title: [Manometric changes induced by antireflux surgery (Nissen) and its relation to pH measurement and clinical findings. An analysis 6 months after the intervention].
abstract: We analyzed the preoperative ambulatory 24 hour ph-metric and manometric characteristics in a group of 20 patients treated surgically for gastroesophageal reflux (PGER) by Nissen fundoplication. At 6 months post-surgery they were reevaluated instrumentally (manometric and 24 hour ph-metry) and clinically. All ph-metric parameters of PGER (total reflux time, clearance, number of episodes, number of episodes greater than 5 minutes duration and duration of longest episode) were significantly improved (p less than 0.01-0.05) post-operatively (as globally as by position supine and upright) and this improvement was associated with resolution of symptoms in 19 (95%) patients. Of the manometric parameters evaluated (lower esophageal sphincter pressure--LESP--and length--LESL, peristaltic, triphasic, biphasic, absent and simultaneous waves and relaxation of LES) surgery only produced improvement in the lower esophageal sphincter pressure (LESP) and length (LESL) (p less than 0.001). We conclude that antireflux surgery (Nissen) by improving the pressure and length of the LES is capable of producing clinical and ph-metric remission in almost all (95%) of patients studied six months after.
authors.affiliation: Servicio de Cirugía General y Ap. Digestivo C, Hospital 12 de Octubre,Madrid.
authors.forename: R
authors.initials: R
authors.lastname: Gómez
authors.forename: J
authors.initials: J
authors.lastname: Seoane
authors.forename: D
authors.initials: D
authors.lastname: Moreno
authors.forename: B
authors.initials: B
authors.lastname: Cuenca
authors.forename: M
authors.initials: M
authors.lastname: Hidalgo
authors.forename: A
authors.initials: A
authors.lastname: García
authors.forename: J C
authors.initials: JC
authors.lastname: Palomo
authors.forename: M
authors.initials: M
authors.lastname: Marcello
authors.forename: E
authors.initials: E
authors.lastname: Moreno
mesh_terms: D000367:Age Factors; D002908:Chronic Disease; D002940:Circadian Rhythm; D004943:Esophagogastric Junction / Q000601:surgery; D004947:Esophagus / Q000503:physiopathology; D005500:Follow-Up Studies; D005748:Gastric Fundus / Q000601:surgery; D005764:Gastroesophageal Reflux / Q000453:epidemiology / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008365:Manometry; D012737:Sex Factors; D013997:Time Factors
vernacular_title: Modificaciones manométricas inducidas por la cirugía antirreflujo (Nissen) y su relación con los hallazgos pH-métricos y clínicos. Análisis a los 6 meses de la intervención.