title: Successful pregnancy after total body irradiation and bone marrow transplantation for acute leukaemia.
abstract: We report successful pregnancies in two young women (aged 24 and 20 years) following allogeneic bone marrow transplantation (BMT) for acute non-lymphoblastic leukaemia. Conditioning therapy consisted of cyclophosphamide (120 mg/kg) and total body irradiation (TBI, 12 Gy) in 2 Gy fractions once daily for 6 days or twice daily for 3 days. Graft-versus-host disease prophylaxis was with methotrexate alone. Both women were amenorrhoeic after BMT and gonadal testing indicated hypergonadotrophic hypogonadism. Both women had normal pregnancies (2 years and 5 years after BMT) resulting in normal healthy infants. Previously successful pregnancy has been reported after TBI in three women in whom the TBI dose was less than 8 Gy. Our cases illustrate that normal outcome of pregnancy is possible at even higher doses of TBI.
authors.affiliation: Department of Paediatric Haematology/Oncology, Prince of Wales Hospital, Randwick, NSW Australia.
authors.forename: N
authors.initials: N
authors.lastname: Giri
authors.forename: M R
authors.initials: MR
authors.lastname: Vowels
authors.forename: A L
authors.initials: AL
authors.lastname: Barr
authors.forename: H
authors.initials: H
authors.lastname: Mameghan
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000532:radiotherapy / Q000601:surgery; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D010053:Ovary / Q000503:physiopathology / Q000528:radiation effects; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic; D011256:Pregnancy Outcome; D011879:Radiotherapy Dosage; D014916:Whole-Body Irradiation
chemical_list: D003520:Cyclophosphamide; D008727:Methotrexate