title: Effect of ambroxol on rabbit eustachian tube surfactant.
abstract: The effect of ambroxol administration on phospholipid and phosphatidyl-choline contents of rabbit eustachian tube and lung washings and on [14C]-choline incorporation by rabbit eustachian tube and lung tissue has been studied. Despite minor differences, the drug exerts the same activating effect in both locations. The results add a further piece of evidence to the several similarities existing between the lung surfactant and the surface-active substances present on the eustachian tube.
authors.affiliation: Clinica Otorinolaringoiatrica, Università di Pavia, Italia.
authors.forename: E
authors.initials: E
authors.lastname: Mira
authors.forename: M
authors.initials: M
authors.lastname: Benazzo
authors.forename: M
authors.initials: M
authors.lastname: Manzoni
authors.forename: L
authors.initials: L
authors.lastname: Lligona
authors.forename: M
authors.initials: M
authors.lastname: Salmona
authors.forename: M T
authors.initials: MT
authors.lastname: Tacconi
mesh_terms: D000551:Ambroxol / Q000494:pharmacology*; D000818:Animals; D005064:Eustachian Tube / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000032:analysis; D010713:Phosphatidylcholines / Q000032:analysis* / Q000096:biosynthesis / Q000737:chemistry; D010743:Phospholipids / Q000032:analysis*; D011663:Pulmonary Surfactants / Q000737:chemistry / Q000187:drug effects*; D011817:Rabbits; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D010169:Palmitic Acids; D010713:Phosphatidylcholines; D010743:Phospholipids; D011663:Pulmonary Surfactants; D013501:Surface-Active Agents; D000551:Ambroxol; D019308:Palmitic Acid