Synthesis, structure and biological activity of 1,2,4-triazolo-1,3-thiazine derivatives.
A group of condensed triazole-thiazine derivatives (2a-i, 3b, 3j) was obtained in reaction of the corresponding 5-substituted 1,2,4-triazole-3-thiones (1a-j) with epichlorohydrin in alkaline medium. The structure of the compounds synthesized was confirmed by spectral and roentgenographic methods. Tuberculostatic and circulatory activities of the compounds were also studied.
Foks
H
H
Department of Organic Chemistry, Medical Academy of Gdańsk, Poland.
Rudnicka
W
W
Głowka
M
M
Kaliszan
R
R
Nasal
A
A
Damasiewicz
B
B
Radwańska
A
A
Petrusewicz
J
J
Trzeciak
H
H
Okopień
B
B
D000818:Animals; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002316:Cardiotonic Agents / Q000494:pharmacology; D002317:Cardiovascular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D013843:Thiazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000995:Antitubercular Agents; D002316:Cardiotonic Agents; D002317:Cardiovascular Agents; D013843:Thiazines; D014230:Triazoles