title: [Zinc content in pancreatic islets in experimental diabetes induced by chelating agents].
abstract: The zinc content in microresected islets of rabbits, mice, rats, and guinea pigs was determined by atom-absorption spectrophotometry. The content was found to be highest in rabbits, and diabetes was induced in them by chelating agents easily. Injection of dithizone or 8-(p-toluenesulfonylamine) quinoline failed to induce diabetes mellitus in mice, rats, and guinea pigs. It is concluded that diabetogenic chelating agents are capable of producing irreversible diabetogenic affection in those beta-cells which contain a critical concentration of reactant zinc.
authors: Z E
authors: ZE
authors: Bavel'skiĭ
authors: T V
authors: TV
authors: Zaviazkina
authors: Iu S
authors: IuS
authors: Moiseev
authors: V I
authors: VI
authors: Medvedev
mesh_terms: D000818:Animals; D002614:Chelating Agents; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced* / Q000378:metabolism; D005260:Female; D006168:Guinea Pigs; D007515:Islets of Langerhans / Q000378:metabolism*; D008297:Male; D051379:Mice; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D015032:Zinc / Q000378:metabolism*
chemical_list: D002614:Chelating Agents; D015032:Zinc
vernacular_title: Soderzhanie tsinka v pankreaticheskikh ostrovkakh i éksperimental'nyĭ diabet, vyzyvaemyĭ khelatoobrazovateliami.