Treatment of acutely infected arthroplasties with incision, drainage, and local antibiotics delivered via an implantable pump.
Twelve patients with acutely (symptomatic less than ten weeks) infected arthroplasties were treated with minimal debridement and intraarticular antibiotic, amikacin, delivered via an implantable pump. The infection was suppressed in ten cases. Intraarticular levels of amikacin were obtained in eight cases. These levels ranged from greater than 150 micrograms/ml to 1688 micrograms/ml. The systemic level of amikacin remained below 10 micrograms/ml in all but one case. Duration of hospitalization averaged 19 days. There were no significant toxic side effects to amikacin.
Perry
C R
CR
Washington University School of Medicine, St. Louis, Missouri.
Hulsey
R E
RE
Mann
F A
FA
Miller
G A
GA
Pearson
R L
RL
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000583:Amikacin / Q000008:administration & dosage* / Q000032:analysis / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy* / Q000601:surgery; D004322:Drainage; D005260:Female; D006621:Hip Joint / Q000000981:diagnostic imaging; D006622:Hip Prosthesis; D006801:Humans; D015918:Infusion Pumps, Implantable; D007719:Knee Joint / Q000000981:diagnostic imaging; D007720:Knee Prosthesis; D008297:Male; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000188:drug therapy* / Q000601:surgery; D011859:Radiography; D016896:Treatment Outcome
D000583:Amikacin