Verapamil overdose: case report and review of the literature.
OBJECTIVE
To report the presentation and controversies regarding therapy of an 18-year-old man following a life-threatening ingestion of verapamil.


METHODS
An 18-year-old man ingested large quantities of dipyridamole, trimethoprim/sulfamethoxazole, amoxicillin, and verapamil. He presented to an outlying hospital and was initially conscious. Soon thereafter, the patient had a seizure; he required intubation, developed cardiac conduction abnormalities, and became hypotensive. The patient required pharmacologic pressors and a pacemaker for transfer to our institution. At our institution, vigorous fluid resuscitation, cardiac pacing, and careful attention to acid/base and electrolyte management provided the basis of therapy. The patient recovered without deficit and was discharged from the intensive care unit five days later.


CONCLUSIONS
Current controversies regarding the management of verapamil overdose are reviewed. Removal of the drug by gastric lavage is a mainstay of therapy. Administration of syrup of ipecac is contraindicated. Although specific recommendations for calcium dosing in the overdose situation have not been rigorously studied, maintenance of a normal serum ionized calcium concentration is suggested. An exogenous catecholamine, rather than dopamine, may be the drug of choice for treating hypotension. Cardiopulmonary bypass provides a method for drug removal in cases of severe toxicity; however, this invasive method requires further study. Management of fluid/electrolyte, acid/base, and ventilation abnormalities is required to treat large ingestions of verapamil. Treatment guidelines for critical care clinicians are provided.
Watling
S M
SM
Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, PA.
Crain
J L
JL
Edwards
T D
TD
Stiller
R A
RA
D000293:Adolescent; D002304:Cardiac Pacing, Artificial; D002606:Charcoal / Q000627:therapeutic use; D062787:Drug Overdose; D005440:Fluid Therapy; D005751:Gastric Lavage; D006327:Heart Block / Q000139:chemically induced; D006801:Humans; D008297:Male; D011041:Poisoning / Q000628:therapy; D012151:Resuscitation; D012640:Seizures / Q000139:chemically induced; D013406:Suicide, Attempted; D014700:Verapamil / Q000008:administration & dosage / Q000506:poisoning*
D002606:Charcoal; D014700:Verapamil