Noninflammatory bullae associated with epsilon-aminocaproic acid infusion.
Three patients who had cardiac surgery developed a transient, noninflammatory subepidermal bullous eruption on the legs after epsilon-aminocaproic acid infusion. Fibrin thrombi were demonstrated in papillary dermal vessels. The use of epsilon-aminocaproic acid as an antifibrinolytic agent may predispose patients to cutaneous vascular thromboses.
Brooke
C P
CP
Department of Dermatology, University of Alabama, Birmingham.
Spiers
E M
EM
Omura
E F
EF
D000328:Adult; D000368:Aged; D015119:Aminocaproic Acid / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D007868:Leg Dermatoses / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000473:pathology
D015119:Aminocaproic Acid