title: Functional studies of left upper quadrant mass aid management of idiopathic thrombocytopenic purpura.
abstract: ITP (idiopathic thrombocytopenic purpura) causes rapid sequestration and destruction of thrombocytes by the spleen, liver, bone marrow, and reticuloendothelial elements of other organs. The usefulness of multiple radionuclide functional imaging procedures in the management of a 34-year-old woman with chronic ITP, two splenectomies (removal of the initial spleen and then a hypertrophied accessory spleen), and the failure of chemotherapy to control her thrombocytopenia, are discussed. A combination of In-111 oxine autologous platelet imaging, liver/spleen imaging, disofenin (liver/gallbladder) imaging, and glucoheptonate renal imaging demonstrated that her platelets were being sequestered by a markedly enlarged left hepatic lobe extending to the left lateral wall, with a small amount in the kidneys and lungs, and that there was no second accessory spleen.
authors.affiliation: Nuclear Medicine Service, Bay Pines Veterans Administration Medical Center, Florida.
authors.forename: S J
authors.initials: SJ
authors.lastname: Harwood
authors.forename: R G
authors.initials: RG
authors.lastname: Carroll
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007098:Imino Acids; D007668:Kidney / Q000000981:diagnostic imaging / Q000503:physiopathology; D008099:Liver / Q000000981:diagnostic imaging / Q000503:physiopathology; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D015125:Oxyquinoline / Q000031:analogs & derivatives; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000000981:diagnostic imaging* / Q000503:physiopathology; D011877:Radionuclide Imaging; D013154:Spleen / Q000000981:diagnostic imaging / Q000503:physiopathology; D013400:Sugar Acids; D019785:Technetium Tc 99m Disofenin
chemical_list: D007098:Imino Acids; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D013400:Sugar Acids; C032950:indium oxine; D015125:Oxyquinoline; C100014:technetium Tc 99m gluceptate; D019785:Technetium Tc 99m Disofenin