title: Decreased behavioral effects of daily intracerebroventricular bombesin.
abstract: Intracerebroventricular (ICV) bombesin increases grooming and decreases food intake in rats. We examined tolerance to these effects by administering a daily injection of either saline or 25 ng bombesin to rats for 8 days via lateral ventricular cannulas. Food intake and grooming were monitored. After 8 days bombesin no longer increased grooming or decreased food intake in bombesin-treated rats, but did increase grooming and decrease food intake in saline-treated rats. This development of behavioral tolerance conflicts with previous reports using larger doses and demonstrates that repeated small doses of ICV bombesin produce different effects from larger doses.
authors.affiliation: Department of Psychiatry, Cornell University Medical College, White Plains, NY.
authors.forename: R L
authors.initials: RL
authors.lastname: Corwin
authors.forename: E S
authors.initials: ES
authors.lastname: Corp
authors.forename: J
authors.initials: J
authors.lastname: Gibbs
authors.forename: G P
authors.initials: GP
authors.lastname: Smith
mesh_terms: D000818:Animals; D001839:Bombesin / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D004361:Drug Tolerance; D005247:Feeding Behavior / Q000187:drug effects*; D006120:Grooming / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D001839:Bombesin