title: Absorption of polar drugs following caecal instillation in healthy volunteers.
abstract: We have investigated colonic drug absorption in man by the caecal instillation of a multi-component solution of atenolol, cimetidine, frusemide, hydrochlorothiazide and salicylic acid. We found that salicylic acid absorption from this solution was delayed but complete whereas the absorption of atenolol, cimetidine, frusemide and hydrochlorothiazide was four- to five-fold lower than expected from oral bioavailability studies.
authors: Department of Medicine, Hope Hospital, Manchester, UK.
authors: S A
authors: SA
authors: Riley
authors: M
authors: M
authors: Kim
authors: F
authors: F
authors: Sutcliffe
authors: M
authors: M
authors: Rowland
authors: L A
authors: LA
authors: Turnberg
mesh_terms: D000328:Adult; D001262:Atenolol / Q000493:pharmacokinetics; D001682:Biological Availability; D002432:Cecum / Q000378:metabolism; D002927:Cimetidine / Q000493:pharmacokinetics; D003106:Colon / Q000378:metabolism*; D005260:Female; D005665:Furosemide / Q000493:pharmacokinetics; D006801:Humans; D006852:Hydrochlorothiazide / Q000493:pharmacokinetics; D007082:Ileum / Q000378:metabolism; D007322:Instillation, Drug; D007408:Intestinal Absorption / Q000502:physiology*; D007583:Jejunum / Q000378:metabolism; D008297:Male; D010477:Perfusion; D010599:Pharmacokinetics; D012459:Salicylates / Q000493:pharmacokinetics; D020156:Salicylic Acid
chemical_list: D012459:Salicylates; D006852:Hydrochlorothiazide; D001262:Atenolol; D005665:Furosemide; D002927:Cimetidine; D020156:Salicylic Acid