On the subclavian steal syndrome in vitro studies.
An elastic model of the arterial system has been used in which a specially designed pumping unit simulated the heart action. Physiological pressures and normal geometry, size, and flow distribution together with the normal cardiac output and use of prosthetic heart valves are the features of the system. Atherosclerosis was simulated by introducing blockages of known cross-section at specific sites of predilection. It has been shown that, for some specific occlusion magnitude in the left or right subclavian, or in the brachycephalic arteries, the stagnant no blood flow condition will appear in the left vertebral, or the right vertebral, or right common carotid, or the right internal carotid arteries. For larger occlusions the blood flow in these arteries reverses its direction, i.e., the "steal syndrome" appears. It is shown that besides the known single steal syndrome there exists also a double steal syndrome, i.e., blood reverses its flow direction simultaneously in two arteries, both on the right side of the arterial system. This blood is taken from the circle of Willis, which at the same time is significantly supplemented by the increased blood flow through the other arteries leading into the circle of Willis.
Rodkiewicz
C M
CM
Department of Mechanical Engineering, University of Alberta, Edmonton, Canada.
Centkowski
J
J
Zajac
S
S
D001161:Arteriosclerosis / Q000503:physiopathology*; D001783:Blood Flow Velocity / Q000502:physiology; D001810:Blood Volume / Q000502:physiology; D001921:Brain / Q000098:blood supply*; D017536:Carotid Artery, Common / Q000503:physiopathology; D002941:Circle of Willis / Q000503:physiopathology; D006801:Humans; D008955:Models, Cardiovascular; D008962:Models, Theoretical; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology; D011673:Pulsatile Flow / Q000502:physiology; D013349:Subclavian Steal Syndrome / Q000503:physiopathology*; D014655:Vascular Resistance / Q000502:physiology; D014715:Vertebrobasilar Insufficiency / Q000503:physiopathology