Xylitol 5-P formation by dental plaque after 12 weeks' exposure to a xylitol/sorbitol containing chewing gum.
Five subjects used xylitol-containing chewing gum for 12 wk. Dental plaque was collected before and after the exposure to xylitol. The plaque samples were examined for their capacity to form xylitol 5-P by incubation with 14C labeled xylitol, extraction and separation on HPLC. It was found that the capacity of the plaque to form xylitol 5-P was not reduced during the xylitol exposure in any of the subjects. No other xylitol-derived metabolites were observed. The inhibitory capacity of xylitol thus appears to be maintained after 12 wk exposure to xylitol.
Wåler
S M
SM
Dental Faculty, University of Oslo, Norway.
Assev
S
S
Rölla
G
G
D000085:Acetates / Q000378:metabolism; D000328:Adult; D002250:Carbon Radioisotopes; D002638:Chewing Gum; D002851:Chromatography, High Pressure Liquid; D003773:Dental Plaque / Q000737:chemistry / Q000378:metabolism*; D005561:Formates / Q000378:metabolism; D006801:Humans; D007773:Lactates / Q000378:metabolism; D010428:Pentosephosphates / Q000032:analysis / Q000378:metabolism*; D013012:Sorbitol / Q000008:administration & dosage; D014993:Xylitol / Q000008:administration & dosage / Q000378:metabolism
D000085:Acetates; D002250:Carbon Radioisotopes; D002638:Chewing Gum; D005561:Formates; D007773:Lactates; D010428:Pentosephosphates; D013012:Sorbitol; C064260:xylitol 5-phosphate; D014993:Xylitol