title: Cloning of a cDNA encoding a receptor related to the formyl peptide receptor of human neutrophils.
abstract: We cloned a cDNA (RFP) encoding a receptor (RFP) related (70% overall nucleotide homology) to the formyl peptide receptor of human neutrophils (hFPR). RFP is a seven-transmembrane-domain receptor and its distribution is limited to myeloid cells. Domain sequence comparison with hFPR reveals highly conserved regions and provides clues to putative domains involved in ligand binding and receptor desensitization.
authors.affiliation: Department of Medicine, University of California, San Francisco 94143.
authors.forename: H D
authors.initials: HD
authors.lastname: Perez
authors.forename: R
authors.initials: R
authors.lastname: Holmes
authors.forename: E
authors.initials: E
authors.lastname: Kelly
authors.forename: J
authors.initials: J
authors.lastname: McClary
authors.forename: W H
authors.initials: WH
authors.lastname: Andrews
mesh_terms: D000595:Amino Acid Sequence; D002460:Cell Line; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000378:metabolism*; D009504:Neutrophils / Q000378:metabolism*; D044042:Receptors, Formyl Peptide; D011971:Receptors, Immunologic / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D012689:Sequence Homology, Nucleic Acid
chemical_list: D044042:Receptors, Formyl Peptide; D011971:Receptors, Immunologic; D009240:N-Formylmethionine Leucyl-Phenylalanine; D004247:DNA