N-methyl-D-aspartate injection into the massa intermedia facilitates development of limbic kindling in rats.
The effect on limbic kindling of N-methyl-D-aspartate (NMDA) injection into the midline thalamus of rats was investigated. Repeated injection of 25 nmol/0.5 microliters NMDA (experimental group) into the massa intermedia (MI), particularly into the reuniens nucleus, caused tonic and/or clonic generalized convulsion associated with temporal limbic EEG seizure discharge. This did not occur after injection of phosphate-buffered saline (PBS, control group). When the animals were subjected to subsequent kindling at either the hippocampus (HP) or the amygdala (AM), only the experimental group showed a significant facilitation of kindling rate. The results suggest that an NMDA receptor in the reuniens nucleus participates in modulation of temporal limbic excitability and seizure development.
Hirayasu
Y
Y
Division of Neurosciences, University of British Columbia, Vancouver, Canada.
Wada
J A
JA
D000679:Amygdala / Q000502:physiology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D006624:Hippocampus / Q000502:physiology; D007696:Kindling, Neurologic / Q000187:drug effects* / Q000502:physiology; D008032:Limbic System / Q000502:physiology*; D008297:Male; D008845:Microinjections; D016202:N-Methylaspartate / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D012640:Seizures / Q000209:etiology* / Q000503:physiopathology; D013788:Thalamus / Q000187:drug effects* / Q000502:physiology
D016194:Receptors, N-Methyl-D-Aspartate; D016202:N-Methylaspartate