Acute pulmonary toxicity of inhaled beta-1,3-glucan and endotoxin.
The number of inflammatory cells was studied in lung walls and airways after inhalation of endotoxin or beta-1,3-glucan. In the water unsoluble form, beta-1,3-glucan caused a delayed response in terms of a decrease in macrophages and lymphocytes in the lung wall, 1 to 7 days after exposure but no invasion of neutrophils into the airways. When solubilized in 0.02 N NaOH, the cell response was the same as that observed after exposure to endotoxin.
Fogelmark
B
B
Department of Environmental Medicine, University of Gothenburg, Sweden.
Goto
H
H
Yuasa
K
K
Marchat
B
B
Rylander
R
R
D000280:Administration, Inhalation; D000818:Animals; D004731:Endotoxins / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D005936:Glucans / Q000008:administration & dosage / Q000633:toxicity*; D006168:Guinea Pigs; D007958:Leukocyte Count; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000139:chemically induced* / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D008297:Male; D009504:Neutrophils / Q000473:pathology; D047071:beta-Glucans
D004731:Endotoxins; D005936:Glucans; D047071:beta-Glucans; C033363:beta-1,3-glucan