title: Piroxicam spares buprenorphine after total joint replacement. Controlled study of pain treatment in 81 patients.
abstract: In a blinded, placebo-controlled study, the nonsteroidal antiinflammatory drug piroxicam, in combination with the partial morphine agonist/antagonist buprenorphine, was compared with buprenorphine alone for analgesic effect and side-effects in a 10-day period following total replacement of the hip or knee. 117 patients entered and 81 completed the study. The patients receiving piroxicam consumed less buprenorphine. There were no differences concerning side-effects between the two treatment groups, apart from a tendency towards less nausea after the third postoperative day in the group receiving piroxicam.
authors: Rigshospitalet Department of Orthopedics, Copenhagen, Denmark.
authors: M E
authors: ME
authors: Boeckstyns
authors: M
authors: M
authors: Backer
authors: E M
authors: EM
authors: Petersen
authors: I
authors: I
authors: Høj
authors: H
authors: H
authors: Albrechtsen
authors: H B
authors: HB
authors: Andersen
mesh_terms: D002047:Buprenorphine / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006622:Hip Prosthesis; D006801:Humans; D007720:Knee Prosthesis; D010149:Postoperative Pain / Q000188:drug therapy*; D010894:Piroxicam / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D010894:Piroxicam; D002047:Buprenorphine