Integrin expression and adhesion property of osteoclast-like cells from giant cell tumours of bone.
Cells cultured from human giant cell tumours of bone were used to study interactions with different extracellular matrix proteins as Collagen, Fibronectin, Osteocalcin, Thrombospondin and Bone Sialoprotein II. Cells were capable of recognizing these substrata; beta 3 integrin subunit was distributed in focal adhesions, together with beta 1 on BSPII, FN, and in presence of serum, whereas and presented a diffuse organization onto the other substrate. beta 1 alone was expressed over collagen coated coverslips.
Grano
M
M
Istituto di Citomorfologia Normale e Patologica Università di Chieti.
Colucci
S
S
Zigrino
P
P
Serra
M
M
Scotlandi
K
K
Teti
A
A
Zambonin Zallone
A
A
D001859:Bone Neoplasms / Q000378:metabolism*; D002448:Cell Adhesion / Q000502:physiology; D005870:Giant Cell Tumors / Q000378:metabolism*; D006801:Humans; D016023:Integrins / Q000096:biosynthesis*; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D010010:Osteoclasts / Q000378:metabolism* / Q000502:physiology; D014407:Tumor Cells, Cultured
D016023:Integrins; D009363:Neoplasm Proteins