Prediction of advanced puberty by height velocity in children with acute lymphoblastic leukemia.
Pubertal development was retrospectively evaluated in 58 children with cancer, mostly acute lymphoblastic leukemia (ALL), who are in complete remission and off chemotherapy. Six girls [5 patients with ALL, and 1 with malignant lymphoma (NHL)] showed advanced puberty (25.0%, 6 of 24 female patients with ALL and NHL) through the evaluation of their growth velocity. No evidence for advanced puberty was seen in the males. All 6 girls had received cranial irradiation for central nervous system prophylaxis and systemic chemotherapy including glucocorticoid. The mean age at onset of the pubertal growth spurt in these 6 girls was significantly lower than for girls with a solid tumor [6.90 +/- 0.10 and 9.00 +/- 0.77 (mean +/- SD) years, respectively (p < 0.01)]. By simply evaluating the height velocity, we could predict advanced puberty which was ultimately associated with short stature.
Kawasaki
H
H
Department of Pediatrics, Mie University School of Medicine, Japan.
Azuma
E
E
Washio
S
S
Taneda
H
H
Kubo
M
M
Ido
M
M
Sakurai
M
M
D000293:Adolescent; D001827:Body Height; D001932:Brain Neoplasms / Q000517:prevention & control; D001940:Breast / Q000033:anatomy & histology; D002648:Child; D004958:Estradiol / Q000097:blood; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008223:Lymphoma / Q000532:radiotherapy; D008297:Male; D008572:Menarche; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000503:physiopathology* / Q000532:radiotherapy; D011629:Puberty, Precocious / Q000175:diagnosis* / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects*; D012189:Retrospective Studies
D004958:Estradiol; D007986:Luteinizing Hormone; D013006:Growth Hormone