Evaluation of monoclonal/polyclonal ratio in kidney-transplanted patients treated with cyclosporine.
Fifty-seven kidney-transplanted outpatients, treated with cyclosporine alone or associated with azathioprine, prednisone, or methylprednisolone, were submitted to a monthly follow-up in order to determine cyclosporine blood levels and the monoclonal/polyclonal (M/P) ratio. Only methylprednisolone was able to modify the M/P ratio. This drug increased the M/P ratio, suggesting a cyclosporine metabolic inhibition. This effect disappeared in a few months in spite of the continuation of methylprednisolone treatment.
Capone
D
D
Department of Human Communicative Sciences, II Faculty of Medicine, Naples, Italy.
Stanziale
P
P
Balletta
M M
MM
Imperatore
P
P
De Marino
V
V
Pisanti
N
N
D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal; D001379:Azathioprine / Q000627:therapeutic use; D002648:Child; D016572:Cyclosporine / Q000097:blood* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use
D000911:Antibodies, Monoclonal; D016572:Cyclosporine; D001379:Azathioprine; D011241:Prednisone; D008775:Methylprednisolone