[Inhibiting effect of ADP-ribosylation by pertussis toxin on passive transport of Ca2+ into the cell membrane of porcine myometrium].
ADP-ribosylation by whooping cough toxin of protein components of inside-out oriented vesicles of pig myometrium plasma membranes under conditions of their depolarization results in significant inhibition of passive transport of Ca2+ ions. The inhibiting effect is dose- and time-dependent. rho-Chloromercuribenzoate (0.5 mM) blocks the effect of whooping cough toxin, no such effect on Ca2+ transport being observed in control preparations.
Kurskiĭ
M D
MD
Kropotova
S A
SA
Prishchepa
L A
LA
D000246:Adenosine Diphosphate Ribose / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D002413:Cations, Divalent; D002462:Cell Membrane / Q000378:metabolism; D005260:Female; D066298:In Vitro Techniques; D009215:Myometrium / Q000378:metabolism*; D037342:Pertussis Toxin; D013552:Swine; D010566:Virulence Factors, Bordetella / Q000494:pharmacology*
D002413:Cations, Divalent; D010566:Virulence Factors, Bordetella; D000246:Adenosine Diphosphate Ribose; D037342:Pertussis Toxin; D002118:Calcium
Ingibiruiushchee deĭstvie ADP-ribozilirovaniia kokliushnym toksinom napassivnyĭ transport Ca2+ v plazmaticheskoĭ membrane miometriia svin'i.