[Participation of cholecystokinin and pentagastrin in the regulation of the liver blood supply and oxygen consumption].
Cholecystokinin and pentagastrin cause predominantly the dilatation of mesenterial, intrahepatic arterial and portal vessels. The short-term amplitude-expressed changes in the vascular blood flow followed by less intensive long-term ones are observed. The amplitude of short-term reactions in these vascular regions is different and depends on the place of hormone injections. Cholecystokinin and pentagastrin in the same series of experiments decrease and increase the oxygen consumption by the liver depending on its functional state. It is supposed that correction of the oxygen supply of hepatocytes by the action of pentagastrin is realized due to changes in the blood flow in the liver artery, and under the cholecystokinin effect it is made by the change of the oxygen extraction.
Kovalenko
S O
SO
Ianchuk
P I
PI
D000818:Animals; D002766:Cholecystokinin / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D006499:Hepatic Artery / Q000187:drug effects* / Q000502:physiology; D007275:Injections, Intravenous; D008099:Liver / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism; D008102:Liver Circulation / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008642:Mesenteric Veins / Q000187:drug effects* / Q000502:physiology; D008955:Models, Cardiovascular; D010101:Oxygen Consumption / Q000187:drug effects* / Q000502:physiology; D010418:Pentagastrin / Q000008:administration & dosage / Q000494:pharmacology*; D011169:Portal Vein / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors; D014665:Vasodilator Agents
D014665:Vasodilator Agents; D002766:Cholecystokinin; D010418:Pentagastrin
Uchast' kholetsystokininu i pentahastrynu v reguliatsiï krovopostachannia pechinki ta spozhivannia neiu kysniu.