Pergolide can induce soluble superoxide dismutase in rat striata.
Pergolide, a dopamine receptor agonist, given daily i.p. for three weeks at 0.04 mg/kg and 0.4 mg/kg, significantly induced soluble (Cu-Zn) superoxide dismutase in the rat striatum, while having no effect on the mitochondrial (Mn) form of the enzyme. Such induction, which can also be effected by (-)-deprenyl, may help to protect against nigrostriatal degeneration.
Clow
A
A
Division of Biomedical Science, Polytechnic of Central London, United Kingdom.
Hussain
T
T
Glover
V
V
Sandler
M
M
Walker
M
M
Dexter
D
D
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D003342:Corpus Striatum / Q000187:drug effects / Q000201:enzymology*; D003600:Cytosol / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004790:Enzyme Induction / Q000187:drug effects; D007510:Isatin / Q000494:pharmacology; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology; D010479:Pergolide / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012642:Selegiline / Q000494:pharmacology; D013347:Subcellular Fractions / Q000187:drug effects / Q000378:metabolism; D013482:Superoxide Dismutase / Q000096:biosynthesis*
D010479:Pergolide; D012642:Selegiline; D007980:Levodopa; D007510:Isatin; D013482:Superoxide Dismutase; D004298:Dopamine