title: Cerebral vascular changes associated with hemorrhagic stroke in hypertension.
abstract: There are a number of alterations that protect the cerebrovasculature from hemorrhagic stroke development during hypertension. The upper limit of cerebral blood flow autoregulation is shifted to higher blood pressure levels; this allows a constant blood flow to be maintained during hypertension. Studies we have performed have indicated that the middle cerebral arteries (MCA) of Wistar-Kyoto stroke-prone spontaneously hypertensive rats (spSHR) lose their ability to constrict in response to elevations in transmural pressure. The decline in such function precedes stroke development and totally disappears at an age where there is a 100% mortality from stroke. Prior to stroke development, spSHR also develop uremic conditions and signs of renal failure. The induction of uremia in stroke-resistant SHR (srSHR) via nephrectomy induces these animals to develop stroke. Like prestroke spSHR, prestroke uremic srSHR also have MCA with attenuated pressure-dependent myogenic function. It is hypothesized that the inability to increase vascular resistance in response to elevations in pressure might promote overperfusion of the more distal vasculature leading to cerebral hemorrhage formation. Since uremia promotes bleeding tendencies, such alterations along with the loss of cerebrovascular myogenic function could initiate or aggravate hemorrhage formation.
authors.affiliation: Department of Anaesthesia, McMaster University, Hamilton, Ont., Canada.
authors.forename: J S
authors.initials: JS
authors.lastname: Smeda
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D002536:Cerebral Arteries / Q000503:physiopathology; D002543:Cerebral Hemorrhage / Q000209:etiology / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002561:Cerebrovascular Disorders / Q000209:etiology / Q000503:physiopathology*; D004032:Diet; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D008297:Male; D009129:Muscle Tonus / Q000502:physiology; D009392:Nephrectomy; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D014511:Uremia / Q000503:physiopathology; D014700:Verapamil / Q000494:pharmacology
chemical_list: D014700:Verapamil