Error rates in cefoperazone and cefoperazone-sulbactam disk tests with Enterobacteriaceae and Pseudomonas aeruginosa.
In a collaborative study involving five medical centers, 6% of 2,440 consecutive isolates of Enterobacteriaceae were resistant to cefoperazone; resistance to cefoperazone was reduced to < 1% by the addition of sulbactam. Susceptibility to cefoperazone and cefoperazone-sulbactam was accurately predicted by disk diffusion tests. Resistance to cefoperazone, however, was not as reliably detected by disk tests and results of dilution tests were not always consistent. The prevalence of resistance to cefoperazone and/or the ability to detect resistance had a significant influence on very major error rates for individual laboratories.
Hardy
D J
DJ
Department of Microbiology and Immunology, University of Rochester Medical Center, New York 14642-8710.
Barry
A L
AL
Fuchs
P C
PC
Gerlach
E H
EH
McLaughlin
J C
JC
Pfaller
M A
MA
D000362:Agar; D002438:Cefoperazone / Q000494:pharmacology*; D003470:Culture Media; D004338:Drug Combinations; D004352:Drug Resistance, Microbial; D004755:Enterobacteriaceae / Q000187:drug effects*; D005189:False Positive Reactions; D008826:Microbial Sensitivity Tests / Q000379:methods / Q000592:standards*; D010403:Penicillin Resistance; D011237:Predictive Value of Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013407:Sulbactam / Q000494:pharmacology*
D003470:Culture Media; D004338:Drug Combinations; D002438:Cefoperazone; D000362:Agar; D013407:Sulbactam