Transfer of bilirubin covalently bound to 125I-albumin from blood to brain in the Gunn rat newborn.
Transfer of bilirubin covalently bound to albumin (Alb.B) from blood into brain was examined in Gunn rats at postnatal day 3, 7, 14, 28 or 70. The ratio of the 125I-Alb.B concentration in the brain to that in the plasma 2 h after the injection (RAB) was used as a criterion for Alb.B transfer. RAB in brain decreased with age until day 28. Significant correlations were indicated between 125I-Alb.B plasma levels and those in the brain at days 7 and 14, but not at day 28. These results suggested that 125I-Alb.B could transfer from the blood to the brain until day 14. Comparison of the relative amount of radioactivity accumulated in the brain by a 125I-Alb.B injection with that of 125I-albumin alone revealed higher radioactivity in the former than the latter only at day 14, suggesting a transient appearance of particular cellular elements with high affinity to bilirubin in the developmental stage of the brain.
Ohsugi
M
M
Department of Anatomy, Mie University, School of Medicine, Japan.
Sato
H
H
Yamamura
H
H
D000375:Aging / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001663:Bilirubin / Q000097:blood / Q000378:metabolism*; D001921:Brain / Q000254:growth & development* / Q000378:metabolism*; D002531:Cerebellum / Q000254:growth & development / Q000378:metabolism; D005260:Female; D007700:Kinetics; D008297:Male; D051381:Rats; D011911:Rats, Gunn; D012711:Serum Albumin, Radio-Iodinated / Q000378:metabolism*
D012711:Serum Albumin, Radio-Iodinated; D001663:Bilirubin