title: Chromosome abnormalities in liposarcomas.
abstract: We performed a cytogenetic study of short-term cultures from fresh surgical specimens obtained from four patients with liposarcoma. Myxoid liposarcomas (cases 1-3) were associated with a specific translocation between chromosomes 12 and 16. Trisomy 8, a nonrandom secondary aberration in myxoid liposarcoma, was observed in the third case as the only additional change. Round cell liposarcoma (case 4) showed complex chromosomal aberrations affecting chromosomes 1, 2, 5, 6, 7, 13, 14, 17, 19, and 22. Neither band 12q13 nor 16p11 was visibly rearranged. Three subgroups of liposarcomas are proposed. The first group is characterized by t(12;16)(q13;p11), the second group by ring chromosomes, telomeric associations, and giant markers, and the last by complex numerical and structural aberrations.
authors: Department of Pathology, Fukuoka University School of Medicine, Japan.
authors: Y
authors: Y
authors: Ohjimi
authors: H
authors: H
authors: Iwasaki
authors: Y
authors: Y
authors: Kaneko
authors: M
authors: M
authors: Ishiguro
authors: A
authors: A
authors: Ohgami
authors: C
authors: C
authors: Fujita
authors: N
authors: N
authors: Shinohara
authors: K
authors: K
authors: Yoshitake
authors: M
authors: M
authors: Kikuchi
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D008080:Liposarcoma / Q000235:genetics* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D012983:Soft Tissue Neoplasms / Q000235:genetics / Q000648:ultrastructure; D014178:Translocation, Genetic; D014314:Trisomy