title: Synthesis and some central pharmacological properties of new 5(1H)oxo-2,3-dihydroimidazo[1,2-a]pyrimidine-6-carboxylic esters.
abstract: Six new 5(1H)oxo-2,3-dihydroimidazo[1,2-a]pyrimidine-6-carboxylic ethyl esters bearing an aromatic substituent in position 1 or 2 were obtained. Pharmacological studies on the central action of these derivatives were carried out on mice and rats. The highest activity showed compounds 1 and 2 which produced analgesic effects in mice.
authors: Department of Chemical Technology of Drugs, Medical Academy, Lublin, Poland.
authors: D
authors: D
authors: Matosiuk
authors: T
authors: T
authors: Tkaczyński
authors: E
authors: E
authors: Jagiełło-Wójtowicz
authors: M
authors: M
authors: Wielosz
authors: G
authors: G
authors: Szurska
authors: A
authors: A
authors: Chodkowska
authors: W
authors: W
authors: Janusz
authors: Z
authors: Z
authors: Kleinrok
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D011743:Pyrimidines