title: Local immunosuppression determined by class II HLA antigen expression in patients with preclinical cervical carcinoma.
abstract: Class II HLA antigen expression was investigated in biopsy material from patients with preclinical cervical carcinoma. Class II molecules were determined immunohistochemically by MoAb against HLA-DR antigens. A significant reduction of class II positive cells was established in the tumor tissue compared to the normal cervical epithelium. A correlation between the tumor progression and the inhibition of the class II antigen expression was found.
authors: Institute of Cell Biology and Morphology, Bulgarian Academy of Sciences, Sofia.
authors: L
authors: L
authors: Marinova-Mutafchieva
authors: G
authors: G
authors: Chakalova
mesh_terms: D000951:Antigens, Neoplasm / Q000032:analysis*; D002277:Carcinoma / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D002583:Uterine Cervical Neoplasms / Q000276:immunology*
chemical_list: D000951:Antigens, Neoplasm; D006680:HLA Antigens; D000949:Histocompatibility Antigens Class II