[In vitro evaluation of the activity of butoconazole against Trichomonas vaginalis].
An in vitro study was carried out on ten first clinical isolates of Trichomonas vaginalis. Increasing levels of butaconazole were added to 150 microliters of a dilution in Roiron medium adjusted to 50,000 Trichomonas/ml. Results were read after 1, 2, 6 and 24 hours aerobic incubation at 37 degrees C. Minimum lethal concentration was 93 micrograms/microliters after one hour, 23 micrograms/microliter after six hours and 12 micrograms/microliters after 24 hours. These findings warrant in vivo studies of butoconazole against Trichomonas. This drug, which has already been proved effective in fungal infections, may prove very useful since concomitant infection of the genital tract by Trichomonas and Candida is common.
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Laboratoire de Parasitologie, Hôpital Bicêtre, Kremlin-Bicêtre.
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D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007093:Imidazoles / Q000494:pharmacology*; D066298:In Vitro Techniques; D014246:Trichomonas vaginalis / Q000187:drug effects*
D000935:Antifungal Agents; D007093:Imidazoles; C017125:butoconazole
Evaluation in vitro de l'activité du butoconazole sur Trichomonas vaginalis.