Inhibition by basic drugs of digoxin secretion into human bile.
Bile samples from previous interaction studies in man were re-analysed by a combined HPLC/radioimmunoassay method. Quinidine, quinine and verapamil but not probenecid or spironolactone were found to inhibit the biliary secretion of unchanged digoxin.
Hedman
A
A
Department of Clinical Pharmacology, Karolinska Institute, Huddinge University Hospital, Sweden.
D001646:Bile / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D004077:Digoxin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004347:Drug Interactions; D006801:Humans; D011339:Probenecid / Q000494:pharmacology; D011802:Quinidine / Q000494:pharmacology*; D011803:Quinine / Q000494:pharmacology*; D011863:Radioimmunoassay; D013148:Spironolactone / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology*
D013148:Spironolactone; D004077:Digoxin; D011803:Quinine; D014700:Verapamil; D011802:Quinidine; D011339:Probenecid