title: Multivariate analysis of the variables affecting left ventricular filling in normal subjects.
abstract: Pulsed Doppler measurements of left ventricular filling (LVF), two-dimensional and M-mode echocardiograms were performed in 189 healthy subjects, in order to evaluate factors influencing LVF Doppler indexes in normal subjects. LVF Doppler indexes (peak E, peak A, peak E/peak A, deceleration rate of peak E (ED) were related by univariate and multivariate analyses with the following parameters: age, sex, heart rate, systolic and diastolic blood pressure, aortic root and left atrial dimensions, left ventricular mass index, left ventricular shortening fraction. The stepwise analysis showed that age by itself explained up to 18% of peak E variance, 50% of peak A variance, 61% of peak E/peak A variance and 25% of ED variance. The other variables entered into the regression, slightly improved the predictive power (less than 10%). In conclusion, age is the major independent factor affecting LVF in normal subjects, although other variables show significant correlation also after age adjustment.
authors.affiliation: Cattedra di Cardiologia, Università di Parma, Italia.
authors.forename: C
authors.initials: C
authors.lastname: Manca
authors.forename: D
authors.initials: D
authors.lastname: Aschieri
authors.forename: M
authors.initials: M
authors.lastname: Conti
authors.forename: A
authors.initials: A
authors.lastname: Piazza
authors.forename: C
authors.initials: C
authors.lastname: Moruzzi
authors.forename: A L
authors.initials: AL
authors.lastname: Barilli
authors.forename: R
authors.initials: R
authors.lastname: Bolognesi
mesh_terms: D000367:Age Factors; D001794:Blood Pressure / Q000502:physiology; D015150:Echocardiography, Doppler; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009200:Myocardial Contraction / Q000502:physiology*; D012016:Reference Values; D012737:Sex Factors; D016277:Ventricular Function, Left / Q000502:physiology*