Properties of favored patterns in spontaneous spike trains and responses of favored patterns to electroacupuncture in evoked trains.
By using 'the modified detection method', our previous study has shown that all spontaneous spike trains recorded from several areas of brain and spinal cord have favored patterns (FPs). The present study further shows that: (1) all newly detected spike trains from substantia nigra zona compacta, nucleus periventricularis hypothalami and nucleus hypothalamicus posterior also have FPs, and some spike trains from neurons in the same nucleus have a common favored pattern (CF, i.e. they share the same FP), indicating that FP and CF in spike trains are common phenomena; (2) all serial correlation coefficients of FP repetitions (in serial order) in different spike trains detected are less than 0.3 (close to 0), revealing that the repetition of FPs is a renewal process; (3) in different periods of the spike trains evoked by electroacupuncture (EA), the number of different FPs and the number of repetitions of the same representative FP either increase or decrease along with the change of firing rate. The tendencies of these changes are very similar, but after EA the repetitions of different FPs in the same spike trains change differently, showing that different (hidden) responses exist at the same time. The above results suggest that the FPs in spike trains may represent various neural codes, and 'the modified detection method of FP' can pick up more information from spike trains than the firing rate analysis, hence it is a very useful tool for the study of neural coding.
Chen
Y Q
YQ
Department of Physiology, Beijing Medical University, People's Republic of China.
Ku
Y H
YH
D000818:Animals; D001921:Brain / Q000502:physiology*; D015671:Electroacupuncture; D005071:Evoked Potentials; D006801:Humans; D007034:Hypothalamus, Posterior / Q000502:physiology; D008838:Microcomputers; D008959:Models, Neurological; D009010:Monte Carlo Method; D009474:Neurons / Q000502:physiology*; D010286:Paraventricular Hypothalamic Nucleus / Q000502:physiology; D013116:Spinal Cord / Q000502:physiology*; D013378:Substantia Nigra / Q000502:physiology