[Acute and chronic disorders in gastric emptying after the x-ray irradiation of the rat stomach and their therapeutic modification].
After localized 300 kV X-irradiation of the rat stomach the stomach emptying time of a liquid and a solid test meal was examined with a non-invasive radiological method. In the acute period one to three weeks after irradiation with single doses between 10.7 and 21.3 Gy we observed a faster emptying of the liquid and a delayed emptying of the solid test meal. The faster emptying of the liquid test meal was treated successfully with atropine. In the chronic period we observed a delayed emptying of the liquid and of the solid test meal. These emptying disorders were treated partially successfully with the parasympathomimeticum carbachol and they were treated completely successfully with the dopamine antagonist metoclopramide.
Breiter
N
N
Institut für Strahlenbiologie der GSF, Neuherberg.
Sassy
T
T
Trott
K R
KR
D000818:Animals; D001285:Atropine / Q000008:administration & dosage; D002217:Carbachol / Q000008:administration & dosage; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects*; D008787:Metoclopramide / Q000008:administration & dosage; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D013272:Stomach Diseases / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D013997:Time Factors
D001285:Atropine; D002217:Carbachol; D008787:Metoclopramide
Akute und chronische Störungen in der Magenentleerung nach Röntgenbestrahlung des Rattenmagens und deren therapeutische Beeinflussbarkeit.