title: [Sulbactam-ampicillin in surgery. Our experience].
abstract: The bacterial infections constitute a serious problem for the surgeon: the choice of antibiotic drugs is really important and, as often as possible, should be guided by antibiotic sensitivity tests. In this study we used sulbactam-ampicillin (Unasyn) who is an antibiotic combination between sulbactam, inhibitor of beta lactam and ampicillin. The preliminary results were as follows: Unasyn was administered to 21 hospitalized selected patients, 16 women and 5 man, who had clinical signs of intraabdominal infection, wound infection and subphrenic abscess after digestive surgery. In these patients were isolated the following organisms: Staphylococcus epidermidis (8), Staphylococcus aureus (11), serratia (1), streptococcus (3), E. coli (3). The daily dosage of Unasyn was 3-12 g/die administered in three to four divided doses, and was determined by the severity of infection, the antibiotic susceptibility of the causative organism(s) and the condition of the patient. Each dose was given by slow i.v. infusion in 15-30 minutes. Our success rate was 100%, and neither systemic nor local side effects were recorded.
authors: Istituto di Chirurgia Generale ed Oncologia Chirurgica, Universitä delgi Studi di Milano.
authors: R
authors: R
authors: Germiniani
authors: S
authors: S
authors: Casiraghi
authors: M
authors: M
authors: Pace
authors: P
authors: P
authors: Caspani
authors: E
authors: E
authors: Trabucchi
mesh_terms: D000328:Adult; D000368:Aged; D000667:Ampicillin / Q000008:administration & dosage / Q000627:therapeutic use*; D003428:Cross Infection / Q000188:drug therapy*; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D013407:Sulbactam / Q000008:administration & dosage / Q000627:therapeutic use*; D013514:Surgical Procedures, Operative; D013997:Time Factors
chemical_list: C035444:sultamicillin; D000667:Ampicillin; D013407:Sulbactam
vernacular_title: Sulbactam-ampicillina in chirurgia. La nostra esperienza.