title: Developmental changes in distribution of NMDA receptor channel subunit mRNAs.
abstract: In situ hybridization analyses have revealed drastic changes in expression and distribution of five subunit mRNAs of the mouse NMDA receptor channel during brain development. The epsilon 1 subunit mRNA is expressed postnatally and widely in the brain. On the other hand, the epsilon 2 subunit mRNA is found throughout the entire embryonic brain, but its expression becomes restricted to the forebrain at postnatal stages. The epsilon 3 subunit mRNA appears postnatally and predominantly in the cerebellum, whereas the epsilon 4 subunit mRNA is abundantly expressed in the diencephalon and the brainstem at embryonic and neonatal stages. In contrast, the zeta 1 subunit mRNA distributes ubiquitously in the brain throughout development. These findings suggest that changes in the subunit composition of the NMDA receptor channel take place during brain development.
authors: Department of Anatomy, Hokkaido University School of Medicine, Sapporo, Japan.
authors: M
authors: M
authors: Watanabe
authors: Y
authors: Y
authors: Inoue
authors: K
authors: K
authors: Sakimura
authors: M
authors: M
authors: Mishina
mesh_terms: D000818:Animals; D001921:Brain / Q000254:growth & development*; D001923:Brain Chemistry / Q000502:physiology; D005260:Female; D017403:In Situ Hybridization; D051379:Mice; D008810:Mice, Inbred C57BL; D009841:Oligonucleotides; D011247:Pregnancy; D015347:RNA Probes; D012333:RNA, Messenger / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*
chemical_list: D009841:Oligonucleotides; D015347:RNA Probes; D012333:RNA, Messenger; D016194:Receptors, N-Methyl-D-Aspartate