[Analysis of the reasons and mechanisms determining the occurrence of individual development in animals, beginning from the zygote (role of the cytoskeleton)].
Results of studies are presented revealing the role of motor activity (the energetic rule of skeletal muscles) as a factor determining the beginning of initiation of the organism individual development from the moment of zygote formation. The blockage of the cytoskeleton function (cytochalasin B, verapamil) was shown to result in the arrest of individual development and death of embryos. Mechanisms and causes of ambiguous action of these compounds are analysed. A biphasic pattern of the reaction of embryo cells is established. During the first short phase the function of microfilaments located near the membrane is blocked and further development of embryos is stopped. During the second, later and longer phase the function of cytoplasm microfilaments is blocked. The existing concepts as to the causes determining the individual development are discussed.
Arshavskiĭ
I A
IA
Mezhevikina
L M
LM
D000818:Animals; D003571:Cytochalasin B / Q000494:pharmacology; D003599:Cytoskeleton / Q000187:drug effects / Q000502:physiology*; D004622:Embryo, Mammalian / Q000648:ultrastructure; D004625:Embryo, Nonmammalian; D005314:Embryonic and Fetal Development; D008854:Microscopy, Electron; D009043:Motor Activity; D014700:Verapamil / Q000494:pharmacology
D003571:Cytochalasin B; D014700:Verapamil
K analizu prichin i mekhanizmov, opredeliaiushchikh vozniknovenie individual'nogo razvitiia u zhivotnykh, nachinaia s zigoty (rol' tsitoskeleta).