Diurnal effect on caffeine acetylation phenotyping: a preliminary report.
The present study examined whether caffeine acetylation phenotype could be altered by its time of administration. Caffeine was given orally to nine healthy subjects at 10 a.m. and 10 p.m. and acetylation phenotype was determined by measuring the major metabolites of caffeine in urine. The results showed that acetylation phenotypes determined in the day trial were not different from those determined during the night trial.
Hashiguchi
M
M
Department of Clinical Pharmacology, Jichi Medical School, Tochigi, Japan.
Fujimura
A
A
Ohashi
K
K
Ebihara
A
A
D000107:Acetylation; D000328:Adult; D002110:Caffeine / Q000378:metabolism* / Q000652:urine; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008297:Male; D010641:Phenotype
D002110:Caffeine