[Synthesis of N-(2-carboxy-thieno(2,3-b)pyridin-3-yl)-amidines by the reaction with 4-oxo-4H-pyrido(3',2':4,5)-thieno(3,2-d)-1,3-oxazines with secondary cycloaliphatic amines].
4-Oxo-4H-pyrido[3',2':4,5]thieno[3,2-d]1,3-oxazines react with secondary cycloaliphatic amines to give besides the expected bisamides the amine salts of N-(2-carboxy-thieno[2,3-b]pyridine-3-yl)amidines. These compounds showed inhibitory activity against different lipoxygenases, but a small chemical stability.
Vieweg
H
H
Sektion Biowissenschaften der Universität Leipzig, Germany.
Leistner
S
S
Prantz
J
J
Böhm
N
N
Wagner
G
G
D000578:Amidines / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D003594:Cytoplasmic Granules / Q000187:drug effects; D066298:In Vitro Techniques; D008084:Lipoxygenase / Q000378:metabolism; D016859:Lipoxygenase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D010078:Oxazines / Q000737:chemistry*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D012156:Reticulocytes / Q000201:enzymology
D000578:Amidines; D016859:Lipoxygenase Inhibitors; D010078:Oxazines; D010972:Platelet Activating Factor; D011725:Pyridines; D008084:Lipoxygenase
Synthese von N-(2-Carboxy-thieno[2,3-b]pyridin-3-yl)amidenen durch Umsetzung von 4-Oxo-4H-pyrido[3',2':4,5]thieno[3,2-d]1,3-oxazinen mit sekundären cycloaliphatischen Aminen.