N-methyl-D-aspartic acid injected peripherally stimulates oxytocin and vasopressin release.
The effects of N-methyl-D-aspartic acid (NMDA), injected s.c. or i.p. in the dose range of 2.5-10 mg/kg, on oxytocin and vasopressin levels were assessed in conscious rats. NMDA administration was found to induce a dose-related increase in oxytocin concentration with a peak response at 7.5 min. Plasma vasopressin was elevated only after injection of the highest dose used (10 mg/kg). Thus, though at different thresholds, the release of both posterior pituitary hormones was stimulated after NMDA administration.
Jezová
D
D
Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava.
Michajlovskij
N
N
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D008297:Male; D016202:N-Methylaspartate / Q000008:administration & dosage / Q000494:pharmacology*; D010121:Oxytocin / Q000187:drug effects* / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014667:Vasopressins / Q000187:drug effects* / Q000378:metabolism*
D014667:Vasopressins; D010121:Oxytocin; D016202:N-Methylaspartate