title: The cognitive principle challenges clonal selection.
abstract: Here, Irun Cohen argues that the clonal selection paradigm is no longer a convenient paradigm for organizing thinking about the immune system. He contends that most immunologists now investigate questions for which the clonal selection paradigm makes no provision and that one of its major tenets is contradicted by the prevalence of natural autoimmunity. Instead, he proposes a cognitive paradigm.
authors: Dept of Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
authors: I R
authors: IR
authors: Cohen
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis / Q000502:physiology; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000145:classification / Q000276:immunology; D015551:Autoimmunity; D016175:B-Lymphocyte Subsets / Q000276:immunology; D002999:Clone Cells / Q000276:immunology*; D007108:Immune Tolerance; D007257:Information Theory; D008954:Models, Biological; D008968:Molecular Conformation; D012641:Selection, Genetic; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D001323:Autoantibodies; D001324:Autoantigens