Growth and morphogenesis in Streptomyces.
In this report we propose a model of apical growth for streptomycetes. The apical tip is considered as a multilayered wall that expands by an inside-to-outside mechanism of growth. It is also assumed that each layer is made up of peptidoglycan blocks, each of them being the result of the biosynthetic activity of a wall-synthesizing unit or membrane-associated growth zone. According to our model, apical growth occurs as follows: as a consequence of the hydrostatic pressure and the cleavage of some bonds, the layers are pushed and forced to slide (one with respect to the other), migrating from the center of the tip (at the inside of the wall) towards a peripheral location (at the outside of the wall). The model also incorporates a mechanism by which apical growth can be regulated and coordinated with the replication of the chromosome.
Miguélez
E M
EM
Departamento de Biología Funcional, Facultad de Medicina, Universidad de Oviedo, Spain.
Martín
C
C
Manzanal
M B
MB
Hardisson
C
C
D002473:Cell Wall / Q000378:metabolism; D004269:DNA, Bacterial / Q000096:biosynthesis; D008954:Models, Biological; D010457:Peptidoglycan / Q000096:biosynthesis; D013302:Streptomyces / Q000254:growth & development* / Q000378:metabolism
D004269:DNA, Bacterial; D010457:Peptidoglycan