A lineage-specific t(1;14)(q21;q32) as an early event in development of B-cell clonal expansion.
We report a patient in whom a cell line of 47,XY,+X,t(1;14)(q21;q32) constitution was found in a lymph node excised from the neck. Histologic examination and immunophenotyping both in situ and by flow cytometry failed to confirm a diagnosis of B-cell lymphoma, but Southern analysis indicated the presence of B-cell clonal expansion. These observations support the concept that primary chromosomal abnormalities occur in clonal expansions in the very earliest stages of tumorigenesis.
Pinkerton
P H
PH
Department of Laboratory Haematology, Sunnybrook Health Science Centre, Toronto, Ontario, Canada.
Reis
M D
MD
DeCoteau
J
J
Srigley
J R
JR
Dubé
I D
ID
London
B
B
D001402:B-Lymphocytes / Q000473:pathology*; D015139:Blotting, Southern; D002871:Chromosome Banding; D002999:Clone Cells; D005434:Flow Cytometry; D006801:Humans; D006965:Hyperplasia; D007124:Immunoenzyme Techniques; D016130:Immunophenotyping; D007621:Karyotyping; D008198:Lymph Nodes / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic