[The preventive activity of monoclonal antibodies specific to the lipopolysaccharide of Francisella tularensis].
The preventive activity of five monoclonal antibodies (McAb) in experimental tularemia was evaluated. McAb produced by hybridoma FB11-k (IgG2a), specific to F. tularensis lipopolysaccharide, prevented the death of mice and guinea pigs infected with F. tularensis virulent strain 503 of the holarctic subspecies.
Khlebnikov
V S
VS
Vetchinin
S S
SS
Grechko
G K
GK
Averina
A A
AA
Golovlev
I R
IR
Averin
S F
SF
Zhemchugov
V E
VE
Konovalov
S I
SI
Anisimov
G A
GA
Afanas'ev
S S
SS
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology* / Q000302:isolation & purification; D000918:Antibody Specificity / Q000276:immunology*; D004353:Drug Evaluation, Preclinical; D005604:Francisella tularensis / Q000276:immunology* / Q000472:pathogenicity; D006168:Guinea Pigs; D006825:Hybridomas / Q000276:immunology; D008070:Lipopolysaccharides / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D013997:Time Factors; D014406:Tularemia / Q000276:immunology / Q000517:prevention & control*; D014774:Virulence / Q000276:immunology
D000911:Antibodies, Monoclonal; D008070:Lipopolysaccharides
Preventivnaia aktivnost' monoklonal'nykh antitel, spetsifichnykh k lipopolisakharidu Francisella tularensis.