[Application of transgenic model in renal research].
In the present report, we have used transgenic models to analyze the role of growth factors in the development of glomerulosclerosis. All peptides inducing a growth response do not lead to glomerulosclerosis, however, several transgenic models including growth hormone, transforming growth factor-a or SV 40T antigen developed progressive glomerulosclerosis, which was associated with glomerular hypertrophy. Evidence obtained from these transgenic models suggests that glomerulosclerosis may be related to a dysregulation of glomerular cell growth and a synthesis of extracellular matrix components by resident glomerular cells.
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Department of Geriatric Medicine, Faculty of Medicine, Kyoto University.
D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000502:physiology*; D002455:Cell Division; D004195:Disease Models, Animal; D005109:Extracellular Matrix / Q000378:metabolism; D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology* / Q000473:pathology; D006133:Growth Substances / Q000502:physiology*; D006984:Hypertrophy; D007678:Kidney Glomerulus / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics*
D000952:Antigens, Polyomavirus Transforming; D006133:Growth Substances