title: Limb anomalies following chorionic villus sampling: a registry based case-control study.
abstract: Using data from the Italian Multicentric Birth Defect Registry a case-control study was performed to verify if chorionic villus sampling (CVS) was associated with transverse limb defects (TLD), with or without features of oro-mandibular-limb hypogenesis complex (OMLHC), in the exposed offspring. The results show that the risk of TLD and OMLHC is increased following CVS, and is particularly high for CVS performed early in pregnancy, i.e., under 70 days of gestational age. These results, together with a review of other epidemiologic studies, biological data and clinical reports, strongly suggest a causative role of CVS as a risk factor for TLD and indicate that at this stage CVS before 70 days of gestational age should be discouraged as an option for prenatal diagnosis and that all patients wishing to undergo CVS should be informed about the possible risk of the procedure.
authors: Department of Pediatrics, Catholic University, Rome, Italy.
authors: P
authors: P
authors: Mastroiacovo
authors: L D
authors: LD
authors: Botto
authors: D P
authors: DP
authors: Cavalcanti
authors: F
authors: F
authors: Lalatta
authors: A
authors: A
authors: Selicorni
authors: A E
authors: AE
authors: Tozzi
authors: D
authors: D
authors: Baronciani
authors: A C
authors: AC
authors: Cigolotti
authors: S
authors: S
authors: Giordano
authors: F
authors: F
authors: Petroni
mesh_terms: D000015:Abnormalities, Multiple / Q000196:embryology / Q000453:epidemiology; D016022:Case-Control Studies; D015193:Chorionic Villi Sampling / Q000009:adverse effects*; D002869:Chromosome Aberrations / Q000196:embryology / Q000453:epidemiology; D025063:Chromosome Disorders; D015331:Cohort Studies; D000013:Congenital Abnormalities / Q000453:epidemiology / Q000209:etiology; D005121:Extremities / Q000196:embryology; D005260:Female; D005315:Fetal Diseases / Q000453:epidemiology / Q000209:etiology*; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D017880:Limb Deformities, Congenital; D008297:Male; D008334:Mandible / Q000002:abnormalities; D009056:Mouth Abnormalities / Q000196:embryology / Q000453:epidemiology; D011247:Pregnancy; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors