Amino acid structure and "difficult sequences" in solid phase peptide synthesis.
Deprotection peak profiles have been determined as a measure of internal aggregation during Fmoc-polyamide continuous flow solid phase synthesis. The results have been correlated with amino-acid structure and discussed in terms of minimising aggregation during synthesis.
Bedford
J
J
MRC Laboratory of Molecular Biology, Cambridge, UK.
Hyde
C
C
Johnson
T
T
Jun
W
W
Owen
D
D
Quibell
M
M
Sheppard
R C
RC
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry*; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis*
D000596:Amino Acids; D010455:Peptides