The vitamin D/parathyroid hormone axis in the pathogenesis of hypertension and insulin resistance in uremia.
Recent evidence suggests a pathogenetic link between hypertension and insulin resistance. In addition, disturbances of vitamin D/parathyroid hormone axis have been reported in various hypertensive and insulin-resistant states. Chronic renal failure is characterized by high incidence of hypertension, insulin resistance and disturbances in the vitamin D/parathyroid hormone axis. Preliminary studies in both patients and rats with end-stage renal disease who were hypertensive, insulin resistant and 1,25-dihydroxycholecalciferol deficient with hyperparathyroidism; parenteral administration of pharmacological doses of 1,25-dihydroxycholecalciferol led to reversal of hypertension and insulin resistance without significant changes in serum calcium or parathyroid hormone concentrations. Thus, vitamin D deficiency may be an important factor in the pathogenesis of hypertension and insulin resistance in end-stage renal disease.
Mak
R H
RH
Department of Pediatrics, Stanford University School of Medicine, Calif. 94305.
Wong
J H
JH
D000818:Animals; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology*; D007333:Insulin Resistance / Q000502:physiology*; D010281:Parathyroid Hormone / Q000502:physiology*; D014511:Uremia / Q000150:complications / Q000503:physiopathology*; D014807:Vitamin D / Q000502:physiology*
D010281:Parathyroid Hormone; D014807:Vitamin D