Calcium-channel blocking agents as therapy for amphotericin B nephrotoxicity.
Amphotericin B is a broad-spectrum antifungal agent shown to be effective in the treatment of systemic fungal infections. Unfortunately, therapeutic doses are often associated with a variety of adverse effects, including nephrotoxicity. Studies of the deleterious effects of amphotericin B on the renal microvasculature are yielding clues to sparing kidney function. In selected patients, concomitant use of a calcium-channel blocker may prevent the nephrotoxic effects of amphotericin B and allow full therapeutic doses to be used.
Brouhard
B H
BH
Department of Pediatrics, Cleveland Clinic Foundation, OH 44195.
Baetz-Greenwalt
B
B
D000666:Amphotericin B / Q000009:adverse effects*; D000818:Animals; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000188:drug therapy* / Q000503:physiopathology
D002121:Calcium Channel Blockers; D000666:Amphotericin B