Antibacterial activity of N-[2-(dodecanoylmethylamine)ethyl]-alkyl dimethylammonium bromides.
The study contains the results of determination of antibacterial activity of the newly synthesized series of N-[2-(dodecanoylmethylamine)ethyl]-alkyldimethylammonium bromides. The efficiency of the compounds has been characterized towards three species of the genus Clostridium such as Clostridium perfringens, type A, Clostridium bifermentans, Clostridium sporogenes and one strain of the genus Lactobacillus such as Lactobacillus yamanashiensis. The antibacterial activity of the studied compounds has been tested in different time intervals. Out of seven investigated compounds, four compounds exerted the pronounced antibacterial activity on Clostridia (CMIC equals to 0.0039-0.0078 mmol/litre) and three compounds influenced the growth of Lactobacillus yamanashiensis (MIC equals to 0.004-0.006 mmol/litre). The most effective compound was found to be n-octyl derivative. These compounds were more effective towards the tested Clostridia strains than the comparing standard disinfectant such as Ajatin.
Cigáneková
V
V
Department of Microbiology and Virology, Faculty of Natural Sciences, Comenius University, Bratislava, CSFR.
Kallová
J
J
D003013:Clostridium / Q000187:drug effects*; D003016:Clostridium perfringens / Q000187:drug effects*; D004202:Disinfectants / Q000494:pharmacology*; D007778:Lactobacillus / Q000187:drug effects*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*
D004202:Disinfectants; D000644:Quaternary Ammonium Compounds