title: The future role of hepatic portoenterostomy as treatment of biliary atresia.
abstract: According to our recent study, 38 of 93 patients (40.9%) who underwent portoenterostomy at Juntendo University Hospital between 1977 and 1986 survived for more than 5 years. In order to learn the future improvement of the prognosis of biliary atresia patients who undergo portoenterostomy, we investigated the relationship between the prognosis of biliary atresia patients and the age and the histological changes of liver at the time of surgery. Twenty-seven of 30 patients (90%) who survived for more than 5 years with no jaundice and no findings of liver cirrhosis had a mild degree of liver fibrosis (F1 or F2) and a mild degree of degeneration of intrahepatic bile ducts (B1 or B2) at the time of surgery, in spite of the difference of size of intrahepatic bile ducts at the porta hepatis. On the other hand, all 8 patients who showed severe liver fibrosis (F3) and severe degeneration of intrahepatic bile ducts (B3) did not survive for more than 5 years. Accordingly, we can expect promising prognoses in patients who undergo refined portoenterostomy procedures and receive proper postoperative treatment before they have severe histological changes of liver. The portoenterostomy will still play an important role as treatment of biliary atresia in the future.
authors.affiliation: Katsunan Municipal Hospital, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Suruga
authors.forename: S
authors.initials: S
authors.lastname: Tsunoda
authors.forename: E
authors.initials: E
authors.lastname: Deguchi
authors.forename: K
authors.initials: K
authors.lastname: Kimura
authors.forename: T
authors.initials: T
authors.lastname: Miyano
mesh_terms: D001653:Bile Ducts, Intrahepatic / Q000473:pathology; D001656:Biliary Atresia / Q000150:complications / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008103:Liver Cirrhosis / Q000209:etiology / Q000473:pathology; D011171:Portoenterostomy, Hepatic; D011379:Prognosis