title: The effects of NaF, alpha-C12DMEAHF and alpha-C12DMEAHCl on caries development in dentine in situ.
abstract: Using histological techniques it was possible to demonstrate that during in situ caries development in bovine dentine, the demineralization process preceded the emergence and changes in the organic matrices. In addition, these data demonstrated as that 0.006% F- given either as the quaternary ammonium compound or NaF completely prevented demineralization by acting primarily on the dentine mineral. Inhibition by the quaternary ammonium compound alone was incomplete probably through repression of acid production by micro-organisms normally resident in the saliva.
authors.affiliation: Department of Prosthetic Dentistry, Academic Centre for Dentistry (ACTA), Amsterdam, The Netherlands.
authors.forename: E J
authors.initials: EJ
authors.lastname: van Croonenburg
authors.forename: J H
authors.initials: JH
authors.lastname: Wöltgens
authors.forename: D M
authors.initials: DM
authors.lastname: Lyaruu
authors.forename: H A
authors.initials: HA
authors.lastname: Veldman
mesh_terms: D000643:Ammonium Chloride; D000818:Animals; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002417:Cattle; D003094:Collagen; D003731:Dental Caries / Q000473:pathology / Q000517:prevention & control*; D003804:Dentin / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D008903:Minerals; D000644:Quaternary Ammonium Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000627:therapeutic use*; D013395:Sucrose / Q000494:pharmacology; D017001:Tooth Demineralization / Q000473:pathology / Q000517:prevention & control*
chemical_list: C079570:2-hydroxydodecyl 2-hydroxyethyl dimethyl ammonium chloride; C079569:2-hydroxyethyl 2-hydroxydodecyl dimethyl ammonium fluoride; D002327:Cariostatic Agents; D008903:Minerals; D000644:Quaternary Ammonium Compounds; D000643:Ammonium Chloride; D013395:Sucrose; D012969:Sodium Fluoride; D003094:Collagen