title: Dendritic regrowth of retinal ganglion cells in adult rats.
abstract: IN adult rat retinal ganglion cells, we investigated how their dendrites are maintained during axonal regeneration induced by a peripheral nerve (PN) graft. Intracellular Lucifer Yellow injection revealed that rapid dendritic retraction occurred immediately after axotomy and grafting. However, dendrites that probably sprouted after axotomy were often found in the regenerating ganglion cells, and their dendritic field tended to recover in area by 3 months after grafting. Although such dendrites were also found in an axotomized cell receiving no PN graft, they are much more frequently observed in the regenerating cells. Therefore, a PN graft can facilitate the rat ganglion cells to regrow their dendrites.
authors.affiliation: Department of Physiology, Osaka University Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tabata
authors.forename: Y
authors.initials: Y
authors.lastname: Fukuda
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology* / Q000648:ultrastructure; D003712:Dendrites / Q000502:physiology* / Q000648:ultrastructure; D005456:Fluorescent Dyes; D007546:Isoquinolines; D008297:Male; D009416:Nerve Regeneration; D009900:Optic Nerve / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012165:Retinal Ganglion Cells / Q000166:cytology / Q000502:physiology*; D012584:Sciatic Nerve / Q000502:physiology / Q000637:transplantation
chemical_list: D005456:Fluorescent Dyes; D007546:Isoquinolines; C017475:lucifer yellow