title: Effects of TRH-T on spinal motoneurones in man.
abstract: The effect of thyrotropin-releasing hormone tartrate (TRH-T) on the decrease in H Max/M Max ratio, an index of the spinal motoneurone pool, induced by haloperidol, was studied in 15 healthy volunteers. In all subjects, the H response was examined by an electromyographic apparatus. The values were expressed as H Max/M Max ratio, that gives an index of excitability of the spinal motoneurone pool. It was found that the mean H Max/M Max ratio value significantly decreased after haloperidol administration, but this effect was completely reversed by the injection of TRH-T. This finding suggests that the peptide may modulate motoneurone functions.
authors: Institute of Clinical Neurology, University of Catania Medical School, Italy.
authors: R
authors: R
authors: Raffaele
authors: E
authors: E
authors: Cosentino
authors: M B
authors: MB
authors: Anicito
authors: A
authors: A
authors: Sciacca
authors: L
authors: L
authors: Rampello
authors: G
authors: G
authors: Pennisi
authors: A A
authors: AA
authors: Genazzani
authors: G
authors: G
authors: Bosco
authors: A
authors: A
authors: Casabona
authors: F
authors: F
authors: Drago
mesh_terms: D000328:Adult; D005260:Female; D006181:H-Reflex / Q000187:drug effects; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000187:drug effects*; D013116:Spinal Cord / Q000166:cytology* / Q000187:drug effects; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
chemical_list: D013973:Thyrotropin-Releasing Hormone; D006220:Haloperidol