Neuroepithelial adenocarcinoma of the eye.
A 29-year-old male patient with a microphthalmos on the right side since birth was seen in June 1987 in the University Eye Clinic because of a massive exophthalmus of the former microphthalmic eye. Computer tomography revealed a diffuse, infiltrating tumor of the right orbit. The bulbus was not demarcated, and the whole orbita had to be eviscerated. Histologically, we found a solid, undifferentiated tumor with clear signs of malignancy. It consisted of epithelial cells, partly in nest formation, which were keratin positive and vimentin negative, and of more spindle-shaped formations which were keratin negative and vimentin positive. In some areas, the tumor showed a tubular or an adenoid proliferation. CEA or S-100 could not be demonstrated. The histopathological diagnosis was neuroepithelial adenocarcinoma of the eye. The differential diagnosis and the genesis of the tumor are discussed.
Steuhl
K P
KP
Eye Clinic, University of Tübingen, FRG.
Knorr
M
M
Herzau
V
V
Pressler
H
H
D000230:Adenocarcinoma / Q000473:pathology* / Q000556:secondary; D000328:Adult; D002924:Ciliary Body / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008850:Microphthalmos / Q000473:pathology; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000473:pathology* / Q000556:secondary; D014604:Uveal Neoplasms / Q000473:pathology*