Correlation in ages at death from familial ovarian cancer among sisters.
The analysis of pedigrees taken from 97 of 1466 women attending a screening clinic for early familial ovarian cancer showed that there was a strong correlation in the ages at death from the disease among sisters (r = 0.68, confidence limits 0.51-0.82, P < 0.001), but not between mothers and daughters. This information can be used to help counsel women who are considering the appropriate time for more intensive screening or prophylactic oophorectomy.
Houlston
R S
RS
Department of Clinical Genetics, Royal Free Hospital School of Medicine, London, United Kingdom.
Hampson
J
J
Collins
W P
WP
Whitehead
M I
MI
Campbell
S
S
Slack
J
J
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000401:mortality*; D010375:Pedigree