[Effects of diisopropylfluorophosphate, paraoxon and dichlophos on [3H] quinuclidinyl benzylate binding to the rat striatum synaptic membranes].
The binding of [3H] quinuclidinyl benzilate (QNB) to rat striatum membranes after diisopropylfluorophosphate (DFP) induced seizures was characterized. There was a 36% decrease in Kd and a 33% decrease in the number of muscarinic receptors. Paraoxon caused inhibition fo [3H] QNB binding to the striatal membranes of intact rats. It is possible that a direct action of DFP on the muscarinic receptor is not the cause of anti-cholinesterase-induced changes in [3H] QNB binding.
Golovko
A I
AI
Sofronov
G A
GA
Nikolaeva
T V
TV
Kliuntina
T V
TV
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004006:Dichlorvos / Q000494:pharmacology*; D066298:In Vitro Techniques; D007531:Isoflurophate / Q000494:pharmacology*; D008297:Male; D010261:Paraoxon / Q000494:pharmacology*; D011813:Quinuclidinyl Benzilate / Q000378:metabolism*; D051381:Rats; D011976:Receptors, Muscarinic / Q000187:drug effects; D012640:Seizures / Q000378:metabolism; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*
D011976:Receptors, Muscarinic; D007531:Isoflurophate; D011813:Quinuclidinyl Benzilate; D004006:Dichlorvos; D010261:Paraoxon
Vliianie diizopropilftorfosfata, paraoksona i dikhlofosa na sviazyvanie [3H] khinuklidinil benzilata s sinapticheskimi membranami striatuma krys.