title: Direct measurement of spin-lattice relaxation times of phosphorus metabolites in human myocardium.
abstract: T1 values of phosphorus metabolites visible in human cardiac 31P-MR spectra were determined in 12 volunteers at 1.5 T. Consecutive spectra were acquired with varying pulse repetition time (TR) from 1.6 to 24 s; volume selection was achieved with ISIS. T1's of creatine phosphate (CP), [gamma-P], [alpha-P], and [beta-P]ATP, 2-3 diphosphoglycerate, and phosphodiesters were 6.1 +/- 0.5, 5.4 +/- 0.5, 5.5 +/- 0.5, 5.8 +/- 1.0, 7.6 +/- 1.0, and 5.0 +/- 1.0 s, respectively. CP/ATP ratios showed little change with varying TR; linear regression of CP/ATP vs TR was of borderline significance (r = 0.28, P = 0.06). T1's for CP and ATP were also determined in standard solution (20 mM CP, 10 mM ATP) yielding T1CP of 8.7 +/- 0.2 and T1[gamma-P]-ATP of 9.9 +/- 0.7 s. Thus, T1's for CP and ATP were similar at 1.5 T in both human heart and standard solution. In human cardiac 31P-MR spectra, CP/ATP ratios may need little correction for partial saturation.
authors.affiliation: Department of Medicine, University of Würzburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Neubauer
authors.forename: T
authors.initials: T
authors.lastname: Krahe
authors.forename: R
authors.initials: R
authors.lastname: Schindler
authors.forename: H
authors.initials: H
authors.lastname: Hillenbrand
authors.forename: C
authors.initials: C
authors.lastname: Entzeroth
authors.forename: M
authors.initials: M
authors.lastname: Horn
authors.forename: W R
authors.initials: WR
authors.lastname: Bauer
authors.forename: T
authors.initials: T
authors.lastname: Stephan
authors.forename: K
authors.initials: K
authors.lastname: Lackner
authors.forename: A
authors.initials: A
authors.lastname: Haase
mesh_terms: D019794:2,3-Diphosphoglycerate; D000255:Adenosine Triphosphate / Q000032:analysis; D000328:Adult; D004163:Diphosphoglyceric Acids / Q000032:analysis; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009206:Myocardium / Q000737:chemistry*; D010725:Phosphocreatine / Q000032:analysis; D010758:Phosphorus / Q000032:analysis / Q000378:metabolism*; D013997:Time Factors
chemical_list: D004163:Diphosphoglyceric Acids; D010725:Phosphocreatine; D019794:2,3-Diphosphoglycerate; D010758:Phosphorus; D000255:Adenosine Triphosphate