[The evaluation of the mutagenic activity of pertussis vaccinal preparations].
Two vaccine preparations obtained from Bordetella pertussis, whole-cell vaccine constituting one of the components of adsorbed DPT vaccine and acellular vaccine, were tested for mutagenicity. The doses of the preparations covered the range 1-100 ED50. Ames' test and the metaphase analysis of marrow cells of C57BL/6J mice were used. The acellular preparation was also tested on thymectomized mice, taking into consideration chromosomal aberrations in marrow metaphases. Whole-cell and acellular pertussis vaccines did not induce mutations in Salmonella typhimurium and chromosomal aberrations in mouse marrow cells.
Bolgareva
G M
GM
Krivtsova
E K
EK
Revazova
Iu A
IuA
Zakharova
N S
NS
Bazhanova
I G
IG
Remova
T N
TN
Shmeleva
E I
EI
Mertsalova
N U
NU
Sukhinova
E E
EE
Revazova
E S
ES
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000648:ultrastructure; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D005798:Genes, Bacterial / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016296:Mutagenesis / Q000187:drug effects*; D009152:Mutagenicity Tests; D010567:Pertussis Vaccine / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D015164:Vaccines, Inactivated / Q000633:toxicity
D010567:Pertussis Vaccine; D015164:Vaccines, Inactivated
Otsenka mutagennoĭ aktivnosti kokliushnykh vaktsinal'nykh preparatov.