title: Continuous thermodilution cardiac output measurement in sheep.
abstract: A technique has been developed to continuously measure cardiac output by means of the principles of thermodilution. Pulmonary artery catheters were modified by placing a 10 cm filament near the usual injectate port. Small amounts of heat were infused according to a randomly repeating binary on-off sequence. The distal blood temperature was recorded and cross-correlated with the heat waveform to produce a dilution curve and calculate cardiac output. The technique was compared with bolus thermodilution in seven sheep. Cardiac output ranged from 1.5 to 13.2 L/min, and heart rate varied from 59 to 180 beats/min. The linear regression between the data obtained by the two methods is represented by the equation y = 1.00x + 0.13; the correlation coefficient, R, is 0.97, and the p value is less than 0.0001.
authors.affiliation: InterFlo Medical, Inc., Plano, Tex. 75074.
authors.forename: M
authors.initials: M
authors.lastname: Yelderman
authors.forename: M D
authors.initials: MD
authors.lastname: Quinn
authors.forename: R C
authors.initials: RC
authors.lastname: McKown
authors.forename: R C
authors.initials: RC
authors.lastname: Eberhart
authors.forename: M L
authors.initials: ML
authors.lastname: Dollar
mesh_terms: D000818:Animals; D002302:Cardiac Output; D002407:Catheterization, Swan-Ganz; D006339:Heart Rate; D008991:Monitoring, Physiologic / Q000379:methods; D011651:Pulmonary Artery; D012044:Regression Analysis; D012756:Sheep; D012815:Signal Processing, Computer-Assisted; D013815:Thermodilution / Q000379:methods*