Antiphospholipid syndrome in a child with trisomy 21: the relationship between anticardiolipin G antibodies and the von Willebrand factor.
A young child with trisomy 21 developed severe multiple arterial thromboses in a three-phase clinical course which proved fatal. The episodes were characterized by high levels of both IgG anticardiolipin antibodies and the von Willebrand factor. The data suggest that there is a relationship between these two elements and the clinical events which followed.
Guariso
G
G
Department of Pediatric Clinics, University of Padova, Italy.
Ruffatti
A
A
Casonato
A
A
Drigo
P
P
Ghirardello
A
A
Zancan
L
L
D017153:Antibodies, Anticardiolipin / Q000032:analysis*; D016736:Antiphospholipid Syndrome / Q000097:blood / Q000150:complications / Q000276:immunology*; D004314:Down Syndrome / Q000097:blood / Q000150:complications / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007223:Infant; D008297:Male; D013927:Thrombosis / Q000150:complications; D014841:von Willebrand Factor / Q000032:analysis*
D017153:Antibodies, Anticardiolipin; D007074:Immunoglobulin G; D014841:von Willebrand Factor