Thiazolo[3,2-a]pyrimidine derivatives as calcium antagonists.
Some new thiazolo[3,2-a]pyrimidine derivatives were prepared refluxing 2-thioxo-1,2,3,4-tetrahydropyrimidine derivatives with phenacyl bromide in glacial acetic acid. Calcium antagonistic activities of these compounds were evaluated in K(+)-depolarized rat aorta, using nifedipine as reference compound.
Balkan
A
A
Department of Pharmaceutical Chemistry, Hacettepe University, Faculty of Pharmacy.
Uma
S
S
Ertan
M
M
Wiegrebe
W
W
D000818:Animals; D002121:Calcium Channel Blockers / Q000138:chemical synthesis* / Q000494:pharmacology; D066298:In Vitro Techniques; D017275:Isradipine / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D011743:Pyrimidines / Q000138:chemical synthesis*; D051381:Rats; D013844:Thiazoles / Q000138:chemical synthesis*
D002121:Calcium Channel Blockers; D011743:Pyrimidines; D013844:Thiazoles; D017275:Isradipine