Effect of dothiepin on nociceptive response in diabetic rats.
In alloxan-diabetic rats of 4 wk duration with blood glucose levels of about 300 mg/100 ml, the tail flick reaction time (TFRT) to thermal stimuli was significantly elevated (P less than 0.25), indicating hypoalgesia. Intraperitoneal dothiepin, injections of 25 mg & 50 mg/kg body weight per day did not significantly alter the TFRT, either in control or in diabetic rats, following either acute (one dose), or short term (once a day for five days) administration. It is concluded that at least in the dosage schedule used herein, dothiepin does not influence hypoalgesia of diabetic neuropathy.
Rani
M A
MA
Department of Pharmacology, St. John's Medical College, Bangalore.
Andrade
C
C
David
J
J
D000704:Analysis of Variance; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology; D003929:Diabetic Neuropathies / Q000503:physiopathology*; D004308:Dothiepin / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D010146:Pain / Q000503:physiopathology*; D010147:Pain Measurement; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D004308:Dothiepin