Effects of prenatal exposure to cocaine on the rest-activity cycle of the preweanling rat.
Either 45 or 60 mg/kg cocaine HCl was administered from days 8-22 of gestation. Pair-fed and nontreated groups served as controls and all treated and control litters were fostered at birth to untreated dams. To examine whether cocaine produces effects on the rest-activity cycle of the offspring, groups of three littermates from each of the treated and control groups were tested for an 8-h observation period on electronic activity monitors at 22 days of age. Neither activity level nor the rest-activity pattern were affected by cocaine. These findings are discussed in relation to previous studies of cannabis and methadone effects on the rest-activity measure.
Zmitrovich
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New York State Psychiatric Institute, Department of Developmental Psychobiology, NY 10032.
Hutchings
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Dow-Edwards
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Malowany
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D
Church
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D000818:Animals; D000833:Animals, Suckling; D003042:Cocaine / Q000494:pharmacology*; D004327:Drinking Behavior / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D008425:Maternal Behavior; D009043:Motor Activity / Q000187:drug effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar
D003042:Cocaine