title: Tuberculosis and HIV infection in sub-Saharan Africa.
abstract: OBJECTIVE
  To review the epidemiologic, clinical, and pathological characteristics and the public health implications of human immunodeficiency virus (HIV)-associated tuberculosis in sub-Saharan Africa.
  
  
  METHODS
  Published medical literature (English and French) and proceedings of international and African conferences on the acquired immunodeficiency syndrome (AIDS).
  
  
  METHODS
  Selection by the authors of articles most pertinent to HIV infection and tuberculosis in Africa and internationally.
  
  
  METHODS
  Direct reporting of quantitative data (eg, HIV seroprevalence levels) and of qualitative descriptions and conclusions from selected literature.
  
  
  RESULTS
  High rates (20% to 67%) of HIV infection in patients with tuberculosis have been reported from East, West, Central, and Southern Africa. An increase in tuberculosis cases has been reported at the same time as the emergence of AIDS in several countries. Autopsies in Abidjan, Ivory Coast (Côte d'Ivoire), have shown tuberculosis as the most frequent opportunistic infection in patients dying of AIDS. Clinical differences in patients with tuberculosis who were HIV-positive and HIV-negative are reviewed, the most important being a greatly increased mortality rate in HIV-associated disease. Access to HIV testing is required for firm diagnosis, for clinical care and counseling, and for public health surveillance.
  
  
  CONCLUSIONS
  The epidemiology of tuberculosis has been profoundly influenced by the epidemic of HIV infection in sub-Saharan Africa. Greatly increased human and material resources are required for this neglected problem in international health.
authors.affiliation: Projet RETRO-CI, Abidjan, Ivory Coast.
authors.forename: K M
authors.initials: KM
authors.lastname: De Cock
authors.forename: B
authors.initials: B
authors.lastname: Soro
authors.forename: I M
authors.initials: IM
authors.lastname: Coulibaly
authors.forename: S B
authors.initials: SB
authors.lastname: Lucas
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000453:epidemiology; D000328:Adult; D000349:Africa / Q000453:epidemiology; D004196:Disease Outbreaks; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology*; D015528:HIV Seroprevalence; D006801:Humans; D015994:Incidence; D011159:Population Surveillance; D015995:Prevalence; D014376:Tuberculosis / Q000453:epidemiology* / Q000209:etiology