title: The effect of dietary yeast on the activity of stable chronic Crohn's disease.
abstract: The effect of dietary yeast on the activity of stable Crohn's disease was assessed in 19 patients. During the 1st month patients continued their usual diet (base-line period), but during the next 2 months dietary yeast was excluded except that during 1 month patients took baker's yeast capsules while for the other month they took placebo capsules. The patients' mean Pettit Crohn's disease activity index (CDAI) while taking baker's yeast (mean, 107.9; SE, 6.1) was significantly greater than during yeast exclusion (mean, 102.1; SE, 5.7; p less than 0.05). The mean of each patient's maximum CDAI during yeast exclusion (mean, 107.1; SE, 5.7) was significantly lower than those during the base-line (mean, 115.2; SE, 6.1; p less than 0.05) and baker's yeast inclusion periods (mean, 113.9; SE, 6.7; p less than 0.05). Patients with elevated yeast antibodies tended to develop a higher CDAI while receiving baker's yeast (13 of 15). These results suggest that dietary yeast may affect the activity of Crohn's disease.
authors.affiliation: Dept. of Clinical Pharmacology, Ninewells Hospital, Dundee, Scotland.
authors.forename: G R
authors.initials: GR
authors.lastname: Barclay
authors.forename: H
authors.initials: H
authors.lastname: McKenzie
authors.forename: J
authors.initials: J
authors.lastname: Pennington
authors.forename: D
authors.initials: D
authors.lastname: Parratt
authors.forename: C R
authors.initials: CR
authors.lastname: Pennington
mesh_terms: D000328:Adult; D000908:Antibodies, Fungal / Q000032:analysis*; D003424:Crohn Disease / Q000188:drug therapy / Q000276:immunology*; D004311:Double-Blind Method; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D012441:Saccharomyces cerevisiae / Q000276:immunology*; D015002:Yeast, Dried / Q000008:administration & dosage*
chemical_list: D000908:Antibodies, Fungal