title: 31P magnetic resonance spectroscopy of skeletal muscle in patients with fibromyalgia.
abstract: 31Phosphorous nuclear magnetic resonance (31P NMR) spectroscopy of painful calf muscle was performed in 12 patients with fibromyalgia (FS) and 7 healthy subjects during rest, aerobic and anaerobic exercising conditions, and postexercise recovery. Ratios of inorganic phosphate and creatinine phosphate (Pi/PCr) and pH were calculated from the collected 31P NMR spectra. Resting values of Pi/PCr were normal in the patients. Patients delivered only 49% of the muscle power of the controls (p = 0.005). Patients and controls had similar rates of Pi/PCr and pH changes during work and recovery. The controls were able to change their Pi/PCr and pH more than the patients, due to the greater workload reached. However, statistical significance was reached only for the anaerobic static exercise (p = 0.003). It was concluded that patients with FS have a reduced voluntary capacity for work, but normal biochemical response to work and recovery.
authors: Department of Rheumatology, Hvidovre Hospital, University of Copenhagen, Denmark.
authors: S
authors: S
authors: Jacobsen
authors: K E
authors: KE
authors: Jensen
authors: C
authors: C
authors: Thomsen
authors: B
authors: B
authors: Danneskiold-Samsoe
authors: O
authors: O
authors: Henriksen
mesh_terms: D000328:Adult; D003404:Creatinine / Q000032:analysis; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D005356:Fibromyalgia / Q000145:classification / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000473:pathology* / Q000502:physiology; D010146:Pain / Q000473:pathology; D010758:Phosphorus / Q000032:analysis; D010807:Physical Endurance / Q000502:physiology; D012146:Rest / Q000502:physiology; D013223:Statistics as Topic
chemical_list: D010758:Phosphorus; D003404:Creatinine