[Blood lipids in patients after kidney transplantation].
In 50 kidney transplant patients [KTP] [37 of them were treated by cyclosporine A and prednisone--CyA group while 13 of them by azathioprine + prednisone--Aza group] serum levels of total cholesterol, LDL-cholesterol, HDL--cholesterol and triglyceride et different time intervals during the first three years after transplantation. The control group comprised 20 healthy subjects. KTP were characterized by significantly elevated plasma levels of total cholesterol, LDL-cholesterol and triglycerides. In KTP treated by CyA+prednisone even an increase of plasma total cholesterol and LDL-cholesterol and a transitory decline of HDL--cholesterol were found as compared with respective basal values. From results obtain in this study it follows, that kidney transplantation does not normalize the lipid profile in KTP, and that KTP treated by CyA are characterized by more marked lipid abnormalities than those on azathioprine therapy. Time after successful kidney transplantation does influence significantly the lipid index of KTP.
Grzeszczak
W
W
Katedry i Kliniki Chorób Wewnetrznych, Zawodowych Slaskiej Akademii Medycznej, Zabrzu.
Kokot
F
F
Bar
A
A
Darocha
Z
Z
D000293:Adolescent; D000328:Adult; D001379:Azathioprine / Q000008:administration & dosage; D002784:Cholesterol / Q000097:blood*; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D006937:Hypercholesterolemia / Q000139:chemically induced / Q000209:etiology*; D015228:Hypertriglyceridemia / Q000139:chemically induced / Q000209:etiology*; D016030:Kidney Transplantation / Q000009:adverse effects / Q000502:physiology*; D008875:Middle Aged; D011182:Postoperative Care; D011183:Postoperative Complications / Q000139:chemically induced / Q000209:etiology*; D011241:Prednisone / Q000008:administration & dosage; D013997:Time Factors; D014280:Triglycerides / Q000097:blood*
D014280:Triglycerides; D016572:Cyclosporine; D002784:Cholesterol; D001379:Azathioprine; D011241:Prednisone
Badania nad lipemia u chorych z przeszczepiona nerka.