Enhanced monoamine release in the median preoptic area following reduced extracellular fluid volume in rats.
The role of monoaminergic neural inputs to fluid regulatory systems in the median preoptic nucleus (MnPO) was investigated by examination of monoamine metabolism during reduction of systemic extracellular fluid volume in freely moving rats. Extracellular fluid volume was decreased iso-osmotically by subcutaneous polyethylene glycol (PEG), and extracellular noradrenaline (NA), dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA) were measured using intracerebral microdialysis techniques. PEG treatments significantly increased NA, DA and DOPAC release in the MnPO area. The results suggest that monoaminergic neural systems in the region of the MnPO are important in the control of extracellular fluid balance.
Tanaka
J
J
Department of Physiology, Saitama Medical School, Japan.
Hori
K
K
Koito
H
H
Nomura
M
M
D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D003956:Dialysis; D005110:Extracellular Space / Q000378:metabolism*; D008297:Male; D011092:Polyethylene Glycols / Q000494:pharmacology; D011301:Preoptic Area / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D015306:Biogenic Monoamines; D011092:Polyethylene Glycols