title: Cutaneous vascular neoplasia in 15 cats: clinical, morphologic, and immunohistochemical studies.
abstract: Seven cases of cutaneous hemangioma and nine of cutaneous hemangiosarcoma were diagnosed from biopsy specimens of 15 Domestic Shorthairs of 5,091 cats that were examined by necropsy or biopsy during the 5-year period from 1 January 1986 through 31 December 1990. All but three cats were male. Tumor cells of both hemangiomas and hemangiosarcomas were immunoreactive for factor VIII-related antigen and for vimentin by the avidin biotin peroxidase complex method. In cats with a median age of 10 years, hemangiomas occurred in skin with pigmented hair in six of seven cases without apparent site predilection. These solitary tumors did not recur after excision although one cat (No. 3) subsequently developed cutaneous hemangiosarcoma at another site. Seven of nine hemangiosarcomas occurred in dermis and subcutis of the head, usually on the pinna. All five hemangiosarcomas of the head, for which cutaneous pigmentation could be determined, occurred in unpigmented skin. Cats with hemangiosarcoma had a median age of 12.5 years at the time of diagnosis. Metastasis has not been documented, but hemangiosarcoma has recurred, from 1 month to 2 years after excision, in 6/7 cats that were studied.
authors.affiliation: Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri, Columbia.
authors.forename: M A
authors.initials: MA
authors.lastname: Miller
authors.forename: J A
authors.initials: JA
authors.lastname: Ramos
authors.forename: J M
authors.initials: JM
authors.lastname: Kreeger
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D004431:Ear, External; D005260:Female; D006257:Head; D006391:Hemangioma / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D006392:Hemangioma, Cavernous / Q000737:chemistry / Q000473:pathology / Q000662:veterinary; D006394:Hemangiosarcoma / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry; D008297:Male; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D012880:Skin Pigmentation; D014746:Vimentin / Q000032:analysis; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D014746:Vimentin; D014841:von Willebrand Factor