title: Effects of nimodipine on brain blood flow following acute brain ischemia in the newborn piglet.
abstract: We examined the effect of the calcium channel blocker nimodipine on postischemic hypoperfusion in the newborn piglet brain. A severe pneumothorax (SP) was induced by injecting air into the right thorax until the mean arterial blood pressure fell to 25% of baseline and was maintained for 4 min. Blood flow was immediately reduced 70-90% from baseline in each brain region during SP. In untreated animals postischemic hypoperfusion existed at 60 min, following recovery from SP with regional brain blood flow reduced 20-30% from baseline. Nimodipine infusion after SP prevented postischemic hypoperfusion in all brain regions and increased blood flows by as much as 40% above baseline in midbrain and brainstem structures. Nimodipine infusion began after severe brain ischemia prevented postischemic hypoperfusion and enhanced brain blood flow in this model.
authors: Department of Pediatrics, East Carolina University School of Medicine, Greenville, N.C. 27858-4353.
authors: C S
authors: CS
authors: Easley
authors: F S
authors: FS
authors: Wartman
authors: A E
authors: AE
authors: Kopelman
authors: T M
authors: TM
authors: Louis
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000098:blood supply; D002545:Brain Ischemia / Q000188:drug therapy*; D006863:Hydrogen-Ion Concentration; D009553:Nimodipine / Q000627:therapeutic use*; D011030:Pneumothorax; D013552:Swine
chemical_list: D009553:Nimodipine