Feasibility of adenovirus-mediated gene transfer in vivo.
We have evaluated the use of Adenovirus as a new vector for gene transfer in vivo. The capacity of this virus to express a foreign gene even in the absence of viral and cellular replication makes it attractive to deliver a gene to quiescent cells. We show here that organs like lung, liver and muscles are relevant to this strategy.
Stratford-Perricaudet
L D
LD
UA 1301 of CNRS, Institut Gustave Roussy, Villejuif, France.
Briand
P
P
Perricaudet
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M
D000256:Adenoviridae / Q000235:genetics*; D000818:Animals; D005240:Feasibility Studies; D015967:Gene Expression Regulation, Viral; D005822:Genetic Vectors; D006801:Humans; D051379:Mice; D008817:Mice, Mutant Strains; D009954:Ornithine Carbamoyltransferase / Q000235:genetics; D011993:Recombinant Fusion Proteins / Q000235:genetics; D014162:Transfection
D011993:Recombinant Fusion Proteins; D009954:Ornithine Carbamoyltransferase