Heterophyids: experimental chemotherapy and immunotherapy.
Heavy infections with the tiny flukes heterophyids can cause intestinal pain and mucous diarrhea, thus the study of praziquantel (Pzq) and the new drug cyclosporin A (CsA) as antiparasitic drugs were undertaken in this work, as well as the effect of matecercarial and adult antigens as immunizing agents. To assess the result of our work, the number and length of the recovered heterophyids were studied. Description of the surface by SEM was carried out for the groups: treated by cyclosporin A and immunized by adult heterophyid antigen (third fraction) which gave the highest percentage reduction.
el-Azzouni
M Z
MZ
Department of Parasitology, Faculty of Medicine, Alexandria University, Egypt.
Boulos
L M
LM
D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology*; D016572:Cyclosporine / Q000627:therapeutic use*; D006578:Heterophyidae / Q000187:drug effects / Q000276:immunology*; D007114:Immunization; D051379:Mice; D011223:Praziquantel / Q000627:therapeutic use*; D014201:Trematode Infections / Q000188:drug therapy* / Q000517:prevention & control
D000947:Antigens, Helminth; D011223:Praziquantel; D016572:Cyclosporine