title: Patterns of spatiotemporal organization in an "ambiquitous" enzyme model.
abstract: Many enzymes in pathways such as glycolysis associate reversibly with cellular substructures. The spatiotemporal behavior of a "limit-cycle" oscillation model is studied under the condition that the "ambiquitous" oscillophor, phosphofructokinase, is partitioned between "bulk-phase" and "bound" forms in a heterogeneous system. Computer simulation demonstrates the occurrence of sustained, wave-like spatiotemporal patterns of chemical concentration in the bulk medium. Kinetic dissimilarity among the localized populations of bound enzyme leads to a "polarity" effect in the wave phenomenon. It is suggested that a key physiological role of the limit-cycle regime is to engender a rapid, site-to-site, signal-transmission modality in large eukaryotic (e.g., mammalian) cells.
authors: Department of Biological Sciences, University of New Orleans, LA 70148.
authors: P
authors: P
authors: Marmillot
authors: J F
authors: JF
authors: Hervagault
authors: G R
authors: GR
authors: Welch
mesh_terms: D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D002451:Cell Compartmentation; D003198:Computer Simulation; D003599:Cytoskeleton / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D004058:Diffusion; D006019:Glycolysis; D008322:Mammals; D008954:Models, Biological; D010507:Periodicity; D010732:Phosphofructokinase-1 / Q000378:metabolism*
chemical_list: D000227:Adenine Nucleotides; D010732:Phosphofructokinase-1