An unusual complication in a gravida with factor IX deficiency: case report with review of the literature.
Factor IX deficiency (hemophilia B, Christmas disease) is an X-linked recessive coagulation disorder. It occurs in one out of every 25,000-30,000 male births and requires even rarer genetic circumstances for phenotypic expression in females. We report the occurrence of a large, late-trimester subchorionic hematoma in a gravida with factor IX deficiency and with laboratory evidence of consumptive coagulopathy during treatment. The patient was managed conservatively and had a successful outcome at term. The only four reported cases of antepartum management of factor IX deficiency in the English literature are reviewed.
Guy
G P
GP
Department of Obstetrics and Gynecology, Columbia Presbyterian Medical Center, College of Physicians and Surgeons, Columbia University, New York, New York.
Baxi
L V
LV
Hurlet-Jensen
A
A
Chao
C R
CR
D000293:Adolescent; D002823:Chorion; D004211:Disseminated Intravascular Coagulation / Q000235:genetics / Q000628:therapy; D005260:Female; D006406:Hematoma / Q000209:etiology; D002836:Hemophilia B / Q000453:epidemiology* / Q000235:genetics / Q000628:therapy; D006801:Humans; D010375:Pedigree; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000453:epidemiology* / Q000628:therapy