[Use of gamma-aminobutyric acid from various sources in the synthesis of homocarnosine in the brain of animals of various ages].
The dynamics and intensity of radiolabelled carbon incorporation from [14C] putrescine into homocarnosine in the brains of rats of various age have been studied. In the brains of 1-, 7-, and 2-day-old rats putrescine is the main GABA source for homocarnosine synthesis. In the brains of 14- and 31-day-old animals the GABA formed from glutamic acid participates in homocarnosine synthesis alongside with putrescine. In the brains of adult rats the rate of [14C] incorporation from glutamic acid into homocarnosine is 7 times as low as that of [14C] incorporation from putrescine.
Makletsova
M G
MG
Uskova
N I
NI
Bondarenko
T I
TI
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002250:Carbon Radioisotopes; D002336:Carnosine / Q000031:analogs & derivatives* / Q000096:biosynthesis; D011700:Putrescine / Q000378:metabolism; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D002250:Carbon Radioisotopes; C005038:homocarnosine; D005680:gamma-Aminobutyric Acid; D002336:Carnosine; D011700:Putrescine
Ispol'zovanie razlichnykh istochnikov gamma-aminomaslianoĭ kisloty v sinteze gomokarnozina v mozga zhivotnykh raznogo vozrasta.