Convergent serotonin and GABA innervation of VIP neurons in the suprachiasmatic nucleus demonstrated by triple labeling in the rat.
By means of a combination of serotonin (5-HT) uptake radioautography and dual immunocytochemistry, vasoactive intestinal polypeptide (VIP) neurons in the suprachiasmatic nucleus are demonstrated to simultaneously receive both 5-HT and GABA afferents at their somatic and dendritic levels. These data constitute a further step towards the improved characterization of the morphological substrate of the integrative function of these neurons, which are known to play an important role in the delivery of light-mediated rhythmic signals to other parts of the brain.
François-Bellan
A M
AM
Unité de Neuroendocrinologie Expérimentale, INSERM U297, Marseille, France.
Bosler
O
O
D000818:Animals; D001345:Autoradiography; D003712:Dendrites / Q000648:ultrastructure; D006651:Histocytochemistry; D008297:Male; D008854:Microscopy, Electron; D009474:Neurons / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000502:physiology*; D013493:Suprachiasmatic Nucleus / Q000033:anatomy & histology / Q000166:cytology* / Q000502:physiology; D016707:Tissue Fixation; D014660:Vasoactive Intestinal Peptide / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D012701:Serotonin; D014660:Vasoactive Intestinal Peptide; D005680:gamma-Aminobutyric Acid