Enhanced induction of lymphokine-activated killer activity after lentinan administration in patients with gastric carcinoma.
In 15 patients with gastric carcinoma, peripheral blood mononuclear cells (PBM) were obtained serially before and 3, 5 and 7 days after lentinan administration. The generation of lymphokine-activated killer (LAK) activity, induced by in vitro activation of PBM with interleukin 2 (IL 2), was significantly augmented 5 days after a single intravenous dose of 2 mg lentinan, when compared with that before lentinan injection. Natural killer (NK) activity of PBM was also significantly enhanced 7 days after the drug injection. However, the distribution of lymphocyte subsets exhibited no significant change following lentinan administration.
Arinaga
S
S
Department of Surgery, Kyushu University, Beppu, Japan.
Karimine
N
N
Takamuku
K
K
Nanbara
S
S
Inoue
H
H
Nagamatsu
M
M
Ueo
H
H
Akiyoshi
T
T
D002469:Cell Separation; D002860:Chromium Radioisotopes; D005434:Flow Cytometry; D006801:Humans; D066298:In Vitro Techniques; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology*; D007912:Lentinan / Q000494:pharmacology*; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008213:Lymphocyte Activation; D013274:Stomach Neoplasms / Q000276:immunology*
D002860:Chromium Radioisotopes; D007912:Lentinan