[Dose-finding study for hyperfractionated, accelerated radiotherapy plus simultaneous carboplatin administration in patients with locoregionally advanced head and neck cancer].
Therapy of large inoperable squamous cell-carcinomas of the head and neck is considerably problemful. Combined simultaneous radio-chemotherapy with carboplatin and radiotherapy with hyperfractionated accelerated radiation is small effective than conventional monofractionated radiotherapy alone and may reduce side effects. Aim of the following study was dosage optimisation of the applicated carboplatin.
Kehrl
W
W
HNO-Klinik, Universitäts-Krankenhauses Hamburg-Eppendorf.
Brockmann
W P
WP
Zschaber
R
R
Hartwein
J
J
D016190:Carboplatin / Q000009:adverse effects / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D006801:Humans; D010039:Otorhinolaryngologic Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy
D016190:Carboplatin
Dosisfindungsstudie zur hyperfraktionierten, akzelerierten Strahlentherapie plus simultaner Carboplatin-Gabe bei Patienten mit lokoregionär fortgeschrittenen Kopf-Hals-Karzinomen.