title: Antihepatotoxic C-glycosylflavones from the leaves of Allophyllus edulis var. edulis and gracilis.
abstract: From the leaves of Allophyllus edulis var. edulis and Allophyllus edulis var. gracilis nine C-glycosylflavones have been isolated and identified as schaftoside (8), vicenin-2 (9), lucenin-2 (10), isovitexin 2"-O-rhamnoside (11), cerarvensin 2"-O-rhamnoside (12), vitexin 2"-O-rhamnoside (13), isoorientin 2"-O-rhamnoside (15), orientin 2"-O-rhamnoside (16) and saponarin (17). In addition, gallic acid (2), the phenol C-glycosides bergenin (3) and 11-O-galloylbergenin (4), three flavonol 3-O-rhamnosides and a new C-glycosylflavone identified as mollupentin 2"-O-rhamnoside (14) were obtained from the leaves of Allophyllus edulis var. edulis. Their structures were elucidated on the basis of chemical and spectral data. For the first time the C-glycosylflavones were found to have remarkable anti-hepatotoxic activities against CCl4 and galactosamine cytotoxicity in primary cultured rat hepatocytes. Structure-activity relationships are discussed.
authors: Institut of Pharmaceutical Biology, Ludwig-Maximilians-University of Munich, Federal Republic of Germany.
authors: K
authors: K
authors: Hoffmann-Bohm
authors: H
authors: H
authors: Lotter
authors: O
authors: O
authors: Seligmann
authors: H
authors: H
authors: Wagner
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats
chemical_list: D005419:Flavonoids