OmpF channel permeability of quinolones and their comparison with beta-lactams.
The diffusion rates of nalidixic acid, ofloxacin and ofloxacin's two optically active isomers through OmpF channels were measured in proteoliposomes and compared with the rates of beta-lactams. The four quinolones showed high diffusion rates, exceeding that of cephaloridine and being comparable to imipenem. There was no significant difference in diffusion rate between nalidixic acid and ofloxacin, or between the two optically active isomers. The diffusion rates of enoxacin and norfloxacin were also estimated to be higher than many beta-lactams.
Sawai
T
T
Division of Microbial Chemistry, Faculty of Pharmaceutical Sciences, Chiba University, Japan.
Yamaguchi
A
A
Saiki
A
A
Hoshino
K
K
D000900:Anti-Bacterial Agents / Q000378:metabolism*; D000890:Anti-Infective Agents / Q000378:metabolism*; D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism*; D002463:Cell Membrane Permeability; D002511:Cephalosporins / Q000378:metabolism; D004058:Diffusion; D015365:Enoxacin / Q000378:metabolism; D004926:Escherichia coli / Q000378:metabolism*; D008081:Liposomes / Q000378:metabolism; D009268:Nalidixic Acid / Q000378:metabolism; D009643:Norfloxacin / Q000378:metabolism; D015242:Ofloxacin / Q000378:metabolism; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001425:Bacterial Outer Membrane Proteins; D002511:Cephalosporins; D008081:Liposomes; D015365:Enoxacin; D009268:Nalidixic Acid; D015242:Ofloxacin; D009643:Norfloxacin