title: The study of properties of immunoreactive estradiol secreted by adrenals and ovaries of immature female rats.
abstract: Some properties of immunoreactive estradiol secreted by adrenals and ovaries of immature female rats were studied. It was shown that adrenals and ovaries of 15-day-old animals secrete approximately equal amounts of immunoreactive estradiol, with thin-layer chromatogram of immunoreactive material being identical for both glands. Adrenal- as well as ovarian-derived estradiol can bind to uterine cytosol estradiol receptors with the formation of complexes, which can be activated in the cell-free system. The removal of either adrenals or ovaries causes a decrease of cytosol estradiol receptor levels in the uterus 6 hours after the operation. From these results and previously reported data, nothing suggests that immunoreactive estradiol secreted by the adrenals of immature rats should be regarded as "spurious" hormone.
authors.affiliation: Department of Physiological Genetics, Institute of Cytology and Genetics, Novosibirsk, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Tinnikov
authors.forename: N M
authors.initials: NM
authors.lastname: Bazhan
authors.forename: T V
authors.initials: TV
authors.lastname: Yakovleva
mesh_terms: D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D002855:Chromatography, Thin Layer; D003600:Cytosol / Q000737:chemistry / Q000378:metabolism; D004958:Estradiol / Q000737:chemistry / Q000378:metabolism*; D005260:Female; D010053:Ovary / Q000378:metabolism*; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains; D011959:Receptors, Estradiol / Q000378:metabolism*; D014599:Uterus / Q000378:metabolism
chemical_list: D011959:Receptors, Estradiol; D004958:Estradiol