Zinc deficiency in the rat alters the lipid composition of the erythrocyte membrane Triton shell.
The effect of dietary zinc deficiency on the lipid composition of the erythrocyte membrane Triton shell was determined. Weanling male Wistar rats were fed an egg white-based diet containing < 1.0 mg Zn/kg diet ad libitum. Control rats were either pair-fed or ad libitum-fed the basal diet supplemented with 100 mg Zn/kg diet. A Zn refed group was fed the -Zn diet until day 18 and then pair-fed the +Zn diet until day 21. Dietary Zn deficiency caused an increased cholesterol/phospholipid ratio in Triton shells compared to those from pair-fed controls. Zn deficiency caused a decreased double bond index of fatty acids in phosphatidylinositol (PI) and phosphatidylcholine (PC); there was a decreased proportion of 18:2n-6 and 22:4n-6 in PC and 20:4n-6 in PI as compared to that found in pair-fed controls. All glycerophospholipids that were retained in the shell had a lower double bond index and increased content of 16:0 and/or 18:0 relative to the phospholipid in the intact membrane.
Driscoll
E R
ER
Department of Nutritional Sciences, University of Guelph, Ontario, Canada.
Bettger
W J
WJ
D000818:Animals; D004032:Diet; D004910:Erythrocyte Membrane / Q000737:chemistry / Q000187:drug effects*; D005231:Fatty Acids, Unsaturated / Q000032:analysis; D008297:Male; D008563:Membrane Lipids / Q000737:chemistry*; D017830:Octoxynol; D010713:Phosphatidylcholines / Q000737:chemistry; D010714:Phosphatidylethanolamines / Q000737:chemistry; D010716:Phosphatidylinositols / Q000737:chemistry; D010718:Phosphatidylserines / Q000737:chemistry; D011092:Polyethylene Glycols / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D013109:Sphingomyelins / Q000737:chemistry; D014886:Weaning; D015032:Zinc / Q000172:deficiency* / Q000494:pharmacology
D005231:Fatty Acids, Unsaturated; D008563:Membrane Lipids; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010716:Phosphatidylinositols; D010718:Phosphatidylserines; D013109:Sphingomyelins; D011092:Polyethylene Glycols; D017830:Octoxynol; D015032:Zinc