Lymphocyte-predominance Hodgkin's disease.
Nodular lymphocyte-predominance Hodgkin's disease (NLPHD) has emerged as a distinct entity. It has a precursor lesion, known as follicular hyperplasia with progressively transformed germinal centers (PTGC), and a late stage consisting of transformation to a large cell lymphoma. All cellular components of NLPHD are derived from follicles, but so far no clonal population has been identified.
Poppema
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Department of Laboratory Medicine, Cross Cancer Institute, Edmonton, Alberta, Canada.
D001402:B-Lymphocytes / Q000276:immunology; D006689:Hodgkin Disease / Q000145:classification / Q000150:complications / Q000276:immunology / Q000473:pathology*; D006801:Humans; D016130:Immunophenotyping; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology; D008297:Male; D016539:Reed-Sternberg Cells / Q000473:pathology; D012727:Sex Characteristics; D013601:T-Lymphocytes / Q000276:immunology