The murine NPY-1 receptor gene. Structure and delineation of tissue-specific expression.
The murine gene for the NPY-1 receptor subtype for neuropeptide Y was characterized by DNA sequencing and expression studies. It comprises three exons with a 6,400 bp 5'-untranslated and a 80 bp internal intronic sequence. The 5'-flanking region of this gene lacks TATA or CCAAT consensus sequences in the proximity to the multiple transcription initiation sites. A 1,300 bp genomic fragment of the 5'-flanking region drives the expression of the lacZ reporter gene in NG108-15 cells and primary cultured neurons but not in glial and human embryonic kidney cells. In addition, it contains consensus sequences for various transcription factors including cAMP- and glucocorticoid-responsive elements.
Eva
C
C
Istituto di Farmacologia e Terapia Sperimentale, University of Torino, Italy.
Oberto
A
A
Sprengel
R
R
Genazzani
E
E
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004247:DNA; D051379:Mice; D008969:Molecular Sequence Data; D009928:Organ Specificity / Q000235:genetics; D011401:Promoter Regions, Genetic; D017476:Receptors, Neuropeptide Y / Q000235:genetics*; D015183:Restriction Mapping
D017476:Receptors, Neuropeptide Y; D004247:DNA