Brown adipose tissue thermogenesis and metabolic rate contribute to the variation in obesity among rats fed a high fat diet.
A high fat (HF) diet is known to induce obesity, but susceptibility to obesity induced by a HF diet differs not only among different strains of rats but also within the same strain. The present study revealed that the Lee index (an index of obesity) positively correlated with insulin, and inversely correlated with both the mitochondrial oxygen consumption in interscapular brown adipose tissue (BAT) and the resting metabolic rate (RMR) in Sprague-Dawley rats. This suggests the contribution of BAT thermogenesis and RMR, in addition to hyperphagia, to the intrastrain variation in susceptibility to HF diet-induced obesity.
Yoshioka
K
K
First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan.
Yoshida
T
T
Kondo
M
M
D002001:Adipose Tissue, Brown / Q000502:physiology*; D000818:Animals; D001481:Basal Metabolism / Q000502:physiology*; D001833:Body Temperature Regulation / Q000502:physiology*; D004041:Dietary Fats / Q000494:pharmacology*; D005260:Female; D008928:Mitochondria / Q000502:physiology; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology*; D010101:Oxygen Consumption / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012146:Rest / Q000502:physiology
D004041:Dietary Fats