title: NG-011 and NG-012, novel potentiators of nerve growth factor. I. Taxonomy, isolation, and physico-chemical and biological properties.
abstract: NG-011 and NG-012, novel potentiators of nerve growth factor (NGF), were isolated from the culture broth of Penicillium verruculosum F-4542, together with 3,4-dihydro-6,8-dihydroxy-3-methylisocoumarin. They potentiated the neurite outgrowth induced by NGF in rat pheochromocytoma cell line (PC12).
authors: Research Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
authors: M
authors: M
authors: Ito
authors: M
authors: M
authors: Maruhashi
authors: N
authors: N
authors: Sakai
authors: K
authors: K
authors: Mizoue
authors: K
authors: K
authors: Hanada
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D049934:Isocoumarins; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009414:Nerve Growth Factors / Q000494:pharmacology*; D016501:Neurites / Q000187:drug effects*; D016716:PC12 Cells; D010407:Penicillium / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats
chemical_list: D000900:Anti-Bacterial Agents; D003374:Coumarins; D049934:Isocoumarins; D007783:Lactones; D009414:Nerve Growth Factors; D010636:Phenols; C078926:NG 011; C070622:6-hydroxymellein