Activation of neutrophils by granulocyte-macrophage colony-stimulating factor.
A hypothetical pathway of GM-CSF-induced signaling in human neutrophils is presented in Figure 4. The earliest postreceptor events leading to activation of cellular kinases and phosphorylation of c-raf on tyrosine and serine remain a mystery. It is conceivable that downstream events such as the production of LTB4 and PAF as well as other autocrine or paracrine activators of neutrophil-activation function may be involved in neutrophil activation and priming, or they may be downstream events irrelevant in the signaling cascade. The association of GM-CSF signaling and G-proteins, PLD, c-raf, tyrosine kinases, and the Na+/H+ antiport remain poorly understood.
DiPersio
J F
JF
University of Rochester School of Medicine and Dentistry, New York.
Abboud
C N
CN
D000199:Actins / Q000378:metabolism; D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology* / Q000502:physiology; D006801:Humans; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D010972:Platelet Activating Factor / Q000096:biosynthesis; D015398:Signal Transduction
D000199:Actins; D001095:Arachidonic Acids; D010972:Platelet Activating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor