[In vitro transfer of immunity against PPD with dialyzable extract of leukocytes from human colostrum].
The aim of this study is to demonstrate the transference of PPD hypersensibility in an in vitro model, with dialysable colostral leukocyte extract (DCLE) of PPD+ and PPD-mothers, through measurements of leukocyte migration inhibition factor activity (LIF) from blood obtained of the umbilical cord of newborns from PPD+ mothers. The results show that DCLE PPD+ incubated with leukocytes of newborns from PPD- mothers had inhibition of leukocyte migration compared with migration of leukocytes incubated with DCLE PPD-. These results suggest that in this in vitro model, DCLE transfers hypersensibility to PPD.
Martínez-Cairo Cueto
S
S
Departamento de inmunología, Hospital de Pediatría, México, DF.
Alasio-Chávez
C
C
Dávila Velázquez
J R
JR
D000328:Adult; D002457:Cell Extracts / Q000276:immunology*; D002478:Cells, Cultured; D003126:Colostrum / Q000276:immunology*; D005260:Female; D006801:Humans; D007112:Immunity, Maternally-Acquired / Q000276:immunology*; D007231:Infant, Newborn; D007961:Leukocyte Migration-Inhibitory Factors / Q000276:immunology; D007962:Leukocytes / Q000276:immunology*; D011247:Pregnancy; D014373:Tuberculin / Q000276:immunology*
D002457:Cell Extracts; D007961:Leukocyte Migration-Inhibitory Factors; D014373:Tuberculin
Transferencia in vitro de inmunidad a PPD con extracto dializable de leucocitos de calostro humano.