Metabolism of glucurolactone to glucarate in Parkinson's disease.
The metabolism of oral glucurolactone to serum D-glucarate by the hepatic cytochrome P450 enzyme system was no different in 20 untreated Parkinson's disease (PD) patients as compared with 20 age- and sex-matched controls. There was no evidence for a deficit in hepatic enzymes in PD.
Koller
W C
WC
Department of Neurology, University of Kansas Medical Center, Kansas City 66160-7314.
Rope
S D
SD
Huber
S J
SJ
Blumenthal
D C
DC
Blumenthal
H J
HJ
D000284:Administration, Oral; D000368:Aged; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005260:Female; D005937:Glucaric Acid / Q000097:blood*; D005965:Glucuronates / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000201:enzymology; D008297:Male; D010300:Parkinson Disease / Q000378:metabolism*
D005965:Glucuronates; C004940:glucuronolactone; D003577:Cytochrome P-450 Enzyme System; D005937:Glucaric Acid