title: Elevated levels of the IgG2 subclass in serum from patients with a history of destructive periodontal disease. A case-control study.
abstract: The levels of the 4 subclasses of IgG were estimated in the serum from 35 patients with a history of chronic periodontitis and 35 matched controls. The levels of IgG2 were significantly (P less than 0.019) elevated in the patients (3.756 g l-1) compared to the controls (2.882 g l-1). The data suggest that the predominant antibody response to periodontal pathogens in periodontitis may be directed against carbohydrate or glycolipid antigens.
authors.affiliation: Medical Research Council Dental Research Unit, London Hospital Medical College, UK.
authors.forename: J M
authors.initials: JM
authors.lastname: Wilton
authors.forename: T J
authors.initials: TJ
authors.lastname: Hurst
authors.forename: J A
authors.initials: JA
authors.lastname: Sterne
authors.forename: J
authors.initials: J
authors.lastname: Caves
authors.forename: C
authors.initials: C
authors.lastname: Tilley
authors.forename: J R
authors.initials: JR
authors.lastname: Powell
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003728:Dental Calculus / Q000473:pathology; D003773:Dental Plaque / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005884:Gingival Hemorrhage / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D010514:Periodontal Pocket / Q000097:blood / Q000473:pathology; D010518:Periodontitis / Q000097:blood* / Q000473:pathology
chemical_list: D007074:Immunoglobulin G