Addition of long-chain polyunsaturated fatty acids to formula for very low birth weight infants.
Thirty-four premature infants who were appropriate for gestational age and weighing less than 1500 g at birth were fed "preemie" SMA-24 formula, "preemie" SMA-24 formula manufactured to contain C20 and C22 omega 6 and omega 3 fatty acids (LCPE-SMA), or expressed milk (EBM). Blood samples were drawn from a small arm vein during the first week of life and after 28 days of feeding. The fatty acid content of plasma phospholipids was determined. Infants fed SMA-24 had a high content of 18:2 omega 6 in plasma phospholipids. Feeding LCPE-SMA normalized plasma phospholipid levels of C20 and C22 omega 6 and omega 3 fatty acids to be similar to levels of C20 and C22 omega 6 and omega 3 fatty acids found in infants fed EBM, and significantly higher than characteristic levels for infants fed SMA-24. Feeding LCPE-SMA or EBM results in a balanced incorporation of C20 and C22 omega 6 and omega 3 fatty acids into phospholipids derived from the liver or perhaps the small intestine.
Clandinin
M T
MT
Department of Foods and Nutrition, University of Alberta, Edmonton, Canada.
Garg
M L
ML
Parrott
A
A
Van Aerde
J
J
Hervada
A
A
Lien
E
E
D005227:Fatty Acids / Q000097:blood; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D006801:Humans; D007225:Infant Food; D007227:Infant Nutritional Physiological Phenomena; D007230:Infant, Low Birth Weight / Q000097:blood / Q000254:growth & development; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood / Q000254:growth & development; D008895:Milk, Human; D010743:Phospholipids / Q000097:blood; D015430:Weight Gain
D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D010743:Phospholipids