Suppressed serum and urine levels of indoxyl sulfate by oral sorbent in experimental uremic rats.
In uremic patients, the serum concentration of indoxyl sulfate is markedly increased. To determine if oral sorbent (AST-120) suppresses the endogenous synthesis of indoxyl sulfate, it was administered to experimental uremic rats, and the serum concentration and urinary excretion of indoxyl sulfate were quantified by high-performance liquid chromatography. Oral sorbent decreased both the serum concentration and urinary excretion of indoxyl sulfate, suggesting that there was suppression of the endogenous synthesis of indoxyl sulfate by the oral sorbent. Oral sorbent did not decrease the serum concentration and urinary excretion of hippuric acid, but it did alleviate the deterioration of renal function in the experimental uremic rats.
Niwa
T
T
Department of Internal Medicine, Nagoya University Branch Hospital, Japan.
Miyazaki
T
T
Hashimoto
N
N
Hayashi
H
H
Ise
M
M
Uehara
Y
Y
Maeda
K
K
D000327:Adsorption; D000818:Animals; D002244:Carbon / Q000627:therapeutic use*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006626:Hippurates / Q000378:metabolism; D007200:Indican / Q000378:metabolism*; D007421:Intestine, Small / Q000378:metabolism; D007668:Kidney / Q000503:physiopathology; D008099:Liver / Q000378:metabolism; D010087:Oxides / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014511:Uremia / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology
D006626:Hippurates; D010087:Oxides; D002244:Carbon; C040896:AST 120; D007200:Indican; C030514:hippuric acid