title: Metabolism of drugs: a reappraisal.
abstract: The paper deals with an up-to-date reappraisal of the most relevant aspects connected to the investigation of drug metabolism including the most appropriate methods used in preclinical and clinical field. Renal and biotransformation clearance is considered with several specific references. Reversible metabolism, active metabolites of drugs, various kinds of first pass effect, genetic polymorphism in drug metabolizing enzymes, the most appropriate pharmacokinetic analysis and regulatory aspects are the main aspects focused on.
authors.affiliation: Department of Drug Metabolism and Pharmacokinetics Sigma-Tau S.p.A., Pomezia, Roma.
authors.forename: A
authors.initials: A
authors.lastname: Marzo
mesh_terms: D000818:Animals; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism*
chemical_list: D004364:Pharmaceutical Preparations