Biological effects of tolytoxin (6-hydroxy-7-O-methyl-scytophycin b), a potent bioactive metabolite from cyanobacteria.
Tolytoxin, a macrocyclic lactone, is a potent antifungal antibiotic, exhibiting MICs in the range of 0.25 to 8 nanomolar. Tolytoxin also inhibits the growth of a variety of mammalian cells at similar doses, without specific inhibition of macromolecular synthesis. The effects in mammalian cells are primarily cytostatic, with cell death being time- and dose-dependent. Tolytoxin is highly toxic to mice, exhibiting an LD50 (ip) of 1.5 mg/kg. No antibacterial, antiviral, or hemolytic activities were observed.
Patterson
G M
GM
Department of Chemistry, University of Hawaii, Honolulu 96822.
Carmeli
S
S
D000818:Animals; D000935:Antifungal Agents / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D000458:Cyanobacteria / Q000737:chemistry / Q000378:metabolism*; D005260:Female; D006131:Growth Inhibitors / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D006461:Hemolysis / Q000187:drug effects; D008297:Male; D051379:Mice; D011714:Pyrans / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains
D000935:Antifungal Agents; D006131:Growth Inhibitors; D011714:Pyrans; C068527:tolytoxin