T cell tolerance after bone marrow transplantation in mice.
This article provides a brief overview of T cell tolerance induction in the thymus, using parent----F1 bone marrow (BM) chimeras as a model. Although intrathymic tolerance is controlled largely by BM-derived cells, experiments with BM chimeras suggest that thymic epithelial cells can make a major contribution to tolerance induction, especially for high-affinity T cells. Whether extrathymic mechanisms contribute to tolerance induction remains controversial: evidence against this possibility is provided by the finding that transferring normal parental strain T cells to parent----F1 chimeras leads to immunogenicity rather than tolerogenicity. Breakdown of self tolerance is discussed in terms of the phenomenon of "auto-GVHD".
Sprent
J
J
Scripps Research Institute, La Jolla, California.
Kosaka
H
H
Gao
E K
EK
D000818:Animals; D015551:Autoimmunity; D016026:Bone Marrow Transplantation / Q000276:immunology*; D015704:CD4 Antigens; D016827:CD8 Antigens; D002678:Chimera; D007108:Immune Tolerance; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*
D015704:CD4 Antigens; D016827:CD8 Antigens