Prolactin induces growth-related gene expression in rat aortic smooth muscle in vivo.
We examined the effects of in vivo administration of prolactin on growth-related gene expression in aorta. Optimal mRNA expression for both the proto-oncogene, c-myc and ornithine decarboxylase occurred at 22 mg/kg prolactin. For c-myc, this was seen as early as 15 min. Prolactin-induced ornithine decarboxylase mRNA expression began at 1 h. The results confirm work showing induction of these genes by prolactin in tissues where it is mitogenic and supports a role for prolactin in the trophic response of vascular smooth muscle.
Sauro
M D
MD
Department of Immunology, Masonic Medical Research Laboratory, Utica, NY 13501-1787.
Bing
B
B
Zorn
N E
NE
D000199:Actins / Q000235:genetics; D000818:Animals; D001011:Aorta; D015152:Blotting, Northern; D004305:Dose-Response Relationship, Drug; D005786:Gene Expression Regulation / Q000187:drug effects*; D016259:Genes, myc; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism; D009955:Ornithine Decarboxylase / Q000235:genetics*; D011388:Prolactin / Q000008:administration & dosage / Q000494:pharmacology*; D012333:RNA, Messenger / Q000737:chemistry / Q000235:genetics; D051381:Rats; D011919:Rats, Inbred Strains
D000199:Actins; D012333:RNA, Messenger; D011388:Prolactin; D009955:Ornithine Decarboxylase