Modulation of receptor-dependent increase of calcium ions in human platelets by taurine.
Taurine (2-aminoethanesulfonic acid, CAS 107-35-7) is present in high concentrations in platelets. It suppresses bronchial responses to platelet-activating factor (PAF) and inhibits aggregation induced by ADP. In the present experiments human platelet calcium responses to PAF were measured by a fluorescent label "Quin-2" method. Preincubation with 0.01 mol/l of taurine decreased effects of PAF by 250 nmol/l if the initial Ca intracellular response (delta Ca2+) to inductor was more than 400 nmol/l. If the initial response to inductor was less than 150 nmol/l, taurine did not affect the response to inductor if PAF effect was in delta Ca2+ range of 150-400 nmol/l. Hence, some effects of taurine may be ascribed to its modulating influence on secondary Ca2+ messenger.
Atahanov
S E
SE
Cardiology Research Center, Moscow, Russia.
Elizarova
E P
EP
D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000097:blood*; D003600:Cytosol / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D011955:Receptors, Drug / Q000187:drug effects*; D013654:Taurine / Q000494:pharmacology*
D011955:Receptors, Drug; D013654:Taurine; D002118:Calcium