title: Localization of type I interferon in murine trophoblast and decidua during decidual formation.
abstract: Mouse trophoblast and decidua were examined by means of immunohistochemistry to define the localization of type I interferon. The decidua were stained for type I interferon at the time of implantation. The strong reaction was first observed in the primary decidual zone on day 5 and subsequently in the secondary decidual zone on day 6. After day 10, the decidua basalis and decidua capsularis showed a strong reaction. At the one-cell stage, embryos were weakly labelled, but a positive reaction was recognized in compacted morulae. Blastocysts on days 3 and 4 were positive in trophoblast and inner cell mass and a strong reaction was observed in the primitive endoderm on day 4. The visceral endoderm on day 5 and the trophoblast on day 6 were positive. After day 10, the trophoblast giant cells, labyrinth, visceral yolk sac and fetal blood cells gave a positive reaction. This study is the first demonstration of type I interferon localization in situ in mouse trophoblast and decidua during decidual formation.
authors.affiliation: Department of Veterinary Anatomy, Faculty of Agriculture, University of Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: M
authors.initials: M
authors.lastname: Kurohmaru
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashi
mesh_terms: D000818:Animals; D003656:Decidua / Q000254:growth & development / Q000276:immunology*; D004971:Estrus / Q000276:immunology; D005260:Female; D007150:Immunohistochemistry; D007370:Interferon Type I / Q000032:analysis*; D051379:Mice; D008810:Mice, Inbred C57BL; D009028:Morula / Q000276:immunology; D011247:Pregnancy; D014327:Trophoblasts / Q000276:immunology*; D014599:Uterus / Q000276:immunology
chemical_list: D007370:Interferon Type I