Physiologic effects of administration of interleukin 1 beta in cows.
The immunomodulating polypeptide interleukin 1 beta (IL-1 beta) has been shown to be homologous to osteoclast-activating factor and is capable of stimulating increased osteoclastic bone resorption. This effect prompted an investigation into the potential use of IL-1 beta for prevention of parturient paresis, a disease of dairy cows characterized by hypocalcemia and poor osteoclastic resorption of bone. Six nonpregnant cows were treated with a high dosage of IL-1 beta (166 ng/kg of body weight) every 8 hours for 4 days. The IL-1 beta treatment significantly (P < 0.05) increased urinary hydroxyproline excretion, an index of osteoclast activity, indicating that bone calcium resorption might be stimulated by IL-1 beta treatment of cows. However, IL-1 beta treatment also caused transient fever, inappetence, increased pulse and respiratory rate, and diuresis. The acute, but transient, effect of IL-1 beta treatment was to cause a decrease in plasma calcium and phosphorus concentrations. The pleiotropic effects of IL-1 beta administration negated the positive effects on osteoclastic bone resorption, and indicates that this cytokine may be of minimal benefit for prevention of parturient paresis.
Goff
J P
JP
USDA, Agricultural Research Service, National Animal Disease Center, Ames, IA 50010.
Naito
Y
Y
Kehrli
M E
ME
Hayes
P
P
Daley
M
M
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002417:Cattle / Q000378:metabolism / Q000502:physiology*; D005260:Female; D006706:Homeostasis / Q000502:physiology; D007375:Interleukin-1 / Q000009:adverse effects / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology; D014556:Urine / Q000737:chemistry
D007375:Interleukin-1; D011994:Recombinant Proteins; D002118:Calcium