title: [Changes in the heart rhythm and slow-release beta-2 agonist therapy (peroral) in asthmatic patients. A Holter study].
abstract: Slow-release formulations of salbutamol, used in asthmatic patients, may have few effects on cardiac rhythm. This study was designed to compare incidence and type of cardiac arrhythmias in a group of ten patients with stable bronchial asthma before and after 6 weeks treatment with a slow-release formulation of salbutamol. After a baseline spirometric and electrocardiographic evaluation, patients received placebo for a two-weeks period. At the end of this period patients repeated spirometry and carried out a 24-hour-ambulatory-E-Holter-monitoring. Subsequently, patients received for 6 weeks a treatment with a slow-release formulation of oral salbutamol. At the end of this period patients repeated spirometry, a 24-hour-ambulatory-EG-Holter-monitoring and potassium serum levels were controlled. We concluded from our study that, in patients with moderate bronchial asthma the treatment with an oral formulation of slow-release salbutamol may carry out a significant and durable bronchodilator effect, without causing important cardiac arrhythmias.
authors.affiliation: Cattedra di Medicina interna I, UOP Scienze mediche, Università, Brescia.
authors.forename: M
authors.initials: M
authors.lastname: Malerba
authors.forename: A
authors.initials: A
authors.lastname: Politi
authors.forename: B
authors.initials: B
authors.lastname: Filippi
authors.forename: U
authors.initials: U
authors.lastname: Zambruni
authors.forename: V
authors.initials: V
authors.lastname: Grassi
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000420:Albuterol / Q000008:administration & dosage* / Q000009:adverse effects; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000453:epidemiology; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D003692:Delayed-Action Preparations; D015716:Electrocardiography, Ambulatory / Q000187:drug effects*; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012129:Respiratory Function Tests
chemical_list: D003692:Delayed-Action Preparations; D000420:Albuterol
vernacular_title: Alterazioni del ritmo cardiaco e terapia beta-2-agonista a lento rilascio (per via orale) in pazienti asmatici. Studio Holter.