title: [Brain scintigraphy (SPECT) with thallium-201 in primary brain tumors].
abstract: We evaluated the role of thallium-201 single-photon emission-computed tomography (SPECT) in diagnosis, differential diagnosis and follow-up of 33 patients with primary brain tumors. 27 of 33 lesions were detectable by Tl-201 SPECT because only two of eight low-grade (grade 1 and 2) astrocytomas showed Tl-201 accumulation up to a tumor to nontumor ratio of 2.6. High grade (grade 3 and 4) astrocytomas showed Tl-201 accumulation in the range of 2.2 up to 13.0 and were different from low-grade astrocytomas. Noninvasive grading of astrocytomas is therefore possible, whereas differential diagnosis of oligodendrogliomas and astrocytomas or meningiomas was not possible with Tl-201. In the follow-up of six patients, we could demonstrate, that tumor progression is correlated with increasing and tumor regression with decreasing Tl-201 accumulations. This functional changing proceed morphological findings in CT. But vanishing of Tl-201 accumulation during therapy does not mean vanishing of tumor as could be demonstrated by follow-up.
authors: Strahlenklinik mit Poliklinik, Klinikum Rudolf-Virchow, Charlottenburg, Freien Universität Berlin.
authors: G
authors: G
authors: Barzen
authors: C
authors: C
authors: Schubert
authors: W
authors: W
authors: Richter
authors: D
authors: D
authors: Calder
authors: M
authors: M
authors: Bärwald
authors: H
authors: H
authors: Eichstädt
authors: R
authors: R
authors: Felix
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000628:therapy; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D013794:Thallium Radioisotopes; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods* / Q000706:statistics & numerical data; D014057:Tomography, X-Ray Computed
chemical_list: D013794:Thallium Radioisotopes
vernacular_title: Hirnszintigraphie (SPECT) mit Thallium 201 bei primären Hirntumoren.