title: Determination of chloramphenicol in muscle using a particle beam interface for combining liquid chromatography with negative-ion chemical ionization mass spectrometry.
abstract: A simple and rapid liquid chromatographic-mass spectrometric analysis of chloramphenicol in calf muscle is presented. A particle beam interface was used, with negative-ion chemical ionization mass spectrometry using methane as the reagent gas. The method specificity was tested for three related compounds, dehydrochloramphenicol, nitrosochloramphenicol and nitrophenylaminopropanediol. The extraction procedures require 5 g of muscle, and the quantification limit is 2 micrograms/kg for chloramphenicol. Residues were detected in calf muscle 48 h after intravenous administration of chloramphenicol (25 mg/kg body weight).
authors: Centre National d'Etudes Vétérinaires et Alimentaires, Laboratoire des Médicaments Vétérinaires, Fougeres, France.
authors: B
authors: B
authors: Delépine
authors: P
authors: P
authors: Sanders
mesh_terms: D000818:Animals; D002417:Cattle; D002701:Chloramphenicol / Q000008:administration & dosage / Q000032:analysis*; D002853:Chromatography, Liquid / Q000379:methods*; D007275:Injections, Intravenous; D013058:Mass Spectrometry / Q000379:methods*; D009132:Muscles / Q000737:chemistry*
chemical_list: D002701:Chloramphenicol