Correlations between theophylline concentrations in plasma, erythrocytes and cantharides-induced blister fluid and peak expiratory flow in asthma patients.
Theophylline levels in plasma, erythrocytes and cantharides-induced blister fluid (BF) have been correlated with peak expiratory flow (PEF) in asthmatic patients. Nine asthmatic men received an IV infusion of 240 mg theophylline at a constant rate for 30 min. The theophylline concentrations in erythrocytes and blister fluid were 37% and 78% of those in plasma. There was not a strong correlation between erythrocyte or blister fluid penetration and the clinical effect of theophylline.
Philip-Joet
F
F
Pneumoallergology Department, CHU Nord, Marseille, France.
Bruguerolle
B
B
Reynaud
M
M
Arnaud
A
A
D001249:Asthma / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D001768:Blister / Q000139:chemically induced / Q000378:metabolism*; D001826:Body Fluids / Q000378:metabolism; D002193:Cantharidin; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D010366:Peak Expiratory Flow Rate / Q000187:drug effects*; D013806:Theophylline / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology
D013806:Theophylline; D002193:Cantharidin