Synthesis and antimicrobial and anti-inflammatory activities of substituted 2-mercapto-3-(N-aryl)pyrimido[5,4-c]cinnolin-4-(3H)-ones.
Ten new substituted 2-mercapto-3-(N-aryl)pyrimido[5,4-c]cinnolin-4- (3H)-ones (4) were prepared by refluxing substituted 4-aminocinnolin-3-carboxylic acid (3) with substituted arylisothiocyanate in anhydrous pyridine. These derivatives were evaluated for their antimicrobial and anti-inflammatory activities. Some of the title compounds possess potent antimicrobial activity.
Nargund
L V
LV
Department of Pharmaceutical Chemistry, College of Pharmacy, J. N. Medical College, Belgaum, India.
Badiger
V V
VV
Yarnal
S M
SM
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D008297:Male; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011724:Pyridazines; D011743:Pyrimidines; D002351:Carrageenan