Clinical picture and long-term course of epileptic seizures that occur during clozapine treatment.
Clozapine is an atypical neuroleptic drug that has proved to be effective in alleviating psychotic symptoms refractory to treatment with standard neuroleptic drugs. In addition to hematological side effects, an increased susceptibility to epileptic seizures during clozapine treatment has previously been described. In this report, we describe the clinical picture and electroencephalographic findings of 12 schizophrenic patients who have had from one to six clozapine-associated epileptic convulsions.
Liukkonen
J
J
Mikkeli Central Hospital, Finland.
Koponen
H J
HJ
Nousiainen
U
U
D000328:Adult; D002220:Carbamazepine / Q000627:therapeutic use; D002998:Clonazepam / Q000627:therapeutic use; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use; D004569:Electroencephalography / Q000187:drug effects*; D004831:Epilepsies, Myoclonic / Q000139:chemically induced* / Q000188:drug therapy; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced* / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology
D002220:Carbamazepine; D002998:Clonazepam; D003024:Clozapine