Consecutive treatment of disulfiram inhibits ovarian carbonyl reductase activity in rats.
We investigated the effects of disulfiram (DS) on ovarian carbonyl reductase activity in rats to determine the influence of DS on female reproductive function. Three consecutive treatments with DS significantly inhibited ovarian carbonyl reductase activity as well as ovulation, dose-dependently. Single treatment with DS had no effect on ovarian carbonyl reductase activity. Our observations indicate that consecutive treatment with DS has an inhibitory action on female reproductive function, although DS is well-known to inhibit aldehyde dehydrogenase and dopamine beta-hydroxylase.
Iwata
N
N
Division of Xenobiotic Metabolism and Disposition, National Institute of Hygienic Sciences, Tokyo, Japan.
Inazu
N
N
Satoh
T
T
D000429:Alcohol Oxidoreductases / Q000032:analysis / Q000037:antagonists & inhibitors*; D000449:Aldehyde Reductase; D000074408:Aldo-Keto Reductases; D000818:Animals; D004221:Disulfiram / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D010053:Ovary / Q000201:enzymology*; D010060:Ovulation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D000429:Alcohol Oxidoreductases; D000074408:Aldo-Keto Reductases; D000449:Aldehyde Reductase; D004221:Disulfiram