title: Flow cytometric DNA analysis of vascular soft tissue tumors, including African endemic-type Kaposi's sarcoma.
abstract: Vascular tumors of the soft tissue display a wide spectrum of histologic features and biologic behavior. Flow cytometric DNA analysis was performed on 40 vascular tumors, including nine African endemic-type Kaposi's sarcomas, nine angiosarcomas, seven hemangiopericytomas, six glomus tumors, and nine capillary hemangiomas. Six of the nine angiosarcoma cases (67%) and one of the seven hemangiopericytomas cases (14%) were aneuploid. All benign vascular tumors and Kaposi's sarcomas were diploid. Clinically, five of the six angiosarcoma patients with aneuploidy died within 2 to 28 months, while the remaining patient, who had the smallest tumor (2 x 1 cm), survived more than 4 years after the initial diagnosis was made. All three angiosarcoma patients with diploidy died within 10 to 14 months. One hemangiopericytoma patient with aneuploidy died within 1 month. No cases of benign tumor recurred. These results suggest that most vascular tumors, which generally follow a benign clinical course, were diploid and that the majority of those with a poor outcome were aneuploid. However, flow cytometrically assessed DNA ploidy has no prognostic value in angiosarcomas or hemangiopericytomas.
authors.affiliation: Department of Pathology, Nagasaki University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Eto
authors.forename: K
authors.initials: K
authors.lastname: Toriyama
authors.forename: N
authors.initials: N
authors.lastname: Tsuda
authors.forename: Y
authors.initials: Y
authors.lastname: Tagawa
authors.forename: H
authors.initials: H
authors.lastname: Itakura
mesh_terms: D000293:Adolescent; D000328:Adult; D001808:Blood Vessels / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D004273:DNA, Neoplasm / Q000032:analysis*; D005434:Flow Cytometry; D006393:Hemangiopericytoma / Q000098:blood supply / Q000235:genetics; D006394:Hemangiosarcoma / Q000098:blood supply / Q000235:genetics; D006801:Humans; D007223:Infant; D008875:Middle Aged; D012514:Sarcoma, Kaposi / Q000098:blood supply / Q000145:classification / Q000235:genetics*; D012983:Soft Tissue Neoplasms / Q000098:blood supply / Q000235:genetics*
chemical_list: D004273:DNA, Neoplasm