title: Bile acid malabsorption caused by gastrointestinal motility dysfunction? An investigation of gastrointestinal disturbances in familial amyloidosis with polyneuropathy.
abstract: Gastrointestinal dysfunction due to autonomous neuropathy is a complication described in various diseases such as diabetes mellitus, multiple sclerosis, and familial amyloidosis with polyneuropathy. We present the results of a prospective investigation of bile acid malabsorption in 17 patients with familial amyloidosis by means of 75Se-labelled homocholic-tauro acid (SeHCAT). The diagnosis was in all cases verified by the DNA test for mutation of transthyretin in position 30. Small-intestinal biopsy specimens were examined for deposits of amyloid, and the presence of gastric retention was evaluated by gastroscopy. In addition, the patients were investigated for bacterial overgrowth by means of the bile acid breath test (BABT). A high frequency of abnormal BABT results (44%) was encountered. However, 65% also had abnormal low SeHCAT values, indicating bile acid malabsorption. Only two patients had abnormal BABT and normal SeHCAT results, indicating bacterial contamination of the small intestine. Bile acid losses increased with the duration of gastrointestinal symptoms. Significantly lower SeHCAT values were encountered in patients with gastric retention, whereas the occurrence of amyloid deposits in small-intestinal biopsy specimens was without effect on SeHCAT retention. Bile acid malabsorption is frequently encountered in familial amyloidosis with polyneuropathy and seems to be more closely associated with gastrointestinal motility dysfunction than with amyloid deposits in the intestinal mucosa.
authors.affiliation: Dept. of Medicine, University Hospital, Umeå, Sweden.
authors.forename: O
authors.initials: O
authors.lastname: Suhr
authors.forename: A
authors.initials: A
authors.lastname: Danielsson
authors.forename: L
authors.initials: L
authors.lastname: Steen
mesh_terms: D000686:Amyloidosis / Q000150:complications / Q000235:genetics*; D001342:Autonomic Nervous System Diseases / Q000150:complications / Q000235:genetics*; D001647:Bile Acids and Salts / Q000378:metabolism*; D001944:Breath Tests; D005260:Female; D005769:Gastrointestinal Motility / Q000502:physiology*; D006801:Humans; D007421:Intestine, Small / Q000382:microbiology / Q000473:pathology; D008286:Malabsorption Syndromes / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D012644:Selenium Radioisotopes; D013656:Taurocholic Acid / Q000031:analogs & derivatives
chemical_list: D001647:Bile Acids and Salts; D012644:Selenium Radioisotopes; D013656:Taurocholic Acid; C033638:23-seleno-25-homotaurocholic acid