title: Reduced left ventricular diameters at onset of bradycardia during epidural anaesthesia.
abstract: Pathophysiologic mechanisms of bradycardia during epidural anaesthesia (L3-L4 with 1% lidocaine, 38 ml) were evaluated by studying changes in selected cardiovascular and hormonal parameters. Six of eight subjects (analgesia to T8-T10) remained circulatory stable with no significant changes in heart rate (HR), mean arterial pressure (MAP) and thoracic impedance (TI). In one of two subjects MAP decreased after 25 min from 85 to 50 mmHg (11.3 to 6.7 kPa), HR from 80 to 45 beats.min-1 while thoracic impedance increased from 25.5 to 26.5 ohm. End-systolic diameter (ESD) and end-diastolic diameter (EDD) of the left ventricle determined with echocardiography were reduced from 3.8 to 3.2 cm (17%) and 5.6 to 5.0 cm (11%), respectively. In the other subject MAP decreased after 25 min from 75 to 50 mmHg (10.0 to 6.7 kPa) and HR from 82 to 60 beats.min-1 while thoracic impedance increased from 28.8 to 29.6 ohm. ESD was reduced from 3.8 to 3.3 cm (13%), and EDD from 5.6 to 5.0 cm (11%). Both subjects recovered after infusion of saline and being placed in the head-down position. There were no consistent changes in plasma catecholamines, whereas pancreatic polypeptide increased from 5 and 3 to 152 and 69 pmol.l-1, vasopressin from 3 and 2 to 152 and 46 pmol.l-1, and aldosterone from 282 and 229 to 383 and 485 pmol.l-1, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
authors: Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Denmark.
authors: J
authors: J
authors: Jacobsen
authors: S
authors: S
authors: Søfelt
authors: V
authors: V
authors: Brocks
authors: A
authors: A
authors: Fernandes
authors: J
authors: J
authors: Warberg
authors: N H
authors: NH
authors: Secher
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood; D000767:Anesthesia, Epidural; D001127:Arginine Vasopressin / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D001919:Bradycardia / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology*; D002302:Cardiac Output / Q000187:drug effects / Q000502:physiology; D002307:Cardiography, Impedance / Q000187:drug effects; D004452:Echocardiography; D004837:Epinephrine / Q000097:blood; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000097:blood; D010191:Pancreatic Polypeptide / Q000097:blood; D013318:Stroke Volume / Q000187:drug effects / Q000502:physiology; D016277:Ventricular Function, Left / Q000187:drug effects / Q000502:physiology*
chemical_list: D001127:Arginine Vasopressin; D000450:Aldosterone; D010191:Pancreatic Polypeptide; D008012:Lidocaine; D009638:Norepinephrine; D004837:Epinephrine