Correlation of splenic function with the splenic uptake rate of Tc-colloids.
The splenic uptake rate of Tc-sulphur colloid or Tc-tin colloid was measured and found to correlate well with splenic function. The normal tracer uptake rate was 0.0002/s-0.0006/s (measured uptake rate divided by measured injected activity). Lower values indicated hyposplenism (sensitivity = 0.97, specificity = 0.95), and values over 0.0006/s indicated hypersplenism (sensitivity = 0.96, specificity = 0.97). Higher values of splenic uptake were associated with proportional reductions in the white blood cell and platelet counts, and to a lesser extent the haemoglobin concentration in peripheral blood. Patients with rheumatoid arthritis had increased tracer uptake, but still below the criteria for hypersplenism, whereas patients with Felty's syndrome had tracer uptake rates in the 'hypersplenic' range.
Rutland
M D
MD
Auckland Hospital, New Zealand.
D006801:Humans; D006971:Hypersplenism / Q000000981:diagnostic imaging / Q000378:metabolism; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D013158:Splenic Diseases / Q000000981:diagnostic imaging / Q000378:metabolism*; D013667:Technetium / Q000493:pharmacokinetics*; D017556:Technetium Compounds; D013671:Technetium Tc 99m Sulfur Colloid / Q000493:pharmacokinetics*; D014001:Tin / Q000493:pharmacokinetics*; D017971:Tin Compounds
D017556:Technetium Compounds; D017971:Tin Compounds; C033493:technetium Tc 99m tin colloid; D013671:Technetium Tc 99m Sulfur Colloid; D013667:Technetium; D014001:Tin