The biology and genetics of hereditary cancers.
Hereditary cancer syndromes are generally produced by the inheritance of a single mutant gene. New tools have been developed that enable research workers to locate the defective genes responsible for the inherited forms of cancer. Once a disease gene has been localized, it may be possible to identify individuals who have inherited the disease gene before cancer develops.
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Laboratory of Immunobiology, National Cancer Institute-Frederick Cancer Research Facility, MD 21702.
D015870:Gene Expression; D016147:Genes, Tumor Suppressor; D005819:Genetic Markers; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics*; D010375:Pedigree; D011110:Polymorphism, Genetic
D005819:Genetic Markers