title: Stability of refraction and visual acuity during 5 years in eyes with simple myopia. The PERK Study Group.
abstract: BACKGROUND
  Normal ranges of variability of refraction and visual acuity in adult myopic eyes are needed as a reference standard for assessing the stability of refractive corneal surgery.
  
  
  METHODS
  We measured the changes in spectacle-corrected visual acuity and cycloplegic refraction during 5 years for the unoperated eye of 82 patients aged 21 to 57 years in the Prospective Evaluation of Radial Keratotomy Study. The changes were compared for contact lens and non-contact lens wearers. We also compared the 5-year cycloplegic and manifest refractions for these unoperated eyes.
  
  
  RESULTS
  Of 77 eyes, 44% gained or lost one Snellen line and 48% experienced no change in spectacle-corrected visual acuity between baseline and 5 years. Only one eye (1%) lost two lines, and 7% gained two lines. The refractive change was less than 1.00 D for 84% of the 37 non-contact lens wearing eyes. Only 13% became more myopic by at least 1.00 D (maximum increase in myopia, 2.00 D), and 3% became less myopic by 1.00 D. Of 45 contact lens wearing eyes, 38% became more myopic by at least 1.00 D. The 5-year manifest refraction was 0.50 D to 1.50 D more myopic than the cycloplegic refraction for 37% of eyes.
  
  
  CONCLUSIONS
  We recommend using two or more Snellen lines as the standard for a meaningful change in spectacle-corrected visual acuity in operated eyes, and 1.00 D as a meaningful cutoff for stability of refraction. The wearing of contact lenses can confound the results of stability studies. The difference between the cycloplegic and manifest refractions suggests that the cycloplegic refraction should be used in planning for refractive surgery.
authors: Division of Biostatistics, Emory University School of Public Health, Atlanta, GA 30329.
authors: A
authors: A
authors: Nizam
authors: G O
authors: GO
authors: Waring
authors: M J
authors: MJ
authors: Lynn
authors: M A
authors: MA
authors: Ward
authors: P A
authors: PA
authors: Asbell
authors: H D
authors: HD
authors: Balyeat
authors: E
authors: E
authors: Cohen
authors: W
authors: W
authors: Culbertson
authors: D J
authors: DJ
authors: Doughman
authors: P
authors: P
authors: Fecko
mesh_terms: D000328:Adult; D003261:Contact Lenses; D005069:Evaluation Studies as Topic; D005139:Eyeglasses; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009216:Myopia / Q000503:physiopathology* / Q000628:therapy; D012029:Refraction, Ocular; D015203:Reproducibility of Results; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology*