Physical fine mapping of genes underlying X-linked deafness and non fra (X)-X-linked mental retardation at Xq21.
Linkage studies and cytogenetically visible deletions associated with nonspecific X-linked mental retardation (XLMR) and a specific form of deafness (DFN3) have indicated that the genes responsible for these disorders are located at Xq21. Using DNA probes from this region, we have studied several overlapping deletions spanning different parts of Xq21. This has enabled us to assign the DFN3 gene and a gene for nonspecific XLMR to an interval that encompasses the locus DXS232 and that is flanked by DXS26 and DXS121.
Bach
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I
Department of Human Genetics, University Hospital Nijmegen, The Netherlands.
Robinson
D
D
Thomas
N
N
Ropers
H H
HH
Cremers
F P
FP
D000293:Adolescent; D000328:Adult; D015139:Blotting, Southern; D002648:Child; D002675:Child, Preschool; D002874:Chromosome Mapping; D003638:Deafness / Q000235:genetics*; D005600:Fragile X Syndrome; D008040:Genetic Linkage; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D014960:X Chromosome / Q000502:physiology*