title: [Is down-staging of advanced bladder cancer by neoadjuvant chemotherapy possible?--MVEC protocol].
abstract: In 22 patients with advanced transitional cell carcinoma of the bladder, neoadjuvant chemotherapy according to the MVEC regimen was given. Subsequent radical cystectomy showed down-staging in 7 patients (32%). The preoperative clinical staging revealed regression of the bladder cancer in 77% of all cases. Down-grading was seen in only 2 patients. Because of the discrepancy between preoperative clinical staging and the histopathological staging after radical cystectomy, invasive tumour surgery is necessary even when clinical staging has not revealed a tumour after chemotherapy.
authors.affiliation: Urologische Klinik, Universität Witten/Herdecke, Verbandskrankenhaus Schwelm.
authors.forename: V
authors.initials: V
authors.lastname: Hoch
authors.forename: F
authors.initials: F
authors.lastname: Noll
authors.forename: F
authors.initials: F
authors.lastname: Schreiter
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000009:adverse effects / Q000627:therapeutic use; D003131:Combined Modality Therapy; D015653:Cystectomy; D015251:Epirubicin / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects / Q000627:therapeutic use; D008875:Middle Aged; D009367:Neoplasm Staging; D015996:Survival Rate; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D014747:Vinblastine / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D015251:Epirubicin; D014747:Vinblastine; D002945:Cisplatin; D008727:Methotrexate
vernacular_title: Gibt es ein Downstaging des fortgeschrittenen Blasenkarzinoms durch neoadjuvante Chemotherapie?--MVEC-Schema.