title: Adverse cutaneous reactions associated with fluoxetine strategy for reintroduction of this drug in selected patients.
abstract: Four patients treated with fluoxetine alone developed generalized urticaria. One also suffered polyarthritis. These reactions subsided when fluoxetine was stopped. After 6-12 months, because of progressive psychiatric problems, fluoxetine was reintroduced using a desensitization protocol. In each case this was well tolerated, and fluoxetine has been continued without adverse affects for 3-10 months.
authors: Department of Medicine, St. Michael's Hospital, University of Toronto, Ontario, Canada.
authors: A
authors: A
authors: Leznoff
authors: K E
authors: KE
authors: Binkley
authors: R T
authors: RT
authors: Joffee
authors: A
authors: A
authors: Levitt
authors: M A
authors: MA
authors: Richter
mesh_terms: D000328:Adult; D002985:Clinical Protocols; D003866:Depressive Disorder / Q000188:drug therapy; D003888:Desensitization, Immunologic / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D003875:Drug Eruptions / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy; D014581:Urticaria / Q000139:chemically induced / Q000517:prevention & control
chemical_list: D005473:Fluoxetine