Potential role of HBGF (FGF) and TGF-beta on prostate growth.
We review in this paper the role of heparin-binding growth factor (HBGF*) or fibroblast growth factor (FGF*), rat prostate cancer cells produce TGF-beta, IGF-II* and OGF*. Of these growth factors, TGF-beta and unknown labile factor with 19 kDa are the most probable candidates responsible for osteoblastic bony metastasis of prostate cancer. In vitro experiments suggest that TGF-beta modulates cell detachment of prostate cancer cells together with nutritional factors. HBGF-dependent growth of the prostate tumor epithelial cells is free from inhibition by TGF-beta, whereas normal prostate epithelial cells are sensitive to TGF-beta inhibition. Transfection experiments suggest that HBGF-2 (basic FGF) might be closely related to the malignant growth of prostate cancer, in addition to tumor angiogenesis.
Matuo
Y
Y
W. Alton Jones Cell Science Center, Lake Placid, NY 12946.
McKeehan
W L
WL
Yan
G C
GC
Nikolaropoulos
S
S
Adams
P S
PS
Fukabori
Y
Y
Yamanaka
H
H
Gaudreau
J
J
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D005346:Fibroblast Growth Factors / Q000096:biosynthesis / Q000494:pharmacology / Q000502:physiology*; D005347:Fibroblasts / Q000378:metabolism; D006133:Growth Substances / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000096:biosynthesis / Q000502:physiology; D008297:Male; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000302:isolation & purification / Q000502:physiology*; D010006:Osteoblasts / Q000187:drug effects / Q000473:pathology; D011467:Prostate / Q000166:cytology*; D011471:Prostatic Neoplasms / Q000473:pathology*; D051381:Rats; D014162:Transfection; D016212:Transforming Growth Factor beta / Q000096:biosynthesis / Q000494:pharmacology / Q000502:physiology*; D014407:Tumor Cells, Cultured
D006133:Growth Substances; D009363:Neoplasm Proteins; D016212:Transforming Growth Factor beta; D005346:Fibroblast Growth Factors; D007335:Insulin-Like Growth Factor II