[Changes in the sensitivity of mice to the action of gamma irradiation by Viscum album L. polysaccharides].
The influence of water-soluble polysaccharides of Viscum album L. on the survival of mice subjected to whole-body gamma-irradiation has been investigated. Polysaccharides were shown to exert a radioprotective effect which was a function of both the radiation dose and the drug dose and time of its injection. The maximum radioprotective efficacy of polysaccharides was observed after their injection 15 min before irradiation. A single intraperitoneal administration of polysaccharides (25 mg/kg) before irradiation with LD50/30 and LD100/10-12 increased the 60-day survival rate up to 95% and 27% respectively. The postirradiation injection of polysaccharides prevented death of 80% of mice given LD50 and increased the average life expectancy of animals irradiated with absolutely lethal doses.
Narimanov
A A
AA
Popova
O I
OI
Murav'eva
D A
DA
D000818:Animals; D002588:Cesium Radioisotopes / Q000494:pharmacology*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010944:Plants; D011134:Polysaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D011829:Radiation Dosage; D011837:Radiation-Protective Agents; D013997:Time Factors; D014916:Whole-Body Irradiation
D002588:Cesium Radioisotopes; D011134:Polysaccharides; D011837:Radiation-Protective Agents
Izmenenie chuvstvitel'nosti mysheĭ k deĭstviiu gamma-radiatsii s pomoshch'iu polisakharidov omely beloĭ (Viscum album L.).