[Potential cardiotonics. 15. Crystal modifications of 3-cyano-2-morpholino-5-(4-pyridinyl)pyridine (AWD 122-14)].
The preparation and X-ray crystallographic characterisation of 10 polymorphic or pseudo-polymorphic forms of the novel cardiotonic AWD 122-14 are described. Thermic transformations of some polymorphic forms into the alpha-form was proved by thermogravimetric analysis and powder diffraction pattern. In dissolution behaviour no significant differences were found between the crystalline modifications but with regard to galenic processing compact alpha-, gamma- and epsilon-forms show advantages.
Hagen
V
V
Forschungsinstitut für Molekulare Pharmakologie, Berlin.
Reck
G
G
Dathe
M
M
Jänsch
H J
HJ
Feist
M
M
D002316:Cardiotonic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D009025:Morpholines / Q000138:chemical synthesis* / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D014961:X-Ray Diffraction
D002316:Cardiotonic Agents; D009025:Morpholines; D011725:Pyridines; C077469:3-cyano-2-morpholino-5-(pyrid-4-yl)pyridine
Potentielle Kardiotonika. 15. Mitteilung: Kristallmodifikationen von 3-Cyan-2-morpholino-5-(pyrid-4-yl)pyridin (AWD 122-14).