title: [Studies on the synthesis of dimethyl 4-hydroxy-4'-methoxy-5,6,5',6'-bismethylenedioxy biphenyl-2,2'-dicarboxylate--an essential metabolite of biphenyl diester].
abstract: This paper reports the synthesis of dimethyl 4-hydroxy-4'-methoxy-5,6,5',6'-bismethylenedioxybiphenyl-2,2'-dica rboxylate (II). Various conditions for bromination were tried to find the best one for synthesis of the key intermediate compound 6. After Ullmann condensation of 6 with 8 and hydrogenolysis, the title compound II was obtained. It was proved to be identical with the isolated metabolite of biphenyl diester by spectral data.
authors: Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
authors: S L
authors: SL
authors: Zhan
authors: C Z
authors: CZ
authors: Zhang
mesh_terms: D001713:Biphenyl Compounds / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004149:Dioxoles / Q000138:chemical synthesis*
chemical_list: D001713:Biphenyl Compounds; D004149:Dioxoles; C043146:7-hydroxy-7'-methoxy-4,4'-bis(1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester