title: High resolution NMR spectroscopy of physiological fluids: from metabolism to physiology.
abstract: High resolution NMR spectroscopy of physiological fluids provides quantitative, qualitative and dynamic information on the metabolic status of the interstitial and plasma compartments under a variety of pathophysiological conditions. The simultaneous detection and quantitation by NMR spectroscopy of numerous compounds of the intermediary metabolism offers a new insight in the understanding of the milieu intérieur. NMR spectroscopy of physiological fluids offers a unique way to define and monitor the global metabolic homeostasis in humans. The development of this analytical approach is still limited by the scarcity of pluridisciplinary teams able to fully exploit the wealth of information present on the NMR spectrum of a fluid. While application in pharmacology and toxicology is already established, the main areas of current development are cancer, hereditary metabolic disorders, organ transplantation and neurological diseases.
authors: Centre de Résonance Magnétique Biologique et Médicale, URA CNRS 1186, Faculté de Médecine, Marseille, France.
authors: J
authors: J
authors: Vion-Dury
authors: F
authors: F
authors: Nicoli
authors: G
authors: G
authors: Torri
authors: J
authors: J
authors: Torri
authors: M
authors: M
authors: Kriat
authors: M
authors: M
authors: Sciaky
authors: A
authors: A
authors: Davin
authors: P
authors: P
authors: Viout
authors: S
authors: S
authors: Confort-Gouny
authors: P J
authors: PJ
authors: Cozzone
mesh_terms: D001826:Body Fluids / Q000378:metabolism* / Q000502:physiology; D002555:Cerebrospinal Fluid / Q000378:metabolism; D006031:Glycosylation; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy