title: Treatment of persistent epithelial defects in neurotrophic keratitis with epidermal growth factor: a preliminary open study.
abstract: We report three patients with persistent epithelial defects in the context of neurotrophic keratopathy that healed while on treatment with topically applied, mouse-derived epidermal growth factor (m-EGF). The clinical course of these patients was striking and suggests that EGF may have a potential role in the treatment of persistent epithelial defects in subjects suffering from neurotrophic keratitis.
authors.affiliation: Institute of Ophthalmology, School of Medicine, University of Perugia, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Daniele
authors.forename: J P
authors.initials: JP
authors.lastname: Gilbard
authors.forename: C L
authors.initials: CL
authors.lastname: Schepens
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D003315:Cornea / Q000294:innervation*; D004815:Epidermal Growth Factor / Q000008:administration & dosage / Q000627:therapeutic use*; D004848:Epithelium / Q000187:drug effects; D015590:Fluorophotometry; D006801:Humans; D007634:Keratitis / Q000628:therapy*; D008297:Male; D009422:Nervous System Diseases / Q000188:drug therapy; D010865:Pilot Projects
chemical_list: D004815:Epidermal Growth Factor