title: [The effect of vasoactive factors on the growth of of coronary endothelial cells].
abstract: The aim of this study was to evaluate the effect of adenosine and bradykinin on endothelial cell growth at capillary level. DNA synthesis was measured in subconfluent capillary endothelial cells obtained from coronary venules (CVEC) after exposure to adenosine or bradykinin. Our results indicate that adenosine and bradykinin induced a dose-dependent proliferation of CVEC. Maximal effect was observed at the dose 100 microM concentration for adenosine and 0.1 microM concentration for bradykinin.
authors: Dipartimento di Farmacologia, Università degli Studi, Firenze.
authors: M
authors: M
authors: Ziche
authors: A
authors: A
authors: Parenti
authors: L
authors: L
authors: Morbidelli
authors: C J
authors: CJ
authors: Meininger
authors: H J
authors: HJ
authors: Granger
authors: F
authors: F
authors: Ledda
mesh_terms: D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured / Q000166:cytology / Q000187:drug effects; D003331:Coronary Vessels / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000241:Adenosine; D001920:Bradykinin
vernacular_title: Effetto di fattori vasoattivi sulla crescita di cellule endoteliali coronariche.