title: Flow-induced deformation from pressurized cavities in absorbing porous tissues.
abstract: The behaviour of a cavity during an injection of fluid into biological tissue is considered. High cavity pressure drives fluid into the neighbouring tissue where it is absorbed by capillaries and lymphatics. The tissue is modelled as a nonlinear deformable porous medium with the injected fluid absorbed by the tissue at a rate proportional to the local pressure. A model with a spherical cavity in an infinite medium is used to find the pressure and displacement of the tissue as a function of time and radial distance. Analytical and numerical solutions for a step change in cavity pressure show that the flow induces a radial compression in the medium together with an annular expansion, the net result being an overall expansion of the medium. Thus any flow induced deformation of the material will aid in the absorption of fluid.
authors.affiliation: Mathematics Department, University College, University of New South Wales, Canberra, Australia.
authors.forename: S I
authors.initials: SI
authors.lastname: Barry
authors.forename: G K
authors.initials: GK
authors.lastname: Aldis
mesh_terms: D000042:Absorption; D000818:Animals; D001825:Body Fluid Compartments / Q000502:physiology*; D006801:Humans; D007267:Injections; D008433:Mathematics; D008954:Models, Biological; D011312:Pressure