title: Immune reactivity in aging-autologous mixed lymphocyte responses.
abstract: The level of activity in the autologous mixed lymphocyte reaction (AMLR) was studied in populations of young and old subjects. AMLR activity was reduced in the older age group. A subpopulation of the older age group who had Alzheimer's disease was shown to have the lowest AMLR values. Within this group, those with a history indicating a more rapid development of CNS-related disability from senescence showed the weakest AMLR responses. The AMLR values correlated neither with sex, nutritional status nor history of infections. This impairment of a central regulating immune reaction may be a significant variable in manifestations of the aging process.
authors: McGill University School of Medicine, Thorp Laboratories of Clinical Immunology, Royal Victoria Hospital, Montreal, Que., Canada.
authors: C K
authors: CK
authors: Osterland
authors: E A
authors: EA
authors: St Louis
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000276:immunology*; D000544:Alzheimer Disease / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D006681:HLA-D Antigens; D006801:Humans; D007108:Immune Tolerance; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D006681:HLA-D Antigens