title: Effect of prostaglandin synthesis inhibition on glomerular filtration rate in renal transplant recipients.
abstract: To determine the influence of prostaglandin (PG) synthesis inhibition on the renal function in renal transplant recipients, we carried out a crossover, double-blind, placebo controlled study of 18 ambulatory patients. Glomerular filtration rate (GFR) was measured using 51-Cr EDTA, before and after indomethacin (50 mgr. three times a day for three days), and placebo. Overnight urinary PGE excretion decreased 88.9 +/- SEM 4.81% after indomethacin, but remained unchanged following placebo. GFR decreased 15.3 +/- SEM 3.94% (p = 0.0139) after indomethacin. There was no correlation between PGE urinary excretion and GFR changes. Pre-existing renal functional impairment was not a significant risk factor. Caution should be exercised when using non-steroidal anti-inflammatory drugs in renal transplant patients.
authors: Renal Service and Laboratory, Hospital Universitario, Maracaibo, Venezuela.
authors: C
authors: C
authors: Marín
authors: J
authors: J
authors: Herrera
authors: J
authors: J
authors: Manzanares
authors: B
authors: B
authors: Rodríguez-Iturbe
mesh_terms: D000293:Adolescent; D000328:Adult; D002860:Chromium Radioisotopes; D004311:Double-Blind Method; D004492:Edetic Acid; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011453:Prostaglandins / Q000502:physiology*; D011458:Prostaglandins E / Q000652:urine
chemical_list: D002860:Chromium Radioisotopes; D011453:Prostaglandins; D011458:Prostaglandins E; D004492:Edetic Acid; D007213:Indomethacin