title: Zinc deficiency in the rat alters the lipid composition of the erythrocyte membrane Triton shell.
abstract: The effect of dietary zinc deficiency on the lipid composition of the erythrocyte membrane Triton shell was determined. Weanling male Wistar rats were fed an egg white-based diet containing < 1.0 mg Zn/kg diet ad libitum. Control rats were either pair-fed or ad libitum-fed the basal diet supplemented with 100 mg Zn/kg diet. A Zn refed group was fed the -Zn diet until day 18 and then pair-fed the +Zn diet until day 21. Dietary Zn deficiency caused an increased cholesterol/phospholipid ratio in Triton shells compared to those from pair-fed controls. Zn deficiency caused a decreased double bond index of fatty acids in phosphatidylinositol (PI) and phosphatidylcholine (PC); there was a decreased proportion of 18:2n-6 and 22:4n-6 in PC and 20:4n-6 in PI as compared to that found in pair-fed controls. All glycerophospholipids that were retained in the shell had a lower double bond index and increased content of 16:0 and/or 18:0 relative to the phospholipid in the intact membrane.
authors: Department of Nutritional Sciences, University of Guelph, Ontario, Canada.
authors: E R
authors: ER
authors: Driscoll
authors: W J
authors: WJ
authors: Bettger
mesh_terms: D000818:Animals; D004032:Diet; D004910:Erythrocyte Membrane / Q000737:chemistry / Q000187:drug effects*; D005231:Fatty Acids, Unsaturated / Q000032:analysis; D008297:Male; D008563:Membrane Lipids / Q000737:chemistry*; D017830:Octoxynol; D010713:Phosphatidylcholines / Q000737:chemistry; D010714:Phosphatidylethanolamines / Q000737:chemistry; D010716:Phosphatidylinositols / Q000737:chemistry; D010718:Phosphatidylserines / Q000737:chemistry; D011092:Polyethylene Glycols / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D013109:Sphingomyelins / Q000737:chemistry; D014886:Weaning; D015032:Zinc / Q000172:deficiency* / Q000494:pharmacology
chemical_list: D005231:Fatty Acids, Unsaturated; D008563:Membrane Lipids; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010716:Phosphatidylinositols; D010718:Phosphatidylserines; D013109:Sphingomyelins; D011092:Polyethylene Glycols; D017830:Octoxynol; D015032:Zinc