Promoting effects of potassium dibasic phosphate on early-stage renal carcinogenesis in unilaterally nephrectomized rats treated with N-ethyl-N-hydroxyethylnitrosamine.
The effects of potassium dibasic phosphate (PDP), potassium aluminum sulfate (PAS) and copper sulfate (CS) on early-stage renal carcinogenesis were investigated in unilaterally nephrectomized male Wistar rats after N-ethyl-N-hydroxyethylnitrosamine (EHEN) administration. After feeding 1,000 ppm EHEN, or basal diet for 2 weeks and removal of the left kidney at week 3, male Wistar rats were divided into 8 groups of 20 rats each. These groups received the following dietary treatments: 50,000 ppm PDP, 50,000 ppm PAS, 5,000 ppm CS or basal diet, respectively, for 18 weeks from weeks 3 to 20. The average numbers of adenomatous hyperplasias counted as preneoplastic lesions in the EHEN with 50,000 ppm PDP group were significantly higher than in the EHEN alone group or the EHEN followed by 50,000 ppm PAS or 5,000 ppm CS group. The treatment with 50,000 ppm PDP induced renal calcification and promoted the development of preneoplastic lesions in unilaterally nephrectomized rats treated with EHEN, but that with 50,000 ppm PAS or 5,000 ppm CS did not.
Hiasa
Y
Y
Second Department of Pathology, Nara Medical University.
Konishi
N
N
Nakaoka
S
S
Nakamura
T
T
Nishii
K
K
Ohshima
M
M
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001973:Bromodeoxyuridine / Q000378:metabolism; D002273:Carcinogens; D002292:Carcinoma, Renal Cell / Q000097:blood / Q000139:chemically induced*; D003300:Copper; D019327:Copper Sulfate; D004052:Diethylnitrosamine / Q000031:analogs & derivatives; D004357:Drug Synergism; D004573:Electrolytes / Q000097:blood; D006965:Hyperplasia / Q000139:chemically induced; D007668:Kidney / Q000033:anatomy & histology / Q000187:drug effects* / Q000473:pathology; D007680:Kidney Neoplasms / Q000097:blood / Q000139:chemically induced*; D008297:Male; D009392:Nephrectomy; D009929:Organ Size / Q000187:drug effects; D010710:Phosphates; D011188:Potassium; D017680:Potassium Compounds; D051381:Rats; D011919:Rats, Inbred Strains
D002273:Carcinogens; D004573:Electrolytes; D010710:Phosphates; D017680:Potassium Compounds; C023845:N-ethyl-N-hydroxyethylnitrosamine; D004052:Diethylnitrosamine; D003300:Copper; C013216:potassium phosphate; D001973:Bromodeoxyuridine; D019327:Copper Sulfate; D011188:Potassium