Encapsulated filtering bleb. A selective review--new deductions.
Filtering bleb encapsulation may, in some cases, be a severe complication following filtering surgery. The cause and mechanism of its development are not known. A selective review of data that might shed some light on these dilemmas, is presented. Based on these data, it is suggested that: (a) non-contractile collagen-producing fibroblasts play a major role in the process of bleb encapsulation, while in wound healing following filtering surgery, contractile fibroblasts are the major components; (b) the process of bleb encapsulation is less sensitive to the toxic effect of 5-Fluorouracil than would healing; (c) collagen-producing fibroblasts may be less sensitive to the destructive effect of 5-Fluorouracil than contractile fibroblasts; (d) inflammatory mediators are important triggers of bleb encapsulation.
Ophir
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Department of Ophthalmology, Hadassah University Hospital, Jerusalem, Israel.
D000818:Animals; D001768:Blister / Q000209:etiology* / Q000517:prevention & control; D002921:Cicatrix / Q000209:etiology* / Q000517:prevention & control; D003229:Conjunctival Diseases / Q000209:etiology* / Q000517:prevention & control; D005347:Fibroblasts / Q000473:pathology; D005472:Fluorouracil / Q000627:therapeutic use; D005901:Glaucoma / Q000601:surgery*; D006801:Humans; D011183:Postoperative Complications / Q000517:prevention & control; D011817:Rabbits; D014130:Trabeculectomy; D014529:Uridine / Q000031:analogs & derivatives / Q000627:therapeutic use; D014945:Wound Healing
C001943:5-fluorouridine; D005472:Fluorouracil; D014529:Uridine