Correlation of motor-evoked potential response to ischemic spinal cord damage.
The prevalence of morbidity is a major deterrent to the success of aortic aneurysm replacement operations. We have developed a model of spinal cord ischemia, based on the amplitude reduction of the motor-evoked potential, which produces approximately a 90% prevalence of paraplegia. Regional blood flow was studied with the use of radioactive microspheres, and results showed that there was a significant decrease in flow to the lumbar cord (85% reduction) during aortic occlusion, followed by a twofold to threefold hyperemia that persisted for 24 hours. Histopathologic examination of the cord revealed that the greater portion of microgliosis, spongiosis, and neuronal damage was confined to the gray matter of the cord, and its severity increased as one progressed caudally. The somatosensory-evoked potential disappeared before the motor-evoked potential L-2 signal in all dogs, with a mean disappearance time of 10.9 +/- 5.6 minutes, compared with 21 +/- 6.6 minutes for the motor-evoked potential. Both the sensory-evoked potential and the motor-evoked potential cord signal were present 24 hours later in all dogs tested. The peripheral nerve motor-evoked potential disappeared within 1 minute of cord ischemia, was not present 24 hours later, and hence appears to be too sensitive to use as an indicator of spinal cord damage. Plotting spinal cord motor-evoked potential amplitude reduction versus both histopathologic damage and regional blood flow revealed a positive correlation between motor-evoked potential amplitude reduction, decreased cord perfusion, and increased histopathologic damage. In addition, it may be possible to make inferences about the neurologic status of a subject based on the magnitude and time-course of the motor-evoked potential's amplitude reduction and wave morphology.
Reuter
D G
DG
Hillenbrand Biomedical Engineering Center, Purdue University, West Lafayette, Ind. 47907.
Tacker
W A
WA
Badylak
S F
SF
Voorhees
W D
WD
Konrad
P E
PE
D000818:Animals; D001014:Aortic Aneurysm / Q000601:surgery; D004285:Dogs; D005071:Evoked Potentials / Q000502:physiology*; D016343:Monitoring, Intraoperative / Q000379:methods*; D009044:Motor Cortex / Q000502:physiology*; D010264:Paraplegia / Q000209:etiology / Q000517:prevention & control; D011183:Postoperative Complications / Q000517:prevention & control; D011237:Predictive Value of Tests; D012039:Regional Blood Flow / Q000502:physiology; D015427:Reperfusion Injury / Q000175:diagnosis* / Q000453:epidemiology; D013116:Spinal Cord / Q000098:blood supply* / Q000473:pathology