title: An ocular dynamic study supporting the hypothesis that hypothyroidism is a treatable cause of secondary open-angle glaucoma.
abstract: To examine the hypothesis that glaucoma may be a manifestation of unrecognized hypothyroidism, we studied 25 consecutive patients with newly diagnosed hypothyroidism who presented to an endocrinology clinic. Using tonography and tonometry, we demonstrated a reduction in facility of outflow in the hypothyroid state. With treatment of the hypothyroidism alone there was a statistically significant improvement in facility of outflow, intraocular pressure and Po/C (p < 0.002). Our results support the hypothesis that secondary open-angle glaucoma may be a manifestation of hypothyroidism and that the glaucoma will resolve on treatment of the primary disease.
authors: Department of Ophthalmology, University of Western Ontario, London.
authors: K D
authors: KD
authors: Smith
authors: G J
authors: GJ
authors: Tevaarwerk
authors: L H
authors: LH
authors: Allen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005902:Glaucoma, Open-Angle / Q000209:etiology* / Q000628:therapy; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000188:drug therapy*; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000627:therapeutic use*; D014065:Tonometry, Ocular
chemical_list: D013972:Thyrotropin; D013974:Thyroxine