title: A compact centrifugal pump for cardiopulmonary bypass.
abstract: A majority of the cardiopulmonary bypass (CPB) systems still utilize bulky roller pumps. A direct-drive small centrifugal pump intended for second-generation CPB pump has been developed. The pump has a 50 mm diameter impeller and provides a 6 L/min flow at 3,000 rpm against 300 mm Hg. A flexible drive shaft allows us to separate the pump head from the console resulting in easier manipulation. An in vitro study showed that the pump generated less hemolysis (index of hemolysis = 0.0011, comparable to the value for Bio-medicus BP-80). To improve blood flow around the shaft-seal region and to reduce thrombus formation around the shaft, six holes were drilled through the impeller. In biventricular bypass experiments using calves, our pump demonstrated excellent antithrombogenicity and durability for 48 h. And the compact and atraumatic centrifugal pump system showed excellent performance and easy manipulation under actual CPB conditions in animal.
authors: Baylor College of Medicine, Department of Surgery, Houston, Texas 77030.
authors: T
authors: T
authors: Sasaki
authors: T
authors: T
authors: Jikuya
authors: T
authors: T
authors: Aizawa
authors: M
authors: M
authors: Shiono
authors: I
authors: I
authors: Sakuma
authors: S
authors: S
authors: Takatani
authors: J
authors: J
authors: Glueck
authors: G P
authors: GP
authors: Noon
authors: Y
authors: Y
authors: Nosé
authors: M E
authors: ME
authors: DeBakey
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002315:Cardiopulmonary Bypass / Q000295:instrumentation*; D002417:Cattle; D004867:Equipment Design; D006461:Hemolysis; D006801:Humans; D066298:In Vitro Techniques
chemical_list: D001672:Biocompatible Materials