[Effect of antifolates and folates on the antineoplastic action of fluoropyrimidines].
The influence of folate and antifolate on the cytostatic activity of fluoropyrimidines has been examined extensively. From all of present work, it is apparent that methotrexate can be synergistic or antagonistic in its interaction with 5-fluorouracil, depending on the sequence used and the metabolic machinery present in the target cell. The interaction between commonly administered 5-fluorouracil and leucovorin may enhance carcinostatic efficacy of 5-fluorouracil in patients with colon carcinoma.
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Zakład Farmakologii Akademii Medycznej, Lodzi.
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000378:metabolism / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005472:Fluorouracil / Q000008:administration & dosage* / Q000037:antagonists & inhibitors / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D002955:Leucovorin / Q000008:administration & dosage* / Q000378:metabolism; D008727:Methotrexate / Q000008:administration & dosage* / Q000378:metabolism; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism
D002955:Leucovorin; D005472:Fluorouracil; D008727:Methotrexate
Wpływ antyfolianów i folianów na przeciwnowotworowe działanie fluoropirymidyn.