Neuroprotective actions of riluzole in rodent models of global and focal cerebral ischaemia.
Riluzole (2 amino 6-trifluoromethoxybenzothiazole), when administered at 4 and 8 mg/kg i.p., 0.5, 4.5, 24 and 28 h after the initiation of ischaemia, significantly reduced the prevalence of slow wave, and increased the proportion of higher frequency activity seen in the quantified electrocorticogram (ECoG), during the weeks that followed a 6 min bilateral occlusion of the common carotid arteries in the Mongolian gerbil. In focal ischaemia, provoked in Fischer rats following the occlusion of the middle cerebral artery, administration of riluzole (8 mg/kg) at 30 min and 24.5 h post occlusion significantly reduced the volume of infarcted cortex. These activities of riluzole could be related to its inhibition of sodium channel activity, which in turn inhibits glutamate release.
Pratt
J
J
Department of Biology, Rhône Poulenc Rorer, Centre de Recherche de Vitry-Alfortville, Vitry sur Seine, France.
Rataud
J
J
Bardot
F
F
Roux
M
M
Blanchard
J C
JC
Laduron
P M
PM
Stutzmann
J M
JM
D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy*; D004195:Disease Models, Animal; D004569:Electroencephalography; D005849:Gerbillinae; D002546:Ischemic Attack, Transient / Q000188:drug therapy*; D008297:Male; D051381:Rats; D019782:Riluzole; D013844:Thiazoles / Q000008:administration & dosage / Q000627:therapeutic use*
D013844:Thiazoles; D019782:Riluzole