title: A new class of alkaloids from a dendrobatid poison frog: a structure for alkaloid 251F.
abstract: Alkaloids of a new class are present in skin extracts of the dendrobatid poison frog, Minyobates bombetes, of Colombia. The structure of the major alkaloid of this class, 251F, has been determined as a trimethylcyclopenta[b]quinolizidinemethanol 1 by nmr, gc-Ft-ir, and ms studies including ms-ms. At least nine congeners of 251F were detected in these extracts.
authors.affiliation: Laboratory of Bioorganic Chemistry, National Institute of Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892.
authors.forename: T F
authors.initials: TF
authors.lastname: Spande
authors.forename: H M
authors.initials: HM
authors.lastname: Garraffo
authors.forename: H J
authors.initials: HJ
authors.lastname: Yeh
authors.forename: Q L
authors.initials: QL
authors.lastname: Pu
authors.forename: L K
authors.initials: LK
authors.lastname: Pannell
authors.forename: J W
authors.initials: JW
authors.lastname: Daly
mesh_terms: D000470:Alkaloids / Q000032:analysis* / Q000737:chemistry; D000818:Animals; D001001:Anura / Q000378:metabolism*; D003105:Colombia; D013058:Mass Spectrometry; D012867:Skin / Q000737:chemistry
chemical_list: D000470:Alkaloids