[Study on the capillary permeability of myocardium in diabetic rats].
The alteration of myocardial capillary permeability (MCP) in experimental diabetic rat was investigated by using cationic ferritin as a tracer. Diabetes was induced by injection of streptozocin (70mg/kg b.w.ip.). Vehicle injected, age and body weight-matched rats were served as the controls. The myocardial tissue was examined by the end of 2,7, and 9 months or even longer after diabetes induction. Results showed that (1) MCP was significantly increased in diabetic rats in comparing with that of the controls; (2) The increase of permeability became more pronounced with prolongation of the course of diabetes; and (3) the increase of MCP preceded the capillary basal laminar thickening demonstrated by electron microscopy. These findings suggest that increased MCP may play a role in the pathogenesis of basal laminar thickening and myocardial complications in diabetic state.
Li
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Institute of Preclinical Sciences, Norman Bethune University of Medical Sciences, Changchun.
D000818:Animals; D001485:Basement Membrane / Q000378:metabolism / Q000473:pathology; D002199:Capillary Permeability; D003331:Coronary Vessels / Q000503:physiopathology*; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D005293:Ferritins / Q000493:pharmacokinetics; D008297:Male; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D005293:Ferritins