Effects of three compounds extracted from Morinda lucida on Plasmodium falciparum.
The effects of three compounds, digitolutein (1), rubiadin 1-methyl ether (2) and damnacanthal (3) extracted from the stem bark and the roots of Morinda lucida Benth. on the growth of Plasmodium falciparum in vitro were investigated. The number of parasites (schizonts) decreased significantly in a dose-dependent manner, and 100% of inhibition was obtained with 30 to 40 micrograms of each compound tested. The IC50 values were calculated.
Koumaglo
K
K
Département de Chimie, Université du Bénin, Lomé, Togo.
Gbeassor
M
M
Nikabu
O
O
de Souza
C
C
Werner
W
W
D000818:Animals; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects*
D000880:Anthraquinones; D000962:Antimalarials; C079170:damnacanthal; C079171:digitolutein; C079172:rubiadin 1-methyl ether