Changes in anti-erythrocyte membrane antibody level of dogs experimentally infected with Babesia gibsoni.
To account for the conflict between the excessive destruction of erythrocytes and the number of parasitized erythrocytes in dogs infected with Babesia gibsoni, we examined the correlation between anti-erythrocyte membrane antibody level (AEMAL) and the number of erythrocytes (RBC count) in dogs with experimentally induced babesiosis using hematological examination and an enzyme linked immunosorbent assay (ELISA). In the infected dogs without splenectomy, more prominent reduction in RBC count accompanied with the elevated AEMAL was presented than anticipated from parasitemia until the 21st day. Furthermore, autoagglutinated erythrocytes and spherocytes were demonstrated in blood films. These results suggest that a humoral immunologic mechanism may be involved in a decrease in RBC count in dogs infected with B. gibsoni.
Adachi
K
K
Department of Veterinary Internal Medicine, Miyazaki University, Japan.
Makimura
S
S
D000740:Anemia / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D000818:Animals; D001323:Autoantibodies / Q000097:blood*; D001404:Babesiosis / Q000276:immunology*; D004283:Dog Diseases / Q000276:immunology* / Q000469:parasitology; D004285:Dogs; D004912:Erythrocytes / Q000276:immunology*; D008297:Male
D001323:Autoantibodies