Stereological studies of the parathyroid gland of phosphate-treated golden hamsters subjected to a hypergravity environment.
The ultrastructure of the parathyroid glands of phosphate-treated golden hamsters exposed to a 5-G environment was studied. In the phosphate-treated animals exposed to a hypergravity environment, the Golgi complexes associated with numerous prosecretory granules, and the enlarged intercellular spaces containing floccular or finely particulate material showed a significant increase compared to those of the control, centrifuged, and phosphate-treated groups, and the cisternae of the granular endoplasmic reticulum showed a significant increase compared to those of the control and phosphate-treated groups. In addition, numerous secretory granules were situated close to the plasma membrane of chief cells in the phosphate-treated animals exposed to a hypergravity environment. These findings suggest that the synthesis, and to a greater extent the release of secretory granules may be markedly stimulated, in the parathyroid glands of phosphate-treated animals exposed to a hypergravity environment.
Shoumura
S
S
Department of Anatomy, Gifu University School of Medicine, Japan.
Emura
S
S
Utsumi
M
M
Yamahira
T
T
Hayakawa
D
D
Terasawa
K
K
Tamada
A
A
Arakawa
M
M
Isono
H
H
D000818:Animals; D002118:Calcium / Q000097:blood; D006224:Cricetinae; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D006112:Gravitation; D008247:Lysosomes / Q000648:ultrastructure; D008297:Male; D008647:Mesocricetus; D008854:Microscopy, Electron; D010280:Parathyroid Glands / Q000187:drug effects / Q000648:ultrastructure*; D010710:Phosphates / Q000494:pharmacology*; D012016:Reference Values; D014617:Vacuoles / Q000648:ultrastructure
D010710:Phosphates; D002118:Calcium