title: [Long-term follow-up of Crohn disease].
abstract: 184 patients diagnosed with Crohn's disease were observed for an average of 5 years and evaluated for clinical pattern and course of disease. The male/female ratio was almost equal (90 m. vs. 94 f.). The peak of disease manifestation was between years 18-32. Familial clustering of inflammatory bowel disease was observed in 2.2%. The pattern of anatomic involvement was ileocolic in 53%, colon in 24%, small bowel in 20% and other locations in 3%. 34% of patients were afflicted with at least one extraintestinal manifestation, 34% developed fistulae. Fistula formation was seen more often in colon involvement than small bowel involvement (69% vs. 32%). 48% of the patients were operated at least once. 3 patients died during the observation period, 2 of them with sepsis. Evolution of carcinoma was not observed. Some of our results are in accordance with the literature, some distinct observations (e.g. low familial clustering) underline the theory of a multifactorial pathogenesis in Crohn's disease.
authors.affiliation: II. Universitätsklinik für Gastroenterologie und Hepatologie, Universität Wien, Osterreich.
authors.forename: M
authors.initials: M
authors.lastname: Stetter
authors.forename: E
authors.initials: E
authors.lastname: Schuster
authors.forename: P
authors.initials: P
authors.lastname: Knoflach
mesh_terms: D000038:Abscess / Q000175:diagnosis / Q000401:mortality / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D003424:Crohn Disease / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007412:Intestinal Fistula / Q000175:diagnosis / Q000401:mortality / Q000473:pathology; D007413:Intestinal Mucosa / Q000473:pathology; D007415:Intestinal Obstruction / Q000175:diagnosis / Q000401:mortality / Q000473:pathology; D007416:Intestinal Perforation / Q000175:diagnosis / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015996:Survival Rate
vernacular_title: Langzeitverlauf des Morbus Crohn.