Ammonia: a possible promotor in Helicobacter pylori-related gastric carcinogenesis.
Helicobacter pylori (HP) has been shown to possibly be a pathogen of gastric carcinoma. HP has urease activity and produces ammonia in the stomach. In this study, the role of ammonia on gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were investigated in rats. After 24 weeks pretreatment with MNNG (83 mg/l), 0.01% ammonia or tap water as a drinking water was administered for 24 weeks. The ammonia-treated rats showed a significantly higher incidence of gastric cancer (percent of animals with tumors and number of tumors per rat). Ammonia would thus appear to have an important role in HP-related human gastric carcinogenesis.
Tsujii
M
M
Department of Medicine, Osaka University Medical School, Japan.
Kawano
S
S
Tsuji
S
S
Nagano
K
K
Ito
T
T
Hayashi
N
N
Fusamoto
H
H
Kamada
T
T
Tamura
K
K
D000230:Adenocarcinoma / Q000139:chemically induced*; D000284:Administration, Oral; D000641:Ammonia / Q000633:toxicity*; D000818:Animals; D002471:Cell Transformation, Neoplastic; D016480:Helicobacter pylori / Q000472:pathogenicity; D008297:Male; D008769:Methylnitronitrosoguanidine; D051381:Rats; D011919:Rats, Inbred Strains; D013274:Stomach Neoplasms / Q000139:chemically induced*
D008769:Methylnitronitrosoguanidine; D000641:Ammonia