Cell injury and death caused by bacterial protein toxins.
Bacterial protein toxins, such as Clostridium difficile toxin A and the Escherichia coli cytotoxic necrotizing factor 1 are known to exert their cytotoxic action via a modification of some cytoskeletal components. The changes in actin organization caused by these toxins appear to be the primary events in the mechanism leading to cell death.
Donelli
G
G
Department of Ultrastructures, Istituto Superiore di Sanità, Rome, Italy.
Fiorentini
C
C
D000199:Actins / Q000502:physiology; D000818:Animals; D001427:Bacterial Toxins / Q000633:toxicity*; D016923:Cell Death / Q000187:drug effects*; D002460:Cell Line; D003603:Cytotoxins / Q000633:toxicity*; D004768:Enterotoxins / Q000633:toxicity*; D029968:Escherichia coli Proteins; D006801:Humans; D014407:Tumor Cells, Cultured
D000199:Actins; D001427:Bacterial Toxins; D003603:Cytotoxins; D004768:Enterotoxins; D029968:Escherichia coli Proteins; C041348:tcdA protein, Clostridium difficile; C060296:cytotoxic necrotizing factor type 1