Clinical and metabolic effects of a triphasic pill containing gestodene.
The clinical and metabolic effects of a low-dose triphasic oral contraceptive containing gestodene were investigated in 42 healthy women during 6 months of treatment. No pregnancies and no severe side effects occurred during the study. The pill exerted good cycle control and the incidence of irregular bleeding was very low. As for the coagulatory system, there was an increase in prothrombin activity and in fibrinopeptide A plasma levels, and a decrease in activated partial thromboplastin time. Antithrombin III activity, fibrinogen concentration and platelets count did not change during pill intake. No significant modifications in plasma total-cholesterol, low density lipoprotein-cholesterol or in the subfraction high density lipoprotein2-cholesterol (HDL2-CH) were observed. Serum triglycerides, HDL-CH and HDL3-CH levels were significantly higher at the end of treatment. The pill did not alter fasting insulin and glucose levels or their response to an oral glucose tolerance test. These minimal effects on metabolism, combined with its high efficacy and acceptability, may suggest that this triphasic formulation with gestodene seems to be a safe and reliable contraceptive agent.
Fruzzetti
F
F
Department of Obstetrics and Gynecology, University of Pisa, Italy.
Ricci
C
C
Nicoletti
I
I
Fioretti
P
P
D000328:Adult; D001774:Blood Chemical Analysis; D001777:Blood Coagulation / Q000187:drug effects; D002241:Carbohydrates / Q000097:blood; D003276:Contraceptives, Oral / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008597:Menstrual Cycle / Q000187:drug effects; D009652:Norpregnenes / Q000494:pharmacology*
D002241:Carbohydrates; D003276:Contraceptives, Oral; D008055:Lipids; D009652:Norpregnenes; C033273:Gestodene