Plasma prolactin as a predictor of relapse in drug-free schizophrenic outpatients.
A low plasma prolactin concentration has been reported to be associated with an increased risk of subsequent relapse in patients with schizophrenia. Prolactin concentration was measured in samples from stable schizophrenic men who were outpatients just prior to neuroleptic withdrawal. No relationship between prolactin concentration and time to subsequent relapse was found. Prolactin concentration may predict time to relapse only in populations characterized by specific demographic features or medication history.
Kirkpatrick
B
B
University of Maryland School of Medicine, Baltimore.
Carpenter
W T
WT
Maeda
K
K
Buchanan
R W
RW
Breier
A
A
Tamminga
C A
CA
D000284:Administration, Oral; D000328:Adult; D001921:Brain / Q000503:physiopathology; D004298:Dopamine / Q000502:physiology; D005476:Fluphenazine / Q000008:administration & dosage / Q000009:adverse effects; D006220:Haloperidol / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008297:Male; D011388:Prolactin / Q000097:blood*; D011569:Psychiatric Status Rating Scales; D012008:Recurrence; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D014268:Trifluoperazine / Q000008:administration & dosage / Q000009:adverse effects
D014268:Trifluoperazine; D011388:Prolactin; D006220:Haloperidol; D005476:Fluphenazine; D004298:Dopamine