title: Reactogenicity and immunogenicity of a double-strength acellular pertussis vaccine.
abstract: The reactogenicity and immunogenicity of a double-strength acellular pertussis vaccine were evaluated after administration to 16 4-6-year-old children. The vaccine contained toxoided lymphocytosis-promoting factor (6.0 micrograms/dose), filamentous haemagglutinin (70 micrograms/dose), agglutinogens (1.4 micrograms/dose) and the 69 kDa protein (approximately 8.0 micrograms/dose). The vaccine was extremely well tolerated with few minor side effects following immunization. Significant increases in antibodies to all pertussis vaccine components were noted. In summary, this double-strength acellular pertussis vaccine, containing a very high dose of filamentous haemagglutinin, had minimal reactogenicity and was immunogenic. These findings, as well as other studies with this vaccine, indicate that filamentous haemagglutinin is not a major determinant of vaccine reactogenicity.
authors.affiliation: Department of Pediatrics, UCLA School of Medicine.
authors.forename: D A
authors.initials: DA
authors.lastname: Blumberg
authors.forename: P C
authors.initials: PC
authors.lastname: Chatfield
authors.forename: J D
authors.initials: JD
authors.lastname: Cherry
authors.forename: R G
authors.initials: RG
authors.lastname: Robinson
authors.forename: K
authors.initials: K
authors.lastname: Smith
authors.forename: L
authors.initials: L
authors.lastname: Mabie
authors.forename: H J
authors.initials: HJ
authors.lastname: Holroyd
authors.forename: L R
authors.initials: LR
authors.lastname: Baker
authors.forename: F E
authors.initials: FE
authors.lastname: Dudenhoeffer
authors.forename: N
authors.initials: N
authors.lastname: Apau
mesh_terms: D000907:Antibodies, Bacterial / Q000096:biosynthesis; D001886:Bordetella pertussis / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D010567:Pertussis Vaccine / Q000009:adverse effects / Q000276:immunology / Q000302:isolation & purification*
chemical_list: D000907:Antibodies, Bacterial; D010567:Pertussis Vaccine