title: Effects of hypothyroidism on rat circadian activity and temperature rhythms and their response to light.
abstract: Male rats made hypothyroid by administration of propylthiouracil plus sodium ipodate in drinking water were compared to controls in terms of period of circadian activity and temperature rhythms, amount of gross motor activity, and mean temperature. Animals were studied under entrainment, constant darkness (DD), and constant dim light (LL). There was no difference in the period of the circadian activity rhythm between groups in DD. However, hypothyroid rats showed significant blunting of the period-lengthening response to increasing ambient illumination. As expected, the period of the circadian temperature rhythm increased in controls with increasing ambient illumination. In contrast, the period of the circadian temperature rhythm in hypothyroid animals actually shortened under LL compared to DD. This blunting of the period-lengthening response to increasing ambient illumination of both activity and temperature rhythms in hypothyroid animals could not be explained by differences in activity level or mean temperature between the groups.
authors: Department of Veterans Affairs Medical Center, Providence, RI 02908-4799.
authors: M S
authors: MS
authors: Bauer
authors: A
authors: A
authors: Soloway
authors: M B
authors: MB
authors: Dratman
authors: M
authors: M
authors: Kreider
mesh_terms: D000818:Animals; D001831:Body Temperature; D002940:Circadian Rhythm / Q000502:physiology*; D007037:Hypothyroidism / Q000139:chemically induced / Q000503:physiopathology*; D007487:Ipodate; D008029:Lighting; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D011441:Propylthiouracil; D051381:Rats; D011919:Rats, Inbred Strains; D017207:Rats, Sprague-Dawley; D013963:Thyroid Hormones / Q000502:physiology
chemical_list: D013963:Thyroid Hormones; D011441:Propylthiouracil; D007487:Ipodate