title: Tiletamine hydrochloride in combination with zolazepam hydrochloride as an anaesthetic agent in sheep.
abstract: The anaesthetic effects of Zoletil, a 1:1 combination of tiletamine and zolazepam, was evaluated in 10 sheep. The optimum dose of this preparation was found to be 12 mg kg-1. It produced rapid induction, cataleptoid anaesthesia and smooth recovery with a minimal effect on blood pressure. Individual sheep, however, displayed variable reactions to the anaesthetic. Atropine premedication at 0.04 mg kg-1 did not have any significant effect on either heart rate or blood pressure when compared to Zoletil alone.
authors.affiliation: Department of Physiology, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, Republic of South Africa.
authors.forename: J H
authors.initials: JH
authors.lastname: Taylor
authors.forename: C J
authors.initials: CJ
authors.lastname: Botha
authors.forename: G E
authors.initials: GE
authors.lastname: Swan
authors.forename: M S
authors.initials: MS
authors.lastname: Mülders
authors.forename: M J
authors.initials: MJ
authors.lastname: Grobler
mesh_terms: D000777:Anesthetics / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004338:Drug Combinations; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D012756:Sheep / Q000502:physiology*; D013992:Tiletamine / Q000494:pharmacology*; D015041:Zolazepam / Q000494:pharmacology*
chemical_list: D000777:Anesthetics; D004338:Drug Combinations; C006131:tiletamine, zolazepam drug combination; D013992:Tiletamine; D015041:Zolazepam