Muscle lactate dehydrogenase activity is decreased in murine motor neuron disease.
Lactic dehydrogenase (LDH) activity was examined in affected skeletal muscles of the wobbler mouse, a murine model in which denervation follows degeneration of spinal cord motoneurons. Average biceps brachii LDH activity was reduced at 7 and 15 but not at 3 postnatal weeks. These results demonstrate a progressive alteration in muscle energy metabolism in a natural model of motor neuron disease.
Mandler
R N
RN
Department of Neurology, University of New Mexico School of Medicine, Albuquerque 87131.
Baca
J M
JM
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D005260:Female; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008297:Male; D051379:Mice; D008818:Mice, Neurologic Mutants; D009046:Motor Neurons; D024510:Muscle Development; D009132:Muscles / Q000201:enzymology*; D009468:Neuromuscular Diseases / Q000201:enzymology*; D012016:Reference Values
D007770:L-Lactate Dehydrogenase