title: Reagents for the site-specific cleavage of megabase DNA.
abstract: The physical mapping of chromosomes will be facilitated by methods of breaking large DNA into manageable fragments, or cutting uniquely at genetic markers of interest. Key issues in the design of sequence-specific DNA cleaving reagents are the specificity of binding, the number of different sequences that can be targeted and the cleavage yield.
authors.affiliation: Division of Chemistry, California Institute of Technology, Pasadena 91125.
authors.forename: P B
authors.initials: PB
authors.lastname: Dervan
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D015183:Restriction Mapping
chemical_list: D004247:DNA