Effect of benomyl toxicity on some liver constituents of albino rats.
Weanling albino rats were fed 0-600 mg/kg body weight methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate (benomyl) for 7 d, and effects on protein, glycogen, and vitamin A constituents were recorded. Doses fed in rat chow were 0, 40, 80, 125, 165, 200, 240, 280, 320, 360, 400, 440, 480, 520, 560, and 600 mg/kg body weight. There was a dose-dependent decrease in the concentration of liver constituents, of which glycogen decreased the most. Histopathological findings included cellular swelling and edema of the liver, kidney, and spleen.
Igbedioh
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College of Food Technology, University of Agriculture, Makurdi, Nigeria.
Akinyele
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D000818:Animals; D001542:Benomyl / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D008107:Liver Diseases / Q000473:pathology*; D008112:Liver Glycogen / Q000032:analysis / Q000187:drug effects; D008297:Male; D009336:Necrosis; D009929:Organ Size / Q000187:drug effects; D011506:Proteins / Q000032:analysis / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014801:Vitamin A / Q000032:analysis
D008112:Liver Glycogen; D011506:Proteins; D014801:Vitamin A; D001542:Benomyl