[Study of intraocular diffusion of ofloxacin in humans and rabbits].
The diffusion of ofloxacin in infected and healthy human and rabbit eyes was investigated. In the human study, cataract surgery patients were given intravenous ofloxacin either as a single 200 or 400 mg dose or as two 400 mg infusions 12 hours apart. Samples of aqueous humor and plasma were collected between 1 and 12 hours after the end of the infusion. Levels in the anterior chamber increased with the dose; peak levels, which occurred after three hours, were 0.33 mg/l after 200 mg and 1.24 mg/l after two 200 mg doses given 12 hours apart. In the rabbit study, 16 hours after experimental infection of the left eye by injection of S. epidermidis into the vitreous, animals were given an intraperitoneal injection of 20 or 50 mg/kg ofloxacin. Dosages in the various ocular tissues showed that penetration into the eye varied with race (albinos greater than pigmented) and dose. Intraocular ofloxacin levels, including in the vitreous, increased two fold when the eye was infected; however, penetration into the sclera, choroid, and retina was comparable in infected and noninfected eyes. These findings in humans and animals suggest that ofloxacin in a dose of a least 400 mg is a useful agent for the treatment of prophylaxis of ocular infections.
Mounier
M
M
Laboratoire de Bactériologie-Virologie, CHU Dupuytren, Limoges.
Ploy
M C
MC
Chauvin
M
M
Adenis
J P
JP
Denis
F
F
D000368:Aged; D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects / Q000378:metabolism / Q000382:microbiology; D002387:Cataract Extraction; D004058:Diffusion; D005123:Eye / Q000187:drug effects / Q000378:metabolism* / Q000382:microbiology; D015818:Eye Infections, Bacterial / Q000188:drug therapy* / Q000382:microbiology / Q000517:prevention & control; D006801:Humans; D007275:Injections, Intravenous; D015242:Ofloxacin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011300:Preoperative Care; D011817:Rabbits; D013212:Staphylococcus epidermidis / Q000302:isolation & purification*
D015242:Ofloxacin
Etude de la pénétration intraoculaire de l'ofloxacine chez l'homme et le lapin.