Antioxidant activity of ubiquinone-3 in human low density lipoprotein.
The ability of ubiquinone-3, a short chain ubiquinone homologue, to prevent Cu2+ induced oxidation of human low density lipoprotein was investigated. The results are as follows: in the presence of ubiquinone-3 the extent of peroxidation, as determined by the formation of thiobarbituric acid reactive substances, was only one third of that found in its absence; the quinone can also prevent the fragmentation of apolipoprotein B-100 and the increase of the net negative surface charge of the particle.
Merati
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Fondazione Rivetti, Laboratorio di Biochimica e Biologia Molecolare, Milano, Italy.
Pasquali
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Vergani
C
C
Landi
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L
D053299:Apolipoprotein B-100; D001055:Apolipoproteins B / Q000378:metabolism*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003300:Copper / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D019327:Copper Sulfate; D004492:Edetic Acid / Q000494:pharmacology; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008077:Lipoproteins, LDL / Q000187:drug effects / Q000378:metabolism*; D008081:Liposomes; D010084:Oxidation-Reduction; D010713:Phosphatidylcholines / Q000378:metabolism; D013499:Surface Properties; D013858:Thiobarbiturates / Q000378:metabolism; D014451:Ubiquinone / Q000494:pharmacology*
D053299:Apolipoprotein B-100; D001055:Apolipoproteins B; D008077:Lipoproteins, LDL; D008081:Liposomes; D010713:Phosphatidylcholines; D013858:Thiobarbiturates; D014451:Ubiquinone; D003300:Copper; D004492:Edetic Acid; D019327:Copper Sulfate; C029684:thiobarbituric acid