title: Acquired heterochromia with horner syndrome in two adults.
abstract: BACKGROUND
  Heterochromia iridis, asymmetry of iris pigmentation, has been well described with congenital Horner syndrome. Acquired heterochromia associated with lesions in the ocular sympathetic pathways in adulthood, however, is rare.
  
  
  METHODS
  Two cases are reported in which sympathectomy in adults resulted in ipsilateral Horner syndrome with heterochromia. In each case, pharmacologic testing with cocaine and hydroxyamphetamine was performed.
  
  
  RESULTS
  In both cases, sympathectomy occurred at the level of the second order neuron, but hydroxyamphetamine testing suggested at least partial third order neuron involvement.
  
  
  CONCLUSIONS
  Acquired heterochromia can occur in adults. The partial response to hydroxyamphetamine in the two cases presented may reflect trans-synaptic degeneration of the postganglionic neuron. A reduction in trophic influences on iris melanocytes may have contributed to the observed heterochromia.
authors: Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA.
authors: M C
authors: MC
authors: Diesenhouse
authors: D A
authors: DA
authors: Palay
authors: N J
authors: NJ
authors: Newman
authors: K
authors: K
authors: To
authors: D M
authors: DM
authors: Albert
mesh_terms: D000368:Aged; D005260:Female; D006732:Horner Syndrome / Q000150:complications*; D006801:Humans; D007500:Iritis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010859:Pigmentation Disorders / Q000209:etiology*; D011680:Pupil / Q000187:drug effects; D013562:Sympathectomy / Q000009:adverse effects; D013564:Sympathetic Nervous System / Q000293:injuries