Obstructive jaundice secondary to primary biliary involvement with Hodgkin's disease.
A 41-yr-old man presented with jaundice, night sweats, and weight loss. The patient had been on phenytoin for seizure disorder. The drug was discontinued, and a diminution of bilirubin and transaminases occurred over several weeks. Percutaneous liver biopsy revaled cholestasis at the time of maximal hyperbilirubinemia. Recurrent jaundice ensued several weeks later, and an ERCP revealed a common bile duct lesion. Laparotomy revealed Hodgkin's disease involving the common bile duct and periportal node. This cause represents the first report of extrahepatic biliary obstruction from Hodgkin's disease.
Martin
K R
KR
Department of Medicine, University of Louisville School of Medicine, Kentucky.
Moore
T J
TJ
Wright
R A
RA
D000328:Adult; D001649:Bile Duct Diseases / Q000150:complications* / Q000473:pathology; D001651:Cholestasis, Extrahepatic / Q000209:etiology*; D006689:Hodgkin Disease / Q000150:complications*; D006801:Humans; D016246:Lymphocytes, Tumor-Infiltrating / Q000473:pathology*; D008297:Male