Indefinite survival of MHC class I-deficient murine pancreatic islet allografts.
To examine the immune response to class I-deficient allogeneic tissue, we used beta 2-microglobulin-deficient mice as graft donors. These mice lack cell surface class I major histocompatibility complex antigen expression. Pancreatic islet allografts from class I-deficient donors survived indefinitely in a majority of fully allogeneic BALB/c recipients. In contrast, host recognition of graft class I antigen was unnecessary for prompt destruction of skin allografts of for autoimmune damage of transplanted pancreatic islet grafts in nonobese diabetic mice. These studies provide evidence that intentional genetic elimination of immunologically relevant donor antigens may prove an effective strategy for preventing allograft rejection.
Markmann
J F
JF
Department of Surgery, Hospital of University of Pennsylvania, Philadelphia 19104.
Bassiri
H
H
Desai
N M
NM
Odorico
J S
JS
Kim
J I
JI
Koller
B H
BH
Smithies
O
O
Barker
C F
CF
D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery; D006085:Graft Survival; D015395:Histocompatibility Antigens Class I / Q000032:analysis* / Q000187:drug effects; D016381:Islets of Langerhans Transplantation / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D016688:Mice, Inbred NOD / Q000276:immunology; D016038:Skin Transplantation / Q000276:immunology; D013997:Time Factors; D014184:Transplantation, Homologous / Q000276:immunology; D001613:beta 2-Microglobulin / Q000172:deficiency / Q000494:pharmacology
D015395:Histocompatibility Antigens Class I; D001613:beta 2-Microglobulin