Effect of dexfenfluramine on alcohol intake in alcohol-preferring "P" rats.
The intake of alcohol, in 2-h daily sessions, by the preferring (P) line of rats was reduced in a dose-related manner by acute subcutaneous (SC) administration of dexfenfluramine (DFEN). Ad lib intake of alcohol was reduced by chronic SC administration of DFEN. The effective doses and magnitude of effects of DFEN on alcohol intake are comparable to those previously reported for DFEN anorexia. Because DFEN anorexia is related to increased brain serotonin (5HT) activity, its effect on alcohol consumption may also be via 5HT.
Rowland
N E
NE
Department of Psychology, University of Florida, Gainesville 32611.
Morian
K R
KR
D000428:Alcohol Drinking / Q000235:genetics*; D000818:Animals; D005277:Fenfluramine / Q000494:pharmacology*; D008297:Male; D051381:Rats; D012701:Serotonin / Q000502:physiology
D005277:Fenfluramine; D012701:Serotonin