Maternal immunization by husband's leukocytes for repeated fetal death associated with mild pre-eclampsia--case report with successful outcome.
We report a case of repeated fetal death at 31 gestational weeks associated with mild non-proteinuric pre-eclampsia and intrauterine growth retardation. After double intradermal immunisation with paternal leukocytes, a third pregnancy proceeded uneventfully until it ended at 38 weeks. Maternal anti-paternal blocking antibody activity was assessed by the erythrocyte antibody inhibition (EAI) test. Serologic testing revealed that the couple did not share HLA class I antigens. The mechanisms underlying the likely benefit from immunotherapy are discussed.
Steck
T
T
Department of Obstetrics and Gynecology, University of Würzburg, Federal Republic of Germany.
Westphal
E
E
Würfel
W
W
D000917:Antibody Formation / Q000276:immunology*; D001667:Binding, Competitive; D005260:Female; D005313:Fetal Death / Q000276:immunology*; D005317:Fetal Growth Retardation / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D016219:Immunotherapy, Adoptive; D007231:Infant, Newborn; D017710:Lymphocyte Transfusion; D008214:Lymphocytes / Q000276:immunology; D011225:Pre-Eclampsia / Q000276:immunology*; D011247:Pregnancy
D015395:Histocompatibility Antigens Class I