[Effect of misoprostol, a synthetic equivalent of prostaglandin E1, on bronchodilation in bronchial spasm].
A effect of a single dose 400 micrograms misoprostol (Cytotec-Searle) on a degree of the bronchospasm relief has been investigated in 8 patients, and the results have been compared with those produced by aminophylline i.v. infusion in the rate of 500 mg/hour. Prior to and 10, 20, 30, 60, 90, 120, 150 and 180 minutes after administration of both drugs, the following parameters of pulmonary ventilation have been determined: VC, VC%, FEV1, FEV1%, MVV, and MEFR. The results have shown that misoprostol given in a single oral dose of 400 micrograms to patients with bronchospasm has the bronchodilating activity which is statistically significant. However, this activity is rather weak and significantly lower than that of intravenous aminophylline infusion.
Marcisz
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IV Katedry i Kliniki Chorób Wewnetrznych Slaskiem AM, Tychach.
Jonderko
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Gina
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Szkliniarz
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D000284:Administration, Oral; D000328:Adult; D000628:Aminophylline / Q000008:administration & dosage / Q000494:pharmacology; D001980:Bronchi / Q000187:drug effects* / Q000503:physiopathology; D001986:Bronchial Spasm / Q000188:drug therapy* / Q000503:physiopathology; D001993:Bronchodilator Agents; D002000:Bronchospirometry; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D016595:Misoprostol / Q000008:administration & dosage* / Q000494:pharmacology; D012119:Respiration / Q000187:drug effects / Q000502:physiology; D013997:Time Factors
D001993:Bronchodilator Agents; D016595:Misoprostol; D000628:Aminophylline
Wpływ mizoprostolu, syntetycznego odpowiednika prostaglandyny E1 na rozkurcz oskrzeli w stanach skurczowych oskrzeli.