Omeprazole-like compounds on histamine-stimulated acid and peptic secretions in conscious dog and cat.
A newly synthetized aniline derivative series has been tested on histamine-stimulated gastric acid secretion in conscious cats and dogs and compared to the proton pump inhibitors omeprazole and NC 1300. The compounds markedly and long-lastingly inhibited acid output with a potency lower than omeprazole but very close to the reference compound NC 1300. The results show that the introduction of a nitrogen atom, irrespective of the position in the benzimidazole ring does not seem to influence the gastric antisecretory activity.
Chiavarini
M
M
Institute of Pharmacology and Pharmacognosy, Faculty of Pharmacy, University of Parma.
Barocelli
E
E
Ballabeni
V
V
Razzetti
R
R
Impicciatore
M
M
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D002415:Cats; D003243:Consciousness; D003864:Depression, Chemical; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004333:Drug Administration Routes; D004386:Duodenum / Q000187:drug effects* / Q000378:metabolism; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology; D015394:Molecular Structure; D009853:Omeprazole / Q000494:pharmacology*; D010434:Pepsin A / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects; D013329:Structure-Activity Relationship
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D001562:Benzimidazoles; C048733:2-((2-dimethylaminobenzyl)sulfinyl)benzimidazole; D006632:Histamine; D010434:Pepsin A; D009853:Omeprazole