title: The effect of indomethacin, diclofenac and flurbiprofen on the maintenance of mydriasis during extracapsular cataract extraction.
abstract: Surgically induced miosis (SIM) frequently occurs during extracapsular cataract extraction (ECCE). A randomized clinical trial was performed to evaluate the effect of 3 nonsteroidal antiinflammatory drugs Indomethacin 1%, Diclofenac 0.1% and Flurbiprofen 0.03%, administered topically before ECCE, on the maintenance of mydriasis during surgery. The patients were grouped based on the type of NSAID given preoperatively in addition to the standard mydriatic agents: 46 patients in group A (Indomethacin), 40 patients in B (Diclofenac), 44 patients in C (Flurbiprofen) and 34 patients formed control group D (no NSAID was instilled). Horizontal pupillary diameter measurements were taken, using a caliper, immediately prior to surgery (step 0), after capsulotomy (step I), after expression of the lens nucleus (step II) and after irrigation-aspiration of the cortical remnants (step III). Differences in pupillary diameter between step 0 and the different surgical steps were used as indices of pupillary constrictions observed in the 4 groups. A significantly less pupillary constriction was found in groups A and C than in D between steps 0 and II (p = 0.01) and in groups A and C than in B and D between steps 0 and III (p = 0.001). Our results show that Indomethacin 1% and Flurbiprofen 0.03%, compared to Diclofenac 0.1% and no NSAID regime, are significantly more effective in maintaining mydriasis during cataract surgery.
authors: University Eye Clinic of Ioannina, Greece.
authors: K
authors: K
authors: Psilas
authors: C
authors: C
authors: Kalogeropoulos
authors: E
authors: E
authors: Loucatzicos
authors: I
authors: I
authors: Asproudis
authors: G
authors: G
authors: Petroutsos
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002387:Cataract Extraction / Q000009:adverse effects*; D004008:Diclofenac / Q000008:administration & dosage; D005480:Flurbiprofen / Q000008:administration & dosage; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage; D007431:Intraoperative Complications / Q000209:etiology / Q000517:prevention & control*; D007903:Lens Capsule, Crystalline / Q000601:surgery*; D008875:Middle Aged; D015877:Miosis / Q000209:etiology / Q000517:prevention & control*; D009883:Ophthalmic Solutions; D011292:Premedication; D011680:Pupil / Q000187:drug effects*; D016896:Treatment Outcome
chemical_list: D009883:Ophthalmic Solutions; D004008:Diclofenac; D005480:Flurbiprofen; D007213:Indomethacin