title: Totally synthetic analogues of siastatin B. I. Optically active 2-acetamidopiperidine derivatives.
abstract: Totally synthetic analogues of siastatin B, optically active 2-acetamido-3,4,5-trihydroxypiperidines having the nitromethyl, aminomethyl and carboxyl branched groups at C-5 have been obtained from D-ribono-1,4-lactone by a stereospecific convergent method. Some analogues showed inhibitory activity against some glycosidases.
authors.affiliation: Institute of Microbial Chemistry, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kudo
authors.forename: Y
authors.initials: Y
authors.lastname: Nishimura
authors.forename: S
authors.initials: S
authors.lastname: Kondo
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D010880:Piperidines
chemical_list: D000900:Anti-Bacterial Agents; D010880:Piperidines; C011353:siastatin; D006026:Glycoside Hydrolases; D009439:Neuraminidase