title: Hippocampal kindling leads to different changes in paired-pulse depression of local evoked field potentials in CA1 area and in fascia dentata.
abstract: Monosynaptic evoked field potentials (EPs) in response to paired-pulse stimulation (20 ms interval) were recorded in area CA1 and fascia dentata of the same animal in the course of development of a kindled focus in the CA1 region. A significant reduction of paired pulse depression in response to medium and high stimulation intensity was found in CA1. A similar change was found in the fascia dentata in response to medium intensity stimulation of the angular bundle. In contrast, at high intensity, paired pulse depression was enhanced in the fascia dentata in the course of kindling. These results indicate that kindling epileptogenesis is accompanied by regionally different changes in recurrent inhibition: a reduction in CA1 and intensity dependent changes in fascia dentata.
authors.affiliation: Department of Experimental Zoology, University of Amsterdam, Netherlands.
authors.forename: W
authors.initials: W
authors.lastname: Kamphuis
authors.forename: J A
authors.initials: JA
authors.lastname: Gorter
authors.forename: W J
authors.initials: WJ
authors.lastname: Wadman
authors.forename: F H
authors.initials: FH
authors.lastname: Lopes da Silva
mesh_terms: D000818:Animals; D004567:Electrodes, Implanted; D005071:Evoked Potentials / Q000502:physiology; D006624:Hippocampus / Q000033:anatomy & histology / Q000502:physiology*; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013569:Synapses / Q000502:physiology