Food immediate-contact hypersensitivity (FICH) and elimination diet in young children with atopic dermatitis. Preliminary results in 107 children.
In atopic dermatitis [AD], not only food consumption, but direct skin-contact too can provoke hypersensitivity reactions. We imitated food immediate-contact hypersensitivity [FICH] to cow's milk, egg, peanut or soy by a skin provocation test. This skin application food test [SAFT] was applied in 91 patients aged up to 5 years and suffering from AD, and in 16 healthy controls (all SAFT-negative). In the SAFT-positive patients (n = 61), FICH to egg was observed in 72%, to cow's milk in 47%, to peanut in 34% and soy in only 1 patient. SAFT and RAST scores correlated weakly. Nevertheless, many discrepancies between SAFT and RAST results were found. In 20 of the 61 (33%) patients with FICH, a flare-up in AD was noted at SAFT testing. Upon introducing dietary restrictions, AD improved impressively in 9 of 23 patients who could be followed up. FICH is an important symptom in children with AD and food allergy.
Oranje
A P
AP
Department of Dermato-Venereology, Erasmus University, Rotterdam, The Netherlands.
Aarsen
R S
RS
Mulder
P G
PG
van Toorenenbergen
A W
AW
Liefaard
G
G
Dieges
P H
PH
D010367:Arachis / Q000009:adverse effects; D002675:Child, Preschool; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000178:diet therapy* / Q000276:immunology; D003876:Dermatitis, Atopic / Q000175:diagnosis / Q000178:diet therapy* / Q000276:immunology; D004531:Eggs / Q000009:adverse effects; D005512:Food Hypersensitivity / Q000175:diagnosis / Q000178:diet therapy* / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D007223:Infant; D016269:Milk Hypersensitivity / Q000175:diagnosis; D011852:Radioallergosorbent Test; D012882:Skin Tests
D007073:Immunoglobulin E