title: Tc-99m DTPA diffuse pulmonary uptake in patients with coronary artery disease and renal insufficiency.
abstract: Diffuse bilateral lung uptake was observed in 10 patients undergoing Tc-99m DTPA renal scanning, referred for the evaluation of rising serum creatinine levels. All 10 patients demonstrated renal insufficiency (RI) as shown by both decreased bilateral renal tracer concentration and elevated background activity. Nine of the patients were known to have coronary artery disease (CAD) and six of these nine patients were in congestive heart failure (CHF), at or around the time of scanning. However, Tc-99m DTPA lung uptake was not observed in five other patients whose scans demonstrated RI, in whom there was no CAD or other cardiac disease. Diffuse lung uptake of Tc-99m DTPA in patients with RI therefore is highly suggestive of cardiac dysfunction (i.e. CAD and/or CHF).
authors: Department of Radiation Oncology and Nuclear Medicine, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania 19107.
authors: C M
authors: CM
authors: Intenzo
authors: C H
authors: CH
authors: Park
authors: S M
authors: SM
authors: Kim
mesh_terms: D000368:Aged; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000453:epidemiology; D005260:Female; D006333:Heart Failure / Q000000981:diagnostic imaging* / Q000453:epidemiology; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011877:Radionuclide Imaging; D051437:Renal Insufficiency / Q000000981:diagnostic imaging*; D016284:Technetium Tc 99m Pentetate; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D016284:Technetium Tc 99m Pentetate