[Myopathy associated with infection by the human immunodeficiency virus type-1 (HIV-1)].
We present a case of an active homosexual patient who was a paid donor of plasma and presented myopathy associated to infection by the human immunodeficiency virus type 1 (HIV-1). In the ultrastructural study of the muscular biopsy, we stress the formation of central intermyofibrillary "minocores", as well as the presence of nuclear extrusions in which the core is surrounded by mitochondrial accumulations. We review the clinical, histological and ultrastructural characteristics used to identity this pathology against the group of myopathies induced by zidovudine, as well as the several empirical therapies currently recommended.
Gabriel Botella
F
F
Servicio de Medicina Interna, Hospital Clínico Universitario, Valencia.
Rosello Sastre
E
E
Labios Gómez
M
M
Carda Batalla
C
C
Balaguer Martínez
J V
JV
Arnal Babiloni
M
M
D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D001706:Biopsy; D015483:HIV Antibodies / Q000097:blood; D015497:HIV-1; D006801:Humans; D008168:Lung / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000648:ultrastructure; D009135:Muscular Diseases / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D011020:Pneumonia, Pneumocystis / Q000150:complications / Q000175:diagnosis / Q000473:pathology
D015483:HIV Antibodies
Miopatía asociada a la infección por el virus de la inmunodeficiencia humana tipo-1 (VIH-1).