t(12;22)(q13;q13) and trisomy 8 are nonrandom aberrations in clear-cell sarcoma.
We report a case of clear-cell sarcoma with a t(12;22)(q13;q13) and multiple copies of chromosome 8 in addition to other abnormalities. An identical or similar translocation has previously been reported in this type of tumor, suggesting that the t(12;22) is a primary cytogenetic change in the pathogenesis of a subset of clear-cell sarcomas. In addition, the presence of extra copies of chromosome 8, commonly noted in our case and others, suggests that it represents a nonrandom secondary change in these tumors.
Rodriguez
E
E
Laboratory of Cancer Genetics, Sloan-Kettering Institute, New York, NY 10021.
Sreekantaiah
C
C
Reuter
V E
VE
Motzer
R J
RJ
Chaganti
R S
RS
D002869:Chromosome Aberrations; D002881:Chromosomes, Human, Pair 12; D002892:Chromosomes, Human, Pair 22; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007621:Karyotyping; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D012509:Sarcoma / Q000235:genetics* / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000235:genetics*; D013736:Testicular Neoplasms / Q000235:genetics* / Q000601:surgery; D014178:Translocation, Genetic; D014314:Trisomy