[The effect of transfused marrow monocytes on Masugi nephritis in rabbits with radiation injury].
Sheep anti-rabbit glomerular basement membrane serum (NTS) was given to 2 groups of rabbits with a dosage of 0.8ml/kg for establishing model of crescentic glomerulonephritis. Seven days after the inoculation each rabbit received 800 rad whole body gamma-radiation in order to deplete the circulating leukocytes. Another 2 days later, all of the rabbits in group 1 received 10(8) cultivated rabbit marrow monocytes, while in group 2 nothing was given. In group 1, predominant infiltration of macrophages and cellularly crescents were obtained in the glomeruli 7 days after the administration of the cultivated cells. The Bowman's capsules were broken with crescents formation. In rabbits of group 2, there were swellings of some epithelia and endothelial cells and crescents were scanty. The result proves that the macrophages are the main factors during the formation of crescent.
Ding
X Y
XY
Department of Pathology, Sun Yat-sen University of Medical Sciences, Guangzhou.
Hu
Y F
YF
D000818:Animals; D001485:Basement Membrane / Q000648:ultrastructure; D016026:Bone Marrow Transplantation / Q000379:methods; D005921:Glomerulonephritis / Q000473:pathology*; D007106:Immune Sera; D007678:Kidney Glomerulus / Q000648:ultrastructure*; D007958:Leukocyte Count / Q000528:radiation effects; D008264:Macrophages / Q000637:transplantation; D008297:Male; D009000:Monocytes / Q000637:transplantation*; D011817:Rabbits; D011833:Radiation Injuries, Experimental / Q000473:pathology*; D014916:Whole-Body Irradiation
D007106:Immune Sera