The effects of indomethacin on fibroblast chemotaxis.
1. Boyden chambers were used to investigate the effects of indomethacin on fibroblast chemotaxis to a conditioned medium. 2. It was determined that indomethacin did not inhibit, but enhanced fibroblast chemotaxis at a concentration of 10(-4) (91%)-10(-6) M (79%). 3. No significant difference was found between controls and cells treated with 10(-8)-10(-10) M indomethacin.
Kalmus
G W
GW
Department of Biology, East Carolina University, Greenville, NC 27858-4353.
Poulos
J E
JE
O'Rear
C W
CW
D016718:Arachidonic Acid / Q000378:metabolism; D002478:Cells, Cultured; D002633:Chemotaxis / Q000187:drug effects*; D005347:Fibroblasts / Q000187:drug effects*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male
D016718:Arachidonic Acid; D007213:Indomethacin