Inhibitory effect of ginsenosides on migration of arterial smooth muscle cells.
Migration of arterial smooth muscle cells (SMC) in the arterial wall plays an important role in the formation of intimal thickening of atherosclerotic lesions. In this study, we examined the effect of ginsenosides on SMC migration induced by platelet-derived growth factor (PDGF) and SMC-derived migration factor (SDMF). Ginsenosides had inhibitory effects on SMC migration and the striking effects were observed with ginsenoside-Rb2 and -Rc in a dose-dependent manner. These results suggest that the administration of ginsenosides on the patients may prevent intimal thickening, in part, by inhibiting SMC migration in the arterial wall.
Koyama
N
N
Second Department of Internal Medicine, School of Medicine, Chiba University, Japan.
Morisaki
N
N
Saito
Y
Y
Yoshida
S
S
D000818:Animals; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000503:physiopathology; D002465:Cell Movement / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism; D036145:Ginsenosides; D010982:Platelet-Derived Growth Factor / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012503:Saponins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; D010982:Platelet-Derived Growth Factor; D012503:Saponins