The producer and biological activities of SO-75R1, a new mutactimycin group antibiotic [corrected].
The producer of SO-75R1, a new anthracycline group antibiotic was identified as Nocardia brasiliensis. SO-75R1 was active against Gram-positive bacteria, but not active against Gram-negative bacteria or fungi. All tested Nocardia brasiliensis strains as well as the producer itself were resistant to SO-75R1, although four other pathogenic Nocardia, i.e. N. asteroides, N. nova, N. farcinica and N. otitidiscaviarum were sensitive [corrected].
Maeda
A
A
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
Yazawa
K
K
Mikami
Y
Y
Ishibashi
M
M
Kobayashi
J
J
D000818:Animals; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D007939:Leukemia L1210 / Q000188:drug therapy; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D008828:Microbiological Techniques; D009615:Nocardia / Q000737:chemistry*; D014407:Tumor Cells, Cultured; D014709:Vero Cells / Q000187:drug effects
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; C076088:SO 75R1