mRNA stability: in trans-it.
The regulation of mRNA stability is an important step in the control of gene expression. Characterization of the mechanisms involved in the turnover of individual mRNAs has identified a requirement for specific cis-acting sequences and trans-acting factors, as well as an involvement of the translation apparatus. In the past year, significant progress has been made in the identification of trans-acting factors by both biochemical and genetic approaches. This review summarizes that progress and promotes the notion that the ribosome itself should also be considered as a trans-acting component of the mRNA decay machinery.
Peltz
S W
SW
University of Massachusetts Medical School, Worcester.
Jacobson
A
A
D000818:Animals; D004722:Endoribonucleases / Q000378:metabolism; D005095:Exoribonucleases / Q000378:metabolism; D011061:Poly A / Q000378:metabolism; D014176:Protein Biosynthesis / Q000235:genetics*; D012333:RNA, Messenger / Q000737:chemistry* / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000502:physiology; D015534:Trans-Activators / Q000502:physiology*
D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D015534:Trans-Activators; D011061:Poly A; D004722:Endoribonucleases; D005095:Exoribonucleases