Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): cytomorphologic analysis on fine-needle aspirates.
Cytomorphologic characteristics of smears from fine-needle aspirates (FNA) of three cases of sinus histiocytosis with massive lymphadenopathy (SHML) (Rosai-Dorfman disease) are described. All aspirates showed mature lymphocytes, plasma cells, and large pale histiocytes with well-preserved lymphocytes within the cytoplasm (lymphocytophagocytosis). The cases were confirmed by surgical biopsy, and the immunohistochemical findings suggested a macrophage origin for this lesion. The value of FNA analysis as an aid to diagnosis of SHML is discussed.
Schmitt
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Department of Pathology, Botucatu School of Medicine, UNESP, Botucatu, São Paulo, Brazil.
D000293:Adolescent; D001707:Biopsy, Needle; D015618:Histiocytosis, Sinus / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male