Effects of postnatal aluminum exposure on choline acetyltransferase activity and learning abilities in the rat.
Young rats were treated by gastric intubation with aluminum lactate (0, 100, and 200 mg Al/kg/day) from postnatal days 5 to 14 to determine the treatment's influence on brain choline acetyltransferase activity and learning abilities. The results indicated that aluminum concentrations in the cerebral areas increased in parallel to plasma aluminum at the dose of 200 mg. In the same case, choline acetyltransferase activity was reduced. At postnatal days 50 and 100, the treated rats did not show alterations in their learning abilities in the 2 tests which are based on different motivations (avoidance of an aversive light or alimentary motivation) and different ways of achievement (pressing on a lever or running in a maze). A low reduction in the general activity, particularly in the radial maze test, was only observed in rats treated with 200 mg Al/kg/day.
Cherroret
G
G
Centre des Sciences de l'Environment, Neurotoxicologie, Université de Metz, France.
Bernuzzi
V
V
Desor
D
D
Hutin
M F
MF
Burnel
D
D
Lehr
P R
PR
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism* / Q000523:psychology; D002795:Choline O-Acetyltransferase / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects; D005260:Female; D007441:Intubation, Gastrointestinal; D007773:Lactates / Q000494:pharmacology*; D019344:Lactic Acid; D007858:Learning / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013037:Spatial Behavior
D007773:Lactates; D019344:Lactic Acid; D002795:Choline O-Acetyltransferase