title: Changes of acetylcholinesterase activity in hepatectomized rats following soman poisoning.
abstract: Acetylcholinesterase activity in the blood, pontomedullar area, basal ganglia of the brain and diaphragm following sublethal soman poisoning (i. m., 31 micrograms/kg) was studied in four groups of rats (n = 6) pretreated as follows: intact, hepatectomized (65 % of resection), sham-operated and narcotized animals. Soman was administered 12 hours following hepatectomy, narcosis or sham-operation, respectively. Except hepatectomized rats, all animals in the groups survived: in hepatectomized rats, 2 animals died. Acetylcholinesterase activity was decreased in each group. The differences among enzyme activities in these groups were not statistically significant for the blood. The highest and significant (p < 0.01) decrease of this activity in the brain parts and diaphragm following hepatectomy was demonstrated. The results indicate that undiminished liver functional capacity is an important factor influencing soman toxicity.
authors: Radioisotope Laboratory, Medical Faculty, Charles University, Hradec Králové.
authors: F
authors: F
authors: Skopec
authors: J
authors: J
authors: Bajgar
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D006498:Hepatectomy; D008297:Male; D011041:Poisoning / Q000201:enzymology; D051381:Rats; D017208:Rats, Wistar; D012999:Soman / Q000506:poisoning*
chemical_list: D012999:Soman; D000110:Acetylcholinesterase