Lidocaine pretreatment effectively decreases the incidence of hiccups during methohexitone administration for dilatation and curettage.
The efficacy of lidocaine 1 mg.kg-1 for prevention of methohexitone-induced hiccups was assessed in a double-blind fashion in 200 patients undergoing dilatation and curettage for pregnancy interruption. The patients were randomly assigned to receive either lidocaine 1% or saline 0.9% in a similar way (1 ml for every 10 kg of body weight). The incidence of hiccups was 16% in the control group compared to 6% in the lidocaine group. We speculate that this reduction in the methohexitone-induced hiccup ratio is related to lidocaine's membrane-stabilizing properties, which decrease the excitability of all the nervous structures involved in this reflex.
Weksler
N
N
Department of Anaesthesia, Hillel Yaffe Medical Center, Hadera, Israel.
Stav
A
A
Ovadia
L
L
Berman
M
M
Segal
A
A
Ribac
L
L
Lemberg
L
L
D000028:Abortion, Induced; D000328:Adult; D000771:Anesthesia, Intravenous; D004107:Dilatation and Curettage; D004311:Double-Blind Method; D005260:Female; D006606:Hiccup / Q000517:prevention & control*; D006801:Humans; D015994:Incidence; D008012:Lidocaine / Q000008:administration & dosage / Q000627:therapeutic use*; D008723:Methohexital / Q000009:adverse effects*; D011247:Pregnancy; D011292:Premedication
D008012:Lidocaine; D008723:Methohexital