Chemical carcinogenesis in the thyroid gland.
Chemical carcinogens and promoters in thyroid carcinogenesis may be divided into two types, one having goitrogenic effects, the other not having these effects e.g. phenobarbital, 4,4'-diaminodiphenylmethane. The influence of sex hormones like estrogen and testosterone remains unclear, although some thyroid tumors have estrogen receptors. Further studies in this area are necessary.
Hiasa
Y
Y
Second Department of Pathology, Nara Medical University, Japan.
Kitahori
Y
Y
Konishi
N
N
Ohshima
M
M
D000818:Animals; D012739:Gonadal Steroid Hormones / Q000502:physiology; D009602:Nitrosamines; D051381:Rats; D013964:Thyroid Neoplasms / Q000139:chemically induced*; D013972:Thyrotropin / Q000097:blood
D012739:Gonadal Steroid Hormones; D009602:Nitrosamines; C012457:diisopropanolnitrosamine; D013972:Thyrotropin