Phenotype of lymphocyte in ovarian tumor peritoneal fluid. A preliminary study.
Phenotype of lymphocytes was estimated in 16 peritoneal fluids obtained from 9 ovarian cancer patients. Peritoneal fluids contained predominantly T cells (more than 80%) while B cell content was relatively low. Approximately 50% lymphocytes carried T-helper cell marker (CD4). Percentage of T-cytotoxic/suppressor cells (CD8+ cells) differed between patients with progression and those showing no tumor progression (19.0 +/- 7.5 vs 32.7 +/- 18.5). CD4/CD8 ratio was higher in the group of patients with progression than in the group with no progression of the tumor (3.4 +/- 2.1 and 2.0 +/- 1.5). Chemotherapy did not affect the parameters. Estimation of CD8 and CD4/CD8 ratio in peritoneal fluid cells could be helpful in monitoring of disease progression.
Lacki
J
J
Cell. Immunol. Lab., University School of Medicine, Poznan.
Markowska
J
J
Wiktorowicz
K
K
D000328:Adult; D000368:Aged; D001202:Ascitic Fluid / Q000276:immunology* / Q000473:pathology; D001402:B-Lymphocytes; D016516:CD4-CD8 Ratio; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes / Q000166:cytology*; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000276:immunology* / Q000473:pathology; D010641:Phenotype; D013601:T-Lymphocytes; D006377:T-Lymphocytes, Helper-Inducer