Factor VIII and coronary heart disease.
In plasma, Factor VIII is bound to its carrier protein, von Willebrand Factor (vWF). Therefore, the levels of these two factors vary together. From studies in the general population, in patients with coronary heart disease and in hemophilia patients, an association between Factor VIII levels and coronary heart disease clearly emerges.
Rosendaal
F R
FR
Department of Clinical Epidemiology, Leiden University Hospital, The Netherlands.
D001777:Blood Coagulation / Q000502:physiology*; D003328:Coronary Thrombosis / Q000097:blood / Q000209:etiology* / Q000517:prevention & control; D005169:Factor VIII / Q000502:physiology*; D006467:Hemophilia A / Q000097:blood*; D006801:Humans; D012307:Risk Factors; D014841:von Willebrand Factor / Q000502:physiology*
D014841:von Willebrand Factor; D005169:Factor VIII