title: Selenium and glutathione peroxidase levels in premature infants in a low selenium community (Christchurch, New Zealand).
abstract: By world standards, the selenium status of the adult population of Christchurch, New Zealand is low. To determine the status of infants undergoing neonatal intensive care, plasma and red cell selenium and glutathione peroxidase levels were measured in infants admitted to the regional neonatal unit. Plasma levels in all newborn infants were one third to one half those in adults. Premature infants had levels significantly lower than those in cord blood from term infants, but their levels were not different from those of term infants admitted to the unit. There were no differences between adult and infant red cell levels. The premature infants remaining in the neonatal unit showed dramatic decreases in plasma selenium and glutathione peroxidase with age, with many infants having selenium levels of less than 0.13 mumol/L (10 micrograms/L). Low levels were seen in infants fed orally as well as those on parenteral nutrition. Thus, the low selenium status of New Zealanders is associated with particularly low selenium levels in premature infants. Because these infants have a high risk for oxidative diseases such as bronchopulmonary dysplasia (chronic lung disease) and retinopathy of prematurity, the possibility that these conditions are more serious in the New Zealand population needs to be assessed and consideration given to dietary supplementation.
authors.affiliation: Department of Pathology, Christchurch School of Medicine, Christchurch Hospital, New Zealand.
authors.forename: K B
authors.initials: KB
authors.lastname: Sluis
authors.forename: B A
authors.initials: BA
authors.lastname: Darlow
authors.forename: P M
authors.initials: PM
authors.lastname: George
authors.forename: N
authors.initials: N
authors.lastname: Mogridge
authors.forename: B A
authors.initials: BA
authors.lastname: Dolamore
authors.forename: C C
authors.initials: CC
authors.lastname: Winterbourn
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D000367:Age Factors; D001997:Bronchopulmonary Dysplasia / Q000209:etiology; D004032:Diet; D004912:Erythrocytes / Q000378:metabolism; D005312:Fetal Blood / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000097:blood; D007234:Infant, Premature / Q000097:blood; D009520:New Zealand; D009752:Nutritional Status; D012643:Selenium / Q000008:administration & dosage / Q000097:blood / Q000172:deficiency; D008895:Milk, Human
chemical_list: D005979:Glutathione Peroxidase; D012643:Selenium