title: Treatment for necrotizing enterocolitis perforation in the extremely premature infant (weighing less than 1,000 g).
abstract: The frequency of necrotizing enterocolitis (NEC) in the extremely premature infant (less than 1,000 g) is still high and it is very difficult for infants weighing less than 1,000 g with NEC perforation to survive. In our institutes, the management protocol for NEC perforation in infants weighing less than 1,000 g includes peritoneal drainage under local anesthesia, administration of coagulating factor XIII, and the usual treatment for septic shock. During the past 3 years, four infants weighing less than 1,000 g with NEC perforation have survived using this protocol without laparotomy. This management protocol is the treatment of choice in infants in very poor condition or infants weighing less than 1,000 g with NEC perforation.
authors.affiliation: Department of Pediatric Surgery, Kagoshima University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Takamatsu
authors.forename: H
authors.initials: H
authors.lastname: Akiyama
authors.forename: S
authors.initials: S
authors.lastname: Ibara
authors.forename: S
authors.initials: S
authors.lastname: Seki
authors.forename: K
authors.initials: K
authors.lastname: Kuraya
authors.forename: T
authors.initials: T
authors.lastname: Ikenoue
mesh_terms: D004200:Diseases in Twins; D004322:Drainage; D004761:Enterocolitis, Pseudomembranous / Q000175:diagnosis / Q000628:therapy*; D005176:Factor XIII / Q000627:therapeutic use; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000628:therapy*; D007416:Intestinal Perforation / Q000175:diagnosis / Q000628:therapy*; D008297:Male; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy
chemical_list: D005176:Factor XIII