Histiocytic lymphophagocytic panniculitis (Rosai-Dorfman disease): a case report.
A 68-year-old woman presented with a symmetrical enlargement of the face and submandibular area associated with essential thrombocytosis. Biopsy of the lesions revealed a septal and lobular panniculitis disclosing a lymphohistiocytic and plasma cell proliferation with lymphophagocytosis by histiocytes, compatible with Rosai-Dorfman disease. The lesions regressed spontaneously without therapy over a period of 4 months. Diagnosis was confirmed by electron-microscopic examination and immunocytochemical presence of S-100 antigen within the histiocytic cells. A 2-year follow-up did not demonstrate any evidence of recurrence.
Puppin
D
D
Clinique de Dermatologie, Hôpital Cantonal Universitaire de Genève, Suisse.
Chavaz
P
P
Harms
M
M
D000368:Aged; D005260:Female; D015618:Histiocytosis, Sinus / Q000150:complications / Q000473:pathology*; D006801:Humans; D008297:Male; D015434:Panniculitis / Q000150:complications / Q000473:pathology*; D013922:Thrombocytosis / Q000150:complications / Q000473:pathology*