[The prenatal toxicity of butenylisothiocyanate in rats].
Butenyl isothiocyanate (BylITC), the hydrolysis product of the glucosinolate gluconapin, present in various cruciferous vegetables and in rapeseed, was administered in oral doses of 0, 50, 100 and 150 mg/kg to pregnant rats on day 12 to 19 of gestation. Maternal toxicity was indicated by reduced body weight gain and increases in the weights of liver and kidneys. BylITC doses of 100 and 150 mg/kg caused retardation of fetal growth and ossification.
Bleyl
D W
DW
Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke, Bundesrepublik Deutschland.
Lewerenz
H J
HJ
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005314:Embryonic and Fetal Development / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000187:drug effects*; D005865:Gestational Age; D017879:Isothiocyanates; D009929:Organ Size / Q000187:drug effects; D010947:Plants, Toxic / Q000737:chemistry*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013861:Thiocyanates / Q000633:toxicity*
D017879:Isothiocyanates; D013861:Thiocyanates; C079114:butenylisothiocyanate
Untersuchungen der Pränataltoxizität von Butenylisothiocyanat an Ratten.