title: Ciprofloxacin plus vancomycin versus ceftazidime plus gentamicin in the treatment of pneumonia in granulocytopenic patients with or without venous catheters. Short communication.
abstract: 58 granulocytopenic patients with confirmed bronchopneumonia were divided retrospectively into two groups for this pilot study: group 1 included neutropenic patients with venous catheters who were treated with ciprofloxacin (CIP; 200-300 mg, i.v. b.i.d.) + vancomycin (VAN; 0.5-1 g, i.v. b.i.d.), and group 2, which included patients without venous catheters treated with ceftazidime (2 g, i.v. t.i.d.) + gentamicin (1 mg/kg, i.v. t.i.d.). Pneumonia was diagnosed clinically and radiologically in all patients; 92.3% in group 1 and 46.8% in group 2 were also microbially confirmed. Mixed infections were present in most patients. 3 of 26 patients (11.5%) in group 1 and 9 of 32 (20.1%) in group 2 did not recover while 88.5% in group 1 and 71.9% in group 2 recovered. CIP + VAN seems to be more effective in treating pneumonia in neutropenic patients, with only 1 patient in the group suffering an adverse effect compared with 5 in group 2.
authors: Department of Clinical Oncology, Postgraduate Medical School, Bratislava, CSFR.
authors: V
authors: V
authors: Krcméry
authors: P
authors: P
authors: Fuchsberger
authors: J
authors: J
authors: Trupl
authors: J
authors: J
authors: Sufliarsky
authors: S
authors: S
authors: Spanik
authors: I
authors: I
authors: Koza
authors: Z
authors: Z
authors: Kusenda
authors: S
authors: S
authors: Korec
authors: J
authors: J
authors: Svec
authors: P
authors: P
authors: Durkovic
mesh_terms: D000328:Adult; D000380:Agranulocytosis / Q000150:complications*; D001996:Bronchopneumonia / Q000188:drug therapy*; D002404:Catheterization; D002442:Ceftazidime / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D005839:Gentamicins / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D010865:Pilot Projects; D014640:Vancomycin / Q000627:therapeutic use
chemical_list: D005839:Gentamicins; D002939:Ciprofloxacin; D014640:Vancomycin; D002442:Ceftazidime