Prevention of heterotopic bone formation with low dose radiation therapy.
Radiation therapy to control heterotopic bone formation does not appear to be commonly used in sites other than hips where effective control is evident following arthroplasty. Reported are the results in 12 sites in 10 patients including three with treatment to the elbow, humerus, and ulna. Ten sites received a radiation dose of 10.00 Gy, one 16.00 Gy, and one was treated to 20.00 Gy, all delivered in 2.00 Gy fractions. Preoperative and follow-up x-rays were reviewed and graded. There was no clinically significant regrowth of heterotopic bone. Five sites (42%) demonstrated mild regrowth or persistence following surgery with the other seven (58%) showing no evidence of heterotopic bone. No complications were seen. Radiation therapy is effective for the prevention of heterotopic bone after total hip arthroplasties as well as surgery for fractures to other areas.
Rubenstein
J H
JH
Radiation Therapy Regional Center, Fort Myers.
Salenius
S A
SA
Blitzer
P H
PH
Katin
M J
MJ
Dosoretz
D E
DE
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001842:Bone and Bones / Q000528:radiation effects*; D005260:Female; D005500:Follow-Up Studies; D005593:Fracture Fixation, Internal; D006622:Hip Prosthesis; D006801:Humans; D006811:Humerus / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000517:prevention & control / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D012086:Reoperation; D012784:Shoulder Fractures / Q000601:surgery; D014457:Ulna / Q000528:radiation effects; D000092464:Elbow Injuries