title: Regulation of oxidative activity and delta psi of liver mitochondria of active and hibernating gophers. The role of phospholipase A2.
abstract: 1. In the present work the initially lowered oxidase activity of liver mitochondria of hibernating gophers is shown to increase upon Ca(2+)-loading, after freezing-thawing repeated three times and after swelling in a medium containing potassium acetate as well as in a hypotonic sucrose medium. 2. In all cases the inhibition of phospholipase A2 hindered the increase of the oxidase activity of mitochondria. 3. Mitochondria of hibernating gophers have a lowered delta psi in comparison with active animals, which is restored in the hypotonic medium.
authors.affiliation: Institute of Theoretical and Experimental Biophysics, U.S.S.R. Academy of Sciences, Pushchino, Moscow Region.
authors.forename: N N
authors.initials: NN
authors.lastname: Brustovetsky
authors.forename: M V
authors.initials: MV
authors.lastname: Egorova
authors.forename: E I
authors.initials: EI
authors.lastname: Mayevsky
mesh_terms: D000818:Animals; D006605:Hibernation / Q000502:physiology*; D066298:In Vitro Techniques; D007425:Intracellular Membranes / Q000378:metabolism; D008564:Membrane Potentials; D008930:Mitochondria, Liver / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism; D010101:Oxygen Consumption; D010741:Phospholipases A / Q000378:metabolism*; D054467:Phospholipases A2; D012589:Sciuridae / Q000378:metabolism*
chemical_list: D010088:Oxidoreductases; D010741:Phospholipases A; D054467:Phospholipases A2