Cadmium-resistance plasmid in Staphylococcus lugdunensis.
Plasmids that confer resistance to cadmium (MIC > or = 125 microM), were found in 18 out of 30 independent Staphylococcus lugdunensis strains from clinical specimens. Variants that were cured of their plasmid were cadmium sensitive. Restriction endonuclease sites of a 3.2-kb cadmium-resistance plasmid of S. lugdunensis, designated pLUG10, were similar to those of pOX6, a S. aureus cadmium-resistance plasmid containing the cadB gene. Southern-blot hybridisation was performed with a probe intragenic to cadB. Hybridisation was found with the cadB probe in the cadmium-resistant S. lugdunensis isolates to the 2.9-, 3.2- and 3.7-kb plasmids. These findings suggest that cadmium-resistance in some S. lugdunensis strains is due to a gene sharing homology with the cadB gene of S. aureus.
Poitevin-Later
F
F
Hôpital Louis Pradel, Laboratoire de Bactériologie, Lyon, France.
Vandenesch
F
F
Dyke
K
K
Fleurette
J
J
Etienne
J
J
D002104:Cadmium / Q000494:pharmacology*; D004352:Drug Resistance, Microbial / Q000235:genetics; D011815:R Factors; D013210:Staphylococcus / Q000187:drug effects / Q000235:genetics*
D002104:Cadmium