The 5' region of the human thyroglobulin gene contains members of the Alu family.
Repeated sequences were identified in the 5' region of the human Tg gene in introns 4, 5, 10, and 11. Another repeated cluster was located in the 5' flanking sequences, approximately 6 Kb upstream from the first exon. The nucleotide sequence analysis indicated that these repeated sequences are members of the Alu family. The homology between the sequences of the intron 4 and the Alu consensus was 86%. The Alu member studied was oriented in the direction of transcription of the Tg.
Targovnik
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H
Laboratorio de Biologia Molecular, Hospital de Clinicas José de San Martin, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina.
Paz
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C
Corach
D
D
Christophe
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D
D001483:Base Sequence; D015139:Blotting, Southern; D004247:DNA / Q000737:chemistry; D015246:Deoxyribonuclease EcoRI; D005091:Exons; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D012091:Repetitive Sequences, Nucleic Acid; D015183:Restriction Mapping; D013954:Thyroglobulin / Q000235:genetics*
D004247:DNA; D013954:Thyroglobulin; D015246:Deoxyribonuclease EcoRI