Effect of Ha-ras on mitogen-induced Ca(2+)- and K(+)-fluxes.
Transforming Ha-ras enhances the mitogen-induced activation of both the Ca(2+)-influx and the furosemide-sensitive Na+/K+/2Cl-cotransporter. Both systems represent essential early steps of mitogenic signal transduction in NIH 3T3 fibroblasts.
Grunicke
H
H
Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Austria.
Maly
K
K
Meyer
M
M
Oberhuber
H
H
Bichler
I
I
Waldegger
L S
LS
Woell
E
E
Lang
F
F
D016475:3T3 Cells; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D001839:Bombesin / Q000494:pharmacology; D001920:Bradykinin / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D002455:Cell Division / Q000187:drug effects; D005347:Fibroblasts; D005665:Furosemide / Q000494:pharmacology; D051379:Mice; D008934:Mitogens / Q000494:pharmacology*; D015689:Oncogene Protein p21(ras) / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism*; D012413:Rubidium / Q000378:metabolism; D014162:Transfection
D008934:Mitogens; D005665:Furosemide; D015689:Oncogene Protein p21(ras); D012413:Rubidium; D001839:Bombesin; D011188:Potassium; D001920:Bradykinin; D002118:Calcium