[Effect of long-term hemodialysis on luliberin-induced lutropin secretion in patients with chronic renal failure].
The purpose of the work was to answer the question whether time of haemodialysis treatment affects the secretion of lutropin (LH) in patients with chronic renal failure. The study was carried out in 41 men with chronic renal failure and 15 healthy controls. There were three groups of hemodialyzed patients. The first one comprised 17 patients dialyzed up to 50 months, the second one 14 patients treated during 51-100 months and the third one 10 patients hemodialyzed for more than 100 months. In all these subjects the test of stimulation with luliberin (LH-RH) was done. Significantly higher serum levels of LH were found in patients as compared to controls. No significant alterations in LH levels were observed in the groups of patients. After administration of LH-RH the reactivity of LH secretion was significantly lower in patients dialyzed longer than 50 months then in men dialyzed shorter and in controls. These facts suggest an influence of long-term dialysis treatment on the secretion of LH in men with chronic renal failure.
Starzyk
J
J
Oddział Nefrologii Wojewódzkiego Szpitala Zespolonego, Kielcach.
Grzeszczak
W
W
D000328:Adult; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology / Q000628:therapy*; D007986:Luteinizing Hormone / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000378:metabolism*; D006435:Renal Dialysis; D013268:Stimulation, Chemical; D013997:Time Factors
D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone
Wpływ wieloletniej hemodializoterapii na wydzielanie lutropiny indukowane luliberyna u chorych z przewlekła niewydolnościa nerek.