title: Oxcarbazepine does not affect the anticoagulant activity of warfarin.
abstract: The possible interaction of the antiepileptic drug oxcarbazepine (OCBZ) on the anticoagulant effect of warfarin was investigated in 10 healthy male volunteers. After reaching steady-state conditions by repeated administration of warfarin, the prothrombin time (Quick value) was assessed before and after single (600 mg) and multiple dosing (450 mg twice daily in 1 week) of OCBZ. In 7 of the 10 volunteers with evaluable data, the prothrombin time was not significantly different (paired t test) from baseline either after single (p = 0.299) or repeated dosing (p = 0.333), indicating that OCBZ does not interact to any relevant extent with the hypothrombinemic effect of warfarin.
authors: Johannes Gutenberg University, Mainz, Germany.
authors: G
authors: G
authors: Krämer
authors: B
authors: B
authors: Tettenborn
authors: P
authors: P
authors: Klosterskov Jensen
authors: G P
authors: GP
authors: Menge
authors: K D
authors: KD
authors: Stoll
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D002220:Carbamazepine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006801:Humans; D008297:Male; D000078330:Oxcarbazepine; D011517:Prothrombin Time; D014859:Warfarin / Q000494:pharmacology*
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine; D014859:Warfarin; D000078330:Oxcarbazepine