title: [Previous dissociative psychiatric disorder and status epilepticus in a case of acute HIV infection].
abstract: We described an 18 old homosexual man who after 5 days developed a neurologic picture associated with Human Immunodeficiency Viruses (HIV) seroconversion. The patient had developed a dissociative psychiatric disorder 6 months before, and after resolution of the acute neurologic disease a mild neuro-psychiatric disorder remained. After mononucleosis-like syndrome of three weeks, the patient developed a meningo-encephalitic process 48 h post admission. He evolved with tonic seizures and twilight state and was admitted into Intensive Care Unit because of epileptic status and deep coma. Evolution was favourable after 72 h of treatment with acyclovir and antiepileptic drugs. Laboratory data showed an inverted T4/T8 ratio and seroconversion to HIV-antibodies and p24-antigen both in serum and CSF. These observations confirm the existence of psychiatric as well neurological alterations in acute HIV infection, and also the significance of p24-antigen and Western-Blot in serum and CSF in showing the seroconversion profile.
authors.affiliation: Servicio de Medicina Interna, Hospital Clínico Universitario, Facultad de Medicina, Valladolid.
authors.forename: J
authors.initials: J
authors.lastname: Arias Mayorga
authors.forename: M A
authors.initials: MA
authors.lastname: del Pozo Pérez
authors.forename: R
authors.initials: R
authors.lastname: Ortiz de Lejarazu
authors.forename: J
authors.initials: J
authors.lastname: Eiros Bouza
authors.forename: A
authors.initials: A
authors.lastname: Marañón Cabello
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D015153:Blotting, Western; D016516:CD4-CD8 Ratio; D004213:Dissociative Disorders / Q000150:complications* / Q000175:diagnosis; D015483:HIV Antibodies / Q000097:blood; D016655:HIV Core Protein p24 / Q000097:blood / Q000134:cerebrospinal fluid; D015658:HIV Infections / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications* / Q000276:immunology; D015497:HIV-1 / Q000302:isolation & purification* / Q000472:pathogenicity; D006564:Herpesviridae / Q000276:immunology; D006801:Humans; D007244:Infectious Mononucleosis / Q000382:microbiology*; D008297:Male; D008590:Meningoencephalitis / Q000134:cerebrospinal fluid / Q000150:complications / Q000382:microbiology*; D013226:Status Epilepticus / Q000209:etiology*
chemical_list: D000914:Antibodies, Viral; D015483:HIV Antibodies; D016655:HIV Core Protein p24
vernacular_title: Trastorno disociativo psiquiátrico previo y status epiléptico en un caso de infección aguda por VIH.