Induction and termination of afterdepolarizations and triggered arrhythmias by drugs in cat heart in vivo.
In order to investigate some anti-triggered arrhythmic drugs, the afterdepolarizations and triggered arrhythmias were induced by cesium chloride and the monophasic action potentials of the left ventricular epicardium in vivo were recorded by using a contact electrode in 58 cats. These results suggested that a) early- and afterdepolarizations, oscillatory afterpotentials and some different kinds of triggered arrhythmias were induced by cesium chloride, b) sodium valproate (150 mg/kg) could prevent CsCl-induced triggered activities, c) lidocaine (5 mg/kg), ethmozine (5 mg/kg) and sodium valproate (150 mg/kg) could terminate CsCl-induced ventricular tachycardias. The present studies provide a basically experimental evidence for treating triggered arrhythmias in clinic.
Xie
J T
JT
Department of Biology, Nankai University, Tianjin, PR of China.
Li
C L
CL
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D002415:Cats; D002586:Cesium / Q000494:pharmacology; D002712:Chlorides; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006321:Heart / Q000187:drug effects*; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D016293:Moricizine / Q000494:pharmacology; D009467:Neuromuscular Depolarizing Agents / Q000494:pharmacology*; D010640:Phenothiazines / Q000494:pharmacology; D013617:Tachycardia, Supraventricular / Q000503:physiopathology; D014635:Valproic Acid / Q000494:pharmacology
D000889:Anti-Arrhythmia Agents; D002712:Chlorides; D009467:Neuromuscular Depolarizing Agents; D010640:Phenothiazines; D002586:Cesium; D016293:Moricizine; D014635:Valproic Acid; D008012:Lidocaine; C046818:ethacizine; C028019:cesium chloride