Adrenal function of children with bronchial asthma treated with beclomethasone dipropionate.
The function of the hypothalamic-pituitary-adrenal (HPA) axis was investigated in nine asthmatic children treated by inhalation of beclomethasone dipropionate (300 micrograms/day) for 12 weeks. The trial was designed as a prospective study. The 24-hour urinary free cortisol, serum cortisol, response to ACTH, and nocturnal serum cortisol followed by 20-minute sampling were measured before and after the study period. No significant changes were found, suggesting that inhaled beclomethasone, in a daily dose of 300 micrograms, does not cause suppression of the HPA axis.
Katsunuma
T
T
Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan.
Akasawa
A
A
Iikura
Y
Y
D000280:Administration, Inhalation; D000293:Adolescent; D000311:Adrenal Glands / Q000502:physiology*; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001507:Beclomethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D008297:Male; D010913:Pituitary-Adrenal System / Q000502:physiology
D001507:Beclomethasone