[Non-radioactive in situ hybridization of alpha-satellite sequences in cytogenetic diagnosis].
Non isotopic in situ hybridization with alpha-satellite DNA probes in the cytogenetic diagnosis. Standard banding cytogenetic techniques do not always allow to define the structure and the origin of chromosome rearrangements involving the centromere region. Non-isotopic in situ hybridization of alphoid sequences has allowed to determine the origin of the centromeres in the metaphases of 5 patients referred to us for: 2 structural rearrangements involving chromosome 21, 2 structural rearrangements involving chromosome Y and 1 reciprocal translocation involving on chromosome 20 and one chromosome 15.
Perfumo
C
C
Centro Studi Regionale Sindrome di Down, Genova.
Arslanian
A
A
Zara
F
F
Piombo
G
G
Pierluigi
M
M
D000022:Abortion, Spontaneous / Q000235:genetics; D000328:Adult; D002648:Child; D002869:Chromosome Aberrations / Q000473:pathology*; D025063:Chromosome Disorders; D002884:Chromosomes, Human, Pair 15 / Q000648:ultrastructure*; D002890:Chromosomes, Human, Pair 20 / Q000648:ultrastructure*; D002891:Chromosomes, Human, Pair 21 / Q000648:ultrastructure*; D015342:DNA Probes; D004276:DNA, Satellite / Q000032:analysis*; D004314:Down Syndrome / Q000235:genetics / Q000473:pathology; D004392:Dwarfism / Q000235:genetics; D005260:Female; D005819:Genetic Markers; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007231:Infant, Newborn; D008297:Male; D009845:Oligospermia / Q000235:genetics; D011247:Pregnancy; D014178:Translocation, Genetic; D014998:Y Chromosome / Q000648:ultrastructure*
D015342:DNA Probes; D004276:DNA, Satellite; D005819:Genetic Markers
Ibridazione in situ non radioattiva di sequenze alfa-satellite nella diagnostica citogenetica.