[Heparin increases platelet aggregation and inhibits fibrinolysis, especially in primary hypertriglyceridemia and after myocardial infarction].
The authors presented the effect of unfractionated heparin on platelet aggregation and fibrinolysis. The studies have been performed in the control group and with primary hypertriglyceridemia as well as in patients after myocardial infarction. Adrenaline and ADP induced platelet aggregation was examined in plasma rich platelets; fibrinolysis was estimated in euglobulin test. These parameters have been determined before and after (10, 20, 60, 240, 360 min.) intravenous injection of 50 units heparin per kg body weight. We have observed, that heparin increased also platelet aggregation and inhibited fibrinolytic activity in persons with primary hypertriglyceridemia particularly and after myocardial infarction. Correlation was found between investigated parameters and products of heparin lipolytic activity, especially with level of free fatty acids.
Jastrzebska
M
M
Zakład Biochemii Klinicznej i Diagnostyki Laboratoryjnej Pomorskiej Akademii Medycznej, Szczecinie.
Chełstowski
K
K
Torbus-Lisiecka
B
B
Pieczul-Mróz
J
J
Wesołowska
T
T
Wira
D
D
D000328:Adult; D000933:Antifibrinolytic Agents; D005342:Fibrinolysis / Q000187:drug effects* / Q000502:physiology; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood*; D000960:Hypolipidemic Agents; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy*; D015539:Platelet Activation / Q000187:drug effects / Q000502:physiology; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology; D014280:Triglycerides / Q000037:antagonists & inhibitors / Q000097:blood*
D000933:Antifibrinolytic Agents; D000960:Hypolipidemic Agents; D014280:Triglycerides; D006493:Heparin
Heparyna nasila agregacje płytek krwi i hamuje fibrynolize szczególnie w hipertrójglicerydemii pierwotnej i po przebytym zawale serca.