[Autoimmune polyendocrine syndrome. Treatment with intravenous immunoglobulins].
We report the effect of "intravenous gamma-globulin treatment" (IVIG) in a patient with autoimmune polyglandular syndrome type II, with circulating organ specific autoantibodies, preclinical hypothyroidism, amenorrhea and Addison syndrome. During IVIG treatment we observed a normalization of thyroid function, the appearance of some non ovulatory menses, reduction of thyroglobulin, thyroidal microsomal, anti-parietal cell, adrenal and ovary antibodies. These data confirm that intravenous immunoglobulin may represent a new tool for treatment of autoimmune disorders and show, for the first time, an immunosuppressive effect of intravenous gammaglobulin treatment in immunological phenomena direct against ovary, adrenal and gastric mucosa.
Antonelli
A
A
Istituto di Clinica Medica II, Università degli Studi di Pisa.
Gambuzza
C
C
Alberti
B
B
Saracino
A
A
Melosi
A
A
Agostini
S
S
Blunda
P
P
Baschieri
L
L
D000328:Adult; D001323:Autoantibodies / Q000097:blood; D005260:Female; D006728:Hormones / Q000097:blood; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D016884:Polyendocrinopathies, Autoimmune / Q000097:blood* / Q000276:immunology / Q000628:therapy*
D001323:Autoantibodies; D006728:Hormones; D016756:Immunoglobulins, Intravenous
Sindrome poliendocrina autoimmune. Trattamento con immunoglobuline endovena.