In vitro activities of Ro 40-6890 against 164 predominantly intestinal members of the families Enterobacteriaceae and Vibrionaceae.
The in vitro activities of Ro 40-6890, the active metabolite of a novel orally absorbable cephalosporin ester, Ro 41-3399, against 164 nonfastidious aerobic gram-negative rods of predominantly intestinal origin from patients with diarrhea were evaluated by the agar dilution method recommended by the National Committee for Clinical Laboratory Standards. Ro 40-6890 was inhibitory (MIC for 90% of isolates [MIC90], 0.12 micrograms/ml) against the majority of intestinal members of the families Enterobacteriaceae and Vibrionaceae (Vibrio spp., Aeromonas spp., and Plesiomonas shigelloides). The potency of Ro 40-6890 was very similar to that of cefotaxime (MIC90, 0.12 micrograms/ml) and distinctly higher than those of cefadroxil (MIC90, > or = 128 micrograms/ml) and amoxicillin-clavulanic acid (MIC90, 32 micrograms/ml-2 micrograms/ml).
Hohl
P
P
Preclinical Research, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
Zollinger-Iten
J
J
von Graevenitz
A
A
D000658:Amoxicillin / Q000494:pharmacology; D002434:Cefadroxil / Q000494:pharmacology; D002439:Cefotaxime / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000494:pharmacology; D004755:Enterobacteriaceae / Q000187:drug effects*; D007422:Intestines / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D014737:Vibrionaceae / Q000187:drug effects*
D002511:Cephalosporins; D002969:Clavulanic Acids; D019818:Clavulanic Acid; D002434:Cefadroxil; C077918:Ro 406890; D000658:Amoxicillin; D002439:Cefotaxime