[Indomethacin in threatening premature labor. Fetal and neonatal cardiovascular effects].
At the Hospital de Ginecobstetricia del Centro Medico "La Raza", between october 1, 1990 to may 31, 1991, were attended 50 women with premature labor, with pregnancies of 30-36 week sold. They were given 100 mg of indomethacin, rectal, daily, in order to obtain arrest of the uterine activity. The mean doses given was 4 +/- 0.739. In 26 (52%) patients there were transient, fetal ductal constriction. In these patients there were high fetal heart rate variability during the ductal constriction time. No other fetal an neonatal effects were documented. It is recommended when indomethacin was given in premature labor treatment a fetal ecocardiogram and the fetal and neonatal study of the patients in research of cardiovascular side effects, included neonatal pulmonary hypertension syndrome.
Díaz-Calderon
O
O
Hospital de Gineco-Obstetricia No. 3, Centro Médico La Raza, Instituto Mexicano del Seguro Social, D.F.
Velazco-Olivares
M
M
Danglot-Banck
C
C
Gómez-Gomez
M
M
Covarrubias-Villegas
R
R
D002318:Cardiovascular Diseases / Q000139:chemically induced*; D005260:Female; D005315:Fetal Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging; D006801:Humans; D006976:Hypertension, Pulmonary / Q000139:chemically induced; D007213:Indomethacin / Q000008:administration & dosage* / Q000009:adverse effects; D007231:Infant, Newborn; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D011247:Pregnancy; D016216:Ultrasonography, Prenatal
D007213:Indomethacin
Indometacina en amenaza de parto prematuro. Efectos cardiovasculares fetales y neonatales.