title: [MRSA infections in the neonatal unit].
abstract: MRSA infection in the neonatal unit is discussed, presenting our experience of an epidemic of TSST-1-positive strains in the Teikyo University Hospital in 1988-1989. Neonatal MRSA infections were experienced for the first time in 1982, and a few cases were treated each year from 1984 to 1987. In October 1988, MRSA-colonized and/or diseased cases increased abruptly after admission of several MRSA-positive neonates. The new strains were TSST-1-positive, coagulase type II organisms, which were multiply resistant, including gentamicin. The disease/colonization ratio was 37.0% in 108 colonized neonates. Among them, 5 cases of atypical TSS were experienced. The main clinical manifestation was an abrupt onset of shock with leukopenia. Some of the cases were afebrile and rash was hard to recognise. For the successful treatment of neonatal TSS, not only effective antibiotics but also prompt exchange transfusions were needed.
authors.affiliation: Department of Pediatrics, Teikyo University School of Medicine, Ichihara Hospital.
authors.forename: H
authors.initials: H
authors.lastname: Meguro
mesh_terms: D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology; D004196:Disease Outbreaks; D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D016106:Methicillin Resistance; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D014041:Tokyo / Q000453:epidemiology