[The effect of carbaryl poisoning on noradrenaline (NA) levels in rat brain].
The influence of acute (50% and 20% LD50), subacute (10% LB50) and 12-week (5% LD50) intoxication with carbaryl on NA level in rat brain was investigated. The level of NA was decreased by about 40% of the control level (p > 0.001) after acute and subacute intoxication. In the subchronic study (5% LD50 for 12 weeks) carbaryl significantly decreased the NA level (p < 0.001), but after 2-week intoxication only. During the next weeks NA content remained on control level (p > 0.05). These results indicate that carbaryl causes noradrenergic alterations in rat brain, which may lead to neurotoxic action.
Jabłońska
J
J
Zakładu Toksykologii Instytutu Biofarmacji Akademii Medycznej w Warszawie.
Brzeziński
J
J
D000818:Animals; D001921:Brain / Q000187:drug effects*; D001923:Brain Chemistry; D012721:Carbaryl / Q000506:poisoning*; D007928:Lethal Dose 50; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D012721:Carbaryl; D009638:Norepinephrine
Wpływ zatrucia karbarylem na poziom noradrenaliny (NA) w mózgu szczura.