Rapid induction of atherosclerosis in rabbits.
Japanese white rabbits fed a restricted amount (100 g/head/day) of an atherogenic diet (AD) containing 0.2% cholesterol and 6% peanut oil showed mild and persistent hypercholesterolemia (338 +/- 79 mg/dl). They developed atherosclerotic lesions 4 weeks after deendothelialization of aorta carried out at the 4th week of AD-feeding. This rabbit model of atherosclerosis has such advantages as being able to be produced in a short period and having similar biochemical and pathological characteristics with those in human atherosclerosis.
Saso
Y
Y
Biological Research Laboratory, Tanabe Seiyaku Co. Ltd., Saitama, Japan.
Kitamura
K
K
Yasoshima
A
A
Iwasaki
H O
HO
Takashima
K
K
Doi
K
K
Morita
T
T
D000818:Animals; D001011:Aorta / Q000293:injuries / Q000378:metabolism / Q000473:pathology; D001161:Arteriosclerosis / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D003094:Collagen / Q000378:metabolism; D004036:Diet, Atherogenic; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000293:injuries / Q000473:pathology; D005487:Foam Cells / Q000473:pathology; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D008854:Microscopy, Electron; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D011817:Rabbits; D013997:Time Factors
D008055:Lipids; D003094:Collagen