Evaluation of the blood-aqueous barrier after vitreous replacement with perfluoropropane gas and liquid silicone.
Fluorophotometric measurements of blood-aqueous barrier permeability after intravitreal injection of perfluoropropane gas in rabbit eyes revealed fluorescein leakage immediately after injection; 3 days later, recovery of barrier integrity had begun to occur and 7 days and 14 days after gas injection, when the gas bubble was still in the eye, anterior chamber fluorescein concentrations were normal. Similarly, in eyes undergoing vitrectomy and injection of silicone liquid or vitrectomy only, anterior chamber fluorescein levels were elevated 3 days and 1 week after surgery. Nevertheless, normal barrier integrity was reestablished in both the silicone-filled eyes and the vitrectomized eyes after 1 week. Since there was no difference between the group injected with silicone and the group that underwent vitrectomy only with respect to anterior chamber fluorescein concentration at any of the times studied, it is concluded that the temporary disruption of the blood-aqueous barrier is associated with the surgical procedure rather than the presence of silicone liquid in the vitreous cavity.
Sparrow
J R
JR
Margaret M. Dyson Vision Research Institute, Department of Ophthalmology, Cornell University Medical College, New York, New York 10021.
Chang
S
S
Vinals
A F
AF
D000818:Animals; D000867:Anterior Chamber / Q000378:metabolism; D001082:Aqueous Humor / Q000378:metabolism*; D001693:Biological Transport, Active; D001769:Blood / Q000378:metabolism*; D002463:Cell Membrane Permeability; D019793:Fluorescein; D005452:Fluoresceins / Q000378:metabolism; D005466:Fluorocarbons / Q000493:pharmacokinetics*; D015590:Fluorophotometry; D007267:Injections; D011817:Rabbits; D012827:Silicone Oils / Q000493:pharmacokinetics*; D014821:Vitrectomy
D005452:Fluoresceins; D005466:Fluorocarbons; D012827:Silicone Oils; C042852:perflutren; D019793:Fluorescein