[Molecular genetic, laboratory and clinical study of serum amyloid P].
Studying the gene polymorphism of serum amyloid P a common constituent of amyloid deposits two restriction fragment length polymorphism patterns were found among Hungarian rheumatoid arthritis (RA), juvenile rheumatoid arthritis (JRA), systemic lupus erythematosus (SLE) patients and healthy controls. Although no direct connection between DNA polymorphism and the frequency of amyloidosis in three patient groups was found, a marked predominance of the heterozygosity in all studied groups has been described. Authors found close correlation between the serum levels of SAP and CRP in juvenile rheumatoid arthritis, but failed to find the same correlation in SLE and healthy controls. Moreover, the serum level of CRP of heterozygous patients were significantly higher than that of homozygous patients within the juvenile rheumatoid arthritis patient groups.
Biró
J
J
Országos Reumatológiai Intézet, Budapest.
Balogh
Z
Z
Szongoth
M
M
Megyeri
A
A
Bély
M
M
Falus
A
A
D000682:Amyloid / Q000097:blood*; D001171:Arthritis, Juvenile / Q000097:blood* / Q000235:genetics / Q000276:immunology; D001327:Autoimmune Diseases / Q000097:blood* / Q000235:genetics / Q000276:immunology; D002097:C-Reactive Protein / Q000032:analysis; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000235:genetics / Q000276:immunology; D008967:Molecular Biology; D011110:Polymorphism, Genetic
D000682:Amyloid; D002097:C-Reactive Protein
Szérum amiloid P molekuláris genetikai, laboratóriumi és klinikai vizsgálata.