[The assessment of liver microsomal oxidative capacity via caffeine and antipyrine elimination in patients with chronic active hepatitis: preliminary results].
The hepatic metabolism of drugs in patients with chronic active hepatitis has been studied in a few occasions, finding discordant results. In our preliminary study we pretend to appraise the microsomal oxidative hepatic metabolism in 10 chronic active hepatitis HBs Ag(+) outpatients without clinical symptoms. The concentrations of both substances were measured in saliva and the caffeine and antipyrine tests of these patients were compared to control group. The difference found in the caffeine and antipyrine elimination, between the chronic active hepatitis group and the control group, have been low, without statistics significance (p > 0.1). Although, the results are preliminaries and is necessary to follow this study in many patients, probably the caffeine and antipyrine elimination are not decreased in the chronic active hepatitis without clinical symptoms. In these patients, the microsomal oxidative hepatic metabolism is not altered.
Soto Alvarez
J
J
Unidad de Farmacología Clínica, Hospital Santa Cruz, Liencres, Cantabria.
Alsar Ortiz
M J
MJ
D000328:Adult; D000983:Antipyrine / Q000493:pharmacokinetics; D002110:Caffeine / Q000493:pharmacokinetics; D005260:Female; D006521:Hepatitis, Chronic / Q000175:diagnosis / Q000201:enzymology*; D006801:Humans; D008111:Liver Function Tests / Q000379:methods; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D008875:Middle Aged; D010084:Oxidation-Reduction; D015203:Reproducibility of Results
D002110:Caffeine; D000983:Antipyrine
Valoración de la capacidad microsomal oxidativa hepática mediante la eliminación de cafeína y antipirina en pacientes con hepatitis crónica activa: resultados preliminares.