Effect of the cyanobacterial (blue-green algal) toxins from Microcystis aeruginosa on isolated enterocytes from the chicken small intestine.
Livestock deaths, and clinical reports of human injury, follow the consumption of toxic blue-green algae. The experiments described show that isolated intestinal enterocytes from chicks are both deformed and killed by exposure to Microcystis toxins, in a dose-dependent and time-dependent manner. The enterocytes were protected from toxicity by deoxycholate, bromosulphothalein and rifampicin. It was concluded that the gastroenteritis clinically associated with accidental Microcystis ingestion is likely to reflect enterocyte injury by Microcystis toxins, and that the therapeutic use of bile acids or transport inhibitors may be of value in treatment.
Falconer
I R
IR
Department of Biochemistry, Microbiology and Nutrition, University of New England, Armidale NSW, Australia.
Dornbusch
M
M
Moran
G
G
Yeung
S K
SK
D000818:Animals; D001647:Bile Acids and Salts / Q000494:pharmacology; D002645:Chickens; D066298:In Vitro Techniques; D007422:Intestines / Q000166:cytology / Q000187:drug effects*; D052998:Microcystins; D046931:Microcystis / Q000378:metabolism*; D010456:Peptides, Cyclic / Q000633:toxicity*
D001647:Bile Acids and Salts; D052998:Microcystins; D010456:Peptides, Cyclic; C068747:microcystin YM