title: [Eremomycin in the treatment of antibiotic-associated colitis in golden hamsters].
abstract: The efficacy of eremomycin, a new glycopeptide antibiotic, was studied on a model of antibiotic-associated colitis in golden hamsters. The colitis was induced by intraperitoneal or intragastric administration of lincomycin. In a dose of 100 mg/kg administered orally once a day for 5 days eremomycin protected the animals from the lincomycin-induced colitis: some animals survived, the others died in later periods. When the animals were infected with a pathogenetic strain of Clostridium difficile followed by exposure to lincomycin the use of eremomycin produced the similar effect.
authors.forename: A A
authors.initials: AA
authors.lastname: Rukhlina
authors.forename: L A
authors.initials: LA
authors.lastname: Malkova
authors.forename: L A
authors.initials: LA
authors.lastname: Shevniuk
authors.forename: T V
authors.initials: TV
authors.lastname: Fomina
authors.forename: V M
authors.initials: VM
authors.lastname: Bukhman
authors.forename: V M
authors.initials: VM
authors.lastname: Koroleva
authors.forename: I N
authors.initials: IN
authors.lastname: Bakulin
authors.forename: T I
authors.initials: TI
authors.lastname: Sergeeva
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016360:Clostridioides difficile / Q000187:drug effects / Q000472:pathogenicity*; D006224:Cricetinae; D004195:Disease Models, Animal; D004761:Enterocolitis, Pseudomembranous / Q000139:chemically induced / Q000188:drug therapy* / Q000382:microbiology; D006020:Glycopeptides / Q000627:therapeutic use; D007274:Injections, Intraperitoneal; D008034:Lincomycin / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008647:Mesocricetus; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D006020:Glycopeptides; C053759:eremomycin; D008034:Lincomycin
vernacular_title: Lechenie éremomitsinom antibiotikoassotsiirovannogo kolita zolotistykh khomiachkov.