title: What differentiates antiestrogen-liganded vs estradiol-liganded estrogen receptor action?
abstract: This paper provides an annotated summary of the current literature detailing what is known about the interaction of antiestrogen-liganded estrogen receptor (ER) vs estradiol-liganded ER with DNA in vitro and in vivo. It describes the current models of the mechanism by which antiestrogen-liganded ER blocks transcription of certain estrogen-regulated genes.
authors.affiliation: Department of Biochemistry, University of Rochester Medical Center, New York 14642.
authors.forename: C M
authors.initials: CM
authors.lastname: Klinge
authors.forename: R A
authors.initials: RA
authors.lastname: Bambara
authors.forename: R
authors.initials: R
authors.lastname: Hilf
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004958:Estradiol / Q000378:metabolism*; D004965:Estrogen Antagonists / Q000378:metabolism*; D005260:Female; D005809:Genes, Regulator; D006801:Humans; D008024:Ligands; D008954:Models, Biological; D011960:Receptors, Estrogen / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D004268:DNA-Binding Proteins; D004965:Estrogen Antagonists; D008024:Ligands; D011960:Receptors, Estrogen; D004958:Estradiol