Bcl-2: a repressor of lymphocyte death.
The genes and mechanisms that control programmed cell death are currently the subject of intense study. The bcl-2 gene, a repressor of lymphocyte death, is perhaps the best understood of the programmed cell death associated genes. Here, Stanley Korsmeyer provides a brief overview of bcl-2, concentrating on its roles in B- and T-cell development and in oncogenesis.
Korsmeyer
S J
SJ
Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110.
D000818:Animals; D001402:B-Lymphocytes; D016923:Cell Death / Q000235:genetics*; D019204:GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D008213:Lymphocyte Activation; D008223:Lymphoma / Q000235:genetics / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D019253:Proto-Oncogene Proteins c-bcl-2; D012097:Repressor Proteins / Q000235:genetics*; D013601:T-Lymphocytes
D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D012097:Repressor Proteins; D019204:GTP-Binding Proteins