title: The effect of paracetamol or diclofenac administered before operation on postoperative pain and behaviour after adenoidectomy in small children.
abstract: We compared the effects of rectally administered diclofenac (12.5 mg) with paracetamol (125 mg) on pre- and postoperative behaviour and the need for supplementary analgesia in 44 children scheduled for adenoidectomy (with or without myringotomy). The study drugs were given in combination with diazepam (0.5 mg.kg-1) about 20 min before the children were taken to the operating theatre. On arrival there, the children who had received diclofenac were significantly quieter (< 0.05), easier to handle (p < 0.01) and cried less (p < 0.05) than those in the paracetamol group. During recovery, children in the diclofenac group needed fewer supplementary doses of intravenous pethidine than those receiving paracetamol (p < 0.001). There were no obvious differences between the groups in intra-operative bleeding (as estimated by the surgeon), or in measured blood loss. No postoperative complications became evident. The pre-operative rectal administration of diclofenac for pain relief after adenotomy is safe and effective.
authors: Department of Anaesthesiology, Tampere University Hospital, Finland.
authors: G A
authors: GA
authors: Baer
authors: M G
authors: MG
authors: Rorarius
authors: S
authors: S
authors: Kolehmainen
authors: S
authors: S
authors: Selin
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage*; D000233:Adenoidectomy; D000285:Administration, Rectal; D002652:Child Behavior / Q000187:drug effects; D002675:Child, Preschool; D003448:Crying; D004008:Diclofenac / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D010149:Postoperative Pain / Q000517:prevention & control*; D011292:Premedication; D011595:Psychomotor Agitation / Q000517:prevention & control
chemical_list: D004008:Diclofenac; D000082:Acetaminophen