Hormonal status in postmenopausal androgenetic alopecia.
The development of androgenetic alopecia is thought to be caused by increased androgen action on hair follicles with menopause. Testosterone, estradiol and sex hormone binding globulin (SHBG) serum levels were determined in ten postmenopausal women with androgenetic alopecia and in ten sex and age matched healthy controls. No statistically significant differences were found in the hormone levels between the patients and the controls. These findings suggest that a genetically determined functional alteration of androgen receptors and/or a metabolic disturbance may exist in the hair follicle keratinocytes in androgenetic alopecia.
Georgala
S
S
Department of Dermatology, University of Athens, Greece.
Gourgiotou
K
K
Kassouli
S
S
Stratigos
J D
JD
D000368:Aged; D000505:Alopecia / Q000097:blood* / Q000209:etiology; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D008593:Menopause / Q000097:blood*; D008875:Middle Aged; D012738:Sex Hormone-Binding Globulin / Q000032:analysis*; D013739:Testosterone / Q000097:blood*
D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D004958:Estradiol