Chlorinated hydrocarbons in the bone marrow of children: studies on their association with leukaemia.
Concentrations of chlorinated hydrocarbons and polychlorinated biphenyls (PCB) were determined by capillary column gas chromatography in samples of bone marrow from 38 children with leukaemia (16 samples/pools) and 15 control (5 pools). The highest mean and median concentrations were detected for total PCB (mean = 3.568 mg/kg fat basis/median 2.904 mg/kg) followed by the sum of the dichlorodiphenyltrichloroethane metabolites (1.775/1.059 mg/kg), hexachlorobenzene 0.354/0.260 mg/kg), the sum of the hexachlorocyclohexane isomers (0.133/0.093 mg/kg) and dieldrin (0.109/0.063 mg/kg). The CHC and PCB concentrations in bone marrow were two- to threefold higher than in fat tissue. Comparing children with and without leukaemia similar concentrations of CHC and PCB were found.
Scheele
J
J
Children's Hospital Mannheim, University of Heidelberg, Federal Republic of Germany.
Teufel
M
M
Niessen
K H
KH
D001853:Bone Marrow / Q000737:chemistry*; D016022:Case-Control Studies; D002648:Child; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000032:analysis*; D015470:Leukemia, Myeloid, Acute; D010575:Pesticides / Q000032:analysis; D011078:Polychlorinated Biphenyls / Q000032:analysis*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma
D006843:Hydrocarbons, Chlorinated; D010575:Pesticides; D011078:Polychlorinated Biphenyls