title: Oral administration of calcium chloride-containing products: testing for deleterious side-effects.
abstract: Two products that contain CaCl2 and that are intended for oral administration were tested for safety aspects. One product contained CaCl2 as a gel, the other contained CaCl2 in an oil emulsion. Oral administration of the CaCl2-containing products caused minor to severe damage to the mucosa of the forestomach and abomasum. The gel solution especially proved to be highly caustic, while the oil emulsion appeared to be relatively safe.
authors.affiliation: Department of Large Animal Medicine and Nutrition, Faculty of Veterinary Medicine, Utrecht, The Netherlands.
authors.forename: G H
authors.initials: GH
authors.lastname: Wentink
authors.forename: T S
authors.initials: TS
authors.lastname: van den Ingh
mesh_terms: D000018:Abomasum / Q000187:drug effects; D000284:Administration, Oral; D000818:Animals; D002122:Calcium Chloride / Q000008:administration & dosage / Q000009:adverse effects*; D002417:Cattle; D002418:Cattle Diseases / Q000139:chemically induced*; D004655:Emulsions; D004947:Esophagus / Q000187:drug effects*; D005260:Female; D005782:Gels; D009061:Mouth Mucosa / Q000187:drug effects*; D009851:Omasum / Q000187:drug effects; D011897:Random Allocation; D012159:Reticulum / Q000187:drug effects; D013279:Stomach, Ruminant / Q000187:drug effects*
chemical_list: D004655:Emulsions; D005782:Gels; D002122:Calcium Chloride