title: [24-hour blood pressure changes in elderly people with isolated systolic hypertension, essential hypertension and normotension].
abstract: In order to evaluate circadian blood-pressure (BP) profile characteristics typical of old age, we compared circadian BP profile in elderly subjects with isolated systolic hypertension (ISH; greater than 160/less than 90 mmHg), essential hypertension (EH; diastolic BP greater than or equal to 95 mmHg), and normotension (N; less than 140/less than 90 mmHg). Each group consisted of 18 subjects, approximately matched in age and sex, (age range 60-82 years; mean age 67.5 years). Ambulatory 24-h BP-monitoring was carried out using a SpaceLabs 90202 with measurements made every 30 min. In ISH, causal systolic BP is higher and circadian systolic BP is lower than in EH (n.s.). Circadian diastolic BP is lower than in EH and higher than in N; both are statistically highly significant (p less than 0.001, u-test, Wilcoxon). The decrease during the resting period is 6 mmHg in EH and 17 mmHg in ISH. In ISH there is a considerable difference of 39 mmHg between casual BP and circadian 24-h BP, in contrast to N and to EH, and this is due to a particular hyperreactivity. This discrepancy is typical of old age and holds the danger of over-treatment, if only causal BP is taken into consideration.
authors.affiliation: Institute of Cardiology and Clinical Research, Regensburg.
authors.forename: G
authors.initials: G
authors.lastname: Prager
authors.forename: R
authors.initials: R
authors.lastname: Prager
authors.forename: P
authors.initials: P
authors.lastname: Klein
authors.forename: S
authors.initials: S
authors.lastname: König
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000502:physiology; D015924:Blood Pressure Monitors; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012894:Sleep Stages / Q000502:physiology; D013599:Systole / Q000502:physiology*
vernacular_title: 24-Stunden-Blutdruckverhalten bei Senioren mit isoliertem systolischen Hypertonus, essentiellem Hypertonus und Normotonus.