[Immunodiagnosis of retinoblastoma].
To improve the accuracy of early diagnosis of retinoblastoma, the authors have examined a number of cellular and humoral immunity parameters in 188 children with retinoblastomas, in 57 ones with nontumorous conditions of the eyes, and in healthy controls. Stages III-IV retinoblastoma was found associated with reduced blood levels of IgG and IgA and a still more marked reduction of both in the lacrimal fluid (4-fold), with reduced blood T lymphocyte count (by 1.5 times), decreased lymphocyte blastogenesis response to phytohemagglutinin (by 8-9 times), reduced leukocyte migration activity (MI = 79 +/- 10%), reduced serum thymic activity (by 2.5 times). The early (I-II) stage of the disease involves a lowering of only lacrimal fluid IgA (2-fold) and of the leukocyte migration index (MI) (89 +/- 2%). This index was found to be an important specific indicator for the early preoperative diagnosis of retinoblastoma. Leukocyte migration inhibition (MI less than 95%) by retinoblastoma antigens was observed only if this tumor was present. In cases with the nontumorous conditions and in health retinoblastoma antigens as a rule stimulated the leukocyte migration (MI over 95%).
Khvatova
A V
AV
Skriabina
O A
OA
Kargina
I B
IB
Arion
V Ia
VIa
Kashirina
N M
NM
D002464:Cell Migration Inhibition; D002675:Child, Preschool; D005134:Eye Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D017098:IgA Deficiency / Q000175:diagnosis* / Q000209:etiology; D017099:IgG Deficiency / Q000175:diagnosis* / Q000209:etiology; D005779:Immunodiffusion; D007223:Infant; D007958:Leukocyte Count; D008231:Lymphopenia / Q000175:diagnosis* / Q000209:etiology; D012175:Retinoblastoma / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology
Ob immunodiagnostike retinoblastomy.