title: Salivary testosterone as an index of antiandrogen therapy in hirsutism.
abstract: The purpose of this study is to examine whether salivary testosterone (ST) in hirsute women treated with antiandrogen therapy can be considered a good parameter for the evaluation of clinical response. Twenty-three hirsute women, four with polycystic ovarian disease and 19 with idiopathic hirsutism were treated with cyproterone acetate and ethynyl-oestradiol with levonorgestrel in a reverse sequential regime for three months. Basal ST from hirsute women was 0.18 +/- 0.11 nmol/L (normal values 0.03-0.17) and a decrease to 0.11 +/- 0.06 was observed in the first month of treatment, to 0.1 +/- 0.059 after two months and to 0.11 +/- 0.06 after three months, all of them significantly different from basal values (p < 0.05). We found a relationship between ST decrease and the clinical response to antiandrogen therapy. On the basis of these results we suggest that ST values could be a good index for the follow-up of antiandrogen therapy in hirsute women.
authors.affiliation: Endocrinology Service, Hospital de Bellvitge, Barcelona.
authors.forename: J M
authors.initials: JM
authors.lastname: Gómez
authors.forename: M A
authors.initials: MA
authors.lastname: Navarro
authors.forename: B
authors.initials: B
authors.lastname: Arranz
authors.forename: J
authors.initials: J
authors.lastname: Soler
authors.forename: M R
authors.initials: MR
authors.lastname: Bonnin
authors.forename: E
authors.initials: E
authors.lastname: Montaña
mesh_terms: D000293:Adolescent; D000328:Adult; D000726:Androgen Antagonists / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D017373:Cyproterone Acetate / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004997:Ethinyl Estradiol / Q000627:therapeutic use; D005260:Female; D006628:Hirsutism / Q000188:drug therapy / Q000453:epidemiology / Q000378:metabolism*; D006801:Humans; D008597:Menstrual Cycle / Q000187:drug effects / Q000502:physiology; D012463:Saliva / Q000737:chemistry / Q000187:drug effects*; D013739:Testosterone / Q000032:analysis*
chemical_list: D000726:Androgen Antagonists; D013739:Testosterone; D004997:Ethinyl Estradiol; D017373:Cyproterone Acetate