Brominated beta-carbolines from the marine tunicate Eudistoma album.
Chemical investigation of the cytotoxic EtOH extract of the marine tunicate Eudistoma album led to the isolation of three brominated beta-carbolines which were characterized by their spectral data. Two of them, eudistomin E, which is already known for its potent antiviral activity, and the novel compound eudistalbin A [1], were shown to possess cytotoxic activity (ED50 less than 5.0 ng and 3.2 micrograms/ml respectively) in vitro against the growth of KB human buccal carcinoma cells. The third compound, eudistalbin B [2], is a new inactive natural product.
Adesanya
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Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette, France.
Chbani
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Païs
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Debitus
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D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002243:Carbolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D000431:Ethanol / Q000737:chemistry; D006801:Humans; D007624:KB Cells; D014561:Urochordata / Q000737:chemistry*
D000970:Antineoplastic Agents; D002243:Carbolines; C076218:eudistalbin A; D000431:Ethanol; C076219:eudistomin E