Trisomy 4 in a case of acute lymphocytic leukemia (L1).
Trisomy 4 has been identified previously as a chromosome abnormality associated with acute nonlymphocytic leukemia (ANLL) with myelomonocytic lineage and in myelodysplastic syndromes (MDS). We report a case of acute lymphocytic leukemia (ALL) (French-American-British, FAB L1) in a 42-year-old Japanese man, with trisomy 4 as the sole chromosomal anomaly. Immunophenotypically, the leukemic blasts demonstrated reactivity with CD2, CD5, and CD7 and indicated on early stage of T cell.
Hodohara
K
K
Second Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan.
Fujiyama
Y
Y
Inoue
T
T
Niwakawa
M
M
Kitoh
K
K
Andoh
A
A
Bamba
T
T
Hosoda
S
S
Abe
T
T
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D002894:Chromosomes, Human, Pair 4; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000276:immunology; D014314:Trisomy
D015703:Antigens, CD