Influence of carteolol and timolol on IOP an visual fields in glaucoma: a multi-center, double-masked, prospective study.
The influences of Carteolol and Timolol eye drops on intraocular pressure (IOP) and visual fields were compared in a multi-center, double-masked, prospective study. Two-hundred and forty eyes of 120 patients were initially included in the study, and 142 eyes of 72 patients fulfilled all the criteria for final statistical analysis. Both drugs significantly reduced IOP. The visual fields in both treatment groups did not change during one year of treatment. In both groups some patients improved slightly, and others deteriorated slightly. This indicates that locally applied beta-blockers may efficiently stop further progression of visual field defects in cases with increased IOP and early visual field damage. There was no difference between Carteolol and Timolol in this regard. The side effects were minimal, and there were no differences in their frequency or intensity in the two treatment groups.
Flammer
J
J
University Eye Clinic Basel, Switzerland.
Kitazawa
Y
Y
Bonomi
L
L
Mills
B
B
Fsadni
M
M
Dorigo
M T
MT
Shirato
S
S
Journel
B
B
Chavy
B
B
Chevallier
B
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D002354:Carteolol / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000503:physiopathology; D006339:Heart Rate; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000627:therapeutic use; D011446:Prospective Studies; D011680:Pupil; D013999:Timolol / Q000627:therapeutic use*; D014792:Visual Acuity; D058609:Visual Field Tests; D014794:Visual Fields / Q000187:drug effects*
D009883:Ophthalmic Solutions; D013999:Timolol; D002354:Carteolol