Clonality in myeloproliferative disorders.
The myeloproliferative disorders are a group of hematologic diseases that are believed to arise from somatic mutations in an early hematopoietic stem cell. This statement is based on the demonstration of monoclonal involvement of terminally differentiated myeloid and lymphoid elements. The techniques for establishing clonal derivation of cells are discussed and the application of these techniques to myeloproliferative diseases is reviewed. The evidence for limited myeloid involvement, lineage heterogeneity, in some patients with myeloproliferative disorders is summarized.
Blanchard
K L
KL
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Gilliland
D G
DG
Bunn
H F
HF
D001772:Blood Cell Count; D006801:Humans; D009196:Myeloproliferative Disorders / Q000097:blood* / Q000235:genetics*; D011110:Polymorphism, Genetic; D014960:X Chromosome