title: Fluid balance in elderly patients following acute stroke.
abstract: We studied the relationship between plasma osmolality, arginine vasopressin (AVP), and fluid input in patients during the acute phase of a first stroke. Fifteen consecutive patients were studied (median age 79) and their blood sampled on days 0, 1, 2, 3, 7 and 14. Plasma osmolality was related to fluid input over days 0-3 (p = 0.0013) and AVP over 14 days (p less than 0.001). Patients with a poor outcome had higher AVP concentrations (p = 0.02). Those on intravenous fluids received a higher volume (p less than 0.01) and had a lower plasma osmolality (p = 0.04). The results of this preliminary study indicate that a standard regime for fluid input is inappropriate.
authors.affiliation: University Department of Geriatric Medicine, University Hospital of South Manchester.
authors.forename: P A
authors.initials: PA
authors.lastname: O'Neill
authors.forename: I
authors.initials: I
authors.lastname: Davies
authors.forename: K J
authors.initials: KJ
authors.lastname: Fullerton
authors.forename: D
authors.initials: D
authors.lastname: Bennett
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001127:Arginine Vasopressin / Q000097:blood; D002561:Cerebrovascular Disorders / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology*; D005260:Female; D006400:Hematocrit; D006801:Humans; D008297:Male; D009460:Neurologic Examination; D011379:Prognosis; D012964:Sodium / Q000097:blood; D015996:Survival Rate; D014882:Water-Electrolyte Balance / Q000502:physiology*
chemical_list: D001127:Arginine Vasopressin; D012964:Sodium