Deletion mapping of H-Y antigen to the long arm of the human Y chromosome.
A gene encoding or controlling the expression of the H-Y transplantation antigen was previously mapped to the human Y chromosome. We now report the sublocalization of this gene on the long arm of the human Y chromosome. Eight patients with Y-chromosomal abnormalities were examined with a series of existing and new DNA markers for the Y chromosome. The resulting deletion map was correlated with H-Y antigen expression. We conclude that the H-Y antigen gene maps to a portion of deletion interval 6 that is identified by specific DNA markers.
Cantrell
M A
MA
Department of Pathology, University of Washington, Seattle 98195.
Bogan
J S
JS
Simpson
E
E
Bicknell
J N
JN
Goulmy
E
E
Chandler
P
P
Pagon
R A
RA
Walker
D C
DC
Thuline
H C
HC
Graham
J M
JM
D000293:Adolescent; D001483:Base Sequence; D015139:Blotting, Southern; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D004247:DNA; D005819:Genetic Markers; D006182:H-Y Antigen / Q000235:genetics*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008969:Molecular Sequence Data; D014998:Y Chromosome
D005819:Genetic Markers; D006182:H-Y Antigen; D004247:DNA