[Inhibition of reproduction of the human immunodeficiency virus in cell culture by 2',3'-dideoxynucleoside-5'-phosphites].
5'-Phosphites (5'-hydrogenphosphonates) of 2',3'-dideoxynucleosides (T, A, G, C) were synthesized and studied as inhibitors of human immunodeficiency virus type 1 (HIV-1) in MT4 and CEM13 cell cultures. It was shown that all 5'-phosphites effectively inhibit the production of viral antigens and protect cells from the cytotoxic effect of HIV infection. 5'-Phosphites were more active antiviral compounds than the corresponding nucleosides.
Karamov
E V
EV
Lukashov
V V
VV
Gorbacheva
A P
AP
Makarova
T V
TV
Kornilaeva
G V
GV
Tarusova
N B
NB
Kraevskiĭ
A A
AA
D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D015224:Dideoxynucleosides / Q000494:pharmacology*; D054306:Dideoxynucleotides; D004797:Enzyme-Linked Immunosorbent Assay; D015488:HIV Antigens / Q000032:analysis; D015497:HIV-1 / Q000502:physiology*; D013942:Thymine Nucleotides / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology
D000998:Antiviral Agents; D015224:Dideoxynucleosides; D054306:Dideoxynucleotides; D015488:HIV Antigens; D013942:Thymine Nucleotides; D015215:Zidovudine; C052873:zidovudine triphosphate
Ingibirovanie reproduktsii virusa immunodefitsita cheloveka v kul'ture kletok 5'-fosfitami 2'-3'-didezoksinukleosidov]