Dendrotoxin-like effects of noxiustoxin.
Noxiustoxin from the Mexican scorpion (Centruroides noxius Hoffmann) is known to block neuronal K+ channels. Noxiustoxin facilitated acetylcholine release in chick biventer cervicis nerve-muscle preparations, but not in mouse phrenic nerve-hemidiaphragm preparations. Noxiustoxin displaced binding of a radiolabelled dendrotoxin from synaptosomal membranes from rat brain, with a Ki of 10(-10) M. It is concluded that noxiustoxin shares some pharmacological properties with the K+ channel blocking dendrotoxins.
Harvey
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AL
Department of Physiology and Pharmacology, University of Strathclyde, Glasgow, U.K.
Marshall
D L
DL
Possani
L D
LD
D000818:Animals; D002642:Chick Embryo; D004546:Elapid Venoms / Q000633:toxicity*; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D051379:Mice; D009469:Neuromuscular Junction / Q000187:drug effects*; D010791:Phrenic Nerve / Q000187:drug effects; D015221:Potassium Channels / Q000187:drug effects; D051381:Rats; D012132:Respiratory Muscles / Q000187:drug effects / Q000294:innervation; D012604:Scorpion Venoms / Q000633:toxicity*; D013570:Synaptic Membranes / Q000187:drug effects; D013574:Synaptosomes / Q000187:drug effects
D004546:Elapid Venoms; D007457:Iodine Radioisotopes; D015221:Potassium Channels; D012604:Scorpion Venoms; C020273:dendrotoxin; C052567:noxiustoxin