Principal components and multidimensional scaling of auditory and visual event-related potential topography.
Principal components analysis and metric multidimensional scaling were used to assess auditory and visual event-related potential topography in healthy late-middle-aged and elderly adults (n = 20). Binaurally elicited auditory evoked potentials and full-field checkerboard pattern reversal visual event-related potentials were recorded from 28 scalp sites. The zero-lag, cross-correlations of all waveforms for 300 msec post-stimulus epochs were obtained and separate analyses of the auditory and visual data were performed. Ultimately, three of the four dimensions identified in the principal components and multidimensional scaling solutions were similar and represented electrode site differences in (1) the anterior-posterior plane; (2) laterality; and, (3) the proximal-distal relation to midline. The remaining multidimensional scaling axis appeared to reflect effects specific to the modality of stimulation. Under auditory stimulation, the temporal and central-parietal sites were distinct from other scalp regions, whereas under visual stimulation, the occipital and frontal sites were distinctive. Although the results of the principal component analyses were conceptually similar to the multidimensional scaling outcomes, there were consistent differences between them. The findings provide empirical support for the validity of these multivariate methods in topographic analysis.
Pollock
V E
VE
Department of Psychiatry, University of Southern California, Los Angeles.
Cliff
N
N
D000161:Acoustic Stimulation; D000368:Aged; D000704:Analysis of Variance; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation