Application of carboxylic-phospholanic mixed anhydrides to fragment coupling in peptide synthesis.
The application of 1-oxo-1-chlorophospholane as a novel reagent for the in situ activation of peptide fragments for use in peptide bond forming reactions, either in liquid or solid phase, has been examined. 24.1 MHz 31P NMR spectroscopy has been employed to follow the formation, stability and reactivity of the intermediate phospholanic-carboxylic mixed anhydride.
Poulos
C
C
Department of Chemistry, University of Patras, Greece.
Ashton
C P
CP
Green
J
J
Ogunjobi
O M
OM
Ramage
R
R
Tsegenidis
T
T
D000812:Anhydrides / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D015394:Molecular Structure; D010081:Oxazolone / Q000032:analysis*; D010446:Peptide Fragments / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis*; D010721:Phosphinic Acids / Q000737:chemistry*; D010758:Phosphorus
D000812:Anhydrides; D002264:Carboxylic Acids; D010446:Peptide Fragments; D010455:Peptides; D010721:Phosphinic Acids; D010081:Oxazolone; D010758:Phosphorus