title: [Detergent enzymes: has the risk of occupational sensitization disappeared?].
abstract: Occupational allergy to enzyme detergents had almost disappeared by the use of preventive measures, both individually and in industries. The occurrence of 8 new cases of asthma in a detergent factory has led to a prospective clinical and aetiological enquiry. Although there was no documentation using the specific provocation test or by measuring respiratory function whilst at work, the occupational character of this asthma seemed possible after taking a history. Sensitization to the enzymes used (Savinase, Maxatase and Biozym P 300 S) was shown by skin tests (8 positive to all the enzymes) and the level of specific IgE to Rast (8 times greater than class 3 for Savinase and Maxitase) and for HBDT for Maxatase and Biozym P 300 S (greater than 50% in 8 patients). From another stand point the incomplete application of preventive measures within the factory did not seem to totally explain the origin of this sensitization. In fact, it was the study of the morphology of the enzyme grains, which had been introduced into the factory which helped us to explain the mechanism. In effect it was the capsules of the grain which were fissured and thus allowed allergen contact. The replacement of these grains whose envelope was intact, led to the disappearance of the symptoms and confirmed our hypothesis. There remains a continuing risk from occupational sensitization to asthma and it is suggested that there is continued collaboration between the medical profession and industry.
authors.affiliation: Clinique des Maladies Respiratoires et Allergiques, CHR de Reims, Hôpital Maison-Blanche.
authors.forename: D
authors.initials: D
authors.lastname: Perdu
authors.forename: F
authors.initials: F
authors.lastname: Lavaud
authors.forename: C
authors.initials: C
authors.lastname: Cossart
authors.forename: S
authors.initials: S
authors.lastname: Legrele
authors.forename: F
authors.initials: F
authors.lastname: Passemard
authors.forename: G
authors.initials: G
authors.lastname: Deltour
authors.forename: J M
authors.initials: JM
authors.lastname: Dubois de Montreynaud
mesh_terms: D000328:Adult; D001249:Asthma / Q000139:chemically induced*; D003902:Detergents / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000175:diagnosis; D010447:Peptide Hydrolases / Q000009:adverse effects*; D011852:Radioallergosorbent Test; D012882:Skin Tests
chemical_list: D003902:Detergents; D010447:Peptide Hydrolases
vernacular_title: Enzymes des lessives: le risque de sensibilisation professionnelle a-t-il disparu?