Paroxysmal nocturnal haemoglobinuria in Indians.
Paroxysmal nocturnal haemoglobinuria (PNH) was diagnosed in 11 patients attending the haematology clinic of a private community hospital in Hyderabad, India over a 3-year period. Compared to PNH occurring in Caucasians, the patients were younger, and showed a marked male preponderance; severe thrombocytopenia, haemorrhagic complications from thrombocytopenia and infectious complications were not seen. Thrombotic complications were common. Fever during periods of haemoglobinuria was a notable feature in 4 patients. None of the patients had the aplastic anaemia PNH syndrome.
Koduri
P R
PR
Department of Haematology-Oncology, Apollo Hospitals, Hyderabad, India.
Gowrishankar
S
S
D000293:Adolescent; D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D004912:Erythrocytes / Q000473:pathology; D005260:Female; D006457:Hemoglobinuria, Paroxysmal / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D007194:India; D008297:Male; D011247:Pregnancy; D012737:Sex Factors; D013927:Thrombosis / Q000209:etiology