Influence of food on serum ambenonium concentration in patients with myasthenia gravis.
Influence of food on the serum concentration and kinetics ambenonium chloride (AMBC) has been examined in thirteen patients with myasthenia gravis (MG). Mean serum concentrations and Cmax during fasting were higher than those in the non-fasting state. The AUC (0-3 h) was also about four-times larger. The drug effects versus the serum concentration were observed to be anti-clockwise or clockwise. The effective range of the Cmax varied between patients. The unexpected increase in Cmax led to adverse muscarinic actions of AMBC, when the condition was changed from the nonfasting to the fasting state. It is recommended that the dose be changed during non-fasting treatment when adjusting the optimum regimen for patients myasthenia gravis. Patients must be advised to keep to the dosing and dietary schedule in order to avoid unexpected adverse actions to AMBC.
Ohtsubo
K
K
Department of Hospital Pharmacy, Tottori University Hospital, Japan.
Fujii
N
N
Higuchi
S
S
Aoyama
T
T
Goto
I
I
Tatsuhara
T
T
D000328:Adult; D000368:Aged; D000549:Ambenonium Chloride / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D005215:Fasting / Q000097:blood; D005260:Female; D005502:Food; D006801:Humans; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000097:blood*
D000549:Ambenonium Chloride