Tracer study of metabolism and tissue distribution of sebacic acid in rats.
The present study investigates the metabolic disposition of sebacic acid in rats. Three groups of experimental animals received different doses of disodium sebacate with 25 microCi of 14C-labeled molecule by intravenous injection. In the first group radioactivity plasma elimination curves were examined for two administered doses (80 and 160 mg). In the second group, expired 14CO2, urine tracer and feces tracer were counted after intravenous administration of 160 mg of sebacate. The animals of the third group were sacrificed at different times after intravenous administration of 160 mg of sebacate, and tracer elimination curves were obtained for several organs. The plasma half-life of sebacate is 38.71 min; about 35% of the administered tracer was excreted in the urine as unchanged sebacate; about 25% was eliminated as 14CO2 in expired air. Disposition of sebacate was complete within 4 h of administration. The sebacate half-life is longest in adipose tissue (135 min) and in liver (74 min), sites of likely transformation. In all other organs examined, the sebacate half-life is similar to that in plasma.
Tataranni
P A
PA
Clinica Medica, Catholic University, Rome, Italy.
Mingrone
G
G
De Gaetano
A
A
Raguso
C
C
Greco
A V
AV
D000042:Absorption; D000818:Animals; D001944:Breath Tests; D002245:Carbon Dioxide / Q000032:analysis; D002250:Carbon Radioisotopes; D003652:Decanoic Acids / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D003998:Dicarboxylic Acids; D005243:Feces / Q000737:chemistry; D006207:Half-Life; D007700:Kinetics; D008297:Male; D009928:Organ Specificity; D051381:Rats; D017208:Rats, Wistar
D002250:Carbon Radioisotopes; D003652:Decanoic Acids; D003998:Dicarboxylic Acids; D002245:Carbon Dioxide; C011107:sebacic acid