title: Perspectives on combination chemotherapy with concomitant radiotherapy for poor-prognosis head and neck cancer.
abstract: Concomitant chemoradiotherapy has resulted in small increases in disease-free or overall survival for patients with advanced head and neck cancer when single-agent chemotherapy is used. To increase the efficacy of this approach, combination chemotherapy also has been explored. In this setting, acute toxicities are frequently increased, necessitating interruption or protraction of radiotherapy. Despite this fact, pilot trials using 5-fluorouracil-based chemotherapy have indicated high response and encouraging survival rates. Some of these trials will be reviewed, with a focus on studies with 5-fluorouracil, hydroxyurea, and cisplatin conducted at the University of Chicago.
authors.affiliation: Department of Medicine, University of Chicago, IL.
authors.forename: E E
authors.initials: EE
authors.lastname: Vokes
authors.forename: D J
authors.initials: DJ
authors.lastname: Haraf
authors.forename: R R
authors.initials: RR
authors.lastname: Weichselbaum
authors.forename: J M
authors.initials: JM
authors.lastname: McEvilly
authors.forename: H G
authors.initials: HG
authors.lastname: Sutton
authors.forename: W R
authors.initials: WR
authors.lastname: Panje
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011878:Radiotherapy / Q000009:adverse effects