[Chemotherapy-associated hemolytic uremic syndrome--a case report].
A 63-year-old male had undergone combination chemotherapy including adriamycin, cisplatin, mitomycin C, 5-fluorouracil and vindesine for six months for double cancer of esophagus and stomach. He complained of lassitude during therapy, and laboratory examinations revealed microangiopathic hemolytic anemia, thrombocytopenia and hyperbilirubinemia. Despite administration of prednisolone, dipyridamole and fresh frozen plasma, the patient died six days later. Postmortem examination disclosed multiple microthrombi in the liver, kidney and pancreas. It was presumed that MMC had caused the illness.
Kikuchi
H
H
Dept. of Clinical Cancer Chemotherapy, Tohoku University, Sendai, Japan.
Kanamaru
R
R
D000230:Adenocarcinoma / Q000188:drug therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004938:Esophageal Neoplasms / Q000188:drug therapy*; D005472:Fluorouracil / Q000008:administration & dosage; D006463:Hemolytic-Uremic Syndrome / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage / Q000009:adverse effects*; D009378:Neoplasms, Multiple Primary; D013274:Stomach Neoplasms / Q000188:drug therapy*; D014751:Vindesine / Q000008:administration & dosage
D016685:Mitomycin; D004317:Doxorubicin; D002945:Cisplatin; D014751:Vindesine; D005472:Fluorouracil