title: Depudecin: a novel compound inducing the flat phenotype of NIH3T3 cells doubly transformed by ras- and src-oncogene, produced by Alternaria brassicicola.
abstract: A novel compound depudecin inducing the flat phenotype of ras- and src- transformed NIH3T3 cells at a concentration of 1 microgram/ml was isolated from the culture broth of Alternaria brassicicola. Based on its spectroscopic characteristics and X-ray crystallographic analysis of its bis-(1S)-(-)-camphanate, the structure of depudecin was determined to be (2R,3S,4S,5E,7S,8S,9R)-2,9- dihydroxy-3,4;7,8-diepoxy-undeca-5,10-diene.
authors.affiliation: Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: S
authors.initials: S
authors.lastname: Matsutani
authors.forename: K
authors.initials: K
authors.lastname: Sugita
authors.forename: H
authors.initials: H
authors.lastname: Yoshida
authors.forename: F
authors.initials: F
authors.lastname: Hayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Terui
authors.forename: H
authors.initials: H
authors.lastname: Nakai
authors.forename: N
authors.initials: N
authors.lastname: Uotani
authors.forename: Y
authors.initials: Y
authors.lastname: Kawamura
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
mesh_terms: D016475:3T3 Cells / Q000187:drug effects; D000466:Alkadienes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000528:Alternaria / Q000145:classification / Q000378:metabolism*; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D004852:Epoxy Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005233:Fatty Alcohols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D011905:Genes, ras; D016391:Genes, src; D051379:Mice; D010641:Phenotype
chemical_list: D000466:Alkadienes; D004852:Epoxy Compounds; D005233:Fatty Alcohols; C072251:depudecin