Confirmation of centromeric fusion in 7p/1q translocation associated with myelodysplastic syndrome.
Fluorescence in situ hybridization (FISH) using chromosome 1- and chromosome 7-specific centromeric alpha-satellite probes was performed on the bone marrow (BM) cells of a patient with myelodysplastic syndrome (MDS) who had been treated for lymphoma and whose BM karyotype was initially considered to be 46,XY,-7,+der(1)t(1;7)(p11;p11). FISH results suggested the presence of both chromosome 1 and chromosome 7 centromeres in the rearranged chromosome. Thus, the correct karyotype should be written as 46,XY,-7,+der(1;7)(q10;p10).
Hoo
J J
JJ
Office of Consolidated Laboratory Services, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612.
Szego
K
K
Jones
B
B
D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D002503:Centromere; D002878:Chromosomes, Human, Pair 1; D002897:Chromosomes, Human, Pair 7; D015342:DNA Probes; D004276:DNA, Satellite; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008223:Lymphoma / Q000150:complications / Q000628:therapy; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000235:genetics*; D014178:Translocation, Genetic
D015342:DNA Probes; D004276:DNA, Satellite