Aldosterone responses to angiotensin II in anorexia nervosa.
Patients with anorexia nervosa (AN) tend to have renin-angiotensin-aldosterone (RAA) abnormalities caused by abnormal behaviors such as strict dieting, fasting, vigorous exercise, self-induced vomiting and abuse of laxatives and/or diuretics. Adrenal responsiveness to angiotensin II (A II) was studied in 13 AN patients before and after therapy and in 6 normal sex- and age-matched controls: adrenal responses to postural change (1 h of walking following 1 h in a supine position) and to exogenous A II injection (A II: 10 ng/kg/min intravenous infusion for 30 min). The 24-h urine sodium concentration was significantly lower in AN patients before therapy than after therapy. Plasma aldosterone secretory response to A II was significantly higher in AN patients before therapy in both postural change and exogenous A II injection tests compared with after therapy response and that of controls. On the other hand, there was no significant difference in adrenal response to postural change or to exogenous A II between AN patients after therapy and controls. In conclusion, increased A II sensitivity caused by chronic sodium deficiency in AN patients normalized over time as the patients recovered.
Mizuno
O
O
Department of Psychosomatic Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Tamai
H
H
Fujita
M
M
Kobayashi
N
N
Komaki
G
G
Matsubayashi
S
S
Nakagawa
T
T
D000328:Adult; D000450:Aldosterone / Q000097:blood*; D000804:Angiotensin II; D000856:Anorexia Nervosa / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D001835:Body Weight / Q000502:physiology; D015928:Cognitive Behavioral Therapy; D004573:Electrolytes / Q000097:blood; D005080:Exercise Test; D005260:Female; D006801:Humans; D012084:Renin-Angiotensin System / Q000502:physiology; D014882:Water-Electrolyte Balance / Q000502:physiology*
D004573:Electrolytes; D000804:Angiotensin II; D000450:Aldosterone