Synthesis and biological activities of cyclopropenone antibiotic penitricin and congeners.
A number of derivatives of the cyclopropenone antibiotic penitricin have been synthesized by the reaction of metalated cyclopropenone acetals with electrophiles. Studies on the antimicrobial structure-activity relationships indicated that the penitricin skeleton, hydroxymethylcyclopropenone, is indispensable for antimicrobial activity. These compounds were also found to display cytotoxic activity.
Tokuyama
H
H
Department of Chemistry, Tokyo Institute of Technology, Japan.
Isaka
M
M
Nakamura
E
E
Ando
R
R
Morinaka
Y
Y
D001419:Bacteria / Q000187:drug effects; D003521:Cyclopropanes / Q000138:chemical synthesis / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008722:Methods; D008826:Microbial Sensitivity Tests
D003521:Cyclopropanes; C042542:penitricin