title: [A histopathological study of the hepatic changes induced by parenteral nutrition in the rat].
abstract: Total parenteral nutrition is associated with hepatic metabolic and morphologic changes. Histological alterations induced by administration of glucose plus amino acids (group A) or glucose plus amino acids and lipids (group B) have been investigated in the rat. Parenteral nutrition provided 187 kcal/kg/day in both groups of animals. Rats in group B received 30% of nonprotein calories as lipids (Intralipid). In group A the most frequent histopathological findings were inflammation, portal edema and microesteatosis. Those alterations did not disappear by lipid addition, being frequent the existence of congestive phenomenons and esteatosis together with occasional pigment deposits in Kupffer cells. Those data suggest that supplementation of solutions with LCT-base lipid emulsions does not compensate for the histopathological alterations induced by parenteral nutrition.
authors: Unidad de Investigación, Complejo Hospitalario de León, Spain.
authors: J
authors: J
authors: García Vielba
authors: T
authors: T
authors: Ribas Ariño
authors: F
authors: F
authors: García Díez
authors: M L
authors: ML
authors: de la Hoz Riesco
authors: J
authors: J
authors: González Gallego
authors: J M
authors: JM
authors: Culebras
mesh_terms: D000818:Animals; D005217:Fat Emulsions, Intravenous / Q000009:adverse effects; D005234:Fatty Liver / Q000209:etiology / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008297:Male; D010288:Parenteral Nutrition / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005217:Fat Emulsions, Intravenous
vernacular_title: Estudio histopatológico de las alteraciones hepáticas inducidas por la nutrición parenteral en la rata.