Insertional mutation of 'classical' and novel genes in transgenic mice.
Approximately 5% of established transgenic lines carry insertional mutations. The mutated genes may be directly isolated using the transgene DNA as a molecular probe. These mutants provide useful models of human inherited disorders and developmental abnormalities.
Meisler
M H
MH
Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109-0618.
D000818:Animals; D005260:Female; D008297:Male; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics*; D016254:Mutagenesis, Insertional; D010641:Phenotype