title: [N-phosphorylated amino acids as potential cytostatics].
abstract: Phosphoramidic dichlorides 3 are synthesized by nucleophilic attack of methyl 2-(1-ethylenimino)-alkanoates 1 on POCl3 or by the reaction of amino acid methyl ester hydrochlorides 2 with POCl3. Subsequent treatment of 3 with ethylenimine affords the TEPA-analogs 4, and with 3-(1-ethylenimino)-1-propanol (6) the IFOSFAMID analogous 1,3,2-oxaza-phosphorines 5, the cytostatic activity of which was tested in the P388-leukemia of the CD2F1-mouse.
authors: Institut für Pharmazeutische Chemie, Westfälischen Wilhelms-Universität, Münster.
authors: J F
authors: JF
authors: Schwieger
authors: B
authors: B
authors: Unterhalt
mesh_terms: D000596:Amino Acids / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D008815:Mice, Inbred Strains; D010766:Phosphorylation
chemical_list: D000596:Amino Acids; D000970:Antineoplastic Agents
vernacular_title: N-Phosphorylierte Aminosäuren als potentielle Zytostatika.