Dietary supplementation with fish oil enhances in vivo synthesis of tumor necrosis factor.
Studies reported here investigate the influence of dietary fat types on cytokine production in response to endotoxin (LPS) challenge. Tumor necrosis factor (TNF) serum levels were markedly higher (by 10-fold) in mice fed chronically a diet rich in fish oil rather than either a diet rich in corn or coconut oil or a low fat diet. This in vivo hyper-responsiveness in LPS-induced TNF production following fish oil consumption concorded with similar exaggerated in vitro TNF release from macrophages exposed to LPS. These data suggest that high consumption of fish oils, by virtue of their high content of omega-3 polyunsaturated fatty acids, can lead to an exaggerated production of mediators of inflammation with potentially adverse consequences on the outcome and severity of infectious diseases.
Chang
H R
HR
Department of Genetics and Microbiology, University of Geneva Medical School, Switzerland.
Arsenijevic
D
D
Pechère
J C
JC
Piguet
P F
PF
Mensi
N
N
Girardier
L
L
Dulloo
A G
AG
D000818:Animals; D000074263:Coconut Oil; D003314:Corn Oil / Q000494:pharmacology; D004041:Dietary Fats / Q000494:pharmacology*; D005260:Female; D005395:Fish Oils / Q000494:pharmacology*; D066298:In Vitro Techniques; D008070:Lipopolysaccharides; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D010938:Plant Oils / Q000494:pharmacology; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D004041:Dietary Fats; D005395:Fish Oils; D008070:Lipopolysaccharides; D010938:Plant Oils; D014409:Tumor Necrosis Factor-alpha; D003314:Corn Oil; D000074263:Coconut Oil