title: Analysis of the 14;18 translocation in cutaneous lymphomas using the polymerase chain reaction.
abstract: A series of 25 cutaneous B-cell lymphoid proliferations was analyzed for the presence of the (14; 18) translocation using the polymerase chain reaction. Junctional sequences of rearranged chromosomes 14 and 18 were amplified in vitro, and t (14; 18) specific sequences were detected in 1 of 14 primary cutaneous B-cell lymphomas, in 3 of 8 primary nodal B-cell lymphomas and in none of 3 B-cell pseudolymphomas. These results indicate that the t (14; 18) may occur in a small subset of primary cutaneous lymphoma. However, the difference in incidence of the t (14; 18) between primary nodal and primary cutaneous lymphomas suggests that different molecular mechanisms are involved in the pathogenesis of these lymphomas.
authors: Department of Dermatology, University of Munich, Germany.
authors: M
authors: M
authors: Volkenandt
authors: L
authors: L
authors: Cerroni
authors: E
authors: E
authors: Rieger
authors: H P
authors: HP
authors: Soyer
authors: O
authors: O
authors: Koch
authors: R
authors: R
authors: Wienecke
authors: J
authors: J
authors: Atzpodien
authors: J R
authors: JR
authors: Bertino
authors: H
authors: H
authors: Kerl
mesh_terms: D001483:Base Sequence; D002883:Chromosomes, Human, Pair 14; D002887:Chromosomes, Human, Pair 18; D004273:DNA, Neoplasm / Q000235:genetics; D005784:Gene Amplification; D006801:Humans; D007150:Immunohistochemistry; D016393:Lymphoma, B-Cell / Q000235:genetics*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012878:Skin Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: D004273:DNA, Neoplasm