The structure and expression of the genes for T-kininogen in the rat.
T-kininogen plays an important role in the acute phase response to trauma in the rat as a possible source of kinins and as a cysteine proteinase inhibitor. Two T-kininogens are expressed by rat liver from two separate genes. T-kininogen expression in liver during the acute phase response is regulated at the level of transcription. The similarity in T- and K-kininogen gene structure suggests divergent evolution from a common gene ancestor.
Cole
T J
TJ
Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria, Australia.
Schreiber
G
G
D000210:Acute-Phase Reaction / Q000235:genetics; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D015870:Gene Expression; D007704:Kininogens / Q000235:genetics*; D008099:Liver / Q000378:metabolism; D008969:Molecular Sequence Data; D005810:Multigene Family; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats
D007704:Kininogens; D012333:RNA, Messenger; D004247:DNA