title: Interaction of androgens and prolactin on prostatic enzymes of the pyruvate-malate cycle involved in lipogenesis in castrated mature monkey, Macaca radiata.
abstract: Effects of androgens, prolactin (Prl) and bromocriptine (Br) on the specific activities of prostatic (caudal and cranial) enzymes of the pyruvate-malate cycle were studied in castrated mature bonnet monkeys. Castration decreased the activity of NADP+ isocitrate dehydrogenase (ICDH), ATP citrate lyase, malate dehydrogenase (MDH), malic enzyme and fatty acid synthase (FAS). Administration of testosterone propionate (TP)/dihydrotestosterone (DHT) increased the activities of all these enzymes in both lobes. Malate dehydrogenase maintained normal activity. Prl also had a stimulatory effect on the enzymes and was further enhanced when Prl was given in combination with TP/DHT. Unlike Prl, bromocriptine treatment inhibited all the enzymes in both lobes. Thus, prolactin was found to have a direct as well as a synergistic effect with androgens on enzymes of the pyruvate-malate cycle in the prostate of castrated mature monkeys.
authors.affiliation: Department of Endocrinology, University of Madras, India.
authors.forename: J
authors.initials: J
authors.lastname: Arunakaran
authors.forename: K
authors.initials: K
authors.lastname: Balasubramanian
authors.forename: N
authors.initials: N
authors.lastname: Srinivasan
authors.forename: M M
authors.initials: MM
authors.lastname: Aruldhas
authors.forename: P
authors.initials: P
authors.lastname: Govindarajulu
mesh_terms: D001275:ATP Citrate (pro-S)-Lyase / Q000378:metabolism; D000728:Androgens / Q000502:physiology*; D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology; D064429:Fatty Acid Synthases / Q000378:metabolism; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D008055:Lipids / Q000096:biosynthesis; D008255:Macaca radiata; D008291:Malate Dehydrogenase / Q000378:metabolism; D008293:Malates / Q000378:metabolism*; D008297:Male; D009919:Orchiectomy; D011388:Prolactin / Q000502:physiology*; D011467:Prostate / Q000201:enzymology*; D011773:Pyruvates / Q000378:metabolism*
chemical_list: D000728:Androgens; D008055:Lipids; D008293:Malates; D011773:Pyruvates; D001971:Bromocriptine; D011388:Prolactin; D008291:Malate Dehydrogenase; D007521:Isocitrate Dehydrogenase; C039355:isocitrate dehydrogenase (NADP+); D064429:Fatty Acid Synthases; D001275:ATP Citrate (pro-S)-Lyase