title: Disposition of 8-methyl-8-azabicyclo[3,2,1]octan-3-yl 3,5-dichlorobenzoate, a potent 5-hydroxytryptamine antagonist, and two metabolites in dogs and monkeys.
abstract: The disposition of 8-methyl-8-azabicyclo[3,2,1]octan-3-yl 3,5-dichlorobenzoate (MDL 72,222; 1), a potent 5-hydroxytryptamine antagonist, and its N-demethylated and N-oxide metabolites was studied in dogs and monkeys. After single, intravenous doses of 1 at 5 mg/kg, the mean terminal half-lives of 1 in plasma were 2.6 h in the dog and 3.8 h in the monkey. The mean half-life of the N-demethylated metabolite in dogs (approximately 20 h) was very similar to that in monkeys. However, the mean half-life of the N-oxide metabolite in dogs (10.8 h) was different from that in monkeys (3.9 h). The steady-state volume of distribution of 1 was 16 L/kg in dogs and 8.9 L/kg in monkeys. Examination of the mean residence times revealed that 1, in both species, and the N-oxide metabolite, in dogs, distributed to the peripheral tissue, whereas the distribution of the N-demethylated metabolite in both species and the N-oxide metabolite in monkeys was limited mainly to the systemic circulation. Compound 1 was metabolized extensively in both species. In dogs, 0.7, 2.5 and 40.6% of the administered dose were excreted in 0-120-h urine samples as 1 and its N-demethylated and N-oxide metabolites, respectively. In monkeys, however, the corresponding percentages were 0.8, 0.7, and 1.8%. Most of the administered dose in monkeys was excreted in urine as 3,5-dichlorobenzoic acid and its glycine conjugate.
authors.affiliation: Merrell Dow Research Institute, Indianapolis, IN 46268.
authors.forename: H
authors.initials: H
authors.lastname: Cheng
authors.forename: D L
authors.initials: DL
authors.lastname: Larsen
authors.forename: J A
authors.initials: JA
authors.lastname: Ragner
authors.forename: G D
authors.initials: GD
authors.lastname: Sproles
authors.forename: W P
authors.initials: WP
authors.lastname: Gordon
mesh_terms: D000818:Animals; D004285:Dogs; D008252:Macaca fascicularis; D008297:Male; D008745:Methylation; D010084:Oxidation-Reduction; D012702:Serotonin Antagonists / Q000493:pharmacokinetics*; D014326:Tropanes / Q000378:metabolism / Q000493:pharmacokinetics*
chemical_list: D012702:Serotonin Antagonists; D014326:Tropanes; C042253:bemesetron