Molecular design of biologically active compounds based on platelet activating factor (PAF): 7-oxabicyclo[2.2.1]heptane system as a strong antagonist of PAF.
7-Oxabicyclo[2.2.1]heptane system was designed based on the PAF structure. Among four stereoisomers synthesized, the diexo derivative turned out to be a new and strong antagonist of PAF.
Kobayashi
S
S
Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Eguchi
Y
Y
Sato
M
M
Kudo
I
I
Inoue
K
K
Ohno
M
M
D015195:Drug Design; D006536:Heptanes / Q000138:chemical synthesis* / Q000494:pharmacology; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry*; D013329:Structure-Activity Relationship
D006536:Heptanes; D010972:Platelet Activating Factor; D010975:Platelet Aggregation Inhibitors