The distribution of immunoreactive interferon-gamma-containing cells in normal human tissues.
An immunohistochemical technique has been used to study the distribution of lymphocytes expressing interferon-gamma in normal adult tissues. The greatest concentrations of these cells were seen in mucosal sites exposed to a resident microflora. It is proposed that such organisms, by eliciting immune responses, provide the stimulus for the production of 'physiological' interferon-gamma. This in turn may act to preserve the 'tone' or readiness of the immune system.
Brett
F
F
Department of Pathology, Glasgow Royal Infirmary, U.K.
Mowat
A
A
Farquharson
M A
MA
McGill
M
M
Hind
C
C
Richmond
J
J
Murray
D
D
Khan
N U
NU
Foulis
A K
AK
D000328:Adult; D004064:Digestive System / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D007371:Interferon-gamma / Q000032:analysis* / Q000276:immunology; D007413:Intestinal Mucosa / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D008221:Lymphoid Tissue / Q000276:immunology; D014566:Urogenital System / Q000276:immunology
D007371:Interferon-gamma