title: In vivo clearance and elimination of nine marker substances during hemofiltration with different membranes.
abstract: The handling of low, middle and high molecular weight markers was examined in seven stable dialysis patients during hemofiltration with different membranes. Four membranes were examined in a randomized, crossover order (polysulfone, polyamide, AN69 polyacrylonitrile, Asahi polyacrylonitrile) by measuring plasma and dialysate concentrations of phosphate, creatinine, vitamin B12, beta 2-microglobulin, furanic acid, hippuric acid, retinol-binding protein, alpha-1-antitrypsin, and albumin. Sieving coefficients and plasma clearances of beta 2-microglobulin or retinol-binding protein were markedly or slightly lower during hemofiltration with the Asahi polyacrylonitrile membrane than with the other membranes (highest removal with polysulfone/AN69 polyacrylonitrile membranes). No differences of obvious clinical relevance could be seen between the four membranes. A high beta 2-microglobulin removal rate might be important to prevent dialysis-associated amyloidosis.
authors.affiliation: III Department of Medicine, University of Tübingen, Germany.
authors.forename: B K
authors.initials: BK
authors.lastname: Krämer
authors.forename: A
authors.initials: A
authors.lastname: Pickert
authors.forename: C
authors.initials: C
authors.lastname: Hohmann
authors.forename: H M
authors.initials: HM
authors.lastname: Liebich
authors.forename: G A
authors.initials: GA
authors.lastname: Müller
authors.forename: M
authors.initials: M
authors.lastname: Hablitzel
authors.forename: T
authors.initials: T
authors.lastname: Risler
mesh_terms: D000368:Aged; D003404:Creatinine / Q000032:analysis / Q000097:blood; D015314:Dialysis Solutions / Q000737:chemistry; D006440:Hemofiltration; D006626:Hippurates / Q000032:analysis / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008567:Membranes, Artificial; D008875:Middle Aged; D008970:Molecular Weight; D010710:Phosphates / Q000032:analysis / Q000097:blood; D011897:Random Allocation; D006435:Renal Dialysis; D012177:Retinol-Binding Proteins / Q000032:analysis; D054839:Retinol-Binding Proteins, Plasma; D012709:Serum Albumin / Q000032:analysis; D014805:Vitamin B 12 / Q000032:analysis / Q000097:blood; D001613:beta 2-Microglobulin / Q000032:analysis
chemical_list: D015314:Dialysis Solutions; D006626:Hippurates; D008567:Membranes, Artificial; D010710:Phosphates; D012177:Retinol-Binding Proteins; D054839:Retinol-Binding Proteins, Plasma; D012709:Serum Albumin; D001613:beta 2-Microglobulin; D003404:Creatinine; D014805:Vitamin B 12; C030514:hippuric acid