Accumulation of cholesteryl ester in atherosclerotic lesions.
This article reviews aspects of the molecular pathology of cholesteryl ester accumulation in atherosclerotic lesions. 1. Transcytosis of lipoproteins through a cultured endothelial monolayer. 2. Effects of platelets and PGI2 on intercellular transport of endothelial cells. 3. Transformation of macrophages to foam cells. 4. Cholesteryl ester deposition in the extracellular space of atherosclerotic lesions. The development and use of novel monoclonal antibodies recognizing atherosclerotic lesions and peroxidized lipoproteins prepared from then are also discussed.
Takano
T
T
Department of Microbiology and Molecular Pathology, Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan.
D000818:Animals; D001161:Arteriosclerosis / Q000378:metabolism*; D002788:Cholesterol Esters / Q000378:metabolism*; D006801:Humans
D002788:Cholesterol Esters