title: Antibodies against human retinal proteins in serum from patients with cone dystrophy.
abstract: Eleven patients with cone dystrophy were examined for serum antibodies against human retinal proteins. Sera were screened by immunoblotting methods using human retinal proteins as antigens. Three cases from different families showed a distinct band at the molecular weight of 14 kDa; the hereditary pattern of these seropositive cases was autosomal recessive or sporadic with parental consanguinity. The serum antibodies were negative in the other sporadic or autosomal dominant cases of cone dystrophy with similar clinical features, in cases of various ocular diseases including macular dystrophies, and in healthy adults. No sera tested showed any specific antibodies against proteins from the human optic nerve or spinal cord.
authors: Department of Ophthalmology, Kagoshima University Faculty of Medicine, Japan.
authors: Y
authors: Y
authors: Isashiki
authors: N
authors: N
authors: Ohba
authors: M
authors: M
authors: Nakagawa
authors: Y
authors: Y
authors: Miyake
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000235:genetics / Q000276:immunology*; D003241:Consanguinity; D004596:Electroretinography; D005136:Eye Proteins / Q000235:genetics / Q000276:immunology*; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D015151:Immunoblotting; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D010786:Photoreceptor Cells / Q000276:immunology*; D012160:Retina / Q000276:immunology*; D012162:Retinal Degeneration / Q000235:genetics / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D005136:Eye Proteins