title: Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR.
abstract: The human dopamine transporter (DAT1) gene is localized to chromosome 5p15.3 by in situ hybridization and PCR amplification of rodent somatic cell hybrid DNA. Analysis of a 40-bp repeat in the 3' untranslated region of the message revealed variable numbers of the repeat ranging from 3 to 11 copies. These results will aid in the investigation of a role for this gene in genetic disorders of the dopaminergic system in humans.
authors: Laboratory of Molecular Neurobiology, National Institute on Drug Abuse, Baltimore, MD 21224.
authors: D J
authors: DJ
authors: Vandenbergh
authors: A M
authors: AM
authors: Persico
authors: A L
authors: AL
authors: Hawkins
authors: C A
authors: CA
authors: Griffin
authors: X
authors: X
authors: Li
authors: E W
authors: EW
authors: Jabs
authors: G R
authors: GR
authors: Uhl
mesh_terms: D000818:Animals; D001345:Autoradiography; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D002884:Chromosomes, Human, Pair 15; D004247:DNA / Q000235:genetics; D050483:Dopamine Plasma Membrane Transport Proteins; D006801:Humans; D006822:Hybrid Cells; D017403:In Situ Hybridization; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins; D012091:Repetitive Sequences, Nucleic Acid; D012377:Rodentia
chemical_list: D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493214:SLC6A3 protein, human; D004247:DNA