Cardiovascular effect of a senso (toad venom) - containing drug in anesthetized dogs (2): Influence of propranolol.
Effects of a Senso (toad venom)-containing drug KY on systemic hemodynamics were examined, and participation of beta-adrenoceptor in its action was evaluated by using propranolol in anesthetized dogs. KY produced a positive inotropic action, and decreased total peripheral (TPR) and coronary vascular resistances (CR), while renal vascular resistance (RR) was increased. After propranolol, KY significantly increased TPR, CR, vertebral vascular resistance and RR. KY-induced positive inotropic action was partly diminished but not abolished by beta-blockade. These results indicate that the beta-adrenergic action may be involved in the vasodilating effect of KY and partly in the positive inotropic action.
Ojiri
Y
Y
Department of Pharmacology, School of Medicine, Faculty of Medicine, University of the Ryukyus.
Chibana
T
T
Noguchi
K
K
Sakanashi
M
M
D000664:Amphibian Venoms / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D004336:Drug Antagonism; D004353:Drug Evaluation, Preclinical; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008516:Medicine, Chinese Traditional; D011433:Propranolol / Q000494:pharmacology*; D014664:Vasodilation / Q000187:drug effects*
D000664:Amphibian Venoms; D011433:Propranolol; D007545:Isoproterenol