[Effect of plasmapheresis on the course of experimental tuberculosis and the tolerance of chemotherapy by patients with renal tuberculosis].
A plasmapheresis (PA) model was developed to be used in chronic rabbit experiments. Test results obtained in 96 generalized tuberculosis animals demonstrated a more benign tuberculosis process in animals subjected to plasmapheresis, which was confirmed by parameters of the coefficients of mass and indices of animals' organ affecting, findings of the cation-lysosomal test and peptide molecules content in the peripheral blood. Rabbit studies involving registration of bromsulphalein half-life, hepatic blood flow and relative parenchymatous clearing showed that the isoniazide and rifampicin action significantly decreased under the PA influence. Studies in a hospital accommodating 90 patients with different renal tuberculosis forms and poor tuberculostatic tolerance showed that PA promoted restoration of tolerance to specific preparations and renal function improvement. PA was found to be practicable and safe method which relieves side effects of antituberculous preparations and contributes to tuberculosis treatment efficiency.
Bispen
A V
AV
Aleksandrova
A E
AE
Vakhmistrova
T I
TI
Vinogradova
T I
TI
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000517:prevention & control; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D004361:Drug Tolerance; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage* / Q000633:toxicity; D009163:Mycobacterium bovis; D010956:Plasmapheresis; D011817:Rabbits; D012293:Rifampin / Q000008:administration & dosage* / Q000633:toxicity; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000628:therapy*; D014398:Tuberculosis, Renal / Q000188:drug therapy / Q000628:therapy*
D007538:Isoniazid; D012293:Rifampin
Vliianie plazmafereza na techenie éksperimental'nogo tuberkuleza i perenosimost' khimioterapii ftiziourologicheskimi bol'nymi.