A new class of alkaloids from a dendrobatid poison frog: a structure for alkaloid 251F.
Alkaloids of a new class are present in skin extracts of the dendrobatid poison frog, Minyobates bombetes, of Colombia. The structure of the major alkaloid of this class, 251F, has been determined as a trimethylcyclopenta[b]quinolizidinemethanol 1 by nmr, gc-Ft-ir, and ms studies including ms-ms. At least nine congeners of 251F were detected in these extracts.
Spande
T F
TF
Laboratory of Bioorganic Chemistry, National Institute of Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892.
Garraffo
H M
HM
Yeh
H J
HJ
Pu
Q L
QL
Pannell
L K
LK
Daly
J W
JW
D000470:Alkaloids / Q000032:analysis* / Q000737:chemistry; D000818:Animals; D001001:Anura / Q000378:metabolism*; D003105:Colombia; D013058:Mass Spectrometry; D012867:Skin / Q000737:chemistry
D000470:Alkaloids