Placental transport of dioxins from mother to fetus. II. PCBs, dioxins and furans and vitamin K metabolism.
Placental transport of dioxins and furans from mother to fetus takes place. It is probably related to the fatty acid transport. Between 10 and 20% of fatty acids in a full-term baby are of maternal origin. In adipose tissue of children that died in the early neonatal period concentrations of +/- 25% were found of three dioxin and furan congeners 12378 P5CDD, 123678 H6CDD, and 23478 P5CDF in relation to a mean concentration of these congeners in the fat of 14 breastmilk samples. Data of concentrations are given as measured in liver and adipose tissue. In the placenta of a Dutch woman an accumulation of dioxins and furans is found in relation to blood. Animal studies support the hypothesis that polychlorobifenyls play a role in the cause of the late hemorrhagic disease in the newborn, in particular the 2, 4, 5, 2, 4, 5-hexachlorobifenyl that is present in relatively high concentrations in breastmilk.
Koppe
J G
JG
Department of Neonatology, University of Amsterdam, The Netherlands.
Olie
K
K
van Wijnen
J
J
D004147:Dioxins / Q000737:chemistry* / Q000506:poisoning; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005663:Furans / Q000737:chemistry* / Q000506:poisoning; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008099:Liver / Q000737:chemistry; D008431:Maternal-Fetal Exchange; D008895:Milk, Human / Q000737:chemistry; D010920:Placenta / Q000737:chemistry*; D011078:Polychlorinated Biphenyls / Q000737:chemistry* / Q000633:toxicity; D011247:Pregnancy; D014812:Vitamin K / Q000378:metabolism*
D004147:Dioxins; D005227:Fatty Acids; D005663:Furans; D014812:Vitamin K; D011078:Polychlorinated Biphenyls