title: Testicular relapse in adult acute myelogenous leukemia.
abstract: Testicular relapse (TR) in adult acute myelogenous leukemia (AML) is uncommon, occurring in only 1-2% of patients with bone marrow relapse. TR in the absence of systemic relapse has been reported previously in 2 adults and 12 children, of which 67% were monocytic variants of AML. This article presents the case of a 29-year-old man with AML that relapsed in his testicle without evidence of bone marrow relapse. This patient and the two previously mentioned adults experienced bone marrow relapse within 2 months and died within 7 months of their TR. TR in adult myelogenous leukemia should be considered a harbinger of systemic relapse and suggests a need for aggressive local and systemic therapy.
authors.affiliation: Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, TX 78234-6200.
authors.forename: D W
authors.initials: DW
authors.lastname: Shaffer
authors.forename: H A
authors.initials: HA
authors.lastname: Burris
authors.forename: T J
authors.initials: TJ
authors.lastname: O'Rourke
mesh_terms: D000328:Adult; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D012008:Recurrence; D012074:Remission Induction; D013736:Testicular Neoplasms / Q000175:diagnosis* / Q000628:therapy