title: [Clinical evaluation of combined therapy of ceftazidime and tobramycin for intractable pulmonary infection mainly caused by Pseudomonas aeruginosa].
abstract: In an open, multicenter trial, we investigated the clinical efficacy of a combination therapy of ceftazidime (CAZ) and tobramycin (TOB) for intractable pulmonary infections mainly caused by Pseudomonas aeruginosa. Evaluated for the utility of the combination therapy were 33 cases with pneumonia (Group I: pneumonia caused by P. aeruginosa 15, Group II: pneumonia caused by other Gram-negative bacilli 4 and pneumonia which causative organism was not determined 14) and 23 cases with chronic respiratory tract infection caused by P. aeruginosa. The results obtained are summarized as follows. 1. In Group I pneumonia, included 11 severe cases and 4 moderate cases, with a mean age of 69.3 years. Significant underlying diseases were present in 14 out of the 15 (93.3%): they included 10 cases of pulmonary diseases and 4 cerebrovascular diseases. The overall efficacy rate in these cases was 60.0%: but the efficacy rate in moderate cases was 100% and that in severe cases was 45.5%. 2. In Group II pneumonia included 16 severe cases and 2 moderate cases with a mean age of 68.2 years. Significant underlying diseases were present in 15 out of 18 (83.3%, all of the underlying diseases were pulmonary diseases) and the overall efficacy rate was 72.2% with 100% efficacy rate among moderate cases and 68.8% among severe cases. 3. In the cases with chronic respiratory tract infections caused by P. aeruginosa, the efficacy rate was 82.6% and the eradication rate was 65.2%. We consider the combination therapy of CAZ and TOB is useful for intractable pulmonary infections caused by P. aeruginosa.
authors.affiliation: Department of Internal Medicine, Chiba Kaihin Municipal Hospital.
authors.forename: N
authors.initials: N
authors.lastname: Kikuchi
authors.forename: T
authors.initials: T
authors.lastname: Kawashima
authors.forename: H
authors.initials: H
authors.lastname: Igari
authors.forename: T
authors.initials: T
authors.lastname: Kuriyama
authors.forename: N
authors.initials: N
authors.lastname: Kohno
authors.forename: I
authors.initials: I
authors.lastname: Onozaki
authors.forename: N
authors.initials: N
authors.lastname: Muraki
authors.forename: R M
authors.initials: RM
authors.lastname: Miyazaki
authors.forename: H
authors.initials: H
authors.lastname: Kanno
authors.forename: N
authors.initials: N
authors.lastname: Ishiyama
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002442:Ceftazidime / Q000008:administration & dosage*; D004359:Drug Therapy, Combination / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000188:drug therapy*; D011552:Pseudomonas Infections / Q000188:drug therapy*; D012141:Respiratory Tract Infections / Q000188:drug therapy*; D014031:Tobramycin / Q000008:administration & dosage*
chemical_list: D002442:Ceftazidime; D014031:Tobramycin