Actions of vasoactive intestinal polypeptide (VIP) on neocortical neurons of the rat in vitro.
The action of vasoactive intestinal polypeptide (VIP) was studied using intracellular recording techniques in neocortical neurons of the rat in vitro. When added to the perfusion medium, VIP enhanced direct excitability and increased the amplitude of the excitatory postsynaptic potential (EPSP). Effects of VIP were long-lasting and in most cases not fully reversible within the observation period. The present results suggest a role for VIP in long-lasting peptidergic modulation of excitatory synaptic components as well as direct excitability of neocortical pyramidal neurons of the adult rat.
Pawelzik
H
H
Max-Planck-Institute of Psychiatry, Clinical Institute, München, FRG.
Dodt
H U
HU
Zieglgänsberger
W
W
D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D011712:Pyramidal Tracts / Q000166:cytology / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
D014660:Vasoactive Intestinal Peptide