title: Bucillamine (a new therapeutic agent for rheumatoid arthritis) induced nephrotic syndrome: a report of two cases and review of the literature.
abstract: Two cases of nephrotic syndrome during bucillamine treatment were encountered in 1989 in our hospital; both patients had suffered from rheumatoid arthritis for 2 years. They had received 200 mg bucillamine orally per day for 3-4 months before the onset of the nephrotic syndrome. Discontinuation of bucillamine led to complete remission of the nephrotic syndrome within 1 year. Bucillamine is a new therapeutic agent for rheumatoid arthritis developed in 1982 in Japan. Since 1985, 14 cases of nephrotic syndrome, including the two cases reported here have been reported. We review these cases and discuss the pathogenesis.
authors: Department of Medicine, Hamamatsu University School of Medicine.
authors: T
authors: T
authors: Isozaki
authors: M
authors: M
authors: Kimura
authors: N
authors: N
authors: Ikegaya
authors: T
authors: T
authors: Arai
authors: Y
authors: Y
authors: Fujigaki
authors: A
authors: A
authors: Hishida
authors: E
authors: E
authors: Kaneko
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy*; D003545:Cysteine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000139:chemically induced*; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000009:adverse effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013438:Sulfhydryl Compounds; D003545:Cysteine; C026535:bucillamine