Antifungal activity of meridine, a natural product from the marine sponge Corticium sp.
Meridine [1], a polycyclic alkaloid derived from the marine sponge Corticium sp., was found to inhibit the growth of Candida albicans and Cryptococcus neoformans. Activity was also observed against Trichophyton mentagrophytes and Epidermophyton floccosum. Studies of the mechanism of action of this agent have shown an inhibition of nucleic acid biosynthesis.
McCarthy
P J
PJ
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Fort Pierce, Florida 34946.
Pitts
T P
TP
Gunawardana
G P
GP
Kelly-Borges
M
M
Pomponi
S A
SA
D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification*; D004271:DNA, Fungal / Q000096:biosynthesis; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011161:Porifera / Q000737:chemistry*
D000470:Alkaloids; D000935:Antifungal Agents; D004271:DNA, Fungal; C079196:meridine