title: Cytotoxic activity of cardenolides from Beaumontia brevituba stems.
abstract: Five known cardenolides, digitoxigenin (1), oleandrigenin (2), digitoxigenin alpha-L-cymaroside (3), digitoxigenin beta-gentiobiosyl-alpha-L-cymaroside (4), and delta 16-digitoxigenin beta-D-glucosyl-alpha-L-cymaroside (5), were isolated from the stems of Beaumontia brevituba Oliver by cytotoxicity-directed fractionation monitored by a cultured human lung cancer cell line. The cytotoxic activity of these compounds was evaluated with a panel of twelve human and murine cancer cell lines. The lignan glycoside, syringaresinol beta-D-glucoside, was obtained for the first time in the form of its levo-enantiomer.
authors: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois, Chicago 60612.
authors: N
authors: N
authors: Kaneda
authors: H
authors: H
authors: Chai
authors: J M
authors: JM
authors: Pezzuto
authors: A D
authors: AD
authors: Kinghorn
authors: N R
authors: NR
authors: Farnsworth
authors: P
authors: P
authors: Tuchinda
authors: J
authors: J
authors: Udchachon
authors: T
authors: T
authors: Santisuk
authors: V
authors: V
authors: Reutrakul
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D002298:Cardenolides / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002298:Cardenolides