Follicular mucinosis in alopecia areata.
The pathological features of alopecia areata were described in association with those of follicular mucinosis in the scalp pathology of an 18-year-old woman. The immunohistochemical picture of the inflammatory infiltrate showed a high CD4/CD8 ratio (25:1), which was significantly different from the CD4/CD8 ratio in patients with alopecia areata. The abundance of helper/inducer cells along with the involvement of the upper part of the hair follicles might explain the development of follicular mucinosis in this case. Different possibilities were discussed, but the clinical presentation and the follow-up favored the clinical and pathological interpretation of alopecia areata with incidental findings of follicular mucinosis.
Fanti
P A
PA
Department of Dermatology, University of Bologna, Italy.
Tosti
A
A
Morelli
R
R
Cameli
N
N
Sabattini
E
E
Pileri
S
S
D000293:Adolescent; D000506:Alopecia Areata / Q000150:complications* / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D000507:Mucinosis, Follicular / Q000150:complications* / Q000276:immunology / Q000473:pathology; D012535:Scalp / Q000473:pathology; D016176:T-Lymphocyte Subsets