[Effect of cefclidin and E1077, new cephalosporins, on the alcohol-metabolizing system in rats].
Administration of latamoxef and cefoperazone, reported to act like disulfiram in humans, caused a depression of mitochondrial low Km aldehyde dehydrogenase (low Km ALDH) activity in rats. In addition, a marked increase of blood acetaldehyde concentration was observed when rats were given alcohol orally at 18 hours after administration of these cephalosporins. However, mitochondrial low Km ALDH activity and blood acetaldehyde level were not altered by repeated administration of 300 mg and 1,000 mg of cefclidin (CFCL, E1040) or E1077 per kg. From these results, it was concluded that neither CFCLn or E1077 affected the alcohol metabolizing-system.
Watanabe
N
N
Tsukuba Research Laboratories, Eisai Co. Ltd.
Asakawa
N
N
Toyosawa
T
T
Hiruma
R
R
Hata
K
K
Ueno
J
J
Katsu
K
K
Yoshida
Y
Y
D000079:Acetaldehyde / Q000097:blood; D000444:Aldehyde Dehydrogenase / Q000378:metabolism*; D000818:Animals; D002511:Cephalosporins / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D000431:Ethanol / Q000493:pharmacokinetics*; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains
D002511:Cephalosporins; C075377:cefluprenam; D000431:Ethanol; C056494:cefclidin; D000444:Aldehyde Dehydrogenase; D000079:Acetaldehyde