title: Contributions of various serum proteins to the binding of prasterone sulfate in humans.
abstract: The binding of prasterone sulfate (PS) in human plasma was investigated. Binding percentages of PS to human plasma, human serum albumin (HSA), human alpha 1-acid glycoprotein (AGP) and human gamma-globulin (GGL) were independent of the PS concentration between 0.1 and 8.0 micrograms/ml. The mean binding percentages were 99.1% for human plasma, 98.3% for HSA, 12.6% for AGP and 8.1% for GGL. Though PS is an acidic drug, binding of PS to AGP was observed. From the binding index, it was found that PS mainly bound to HSA in human plasma and that the contributions of AGP and GGL to PS in plasma were negligible.
authors: Product Research and Development Laboratory, Kanebo, Ltd., Osaka, Japan.
authors: T
authors: T
authors: Sakai
authors: Y
authors: Y
authors: Adachi
authors: M
authors: M
authors: Yatomi
authors: N
authors: N
authors: Awata
mesh_terms: D000328:Adult; D001798:Blood Proteins / Q000378:metabolism*; D003687:Dehydroepiandrosterone / Q000097:blood*; D005260:Female; D006801:Humans; D011485:Protein Binding
chemical_list: D001798:Blood Proteins; D003687:Dehydroepiandrosterone