title: Occurrence of melanoma in "dysplastic" nevus spilus: report of case and analysis by flow cytometry.
abstract: We report a case of melanoma arising in a large nevus spilus. On histologic examination, the nevus spilus had diagnostic features of melanocytic dysplasia. Further characterization by flow cytometry showed DNA-aneuploidy within the melanoma as well as in one of the darker pigmented papules within the nevus spilus. The significance of this finding and a review of melanomas originating in nevi spili are presented.
authors: Pathology Department, Massachusetts General Hospital, Harvard Medical School, Boston.
authors: R S
authors: RS
authors: Kurban
authors: F I
authors: FI
authors: Preffer
authors: A J
authors: AJ
authors: Sober
authors: M C
authors: MC
authors: Mihm
authors: R L
authors: RL
authors: Barnhill
mesh_terms: D000328:Adult; D000368:Aged; D004416:Dysplastic Nevus Syndrome / Q000150:complications* / Q000473:pathology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008545:Melanoma / Q000150:complications* / Q000473:pathology*; D008875:Middle Aged; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology*