Genital squamous-cell carcinoma after PUVA therapy.
Among our patients treated with very high doses of PUVA (more than 1,500 J/cm2) for recalcitrant disseminated psoriasis, three developed squamous-cell carcinoma of the genitalia. The tumors were located on the scrotum in all patients; one of them displayed three times running a carcinoma of the dorsal aspect of the penis. All these genital tumors arose more than 2 years after PUVA cessation, in patients with previous arsenic and tar treatment.
de la Brassinne
M
M
Department of Dermatology, University of Liège, Belgium.
Richert
B
B
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D005834:Genital Neoplasms, Male / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D011701:PUVA Therapy / Q000009:adverse effects*; D011565:Psoriasis / Q000188:drug therapy; D012611:Scrotum