Effect of endothelin on somatosensory evoked potentials in rats.
The effects of endothelin 1 (ET-1; 300 pmol/rat intracarotid) on somatosensory evoked potential were investigated in rats. ET-1 led to an amplitude reduction, peak latency prolongations and waveform disturbances. There was a large interindividual variability. The late cortical components were more affected than the earlier potentials at a thalamic or cortical level. ET-1-induced SEP changes developed quickly after the drug injection and persisted for at least 30 min. It is assumed that the observed effects probably reflect the occurrence of a progressively developing ischemia subsequent to ET-1 administration. Moreover, the pattern of ET-1-induced changes suggests a greater sensitivity of the synaptic transmission to the ischemic influence than the axonal conduction.
Todorova
A
A
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Higher Medical Institute, Sofia, Bulgaria.
Boyagieva
M
M
Yosifov
T
T
D000818:Animals; D004569:Electroencephalography / Q000187:drug effects / Q000295:instrumentation; D016232:Endothelins / Q000494:pharmacology*; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D007269:Injections, Intra-Arterial; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation; D013003:Somatosensory Cortex / Q000187:drug effects
D016232:Endothelins