Maintenance requirements of Escherichia coli ATCC 25922 in the presence of sub-inhibitory concentrations of various antibiotics.
Escherichia coli ATCC 25922 was grown in minimal medium M63, with glucose 0.1 gL as limiting energy substrate, in the presence of sub-inhibitory concentrations of netilmicin, habekacin, tobramycin, dibekacin, amikacin, kanamycin, amoxycillin, ampicillin, cephalothin, cefoxitin and nalidixic acid. Maintenance requirements were determined with a simple relationship derived from batch growth curves. The apparent relationship between maintenance requirements and antibiotic concentration is an exponential increase, log m(c) = log mo + k.c, where m is maintenance, c antibiotics concentration, mo maintenance without antibiotics, and k a constant. Values for k were found to be in the range 0.5-2.0 mg-1.L.
Lobry
J R
JR
Laboratoire de Biométrie, CNRS URA 243, Université Claude Bernard, Villeurbanne, France.
Carret
G
G
Flandrois
J P
JP
D000583:Amikacin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D003470:Culture Media; D004926:Escherichia coli / Q000187:drug effects* / Q000502:physiology; D007612:Kanamycin / Q000494:pharmacology; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D008954:Models, Biological
D000900:Anti-Bacterial Agents; D003470:Culture Media; D007612:Kanamycin; D000583:Amikacin