[Iga and IgG antireticuline in celiac disease. Their application as diagnostic markers of the disease].
We report the results of indirect immunofluorescent (IFI) detection of IgA and IgG antireticulin antibodies (IgA-ARA and IgG-ARA, respectively) in 283 serum samples from pediatric patients with coeliac disease (with and without gluten containing diets), patients with non-coeliac gastrointestinal disease, patients without gastrointestinal disease (control group) and patients with an increased risk for coeliac disease (diabetes mellitus, dermatitis herpetiformis or first grade relatives of coeliac patients). Our results indicate that IgA-ARA is a reproducible marker, with high positive (99-100%) and negative (100%) prediction values, when it is applied to children who have been on gluten containing diets for a long time (more than six months). The IgA-ARA measurement is not applicable in cases of selective IgA deficiency. Although IgG-ARA has a high predictive positive value, its low predictive negative value makes it a poor diagnostic tool. In the risk groups, our results suggest that these antibodies are useful in patient selection for intestinal biopsy.
Polo Martín
P
P
Servicio de Pediatría, Hospital General Universitario de Valencia.
Torregrosa Sánchez
R
R
Calabuig Sánchez
M
M
Martorrell Aragonés
A
A
Alvarez Angel
V
V
García Vila
A
A
D000293:Adolescent; D000470:Alkaloids / Q000037:antagonists & inhibitors / Q000276:immunology*; D044182:Benzylisoquinolines; D015415:Biomarkers; D002446:Celiac Disease / Q000175:diagnosis / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology*; D007223:Infant; D007546:Isoquinolines; D008297:Male
D000470:Alkaloids; D044182:Benzylisoquinolines; D015415:Biomarkers; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007546:Isoquinolines; C003298:reticuline
Estudio de la reactividad IgA e IgG antirreticulina en la enfermedad celíaca. Su aplicación como marcador diagnóstico de la enfermedad.