The hypertrophied myocardium and coronary disease. Structural changes in patients submitted to aortocoronary bypass surgery.
Seventeen patients with coronary disease submitted to myocardial revascularization were studied. Ten patients had a hypertrophied ventricle, and 7 had normal ventricular mass. Myocardial biopsies were obtained before ischemia and at the time of reperfusion and were assessed for: volume fraction of fibrous tissue, myocyte diameter, morphometric mitochondrial studies and ultrastructural changes. The volume fraction of fibrous tissue in patients with hypertrophied ventricle was 1.9 +/- 0.04, and in patients with normal ventricular mass was 0.9 +/- 0.01 (p less than 0.05). The diameter of the myocyte was 23 +/- 0.3 microns and 18 +/- 1.2 microns for patients with hypertrophied and normal ventricular mass, respectively (p less than 0.01). The value of volumetric density for pre-ischemia samples in patients with a hypertrophied ventricle was 23 +/- 2.2 and in patients with normal ventricular mass was 35 +/- 2.7 (p less than 0.02). Grades 3 and 4 of damaged mitochondria were significantly increased in reperfusion samples from patients with a hypertrophied ventricle compared to pre-ischemia samples. Collagen growth was increased in hypertrophied hearts which were also more sensitive to the ischemia/reperfusion mechanism.
Ferreira
R
R
Department of Cardiovascular Surgery, ECAVI, Policlinico Bancario, Buenos Aires, Argentina.
Milei
J
J
Forcada
P
P
Beigelman
R
R
Molteni
L
L
Cutrin
J C
JC
D001706:Biopsy; D002312:Cardiomyopathy, Hypertrophic / Q000473:pathology*; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000473:pathology* / Q000601:surgery; D003720:Densitometry; D005355:Fibrosis; D006801:Humans; D008875:Middle Aged; D008929:Mitochondria, Heart / Q000648:ultrastructure; D009206:Myocardium / Q000473:pathology* / Q000648:ultrastructure; D012518:Sarcomeres / Q000648:ultrastructure