title: Metabolism of 16 alpha-hydroxytestosterone by cytochrome P-450 in rat liver.
abstract: The metabolism of 16 alpha-hydroxytestosterone by cytochrome P-450 system was studied with two different inductions. At least 5 different metabolites with higher polarity were produced from 16 alpha-hydroxytestosterone. MT-B, one of their products, appeared to be specifically increased by 3-methylcholanthrene- and phenobarbital-inducible P-450, respectively. This suggests that monohydroxylated testosterones are further metabolized by the P-450 system and that the reactions are isozyme specific. This can contribute at least in part to the diversity of steroid metabolism by P-450.
authors: Laboratory of Biochemistry, Korea Ginseng and Tobacco Research Institute, Taejon.
authors: H B
authors: HB
authors: Lim
authors: H O
authors: HO
authors: Sohn
authors: Y G
authors: YG
authors: Lee
authors: D W
authors: DW
authors: Lee
mesh_terms: D000818:Animals; D002855:Chromatography, Thin Layer; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000378:metabolism*; D004790:Enzyme Induction; D006915:Hydroxytestosterones / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013379:Substrate Specificity
chemical_list: D006915:Hydroxytestosterones; C045261:16-hydroxytestosterone; D003577:Cytochrome P-450 Enzyme System