Tirandalydigin, a novel tetramic acid of the tirandamycin-streptolydigin type. I. Taxonomy of the producing organism, fermentation and biological activity.
Tirandalydigin is a new tetramic acid antibiotic which was discovered in a screen designed to find compounds with activity against pathogenic anaerobic bacteria. It was named tirandalydigin because it possesses structural features that are common to both tirandamycin and streptolydigin. The producing culture, strain AB 1006A-9, is a Streptomyces and was compared to the streptomycetes that synthesize tirandamycin and streptolydigin. It is closely related to the former culture and was named Streptomyces tirandis subsp. umidus. Tirandalydigin has MICs in the range of 0.5 to 32 micrograms/ml against many pathogenic anaerobes, streptococci, enterococci and legionellae.
Karwowski
J P
JP
Pharmaceutical Products Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064.
Jackson
M
M
Theriault
R J
RJ
Barlow
G J
GJ
Coen
L
L
Hensey
D M
DM
Humphrey
P E
PE
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D013302:Streptomyces / Q000145:classification*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C055113:tirandalydigin; C003608:tirandamycin A; C100307:streptolydigin