EEG frequency and time domain mapping study of the cortical projections of temporal lobe amygdala afterdischarge during kindling in the cat.
EEG frequency and time domain color maps were computed during amygdala kindling in cats. The pattern of the amygdala afterdischarge (AM/AD) propagation to the cortex was assessed as kindling evolved. Our results show that the AM/AD has 4 components that coincide with the activation of certain cortical areas during specific behavioral stages. The pattern of the cortical projection follows an asymmetrical temporo-fronto-occipital direction, the ipsilateral temporal lobe being the first activated zone, followed by the ipsilateral and contralateral prefrontal areas. The contralateral temporal activation is a late phenomenon. We conclude that the electrographic and behavioral manifestations of this model of complex partial epilepsy are asymmetrical during the whole process, including the convulsive stage.
Fernández-Mas
R
R
División de Neurociencias, Instituto Mexicano de Psiquiatría, D.F.
Martínez
A
A
Gutiérrez
R
R
Fernández-Guardiola
A
A
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001931:Brain Mapping; D002415:Cats; D002540:Cerebral Cortex / Q000502:physiology*; D004566:Electrodes; D004569:Electroencephalography / Q000187:drug effects*; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology; D012044:Regression Analysis; D013238:Stereotaxic Techniques; D013702:Temporal Lobe / Q000502:physiology*