[The use of 6-flavor Rehmannia decoction with additives in the prevention of ototoxic deafness induced by gentamicin in guinea pigs].
The purpose of this study is to discuss the effects of the Chinese medicine six-flavor Rehmannia Decoction with additives on preventing deafness induced by gentamicin (GM) in guinea pig by means of testing the thresholds of Preyer's reflex (PR) cochlear microphonic potential (CM), action potential of the auditory nerve (N1) and scanning electron microscope of inner ear (SEM). The results showed that the medicine is effective in reducing the ototoxic effect of GM on inner ear.
Zhuang
J
J
Shanghai College of Traditional Chinese Medicine.
Zhang
M
M
Zeng
Z
Z
Xu
F
F
Han
T
T
Hu
S
S
Sun
Y
Y
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003055:Cochlear Microphonic Potentials / Q000187:drug effects; D003638:Deafness / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005839:Gentamicins; D006168:Guinea Pigs; D008297:Male; D009925:Organ of Corti / Q000648:ultrastructure; D012022:Reflex, Acoustic / Q000187:drug effects; D014722:Vestibule, Labyrinth / Q000648:ultrastructure; D000159:Vestibulocochlear Nerve / Q000187:drug effects
D004365:Drugs, Chinese Herbal; D005839:Gentamicins; C042579:Liuwei Dihuang Decoction