title: 7-Alkoxyquinoline O-dealkylation by microsomes from human liver and placenta.
abstract: 1. The O-dealkylation of seven 7-alkoxyquinoline derivatives by human hepatic and placental microsomes and the effect of maternal cigarette smoking on placental 7-alkoxyquinoline metabolism was studied. 2. None of several monoclonal antibodies to isoenzymes of cytochrome P450 had a clear effect on metabolism of the compounds by liver microsomes. 3. Maternal cigarette smoking induced the O-dealkylation of all of the 7-alkoxyquinoline derivatives, being greatest for 7-butoxy- and 7-benzyloxyquinoline. 4. Placental 7-alkoxyquinoline metabolism induced by smoking was partially inhibited by the monoclonal antibody 1-7-1 raised against 3-methylcholanthrene-induced rat liver P450. 5. None of the 7-alkoxyquinoline O-dealkylations could be assigned specifically to any known P450 isoenzyme in human liver or placenta.
authors: Department of Pharmacology and Toxicology, University of Oulu, Finland.
authors: J
authors: J
authors: Hakkola
authors: J
authors: J
authors: Mäenpää
authors: R T
authors: RT
authors: Mayer
authors: S S
authors: SS
authors: Park
authors: H V
authors: HV
authors: Gelboin
authors: O
authors: O
authors: Pelkonen
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D001593:Benzyl Compounds / Q000378:metabolism; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003640:Dealkylation; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008861:Microsomes / Q000201:enzymology / Q000378:metabolism*; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D010920:Placenta / Q000201:enzymology / Q000378:metabolism*; D011247:Pregnancy; D011804:Quinolines / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012907:Smoking / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D001593:Benzyl Compounds; D065607:Cytochrome P-450 Enzyme Inhibitors; D011804:Quinolines; D003577:Cytochrome P-450 Enzyme System