title: Radioleucoscintigraphy in osteoarthritis. Is there an inflammatory component?
abstract: The possible contribution of an inflammatory component in osteoarthritis was investigated. There was no correlation between the percentage uptakes of 99Tcm-hexamethylpropyleneamine oxime (HMPAO)-labelled white blood cells and 99Tcm-methylene diphosphonate (MDP) and between the former and pain scores. A significant correlation was found between the percentage uptake of 99Tcm-MDP and pain scores (0.002 > P > 0.01). In osteoarthritis, 99Tcm-HMPAO-labelled white cell imaging may or may not show a positive localization in the synovial membrane. Positive white cell localization appears to be limited to the area that corresponds to the radiological evidence of the condition and the positive uptake of the skeletal imaging agent.
authors: Department of Nuclear Medicine, Royal Liverpool University Hospital, UK.
authors: M A
authors: MA
authors: al-Janabi
authors: K
authors: K
authors: Solanki
authors: M
authors: M
authors: Critchley
authors: M L
authors: ML
authors: Smith
authors: K E
authors: KE
authors: Britton
authors: E C
authors: EC
authors: Huskisson
mesh_terms: D000328:Adult; D000368:Aged; D002465:Cell Movement; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications*; D007719:Knee Joint / Q000000981:diagnostic imaging* / Q000378:metabolism; D007962:Leukocytes; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000502:physiology; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics; D010003:Osteoarthritis / Q000000981:diagnostic imaging* / Q000378:metabolism; D010091:Oximes / Q000493:pharmacokinetics; D010146:Pain / Q000209:etiology*; D011877:Radionuclide Imaging; D019690:Technetium Tc 99m Exametazime; D013669:Technetium Tc 99m Medronate / Q000493:pharmacokinetics
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D013669:Technetium Tc 99m Medronate