[The effect of fluorine on the developing human brain].
Fifteen therapeutically aborted fetuses at the 5th-8th gestation month from the endemic fluorosis area were compared with those from the non-endemic area. Stereological study of the brains showed that the numerical density of volume of the neurons and the undifferentiated neuroblasts as well as the nucleus-cytoplasm ratio of the neurons were increased. The mean volume of the neurons was reduced. The numerical density of volume, the volume density and the surface density of the mitochondria were significantly reduced. The results showed that chronic fluorosis in the course of intrauterine fetal life may produce certain harmful effects on the developing brain of the fetus.
Du
L
L
Department of Pathology, Guiyang Medical College.
D001921:Brain / Q000187:drug effects* / Q000196:embryology / Q000648:ultrastructure; D005314:Embryonic and Fetal Development / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000187:drug effects*; D005461:Fluorine / Q000009:adverse effects*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008431:Maternal-Fetal Exchange; D008928:Mitochondria / Q000648:ultrastructure; D011247:Pregnancy
D005461:Fluorine