title: A cocaine analog and a GBR analog label the same protein in rat striatal membranes.
abstract: Because some evidence suggests that cocaine and GBR12935 bind to different sites, we utilized photoaffinity probes from both classes of compounds to see if they label the same protein. [125I]RTI-82 a cocaine analog, and [125I]DEEP, a GBR analog, labeled protein(s) showing the same molecular weight, a similar pharmacological profile and a similar sensitivity to neuraminidase.
authors.affiliation: Neuroscience Branch, Addiction Research Center, National Institute on Drug Abuse, Baltimore, MD 21224.
authors.forename: A
authors.initials: A
authors.lastname: Patel
authors.forename: J W
authors.initials: JW
authors.lastname: Boja
authors.forename: J
authors.initials: J
authors.lastname: Lever
authors.forename: R
authors.initials: R
authors.lastname: Lew
authors.forename: R
authors.initials: R
authors.lastname: Simantov
authors.forename: F I
authors.initials: FI
authors.lastname: Carroll
authors.forename: A H
authors.initials: AH
authors.lastname: Lewin
authors.forename: A
authors.initials: A
authors.lastname: Philip
authors.forename: Y
authors.initials: Y
authors.lastname: Gao
authors.forename: M J
authors.initials: MJ
authors.lastname: Kuhar
mesh_terms: D000818:Animals; D001386:Azides / Q000378:metabolism / Q000494:pharmacology*; D001665:Binding Sites; D002352:Carrier Proteins / Q000302:isolation & purification / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D003042:Cocaine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D050483:Dopamine Plasma Membrane Transport Proteins; D004591:Electrophoresis, Polyacrylamide Gel; D007457:Iodine Radioisotopes; D008024:Ligands; D008562:Membrane Glycoproteins / Q000302:isolation & purification / Q000378:metabolism; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D010879:Piperazines / Q000378:metabolism*; D051381:Rats
chemical_list: D001386:Azides; D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D007457:Iodine Radioisotopes; D008024:Ligands; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D010879:Piperazines; C076379:RTI 82; C044630:1-(2 (diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine; D003042:Cocaine; D004298:Dopamine