title: Bradycardia during reversible hypovolaemic shock: associated neural reflex mechanisms and clinical implications.
abstract: 1. Heart rate response to reversible central hypovolaemia can be divided into three stages. In the first stage (corresponding to a reduction of the blood volume by approximately 15%) a modest increase in heart rate (< 100 beats/min) and total peripheral resistance compensate for the blood loss, and a near normal arterial blood pressure prevails (preshock). During the second stage, a reduction of the central blood volume by approximately 30% results in a decrease in heart rate, total peripheral resistance and blood pressure due to activation of unmyelinated vagal afferents (C-fibres) from the left ventricle. In the third stage, blood pressure falls further as haemorrhage continues and tachycardia (> 120 beats/min) is manifest. This stage may proceed into irreversible shock with death from cardiac arrest probably related to the formation of free oxygen radicals. 2. Recognition of the vasodepressor-cardioinhibitory reaction to a reduced circulating blood volume is important and suggests the need for immediate treatment with volume expansion in critically ill patients.
authors: Department of Anaesthesia, Rigshospitalet 2034, University of Copenhagen, Denmark.
authors: N H
authors: NH
authors: Secher
authors: J
authors: J
authors: Jacobsen
authors: D B
authors: DB
authors: Friedman
authors: S
authors: S
authors: Matzen
mesh_terms: D001341:Autonomic Nervous System / Q000503:physiopathology*; D001919:Bradycardia / Q000209:etiology*; D006321:Heart / Q000294:innervation; D006801:Humans; D008955:Models, Cardiovascular; D012018:Reflex / Q000502:physiology*; D012769:Shock / Q000150:complications* / Q000503:physiopathology