[Diphasic effect of thyrotropin on the uptake and absorption of iodine-131 by thyroid cell culture].
The studies were performed on the primary culture of thyroid cells of newborn pigs. It was shown that thyroid-stimulating hormone (TSH) within the first 12th of its action inhibited uptake and organification of iodine-131. A negative influence of TSH on 131I uptake was retained both with its simultaneous introduction into the culture medium and with 30 min interval as well as when conducting experiments on the 1st, 3d, 5th and 7th days of cultivation. Previous 72h incubation with TSH sufficient for activation of all the links of iodine transport caused an increase in 131I uptake and organification.
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D000042:Absorption / Q000187:drug effects; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D002478:Cells, Cultured; D003470:Culture Media; D003864:Depression, Chemical; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes / Q000378:metabolism*; D008954:Models, Biological; D013552:Swine / Q000378:metabolism*; D013961:Thyroid Gland / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D013972:Thyrotropin / Q000494:pharmacology*
D003470:Culture Media; D007457:Iodine Radioisotopes; D013972:Thyrotropin
Dvokhfaznyĭ efekt tyreotropnoho hormonu na pohlynannia ta organifikatsiiu ĭodu-131 kul'turoiu klityn shchytovidnoï zalozy.