Human giardiasis: correlation of specific secretory IgA levels in duodenal fluid to the severity of disease and infestation by Giardia lamblia.
Giardia lamblia specific secretory immunoglobulin A (sIgA) levels in the duodenal fluid of adult giardiasis cases are reported for the first time. The sIgA levels in the study group were found to be significantly higher (p less than 0.01) than in the 20 age- and sex-matched controls comprising cases classified as non-ulcerative dyspepsia who did nor reveal any G. lamblia in their stools and the duodenal fluid. An inverse relationship between the clinical severity of giardiasis and the level of sIgA in the duodenal fluid was noted. Cases with a higher trophozoite load in duodenal aspirate tended to be associated with envanescent G. lamblia-specific antibodies.
Randhawa
V S
VS
Department of Microbiology, Maulana Azad Medical College, New Delhi, India.
Sharma
V K
VK
Baveja
U K
UK
Vij
J C
JC
Malhotra
V
V
D000328:Adult; D000818:Animals; D004386:Duodenum / Q000276:immunology / Q000469:parasitology*; D016829:Giardia lamblia / Q000276:immunology*; D005873:Giardiasis / Q000276:immunology* / Q000469:parasitology; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000378:metabolism*; D007419:Intestinal Secretions / Q000276:immunology / Q000469:parasitology*; D008875:Middle Aged
D007071:Immunoglobulin A, Secretory