Plasticity of binocular visual connections in the frog, Xenopus laevis: reversibility of effects of early visual deprivation.
In frogs, each lobe of the midbrain optic tectum receives two spatially aligned maps of binocular visual space, one through each eye. The map from the contralateral eye is the product of direct retinal input to the tectum, while that from the ipsilateral eye is mediated by a commissural system of connections that relays binocular visual information from one tectal lobe to the other. In Xenopus laevis, dark-reared from early life, the visuotectal map through the ipsilateral eye exhibits significant signs of disorder indicating that the normal development of the underlying "intertectal" system involves experience-dependent processes. Here we investigate the potential of this system for recovery from such deprivation-induced disruption. Three groups of animals were first dark-reared from embryonic stages until 3 months, 12 months or 2 years after metamorphosis. These short-, medium- and long-term periods of visual deprivation are associated with a progressive disturbance of the intertectal system (Grant and Keating 1989b). The animals then experienced 12-18 months in a normal visual environment, before an electrophysiological mapping experiment was carried out to reveal the status of their intertectal system. Quantitative analyses of the visuotopic order in the ipsilateral visuotectal map and of its spatial alignment with the map derived from the contralateral eye revealed that these features were completely normal in all 3 experimental groups. It is concluded that defects present in the intertectal system of dark-reared Xenopus can be repaired by subsequent visual experience, and that the reparative capacity is not limited either by the animal's age or by the existing degree of prior disruption.
Keating
M J
MJ
Division of Neurophysiology and Neuropharmacology, National Institute for Medical Research, Mill Hill, London, UK.
Dawes
E A
EA
Grant
S
S
D000818:Animals; D001931:Brain Mapping; D004594:Electrophysiology; D004625:Embryo, Nonmammalian; D009473:Neuronal Plasticity / Q000502:physiology*; D012683:Sensory Deprivation / Q000502:physiology*; D013477:Superior Colliculi / Q000033:anatomy & histology / Q000502:physiology; D015348:Vision, Binocular / Q000502:physiology*; D014795:Visual Pathways / Q000502:physiology*; D014982:Xenopus laevis