sodium valproate (VPA) on electrically induced seizures in rats was assessed. Intraperitoneal administration of calcitonin (20 and 40 IU/kg) 60 min prior to electroshock significantly reduced the duration of the seizures and their intensity. We also found that combined treatment with calcitonin (20 and 40 IU/kg i.p.) and VPA (100 mg/kg p.o.) did not enhance the anticonvulsant activity. These findings suggest that calcitonin exerts an anticonvulsant influence on rats during electrically induced seizures.
authors: Department of Neurology, Medical School Białystok, Poland.
authors: W
authors: W
authors: Sobaniec
authors: W
authors: W
authors: Kułak
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002116:Calcitonin / Q000494:pharmacology*; D004558:Electric Stimulation; D004597:Electroshock; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014635:Valproic Acid / Q000494:pharmacology
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid; D002116:Calcitonin