[Changes in the humoral systems in juvenile arterial hypertension and their correction by using nifedipine and anaprilin].
Examined were 140 adolescents with juvenile arterial hypertension (JAH) and 54 healthy adolescents (age: 15-19 years). Niphedipine was used in 36, anaprilin in 40; 60--did not receive these drugs (control group). The treatment lasted 6 months. It was found that before treatment adolescents with JAH showed a clear increase of the angiotensin, testosterone and plasma renin activity (PRA). Niphedipine treatment resulted in normalization of the angiotensin level, while anaprilin treatment resulted in normalization of PRA and testosterone. The two drugs reduced equally the level of arterial pressure.
Bihar
P V
PV
D000293:Adolescent; D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II / Q000097:blood / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D004341:Drug Evaluation; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D009543:Nifedipine / Q000627:therapeutic use*; D011433:Propranolol / Q000627:therapeutic use*; D012083:Renin / Q000097:blood / Q000187:drug effects; D012084:Renin-Angiotensin System / Q000187:drug effects*; D013739:Testosterone / Q000097:blood
D000804:Angiotensin II; D013739:Testosterone; D000450:Aldosterone; D011433:Propranolol; D012083:Renin; D009543:Nifedipine
Zmina deiakykh humoral'nykh system pry iuvenil'niĭ arterial'niĭ hipertenziï i ïï korektsiia z dopomohoiu nifedypinu i anaprylinu.