[Toxicity of dichloropropanols--changes in hematological findings and serum chemistry].
We investigated the toxicity of dichloropropanols (DCPs) in hematological findings and serum chemistry. The solutions of two isomers of DCPs, 1,3-dichloro-2-propanol (DC2P) and 2,3-dichloro-1-propanol (DC1P) were dissolved in saline at the concentration of 100 mg/ml, and 0.1 ml of each solution was subcutaneously injected into male Wistar rats weighing about 200 g. At 6 hours after the injections, in the DC2P group, the number of white blood cells and platelets showed a significant decrease. Transaminases, alkaline phosphatase and lactate dehydrogenase were greatly elevated. Blood urea nitrogen and creatinine also showed a significant increase. There were no changes in the measurements in the DC1P group. These results indicate that there is a prominent hepatotoxicity in DC2P, and that there is a considerable difference in the toxicity present in DC2P and DC1P. Furthermore, in the workplace where DCPs, especially DC2P, is used, the monitoring of the working environment and biological monitoring should be mandatory.
Imazu
K
K
Third Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Fujishiro
K
K
Inoue
N
N
Koga
M
M
Iwasa
T
T
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001774:Blood Chemical Analysis; D001806:Blood Urea Nitrogen; D002728:Chlorohydrins / Q000633:toxicity*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007958:Leukocyte Count / Q000187:drug effects*; D008099:Liver / Q000187:drug effects*; D008297:Male; D010976:Platelet Count / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D000637:Transaminases / Q000097:blood; D000517:alpha-Chlorohydrin / Q000031:analogs & derivatives* / Q000633:toxicity
D002728:Chlorohydrins; C033489:1,3-dichloro-2-propanol; C076159:2,3-dichloro-1-propanol; D000517:alpha-Chlorohydrin; D007770:L-Lactate Dehydrogenase; D000637:Transaminases; D000469:Alkaline Phosphatase