[Mode of action of non-narcotic analgesics].
According to Lim's experiments, non-narcotic analgesics are usually considered as "peripherally" acting drugs. Conversely, most of these compounds were shown to easily cross the blood-brain barrier, and hence partly produce their effects by a central mechanism. The relative contribution of each site of action may vary from one drug to another. Aspirin-like drugs may act by inhibiting arachidonate cyclooxygenase in both the damaged tissues and the central nervous system. Finally, these drugs appear to be either selective, or dose-dependent, or nonspecific inhibitors of prostaglandin-synthetases.
Bannwarth
B
B
Centre de Pharmacologie, CHR Pellegrin, Bordeaux.
Chaslerie
A
A
Schaeverbeke
T
T
Vinçon
G
G
Dehais
J
J
Begaud
B
B
D000700:Analgesics / Q000145:classification / Q000494:pharmacology*; D000818:Animals; D006801:Humans; D011453:Prostaglandins / Q000096:biosynthesis
D000700:Analgesics; D011453:Prostaglandins
Modes d'action des antalgiques non morphiniques.