Issues in drug-related performance impairment.
Performance impairment associated with alcohol, drugs, and medical disorders is of increasing concern to clinicians. Understanding and assessing performance impairment associated with a particular drug or condition is complex and requires careful, critical evaluation of the literature. Awareness of the issues involved enhances the ability of the clinician to assess risks for a given patient and of a given medical therapy. Important study variables are described that should be considered when evaluating the literature pertaining to performance impairment. The clinical relevance of the results of performance studies is also discussed.
Roth
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Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, Michigan.
Roehrs
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Moskowitz
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D064420:Drug-Related Side Effects and Adverse Reactions; D004812:Epidemiologic Methods; D006801:Humans; D008569:Memory Disorders / Q000139:chemically induced; D011597:Psychomotor Performance / Q000187:drug effects*; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D012890:Sleep / Q000187:drug effects