Effect of cadmium and/or selenium on liver mitochondria and rough endoplasmic reticulum in the rat.
This study was conducted to investigate the effect of cadmium (Cd) and/or selenium (Se) on hepatic mitochondria and rough endoplasmic reticulum (RER). Male Sprague Dawley derived rats (150-200 g) received sodium acetate (NaAc; 1.23 mg/kg), Cd (0.84 mg/kg), and/or Se (1.6 mg/kg) intraperitoneally. Livers were perfused with 2% glutaraldehyde at 48 h, 72 h, or 96 h after treatment and prepared for electronmicroscopy. Results indicate that Cd and/or Se are capable of inflicting mitochondrial and RER structural changes, and the damage by Cd alone is more severe than Se alone or with Cd.
Early
J L
JL
Florida Agricultural & Mechanical University, College of Pharmacy and Pharmaceutical Sciences, Tallahasee 32307.
Nonavinakere
V K
VK
Weaver
A
A
D000085:Acetates / Q000494:pharmacology; D019342:Acetic Acid; D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D004347:Drug Interactions; D004721:Endoplasmic Reticulum / Q000187:drug effects*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012643:Selenium / Q000494:pharmacology* / Q000633:toxicity; D013997:Time Factors
D000085:Acetates; D002104:Cadmium; D012643:Selenium; D019342:Acetic Acid