A comparative study of micronucleus frequency in peripheral blood lymphocytes of human subjects given dietary cis, trans and saturated fat.
The micronucleus test using peripheral blood lymphocytes has been used to study the clastogenic effects of saturated, cis or trans fatty acids in human volunteers. Consumption of diets rich in either saturated fats (palmitic acid), monounsaturated cis fats (oleic acid) or monounsaturated trans fats (elaidic acid) for 3 wk had no effect on either the number of micronuclei or the frequency of micronucleated cells in lymphocytes in culture. This study adds to the accumulating body of evidence to suggest that dietary intake of trans fatty acids is not especially linked to genetic damage.
Record
I R
IR
CSIRO Division of Human Nutrition, Adelaide, S. Australia.
Konstantinopoulos
M
M
Nestel
P J
PJ
D000328:Adult; D002849:Chromatography, Gas; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D015162:Micronucleus Tests; D008875:Middle Aged; D009829:Oleic Acids / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D010169:Palmitic Acids / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D013237:Stereoisomerism
D004041:Dietary Fats; D009829:Oleic Acids; D010169:Palmitic Acids