Protection by chlorpromazine against lethality and renal toxicity of cisplatin in mice.
The effect of chlorpromazine on acute lethal toxicity and nephrotoxicity induced by cisplatin was studied in mice. Chlorpromazine given (i.p.) 1 h before cisplatin greatly reduced lethal and renal toxicities of cisplatin. Chlorpromazine did not reduce the antitumor activity of cisplatin against Sarcoma 180 in ddY mice or EL-4 Leukemia in C57BL/6J mice.
Ishikawa
M
M
Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
Ozaki
M
M
Takayanagi
Y
Y
Sasaki
K
K
D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology*; D002945:Cisplatin / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects*; D007942:Leukemia, Experimental / Q000188:drug therapy; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D012510:Sarcoma 180 / Q000188:drug therapy
D002945:Cisplatin; D002746:Chlorpromazine