Duodenal acidification and intra-arterial injection of CCK8 increase gallbladder motility in the rainbow trout, Oncorhynchus mykiss.
A sensitive method for in vivo measurement of intra-gallbladder pressure in free swimming rainbow trout (Oncorhynchus mykiss) is described. The method gives information on changes in gallbladder pressure after either instillation of liquids into the duodenum or infusion/injection of agents into the circulatory system. Blood samples can also be taken. Duodenal acidification is a potent initiating factor for gallbladder motility in the rainbow trout. Intra-arterially injected sulfated octapeptide of cholecystokinin is also a potent excitatory agent for activating the gallbladder. Acidification of the upper intestine causes release of cholecystokinin, which affects gallbladder motility in trout as in mammals.
Aldman
G
G
Department of Zoophysiology, University of Göteborg, Sweden.
Grove
D
D
Holmgren
S
S
D000818:Animals; D001652:Bile Ducts / Q000502:physiology / Q000601:surgery; D004386:Duodenum / Q000502:physiology*; D005704:Gallbladder / Q000187:drug effects / Q000502:physiology*; D006863:Hydrogen-Ion Concentration; D007269:Injections, Intra-Arterial; D008026:Ligation; D011312:Pressure; D012844:Sincalide / Q000008:administration & dosage / Q000494:pharmacology*; D014337:Trout / Q000502:physiology*
D012844:Sincalide