[DCC gene and leukemia].
The deleted in colorectal carcinomas (DCC) gene, located in human chromosome band 18q21, was identified as a potential tumor suppressor gene by Fearon et al. in 1990. The DCC gene encodes a protein which is highly similar to neural cell adhesion molecules and other related cell surface glycoproteins. In colorectal carcinoma, the expression of the DCC gene is reduced or absent in 88% of cases. We examined the expression of the DCC gene using reverse transcriptase-polymerase chain reaction (RT-PCR) analysis. Its expression was reduced or absent in some leukemias. Our findings suggest the possibility that this gene may play a role in leukemogenesis.
Miyake
K
K
Third Department of Internal Medicine, Nippon Medical School.
Inokuchi
K
K
D001483:Base Sequence; D015972:Gene Expression Regulation, Neoplastic; D016163:Genes, DCC; D016147:Genes, Tumor Suppressor; D006801:Humans; D007938:Leukemia / Q000209:etiology / Q000235:genetics*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction