title: [Clinical study on meropenem in pediatric field].
abstract: We studied clinical effects of meropenem (MEPM, SM-7338), a newly developed parenteral carbapenem beta-lactam drug, and following results were obtained. The patients were administered with 16-20 mg/kg of MEPM every 8 hours using 1 hour drip infusion. 1. Clinical effects of MEPM were studied in 10 children with various infectious diseases: 1 with acute bronchitis, and 2 each with acute tonsillitis, acute bronchopneumonia, acute pneumonia, acute urinary infection, and 1 with pertussis pneumonia. The case of pertussis pneumonia later developed bronchiolitis obliterans, hence a steroid and gamma-globulin were used. This case was excluded from the clinical evaluation. The efficacy rate was 100% (9/9), and the bacteriological eradication rate was 100% (6/6). 2. No side effects were noted. Clinical laboratory test values were investigated in 10 patients. There was a case of abnormal laboratory test findings with mild elevations of liver functions such as GOT, GPT, and gamma-GTP. These abnormalities disappeared in 1 week after the end of therapy.
authors.affiliation: Department of Infectious Disease, Tokyo Metropolitan Komagome Hospital.
authors.forename: K
authors.initials: K
authors.lastname: Hachimori
authors.forename: M
authors.initials: M
authors.lastname: Noda
mesh_terms: D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007223:Infant; D008099:Liver / Q000187:drug effects; D008111:Liver Function Tests; D008297:Male; D000077731:Meropenem; D013845:Thienamycins / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D013845:Thienamycins; D000077731:Meropenem