title: Chlorinated hydrocarbons in the bone marrow of children: studies on their association with leukaemia.
abstract: Concentrations of chlorinated hydrocarbons and polychlorinated biphenyls (PCB) were determined by capillary column gas chromatography in samples of bone marrow from 38 children with leukaemia (16 samples/pools) and 15 control (5 pools). The highest mean and median concentrations were detected for total PCB (mean = 3.568 mg/kg fat basis/median 2.904 mg/kg) followed by the sum of the dichlorodiphenyltrichloroethane metabolites (1.775/1.059 mg/kg), hexachlorobenzene 0.354/0.260 mg/kg), the sum of the hexachlorocyclohexane isomers (0.133/0.093 mg/kg) and dieldrin (0.109/0.063 mg/kg). The CHC and PCB concentrations in bone marrow were two- to threefold higher than in fat tissue. Comparing children with and without leukaemia similar concentrations of CHC and PCB were found.
authors: Children's Hospital Mannheim, University of Heidelberg, Federal Republic of Germany.
authors: J
authors: J
authors: Scheele
authors: M
authors: M
authors: Teufel
authors: K H
authors: KH
authors: Niessen
mesh_terms: D001853:Bone Marrow / Q000737:chemistry*; D016022:Case-Control Studies; D002648:Child; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000032:analysis*; D015470:Leukemia, Myeloid, Acute; D010575:Pesticides / Q000032:analysis; D011078:Polychlorinated Biphenyls / Q000032:analysis*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma
chemical_list: D006843:Hydrocarbons, Chlorinated; D010575:Pesticides; D011078:Polychlorinated Biphenyls