Effect of castration and testosterone therapy on harderian gland protein patterns of the golden hamster (Mesocricetus auratus).
1. Sodium dodecyl sulphate 7-12% gradient polyacrylamide gel electrophoresis of male and female hamster Harderian gland whole homogenate shows a clear-cut sexual dimorphism, which consists of the presence of two male-specific glycoproteins (168 and 116 kDa) and two specific female proteins (210 and 190 kDa). 2. In the male, castration causes a significant decrease in the concentration of the two glycoprotein fractions. 3. Replacement therapy with testosterone propionate (T) restores the intact male pattern.
Varriale
B
B
Dipartimento di Fisiologia Umana e Funzioni Biologische Integrate F. Bottazzi, University of Naples, Italy.
Serino
I
I
Minucci
S
S
Chieffi
G
G
D000818:Animals; D006224:Cricetinae; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006023:Glycoproteins / Q000302:isolation & purification / Q000378:metabolism*; D006243:Harderian Gland / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008647:Mesocricetus; D009919:Orchiectomy; D012727:Sex Characteristics; D013737:Testis / Q000502:physiology; D013739:Testosterone / Q000494:pharmacology
D006023:Glycoproteins; D013739:Testosterone