Interference with ovulation and luteal function by human ovarian follicular fluid peptide in bonnet monkeys, Macaca radiata.
Partially purified human ovarian follicular fluid peptide (hGF2) was administered during follicular phase in 5 bonnet monkeys. In control as well as hGF2-injected animals, ovulation was synchronized by treatment with FSH, Pergonal and hCG. All the 5 control bonnet monkeys showed plasma estradiol peak followed by increased progesterone levels. In 4 out of 5 hGF2-injected animals, plasma progesterone levels were drastically reduced. Plasma estradiol levels were decreased only in 3 animals in which amenorrhea was observed. These data reveal that hGF2 injection disrupted ovarian function in bonnet monkeys.
Nandedkar
T D
TD
Institute for Research in Reproduction, Parel, Bombay, India.
Shahid
J K
JK
Kholkute
S D
SD
Darpe
M B
MB
Moodbidri
S B
SB
D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects*; D004958:Estradiol / Q000097:blood; D005260:Female; D007273:Injections, Intramuscular; D036341:Intercellular Signaling Peptides and Proteins; D008255:Macaca radiata; D008597:Menstrual Cycle / Q000187:drug effects; D010060:Ovulation / Q000187:drug effects*; D010455:Peptides / Q000494:pharmacology*; D011374:Progesterone / Q000097:blood
D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C018355:intraovarian peptides; D011374:Progesterone; D004958:Estradiol