title: The role of transthyretin in the transport of thyroid hormone to cerebrospinal fluid and brain.
abstract: Cerebrospinal fluid (CSF) transthyretin (TTR), the main CSF thyroxine (T4) carrier protein in the rat and the human is synthesized in the choroid plexus (CP). After injection of 125I-T4 in the rat, radioactive T4 accumulates first in the CP, then in the CSF and later in the brain. We have shown that competitive inhibition of T4-TTR binding sites in the CP and CSF by a flavonoid results in a decrease in the radioactivity present in the brain after i.v. injection of 125I-T4, suggesting that T4 transported to the CSF via the CP is a significant pathway for the supply of thyroid hormones to the brain.
authors.affiliation: Division of Endocrinology, University of Massachusetts Medical School, Worcester 01655.
authors.forename: J P
authors.initials: JP
authors.lastname: Chanoine
authors.forename: L E
authors.initials: LE
authors.lastname: Braverman
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D001921:Brain / Q000378:metabolism*; D002831:Choroid Plexus / Q000378:metabolism; D006801:Humans; D011228:Prealbumin / Q000502:physiology*; D013974:Thyroxine / Q000134:cerebrospinal fluid*
chemical_list: D011228:Prealbumin; D013974:Thyroxine