Effects of dietary protein on eicosanoid production and on the activity of related enzymes in glomeruli and tubules.
Glomeruli obtained from rats fed a high-protein diet for 8 weeks produce increased amounts of eicosanoids due to greater activity of both PE-specific phospholipase A2 and cyclooxygenase. Eicosanoid synthesis in response to angiotensin II is also greater in glomeruli from rats fed a high-protein diet when compared to rats fed a low-protein diet. There was also increased synthesis of eicosanoids in medullary/papillary tubules but not in proximal cortical tubules of rats fed a high-protein diet. This appears to be due to increased activity of PC-specific phospholipase A2 and cyclooxygenase in medullary/papillary tubules.
Klahr
S
S
Renal Division, Washington University School of Medicine, St. Louis, Mo.
Morrissey
J
J
Yanagisawa
H
H
D000818:Animals; D004044:Dietary Proteins / Q000494:pharmacology*; D015777:Eicosanoids / Q000096:biosynthesis*; D066298:In Vitro Techniques; D007678:Kidney Glomerulus / Q000201:enzymology / Q000378:metabolism*; D007684:Kidney Tubules / Q000201:enzymology / Q000378:metabolism*; D010741:Phospholipases A / Q000378:metabolism*; D054467:Phospholipases A2; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D051381:Rats
D004044:Dietary Proteins; D015777:Eicosanoids; D011451:Prostaglandin-Endoperoxide Synthases; D010741:Phospholipases A; D054467:Phospholipases A2