Phenolic constituents in Erythrina x bidwilli and their activity against oral microbial organisms.
Five flavonoid compounds, including two new isoflavanones, were isolated from the root bark of Erythrina x bidwilli. Their structures were determined to be 2,10-di(gamma,gamma-dimethylallyl)-3,9-dihydroxypterocarpan (erythrabyssin II), 6,8-di(gamma,gamma-dimethylallyl)-7,2',4'-trihydroxyisoflavanone (bidwillon A), 8-gamma,gamma-dimethylallyl-2',4'-dihydroxy-[6",6"-di-methylpyrano - (2",3":7,6)]isoflavanone (bidwillon B), 8-gamma,gamma-dimethylallyl-7,4'-dihydroxyisoflavone (8-gamma,gamma-dimethyl-allyldaidzein), and 8-gamma,gamma-dimethylallyl-5,2',4'-trihydroxy-[6",6"-dimethylpyrano+ ++- (2",3":7,6)]isoflavone (auriculatin), by means of spectroscopic analysis. Some potent activities against oral microbial organisms (Fusobacterium nucleatum and Prevotella intermedia) were shown in these flavonoid compounds.
Iinuma
M
M
Department of Pharmacognosy, Gifu Pharmaceutical University, Japan.
Tanaka
T
T
Mizuno
M
M
Yamamoto
H
H
Kobayashi
Y
Y
Yonemori
S
S
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004895:Erythrina / Q000737:chemistry*; D007529:Isoflavones / Q000302:isolation & purification* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009055:Mouth / Q000382:microbiology*; D010636:Phenols; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal
D000900:Anti-Bacterial Agents; D007529:Isoflavones; D010636:Phenols; D010936:Plant Extracts