title: [Reactive histiocytosis during initial remission induction therapy for acute myeloblastic leukemia].
abstract: Six of 14 patients with acute myeloblastic leukemia (AML) complicated reactive histiocytosis during initial remission induction therapy. All six patients had a high fever without signs of infection during initial chemotherapy, and periods of myelosuppression were prolonged. Histiocytes with a mature appearance, some of which phagocyted erythrocytes, thrombocytes or neutrophils, increased in the bone marrow. All of 3 patients tested showed high serum levels of ferritin. Two of 3 patients treated with 125 mg/day methylprednisolone achieved complete remission. In the remaining 3 patients, one patient achieved complete remission, but the others died of fungal pneumonia or sepsis. Thus, reactive histiocytosis is one of the severe complications in patients with AML undergoing chemotherapy.
authors: Second Department of Internal Medicine, Kumamoto University Medical School.
authors: T
authors: T
authors: Okubo
authors: N
authors: N
authors: Asou
authors: H
authors: H
authors: Suzushima
authors: S
authors: S
authors: Matsumi
authors: M
authors: M
authors: Uchiba
authors: Y
authors: Y
authors: Okuno
authors: S
authors: S
authors: Nishimura
authors: K
authors: K
authors: Takatsuki
authors: F
authors: F
authors: Kawano
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D015616:Histiocytosis, Non-Langerhans-Cell / Q000209:etiology*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D012074:Remission Induction