title: Abnormal left ventricular filling pattern in patients with single vessel coronary artery disease: effect of angioplasty.
abstract: To study the effect of coronary angioplasty (PTCA) on left ventricular (LV) diastolic filling, mitral Doppler flow tracings of 15 patients with isolated stenosis of the left anterior descending coronary artery (LAD) and normal systolic LV function were recorded before PTCA as well as 24 h and 3 months after successful PTCA. Compared to control subjects, patients with LAD stenosis exhibited an abnormal LV filling velocity pattern before PTCA. The day following PTCA, the ratios of the early peak diastolic velocity to the peak late diastolic velocity and of the time velocity integral of the early diastolic filling phase to the time velocity integral of the late diastolic filling phase were unchanged. Despite the absence of clinical evidence of restenosis, LV filling remained abnormal 3 months after PTCA. The results suggest that abnormalities of the LV filling velocity in patients with isolated LAD stenosis and normal systolic function may persist as long as 3 months after PTCA.
authors.affiliation: Cardiology Center, University Hospital, Geneva, Switzerland.
authors.forename: F
authors.initials: F
authors.lastname: Ricou
authors.forename: R
authors.initials: R
authors.lastname: Lerch
authors.forename: B
authors.initials: B
authors.lastname: Meier
authors.forename: W
authors.initials: W
authors.lastname: Rutishauser
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D001783:Blood Flow Velocity / Q000502:physiology; D003326:Coronary Circulation / Q000502:physiology*; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D015150:Echocardiography, Doppler; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology; D013997:Time Factors; D016277:Ventricular Function, Left / Q000502:physiology*