title: [Long-term sedation with propofol in ICU: hemocoagulation problems].
abstract: The Authors have studied the effects of propofol on coagulation in 15 patients admitted to ICU. Propofol was used for long-term sedation (therapeutic range 3 mg/kg/h). Variables monitored included: platelets, PTT, PT, Fibrinogen, FDP, AT III. The effects on coagulation has been investigated in three groups of patients: group I) 5 patients that received propofol for 1-3 days; group II) 5 patients that received propofol for 4-10 days; group III) 5 patients that received propofol for 11-35 days. No difference were found about blood coagulation in this groups of patients before and after administration of propofol.
authors.affiliation: U.O. Anestesia e Rianimazione, USSL 8, Pistoia.
authors.forename: I
authors.initials: I
authors.lastname: Niccolai
authors.forename: L
authors.initials: L
authors.lastname: Barontini
authors.forename: P
authors.initials: P
authors.lastname: Paolini
authors.forename: L
authors.initials: L
authors.lastname: Lavacchi
authors.forename: G
authors.initials: G
authors.lastname: Bracciotti
authors.forename: F
authors.initials: F
authors.lastname: Pellegrini
authors.forename: F
authors.initials: F
authors.lastname: Aiardi
authors.forename: A
authors.initials: A
authors.lastname: Ferlito
mesh_terms: D000328:Adult; D000368:Aged; D001778:Blood Coagulation Disorders / Q000139:chemically induced*; D016292:Procedural Sedation; D003422:Critical Care; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D015742:Propofol
vernacular_title: Sedazione di lunga durata con propofol in ICU: problemi emocoagulativi.