title: Effect of cyclosporin on plasma lipoprotein lipase activity in rats.
abstract: The effects of cyclosporin on plasma lipoproteins and lipoprotein lipase (LPL) activity were studied in rats treated with different doses of the drug for periods ranging between 7 and 30 days. The treatment with cyclosporin resulted in an increase in plasma triglycerides and non-HDL-cholesterol, and a dose and time-dependent decrease of LPL activity and HDL-cholesterol, mainly because of a fall in the HDL2-cholesterol subfraction. The decrease of LPL activity was positively correlated (p < 0.01) with plasma HDL-cholesterol and HDL2-cholesterol and negatively with plasma triglycerides and non-HDL-cholesterol (p < 0.01). Our results indicate that the decrease in plasma LPL activity may be responsible for the increase in plasma triglycerides and the decrease in plasma HDL-cholesterol found in rats under cyclosporin treatment.
authors: Unidad de Lipidos y Arteriosclerosis, Hopital Universitario Reina Sofia, Cordoba, Spain.
authors: J
authors: J
authors: López-Miranda
authors: F
authors: F
authors: Pérez-Jiménez
authors: J A
authors: JA
authors: Gómez-Gerique
authors: A
authors: A
authors: Espino-Montoro
authors: L
authors: L
authors: Hidalgo-Rojas
authors: J
authors: J
authors: Pedreño
authors: J A
authors: JA
authors: Jiménez-Perepérez
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D016572:Cyclosporine / Q000008:administration & dosage / Q000494:pharmacology*; D008071:Lipoprotein Lipase / Q000097:blood*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D016572:Cyclosporine; D002784:Cholesterol; D008071:Lipoprotein Lipase