title: Colonisation with digoxin-reducing strains of Eubacterium lentum and Clostridium difficile infection in nursing home patients.
abstract: Stool specimens obtained from 77 residents of a nursing home were analysed to determine the relationship between colonisation with digoxin-reducing strains of Eubacterium lentum and infection with Clostridium difficile. Patients were categorised according to previous antibiotic treatment, prescription of enteral feedings, and pattern of bowel habits. Colonisation with digoxin-reducing E. lentum was less common in subjects infected with C. difficile, in those treated with antibiotics previously, and in those prescribed enteral feedings. Normal bowel habits were more common in those without C. difficile. The lowest incidence of diarrhoea was seen in patients without C. difficile who were colonised with digoxin-reducing species. This study establishes an inverse relationship between the presence of C. difficile and E. lentum that reduce digoxin which is related to previous treatment with antibiotics and prescription of enteral feedings. Bacterial markers may prove to be a useful tool for predicting clinical disturbances in bowel function.
authors.affiliation: Division of Geriatric Medicine, Johns Hopkins University School of Medicine, Johns Hopkins Geriatrics Center, Baltimore, Maryland 21224.
authors.forename: R G
authors.initials: RG
authors.lastname: Bennett
authors.forename: B A
authors.initials: BA
authors.lastname: Beamer
authors.forename: W B
authors.initials: WB
authors.lastname: Greenough
authors.forename: J
authors.initials: J
authors.lastname: Lindenbaum
authors.forename: J G
authors.initials: JG
authors.lastname: Bartlett
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016360:Clostridioides difficile / Q000254:growth & development*; D003967:Diarrhea; D004077:Digoxin / Q000378:metabolism*; D004750:Enteral Nutrition; D004761:Enterocolitis, Pseudomembranous / Q000382:microbiology*; D005051:Eubacterium / Q000254:growth & development / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009735:Nursing Homes
chemical_list: D004077:Digoxin