31P NMR spectroscopy of the human heart at 4 T: detection of substantially uncontaminated cardiac spectra and differentiation of subepicardium and subendocardium.
31P NMR spectroscopy of the human heart was undertaken at 4 T to investigate whether spectra localized exclusively to the myocardium can be obtained. Utilizing a Fourier series window approach to spectroscopic imaging, we find that at least two layers across the anterior left ventricle wall can be detected, with voxel sizes of about 8 cm3.
Menon
R S
RS
Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis 55455.
Hendrich
K
K
Hu
X
X
Uğurbil
K
K
D019794:2,3-Diphosphoglycerate; D000255:Adenosine Triphosphate / Q000032:analysis; D000328:Adult; D004163:Diphosphoglyceric Acids / Q000032:analysis / Q000097:blood; D004699:Endocardium / Q000378:metabolism*; D005583:Fourier Analysis; D006352:Heart Ventricles / Q000378:metabolism; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010496:Pericardium / Q000378:metabolism*; D010710:Phosphates / Q000032:analysis; D010725:Phosphocreatine / Q000032:analysis; D010758:Phosphorus
D004163:Diphosphoglyceric Acids; D010710:Phosphates; D010725:Phosphocreatine; D019794:2,3-Diphosphoglycerate; D010758:Phosphorus; D000255:Adenosine Triphosphate