Abnormalities of the autonomic nervous system of the duodenum in streptozotocin-induced diabetic rats.
The changes in sensitivity of the rat duodenum to ATP were examined in preparations from control rats and from rats with streptozotocin (STZ)-induced diabetes. ATP was able to relax the duodenum of control animals in a concentration-dependent manner and this relaxation was significantly increased in STZ-diabetic rats. In preparations from diabetic rats, relaxation responses to ATP were greater than those of age-matched control groups. These results suggest that functional changes or degeneration of non-adrenergic, non-cholinergic nerves in the myenteric plexus may occur in STZ-diabetic rats, and that these alterations may result in the increased sensitivity of the relaxation of the duodenum to ATP.
Kamata
K
K
Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
Sakamoto
A
A
Kasuya
Y
Y
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001341:Autonomic Nervous System / Q000503:physiopathology*; D001786:Blood Glucose / Q000378:metabolism; D003714:Denervation; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000503:physiopathology*; D004386:Duodenum / Q000294:innervation*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D000255:Adenosine Triphosphate