[The immunomodulating and hepatotropic effect of correcting hyperprolactinemia and hypophyseal gonadotropic dysfunction in liver cirrhosis patients].
Men suffering from liver cirrhosis were examined. They demonstrated a decrease in the blood content of gonadotropic hormones and testosterone and a rise of estradiol and prolactin. The changes indicated were more pronounced in decompensated liver cirrhosis and were associated with lipid peroxidation activation and a reduction of the count of T suppressor lymphocytes. As a result, the treatment of men suffering from decompensated liver cirrhosis and hyperprolactinemia by parlodel lowered blood prolactin and activity of lipid peroxidation. The use of chorionic gonadotropin for the treatment of men with decompensated liver cirrhosis and a low content of blood lutropin produces an immunomodulatory effect. Parlodel and chorionic gonadotropin favour a decrease of the cytolytic syndrome.
Okorokov
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D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D001971:Bromocriptine / Q000627:therapeutic use; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D002996:Clomiphene; D004359:Drug Therapy, Combination; D006065:Gonadotropins, Pituitary / Q000097:blood*; D006509:Hepatitis B / Q000150:complications; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D007111:Immunity, Cellular / Q000187:drug effects; D008099:Liver / Q000187:drug effects*; D008103:Liver Cirrhosis / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010900:Pituitary Diseases / Q000097:blood / Q000188:drug therapy* / Q000209:etiology
D000276:Adjuvants, Immunologic; D006063:Chorionic Gonadotropin; D006065:Gonadotropins, Pituitary; D002996:Clomiphene; D001971:Bromocriptine
Immunomoduliruiushchee i gepatotropnoe vliianie korrektsii giperprolaktinemii i gonadotropnoĭ disfunktsii gipofiza u bol'nykh tsirrozom pecheni.