Morphology of rejection in experimental pancreas transplantation and its modification by cyclosporin A administration.
Histology of pancreas transplant rejection is complicated by non-specific appearances related to undrained exocrine secretions. Using a rat model of pancreas transplantation with exocrine drainage into the urinary tract, morphology of acute rejection has been studied with minimal interference from non-specific change. Unmodified acute rejection was complete after 7-9 days. Intralobular lymphocytic infiltration, which differentiated allografts from isografts, was present 5 days after transplantation and lymphocytic infiltration of islets and blood vessel walls developed between 5th and 7th days. Cyclosporin A immunosuppression of allografts resulted in marked attenuation of the cellular infiltrate. The nature of the infiltrate and its suppression with cyclosporin A indicated an allograft reaction.
Johnson
B F
BF
Northern General Hospital, Sheffield, UK.
Henry
L
L
Fox
M
M
Raftery
A T
AT
D000208:Acute Disease; D000818:Animals; D016572:Cyclosporine / Q000627:therapeutic use*; D006084:Graft Rejection / Q000473:pathology* / Q000517:prevention & control; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D010179:Pancreas / Q000473:pathology*; D016035:Pancreas Transplantation / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic
D016572:Cyclosporine