title: [Platelet adenylate cyclase activity in alcoholics].
abstract: Platelet adenylate cyclase (AC) activity in the long-term abstinent alcoholics, who maintained abstinence from alcohol for at least one year was examined. Guanine nucleotide [Gpp(NH)p] stimulated AC activity was not changed in platelet membrane from long-term abstinent alcoholics. However, the extent of AC activity induced by 250 mM ethanol in vitro, in the presence of 1 microM Gpp(NH)p, was significantly reduced in platelet membrane from long-term abstinent alcoholics. These results suggest that platelet AC activity may be a biological marker for alcoholics.
authors: Department of Neuropsychiatry, Sapporo Medical College, Hokkaido, Japan.
authors: T
authors: T
authors: Saito
authors: M
authors: M
authors: Watanabe
authors: Y
authors: Y
authors: Katamura
authors: E
authors: E
authors: Hashimoto
authors: A
authors: A
authors: Nabeshima
authors: T
authors: T
authors: Ashizawa
authors: N
authors: N
authors: Takahata
mesh_terms: D000262:Adenylyl Cyclases / Q000097:blood*; D000437:Alcoholism / Q000201:enzymology*; D015415:Biomarkers / Q000097:blood*; D001792:Blood Platelets / Q000201:enzymology*; D006801:Humans
chemical_list: D015415:Biomarkers; D000262:Adenylyl Cyclases