Long-term regulation of pancreatic B-cell responsiveness to D-glucose by food availability, feeding schedule, and diet composition.
The immediate metabolic, cationic, and secretory response of the insulin-producing B-cell to D-glucose is regulated, in a delayed or long-term manner, by nutritional factors such as food availability, feeding schedule, or diet composition. The B-cell keeps the memory of these nutritional manipulations so that the corresponding changes in its responsiveness to D-glucose can be documented in vitro in isolated pancreatic islets. The results of experiments conducted in starved rats, in animals exposed to an altered feeding schedule, and in rats given free access to a high-carbohydrate, high-protein, or high-lipid, as distinct from balanced, diet all suggest that a sufficient prandial hyperglycemia is essential for maintenance of an optimal metabolic and secretory behavior of the islet B-cell in response to a rise in D-glucose concentration.
Carpinelli
A R
AR
Department of Physiology and Biophysics, University of Sao Paulo, Brazil.
Curi
R
R
Malaisse
W J
WJ
D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology; D004040:Dietary Carbohydrates / Q000378:metabolism; D004041:Dietary Fats / Q000378:metabolism; D004044:Dietary Proteins / Q000378:metabolism; D005247:Feeding Behavior / Q000502:physiology*; D005508:Food Deprivation / Q000502:physiology; D006815:Hunger / Q000502:physiology*; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000502:physiology*; D051381:Rats
D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D007328:Insulin