title: [Potential cardiotonics. 15. Crystal modifications of 3-cyano-2-morpholino-5-(4-pyridinyl)pyridine (AWD 122-14)].
abstract: The preparation and X-ray crystallographic characterisation of 10 polymorphic or pseudo-polymorphic forms of the novel cardiotonic AWD 122-14 are described. Thermic transformations of some polymorphic forms into the alpha-form was proved by thermogravimetric analysis and powder diffraction pattern. In dissolution behaviour no significant differences were found between the crystalline modifications but with regard to galenic processing compact alpha-, gamma- and epsilon-forms show advantages.
authors: Forschungsinstitut für Molekulare Pharmakologie, Berlin.
authors: V
authors: V
authors: Hagen
authors: G
authors: G
authors: Reck
authors: M
authors: M
authors: Dathe
authors: H J
authors: HJ
authors: Jänsch
authors: M
authors: M
authors: Feist
mesh_terms: D002316:Cardiotonic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D009025:Morpholines / Q000138:chemical synthesis* / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D002316:Cardiotonic Agents; D009025:Morpholines; D011725:Pyridines; C077469:3-cyano-2-morpholino-5-(pyrid-4-yl)pyridine
vernacular_title: Potentielle Kardiotonika. 15. Mitteilung: Kristallmodifikationen von 3-Cyan-2-morpholino-5-(pyrid-4-yl)pyridin (AWD 122-14).