Diuretic activity of organomercury (II) complexes of theophylline and theobromine.
Organomercury(II) complexes of the types, p-XC6H4HgL (A) and p-XC6H4HgCl(L') (B) [LH = theophylline; L' = theobromine; X = Me, NO2], have been synthesised and characterized. Conductance measurements indicate that the complexes are non-electrolytes. The structures of the complexes have been elucidated by spectral studies (IR, UV, and 1H, 13C NMR). The complexes have been tested for diuretic activity. The structure-activity relationship has been propounded.
Kaur
J
J
Department of Chemistry, University of Delhi, India.
Sodhi
G S
GS
D000818:Animals; D004231:Diuresis / Q000187:drug effects*; D004232:Diuretics / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015394:Molecular Structure; D009941:Organomercury Compounds / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D013805:Theobromine / Q000737:chemistry / Q000494:pharmacology*; D013806:Theophylline / Q000737:chemistry / Q000494:pharmacology*
D004232:Diuretics; D009941:Organomercury Compounds; D013806:Theophylline; D013805:Theobromine