In vitro nitroimidazole resistance of Trichomonas gallinae and successful therapy with an increased dosage of ronidazole in racing pigeons (Columba livia domestica).
Six out of eight different Trichomonas gallinae strains isolated from racing pigeons proved to be resistant to the nitroimidazole drugs ronidazole, carnidazole and metronidazole. The minimal cytocidal concentration of ronidazole was determined in in vitro experiments. Moreover, a therapeutic dose for ronidazole was determined for the control of trichomoniasis in pigeons from which the resistant T. gallinae strains were isolated. It was a 5-fold increase of the recommended ronidazole dosage which eliminated the infection in affected pigeons.
Franssen
F F
FF
Department of Tropical Veterinary Medicine and Protozoology, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands.
Lumeij
J T
JT
D000818:Animals; D000994:Antitrichomonal Agents / Q000494:pharmacology; D001715:Bird Diseases / Q000188:drug therapy* / Q000469:parasitology; D010856:Columbidae / Q000469:parasitology*; D004131:Dimetridazole / Q000494:pharmacology; D004351:Drug Resistance; D009593:Nitroimidazoles / Q000494:pharmacology*; D012385:Ronidazole / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D014244:Trichomonas / Q000187:drug effects* / Q000254:growth & development; D014245:Trichomonas Infections / Q000188:drug therapy / Q000662:veterinary*
D000994:Antitrichomonal Agents; D009593:Nitroimidazoles; D012385:Ronidazole; D004131:Dimetridazole; C014394:carnidazole