Tubuglomerular feedback control in long-looped nephrons. Topical minireview.
The tubuloglomerular feedback mechanism is highly activated in juxtamedullary nephrons and considered to play a major role in intrarenal regulation of glomerular filtration rate. The vasculature of juxtamedullary nephrons is highly vasoreactive with a high ability for vasodilation. This vasoreactivity is a prerequisite for an important influence of the tubuloglomerular feedback mechanism on the medullary blood flow and its regulation.
Ulfendahl
H R
HR
Department of Physiology & Medical Biophysics, University of Uppsala, Sweden.
Göransson-Nyberg
A
A
Hansell
P
P
Sjöquist
M
M
D000818:Animals; D002216:Captopril / Q000494:pharmacology; D005246:Feedback; D005919:Glomerular Filtration Rate / Q000502:physiology*; D007606:Juxtaglomerular Apparatus / Q000502:physiology*; D007671:Kidney Concentrating Ability / Q000502:physiology*; D007679:Kidney Medulla / Q000098:blood supply*; D009399:Nephrons / Q000098:blood supply*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology
D002216:Captopril; D014700:Verapamil