The effect of tolbutamide on burn hypermetabolism.
The effect of tolbutamide on improving burn hypermetabolism was studied prospectively in 31 burn adults with total body surface area burned > 40 per cent and 18 burned rabbits immediately after burn injury to postburn day 10. The results showed that burn hypermetabolism could be reduced using tolbutamide, which may be the result of the correction of relative insulin insufficiency, tissue insulin resistance and improving glucose utilization.
Xie
W
W
Burn Research Institute, Southwestern Hospital, Third Military Medical College, Chongqing, China.
Li
A
A
Wang
S
S
D000328:Adult; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002056:Burns / Q000378:metabolism*; D004734:Energy Metabolism; D005260:Female; D005934:Glucagon / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D010101:Oxygen Consumption; D011446:Prospective Studies; D011817:Rabbits; D014044:Tolbutamide / Q000008:administration & dosage / Q000627:therapeutic use*
D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon; D014044:Tolbutamide