Multiple sclerosis patients express increased levels of beta-nerve growth factor in cerebrospinal fluid.
We describe the measurement of beta-nerve growth factor (NGF) content in cerebrospinal fluid (CSF) from multiple sclerosis (MS) patients compared with CSF from age-matched normal subjects using a specific sandwich immunoassay (ELISA). During acute attacks patients exhibit a significant increase of NGF content compared to controls. In contrast during remission the mean NGF levels in CSF markedly decrease. These results strongly indicate that increased NGF production in CSF is a characteristic feature of the MS inflammatory response.
Laudiero
L B
LB
Institute of Neurobiology, CNR, Rome, Italy.
Aloe
L
L
Levi-Montalcini
R
R
Buttinelli
C
C
Schilter
D
D
Gillessen
S
S
Otten
U
U
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid*; D009414:Nerve Growth Factors / Q000134:cerebrospinal fluid*; D012016:Reference Values
D009414:Nerve Growth Factors