title: A strategy to improve the efficacy of vaccination against tuberculosis and leprosy.
abstract: The pathogens responsible for leprosy, tuberculosis and the leishmaniases can induce different classes of immunity, but protection is provided only by a cell-mediated response. Here, Peter Bretscher proposes a strategy to achieve an immunological imprint that ensures a stable cell-mediated response upon natural infection.
authors: Dept of Microbiology, University of Saskatchewan, Saskatoon, Canada.
authors: P A
authors: PA
authors: Bretscher
mesh_terms: D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage* / Q000276:immunology; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology; D004198:Disease Susceptibility / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D020022:Genetic Predisposition to Disease; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular; D007113:Immunity, Innate / Q000235:genetics / Q000276:immunology; D007895:Leishmania tropica / Q000276:immunology; D016773:Leishmaniasis, Cutaneous / Q000276:immunology / Q000469:parasitology; D007918:Leprosy / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology / Q000469:parasitology; D009163:Mycobacterium bovis / Q000145:classification / Q000276:immunology; D009166:Mycobacterium leprae / Q000276:immunology*; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D051381:Rats; D014376:Tuberculosis / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D014611:Vaccination
chemical_list: D001500:BCG Vaccine; D001428:Bacterial Vaccines