Synthetic approaches to vaccines for infectious and autoimmune diseases.
The development is outlined of some synthetic vaccines against infectious diseases, in particular cholera, shigella and influenza. In the last case, use of the synthetic adjuvant MDP in combination with a haemagglutinin peptide has led to a synthetic vaccine with built-in adjuvanticity. The production of vaccines both by chemical synthesis and genetic engineering is described. The successful use of the synthetic amino acid copolymer COP-1 as an immunomodulatory vaccine to suppress the onset of allergic encephalomyelitis in experimental animals has led to clinical trials with patients suffering from exacerbating remitting multiple sclerosis. T-cell vaccination is an alternative approach to immunization against autoimmune diseases.
Sela
M
M
Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.
Arnon
R
R
D000276:Adjuvants, Immunologic; D000818:Animals; D000941:Antigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology / Q000517:prevention & control* / Q000628:therapy; D001427:Bacterial Toxins / Q000276:immunology; D003140:Communicable Disease Control; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000517:prevention & control; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral / Q000276:immunology; D006801:Humans; D016219:Immunotherapy, Adoptive; D051379:Mice; D016688:Mice, Inbred NOD; D009103:Multiple Sclerosis / Q000276:immunology / Q000517:prevention & control / Q000628:therapy; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000276:immunology; D010455:Peptides / Q000276:immunology / Q000627:therapeutic use; D051381:Rats; D011922:Rats, Mutant Strains; D013601:T-Lymphocytes / Q000276:immunology / Q000637:transplantation; D014611:Vaccination; D014614:Vaccines, Synthetic
D000276:Adjuvants, Immunologic; D000941:Antigens; D001427:Bacterial Toxins; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral; D010446:Peptide Fragments; D010455:Peptides; D014614:Vaccines, Synthetic; C021759:(T,G)-A-L