Septal polydipsia in rats is a primary polydipsia not mediated by dopamine.
Bilateral lesions of nucleus septal lateralis resulted in a sustained and significant increase in water intake, without any change in food intake. Intracerebral injection of dopamine (DA) or of spiperone (a central D2-receptor antagonist) did not elicit any change in water or food intake. The polydipsia resulting from septal lesions is thus a primary polydipsia, which is independent of food intake, and is not mediated by neurotransmitter dopamine.
Pal
G K
GK
Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry.
Thombre
D P
DP
D000818:Animals; D004298:Dopamine / Q000494:pharmacology*; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012686:Septal Nuclei / Q000187:drug effects / Q000502:physiology*; D013134:Spiperone / Q000494:pharmacology*; D013894:Thirst / Q000502:physiology*
D013134:Spiperone; D004298:Dopamine