Tetracyclines (TETs) inhibit the synthesis and/or activity of cartilage proteinases in vivo and in vitro.
Arsenis
C
C
Ciba-Geigy Research Department, Summit, NJ.
Moak
S A
SA
Greenwald
R A
RA
D000818:Animals; D002358:Cartilage, Articular / Q000201:enzymology*; D017364:Collagenases / Q000096:biosynthesis*; D006132:Growth Plate / Q000201:enzymology*; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology; D019278:Matrix Metalloproteinase 3; D061965:Matrix Metalloproteinase Inhibitors; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D051381:Rats; D011994:Recombinant Proteins / Q000494:pharmacology; D012279:Rickets / Q000201:enzymology*; D013754:Tetracyclines / Q000494:pharmacology*
D007375:Interleukin-1; D061965:Matrix Metalloproteinase Inhibitors; D011994:Recombinant Proteins; D013754:Tetracyclines; D017364:Collagenases; D008666:Metalloendopeptidases; D019278:Matrix Metalloproteinase 3