The organisation of the mouse secretogranin II gene.
We have characterized the gene which encodes mouse secretogranin II (previously also referred to as chromogranin C), a tyrosine-sulfated secretory protein belonging to the granin (chromogranin/secretogranin) family which is found in secretory granules of most endocrine cells and neurons. The secretogranin II gene was found to contain 2 exons. In contrast to chromogranin A and chromogranin B, the two previously characterized granin genes, the entire secretogranin II protein is encoded by a single exon, exon 2, with exon 1 containing only a 5'-untranslated sequence. Consistent with previous data on the expression of secretogranin II, the putative promoter region was found to contain a cAMP-responsive element and a potential AP-1 binding site.
Schimmel
A
A
Institute for Neurobiology, University of Heidelberg, Germany.
Bräunling
O
O
Rüther
U
U
Huttner
W B
WB
Gerdes
H H
HH
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D053379:Chromogranin A; D002864:Chromogranins / Q000235:genetics; D003001:Cloning, Molecular; D004247:DNA; D005091:Exons; D006801:Humans; D007438:Introns; D051379:Mice; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D011506:Proteins / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity
D053379:Chromogranin A; D002864:Chromogranins; D011506:Proteins; D004247:DNA