[Malignant endocrine tumor of the pancreas associated with high blood thyrocalcitonin levels].
A case of thyrocalcitonin-secreting endocrine tumour of the pancreas is reported. Endocrine pancreatic tumours are neoplasias evolving over a long period; most of them are multisecreting, usually with a predominant secretion responsible for clinical symptoms. In this particular case the retrospective diagnosis of a thyrocalcitonin-secreting tumour of the pancreas was made by immunocytochemical study of the pancreatectomy specimen. One year after pancreatectomy, the persistence of clinical signs and a plasma thyrocalcitonin level higher than 25,000 pg/ml led to the discovery of a liver metastasis. An immunocytochemical study of the segmental hepatectomy specimen showed a single population of thyrocalcitonin-secreting cells identical with those found in the pancreatic tumour. In this context, radioimmunological assays of peptides and immunocytochemistry seem to be the best diagnostic methods.
Doullay
F
F
Service d'Endocrinologie et Maladies métaboliques, Hôpital de la Conception, Marseille.
Bricot
R
R
Dor
A M
AM
Chayvialle
J A
JA
Berger
F
F
Conte-Devolx
B
B
D000368:Aged; D002116:Calcitonin / Q000032:analysis*; D002277:Carcinoma / Q000097:blood* / Q000473:pathology / Q000601:surgery; D003537:Cystadenoma / Q000097:blood* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery
D002116:Calcitonin
Tumeur maligne endocrine du pancréas associée à des taux sériques élevés de thyrocalcitonine.