title: Limited genetic diversity in polynesians reflected in the highly polymorphic 3'HVR alpha-globin gene marker.
abstract: Polynesians from five distinct island groups were studied with DNA probe alpha 3'HVR, a highly polymorphic VNTR (variable number of tandem repeats) minisatellite region associated with the alpha-globin gene cluster. Results showed a paucity of genetic heterozygosity together with clustering of alpha 3'HVR alleles with alpha-globin DNA haplotypes and alpha-globin gene rearrangements. This restricted diversity is consistent with population bottlenecks in the colonization of Polynesia.
authors.affiliation: Department of Molecular Genetics, Royal Prince Alfred Hospital, Camperdown, N.S.W., Australia.
authors.forename: M S
authors.initials: MS
authors.lastname: Hertzberg
authors.forename: K N
authors.initials: KN
authors.lastname: Mickleson
authors.forename: R J
authors.initials: RJ
authors.lastname: Trent
mesh_terms: D000483:Alleles; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics*; D005914:Globins / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D011114:Polynesia / Q000453:epidemiology; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics
chemical_list: D005819:Genetic Markers; D005914:Globins; D004247:DNA