Functional recovery after coronary revascularization for chronic coronary artery disease is dependent on maintenance of oxidative metabolism.
OBJECTIVE
This study was performed to define the importance of maintenance of oxidative metabolism as a descriptor and determinant of functional recovery after revascularization in patients with left ventricular dysfunction attributable to chronic coronary artery disease.


BACKGROUND
Although myocardial accumulation of 18F-fluorodeoxyglucose indicates the presence of tissue that is metabolically active, it may not identify those metabolic processes required for restoration of myocardial contractility. Experimental studies suggest that, under conditions of ischemia and reperfusion, maintenance of myocardial oxidative metabolism is an important metabolic determinant of the capacity for functional recovery.


METHODS
In 16 patients positron emission tomography was performed to characterize myocardial perfusion (with H(2)15O), oxidative metabolism (with 11C-acetate) and utilization of glucose (with 18F-fluorodeoxyglucose). Dysfunctional but viable myocardium was differentiated from nonviable myocardium on the basis of assessments of regional function before and after coronary revascularization. To define the importance of coronary revascularization on myocardial perfusion and metabolism, tomography was repeated in 11 patients after revascularization.


RESULTS
Before revascularization, perfusion in 24 dysfunctional but viable myocardial segments and 29 nonviable segments averaged 79% and 74%, respectively, of that in 42 normal myocardial segments (both p less than 0.01). Dysfunctional but viable myocardium exhibited oxidative metabolism comparable to that in normal myocardium. In contrast, in nonviable myocardium, oxidative metabolism was only 66% of that in normal (p less than 0.01) and 69% of that in reversibly dysfunctional myocardium (p less than 0.003). Regional utilization of glucose normalized to regional perfusion in dysfunctional but viable myocardium was greater than that in normal myocardium (p less than 0.01). However, in both reversibly and persistently dysfunctional myocardium, utilization of glucose normalized to relative perfusion was markedly variable.


CONCLUSIONS
The results indicate that preservation of oxidative metabolism is a necessary condition for recovery of function after coronary recanalization in patients with chronic coronary artery disease. Consequently, approaches that measure myocardial oxygen consumption, such as dynamic positron emission tomography with 11C-acetate, should facilitate the identification of those patients most likely to benefit from coronary revascularization.
Gropler
R J
RJ
Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, Saint Louis, Missouri 63110.
Geltman
E M
EM
Sampathkumaran
K
K
Pérez
J E
JE
Moerlein
S M
SM
Sobel
B E
BE
Bergmann
S R
SR
Siegel
B A
BA
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D003326:Coronary Circulation / Q000502:physiology; D003327:Coronary Disease / Q000378:metabolism* / Q000628:therapy; D005260:Female; D005947:Glucose / Q000378:metabolism; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization; D009206:Myocardium / Q000378:metabolism*; D010084:Oxidation-Reduction; D014055:Tomography, Emission-Computed; D016896:Treatment Outcome; D016276:Ventricular Function
D005947:Glucose