[Total cholesterol, LDL-cholesterol and apoprotein B in umbilical cord blood: cross-sectional study].
The aim of the present study was to evaluate, in a large series of term newborns, the prevalence of hypercholesterolemia in cord blood, using as parameters, levels of plasma cholesterol, LDL-cholesterol and apo B higher than mean + 2 standard deviations, alone or in association. Data reported here represent the results of a transversal study. 1275 term newborns were studied. In everybody, in cord blood samples, at birth, cholesterol, triglycerides, HDL-cholesterol, apoprotein B and LDL-cholesterol have been assayed. In 3.13% of them (40 subjects), cholesterol levels > mean + 2 standard deviations were present. Moreover, only 6 subjects (0.47%) showed all three parameter levels higher than mean + 2 standard deviations, and 4 subjects (0.31%), in spite of normal cholesterol levels, presented high LDL-cholesterol and apo B levels. Integrated utilization of these parameters in the neonatal screening of familial hypercholesterolemia will have to be confirmed by follow-up studies.
Averna
M R
MR
Cattedra di Patologia Medica, Università degli Studi di Palermo.
Barbagallo
C M
CM
Di Paola
G
G
Labisi
M
M
Pinna
G
G
Marino
G
G
Dimita
U
U
Notarbartolo
A
A
D001055:Apolipoproteins B / Q000097:blood*; D002784:Cholesterol / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000453:epidemiology; D007231:Infant, Newborn; D007558:Italy / Q000453:epidemiology; D008297:Male; D015997:Neonatal Screening
D001055:Apolipoproteins B; D008078:Cholesterol, LDL; D002784:Cholesterol
Colesterolo totale, LDL-colesterolo ed apoproteina B nel cordone ombelicale: studio trasversale.