Penicillamine-induced pseudoxanthoma elasticum-like skin changes requiring rhytidectomy.
A 42-year-old woman with pronounced skin laxity of her neck underwent a rhytidectomy and was found to have pseudoxanthoma elasticum-like changes of her skin. Her medical history was significant for Wilson's disease, requiring that she take penicillamine for 26 years. In patients on long-term penicillamine therapy, 20% to 33% will develop a dermatopathy. The drug has been used to alter scar formation in various surgical conditions. Penicillamine is known to alter cross-linking of elastin and collagen fibers. A review of the literature reveals other penicillamine-related dermatopathies that may present to the surgeon.
Narron
G H
GH
Department of Plastic and Reconstructive Surgery, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
Zec
N
N
Neves
R I
RI
Manders
E K
EK
Sexton
F M
FM
D000328:Adult; D005148:Facial Dermatoses / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D009333:Neck / Q000473:pathology; D010396:Penicillamine / Q000009:adverse effects*; D011561:Pseudoxanthoma Elasticum / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery*; D015361:Rhytidoplasty; D015595:Skin Aging / Q000187:drug effects
D010396:Penicillamine