[The role of prostaglandins in the activity of mononuclear cells in liver cirrhosis patients].
The effect of prostaglandins (PG) E1, E2, F2 and prostacyclin in vitro on the content of cAMP and cGMP in mononuclear cells of the blood was studied in 17 patients with liver cirrhosis. PG synthesis by mononuclears from 3H-arachydonic acid was also evaluated. Patients with liver cirrhosis showing no disorders of PG synthesis by non-stimulated mononuclears and reduction of basal cAMP content revealed significant changes of functional responses of cyclase systems PG loads as well as a relative reduction of PG synthesis in conditions of stimulation with phytohemagglutinin and Ca A23187 ionophore. This is an important link in deadaptation of immune reactions in patients with liver cirrhosis.
Iagoda
A V
AV
Rekvava
R A
RA
D000328:Adult; D000368:Aged; D002478:Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D008103:Liver Cirrhosis / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009712:Nucleotides, Cyclic / Q000097:blood; D011453:Prostaglandins / Q000494:pharmacology*; D014777:Virus Diseases / Q000097:blood / Q000276:immunology
D009712:Nucleotides, Cyclic; D011453:Prostaglandins
Rol' prostaglandinov v deiatel'nosti mononuklearnykh kletok u bol'nykh tsirrozom pecheni.