title: Induction of tolerance to an IgG autoantibody.
abstract: Nonautoimmune mice transgenic for the heavy chain of an IgG2b anti-double-stranded-DNA antibody express the transgene in lymphoid organs and display partial allelic exclusion of this gamma 2b transgene. The spleens of these mice are characterized by marked B-cell depletion. Although there are B cells in these mice that express the transgene and recognize double-stranded DNA, they are anergic in vivo. Recovery from the state of anergy occurs in vitro after lipopolysaccharide stimulation. Thus this transgenic model demonstrates the induction of self tolerance to an IgG autoantibody.
authors.affiliation: Department of Microbiology, Albert Einstein College of Medicine, Bronx, NY 10461.
authors.forename: D
authors.initials: D
authors.lastname: Offen
authors.forename: L
authors.initials: L
authors.lastname: Spatz
authors.forename: H
authors.initials: H
authors.lastname: Escowitz
authors.forename: S
authors.initials: S
authors.lastname: Factor
authors.forename: B
authors.initials: B
authors.lastname: Diamond
mesh_terms: D000818:Animals; D000974:Antibodies, Antinuclear / Q000235:genetics* / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D015870:Gene Expression; D005796:Genes; D007108:Immune Tolerance; D007074:Immunoglobulin G / Q000235:genetics* / Q000276:immunology; D007668:Kidney / Q000473:pathology; D008070:Lipopolysaccharides / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic; D012333:RNA, Messenger / Q000235:genetics; D013154:Spleen / Q000473:pathology
chemical_list: D000974:Antibodies, Antinuclear; D007074:Immunoglobulin G; D008070:Lipopolysaccharides; D012333:RNA, Messenger