[The effect of dalargin on the hemodynamics in acute myocardial infarct complicated by clinical death].
Cardiac output and myocardial contractility have been studied in dogs with experimental myocardial infarction complicated by 5 min clinical death. Control animals (16 dogs) were intravenously injected physiologic saline, while test animals (12 dogs) were administered leu-enkephalin analogue dalargin at a dose of 100 micrograms/kg, 20 min and 6-h after recovery. It has been established that dalargin improved basic hemodynamic parameters due to normalization of cardiac contractility, arrhythmia removal and reduction of the peripheral resistance. The data obtained make it possible to recommend dalargin for combined therapy of postresuscitation hemodynamic disturbances in acute myocardial infarction.
Lisachenko
G V
GV
Slepushkin
V D
VD
Zoloev
G K
GK
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D003643:Death; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography / Q000187:drug effects; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006324:Heart Arrest, Induced; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D012151:Resuscitation; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Vliianie dalargina na gemodinamiku pri ostrom infarkte miokarda, oslozhnennom klinicheskoĭ smert'iu.