title: Acute myelocytic leukemia associated with thrombocytosis and inv 3(q21.3; q26.2) in a case of Grönbland-Strandberg syndrome.
abstract: Grönbland-Strandberg syndrome is an inherited connective tissue disorder with cutaneous, ophthalmologic, and systemic manifestations. Here we report a case of AML with thrombocytosis arising in a patient with this syndrome. Karyotypic analysis of bone marrow cells revealed the inversion 3 (q21.3;q26.2). To our knowledge, this is the first report of the association of AML with thrombocytosis and Grönbland-Strandberg syndrome. This might be a coincidental association, but it suggests some interesting speculations regarding the pathogenesis of these diseases.
authors: First Department of Internal Medicine, Kagawa Medical School, Japan.
authors: T
authors: T
authors: Tasaka
authors: M
authors: M
authors: Nagai
authors: Y
authors: Y
authors: Kubota
authors: K
authors: K
authors: Sasaki
authors: M
authors: M
authors: Murata
authors: T
authors: T
authors: Taoka
authors: K
authors: K
authors: Ikeda
authors: T
authors: T
authors: Tanaka
authors: J
authors: J
authors: Takahara
authors: S
authors: S
authors: Irino
mesh_terms: D007446:Chromosome Inversion; D002893:Chromosomes, Human, Pair 3; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011561:Pseudoxanthoma Elasticum / Q000150:complications*; D013922:Thrombocytosis / Q000150:complications*