Enhancement of lymphocyte proliferation by mouse glandular kallikrein.
Mouse glandular kallikrein (mGK) strongly enhanced the spontaneous and mitogen-induced proliferation of lymphocytes. Both blast formation and 3H-TdR incorporation were dose-dependently enhanced at the same time many cells were killed. The enhancing activity was independent of EGF, because EGF-binding proteins (mGK-9 in mGK-6,9 mixture and mGK-13), renal kallikrein (mGK-6) and human kallikrein all displayed the same enhancement. A serine proteinase inhibitor, diisopropyl fluorophosphate, could block the enhancement by mGK. The new function suggests that mGK is important in the immune system as a regulatory molecule.
Hu
Z Q
ZQ
Department of Microbiology and Immunology, Showa University School of Medicine, Tokyo, Japan.
Murakami
K
K
Ikigai
H
H
Shimamura
T
T
D000818:Animals; D005260:Female; D006801:Humans; D007610:Kallikreins / Q000037:antagonists & inhibitors / Q000145:classification / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D008934:Mitogens / Q000494:pharmacology; D013268:Stimulation, Chemical
D008934:Mitogens; D007610:Kallikreins