title: Disseminated Langerhans cell histiocytosis in identical twins unresponsive to recombinant human alpha-interferon and total body irradiation.
abstract: Monozygotic twin boys presented at 1 year of age with seborrheic skin rash, otorrhea, and hepatosplenomegaly. Skin biopsy confirmed Langerhans cell histiocytosis. Treatment with conventional antineoplastic drugs and with calf thymus extract was ineffective. The disease remained refractory to recombinant human alpha-interferon and to low-dose total body irradiation, and the children died between 3 and 3 1/2 years of age.
authors.affiliation: Children's Hospital at Chedoke-McMaster, Hamilton, Ontario, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Halton
authors.forename: A
authors.initials: A
authors.lastname: Whitton
authors.forename: J
authors.initials: J
authors.lastname: Wiernikowski
authors.forename: R D
authors.initials: RD
authors.lastname: Barr
mesh_terms: D003131:Combined Modality Therapy; D004200:Diseases in Twins / Q000628:therapy*; D006646:Histiocytosis, Langerhans-Cell / Q000628:therapy*; D006801:Humans; D007223:Infant; D007370:Interferon Type I / Q000627:therapeutic use*; D008297:Male; D011994:Recombinant Proteins; D014430:Twins, Monozygotic; D014916:Whole-Body Irradiation
chemical_list: D007370:Interferon Type I; D011994:Recombinant Proteins