Potentially active hypoglycemic agents from N1-nicotinoyl-2-pyrazolin-5-one derivatives and their N1-(oxynicotinoyl) analogues.
Several ethyl 2,3-dioxohexanoate 2-arylhydrazone derivatives were obtained via coupling of the appropriate diazonium chlorides with ethyl butanoylacetate. Acetic acid-mediated cyclization of these products with N1-nicotinoyl and/or N1-(oxynicotinoyl)hydrazine derivatives gave a new series of 4-arylhydrazono-3-(n-propyl)-N1-nicotinoyl-2-pyrazolin-5-one s (Va-h) as well as their N1-(oxynicotinoyl) analogues (VIa-h). The structure of the prepared compounds was confirmed on the basis of elemental and spectral data. The hypoglycemic effect, antibacterial activity and toxicity of these agents were evaluated and discussed.
Girges
M M
MM
Chemistry Department, Mansoura, Faculty of Science, Mansoura University, Egypt.
Hanna
M A
MA
Rasala
D
D
Berghot
M
M
D000818:Animals; D001419:Bacteria / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism; D002855:Chromatography, Thin Layer; D005260:Female; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D009539:Nicotinic Acids / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D013056:Spectrophotometry, Ultraviolet
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D009539:Nicotinic Acids; D011720:Pyrazoles