Association of a polymorphism in the Apo AI gene promoter with hyperalphalipoproteinemia.
The distribution of a polymorphism due to an Adenine to Guanine transition in the ApoAI gene has been studied in 136 women and 108 men, through amplification of the promoter region of the gene and allele-specific oligonucleotide hybridization. The allelic frequencies for the A allele were 0.10, 0.14 and 0.27 in women and 0.08, 0.17 and 0.14 in men for the lowest decile, intermediate group and the highest decile of HDL-cholesterol levels, respectively. Statistical analysis showed that the A allele was associated with high HDL-cholesterol levels in women, but not in men.
Pagani
F
F
Fondazione Rivetti, Milan, Italy.
Giudici
G A
GA
Baralle
F E
FE
Vergani
C
C
D000483:Alleles; D016632:Apolipoprotein A-I / Q000235:genetics* / Q000502:physiology; D008076:Cholesterol, HDL / Q000097:blood* / Q000235:genetics; D004247:DNA / Q000235:genetics; D005260:Female; D006801:Humans; D006951:Hyperlipoproteinemias / Q000097:blood / Q000235:genetics*; D008075:Lipoproteins, HDL / Q000097:blood* / Q000235:genetics; D008297:Male; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization / Q000502:physiology*; D015345:Oligonucleotide Probes; D011110:Polymorphism, Genetic / Q000235:genetics* / Q000502:physiology; D011401:Promoter Regions, Genetic / Q000235:genetics* / Q000502:physiology; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D012737:Sex Factors
D016632:Apolipoprotein A-I; D008076:Cholesterol, HDL; D008075:Lipoproteins, HDL; D015345:Oligonucleotide Probes; D004247:DNA