title: Etomidate shortens the onset time of neuromuscular block.
abstract: We have studied 30 healthy patients allocated randomly to receive thiopentone, propofol or etomidate in equipotent doses followed by vecuronium 0.1 mg kg-1. Haemodynamic variables and time to 100% neuromuscular block were measured. The patients receiving etomidate had a significantly shorter onset time of neuromuscular block compared with those receiving the two other i.v. induction agents. There was a significant negative correlation between onset time of neuromuscular block and the maximum percent change in mean arterial pressure.
authors: Department of Anaesthesia, Odstock Hospital, Salisbury, Wiltshire.
authors: R S
authors: RS
authors: Gill
authors: R P
authors: RP
authors: Scott
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D005045:Etomidate / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D009407:Nerve Block; D009469:Neuromuscular Junction / Q000187:drug effects*; D015742:Propofol / Q000494:pharmacology; D011446:Prospective Studies; D013874:Thiopental / Q000494:pharmacology; D013997:Time Factors
chemical_list: D013874:Thiopental; D015742:Propofol; D005045:Etomidate