title: [Clinical activity and serum immunoglobulin concentrations in patients with ankylosing spondylitis].
abstract: Several authors have suggested that immunoglobulin A plays a pathogenic role in ankylosing spondylitis. We have determined the levels of immunoglobulins in 30 patients, observing higher levels than in control patients (248 vs 176 mg/dl); p less than 0.01) and a relation between the increase of immunoglobulin A and the presence of clinical activity in the subgroup of patients B27-negative (163 vs 398 mg/dl, p less than 0.005), but not in B27-positive patients. We think that these e results support the hypothesis that ankylosing spondylitis is an heterogeneous disease, with different pathogenic mechanisms depending on the presence or absence of the serological marker HLA-B27.
authors.affiliation: Servicio de Reumatología, Hospital Universitario de Granada.
authors.forename: J L
authors.initials: JL
authors.lastname: Casals Sánchez
authors.forename: J
authors.initials: J
authors.lastname: González Calvin
authors.forename: A
authors.initials: A
authors.lastname: García Sánchez
authors.forename: M
authors.initials: M
authors.lastname: Abellán Pérez
authors.forename: D
authors.initials: D
authors.lastname: Salvatierra Ríos
mesh_terms: D004198:Disease Susceptibility; D015796:HLA-B27 Antigen / Q000032:analysis*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology*; D007070:Immunoglobulin A / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D013167:Spondylitis, Ankylosing / Q000097:blood / Q000145:classification / Q000235:genetics / Q000276:immunology*
chemical_list: D015796:HLA-B27 Antigen; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M
vernacular_title: Estudio de la actividad clínica y de las concentraciones séricas de inmunoglobulinas en pacientes con espondilitis anquilosante.