Aminoglycoside-modifying enzymes in clinical isolates harboring extended-spectrum beta-lactamases.
The aminoglycoside-modifying enzymes present in the first 120 clinical isolates harboring extended-spectrum beta-lactamases isolated in Spain were studied. Most of these isolates (84%) were gentamicin resistant. The enzymes most frequently associated and cotransferred with SHV-2 or TEM-type beta-lactamases were AAC(3)V, APH(3"), and APH(3')I.
Fernandez-Rodriguez
A
A
Servicio de Microbiología, Hospital Clínico de San Carlos, Madrid, Spain.
Canton
R
R
Perez-Diaz
J C
JC
Martinez-Beltran
J
J
Picazo
J J
JJ
Baquero
F
F
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D004352:Drug Resistance, Microbial / Q000502:physiology; D004755:Enterobacteriaceae / Q000201:enzymology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D001618:beta-Lactamases / Q000096:biosynthesis*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D001618:beta-Lactamases