[Experimental study on intramaxillary injection of fosfomycin. Effects of fosfomycin on experimental acute sinusitis in rabbits].
We studied effects of intramaxillary injection of fosfomycin (FOM) on experimental sinusitis in rabbits. The experimental sinusitis was induced by intramaxillary injection of Staphylococcus aureus to rabbits for 3 successive days. 1. 0.5, 1, 3 or 5% FOM with saline as a control was instilled into the maxillary sinus and the maxillary sinus mucosa were examined macroscopically and light and electron microscopically. 3% and 5% FOM suppressed the damage of mucosa macroscopically and scanning electron microscopically. 2. After administration of 3% FOM and saline twice a week, the maxillary sinus mucosa was examined macroscopically and light and electron microscopically. The maxillary sinus injected with 3% FOM showed almost normal mucosa after 2 weeks while that injected with saline showed severe mucosal damage. S. aureus were decreased by 3% FOM injection and not found in the maxillary sinus in a week. The results indicate that intramaxillary injection of FOM is very effective in the treatment of sinusitis.
Kobayashi
T
T
Department of Otolaryngology, Nagoya City University.
Baba
S
S
D000208:Acute Disease; D000818:Animals; D005578:Fosfomycin / Q000008:administration & dosage*; D007267:Injections; D008297:Male; D008443:Maxillary Sinus; D015523:Maxillary Sinusitis / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D011817:Rabbits; D013203:Staphylococcal Infections
D005578:Fosfomycin