[Alpha-interferon therapy: an echographic study of left ventricular function and a clinical assessment of cardiovascular complications].
Many side-effects of alpha interferon (alpha-I) therapy have occurred as a result of its widespread clinical applications. The hypothesis of alpha-I related cardiomyopathy is particularly interesting. Our study involved echocardiographic evaluation of left ventricular function and cardiovascular complications in 35 patients with chronic hepatitis treated with alpha-I at 20 MU/week for an average of 10.8 months. The results were compared with those of a control group. Of the values studied, only Max E V and the E/A ratio were statistically significant. No cardiovascular side-effects were found.
Tarquinii
M
M
Servizio di Cardiologia, Policlinico S. Orsola, Malpighi di Bologna.
Lolli
C
C
Foscoli
M
M
Pinto
A
A
Mazzella
G
G
Labriola
E
E
Roda
E
E
Toschi
G P
GP
D000328:Adult; D002319:Cardiovascular System / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000503:physiopathology; D002908:Chronic Disease; D004341:Drug Evaluation; D004452:Echocardiography; D015150:Echocardiography, Doppler; D005260:Female; D006505:Hepatitis / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D016277:Ventricular Function, Left / Q000187:drug effects*
D016898:Interferon-alpha
Terapia con alfa interferone: studio ecocardiografico della funzione ventricolare sinistra e valutazione clinica delle complicanze cardiovascolari.