title: Glibenclamide depresses the slowly inactivating outward current (ID) in hippocampal neurons.
abstract: Sulphonylurea drugs, such as glibenclamide and tolbutamide, are widely used as selective blockers of adenosine triphosphate-sensitive K channels. In experiments on hippocampal slices (from Wistar rats) glibenclamide (and possibly gliquidone and tolbutamide) significantly reduced the highly voltage-dependent, 4-aminopyridine-sensitive D-type outward current of CA3 neurons. Judging by these observations, the sulphonylureas may not be as selective as generally believed.
authors.affiliation: Anaesthesia Research Department, McGill University, Montréal, Québec, Canada.
authors.forename: V
authors.initials: V
authors.lastname: Crépel
authors.forename: K
authors.initials: K
authors.lastname: Krnjević
authors.forename: Y
authors.initials: Y
authors.lastname: Ben-Ari
mesh_terms: D000818:Animals; D005905:Glyburide / Q000494:pharmacology*; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism*; D066298:In Vitro Techniques; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D015221:Potassium Channels / Q000187:drug effects*; D011712:Pyramidal Tracts / Q000166:cytology / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013569:Synapses / Q000187:drug effects / Q000378:metabolism
chemical_list: D015221:Potassium Channels; D005905:Glyburide