title: [Orbital involvement in Wegener's granulomatosis].
abstract: BACKGROUND
  Granulomas of the orbit can complicate Wegener's granulomatosis (WG). If they compress the optic nerve, blindness of one or both eyes may result. Therefore, early detection and sufficient treatment are important.
  
  
  METHODS
  Computed tomography (CT) and magnetic resonance imaging (MRI) of the orbit and CNS were performed in patients suffering from WG and orbital granulomas (n = 6). The patients were seen interdisciplinary by internists, ENT-specialists, radiologists and ophthalmologists.
  
  
  RESULTS
  12 out of 121 biopsy proven WG-patients showed orbital granulomas during their disease process. Granulomas of the orbit could be best visualized by MRI. However, MRI and CT taken together were most informative. 6 patients with orbital granulomas are presented as case reports, in four of them WG lead to blindness of one eye. The course of orbital granulomas may be chronic progressive or acutely fulminant. Therapy of first choice is a high dosage, long-term immunosuppression with cyclophosphamide and prednisolone.
  
  
  CONCLUSIONS
  The detection of orbital granulomas in WG is most successful using CT and MRI. In addition to that, the analysis of visual acuity and visual field are the most important parameters in the detection and follow-up of orbital granulomas. A high dosage, long-term immunosuppression is the treatment of first choice, but in rapidly progressive cases an early decompression of the orbit has to be discussed additionally.
authors: Klinik für Ophthalmologie, Christian-Albrechts-Universität zu Kiel.
authors: G
authors: G
authors: Duncker
authors: W L
authors: WL
authors: Gross
authors: B
authors: B
authors: Nölle
authors: R
authors: R
authors: Asmus
authors: H
authors: H
authors: Koltze
authors: R P
authors: RP
authors: Spielmann
authors: E
authors: E
authors: Reinhold-Keller
authors: R
authors: R
authors: Rochels
mesh_terms: D000038:Abscess / Q000175:diagnosis / Q000188:drug therapy; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009896:Optic Atrophy / Q000175:diagnosis / Q000188:drug therapy; D009916:Orbital Diseases / Q000175:diagnosis* / Q000188:drug therapy; D014057:Tomography, X-Ray Computed; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents
vernacular_title: Orbitale Beteiligung bei Wegenerscher Granulomatose.