Investigations into a new antiarrhythmic substance Z-2-amino-5-chlor-benzophenon-amidin-hydralazin in humans.
Z-2-amino-5-chlor-benzophenon-amidin-hydralazin is a new chemical potential antiarrhythmic substance. The blood levels were investigated after different dosages and forms of administration in patients and volunteers. The determination of the substance can be performed by high-pressure liquid chromatography. In addition the pharmacokinetic parameters were calculated. The pharmacokinetic profile is similar in humans and animals.
Farker
K
K
Institute of Clinical Pharmacology, Friedrich-Schiller-University Jena, Germany.
Henschel
L
L
Marschner
J P
JP
Reimann
I
I
Volkmann
H
H
Hoffmann
A
A
D000284:Administration, Oral; D000889:Anti-Arrhythmia Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D006830:Hydralazine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D007275:Injections, Intravenous; D007408:Intestinal Absorption; D008297:Male; D013610:Tachycardia / Q000188:drug therapy / Q000378:metabolism*
C079369:2-amino-5-chlorobenzophenonamidinohydralazine; D000889:Anti-Arrhythmia Agents; D006830:Hydralazine