title: Effect of prolonged, continuous rectal distention on mouth-to-cecum and colonic transit time in pigs.
abstract: The effect of prolonged (6 h), continuous rectal distention on mouth-to-cecum and colonic transit time was studied in four unrestrained pigs. Mouth-to-cecum transit time was determined from samples of cecal efflux using the phenol red dye technique. Colonic transit time was assessed with radiopaque markers that were injected into the cecum before each trial. Rectal distention was applied 2-1/2 h before feeding, during feeding, and 3-1/2 h after feeding. No distention was applied during control conditions. Stools were collected for 48 h after marker application. Rectal distention increased mouth-to-cecum transit time (p < 0.05). Colonic transit time was also prolonged by rectal distention as shown by a significant decrease in the number of markers excreted within 36 h (p < 0.05). Rectal distention for 6 h increased colonic transit time up to 30 h following distention and prolonged mouth-to-cecum transit of a high fat liquid meal.
authors: Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD.
authors: F
authors: F
authors: Musial
authors: M D
authors: MD
authors: Crowell
authors: A W
authors: AW
authors: French
authors: N
authors: N
authors: Guiv
mesh_terms: D000818:Animals; D002432:Cecum / Q000502:physiology; D003106:Colon / Q000502:physiology; D003672:Defecation / Q000502:physiology; D005260:Female; D005772:Gastrointestinal Transit / Q000502:physiology*; D012007:Rectum / Q000502:physiology*; D013552:Swine; D013556:Swine, Miniature