title: Herboxidiene, a new herbicidal substance from Streptomyces chromofuscus A7847. Taxonomy, fermentation, isolation, physico-chemical and biological properties.
abstract: Screening of microbial fermentation broths for herbicidal activity led to the discovery of a novel polyketide, herboxidiene, from an actinomycete identified as a member of the Streptomyces chromofuscus cluster. A 14- to 20-fold increase in fermentation production of herboxidiene was achieved as a result of media optimization. Herboxidiene was purified using successive reverse phase C18 steps and Sephadex LH-20 chromatography. Its molecular formula, C25H42O6, was determined by HRFAB-MS. Herboxidiene demonstrated exceptionally potent, selective, herbicidal activity against a variety of weed species and was inactive against wheat, even at rates as high as 5.6 kg/hectare.
authors.affiliation: Monsanto Agricultural Company, Monsanto Company, Chesterfield, Missouri 63198.
authors.forename: M
authors.initials: M
authors.lastname: Miller-Wideman
authors.forename: N
authors.initials: N
authors.lastname: Makkar
authors.forename: M
authors.initials: M
authors.lastname: Tran
authors.forename: B
authors.initials: B
authors.lastname: Isaac
authors.forename: N
authors.initials: N
authors.lastname: Biest
authors.forename: R
authors.initials: R
authors.lastname: Stonard
mesh_terms: D003470:Culture Media; D005233:Fatty Alcohols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D006540:Herbicides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000145:classification / Q000378:metabolism
chemical_list: D003470:Culture Media; D005233:Fatty Alcohols; D006540:Herbicides; D011714:Pyrans; C076087:herboxidiene