[Synthesis and radiosensitizing activity of nitro-arylimino-diethyl-sodium thiosulfate and nitro phenylalanine derivatives].
A series of compounds was synthesized, these compounds were tested for Hela-S3 cells in vitro for radiosensitizing activity. Five of them are 2,2'-(arylimino)-diethyl-sodium thiosulfate and two of them are phenylalanine derivatives. Most of them showed various degrees of radiosensitizing activity. Among them, SER of L07 was 1.89 at 3 mmol, and had low cytotoxicity to Hela-S3 cells, ID50 was 18.8 mmol. The relationship between radiosensitizing effects and chemical structure was discussed. It offers a base for further exploration of selectively hypoxic cell radiosensitizers.
Liu
H X
HX
Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin.
Hu
B
B
Li
Z
Z
Mi
F S
FS
Shen
Y
Y
D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D009578:Nitrobenzenes / Q000138:chemical synthesis*; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D011838:Radiation-Sensitizing Agents / Q000138:chemical synthesis* / Q000494:pharmacology
D009578:Nitrobenzenes; D011838:Radiation-Sensitizing Agents; D010649:Phenylalanine