title: Safety and immunogenicity of a booster dose of Vibrio cholerae CVD 103-HgR live oral cholera vaccine in Swiss adults.
abstract: Adult volunteers received a booster dose (4 x 10(8) CFU) of attenuated Vibrio cholerae CVD 103-HgR oral vaccine 15 or 24 months after primary immunization. The immune response was modest, presumably due to rapid clearance of the vaccine strain by a primed immune system.
authors.affiliation: Swiss Serum and Vaccine Institute, CH-3001 Berne.
authors.forename: S J
authors.initials: SJ
authors.lastname: Cryz
authors.forename: M M
authors.initials: MM
authors.lastname: Levine
authors.forename: G
authors.initials: G
authors.lastname: Losonsky
authors.forename: J B
authors.initials: JB
authors.lastname: Kaper
authors.forename: B
authors.initials: B
authors.lastname: Althaus
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis; D022121:Cholera Vaccines / Q000276:immunology* / Q000633:toxicity; D006801:Humans; D007117:Immunization, Secondary; D008875:Middle Aged; D014613:Vaccines, Attenuated / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D022121:Cholera Vaccines; D014613:Vaccines, Attenuated