Intensive radio-chemotherapy with peripheral blood stem cell transplantation in young patients with chronic lymphocytic leukemia.
Two patients with previously treated CLL received autologous PBSC transplantation after total body irradiation and high-dose chemotherapy. Before intensification, a partial marrow response had been obtained in both patients, with disappearance of peripheral blood involvement as shown by immunophenotypic assessment using fludarabine. PBSC collection was performed after a single course of high-dose cyclophosphamide followed by GM-CSF administration. One patient failed to reconstitute normal hematopoiesis and died 3 months post-transplant. The other is in continuous complete remission 12 months after intensification. This strategy in young patients with poor prognosis CLL warrants further investigation.
Bastion
Y
Y
Service d'Hématologie, Centre Hospitalier Lyon-Sud, Pierre-Bénite, France.
Felman
P
P
Dumontet
C
C
Espinouse
D
D
Coiffier
B
B
D000328:Adult; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy* / Q000532:radiotherapy* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D033581:Stem Cell Transplantation; D014916:Whole-Body Irradiation
D003520:Cyclophosphamide