title: [Effect of chemotherapy on the antibody response to A60 antigen].
abstract: BACKGROUND
  Study of the serologic response in two groups of patients with pulmonary tuberculosis: with and without treatment.
  
  
  METHODS
  Antibodies (type IgG) against the A60 antigen were studied in 103 patients with pulmonary tuberculosis: 46 without specific treatment and 57 after the application of the chemotherapy.
  
  
  RESULTS
  81.6% of the patients showed antibodies against the A60 antigen and 60.2% were strongly positive; 32.6% and 41.3% of the patients without treatment were negative and strongly positive respectively. In the patients with treatment this results were 7% and 75.4%. The differences found between both groups were statistically significant (p less than 0.001).
  
  
  CONCLUSIONS
  It is concluded that the application of the specific treatment modify in a high percentage the response of antibody against A60 antigen and which reduced the false negatives response, this fact could condition the clinic utility of the test.
authors.affiliation: Servicio de Microbiología, Hospital La Paz, Madrid.
authors.forename: M C
authors.initials: MC
authors.lastname: Ladrón de Guevara
authors.forename: M
authors.initials: M
authors.lastname: Beltrán
authors.forename: A
authors.initials: A
authors.lastname: Gutiérrez
authors.forename: J V
authors.initials: JV
authors.lastname: Saz
mesh_terms: D000907:Antibodies, Bacterial / Q000096:biosynthesis* / Q000097:blood / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology*; D000995:Antitubercular Agents / Q000494:pharmacology*; D004797:Enzyme-Linked Immunosorbent Assay; D005188:False Negative Reactions; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis* / Q000097:blood / Q000276:immunology; D009163:Mycobacterium bovis / Q000276:immunology*; D013268:Stimulation, Chemical; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D000995:Antitubercular Agents; D007074:Immunoglobulin G; C055539:mycobacterial A60 antigen
vernacular_title: Influencia de la quimioterapia en la respuesta de anticuerpos frente al antígeno A60.