Effect of intraperitoneally administered nucleoside-nucleotide on the recovery from methicillin-resistant Staphylococcus aureus strain 8985N infection in mice.
The effect of intraperitoneally administered nucleoside-nucleotide on the recovery from methicillin-resistant Staphylococcus aureus (MRSA) strain 8985N infection was studied in mice. Mice fed nucleic acid-free 20% casein diet were administered intraperitoneally with a nucleoside-nucleotide mixture or with saline (control group) daily for 30 days. On the tenth day on this treatment, mice were challenged with the bacteria. The survival rates were 25% and 72% for the control and nucleoside-nucleotide groups, respectively. The recovery of the survived mice from the infection was confirmed by the increment of body weight and the reduction of the bacteria in the organs. The results show the effectiveness of the intraperitoneal administration of the nucleoside-nucleotide mixture for the recovery from the MRSA strain 8985N infection in mice.
Adjei
A A
AA
School of Health Sciences and Research Center of Comprehensive Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
Takamine
F
F
Yokoyama
H
H
Chung
S Y
SY
Asato
L
L
Shinjo
S
S
Imamura
T
T
Yamamoto
S
S
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D015169:Colony Count, Microbial; D005260:Female; D007274:Injections, Intraperitoneal; D016106:Methicillin Resistance; D051379:Mice; D008807:Mice, Inbred BALB C; D009705:Nucleosides / Q000008:administration & dosage / Q000494:pharmacology*; D009711:Nucleotides / Q000008:administration & dosage / Q000494:pharmacology*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus; D015996:Survival Rate
D009705:Nucleosides; D009711:Nucleotides