Dactylocyclines, novel tetracycline derivatives produced by a Dactylosporangium sp. I. Taxonomy, production, isolation and biological activity.
A screen for antibiotics with activity against tetracycline-resistant microorganisms has led to the isolation of Dactylosporangium sp. (ATCC 53693), a producer of several novel tetracycline derivatives. The major fermentation products, dactylocyclines A and B, were purified and MIC values determined against tetracycline-resistant and tetracycline-sensitive Gram-positive bacteria. The dactylocyclines represent the first naturally occurring tetracycline C2 amides which lack cross resistance with tetracycline.
Wells
J S
JS
Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000.
O'Sullivan
J
J
Aklonis
C
C
Ax
H A
HA
Tymiak
A A
AA
Kirsch
D R
DR
Trejo
W H
WH
Principe
P
P
D000192:Actinomycetales / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002751:Chlortetracycline / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D013753:Tetracycline Resistance; D000095702:Polyether Toxins
D000900:Anti-Bacterial Agents; D002751:Chlortetracycline; C079467:dactylocycline A; D000095702:Polyether Toxins; C079466:dactylocycline B