[Antineutrophil cytoplasmic antibodies--ANCA].
Antibodies against cytoplasm of neutrophil leucocytes (ANCA) with a high sensitivity are found in idiopathic necrotizing vasculitis and idiopathic glomerulonephritis with formation of sickles (IGS). C-ANCA are directed against the myeloid lysosomal enzyme--proteinase 3 and are found above all in Wegener's granulomatosis and microscopic polyarteritis. P-ANCA are directed mainly against myeloperoxidase, less against leucocytic elastase or lactoferrin and are found above all in microscopic polyarteritis, IGS, polyarteritis nodosa or Churg-Strauss syndrome. The elevated ANCA level correlates with the activity of the disease or precedes a relapse. These autoantibodies activate probably neutrophil leucocytes for respiratory exacerbation and degranulation which may lead to extensive tissue damage.
Vencovský
J
J
Revmatologický ústav, Praha.
Palecková
A
A
Becvár
R
R
D001323:Autoantibodies / Q000032:analysis; D003593:Cytoplasm / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000276:immunology; D014890:Granulomatosis with Polyangiitis / Q000276:immunology; D006801:Humans; D009504:Neutrophils / Q000276:immunology*; D014657:Vasculitis / Q000276:immunology
D001323:Autoantibodies
Protilátky proti cytoplazmĕ neutrofilních leukocytů--ANCA.