title: PRAD1 (cyclin D1): a parathyroid neoplasia gene on 11q13.
abstract: Hyperparathyroidism is a central component of multiple endocrine neoplasia type 1 (MEN 1), and both sporadic and familial forms of parathyroid disease may share certain pathogenetic features. We recently identified a gene that is clonally rearranged with the PTH locus in a subset of sporadic parathyroid adenomas. This candidate oncogene, PRAD1 (previously D11S287), appears to contribute to parathyroid tumorigenesis in a fashion analogous to activation of C-MYC or BCL-2 by rearrangement with tissue-specific enhancers of the immunoglobulin genes in B-lymphoid neoplasia. The PRAD1 gene maps to 11q13 and has been linked to the BCL-1 breakpoint locus, although not to the most tightly linked MEN 1 markers, by pulsed field gel electrophoresis. PRAD1 may, in fact, be the long-sought BCL-1 lymphoma oncogene. PRAD1 encodes a novel type of cyclin protein and thus may normally function in controlling the cell cycle, perhaps through direct interaction with cdc2 or a related kinase. PRAD1's possible primary, or more likely secondary, involvement in the pathogenesis of MEN 1-related tumors is unknown and under investigation.
authors: Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114.
authors: A
authors: A
authors: Arnold
authors: T
authors: T
authors: Motokura
authors: T
authors: T
authors: Bloom
authors: C
authors: C
authors: Rosenberg
authors: A
authors: A
authors: Bale
authors: H
authors: H
authors: Kronenberg
authors: J
authors: J
authors: Ruderman
authors: M
authors: M
authors: Brown
authors: H G
authors: HG
authors: Kim
mesh_terms: D000595:Amino Acid Sequence; D002880:Chromosomes, Human, Pair 11; D016213:Cyclins / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D009857:Oncogenes / Q000235:genetics; D010282:Parathyroid Neoplasms / Q000235:genetics*
chemical_list: D016213:Cyclins