Low platelet gamma-aminobutyrate aminotransferase and monoamine oxidase activities in chronic alcoholic patients.
The activities of gamma-aminobutyrate aminotransferase (GABA-T) and monoamine oxidase (MAO) were estimated in blood platelets from 25 male chronic alcoholics and from 27 healthy male volunteers without histories of alcohol abuse. Based on clinical criteria, the alcoholics were classified into type 1 or type 2 alcoholism. The activity of GABA-T was found to be lower both in type 1 and type 2 alcoholics than in healthy volunteers. With regard to MAO, the platelet activity was found to be significantly lower only in type 2 alcoholics in concordance with previous reports. No significant correlation was found between the activities of GABA-T and MAO in the blood platelets of healthy volunteers. The inhibitory effect of 400 mM ethanol on the platelet MAO activity increased with decreasing concentrations of the substrate phenylethylamine. The degree of inhibition of ethanol on the platelet MAO activity, however, did not differ significantly between alcoholics and controls.
Sherif
F
F
Department of Medical Pharmacology, Uppsala University, Sweden.
Hallman
J
J
Oreland
L
L
D000612:4-Aminobutyrate Transaminase / Q000097:blood*; D000328:Adult; D000437:Alcoholism / Q000145:classification / Q000201:enzymology* / Q000534:rehabilitation; D001792:Blood Platelets / Q000201:enzymology*; D002478:Cells, Cultured; D000431:Ethanol / Q000493:pharmacokinetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000201:enzymology; D008995:Monoamine Oxidase / Q000097:blood*; D011569:Psychiatric Status Rating Scales; D012016:Reference Values
D000431:Ethanol; D008995:Monoamine Oxidase; D000612:4-Aminobutyrate Transaminase