[Dynamic changes of fibronectin, DNA and morphology of the nuclei of experimental hepatoma in rats].
The dynamic changes of fibronectin (FN) content and nuclear features (DNA content, morphological parameters) during the development of hepatoma induced by 3'-Me-DAB were studied via computer-assisted image analysis. The results showed that the amount of FN decreased progressively and even disappeared completely during hepatocarcinogenesis. The difference between distinctive foci or nodules was highly significant (P less than 0.0001) and the DNA content was also increased coincidently during the same process.
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Department of Pathology, Sun Yet-sen Medical University, Guangzhou.
D000818:Animals; D004273:DNA, Neoplasm / Q000378:metabolism*; D005353:Fibronectins / Q000378:metabolism*; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D008749:Methyldimethylaminoazobenzene / Q000031:analogs & derivatives; D051381:Rats; D011919:Rats, Inbred Strains
D004273:DNA, Neoplasm; D005353:Fibronectins; C032237:3'-hydroxymethyl-4-(dimethylamino)azobenzene; D008749:Methyldimethylaminoazobenzene