[Clinical activity and serum immunoglobulin concentrations in patients with ankylosing spondylitis].
Several authors have suggested that immunoglobulin A plays a pathogenic role in ankylosing spondylitis. We have determined the levels of immunoglobulins in 30 patients, observing higher levels than in control patients (248 vs 176 mg/dl); p less than 0.01) and a relation between the increase of immunoglobulin A and the presence of clinical activity in the subgroup of patients B27-negative (163 vs 398 mg/dl, p less than 0.005), but not in B27-positive patients. We think that these e results support the hypothesis that ankylosing spondylitis is an heterogeneous disease, with different pathogenic mechanisms depending on the presence or absence of the serological marker HLA-B27.
Casals Sánchez
J L
JL
Servicio de Reumatología, Hospital Universitario de Granada.
González Calvin
J
J
García Sánchez
A
A
Abellán Pérez
M
M
Salvatierra Ríos
D
D
D004198:Disease Susceptibility; D015796:HLA-B27 Antigen / Q000032:analysis*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology*; D007070:Immunoglobulin A / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D013167:Spondylitis, Ankylosing / Q000097:blood / Q000145:classification / Q000235:genetics / Q000276:immunology*
D015796:HLA-B27 Antigen; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M
Estudio de la actividad clínica y de las concentraciones séricas de inmunoglobulinas en pacientes con espondilitis anquilosante.