How bacterial protein toxins enter cells; the role of partial unfolding in membrane translocation.
Bacterial protein toxins translocate across membranes by processes that are still mysterious. Studies on diphtheria toxin have shown that partial unfolding processes play a major role in toxin membrane insertion and translocation. Similar unfolding behaviour is seen with other bacterial toxins. The lessons gained from this behaviour allow us to propose novel mechanisms for toxin translocation.
London
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Department of Biochemistry and Cell Biology, State University of New York, Stony Brook 11794-5215.
D001426:Bacterial Proteins / Q000378:metabolism*; D001427:Bacterial Toxins / Q000737:chemistry / Q000378:metabolism*; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002772:Cholera Toxin / Q000737:chemistry / Q000378:metabolism; D004167:Diphtheria Toxin / Q000737:chemistry / Q000378:metabolism; D004705:Endocytosis; D004768:Enterotoxins / Q000737:chemistry / Q000378:metabolism; D029968:Escherichia coli Proteins; D006680:HLA Antigens / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008567:Membranes, Artificial; D008958:Models, Molecular; D011487:Protein Conformation
D001426:Bacterial Proteins; D001427:Bacterial Toxins; D004167:Diphtheria Toxin; D004768:Enterotoxins; D029968:Escherichia coli Proteins; D006680:HLA Antigens; D008567:Membranes, Artificial; D002772:Cholera Toxin; C027538:heat-labile enterotoxin, E coli