Etoposide microcrystals suspended in oil: a new dosage form to peritoneal carcinomatosis in mice.
Etoposide microcrystals suspended in oil (ETOP-OIL) were examined for their therapeutic effects on peritoneal carcinomatosis in mice. Two days after intraperitoneal inoculation with 10(5) P388 leukemia cells/mouse to CDF1 male mice, etoposide at 10-80 mg/kg was administered intraperitoneally in bolus in the form of ETOP-OIL or in the aqueous solution form. In every dose, the survival curve of the mice given ETOP-OIL was statistically significantly improved in spite of its small lethal toxicity, as compared with those given the identical dose of etoposide aqueous solution.
Hagiwara
A
A
First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Takahashi
T
T
Sasabe
T
T
Ito
M
M
Lee
M
M
Sakakura
C
C
Shoubayashi
S
S
Tashima
S
S
Muranishi
S
S
D000818:Animals; D002277:Carcinoma / Q000188:drug therapy*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D005047:Etoposide / Q000008:administration & dosage* / Q000009:adverse effects; D007274:Injections, Intraperitoneal; D007941:Leukemia P388 / Q000188:drug therapy / Q000473:pathology; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D009821:Oils; D010534:Peritoneal Neoplasms / Q000188:drug therapy*; D013535:Suspensions
D009821:Oils; D013535:Suspensions; D005047:Etoposide