Calcitonin effects on rabbit bone. Bending tests on ulnar osteotomies.
30 adult male New Zealand white rabbits underwent osteotomy and plate fixation of the left ulna for 6 or 12 weeks. The right ulna served as control. In half of the rabbits 6 IU calcitonin was given daily until death, and in the other half placebo injections in the same manner. A three-point bending test was performed on both ulnae. Sections of bone, covered or uncovered by the plates, were examined histologically. Long-term administration of calcitonin increased the mechanical properties of both fractured and intact bones and reduced porosity of the cortex under the plate.
Karachalios
T
T
Athens University Th. Garofalidis Research Center, Orthopedic Department, Kat Hospital, Kifisia, Greece.
Lyritis
G P
GP
Giannarakos
D G
DG
Papanicolaou
G
G
Sotopoulos
K
K
D000818:Animals; D001696:Biomechanical Phenomena; D001860:Bone Plates; D016723:Bone Remodeling / Q000187:drug effects*; D001842:Bone and Bones / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D002116:Calcitonin / Q000494:pharmacology*; D004548:Elasticity / Q000187:drug effects; D005593:Fracture Fixation, Internal; D006253:Haversian System / Q000473:pathology; D066298:In Vitro Techniques; D008297:Male; D010027:Osteotomy; D011817:Rabbits; D014458:Ulna Fractures / Q000473:pathology / Q000503:physiopathology / Q000628:therapy
D002116:Calcitonin