[Antimicrobial and membranolytic activities of anti-burn drug fenozan].
Fenozan, an anti-burn preparation, was shown to have antimicrobial activity against freshly isolated clinical strains of Staphylococcus aureus and Streptococcus faecalis, as well as against collection strains of the other gram-positive bacteria. The antimicrobial action of the preparation was possibly due to impairment of permeability of the cytoplasmic membranes in the sensitive bacterial cells and their liberation of intracellular low molecular weight compounds to the environment. The membranolytic and minimum inhibitory concentrations of fenozan with respect to the sensitive bacterial cells were one order of magnitude lower than the concentration stabilizing the membranes of animal cells in the treatment of burns. Combination of the antioxidant and antimicrobial properties in fenozan was likely to provide its satisfactory therapeutic effect in the treatment of burn wounds.
Petrykina
Z M
ZM
Polin
A N
AN
Plekhanova
L G
LG
Ershov
V V
VV
Petrov
I V
IV
D001407:Bacillus / Q000187:drug effects* / Q000648:ultrastructure; D002056:Burns / Q000188:drug therapy / Q000382:microbiology*; D002463:Cell Membrane Permeability / Q000187:drug effects; D013293:Enterococcus faecalis / Q000187:drug effects* / Q000648:ultrastructure; D004926:Escherichia coli / Q000187:drug effects* / Q000648:ultrastructure; D006801:Humans; D066298:In Vitro Techniques; D008837:Micrococcus / Q000187:drug effects* / Q000648:ultrastructure; D010666:Phenylpropionates / Q000494:pharmacology* / Q000627:therapeutic use; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000648:ultrastructure; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000648:ultrastructure
D010666:Phenylpropionates; C047854:fenozan
Antimikrobnaia i membranoliticheskaia aktivnost' protivoozhogovogo preparata fenozana.