Involvement of swimming-induced acute stress in the sensitivity of rat vs deferens to norepinephrine.
1. The effects of swimming-induced stress on rat sensitivity to norepinephrine were studied. 2. Through microscopic analysis of the stomach from swimming stressed rats significant ulceration was observed, confirming that the stress situation was really present. 3. Sensitivity to norepinephrine either in the presence or in the absence of cocaine and propranolol in acutely swimming stressed rats was not altered significantly. 4. Bilateral adrenalectomy was performed in rats 2 days before swimming and acute stress resulted in a supersensitivity to norepinephrine, indicating that adrenal glands may, at least, partially mediate the sensitivity to this drug in vasa deferentia isolated from these animals.
Bispo
D L
DL
Department of Pharmacology, Institute of Bioscience--São Paulo State University (UNESP), Botucatu, Brazil.
Pereira
O C
OC
D000311:Adrenal Glands / Q000187:drug effects; D000315:Adrenalectomy; D000818:Animals; D003042:Cocaine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000473:pathology; D013315:Stress, Psychological / Q000473:pathology / Q000503:physiopathology*; D013550:Swimming; D013564:Sympathetic Nervous System / Q000187:drug effects; D014649:Vas Deferens / Q000187:drug effects
D011433:Propranolol; D003042:Cocaine; D009638:Norepinephrine