title: Recent advances in fluorescence in situ hybridization.
abstract: Fluorescence in situ hybridization (FISH) procedures that directly couple molecular and cytological information allow precise visualization of DNA sequences on metaphase chromosomes and interphase nuclei. These techniques can be used to identify chromosomes, detect chromosomal aberrations, and analyze linear and spatial genome organization. FISH procedures are also used to clinical fields for diagnosis of disease-related chromosome changes and tumor biology.
authors.affiliation: Chromosome Research Unit, Faculty of Science, Hokkaido University, Sapporo, Japan.
authors.forename: M C
authors.initials: MC
authors.lastname: Yoshida
mesh_terms: D000818:Animals; D004247:DNA; D005453:Fluorescence; D006801:Humans; D009693:Nucleic Acid Hybridization
chemical_list: D004247:DNA