Approach to the sterilization with gamma rays of a drug. Note I: Treatment technique and effects at zero time.
Authors, considering a possible use of the sterilizing treatment with gamma rays for the productive process of a drug, performed a series of practical treatment tests. To this purpose, they used a single molecule, stable in time and with an easy analytical approach. The examined active principle is the injectable salt of acetylcarnitine chloride. For tests, they used irradiating doses by 2.5-5.0-7.5 Mrads in order to point out the process possible effects. The treatment, even at highest dosages, did not show damages to the molecule that could prevent from going on with the investigation.
Matteucci
P
P
Siena University, Technological Pharmaco/Chemical Department.
Celletti
P
P
Picello
G
G
Lencioni
E
E
Franchi
G
G
D000108:Acetylcarnitine / Q000032:analysis / Q000528:radiation effects; D002851:Chromatography, High Pressure Liquid; D005720:Gamma Rays; D013242:Sterilization
D000108:Acetylcarnitine