title: [Relationship between chemical structure and toxicologic-pharmacokinetic properties of new ampicillin derivatives].
abstract: The toxicity and the bioavailability of new ampicillin derivatives with glyoxylic acid benzhydrazones as site chain depend on the hydrophobic properties of the site chain. Substituents with lower hydrophobicity (expressed by the hydrophobic substituent constant pi according to Hansch) show a lower toxicity (maximal tolerated doses) and also a lower bioavailability.
authors.affiliation: Institut für Mikrobiologie und experimentelle Therapie (ZIMET), Jena.
authors.forename: H
authors.initials: H
authors.lastname: Willitzer
authors.forename: U
authors.initials: U
authors.lastname: Horn
authors.forename: L
authors.initials: L
authors.lastname: Heinisch
authors.forename: U
authors.initials: U
authors.lastname: Möllmann
authors.forename: K G
authors.initials: KG
authors.lastname: Hanschke
authors.forename: K
authors.initials: K
authors.lastname: Stengel
authors.forename: K
authors.initials: K
authors.lastname: Eckardt
mesh_terms: D000667:Ampicillin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics* / Q000633:toxicity; D000818:Animals; D001682:Biological Availability; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000667:Ampicillin
vernacular_title: Beziehungen zwischen chemischer Struktur und toxikologisch-pharmakokinetischen Eigenschaften neuer Ampicillin-Derivate.