Experimental animal model for the evaluation of chemotherapeutical effects on osteosarcoma.
In previous studies radiation-induced osteosarcoma transplanted onto nude rats has been shown to have an extraordinary similarity to human osteosarcoma. In this report the effects of a standard chemotherapeutic regimen on this experimental bone tumor are described. Examination of the histology and of the water content of the tumor confirmed that a high-dose cyclophosphamide monotherapy can cause severe necrosis in the tumor and its seeded lung metastases. A significant decrease in tumor volume of 50% (p < or = 0.01) was provoked and increased the mean survival rate of the treated rats (untreated rats: mean = 39.3 days) significantly to 53.6 days after transplantation of tumor fragments (p < or = 0.01).
Witzel
J G
JG
Department of Anatomy, Medical Faculty, Technical University of Aachen, FRG.
Prescher
A
A
Weisser
H
H
D000818:Animals; D001834:Body Water / Q000737:chemistry; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004195:Disease Models, Animal; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary; D009368:Neoplasm Transplantation; D012516:Osteosarcoma / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000556:secondary; D051381:Rats; D011923:Rats, Nude
D003520:Cyclophosphamide