Energy expenditure and gas exchange measurements in postoperative patients: thermodilution versus indirect calorimetry.
OBJECTIVE
To compare a method of measuring energy expenditure and gas exchange using the Fick principle with the standard indirect calorimetry technique.


METHODS
Prospective study of a consecutive sample of postoperative patients. Oxygen consumption (VO2), CO2 production (VCO2), respiratory quotient, and energy expenditure were derived from measurements of variables, including oxygen content and cardiac output. Energy expenditure and gas exchange were measured simultaneously by continuous indirect calorimetry over a 60-min period.


METHODS
Surgical ICU in a university hospital.


METHODS
Twenty-six consecutive patients (45 to 80 yrs) who underwent sustained surgical trauma. Excluded from the study entry were patients with time-related fluctuations of hemodynamic variables, poor cooperation, patients who required supplemental oxygen, or mechanical ventilation.


METHODS
None.


RESULTS
While the measurements of VO2 and VCO2 by calorimetry and thermodilution were significantly correlated with one another (for VO2, r2 = .93, p less than .001; for VCO2, r2 = .26, p less than .01), VO2 and VCO2 values by indirect calorimetry were consistently greater than VO2 and VCO2 values by the Fick method (p less than .01). The respiratory quotient calorimetric measurements ranged between 0.69 and 0.99, whereas the corresponding thermodilution measurements spread to impossible values, from 0.24 to 1.30 (0.821 +/- 0.07 vs. 0.740 +/- 0.24, p less than .05). There was an insignificant relationship (r2 = .06, p = .21) between the values of respiratory quotient by the two methods. A strong, positive correlation between energy expenditure measured by indirect calorimetry and energy expenditure measured by the Fick method was observed (r2 = .92, p less than .001). The limit of agreement between the two methods was -0.24 +/- 73 kcal/day/m2 (-1.00 +/- 305 kJ/day/m2).


CONCLUSIONS
In postoperative patients, while VO2 and energy expenditure measurements by thermodilution are easy to perform and accurate for clinical purposes, VCO2, and respiratory quotient measurements are too imprecise and inaccurate to serve any useful function. Therefore, in those clinical situations in which an evaluation of respiratory quotient and substrate utilization may be useful for purposes of metabolic care of the surgical patient, precise measurements of gas exchange with indirect calorimetry are mandatory.
Brandi
L S
LS
Department of Anesthesiology and Intensive Care, University of Pisa, Italy.
Grana
M
M
Mazzanti
T
T
Giunta
F
F
Natali
A
A
Ferrannini
E
E
D002153:Calorimetry, Indirect / Q000379:methods / Q000706:statistics & numerical data; D016638:Critical Illness; D004734:Energy Metabolism; D005069:Evaluation Studies as Topic; D006801:Humans; D008991:Monitoring, Physiologic / Q000379:methods / Q000706:statistics & numerical data; D011184:Postoperative Period; D011446:Prospective Studies; D011659:Pulmonary Gas Exchange; D013815:Thermodilution / Q000379:methods / Q000706:statistics & numerical data; D013997:Time Factors