[Plasma-erythrocyte viscosity and evaluation of several pro- and anti-aggregating factors in NIDDM patients in metabolic decompensation state].
In NIDDM diabetic subjects, the microcirculatory damage shows a double aspect: an alteration of the vascular wall, particularly of the arteriolar capillary, and a hemorheological alteration at the level of the capillary district. In the microcirculation, because of the low velocity of the flow and the inverse relationship between capillary size and RBC diameter, the viscosity has an important role with its components: RBC viscosity and deformability. Even the erythrocyte aggregation has a key role as resultant of the attracting and repulsing forces, among which the plasma-RBC viscosity and the deformability play opposite role. Our method allows to evaluate the erythrocyte, the whole blood, the plasma and the plasma-RBC viscosity, and the deformability. Studies from this laboratory in NIDDM subjects show an increase in the blood viscosity, a decrease in the erythrocyte deformability and plasma-RBC viscosity. It is suggested that in microcirculatory district the flow reductions are particularly of hemorheological type and that the sludged blood is an "optical" phenomenon with poor meaning. We consider some hematological parameters, namely the Hgb A1c %, Hgb concentration, RBC count, MCV, etcetera.
Cortinovis
A
A
Dipartimento di Medicina Interna e Terapia Medica, Università degli Studi di Pavia.
Crippa
A
A
Crippa
M
M
Bosoni
T
T
Moratti
R
R
D000368:Aged; D000369:Aged, 80 and over; D001799:Blood Sedimentation; D001809:Blood Viscosity; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000378:metabolism; D004903:Erythrocyte Aggregation; D004907:Erythrocyte Deformability; D004912:Erythrocytes; D005260:Female; D006801:Humans; D008297:Male
Viscosità plasmaeritrocitaria e valutazione di alcuni fattori pro-aggreganti ed anti-aggreganti nei diabetici NID in stato di scompenso metabolico.