title: Comparisons of the development of auditory brainstem response latencies between cats and humans.
abstract: Developmental changes in the peak latencies of auditory brainstem responses (ABR) recorded from humans and kittens were compared to test the hypothesis that developmental time courses among mammals are the same when appropriately normalized. Response latencies were computed as the difference from adult latency and conceptional ages were represented as percentages relative to the age that ABR wave latencies achieved a criterion value within 0.2 ms of asymptotic latency (i.e., adulthood). An underlying assumption of this exercise is that far-field response latency is an appropriate index of overall 'auditory development'. Results of this analysis suggest that developmental changes in latency of responses arising within the auditory periphery are similar between humans and cats, when appropriately normalized, and that more central changes show less correspondence. Consequently, absolute time course differences for specific developmental parameters must be considered and caution should be exercised when extrapolating results acquired from one species to the other.
authors.affiliation: Boys Town National Research Hospital, Omaha, Nebraska 68132.
authors.forename: E J
authors.initials: EJ
authors.lastname: Walsh
authors.forename: M
authors.initials: M
authors.lastname: Gorga
authors.forename: J
authors.initials: J
authors.lastname: McGee
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D000831:Animals, Newborn; D001933:Brain Stem / Q000254:growth & development / Q000502:physiology; D002415:Cats; D002675:Child, Preschool; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D013045:Species Specificity