title: [Autoimmune polyendocrinopathy and chronic mucocutaneous candidiasis].
abstract: A chronic mucocutaneous infection due to yeasts to the Candida genus can be part of the autoimmune polyglandular syndrome, described as APECS, APECED, SPA type I, CES. The authors describe the case of a young patient affected by mucocutaneous candidiasis, hypoparathyroidism and adrenal insufficiency. Chronic mucocutaneous candidiasis was diagnosed first in early childhood and was followed by the development of hypoparathyroidism (4 yrs) and adrenal insufficiency (5 yrs). The initial lesion of this syndrome is still unknown as the reason of the marked susceptibility to mucocutaneous candidiasis without systemic candidiasis. The treatment of mucocutaneous candidiasis has been improved by the introduction of orally active antifungal drugs as Ketoconazole, first, and fluconazole now.
authors.affiliation: Servizio di Endocrinologia, USL n. 7, Ospedale Regionale di Udine.
authors.forename: G
authors.initials: G
authors.lastname: Proto
authors.forename: S
authors.initials: S
authors.lastname: Leoni
authors.forename: I
authors.initials: I
authors.lastname: Torossi
authors.forename: A
authors.initials: A
authors.lastname: Mazzolini
authors.forename: F
authors.initials: F
authors.lastname: Grimaldi
authors.forename: F
authors.initials: F
authors.lastname: Bertolissi
mesh_terms: D000224:Addison Disease / Q000175:diagnosis / Q000188:drug therapy; D000293:Adolescent; D002117:Calcitriol / Q000627:therapeutic use; D002178:Candidiasis, Chronic Mucocutaneous / Q000175:diagnosis* / Q000188:drug therapy; D003348:Cortisone / Q000031:analogs & derivatives / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D005438:Fludrocortisone / Q000627:therapeutic use; D006801:Humans; D007011:Hypoparathyroidism / Q000175:diagnosis / Q000188:drug therapy; D016884:Polyendocrinopathies, Autoimmune / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D015725:Fluconazole; D002117:Calcitriol; D005438:Fludrocortisone; D003348:Cortisone
vernacular_title: Poliendocrinopatia autoimmune e candidiasi mucocutanea cronica.