The influence of C-terminal cholecystokinin fragments in the circulatory system of rats.
The effects of C-terminal unsulfated cholecystokinin octapeptide (CCK-8US) and its fragments C-terminal heptapeptide (CCK-7), C-terminal hexapeptide (CCK-6) and C-terminal pentapeptide (CCK-5) were studied on the arterial blood pressure and the isolated rat heart. CCK-8US had only slight hypertensive and no cardiac effects. CCK-5, CCK-6 and CCK-7 had no effect on the arterial blood pressure, the cardiac contraction amplitude and the heart rate. Only CCK-7 increased coronary outflow of the isolated rat heart. CCK-8US and C-terminal fragments; CCK-7 have little effect on the circulation of the rat.
Wiśniewska
R J
RJ
Department of Pharmacology, Medical Academy, Białystok, Poland.
Kupryszewski
G
G
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012844:Sincalide / Q000494:pharmacology*
D010446:Peptide Fragments; D012844:Sincalide