[Bone marrow transplantation in malignant diseases in childhood using reverse isolation technics: evaluation of results].
Between July 1985 and March 1990, 31 pediatric patients with neoplastic diseases underwent bone marrow transplantation (22 allogenic and 9 autologous). Routine reverse isolation techniques with sterilization of the gastrointestinal tract were used in all cases. Of these patients, 55% had fever and 32% had a documented infection. In allogenic bone marrow transplants, 23% developed graft-versus-host disease, grade I-IV. The incidence of infection and graft-versus-host disease compares favorably with other published reports from centers utilizing laminar air flow rooms during bone marrow transplantation. This suggest that standard reverse isolation techniques may be used without increasing the morbidity and mortality in these patients.
Otheo de Tejada
E
E
Servicio de Pediatría, Hospital Ramón y Cajal, Universidad de Alcalá de Henares, Madrid.
Maldonado Regalado
M S
MS
Muñoz Villa
A
A
Pérez de Oteyza
J
J
García Laraña
J
J
D000367:Age Factors; D001424:Bacterial Infections / Q000517:prevention & control; D016026:Bone Marrow Transplantation / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006084:Graft Rejection; D006087:Graft vs Host Reaction; D006801:Humans; D007938:Leukemia / Q000628:therapy*; D008297:Male; D009369:Neoplasms / Q000628:therapy*; D010356:Patient Isolation
Trasplante de médula ósea en enfermedades malignas en la edad pediátrica con aislamiento inverso convencional: valoración de resultados.