A-71623, a selective CCK-A receptor agonist, suppresses food intake in the mouse, dog, and monkey.
The anorectic actions of cholecystokinin (CCK)-8 and of a selective CCK-A agonist, A-71623, were examined in CD1 mice, beagle dogs, and cynomolgus monkeys. A-71623 suppressed intakes in all species tested, and the effects were blocked by a selective CCK-A antagonist, A-70104. In the dog only, CCK-8 was more potent on a molar basis compared to A-71623, although the effects of both CCK agonists were more short-lived in the dog compared to the other species tested. Our results support other evidence suggesting that the anorectic actions of exogenous application of CCK-8 in these species are mediated via stimulation of the CCK-A receptor subtype.
Asin
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Abbott Laboratories, Division of Neurological Sciences, Abbott Park, IL 60064.
Bednarz
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Nikkel
A L
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Gore
P A
PA
Nadzan
A M
AM
D000818:Animals; D002766:Cholecystokinin / Q000494:pharmacology; D003864:Depression, Chemical; D004285:Dogs; D004435:Eating / Q000187:drug effects*; D008252:Macaca fascicularis; D008297:Male; D051379:Mice; D011804:Quinolines / Q000494:pharmacology; D011949:Receptors, Cholecystokinin / Q000187:drug effects / Q000502:physiology*; D013045:Species Specificity; D013758:Tetragastrin / Q000031:analogs & derivatives* / Q000494:pharmacology
D011804:Quinolines; D011949:Receptors, Cholecystokinin; D013758:Tetragastrin; C063047:A 65186; C066278:A 71623; D002766:Cholecystokinin