Inhibition of afferent vagus nerves decreases gastric stress lesions.
Capsaicin (Sigma Chemical Co.) is a unique chemical agent that causes degeneration of afferent nerve fibers. Previous conclusions about Capsaicin effects on the gastric mucosal response to stress have not precisely defined which afferent nerves were affected. Therefore, the aim of the first portion of this study was to define the origin of afferent vagus nerves to the anterior gastric wall after injections of fluorogold (which is an axonal tracer) into the stomach. The second part of this study was to compare the stress effects on the gastric mucosa in rats with impaired afferent nerve function after Capsaicin treatment.
Sugitani
A
A
Department of Surgery, University of Illinois, Chicago.
Donahue
P E
PE
Doyle
M D
MD
Newson
B L
BL
Nyhus
L M
LM
D000208:Acute Disease; D000818:Animals; D002211:Capsaicin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002908:Chronic Disease; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005260:Female; D005753:Gastric Mucosa / Q000294:innervation; D009475:Neurons, Afferent / Q000187:drug effects*; D010437:Peptic Ulcer / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013312:Stress, Physiological / Q000150:complications*; D014630:Vagus Nerve / Q000033:anatomy & histology / Q000187:drug effects*
D002211:Capsaicin