Postoperative analgesia using a computerised infusion of alfentanil following aortic bifurcation graft surgery.
A Psion microcomputer controlled infusion system for alfentanil was assessed for the provision of post-operative analgesia in 14 patients who had undergone aortic bifurcation graft surgery. The system employed a pharmacokinetic model working in real time to deliver any selected target plasma concentration of alfentanil. The alfentanil infusion system was used for a mean time of 39 hours and for 96% of this time, patients were scored as having no pain or only mild pain. Severe pain was recorded for only 0.05% of the study time. The use of a pharmacokinetic delivery system may offer a convenient and simple method of providing postoperative analgesia with alfentanil.
Davies
F W
FW
University Department of Anaesthesia, Royal Infirmary, Glasgow, UK.
White
M
M
Kenny
G N
GN
D000328:Adult; D000368:Aged; D015760:Alfentanil / Q000008:administration & dosage* / Q000097:blood; D000698:Analgesia / Q000379:methods*; D001011:Aorta / Q000601:surgery*; D001807:Blood Vessel Prosthesis; D004360:Drug Therapy, Computer-Assisted; D005260:Female; D006801:Humans; D008297:Male; D008838:Microcomputers; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*
D015760:Alfentanil