APHE-1 and APHE-2, two new antimicrobial and cytotoxic antibiotics. I. Taxonomy, fermentation, isolation and biological activity.
APHE-1 and APHE-2 are two new antibiotics produced by Streptoverticillium griseocarneum NCIMB 40447. They exhibited a remarkable cytotoxic activity against several tumor cell lines from different origin. Furthermore, they showed weak antimicrobial activity against Gram-positive bacteria, filamentous fungi and yeasts.
Fidalgo
M L
ML
Departamento de Microbiología y Parasitología, Universidad de Alcalá de Henares, Madrid, Spain.
Alonso
J L
JL
Soliveri
J
J
Arias
M E
ME
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004273:DNA, Neoplasm / Q000096:biosynthesis; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007546:Isoquinolines / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D007700:Kinetics; D051379:Mice; D011720:Pyrazoles / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D013306:Streptomycetaceae / Q000145:classification / Q000254:growth & development / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D004273:DNA, Neoplasm; D007546:Isoquinolines; D011720:Pyrazoles; C078848:antibiotic APHE 1; C078851:antibiotic APHE 2