Preparation and diuretic properties of novel amiloride analogues.
Fifteen novel amiloride analogues were synthesized and their diuretic properties compared to amiloride and triamterene in white wistar rats. Whereas none of the 6-substituted derivatives exhibited significant natriuretic and antikaliuretic effects, five of the compounds modified in the 2-position were found equal or better than standards. The results are discussed with respect to chemical structure and physiochemical properties.
Russ
T
T
Institut für Organische Chemie, Universität Frankfurt am Main, Germany.
Ried
W
W
Ullrich
F
F
Mutschler
E
E
D000584:Amiloride / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004232:Diuretics / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D004232:Diuretics; D000584:Amiloride