title: Expression of the junD proto-oncogene in the rat spinal cord and skin following noxious cutaneous ultraviolet irradiation.
abstract: Noxious peripheral stimulation induces the expression of various proto-oncogenes in rat spinal neurons. However, proto-oncogene expression seems to differ depending on the mode of the stimulus. Here, we report that noxious cutaneous ultraviolet (UV) irradiation results in a nearly 8-fold increase in junD mRNA levels in the rat lumbar spinal cord. RNA slot-blotting and hybridization techniques revealed a transcriptional activation of the junD proto-oncogene after 6 h, but not 1 h following UV exposure. These results suggest that low-frequency ongoing afferent impulse discharge is reflected by an accumulation in junD transcripts.
authors: II. Physiologisches Institut, Universität Heidelberg, FRG.
authors: F
authors: F
authors: Gillardon
authors: R J
authors: RJ
authors: Wiesner
authors: M
authors: M
authors: Zimmermann
mesh_terms: D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D004890:Erythema / Q000209:etiology / Q000503:physiopathology*; D005528:Foot; D005786:Gene Expression Regulation / Q000528:radiation effects; D008297:Male; D010146:Pain / Q000209:etiology / Q000503:physiopathology*; D016755:Proto-Oncogene Proteins c-jun / Q000096:biosynthesis*; D011519:Proto-Oncogenes; D012333:RNA, Messenger / Q000032:analysis; D011833:Radiation Injuries, Experimental / Q000209:etiology / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000378:metabolism* / Q000528:radiation effects; D013116:Spinal Cord / Q000378:metabolism* / Q000503:physiopathology; D013997:Time Factors; D014158:Transcription, Genetic; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D016755:Proto-Oncogene Proteins c-jun; D012333:RNA, Messenger