title: Isolation of a beta-lactamase-producing, aminoglycoside-resistant strain of Enterococcus faecium.
abstract: Beta-Lactamase-producing, aminoglycoside-resistant strains of Enterococcus faecalis have been isolated from different geographic areas and are endemic at our institution. We report the isolation of a beta-lactamase-producing, aminoglycoside-resistant strain of E. faecium. The beta-lactamase was plasmid mediated and transferable with high frequency into a plasmid-free E. faecalis recipient strain. MICs suggested that the E. faecium strain also contained intrinsic (chromosomal) resistance to penicillins.
authors.affiliation: Department of Pathology, McGuire Veterans Affairs Medical Center, Richmond, Virginia 23249.
authors.forename: P E
authors.initials: PE
authors.lastname: Coudron
authors.forename: S M
authors.initials: SM
authors.lastname: Markowitz
authors.forename: E S
authors.initials: ES
authors.lastname: Wong
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D016984:Enterococcus faecium / Q000187:drug effects / Q000201:enzymology / Q000302:isolation & purification*; D006801:Humans; D008826:Microbial Sensitivity Tests; D001618:beta-Lactamases / Q000096:biosynthesis
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D001618:beta-Lactamases