Elevated fibrinopeptide A (FPA) in patients with Lesch-Nyhan syndrome.
The detection of elevated fibrinopeptide A (FPA) level in a patient with the Lesch-Nyhan syndrome complicated with cerebral infarction prompted us to examine FPA level in 3 other patients with the syndrome. FPA level significantly increased in all patients. Fibrinopeptide B beta 15-42 (FPB beta 15-42) level was increased in two, and both beta-thromboglobulin (beta TG) and platelet factor 4 (PF4) levels were elevated in one patient. These results suggest coagulation abnormalities in patients with Lesch-Nyhan syndrome.
Imamura
A
A
Division of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, Tokyo, Japan.
Yamanouchi
H
H
Kurokawa
T
T
Arima
M
M
D000293:Adolescent; D000328:Adult; D001779:Blood Coagulation Factors / Q000032:analysis; D002648:Child; D005344:Fibrinopeptide A / Q000032:analysis*; D006801:Humans; D007926:Lesch-Nyhan Syndrome / Q000097:blood*; D008297:Male
D001779:Blood Coagulation Factors; D005344:Fibrinopeptide A