[Anemia and recurrences in acute lymphoblastic leukemia in children after the treatment and the frequency of the erythroblasts with micronuclei].
A retrospective analysis of the relation of relapses and anaemias to the frequency of micronucleated erythroblasts in bone marrow smear in 140 children with acute lymphoblastic leukaemia after BFM and Memphis schemes of therapy was carried out. The anaemias correlated with the frequency of micronucleated erythroblasts in statistically significant manner. Correlation concerning relapses, was not shown. The frequency of micronucleated erythroblasts in children treated by BFM scheme is lower than by Memphis scheme. This suggests smaller genotoxicity of BFM scheme therapy.
Rytwiński
K
K
Pracowni Hematologii i Immuologii Klinicznej Instytutu Onkologii Gliwicach.
Sońta-Jakimczyk
D
D
Konopacka
M
M
Ciechanowska
U
U
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001215:Asparaginase / Q000008:administration & dosage; D001853:Bone Marrow / Q000187:drug effects* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D003630:Daunorubicin / Q000008:administration & dosage; D004912:Erythrocytes / Q000187:drug effects* / Q000648:ultrastructure; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D007223:Infant; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects* / Q000648:ultrastructure; D015162:Micronucleus Tests; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D011241:Prednisone / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage; D017086:beta-Thalassemia / Q000097:blood / Q000139:chemically induced* / Q000473:pathology
D014750:Vincristine; D001215:Asparaginase; D011241:Prednisone; D003630:Daunorubicin
Niedokrwistości i wznowy szpikowe w ostrej białaczce limfoblastycznej u dzieci po zakończeniu leczenia a czestość wystepowania erytroblastów z mikrojadrami.