[Disorders of pulmonary hemodynamics in patients with diabetic nephroangiopathy and its correction with antioxidants].
Hemodynamic changes of lesser circulation were investigated in 108 patients with diabetic nephroangiopathy. They were also given vitamin E therapy (8 micrograms/kg of body mass) for 2 weeks to correct metabolic derangements and indices of pulmonary hemodynamics. Partial renal function was determined with 131I-hippuran and 99mTc-DTPA renoscintigraphy. Pulmonary hemodynamics was assessed with pulmonary scintigraphy (MAA 99mTc). The results have shown that vascular renal lesions in diabetes mellitus cause hypertension of lesser circulation and disorders in pulmonary microcirculation, and disorders of lipid metabolism and activation of lipid peroxidation (LPO) progress with augmentation of severity of disease. Vitamin E therapy improves pulmonary hemodynamics, lipid metabolism and LPO. Antioxidant correction was most effective at the initial stages of diabetic nephroangiopathy.
Dzhavad-zade
M D
MD
Selimkhanova
Kh Kh
KhKh
Kuliev
F A
FA
D000975:Antioxidants / Q000627:therapeutic use*; D003925:Diabetic Angiopathies / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007668:Kidney / Q000000981:diagnostic imaging; D050356:Lipid Metabolism; D015227:Lipid Peroxidation / Q000502:physiology; D008833:Microcirculation / Q000187:drug effects; D011652:Pulmonary Circulation; D011877:Radionuclide Imaging; D014810:Vitamin E / Q000627:therapeutic use*
D000975:Antioxidants; D014810:Vitamin E
Narusheniia legochnoĭ gemodinamiki u bol'nykh s diabeticheskoĭ nefroangiopatieĭ i ikh antioksidantnaia korrektsiia.