Effects of TRH-T on spinal motoneurones in man.
The effect of thyrotropin-releasing hormone tartrate (TRH-T) on the decrease in H Max/M Max ratio, an index of the spinal motoneurone pool, induced by haloperidol, was studied in 15 healthy volunteers. In all subjects, the H response was examined by an electromyographic apparatus. The values were expressed as H Max/M Max ratio, that gives an index of excitability of the spinal motoneurone pool. It was found that the mean H Max/M Max ratio value significantly decreased after haloperidol administration, but this effect was completely reversed by the injection of TRH-T. This finding suggests that the peptide may modulate motoneurone functions.
Raffaele
R
R
Institute of Clinical Neurology, University of Catania Medical School, Italy.
Cosentino
E
E
Anicito
M B
MB
Sciacca
A
A
Rampello
L
L
Pennisi
G
G
Genazzani
A A
AA
Bosco
G
G
Casabona
A
A
Drago
F
F
D000328:Adult; D005260:Female; D006181:H-Reflex / Q000187:drug effects; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000187:drug effects*; D013116:Spinal Cord / Q000166:cytology* / Q000187:drug effects; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D013973:Thyrotropin-Releasing Hormone; D006220:Haloperidol