title: High-performance liquid chromatographic determination of the pi values of azol-N-yl substituents.
abstract: The pi (hydrophobic constant) values for 16 parent azoles (pyrrole, imidazole, pyrazole, four triazoles, two tetrazoles, indole, benzimidazole, 1H- and 2H-indazoles, 1H- and 2H-benzotriazoles, and carbazole) were calculated from the logarithms of the capacity factors (log k') determined by HPLC. The values thus obtained are discussed according to an additive model in which the number and position of pyridinelike nitrogen atoms and the annelation effect are considered.
authors.affiliation: Departamento de Química Orgánica, Universidad de Alcalá de Henares, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Alvarez-Builla
authors.forename: T
authors.initials: T
authors.lastname: Crespo
authors.forename: R
authors.initials: R
authors.lastname: Lopez
authors.forename: J
authors.initials: J
authors.lastname: Elguero
authors.forename: C
authors.initials: C
authors.lastname: Toiron
authors.forename: G I
authors.initials: GI
authors.lastname: Yranzo
mesh_terms: D001393:Azoles / Q000032:analysis* / Q000737:chemistry; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D012044:Regression Analysis; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D001393:Azoles