Beneficial effect of low-glycemic index diet in overweight NIDDM subjects.
OBJECTIVE
To determine whether low-glycemic index (GI) diets have clinical utility in overweight patients with non-insulin-dependent diabetes mellitus (NIDDM).


METHODS
Six patients with NIDDM were studied on both high- and low-GI diets of 6-wk duration with metabolic diets with a randomized crossover design. Both diets were of similar composition (57% carbohydrate, 23% fat, and 34 g/day dietary fiber), but the low-GI diet had a GI of 58 compared with 86 for the high-GI diet.


RESULTS
Small and similar amounts of weight were lost on both diets: 2.5 kg on high-GI diet and 1.8 kg on low-GI diet. On the low-GI diet, the mean level of serum fructosamine, as an index of overall blood glucose control, was lower than on the high-GI diet by 8% (P less than 0.05), and total serum cholesterol was lower by 7% (P less than 0.01).


CONCLUSIONS
In overweight patients with NIDDM, reducing diet GI improves overall blood glucose and lipid control.
Wolever
T M
TM
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada.
Jenkins
D J
DJ
Vuksan
V
V
Jenkins
A L
AL
Wong
G S
GS
Josse
R G
RG
D001786:Blood Glucose / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003920:Diabetes Mellitus / Q000178:diet therapy* / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy* / Q000503:physiopathology; D003927:Diet, Diabetic; D004038:Diet, Reducing; D004040:Dietary Carbohydrates; D005260:Female; D019270:Fructosamine; D006595:Hexosamines / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity; D014280:Triglycerides / Q000097:blood; D015431:Weight Loss
D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004040:Dietary Carbohydrates; D006595:Hexosamines; D014280:Triglycerides; D019270:Fructosamine; D002784:Cholesterol