Effect of (-)-epigallocatechin gallate, the main constituent of green tea, on lung metastasis with mouse B16 melanoma cell lines.
(-)-Epigallocatechin gallate (EGCG), the main polyphenolic constituent of green tea, inhibits tumor promotion and chemical carcinogenesis in animal experimental systems. Here we report that the peroral administration of EGCG inhibited metastasis of B16 melanoma cell lines, such as B16-F10 and BL6, in both experimental and spontaneous systems.
Taniguchi
S
S
Department of Molecular and Cellular Biology, Kyushu University, Fukuoka City, Japan.
Fujiki
H
H
Kobayashi
H
H
Go
H
H
Miyado
K
K
Sadano
H
H
Shimokawa
R
R
D000818:Animals; D002392:Catechin / Q000031:analogs & derivatives*; D005419:Flavonoids / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured
D005419:Flavonoids; D002392:Catechin; C057580:gallocatechol