title: Changes in the amphibian antibody repertoire are correlated with metamorphosis and not with age or size.
abstract: Tadpole and adult Xenopus, manipulated to be of comparable size, exhibited stage-specific antibody expression. The production of adult-type higher-affinity anti-DNP antibodies proved to be independent of the age and size of the individual and is concomitant with the completion of metamorphosis. The appearance of new antibody specificities at such a time suggests that their expression occurs with the cell turnover and renewal during a period of morphological changes.
authors.affiliation: Department of Biology, New York University, NY 10003.
authors.forename: E
authors.initials: E
authors.lastname: Hsu
authors.forename: L
authors.initials: L
authors.lastname: Du Pasquier
mesh_terms: D000818:Animals; D000917:Antibody Formation; D001835:Body Weight; D006433:Hemocyanins / Q000276:immunology; D007814:Larva / Q000276:immunology; D008675:Metamorphosis, Biological / Q000276:immunology*; D014981:Xenopus / Q000254:growth & development* / Q000276:immunology*
chemical_list: C042158:2,4-dinitrophenyl keyhole limpet hemocyanin; D006433:Hemocyanins