title: [The effect of calcium antagonists on the cardiotoxic effects of isoprenaline in rats].
abstract: Rats were pretreated with either verapamil or nifedipine five minutes prior to isoprenaline injection in order to prevent the development of myocardial necrosis which was verified by biochemical, electrophysiological and histological changes in the control animals. Verapamil embolised completely the elevation of creatine-kinase, lactate-dehydrogenase and alpha-hydroxybutyrate-dehydrogenase plasma activity, Q-waves and ST-segment elevations in ECG as well as the coagulation necrosis and myocytolysis. Nifedipine failed to exerts any protective effect, making the biochemical alteration even more pronounced.
authors: Institut za fiziologiju i biohemiju Dr Aleksandar Sabovljev, Medicinski fakultet, Sarajevo.
authors: P
authors: P
authors: Ljubuncić
authors: M P
authors: MP
authors: Stojiljković
authors: M
authors: M
authors: Winterhalter-Jadrić
authors: F
authors: F
authors: Mujić
authors: Z
authors: Z
authors: Vidović
mesh_terms: D000818:Animals; D004562:Electrocardiography / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D007545:Isoproterenol / Q000633:toxicity*; D008297:Male; D009206:Myocardium / Q000473:pathology; D009543:Nifedipine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014700:Verapamil / Q000494:pharmacology*
chemical_list: D014700:Verapamil; D009543:Nifedipine; D007545:Isoproterenol
vernacular_title: Uticaj kalcijumskih antagonista na kardiotoksicne efekte izoprenalina u pacova.