A tryptophan-substituted member of the AKH/RPCH family isolated from a stick insect corpus cardiacum.
A neuropeptide, Cam-HrTH-I, has been isolated from the corpus cardiacum of the Indian stick insect Carausius morosus. The peptide causes hyperlipaemia in Locusta migratoria and hypertrehalosaemia in Periplaneta americana and is related to the previously isolated Cam-HrTH-II (pGlu-Leu-Thr-Phe-Thr-Pro-Asn-Trp-Gly-Thr-NH2) by substitution, apparently by a hexose, on the Trp residue. This appears to be the first example of such substitution on a Trp residue.
Gäde
G
G
Zoology Department, University of Cape Town, Rondebosch, Republic of South Africa.
Kellner
R
R
Rinehart
K L
KL
Proefke
M L
ML
D000595:Amino Acid Sequence; D000818:Animals; D001681:Biological Assay; D002851:Chromatography, High Pressure Liquid; D006110:Grasshoppers / Q000187:drug effects*; D007301:Insect Hormones / Q000302:isolation & purification* / Q000494:pharmacology; D008297:Male; D008969:Molecular Sequence Data; D009479:Neuropeptides / Q000302:isolation & purification* / Q000494:pharmacology; D009987:Orthoptera / Q000502:physiology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014364:Tryptophan
D007301:Insect Hormones; D009479:Neuropeptides; C079084:hypertrehalosaemic hormone I, Carausius morosus; D014364:Tryptophan