Photooxidation products of merocyanine 540 formed under preactivation conditions for tumor therapy.
In order to gain insight into the preactivation of merocyanine 540 (MC540) 1 for the photodynamic therapy (Gulliya et al., 1990a, Photochem. Photobiol. 52, 831-838) its photo-oxidation was investigated. After irradiation of MC540 1 on a preparative scale three main photodegradation products were isolated with 16-20% yields. They turned out to be derivatives of benzoxazole, thiouracil and thiohydantoin with the structures 4, 5 and 6, respectively. It may be possible that they contribute to the cytostatic and antiviral activity of preactivated MC540 1.
Franck
B
B
Organisch-Chemisches Institut, Universität Münster, Germany.
Schneider
U
U
D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010777:Photochemistry; D010778:Photochemotherapy; D011744:Pyrimidinones / Q000737:chemistry / Q000528:radiation effects*; D011838:Radiation-Sensitizing Agents / Q000737:chemistry / Q000528:radiation effects
D011744:Pyrimidinones; D011838:Radiation-Sensitizing Agents; C003954:merocyanine dye