title: Systemic administration of baclofen inhibits water intake in rats.
abstract: 1. The present experiments were carried out to investigate the effects of systemic administration of baclofen on water intake in rats. 2. Baclofen (1, 2 and 4 mg/kg, s.c.) inhibited water intake in 16 hr water-deprived rats in a dose-related manner, with maximal effects occurring during the first 30 min after administration. 3. Baclofen (0.25 and 2 mg/kg, s.c.) had no effects on water intake in non-deprived rats. 4. Baclofen (2 mg/kg) inhibited water intake elicited by i.p. injection of hypertonic NaCl in rats. 5. Baclofen (1 mg/kg) did not produce taste aversion in a taste aversion experiment. This indicates that the effects of baclofen on water intake is not due to an aversive effect of the drug.
authors.affiliation: Neuropharmacology Research Group, School of Pharmacy and Biomedical Science, Portsmouth Polytechnic, Hampshire, England.
authors.forename: I S
authors.initials: IS
authors.lastname: Ebenezer
authors.forename: A J
authors.initials: AJ
authors.lastname: Houston
authors.forename: T J
authors.initials: TJ
authors.lastname: Crook
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001418:Baclofen / Q000494:pharmacology*; D003864:Depression, Chemical; D004326:Drinking / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012462:Saline Solution, Hypertonic / Q000494:pharmacology; D013649:Taste / Q000187:drug effects; D014868:Water Deprivation / Q000502:physiology
chemical_list: D012462:Saline Solution, Hypertonic; D001418:Baclofen