title: Effects of oxygen inhalation on skin microcirculation in patients with peripheral arterial occlusive disease.
abstract: BACKGROUND
  Oxygen administration is currently used in clinical medicine to improve peripheral oxygen delivery to tissues threatened by ischemia. However, conflicting results have been reported on the effects of oxygen in ischemic areas. This study was aimed at investigating the effects of 40% oxygen inhalation on the skin microcirculation in the feet of patients with peripheral arterial occlusive disease (PAOD).
  
  
  RESULTS
  Transcutaneous oxygen tension (tc PO2) was measured on the dorsal skin of the foot, and the nailfold microcirculation was investigated by a combination of laser Doppler flowmetry (LDF) and dynamic capillaroscopy (CBV) in the great toes of 17 legs of 11 patients, with 13 legs of eight normal subjects as a control group. Inhalation of oxygen induced a significant decrease of both the total (delta LDF, -307%, p less than 0.02) and nutritional (delta CBV, -17%, p less 0.002) skin microcirculation in normal legs compared with baseline values. A similar response was observed in 10 legs of patients who showed a significant increase of the tc PO2 (greater than or equal to 10 mm Hg) (delta LDF, -14%, NS; delta CBV, -13%, p less than 0.005). By contrast, both the total (+21%, p less than 0.03) and nutritional (+52%, p less than 0.05) circulation significantly increased in the seven legs without significant tc PO2 increase. In addition, the flow motion, which was impaired in the patients, was significantly (p less than 0.05) improved by oxygen inhalation.
  
  
  CONCLUSIONS
  Inhalation of 40% oxygen induces a vasoconstriction in the skin microcirculation of toes of the normal subjects and patients with moderate PAOD but induces an increase of the skin microcirculation in patients with severe PAOD.
authors.affiliation: Department of Medicine, University Hospital of Geneva, Switzerland.
authors.forename: O
authors.initials: O
authors.lastname: Bongard
authors.forename: H
authors.initials: H
authors.lastname: Bounameaux
authors.forename: B
authors.initials: B
authors.lastname: Fagrell
mesh_terms: D000280:Administration, Inhalation; D001157:Arterial Occlusive Diseases / Q000503:physiopathology*; D001783:Blood Flow Velocity; D006801:Humans; D007834:Lasers; D007866:Leg / Q000098:blood supply*; D008833:Microcirculation / Q000187:drug effects; D010100:Oxygen / Q000494:pharmacology*; D012016:Reference Values; D012039:Regional Blood Flow; D012146:Rest; D012867:Skin / Q000098:blood supply*; D014465:Ultrasonics
chemical_list: D010100:Oxygen