title: Linkage analysis and predicting genetic disease.
abstract: Linkage analysis is an important and clinically applicable method of predicting risk for genetic disorders and traits. When a gene cannot be detected directly, evaluation of a closely linked marker may be used in risk assessment. This review of linkage analysis provides basic information and examples of the application of these methods in genetic counseling situations.
authors.affiliation: Department of Obstetrics and Gynecology, University of Maryland School of Medicine, Baltimore.
authors.forename: J A
authors.initials: JA
authors.lastname: Boughman
authors.forename: M J
authors.initials: MJ
authors.lastname: Stick
authors.forename: D A
authors.initials: DA
authors.lastname: Peterson
authors.forename: M M
authors.initials: MM
authors.lastname: Cohen
mesh_terms: D002874:Chromosome Mapping; D005260:Female; D005817:Genetic Counseling; D030342:Genetic Diseases, Inborn / Q000175:diagnosis* / Q000235:genetics; D008040:Genetic Linkage; D015894:Genome, Human; D006801:Humans; D008297:Male; D010375:Pedigree