[Adverse effects of Ferrum Lec (clinico-experimental study)].
Summation of negative effects of hypoxia and lysosome-tropic properties of Ferrum Lec was observed in patients with severe stage of iron-deficiency anemia (IDA), and in rabbits with experimental IDA, during treatment by intravenous injections of Ferrum Lec. These effects were expressed in exageration of the destabilizing action of hypoxia on lysosome membranes, and attended by a significant rise in the lysosomal enzyme levels of blood plasma, by the development of dystrophic processes in hepatocytes, and by a decrease in the number of sinusoidal cells. All these facts should be considered in clinical practice.
Pospelova
T I
TI
Ageeva
T A
TA
Loseva
M I
MI
Shkurupiĭ
V A
VA
Grek
O R
OR
Pupyshev
A B
AB
D000747:Anemia, Hypochromic / Q000188:drug therapy*; D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D006432:Hemochromatosis / Q000139:chemically induced* / Q000517:prevention & control; D006801:Humans; D000860:Hypoxia / Q000139:chemically induced* / Q000517:prevention & control; D007275:Injections, Intravenous; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D011134:Polysaccharides / Q000008:administration & dosage / Q000009:adverse effects*; D011817:Rabbits
D009942:Organometallic Compounds; D011134:Polysaccharides; C009766:ferrum lek
Ob otritsatel'nykh éffektakh preparata Ferrum Lek (kliniko- éksperimental'noe issledovanie).