Presence of single-chain ribosome-inactivating protein-like activities in several plant species.
The present screening work was devoted to the search for new ribosome-inactivating proteins (RIPs) in 21 plant species. Eight plants proved to be very active, inhibiting protein synthesis in eukaryotic in vitro systems (rat liver, Vicia sativa and wheat germ). They fulfil the major requirements for consideration as type 1 RIPs. Also, eight plants were found to contain haemagglutinating activity of human red cells but this was not related to the simultaneous presence of RIPs.
Girbés
T
T
Departamento de Bioquímica, Biología Molecular y Fisiología, Facultad de Ciencias, Universidad de Valladolid, Spain.
Citores
L
L
Prieto
M T
MT
Ferreras
J M
JM
Muñoz
R
R
Fernández
J M
JM
D000818:Animals; D002474:Cell-Free System; D002853:Chromatography, Liquid; D004912:Erythrocytes / Q000187:drug effects; D006384:Hemagglutination; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D010940:Plant Proteins / Q000494:pharmacology*; D014176:Protein Biosynthesis / Q000187:drug effects*; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D051381:Rats; D012270:Ribosomes / Q000187:drug effects*; D013045:Species Specificity
D010940:Plant Proteins; D011500:Protein Synthesis Inhibitors