The immunopathogenic role of food hypersensitivity in atopic dermatitis.
Food hypersensitivity is reported to play an immunopathogenic role in atopic dermatitis in approximately one-third of children. In 320 selected children with moderate to severe atopic dermatitis, 63% of children were found to have food hypersensitivity by double-blind placebo-controlled food challenges. Both IgE-mediated mast cell and mononuclear cell activation appear responsible for the eczematous lesions resulting from ingestion of food allergens.
Sampson
H A
HA
Division of Allergy/Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
D000328:Adult; D002648:Child; D002908:Chronic Disease; D003876:Dermatitis, Atopic / Q000276:immunology*; D004311:Double-Blind Method; D005512:Food Hypersensitivity / Q000150:complications* / Q000276:immunology; D006801:Humans