Effect of various microbial preparations on P-388 mouse lymphocytic leukemia.
Four bacteria-derived immunopotentiators were tested for their protective effect on a P-388 mouse lymphocytic leukemia model. The microbial test products were prepared from the following bacterial strains: ATCC 35983 Staphylococcus epidermidis isolated from a patient with IV catheter; ATCC 31874, a patented strain listed as Staphylococcus epidermidis isolated from the urine of a cancer patient; ATCC 25615 Staphylococcus hominis obtained from a child with lymphocytic leukemia, and ATCC 25614 Staphylococcus warneri, an isolate from a patient with adenocarcinoma of the breast. A limited degree of protection and prolongation in survival time was observed in the animal group treated with the bacterial strain ATCC 31874.
Antoun
M D
MD
Department of Pharmaceutical Sciences, School of Pharmacy, UPR, San Juan 00936-5067.
Caballero
R
R
Robledo
I
I
Lavergne
J
J
D000276:Adjuvants, Immunologic / Q000096:biosynthesis / Q000627:therapeutic use*; D000818:Animals; D007167:Immunotherapy / Q000379:methods; D007941:Leukemia P388 / Q000276:immunology / Q000628:therapy*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013210:Staphylococcus / Q000254:growth & development* / Q000378:metabolism; D013212:Staphylococcus epidermidis / Q000254:growth & development* / Q000378:metabolism
D000276:Adjuvants, Immunologic