title: Analgesic and hypnosis potentiation effect of some 1-(2-benzothiazolyl)-1-aryl-3-phenyl-4-aryl guanidines.
abstract: 1-(2-benzothiazolyl)-1-aryl-3-phenyl-4-arylguanidines (I-X) were prepared by oxidation of 1,3-diarylthioureas. The compounds were screened for their analgesic and hypnotic activities in rats. Of these, p-methyl group substituted compound of the series was the most potent analgesic as compared to other compounds of the series. In hypnotic test all the compounds potentiated pentobarbitone-induced hypnosis.
authors: Department of Pharmaceutics, Banaras Hindu University, Varanasi, India.
authors: N
authors: N
authors: Siddiqui
authors: S N
authors: SN
authors: Pandeya
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D005260:Female; D006146:Guanidines / Q000737:chemistry / Q000494:pharmacology*; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
chemical_list: D000700:Analgesics; D006146:Guanidines; D006993:Hypnotics and Sedatives