title: Synthesis and pharmacology of 3-aryl-5,6-dihydro-6-oxo-1(4H)-pyridazineacetic acid derivatives.
abstract: The title compounds were prepared by alkylation of 6-aryl-4,5-dihydro-3(2H)-pyridazinones with esters of alpha-bromoacetic acid. Hydrolysis of these esters afforded the corresponding carboxylic acids which were coupled with various amines yielding 6-oxo-1(4H)-pyridazineacetamides. A number of these derivatives showed weak anticonvulsant and weak analgesic activities, while nearly all displayed a sedative profile.
authors.affiliation: Marion Merrell Dow Research Institute, Cincinnati, Ohio.
authors.forename: J M
authors.initials: JM
authors.lastname: Kane
authors.forename: E W
authors.initials: EW
authors.lastname: Huber
authors.forename: F P
authors.initials: FP
authors.lastname: Miller
authors.forename: J H
authors.initials: JH
authors.lastname: Kehne
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011619:Psychotropic Drugs / Q000138:chemical synthesis* / Q000494:pharmacology; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000700:Analgesics; D000927:Anticonvulsants; D011619:Psychotropic Drugs; D011724:Pyridazines