Simulation of compartmental models for kinetic data from a positron emission tomograph.
Linear compartmental models are used to describe the disposition of radio-labelled compounds in regions of interest in the mammalian body, based on a time sequence of measurements from a positron emission tomograph (PET). In this paper we show how closed form solutions for the model equations have been incorporated into a computer program for simulation and parameter estimation. A typical PET data example is included to illustrate the implementation and compare the closed form method with a numerical ode solution method.
Coxson
P G
PG
Center for Functional Imaging, Lawrence Berkeley Lab, CA 94720.
Salmeron
E M
EM
Huesman
R H
RH
Mazoyer
B M
BM
D001825:Body Fluid Compartments / Q000502:physiology*; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D003198:Computer Simulation; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008954:Models, Biological; D014055:Tomography, Emission-Computed
D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose