Barrett's oesophagus.
Barrett's oesophagus or columnar lined epithelium of the oesophagus (CLO) is a metaplastic condition associated with excessive gastro-oesophageal reflux. It is found in 15% of patients with reflux oesophagitis. In a detailed study of 115 CLO patients dysplasia was found in 46%; 13.9% were moderate or severe dysplasia, usually found in intestinal type CLO. Fifty patients were endoscoped annually to determine the natural history of the disease. The incidence of adenocarcinoma was 1 in 52 patient-years, a 125-fold excess risk. A dysplasia-carcinoma sequence was seen in the five who developed carcinoma. Patients with early carcinoma were treated surgically with 12% postoperative mortality and 100% survival for 24-70 months.
Bartlesman
J F
JF
Department of Gastroenterology, Academic Medical Centre, Amsterdam, The Netherlands.
Hameeteman
W
W
Tÿtgat
G N
GN
D000046:Academic Medical Centers; D000230:Adenocarcinoma / Q000453:epidemiology* / Q000209:etiology / Q000601:surgery; D001471:Barrett Esophagus / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D001706:Biopsy; D003663:Decision Trees; D004938:Esophageal Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000601:surgery; D004945:Esophagoscopy; D005500:Follow-Up Studies; D005764:Gastroesophageal Reflux / Q000150:complications; D006801:Humans; D015994:Incidence; D009367:Neoplasm Staging; D009426:Netherlands / Q000453:epidemiology; D011379:Prognosis; D015996:Survival Rate; D014463:Ultrasonography