title: Changes of splenic lymphocyte subpopulation in mice inoculated with Babesia microti and Babesia rodhaini.
abstract: Changes of splenic lymphocyte subpopulation after Babesia microti and Babesia rodhaini inoculation in mice were examined by flow cytometric analysis. The B. microti inoculated mice showed a longer period of time from inoculation to the onset of increase or decrease parasitaemia (%), packed cell volume, total spleen cell numbers and surface immunoglobulin positive splenic cell numbers than respective periods in B. rodhaini inoculated mice. The Thy-1 positive cell numbers in B. microti inoculated mice and B. rodhaini inoculated mice pre-immunized with homologous parasites were significantly higher than that of B. rodhaini inoculated mice. The ratio of L3T4 positive cell/Lyt-2 positive cell after inoculation with B. microti was quite similar to that in B. rodhaini mice pre-immunized. However, the ratio in B. rodhaini inoculated mice revealed a lack of an increasing phase. These results suggested that the T-cell dependent early immune response, especially suppressor activity, was closely related to the difference in the course of infection between the non-lethal B. microti and the lethal B. rodhaini infection in mice.
authors: Department of Veterinary Clinical Pathobiology, University of Tokyo, Japan.
authors: T
authors: T
authors: Shimada
authors: S
authors: S
authors: Shikano
authors: K
authors: K
authors: Ono
authors: A
authors: A
authors: Saito
authors: N
authors: N
authors: Suzuki
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000096:biosynthesis; D001403:Babesia / Q000276:immunology; D001404:Babesiosis / Q000276:immunology*; D005434:Flow Cytometry / Q000662:veterinary; D007958:Leukocyte Count / Q000662:veterinary; D016131:Lymphocyte Subsets; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology* / Q000469:parasitology; D012376:Rodent Diseases / Q000276:immunology* / Q000469:parasitology; D013154:Spleen / Q000166:cytology*
chemical_list: D000913:Antibodies, Protozoan