Porcine platelets in vitro and in vivo studies: relevance to human thrombosis research.
This review summarizes present knowledge on porcine platelets in vitro and recent studies on in vivo activation of platelets in the pig. There are certain differences compared to human platelets: Platelet aggregation and secretion cannot be achieved by epinephrine, and the arachidonate pathway seems poorly developed in porcine platelets. Genetic models for von Willebrand disease (vWD) and storage pool deficiency (SPD) have been developed in the pig. Several models for the study of in vivo platelet deposition and early thrombus formation have been developed. Platelet radio-labeling techniques (with 111In) have been used extensively. We conclude that the pig seems to be a good choice for the investigation of in vivo platelet activation and deposition based on present knowledge of porcine platelets and on already established animal models.
Søfteland
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Department of Biochemistry, University of Bergen, Norway.
Framstad
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Thorsen
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Holmsen
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D000800:Angioplasty, Balloon; D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D001807:Blood Vessel Prosthesis; D006801:Humans; D066298:In Vitro Techniques; D008954:Models, Biological; D015539:Platelet Activation; D013552:Swine; D013927:Thrombosis / Q000097:blood*