title: Association between blood transfusion and infection in injured patients.
abstract: The association between red blood cell transfusions and infectious complications in 484 patients with acute injuries was studied in 1989. The median age was 62 years (0.5-97) and the median stay 7 days (3-141). Infectious complications developed in 46 (9.5%) patients. A number of potential risk factors, except blood transfusion, were analyzed in a logistic regression model to determine significant predictors of infectious complications. Blood transfusion as a cofactor was then added to this model. The final logistic regression analysis showed a relationship between blood transfusions and infectious morbidity that was independent of the other significant factors; Injury Severity Score, age, and surgical procedure. The corrected odds ratios for infection were 1.6 (95% confidence interval: 0.7-3.7) when 1-4 units of blood were given and 6.4 (95% CI: 2.3-18.3) when more than 4 units were used.
authors: Department of Surgery, Innherred Hospital, Levanger, Norway.
authors: T H
authors: TH
authors: Edna
authors: T
authors: T
authors: Bjerkeset
mesh_terms: D015998:Abbreviated Injury Scale; D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001803:Blood Transfusion / Q000706:statistics & numerical data; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007239:Infections / Q000453:epidemiology* / Q000209:etiology; D007902:Length of Stay / Q000706:statistics & numerical data; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D065227:Transfusion Reaction; D014947:Wounds and Injuries / Q000150:complications* / Q000175:diagnosis / Q000628:therapy