Human immunodeficiency virus (HIV) and HIV infected cells in saliva and salivary glands of a patient with systemic lupus erythematosus.
A young woman with systemic lupus erythematosus (SLE) was infected with human immunodeficiency virus 1 (HIV-1) and about 6 years later developed persistent bilateral parotid gland enlargement. It was unclear whether this represented salivary gland involvement as a component of her SLE (secondary Sjögren's syndrome) or the initial clinical manifestation of her HIV-1 infection. HIV proviral DNA was found in individual salivary glandular secretions and in whole saliva. Additionally, cells positive for HIV RNA were isolated from whole saliva. A parotid gland biopsy revealed infiltrating lymphocytes containing large amounts of HIV RNA.
Yeh
C K
CK
Clinical Investigations and Patient Care Branch, NIDR, National Institutes, of Health, Bethesda, MD 20892.
Fox
P C
PC
Goto
Y
Y
Austin
H A
HA
Brahim
J S
JS
Fox
C H
CH
D000328:Adult; D001706:Biopsy; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics; D005260:Female; D006678:HIV / Q000235:genetics / Q000302:isolation & purification*; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000382:microbiology / Q000473:pathology*; D008214:Lymphocytes / Q000737:chemistry; D010306:Parotid Gland / Q000382:microbiology / Q000473:pathology; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics; D012463:Saliva / Q000737:chemistry / Q000166:cytology* / Q000382:microbiology*; D012469:Salivary Glands / Q000737:chemistry / Q000382:microbiology* / Q000473:pathology*
D004279:DNA, Viral; D012367:RNA, Viral