title: Distribution of fluoride in saliva and plaque fluid after a 0.048 mol/L NaF rinse.
abstract: An ultramicro method has recently been described for measurement of plaque-fluid fluoride concentration (Vogel et al., 1990a). This method was used: (1) for exploration of the variation in fluoride concentration of plaque fluid collected from the same buccal tooth sites following a 0.048 mol/L NaF (0.2%) rinse, and (2) for examination of the distribution of fluoride in plaque fluid and saliva within one hour after this rinse. Results indicated an average coefficient of variation (CV) of 31% for plaque-fluid fluoride in triplicate samples recovered simultaneously from the buccal-proximal region of two teeth after the rinse. This was similar to the CV found for plaque-fluid fluoride from the same sites after separate administrations of the rinse. A strong linear correlation was found between salivary and plaque-fluid fluoride at 30 and 60 min after rinse administration, showing that plaque-fluid fluoride is influenced by the concentration of salivary fluoride after administration of this rinse. Plaque-fluid fluoride concentrations were higher than that in saliva at baseline, 30, and 60 min. Very large inter-site and intersubject variations in plaque-fluid distribution were observed, with the central incisors showing the slowest clearance. These variations suggest that an examination of plaque-fluid fluoride from specific tooth regions may be essential for understanding the effects of fluoride on the site-specificity of caries.
authors.affiliation: American Dental Association Health Foundation, Paffenbarger Research Center, Polymers Division, Gaithersburg, Maryland.
authors.forename: G L
authors.initials: GL
authors.lastname: Vogel
authors.forename: C M
authors.initials: CM
authors.lastname: Carey
authors.forename: J
authors.initials: J
authors.lastname: Ekstrand
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D003773:Dental Plaque / Q000378:metabolism*; D005260:Female; D005459:Fluorides / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes; D012044:Regression Analysis; D012463:Saliva / Q000378:metabolism*; D012636:Secretory Rate; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D009067:Mouthwashes; D012969:Sodium Fluoride; D005459:Fluorides