Effect of dietary nitrate on endogenous nitrosation of piperazine in humans.
The effect of dietary nitrate on endogenous nitrosation of a therapeutic dose of piperazine has been described in five human volunteers who acted as their own controls. The urinary excretion of endogenously formed N-nitro-somonopiperazine (MNPz) ranged between 9.2 and 80.1 micrograms/24 h on a normal uncontrolled diet which increased from 25.7 to 163.7 micrograms/24 h when the diet was supplemented with 250 mg nitrate. The corresponding urinary nitrate was 63.0-122.7 mg/24 h and 119.2-322.0 mg/24 h, respectively. The dinitroso derivative of piperazine was detected only in trace amounts and no detectable increase in its excretion was observed during high nitrate exposure. The unchanged piperazine (range 294-784 mg/24 h) in urine showed a decrease under high nitrate regimen (range 185-399 mg/24 h).
Kumar
R
R
Department of Pharmaceutical Sciences, University of Kashmir, India.
Siddiqi
M
M
Fazili
Z
Z
Wacker
C D
CD
Spiegelhalder
B
B
Preussmann
R
R
D002273:Carcinogens / Q000032:analysis*; D004032:Diet; D006801:Humans; D009566:Nitrates / Q000378:metabolism* / Q000652:urine; D009602:Nitrosamines / Q000652:urine*; D000077489:Piperazine; D010879:Piperazines / Q000378:metabolism* / Q000652:urine
D002273:Carcinogens; D009566:Nitrates; D009602:Nitrosamines; D010879:Piperazines; D000077489:Piperazine; C014711:1-nitrosopiperazine