title: Arterial pH and carbon dioxide tension as indicators of tissue perfusion during cardiac arrest in a canine model.
abstract: METHODS
  Previous studies have shown that Paco2 and end-tidal CO2 reflect coronary artery perfusion pressures during cardiac arrest. We investigated the relationship of coronary artery perfusion pressure to central arterial pH and Paco2 values during resuscitation from cardiac arrest in a canine model. Twenty-four mongrel dogs were block randomized to three different resuscitation groups after induction of ventricular fibrillation and cardiac arrest: a) standard cardiopulmonary resuscitation (CPR) and advanced life support (n = 8); b) cardiopulmonary bypass (n = 8); or c) open-chest CPR (n = 8). Central arterial blood gases and perfusion pressures were monitored during cardiac arrest and during resuscitation.
  
  
  RESULTS
  Prearrest blood gases and hemodynamic values were similar between groups. Sixteen dogs from all three groups were successfully resuscitated. Survivors had significantly higher coronary artery perfusion pressure (p = .03), Paco2 (p = .015), and lower pH (p = .01) values than nonsurvivors. There was no correlation of pH and Paco2 during mechanical external CPR. However, after institution of the different resuscitation techniques, pH and Paco2 each showed a statistically significant correlation (r2 = .50 and .33, respectively) with coronary artery perfusion pressure.
  
  
  CONCLUSIONS
  Central arterial pH and Paco2 monitoring during cardiac arrest may reflect the adequacy of tissue perfusion during resuscitation and may predict resuscitation outcome from ventricular fibrillation.
authors.affiliation: Department of Emergency Medicine, Wright State University School of Medicine, Dayton, OH.
authors.forename: M G
authors.initials: MG
authors.lastname: Angelos
authors.forename: D J
authors.initials: DJ
authors.lastname: DeBehnke
authors.forename: J E
authors.initials: JE
authors.lastname: Leasure
mesh_terms: D000818:Animals; D001158:Arteries; D002245:Carbon Dioxide / Q000097:blood*; D002315:Cardiopulmonary Bypass; D016887:Cardiopulmonary Resuscitation / Q000379:methods; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D006323:Heart Arrest / Q000097:blood* / Q000503:physiopathology / Q000628:therapy; D006439:Hemodynamics; D006863:Hydrogen-Ion Concentration; D008297:Male; D010313:Partial Pressure; D011897:Random Allocation; D013997:Time Factors; D014693:Ventricular Fibrillation / Q000097:blood / Q000503:physiopathology / Q000628:therapy
chemical_list: D002245:Carbon Dioxide