Treatment of pyoderma gangrenosum with cyclosporine.
METHODS
Pyoderma gangrenosum is a chronic inflammatory ulcerative skin disease of unknown origin, often associated with various diseases including inflammatory bowel disease, inflammatory arthritis, monoclonal gammopathies, hepatitis, and myeloproliferative disorders. Treatment of associated systemic disorders may improve the ulcers, but lesions may be recalcitrant and persist for months to years. Therapy for pyoderma gangrenosum includes high-dose systemic corticosteroids, sulfa drugs such as sulfasalazine, clofazimine, and immunosuppressive agents such as mercaptopurine and azathioprine; these drugs are sometimes ineffective.


RESULTS
We present a series of 11 patients with pyoderma gangrenosum, with a wide range of underlying diseases, whose ulcers were refractory to usual therapy and who were treated with low-dose cyclosporine. Ten of the 11 patients cleared rapidly and completely with cyclosporine therapy.


CONCLUSIONS
Cyclosporine should be seriously considered as a primary form of treatment for pyoderma gangrenosum.
Matis
W L
WL
Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia.
Ellis
C N
CN
Griffiths
C E
CE
Lazarus
G S
GS
D000328:Adult; D016572:Cyclosporine / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D005734:Gangrene / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011711:Pyoderma / Q000188:drug therapy* / Q000473:pathology; D012008:Recurrence
D016572:Cyclosporine