Qualitative and quantitative experimental models to aid in risk assessment for immunotoxicology.
We have previously reported on the design and content of a screening battery using a "tier" approach for detecting potential immunosuppressive compounds in mice [1]. This battery was composed of various immune function, immunopathology and host resistance tests, the results of which could help establish the potential of chemical and biological agents to cause immunosuppression. The data from these studies, which now encompass over 50 compounds, have been analyzed in an attempt to improve future testing strategies and provide information to aid in the risk assessment process. Specifically, the following two issues will be addressed; what are the likelihood(s) for each of the individual tests and testing configurations to accurately identify immunotoxic compounds? and what are the quantitative and qualitative relationships between the immune tests and host resistance assays?
Luster
M I
MI
Systems Toxicity Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Pait
D G
DG
Portier
C
C
Rosenthal
G J
GJ
Germolec
D R
DR
Comment
C E
CE
Munson
A E
AE
White
K
K
Pollock
P
P
D000818:Animals; D007108:Immune Tolerance; D007159:Immunologic Tests; D007166:Immunosuppressive Agents / Q000633:toxicity*; D051379:Mice; D008810:Mice, Inbred C57BL; D012307:Risk Factors; D014116:Toxicology / Q000379:methods*
D007166:Immunosuppressive Agents