Peroxidative stress effects on calpain activity in brain of young and adult rats.
Three hours after administration of the pro-oxidant 2-cyclohexen-1-one, calpain activity was significantly reduced in the brain of young rats, but not in the brain of adult rats, and cathepsin D activity remained unchanged. Addition of isovalerylcarnitine to the incubation medium increased calpain activity 5-7-fold, counteracting the effect of the pro-oxidant.
Benuck
M
M
N.S. Kline Institute for Psychiatric Research, Center for Neurochemistry, Orangeburg, NY 10962.
Banay-Schwartz
M
M
Ramacci
M T
MT
Lajtha
A
A
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002154:Calpain / Q000378:metabolism*; D002331:Carnitine / Q000031:analogs & derivatives / Q000494:pharmacology; D002402:Cathepsin D / Q000378:metabolism; D003512:Cyclohexanones; D051381:Rats; D017207:Rats, Sprague-Dawley; D013312:Stress, Physiological / Q000139:chemically induced / Q000378:metabolism*
D003512:Cyclohexanones; C027333:3-methylbutyrylcarnitine; C028215:2-cyclohexen-1-one; D002154:Calpain; D002402:Cathepsin D; D002331:Carnitine