Localization of the human CYP17 gene (cytochrome P450(17 alpha)) to 10q24.3 by fluorescence in situ hybridization and simultaneous chromosome banding.
The gene for human P450(17 alpha) (CYP17) was previously mapped to chromosome 10 through analysis of somatic cell hybrids. Using a modified procedure of fluorescence in situ hybridization, this gene has now been visualized on simultaneously banded chromosomes and localized to a specific subband of chromosome 10 at q24.3. This precise assignment may facilitate the understanding of the molecular basis of 17 alpha-hydroxylase/17,20-lyase deficiency and the evolution of the CYP superfamily of genes.
Fan
Y S
YS
Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada.
Sasi
R
R
Lee
C
C
Winter
J S
JS
Waterman
M R
MR
Lin
C C
CC
D002871:Chromosome Banding; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D004247:DNA; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D013254:Steroid 17-alpha-Hydroxylase / Q000235:genetics*
D004247:DNA; D003577:Cytochrome P-450 Enzyme System; D013254:Steroid 17-alpha-Hydroxylase; C022433:pregnenolone 17-alpha-hydroxylase