[Parameters of organ-specific and non-specific autoimmunity in patients with Basedow's disease and Basedow's ophthalmopathy. Changes induced by IVIG treatment].
The aim of this study was to evaluate the variations of thyroid autoantibodies titre in a group of 15 patients affected with "Graves' disease" (G. D.) during the treatment with antithyroid drug (ATD) and "high dose intravenous immunoglobulin" (IVIG) for "Graves' ophthalmopathy". Before the starting of treatment thyroglobulin antibodies (TgAb) were positive in 10/15 patients, microsomal antibodies (MAb) were positive in 13/15 patients and TRAb were positive in 5/9 patients. At the end of treatment TgAb titre was decreased or negative in 7/10 patients, MAb titre was decreased or negative in 7/13 patients, TRAb titre was diminished or negativized in 5/5 patients. Anti-nuclear antibodies (ANA) and anti-smooth muscle antibodies (ASMA) were positive in 3/15 and 3/15 patients before the treatment and in all these we observed a reduction or negativization of circulating titre during IVIG treatment. Anti-extractable nuclear antigen (ENA)m anti-mitochondrial antibodies (AMA) and rheumatoid factors were negative in all the patients. Also in the 3 patients not treated with ATD we have observed a reduction or a negativization of circulating thyroid autoantibodies. In conclusion these data suggest that the reduction of thyroid and non organ specific autoantibodies might be due to a stable immunosuppressive action of IVIG treatment in patients with Graves' disease.
Antonelli
A
A
Istituto di Clinica Medica II, Università degli Studi di Pisa.
Melosi
A
A
Saracino
A
A
Alberti
B
B
Agostini
S
S
Neri
S
S
Gambuzza
C
C
Biondi
L
L
Baschieri
L
L
D001323:Autoantibodies / Q000097:blood*; D006111:Graves Disease / Q000276:immunology* / Q000628:therapy*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008861:Microsomes / Q000276:immunology; D009928:Organ Specificity / Q000276:immunology; D013961:Thyroid Gland / Q000276:immunology*
D001323:Autoantibodies; D016756:Immunoglobulins, Intravenous
Indici di autoimmunità organospecifica e non in pazienti affetti da morbo di Basedow ed oftalmopatia basedowiana. Variazioni indotte dal trattamento con IVIG.