Local perineal implants of anti-androgen block masculinization of the spinal nucleus of the bulbocavernosus.
Female rats were injected with testosterone propionate on the 1st and 3rd days of life. In addition, some females received 200 micrograms of the anti-androgen, hydroxyflutamide. Females receiving anti-androgen directly to the perineum, including the muscles bulbocavernosus and levator ani, had fewer surviving spinal nucleus of the bulbocavernosus (SNB) motoneurons than did females receiving the anti-androgen systemically. These results indicate that androgen acts upon the target muscles to spare developing SNB motoneurons from death.
Fishman
R B
RB
Department of Psychology, University of California, Berkeley 94720.
Breedlove
S M
SM
D000818:Animals; D005314:Embryonic and Fetal Development / Q000187:drug effects; D005260:Female; D005485:Flutamide / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D007267:Injections; D009046:Motor Neurons / Q000166:cytology / Q000502:physiology; D009132:Muscles / Q000294:innervation; D010502:Perineum; D051381:Rats; D012733:Sex Differentiation / Q000187:drug effects*; D013116:Spinal Cord / Q000166:cytology / Q000196:embryology*; D013739:Testosterone / Q000008:administration & dosage
C014290:hydroxyflutamide; D013739:Testosterone; D005485:Flutamide