title: Preparation and diuretic properties of novel amiloride analogues.
abstract: Fifteen novel amiloride analogues were synthesized and their diuretic properties compared to amiloride and triamterene in white wistar rats. Whereas none of the 6-substituted derivatives exhibited significant natriuretic and antikaliuretic effects, five of the compounds modified in the 2-position were found equal or better than standards. The results are discussed with respect to chemical structure and physiochemical properties.
authors: Institut für Organische Chemie, Universität Frankfurt am Main, Germany.
authors: T
authors: T
authors: Russ
authors: W
authors: W
authors: Ried
authors: F
authors: F
authors: Ullrich
authors: E
authors: E
authors: Mutschler
mesh_terms: D000584:Amiloride / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004232:Diuretics / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004232:Diuretics; D000584:Amiloride