Microcephalic cerebrum with hypomyelination in the congenital goiter mouse (cog).
2',3'-Cyclic nucleotide 3'-phosphohydrolase activity in the cerebrum of the congenital goiter mouse (cog/cog) is reduced in comparison with the normal heterozygote (cog/+). The weight of the cog/cog cerebrum and cerebellum were significantly less than those of the normal controls, 89.0% less for the cerebrum, and 81.1% less for the cerebellum. However, no differences were observed with regard to DNA and RNA content and the RNA/DNA ratio. The results of this study indicate that hypomyelination in the congenital goiter mouse is restricted to the cerebrum, and is not related to arrested glial proliferation.
Sugisaki
T
T
Department of Physiology, Toho University School of Medicine, Tokyo, Japan.
Beamer
W G
WG
Noguchi
T
T
D000818:Animals; D001921:Brain / Q000002:abnormalities*; D002455:Cell Division / Q000502:physiology; D004195:Disease Models, Animal; D006042:Goiter / Q000151:congenital / Q000473:pathology* / Q000503:physiopathology; D051379:Mice; D008817:Mice, Mutant Strains; D008831:Microcephaly / Q000209:etiology* / Q000473:pathology; D009043:Motor Activity / Q000502:physiology; D009186:Myelin Sheath / Q000502:physiology*; D009457:Neuroglia / Q000166:cytology