[Comparison of effects of Elohes and albumin on hemostasis in orthopedic surgery].
A prospective study was carried out to determine the effects of Elohes, a low molecular weight hydroxyethylstarch, on haemostasis. Sixteen patients due to undergo total hip replacement were randomly assigned to one of two groups: group A, who were to receive up to 21 of 4% albumin to replace blood loss, and group E, 1.51 of Elohes. Patients were then given concentrated red cell packs (RCP) and lactated Ringer's solution so as to have a haematocrit value of 30%, up to the fifth postoperative day. The amount of blood lost intraoperatively was calculated by weighing the swabs and measuring the volume aspirated. Haemostasis was investigated on the eve of surgery, 3 hours afterwards, and then every second day (days 1, 3 and 5). Total blood loss and the number of RCP transfused were similar in both groups: 1,517 +/- 425 ml and 3.5 RCP, and 1,428 +/- 250 ml and 3.25 RCP in groups A and E respectively. Blood albumin concentrations fell in group E as expected, the starch diluting blood proteins. Bleeding time (Simplate), activated partial thromboplastin time, prothrombin time changed in the same way in both groups throughout the study period after infusion of either Elohes or albumin. The concentrations in factors II, V, VII and X fell by 30% three hours after surgery. Values returned to normal between days 1 and 3, the concentrations of some factors rising to values greater than preoperative values because of the postoperative inflammatory process (fibrinogen, factor VIII von Willebrand). However, there were no significant differences between the two groups.(ABSTRACT TRUNCATED AT 250 WORDS)
Rosencher
N
N
Département d'Anesthésie-Réanimation Chirurgicale, CHU, Paris.
Vassilieff
N
N
Guigonis
V
V
Toulon
P
P
Conseiller
C
C
D000418:Albumins / Q000494:pharmacology*; D001780:Blood Coagulation Tests; D016063:Blood Loss, Surgical; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D009985:Orthopedics; D011108:Polymers / Q000494:pharmacology*; D013213:Starch / Q000494:pharmacology*; D014841:von Willebrand Factor / Q000032:analysis
D000418:Albumins; D011108:Polymers; C062890:polystarch; D014841:von Willebrand Factor; D013213:Starch
Comparaison des effets de l'Elohes et de l'albumine sur l'hémostase en chirurgie orthopédique.