[Enzymes involved in metabolic activation of carcinogenic chemicals and their hormonal regulation].
Mechanisms of metabolic activation of carcinogenic chemicals, especially arylamines, are discussed together with characteristics of enzymes involved in the activation in the liver and extrahepatic tissues. In rodents, drug and carcinogen metabolizing activities often show clear age- and sex-related differences and also vary in diseased states. The current understanding of the roles of pituitary growth hormone and thyroid hormone on changes of hepatic drug metabolizing enzymes is shown in relation to the developmental changes and alteration in patho-physiological conditions.
Yamazoe
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Y
Department of Pharmacology, School of Medicine, Keio University, Tokyo, Japan.
D000123:Acetyltransferases / Q000378:metabolism; D000367:Age Factors; D000588:Amines / Q000493:pharmacokinetics*; D000818:Animals; D002273:Carcinogens / Q000493:pharmacokinetics*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D013006:Growth Hormone / Q000502:physiology; D006801:Humans; D008658:Inactivation, Metabolic; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D012727:Sex Characteristics; D015238:Sulfotransferases / Q000378:metabolism; D013963:Thyroid Hormones / Q000502:physiology*
D000588:Amines; D002273:Carcinogens; D013963:Thyroid Hormones; D013006:Growth Hormone; D003577:Cytochrome P-450 Enzyme System; D000123:Acetyltransferases; D015238:Sulfotransferases