[Transferability of meropenem to cerebrospinal fluid in rabbits with meningitis caused by Staphylococcus aureus].
The transferability of meropenem (MEPM) to cerebrospinal fluid (CSF) was studied employing rabbits with experimental meningitis caused by Staphylococcus aureus. The mean serum concentration was 93.1 +/- 13.5 micrograms/ml at 15 minutes after intravenous administration of MEPM at a dose level of 100 mg/kg. The mean concentration in CSF was maximum at 15 minutes after administration at 4.42 +/- 2.24 micrograms/ml. Pharmacokinetic parameters calculated from these values were as follows: Cmax (CSF/serum) 4.75%, AUC (CSF/serum) 10.4% between 15 and 60 minutes, 13.9% between 15 and 120 minutes and 15.7% between 15 and 180 minutes, T 1/2 for MEPM in CSF: 50.9 minutes, T 1/2 (CSF/serum): 2.19. In comparison to those of imipenem which were obtained in the same way, the transferability of MEPM was similar and in consideration of the antimicrobial potency against the main pathogens of meningitis, it appears worth-while of running clinical trials for this drug.
Haruta
T
T
Department of Pediatrics, Kobe City General Hospital.
Okura
K
K
Kuroki
S
S
Nikami
H
H
Kobayashi
Y
Y
D000818:Animals; D001692:Biological Transport; D006207:Half-Life; D008581:Meningitis / Q000134:cerebrospinal fluid* / Q000188:drug therapy / Q000382:microbiology; D000077731:Meropenem; D011817:Rabbits; D013203:Staphylococcal Infections; D013211:Staphylococcus aureus; D013845:Thienamycins / Q000134:cerebrospinal fluid* / Q000493:pharmacokinetics / Q000627:therapeutic use
D013845:Thienamycins; D000077731:Meropenem