Neonatal alloimmune thrombocytopenia due to anti-P1A1 (anti-HPA-1a): importance of paternal and fetal platelet typing for assessment of fetal risk.
Neonatal alloimmune thrombocytopenia (NAIT), which usually involves sensitization to P1A1 (HPA-1a), may have devastating complications for the fetus. These may be prevented by antenatal treatment of severe cases with either maternally administered high-dose gamma-globulin and/or repeated intrauterine platelet transfusions. Determination of the paternal platelet phenotype is useful for counseling parents who have had one or more affected pregnancies. This report of an unaffected pregnancy in a woman with a history of previous pregnancies complicated by NAIT illustrates the role of paternal and fetal platelet phenotyping in managing existing pregnancies at risk of NAIT.
Lipitz
S
S
Fetal Medicine Unit, University College Hospital, London, U.K.
Ryan
G
G
Murphy
M F
MF
Robson
S C
SC
Haeusler
M C
MC
Metcalfe
P
P
Kelsey
H
H
Rodeck
C H
CH
D000328:Adult; D016824:Antigens, Human Platelet / Q000032:analysis*; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000628:therapy; D016913:Blood Component Transfusion; D001792:Blood Platelets / Q000276:immunology*; D005260:Female; D005312:Fetal Blood / Q000166:cytology; D005315:Fetal Diseases / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D016130:Immunophenotyping; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011296:Prenatal Diagnosis; D012306:Risk; D013921:Thrombocytopenia / Q000175:diagnosis* / Q000628:therapy
D016824:Antigens, Human Platelet