[Hormonal mechanisms of pathogenesis and cure of experimental gastroduodenal ulcer by the Okabe technique].
The dynamics of hormonal secretion was studied in relation with the development of an ulcer defect in rats with acetate-induced gastroduodenal ulcer after Okabe. The formation of the ulcer was accompanied by increased gastrin, glucagon, cortisol, growth hormone, and histamine secretion and reduced glucose tolerance. The level of intragastric pH reduced, the activity of proteolytic enzymes in the gastrointestinal tract increased. Correlation analysis bore evidence for the contribution of gastroenteropancreatic hormones to the compensatory-adaptational responses, whereas with a higher blood cortisol level the surface of the ulcer defect was larger. Oral mineral water (Essentuki No. 17) promoted the secretion of gastrin, glucagon, and insulin and the experimental ulcers grew smaller in this case. The involvement of the hormonal factors in the mechanisms of the development of experimental acetate-induced ulcer is discussed.
Frolkov
V K
VK
Polushina
N D
ND
Shvarts
V Ia
VIa
Kozharskiĭ
V V
VV
Zaporozhchenko
I G
IG
Kartazaeva
V A
VA
D000818:Animals; D006728:Hormones / Q000378:metabolism*; D010437:Peptic Ulcer / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar
D006728:Hormones
Gormonal'nye mekhanizmy pato- i sanogeneza éksperimental'noĭ gastroduodenal'noĭ iazvy po Okabe.