[Experimental study on repair of the defect of the pars interarticularis in rat with bone morphogenetic protein and fibrin glue].
The possibility of repairing the defect of the pars interarticularis (pars defect) with Bone Morphogenetic Protein (BMP) and fibrin glue was studied. The pars defect established in the 5th lumbar vertebra of Wistar rat was treated with surgical implantation of a composite consisting of BMP, fibrin glue and autologous cancellous bone. At 3, 6, 9 and 12 weeks after implantation, the osteoinductive activity in the pars defect was observed histologically and compared with that of other composite implants such as BMP with fibrin glue, autologous cancellous bone alone and autologous cancellous bone with fibrin glue. Although perfect bone fusion was not obtained with any of the composites employed, a significant increase in bone formation was seen in a composite of BMP, fibrin glue and autologous cancellous bone (p less than 0.01) as compared with that seen in the others. Consequently, implantation of BMP and fibrin glue combined with some biomaterials which support osteo-induction of BMP and stabilize the pars defect might be successfully applied to repair the pars defect.
Nakamura
T
T
Department of Orthopedic Surgery, School of Medicine, Tokushima University, Japan.
D000818:Animals; D019485:Bone Morphogenetic Proteins; D001861:Bone Regeneration; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006133:Growth Substances / Q000627:therapeutic use*; D008159:Lumbar Vertebrae / Q000002:abnormalities / Q000187:drug effects*; D008297:Male; D011506:Proteins / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
D019485:Bone Morphogenetic Proteins; D015718:Fibrin Tissue Adhesive; D006133:Growth Substances; D011506:Proteins