pokkuri, a Drosophila gene encoding an E-26-specific (Ets) domain protein, prevents overproduction of the R7 photoreceptor.
Studies on sevenless and bride of sevenless genes have revealed that the R8 cell plays a key role in the fate of the R7 photoreceptor cell, presenting on its surface an inductive cue to which R7 responds. sev-independent induction of R7 cells has been reported in the seven-up mutation, which appears to transform R1 and R6 cells to R7 cells. We have induced recessive mutations in a gene pokkuri (pok; pokkuri is a Japanese word that means "dropping dead") that lead to overproduction of R7 cells with rather minor effects on outer photoreceptors and R8 cells. Pok protein may function as a transcription factor, as the predicted amino acid sequence contains a region similar to the consensus established for the E-26-specific (Ets) domain.
Tei
H
H
Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan.
Nihonmatsu
I
I
Yokokura
T
T
Ueda
R
R
Sano
Y
Y
Okuda
T
T
Sato
K
K
Hirata
K
K
Fujita
S C
SC
Yamamoto
D
D
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003433:Crosses, Genetic; D004268:DNA-Binding Proteins; D004330:Drosophila / Q000235:genetics* / Q000502:physiology; D005136:Eye Proteins / Q000235:genetics*; D005260:Female; D005796:Genes; D006580:Genetic Carrier Screening; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009030:Mosaicism; D010786:Photoreceptor Cells / Q000166:cytology / Q000502:physiology*; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D050787:Proto-Oncogene Protein c-ets-2; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D050783:Proto-Oncogene Proteins c-ets; D011519:Proto-Oncogenes; D012097:Repressor Proteins; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D015534:Trans-Activators; D014157:Transcription Factors
D004268:DNA-Binding Proteins; C107465:ERF protein, human; C494069:ETS2 protein, human; D005136:Eye Proteins; D050787:Proto-Oncogene Protein c-ets-2; D011518:Proto-Oncogene Proteins; D050783:Proto-Oncogene Proteins c-ets; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D011505:Protein-Tyrosine Kinases