title: Tc-99m-HMDP bone uptake quantification and plasma osteocalcin levels in hemodialysis patients--a preliminary study.
abstract: In this preliminary study plasma osteocalcin levels and Tc-99m-HMDP (Technetium 99m hydroxymetylene diphosphonate) bone uptake (BU) were measured in 10 chronic end-stage renal failure patients who were on maintenance hemodialysis. The aim of this study was to determine the correlation between bone uptake and osteocalcin-a sensitive and specific marker of osteoblastic activity. There was a statistically significant increase in both 20 and 180 minute uptake in the patient group (36 +/- 2.7 and 39 +/- 3.6) when compared to the normal volunteers (32 +/- 3.1 and 19 +/- 2.7). Plasma osteocalcin levels were also significantly high (24.5 +/- 5.6 ng/ml) when compared with normal values (6.5 +/- 2.3 ng/ml). The correlations between osteocalcin and 20 and 180 min BU were high (r = 0.62 and 0.72 respectively). In conclusion, our preliminary study suggests that, in hemodialysis patients, Tc-99m-HMDP bone uptake quantification is a sensitive and non-invasive method for showing increased osteoblastic activity.
authors.affiliation: Department of Nuclear Medicine, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
authors.forename: U
authors.initials: U
authors.lastname: Karayalcin
authors.forename: B
authors.initials: B
authors.lastname: Karayalcin
authors.forename: G
authors.initials: G
authors.lastname: Yakupoglu
authors.forename: A
authors.initials: A
authors.lastname: Yildiz
authors.forename: M
authors.initials: M
authors.lastname: Erkilic
mesh_terms: D000293:Adolescent; D000328:Adult; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000378:metabolism; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010006:Osteoblasts / Q000502:physiology; D015675:Osteocalcin / Q000097:blood*; D011877:Radionuclide Imaging; D006435:Renal Dialysis; D013669:Technetium Tc 99m Medronate / Q000493:pharmacokinetics* / Q000031:analogs & derivatives
chemical_list: D015675:Osteocalcin; C024226:technetium Tc 99m hydroxymethylene diphosphonate; D013669:Technetium Tc 99m Medronate