title: Induction of abortion with mifepristone and misoprostol in early pregnancy.
abstract: OBJECTIVE
  To investigate the clinical efficacy of the combination of mifepristone and an orally active prostaglandin, misoprostol, for early medical termination.
  
  
  METHODS
  Women with amenorrhoea < or = 56 days were given 200 mg mifepristone. 48 h later, 600 micrograms misoprostol was given orally.
  
  
  METHODS
  Medical Termination Unit, Simpson Memorial Maternity Pavilion, Edinburgh.
  
  
  METHODS
  100 women requesting medical termination of pregnancy.
  
  
  METHODS
  Evacuation of uterus for incomplete abortion or on-going pregnancies.
  
  
  RESULTS
  One woman had an incomplete abortion prior to administration of misoprostol. 92 (93%) out of 99 women had complete abortion following administration of misoprostol. There were three on-going pregnancies (3.0%, 95% confidence limits (CL) 0.6-8.6) and four incomplete abortions with this regimen (4.0%, 95% CL 1.1-10.0). 24% women vomited and 7% had diarrhoea following administration of misoprostol. 62% did not require any analgesia.
  
  
  CONCLUSIONS
  The combination of misoprostol with mifepristone is inexpensive, simple, effective, noninvasive and an acceptable alternative to current regimens for medical termination.
authors: Department of Obstetrics and Gynaecology, University of Edinburgh, UK.
authors: K J
authors: KJ
authors: Thong
authors: D T
authors: DT
authors: Baird
mesh_terms: D000028:Abortion, Induced; D000293:Adolescent; D000328:Adult; D004334:Drug Administration Schedule; D005260:Female; D005865:Gestational Age; D006801:Humans; D015735:Mifepristone / Q000008:administration & dosage / Q000009:adverse effects; D016595:Misoprostol / Q000008:administration & dosage / Q000009:adverse effects; D010298:Parity; D011247:Pregnancy
chemical_list: D016595:Misoprostol; D015735:Mifepristone