[IgA-class antigliadin antibodies in the screening and follow-up of celiac disease patients].
IgA antigliadin antibodies (IgA-AGA) have been determined with an enzyme immunoassay in 2.141 pediatric patients. High levels of IgA were found in 98% of 53 celiac patients (1st biopsy), in 81% of 16 celiac patients after gluten challenge, while high levels of these antibodies were not found in 200 patients on gluten-free diet. Moreover high levels of IgA-AGA were found in 29% of 48 patients with normal jejunal biopsy and in 4% of 1.824 patients with gastrointestinal problems other than celiac disease. Our results confirm the data report in literature about the sensibility and the specificity of the IgA-AGA dosage as a screening test for celiac disease, but the possibility of false pathological and false normal values confirms the intestinal biopsy, as the main procedure for the diagnosis of celiac disease.
Papadatou
B
B
Divisione di Gastroenterologia, Ospedale Bambino Gesù, Roma, Italia.
Ferretti
F
F
Colistro
F
F
Castellucci
G
G
Lucidi
V
V
Ricci
S
S
Cerminara
R
R
Bella
S
S
Colombo
A M
AM
Gambarara
M
M
D000906:Antibodies / Q000097:blood*; D002446:Celiac Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay / Q000706:statistics & numerical data; D005500:Follow-Up Studies; D005903:Gliadin / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D012680:Sensitivity and Specificity
D000906:Antibodies; D007070:Immunoglobulin A; D005903:Gliadin
Gli anticorpi antigliadina della classe IgA nello screening e nel follow-up dei pazienti celiaci.