Induction of neoplasms in Egyptian toads Bufo regularis by oil of chenopodium.
Feeding the Egyptian toad Bufo regularis with oil of the chenopodium plant induced hepatocellular carcinomas in 23% of the animals, and metastases of the primary liver tumors appeared in the kidneys of 6 toads. The earliest evidence of tumors appeared after 3 months of treatment. The average latent period of tumor induction was 3.6 +/- 0.4 months. It is speculated that oil of chenopodium may be one of the constituents of Chenopodium ambrosoides which is responsible for tumor induction in the toads B. regularis.
el-Mofty
M M
MM
Zoology Department, Faculty of Science, Alexandria University, Egypt.
Khudoley
V V
VV
Sakr
S A
SA
Ganem
N F
NF
D000818:Animals; D000871:Anthelmintics / Q000633:toxicity; D002025:Bufonidae / Q000502:physiology*; D002273:Carcinogens / Q000633:toxicity*; D004195:Disease Models, Animal; D005260:Female; D007680:Kidney Neoplasms / Q000556:secondary; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D010938:Plant Oils / Q000633:toxicity*; D010946:Plants, Medicinal; D013729:Terpenes / Q000633:toxicity*
D000871:Anthelmintics; D002273:Carcinogens; D010938:Plant Oils; D013729:Terpenes; C075975:oil of Chenopodium