Pokeweed antiviral protein: ribosome inactivation and therapeutic applications.
Pokeweed antiviral protein (PAP) is a ribosome-inactivating protein (RIP) that inactivates ribosomes by the removal of a single adenine from ribosomal RNA. The studies summarized in our review concern the nature and application of this novel therapeutic agent. We describe how researchers continue to elucidate the structure and biologic activity of RIPs. Pokeweed antiviral protein is among the RIPs that have been conjugated to selective monoclonal antibodies for the treatment of several human cancers and viral diseases. Clinical trials using PAP immunotoxins for the treatment of leukemia have been particularly encouraging.
Irvin
J D
JD
Department of Chemistry, Southwest Texas State University, San Marcos 78666.
Uckun
F M
FM
D000595:Amino Acid Sequence; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000009:adverse effects / Q000627:therapeutic use*; D006678:HIV / Q000187:drug effects*; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D008969:Molecular Sequence Data; D009699:N-Glycosyl Hydrolases; D010940:Plant Proteins / Q000009:adverse effects / Q000627:therapeutic use*; D012339:RNA, Ribosomal, 28S / Q000187:drug effects*; D054789:Ribosome Inactivating Proteins, Type 1; D013329:Structure-Activity Relationship
D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; D010940:Plant Proteins; D012339:RNA, Ribosomal, 28S; D054789:Ribosome Inactivating Proteins, Type 1; D009699:N-Glycosyl Hydrolases; C024275:pokeweed antiviral protein