title: A comparative study of formaldehyde detection using chromotropic acid, acetylacetone and HPLC in cosmetics and household cleaning products.
abstract: Chromotropic acid and acetylacetone methods for qualitative determination of formaldehyde were tested in parallel on 48 commercial samples, with high-performance liquid chromotography (HPLC) implemented for quantitative measure. In addition, interference with the detection of formaldehyde was investigated by analyzing 12 other aldehydes and ketones, 7 essential oils and 3 polysorbates. Throughout this comparative study, the disadvantages of the chromotropic acid method, of which 2 variants were used, were delineated and we found that the acetylacetone test proved to be a more efficient screening method for formaldehyde detection in a clinical laboratory.
authors.affiliation: Department of Dermatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Gryllaki-Berger
authors.forename: C
authors.initials: C
authors.lastname: Mugny
authors.forename: D
authors.initials: D
authors.lastname: Perrenoud
authors.forename: A
authors.initials: A
authors.lastname: Pannatier
authors.forename: E
authors.initials: E
authors.lastname: Frenk
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004396:Coloring Agents; D003358:Cosmetics / Q000737:chemistry*; D005189:False Positive Reactions; D005557:Formaldehyde / Q000032:analysis*; D006795:Household Products / Q000032:analysis*; D006801:Humans; D007202:Indicators and Reagents; D009282:Naphthalenesulfonates; D010422:Pentanones; D012680:Sensitivity and Specificity
chemical_list: D004396:Coloring Agents; D003358:Cosmetics; D007202:Indicators and Reagents; D009282:Naphthalenesulfonates; D010422:Pentanones; D005557:Formaldehyde; C008790:acetylacetone; C020996:chromotropic acid