title: Correlation between ovarian steroids and lipid fractions in relation to age in premenopausal women.
abstract: OBJECTIVE
  We evaluated the effect of sex steroids on the lipid fractions (cholesterol, triglycerides, LDL-C, HLD-C and subfractions HDL2-C and HDL3-C) and on the apolipoproteins (A-1 and B) in relation to age in women.
  
  
  METHODS
  Twenty-eight normally cycling women belonging to three age groups (20-29, n = 11; 30-39, n = 10; 40-49, n = 7) had blood samples taken daily during one cycle.
  
  
  METHODS
  Serum lipid fractions, apolipoproteins (Apo) and ovarian steroids were measured daily during the menstrual cycle. Diet and exercise were also evaluated.
  
  
  RESULTS
  Each age group had comparable profiles for daily serum concentrations of oestradiol, progesterone and testosterone. There were no significant variations of the lipid fractions or of the ApoA-I and ApoB during the menstrual cycle in each group. Using regression analysis, modifications of cholesterol, triglycerides, LDL-C and ApoB were partially but significantly correlated with age. These changes occurred in spite of similar serum concentrations of oestradiol, progesterone and testosterone in the three groups. Lipid fractions were also affected by the increase of body mass index with age, especially HDL-C and HDL2C. However, there were no differences in lipid and energy intake or in energy expenditure during physical leisure activities.
  
  
  CONCLUSIONS
  These results indicate that physiological fluctuations of ovarian steroids have no effects on lipids and Apo in normally cycling women of increasing age. In this study, the age related changes in the lipid fractions were partially correlated with body mass index but not with energy intake or exercise.
authors: Saint-François d'Assise Research Center, Québec, Canada.
authors: N A
authors: NA
authors: Brideau
authors: J C
authors: JC
authors: Forest
authors: A
authors: A
authors: Lemay
authors: S
authors: S
authors: Dodin
mesh_terms: D000328:Adult; D000375:Aging / Q000097:blood*; D001053:Apolipoproteins / Q000097:blood; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008598:Menstruation / Q000097:blood; D008875:Middle Aged; D011374:Progesterone / Q000097:blood; D013739:Testosterone / Q000097:blood; D014280:Triglycerides / Q000097:blood
chemical_list: D001053:Apolipoproteins; D008078:Cholesterol, LDL; D012739:Gonadal Steroid Hormones; D008055:Lipids; D014280:Triglycerides; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D002784:Cholesterol