title: Etoposide microcrystals suspended in oil: a new dosage form to peritoneal carcinomatosis in mice.
abstract: Etoposide microcrystals suspended in oil (ETOP-OIL) were examined for their therapeutic effects on peritoneal carcinomatosis in mice. Two days after intraperitoneal inoculation with 10(5) P388 leukemia cells/mouse to CDF1 male mice, etoposide at 10-80 mg/kg was administered intraperitoneally in bolus in the form of ETOP-OIL or in the aqueous solution form. In every dose, the survival curve of the mice given ETOP-OIL was statistically significantly improved in spite of its small lethal toxicity, as compared with those given the identical dose of etoposide aqueous solution.
authors.affiliation: First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Hagiwara
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Sasabe
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: M
authors.initials: M
authors.lastname: Lee
authors.forename: C
authors.initials: C
authors.lastname: Sakakura
authors.forename: S
authors.initials: S
authors.lastname: Shoubayashi
authors.forename: S
authors.initials: S
authors.lastname: Tashima
authors.forename: S
authors.initials: S
authors.lastname: Muranishi
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000188:drug therapy*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D005047:Etoposide / Q000008:administration & dosage* / Q000009:adverse effects; D007274:Injections, Intraperitoneal; D007941:Leukemia P388 / Q000188:drug therapy / Q000473:pathology; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D009821:Oils; D010534:Peritoneal Neoplasms / Q000188:drug therapy*; D013535:Suspensions
chemical_list: D009821:Oils; D013535:Suspensions; D005047:Etoposide