Renal excretion of urate by hyperuricaemic-hyperlipidemic patients.
We studied the renal urate excretory function in two groups of hyperuricaemic male patients composed of individuals with associated hyperlipidemia and hyperuricaemic-normolipidemic individuals, respectively. Both the hyperlipidemia and the hyperuricaemia were primary inasmuch as none of the patients studied was obese or had an above-normal alcohol intake or blood hypertension. The results obtained show that hyperuricaemic-hyperlipidemic patients have higher serum levels of uric acid and poorer urate excretion as reflected in smaller clearance and fractioned excretion of the metabolite than hyperuricaemic-normolipidemic patients. This, in turn, suggests the occurrence of differences in the extent of the urate handling anomalies between the two groups of patients.
Collantes Estevéz
E
E
Tinahones Madueño
F J
FJ
González Ruiz
A
A
Añón Barbudo
J
J
Pineda Priego
M
M
Sánchez Guijo
P
P
D000328:Adult; D000368:Aged; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D007668:Kidney / Q000378:metabolism* / Q000503:physiopathology; D007677:Kidney Function Tests; D008074:Lipoproteins / Q000097:blood / Q000145:classification; D008297:Male; D008875:Middle Aged; D014527:Uric Acid / Q000097:blood* / Q000378:metabolism*
D008074:Lipoproteins; D014527:Uric Acid