Controlled use of heroin in patients on methadone maintenance treatment.
The efficacy of methadone maintenance treatment was evaluated on 93 patients after 10 years of therapy. On the basis of therapeutic compliance, patients were divided into three groups: (a) 40 Total-Agreement subjects on weekly take-home methadone; (b) 28 Partial-Agreement subjects, who regularly attended the clinic daily but presented episodic positive urinalysis; (c) 25 No-Agreement patients, who were absent from the clinic more than twice a month and had a high rate of urinalysis positive for morphine. Statistical analysis, based on social adjustment improvement and criminality rate decrease, divided the 93 patients into 2 distinct categories. The first category, characterized by high social adjustment and low criminality score, included the Total- and Partial-agreement groups. The second, characterized by significantly lower social adjustment and higher criminality score, included all No-Agreement patients. This suggests that methadone treatment was able to dissociate heroin use from low social functioning. It was concluded that, in a condition of adequate compliance the episodic use of heroin is of no harm to patients on methadone maintenance therapy, that is, methadone maintenance treatment permits a controlled use of heroin.
Bianchi
E
E
Institute of Pharmacology, University of Siena, Italy.
Maremmani
I
I
Meloni
D
D
Tagliamonte
A
A
D000328:Adult; D000553:Ambulatory Care; D003417:Criminal Psychology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D003932:Heroin / Q000008:administration & dosage / Q000009:adverse effects; D006556:Heroin Dependence / Q000523:psychology / Q000534:rehabilitation*; D006801:Humans; D007558:Italy; D008297:Male; D008691:Methadone / Q000627:therapeutic use*; D010349:Patient Compliance / Q000523:psychology*; D012917:Social Adjustment; D012931:Social Environment; D015813:Substance Abuse Detection
D003932:Heroin; D008691:Methadone