Anthracycline gels. II. Spectroscopic study on doxorubicin-lecithin association products.
Thixotropic and thermally reversible gels have been prepared from doxorubicin-lecithin association products (DL12) by addition of salts to their aqueous solutions. The gel formation and the melting profiles have been followed by several spectroscopic techniques (1H NMR, UV-Vis, Circular Dichroism). The transition temperatures increase as the concentration of both the salt and the DL12 is increased, suggesting a progressive closer approach of the gel forming species. The process of the gel formation is cooperative and causes immobilization of the doxorubicin molecules of DL12.
Giomini
M
M
Dipartimento di Chimica, Università La Sapienza, Rome, Italy.
Giuliani
A M
AM
Giustini
M
M
Trotta
E
E
D002942:Circular Dichroism; D004317:Doxorubicin / Q000737:chemistry*; D005782:Gels; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008968:Molecular Conformation; D010713:Phosphatidylcholines / Q000737:chemistry*; D013053:Spectrophotometry / Q000379:methods; D013816:Thermodynamics
D005782:Gels; D010713:Phosphatidylcholines; D004317:Doxorubicin