title: Improved production of pentostatin and identification of fermentation cometabolites.
abstract: A practical process is described for the large-scale isolation of pentostatin, an adenosine deaminase inhibitor used clinically for the treatment of interferon-refractory hairy cell leukemia. The identities of minor components in the fermentation beer, including 2'-deoxyguanosine, are also reported.
authors: Parke-Davis Pharmaceutical Research Division, Warner-Lambert Co., Ann Arbor, Michigan 48105.
authors: H D
authors: HD
authors: Showalter
authors: R H
authors: RH
authors: Bunge
authors: J C
authors: JC
authors: French
authors: T R
authors: TR
authors: Hurley
authors: R L
authors: RL
authors: Leeds
authors: B
authors: B
authors: Leja
authors: P D
authors: PD
authors: McDonnell
authors: C R
authors: CR
authors: Edmunds
mesh_terms: D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D003849:Deoxyguanosine / Q000737:chemistry; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D015649:Pentostatin / Q000737:chemistry* / Q000302:isolation & purification*; D013303:Streptomyces antibioticus / Q000737:chemistry*
chemical_list: D015649:Pentostatin; D003849:Deoxyguanosine