Increase in serum digoxin concentrations after indomethacin therapy in a full-term neonate.
Digoxin was administered to an 18-day-old infant who showed evidence of cardiac failure. When a Doppler echogram revealed a patent ductus, indomethacin was administered for medical management. Therapeutic digoxin doses then resulted in toxic serum concentrations of 8.2 ng/ml. Serum creatinine rose accordingly. Although this patient did not manifest signs of digoxin toxicity, practitioners should be alerted to the potential complications of these commonly used agents.
Haig
G M
GM
Department of Pharmacy, Toledo Hospital, Ohio 43606.
Brookfield
E G
EG
D003404:Creatinine / Q000097:blood; D004077:Digoxin / Q000009:adverse effects / Q000097:blood* / Q000494:pharmacology; D004347:Drug Interactions; D004374:Ductus Arteriosus, Patent / Q000097:blood / Q000150:complications / Q000188:drug therapy; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D007231:Infant, Newborn
D004077:Digoxin; D003404:Creatinine; D007213:Indomethacin