title: Experimental Albizia versicolor poisoning in sheep and its successful treatment with pyridoxine hydrochloride.
abstract: Five sheep developed severe nervous signs after being drenched with Albizia versicolor pod-material. Four of these sheep were treated with pyridoxine hydrochloride (a vitamin B6) when the symptoms of toxicity became life-threatening. All the treated sheep recovered dramatically and completely after treatment while the untreated one died 2 h after receiving pod-material. A therapeutic dose of 20-25 mg pyridoxine hydrochloride/kg body mass given twice with an 8 h interval is the recommended treatment regimen. The route of administration will depend on the severity of symptoms. Chemical pathology and post-mortem findings are discussed.
authors.affiliation: Department of Infectious Diseases, Faculty of Veterinary Science, Onderstepoort.
authors.forename: B
authors.initials: B
authors.lastname: Gummow
authors.forename: S S
authors.initials: SS
authors.lastname: Bastianello
authors.forename: L
authors.initials: L
authors.lastname: Labuschagne
authors.forename: G L
authors.initials: GL
authors.lastname: Erasmus
mesh_terms: D000818:Animals; D005260:Female; D010865:Pilot Projects; D010939:Plant Poisoning / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D010947:Plants, Toxic; D011736:Pyridoxine / Q000627:therapeutic use*; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology
chemical_list: D011736:Pyridoxine