NG-011 and NG-012, novel potentiators of nerve growth factor. I. Taxonomy, isolation, and physico-chemical and biological properties.
NG-011 and NG-012, novel potentiators of nerve growth factor (NGF), were isolated from the culture broth of Penicillium verruculosum F-4542, together with 3,4-dihydro-6,8-dihydroxy-3-methylisocoumarin. They potentiated the neurite outgrowth induced by NGF in rat pheochromocytoma cell line (PC12).
Ito
M
M
Research Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Maruhashi
M
M
Sakai
N
N
Mizoue
K
K
Hanada
K
K
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D049934:Isocoumarins; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009414:Nerve Growth Factors / Q000494:pharmacology*; D016501:Neurites / Q000187:drug effects*; D016716:PC12 Cells; D010407:Penicillium / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats
D000900:Anti-Bacterial Agents; D003374:Coumarins; D049934:Isocoumarins; D007783:Lactones; D009414:Nerve Growth Factors; D010636:Phenols; C078926:NG 011; C070622:6-hydroxymellein