title: Studies on the synthesis of sesquiterpene lactones, 14. Syntheses of (-)-arbusclin D and (+)-4-EPI-arbusclin D: the stereochemical assignment of arbusclin D.
abstract: Efficient syntheses of (-)-arbusclin D and (+)-4-epi-arbusclin D are reported. By these syntheses the C-4 stereochemistry of arbusclin D and the absolute configuration of (-)-arbusclin D have been determined to be a s shown in structure 1. The biological activities, such as cytotoxic activity toward P-388 lymphocytic leukemia, plant growth regulating activity, and antimicrobial activity of compounds 1, 3, 7, 9, 12, and 14 were also studied.
authors: Department of Applied Chemistry, Faculty of Engineering, Niigata University, Japan.
authors: M
authors: M
authors: Ando
authors: K
authors: K
authors: Isogai
authors: H
authors: H
authors: Azami
authors: N
authors: N
authors: Hirata
authors: H
authors: H
authors: Yamazaki
authors: Y
authors: Y
authors: Yanagi
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000737:chemistry*; D007783:Lactones / Q000138:chemical synthesis* / Q000494:pharmacology; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D010937:Plant Growth Regulators / Q000494:pharmacology; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000494:pharmacology; D045787:Sesquiterpenes, Eudesmane
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D010937:Plant Growth Regulators; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane; C079190:arbusclin D