[A new marker of aggressivity of breast cancers: loss of heterozygote on chromosome 7q].
The etiology of breast cancer is a complex interplay of various factors, including genetic alterations. A number of studies have been made to identify and characterize mutations that frequently occur during breast tumorigenesis. In this paper, we have described a new deletion, located on the long arm of chromosome 7. Patients whose tumor carried a deletion on chromosome 7q had a significantly shorter survival time. These findings identify the long arm of chromosome 7 as a candidate region for a putative tumor (or metastasis) suppressor gene.
Bièche
I
I
Laboratoire d'oncovirologie, centre René-Huguenin, St-Cloud, France.
Champème
M H
MH
Matifas
F
F
Hacène
K
K
Lidereau
R
R
D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000235:genetics*; D002872:Chromosome Deletion; D002897:Chromosomes, Human, Pair 7; D005260:Female; D016147:Genes, Tumor Suppressor / Q000235:genetics; D005819:Genetic Markers; D006579:Heterozygote; D006801:Humans; D011379:Prognosis
D014408:Biomarkers, Tumor; D005819:Genetic Markers
Un nouveau marqueur de l'agressivité des tumeurs du sein: les pertes d'hétérozygotie sur le chromosome 7q.