Biphenomycin A production by a mixed culture.
Production of biphenomycin A by Streptomyces griseorubiginosus 43708 was stimulated by a mixed culture with a partner strain, Pseudomonas maltophilia 1928. This stimulatory effect on biphenomycin A accumulation by the mixed culture was caused by the enzyme activity which strain 1928 possessed. It is suggested that in a mixed culture strain 43708 produces a precursor of biphenomycin A in culture broth and that strain 1928 converts the precursor to biphenomycin A.
Ezaki
M
M
Exploratory Research Laboratory, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
Iwami
M
M
Yamashita
M
M
Komori
T
T
Umehara
K
K
Imanaka
H
H
D000900:Anti-Bacterial Agents / Q000378:metabolism*; D023181:Antimicrobial Cationic Peptides; D001431:Bacteriological Techniques; D004151:Dipeptides / Q000096:biosynthesis; D005069:Evaluation Studies as Topic; D010455:Peptides; D011549:Pseudomonas / Q000145:classification / Q000378:metabolism*; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D004151:Dipeptides; D010455:Peptides; C047536:biphenomycin A