A case of cytophagic histiocytic panniculitis with sicca symptoms and lupus nephritis.
A 48-year-old Japanese woman presented with many subcutaneous nodules. The skin was purplish in color and tender; the nodules were scattered over the entire surface. Histological findings of biopsy specimens from the nodules indicated septal panniculitis comprised of histiocyte and/or macrophage infiltrates, often with erythro- and/or leukophagocytosis. Phagocytic cells were OKM1 (CD11b), MT1 (CD43), LeuM3 (CD14), and histiocyte antigen positive, indicating the presence of histiocytes and/or macrophages. The patient had sicca symptoms, positive homogenous, speckled pattern ANA (x320), and diffuse proliferative lupus nephritis.
Tsukahara
T
T
Department of Dermatology, Kitasato University School of Medicine, Sagamihara, Japan.
Fujioka
A
A
Horiuchi
Y
Y
Eto
H
H
Nishiyama
S
S
Akaboshi
T
T
Kokubo
T
T
D005260:Female; D006644:Histiocytes / Q000648:ultrastructure*; D006801:Humans; D008181:Lupus Nephritis; D008875:Middle Aged; D015434:Panniculitis / Q000473:pathology*; D010586:Phagocytes / Q000648:ultrastructure; D012859:Sjogren's Syndrome