title: Age-dependent changes in cat masseter nerve: an electrophysiological and morphological study.
abstract: The present study was undertaken to determine the manner in which aging affects the function and structure of the masseter nerve in old cats. Electrophysiological data demonstrated a significant decrease in the conduction velocity of the action potential in old cats compared with that observed in adult cats. Light microscopic analyses revealed an age-dependent decrease in axon diameter. Electron microscopic observations of the masseter nerve in the aged cats revealed a disruption of the myelin sheaths and a pronounced increase in collagen fibers in the endoneurium and perineurium. These morphological changes are discussed and then related to the decrease in conduction velocity which was observed in the electrophysiological portion of this study.
authors.affiliation: Department of Physiology, UCLA School of Medicine 90024.
authors.forename: M H
authors.initials: MH
authors.lastname: Chase
authors.forename: J K
authors.initials: JK
authors.lastname: Engelhardt
authors.forename: A M
authors.initials: AM
authors.lastname: Adinolfi
authors.forename: S S
authors.initials: SS
authors.lastname: Chirwa
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001369:Axons / Q000502:physiology / Q000648:ultrastructure; D002415:Cats; D008340:Mandibular Nerve / Q000166:cytology / Q000254:growth & development / Q000502:physiology*; D008406:Masseter Muscle / Q000254:growth & development / Q000294:innervation*; D008854:Microscopy, Electron; D024510:Muscle Development; D009186:Myelin Sheath / Q000502:physiology / Q000648:ultrastructure; D009431:Neural Conduction; D009474:Neurons / Q000166:cytology / Q000502:physiology* / Q000648:ultrastructure