Effect of brovincamine on cerebral circulation and metabolism in internal carotid artery occlusion examined by positron emission tomography.
We evaluated the effect of brovincamine on the circulatory and metabolic state in the brain ischemia with internal carotid artery occlusion accompanying the 'misery perfusion syndrome'. Cerebral blood flow (CBF), cerebral metabolic rate of oxygen (CMRO2) and oxygen extraction fraction (OEF) were measured by PET before and after intravenous loading of brovincamine. Brovincamine increased CBF and decreased OEF significantly on the occluded side of the hemisphere. CMRO2 did not show any remarkable changes upon brovincamine administration. It was concluded that brovincamine might be useful for increasing the hemodynamic reserve, but did not affect the metabolic state immediately after its administration.
Yamaguchi
S
S
Department of Neurology, Faculty of Medicine, Kyoto University, Japan.
Fukuyama
H
H
Yonekura
Y
Y
Konishi
J
J
D000368:Aged; D001783:Blood Flow Velocity / Q000187:drug effects; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging / Q000187:drug effects; D016893:Carotid Stenosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002540:Cerebral Cortex / Q000098:blood supply / Q000000981:diagnostic imaging; D002544:Cerebral Infarction / Q000000981:diagnostic imaging / Q000188:drug therapy*; D004292:Dominance, Cerebral / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects; D014055:Tomography, Emission-Computed; D014749:Vincamine / Q000031:analogs & derivatives* / Q000627:therapeutic use
D014749:Vincamine; C033581:11-bromovincamine