title: The distribution of immunoreactive interferon-gamma-containing cells in normal human tissues.
abstract: An immunohistochemical technique has been used to study the distribution of lymphocytes expressing interferon-gamma in normal adult tissues. The greatest concentrations of these cells were seen in mucosal sites exposed to a resident microflora. It is proposed that such organisms, by eliciting immune responses, provide the stimulus for the production of 'physiological' interferon-gamma. This in turn may act to preserve the 'tone' or readiness of the immune system.
authors.affiliation: Department of Pathology, Glasgow Royal Infirmary, U.K.
authors.forename: F
authors.initials: F
authors.lastname: Brett
authors.forename: A
authors.initials: A
authors.lastname: Mowat
authors.forename: M A
authors.initials: MA
authors.lastname: Farquharson
authors.forename: M
authors.initials: M
authors.lastname: McGill
authors.forename: C
authors.initials: C
authors.lastname: Hind
authors.forename: J
authors.initials: J
authors.lastname: Richmond
authors.forename: D
authors.initials: D
authors.lastname: Murray
authors.forename: N U
authors.initials: NU
authors.lastname: Khan
authors.forename: A K
authors.initials: AK
authors.lastname: Foulis
mesh_terms: D000328:Adult; D004064:Digestive System / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D007371:Interferon-gamma / Q000032:analysis* / Q000276:immunology; D007413:Intestinal Mucosa / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D008221:Lymphoid Tissue / Q000276:immunology; D014566:Urogenital System / Q000276:immunology
chemical_list: D007371:Interferon-gamma