[Changes in the phagocytic activity of macrophages under the action of different doses of antibiotics].
Penicillin, streptomycin and gentamicin, when introduced into mice in a single injection in doses of 0.5-500,000 U/kg, produced different changes in the phagocytic activity of mouse peritoneal macrophages. Bactericidal doses of these antibiotics either suppressed the activity of macrophages or left it unchanged. Their sub-bactericidal doses enhanced the phagocytic activity of macrophages. Combined use of penicillin and streptomycin produced a synergic effect.
Aprikian
V S
VS
Mikhaĭlova
A A
AA
Petrov
R V
RV
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005839:Gentamicins / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010400:Penicillin G / Q000494:pharmacology; D010529:Peritoneal Cavity / Q000166:cytology; D010587:Phagocytosis / Q000187:drug effects*; D013211:Staphylococcus aureus; D013307:Streptomycin / Q000494:pharmacology; D013997:Time Factors
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010400:Penicillin G; D013307:Streptomycin
Izmenie fagotsitarnoĭ aktivnosti makrofagov pod deĭstviem razlichnykh doz antibiotikov.