Hypolipidemic activity of Achyranthus aspera Linn in normal and triton induced hyperlipemic rats.
The alcoholic extract of A. aspera, at 100 mg/kg dose lowered serum cholesterol (TC), phospholipid (PL). triglyceride (TG) and total lipids (TL) levels by 60, 51, 33 and 53% respectively in triton induced hyperlipidemic rats. The chronic administration of this drug at the same doses to normal rats for 30 days, lowered serum TC, PL, TG and TL by 56, 62, 68 and 67% respectively followed by significant reduction in the levels of hepatic lipids. The faecal excretion of cholic acid and deoxycholic acid increased by 24 and 40% respectively under the action of this drug. The possible mechanism of action of cholesterol lowering activity of A. aspera may be due to rapid excretion of bile acids causing low absorption of cholesterol.
Khanna
A K
AK
Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
Chander
R
R
Singh
C
C
Srivastava
A K
AK
Kapoor
N K
NK
D000818:Animals; D002784:Cholesterol / Q000097:blood; D006949:Hyperlipidemias / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D010743:Phospholipids / Q000097:blood; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D011092:Polyethylene Glycols; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000097:blood
D000960:Hypolipidemic Agents; D010743:Phospholipids; D010936:Plant Extracts; D014280:Triglycerides; D011092:Polyethylene Glycols; D002784:Cholesterol