[Effect of baoyuantang on erythroid progenitor and clinical observation in chronic renal failure patients].
The erythroid colony formating ability and the therapeutic efficacy were investigated in patients with chronic renal failure (CRF) before and after treatment with baoyuantang. The results showed that the number of CFU-E, BFU-E of bone marrow was found lower in CRF patients than that in normal controls, and there was inhibitory action in the CRF serum on the number of CFU-E, BFU-E of normal human bone marrow. After treatment with baoyuantang, the amount of Hb was increased and creatinine decreased in CRF patients, and its effective rate reached 83.3%. The above-mentioned inhibitory action in CRF serum was also reduced post-treatment. The results indicated that baoyuantang could increase the ability for proliferation and differentiation of erythroid progenitor and adjust anemia in CRF patient.
Jin
Y P
YP
2nd Affiliated Hospital of Human Medical University, Changsha.
Song
Q C
QC
Wu
H
H
D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D003114:Colony-Forming Units Assay; D003404:Creatinine / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D015672:Erythroid Precursor Cells / Q000187:drug effects*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D005894:Panax; D010946:Plants, Medicinal; D016711:Yang Deficiency / Q000188:drug therapy
D004365:Drugs, Chinese Herbal; D006454:Hemoglobins; D003404:Creatinine