[Time of famotidine administration and healing of duodenal ulcer: is 18.00 o'clock of importance?].
In a double-blind, placebo-controlled two centre trial, the effect of a 40 mg oral dose of famotidine administered at 6 p.m. to the same dose given at 10:00 p.m. was studied in 38 patients with duodenal ulcers. After 2 weeks 61% of the ulcers had healed; this had risen to 89% by the end of week 4. The statistically non-significant trend to better results following administration later at night (which apparently contradicts other published results) may have been due to a delay in adsorption caused by food ingestion and the related nocturnal pH levels.
Brunner
H
H
I. Medizinischen Abteilung mit Gastroenterologie, Krankenhauses Wien-Lainz.
Weiss
W
W
D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004381:Duodenal Ulcer / Q000097:blood / Q000188:drug therapy*; D004384:Duodenoscopy; D015738:Famotidine / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D015738:Famotidine
Einnahmezeitpunkt von Famotidin und Heilung des Ulcus duodeni: Ist 18.00 Uhr von Bedeutung?