Urethral pressure response to alpha-adrenergic agonist and antagonist drugs in anesthetized healthy male cats.
Urethral smooth muscle tone in response to treatment with phenylephrine, a selective alpha 1-adrenergic receptor agonist, and prazosin a selective alpha 1-adrenergic receptor antagonist, was evaluated in 12 anesthetized healthy adult sexually intact male cats. Intravenous administration of prazosin (20 to 30 micrograms/kg of body weight) decreased the average preprostatic and prostatic intraurethral pressure, compared with baseline and postphenylephrine (20 to 30 micrograms/kg) administration, values. Neither prazosin nor phenylephrine administration had an effect on functional urethral length. Results have implications for the pharmacologic management of lower urinary tract disorders in male cats.
Frenier
S L
SL
Department of Veterinary Clinical Medicine and Surgery, College of Veterinary Medicine, Washington State University, Pullman 99164.
Knowlen
G G
GG
Speth
R C
RC
Moore
M P
MP
D000704:Analysis of Variance; D000768:Anesthesia, General / Q000662:veterinary; D000818:Animals; D002415:Cats / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D010656:Phenylephrine / Q000008:administration & dosage / Q000494:pharmacology*; D011224:Prazosin / Q000008:administration & dosage / Q000494:pharmacology*; D011312:Pressure; D014521:Urethra / Q000187:drug effects* / Q000502:physiology
D010656:Phenylephrine; D011224:Prazosin