V-ATPases in phagocytic cells.
V-ATPases in phagocytic cells are known to mediate the acidification of most intracellular organelles. Proton-pump-mediated acidification of these organellar compartments is vital to numerous cell processes, including receptor recycling, protein processing and sorting and microbial degradation. Recent studies have suggested a role for V-ATPases in cytoplasmic pH homeostasis. The present discussion will review the current knowledge regarding the presence of V-ATPases in both the plasmalemmal and organellar membranes of phagocytic cells, the regulation of proton pump activity in these locations and the functional significance of pump-mediated proton translocation.
Grinstein
S
S
Division of Cell Biology Hospital for Sick Children, Toronto, Canada.
Nanda
A
A
Lukacs
G
G
Rotstein
O
O
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D003593:Cytoplasm / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008264:Macrophages / Q000378:metabolism; D009504:Neutrophils / Q000378:metabolism; D015388:Organelles / Q000378:metabolism; D010586:Phagocytes / Q000201:enzymology*; D025262:Vacuolar Proton-Translocating ATPases
D000251:Adenosine Triphosphatases; D025262:Vacuolar Proton-Translocating ATPases