Fraction of absorbed drug at the time of peak plasma concentration in an open one-compartment model after simultaneous oral and intravenous administration.
When a drug is simultaneously given orally and intravenously, the plasma concentration generally reaches a maximum. The purpose of this paper is to assess the extent of absorbed drug at the time Tmax.
Plusquellec
Y
Y
Unité de Formation et de Recherches de Mathématiques, Université Paul Sabtier, Toulouse, France.
Houin
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G
D000284:Administration, Oral; D006801:Humans; D007275:Injections, Intravenous; D008954:Models, Biological; D010599:Pharmacokinetics