[A spectral analysis of the effect of sidnocarb on the bioelectrical activity of the rat brain].
A quantitative pharmaco-EEG analysis of the action of psychostimulant drug sydnocarb and its solvent polyethylenglycol-400 on bioelectrical activity of sensomotor cortex, dorsal hippocamp and lateral hypothalamus of wakeful rats in free behavior was carried out. Polyethylenglycol-400 proved to affect CNS, as it decreases slow-wave activity and causes displacement of the dominant peak to the region of more slow-wave frequencies, shows anticonvulsant action. Sydnocarb reduces absolute power of all frequency ranges and increases relative power of fast activity. It is concluded that sydnocarb increases in optimal limits the level of CNS vigilance which may underlie a psychostimulant action of the drug eventuating into optimization of behavioral functions, increasing physical and mental capacity for work.
Krapivin
S V
SV
Sergeeva
S A
SA
Khafiz'ianova
R Kh
RKh
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000187:drug effects / Q000379:methods; D005583:Fourier Analysis; D008297:Male; D011092:Polyethylene Glycols / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D012996:Solutions; D013558:Sydnones / Q000494:pharmacology*; D014851:Wakefulness / Q000187:drug effects / Q000502:physiology
D011619:Psychotropic Drugs; D012996:Solutions; D013558:Sydnones; D011092:Polyethylene Glycols; C009257:sidnocarb
Spektral'nyĭ analiz vliianiia sidnokarba na bioélektricheskuiu aktivnost' mozga krys.