Dosing problems in the use of topical ophthalmic drops.
The effect of two drops of the same drug, one instilled immediately after the other, was compared to the effect of a single drop in 100 healthy volunteers. The drugs investigated were tropicamide, 0.125%, and phenylephrine, 2.5%. The mydriatic effect of two drops was 30%-35% stronger than the effect achieved by a single drop.
Loewenstein
A
A
Department of Ophthalmology, Ichilov Hospital, Tel Aviv, Israel.
Geyer
O
O
Blanc
A
A
Lazar
M
M
D000328:Adult; D006801:Humans; D009883:Ophthalmic Solutions; D010656:Phenylephrine / Q000008:administration & dosage* / Q000494:pharmacology; D011680:Pupil / Q000187:drug effects*; D014331:Tropicamide / Q000008:administration & dosage* / Q000494:pharmacology
D009883:Ophthalmic Solutions; D010656:Phenylephrine; D014331:Tropicamide