Pittsburgh Epidemiology of Diabetes Complications Study. Measuring diabetic neuropathy follow-up study results.
OBJECTIVE
This project evaluated the utility of quantitative sensory techniques in predicting the development of neuropathy for subjects participating in a prospective study.


METHODS
Distal symmetric polyneuropathy was evaluated in 77 insulin-dependent diabetes mellitus individuals via quantitative sensory testing, nerve conduction studies, and clinical examination.


RESULTS
Although the specificity and positive predictive value were low for the quantitative sensory techniques as predictors of neuropathy diagnosed on clinical exam approximately 2 yr later, the sensitivity for vibratory thresholds was high (100%). Variability over the 2-yr interval was shown on follow-up testing for each of the objective assessment modalities and it was not explained by differences for potential risk factors measured at baseline.


CONCLUSIONS
Despite a cross-sectional relationship between the assessment modalities and clinically overt neuropathy at baseline, these follow-up data suggest that the potential for the objective modalities as predictors of clinically diagnosed neuropathy may be limited.
Maser
R E
RE
School of Life and Health Sciences, University of Delaware, Newark 19716.
Becker
D J
DJ
Drash
A L
AL
Ellis
D
D
Kuller
L H
LH
Greene
D A
DA
Orchard
T J
TJ
D000328:Adult; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000503:physiopathology; D003929:Diabetic Neuropathies / Q000453:epidemiology* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009460:Neurologic Examination; D010414:Pennsylvania / Q000453:epidemiology; D011379:Prognosis; D012684:Sensory Thresholds; D013696:Temperature; D014505:Urban Population; D014732:Vibration