title: Synthesis of 7-oxo-7H-benzo[e]perimidine-4-carboxamides as potential antitumor drugs.
abstract: A series of 7-oxo-7H-benzo[e]perimidine-4-carboxamides (4a-f) was synthetized from the corresponding acid (3) and the suitable amines by the "mixed anhydride" method. The amide derivatives were tested for antitumor activity against P 388 leukemia "in vivo". Only the N-[2-(diethylamino)ethyl]-7-oxo-7H-benzo[e]perimidine-4-carboxa mid e (4b) shows borderline antineoplastic activity.
authors: Dipartimento di Scienze Chimiche, Università di Camerino, Italy.
authors: I
authors: I
authors: Antonini
authors: P
authors: P
authors: Polucci
authors: D
authors: D
authors: Cola
authors: G
authors: G
authors: Filippo Palmieri
authors: S
authors: S
authors: Martelli
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D008815:Mice, Inbred Strains; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000880:Anthraquinones; D000970:Antineoplastic Agents; D011720:Pyrazoles