A case of subepidermal blister disease associated with autoantibody against 450 kD protein.
We report a case of subepidermal blister disease with eruptions distributed on the trunk and extremities. The blisters regressed after administration of corticosteroid and cyclophosphamide. An immunoblot analysis revealed that the patient's serum reacted exclusively with a 450-kD epidermal polypeptide. It did not react with a 230-kD or a 180-kD bullous pemphigoid antigen. The immunofluorescence study showed the patient's serum reacted with the basement membrane zone of human skin.
Fujiwara
S
S
Department of Dermatology, Medical College of Oita, Japan.
Shinkai
H
H
Takayasu
S
S
Owaribe
K
K
Tsukita
S
S
Kageshita
T
T
D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood*; D001768:Blister / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D004817:Epidermis; D006801:Humans; D008297:Male; D008970:Molecular Weight; D010391:Pemphigoid, Bullous / Q000097:blood / Q000175:diagnosis / Q000276:immunology*
D001323:Autoantibodies