[Renin-angiotensin system].
Renin is a key enzyme in the renin-angiotensin system (RAS) which controls the blood pressure and electrolyte balance. By numerous studies on RAS and structures of renin and prorenin, the determination of three-dimensional structure for renin has been thought to be important in the rational approach to the drug design for antihypertensives. Here, several investigations for the three-dimensional structure of human and mouse renins are reviewed. These papers showed that the active site cleft had a less open arrangement in renins than that in other aspartic proteinases, although the general topology of both renins were quite similar. They also described subsites of renins and others.
Suzuki
F
F
Department of Biotechnology, Faculty of Agriculture, Gifu University.
D000595:Amino Acid Sequence; D000818:Animals; D004792:Enzyme Precursors / Q000737:chemistry / Q000502:physiology; D006801:Humans; D051379:Mice; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D051381:Rats; D012083:Renin / Q000737:chemistry / Q000502:physiology; D012084:Renin-Angiotensin System
D004792:Enzyme Precursors; D012083:Renin