[Changes in the mechanism of action of insulin on fatty tissue accumulations in lipomas, Madelung's lipomatosis and liposarcoma].
In this paper, the preliminary results regarding the alterations of the biological action mechanism of insulin in several types of pathological accumulations of fat, i.e. lipomas, Madelung's Lipomatosis and liposarcoma, are presented. The results indicate significant alterations both at the insulin receptor and post-receptor levels, with reduced biological activity of this hormone, which could have and inductive role in the pathogenesis of such entities.
Carranza
M C
MC
Departamento de Bioquímica, Facultad de Medicina, Universidad Complutense, Madrid.
Simón
M A
MA
Torres
A
A
Romero
B
B
Calle
C
C
D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000328:Adult; D005260:Female; D006801:Humans; D007328:Insulin / Q000493:pharmacokinetics / Q000494:pharmacology*; D008067:Lipoma / Q000209:etiology / Q000378:metabolism*; D008069:Lipomatosis, Multiple Symmetrical / Q000209:etiology / Q000378:metabolism*; D008080:Liposarcoma / Q000209:etiology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011972:Receptor, Insulin / Q000187:drug effects / Q000378:metabolism; D012186:Retroperitoneal Neoplasms / Q000209:etiology / Q000378:metabolism*; D012878:Skin Neoplasms / Q000209:etiology / Q000378:metabolism*
D007328:Insulin; D011972:Receptor, Insulin
Alteraciones en el mecanismo de acción de la insulina en los acúmulos de tejido adiposo de lipomas, lipomatosis de Madelung y liposarcoma.