Collagen and gelatin-impregnated vascular grafts--is their thrombogenicity enhanced? An experimental study.
The early thrombogenicity of dacron vascular grafts with and without impregnation with collagen (n = 7) or gelatin (n = 7) was evaluated in a sheep carotid artery interposition model. Autologous platelets were labelled with 32P and reinjected. Flow was reduced to 25 ml/min to mimic a situation with poor run-off and the graft thrombogenicity was studied for 4 hours. The results showed no difference as regards patency, thrombus-free surface, or uptake of 32P-labelled platelets between collagen- or gelatin-impregnated grafts and their parent dacron grafts. Thus, no difference in early graft thrombogenicity could be documented.
Jensen
N
N
Department of Surgery, Lund University, Malmö General Hospital, Sweden.
Lindblad
B
B
Dougan
P
P
Bergqvist
D
D
D000818:Animals; D001807:Blood Vessel Prosthesis; D002339:Carotid Arteries / Q000601:surgery; D003094:Collagen; D005260:Female; D005780:Gelatin; D006083:Graft Occlusion, Vascular / Q000097:blood*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology; D011093:Polyethylene Terephthalates; D011474:Prosthesis Design; D012307:Risk Factors; D012756:Sheep
D011093:Polyethylene Terephthalates; D005780:Gelatin; D003094:Collagen