Autoimmune ischemic optic neuropathy associated with positive rheumatoid factor and transient nephrosis.
A young woman had recurrent anterior ischemic optic neuropathy for 18 years. During a recent episode of severe papillopathy in one eye, acute glomerulonephritis, transient low serum complement levels, and a high rheumatoid factor were detected. Despite long and careful follow-up, we could not diagnose systemic lupus erythematosus or any other specific connective tissue or autoimmune disease. We suspect transient disordered immunity may have contributed to provoking acute anterior ischemic optic neuropathy concomitant with acute glomerulonephritis despite the absence of generalized connective tissue disease. An extensive search for immunologic mechanisms in some patients with presumed idiopathic anterior ischemic optic neuropathy may be warranted because immunosuppressive treatment may be beneficial in preventing recurrences.
Coppeto
J R
JR
St. Mary's Hospital, Waterbury, Connecticut.
Greco
T P
TP
D000328:Adult; D001327:Autoimmune Diseases / Q000473:pathology*; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D007511:Ischemia / Q000473:pathology*; D009401:Nephrosis / Q000473:pathology*; D009900:Optic Nerve / Q000098:blood supply*; D010211:Papilledema / Q000473:pathology; D012008:Recurrence; D012217:Rheumatoid Factor / Q000097:blood*; D014794:Visual Fields
D003165:Complement System Proteins; D012217:Rheumatoid Factor