[Acquired rifampicin resistance during M. kansasii infection in a patient with AIDS].
A man with AIDS and M. kansasii lung infection received rifampicin and isoniazid for 9 months, combined with ethambutol for four months. The treatment was effective with sputum culture negativation, but relapse occurred. The minimal inhibitory concentration of rifampicin for the M. kansasii strain was respectively 0.2 microgram/ml at the onset and 128 micrograms/ml after the treatment, giving evidence of acquired resistance. A new treatment was initiated but is was ineffective.
Dautzenberg
B
B
Service de Pneumologie, Groupe Hospitalier Pitié-Salpêtrière, Paris.
Antoun
F
F
Truffot
C
C
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D004352:Drug Resistance, Microbial; D006801:Humans; D008297:Male; D009165:Mycobacterium Infections, Nontuberculous / Q000000981:diagnostic imaging / Q000188:drug therapy*; D009170:Nontuberculous Mycobacteria / Q000187:drug effects*; D012008:Recurrence; D012293:Rifampin / Q000494:pharmacology*; D014057:Tomography, X-Ray Computed; D014397:Tuberculosis, Pulmonary / Q000000981:diagnostic imaging / Q000188:drug therapy*
D012293:Rifampin
Résistance acquise à la rifampicine au cours d'une infection à M. kansasii chez un patient atteint de SIDA.