Acetylhomocysteine thiolactone protection against phosphamidon-induced alteration of regional superoxide dismutase activity in the central nervous system and its correlation with altered lipid peroxidation.
Phosphamidon intoxication (2 mg/kg body wt./day for 7 days) inhibited SOD activity, but enhanced the lipid peroxidation in various CNS regions. Administration of cithiolone (8 mg/kg body wt./day, ip for 7 days), however, elevated SOD activity and depleted lipid peroxidation. Interestingly, no significant change was observed either in SOD activity or in lipid peroxidation following simultaneous administration of phosphamidon and cithiolone.
Naqvi
S M
SM
Interdisciplinary Brain Research Centre, Jawaharlal Nehru Medical College, Aligarh Muslim University, India.
Hasan
M
M
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D010707:Phosphamidon / Q000037:antagonists & inhibitors* / Q000633:toxicity; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism; D013876:Thiophenes / Q000494:pharmacology*
D013876:Thiophenes; D010707:Phosphamidon; C000486:citiolone; D013482:Superoxide Dismutase