[The effect of nifedipine on arterial pressure and exercise tolerance in hypertensive patients].
The aim of this research was to assess whether the antihypertensive therapy with nifedipine, a dihydropyridine calcium-antagonist, is able to control hypertension not only at rest but also during exercise. So, 20 male hypertensive patients, mean age 48 years, were evaluated by symptom limited bicycle exercise (10 W/min) before and after 6 and 12 months of therapy with nifedipine in a slow releasing form (40-60 mg/day). Exercise tolerance significantly increased after 12 months of antihypertensive therapy with nifedipine (from 146 +/- 5 to 153 +/- 4 W, p < 0.05). Systolic and diastolic blood pressure decreased after 6 and 12 months both at rest (from 160 +/- 6/109 +/- 9 mmHg to 132 +/- 3/91 +/- 3 and 135 +/- 4/93 +/- 1 mmHg, respectively, both p < 0.001) and during exercise (at end exercise: from 238 +/- 7/121 +/- 5 mmHg to 216 +/- 6/106 +/- 3 and 213 +/- 6/107 +/- 3 mmHg, respectively, both p < 0.001). No significant changes in heart rate were observed during antihypertensive therapy both at rest and during exercise test. In conclusion, long-term antihypertensive therapy with nifedipine was effective in the control of hypertension both at rest and during physical stress. Moreover, an improvement in effort tolerance was observed in hypertensive patients.
Seguro
C
C
Istituto di Cardiologia, Università degli Studi, Cagliari.
Sau
F
F
Lai
C
C
Onnis
E
E
Orani
E
E
Soro
A
A
Leo
M R
MR
Cherchi
A
A
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D003692:Delayed-Action Preparations; D004341:Drug Evaluation; D017079:Exercise Tolerance / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*; D013997:Time Factors
D003692:Delayed-Action Preparations; D009543:Nifedipine
Effetto della nifedipina sulla pressione arteriosa e sulla tolleranza allo sforzo in pazienti ipertesi.