Time-dependent anesthetic and anticonvulsant activities of alphaxalone in Syrian hamsters.
To assess whether the anesthetic and anticonvulsant activities of alphaxalone display diurnal variability, groups of Syrian hamsters were studied at 4 h-intervals during a 24 h-cycle. The administration of alphaxalone (5 mg/kg) brought about a greater anesthetic activity (loss of righting reflex) at the middle of the photophase. When assessed in hamsters injected with 3-mercaptopropionic acid, alphaxalone displayed maximal anticonvulsant activity at the 4th of darkness. Evaluation of the time needed for first convulsive response indicated that alphaxalone did not show time-dependent effects, while in control hamsters seizure threshold was low during daylight and attained maximal values at night, showing a peak in seizure threshold at light-dark transition.
Guinjoan
S M
SM
Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
Golombek
D A
DA
Cardinali
D P
DP
D015097:3-Mercaptopropionic Acid / Q000494:pharmacology; D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects; D002940:Circadian Rhythm / Q000187:drug effects*; D006224:Cricetinae; D007274:Injections, Intraperitoneal; D008297:Male; D008647:Mesocricetus; D009043:Motor Activity / Q000187:drug effects; D011277:Pregnanediones / Q000494:pharmacology*; D012021:Reflex, Abnormal / Q000187:drug effects; D012640:Seizures / Q000188:drug therapy
D000777:Anesthetics; D000927:Anticonvulsants; D011277:Pregnanediones; D015097:3-Mercaptopropionic Acid; C006477:alphaxalone