[Clinical efficacy of ceftriaxone when administered once daily for respiratory tract infections in patients with advanced ages].
Ceftriaxone (CTRX), a new third generation cephalosporin, was investigated upon once daily administration for its clinical efficacy and safety on respiratory tract infections in patients with advanced ages. The results are summarized as follows: 1. Clinical responses to CTRX of 48 cases of advanced age patients with respiratory tract infections were good with an efficacy rate of 89.6%. 2. Adverse reactions to CTRX were mainly exanthema in 7 cases (14.6%). 3. Serum levels of CTRX were determined in 4 cases after intravenous drip infusion of 2 g CTRX. Serum levels were analyzed by one-compartment model. There was no evidence of accumulation of CTRX in the patients with advanced ages.
Takizawa
S
S
Department of Respiratory Medicine, Seirei Mikatahara General Hospital.
Yanase
K
K
Hashizume
I
I
Kasamatsu
N
N
Tachibana
A
A
Ogisu
N
N
Okazawa
M
M
D000368:Aged; D000369:Aged, 80 and over; D002443:Ceftriaxone / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood; D005076:Exanthema / Q000139:chemically induced; D005260:Female; D006801:Humans; D008297:Male; D012141:Respiratory Tract Infections / Q000188:drug therapy*
D002443:Ceftriaxone