Cytokines and growth factors in the pathogenesis of AIDS-associated Kaposi's sarcoma.
In the past, the study of KS pathogenesis has been hampered by the lack of in vitro and in vivo experimental systems. Recently, the establishment of long-term cultures of KS spindle cells and the development of animal models have allowed a variety of studies on the pathobiology of the disease. The results from these studies, reviewed herein, indicate that KS is a cytokine-mediated disease and that inflammatory and angiogenic cytokines and the HIV-1 Tat protein cooperate in its induction and progression in HIV-1-infected individuals.
Ensoli
B
B
Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
Barillari
G
G
Gallo
R C
RC
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000818:Animals; D016207:Cytokines / Q000276:immunology*; D004195:Disease Models, Animal; D015756:Genes, tat / Q000276:immunology; D006133:Growth Substances / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D012514:Sarcoma, Kaposi / Q000276:immunology*; D014407:Tumor Cells, Cultured
D016207:Cytokines; D006133:Growth Substances