The dominance of a multiresistant strain of Neisseria gonorrhoeae among prostitutes and STD patients in The Gambia.
OBJECTIVE
To study the epidemiology of antibiotic resistant strains of Neisseria gonorrhoeae from sexually transmitted disease clinics in The Gambia.


METHODS
One hundred and sixty five strains of N gonorrhoeae were tested for their antibiotic susceptibility, auxotype, serotype, and plasmid content.


RESULTS
Of the total population 84 (51%) were non-penicillinase producing (nonPPNG) and 81 (49%) penicillinase-producing N gonorrhoeae (PPNG). There were 16 serovars, five auxotypes and 33 auxotype/serovar (A/S) classes in the total population and the nonPPNG. Among PPNG only five serovars, two auxotypes and nine A/S classes were found. One A/S class predominated, NR/IB-7 (86 isolates), of which 66 (77%) were PPNG and the remainder were chromosomally-mediated resistant N gonorrhoeae (CMRNG). These strains also showed reduced susceptibility to ciprofloxacin, ceftriaxone and tetracycline and were evenly distributed among patient groups.


CONCLUSIONS
We have identified a relatively homogeneous gonococcal population with a core group of isolates exhibiting high levels of antibiotic resistance.
Ison
C A
CA
Department of Medical Microbiology, St Mary's Hospital Medical School, Paddington, London, UK.
Pepin
J
J
Roope
N S
NS
Demba
E
E
Secka
O
O
Easmon
C S
CS
D004352:Drug Resistance, Microbial; D005260:Female; D005714:Gambia / Q000453:epidemiology; D006069:Gonorrhea / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D006801:Humans; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000302:isolation & purification; D012703:Serotyping; D011477:Sex Work; D015231:Sexually Transmitted Diseases, Bacterial / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*