Increased uptake of T-kininogen by the liver in inflammatory conditions.
The distribution of [125I]T-kininogen in the liver of rats was found to be increased by laparotomy-, turpentine- or lipopolysaccharide-induced inflammation, whereas no such increase was observed in other organs or when 125I-labeled carboxymethylated T-kininogen, which does not inhibit cysteine proteinase, was used. These results suggest that the liver plays an important role in clearing T-kininogen from the circulation during inflammation.
Takano
M
M
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Japan.
Yayama
K
K
Miyawaki
Y
Y
Itoh
N
N
Okamoto
H
H
D000818:Animals; D001693:Biological Transport, Active; D007249:Inflammation / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D007704:Kininogens / Q000378:metabolism*; D008070:Lipopolysaccharides; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution; D014425:Turpentine
D007704:Kininogens; D008070:Lipopolysaccharides; D014425:Turpentine