Malariometric survey in Keoudom District, Laos: sensitivity of Plasmodium falciparum to anti-malarials and automedication with chloroquine.
A malariometric survey was conducted in the Keoudom District, in the northern part of Vientiane Province, Laos, where an artificial dam-lake on the Nam River is located. The parasite rate of the whole cohort representing 1,105 subjects was 2.44% with the predominance of Plasmodium vivax (70%), while P. falciparum represented 30% with the average parasite density index 3. The low spleen rate (2.3%) characterized the study area as a hypoendemic zone. IFAT antibodies were examined in 419 subjects. The seropositivity of 195 persons < 15 years was 13.7% while in > 15 year old subjects seropositivity was 61.6% with a low GMRT in both groups (140:148). Automedication with aminoquinoline was assayed by urinary analysis in 125 outpatients. Of these, 36 (28.8%) were positive, 89 (71.2%) negative. The frequency of positive blood films for P. falciparum was higher in subjects with aminoquinoline in the urine (36.1%) than in those without (10.1%). Chloroquine sensitivity assay of 15 strains of P. falciparum displayed resistance in 39.3%.
Giboda
M
M
Institute of Parasitology, Czechoslovak Academy of Science, Ceske Budejovice.
Pholsena
K
K
Hongvanthong
B
B
Gutvirth
J
J
Rubik
I
I
D000293:Adolescent; D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D004197:Disease Reservoirs / Q000706:statistics & numerical data; D004351:Drug Resistance; D006801:Humans; D007223:Infant; D007812:Laos / Q000453:epidemiology; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology / Q000469:parasitology*; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000302:isolation & purification; D011803:Quinine / Q000627:therapeutic use; D012651:Self Medication / Q000706:statistics & numerical data; D016036:Seroepidemiologic Studies
D000913:Antibodies, Protozoan; D002738:Chloroquine; D011803:Quinine