title: Peptides and exercise at high and low altitudes.
abstract: Some peptides are released with stress. We therefore examined effects of different exercise stress at low and moderate altitudes and after heat stress on beta-endorphin and endothelin in the human circulation. We also assessed longitudinally the effects of chronic exertion on beta-endorphin and the relationship to melatonin secretion in well-trained athletes. All peptides and melatonin increased after exercise, but the magnitude of this increase was age-dependent. Chronic exertion is associated with a decrease in exercise induced opioid release and in such individuals melatonin secretion is not beta-endorphin related. Long term high altitude exposure is associated with high-beta-endorphin levels at rest. Atrial natriuretic factor and vasopressin is also released with exercise at moderate altitude. Endothelin, a powerful vasoconstrictor, is increased independent of type of exercise, duration and moderate hypoxia.
authors: Lovelace Medical Foundation, Center for Basic and Applied Medical Research, Albuquerque, New Mexico 87108.
authors: O
authors: O
authors: Appenzeller
authors: S C
authors: SC
authors: Wood
mesh_terms: D000328:Adult; D000367:Age Factors; D000531:Altitude; D016232:Endothelins / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005260:Female; D006358:Hot Temperature / Q000009:adverse effects; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008550:Melatonin / Q000378:metabolism; D009390:Nepal; D009516:New Mexico; D010455:Peptides / Q000097:blood*; D010806:Physical Education and Training / Q000379:methods; D010807:Physical Endurance / Q000502:physiology; D012420:Running / Q000502:physiology; D001615:beta-Endorphin / Q000097:blood
chemical_list: D016232:Endothelins; D010455:Peptides; D001615:beta-Endorphin; D008550:Melatonin