[Cytogenetic subtyping of 139 uterine leiomyoma].
A cytogenetic study of 139 uterine leiomyomas of 70 patients is presented. 26 of the tumours failed to grow, 87 showed an apparently normal karyotype and 26 tumours were characterised by clonal aberrations. In 5 tumours, a numerical change was the only abnormality, including 2 tumours with a trisomy 12. 5 myomas showed an interstitial deletion of the long arm of chromosome 7. The largest group were 9 tumours with an aberration involving chromosome 12 in the band of 14-15. 2 myomas showed a t(12; 14) as the only abnormality, in 4 tumours very complex rearrangements with up to 12 breakpoints were observed. In the last group 7 myomas with other clonal aberrations involving 11 different chromosomes were found.
Stern
C
C
Zentrum für Humangenetik und Genetische Beratung, Universität Bremen.
Deichert
U
U
Thode
B
B
Bartnitzke
S
S
Bullerdiek
J
J
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology; D002869:Chromosome Aberrations / Q000235:genetics*; D005260:Female; D007621:Karyotyping; D007889:Leiomyoma / Q000145:classification / Q000235:genetics* / Q000473:pathology; D014594:Uterine Neoplasms / Q000145:classification / Q000235:genetics* / Q000473:pathology; D014599:Uterus / Q000473:pathology
Eine zytogenetische Subtypisierung von 139 Uterus-Leiomyomen.