Leukoencephalopathy and major depression: a preliminary report.
The comparative prevalence of leukoencephalopathic changes in 119 young and old inpatients and outpatients with major depression was examined. Patients underwent magnetic resonance imaging (MRI) examinations with T1- and T2-weighted pulse sequences. Leukoencephalopathic changes were uncommon in depressed patients and medical control subjects younger than 45 years of age. Such changes were, however, seen in approximately 44% of older depressed patients and 30% of elderly medical control subjects.
Guze
B H
BH
Adult Psychiatry Inpatient Service, University of California, Los Angeles.
Szuba
M P
MP
D000328:Adult; D000368:Aged; D001284:Atrophy; D001921:Brain / Q000473:pathology; D003866:Depressive Disorder / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008297:Male; D019965:Neurocognitive Disorders / Q000175:diagnosis*