Clinical characteristics of patients with epidermoid carcinoma of the upper aerodigestive tract who develop second malignant tumors.
A total of 1294 patients with primary head and neck (H&N) cancer of a single site was diagnosed during the years 1970 to 1979 at the Memorial Sloan-Kettering Cancer Center, 163 subsequently developed a second malignant tumor (SMT). In 50% of the cases, the second tumor was in the H&N, and in 30% in the lung and esophagus; 41 patients developed a third tumor. Again, in 50% of these cases, the tumor was in the H&N and in 17% in the lung and esophagus. The stage of disease of all the second primary tumors was more advanced at diagnosis, mainly as a result of the large number of patients with lung and esophagus cancer. Patients who had a second tumor in the H&N were diagnosed in an earlier stage of disease than patients with a single H&N tumor. The survival of patients with localized second H&N cancer was worse than for those with a primary, localized single tumor.
Robinson
E
E
Northern Israel Oncology Center, Rambam Medical Center, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
Zauber
A
A
Fuks
Z
Z
Strong
E
E
D000428:Alcohol Drinking; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology*; D004848:Epithelium / Q000473:pathology; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology*; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D016609:Neoplasms, Second Primary / Q000401:mortality / Q000473:pathology*; D012907:Smoking; D016019:Survival Analysis