Stability and compatibility of four anthracyclines: doxorubicin, epirubicin, daunorubicin and pirarubicin with PVC infusion bags.
A rapid isocratic technique was developed for the analysis of four anthracyclines (doxorubicin, epirubicin, daunorubicin and pirarubicin) in parenteral solutions using high pressure liquid chromatography (HPLC) with fluorescence detection and a C18 Hypersil ODS column. The availability and compatibility of these drugs from solutions infused via PVC infusion bags through PVC administration sets have been examined. No significant drug loss was observed during simulated infusions (n = 4) for 24 h using PVC infusion bags and administration sets. No significant difference was found between infusion solutions (5% glucose or 0.9% NaCl), except for pirarubicin. The reconstitution of pirarubicin in 0.9% NaCl was impossible, because we observed a precipitation of the compound in solution. The stability of the drugs was also studied in solution, in PVC bags after storage at 4 degrees C with protection from light. The results show the stability of doxorubicin, epirubicin and daunorubicin during 7 days of storage to be satisfactory, irrespective of the infusion solution (5% glucose or 0.9% NaCl). In the case of pirarubicin, the stability of the drug was satisfactory during 5 days of storage in 5% glucose, but beyond, we observed a degradation of the compound with formation of doxorubicin in the infusion solution.
Dine
T
T
Laboratoire de Pharmacologie, Faculté des Sciences Pharmaceutiques et Biologiques, Lille, France.
Cazin
J C
JC
Gressier
B
B
Luyckx
M
M
Brunet
C
C
Cazin
M
M
Goudaliez
F
F
Mallevais
M L
ML
Toraub
I
I
D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D003630:Daunorubicin / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000737:chemistry / Q000493:pharmacokinetics; D004355:Drug Stability; D015251:Epirubicin / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D007260:Infusion Pumps; D007262:Infusions, Intravenous; D011143:Polyvinyl Chloride / Q000737:chemistry*; D012996:Solutions
D000903:Antibiotics, Antineoplastic; D012996:Solutions; D015251:Epirubicin; D004317:Doxorubicin; D011143:Polyvinyl Chloride; C027260:pirarubicin; D003630:Daunorubicin