Thyroliberin (TRH) increases thymus cell proliferation in rats.
The effects of thyroliberin (TRH), a TRH-like tripeptide colon mitosis inhibitor (CMI), a somatostatin analog SMS 201-995 and metoclopramide (dopamine receptor antagonist enhancing prolactin secretion) on rat thymus cell proliferation were investigated. The incorporation of bromodeoxyuridine (BrDU) into thymic cell nuclei was used as an index of the proliferation. It was found that TRH, but not other compounds investigated herein, increased the thymus cell proliferation 12 hours after the injection.
Pawlikowski
M
M
Department of Experimental Endocrinology and Hormone Diagnostics, Medical Academy of Lódź, Poland.
Zerek-Mełeń
G
G
Winczyk
K
K
D000595:Amino Acid Sequence; D000818:Animals; D001973:Bromodeoxyuridine / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D008969:Molecular Sequence Data; D015282:Octreotide / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D051381:Rats; D017208:Rats, Wistar; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D009842:Oligopeptides; D013973:Thyrotropin-Releasing Hormone; C023866:pyroglutamyl-histidyl-glycine; D001973:Bromodeoxyuridine; D008787:Metoclopramide; D015282:Octreotide; D011761:Pyrrolidonecarboxylic Acid