title: [The electron-histochemical detection of the activity of thiol proteinases in normal and cirrhotically altered liver].
abstract: The distribution co-activity of thiol proteinases (cathepsin B and cathepsin H) was investigated in normal and cirrhotic liver by the electron-cytochemical method. The reaction product was localized on lysosomes of Kupffer's cells, hepatocytes, endotheliocytes and fibroblasts. Extracellular activity of thiol proteinases was revealed in normal as well as in cirrhotic liver. The reaction product was situated on collagen fibrils near hepatocytes and connective tissue cells. The results evidence that besides participation in intracellular degradation of different proteins, thiol proteinases are secreted by hepatocytes and connective tissue cells of the liver to the intercellular space and can take part in extracellular collagen resorption.
authors: V V
authors: VV
authors: Ryvniak
authors: V S
authors: VS
authors: Gudumak
authors: E S
authors: ES
authors: Onia
mesh_terms: D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000150:complications / Q000201:enzymology / Q000473:pathology; D002401:Cathepsin B / Q000378:metabolism; D056655:Cathepsin H; D002403:Cathepsins / Q000378:metabolism; D003094:Collagen / Q000378:metabolism; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D006651:Histocytochemistry; D008099:Liver / Q000201:enzymology* / Q000648:ultrastructure; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000201:enzymology* / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D051381:Rats
chemical_list: D003094:Collagen; D002403:Cathepsins; D003546:Cysteine Endopeptidases; D002401:Cathepsin B; D056655:Cathepsin H; C534128:Ctsh protein, rat
vernacular_title: Elektronno-gistokhimicheskoe vyiavlenie aktivnosti tiolovykh proteinaz v normal'noĭ i tsirroticheski izmenennoĭ pecheni.