[Sequential parenteral and oral therapy with ofloxacin in urogenital infections].
125 hospitalized patients (56 men and 69 women) suffering from urinary tract infection (UTI) and 15 women with endometritis or pelvic inflammatory disease were treated with ofloxacin 6 mg/kg/d i.v. divided into 2 doses. Two thirds of the patients were switched to oral ofloxacin using the same dose regimen after 4 days. The median duration of treatment was 10 days. 98 patients were evaluable for efficacy: 45 had complicated lower UTI, 32 had upper UTI (75% of them with complications), 13 had endometritis and 8 an uncomplicated lower UTI. The most frequent complications of UTI were: obstruction (n = 27), indwelling catheters (n = 23), urinary concrements (n = 12), residual urine (n = 8) and a neurogenic bladder (n = 6). 22 patients had diabetes mellitus. A total of 103 pathogens was isolated from the urine of 85 patients, the most frequent being E. coli, Proteus spp. and Enterococcus faecalis. 98% of patients with UTI and 85% of patients with endometritis were clinically cured. Adverse drug events were observed in 6 patients.
Presterl
E
E
Klinischen Abteilung für Infektionen und Chemotherapie, Universitätsklinik für Innere Medizin I, Wien.
Bognar
H
H
Winkler
S
S
Thalhammer
F
F
Georgopoulos
A
A
Hoffmann
W
W
Breyer
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy* / Q000209:etiology; D004716:Endometritis / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D000292:Pelvic Inflammatory Disease / Q000188:drug therapy* / Q000209:etiology; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000209:etiology
Sequentielle parenterale und orale Therapie mit Ofloxacin bei urogenitalen Infektionen.