title: Urinary excretion of IGF-I and growth hormone in children with IDDM.
abstract: OBJECTIVE
  To compare the urinary output of insulinlike growth factor I (IGF-I) and growth hormone (GH) in prepubertal and pubertal children with insulin-dependent diabetes mellitus (IDDM) versus nondiabetic subjects and to analyze the relationship between the urinary excretion of these peptides and degree of metabolic control.
  
  
  METHODS
  Group 1 included 30 IDDM patients who had had diabetes for 4.9 +/- 0.7 yr and had normal renal function (mean age 11.6 +/- 0.9 yr); group 2 consisted of 31 control subjects (mean age 9.2 +/- 0.6 yr). Sensitive radioimmunoassays were used to measure IGF-I and GH in urine aliquots from 12-h timed overnight collections that had been dialyzed, concentrated 50-fold, and lyophilized.
  
  
  RESULTS
  Significantly lower IGF-I and GH outputs per kilogram body weight per 12 h were observed in IDDM subjects compared with control subjects. When data were expressed per kilogram of body weight, no difference was observed between the urinary output of IGF-I and GH between prepubertal and pubertal subjects within group 1 or group 2. The prepubertal children had significantly lower HbA1 than the pubertal population; however, no correlation was found between urinary output of IGF-I or GH and HbA1. A positive correlation was observed between urinary IGF-I and GH (r = 0.85, P less than .001).
  
  
  CONCLUSIONS
  Patients with long-standing IDDM excrete significantly lower urinary levels of IGF-I and GH compared with normal subjects. Serial measurements of these peptides from onset of IDDM are needed to define whether the changes observed are present at diagnosis or are secondary to duration of disease.
authors.affiliation: Department of Pediatrics, Children's Hospital of Buffalo, NY 14222.
authors.forename: T
authors.initials: T
authors.lastname: Quattrin
authors.forename: C H
authors.initials: CH
authors.lastname: Albini
authors.forename: E O
authors.initials: EO
authors.lastname: Reiter
authors.forename: B J
authors.initials: BJ
authors.lastname: Mills
authors.forename: M H
authors.initials: MH
authors.lastname: MacGillivray
mesh_terms: D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000652:urine*; D005260:Female; D013006:Growth Hormone / Q000652:urine*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000652:urine*; D008297:Male; D011627:Puberty / Q000652:urine*; D011863:Radioimmunoassay; D012016:Reference Values
chemical_list: D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone