title: Insulin-like peptide(s) in the central nervous system of the snail Helisoma duryi.
abstract: The central nervous system of the snail Helisoma duryi contains porcine insulin-immunoreactive cells. Most of these cells are known as neurosecretory mediodorsal cells (MDC), and are involved in regulation of growth. There are about 25-40 large and small MDC in each cerebral ganglion near the commissure. Besides the MDC, 6-8 insulin-immunoreactive cells are also seen in the left parietal ganglion and the visceral ganglion. Insulin-immunoreactive material can be traced from the MDC perikarya into their axons in the median lip nerve. The elementary granules of the MDC are 150-250 nm in diameter, and are insulin-immunoreactive. Insulin-like material is released by the CNS in vitro, and can be measured by radioimmunoassay using an antiserum against human insulin. High potassium and 4-aminopyridine increase such release in vitro. It is likely that insulin-like peptide is a growth hormone in H. duryi.
authors.affiliation: Department of Biology, York University, Toronto, Ont., Canada.
authors.forename: H R
authors.initials: HR
authors.lastname: Khan
authors.forename: B
authors.initials: B
authors.lastname: Griffond
authors.forename: A S
authors.initials: AS
authors.lastname: Saleuddin
mesh_terms: D015761:4-Aminopyridine / Q000494:pharmacology; D000818:Animals; D001923:Brain Chemistry / Q000502:physiology; D002478:Cells, Cultured; D007124:Immunoenzyme Techniques; D007328:Insulin / Q000032:analysis*; D009479:Neuropeptides / Q000032:analysis*; D011188:Potassium / Q000494:pharmacology; D011863:Radioimmunoassay; D012908:Snails / Q000737:chemistry*
chemical_list: D007328:Insulin; D009479:Neuropeptides; D015761:4-Aminopyridine; D011188:Potassium