A new antitumor antibiotic product, demethylchartreusin. Isolation and biological activities.
A new antitumor antibiotic, 3''-demethylchartreusin was isolated from the culture broth of Streptomyces chartreusis, as a minor component of crude chartreusin. It is structurally related to chartreusin, containing same aglycone of chartreusin, but different sugar moieties. 3''-Demethylchartreusin exhibits some potent inhibitory activities against murine tumors.
Aoyama
Y
Y
Biochemistry Research Laboratory, Ishihara Sangyo Kaisha, Ltd., Shiga, Japan.
Katayama
T
T
Yamamoto
M
M
Tanaka
H
H
Kon
K
K
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001578:Benzopyrans / Q000302:isolation & purification / Q000494:pharmacology; D005285:Fermentation; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology; D051379:Mice; D013302:Streptomyces / Q000378:metabolism
D000903:Antibiotics, Antineoplastic; D001578:Benzopyrans; D006027:Glycosides; C076082:3''-demethylchartreusin