[Immune reactivity disorders in poisoning by the pyrethroid sumi-alpha].
After subchronic intoxication with synthetic sumi-alpha pirethroid rats developed pronounced changes of macrophagocytic function; reduction of cell-mediated and humoral immunity, accumulation of pathogenic circulating immune complexes. In these conditions one-week thymalin treatment produced a normalizing effect. Sodium nucleinate was of low efficacy.
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D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D007154:Immune System Diseases / Q000139:chemically induced* / Q000188:drug therapy; D007111:Immunity, Cellular / Q000187:drug effects; D009570:Nitriles; D009696:Nucleic Acids / Q000627:therapeutic use; D011041:Poisoning / Q000188:drug therapy / Q000276:immunology; D011722:Pyrethrins / Q000506:poisoning*; D051381:Rats; D017208:Rats, Wistar; D013951:Thymus Hormones / Q000627:therapeutic use; D013997:Time Factors
D000276:Adjuvants, Immunologic; D009570:Nitriles; D009696:Nucleic Acids; D011722:Pyrethrins; D013951:Thymus Hormones; C032805:thymalin; C013683:sodium nucleinate; C017690:fenvalerate
Narusheniia immunnoĭ reaktivnosti pri intoksikatsii piretroidom sumi-al'fa.