Increased serum levels of soluble interleukin 2 receptor in patients with drug-induced allergic hepatitis.
Soluble interleukin 2 receptor (sIL2R) level in the serum of 10 patients with drug-induced allergic hepatitis (DIAH) were quantified with a solid-phase enzyme immunoassay using two monoclonal antibodies against the receptor. The sIL2R levels in patients with DIAH were significantly higher than in 15 normal subjects (p less than 0.01). The high sIL2R levels observed during the florid stage of DIAH returned to normal during convalescence (p less than 0.05). SIL2R from the serum of DIAH patients was found to bind to a recombinant IL2 affinity column. It seems likely that sIL2R inhibits the hyper-immune reaction that occurs in drug allergies due to bind IL2. But, we have no data that sIL2R inhibits actually the biological activity of IL2.
Onji
M
M
Third Department of Internal Medicine, Ehime University School of Medicine.
Masumoto
T
T
Ohta
Y
Y
D056486:Chemical and Drug Induced Liver Injury / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007376:Interleukin-2 / Q000378:metabolism*; D015375:Receptors, Interleukin-2 / Q000032:analysis* / Q000378:metabolism; D012995:Solubility
D007376:Interleukin-2; D015375:Receptors, Interleukin-2