Gene expression in mental illness: a navigation chart to future progress.
An initial course in disentangling complex causal interactions in psychiatric illnesses, we suggest, is finding co-familial traits with classical Mendelian segregation. Starting with non-Mendelian traits, three methods can be used to find underlying Mendelian phenotypes. (1) Statistically-inferred latent traits, with more nearly Mendelian transmission than the measures from which they are derived, can serve as pointers to concrete Mendelian phenotypes. (2) Linkage of non-Mendelian traits to genetic markers, if it can be established, can be followed by searching for phenotypes that discriminate carriers from non-carriers of the imputed trait gene. (3) In the long run, the most successful method is likely to be direct refinement of non-Mendelian behavioral and physiological traits into more fundamental components.
Matthysse
S
S
Mailman Research Center, McLean Hospital, Belmont, MA 02178.
Levy
D L
DL
Kinney
D
D
Deutsch
C
C
Lajonchere
C
C
Yurgelun-Todd
D
D
Woods
B
B
Holzman
P S
PS
D001714:Bipolar Disorder / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D002874:Chromosome Mapping; D005786:Gene Expression Regulation / Q000502:physiology*; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D001523:Mental Disorders / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D008957:Models, Genetic; D009483:Neuropsychological Tests; D010375:Pedigree; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics; D012565:Schizophrenic Psychology
D005819:Genetic Markers