New method for analysis of biodegradable polyesters by high-performance liquid chromatography after alkali hydrolysis.
A new method was developed for analysis of biodegradable polyesters, which involves alkali hydrolysis of polyesters to the corresponding hydroxyacids and determination of the hydroxyacids by high-performance liquid chromatography. It can be used to monitor weight change in polyesters and change in molecular ratio of the hydroxyacid constituents of polyesters during in vitro and in vivo degradation.
Kamei
S
S
Pharmaceutics Research Laboratory, Takeda Chemical Industries Ltd, Osaka, Japan.
Inoue
Y
Y
Okada
H
H
Yamada
M
M
Ogawa
Y
Y
Toguchi
H
H
D000818:Animals; D001673:Biodegradation, Environmental; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006868:Hydrolysis; D008863:Microspheres; D011091:Polyesters / Q000032:analysis*; D051381:Rats; D017207:Rats, Sprague-Dawley
D011091:Polyesters