TA-3037A, a new inhibitor of glutathione S-transferase, produced by actinomycetes. I. Production, isolation, physico-chemical properties and biological activities.
TA-3037A, a new inhibitor of glutathione S-transferase was discovered in the fermentation broth of Streptomyces sp. TA-3037. It was purified by chromatography followed by solvent extraction and then isolated as yellow needles. TA-3037A has the molecular formula of C16H11NO4. It was competitive with the substrate, and the inhibition constant (Ki) was 4.9 microM.
Komagata
D
D
Institute of Microbial Chemistry, Tokyo, Japan.
Sawa
T
T
Muraoka
Y
Y
Imada
C
C
Okami
Y
Y
Takeuchi
T
T
D002478:Cells, Cultured; D005285:Fermentation; D005982:Glutathione Transferase / Q000032:analysis / Q000037:antagonists & inhibitors*; D010078:Oxazines / Q000302:isolation & purification* / Q000493:pharmacokinetics; D013053:Spectrophotometry; D013302:Streptomyces / Q000145:classification / Q000378:metabolism
D010078:Oxazines; C076479:TA 3037A; D005982:Glutathione Transferase