Anticonvulsant effect of allopurinol on hippocampal-kindled seizures.
This study assessed the anticonvulsant effect of allopurinol (5 and 50 mg/kg, IP) on seizures kindled from the feline hippocampus. Allopurinol at a higher dose significantly reduced the behavioral seizures stage, but not afterdischarge duration, without producing any behavioral toxicity. The present results lend experimental support to the contention that allopurinol possesses anticonvulsant efficacy in the treatment of human epilepsy.
Wada
Y
Y
Department of Neuropsychiatry, Kanazawa University School of Medicine, Japan.
Hasegawa
H
H
Nakamura
M
M
Yamaguchi
N
N
D000493:Allopurinol / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D002415:Cats; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male
D000927:Anticonvulsants; D000493:Allopurinol