[The T1 time dependence of water measured in normal and neoplastic lung tissues].
The authors determined the time dependence of the average T1 relaxation time for the constitutive water of normal and neoplastic lung tissues. In healthy tissues, the T1 dependence appears strictly as a single decaying exponential function down to a threshold value which is invariant over time. The time change of T1 in neoplastic tissues is represented by monoexponential functions, in the short and long run, with a sudden drop 2 weeks after beginning measurements. Moreover, the time dependence is independent of the examined variant of epidermoid carcinoma. We report the kinetic constants of the in vitro aging of the tissues. The presence of a cooperative process, involving neoplastic lung water, to explain the features of aging changes, is also suggested.
Coletta
F
F
Centro di Studio sugli Stati Molecolari Radicali ed Eccitati del CNR, Università di Padova.
Tregnaghi
A
A
Lacognata
C
C
Calabrò
F
F
Muzzio
P C
PC
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D015633:Extravascular Lung Water / Q000502:physiology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008168:Lung / Q000033:anatomy & histology*; D008175:Lung Neoplasms / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D013997:Time Factors
Dipendenza temporale del T1 dell'acqua misurato su tessuti polmonari normali e neoplastici.