Penicillin derived C2-symmetric dimers as novel inhibitors of HIV-1 proteinase.
Humber
D C
DC
Department of Medicinal Chemistry II, Glaxo Group Research Limited, Greenford, Middlesex, United Kingdom.
Cammack
N
N
Coates
J A
JA
Cobley
K N
KN
Orr
D C
DC
Storer
R
R
Weingarten
G G
GG
Weir
M P
MP
D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D004149:Dioxoles / Q000494:pharmacology* / Q000627:therapeutic use; D017320:HIV Protease Inhibitors; D015497:HIV-1 / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D006801:Humans; D010406:Penicillins / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects; D014961:X-Ray Diffraction
D000998:Antiviral Agents; D004149:Dioxoles; D017320:HIV Protease Inhibitors; D010406:Penicillins; C076126:disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate