Conformation of cyclosporin A in polar solvents.
A major conformation of cyclosporin A in methanol and in aqueous methanol was revealed by some simple NMR experiments. Thus, a stepwise transition of cyclosporin A conformation from 100% CDCl3 to 100% CD3OD was followed by 1H NMR, which showed that the chloroform conformation of cyclosporin A was still the major one in methanol. Employing the same technique, it was also shown that the chloroform conformation of cyclosporin A was one of the major conformations in 50% aqueous methanol. This may be the first experimental determination of a major conformation of cyclosporin A in polar solvents.
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Preclinical Research, Sandoz Pharma AG, Basel, Switzerland.
Dalvit
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D000595:Amino Acid Sequence; D016572:Cyclosporine / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol / Q000737:chemistry; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D012997:Solvents / Q000737:chemistry; D014867:Water / Q000737:chemistry
D012997:Solvents; D014867:Water; D016572:Cyclosporine; D000432:Methanol