IgA immunoassay for the diagnosis of bancroftian filariasis.
In some parasitic infection such as toxoplasmosis, specific IgA is a highly reliable marker of active infection. In bancroftian filariasis, only 10 of 20 (50%) and 3 of 20 (15%) of the microfilaremic patients were positive for IgA anti-Brugia malayi using respectively indirect ELISA and immunocapture ELISA tests. As regard to these low sensitivities, the detection of specific IgA is unlikely to be a useful test for the diagnosis of active Wuchereria bancrofti infection.
Chanteau
S
S
Institut Territorial de Recherches Médicales Louis Malardé, Papeete Tahiti, French Polynesia.
Cartel
J L
JL
Martin
P M
PM
D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood*; D004605:Elephantiasis, Filarial / Q000175:diagnosis*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D012680:Sensitivity and Specificity; D014958:Wuchereria bancrofti / Q000276:immunology*
D000909:Antibodies, Helminth; D007070:Immunoglobulin A