Effects of Phaeodactylum tricornutum and Dunaliella tertiolecta extracts on the central nervous system.
Continuing work on the effects of aqueous extracts of the microalgae Phaeodactylum tricornutum Bohlin (Bacillariophyceae) and Dunaliella tertiolecta Butcher (Chlorophyceae) on the central nervous system, we report their effects on spontaneous motor activity, rectal temperature, exploratory behaviour, muscle relaxation, catalepsy, and conditioned avoidance responses. Both extracts showed activity as a CNS depressant and a potential muscle relaxant, the latter more marked in the case of P. tricornutum.
Villar
R
R
Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, Galicia, Spain.
Laguna
M R
MR
Calleja
J M
JM
Cadavid
I
I
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D017377:Diatoms / Q000737:chemistry*; D008297:Male; D051379:Mice; D051381:Rats; D017207:Rats, Sprague-Dawley