Effects of deltamethrin on the immune system in mice.
The influence of deltamethrin on the immune system in mice was investigated. Female BALB/c mice received deltamethrin in two daily oral doses; 6 mg/kg for 84 days and 15 mg/kg for 14 days. The humoral immune response in animals immunized with sheep red blood cells determined by agglutinin and hemagglutinin titer as well as by the number of plaque-forming cells producing IgM antibodies was significantly decreased. Also, the cell-mediated immune response assessed by alpha-naphthyl acetate esterase activity, by formation of EAC (erythrocyte-antibody-complement) rosettes, and by the footpad reaction test was hindered. A decrease in interleukin-1 activity was also ascertained. The obtained results indicate that deltamethrin exhibits an immunosuppressive effect.
Lukowicz-Ratajczak
J
J
Medical Academy, Department of Toxicology, Gdańsk-Wrzeszcz, Poland.
Krechniak
J
J
D000373:Agglutinins / Q000097:blood; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D005260:Female; D006388:Hemagglutinins / Q000097:blood; D007111:Immunity, Cellular / Q000187:drug effects*; D007306:Insecticides / Q000633:toxicity*; D008198:Lymph Nodes / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D009570:Nitriles; D011722:Pyrethrins / Q000633:toxicity*; D012397:Rosette Formation; D013154:Spleen / Q000187:drug effects / Q000276:immunology
D000373:Agglutinins; D006388:Hemagglutinins; D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; C017180:decamethrin