title: Studies of oxidative stress in cellular systems. The interaction of monocytes and erythrocytes.
abstract: 1H spin echo NMR spectroscopy is used to follow the interaction of intact and viable erythrocytes and monocytes obtained from different sources in mixed cultures. After a lag time (270 min) erythrocyte glutathione is observed to become more oxidised. This result is believed to occur as a consequence of monocyte activation generating hydrogen peroxide or hypochlorous acid, which is targeted at the erythrocyte. The red cell in turn employs its sulphydryl system as an anti-oxidant defence.
authors: Department of Pure and Applied Chemistry, Strathclyde University, Glasgow, UK.
authors: P E
authors: PE
authors: McGowan
authors: J
authors: J
authors: Reglinski
authors: W E
authors: WE
authors: Smith
authors: R
authors: R
authors: Wilson
authors: R D
authors: RD
authors: Sturrock
mesh_terms: D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D009000:Monocytes / Q000378:metabolism*; D010084:Oxidation-Reduction