PRAD1 (cyclin D1): a parathyroid neoplasia gene on 11q13.
Hyperparathyroidism is a central component of multiple endocrine neoplasia type 1 (MEN 1), and both sporadic and familial forms of parathyroid disease may share certain pathogenetic features. We recently identified a gene that is clonally rearranged with the PTH locus in a subset of sporadic parathyroid adenomas. This candidate oncogene, PRAD1 (previously D11S287), appears to contribute to parathyroid tumorigenesis in a fashion analogous to activation of C-MYC or BCL-2 by rearrangement with tissue-specific enhancers of the immunoglobulin genes in B-lymphoid neoplasia. The PRAD1 gene maps to 11q13 and has been linked to the BCL-1 breakpoint locus, although not to the most tightly linked MEN 1 markers, by pulsed field gel electrophoresis. PRAD1 may, in fact, be the long-sought BCL-1 lymphoma oncogene. PRAD1 encodes a novel type of cyclin protein and thus may normally function in controlling the cell cycle, perhaps through direct interaction with cdc2 or a related kinase. PRAD1's possible primary, or more likely secondary, involvement in the pathogenesis of MEN 1-related tumors is unknown and under investigation.
Arnold
A
A
Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114.
Motokura
T
T
Bloom
T
T
Rosenberg
C
C
Bale
A
A
Kronenberg
H
H
Ruderman
J
J
Brown
M
M
Kim
H G
HG
D000595:Amino Acid Sequence; D002880:Chromosomes, Human, Pair 11; D016213:Cyclins / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D009857:Oncogenes / Q000235:genetics; D010282:Parathyroid Neoplasms / Q000235:genetics*
D016213:Cyclins