[The virulence of Streptococcus pneumoniae strains--the causative agents of pneumococcal infection at different sites].
A total of 256 S. pneumoniae strains, the causative agents of infectious processes with different localization, were studied for their virulence (in experiments on mice), neuraminidase and aldolase-protease activity (APA). In pneumococcal strains isolated 18-20 hours after intraperitoneal infection their virulence for mice increased, on the average, 1,000-fold and the average level of extracellular and cellular neuraminidase and APA increased 2- to 5-fold in comparison with the initial values. Pneumococcal strains causing acute pneumococcal infections with different localization, or the aggravation of such infections, exhibited higher virulence for mice and higher levels of neuraminidase and APA, while the inflammatory process at the period of clinical remissions was mainly maintained by S. pneumoniae cultures with low virulence.
Vishniakova
L A
LA
Reztsova
Iu V
IuV
D000818:Animals; D010450:Endopeptidases / Q000032:analysis; D005634:Fructose-Bisphosphate Aldolase / Q000032:analysis; D006801:Humans; D051379:Mice; D009439:Neuraminidase / Q000032:analysis; D011008:Pneumococcal Infections / Q000209:etiology* / Q000382:microbiology; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification / Q000201:enzymology / Q000302:isolation & purification / Q000472:pathogenicity*; D013997:Time Factors; D014774:Virulence
D009439:Neuraminidase; D010450:Endopeptidases; D005634:Fructose-Bisphosphate Aldolase
Virulentnost' shtammov Streptococcus pneumoniae--vozbuditeleĭ pnevmokokkovoĭ infektsii razlichnoĭ lokalizatsii.