title: Haplotype analysis and polymorphic frequency data at two factor IX loci (F9-192 and F9-Hha1) in a Chinese population.
abstract: Gene frequencies and haplotypes for two factor IX markers, F9-192 and F9-Hha1, were determined in a Chinese population. The frequencies for F9-192 are 0.86 for A and 0.14 for G. For F9-Hha1, the gene frequencies are 0.69 for - and 0.31 for +. Haplotype analysis revealed that the two polymorphic sites are in linkage equilibrium and, thus, are useful markers for genetic counseling of Asian families in which hemophilia B exists.
authors.affiliation: Department of Pediatrics, University of Washington, Seattle 98195.
authors.forename: S H
authors.initials: SH
authors.lastname: Chen
authors.forename: N S
authors.initials: NS
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Schoof
authors.forename: C R
authors.initials: CR
authors.lastname: Scott
mesh_terms: D000483:Alleles; D001483:Base Sequence; D002681:China / Q000208:ethnology; D002874:Chromosome Mapping; D005164:Factor IX / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D005164:Factor IX