The gene for leukocyte antigen-related tyrosine phosphatase (LAR) is localized to human chromosome 1p32, a region frequently deleted in tumors of neuroectodermal origin.
In situ hybridization was employed to localize a cDNA probe from the human protein tyrosine phosphatase gene LAR to human metaphase chromosomes. LAR, a putative tumor suppressor gene, has been localized to 1p32, a chromosomal region that is frequently found deleted in human neuroblastoma and pheochromocytoma.
Jirik
F R
FR
Biomedical Research Centre, University of British Columbia, Vancouver, Canada.
Harder
K W
KW
Melhado
I G
IG
Anderson
L L
LL
Duncan
A M
AM
D000310:Adrenal Gland Neoplasms / Q000235:genetics*; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D017353:Gene Deletion; D016147:Genes, Tumor Suppressor; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D017403:In Situ Hybridization; D009447:Neuroblastoma / Q000235:genetics*; D010673:Pheochromocytoma / Q000235:genetics*; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D054630:Receptor-Like Protein Tyrosine Phosphatases, Class 4; D011956:Receptors, Cell Surface
D006023:Glycoproteins; D011956:Receptors, Cell Surface; C516841:PTPRA protein, human; D017027:Protein Tyrosine Phosphatases; D054630:Receptor-Like Protein Tyrosine Phosphatases, Class 4