title: Urinary and amniotic epidermal growth factor during normal and abnormal pregnancies. A comparison based upon umbilical Doppler velocimetry.
abstract: Fetal growth retardation is associated with abnormal umbilical flow velocity. We have begun a systematic study of growth factors and their relationship to this specific pattern of growth retardation. Using a specific double-antibody epidermal growth factor (EGF) 125I-radioimmunoassay, we studied urinary EGF in normal pregnancy from 5 to 42 weeks of gestation, and amniotic fluid EGF from 18 to 24 weeks. EGF levels increased from early pregnancy until 21-28 weeks, when they declined to a level at term similar to non-pregnant controls and first-trimester pregnancy levels. There was no significant difference in urinary EGF levels between women delivering appropriate-for-gestational-age (AGA) infants, and those delivering small-for-gestational-age infants (SGA). We conclude that the urinary EGF is not different in the SGA pregnancy from normal pregnancy.
authors: Department of Obstetrics and Gynecology, Brookdale Hospital, Brooklyn, New York.
authors: A
authors: A
authors: Moharam
authors: F
authors: F
authors: Aleem
authors: G
authors: G
authors: Farmakides
authors: H
authors: H
authors: Schulman
authors: M
authors: M
authors: Maghzangy
authors: A
authors: A
authors: Rashed
authors: E
authors: E
authors: Konstantinou
mesh_terms: D000653:Amniotic Fluid / Q000378:metabolism*; D003404:Creatinine / Q000378:metabolism; D004815:Epidermal Growth Factor / Q000378:metabolism* / Q000652:urine*; D005260:Female; D005317:Fetal Growth Retardation / Q000378:metabolism* / Q000652:urine; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D010920:Placenta / Q000098:blood supply; D011247:Pregnancy; D014463:Ultrasonography; D014469:Umbilical Arteries / Q000000981:diagnostic imaging*
chemical_list: D004815:Epidermal Growth Factor; D003404:Creatinine