Metabolism of 16 alpha-hydroxytestosterone by cytochrome P-450 in rat liver.
The metabolism of 16 alpha-hydroxytestosterone by cytochrome P-450 system was studied with two different inductions. At least 5 different metabolites with higher polarity were produced from 16 alpha-hydroxytestosterone. MT-B, one of their products, appeared to be specifically increased by 3-methylcholanthrene- and phenobarbital-inducible P-450, respectively. This suggests that monohydroxylated testosterones are further metabolized by the P-450 system and that the reactions are isozyme specific. This can contribute at least in part to the diversity of steroid metabolism by P-450.
Lim
H B
HB
Laboratory of Biochemistry, Korea Ginseng and Tobacco Research Institute, Taejon.
Sohn
H O
HO
Lee
Y G
YG
Lee
D W
DW
D000818:Animals; D002855:Chromatography, Thin Layer; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000378:metabolism*; D004790:Enzyme Induction; D006915:Hydroxytestosterones / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013379:Substrate Specificity
D006915:Hydroxytestosterones; C045261:16-hydroxytestosterone; D003577:Cytochrome P-450 Enzyme System