Genetic and molecular analysis of recessive alleles at the pink-eyed dilution (p) locus of the mouse.
Recessive mutant alleles at the pink-eyed dilution (p) locus on mouse chromosome 7 reduce pigmentation of both the coat and eyes. Here we describe the properties and complementation interactions of 10 p alleles, including 6 not previously reported. Several alleles that cause additional phenotypes affecting development, reproduction, and behavior were shown to be deletions by using DNA probes derived from the p region. An alignment of functional and marker-defined units is proposed, giving a linear complementation map that orders at least four functional loci. The characterization of a nested set of deletions around p will facilitate detailed molecular analyses of the genes and developmental functions associated with this part of the mouse genome.
Lyon
M F
MF
Medical Research Council Radiobiology Unit, Didcot, Oxon, England.
King
T R
TR
Gondo
Y
Y
Gardner
J M
JM
Nakatsu
Y
Y
Eicher
E M
EM
Brilliant
M H
MH
D000483:Alleles; D000818:Animals; D015139:Blotting, Southern; D002872:Chromosome Deletion; D003433:Crosses, Genetic; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D005127:Eye Color / Q000235:genetics*; D005260:Female; D005808:Genes, Recessive; D005838:Genotype; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008817:Mice, Mutant Strains; D009154:Mutation
D004247:DNA