Pharmacodynamics and pharmacokinetics of cyclosporin A in the newborn pig.
The disposition kinetics of cyclosporin A in the neonates as well as age-related differences in lymphocyte responses to cyclosporin A are unknown. A single intravenous infusion of cyclosporin A was given to neonatal (2.5 or 5 mg/kg) and mature pigs (10 mg/kg) and blood cyclosporin A levels were measured by RIA. The neonates had longer elimination half-life and lower drug clearance than mature animals. Suppression in lymphocyte proliferation was only observed in mixed lymphocyte reaction and phytohemagglutinin-stimulated cultures of the 2-hour samples from neonates receiving 5 mg/kg. We conclude that neonatal pig exhibit different cyclosporin A pharmacokinetics and show higher sensitivity to cyclosporin A than mature animals.
Tsao
P W
PW
Department of Cardiovascular Research, Hospital for Sick Children, Toronto, Canada.
Ito
S
S
Wong
P Y
PY
Radde
I C
IC
Bryson
S
S
Young
D S
DS
Caspi
J
J
Diaz
R J
RJ
Martell
M F
MF
Augustine
J M
JM
D000375:Aging / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D002455:Cell Division; D002478:Cells, Cultured; D016572:Cyclosporine / Q000493:pharmacokinetics* / Q000494:pharmacology*; D007262:Infusions, Intravenous; D008214:Lymphocytes / Q000187:drug effects*; D013552:Swine
D016572:Cyclosporine