title: Short-term effect of red wine (consumed during meals) on insulin requirement and glucose tolerance in diabetic patients.
abstract: OBJECTIVE
  To determine the effect of wine on insulin requirement or glucose tolerance.
  
  
  METHODS
  Five men with insulin-treated diabetes and 10 men with non-insulin-treated diabetes ate the same lunch with the same volume of either water or red wine (2 glasses). Insulin requirement was determined with an artificial pancreas (Biostator). Glucose tolerance was evaluated from the postprandial glycemic level.
  
  
  RESULTS
  There was no significant difference in insulin requirement determined with an artificial pancreas in the insulin-treated patients after the two meals (31.5 +/- 4.21 U with water and 31.8 +/- 4.3 U with wine). Glucose tolerance in the non-insulin-treated patients was lower after the meal with wine.
  
  
  CONCLUSIONS
  Moderate prandial wine consumption has no adverse effect on the glycemic control of diabetic patients. Thus, it appears unnecessary to proscribe the consumption of red wine in moderation with meals to diabetic patients. Wine contains tannins and phytates that can explain its action.
authors.affiliation: Tripode Hospital Medical Clinic, University of Bordeaux, France.
authors.forename: H
authors.initials: H
authors.lastname: Gin
authors.forename: P
authors.initials: P
authors.lastname: Morlat
authors.forename: J M
authors.initials: JM
authors.lastname: Ragnaud
authors.forename: J
authors.initials: J
authors.lastname: Aubertin
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004435:Eating; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D007332:Insulin Infusion Systems; D008297:Male; D014867:Water; D014920:Wine
chemical_list: D001786:Blood Glucose; D007328:Insulin; D014867:Water