title: A study on the viscoelastic properties of the urinary bladder in dogs.
abstract: This experimental study was designed and carried out in order to investigate the participation of the collagen and muscular tissues on the viscoelastic properties of the bladder wall. Sixty-five adult male mongrel dogs were utilized. These animals were divided into 5 groups: control group (n = 10); dogs (n = 10) receiving 2.5 mg/kg atropine (cholinergic antagonist); dogs (n = 10) receiving 0.7 mg/kg verapamil (calcium extracellular inflow blocker); dogs (n = 10) receiving 0.1 mg/kg/min nitroprusside (intracellular calcium blocker), and dogs (n = 25) receiving EGTA (a calcium-chelating agent) at increasing doses from 90 to 450 mg/kg. Based on a mathematical model, we have demonstrated that: (1) the collagen component is responsible for the elastic properties; (2) the muscle component is responsible for the viscoelastic properties; (3) the viscoelastic properties have an active element which is affected by calcium total depletion, and (4) such viscoelastic properties are not dependent on cholinergic stimulation.
authors: Department of Urology, San Carlos Hospital Medical School, Complutense University, Madrid, Spain.
authors: J
authors: J
authors: Salinas
authors: M
authors: M
authors: Virseda
authors: M P
authors: MP
authors: Fuente
authors: F
authors: F
authors: Mellado
authors: A C
authors: AC
authors: Uson
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001696:Biomechanical Phenomena; D004285:Dogs; D004533:Egtazic Acid / Q000008:administration & dosage; D004547:Elastic Tissue / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008954:Models, Biological; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D009599:Nitroprusside / Q000008:administration & dosage; D011897:Random Allocation; D001743:Urinary Bladder / Q000187:drug effects / Q000502:physiology*; D014700:Verapamil / Q000494:pharmacology
chemical_list: D009599:Nitroprusside; D004533:Egtazic Acid; D001285:Atropine; D014700:Verapamil