[Hormone therapy using tamoxifen in unresectable carcinoma of the pancreas--preliminary study].
In 1981 Greenway and co-authors reported the existence of estrogen receptor in tumor tissue of the pancreas. We have tried hormone therapy using tamoxifen in 4 of 11 patients with unresectable carcinoma of the pancreas in whom expandable metallic stents were inserted for the palliation of obstructive jaundice. The mean survival period in these 4 patients was 235 days, and 2 of them had a remarkably long survival of 321 and 463 days respectively. On the other hand, the mean survival was 128 days in 7 control patients. We therefore evaluated this new therapy with tamoxifen as effective in patients with unresectable carcinoma of the pancreas.
Morita
S
S
Department of Radiology, Kochi Municipal Central Hospital.
Motohara
T
T
Ogawa
K
K
Horimi
T
T
D004967:Estrogens / Q000502:physiology*; D006801:Humans; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy*; D010190:Pancreatic Neoplasms / Q000188:drug therapy*; D013629:Tamoxifen / Q000627:therapeutic use*
D004967:Estrogens; D013629:Tamoxifen