Blood sample analysis and monitoring of hemodynamic parameters and renal function in the conscious rat.
A method is described for chronic instrumentation of the rat with arterial and venous catheters. The technique minimizes the risk of catheter occlusion and damage, and reduces restraint of the animals during the evaluation. In the conscious animal, hemodynamic parameters and renal function can be monitored while substances are injected or blood samples withdrawn.
Hohenfellner
M
M
Department of Physiology, University of Munich, Germany.
Schmausser
U
U
Klein
H G
HG
Brechtelsbauer
H
H
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood; D001794:Blood Pressure; D001810:Blood Volume; D002302:Cardiac Output; D002406:Catheterization, Peripheral / Q000379:methods*; D005260:Female; D006339:Heart Rate; D006439:Hemodynamics; D007328:Insulin / Q000493:pharmacokinetics; D007668:Kidney / Q000502:physiology*; D008297:Male; D008991:Monitoring, Physiologic; D051381:Rats; D017207:Rats, Sprague-Dawley
D007328:Insulin; D009320:Atrial Natriuretic Factor