Non-peptide fibrinogen receptor antagonists. 1. Discovery and design of exosite inhibitors.
Hartman
G D
GD
Merck Research Laboratories, Department of Medicinal Chemistry, West Point, Pennsylvania 19486.
Egbertson
M S
MS
Halczenko
W
W
Laswell
W L
WL
Duggan
M E
ME
Smith
R L
RL
Naylor
A M
AM
Manno
P D
PD
Lynch
R J
RJ
Zhang
G
G
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000595:Amino Acid Sequence; D001665:Binding Sites; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009842:Oligopeptides / Q000494:pharmacology; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D010980:Platelet Membrane Glycoproteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000077466:Tirofiban; D014443:Tyrosine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D014471:Umbilical Veins
D009842:Oligopeptides; D010975:Platelet Aggregation Inhibitors; D010980:Platelet Membrane Glycoproteins; D014443:Tyrosine; D000244:Adenosine Diphosphate; D005340:Fibrinogen; D000077466:Tirofiban