title: Oligonucleotide sequences required for natural killer cell activation.
abstract: Based on the previous finding that certain 30-mer single-stranded oligodeoxyribonucleotides (oligonucleotides) having particular 6-mer palindromic sequences could induce interferon-alpha and -gamma, and enhance natural killer activity, the present study was carried out to clarify the entire relationship between the activity and the sequence of 30-mer oligonucleotides. The results indicated that the activity depended critically on the presence of particular palindromic sequences including the 5'-CG-3' motif(s). The size and the number of palindromes as well as the extra-palindromic sequences also influenced the activity. An oligonucleotide with a 10-mer palindrome and extra-palindromic oligoguanylate sequences showed the strongest activity among the oligonucleotides tested.
authors: Mitsui Pharmaceuticals, Inc., Institute of Biological Science, Chiba.
authors: E
authors: E
authors: Kuramoto
authors: O
authors: O
authors: Yano
authors: Y
authors: Y
authors: Kimura
authors: M
authors: M
authors: Baba
authors: T
authors: T
authors: Makino
authors: S
authors: S
authors: Yamamoto
authors: T
authors: T
authors: Yamamoto
authors: T
authors: T
authors: Kataoka
authors: T
authors: T
authors: Tokunaga
mesh_terms: D000818:Animals; D001483:Base Sequence; D007694:Killer Cells, Natural / Q000187:drug effects / Q000502:physiology*; D008213:Lymphocyte Activation / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D009841:Oligonucleotides / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013329:Structure-Activity Relationship
chemical_list: D009841:Oligonucleotides