L-dopa inhibits in vitro phosphorylation of melanoma glycoproteins.
L-DOPA had no effect on the endogenous phosphorylation of proteins after extraction with 1% Triton X-100 from hamster melanoma. When proteins were purified further by wheat germ-agglutinin chromatography, however, a dramatic and dose-dependent inhibitory effect of DOPA on glycoprotein phosphorylation was observed in the presence of Mn+2.
Slominski
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A
Department of Microbiology, Immunology and Molecular Genetics, Albany Medical College, New York 12208.
Friedrich
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T
D000818:Animals; D002845:Chromatography; D006224:Cricetinae; D006023:Glycoproteins / Q000378:metabolism*; D007980:Levodopa / Q000494:pharmacology*; D008543:Melanins / Q000096:biosynthesis; D008546:Melanoma, Experimental / Q000378:metabolism*; D008970:Molecular Weight; D017830:Octoxynol; D010766:Phosphorylation; D011092:Polyethylene Glycols; D014407:Tumor Cells, Cultured; D014909:Wheat Germ Agglutinins
D006023:Glycoproteins; D008543:Melanins; D014909:Wheat Germ Agglutinins; D011092:Polyethylene Glycols; D007980:Levodopa; D017830:Octoxynol