Cajucarinolide and isocajucarinolide: anti-inflammatory diterpenes from Croton cajucara.
Cajucarinolide and isocajucarinolide, two new clerodane diterpenes, have been isolated from the cortices of Croton cajucara (Euphorbiaceae). These compounds possess anti-inflammatory activity and inhibit bee venom phospholipase A2 in vitro.
Ichihara
Y
Y
Department of Pharmacognosy, Tokyo College of Pharmacy, Japan.
Takeya
K
K
Hitotsuyanagi
Y
Y
Morita
H
H
Okuyama
S
S
Suganuma
M
M
Fujiki
H
H
Motidome
M
M
Itokawa
H
H
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D010741:Phospholipases A / Q000037:antagonists & inhibitors; D054467:Phospholipases A2; D010944:Plants / Q000737:chemistry*; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004224:Diterpenes; D013141:Spiro Compounds; C079174:isocajucarinolide; C079173:cajucarinolide; D010741:Phospholipases A; D054467:Phospholipases A2