Pediatric HIV-1 infection: a clinical overview.
Several questions remain unanswered including the timing of perinatal transmission, maternal factors predisposing to perinatal transmission of HIV-1, the best methods for early diagnosis in the neonate, and means of preventing perinatal HIV-1 infection. Significant advances have been made in the early diagnosis of HIV-1 infection, and now it is possible to make a diagnosis in most infants by 6 months of age. Unfortunately, not all these techniques are commercially available, so this capability is limited to certain institutions and laboratories. The natural history of HIV-1 infection in children continues to evolve, particularly with increased prophylaxis of P. carinii pneumonia and the availability of antiretroviral therapy. Our challenges for the future are to prevent perinatal transmission, to develop new and better therapies for opportunistic infections and HIV-associated complications, and to improve outcome and prognosis.
Scott
G B
GB
Division of Pediatric Infectious Disease and Immunology, University of Miami School of Medicine, Florida.
D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D015497:HIV-1; D006801:Humans; D007223:Infant; D008431:Maternal-Fetal Exchange; D011020:Pneumonia, Pneumocystis / Q000209:etiology / Q000401:mortality / Q000517:prevention & control; D011247:Pregnancy; D011379:Prognosis; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D014481:United States / Q000453:epidemiology
D015662:Trimethoprim, Sulfamethoxazole Drug Combination