title: Median effective dosage of propofol for induction of anesthesia in dogs.
abstract: The median effective dosage (ED50) of propofol for induction of anesthesia was determined in 25 dogs premedicated with acepromazine, 0.05 mg/kg of body weight, and in 35 unpremedicated dogs. The ED50 was found to be 2.2 mg/kg in premedicated dogs and was 3.8 mg/kg in unpremedicated dogs. The mean +/- SD total dosage of propofol required to induce anesthesia in premedicated animals was 2.8 +/- 0.5 mg/kg and was 4.7 +/- 1.3 mg/kg in unpremedicated animals. Signs of excitement were observed in 5 of the unpremedicated dogs, but in none of those that were premedicated.
authors: Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0136.
authors: G C
authors: GC
authors: Watney
authors: L S
authors: LS
authors: Pablo
mesh_terms: D000075:Acepromazine / Q000008:administration & dosage; D000771:Anesthesia, Intravenous / Q000662:veterinary*; D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D007273:Injections, Intramuscular / Q000662:veterinary; D008297:Male; D011229:Preanesthetic Medication / Q000662:veterinary; D015742:Propofol / Q000008:administration & dosage*
chemical_list: D000075:Acepromazine; D015742:Propofol