title: Temporomandibular joint dysfunction. Connective tissue variations in skin biopsy and mitral valve function.
abstract: Ten women with temporomandibular joint dysfunction and general joint hypermobility (score, 4 to 8) and 10 symptom-free female volunteers without systemic laxity (score, 0 to 2) were selected for the study. A biopsy of connective tissue from arm skin found that the total collagen concentrations were lower and the proteoglycan values were higher in the hypermobile TMJ patients than in the control subjects. The mitral region of the heart was inspected by echocardiography. Eight patients and four controls had slightly abnormal echocardiographic findings. Two patients fulfilled the criteria for mitral valve prolapse. The patients had significantly more musculoskeletal complaints than did the controls. The study suggests an association between joint hypermobility, abnormal skin connective tissue composition, mitral valve malfunction, and musculoskeletal disorders in young women with TMJ dysfunction, especially internal derangement.
authors: Department of Stomatognathic Physiology, Faculty of Odontology, University of Göteborg, Sweden.
authors: L
authors: L
authors: Westling
authors: S
authors: S
authors: Holm
authors: I
authors: I
authors: Wallentin
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003094:Collagen / Q000032:analysis; D003240:Connective Tissue Diseases / Q000503:physiopathology*; D004452:Echocardiography; D005260:Female; D006801:Humans; D004204:Joint Dislocations / Q000150:complications*; D007593:Joint Instability / Q000150:complications*; D008943:Mitral Valve / Q000503:physiopathology*; D008945:Mitral Valve Prolapse / Q000150:complications; D011509:Proteoglycans / Q000032:analysis; D016059:Range of Motion, Articular; D012867:Skin / Q000737:chemistry; D011795:Surveys and Questionnaires; D013705:Temporomandibular Joint Disorders / Q000150:complications*
chemical_list: D011509:Proteoglycans; D003094:Collagen