[Experimental influenzal and tuberculous infections under conditions of specific and nonspecific immunosuppression].
The course of influenza and tuberculosis infections under the conditions of disturbances in the immune response of experimental animals has been studied. As revealed in the survival test, the induction of secondary T- and B-cell-mediated immunodeficiency in mice leads to an increase in the sensitivity of the body to influenza virus, especially in cases of T-cell-mediated immunodeficiency. The injection of BCG in combination with cyclophosphamide into mice induces tolerance to this antigen in the animals; this tolerance has a "split" character, i.e. it affects only T-cell-mediated, but not humoral immunity. The induction of T-cell-mediated immunodeficiency or tolerance to BCG in mice has been shown (in the survival test) to lead to the development of the sensitivity of the animals to experimental tuberculosis infection. B-cell-mediated immunodeficiency did not influence the animal survival rate.
Kondrat'eva
T K
TK
Mikheeva
N V
NV
Fontalin
L N
LN
Cherniakhovskaia
I Iu
IIu
Apt
A S
AS
Mirchink
E P
EP
Avdienko
V G
VG
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D001500:BCG Vaccine / Q000276:immunology; D003208:Concanavalin A; D003520:Cyclophosphamide; D007108:Immune Tolerance / Q000276:immunology*; D007153:Immunologic Deficiency Syndromes / Q000209:etiology / Q000276:immunology; D009980:Influenza A virus; D008070:Lipopolysaccharides / Q000276:immunology; D008297:Male; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000276:immunology* / Q000382:microbiology; D012706:Serratia marcescens; D013601:T-Lymphocytes / Q000276:immunology; D014376:Tuberculosis / Q000276:immunology*
D001500:BCG Vaccine; D008070:Lipopolysaccharides; D003208:Concanavalin A; D003520:Cyclophosphamide
Eksperimental'naia grippoznaia i tuberkuleznaia infektsii v usloviiakh spetsificheskoĭ i nespetsificheskoĭ immunosupressii.