Inhibitory effect of human chorionic gonadotropin (hCG) on HIV-1 transmission from lymphocytes to trophoblasts.
It has been demonstrated that human chorionic gonadotropin (hCG) inhibits HIV production in vitro, suggesting that this soluble placental glycoprotein can control viral replication and spread in vivo. hCG--the major product of fetal trophoblasts--was tested on an in vitro model consisting of choriocarcinoma-derived ENAMI trophoblasts exposed to HIV-infected MOLT-4 lymphocytes. The results show a U-shaped antiviral dose-effect and suggest that hCG may contribute to protection against intrauterine transmission of HIV-1.
Bourinbaiar
A S
AS
Population Council, Center for Biomedical Research, New York, NY 10021.
Nagorny
R
R
D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D004797:Enzyme-Linked Immunosorbent Assay; D016655:HIV Core Protein p24 / Q000032:analysis; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008214:Lymphocytes / Q000382:microbiology*; D014327:Trophoblasts / Q000382:microbiology*; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D006063:Chorionic Gonadotropin; D016655:HIV Core Protein p24