Predictors of response to antidepressant medications.
In a 10-year interval, 175 residents of a state institution who had severe or profound mental retardation were treated with heterocyclic antidepressants when other medications and forms of treatment had proved ineffective. Responders to the medication were identified and compared with nonresponders to determine which presenting symptoms and other parameters might serve as predictors of medication efficacy.
Langee
H R
HR
University of Florida, Gainesville.
Conlon
M
M
D000374:Aggression / Q000187:drug effects / Q000523:psychology; D000639:Amitriptyline / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy / Q000523:psychology; D004316:Doxepin / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D007326:Institutionalization; D008607:Intellectual Disability / Q000188:drug therapy* / Q000523:psychology; D009043:Motor Activity / Q000187:drug effects; D011595:Psychomotor Agitation / Q000188:drug therapy / Q000523:psychology; D011618:Psychotic Disorders / Q000188:drug therapy / Q000523:psychology; D012189:Retrospective Studies; D016728:Self-Injurious Behavior / Q000188:drug therapy / Q000523:psychology
D000928:Antidepressive Agents; D004316:Doxepin; D000639:Amitriptyline