title: Phase II evaluation of piroxantrone in renal cell carcinoma. A Southwest Oncology Group Study.
abstract: The Southwest Oncology Group (SWOG) studied the response rate and toxicity of piroxantrone (150 mg/m2 q 21 days) in patients with advanced metastatic renal cell carcinoma. Among 32 eligible patients, there were no partial nor complete responses. There were two mixed responses. Significant white cell toxicity, anemia, nausea, and vomiting were observed. Mild or moderate degrees of fever, malaise, and stomatitis occurred. No significant cardiac toxicity was noted. Piroxantrone does not have significant activity as a single agent in advanced renal cell carcinoma.
authors.affiliation: University of Kansas Medical Center, Kansas City.
authors.forename: A
authors.initials: A
authors.lastname: Allen
authors.forename: M
authors.initials: M
authors.lastname: Wolf
authors.forename: E D
authors.initials: ED
authors.lastname: Crawford
authors.forename: M P
authors.initials: MP
authors.lastname: Davis
authors.forename: R B
authors.initials: RB
authors.lastname: Natale
authors.forename: M L
authors.initials: ML
authors.lastname: Barnett
mesh_terms: D000328:Adult; D000368:Aged; D000880:Anthraquinones / Q000009:adverse effects / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011720:Pyrazoles / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000880:Anthraquinones; D000970:Antineoplastic Agents; D011720:Pyrazoles; C046659:piroxantrone