[Alterations in lymphocyte subsets in variable immunodeficiency syndrome].
Besides functional defects, different phenotypical alterations of lymphocytes have been described in patients with CVID. A decrease in LAM-1- (= Leu8) and CD21 expression was observed on B cells. Some patients with CVID show alterations in their T-cell subpopulations: The most striking features of this subgroup are low CD4/CD8-ratio, an increase in CD57/CD8 double-positive lymphocytes, and a strong enhancement of HLA-DR and "memory" markers such as CD29 and LFA-3 on T cells.
Baumert
E
E
Abteilung Rheumatologie und Klinische Immunologie, Medizinische Universitätsklinik, Freiburg.
Schlesier
M
M
Wolff-Vorbeck
G
G
Peter
H H
HH
D001402:B-Lymphocytes / Q000276:immunology; D016516:CD4-CD8 Ratio; D005434:Flow Cytometry; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D007156:Immunologic Memory; D007694:Killer Cells, Natural / Q000276:immunology; D016131:Lymphocyte Subsets / Q000276:immunology*; D009000:Monocytes / Q000276:immunology; D015375:Receptors, Interleukin-2 / Q000032:analysis; D013601:T-Lymphocytes / Q000276:immunology
D006684:HLA-DR Antigens; D015375:Receptors, Interleukin-2
Veränderungen von Lymphozyten-subpopulationen bei variablem Immundefektsyndrom.