Mesenteric mast cell degranulation in acute T-2 toxin poisoning.
T-2 toxin-induced alterations in rat mesenteric mast cell granulation were measured by cytophotometric analyses of the metachromatic reaction of mast cell granules with azure B. Hypogranulation (diminution of metachromatic material) was observed 8 h following injections of T-2 toxin (0.5-1.5 LD50, i.p.). These data suggest that mast cell activation occurs during acute T-2 intoxication and raise the possibility that mast cell mediators may contribute to toxin-induced cardiovascular collapse.
Doebler
J A
JA
Neurotoxicology Branch, U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground-Edgewood Area, MD 21010.
Martin
L J
LJ
Morse
J D
JD
Ballough
G P
GP
Strauss
J A
JA
Anthony
A
A
D000818:Animals; D002412:Cations; D015550:Cell Degranulation / Q000187:drug effects*; D004396:Coloring Agents; D003592:Cytophotometry; D004305:Dose-Response Relationship, Drug; D006493:Heparin / Q000378:metabolism; D007928:Lethal Dose 50; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013605:T-2 Toxin / Q000506:poisoning* / Q000633:toxicity; D013997:Time Factors
D002412:Cations; D004396:Coloring Agents; D006493:Heparin; D013605:T-2 Toxin