[Activity of glucose-6-phosphate dehydrogenase in erythrocytes in patients with atopic asthma and allergic rhinitis].
A significant decrease of erythrocyte G-6-P dehydrogenase activity in patients with atopic asthma and allergic rhinitis was observed. In order to define the cause of this phenomenon the enzyme was isolated from the cells. The kinetic and molecular properties of the erythrocyte G-6-P dehydrogenase were studied. A change in the Michaelis constant for G-6-P dehydrogenase was seen in erythrocytes of both patient groups. The thermoresistance at 45 C was reduced significantly. These modified properties can imply a change in the dehydrogenase molecule, this is seen more significantly in the group with allergic rhinitis.
Tyran
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Zakładu Biochemii AM we Wrocławiu.
Wrzyszcz
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D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000201:enzymology*; D004912:Erythrocytes / Q000201:enzymology*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D006801:Humans; D006255:Rhinitis, Allergic, Seasonal / Q000201:enzymology*
D005954:Glucosephosphate Dehydrogenase
Aktywność dehydrogenazy glukozo-6-fosforanowej krwinek czerwonych u chorych na atopowa astme oskrzelowa i katar sienny.