Therapy of alopecia areata with diphencyprone.
The properties of diphencyprone (DPC), its possible mechanism of action in the therapy of alopecia areata (AA), and its side-effects are summarized. The results of our own study of treatment in 45 patients with AA, with a mean treatment duration of 72 (15-146) weeks, are presented, and compared with the results of previous studies. We suggest that, in future, therapy protocols should define entry criteria and therapy results more precisely, and include follow-up assessments to establish the length of remission. In view of the low response rates and short lengths of remission, the indications for DPC therapy should be set more rigorously.
Hoting
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E
Department of Dermatology, University Clinic Hamburg-Eppendorf, Germany.
Boehm
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A
D000293:Adolescent; D000328:Adult; D000506:Alopecia Areata / Q000188:drug therapy*; D003521:Cyclopropanes / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012074:Remission Induction
D003521:Cyclopropanes; C029402:diphenylcyclopropenone