[Aging of the immune system and sequelae for rheumatic diseases].
Immunoreactivity is impaired in old individuals. This is due especially to a loss of signals as well as to a loss of corresponding receptors. Moreover, the regulation of the immune response is reduced. This causes an increase of infectious diseases and of autoimmunopathies. With regard to rheumatic diseases there is a significant decline of reactive states in contrast to the manifestation of autoimmune arthritis. However, this is modified by nonimmunological factors such as hormones, which explains the predominance of females.
Baenkler
H W
HW
Abt. Rheumatologie, Med. Universitätsklinik, Erlangen.
D000328:Adult; D000367:Age Factors; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000276:immunology*; D005260:Female; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007111:Immunity, Cellular / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012216:Rheumatic Diseases / Q000276:immunology*; D012737:Sex Factors
D001323:Autoantibodies
Das Altern des Immunsystems und die Folgen für rheumatische Erkrankungen.