title: Transcription factors: positive and negative regulators of cell growth and disease.
abstract: Recent advances in our understanding of transcription factors that regulate RNA polymerase II transcribed genes are described. This review considers the role of alternate protein-protein interactions to yield positive or negative regulation, the consequences of deregulated factor activity on cell function and approaches to establish factor-binding specificities.
authors.affiliation: Department of Biochemistry, Molecular and Cell Biology, Northwestern University, Evanston, Illinois.
authors.forename: R I
authors.initials: RI
authors.lastname: Morimoto
mesh_terms: D000818:Animals; D001665:Binding Sites; D002451:Cell Compartmentation; D002455:Cell Division / Q000235:genetics* / Q000502:physiology; D004247:DNA / Q000378:metabolism; D004194:Disease / Q000209:etiology; D014176:Protein Biosynthesis; D012326:RNA Splicing; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*
chemical_list: D014157:Transcription Factors; D004247:DNA