title: [Pharmacokinetics of hypolipedemic agents. 9. The question of biliary excretion of the hypolipidemic agent ciprofibrate (1) (2-(4-(2,2-dichlorocyclopropyl)-phenoxy)-2-methylpropionic acid].
abstract: After oral administration of 200 mg Ciprofibrate (1) to 10 patients, who were cholecystectomated with subsequent T-drainage, 1 could be determined in the collected bile only as its 1-O-beta-acylglucuronide to a very small amount. Approximative calculations have shown that two days after a single dose, less than 0.5% of the administered dose of 1 is excreted on the biliary route. It is an unsolved problem if there is an increase of biliary excretion after multiple dose.
authors: Institut für Pharmazeutische Chemie, Johann Wolfgang Goethe-Universität Frankfurt am Main.
authors: H
authors: H
authors: Oelschläger
authors: D
authors: D
authors: Rothley
authors: D
authors: D
authors: Schröder
authors: S
authors: S
authors: Scherm
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001646:Bile / Q000378:metabolism*; D002994:Clofibrate / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D000960:Hypolipidemic Agents / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged
chemical_list: D000960:Hypolipidemic Agents; D002994:Clofibrate
vernacular_title: Zur Frage der biliären Ausscheidung des Lipidsenkers Ciprofibrat (1) (2-[4-(2,2-Dichlorcyclopropyl)-phenoxy]-2-methylpropionsäure).