title: The influence of hyperglycemia on outcome of cerebral infarction.
abstract: OBJECTIVE
  To determine whether hyperglycemia in the acute stroke period is associated with worse survival and functional outcome after accounting for acute stress response and chronic hyperglycemia.
  
  
  METHODS
  Prospective, county-wide, multicenter cohort study.
  
  
  METHODS
  A community hospital, a university hospital, and a Veterans Affairs hospital.
  
  
  METHODS
  A cohort of 146 patients hospitalized with new atherothrombotic stroke.
  
  
  METHODS
  Admission blood glucose concentration, demographic characteristics of patients, 24-hour urinary catecholamine, serum cortisol, and glycosylated hemoglobin levels; outcomes included mortality and functional outcome (Barthel index and Fugl-Meyer score) at 5, 30, 90, and 180 days after stroke.
  
  
  RESULTS
  Of the 996 patients with possible acute stroke who were screened, 146 (15%) were eligible for and consented to participate in the study; in most cases, exclusion from study was based on the absence of acute, atherothrombotic stroke. Overall, no evidence was found of a significant univariate association between admission blood glucose level and survival (relative risk, 1.02; 95% Cl, 0.94 to 1.09) or functional outcome (univariate regression coefficient for adjusted Fugl-Meyer score at day 30, - 0.36; Cl, - 1.08 to 0.27). This absence of an association persisted after adjustment for significant predictors of outcome in a multivariate model.
  
  
  CONCLUSIONS
  These data do not support an association between level of glycemia and outcome from acute stroke.
authors.affiliation: Duke University, Durham, NC.
authors.forename: D B
authors.initials: DB
authors.lastname: Matchar
authors.forename: G W
authors.initials: GW
authors.lastname: Divine
authors.forename: A
authors.initials: A
authors.lastname: Heyman
authors.forename: J R
authors.initials: JR
authors.lastname: Feussner
mesh_terms: D000208:Acute Disease; D000368:Aged; D002395:Catecholamines / Q000652:urine; D002544:Cerebral Infarction / Q000150:complications / Q000401:mortality / Q000503:physiopathology*; D004185:Disability Evaluation; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006943:Hyperglycemia / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012044:Regression Analysis; D016019:Survival Analysis
chemical_list: D002395:Catecholamines; D006442:Glycated Hemoglobin; D006854:Hydrocortisone