title: Localization of estrogen receptors and estrogen receptor-mRNA in female mouse thymus.
abstract: The present study was performed to demonstrate estrogen receptor (ER) and ER-mRNA in female mouse thymus. The results are as follows: (i) thymic tissue contains ER in both reticuloepithelial(RE)- and T-cell fractions, the ER level being three-fold higher in the former fraction than in the latter; and (ii) thymic tissue contains ER-mRNA at 6.2 kb, a large amount of which was localized in the RE cells and less in the T cells. From these results it is suggested that estrogen (E) mediates some immune function of the mouse thymus through its receptor within RE cells and/or T cells.
authors.affiliation: Department of Morphology, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Kawashima
authors.forename: K
authors.initials: K
authors.lastname: Seiki
authors.forename: K
authors.initials: K
authors.lastname: Sakabe
authors.forename: S
authors.initials: S
authors.lastname: Ihara
authors.forename: A
authors.initials: A
authors.lastname: Akatsuka
authors.forename: Y
authors.initials: Y
authors.lastname: Katsumata
mesh_terms: D000818:Animals; D015152:Blotting, Northern; D005260:Female; D007124:Immunoenzyme Techniques; D051379:Mice; D008810:Mice, Inbred C57BL; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000032:analysis*; D011960:Receptors, Estrogen / Q000032:analysis* / Q000235:genetics; D013950:Thymus Gland / Q000737:chemistry*
chemical_list: D012333:RNA, Messenger; D011960:Receptors, Estrogen