title: Enhanced induction of lymphokine-activated killer activity after lentinan administration in patients with gastric carcinoma.
abstract: In 15 patients with gastric carcinoma, peripheral blood mononuclear cells (PBM) were obtained serially before and 3, 5 and 7 days after lentinan administration. The generation of lymphokine-activated killer (LAK) activity, induced by in vitro activation of PBM with interleukin 2 (IL 2), was significantly augmented 5 days after a single intravenous dose of 2 mg lentinan, when compared with that before lentinan injection. Natural killer (NK) activity of PBM was also significantly enhanced 7 days after the drug injection. However, the distribution of lymphocyte subsets exhibited no significant change following lentinan administration.
authors.affiliation: Department of Surgery, Kyushu University, Beppu, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Arinaga
authors.forename: N
authors.initials: N
authors.lastname: Karimine
authors.forename: K
authors.initials: K
authors.lastname: Takamuku
authors.forename: S
authors.initials: S
authors.lastname: Nanbara
authors.forename: H
authors.initials: H
authors.lastname: Inoue
authors.forename: M
authors.initials: M
authors.lastname: Nagamatsu
authors.forename: H
authors.initials: H
authors.lastname: Ueo
authors.forename: T
authors.initials: T
authors.lastname: Akiyoshi
mesh_terms: D002469:Cell Separation; D002860:Chromium Radioisotopes; D005434:Flow Cytometry; D006801:Humans; D066298:In Vitro Techniques; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology*; D007912:Lentinan / Q000494:pharmacology*; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008213:Lymphocyte Activation; D013274:Stomach Neoplasms / Q000276:immunology*
chemical_list: D002860:Chromium Radioisotopes; D007912:Lentinan