Acute lymphoblastic leukaemia in a child with cystic fibrosis.
The association of cystic fibrosis (CF) and acute lymphoblastic leukaemia (ALL) is extremely rare. Only three cases have been reported in the literature and all of them had a fatal outcome. In this paper we describe the case of a little girl who was diagnosed with CF (mild course) when she was five months old, and who presented at the age of five years with ALL (intermediate risk). Complete Remission (CR) was rapidly obtained with standard chemotherapy for ALL.; treatment was continued for two years without major complications and with no apparent influence on the course of CF. The patient remains alive and well and in continuous CR four years after discontinuing treatment, and six years after the diagnosis of ALL.
Rizzari
C
C
Dipartimento di Ematologia Pediatrica, Università di Milano, Ospedale San Gerardo, Monza, Italy.
Conter
V
V
Jankovic
M
M
D'Angelo
P
P
Masera
G
G
Costantini
D
D
Bettinelli
M E
ME
Giunta
A M
AM
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001215:Asparaginase / Q000008:administration & dosage; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D003550:Cystic Fibrosis / Q000150:complications* / Q000453:epidemiology; D003630:Daunorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D015122:Mercaptopurine / Q000008:administration & dosage; D008727:Methotrexate / Q000008:administration & dosage; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology / Q000532:radiotherapy; D011241:Prednisone / Q000008:administration & dosage; D012074:Remission Induction; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D015122:Mercaptopurine; D001215:Asparaginase; D011241:Prednisone; D008727:Methotrexate; D003630:Daunorubicin