title: Pathological lesions following an experimental intoxication with aflatoxin B1 in broiler chickens.
abstract: A follow-up of chickens dosed orally over 21 days with 0.2 and 3 micrograms of aflatoxin B1 (AFB1) g-1 of bodyweight daily and their subsequent recovery 10 days after withdrawal of contaminated food was conducted. Vacuolation of liver cells during the initial days of the intoxication and cellular depletion in the follicle medulla of the bursa of Fabricius were the lesions which appeared first and persisted during the recovery phase in both groups of intoxicated animals. The intensity of these lesions and their persistence was related to the dose of aflatoxin ingested. A significant reduction in the bodyweight and absolute weights of liver, bursa of Fabricius spleen and thyroid was observed in the higher dose group.
authors: Department of Veterinary Medicine, Faculty of Veterinary Science, Universitat Autònoma de Barcelona, Bellaterra, Spain.
authors: Y
authors: Y
authors: Espada
authors: M
authors: M
authors: Domingo
authors: J
authors: J
authors: Gomez
authors: M A
authors: MA
authors: Calvo
mesh_terms: D016604:Aflatoxin B1 / Q000633:toxicity*; D000818:Animals; D002645:Chickens; D009929:Organ Size / Q000187:drug effects; D009928:Organ Specificity; D011201:Poultry Diseases / Q000139:chemically induced / Q000401:mortality / Q000473:pathology*; D013997:Time Factors
chemical_list: D016604:Aflatoxin B1