title: Evaluation of an atrophic rhinitis vaccine under controlled conditions.
abstract: A vaccine containing inactivated cultures of Bordetella bronchiseptica, toxigenic Pasteurella multocida type D and dermonecrotic P multocida type D toxoid in an oil-in-water adjuvant was given to seven sows, with seven others acting as controls. Half the piglets in each litter were exposed intranasally when four days old to B bronchiseptica and when eight days old to toxigenic P multocida type D. There was considerably less sneezing in the litters of the vaccinated sows and when the piglets were 10 weeks old, only 18 per cent had deformed snouts compared with 74 per cent in the litters of the control sows. The average liveweight gain of the piglets born to vaccinated sows was significantly better (P less than 0.05) between two and 10 weeks of age than that of the piglets born to unvaccinated sows, although there were no significant lower respiratory tract lesions in either group. The conchal atrophy scores were significantly lower (P less than 0.001) in the piglets from the vaccinated sows and were negatively correlated (r = -0.37) with increasing liveweight gain. In the liters of the vaccinated sows, P multocida was not isolated from the nasal passages of the in-contact piglets and from only 7 per cent of those deliberately exposed compared with 65 per cent and 79 per cent, respectively, in the litters of the control sows. P multocida was isolated post mortem from the tonsils of 23 per cent of the piglets of vaccinated sows and from 87 per cent of those from unvaccinated sows.
authors.affiliation: Gezondheidsdienst voor Dieren in Zuid-Nederland, Boxtel, The Netherlands.
authors.forename: M T
authors.initials: MT
authors.lastname: Voets
authors.forename: C H
authors.initials: CH
authors.lastname: Klaassen
authors.forename: P
authors.initials: P
authors.lastname: Charlier
authors.forename: A
authors.initials: A
authors.lastname: Wiseman
authors.forename: J
authors.initials: J
authors.lastname: Descamps
mesh_terms: D000818:Animals; D001284:Atrophy; D001428:Bacterial Vaccines; D001885:Bordetella Infections / Q000517:prevention & control / Q000662:veterinary; D016950:Bordetella bronchiseptica / Q000276:immunology*; D005260:Female; D010326:Pasteurella Infections / Q000517:prevention & control / Q000662:veterinary; D016979:Pasteurella multocida / Q000276:immunology*; D012222:Rhinitis, Atrophic / Q000517:prevention & control / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000517:prevention & control*; D014420:Turbinates / Q000473:pathology; D014611:Vaccination / Q000662:veterinary; D014613:Vaccines, Attenuated; D015430:Weight Gain
chemical_list: D001428:Bacterial Vaccines; D014613:Vaccines, Attenuated