[Multicenter study of sodium alginate in the treatment of regurgitation in infants].
An open multicenter study was performed to assess the efficacy and safety of alginic acid in two different dosages in 76 pediatric patients with gastroesophageal reflux confirmed by pH monitoring. Among the 69 patients in whom endoscopy was carried out before treatment, 18 had erythematous esophagitis and 5 had erosive esophagitis. Irrespective of the dosage used, the frequency of regurgitation and vomiting decreased significantly (p < 0.00001 and p = 0.01, respectively). Clinical and biochemical tolerance were outstanding and no adverse effects were recorded. On the basis of these data, the recommended dosage is 1 to 2 ml/kg/day in divided doses after meals.
Le Luyer
B
B
Département de Pédiatrie, Centre Hospitalier, Le Havre.
Mougenot
J F
JF
Mashako
L
L
Chapoy
P
P
Olives
J P
JP
Morali
A
A
Chevallier
B
B
Ginies
J L
JL
Dupont
C
C
Dagorne
M
M
D000464:Alginates / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000536:Aluminum Hydroxide / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001639:Bicarbonates / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002675:Child, Preschool; D004338:Drug Combinations; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005602:France / Q000453:epidemiology; D005745:Gastric Acidity Determination; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012824:Silicic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D017693:Sodium Bicarbonate
D000464:Alginates; D001639:Bicarbonates; D004338:Drug Combinations; D012824:Silicic Acid; D000536:Aluminum Hydroxide; C007829:alginate, aluminium hydroxide, magnesium trisilicate, sodium bicarbonate drug combination; D017693:Sodium Bicarbonate
Etude clinique multicentrique de l'alginate de sodium dans le traitement des régurgitations du nourrisson.