Thermal behavior and elastic properties of phospholipid bilayers under the effect of a synthetic flavonoid derivative, LEW-10.
We have investigated the effect on phospholipidic bilayers of LEW-10, a synthetic flavonoid, derivative of diosmin. Two optical techniques, Quasi-elastic Light Scattering (QLS) and Fourier Transform Infrared Spectroscopy (FT-IR) were used. The results show that in the presence of LEW-10, the phase transition of the bilayers is lowered and that the elastic modulus is decreased. The FT-IR results indicate interactions in the aqueous interface regions of the bilayers. We also discuss LEW-10 comparatively with another derivative, LEW-7/S1, whose effect has been previously studied.
Azize
B
B
Laboratoire de Spectroscopie Biomoléculaire, CNRS URA no. 1430, Université Paris XIII, Bobigny, France.
Cao
A
A
Hantz-Brachet
E
E
Perret
G
G
Lewin
G
G
Taillandier
E
E
D002240:Carbohydrate Sequence; D004145:Diosmin / Q000031:analogs & derivatives*; D004548:Elasticity; D005583:Fourier Analysis; D006358:Hot Temperature; D008027:Light; D008051:Lipid Bilayers; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010743:Phospholipids; D012542:Scattering, Radiation; D013055:Spectrophotometry, Infrared
D008051:Lipid Bilayers; D010743:Phospholipids; C079519:LEW 7S1; C079520:LEW 10; D004145:Diosmin