[Estimation of pulmonary vascular permeability by indocyanine green in permeability pulmonary edema].
In this study we attempted to estimate pulmonary vascular permeability by indocyanine green (ICG). Permeability pulmonary edema was produced in 9 adult dogs by injecting 0.08 ml/kg oleic acid. We injected 50 mg ICG intravenously in 18 dogs (9 dogs with pulmonary edema and 9 control dogs). We measured the time course of ICG concentrations in pulmonary arterial blood, ICG concentration of peripheral lung tissue, tissue/serum ICG concentration ratios, and wet/dry lung weight ratios. The following results were obtained. The time course of ICG concentration in pulmonary arterial blood showed peak values at 2 minutes and became constant at 5 or 10 minutes after injection. The ICG concentration in peripheral lung tissue, tissue/serum ICG concentration ratios, and wet/dry lung weight ratios in the pulmonary edema group were significantly higher than those in the normal group. There was a strong linear correlation between wet/dry lung weight ratio and ICG concentration in peripheral lung tissue, with correlation coefficients of r = 0.936 (p < 0.01) in the right lung and r = 0.901 (p < 0.01) in the left lung. From these results, we conclude that estimation of pulmonary vascular permeability by ICG is a useful method.
Kato
S
S
First Department of Internal Medicine, Dokkyo University School of Medicine, Tochigi, Japan.
Asai
T
T
Ono
K
K
Onuma
N
N
Nakamoto
T
T
Iizuka
M
M
D000818:Animals; D002199:Capillary Permeability; D004285:Dogs; D007208:Indocyanine Green; D011651:Pulmonary Artery / Q000503:physiopathology*; D011652:Pulmonary Circulation; D011654:Pulmonary Edema / Q000175:diagnosis* / Q000503:physiopathology
D007208:Indocyanine Green