The influence of ascorbic acid on lipid peroxidation in guinea pigs intoxicated with cadmium.
Cadmium (as CdCl2) administered at a dose of 1 mg Cd/animal/day in drinking water to guinea pigs with a low intake of ascorbic acid (2 mg/animal/day) increased lipid peroxidation (LPO) in the kidney, liver and serum after 5 wk of treatment. A high intake of ascorbic acid (100 mg/animal/day) decreased LPO (determined from malondialdehyde levels) in the kidney, liver and serum of Cd-treated guinea pigs. Administration of Cd to guinea pigs with a low intake of ascorbic acid significantly increased LPO in the kidney at 5 wk, in comparison with controls given low levels of ascorbic acid but no Cd. However, at 12 wk, LPO in the kidney of Cd-treated guinea pigs was significantly lower than in the controls. These results indicate that the level of lipid peroxides in the kidney of guinea pigs with a low intake of ascorbic acid depends on the amount of accumulated cadmium.
Hudecová
A
A
Institute of Preventive and Clinical Medicine, Bratislava, Czechoslovakia.
Ginter
E
E
D000284:Administration, Oral; D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use*; D002104:Cadmium / Q000037:antagonists & inhibitors / Q000633:toxicity; D019256:Cadmium Chloride; D002105:Cadmium Poisoning / Q000378:metabolism / Q000517:prevention & control*; D002712:Chlorides / Q000037:antagonists & inhibitors / Q000633:toxicity; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism
D002712:Chlorides; D002104:Cadmium; D008315:Malondialdehyde; D019256:Cadmium Chloride; D001205:Ascorbic Acid