title: Cardiotoxicity of the skin of the red-banded rubber frog, Phrynomerus bifasciatus (Smith 1847).
abstract: The skin of the red-banded rubber frog is said to secrete an unidentified toxin. Whole skin extract as well as HPLC fractions were tested for toxicity on viable, isolated cardiomyocytes. The skin extract and one of its fractions were shown to be cardiotoxic. Whole-cell clamping tests demonstrated that both extract and fraction interfered with the function of the potassium channels of the cardiomyocytes and that the toxic substance has an affinity for the IK, channels. Investigations are in progress to isolate and characterize the toxic substance.
authors.affiliation: Department of Biochemistry, University for Christian Higher Education, Potchefstroom, Republic of South Africa.
authors.forename: M P
authors.initials: MP
authors.lastname: Van Der Walt
authors.forename: J M
authors.initials: JM
authors.lastname: Van Rooyen
authors.forename: G
authors.initials: G
authors.lastname: Oberholzer
authors.forename: G
authors.initials: G
authors.lastname: Van Aswegen
mesh_terms: D000664:Amphibian Venoms / Q000494:pharmacology*; D000818:Animals; D001001:Anura / Q000378:metabolism*; D002478:Cells, Cultured; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D012867:Skin / Q000737:chemistry*
chemical_list: D000664:Amphibian Venoms