Case report of primary cardiac lymphoma. The applications of PCR to the diagnosis of primary cardiac lymphoma.
A 75-year-old man initially complained of pollakiuria and low abdominal pain, and died of massive bleeding from an exacerbated gastric ulcer. The diagnosis of primary cardiac lymphoma was made postmortem. The tumor involved only the epicardium and myocardium, which met the criteria of primary cardiac lymphoma as defined by the Armed Forces Institute of Pathology. The lymphoma consisted of large cells and expressed the B cell marker, CD20. Although chronic inflammation due to chronic renal failure was observed in the pericardium around the lymphoma, polymerase chain reaction (PCR) was conducted to detect monoclonality at the DNA level in lymphoma cells, which were shown to comprise a monoclonal population.
Kasai
K
K
Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan.
Kuwao
S
S
Sato
Y
Y
Murayama
M
M
Harano
Y
Y
Kameya
T
T
D000368:Aged; D001483:Base Sequence; D014408:Biomarkers, Tumor / Q000032:analysis; D004273:DNA, Neoplasm / Q000032:analysis; D006338:Heart Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008223:Lymphoma / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology*; D008297:Male; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction / Q000379:methods
D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm