title: Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II.
abstract: Phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II is believed to control the transition from transcription initiation to elongation. The general transcription factor IIH (TFIIH) contains a kinase activity capable of phosphorylating this domain. Factors that promote the association of RNA polymerase II with the preinitiation complex stimulate this activity. The transcription factor IIE, which is required for the stable association of TFIIH with the preinitiation complex, affects the processivity of TFIIH kinase.
authors.affiliation: Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway 08854-5635.
authors.forename: H
authors.initials: H
authors.lastname: Lu
authors.forename: L
authors.initials: L
authors.lastname: Zawel
authors.forename: L
authors.initials: L
authors.lastname: Fisher
authors.forename: J M
authors.initials: JM
authors.lastname: Egly
authors.forename: D
authors.initials: D
authors.lastname: Reinberg
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000595:Amino Acid Sequence; D003593:Cytoplasm / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D066298:In Vitro Techniques; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism*; D012319:RNA Polymerase II / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism* / Q000648:ultrastructure; D014158:Transcription, Genetic
chemical_list: D046911:Macromolecular Substances; D014157:Transcription Factors; D000255:Adenosine Triphosphate; D004247:DNA; D011494:Protein Kinases; D012319:RNA Polymerase II