title: Dermatonecrotic lesions in rabbits caused by neuraminidase.
abstract: In an attempt to study the role of neuraminidase in cholera vibrio pathogenesis, the dermatonecrotic effect of a purified neuraminidase preparation was studied in rabbits. The experiments demonstrated that dermatonecrotic lesions resulted from intracutaneous injection of a purified neuraminidase preparation (0.5 specific human dose or 1 NU) as well as significant doses of cholera toxoid containing the enzyme (4,12,18 specific human doses).
authors.affiliation: Department of Pathohistology, Russian State Antiplague Research Institute, Microbe, Saratov.
authors.forename: I V
authors.initials: IV
authors.lastname: Isupov
authors.forename: O F
authors.initials: OF
authors.lastname: Sagheyeva
authors.lastname: Yeliseyev YuYu
authors.forename: A K
authors.initials: AK
authors.lastname: Adamov
authors.forename: L V
authors.initials: LV
authors.lastname: Sayapina
authors.forename: N M
authors.initials: NM
authors.lastname: Kovalenko
authors.forename: O I
authors.initials: OI
authors.lastname: Lukyanova
mesh_terms: D000818:Animals; D002772:Cholera Toxin; D005260:Female; D007279:Injections, Subcutaneous; D008297:Male; D009336:Necrosis / Q000209:etiology; D009439:Neuraminidase / Q000633:toxicity*; D011817:Rabbits; D012867:Skin / Q000187:drug effects / Q000473:pathology*; D014121:Toxoids / Q000633:toxicity*
chemical_list: D014121:Toxoids; C038458:cholera toxoid; D002772:Cholera Toxin; D009439:Neuraminidase