title: Cost-effectiveness comparison of single and multiple-dose antibiotic treatment of lower uncomplicated urinary tract infections.
abstract: This study analyzed the cost-effectiveness of antibiotic treatments of different durations for acute cystitis in non-pregnant females. Questionnaires were sent to 400 practitioners evenly distributed throughout Italy. Data are reported from 2,069 patients. The clinical bacteriological efficacy at 10-15 days was 86.4% for single-dose treatment with fosfomycin-trometamol (FT), and 81.8% for the multiple-dose antibiotics group (MDAG). Disappearance of symptoms occurred in 2.1 days with FT and 3.4 days with MDAG. With FT 93.8% of patients were free of adverse events and 86.9% with MDAG. Analysis of the cost-effectiveness indicators for cure rate and absence of adverse events showed that treatment costs were similar for all antibiotics. FT needed less time interval for symptoms to disappear with a slightly higher cost than for MDAG, which had a better cost/effectiveness ratio.
authors.affiliation: Institute of Biometrics, University of Milan, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Capri
authors.forename: G P
authors.initials: GP
authors.lastname: Del Bono
authors.forename: R
authors.initials: R
authors.lastname: Dellamano
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000191:economics*; D002511:Cephalosporins / Q000008:administration & dosage / Q000191:economics; D003362:Cost-Benefit Analysis; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000191:economics*; D005260:Female; D005578:Fosfomycin / Q000008:administration & dosage / Q000191:economics; D006801:Humans; D010878:Piperacillin / Q000008:administration & dosage / Q000191:economics; D013997:Time Factors; D014325:Tromethamine / Q000008:administration & dosage / Q000191:economics; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D014325:Tromethamine; D005578:Fosfomycin; D010878:Piperacillin