Generation of mutant mice lacking surface expression of CD4 or CD8 gene targeting.
With the use of homologous recombination in embryonic stem cells, two new strains of mice lacking surface CD4 or CD8 expression have been generated. It is hoped that they will be useful mouse strains for the study of autoimmune diseases, tissue transplantation rejections and tumour rejections.
Mak
T W
TW
Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Toronto, Canada.
Rahemtulla
A
A
Schilham
M
M
Koh
D R
DR
Fung-Leung
W P
WP
D000818:Animals; D000950:Antigens, Ly / Q000096:biosynthesis / Q000235:genetics*; D001327:Autoimmune Diseases; D015704:CD4 Antigens / Q000096:biosynthesis / Q000235:genetics*; D016827:CD8 Antigens / Q000096:biosynthesis / Q000235:genetics*; D004195:Disease Models, Animal; D005091:Exons; D005786:Gene Expression Regulation; D007111:Immunity, Cellular; D051379:Mice / Q000196:embryology; D008817:Mice, Mutant Strains / Q000235:genetics / Q000276:immunology*; D016254:Mutagenesis, Insertional; D011995:Recombination, Genetic; D013234:Stem Cells; D014181:Transplantation Immunology
D000950:Antigens, Ly; D015704:CD4 Antigens; D016827:CD8 Antigens