Occurrence of melanoma in "dysplastic" nevus spilus: report of case and analysis by flow cytometry.
We report a case of melanoma arising in a large nevus spilus. On histologic examination, the nevus spilus had diagnostic features of melanocytic dysplasia. Further characterization by flow cytometry showed DNA-aneuploidy within the melanoma as well as in one of the darker pigmented papules within the nevus spilus. The significance of this finding and a review of melanomas originating in nevi spili are presented.
Kurban
R S
RS
Pathology Department, Massachusetts General Hospital, Harvard Medical School, Boston.
Preffer
F I
FI
Sober
A J
AJ
Mihm
M C
MC
Barnhill
R L
RL
D000328:Adult; D000368:Aged; D004416:Dysplastic Nevus Syndrome / Q000150:complications* / Q000473:pathology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008545:Melanoma / Q000150:complications* / Q000473:pathology*; D008875:Middle Aged; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology*