title: Local perineal implants of anti-androgen block masculinization of the spinal nucleus of the bulbocavernosus.
abstract: Female rats were injected with testosterone propionate on the 1st and 3rd days of life. In addition, some females received 200 micrograms of the anti-androgen, hydroxyflutamide. Females receiving anti-androgen directly to the perineum, including the muscles bulbocavernosus and levator ani, had fewer surviving spinal nucleus of the bulbocavernosus (SNB) motoneurons than did females receiving the anti-androgen systemically. These results indicate that androgen acts upon the target muscles to spare developing SNB motoneurons from death.
authors: Department of Psychology, University of California, Berkeley 94720.
authors: R B
authors: RB
authors: Fishman
authors: S M
authors: SM
authors: Breedlove
mesh_terms: D000818:Animals; D005314:Embryonic and Fetal Development / Q000187:drug effects; D005260:Female; D005485:Flutamide / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D007267:Injections; D009046:Motor Neurons / Q000166:cytology / Q000502:physiology; D009132:Muscles / Q000294:innervation; D010502:Perineum; D051381:Rats; D012733:Sex Differentiation / Q000187:drug effects*; D013116:Spinal Cord / Q000166:cytology / Q000196:embryology*; D013739:Testosterone / Q000008:administration & dosage
chemical_list: C014290:hydroxyflutamide; D013739:Testosterone; D005485:Flutamide