Alfentanil infusion in total intravenous anaesthesia (TIVA). Population pharmacokinetics fails to predict plasma concentration of alfentanil.
In order to evaluate the ability to predict plasma concentrations from population-corrected pharmacokinetics, a prospective study comprising 14 women admitted for elective hysterectomy was done. Alfentanil was given in combination with propofol in a total intravenous anaesthesia technique. The predicted median alfentanil concentration (289(256-363) ng ml-1) was significantly lower than the measured median plasma concentration of 368(168-666) ng ml-1). In conclusion, population-based pharmacokinetics were found not to be accurate as they underestimate plasma concentrations of alfentanil.
Jenstrup
M
M
Department of Anaesthesiology, Central Hospital, Hillerød, Denmark.
Fruergård
K
K
Nielsen
J
J
Møller
A M
AM
Wiberg-Jørgensen
F
F
D015760:Alfentanil / Q000097:blood* / Q000493:pharmacokinetics*; D000771:Anesthesia, Intravenous; D016001:Confidence Intervals; D005260:Female; D005544:Forecasting; D006801:Humans; D015742:Propofol / Q000008:administration & dosage; D011446:Prospective Studies; D013997:Time Factors
D015760:Alfentanil; D015742:Propofol