[Results of the clinical study of a new adrenergic beta blocker levobunolol hydrochloride in healthy subjects and in patients with glaucoma].
Effects of a single instillation of levobunolol, a new nonselective beta-adrenoblocker, in normal subjects and patients with various forms of glaucoma were under study, as were the effects of prolonged administration of this drug in patients with open-angle glaucoma. Short-term observations have revealed a hypotensive effect in all the examinees, the highest in patients with open-angle glaucoma (30.2%). Levobunolol did not influence the diameter of the pupil and accommodation, nor did it essentially change the cardiovascular activity. Prolonged administration of the drug resulted in a stable reduction of intraocular pressure by 20-30% in 70% of patients with open-angle glaucoma. Tonographic studies have shown that the drug reduced the intraocular fluid production and in case of a prolonged administration a trend to an elevation of the coefficient of the easiness of fluid discharge is observed.
Egorov
E A
EA
Shmeleva
I A
IA
D000293:Adolescent; D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D005260:Female; D005901:Glaucoma / Q000188:drug therapy* / Q000503:physiopathology; D015812:Glaucoma, Angle-Closure / Q000188:drug therapy / Q000503:physiopathology; D015355:Glaucoma, Neovascular / Q000188:drug therapy* / Q000503:physiopathology; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects* / Q000502:physiology; D002040:Levobunolol / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D013997:Time Factors
D002040:Levobunolol
Rezul'taty klinicheskogo izucheniia novogo beta-adrenoblokatora levobunolola gidrokhlorida u zdorovykh liudeĭ i bol'nykh glaukomoĭ.