Pharmacokinetics and effects of atrial natriuretic factor during hypothermic cardiopulmonary bypass.
The pharmacokinetics of a bolus dose of synthetic atrial natriuretic factor (ANF) 50 micrograms and its effects on urine output, blood pressure and plasma renin activity have been studied in 5 patients undergoing hypothermic cardiopulmonary bypass for cardiac surgery. The half-lives of the fast and slow components were 2.4 min and 14.2 min, respectively. The volume of the central compartment was 16.7 l and the volume of distribution at steady-state was 38.9 l. The total plasma clearance was 3.8 l.min-1. ANF significantly increased urine output and decreased blood pressure, but it did not affect plasma renin activity.
Hynynen
M
M
Department of Anaesthesia, Helsinki University Central Hospital, Finland.
Olkkola
K T
KT
Palojoki
R
R
Tikkanen
I
I
Fyhrquist
F
F
D009320:Atrial Natriuretic Factor / Q000493:pharmacokinetics* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D006207:Half-Life; D006801:Humans; D007036:Hypothermia, Induced; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D012083:Renin / Q000097:blood; D014554:Urination / Q000187:drug effects
D009320:Atrial Natriuretic Factor; D012083:Renin