Ethylcellulose as a carrier for controlled-release acetaminophen tablets.
In this study ethylcellulose was evaluated as a carrier for preparation of prolonged release acetaminophen tablets. Solid dispersions containing three levels of ethylcellulose and acetaminophen (1:3; 1:1; 3:1) were prepared by the solvent method. Also physical mixtures at the same level of ethylcellulose and acetaminophen were prepared. Systems composed of solid dispersion or physical mixture containing the equivalent weight of 50 mg acetaminophen, Emcompress as diluent and 1% magnesium stearate as lubricant were compressed into tablets and tested for dissolution. The dissolution data showed that the drug release decreased as the level of ethylcellulose increased in the solid dispersion formulations. The drug release from tablets prepared with solid dispersion followed the diffusion controlled model for inert porous matrix, while the drug release from tablets prepared with physical mixture followed the first-order kinetic model.
Ghaly
E S
ES
School of Pharmacy, Medical Sciences Campus, University of Puerto Rico, San Juan 00936.
Hernández
J I
JI
Malavé
A
A
Marti
A
A
D000082:Acetaminophen / Q000008:administration & dosage* / Q000378:metabolism; D002482:Cellulose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers; D004339:Drug Compounding; D006801:Humans
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D000082:Acetaminophen; C013517:ethyl cellulose; D002482:Cellulose