Systemic absorption of ocular cyclopentolate in children.
Cyclopentolate plasma levels were quantitated and heart rate and pupil size were monitored after ocular application of the drug to juveniles. In all, 12 children were given one 35-microliters eyedrop of either 1% cyclopentolate (n = 6) or placebo (n = 6) in randomized order in the lower cul-de-sac of one eye. A sensitive radioreceptor assay was used to determine the systemic drug absorption. With the exception of one child, detectable cyclopentolate concentrations were seen in plasma at as early as 3 min after the ocular drug application. There was a marked interindividual variation in peak plasma cyclopentolate concentrations ranging from undetectably low to 5.8 ng/ml (median, 2.9 ng/ml). In some children a second drug concentration peak was detected. Cyclopentolate increased the pupillary diameter from 4.8 +/- 1 mm before drug application to 8 +/- 0.9 mm at 30 min after administration, but the children's heart rate did not alter.
Lahdes
K
K
Department of Ophthalmology, University of Turku, Finland.
Huupponen
R
R
Kaila
T
T
Ali-Melkkilä
T
T
Salminen
L
L
Saari
M
M
D000042:Absorption; D002648:Child; D003519:Cyclopentolate / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005123:Eye / Q000378:metabolism*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D009883:Ophthalmic Solutions; D011680:Pupil / Q000187:drug effects; D011869:Radioligand Assay; D011897:Random Allocation; D013285:Strabismus / Q000601:surgery
D009883:Ophthalmic Solutions; D003519:Cyclopentolate