The TGF-beta-related DVR gene family in mammalian development.
The genes that encode the bone morphogenetic proteins and the Vg-related proteins are mammalian members of a group of TGF-beta-related genes, designated the DVR family, that includes the decapentaplegic gene of Drosophila and the Vg1 gene of Xenopus. Members of the DVR (decapentaplegic-Vg-related) family have been implicated in diverse processes during development, particularly in epithelial-mesenchymal interactions. The results of our in situ hybridization studies with postimplantation mouse embryos provide evidence for the involvement of DVR family members, particularly DVR-2, DVR-4 and DVR-6, in specific inductive interactions during the development of many organs, including the limb, the whisker follicle and the heart.
Lyons
K M
KM
Department of Cell Biology, Vanderbilt University, Nashville, TN 37232.
Jones
C M
CM
Hogan
B L
BL
D000818:Animals; D004627:Embryonic Induction / Q000502:physiology; D005314:Embryonic and Fetal Development / Q000502:physiology*; D005326:Fetal Proteins / Q000502:physiology; D015870:Gene Expression / Q000502:physiology; D008322:Mammals / Q000235:genetics*; D005810:Multigene Family / Q000235:genetics*; D016212:Transforming Growth Factor beta / Q000235:genetics*; D014738:Vibrissae / Q000196:embryology
D005326:Fetal Proteins; D016212:Transforming Growth Factor beta