An investigation of the effect of midazolam on the pain experience.
In a randomised, double-blind, cross-over study on 20 healthy human volunteers, the effect of intravenous midazolam on pain tolerance using the 'submaximum effort tourniquet technique' is described. Intravenous midazolam administered in conscious sedation doses was found to significantly reduce the affective and motivational component of the pain experience.
Coulthard
P
P
Department of Oral and Maxillofacial Surgery, Turner Dental School, University Dental Hospital, Manchester.
Rood
J P
JP
D000328:Adult; D016292:Procedural Sedation; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008874:Midazolam / Q000008:administration & dosage / Q000627:therapeutic use*; D010146:Pain / Q000503:physiopathology / Q000517:prevention & control*; D010147:Pain Measurement / Q000379:methods; D013997:Time Factors
D008874:Midazolam