Interrelationship between lactate and cardiac fatty acid metabolism.
This overview is presented, in the main, to summarize the following aspects of lactate and cardiac fatty acid metabolism: 1. The utilization of exogenous carbohydrates and fatty acids by the heart. 2. The competition between lactate and fatty acids in cardiac energy metabolism. 3. The effect of lactate on endogenous triacylglycerol homeostasis. 4. Lactate-induced impairment of functional recovery of the post-ischemic heart. 5. The effect of lactate on lipid metabolism in the ischemic and post-ischemic heart. 6. The consequences of hyperlactaemia for cardiac imaging.
van der Vusse
G J
GJ
Department of Physiology, University of Limburg, Maastricht, The Netherlands.
de Groot
M J
MJ
D000818:Animals; D050260:Carbohydrate Metabolism; D004285:Dogs; D004734:Energy Metabolism; D005227:Fatty Acids / Q000378:metabolism*; D006321:Heart / Q000000981:diagnostic imaging; D006706:Homeostasis; D006801:Humans; D007773:Lactates / Q000378:metabolism*; D019344:Lactic Acid; D017202:Myocardial Ischemia / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D011877:Radionuclide Imaging; D051381:Rats; D013552:Swine; D014280:Triglycerides / Q000378:metabolism
D005227:Fatty Acids; D007773:Lactates; D014280:Triglycerides; D019344:Lactic Acid