[Diagnostic value of autoantibodies against microsomal thyroid peroxidase (anti-TPO)].
With the identification of thyroid peroxidase (TPO) as the main antigen of the thyroid microsomal fraction, the development of a sensitive and specific assay for detection of these antibodies became possible. The diagnostic value of the anti-TPO assay was evaluated in patients with different types of thyroid disease and in controls. 65% of patients with thyroiditis had elevated anti-TPO values. The frequency of elevated anti-TPO levels in patients with active autoimmune thyroiditis was 90% (clinical diagnosis Hashimoto thyroiditis) compared to 64% in patients with overt hyperthyroidism (clinical diagnosis Graves' disease). None of the controls or the patient with non-thyroidal illness showed elevated anti-TPO levels.
Engler
H
H
Institut für klinische Chemie und Hämatologie des Kantons St. Gallen.
Riesen
W F
WF
Keller
B
B
D001323:Autoantibodies / Q000302:isolation & purification*; D006111:Graves Disease / Q000276:immunology*; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology*; D008861:Microsomes / Q000276:immunology; D011237:Predictive Value of Tests; D013967:Thyroiditis, Autoimmune / Q000276:immunology*
D001323:Autoantibodies; D007453:Iodide Peroxidase
Diagnostische Validität von Autoantikörpern gegen die mikrosomale Schilddrüsenperoxidase (anti-TPO).