Intravesical electrical stimulation--an experimental analysis of the mechanism of action.
The working mechanism of intravesical electrical stimulation (IVES) was evaluated in alpha-chloralose anaesthetized cats and rats. IVES involved a direct activation of bladder mechanoreceptor afferents of the A delta type and as a consequence a central reflex activation of the detrusor. The detrusor response was abolished by bilateral transection of the S1-S3 dorsal roots and by intravesical instillation of lidocaine. The optimal stimulation frequency was 20 Hz. The results offer a theoretical rationale for the use of IVES as treatment of weak detrusor contractility in man.
Ebner
A
A
Department of Urology, University Clinic, Innsbruck, Austria.
Jiang
C
C
Lindström
S
S
D000818:Animals; D002415:Cats; D004558:Electric Stimulation / Q000379:methods; D005260:Female; D009119:Muscle Contraction / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012018:Reflex / Q000502:physiology; D001743:Urinary Bladder / Q000294:innervation / Q000502:physiology*