[Postradiation recovery of hemopoietic and stromal precursor cells in mice preinjected with prodigiozan].
Injection of prodigiozan to mice 24 h before irradiation caused, by the time of the radiation effect, a decrease in the number of haemopoietic cells-precursors (CFUs and CFU-HM) in the bone marrow and an increase in the functional activity of stromal cell-precursors--the haemopoietic microenvironment of transfer units (HMTU); in the spleen, the number of CFUs decreased, but the number of CFU-HM increased considerably. During the postirradiation period, the haemopoietic and stromal precursors were damaged to a lesser extent, and CFUs, CFU-HM and HMTU recovered more readily in prodigiozan-protected animals than in unprotected mice; the HMTU restoration preceded the increase in CFUs and CFU-HM levels.
Moroz
B B
BB
Lebedev
V G
VG
Romashko
O O
OO
Levina
N A
NA
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects; D003114:Colony-Forming Units Assay; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000528:radiation effects*; D008297:Male; D051379:Mice; D011354:Prodigiozan / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects / Q000528:radiation effects; D017154:Stromal Cells / Q000187:drug effects* / Q000528:radiation effects*; D013997:Time Factors
D011837:Radiation-Protective Agents; D011354:Prodigiozan
Postradiatsionnoe vosstanovlenie gemopoéticheskikh i stromal'nykh kletok-predshestvennikov u mysheĭ v usloviiakh predvaritel'nogo vvedeniia prodigiozana.