title: New cyclosporin A analogue: synthesis and immunosuppressive activity.
abstract: A synthetic analogue of cyclosporine A, in which an unusual amino acid (4R)-N-methyl-4-butenyl-4-methyl-L-threonine (MeBmt) is replaced with L-threonine (Thr), was synthesized by the solid phase method. Its activity in the humoral response to sheep red blood cells in vitro and in vivo in mice was practically the same as that of cyclosporine A used as a standard, whereas the analogue studied exerted a significantly stronger effect in the delayed type hypersensitivity to sheep red blood cells in mice.
authors.affiliation: Institute of Chemistry, University of Gdańsk, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Rózycki
authors.forename: K
authors.initials: K
authors.lastname: Rolka
authors.forename: Z
authors.initials: Z
authors.lastname: Wièczorek
authors.forename: M
authors.initials: M
authors.lastname: Zimecki
authors.forename: G
authors.initials: G
authors.lastname: Kupryszewski
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003524:Cyclosporins / Q000138:chemical synthesis* / Q000737:chemistry / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007109:Immunity / Q000187:drug effects*; D007111:Immunity, Cellular / Q000187:drug effects; D007075:Immunoglobulin M / Q000096:biosynthesis; D007274:Injections, Intraperitoneal; D051379:Mice; D008808:Mice, Inbred CBA; D008969:Molecular Sequence Data; D012756:Sheep; D013154:Spleen / Q000276:immunology / Q000378:metabolism; D014611:Vaccination
chemical_list: D003524:Cyclosporins; D007075:Immunoglobulin M