[Value of a provocation test with diprafenone in patients with bifascicular block].
The significance of provocative tests in patients with bifascicular block is not established. We studied 14 patients with bifascicular block, syncope and documented episodes of high degree AV-block. 1.5 mg/kg Diprafenon was given after a period of at last 12 hours 1:1 AV-conduction. Electrophysiologic evaluation was performed before and after diprafenon. AV-block III could be provoked in 1 of 14 patients with Diprafenon. Therefore a total AV block occurred in 7% of patients. The low sensitivity of provocative test with Diprafenon even in patients with documented high degree AV-block prevents its application in clinical practice.
Hief
C
C
Ludwig-Boltzmann-Institut für Arrhythmieforschung, 3. Medizinische Abteilung, Wilhelminenspital, Wien.
Frohner
K
K
Podczeck
A
A
Kaltenbrunner
W
W
Nürnberg
M
M
Steinbach
K
K
D000368:Aged; D000369:Aged, 80 and over; D000889:Anti-Arrhythmia Agents; D001283:Atrioventricular Node / Q000187:drug effects / Q000503:physiopathology; D002304:Cardiac Pacing, Artificial; D004562:Electrocardiography / Q000187:drug effects*; D005260:Female; D006327:Heart Block / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011405:Propafenone / Q000031:analogs & derivatives*
D000889:Anti-Arrhythmia Agents; C047546:diprafenone; D011405:Propafenone
Stellenwert eines Provokationstestes mit Diprafenon bei Patienten mit bifaszikulärem Block.