title: Familial dyslipidaemic hypertension and other multiple metabolic syndromes.
abstract: Data from several different studies are reviewed suggesting that a subset of hypertension is associated with metabolic abnormalities involving lipids, insulin, and often obesity, all aggregating strongly in families. Persons with 'familial dyslipidaemic hypertension (FDH)' have an especially high risk of early coronary disease. The clinical and biochemical features of FDH are compared with Reaven's Syndrome X, familial combined hyperlipidaemia, dense LDL subfractions, diabetes, impaired glucose tolerance, central and general obesity, pre-diabetes, pre-hypertension, and heterozygous lipoprotein lipase deficiency. Some contribution from major gene effects is suggested in specific subsets reported in several different genetic studies reviewed in this report. It seems likely that multiple metabolic abnormalities are genetically heterogeneous. The data also suggest significant contributions from environmental factors such as diet and physical activity.
authors: Department of Medicine, University of Utah Health Sciences Center, Salt Lake City.
authors: R R
authors: RR
authors: Williams
authors: P N
authors: PN
authors: Hopkins
authors: S C
authors: SC
authors: Hunt
authors: M C
authors: MC
authors: Schumacher
authors: S C
authors: SC
authors: Elbein
authors: D E
authors: DE
authors: Wilson
authors: B M
authors: BM
authors: Stults
authors: L L
authors: LL
authors: Wu
authors: S J
authors: SJ
authors: Hasstedt
authors: J M
authors: JM
authors: Lalouel
mesh_terms: D003327:Coronary Disease / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000235:genetics*; D006973:Hypertension / Q000235:genetics*; D008071:Lipoprotein Lipase / Q000378:metabolism; D008297:Male; D008659:Metabolic Diseases / Q000235:genetics*; D010375:Pedigree; D013577:Syndrome
chemical_list: D008071:Lipoprotein Lipase