Penetration of vancomycin in uninfected sternal bone.
Concentrations of vancomycin in sternal bones of 10 patients undergoing cardiac surgery were studied at steady state, 48 h after starting intravenous prophylaxis. A sample of sternal bone was taken before (group I) or after (group II) cardiopulmonary bypass. The mean vancomycin concentrations in sternal bones were not significantly different between the groups and were 9.3 +/- 3.0 micrograms/g. The concentrations of vancomycin in sternal bones were always above the MICs for staphylococci, streptococci, and enterococci.
Massias
L
L
Service de Pharmacie Clinique et des Biomatériaux, CHU Xavier Bichat-Claude Bernard, Paris, France.
Dubois
C
C
de Lentdecker
P
P
Brodaty
O
O
Fischler
M
M
Farinotti
R
R
D000328:Adult; D001847:Bone Diseases / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism*; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D004058:Diffusion; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011292:Premedication; D013203:Staphylococcal Infections / Q000517:prevention & control; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013249:Sternum; D014640:Vancomycin / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use
D014640:Vancomycin