title: Hemolytic anemia and thrombocytopenia induced by cyanidanol.
abstract: Five patients who received cyanidanol for 4-36 months are presented. Three developed both hemolytic anemia and thrombocytopenia, while 2 had only thrombocytopenia. After suspending the drug the hematological values returned to normal in all of the patients. Drug-dependent platelet antibodies were detected in 4 of the 5 patients and cyanidanol-dependent red blood cell antibodies were present in 3. There are various mechanisms involved in the cyanidanol-induced immune cytopenias and, as in the present study, were sometimes simultaneously observed in the same patient.
authors: Department of Experimental Medicine, La Sapienza, University of Rome, Italy.
authors: G M
authors: GM
authors: Gandolfo
authors: G
authors: G
authors: Girelli
authors: L
authors: L
authors: Conti
authors: M P
authors: MP
authors: Perrone
authors: M C
authors: MC
authors: Arista
authors: C
authors: C
authors: Damico
mesh_terms: D000368:Aged; D000743:Anemia, Hemolytic / Q000139:chemically induced / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000139:chemically induced*; D001792:Blood Platelets / Q000276:immunology; D002392:Catechin / Q000009:adverse effects*; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D013921:Thrombocytopenia / Q000139:chemically induced / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D002392:Catechin