An effect of LP-805 as an inducer of endothelium-derived nitric oxide on systemic vasodilation in vivo.
Inazu
M
M
POLA Pharmaceutical R & D Laboratory, Yokohama, Japan.
Kishii
K
K
Morimoto
T
T
Momota
Y
Y
Tujitani
M
M
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism*; D006339:Heart Rate / Q000187:drug effects; D009569:Nitric Oxide / Q000378:metabolism*; D011720:Pyrazoles / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D013552:Swine; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*
D011720:Pyrazoles; D011743:Pyrimidines; D014665:Vasodilator Agents; C073993:8-tert-butyl-6,7-dihydropyrrolo(3,2-e)-5-methylpyrazolo(1,5-a)pyrimidine-3-carbonitrile; D009569:Nitric Oxide