Fat emulsion particle-size distribution in total nutrient admixtures.
The fat particle-size distribution in and physical stability of two commercially available lipid emulsions before and after their use in total nutrient admixtures (TNAs) are reported. Four TNAs without electrolytes and four TNAs with electrolytes were prepared; each type of TNA was prepared with Liposyn II and with Intralipid. Particle size was measured in the < 1-micron range by using photon correlation spectroscopy and in the 2-60-microns range by using light blockage. Admixtures with or without electrolytes were stored for two or nine days at 4 degrees C followed by one day at 25 degrees C. For the fraction of fat particles of < 1 micron in diameter, Intralipid and Liposyn II had a mean particle size of 374 and 313 nm, respectively. The admixtures containing electrolytes showed a decrease in mean particle size of about 7%. Admixtures with Intralipid contained 2 x 10(7) particles larger than 2 microns per milliliter (1.7% of total fat), compared with 1 x 10(6) particles per milliliter (0.05-0.15% of total fat) for admixtures with Liposyn II. The addition of electrolytes increased the particle counts for Liposyn II-containing admixtures. Upon storage, Intralipid-containing admixtures with electrolytes showed an initial increase followed by a decrease in the mean diameter of particles of < 1 micron. All the admixtures were stable in terms of pH and visual appearance. Intralipid-containing admixtures with electrolytes showed a decrease in the number of particles in the 2-60-microns size range, while Liposyn II-containing admixtures with electrolytes showed an increase.(ABSTRACT TRUNCATED AT 250 WORDS)
Mehta
R C
RC
College of Pharmacy, University of Kentucky, Lexington 40536-0082.
Head
L F
LF
Hazrati
A M
AM
Parr
M
M
Rapp
R P
RP
DeLuca
P P
PP
D004344:Drug Incompatibility; D004355:Drug Stability; D004573:Electrolytes / Q000737:chemistry; D005217:Fat Emulsions, Intravenous / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D010289:Parenteral Nutrition, Total; D010316:Particle Size
D004573:Electrolytes; D005217:Fat Emulsions, Intravenous