title: Fixed drug eruption of the scrotum due to methylphenidate.
abstract: OBJECTIVE
  To report two cases of fixed drug eruption induced by methylphenidate.
  
  
  METHODS
  Two children with attention deficit disorder treated with methylphenidate as a simple drug developed fixed drug eruption of the scrotum. Drug discontinuation was followed by a complete resolution of the skin eruption. Rechallenge resulted in the same drug rash. Macrophage migration-inhibiting factor (MIF) assay with methylphenidate was positive.
  
  
  CONCLUSIONS
  The pathogenesis of fixed drug eruption and the role of MIF assay in the diagnosis of adverse drug reaction is discussed.
  
  
  CONCLUSIONS
  Fixed drug rash induced by methylphenidate is a possible but rare phenomenon.
authors: Department of Pediatrics, Hasharon Hospital, Sackler School of Medicine, Tel Aviv University, Petach Tikvah, Israel.
authors: H A
authors: HA
authors: Cohen
authors: A
authors: A
authors: Ashkenazi
authors: M
authors: M
authors: Nussinovitch
authors: S
authors: S
authors: Gross
authors: M
authors: M
authors: Frydman
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy; D002648:Child; D003875:Drug Eruptions / Q000209:etiology*; D005832:Genital Diseases, Male / Q000139:chemically induced; D006801:Humans; D008263:Macrophage Migration-Inhibitory Factors / Q000032:analysis; D008297:Male; D008774:Methylphenidate / Q000009:adverse effects* / Q000627:therapeutic use; D012611:Scrotum
chemical_list: D008263:Macrophage Migration-Inhibitory Factors; D008774:Methylphenidate