[The effect of quinidine monotherapy and combined therapy with digoxin on the central hemodynamics in patients with heart rhythm disorders].
The study was undertaken to examine 84 patients mainly with coronary heart disease and various cardiac arrhythmias. Quinidine monotherapy was found to normalize heart rate depending on its baseline values: it reduced heart rate in tachycardias and increased it in bradycardia. In patients with severe myocardial damage, especially in hypertension, quinidine decreased cardiac index, whereas total peripheral resistance increased. With quinidine, systolic pressure, stroke and cardiac indices showed a more decrease, whereas diastolic pressure and total peripheral resistance displayed a more increase in the standing position. Supplement of digoxin corrected negative quinidine-induced hemodynamic changes and orthostatic failures.
Orlov
L L
LL
Glezer
M G
MG
Tsintsadze
G I
GI
Zaĭchik
I L
IL
D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000503:physiopathology; D004077:Digoxin / Q000627:therapeutic use*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011802:Quinidine / Q000627:therapeutic use*; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; C009764:quinidine bisulfate; D004077:Digoxin; D011802:Quinidine
Vliianie monoterapii khinidinom i sochetannoĭ terapii s digoksinom na tsentral'nuiu gemodinamiku u bol'nykh s narusheniiami ritma serdtsa.