Conditioning regimens for allogeneic bone marrow transplantation.
Conditioning regimens for transplantation are important in determining transplant outcome. This review focuses on transplantation in aplastic anemia and leukemia using marrow from HLA-identical siblings. Results of conditioning with newer regimens such as busulfan plus cyclophosphamide and etoposide plus total body irradiation are reviewed and compared to results achieved with cyclophosphamide and total body irradiation. The potential for improved results using recent innovations such as dose adjustment of busulfan, agents which may decrease transplant-related toxicity, and directed radiation are discussed.
Copelan
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EA
Department of Internal Medicine, Ohio State University, Columbus.
D000741:Anemia, Aplastic / Q000601:surgery; D000961:Antilymphocyte Serum; D016465:Bone Marrow Purging / Q000009:adverse effects; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002066:Busulfan / Q000008:administration & dosage / Q000009:adverse effects; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007938:Leukemia / Q000601:surgery; D008212:Lymphocyte Depletion; D008558:Melphalan / Q000008:administration & dosage / Q000009:adverse effects; D013601:T-Lymphocytes; D014184:Transplantation, Homologous; D014916:Whole-Body Irradiation / Q000009:adverse effects
D000961:Antilymphocyte Serum; D003561:Cytarabine; D005047:Etoposide; D003520:Cyclophosphamide; D002066:Busulfan; D008558:Melphalan