title: Formation of a stable 99mTc-tri-hydrazidophosphine oxide (99mTc-THP) chelate.
abstract: Atri-hydrazidophosphine oxide (THP) ligand was synthesized and used to complex 99mTc in high yield (> 95%) by Sn(II) reduction of 99mTcO4-. 99mTc-THP has excellent stability in both 0.9% acqueous NaCl at neutral pH and in human serum at 37 degrees C. Biodistribution studies indicate minimal organ specificity and no significant in vivo release of 99mTcO4-. The ease of 99mTc complexation with THP and the high stability of 99mTc-THP suggests that this ligand may be used as a basis for the development of new imaging agents.
authors: Department of Radiology and Research Reactor, University of Missouri, Columbia.
authors: M
authors: M
authors: Corlija
authors: K V
authors: KV
authors: Katti
authors: W A
authors: WA
authors: Volkert
authors: T J
authors: TJ
authors: Hoffman
authors: C
authors: C
authors: Higginbotham
authors: R A
authors: RA
authors: Holmes
mesh_terms: D000818:Animals; D006801:Humans; D009943:Organophosphorus Compounds / Q000097:blood / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D015609:Organotechnetium Compounds / Q000097:blood / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D010720:Phosphines; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
chemical_list: D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D010720:Phosphines; C079365:technetium Tc 99m trihydrazidophosphine oxide