Dose-proportional plasma levels of the analgesic flupirtine maleate in man. Application of a new HPLC assay.
Single oral doses of the non-opioid, centrally-acting analgesic flupirtine maleate (Katadolon, CAS 75507-68-5) were administered to healthy volunteers and the 2 h plasma levels determined with a new specific HPLC assay. 50, 100, 200, and 300 mg were ingested as the commercial capsules in a double-blind randomized cross-over design with time intervals of at least 6 d. Dose-proportionality was observed for the median 2 h plasma levels which is in agreement with dose-proportionality previously described for multiple-dose studies.
Niebch
G
G
Asta Medica AG, Department of Biochemistry, Frankfurt, Main, Fed. Rep. of Germany.
Borbe
H O
HO
Hummel
T
T
Kobal
G
G
D000631:Aminopyridines / Q000097:blood*; D000700:Analgesics / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans
D000631:Aminopyridines; D000700:Analgesics; C034161:flupirtine