Studies on the constituents of edible and medicinal plants. III. Effects of seven limonoids on the sleeping time induced in mice by anesthetics.
Effects of seven limonoids, obakunone (1), 7 alpha-obakunol (2), 7 beta-obakunol (3), limonin (4), 7 alpha-limonol (5), 7 beta-limonol (6) and nomilin (7), on the sleeping time induced in mice by anesthetics were assayed. All the limonoids, except for 2, shortened the sleeping time induced by alpha-chloralose and urethane. 7 gave the highest reduction rate of sleeping time, and the order of the reduction rate of sleeping time was as follows; 7 > 1 and 3 > 4, 5 and 6. As the chemical structures of these compounds are similar to each other, the relationship between the structure and the effects of limonoids on sleeping time was discussed.
Wada
K
K
Faculty of Pharmaceutical Sciences, Higashi Nippon Gakuen University, Hokkaido, Japan.
Yagi
M
M
Kurihara
T
T
Haga
M
M
D000818:Animals; D002698:Chloralose / Q000494:pharmacology; D003627:Data Interpretation, Statistical; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects*; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*; D014520:Urethane / Q000494:pharmacology
D010936:Plant Extracts; D014315:Triterpenes; D002698:Chloralose; D014520:Urethane