title: [Alterations in lymphocyte subsets in variable immunodeficiency syndrome].
abstract: Besides functional defects, different phenotypical alterations of lymphocytes have been described in patients with CVID. A decrease in LAM-1- (= Leu8) and CD21 expression was observed on B cells. Some patients with CVID show alterations in their T-cell subpopulations: The most striking features of this subgroup are low CD4/CD8-ratio, an increase in CD57/CD8 double-positive lymphocytes, and a strong enhancement of HLA-DR and "memory" markers such as CD29 and LFA-3 on T cells.
authors.affiliation: Abteilung Rheumatologie und Klinische Immunologie, Medizinische Universitätsklinik, Freiburg.
authors.forename: E
authors.initials: E
authors.lastname: Baumert
authors.forename: M
authors.initials: M
authors.lastname: Schlesier
authors.forename: G
authors.initials: G
authors.lastname: Wolff-Vorbeck
authors.forename: H H
authors.initials: HH
authors.lastname: Peter
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology; D016516:CD4-CD8 Ratio; D005434:Flow Cytometry; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D007156:Immunologic Memory; D007694:Killer Cells, Natural / Q000276:immunology; D016131:Lymphocyte Subsets / Q000276:immunology*; D009000:Monocytes / Q000276:immunology; D015375:Receptors, Interleukin-2 / Q000032:analysis; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D006684:HLA-DR Antigens; D015375:Receptors, Interleukin-2
vernacular_title: Veränderungen von Lymphozyten-subpopulationen bei variablem Immundefektsyndrom.