Intestinal gluten sensitivity: snapshots of an unusual autoimmune-like disease.
Gluten-sensitive disease is activated in genetically susceptible individuals by the ingestion of wheat protein (gluten). Breakdown in normal tolerogenic processes to dietary gluten is likely to play a primary pathogenic role. The disease is characterized by several autoimmune-type features and provides a model for studying autoimmune processes. A recent meeting emphasized the need for a clearer picture of the molecular interactions between disease triggering agents, molecules of the immune system and other products of disease susceptibility genes.
O'Farrelly
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Dept of Immunology, Trinity College, Dublin, Ireland.
Gallagher
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RB
D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D015984:Causality; D002446:Celiac Disease / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D005983:Glutens / Q000276:immunology*; D006239:Haplotypes; D006801:Humans; D007422:Intestines / Q000276:immunology / Q000473:pathology; D008285:Major Histocompatibility Complex
D005983:Glutens