title: Isolation of a gene required for programmed initiation of development by Aspergillus nidulans.
abstract: In contrast to many other cases in microbial development, Aspergillus nidulans conidiophore production initiates primarily as a programmed part of the life cycle rather than as a response to nutrient deprivation. Mutations in the acoD locus result in "fluffy" colonies that appear to grow faster than the wild type and proliferate as undifferentiated masses of vegetative cells. We show that unlike wild-type strains, acoD deletion mutants are unable to make conidiophores under optimal growth conditions but can be induced to conidiate when growth is nutritionally limited. The requirement for acoD in conidiophore development occurs prior to activation of brlA, a primary regulator of development. The acoD transcript is present both in vegetative hyphae prior to developmental induction and in developing cultures. However, the effects of acoD mutations are detectable only after developmental induction. We propose that acoD activity is primarily controlled at the posttranscriptional level and that it is required to direct developmentally specific changes that bring about growth inhibition and activation of brlA expression to result in conidiophore development.
authors.affiliation: Department of Biology, Texas A&M University, College Station 77843.
authors.forename: T H
authors.initials: TH
authors.lastname: Adams
authors.forename: W A
authors.initials: WA
authors.lastname: Hide
authors.forename: L N
authors.initials: LN
authors.lastname: Yager
authors.forename: B N
authors.initials: BN
authors.lastname: Lee
mesh_terms: D001233:Aspergillus nidulans / Q000235:genetics* / Q000254:growth & development; D005656:Fungal Proteins / Q000235:genetics; D015966:Gene Expression Regulation, Fungal; D005800:Genes, Fungal; D007700:Kinetics; D009154:Mutation; D010641:Phenotype; D015183:Restriction Mapping; D014157:Transcription Factors
chemical_list: C063497:BRLA protein, Emericella nidulans; D005656:Fungal Proteins; D014157:Transcription Factors