title: Superior vena cava obstruction in a patient with chronic lymphocytic leukemia and lung cancer.
abstract: A patient with cervical lymphadenopathy secondary to chronic lymphocytic leukemia (CLL) developed acute superior vena cava (SVC) obstruction. Poor response to chemotherapy, a history of smoking, and lobar atelectasis suggested a different diagnosis. Bronchoscopy established the presence of a bronchogenic adenocarcinoma of the right lung as the etiology of the obstruction. Based on our experience and a review of the literature, we recommend that if a patient with CLL or a diffuse well-differentiated lymphocytic lymphoma presents with or develops SVC obstruction, additional invasive diagnostic tests must be initiated to exclude the possibility of a coexistent second malignancy or a transformation to a higher grade lymphoma. Other features warranting a search for another diagnosis are lack of the expected response to glucocorticoids, chemotherapy, or radiation therapy.
authors.affiliation: Department of Medical Oncology, Miami Veterans Affairs Medical Center, FL.
authors.forename: J A
authors.initials: JA
authors.lastname: de Mayolo
authors.forename: K S
authors.initials: KS
authors.lastname: Sridhar
authors.forename: B
authors.initials: B
authors.lastname: Kunhardt
authors.forename: R K
authors.initials: RK
authors.lastname: Rao
mesh_terms: D000230:Adenocarcinoma / Q000150:complications*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications*; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D013479:Superior Vena Cava Syndrome / Q000209:etiology*