Severe acute form of adult dermatomyositis treated with cyclosporine.
The classical treatment of severe forms of dermatomyositis includes high doses of steroids and/or cytotoxic agents. Acute forms are frequently life threatening. Because cyclosporine is a fast-acting immunosuppressive drug, it appears to be a good candidate for the treatment of refractory forms of acute dermatomyositis. We report a dramatic improvement of a severe, acute, steroid-resistant adult form after cyclosporine administration. A rapid clinical and biochemical improvement is reported, and the reversibility of immunologic abnormalities is emphasized.
Correia
O
O
Department of Dermatology, Oporto Medical School, Hospital S. João, Porto, Portugal.
Polónia
J
J
Nunes
J P
JP
Resende
C
C
Delgado
L
L
D000208:Acute Disease; D016572:Cyclosporine / Q000627:therapeutic use*; D003882:Dermatomyositis / Q000188:drug therapy*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D012720:Severity of Illness Index
D016572:Cyclosporine; D011239:Prednisolone