title: Enhancement of antibody response of turkeys to trivalent avian influenza vaccine by positively charged liposomal avridine adjuvant.
abstract: Trivalent avian influenza (AIV) antigens (H4N8, H5N2 and H7N3), mixed with positively charged, negatively charged and neutral avridine-containing liposomes, and oil-emulsion were subcutaneously administered to 6-week-old turkeys. Charged liposomal avridine adjuvant, either positive or negative, produced a better antibody response than uncharged liposomal avridine or oil-emulsion adjuvants when used in a trivalent avian influenza vaccine. The antibody response to the different antigens was generally greater to the positively charged adjuvanted vaccine compared with the negatively or neutral charged or oil-emulsion adjuvanted vaccines and these differences were significant (P less than 0.05) with the three antigens. The results suggest that the positively charged liposomal avridine plays a significant role as adjuvant to the AIV antigens.
authors.affiliation: Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St Paul 55108.
authors.forename: O O
authors.initials: OO
authors.lastname: Fatunmbi
authors.forename: J A
authors.initials: JA
authors.lastname: Newman
authors.forename: V
authors.initials: V
authors.lastname: Sivanandan
authors.forename: D A
authors.initials: DA
authors.lastname: Halvorson
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000956:Antigens, Viral / Q000008:administration & dosage; D003959:Diamines / Q000008:administration & dosage; D004563:Electrochemistry; D005260:Female; D009980:Influenza A virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage*; D005585:Influenza in Birds / Q000517:prevention & control*; D008081:Liposomes; D013499:Surface Properties; D014422:Turkeys
chemical_list: D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D000956:Antigens, Viral; D003959:Diamines; D007252:Influenza Vaccines; D008081:Liposomes; C006270:avridine