[Laser flow cytometry in the diagnosis of chronic hepatitis of different etiologies].
A study was made of the immune status in patients suffering from chronic hepatitis (CH) of viral, alcoholic and toxic etiology. The T-system cellular immunity (OKT-3+, OKT-4+, OKT-8+, OKT-11+) was subjected to a subpopulation analysis using monoclonal antibodies and flow laser cytometry. CH of varying etiology is marked by impairment of the immune status. Especially manifest are suppression of OKT-3(+)-, OKT-4(+)-, OKT-8(+)-positive cells and imbalance of OKT-4+ and OKT-8+, with the changes revealed being dependent on the etiological pattern of CH. The data obtained point to the development of secondary immunodeficiency of the T-cell component at the level of different T lymphocyte subpopulations, which depends on the clinico-morphological and etiological pattern of CH. The revealed changes in the immune system may serve as a criterion for differential diagnosis and elaboration of efficient immunocorrective therapy of CH.
Kasymov
I Iu
IIu
Zakirkhodzhaev
Sh Ia
ShIa
Tashpulatov
Kh A
KhA
Nurmukhamedova
R A
RA
D000328:Adult; D000917:Antibody Formation / Q000276:immunology; D002908:Chronic Disease; D003937:Diagnosis, Differential; D005260:Female; D005434:Flow Cytometry; D006505:Hepatitis / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D007834:Lasers; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology
Lazerno-protochnaia tsitometriia v diagnostike khronicheskikh gepatitov razlichnoĭ étiologii.