Steroid research at Syntex: "the pill" and cortisone.
The period from late 1949 through 1951 was an extraordinarily productive one in steroid chemistry and especially so at Syntex S.A. in Mexico City. Two of the most important Syntex contributions--the synthesis of 19-nor-17 alpha-ethynyltestosterone (norethindrone) and of cortisone from diosgenin--are described from a historical perspective.
Djerassi
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Department of Chemistry, Stanford University, California 94305-5080.
D003278:Contraceptives, Oral, Hormonal / Q000138:chemical synthesis / Q000737:chemistry; D003348:Cortisone / Q000138:chemical synthesis / Q000737:chemistry; D004144:Diosgenin / Q000737:chemistry; D004345:Drug Industry / Q000266:history*; D049673:History, 20th Century; D006801:Humans; D008800:Mexico; D009640:Norethindrone / Q000138:chemical synthesis; D013678:Technology, Pharmaceutical / Q000266:history*
D003278:Contraceptives, Oral, Hormonal; D004144:Diosgenin; D009640:Norethindrone; D003348:Cortisone