title: Moxidectin: systemic activity against common cattle grubs (Hypoderma lineatum) (Diptera: Oestridae) and trichostrongyle nematodes in cattle.
abstract: Moxidectin, a systemic insecticide, was evaluated for its efficacy against the migrating first instars of the common cattle grub, Hypoderma lineatum, and against nematode egg production in beef cattle. It was observed that all three levels (0.1, 0.2 and 0.4 mg moxidectin kg-1) were 100% effective against cattle grubs when administered as a s.c. injection. The same levels of treatment were very effective (90-100%) in reducing trichostrongyle nematode egg production. However, there was a slight indication that at least one species, Cooperia oncophora, was not completely eliminated, as it was observed that small numbers of eggs began to appear after 2 weeks post-treatment when there had been no opportunity for reinfection.
authors.affiliation: US Department of Agriculture, Knipling-Bushland US Livestock Insects Research Laboratory, Kerrville, TX 78029.
authors.forename: P J
authors.initials: PJ
authors.lastname: Scholl
authors.forename: F S
authors.initials: FS
authors.lastname: Guillot
authors.forename: G T
authors.initials: GT
authors.lastname: Wang
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000969:Antinematodal Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D005243:Feces / Q000469:parasitology; D005260:Female; D007000:Hypodermyiasis / Q000188:drug therapy / Q000662:veterinary*; D007279:Injections, Subcutaneous / Q000662:veterinary; D007306:Insecticides / Q000008:administration & dosage / Q000627:therapeutic use*; D018942:Macrolides; D008297:Male; D010058:Oviposition / Q000187:drug effects; D010270:Parasite Egg Count / Q000662:veterinary; D011897:Random Allocation; D014251:Trichostrongyloidea / Q000187:drug effects / Q000502:physiology; D014252:Trichostrongyloidiasis / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D000900:Anti-Bacterial Agents; D000969:Antinematodal Agents; D007306:Insecticides; D018942:Macrolides; C027837:moxidectin