[Effects of dehydroepiandrosterone sulfate on the uterus and estrogen receptors in rats].
Dehydroepiandrosterone sulfate (DHA-S) at dosages of 50, 100 and 200 mg/kg s.c. for 3 days was shown to have obvious promotive effects on the growth of the uterus in immature rats. However, DHA-S given to ovariectomized rats at 40 and 100 mg/kg for 5 days was found to have no effect on the uterus. Incubation of granulosa cells for 3 h with DHA-S caused a significant increase in estradiol secretion. Even though DHA-S was found to increase uterine estrogen receptor concentration, this compound was shown to have no affinity for the estrogen receptor. It appears that the effects of DHA-S resulted mainly from the activity of its metabolite--estrogen.
Wang
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N
Institute of Materia Medica, Beijing.
D000818:Animals; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D019314:Dehydroepiandrosterone Sulfate; D004958:Estradiol / Q000378:metabolism; D005260:Female; D006107:Granulosa Cells / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D011960:Receptors, Estrogen / Q000187:drug effects*; D014599:Uterus / Q000033:anatomy & histology / Q000187:drug effects*
D011960:Receptors, Estrogen; D003687:Dehydroepiandrosterone; D004958:Estradiol; D019314:Dehydroepiandrosterone Sulfate