Prediction of structural and functional features of protein and nucleic acid sequences by artificial neural networks.
The applications of artificial neural networks to the prediction of structural and functional features of protein and nucleic acid sequences are reviewed. A brief introduction to neural networks is given, including a discussion of learning algorithms and sequence encoding. The protein applications mostly involve the prediction of secondary and tertiary structure from sequence. The problems in nucleic acid analysis tackled by neural networks are the prediction of translation initiation sites in Escherichia coli, the recognition of splice junctions in human mRNA, and the prediction of promoter sites in E. coli. The performance of the approach is compared with other current statistical methods.
Hirst
J D
JD
Biomolecular Modelling Laboratory, Imperial Cancer Research Fund, London, U.K.
Sternberg
M J
MJ
D000465:Algorithms; D000595:Amino Acid Sequence; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D016571:Neural Networks, Computer; D009690:Nucleic Acid Conformation; D009696:Nucleic Acids / Q000737:chemistry* / Q000378:metabolism; D011401:Promoter Regions, Genetic; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D012333:RNA, Messenger / Q000737:chemistry / Q000378:metabolism
D009696:Nucleic Acids; D011506:Proteins; D012333:RNA, Messenger; D004247:DNA