On the protective mechanism of the sickle cell trait (HbAS).
The sickle cell trait has been reported to offer some protection against anaemia in pregnancy. Some attribute this to the break up of the cells which release iron for the synthesis of haemoglobin. The hypothesis presented here is that the 'partial' protective mechanism of the sickle cell trait is due to increased erythropoietic activity.
Pepple
D J
DJ
Department of Human Physiology, College of Medical Sciences, University of Maiduguri, Nigeria.
D000740:Anemia / Q000097:blood / Q000150:complications / Q000517:prevention & control; D004920:Erythropoiesis; D005260:Female; D006801:Humans; D008954:Models, Biological; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000517:prevention & control; D012805:Sickle Cell Trait / Q000097:blood* / Q000150:complications