[Study of serum kinetics of vancomycin during the "antibiotic-lock" technique].
The serum kinetics of vancomycin was studied in two patients aged 3 and 15 years during antibiotic therapy for catheter related sepsis associated with Staphylococcus epidermidis. Vancomycin was administered, simultaneously, by parenteral conventional doses (30 mg/kg/day div q 8 h) and using the antibiotic-lock technique in the infected catheter at a high concentration (150 mg/ml) during one hour, 3 hours after each infusion. Pharmacokinetics data did not show any significant change in the serum kinetics of the antibiotic. The results suggest that delivering a high concentration of vancomycin in the infected catheter using the lock technique may be useful to sterilize infected catheter without toxic effect.
Elian
J C
JC
Service de Chimiothérapie Massive et Greffe de Moelle, Hôpital Nord, St-Priest-en-Jarez.
Frappaz
D
D
Ros
A
A
Gay
J P
JP
Guichard
D
D
Dorche
G
G
Aubert
G
G
Bouteille
M
M
Ollagnier
M
M
Freycon
F
F
D000293:Adolescent; D016470:Bacteremia / Q000188:drug therapy / Q000209:etiology; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002675:Child, Preschool; D006801:Humans; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000209:etiology; D013212:Staphylococcus epidermidis; D013530:Surgical Wound Infection / Q000188:drug therapy / Q000209:etiology; D014640:Vancomycin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use
D014640:Vancomycin
Etude de la cinétique sérique de la vancomycine au décours de la technique de "blocage in situ".