Induction of intestinal lesions in rabbits with Koyan and Baling strains of Schistosoma malayensis Sp N.
Schistosoma malayensis Sp N is a putative new species of schistosome discovered in Peninsular Malaysia in 1973. This paper comprises the first report on the detailed gastrointestinal pathology present in rabbits infected with strains of the parasite. Two different strains of schistosome--the Baling and Koyan strains--from two different ecosystems were used to infect inbred rabbits and the resulting pathophysiology was studied. Our results showed that the Baling strain of S. malayensis was more virulent than the Koyan strain and produced nodular, segmental circumferential lesions and large bilharziomas measuring 1-7 cm in diameter in the distal jejunum, ileum and the ileo-caecal junction. The findings indicate that the Baling strain of S. malayensis was more pathogenic for rabbits as compared with the Koyan strain--in relation to the gross pathology of the gut and the tissue egg load. Earlier reports have shown that rabbits infected with S. japonicum induces significant intestinal lesions in rabbits (Cheever et al, 1980 a,b) but these animals are refractory to infection with S. mekongi (Byram and Lichtenberg, 1980). Our studies show that the two strains of S. malayensis adapted well in rabbits. It is also established that in rabbits, the virulence of the Baling strain of S. malayensis is greater than that of S. mekongi and approximates that of S. japonicum.
Shekhar
K C
KC
Department of Parasitology and Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Pathmanathan
R
R
D000818:Animals; D004195:Disease Models, Animal; D005069:Evaluation Studies as Topic; D005260:Female; D006400:Hematocrit; D007411:Intestinal Diseases, Parasitic / Q000473:pathology*; D008099:Liver / Q000469:parasitology / Q000473:pathology; D008296:Malaysia; D009929:Organ Size; D010270:Parasite Egg Count; D011817:Rabbits; D012547:Schistosoma / Q000145:classification* / Q000472:pathogenicity; D012552:Schistosomiasis / Q000097:blood / Q000469:parasitology / Q000473:pathology*; D013154:Spleen / Q000473:pathology