Urination frequency and cystic pressure resistance after fractionated whole or partial irradiation of the rabbit urinary bladder.
Urination frequency and cystic pressure resistance have been used as end-points to assess x-ray-induced changes of bladder function. Whole or half bladders of adult male rabbits were irradiated, caudally or cranially. The absorbed dose was 33 Gy, 36 Gy or 39 Gy, given in 5 daily fractions. Animals which received a whole bladder dose of 39 Gy or 36 Gy showed increased urination frequency and enhanced bladder pressure resistance during the whole follow-up time of 100 weeks, compared with the sham-irradiated controls. At half bladder irradiation, only the highest doses (39 Gy to the cranial part of the bladder and 39 Gy or 36 Gy to the caudal part) gave rise to a slight increase in frequency at about 20 weeks after exposure.
Kohler
M
M
Institute of Medical Radiobiology, University of Zürich, Switzerland.
Eppenberger
H M
HM
Cordt-Riehle
I
I
Michel
C
C
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D008297:Male; D008365:Manometry; D011141:Polyuria / Q000209:etiology*; D011312:Pressure; D011817:Rabbits; D011836:Radiation Tolerance; D013997:Time Factors; D001743:Urinary Bladder / Q000503:physiopathology / Q000528:radiation effects*