title: [Multimodal management of bone sarcomas in children].
abstract: Osteogenic sarcoma and Ewing's sarcoma are the most common malignant bone tumors in childhood and adolescence. Marked improvement in prognosis and long-term survival have been achieved using combined modality protocols. We present a retrospective analysis of our experience with combined therapy of malignant bone tumors in children. Among 20 (ranging in age from 6-16, mean 11.4 years) with Ewing's sarcoma, 14 (70%) had complete remission by the end of treatment, 5 (25%) had partial response and 1 did not respond. The overall 10-year actuarial survival was 64%. Of the 10 with osteogenic sarcoma, 5 (50%) fully responded and are alive, 4 (40%) died after a partial or no response and 1 is receiving second-line therapy after partial response to primary treatment. The 10-year actuarial survival was 37.5% and the efficacy of combined modality therapy was demonstrated. However, further efforts are needed to arrive at optimal treatment for improved outcome.
authors: Northern Israel Oncology Center, Haifa.
authors: M
authors: M
authors: Ben-Arush
authors: E
authors: E
authors: Rosenblatt
authors: A
authors: A
authors: Kuten
authors: I
authors: I
authors: Meler
authors: V
authors: V
authors: Bialik
authors: M
authors: M
authors: Stein
mesh_terms: D000206:Actuarial Analysis; D000293:Adolescent; D001859:Bone Neoplasms / Q000401:mortality / Q000628:therapy*; D002648:Child; D003131:Combined Modality Therapy; D006801:Humans; D012516:Osteosarcoma / Q000401:mortality / Q000628:therapy*; D012074:Remission Induction; D012189:Retrospective Studies; D012512:Sarcoma, Ewing / Q000401:mortality / Q000628:therapy*; D015996:Survival Rate