[Autoimmune phenomena during Trypanosoma equiperdum inoculation of the laboratory mouse].
In the course of the Trypanosoma equiperdum-infection of mice an increase of IgM antibodies against the autoantigens dsDNA, keratin and collagen as well as against a protozoan foreign antigen consisting of Sarcocystis gigantea-extract could be observed with a maximum level between 4th and 8th day p. i. The IgG-antibodies did not significantly change during the investigation time. A splenomegaly appeared after the infection. The weight of spleen was four times higher than normal. It was suggested that splenomegaly as well as induction of antibodies against several autoantigens and a foreign antigen were due to a polyclonal activation of lymphocytes.
Jungnitz
S
S
Institut für Parasitologie, Veterinärmedizinischen Fakultät, Klinik für Innere Medizin, Theodor Brugsch, Humboldt-Universität, Berlin.
Hiepe
F
F
Kiessig
S T
ST
Jungmann
R
R
Hiepe
T
T
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000662:veterinary*; D051379:Mice / Q000469:parasitology*; D012376:Rodent Diseases / Q000276:immunology*; D014345:Trypanosoma / Q000276:immunology*; D014352:Trypanosomiasis / Q000276:immunology / Q000662:veterinary*
Autoimmunphänomene bei der Trypanosoma equiperdum-Inokulation der Labormaus.