Monitoring of antibodies against human immunodeficiency virus type 1 p25 core protein as prognostic marker.
Anti-p25 antibodies were evaluated by cross-sectional analysis of sera from 130 human immunodeficiency virus type 1-infected patients and in a longitudinal study of 56 patients by retrospective analysis of sequentially collected sera. High and stable antibody levels were found in Centers for Disease Control stage II or III patients, 78% of whom had levels greater than 10 arbitrary units/mL. Patients with AIDS-related complex displayed heterogeneous levels. Patients with AIDS had the lowest values: less than or equal to 10 units/mL in 96% of cases. In patients whose CD4+ cell counts eventually fell below 200/mm3 or who developed AIDS (or both), antibodies were initially less than 40 units/mL and/or they declined with a rate greater than 1 log unit/5 years, beginning at least 4 years before the index symptom. Because the only point at which CD4+ cell counts significantly differed between progressors and nonprogressors was 1 year before the disease, both initial anti-p25 values and antibody decline seemed to be better long-term prognostic markers than CD4+ cell counts.
Fenouillet
E
E
Laboratoire de Biologie et Génétique des Pathologies Immunitaires, Centre National de la Recherche Scientifique Unité de Recherche Associée 1463, Paris, France.
Blanes
N
N
Coutellier
A
A
Demarquest
J
J
Rozenbaum
W
W
Gluckman
J C
JC
D000328:Adult; D015415:Biomarkers; D015153:Blotting, Western; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015683:Gene Products, gag / Q000276:immunology*; D015483:HIV Antibodies / Q000097:blood* / Q000276:immunology; D015658:HIV Infections / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011863:Radioimmunoassay; D054301:gag Gene Products, Human Immunodeficiency Virus
D015415:Biomarkers; D015683:Gene Products, gag; D015483:HIV Antibodies; C059827:HIV gag protein p25; D054301:gag Gene Products, Human Immunodeficiency Virus