[Status of the peroxidation-anti-oxidation system in patients with sarcoidosis of the respiratory organs].
Parameters of lipid peroxidation (LPO) and of the antioxidant system (AOS) were analysed according to the level of diene conjugates (DC) and blood serum antiradical activity (ARA), respectively. Study included 115 patients with active respiratory sarcoidosis. The DC level was found to be significantly increased in 89-97% ot the examined patients. At the same time, the ARA changes had a differently directed pattern. The DC/ARA coefficient was estimated which was also increased in most patients providing evidence on the peroxide-antioxidant system imbalance in active sarcoidosis patients. It was found that the parameters were dependent on the process duration. They were studied in dynamics against the background of combined therapy in 2-4-6 months and in the remote periods (1-2 years). Dynamic changes in the biochemical parameters had the unidirectional pattern with manifestation of the clinical and X-ray process dynamics. There was a significant difference in the rate and degree of changes in the LPO-AOS parameters depending on the activity degree of sarcoidosis process and treatment effectiveness. It is believed that the antioxidant therapy is necessary in all sarcoidosis forms at the early stages of treatment and that its duration should be no less than 4 months in the acute process while the protracted course requires a longer period of time.
Obrosova
T I
TI
Kostina
Z I
ZI
Kotenko
T V
TV
D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D003131:Combined Modality Therapy; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008171:Lung Diseases / Q000378:metabolism* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000378:metabolism* / Q000628:therapy; D014811:Vitamin E Deficiency / Q000209:etiology / Q000378:metabolism*
D000975:Antioxidants; D005609:Free Radicals
Sostoianie perekisno-antioksidantnoĭ sistemy u bol'nykh sarkoidozom organov dykhaniia.