title: [Postoperative infection with methicillin-resistant Staphylococcus aureus and its control measures in patients with esophageal cancer--prediction of high risk patients].
abstract: Whether or not compromised host defense prior to surgical treatment is related to development of infection with methicillin-resistant staphylococcus aureus (MRSA) following major surgery was examined. Of 22 patients undergoing esophagectomy for cancer between 1989 and 1990, 5 were free from MRSA colonization and infection (group I) while 8 had MRSA colonization without infection (group II) and 9 had MRSA infection (group III). Levels of neutrophil cytocidal functions, complements, immunoglobulins and cell-mediated immunity were not significantly different among these three groups. The mean of anti pneumococcal polysaccharide (PPS)-IgG was significantly lower in group III than in group I (p < 0.05) and tended to be lower than in group II (P = 0.08). All infected patients showed a titer < 600 EU while all but one non-infected patient did so > 600 EU. Serum IgG2 levels positively correlated with anti-PSS IgG levels. Thus, we concluded that a preoperative evaluation of antibody response against polysaccharides and serum IgG2 levels can serve to predict development of MRSA-related infection following esophageal surgery.
authors: First Department of Surgery, Oita Medical University, Japan.
authors: T
authors: T
authors: Saito
authors: T
authors: T
authors: Kinoshita
authors: Y
authors: Y
authors: Shigemitsu
authors: K
authors: K
authors: Shimoda
authors: M
authors: M
authors: Kobayashi
mesh_terms: D004938:Esophageal Neoplasms / Q000276:immunology / Q000601:surgery*; D006801:Humans; D007111:Immunity, Cellular; D007113:Immunity, Innate; D016867:Immunocompromised Host / Q000276:immunology*; D007074:Immunoglobulin G / Q000032:analysis; D016106:Methicillin Resistance; D011183:Postoperative Complications / Q000517:prevention & control; D012306:Risk; D013203:Staphylococcal Infections / Q000209:etiology* / Q000517:prevention & control; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D007074:Immunoglobulin G