title: Trisomy 4 in a case of acute lymphocytic leukemia (L1).
abstract: Trisomy 4 has been identified previously as a chromosome abnormality associated with acute nonlymphocytic leukemia (ANLL) with myelomonocytic lineage and in myelodysplastic syndromes (MDS). We report a case of acute lymphocytic leukemia (ALL) (French-American-British, FAB L1) in a 42-year-old Japanese man, with trisomy 4 as the sole chromosomal anomaly. Immunophenotypically, the leukemic blasts demonstrated reactivity with CD2, CD5, and CD7 and indicated on early stage of T cell.
authors.affiliation: Second Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hodohara
authors.forename: Y
authors.initials: Y
authors.lastname: Fujiyama
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: M
authors.initials: M
authors.lastname: Niwakawa
authors.forename: K
authors.initials: K
authors.lastname: Kitoh
authors.forename: A
authors.initials: A
authors.lastname: Andoh
authors.forename: T
authors.initials: T
authors.lastname: Bamba
authors.forename: S
authors.initials: S
authors.lastname: Hosoda
authors.forename: T
authors.initials: T
authors.lastname: Abe
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D002894:Chromosomes, Human, Pair 4; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000276:immunology; D014314:Trisomy
chemical_list: D015703:Antigens, CD