[Protective effect of antiserum to Re-LPS on experimental multiple organ failure].
We determined the possible beneficial effect of administering antiserum against Re-LPS(F515) on experimental multiple system organ failure (MSOF) in rabbits. The results showed that there were a more significant decrease of the plasma LPS level and a shorter period to recovery than in the control group after receiving antiserum to Re-LPS. Pretreatment with antiserum can remarkably improve the function of liver, lung, kidney, blood and gastrointestinal tract. The incidence of MSOF in rabbits receiving immune sera was only 11.2% and the survival rate was increased by 40.0%. The results suggest that early passive immunotherapy may neutralize gut-derived endotoxin, inhibit endotoxin-induced mediator release and prevent development of severe complication due to sepsis. Prophylactic application of antiserum to LPS core region may provide protective effect on experimental MSOF.
Yao
Y M
YM
Trauma Center, Post graduate Medical College, Hospital of People's Liberation Armg Beijing.
D000818:Animals; D004731:Endotoxins / Q000276:immunology*; D004926:Escherichia coli; D007106:Immune Sera / Q000008:administration & dosage; D007116:Immunization, Passive; D009102:Multiple Organ Failure / Q000209:etiology / Q000517:prevention & control*; D011817:Rabbits; D012771:Shock, Hemorrhagic / Q000209:etiology
D004731:Endotoxins; D007106:Immune Sera