[A comparison of the efficacy of nitrogranulong and other prolonged-action nitrates by using paired bicycle ergometry in patients with stenocardia].
The efficacy of single doses of nitrogranulong, 5.2 mg, trinitrolong, 2 mg, nitrong 6.5 mg, and placebo was evaluated in 10 males aged 46-62 years who had Functional Classes II-III angina on effort. For this, paired bicycle ergometry was employed. In patients in whom nitrogranulong, 5.2 mg, turned out to be ineffective, the effective dose was evaluated as 10.4 mg. The effect of a drug was evaluated from an increase in exercise duration before the occurrence of a moderate anginal attack and/or 1 mm or more ST-segment depression in bicycle ergometry performed when the maximum effect of the single dose was expected than that in bicycle ergometry performed before achieving the same criteria for exercise discontinuation on the same day before the drug use (delta T threshold). The single dose of a drug was considered to be beneficial at delta T threshold > or = 120 sec (individual effects). Trinitrolong in a dose of 2 mg turned out be the most effective: there was the most mean value of delta T threshold and the individual effect was seen in 100% of the patients. According to the accepted criterion, nitrogranulong, 5.2 mg, and nitrong, 6.5 mg, were effective in 20%. Nitrogranulong, 10.4 mg, was beneficial in more 40% of patients; in all the first and the second doses of the drug were beneficial in 60%.
Bochkareva
E V
EV
Kokurina
E V
EV
Metelitsa
V I
VI
Kukushkin
S K
SK
D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D005080:Exercise Test / Q000295:instrumentation / Q000379:methods*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000627:therapeutic use*; D005082:Physical Exertion; D013607:Tablets
D003692:Delayed-Action Preparations; D013607:Tablets; D005996:Nitroglycerin
Sravnenie éffektivnosti nitrogranulonga i drugikh nitratov prolongirovannogo deĭstviia s pomoshch'iu parnykh veloérgometriĭ u bol'nykh so stenokardieĭ.