Treatment of cerebral aspergillosis after liver transplantation.
We report the treatment of cerebral aspergillosis with amphotericin B, flucytosine, surgery, and liposomal amphotericin B (L-AmB) after a liver transplant. The patient died 2 months after cessation of antifungal therapy, as a consequence of multiple-system organ failure. The only relevant postmortem finding in the brain was a small, encapsulated abscess containing hyphae. This case indicates that L-AmB is an effective alternative drug for cerebral aspergillosis.
Polo
J M
JM
Service of Neurology, University Hospital Marqués de Valdecilla, University of Cantabria, Santander, Spain.
Fábrega
E
E
Casafont
F
F
Fariñas
M C
MC
Salesa
R
R
Vázquez
A
A
Berciano
J
J
D000666:Amphotericin B / Q000627:therapeutic use; D001228:Aspergillosis / Q000209:etiology / Q000628:therapy*; D001232:Aspergillus fumigatus / Q000302:isolation & purification; D001927:Brain Diseases / Q000382:microbiology / Q000628:therapy*; D003131:Combined Modality Therapy; D005437:Flucytosine / Q000627:therapeutic use; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000628:therapy*
D000666:Amphotericin B; D005437:Flucytosine