Polycythaemia after myeloid metaplasia with fibrosis: an unusual sequence.
In November 1981, a 77-yr-old woman consulted for myeloid metaplasia with fibrosis. A persistent hyperleucocytosis was treated with hydroxyurea from March, 1985 to March, 1989. At that time facial dyskinesia and polycythaemia developed. Investigations revealed a regression of myelofibrosis and a predominance of myeloid metaplasia in the liver. The mechanism of this event, rarely observed in myeloproliferative syndromes, is discussed in this new case.
Gardais
J
J
Laboratoire de cyto-hématologie, Centre Départemental de Transfusion Sanguine d'Angers, France.
Suraniti
S
S
Fressinaud
P
P
D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D005260:Female; D006411:Hematopoiesis, Extramedullary; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects / Q000627:therapeutic use; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D011087:Polycythemia Vera / Q000139:chemically induced / Q000150:complications* / Q000473:pathology; D055728:Primary Myelofibrosis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D011877:Radionuclide Imaging
D006918:Hydroxyurea