title: Isolation and characterization of new peptide antibiotics, plusbacins A1-A4 and B1-B4.
abstract: New antibiotics, plusbacins A1-A4 and B1-B4, were isolated from the culture broth of a strain of Pseudomonas sp. These antibiotics were isolated as a complex by column chromatographies on Diaion HP-20 and silica gel, and then separated by HPLC. They are amphoteric in nature. The hydrochlorides are obtained as colorless powders, soluble in methanol and alkaline water. From their physico-chemical properties, these antibiotics are presumed to be acyloctapeptides containing a lactone linkage, and their differences occur in amino acid and fatty acid residues. The antibiotics are active against Gram-positive bacteria in vitro and in vivo.
authors.affiliation: Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Shoji
authors.forename: H
authors.initials: H
authors.lastname: Hinoo
authors.forename: T
authors.initials: T
authors.lastname: Katayama
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.forename: T
authors.initials: T
authors.lastname: Tanimoto
authors.forename: T
authors.initials: T
authors.lastname: Hattori
authors.forename: I
authors.initials: I
authors.lastname: Higashiyama
authors.forename: H
authors.initials: H
authors.lastname: Miwa
authors.forename: K
authors.initials: K
authors.lastname: Motokawa
authors.forename: T
authors.initials: T
authors.lastname: Yoshida
mesh_terms: D000596:Amino Acids / Q000032:analysis; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D005227:Fatty Acids / Q000032:analysis; D005285:Fermentation; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011549:Pseudomonas / Q000145:classification / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D000900:Anti-Bacterial Agents; D005227:Fatty Acids; D010456:Peptides, Cyclic