title: [The possibilities for the early diagnosis of ankylosing spondylarthritis].
abstract: Soluble antigen HLA-B27 was assayed in blood serum of 30 patients afflicted with ankylosing spondyloarthritis (AS) and 25 healthy subjects having HLA-B27 (B27+) antigen in the phenotype. As compared to B27+ healthy subjects, B27+ patients with AS demonstrated a significantly higher level of soluble HLA-B27 antigen. A substance whose functional activity was found to be identical to that of soluble HLA-B27 antigen in blood serum of B27- patients with AS was discovered for the first time. It was absent from B27- healthy subjects. In addition to the identification of the fixed forms of soluble HLA-B27 antigen, the assay of this antigen in blood serum enhances the potentialities of laboratory diagnosis of AS, which plays an important role at the early disease stages.
authors.forename: G P
authors.initials: GP
authors.lastname: Matveĭkov
authors.forename: V I
authors.initials: VI
authors.lastname: Levin
authors.forename: I P
authors.initials: IP
authors.lastname: Titova
authors.forename: E S
authors.initials: ES
authors.lastname: Kaliia
authors.forename: A N
authors.initials: AN
authors.lastname: Soloveĭ
authors.forename: L G
authors.initials: LG
authors.lastname: Atamanenko
mesh_terms: D000328:Adult; D002908:Chronic Disease; D005260:Female; D015796:HLA-B27 Antigen / Q000097:blood; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012995:Solubility; D013167:Spondylitis, Ankylosing / Q000175:diagnosis*; D013997:Time Factors
chemical_list: D015796:HLA-B27 Antigen
vernacular_title: Vozmozhnosti ranneĭ diagnostiki ankiloziruiushchego spondiloartrita.