title: [PHARMFIT--a program for the evaluation of digitally collected cardiovascular parameters].
abstract: The PHARMFIT program allows the non-linear fit of simple and combined cosine functions to data from long-term monitoring of cardiovascular parameters and the statistical evaluation of the quality of fit. With the SYNOPS utility a statistical comparison of different fit models can be achieved. As an example, the systolic blood-pressure data obtained in a hypertensive subject by ambulatory blood-pressure monitoring (ABPM) over a period of 36 h is used. The program demonstrates that the fit of a combined cosine function including a 24-h and a 12-h period describes the data better than a simple 24-h cosine function. The quality of fit is significantly improved by inclusion of the first harmonics. The PHARMFIT program can help to get a better analysis of ABPM data.
authors.affiliation: Zentrum der Pharmakologie, J.W. Goethe-Universität, Frankfurt/Main.
authors.forename: A
authors.initials: A
authors.lastname: Mattes
authors.forename: K
authors.initials: K
authors.lastname: Witte
authors.forename: B
authors.initials: B
authors.lastname: Lemmer
mesh_terms: D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D015924:Blood Pressure Monitors / Q000706:statistics & numerical data*; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology*; D003692:Delayed-Action Preparations; D004110:Diltiazem / Q000008:administration & dosage; D004334:Drug Administration Schedule; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*; D012984:Software
chemical_list: D003692:Delayed-Action Preparations; D004110:Diltiazem
vernacular_title: PHARMFIT--ein Programm zur Auswertung digital erfasster kardiovaskulärer Messdaten.