Effects of inspiratory resistance, inhaled beta-agonists and histamine on canine tracheal blood flow.
Tracheobronchial blood flow is potentially important in asthma as it could either influence the clearance of mediators from the airways, thus affecting the duration and severity of bronchospasm, or enhance oedema formation with a resultant increase in airflow obstruction. In anaesthetized dogs, spontaneously breathing via a tracheostomy, we investigated the effects of three interventions which are relevant to acute asthma attacks and could potentially influence blood flow and its distribution to the mucosa and remaining tissues of the trachea: 1) increased negative intrathoracic pressure swings (-25 +/- 1 cmH2O) induced by an inspiratory resistance; 2) variable inhaled doses of a beta-adrenoceptor-agonist (terbutaline); and 3) aerosolized histamine sufficient to produce a threefold increase in pulmonary resistance. Microspheres labelled with different radioisotopes were used to measure blood flow. Resistive breathing did not influence tracheobronchial blood flow. Following a large dose of terbutaline, mucosal blood flow (Qmb) increased by 50%. After inhaled histamine, Qmb reached 265% of the baseline value. We conclude that, whereas increased negative pressure swings do not influence tracheobronchial blood flow or its distribution, inhalation of aerosolized terbutaline, corresponding to a conventionally nebulized dose, increases mucosal blood flow. Our results also confirm that inhaled histamine, in a dose sufficient to produce moderate bronchoconstriction, increases tracheal mucosal blood flow in the area of deposition.
Kelly
W T
WT
Dept of Respiratory Medicine, Westmead Hospital, NSW, Australia.
Baile
E M
EM
Brancatisano
A
A
Paré
P D
PD
Engel
L A
LA
D000280:Administration, Inhalation; D000403:Airway Resistance / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D012119:Respiration / Q000187:drug effects / Q000502:physiology; D013726:Terbutaline / Q000008:administration & dosage / Q000494:pharmacology*; D014132:Trachea / Q000098:blood supply* / Q000187:drug effects
D006632:Histamine; D013726:Terbutaline