title: Inhaled natural human interferon alpha induces bronchospastic reactions in asthmatics.
abstract: There is a relationship between viral infection and aggravation of bronchial asthma symptoms. Viruses belong to the strongest and fast acting inducers of interferon (IFN), which, in turn, may enhance histamine release from effector cells. We have administered IFN intrabronchially to 49 patients suffering from bronchial asthma. The impairment of lung ventilation with significant decrease of forced expiratory volume in one second (FEV1) have been observed in majority of the patients who inhaled crude or purified IFN preparations.
authors: Department of Internal Disease and Allergology, University Medical School, Wrocław, Poland.
authors: M
authors: M
authors: Krasnowska
authors: J
authors: J
authors: Małolepszy
authors: E
authors: E
authors: Liebhart
authors: A D
authors: AD
authors: Inglot
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D001249:Asthma / Q000503:physiopathology*; D001986:Bronchial Spasm / Q000139:chemically induced*; D016084:Bronchoconstriction / Q000187:drug effects; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects* / Q000494:pharmacology; D007428:Intradermal Tests; D008297:Male; D008875:Middle Aged
chemical_list: D016898:Interferon-alpha