Lymphatic targeting of polymeric nanoparticles after intraperitoneal administration in rats.
Following intraperitoneal administration, the lymphatic targeting of polyacrylic nanoparticles has been evaluated in thoracic duct cannulated rats. The dosage forms administered consisted of carbon-14 polyhexylcyanoacrylate nanoparticles (PHCA) and polymethylmethacrylate (PMMA) nanoparticles. The carbon-14 concentrations were much higher in the excreted thoracic lymph than in the blood for both types of particles. The most dramatic results were found in the mediastinal nodes since the carbon-14 concentrations of rats receiving PHCA and PMMA nanoparticles by the ip route were 70- to more than 2000-fold higher than in the corresponding nodes of animals treated by the intravenous route. This potential lymphatic targeting could prove valuable in cancerology to treat tumors that metastasize in the peritoneal cavity or via lymphatic pathways such as colon carcinomas.
Maincent
P
P
Laboratoire de Pharmacie galénique et Biopharmacie, Faculté des Sciences Pharmaceutiques et Biologiques, Nancy, France.
Thouvenot
P
P
Amicabile
C
C
Hoffman
M
M
Kreuter
J
J
Couvreur
P
P
Devissaguet
J P
JP
D000818:Animals; D007274:Injections, Intraperitoneal; D008196:Lymph / Q000378:metabolism; D008208:Lymphatic System / Q000502:physiology*; D008297:Male; D008768:Methylmethacrylates; D008854:Microscopy, Electron; D008863:Microspheres; D010316:Particle Size; D010529:Peritoneal Cavity / Q000166:cytology; D011108:Polymers; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
D008768:Methylmethacrylates; D011108:Polymers