Within-subject biological variation of hematological quantities and analytical goals.
For several common hematological quantities, the within-subject biological variation during a 1-year period was estimated in a group of 39 apparently healthy volunteers: 19 women and 20 men. All measurements were performed with a hematological analyzer (Toa E-5000, Toa Medical Electronics, Kobe, Japan). The means of the within-subject biological coefficients of variation, separated by sex when significant difference was shown, were as follows: 2.8% for hemoglobin concentration; 3.0% for erythrocyte concentration; 2.9% for erythrocyte volume fraction; 1.1% for mean erythrocyte volume; 1.9% for arbitrary SD of erythrocyte volume; 1.6% for mean erythrocyte hemoglobin concentration; 1.3% for mean erythrocyte hemoglobin; 10.8% in men and 15.7% in women for leukocyte concentration; and 6.7% in men and 8.6% in women for platelet concentration. The desirable between-day imprecisions for the measurement of each quantity were established as one half of the average of within-subject biological variation.
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Clinical Analysis Laboratory, Hospital de Viladecans, Spain.
Miró
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Fuentes-Arderiu
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D000328:Adult; D001772:Blood Cell Count; D004911:Erythrocyte Volume; D004912:Erythrocytes / Q000737:chemistry; D005260:Female; D006403:Hematologic Tests / Q000592:standards*; D006405:Hematology / Q000295:instrumentation / Q000379:methods*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007206:Individuality; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D015203:Reproducibility of Results; D013223:Statistics as Topic
D006454:Hemoglobins