[Activation of the processes of lipid peroxidation in the small-intestinal mucosa and liver in peritonitis and possible ways of their correction by a complex infusion-detoxification therapy].
Possibilities of lipid peroxidation (LPO) correction by infusion-detoxication therapy in peritonitis were studied in an experiment on 160 white rats and during clinical treatment of 88 patients with general peritonitis. It was shown that peritonitis development in rats was attended by an increase of LPO products--malonic dialdehyde and diene conjugates, in the hepatic tissue and small intestine mucosa, while the activity of antioxidant defense elements--superoxide dismutase and fat-soluble antioxidants, decreased. It was noted that LPO became normal after intravenous administration of exogenous superoxide dismutase (6 mg/kg) and the blood substitute Mafusol containing Krebs cycle substrate--sodium fumarate (9 ml/kg). Inclusion of Mafusol into the combined therapy of patients with general peritonitis contributed to the reduction of malonic dialdehyde and diene conjugate levels in the blood, normalization of its acid-base state, diminution of medium mass molecule content. Similar normalization of LPO was not recorded when lactosol was used. It has been concluded that blood substitute Mafusol used in the combined therapy of patients with general peritonitis significantly raises the treatment effectiveness.
Selivanov
E A
EA
Khanevich
M D
MD
Starokon'
P M
PM
Slepneva
L V
LV
Zybina
N N
NN
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D005561:Formates / Q000008:administration & dosage*; D006801:Humans; D007262:Infusions, Intravenous; D007413:Intestinal Mucosa / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D007421:Intestine, Small / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D007773:Lactates / Q000008:administration & dosage*; D019344:Lactic Acid; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D010538:Peritonitis / Q000188:drug therapy / Q000201:enzymology / Q000378:metabolism*; D051381:Rats; D013482:Superoxide Dismutase / Q000008:administration & dosage / Q000172:deficiency*
D000975:Antioxidants; D005561:Formates; D007773:Lactates; C030544:formic acid; D019344:Lactic Acid; D013482:Superoxide Dismutase
Aktivatsiia protsessov perekisnogo okisleniia lipidov v slizistoĭ tonkoĭ kishki i pecheni pri peritonite i vozmozhnye puti ikh korrektsii kompleksnoĭ infuzionno-detoksikatsionnoĭ terapieĭ.