Solidifying liquid with novel initiation system for detachable balloon catheters.
In endovascular surgery, to permanently hinder blood inflow into an aneurysm for example, a catheter is percutaneously introduced into an artery and the balloon is positioned and inflated by a solidifying liquid and then released into the diseased part. A novel solidifying liquid for the inflated balloon curable under the continuous feeding of oxygen through the wall of the balloon is described here. Glucose oxidase which oxidizes glucose producing hydrogen peroxide was used for polymerization of the solidifying liquid. This solidifying liquid cured even in the presence of oxygen and water. It was radiopaque when mixed with the iodinated X-ray contrast chemical iopamidol. In addition, the solidified liquid had appropriate mechanical properties. The endovascular surgery could be carried out safely using it.
Iwata
H
H
Department of Surgical Research, National Cardiovascular Center, Osaka, Japan.
Hata
Y
Y
Matsuda
T
T
Taki
W
W
Yonekawa
Y
Y
Ikada
Y
Y
D002404:Catheterization / Q000295:instrumentation / Q000379:methods*; D002533:Cerebral Angiography; D005949:Glucose Oxidase; D006801:Humans; D002532:Intracranial Aneurysm / Q000628:therapy*; D007700:Kinetics; D008297:Male; D008689:Methacrylates; D008875:Middle Aged; D011108:Polymers
D008689:Methacrylates; D011108:Polymers; C005044:hydroxyethyl methacrylate; D005949:Glucose Oxidase