title: Subcellular localization of two neurotropic drugs in three varieties of central nervous system cells by secondary ion mass spectroscopy (SIMS) microscopy.
abstract: The intracellular localization of two neurotropic drugs, flunitrazepam (benzodiazepine) and triflupromazine (phenothiazine), was studied by secondary ion mass spectrometry microscopy (SIMS) in three varieties of cells. The images of the intracellular distributions of the two drugs are easily obtained by selecting the fluorine atom of the molecules. These images show that the drug from the benzodiazepine group is mainly located in the nuclei, whereas the phenothiazine is exclusively located inside the cytoplasm.
authors.affiliation: SC 27 INSERM, Medical Faculty, Créteil, France.
authors.forename: L L
authors.initials: LL
authors.lastname: Zhang
authors.forename: M
authors.initials: M
authors.lastname: Tardy
authors.forename: J P
authors.initials: JP
authors.lastname: Berry
authors.forename: F
authors.initials: F
authors.lastname: Escaig
authors.forename: P
authors.initials: P
authors.lastname: Galle
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D002490:Central Nervous System / Q000737:chemistry*; D005445:Flunitrazepam / Q000032:analysis*; D013058:Mass Spectrometry / Q000379:methods*; D051379:Mice; D008853:Microscopy / Q000379:methods*; D014273:Triflupromazine / Q000032:analysis*
chemical_list: D005445:Flunitrazepam; D014273:Triflupromazine