A strategy to improve the efficacy of vaccination against tuberculosis and leprosy.
The pathogens responsible for leprosy, tuberculosis and the leishmaniases can induce different classes of immunity, but protection is provided only by a cell-mediated response. Here, Peter Bretscher proposes a strategy to achieve an immunological imprint that ensures a stable cell-mediated response upon natural infection.
Bretscher
P A
PA
Dept of Microbiology, University of Saskatchewan, Saskatoon, Canada.
D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage* / Q000276:immunology; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology; D004198:Disease Susceptibility / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D020022:Genetic Predisposition to Disease; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular; D007113:Immunity, Innate / Q000235:genetics / Q000276:immunology; D007895:Leishmania tropica / Q000276:immunology; D016773:Leishmaniasis, Cutaneous / Q000276:immunology / Q000469:parasitology; D007918:Leprosy / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology / Q000469:parasitology; D009163:Mycobacterium bovis / Q000145:classification / Q000276:immunology; D009166:Mycobacterium leprae / Q000276:immunology*; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D051381:Rats; D014376:Tuberculosis / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D014611:Vaccination
D001500:BCG Vaccine; D001428:Bacterial Vaccines