Prognostic relevance of DNA ploidy in rhabdomyosarcomas and other sarcomas of childhood.
A study of DNA content by flow cytometry revealed a significant difference between rhabdomyosarcomas, which were mainly non-diploid, and other sarcomas of children which were mainly diploid (p = 0.01). There was no association between DNA ploidy and survival or aggressive behaviour of the tumour as indicated for example by advanced clinical stage or unfavourable histology. While DNA ploidy correlated with age, it did not correlate with any other clinical characteristic. The apparent lack of prognostic value of DNA content may have been masked by some high CV values and overridden by the effect of chemotherapy which was the most significant variable in determining a patient's survival (p = 0.00005).
Dias
P
P
Christie Hospital, Manchester, United Kingdom.
Kumar
P
P
Marsden
H B
HB
Gattamaneni
H R
HR
Kumar
S
S
D000782:Aneuploidy; D002648:Child; D004273:DNA, Neoplasm / Q000032:analysis*; D004171:Diploidy; D005260:Female; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D012208:Rhabdomyosarcoma / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D012509:Sarcoma / Q000235:genetics* / Q000401:mortality / Q000473:pathology
D004273:DNA, Neoplasm