Effects of axillary blockade on regional cerebral blood flow during dynamic hand contractions.
Regional cerebral blood flow (rCBF) was measured at orbitomeatal (OM) plane +5.0 and +9.0 cm in 10 subjects at rest and during dynamic hand contractions before and after axillary blockade. Handgrip strength was significantly reduced, and rating of perceived exertion increased after blockade. During hand contractions before blockade, contralateral hemispheric cerebral blood flow (CBF) at OM +9.0 increased from a resting value of 58 (49-75) to 63 (52-82) ml.100 g-1.min-1; contralateral motor sensory rCBF at OM +9 from 58 (50-77) to 71 (64-84); motor sensory rCBF at OM +5 from 67 (54-76) to 77 (64-87) and 70 (62-84) contralaterally and ipsilaterally, respectively; and supplementary motor area (SM) rCBF from 64 (53-69) to 75 (67-88) ml.100 g-1.min-1. During dynamic hand contractions after axillary blockade, CBF did not increase at OM +5 or in the SM. Furthermore, contralateral motor sensory rCBF at OM +9 increased much less. Axillary blockade had no effect on resting CBF, rCBF, or increases in the two during hand contractions of the opposite hand. Thus neural feedback from the contracting muscle is necessary for the increases in SM bilateral OM +5 motor sensory rCBF and the maximal increase in contralateral OM +9 motor sensory rCBF during dynamic hand contractions.
Friedman
D B
DB
Department of Clinical Physiology and Nuclear Medicine, Bispjeberg Hospital, Copenhagen, Denmark.
Friberg
L
L
Payne
G
G
Mitchell
J H
JH
Secher
N H
NH
D000328:Adult; D001365:Axilla; D001921:Brain / Q000033:anatomy & histology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005246:Feedback / Q000502:physiology; D005260:Female; D006225:Hand / Q000502:physiology*; D006801:Humans; D007537:Isometric Contraction / Q000502:physiology; D008012:Lidocaine; D008297:Male; D009046:Motor Neurons / Q000187:drug effects; D009119:Muscle Contraction / Q000502:physiology; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D009475:Neurons, Afferent / Q000187:drug effects; D015899:Tomography, Emission-Computed, Single-Photon; D014980:Xenon Radioisotopes
D009466:Neuromuscular Blocking Agents; D014980:Xenon Radioisotopes; D008012:Lidocaine