GM-CSF, IL-3 and IL-5: cross-competition on human haemopoietic cells.
The biological properties of GM-CSF, IL-3 and IL-5 are multiple; initially described as haemopoietic growth factors, they also regulate inflammation, allergic reactions and cell adherence. The receptors for these three cytokines share a common component which may play a key role in their biological activity. This review describes the potential roles of GM-CSF, IL-3 and IL-5 in inflammation and discusses approaches to modulate their function.
Lopez
A F
AF
Hanson Centre for Cancer Research, Institute of Medical & Veterinary Science, Adelaide, Australia.
Elliott
M J
MJ
Woodcock
J
J
Vadas
M A
MA
D001667:Binding, Competitive; D002462:Cell Membrane / Q000378:metabolism; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000502:physiology*; D006410:Hematopoiesis; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D007377:Interleukin-3 / Q000502:physiology*; D015848:Interleukin-5 / Q000502:physiology*; D007962:Leukocytes / Q000502:physiology*; D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / Q000502:physiology*; D011971:Receptors, Immunologic / Q000502:physiology*; D018123:Receptors, Interleukin; D016185:Receptors, Interleukin-3 / Q000502:physiology*; D053649:Receptors, Interleukin-5; D015398:Signal Transduction
D007377:Interleukin-3; D015848:Interleukin-5; D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; D011971:Receptors, Immunologic; D018123:Receptors, Interleukin; D016185:Receptors, Interleukin-3; D053649:Receptors, Interleukin-5; D016178:Granulocyte-Macrophage Colony-Stimulating Factor