title: Unilateral voluntary hand movement and regional cerebral uptake of technetium-99m-exametazime in human control subjects.
abstract: The study examines the sensitivity of a region of interest approach to detect functional changes in brain metabolism with SPECT and split-dose 99mTc-exametazime by replicating a simple hand movement experiment previously carried out with PET. Regional uptake of 99mTc-exametazime was determined in 12 healthy controls before and during a thumb-digit opposition task. Analysis of regional uptake was carried out blind to the hand used in the opposition task and showed a significant unilateral activation effect in a pericentral region of interest with opposite results in left- and right-handed activation. The maximum contralateral increase in tracer uptake was 16% before and 26% after correction for back diffusion. This is in good agreement with previous results employing absolute cerebral blood flow determination with PET and confirms the usefulness of 99mTc-exametazime SPECT for the examination of functional metabolic changes.
authors.affiliation: MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Morningside Park, Scotland.
authors.forename: K P
authors.initials: KP
authors.lastname: Ebmeier
authors.forename: C L
authors.initials: CL
authors.lastname: Murray
authors.forename: N J
authors.initials: NJ
authors.lastname: Dougall
authors.forename: R E
authors.initials: RE
authors.lastname: O'Carroll
authors.forename: G M
authors.initials: GM
authors.lastname: Goodwin
mesh_terms: D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D002560:Cerebrovascular Circulation; D005260:Female; D006225:Hand / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D010091:Oximes / Q000493:pharmacokinetics*; D019690:Technetium Tc 99m Exametazime; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime