[Computer simulation of blood level profiles. Drug liberation from two sustained-release preparations and computer simulation of single- and multiple-dose pharmacokinetics].
A series of computer programs (BASIC) is introduced for the evaluation of in vitro dissolution data as well as for the calculation of pharmacokinetic parameters and for blood level curve fitting to the respective in vitro data. Furthermore, programs are offered for the simulation of blood level profiles under variable conditions. In order to demonstrate the practical use of these programs, the expected blood level profiles following the administration of two commercial sustained-release dosage forms containing the drug pentoxifylline have been compared.
Koch
H P
HP
Institut für Pharmazeutische Chemie Universität Wien, Osterreich.
D003198:Computer Simulation; D003692:Delayed-Action Preparations; D006801:Humans; D007408:Intestinal Absorption; D008954:Models, Biological; D010431:Pentoxifylline / Q000097:blood / Q000493:pharmacokinetics; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D010599:Pharmacokinetics; D012984:Software
D003692:Delayed-Action Preparations; D004364:Pharmaceutical Preparations; D010431:Pentoxifylline
Computersimulation von Blutspiegelprofilen. Wirkstoffliberation aus zwei Retardpräparaten und Computer-Simulation der Ein- und Mehrdosen-Pharmakokinetik.