Genotoxicity studies of the food additive ester gum.
Ester gum (EG) is used in citrus oil-based beverage flavourings as a weighting or colouring agent. In the present study, concentrations of 50, 100 and 150 mg/kg body weight were administered orally to male Swiss albino mice, and sister chromatid exchange and chromosomal aberration were used as the cytogenetic endpoints to determine the genotoxic and clastogenic potential of the food additive. Although EG was weakly clastogenic and could induce a marginal increase in sister chromatid exchange frequencies, it was not a potential health hazard at the doses tested.
Mukherjee
A
A
Centre for Advanced Study in Cell and Chromosome Research, University of Calcutta, India.
Agarwal
K
K
Chakrabarti
J
J
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations; D004224:Diterpenes / Q000633:toxicity*; D005503:Food Additives / Q000633:toxicity*; D008297:Male; D051379:Mice; D012854:Sister Chromatid Exchange / Q000187:drug effects
D004224:Diterpenes; D005503:Food Additives; C041216:Foral 85