Increased concentrations of Apo B-containing triglyceride-rich lipoprotein particles in patients with chronic renal failure.
The dyslipoproteinemia of chronic renal failure (CRF) was characterized by discrete Apo B-containing lipoprotein particles separated by sequential immunoprecipitation of VLDL, IDL and LDL with antisera to Apo E and Apo C-III. CRF patients before and during dialysis had increased concentrations of Apo B-containing lipoproteins (LP) due to increased levels of triglyceride-rich LP-B:C and LP-B:C:E particles with no significant change in the levels of cholesterol-rich LP-B. Patients on hemodialysis had lower concentrations of LP-B:C and higher concentrations of LP-B:C:E than predialytic patients. The increase of Apo B-containing lipoprotein particles in CRF may contribute to atherosclerotic vascular disease and to glomerulosclerosis and progression of renal insufficiency.
Attman
P O
PO
Department of Nephrology, University of Göteborg, Sweden.
Knight-Gibson
C
C
Tavella
M
M
Samuelsson
O
O
Alaupovic
P
P
D000328:Adult; D000368:Aged; D001055:Apolipoproteins B / Q000032:analysis*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008074:Lipoproteins / Q000097:blood* / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D014280:Triglycerides / Q000032:analysis*
D001055:Apolipoproteins B; D008074:Lipoproteins; D014280:Triglycerides