Comparative effects of endothelin (ET-1) and U46619 on human saphenous vein and gastroepiploic artery, sources of human autologous grafts.
The effects of endothelin (ET-1) on smooth muscle contractile activity were investigated and compared in human saphenous vein and gastroepiploic artery, vessels frequently used in revascularization procedures. ET-1 contracted saphenous vein and gastroepiploic artery in a concentration-dependent manner. The peptide produced a greater maximal effect in the vein than in the artery and, in both preparations, ET-1 was less efficacious than U46619, an agent which mimics the actions of thromboxane A2 at the thromboxane A2/prostaglandin H2 receptor. The contractile response to ET-1 declined spontaneously at a more rapid rate in the artery than in the vein. The present data indicate that ET-1 has significant contractile activity in both vessels which are used for coronary arterial bypass surgery and suggest that although, a weaker vasoconstrictor than U46619, the peptide could induce vasospasm in both graft vessels.
McNamara
D B
DB
Department of Pharmacology, Tulane University School of Medicine, New Orleans, Lousiana 70112.
Light
J T
JT
Minkes
R K
RK
Saroyan
R M
RM
Kvamme
P
P
Rowe
N
N
Webb
W R
WR
Fox
L
L
Kerstein
M D
MD
Mills
N L
NL
D001158:Arteries / Q000187:drug effects / Q000637:transplantation; D004064:Digestive System / Q000098:blood supply*; D016232:Endothelins / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D011450:Prostaglandin Endoperoxides, Synthetic / Q000494:pharmacology*; D012501:Saphenous Vein / Q000187:drug effects* / Q000637:transplantation; D014182:Transplantation, Autologous
D016232:Endothelins; D011450:Prostaglandin Endoperoxides, Synthetic