Effect of ambroxol on rabbit eustachian tube surfactant.
The effect of ambroxol administration on phospholipid and phosphatidyl-choline contents of rabbit eustachian tube and lung washings and on [14C]-choline incorporation by rabbit eustachian tube and lung tissue has been studied. Despite minor differences, the drug exerts the same activating effect in both locations. The results add a further piece of evidence to the several similarities existing between the lung surfactant and the surface-active substances present on the eustachian tube.
Mira
E
E
Clinica Otorinolaringoiatrica, Università di Pavia, Italia.
Benazzo
M
M
Manzoni
M
M
Lligona
L
L
Salmona
M
M
Tacconi
M T
MT
D000551:Ambroxol / Q000494:pharmacology*; D000818:Animals; D005064:Eustachian Tube / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000032:analysis; D010713:Phosphatidylcholines / Q000032:analysis* / Q000096:biosynthesis / Q000737:chemistry; D010743:Phospholipids / Q000032:analysis*; D011663:Pulmonary Surfactants / Q000737:chemistry / Q000187:drug effects*; D011817:Rabbits; D013501:Surface-Active Agents / Q000737:chemistry*
D010169:Palmitic Acids; D010713:Phosphatidylcholines; D010743:Phospholipids; D011663:Pulmonary Surfactants; D013501:Surface-Active Agents; D000551:Ambroxol; D019308:Palmitic Acid