L-dopa binding sites in rodent melanoma cells.
Rapid, saturable, specific and stereoselective binding of L-dopa to crude membranes and purified nuclei from rodent amelanotic melanoma cells is reported. Cross-linking of [3H]dopa to melanoma cell surface emphasized proteins of approx. 55, 30, 25 and less than 20 kDa. It is suggested that these binding sites may regulate melanocyte activity.
Slominski
A
A
Pruski
D
D
D000818:Animals; D001665:Binding Sites; D002352:Carrier Proteins / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism*; D006224:Cricetinae; D007980:Levodopa / Q000378:metabolism*; D008545:Melanoma / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D014407:Tumor Cells, Cultured
D002352:Carrier Proteins; D008565:Membrane Proteins; D007980:Levodopa