Cochinmicins, novel and potent cyclodepsipeptide endothelin antagonists from a Microbispora sp. I. Production, isolation, and characterization.
Cochinmicins I, II, III are novel peptolides produced in submerged-fermentation cultures of Microbispora sp. ATCC 55140. These closely related compounds are separated by HPLC and are novel competitive endothelin antagonists. Cochinmicins II and III are stereoisomeric to each other. Cochinmicin I is the deschloro analog of cochinmicin III.
Lam
Y K
YK
Merck Research Laboratories, Rahway, New Jersey 07065.
Williams
D L
DL
Sigmund
J M
JM
Sanchez
M
M
Genilloud
O
O
Kong
Y L
YL
Stevens-Miles
S
S
Huang
L
L
Garrity
G M
GM
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001011:Aorta / Q000378:metabolism; D001419:Bacteria / Q000187:drug effects; D001667:Binding, Competitive; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D016232:Endothelins / Q000037:antagonists & inhibitors*; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D006624:Hippocampus / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D008848:Micromonosporaceae / Q000254:growth & development / Q000378:metabolism*; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; D016232:Endothelins; D010456:Peptides, Cyclic; C078833:cochinmicin I; C078835:cochinmicin II; C078836:cochinmicin III