title: Saline resuscitation after fixed-volume hemorrhage. Role of resuscitation volume and rate of infusion.
abstract: The authors have reported previously that small-volume resuscitation (1.8 x bled volume) with 0.9% NaCl restores blood volume and attenuates hormonal responses after large hemorrhage without correction of arterial hypotension. The authors studied the role of rate of infusion in this observation in chronically prepared dogs (aortic flow probe, right atrial pressure and volume, and arterial catheters) after 30% hemorrhage (24.1 +/- 0.4 mL/kg). After 30 minutes, subjects were observed either without treatment (no resuscitation) or with infusion of 43 mL/kg 0.9% NaCl over 3 hours by one of three protocols: (1) impulse infusion over 10 minutes, (2) variable rate infusion, bolus with tapering infusion, or (3) constant rate infusion. Significant improvement in cardiac output and in blood volume and significant decreases of vasopressin and arterial catecholamines were observed in all fluid-treated groups. This benefit was relatively independent of rate of infusion, although impulse infusion produced greater early improvement, which dissipated with time, and constant rate infusion produced better late results. In none of the fluid-treated groups were these improvements reflected in improved mean arterial pressure compared with the no resuscitation group. The authors conclude that small-volume, slow-rate saline infusion produces physiologic benefits that cannot be assessed by easily measured clinical parameters. Thus, early resuscitation after trauma could aid patients even if arterial pressure is unchanged. This benefit might be even greater in patients with uncontrolled bleeding because arterial pressure, and hence bleeding, may not be increased by resuscitation of this type. A reassessment of the value of prehospital fluid resuscitation in the injured patient is warranted.
authors.affiliation: Department of Surgery, University of Maryland, School of Medicine, Baltimore.
authors.forename: M P
authors.initials: MP
authors.lastname: Lilly
authors.forename: G J
authors.initials: GJ
authors.lastname: Gala
authors.forename: D E
authors.initials: DE
authors.lastname: Carlson
authors.forename: B E
authors.initials: BE
authors.lastname: Sutherland
authors.forename: D S
authors.initials: DS
authors.lastname: Gann
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood; D001810:Blood Volume / Q000502:physiology; D004285:Dogs; D004837:Epinephrine / Q000097:blood; D005440:Fluid Therapy / Q000379:methods*; D006439:Hemodynamics / Q000502:physiology; D006470:Hemorrhage / Q000628:therapy*; D007262:Infusions, Intravenous / Q000379:methods; D012151:Resuscitation / Q000379:methods*; D012965:Sodium Chloride / Q000008:administration & dosage*
chemical_list: D001127:Arginine Vasopressin; D012965:Sodium Chloride; D004837:Epinephrine