title: Striatal subregions are differentially vulnerable to the neurotoxic effects of methamphetamine.
abstract: Methamphetamine (m-AMPH) or saline was repeatedly administered to rats. One week later, the caudate-putamen of the m-AMPH-treated rats revealed a decrease in both [3H]mazindol-labeled dopamine uptake sites and tissue dopamine content. Moreover, the resulting pattern of decline in these measures was regionally heterogeneous. The ventral caudate-putamen displayed the greatest decrease in both [3H]mazindol binding and dopamine content while the neighboring nucleus accumbens and the dorsal caudate-putamen remained relatively intact. These results indicate a regional difference in the susceptibility of striatal dopaminergic terminals to the neurotoxic effects of methamphetamine.
authors: Department of Psychobiology, University of California, Irvine 92717-4550.
authors: A J
authors: AJ
authors: Eisch
authors: M
authors: M
authors: Gaffney
authors: F B
authors: FB
authors: Weihmuller
authors: S J
authors: SJ
authors: O'Dell
authors: J F
authors: JF
authors: Marshall
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D003342:Corpus Striatum / Q000187:drug effects*; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D008694:Methamphetamine / Q000633:toxicity*; D011869:Radioligand Assay; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D008694:Methamphetamine; D004298:Dopamine