Improvement of clinical and MRI findings in a boy with adrenoleukodystrophy by dietary erucic acid therapy.
A 5-year-old boy with adrenoleukodystrophy, with clinical symptoms of visual, mental and motor disturbances which progressed rapidly, was treated with Lorenzo's oil consisting 1 volume of glyceryl trierucate and 4 volumes of glyceryl trioleate. Five months after initiation of this therapy, ability to swallow was enhanced and T2-weighted magnetic resonance imaging of the brain revealed regression of high intensity area of the parieto-occipital white matter.
Maeda
K
K
Department of Pediatrics, Shizuoka Saiseikai General Hospital, Japan.
Suzuki
Y
Y
Yajima
S
S
Asano
J
J
Yamaguchi
S
S
Matsumoto
N
N
Borel
J
J
Moser
H W
HW
Orii
T
T
D000326:Adrenoleukodystrophy / Q000178:diet therapy* / Q000473:pathology / Q000503:physiopathology; D001921:Brain / Q000473:pathology; D002675:Child, Preschool; D004042:Dietary Fats, Unsaturated / Q000627:therapeutic use*; D004338:Drug Combinations; D004883:Erucic Acids / Q000627:therapeutic use*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D014304:Triolein / Q000627:therapeutic use*
D004042:Dietary Fats, Unsaturated; D004338:Drug Combinations; D004883:Erucic Acids; C079420:Lorenzo's oil; D014304:Triolein