Are sense-antisense peptide interactions between HIV-1 (gp120), CD4, and the proto oncogene product p56lck important?
The finding that codons for hydrophobic and hydrophilic amino acids are generally complemented by codons for hydrophilic and hydrophobic amino acids respectively has led to a novel observation. The antisense peptides coded for by the complementary DNA strand of biologically active peptides are able to bind their active sense counterparts with high specificity. Sense-antisense relationships have been observed in several peptide species as well as in receptor-ligand interactions. The idea that sense-antisense interactions are biologically relevant and indeed feasible among complex molecules prompts the examination of virus-host cell interactions. We propose such a sense-antisense interaction exists between the HIV glycoprotein gp120 and the intracellular domain of the HIV receptor CD4. This interaction is at a site which may be occupied by the proto oncogene product p56lck.
Brown
R
R
Department of Psychology, University of Newcastle, Callaghan, Australia.
Meldrum
C
C
Cousins
S
S
D000595:Amino Acid Sequence; D001483:Base Sequence; D001665:Binding Sites; D015704:CD4 Antigens / Q000235:genetics / Q000378:metabolism; D003062:Codon / Q000235:genetics; D016373:DNA, Antisense / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D015699:HIV Envelope Protein gp120 / Q000235:genetics* / Q000378:metabolism; D015658:HIV Infections / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck); D008969:Molecular Sequence Data; D009856:Oncogene Proteins, Viral / Q000235:genetics / Q000378:metabolism; D010455:Peptides / Q000235:genetics / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D000090063:Proto-Oncogene Mas
D015704:CD4 Antigens; D003062:Codon; D016373:DNA, Antisense; D004279:DNA, Viral; D015699:HIV Envelope Protein gp120; C000715470:MAS1 protein, human; D009856:Oncogene Proteins, Viral; D010455:Peptides; D000090063:Proto-Oncogene Mas; D011505:Protein-Tyrosine Kinases; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck)