[Endogenous levels and dynamics of estrogen sulfates--physiological and pathological roles of estrone sulfate and estradiol 17-sulfate].
Plasma ethinylestradiol increases 47.6% when taken with ascorbic acid because of competition in producing sulfate conjugation. Thus the role of sulfates may be important. Serum and urinary estrone sulfate (E1-S) in pregnancy and non-pregnancy were analyzed. Its serum peak during the menstrual cycle was 2.67 +/- 0.37 ng/ml (mean +/- SE) and about ten times that of estradiol-17 beta. E1-S showed lower levels in malignant tissues of breast cancer and endometrial cancer. Increased sulfatase activity in the malignant tissue hydrolyzes E1-S to E1, which may develop the tumors. Serum estradiol 17-sulfate (E2-17-S) in pregnancy was first measured. As E2-17-S decreased, lipid peroxides increased. E2-17-S is converted to 2-OH or 4-OH E2-17-S, which act as lipid peroxide scavengers. Pregnancy-induced hypertension showed lower levels of E2-17-S. In vitro study using the human endothelial cell of the aorta, E2-17-S and 2-OH E2-17-S strongly suppressed lipid peroxidation, which precedes atherosclerotic change.
Honjo
H
H
Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001161:Arteriosclerosis / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism; D004958:Estradiol / Q000031:analogs & derivatives* / Q000378:metabolism / Q000502:physiology; D004970:Estrone / Q000031:analogs & derivatives* / Q000378:metabolism / Q000502:physiology; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008597:Menstrual Cycle / Q000097:blood; D008875:Middle Aged; D011225:Pre-Eclampsia / Q000378:metabolism; D011247:Pregnancy / Q000097:blood; D014594:Uterine Neoplasms / Q000378:metabolism
D004970:Estrone; C048615:estradiol 17-sulfate; D004958:Estradiol; C017296:estrone sulfate