[Laboratory problems of chemotherapy of viral infections in humans].
The following problems are presented and discussed: scientific and epidemiologic basis of chemotherapy, relations of antiviral activity in vitro and in vivo especially important when new-drugs are developed and evaluated, inhibitors used in medical treatment and mechanisms of their antiviral functions, genesis and nature of virus resistance, possible role of interfering defective particles. The paper is addressed both to laboratories involved in new drugs construction as well to clinical ones performing etiologic diagnostic procedures.
Kańtoch
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Zakład Wirusologii Państwowego Zakładu Higieny, Warszawie.
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000382:microbiology; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D006224:Cricetinae; D004195:Disease Models, Animal; D006168:Guinea Pigs; D015497:HIV-1 / Q000187:drug effects; D006509:Hepatitis B / Q000188:drug therapy / Q000382:microbiology; D006515:Hepatitis B virus / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D009980:Influenza A virus / Q000187:drug effects; D007251:Influenza, Human / Q000188:drug therapy / Q000382:microbiology; D051379:Mice; D051381:Rats; D012136:Respiratory Syncytial Viruses / Q000187:drug effects; D010253:Respirovirus Infections / Q000188:drug therapy / Q000382:microbiology; D014777:Virus Diseases / Q000188:drug therapy* / Q000382:microbiology
D000998:Antiviral Agents
Laboratoryjne problemy chemioterapii zakazeń wirusowych człowieka.