Intradermal and percutaneous transudation of IgG1 and transferrin in sheep.
The leakage of [125I]-IgG1 into skin sites following injection of mediators of enhanced vascular permeability and during induction of transudates on the skin surface under negative pressure was examined to determine whether IgG is selectively transported into cutaneous transudates. 111In-transferrin was employed as a marker of plasma leakage unaided by selective transport. The leakage of IgG1 into interstitial spaces of untreated skin, into inflammatory transudates and into transudate fluid drawn to the skin surface under vacuum occurred at a lower rate than did leakage of transferrin. No evidence was found in favour of a selective transport mechanism to aid transport of IgG1 into extravascular skin compartments.
Colditz
I G
IG
CSIRO Division of Animal Health, Armidale, New South Wales, Australia.
Altmann
K G
KG
Watson
D L
DL
D000818:Animals; D001693:Biological Transport, Active; D002199:Capillary Permeability / Q000187:drug effects / Q000502:physiology; D005122:Exudates and Transudates / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism*; D008297:Male; D012756:Sheep / Q000378:metabolism* / Q000502:physiology; D012867:Skin / Q000378:metabolism*; D014168:Transferrin / Q000378:metabolism*
D007074:Immunoglobulin G; D014168:Transferrin