Failure of dietary restriction to retard age-related neurochemical changes in mice.
Age-sensitive neurochemical measures and estrous cyclicity were studied in female mice from the long-lived C3B10F1 strain fed either a control diet or subjected to dietary restriction (DR) from 3 weeks of age. Striatal dopaminergic D2 receptor density decreased by 25% from 9-10 months to 28-30 months of age in the control group. This decline was uninfluenced by DR. Anterior pituitary dopamine + dihydroxyphenylacetic acid content increased by 2.5 fold with age in the control group but DR failed to oppose this age-related change. In contrast to DR's lack of influence on these two neurochemical measures were findings on estrous cyclicity. Although mice on DR did not display estrous cycles, cyclicity was rapidly initiated when these mice were switched to the control diet at 12 and even at 22 months of age. Thus, limited aspects of neuroendocrine aging were retarded by DR in this long-lived mouse model.
May
P C
PC
Andrus Gerontology Center, University of Southern California, Los Angeles 90089-01091.
Telford
N
N
Salo
D
D
Anderson
C
C
Kohama
S G
SG
Finch
C E
CE
Walford
R L
RL
Weindruch
R
R
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001923:Brain Chemistry / Q000502:physiology*; D003342:Corpus Striatum / Q000378:metabolism; D004032:Diet; D004298:Dopamine / Q000378:metabolism; D004971:Estrus / Q000502:physiology; D005260:Female; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009419:Nerve Tissue Proteins / Q000378:metabolism; D010903:Pituitary Gland, Anterior / Q000378:metabolism; D017448:Receptors, Dopamine D2 / Q000378:metabolism
D009419:Nerve Tissue Proteins; D017448:Receptors, Dopamine D2; D004298:Dopamine