Pyoderma gangrenosum, polycythemia rubra vera, and the development of leukemia.
A patient with long-standing, well-controlled polycythemia rubra vera developed recurrent episodes of bullous pyoderma gangrenosum followed by the transformation of his hematologic disease into a rapidly progressive acute myeloid leukemia. This case, together with previously described patients, indicates that the appearance of bullous pyoderma gangrenosum in a patient with polycythemia rubra vera is often of ominous prognostic significance.
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Regional Centre of Dermatology, Mater Misericordiae Hospital, Dublin, Ireland.
Otridge
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BW
Vandenberg
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Powell
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FC
D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011087:Polycythemia Vera / Q000150:complications* / Q000473:pathology; D011379:Prognosis; D017511:Pyoderma Gangrenosum / Q000209:etiology* / Q000473:pathology; D012008:Recurrence