[Diagnostic performance of immunologic tests in amebic liver abscess using receiver operating characteristic curves].
Objectives. 1) To identify the tests of immunological diagnosis with a high diagnostic efficiency in amebic liver abscess. 2) To determine the ideal cutoff point for such tests. 3) To identify the influence degree of the antigen used over the test efficiency. Design. Comparative survey. Study units. Analysis of 24 articles identified in the medical literature about tests of immunological diagnosis in amebic liver abscess. Measurements. Starting from the articles, operating characteristics curves (ROC) were established derived from the test application to patients with amebic liver abscess. Results. A great variability in the diagnostic efficiency was identified between the various tests, even when the analysis was focused on the investigations of a specific test. It was not possible to conclude which test had a major degree of efficiency due to such variability. The cutoff level considered as relevant was higher than the one traditionally used for indirect hemagglutination and it had concordance with the one presently accepted for the fluorescence antibodies test. By maintaining steady the spectrum of the study patients and the type of test, variability among the tests persisted. This was due to the use of different antigens. Conclusions. A great variation in the diagnostic efficiency of the analyzed tests was identified. The variation source was the type of test, the antigen used and probably the illness spectrum.
Garduño-Espinosa
J
J
Unidad de Investigación Clínica en Enfermedades Infecciosas y Parasitarias, Instituto Mexicano del Seguro Social, México, D.F.
Martínez-García
M C
MC
Rendón-Macías
E
E
Fajardo-Gutiérrez
A
A
Hernández-Hernández
D M
DM
Muñoz-Hernández
O
O
D005069:Evaluation Studies as Topic; D006801:Humans; D007159:Immunologic Tests; D008101:Liver Abscess, Amebic / Q000175:diagnosis*; D011237:Predictive Value of Tests; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
Rendimiento diagnóstico de las pruebas inmunológicas en absceso hepático amibiano a través de curvas de características operantes del receptor.