Comparison of effects of pyronaridine, amodiaquine, mefloquine and qinghaosu on rodent malaria.
Blood schizontocidal effect of antimalarials were compared by 4-day suppressive test with an extended observation period of 31 days. On a drug-sensitive Plasmodium berghei ANKA strain, pyronaridine (PND) exhibited the best effect, followed by amodiaquine (ADQ), mefloquine (MFQ), and qinghaosu (QHS). On a moderately chloroquine-resistant P. berghei NS line, the order of effects was the same, PND greater than ADQ greater than MFQ greater than QHS. On a highly pyronaridine-resistant P. berghei RP line, ADQ, MFQ and QHS showed cross resistance with PND.
Shao
B R
BR
Institute of Parasitic Disease, Chinese Academy of Preventive Medicine, WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai.
Ye
X Y
XY
Chu
Y H
YH
D000655:Amodiaquine / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000627:therapeutic use*; D037621:Artemisinins; D004334:Drug Administration Schedule; D004353:Drug Evaluation, Preclinical; D004351:Drug Resistance; D005260:Female; D008288:Malaria / Q000188:drug therapy* / Q000401:mortality / Q000469:parasitology; D008297:Male; D015767:Mefloquine / Q000008:administration & dosage / Q000627:therapeutic use*; D051379:Mice; D009287:Naphthyridines / Q000008:administration & dosage / Q000627:therapeutic use*; D010962:Plasmodium berghei; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000627:therapeutic use*
D000962:Antimalarials; D037621:Artemisinins; D009287:Naphthyridines; D012717:Sesquiterpenes; D000655:Amodiaquine; C031327:artemisinin; C027871:pyronaridine; D015767:Mefloquine