title: [Fulminant hepatitis after the inhalation of dichloropropanols].
abstract: A fatal case of acute fulminant hepatitis following exposure to dichloropropanols is reported. A 59-year-old male worker in a chemical plant developed general malaise, nausea and vomiting several hours after cleaning a tank that had contained dichloropropanols. He had no previous history of hepatic dysfunction. On admission, hepatomegaly was prominent. Because of highly elevated levels of GOT and GPT in the serum, reduced prothrombin time and a lowered consciousness level, a diagnosis of fulminant hepatitis was made. Significant decreases of leukocytes and platelets were also observed. Serum creatinine and BUN were slightly elevated. Although plasma exchanges were conducted on the third and fourth day, the liver functions continued to deteriorate. The patient died on the fifth day. Because dichloropropanols could be detected in the blood specimens obtained at the time of admission, we considered that fulminant hepatitis in this case was attributed to dichloropropanols exposure. To our knowledge, this is the first case of fulminant hepatitis after dichloropropanols-exposure.
authors.affiliation: Department of Internal Medicine, Kansai Rosai Hospital, Amagasaki, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Iwasa
authors.forename: T
authors.initials: T
authors.lastname: Abe
authors.forename: K
authors.initials: K
authors.lastname: Hiramatsu
authors.forename: S
authors.initials: S
authors.lastname: Kubori
authors.forename: N
authors.initials: N
authors.lastname: Inoue
authors.forename: K
authors.initials: K
authors.lastname: Fujishiro
authors.forename: M
authors.initials: M
authors.lastname: Koga
mesh_terms: D000280:Administration, Inhalation; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002728:Chlorohydrins / Q000506:poisoning*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced*; D016273:Occupational Exposure
chemical_list: D002728:Chlorohydrins