title: Clonidine transdermal system for treatment of spasticity in spinal cord injury.
abstract: Clonidine tablets have been used in the past for treatment of spasticity with some success. The use of clonidine, however, has been limited by adverse effects, mainly hypotension. Over a two-year period, 17 patients were started on clonidine transdermal delivery system. They were followed for up to 18 months. Twelve of the 17 patients had a beneficial response and have continued on the patch. In ten of these 12 patients, other antispasticity drugs were either reduced or discontinued. In another three of the 17 patients, the response was good, but the patch was discontinued. No patient demonstrated persistent problematic hypotension. Clonidine Transdermal Patch appears to be an effective treatment for spasticity after a spinal cord injury. Adverse effects appear to be minimized using this mode of delivery.
authors.affiliation: Wayne State University School of Medicine, Detroit, MI.
authors.forename: S I
authors.initials: SI
authors.lastname: Weingarden
authors.forename: J G
authors.initials: JG
authors.lastname: Belen
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000368:Aged; D003000:Clonidine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D009128:Muscle Spasticity / Q000188:drug therapy* / Q000209:etiology; D013119:Spinal Cord Injuries / Q000150:complications*
chemical_list: D003000:Clonidine