[State of the renin-angiotensin system in children with different clinical variants of congenital adrenal cortex hyperplasia caused by 21-hydroxylase deficiency].
A study was made of plasma renin activity (PRA) and serum aldosterone (A) in 52 children with congenital hyperplasia of the adrenal cortex due to 21-hydroxylase deficiency. There were 40 girls and 12 boys aged 1.5 months to 14 years. Of these, 35 had the salt-losing form (group 1), 12 were with a simple virile form (group 2), and 2 with the typical disease form (group 3). By the moment of the first examination the majority of the group 1 patients had received glucocorticoids (GC) combined with mineralocorticoids (MC), group 2 had been given GC alone, and the group 3 children had been untreated. Initially PRA in both the first and second groups was higher than in the controls. However, in group 2 that difference was insignificant. The concentration of A in group 2 noticeably exceeded that in the controls and group 1. In group 3, PRA and A did not differ from normal. After the treatment was potentiated by MC (including MC administration to the group 2 patients) there was a decline of PRA and of the A level. The changes in PRA and A did not often manifest clinically and were not associated with electrolyte disturbances. In the authors' opinion, to choose adequate doses of MC, it is necessary to examine PRA and blood A level.
Kasatkina
E P
EP
Tiul'pakov
A N
AN
Goriaĭnova
I I
II
D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D000450:Aldosterone / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003348:Cortisone / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System
D005938:Glucocorticoids; D000450:Aldosterone; D011239:Prednisolone; D012083:Renin; D003348:Cortisone
Sostoianie renin-angiotenzinovoĭ sistemy u deteĭ s razlichnymi klinicheskimi variantami vrozhdennoĭ giperplazii kory nadpochechnikov, obuslovennoĭ defitsitom 21-gidroksilazy.