Peptide-MHC interaction in autoimmunity.
Our increased understanding of the molecular basis of autoimmunity owes much to an appreciation of general principles governing peptide-MHC interactions. Such understanding may help resolve long-standing questions concerning autoimmune diseases and aid development of improved therapeutic strategies for their treatment.
Fairchild
P J
PJ
Department of Pathology, Cambridge University, UK.
Wraith
D C
DC
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D001327:Autoimmune Diseases / Q000628:therapy; D015551:Autoimmunity / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D000949:Histocompatibility Antigens Class II / Q000378:metabolism*; D016056:Immunodominant Epitopes / Q000276:immunology; D007167:Immunotherapy; D010455:Peptides / Q000378:metabolism*; D011485:Protein Binding; D013601:T-Lymphocytes / Q000276:immunology
D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D016056:Immunodominant Epitopes; D010455:Peptides