[Matrix effects from the thanatochemical viewpoint].
The predominating hydrophilic physiological body constituents are not interfering severely during the toxicological analysis for organic poisons in biological matrices, whereas coextracted lipids are usually well distinguishable from xenobiotics. But interfering substances increase strongly with autolysis, and some of them behave like toxicologically relevant compounds to be detected by the respective analytical methods. Attempts are reaching from the STAS' isolation procedure through the ptomaines to our chromatographical epoche, to phenomenologically compensate the matrix effects--increasing in the course of putrefaction--by the determination and generalisation of according analytical signals. The paper outlines on the background of Systematic Toxicological Analysis how far a systematic thanatochemical concept should be considered more closely for the futural more effective analytical elimination of such matrix effects.
Müller
R K
RK
Institut für Gerichtliche Medizin, Universität Leipzig.
Wehran
H J
HJ
Hunger
H
H
Zschocke
D
D
D005109:Extracellular Matrix / Q000473:pathology*; D006801:Humans; D011041:Poisoning / Q000473:pathology*; D011042:Poisons; D011180:Postmortem Changes
D011042:Poisons
Matrixeffektive thanatochemisch betrachtet.