title: Pharmacodynamics and pharmacokinetics of cyclosporin A in the newborn pig.
abstract: The disposition kinetics of cyclosporin A in the neonates as well as age-related differences in lymphocyte responses to cyclosporin A are unknown. A single intravenous infusion of cyclosporin A was given to neonatal (2.5 or 5 mg/kg) and mature pigs (10 mg/kg) and blood cyclosporin A levels were measured by RIA. The neonates had longer elimination half-life and lower drug clearance than mature animals. Suppression in lymphocyte proliferation was only observed in mixed lymphocyte reaction and phytohemagglutinin-stimulated cultures of the 2-hour samples from neonates receiving 5 mg/kg. We conclude that neonatal pig exhibit different cyclosporin A pharmacokinetics and show higher sensitivity to cyclosporin A than mature animals.
authors: Department of Cardiovascular Research, Hospital for Sick Children, Toronto, Canada.
authors: P W
authors: PW
authors: Tsao
authors: S
authors: S
authors: Ito
authors: P Y
authors: PY
authors: Wong
authors: I C
authors: IC
authors: Radde
authors: S
authors: S
authors: Bryson
authors: D S
authors: DS
authors: Young
authors: J
authors: J
authors: Caspi
authors: R J
authors: RJ
authors: Diaz
authors: M F
authors: MF
authors: Martell
authors: J M
authors: JM
authors: Augustine
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D002455:Cell Division; D002478:Cells, Cultured; D016572:Cyclosporine / Q000493:pharmacokinetics* / Q000494:pharmacology*; D007262:Infusions, Intravenous; D008214:Lymphocytes / Q000187:drug effects*; D013552:Swine
chemical_list: D016572:Cyclosporine