title: McArdle's disease and gout.
abstract: We report the first case of McArdle's disease (muscle phosphorylase deficiency) and tophaceous gout. To examine the contribution of adenine nucleotide degradation to the disturbance of uric acid metabolism, we labeled the adenine nucleotide pool with [8-14C]adenine, and measured plasma and urine purines following vigorous exercise tests. Plasma and urinary hypoxanthine and xanthine concentrations and the specific radioactivity of urinary purines increased markedly, but plasma urate levels and uric acid excretion were not substantially modified. We suggest that, in this patient, the association of McArcle's disease with gout is coincidental.
authors.affiliation: Department of Internal Medicine, La Paz University Hospital, Madrid, Spain.
authors.forename: J G
authors.initials: JG
authors.lastname: Puig
authors.forename: E
authors.initials: E
authors.lastname: de Miguel
authors.forename: F A
authors.initials: FA
authors.lastname: Mateos
authors.forename: E
authors.initials: E
authors.lastname: Miranda
authors.forename: N M
authors.initials: NM
authors.lastname: Romera
authors.forename: A
authors.initials: A
authors.lastname: Espinosa
authors.forename: J
authors.initials: J
authors.lastname: Gijón
mesh_terms: D000227:Adenine Nucleotides / Q000652:urine; D015210:Arthritis, Gouty / Q000097:blood / Q000209:etiology* / Q000652:urine; D005080:Exercise Test; D006012:Glycogen Storage Disease Type V / Q000097:blood / Q000150:complications* / Q000652:urine; D006801:Humans; D008297:Male; D008875:Middle Aged; D011687:Purines / Q000097:blood / Q000652:urine; D014527:Uric Acid / Q000652:urine
chemical_list: D000227:Adenine Nucleotides; D011687:Purines; D014527:Uric Acid