Temperature-dependent substrate inhibition of the cysteine proteinase (GP57/51) from Trypanosoma cruzi.
Lima
A P
AP
Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brazil.
Scharfstein
J
J
Storer
A C
AC
Ménard
R
R
D000818:Animals; D000953:Antigens, Protozoan / Q000378:metabolism*; D003374:Coumarins / Q000494:pharmacology; D003546:Cysteine Endopeptidases / Q000187:drug effects / Q000378:metabolism*; D015853:Cysteine Proteinase Inhibitors / Q000494:pharmacology*; D004151:Dipeptides / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006023:Glycoproteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D014349:Trypanosoma cruzi / Q000201:enzymology*
D000953:Antigens, Protozoan; D003374:Coumarins; D015853:Cysteine Proteinase Inhibitors; D004151:Dipeptides; D006023:Glycoproteins; C021159:benzyloxycarbonyl-phenylalanylarginine-4-methylcoumaryl-7-amide; C069012:benzyloxycarbonylarginyl-arginine 4-methylcoumarin-7-ylamide; D003546:Cysteine Endopeptidases; C073182:GP57-51 antigen, Trypanosoma cruzi