[Use of cytostatics as anti-cicatricial drugs after anti-glaucoma surgery in children, adolescents and young adults].
Anti-cicatricial cytostatic therapy with 5-fluorouracil and prospidin was carried out after antiglaucoma surgery in 78 eyes of 67 patients aged 6 to 42 (2/3 of the patients were aged from 21 to 40). Half (34) of the patients suffered from open-angle (pigmented in 3 cases) and 6 from closed-angle glaucoma, the rest patients presented with common hydrophthalmia, the Frank-Kamenetsky, Sturdge-Weber, Riger's syndromes, etc. The cytostatics were injected subconjunctivally. The results of 67 surgeries were followed up for 6 months to 3 years. Stable normalization of the ophthalmic tone and stabilization of the process were achieved in 60 eyes (89.2%). The authors emphasize that cytostatics may be recommended for children and young subjects after surgery involving fistulization, on condition of thorough biomicroscopic monitoring in the postoperative period, because of a possible disadaptation of the edges of the mucosal incision and corneal diseases.
Sidorov
E G
EG
Perchikova
O I
OI
Shmyreva
V F
VF
Polutornov
A L
AL
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002921:Cicatrix / Q000209:etiology / Q000517:prevention & control*; D003228:Conjunctiva / Q000187:drug effects; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D005901:Glaucoma / Q000601:surgery*; D006801:Humans; D007267:Injections / Q000379:methods; D008297:Male; D011182:Postoperative Care; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control*; D011447:Prospidium / Q000008:administration & dosage*; D014130:Trabeculectomy / Q000009:adverse effects*
D011447:Prospidium; D005472:Fluorouracil
Primenenie tsitostatikov v kachestve protivorubtsovykh sredstv posle antiglaukomatoznykh operatsiĭ v detskom i molodom vozraste.