title: A dose-range study of intrathecal meperidine combined with bupivacaine.
abstract: Twenty-one patients were included in a randomized study to receive either 10 mg of 0.5% hyperbaric bupivacaine alone or combined with 0.05, 0.1, 0.2, 0.3, 0.4 or 0.5 mg.kg-1 meperidine for spinal anaesthesia. Sensory blockade was assessed by pin prick, motor blockade by the Bromage scale, and postoperative analgesia by VAS scores and by the time before the first demand for analgesia. Spinal meperidine did not change the duration of sensory blockade, but induced a dose-related increase in postoperative efficient analgesia. Spinal meperidine might be considered as a means to obtain postoperative analgesia in the hours immediately following surgery.
authors.affiliation: Service d'Anesthésie Réanimation, Hôpital Henri Mondor Créteil, France.
authors.forename: T V
authors.initials: TV
authors.lastname: Thi
authors.forename: G
authors.initials: G
authors.lastname: Orliaguet
authors.forename: N
authors.initials: N
authors.lastname: Liu
authors.forename: L
authors.initials: L
authors.lastname: Delaunay
authors.forename: F
authors.initials: F
authors.lastname: Bonnet
mesh_terms: D000368:Aged; D000775:Anesthesia, Spinal; D002045:Bupivacaine / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D008614:Meperidine / Q000008:administration & dosage*; D008875:Middle Aged; D009985:Orthopedics
chemical_list: D008614:Meperidine; D002045:Bupivacaine