Epithelial membrane antigen and S-100 protein-labeled cells in primary and metastatic laryngeal carcinomas.
Immunohistochemical studies were done on the expression of S-100 protein-labeled cells in human laryngeal carcinoma of epithelial membrane antigen (EMA) and on the population density. EMA was detected in 65 of 76 (86%) squamous cell carcinomas and was usually more extensively positive in well and moderately differentiated carcinomas. Thus, EMA can serve as a marker of malignancy in laryngeal carcinomas. The population density of S-100 protein-labeled cells was high in well-differentiated tissues. In the metastatic tumors, the number of S-100 protein-labeled cells decreased as compared to findings in the primary tumors. As a statistically significant difference in survival curve was noted between groups with low and intermediate density of S-100 protein-labeled cells, the infiltration of S-100 protein-labeled cells seems to be associated with a better prognosis.
Nakashima
T
T
Department of Otolaryngology, National Kyushu Cancer Center, Fukuoka, Japan.
Yano
G
G
Hayashi
I
I
Katsuta
Y
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000556:secondary; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis*; D008875:Middle Aged; D018396:Mucin-1; D009367:Neoplasm Staging; D011379:Prognosis; D009418:S100 Proteins / Q000032:analysis*; D015996:Survival Rate
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D008562:Membrane Glycoproteins; D018396:Mucin-1; D009418:S100 Proteins