[The neuroendocrinological examinations in mentally retarded boy with self-injurious behavior (SIB) and the effect of naloxone, clomipramine and sulpiride on SIB].
The neuroendocrinological examinations were performed in mentally retarded 7-year-old boy with severe self-injurious behavior (SIB). The thyroid-stimulating hormone (TSH) and prolactine responses to TRH showed lower in the basal and peak levels compared with those in the age matched control group. It is suggested that there may be an enhanced dopaminergic activity. The effects of naloxone, clomipramine and sulpiride on the frequency of SIB were investigated in this case. The frequency of SIB was reduced by sulpiride; a dopamine antagonist. These data suggest dopaminergic supersensitivity and hypothalamic dysregulation as a mechanism underlying SIB.
Sugama
S
S
Department of Pediatrics Tokyo Jikei University School of Medicine, Aoto Hospital.
Kusano
K
K
Okazaki
M
M
Eto
Y
Y
D002648:Child; D002997:Clomipramine / Q000627:therapeutic use*; D006801:Humans; D008607:Intellectual Disability / Q000523:psychology*; D008297:Male; D009270:Naloxone / Q000627:therapeutic use*; D010901:Pituitary Function Tests; D016728:Self-Injurious Behavior / Q000188:drug therapy* / Q000503:physiopathology; D013469:Sulpiride / Q000627:therapeutic use*
D009270:Naloxone; D013469:Sulpiride; D002997:Clomipramine