title: Inhibition of cytokinesis by lead (Pb2+) in a centric diatom.
abstract: Effect of inorganic and organo lead has been studied on the mitosis of a centric diatom Cyclotella meneghiniana f. unipunctata. Binucleate cells were formed in the presence of different concentrations of Pb2+ (1.0, 2.0, 3.0 and 5.0 mM) due to inhibition of cell plate formation. Lead at 5.0 mM concentration was more inhibitory than the other concentrations. Organo lead was a powerful depressant of cytokinesis than inorganic lead. Failure of cytokinesis might be due to disruption of microtubules. Formation of distinct nuclei delayed post incubation cell divisions suggest partial damage of mitotic spindles.
authors.affiliation: Department of Life Sciences, Rajghat Education Centre, Krishnamurti Foundation India, Varanasi.
authors.forename: B S
authors.initials: BS
authors.lastname: Giri
authors.forename: N A
authors.initials: NA
authors.lastname: Devi
mesh_terms: D002455:Cell Division / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D056890:Eukaryota / Q000187:drug effects*; D007854:Lead / Q000494:pharmacology*; D009566:Nitrates / Q000494:pharmacology; D013756:Tetraethyl Lead / Q000494:pharmacology
chemical_list: D009566:Nitrates; D013756:Tetraethyl Lead; D007854:Lead; C029891:lead chloride; C017461:lead nitrate