Molecular basis of the efficacy of cefaclor against Haemophilus influenzae.
Cefaclor sustained its inhibitory activity against a beta-lactamase-producing strain of Haemophilus influenzae. Although a relatively high permeability coefficient was calculated for ampicillin compared with that calculated for cefaclor, the resulting periplasmic concentration of cefaclor was 5.7 times that of ampicillin. The efficacy of cefaclor may be due to its higher beta-lactamase resistance, which allows it to achieve a greater periplasmic concentration and adequate binding to crucial penicillin-binding proteins.
Picard
M
M
Département de Microbiologie and Laboratorie, Centre Hospitalier de l'Université Laval, Québec, Canada.
Malouin
F
F
D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology; D001426:Bacterial Proteins; D001667:Binding, Competitive; D002352:Carrier Proteins / Q000378:metabolism; D002433:Cefaclor / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology*; D002463:Cell Membrane Permeability; D002509:Cephaloridine / Q000493:pharmacokinetics; D002512:Cephalothin / Q000493:pharmacokinetics; D006193:Haemophilus influenzae / Q000187:drug effects* / Q000378:metabolism; D006602:Hexosyltransferases; D007457:Iodine Radioisotopes; D007700:Kinetics; D002267:Muramoylpentapeptide Carboxypeptidase / Q000378:metabolism; D010404:Penicillin V / Q000378:metabolism; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases; D001618:beta-Lactamases / Q000378:metabolism
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002352:Carrier Proteins; D007457:Iodine Radioisotopes; D046915:Penicillin-Binding Proteins; D002433:Cefaclor; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase; D001618:beta-Lactamases; D002509:Cephaloridine; D002512:Cephalothin; D010404:Penicillin V