Thrombolysis with low dose tissue plasminogen activator.
Two cases of vena caval thrombosis in infants were successfully treated with low dose (0.01-0.05 mg/kg/hour) local infusions of tissue plasminogen activator after conventional anticoagulant treatment had been unsuccessful. This approach is useful for clots associated with indwelling intravascular catheters, and a low dose infusion of tissue plasminogen activator as a regional application is recommended to achieve clot lysis with minimal systemic effects.
Doyle
E
E
Intensive Care Unit, Royal Hospital for Sick Children, Yorkhill, Glasgow.
Britto
J
J
Freeman
J
J
Munro
F
F
Morton
N S
NS
D002408:Catheters, Indwelling / Q000009:adverse effects; D004334:Drug Administration Schedule; D006801:Humans; D007223:Infant; D008297:Male; D015912:Thrombolytic Therapy / Q000379:methods*; D013927:Thrombosis / Q000209:etiology*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*; D014683:Vena Cava, Superior
D010959:Tissue Plasminogen Activator