[Antipyretic effects of traditional Chinese medicines in bacterial endotoxin-induced febrile rabbits].
The antipyretic effects of oral administration of eight traditional Chinese medicines (dried extracts) were tested in febrile rabbits injected with bacterial pyrogen, lipopolysaccharide (LPS) 0.05 micrograms/kg (i.v.). The traditional Chinese medicines were given 0.6-2 g/10 ml/kg (p.o.) simultaneously with LPS. The most potent antipyretic effect was observed in Dai-jyoki-to (Ta-chen-chi-tang). The moderate antipyretic effects were observed in Toki-syakuyaku-san (Tang-kuei-shao-yao-san) and Syo-saiko-to (Hssiao-chai-hu-tang). Koso-san (Hsiang-su-san), Oren-gedoku-to (Huang-lien-chieh-tu-tan), Gorei-san (Wu-ling-san), Kakkon-to (Ko-ken-tang) and Byakkoka-ninjin-to (Pai-hu-chia-jen-sheng-tang) showed no effects.
Itami
T
T
National Institute of Hygienic Sciences, Osaka Branch, Chuo-ku, Japan.
Ema
M
M
Sakamoto
J
J
Hosoda
K
K
Noguchi
M
M
Kawasaki
H
H
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005334:Fever / Q000139:chemically induced / Q000188:drug therapy*; D008070:Lipopolysaccharides; D008297:Male; D011817:Rabbits
D004365:Drugs, Chinese Herbal; D008070:Lipopolysaccharides