title: A reappraisal of the measurement of glomerular filtration rate in pre-term infants.
abstract: Thirty-seven single-injection polyfructosan-S (PF-S, Inutest) and 98 continuous-infusion PF-S/creatinine clearance studies were performed in 39 sick very low birth weight infants. The single-injection clearance method for measuring glomerular filtration rate has been shown to be a reliable technique if sampling is continued for 8 h or more and the PF-S (Inutest) assay is sensitive, accurate and precise. The continuous-infusion clearance method is also valid if the infusion is continued for more than 24 h and preceded by a loading dose in the form of a double-rate infusion for 8 h. Creatinine clearance is usually less than PF-S clearance, the mean ratio being 0.91, suggesting that there is some creatinine reabsorption in the renal tubule in sick very low birth weight infants.
authors.affiliation: Department of Child Health, Bristol University, UK.
authors.forename: B H
authors.initials: BH
authors.lastname: Wilkins
mesh_terms: D003404:Creatinine / Q000097:blood / Q000652:urine; D005630:Fructans / Q000493:pharmacokinetics*; D005919:Glomerular Filtration Rate; D006801:Humans; D007230:Infant, Low Birth Weight / Q000378:metabolism*; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000378:metabolism*; D007444:Inulin / Q000493:pharmacokinetics; D007678:Kidney Glomerulus / Q000378:metabolism; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D005630:Fructans; C002938:polyfructosan; D007444:Inulin; D003404:Creatinine