title: Confocal analysis of fluorescent bead uptake by mouse Peyer's patch follicle-associated M cells.
abstract: Latex beads coated with secretory immunoglobulin (IgA) instilled into mouse intestinal loops are taken up by M cells present in Peyer's patch follicle-associated epithelial tissue. Bead adsorption and uptake is greater at the edge compared with the apex of follicle domes. Coating beads with bovine serum albumin (BSA) causes a fourfold reduction in adsorption and a twentyfold reduction in uptake. Results demonstrate selectivity between adsorption and uptake and between the ability of different proteins to facilitate uptake.
authors: Dipartimento di Fisiologia e Biochimica Generali, Universita degli Studi di Milano, Italy.
authors: C
authors: C
authors: Porta
authors: P S
authors: PS
authors: James
authors: A D
authors: AD
authors: Phillips
authors: T C
authors: TC
authors: Savidge
authors: M W
authors: MW
authors: Smith
authors: D
authors: D
authors: Cremaschi
mesh_terms: D000327:Adsorption; D000818:Animals; D005453:Fluorescence; D007071:Immunoglobulin A, Secretory / Q000378:metabolism; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010581:Peyer's Patches / Q000166:cytology / Q000378:metabolism*
chemical_list: D007071:Immunoglobulin A, Secretory