Platelets and cancer metastasis: more than an epiphenomenon.
In this review we have presented overwhelming evidence that platelets play an important enhancing role in tumor cell-vasculature interactions and cancer metastasis. Tumor cells employ a host of mechanisms to induce platelet aggregation; vice versa, platelets make use of a spectrum of mechanisms to modulate tumor cell-EC and tumor cell-ECM interactions. Various COX and LOX metabolites are closely involved in this bidirectional modulation, thus providing us with a very promising therapeutic avenue by modifying the actions of these metabolites. On the other hand, adhesion molecules are mediators of tumor cell-platelet-EC interactions; therefore interference with these adhesion molecules and various adhesive processes either by soluble peptides, nonpeptidic analogues, or specific antibodies holds great investigational and clinical appeal.
Honn
K V
KV
Department of Radiation Oncology, Wayne State University, Detroit, MI 48202.
Tang
D G
DG
Chen
Y Q
YQ
D001792:Blood Platelets / Q000473:pathology* / Q000502:physiology; D002450:Cell Communication / Q000502:physiology; D004730:Endothelium, Vascular / Q000473:pathology*; D005109:Extracellular Matrix / Q000473:pathology; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D009362:Neoplasm Metastasis / Q000517:prevention & control*