title: An interrupter technique for measuring respiratory mechanics and the pressure generated by respiratory muscles during partial ventilatory support.
abstract: We evaluated the airway occlusion maneuver as a method to estimate respiratory resistance, respiratory elastance and the pressure generated by respiratory muscles in ICU patients breathing in the PSV mode. The airflow was interrupted at selected flows or volumes during inspiration by a computer-driven rapid occlusion pneumatic valve. The airway occlusion was maintained for 2 to 3 s. From the airway pressure tracing we obtained various measurements of pressure. We then computed the pressure generated by the patient's inspiratory muscles. The method was validated by two different approaches in two groups of patients: the Pes and the CMV protocols. We conclude that the airflow interruption method can be used to measure basic respiratory mechanical parameters in PSV patients. The method also offers an opportunity to evaluate Pmusc,aw and the respiratory work performed by the patient.
authors.affiliation: Institute of Anesthesia and Intensive Care, University of Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Pesenti
authors.forename: P
authors.initials: P
authors.lastname: Pelosi
authors.forename: G
authors.initials: G
authors.lastname: Foti
authors.forename: L
authors.initials: L
authors.lastname: D'Andrea
authors.forename: N
authors.initials: N
authors.lastname: Rossi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000403:Airway Resistance / Q000502:physiology; D004947:Esophagus / Q000502:physiology; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D011312:Pressure; D012121:Respiration, Artificial / Q000379:methods*; D015656:Respiratory Mechanics / Q000502:physiology*; D012132:Respiratory Muscles / Q000502:physiology*