[A case of a carcinoma arising in lichen planus in a subject with diabetes mellitus and arterial hypertension (Grinspan's syndrome)].
The authors describe a clinical case observed at the Inst of Oral & Maxillofacial Surgery characterized by three simultaneous symptoms: arterious hypertension, diabetes mellitus, oral erosive lichen planus. Grinspan & his co-workers observed this syndrome. The results of their research were exposed at the Congress on Dermatology in Buenos Aires, 1963. In 1965 in a repetitive study Grupper & Avul seemed confirm the existence of this symptomatological triad; therefore the authors defined this complex as "Grinspan's syndrome". Further researches conducted by other authors (Jolly, Powell. Howell e Rick) confirmed the association hypertension-diabetes-"erosive" lichen. However there were other worthwhile studies (Lozada-Nur, Christensen) which emphasized a not significant high frequency of patients with diabetes and high blood pressure and the oral sugar tolerance like random specimens of common people. Besides the authors notice that their clinical case is interesting not only because of their simultaneous presence of the three symptoms but also because of the bioptic appearance of a cancer likely appeared on a pre-existing inveterate lichenoid lesion.
Colella
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Istituto di Chirurgia Orale e Maxillo Facciale, I Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli Federico II.
Itro
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A
Corvo
G
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D001706:Biopsy; D002277:Carcinoma / Q000209:etiology / Q000473:pathology*; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000473:pathology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000473:pathology*; D008010:Lichen Planus / Q000150:complications / Q000473:pathology*; D008875:Middle Aged; D009059:Mouth Diseases / Q000150:complications / Q000473:pathology*; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000209:etiology / Q000473:pathology*; D013577:Syndrome
Su di un caso di carcinoma insorto su lichen planus in soggetto con diabete mellito ed ipertensione arteriosa (sindrome di Grinspan).