Changes in food intake and forestomach motility of dwarf goats by recombinant bovine cytokines (IL-1 beta, IL-2) and IFN-gamma.
The present study was carried out to investigate the effects of rboIL-1 beta, rboIL-2, and rboIFN-gamma on food intake and forestomach motility in conscious dwarf goats. The intravenous injection of rboIL-1 beta (1 micrograms kg-1) resulted in tachycardia and an immediate fever that reached peak values 45 and 180 min after injection. At 9 to 13 min after rboIL-1 beta administration, both frequency and amplitude of rumen contractions rapidly diminished, being minimal at 30 min; during the fever, all goats refused to eat. Compared with the fever induced by rboIL-1 beta, that caused by rboIFN-gamma (2 micrograms kg-1 IV) was delayed in onset. Although the biphasic fever after rboIFN-gamma was more pronounced than after rboIL-1 beta, the changes in forestomach motility, food intake, and heart rate were less than after rboIL-1 beta. No changes in rectal temperature, heart rate, forestomach motility, and food intake were observed after rboIL-2 (1 micrograms kg-1 IV) injection. These results strongly indicate that the effects of cytokines on body temperature can be dissociated from their effects on food intake. Furthermore, these data suggest a possible relationship between forestomach motility and food intake.
van Miert
A S
AS
Department of Veterinary Basic Sciences, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
Kaya
F
F
van Duin
C T
CT
D000818:Animals; D001831:Body Temperature / Q000502:physiology; D002417:Cattle; D003864:Depression, Chemical; D004435:Eating / Q000187:drug effects*; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006041:Goats; D006339:Heart Rate / Q000187:drug effects; D007371:Interferon-gamma / Q000494:pharmacology*; D007375:Interleukin-1 / Q000494:pharmacology*; D007376:Interleukin-2 / Q000494:pharmacology*; D008297:Male; D011994:Recombinant Proteins / Q000494:pharmacology; D012417:Rumen / Q000187:drug effects*
D007375:Interleukin-1; D007376:Interleukin-2; D011994:Recombinant Proteins; D007371:Interferon-gamma