Evaluation of bone metabolic markers as indicators of osteopenia in climacteric women.
Lumbar bone mass (LBM) determination by quantitative computerized tomography in pre-, peri- and postmenopausal women was utilized to identify subjects at risk to develop osteoporosis. The results were related to determinations of bone metabolic markers (serum osteocalcin and urinary calcium excretion). Osteocalcin was the only metabolic marker which underwent significative changes. However, we found very poor correlations between LBM and metabolic markers and it is concluded that bone mass determination remains the method of choice to select women for preventive therapy.
Pansini
F
F
Department of Obstetrics and Gynecology, University of Ferrara, Italy.
Bonaccorsi
G
G
Calisesi
M
M
Farina
A
A
Levato
F
F
Mazzotta
D
D
Bagni
B
B
Mollica
G
G
D000328:Adult; D015415:Biomarkers; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D002118:Calcium / Q000652:urine*; D002136:Calcium, Dietary / Q000032:analysis; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging*; D008593:Menopause; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood*; D015663:Osteoporosis, Postmenopausal / Q000453:epidemiology* / Q000209:etiology; D011237:Predictive Value of Tests; D012307:Risk Factors; D014057:Tomography, X-Ray Computed / Q000592:standards*
D015415:Biomarkers; D002136:Calcium, Dietary; D015675:Osteocalcin; D003404:Creatinine; D002118:Calcium