title: NMR spectroscopic and magnetoencephalographic studies in migraine with aura: support for the spreading depression hypothesis.
abstract: The authors propose that patients who suffer from migraine with aura have a susceptibility to spontaneous neuronal discharges and subsequent spreading depression. This is based upon a state of central neuronal excitability involving the excitatory neurotransmitter glutamate, in combination with supersensitivity of the N-méthyl-D-aspartate (NMDA) receptor. This hypersusceptibility is supported by increased turnover of high-energy phosphates, low intracellular Mg2+ and large amplitude depolarizing waves on magnetoencephalography (MEG).
authors.affiliation: William T. Gossett Chairs Department of Neurology, Henry Ford Hospital, Detroit, MI 48202.
authors.forename: K M
authors.initials: KM
authors.lastname: Welch
authors.forename: G L
authors.initials: GL
authors.lastname: Barkley
authors.forename: N M
authors.initials: NM
authors.lastname: Ramadan
authors.forename: G
authors.initials: G
authors.lastname: D'Andrea
mesh_terms: D013181:Cortical Spreading Depression / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D002546:Ischemic Attack, Transient / Q000150:complications / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D015225:Magnetoencephalography / Q000379:methods*; D008881:Migraine Disorders / Q000000981:diagnostic imaging* / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D010710:Phosphates / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D011859:Radiography; D012016:Reference Values
chemical_list: D010710:Phosphates; D010725:Phosphocreatine; D008274:Magnesium