Influence of melatonin on the proliferation of hepatoma cells in the Syrian hamster: in vivo and in vitro study.
A study was carried out to determine the possible influence of melatonin on the proliferation of Kirkman-Robbins hepatoma cells in Syrian hamsters, both in vivo and in vitro. A highly significant inhibition of the proliferation of transplanted hepatoma cells was observed in vivo following melatonin administration (proliferation index 10.3 +/- 1.5; mean +/- SD) in comparison with controls (proliferation index 23.3 +/- 2.2), whereas in vitro melatonin (at concentrations of 10(-5)-10(-11) M) was ineffective. These results indicate that inhibitory effect of melatonin on transplantable hepatoma cells in vivo may be indirect.
Karasek
M
M
Department of Pathological Anatomy, Medical University, Lodz, Poland.
Liberski
P
P
Kunert-Radek
J
J
Bartkowiak
J
J
D000818:Animals; D001973:Bromodeoxyuridine / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D006224:Cricetinae; D004261:DNA Replication / Q000187:drug effects; D066298:In Vitro Techniques; D007279:Injections, Subcutaneous; D008114:Liver Neoplasms, Experimental / Q000473:pathology*; D008297:Male; D008550:Melatonin / Q000008:administration & dosage / Q000494:pharmacology*; D008647:Mesocricetus; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured
D001973:Bromodeoxyuridine; D008550:Melatonin