title: Pituitary gigantism.
abstract: Pituitary gigantism is a rare condition whose association with McCune-Albright syndrome suggests that mutations in alpha-subunit of a Gs protein are an important cause of this condition. In addition to somatotroph adenoma, it is now recognized that somatotroph hyperplasia can also result from increased levels of growth hormone-releasing hormone. Transgenic rats with hypersomatotrophism are prone to renal and hepatic pathology.
authors.affiliation: Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri.
authors.forename: W H
authors.initials: WH
authors.lastname: Daughaday
mesh_terms: D000236:Adenoma / Q000150:complications* / Q000378:metabolism; D000818:Animals; D030801:Animals, Genetically Modified; D001827:Body Height; D003937:Diagnosis, Differential; D005877:Gigantism / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D013006:Growth Hormone / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D006801:Humans; D010911:Pituitary Neoplasms / Q000150:complications* / Q000378:metabolism
chemical_list: D013006:Growth Hormone