title: Dosing problems in the use of topical ophthalmic drops.
abstract: The effect of two drops of the same drug, one instilled immediately after the other, was compared to the effect of a single drop in 100 healthy volunteers. The drugs investigated were tropicamide, 0.125%, and phenylephrine, 2.5%. The mydriatic effect of two drops was 30%-35% stronger than the effect achieved by a single drop.
authors.affiliation: Department of Ophthalmology, Ichilov Hospital, Tel Aviv, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Loewenstein
authors.forename: O
authors.initials: O
authors.lastname: Geyer
authors.forename: A
authors.initials: A
authors.lastname: Blanc
authors.forename: M
authors.initials: M
authors.lastname: Lazar
mesh_terms: D000328:Adult; D006801:Humans; D009883:Ophthalmic Solutions; D010656:Phenylephrine / Q000008:administration & dosage* / Q000494:pharmacology; D011680:Pupil / Q000187:drug effects*; D014331:Tropicamide / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D009883:Ophthalmic Solutions; D010656:Phenylephrine; D014331:Tropicamide