title: Electrochemical characteristics of nitroheterocyclic compounds of biological interest. VIII. Stability of nitro radical anions from cyclic voltammetric studies.
abstract: The stability of the one electron addition product of four biologically important nitroheterocyclic compounds has been examined electrochemically. Using cyclic voltammetry the tendency of the nitro radical anion to undergo disproportionation was studied by two methods of analysis. The first was based on determining the voltammetric time-constant required for half of the reduction product, RNO2-., to react further. The second concerned the minimum volume of dimethylformamide which had to be added to the aqueous electrolytic medium to give a specific cyclic voltammetric response. Both methods were found to compare well with the results obtained for RNO2-. stabilities using a theoretically derived procedure for a second order reaction following a charge-transfer step. The use of these alternative approaches for quantifying the reactivity of reduction products is discussed. The time-constant method in particular may be useful in studying complex reaction pathways.
authors.affiliation: Chemotherapy Research Unit, Polytechnic of East London, U.K.
authors.forename: J H
authors.initials: JH
authors.lastname: Tocher
authors.forename: D I
authors.initials: DI
authors.lastname: Edwards
mesh_terms: D002701:Chloramphenicol / Q000737:chemistry*; D004126:Dimethylformamide; D004563:Electrochemistry; D005609:Free Radicals; D006207:Half-Life; D006571:Heterocyclic Compounds / Q000737:chemistry; D008795:Metronidazole / Q000737:chemistry*; D009574:Nitro Compounds / Q000737:chemistry; D009583:Nitrofurazone / Q000737:chemistry*; D011720:Pyrazoles / Q000737:chemistry*
chemical_list: D005609:Free Radicals; D006571:Heterocyclic Compounds; D009574:Nitro Compounds; D011720:Pyrazoles; D008795:Metronidazole; C062496:1-hydroxyethyl-4-nitropyrazole; D002701:Chloramphenicol; D004126:Dimethylformamide; D009583:Nitrofurazone