title: Ischemia-induced irreversible deficit of memory function in gerbils.
abstract: Ischemia for 5 min temporarily increased locomotor activity in gerbils after 1 and 3 days. Temporary increases were also noted within 7 and 5 days after 20-min ischemia and repeated ischemia (three 2-min ischemia at 1-h intervals), respectively. In a passive avoidance task, gerbils were trained 2 or 14 days before the occlusion and then tested 1 day after it. Shortened step-through latency was observed in the retention test 3 days after 5-min ischemia, but not after 15 days (reversible deficit). In contrast, following 20-min ischemia, the step-through latency was significantly lower after 3 days and also after 15 days (irreversible deficit). Working memory was also tested with gerbils trained for an 8-arm radial maze task. A significantly higher working error was observed 1 day after 5-min ischemia but not after 5 days (reversible deficit). However, ischemia for 20-min and repeated ischemia led to markedly increase working error 1 day after the occlusion, with significant increases even after 14 and 28 days (irreversible deficit). In addition, while 5-min ischemia occurred the neuronal death in the hippocampal CA1 subfield, 20-min ischemia produced it not only in the CA1 subfield but also in the CA2-4 subfield and dorsal striatum. These results indicated that 5-min ischemia led to a reversible memory deficit, while 20-min and repeated ischemia produced an irreversible deficit.
authors.affiliation: Division of Pharmacology, Shionogi and Co., Ltd., Osaka, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Katoh
authors.forename: C
authors.initials: C
authors.lastname: Ishibashi
authors.forename: T
authors.initials: T
authors.lastname: Shiomi
authors.forename: Y
authors.initials: Y
authors.lastname: Takahara
authors.forename: M
authors.initials: M
authors.lastname: Eigyo
mesh_terms: D000647:Amnesia / Q000209:etiology*; D000818:Animals; D001157:Arterial Occlusive Diseases / Q000150:complications; D001362:Avoidance Learning / Q000502:physiology*; D002340:Carotid Artery Diseases / Q000150:complications; D016923:Cell Death / Q000502:physiology; D003342:Corpus Striatum / Q000473:pathology; D005849:Gerbillinae; D006624:Hippocampus / Q000473:pathology; D002546:Ischemic Attack, Transient / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D013997:Time Factors