Epitestosterone--a potent competitive inhibitor of C21-steroid side chain cleavage in the testis.
Epitestosterone (17 alpha-hydroxy-4-androsten-3-one) inhibits both 17 alpha-hydroxylation and consequent side chain cleavage of the resulting 17 alpha-hydroxyprogesterone in the rat testicular microsomes. The inhibitory activity in terms of the Ki is 2 and 1.5 times as high, respectively, as that of cyproterone acetate.
Bicíková
M
M
Institute of Endocrinology, Praha, Czechoslovakia.
Hampl
R
R
Stárka
L
L
D000818:Animals; D003534:Cyproterone / Q000378:metabolism; D004845:Epitestosterone / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008861:Microsomes / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism; D051381:Rats; D013737:Testis / Q000187:drug effects*; D013739:Testosterone / Q000096:biosynthesis
D013739:Testosterone; D004845:Epitestosterone; D003534:Cyproterone; D006899:Mixed Function Oxygenases