title: Low dose preoperative radiotherapy for carcinoma of the oesophagus: results of a randomized clinical trial.
abstract: One-hundred-and-seventy-six patients with potentially operable squamous cell carcinoma or adenocarcinoma of the middle or lower thirds of the oesophagus were randomly assigned to preoperative radiotherapy or surgery alone. Patients assigned to the radiotherapy arm received 20 Gy in 10 treatments over 2 weeks, using parallel opposed 4 MV beams. The preoperative radiotherapy was not associated with any significant acute morbidity or any increase in operative complications. The median survival of the overall group of 176 patients was 8 months, and the 5-year survival was 13%. There was no significant difference in the survival of the 90 patients who received preoperative radiotherapy and the 86 who were managed by surgery alone. Proportional hazards analysis identified lymph node involvement, high tumour grade and male sex as significant adverse prognostic features, but the treatment option assigned had no prognostic significance. It was concluded that low dose preoperative radiotherapy offered no advantage over surgery alone.
authors.affiliation: Department of Clinical Oncology, Western General Hospital, Scotland, UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: Arnott
authors.forename: W
authors.initials: W
authors.lastname: Duncan
authors.forename: G R
authors.initials: GR
authors.lastname: Kerr
authors.forename: P R
authors.initials: PR
authors.lastname: Walbaum
authors.forename: E
authors.initials: E
authors.lastname: Cameron
authors.forename: W J
authors.initials: WJ
authors.lastname: Jack
authors.forename: W J
authors.initials: WJ
authors.lastname: Mackillop
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000532:radiotherapy* / Q000601:surgery; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000532:radiotherapy* / Q000601:surgery; D016629:Esophagectomy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011879:Radiotherapy Dosage; D012606:Scotland / Q000453:epidemiology; D016019:Survival Analysis