Neuron addition in the postmetamorphic frog.
Neuron number among somatic motoneurons, sensory neurons, and sympathetic postganglionic neurons that innervate the hindlimb was correlated with body length in the bullfrog, Rana catesbeiana. Two to three times more dorsal root and sympathetic ganglion neurons are found in the largest than the smallest specimens. Hindlimb motoneurons show a 20% increase in number, but this increase is restricted to the caudal third of the motor pool. Within this region, 60% more motoneurons are found among the largest frogs. Cell division does not appear to be the mechanism of neuron addition. Instead, we propose that a pool of undifferentiated neurons mature to maintain functional capabilities as the animal increases in size.
Farel
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PB
Department of Physiology, School of Medicine, University of North Carolina, Chapel Hill 27599.
St Wecker
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PG
Wray
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SE
D000818:Animals; D002452:Cell Count; D002455:Cell Division; D006614:Hindlimb / Q000294:innervation; D008675:Metamorphosis, Biological; D009046:Motor Neurons / Q000166:cytology; D009474:Neurons / Q000166:cytology*; D009475:Neurons, Afferent / Q000166:cytology; D011892:Rana catesbeiana / Q000254:growth & development*; D013564:Sympathetic Nervous System / Q000166:cytology / Q000254:growth & development