Study of chronic schizophrenics using 31P magnetic resonance chemical shift imaging.
Phosphorus-31 chemical shift imaging showed regional abnormalities of in vivo 31P NMR spectra in the brains of chronic schizophrenic patients. In the left temporal region, the level of % phosphodiesters (PDE) was increased and the level of % gamma alpha beta-ATP (obtained by summation of gamma-ATP, alpha-ATP, and beta-ATP) was decreased. In the basal ganglia, the levels of % PDE were decreased and the level of % phosphomonoesters was increased. The levels of % gamma alpha beta-ATP were increased in the right basal ganglia. The level of % phosphocreatine was decreased in the frontoparietal region. These findings may represent different patterns of dysfunction of membrane phospholipid bilayers and high-energy phosphate metabolism in the specific cerebral regions.
Fujimoto
T
T
Department of Psychiatry, South Japan Health Science Centre, Fujimoto Hospital.
Nakano
T
T
Takano
T
T
Hokazono
Y
Y
Asakura
T
T
Tsuji
T
T
D000255:Adenosine Triphosphate / Q000378:metabolism; D001479:Basal Ganglia / Q000503:physiopathology; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology; D002908:Chronic Disease; D003337:Corpus Callosum / Q000503:physiopathology; D004292:Dominance, Cerebral / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008563:Membrane Lipids / Q000378:metabolism; D019965:Neurocognitive Disorders / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D010710:Phosphates / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D011569:Psychiatric Status Rating Scales; D012016:Reference Values; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*; D012565:Schizophrenic Psychology
D008563:Membrane Lipids; D010710:Phosphates; D010743:Phospholipids; D000255:Adenosine Triphosphate