title: [Myocardial contrast echocardiography for the follow-up after percutaneous transluminal coronary angioplasty].
abstract: Myocardial contrast echocardiography was performed, before and after successful elective percutaneous transluminal angioplasty (PTCA) of a main coronary artery, in 35 patients (31 men, 4 women; mean age 56 +/- 6 years). After intracoronary injection of microbubbles-containing 2 ml iopromide, contrast half-life (t/2) and maximal echo-intensity (Imax) in the myocardial region supplied by the target vessel were measured. While t/2 decreased from 8.3 +/- 5.4 s to 5.7 +/- 3.3 s (P less than 0.0002), mean Imax remained unchanged (27.4 +/- 10.7 vs 26.1 +/- 10.1 grey value units). Repeat cardiac catheterization with contrast echocardiography was performed a mean of 37 weeks (7-53) later in 13 of 35 patients with optimal echo image quality. Re-stenosis of at least 75% was demonstrated in six patients, while in seven vessel diameter had decreased by less than 30%. In all patients with re-stenosis t/2 had increased by about 20 to 100% of the initial value. It was always over 5 s (mean 6.2 +/- 1.6 s before, 4.7 +/- 1.7 after PTCA, and 6.2 +/- 1.2 s at the end of the follow-up). In one patient a prolonged t/2 persisted due to vessel dissection. Mean t/2 remained unchanged in patients without re-stenosis (5.6 +/- 2.1 s before, 3.5 +/- 1.15 s immediately after PTCA, and 3.6 +/- 1.25 s at the follow-up examination). These data suggest that contrast half-life is suitable for demonstrating changes in myocardial perfusion after PTCA.
authors.affiliation: Medizinische Klinik, Universität München.
authors.forename: H
authors.initials: H
authors.lastname: Mudra
authors.forename: V
authors.initials: V
authors.lastname: Klauss
authors.forename: J
authors.initials: J
authors.lastname: Metz
authors.forename: O
authors.initials: O
authors.lastname: Meissner
authors.forename: W
authors.initials: W
authors.lastname: Zwehl
authors.forename: K
authors.initials: K
authors.lastname: Theisen
mesh_terms: D000787:Angina Pectoris / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000628:therapy; D015906:Angioplasty, Balloon, Coronary / Q000706:statistics & numerical data; D003287:Contrast Media / Q000008:administration & dosage; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000628:therapy; D004452:Echocardiography / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D005500:Follow-Up Studies; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D007472:Iohexol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D011877:Radionuclide Imaging; D012008:Recurrence; D013794:Thallium Radioisotopes
chemical_list: D003287:Contrast Media; D013794:Thallium Radioisotopes; D007472:Iohexol; C038192:iopromide
vernacular_title: Myokardiale Kontrastechokardiographie zur Verlaufskontrolle nach perkutaner transluminaler Koronarangioplastie.