A neuropharmacological analysis of compensatory-restorative processes in organic deficit of the parafascicular complex of the thalamus.
It has been demonstrated in freely behaving cats, on the basis of a model of the biological precursors of concrete and abstract thinking, that, in the presence of a neurosurgical lesion of various divisions of the parafascicular complex of the thalamus, the restoration of disturbed functions by neuropharmacological agents through an effect on dopamine-, choline-, and GABAergic systems is possible. There is specialization in the neurochemical pathways of the lateral and medial regions of the complex, which opens the possibility of the topical correction of psychopathology of the thalamic level.
Mukhin
E I
EI
Institute of the Brain, Academy of Medical Sciences of the USSR, Moscow.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D001927:Brain Diseases / Q000473:pathology*; D002415:Cats; D003213:Conditioning, Psychological / Q000187:drug effects; D005260:Female; D008297:Male; D009434:Neural Pathways / Q000187:drug effects / Q000502:physiology; D011619:Psychotropic Drugs / Q000494:pharmacology; D013788:Thalamus / Q000187:drug effects / Q000473:pathology*
D011619:Psychotropic Drugs