Maternal and neonatal thyroid function at birth in an area of marginally low iodine intake.
Thyroid function was evaluated in cord serum of healthy full-term newborns and compared to that of mothers immediately after parturition. The study was carried out in an area without overt iodine deficiency, but with a marginal iodine supply (less than 100 micrograms/day in 80% of women). The aim of the study was to delineate the interrelationships between the thyroid statuses of mother and child at birth. Maternal thyroid function was characterized at delivery by relative hypothyroxinemia; increased T3/T4 ratios, indicating preferential T3 secretion; slightly increased TSH levels within the normal range in 97% of women; increased serum thyroglobulin (TG) values, which were above normal in 60% of women; and also goiter formation in almost 10% of women. The findings indicated glandular stimulation and confirmed our earlier reports that pregnancy constitutes a stress for the maternal thyroid economy, enhanced by the limited availability of iodine in the diet. By contrast, newborns showed a strikingly distinct pattern: there was no relative hypothyroxinemia and free T4 levels were significantly higher than in the respective mothers (19.4 vs. 14.7 pmol/L; P less than 0.001). In spite of these differences, however, mean neonatal TSH and TG levels were significantly higher than maternal values, respectively 6.0 vs. 1.9 mU/L for TSH (P less than 0.001) and 70 vs. 40 micrograms/L for TG (P less than 0.001). Furthermore, neonatal TG and TSH levels increased in parallel and were highly correlated with maternal data, suggesting a regulatory link between both thyroid economies. The results suggested that the common regulatory link is the limited availability of the iodine supply. In conclusion, the present study demonstrates that even in conditions with a marginally low iodine intake, pregnancy constitutes a stimulus for both the maternal and newborn thyroids. Changes in both groups are associated and the abnormalities in TSH and TG are amplified in the newborns. The TSH and TG alterations at birth in full-term healthy newborns, associated with similar alterations in maternal thyroid function, provide evidence for a common stimulatory factor, relative iodine deficiency. The data emphasize the hypersensitivity of neonatal thyroid function to marginal iodine deficiency and point to the need to increase the iodine supply in groups at risk, such as women during pregnancy, and also newborns in the perinatal period.
Glinoer
D
D
Department of Endocrinology, Saint-Pierre Hospital, Université Libre de Bruxelles, Belgium.
Delange
F
F
Laboureur
I
I
de Nayer
P
P
Lejeune
B
B
Kinthaert
J
J
Bourdoux
P
P
D015331:Cohort Studies; D036861:Delivery, Obstetric; D004032:Diet; D005260:Female; D006801:Humans; D007231:Infant, Newborn / Q000097:blood / Q000502:physiology*; D007455:Iodine / Q000008:administration & dosage*; D011247:Pregnancy / Q000097:blood / Q000502:physiology*; D011446:Prospective Studies; D013954:Thyroglobulin / Q000097:blood; D013961:Thyroid Gland / Q000502:physiology*; D013963:Thyroid Hormones / Q000097:blood; D013975:Thyroxine-Binding Proteins / Q000032:analysis
D013963:Thyroid Hormones; D013975:Thyroxine-Binding Proteins; D013954:Thyroglobulin; D007455:Iodine