title: [A new marker of aggressivity of breast cancers: loss of heterozygote on chromosome 7q].
abstract: The etiology of breast cancer is a complex interplay of various factors, including genetic alterations. A number of studies have been made to identify and characterize mutations that frequently occur during breast tumorigenesis. In this paper, we have described a new deletion, located on the long arm of chromosome 7. Patients whose tumor carried a deletion on chromosome 7q had a significantly shorter survival time. These findings identify the long arm of chromosome 7 as a candidate region for a putative tumor (or metastasis) suppressor gene.
authors: Laboratoire d'oncovirologie, centre René-Huguenin, St-Cloud, France.
authors: I
authors: I
authors: Bièche
authors: M H
authors: MH
authors: Champème
authors: F
authors: F
authors: Matifas
authors: K
authors: K
authors: Hacène
authors: R
authors: R
authors: Lidereau
mesh_terms: D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000235:genetics*; D002872:Chromosome Deletion; D002897:Chromosomes, Human, Pair 7; D005260:Female; D016147:Genes, Tumor Suppressor / Q000235:genetics; D005819:Genetic Markers; D006579:Heterozygote; D006801:Humans; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D005819:Genetic Markers
vernacular_title: Un nouveau marqueur de l'agressivité des tumeurs du sein: les pertes d'hétérozygotie sur le chromosome 7q.