Bile acid malabsorption in patients with post-vagotomy diarrhoea.
75SeHCAT scanning was evaluated as a means of detecting bile acid malabsorption in patients with postvagotomy diarrhoea. Seven day 75SeHCAT retention ratios were measured in five patients with unequivocal post-vagotomy diarrhoea. The results were compared with an age matched group of asymptomatic control patients (n = 4) each of whom had previously undergone truncal vagotomy and drainage and a further group of normal volunteers (n = 6). The median 75SeHCAT retention ratios in patients with post-vagotomy diarrhoea was 2% (range 0-9%). In contrast, the median 75SeHCAT retention ratios in asymptomatic controls was 29% (range 26-61%) and 28% (range 19-70%) in normal volunteers. These results demonstrate that there is gross bile salt malabsorption in patients with post-vagotomy diarrhoea and that 75SeHCAT scanning is an effective screening test in these patients.
al-Hadrani
A
A
Department of Surgery, Ninewells Hospital and Medical School, Dundee, Scotland, U.K.
Lavelle-Jones
M
M
Kennedy
N
N
Neill
G
G
Sutton
D
D
Cuschieri
A
A
D000293:Adolescent; D000368:Aged; D001647:Bile Acids and Salts / Q000378:metabolism*; D003967:Diarrhea / Q000000981:diagnostic imaging*; D004764:Enterohepatic Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D008286:Malabsorption Syndromes / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D012644:Selenium Radioisotopes; D013656:Taurocholic Acid / Q000031:analogs & derivatives; D015167:Vagotomy, Truncal
D001647:Bile Acids and Salts; D012644:Selenium Radioisotopes; D013656:Taurocholic Acid; C033638:23-seleno-25-homotaurocholic acid