A prospective, randomised, cross-over study comparing the effects of clomiphene citrate and cyclofenil on endometrial morphology in the luteal phase of normal, fertile women.
OBJECTIVE
To examine the effect of two anti-oestrogens, clomiphene citrate and cyclofenil, on endometrial morphology in the luteal phase.


METHODS
A prospective, randomised, cross-over study.


METHODS
Jessop Hospital for Women, Sheffield, UK.


METHODS
10 women who were previously fertile and regularly cycling.


METHODS
The administration of clomiphene citrate or cyclofenil in the treatment cycles. A LH timed endometrial biopsy was taken on day LH + 6.


METHODS
Histological dating and morphometric analysis of the endometrial sample.


RESULTS
Only one out of 10 subjects had abnormal endometrium. There was no difference in the results between cycles treated with clomiphene citrate and cyclofenil.


CONCLUSIONS
Clomiphene citrate or cyclofenil does not have a major adverse effect on endometrial morphology in the luteal phase of normal fertile subjects. The possible adverse effects of anti-oestrogens on endometrium may have been previously overestimated.
Li
T C
TC
Department of Obstetrics and Gynaecology, Jessop Hospital for Women, Sheffield, UK.
Warren
M A
MA
Murphy
C
C
Sargeant
S
S
Cooke
I D
ID
D000328:Adult; D002996:Clomiphene / Q000008:administration & dosage / Q000494:pharmacology*; D003506:Cyclofenil / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004717:Endometrium / Q000187:drug effects*; D005260:Female; D006801:Humans; D008183:Luteal Phase / Q000187:drug effects*; D011446:Prospective Studies
D002996:Clomiphene; D003506:Cyclofenil