[Diffusion of amikacin into the sinuses in patients with nosocomial sinusitis. Administration of a single dose per day].
Twenty mechanically ventilated patients with nosocomial sinusitis were treated with amikacin 15 mg/kg administered either once a day (group 1 patients) or twice a day (group 2 patients). Amikacin was assayed in serum and in the liquid drained from the sinuses 8 times over a 24 hours' period (group 1) or 7 times over a 12 hours' period (group 2). The amikacin concentration peak was 10.9 mg/l in group 1 and 5.1 mg/l in group 2. It is concluded that amikacin can be used to treat patients with nosocomial sinusitis. High amikacin concentrations are reached with the once a day dosage.
Holzapfel
L
L
Service de Réanimation, Centre Hospitalier, Bourg-en-Bresse.
Villette
P
P
Ohen
F
F
Madinier
G
G
Demingeon
G
G
Clément
C
C
D000328:Adult; D000368:Aged; D000583:Amikacin / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D001442:Bacteroides Infections / Q000188:drug therapy / Q000382:microbiology; D003428:Cross Infection / Q000188:drug therapy* / Q000382:microbiology; D004058:Diffusion; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010256:Paranasal Sinuses / Q000187:drug effects*; D012852:Sinusitis / Q000188:drug therapy* / Q000382:microbiology; D013290:Streptococcal Infections / Q000188:drug therapy / Q000382:microbiology
D000583:Amikacin
Diffusion de l'amikacine dans les sinus chez les malades ayant une sinusite nosocomiale. Administration en dose unique journalière.