Dialysis associated mucormycosis and desferrioxamine treatment: a case report with review of the role of oxygen radicals.
A hemodialysis patient with pulmonary and cerebral mucormycosis is reported. Recently the occurrence of this infection in dialysis patients has been associated with desferrioxamine (DFO) treatment. A causal relation seems likely, but has not been proved. Several pathogenetic mechanisms are discussed, in particular the influence of DFO on host neutrophil defenses through a decreased oxygen radical production.
Seeverens
H J
HJ
Department of Medicine, Municipal Hospital Leyenburg, The Hague, Netherlands.
Tijhuis
G J
GJ
Ruijs
G J
GJ
Kazzaz
B A
BA
Kauffmann
R H
RH
D000328:Adult; D003676:Deferoxamine / Q000009:adverse effects*; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D008297:Male; D009091:Mucormycosis / Q000209:etiology*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D006435:Renal Dialysis / Q000009:adverse effects*
D005609:Free Radicals; D017382:Reactive Oxygen Species; D003676:Deferoxamine