Renal amyloidosis in a family of beagles.
Renal amyloidosis was confirmed in 6 related male and female Beagles, ranging in age from 5 to 11 years. The most commonly reported signs of illness included lethargy, anorexia, vomiting, and weight loss. Common clinicopathologic abnormalities were normocytic, normochromic anemia; hypoalbuminemia; azotemia; hypercholesterolemia; proteinuria; and urine specific gravity values below the normal range. Histologic examination of renal tissue from the 6 Beagles revealed moderate to severe glomerular amyloidosis with inconsistently observed mild medullary interstitial amyloidosis. Congo red-stained kidney sections from 4 of 4 affected dogs were potassium permanganate-sensitive, suggestive of reactive amyloidosis. Hereditary predisposition for renal amyloidosis was suspected in these Beagles.
Bowles
M H
MH
Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, Oklahoma State University, Stillwater 74078.
Mosier
D A
DA
D000686:Amyloidosis / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D001806:Blood Urea Nitrogen; D004283:Dog Diseases / Q000235:genetics* / Q000473:pathology; D004285:Dogs; D005260:Female; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D008297:Male; D010375:Pedigree; D011507:Proteinuria / Q000662:veterinary; D012709:Serum Albumin / Q000032:analysis; D013046:Specific Gravity; D014556:Urine / Q000737:chemistry
D012709:Serum Albumin