title: Potent inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. A proposal on the nature of the binding interaction between the Asp-carboxylate of RGDX mimetics and the platelet GP IIb-IIIa receptor.
authors: Department of Medicinal Chemistry, Searle Research & Development, Skokie, Illinois 60077.
authors: J A
authors: JA
authors: Zablocki
authors: M
authors: M
authors: Miyano
authors: S N
authors: SN
authors: Rao
authors: S
authors: S
authors: Panzer-Knodle
authors: N
authors: N
authors: Nicholson
authors: L
authors: L
authors: Feigen
mesh_terms: D000595:Amino Acid Sequence; D005340:Fibrinogen / Q000378:metabolism / Q000494:pharmacology*; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D019038:Platelet Glycoprotein GPIb-IX Complex; D010980:Platelet Membrane Glycoproteins; D011971:Receptors, Immunologic / Q000187:drug effects / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D009842:Oligopeptides; D010975:Platelet Aggregation Inhibitors; D019038:Platelet Glycoprotein GPIb-IX Complex; D010980:Platelet Membrane Glycoproteins; D011971:Receptors, Immunologic; C032193:glycoprotein receptor GPIb-IX; D005340:Fibrinogen