[The role of the endothelium in the vascular effects of vintoperol].
The effects of vintoperol have been studied in the experiments on the vascular bed of femoral artery of 15 mongrel dogs under chlorazol-urethane narcosis and on isolated vascular preparations of rats. It is shown that ++de-endothelization of vascular bed using saponin and mechanical removal of endothelial stripes decreased the vasodilatation reaction and relaxation of stripes by 50-60% of the initial values. While infusing ventoperol (0.3 mg.kg-1 min-1) to ++de-endothelized vascular bed, the blood flow increased by 18 +/- 5% as against 47 +/- 3.9% of the initial value under intact endothelium. Blockade of guanylate cyclase by methylene blue decreased blood flow under vintoperol action to 24 +/- 3.5%. The similar results are obtained in the experiments in vitro. After ++de-endothelization of pulmonary artery++ the amplitude of relaxation of preactivated smooth muscles decreased vs. initial tone (21 +/- 3.7% vs. 56% +/- 5.3%). Inhibition of relaxation reaction of vascular stripe under vintoperol effect is also observed after treatment with gossypol, or methylene blue. Thus, endothelium is involved in the realization of vasodilating effect of vintoperol, its action being mediated by endothelium--derived relaxing factor.
Sahach
V F
VF
Tkachenko
M M
MM
Bazyliuk
O V
OV
D000818:Animals; D004285:Dogs; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D005263:Femoral Artery / Q000187:drug effects / Q000502:physiology*; D006614:Hindlimb / Q000098:blood supply*; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology*; D008955:Models, Cardiovascular; D009126:Muscle Relaxation / Q000187:drug effects / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D009569:Nitric Oxide / Q000502:physiology*; D011651:Pulmonary Artery / Q000187:drug effects / Q000502:physiology*; D011807:Quinolizines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D014665:Vasodilator Agents / Q000494:pharmacology*
D007211:Indoles; D011807:Quinolizines; D014665:Vasodilator Agents; D009569:Nitric Oxide; C066359:vintoperol
Rol' endoteliiu u sudynnykh efektakh vintoperolu.