[The functional characteristics of the inhibitory mediator systems in the brain synaptosomes of PP vitamin-deficient rats].
A decrease of the NAD and serotonin level in the brain of rats with PP hypovitaminosis is shown. NAD in concentration of 10(-6) M in vitro exerts a less pronounced inhibiting influence on the neuronal uptake of [14C]serotonin and [14C]GABA by brain synaptosomes of rats with PP hypovitaminosis. GABA content under such conditions increases as compared with the control and correlates with changes in the [14C]GABA uptake system.
Fomenko
A I
AI
Chichkovskaia
G V
GV
Parkhomets
P K
PK
Donchenko
G V
GV
Stepanenko
S P
SP
Khalmuradov
A A
AA
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects; D002250:Carbon Radioisotopes; D008297:Male; D009243:NAD / Q000378:metabolism / Q000494:pharmacology; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology*; D009536:Niacinamide / Q000172:deficiency*; D010383:Pellagra / Q000378:metabolism*; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D002250:Carbon Radioisotopes; D009243:NAD; D009536:Niacinamide; D012701:Serotonin; D005680:gamma-Aminobutyric Acid
Osobennosti funktsionirovaniia tormoznykh mediatornykh sistem sinaptosom golovnogo mozga u PP-gipovitaminoznykh krys.