title: Relationship between plasma insulin and blood pressure in South African black women in Johannesburg.
abstract: OBJECTIVE
  To examine the relationship between fasting plasma insulin and blood pressure (BP) in 40 urbanized normotensive South African black women aged 24-60 yr, and to assess the effects of body mass index (BMI) and fasting plasma glucose on BP.
  
  
  METHODS
  The women comprised equal numbers of young nonobese nondiabetic subjects, middle-aged nonobese nondiabetic subjects, middle-aged obese nondiabetic subjects, and middle-aged obese newly diagnosed non-insulin-dependent diabetic subjects. Systolic and diastolic BPs were recorded (in duplicate) after 15 min of recumbency, and fasting plasma glucose and insulin levels were determined thereafter. The data were analyzed by simple and multivariate regression.
  
  
  RESULTS
  There was a wide distribution of individual physical and biochemical features. With simple correlations, systolic BP correlated significantly with age, BMI, and fasting glucose but not with insulin. Diastolic BP correlated significantly with all four variables (r = 0.37, P less than 0.05). When adjusted for age, BMI, and glucose, however, the significant correlation between diastolic BP and insulin diminished (r = -0.04).
  
  
  CONCLUSIONS
  As in other nonwhite communities, plasma insulin does not appear to play a major role in regulating the BP of South African black women.
authors.affiliation: Department of Medicine, University of Witwatersrand Medical School, Johannesburg, South Africa.
authors.forename: B I
authors.initials: BI
authors.lastname: Joffe
authors.forename: V R
authors.initials: VR
authors.lastname: Panz
authors.forename: J R
authors.initials: JR
authors.lastname: Wing
authors.forename: F J
authors.initials: FJ
authors.lastname: Raal
authors.forename: H C
authors.initials: HC
authors.lastname: Seftel
mesh_terms: D000328:Adult; D000367:Age Factors; D044383:Black People; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D008875:Middle Aged; D013019:South Africa; D014505:Urban Population
chemical_list: D001786:Blood Glucose; D007328:Insulin