Coronary artery spasm and acute myocardial infarction in naproxen-associated anaphylactic reaction.
We present the case of a 43-year-old man who suffered an acute myocardial infarction after oral administration of 250 mg of naproxen, prescribed as antiinflammatory-analgesic agent after tooth extraction. Both intradermal skin test and human basophil degranulation test were positive to naproxen. These findings suggest a naproxen-associated anaphylactic reaction with concomitant coronary artery spasm and posteroinferior infarction, a clinical event previously not reported with the use of this drug.
Cisteró
A
A
Allergy Unit, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Urías
S
S
Guindo
J
J
Lleonart
R
R
Garcia-Moll
M
M
Geli
A
A
Bayés de Luna
A
A
D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced* / Q000150:complications; D003329:Coronary Vasospasm / Q000209:etiology*; D004342:Drug Hypersensitivity / Q000209:etiology*; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000209:etiology*; D009288:Naproxen / Q000008:administration & dosage / Q000009:adverse effects*
D009288:Naproxen