[Efficacy of succinylcholine under hyperventilation].
To evaluate hypocapnic effect on muscle relaxant, we investigated succinylcholine under normal condition (PetCO2 5-5.5kPa) and hyperventilation (PetCO2 3-3.5kPa), with the patients as the self control. Fifteen patients undergoing selective surgery were divided randomly into two groups. The hypocapnic effect on single intubational dose course as well as sustaining two hours was observed with the neuromuscular blockade traced by accelograph. The results showed that the speed of onset, recovery time and duration of succinylcholine after 1 mg/kg i.v. have no significant difference between normal condition and hyperventilation. It is indicated that in good risk adult patients, ventilatory hypocapnia for two hours causes no significant change in succinylcholine relaxation.
Zhang
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General Hospital of People's Liberation Army.
D000293:Adolescent; D000328:Adult; D000768:Anesthesia, General; D001784:Blood Gas Analysis; D005260:Female; D006801:Humans; D016857:Hypocapnia / Q000503:physiopathology*; D008297:Male; D015409:Mastectomy, Radical; D008875:Middle Aged; D009126:Muscle Relaxation / Q000187:drug effects*; D012121:Respiration, Artificial / Q000379:methods*; D013390:Succinylcholine / Q000008:administration & dosage / Q000494:pharmacology*; D013514:Surgical Procedures, Operative
D013390:Succinylcholine