Connectin: a homophilic cell adhesion molecule expressed on a subset of muscles and the motoneurons that innervate them in Drosophila.
Each abdominal hemisegment in the Drosophila embryo contains a stereotyped array of 30 muscles, each specifically innervated by one or a few motoneurons. We screened 11,000 enhancer trap lines, isolated several expressing beta-galactosidase in small subsets of muscle fibers prior to innervation, and identified two of these as inserts in connectin and Toll, members of the leucine-rich repeat gene family. Connectin contains a signal sequence, ten leucine-rich repeats, and a putative phosphatidylinositol membrane linkage; in S2 cells, connectin can mediate homophilic cell adhesion. Connectin is expressed on the surface of eight muscles, the motoneurons that innervate them, and several glial cells along the pathways leading to them. During synapse formation, the protein localizes to synaptic sites; afterward, it largely disappears. Thus, connectin is a novel cell adhesion molecule whose expression suggests a role in target recognition.
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Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley 94720.
Mahajan
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Goodman
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D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015815:Cell Adhesion Molecules / Q000032:analysis / Q000737:chemistry / Q000235:genetics*; D003001:Cloning, Molecular; D064211:Connectin; D004247:DNA; D004330:Drosophila / Q000196:embryology / Q000235:genetics*; D008969:Molecular Sequence Data; D009046:Motor Neurons / Q000737:chemistry*; D009124:Muscle Proteins / Q000032:analysis / Q000737:chemistry / Q000235:genetics*; D009132:Muscles / Q000737:chemistry* / Q000196:embryology; D011494:Protein Kinases; D016415:Sequence Alignment
D015815:Cell Adhesion Molecules; D064211:Connectin; D009124:Muscle Proteins; D004247:DNA; D011494:Protein Kinases