title: [Complete hormonal blockade vs. monotherapy in the management of metastasizing prostatic cancer].
abstract: Evaluation of results obtained in 70 hormone-treated patients with disseminated prostate cancer. Thirty-six of them were treated via orchiectomy and 34 received also flutamide. Initial objective response rates were 47% in the monotherapy group versus 58% for those undergoing complete blockade. Decrease of PSA and PAP was also higher in the group given flutamide. Nonetheless, no significant changes were observed with regard to biological and clinical progression or patients survival.
authors.affiliation: Servicio de Urología, Ciudad Sanitaria Vall d'Hebron, Barcelona, España.
authors.forename: J
authors.initials: J
authors.lastname: Morote Robles
authors.forename: J
authors.initials: J
authors.lastname: Vila Barja
authors.forename: M A
authors.initials: MA
authors.lastname: López Pacios
authors.forename: J A
authors.initials: JA
authors.lastname: de Torres Mateos
authors.forename: A
authors.initials: A
authors.lastname: Soler Roselló
mesh_terms: D004341:Drug Evaluation; D005485:Flutamide / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis / Q000517:prevention & control; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
chemical_list: D005485:Flutamide
vernacular_title: Bloqueo hormonal completo versus monoterapia en el tratamiento del cáncer de próstata metastásico.