Isolation and structure determination of new macrolide antibiotics.
Three new bafilomycin-like compounds PD 118,576-A1 [1], PD 118,576-A2 [2], and PD 118,576-A3 [3] were isolated from a new soil Streptomyces species (WP 3913). The structures of PD 118,576-A1, PD 118,576-A2, and PD 118,576-A3 were elucidated on the basis of spectroscopic studies including 2D nmr.
Hatfield
G M
GM
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Michigan, Ann Arbor 48109-1065.
Woodard
R W
RW
Son
J K
JK
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013302:Streptomyces / Q000737:chemistry / Q000378:metabolism*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D018942:Macrolides; C076596:PD 118576-A1; C076598:PD 118576-A2; C076599:PD 118576-A3