Deletion 12p in de novo acute myeloid leukemia. An association with early progenitor cell.
Deletion of the short arm of chromosome 12 as the sole karyotypic abnormality was found in three cases of acute myeloblastic leukemia (AML). In contrast to what has previously been reported in the literature, none of our cases had an antecedent history of myelodysplasia or toxic exposure, and basophilia was absent. Two cases were terminal deoxynucleotidyl transferase (TdT) positive, suggesting involvement of an early progenitor cell.
Chan
L C
LC
Department of Pathology, Queen Mary Hospital, University of Hong Kong.
Kwong
Y L
YL
Liu
H W
HW
Lee
C P
CP
Lie
K W
KW
Chan
A Y
AY
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002872:Chromosome Deletion; D002881:Chromosomes, Human, Pair 12; D004253:DNA Nucleotidylexotransferase; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male
D004253:DNA Nucleotidylexotransferase