HTLV-I associated gastric lymphoma.
A large gastric lymphoma was detected in a 42-year-old woman who was seropositive for HTLV-I. The tumor was histologically shown to be of diffuse large cell type, and phenotypic analysis revealed high expression of CD3 and CD4, indicative of a helper/inducer type of T-cell lymphoma. In Southern blot analyses, the tumor cells showed T-cell receptor re-arrangement and contained proviral DNA of HTLV-1.
Kojima
H
H
Department of Pathology, Kushiro Rohsai Hospital, Japan.
Ikeda
H
H
Kubo
T
T
Higuchi
A
A
Fujimoto
N
N
Nishibe
M
M
Nagashima
K
K
D000328:Adult; D015139:Blotting, Southern; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics; D005260:Female; D015329:Gene Rearrangement, T-Lymphocyte; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D011533:Proviruses / Q000235:genetics / Q000302:isolation & purification*; D015183:Restriction Mapping; D013274:Stomach Neoplasms / Q000235:genetics / Q000276:immunology / Q000382:microbiology / Q000473:pathology*
D004279:DNA, Viral