Genetic markers in alcoholic liver cirrhosis.
11 genetic markers were typed in 157 individuals suffering from alcoholic cirrhosis, and compared with a random sample of healthy individuals. No significant differences were found for transferrin, specific group component, orosomucoid, esterase D, phosphogluconate dehydrogenase and adenylate kinase. Strong associations between alcoholic cirrhosis and alpha-1-antitrypsin PI*Z allele, haptoglobin HP*1 allele and acid phosphatase ACP AC phenotype were observed. The biological significance of these associations and their relationships with the development of alcoholic cirrhosis are also discussed.
Lareu
M V
MV
Institute of Legal Medicine, University of Santiago de Compostela, Spain.
Alvarez-Prechous
A
A
Pardiñas
C
C
Concheiro
L
L
Carracedo
A
A
D000328:Adult; D000368:Aged; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000235:genetics*; D008875:Middle Aged; D010641:Phenotype
D005819:Genetic Markers