[Successful nitrogranulogen treatment of severe nephrotic syndrome in glomerulonephritis--case report].
A patient with mesangio-proliferative glomerulopathy with advanced nephrotic syndrome (proteinuria 20 g/day) received bolus doses of corticosteroids (5 x 1.0 g iv) but renal function continued to deteriorate. A 11-day course of nitrogranulogen (0.01 mg/kg/day) with prednisone (0.5 mg/kg) caused complete disappearance of proteinuria with improvement in renal function. This observation supports our earlier findings indicating that treatment with low dose nitrogranulogen may be efficacious in some forms of glomerulopathies.
Imiela
J
J
I Oddział Wewnetrzny Centralnego Szpitala Kolejowego, Warszawie.
Nowaczyk
M
M
Małecki
R
R
Górski
A
A
D004359:Drug Therapy, Combination; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications / Q000188:drug therapy* / Q000652:urine; D006801:Humans; D007678:Kidney Glomerulus / Q000187:drug effects*; D008466:Mechlorethamine / Q000008:administration & dosage*; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000150:complications / Q000188:drug therapy* / Q000652:urine; D011241:Prednisone / Q000008:administration & dosage*; D011507:Proteinuria / Q000188:drug therapy / Q000209:etiology
D008466:Mechlorethamine; D011241:Prednisone
Skuteczne leczenie nitrogranulogenem ciezkiego zespołu nerczycowego w przebiegu kłebkowego zapalenia nerek--opis przypadku.