Lethal and non-lethal course of endotoxic shock is determined by interactions between tumor necrosis factor, platelet activating factor and eicosanoids.
Continuous lipopolysaccharide (LPS) infusion in pigs induced death in approximately half of the animals and a prolonged state of shock (up to 3 hours of experimental observation period, i.e., two hours after discontinuation of LPS infusion) in the surviving animals. Lethal-induced shock was marked by huge release of Tumor Necrosis Factor (TNF) into the blood, whereas eicosanoid and Platelet Activating Factor (PAF) levels remained unchanged. In pigs surviving LPS-infusion but still remaining in a state of shock, transient increases in PAF and thromboxane levels were observed, whereas prostacyclin and leukotrienes values remained above normal levels up to the end of the observation period. It is concluded that different types of mediators play a role in LPS-induced lethal shock as compared to non-lethal prolonged state of shock.
Mozes
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Institute of Pharmacology, Faculty of Medicine, Erasmus University Rotterdam, The Netherlands.
Ben-Efraim
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Bonta
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D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004224:Diterpenes; D015777:Eicosanoids / Q000097:blood*; D004731:Endotoxins / Q000009:adverse effects / Q000494:pharmacology*; D004926:Escherichia coli; D046934:Ginkgolides; D007213:Indomethacin / Q000494:pharmacology; D007783:Lactones / Q000494:pharmacology; D010972:Platelet Activating Factor / Q000032:analysis* / Q000037:antagonists & inhibitors; D012772:Shock, Septic / Q000139:chemically induced*; D013552:Swine; D013929:Thromboxane B2 / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
D004224:Diterpenes; D015777:Eicosanoids; D004731:Endotoxins; D046934:Ginkgolides; D007783:Lactones; D010972:Platelet Activating Factor; D014409:Tumor Necrosis Factor-alpha; D013929:Thromboxane B2; C045856:ginkgolide B; D007213:Indomethacin