[Antifoaming agent microembolism in patients undergoing extracorporeal circulation. Its frequency in post mortem material and its pathogenic potential in vitro].
Antifoam microembolisms in patients that undergo open heart surgery, represent a risk for postoperative complications. We decided to study its frequency in an autopsy population of patients who died after heart surgery. Forty-five patients were selected and histological sections from the kidneys were studied under light microscopy, scanning electron microscopy and X-ray microanalysis. Thirty-six cases (80%) showed microemboli in the glomerular capillaries lumens. There was a positive correlation between the number of particles found and the length of the surgery. Microemboli were composed of an amorphous fraction and a particulated one composed of silicon. In vitro experimentation demonstrated that the particles are capable to induce cell lysis in a dose related manner. They also are susceptible of been phagocitated by macrophages. We conclude that bubble oxygenator are capable to induce microembolisms in a high percentage of the cases studied. Components of the microemboli are cytotoxic. Therefore microembolisms could be participating in the morbidity of patients subjects to cardiopulmonary bypass.
Suchil Bernal
L
L
Departamento de Patología, Instituto Nacional de Cardiología, México.
Hernández Rodríguez
N
N
Hurtado
J
J
Orsornio Vargas
A R
AR
D000934:Antifoaming Agents / Q000009:adverse effects* / Q000032:analysis / Q000494:pharmacology; D001344:Autopsy; D004617:Embolism / Q000139:chemically induced*; D005112:Extracorporeal Circulation; D005188:False Negative Reactions; D005189:False Positive Reactions; D006801:Humans; D007678:Kidney Glomerulus / Q000737:chemistry; D016676:Macrophages, Alveolar / Q000187:drug effects; D012680:Sensitivity and Specificity
D000934:Antifoaming Agents
Microembolias de antiespumante en pacientes sometidos a circulación extracorpórea. Frecuencia en material post mortem y su potencial patógeno in vitro.