Unusual oral presentation of non-Hodgkin's lymphoma in association with HIV infection.
In 4.4% of human immunodeficiency virus-associated non-Hodgkin's lymphoma the presenting lesion is seen in the mouth. Often the lesion may clinically resemble a less sinister process, and a definitive diagnosis of lymphoma may be delayed. We describe three unusual cases of non-Hodgkin's lymphoma, appearing intraorally in association with other oral lesions, in HIV-positive homosexual men. The three patients reported here were all diagnosed as having diffuse, large-cell malignant non-Hodgkin's lymphoma. We performed Epstein-Barr virus DNA in-situ hybridization on our cases and Epstein-Barr virus DNA sequences were not seen. We review the pertinent literature and stress the importance of including non-Hodgkin's lymphoma in the differential diagnosis of oral lesions in patients at risk of HIV infection.
Dodd
C L
CL
Department of Stomatology, University of California, San Francisco.
Greenspan
D
D
Schiødt
M
M
Daniels
T E
TE
Beckstead
J H
JH
MacPhail
L A
LA
Miyasaki
S
S
Greenspan
J S
JS
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000209:etiology*