title: [Effect of insulin-like growth factor I (IGF-I) on Sertoli cell metabolism in the pubescent rat].
abstract: The influence of Insulin-like Growth Factor I (IGF-I) on some metabolic functions of Sertoli cells from peripubertal rats was investigated. Sertoli cells were isolated from the testes of 24-day-old animals and cultured at 32 degrees C in Eagle's MEM with or without 1 nM IGF-I. Sertoli cells cultured in the presence of IGF-I showed increased nuclear RNA polymerase activity (+80%) and augmented protein synthesis (+50%).
authors.affiliation: Istituto di Fisiologia Generale, Università di Genova.
authors.forename: M
authors.initials: M
authors.lastname: Prati
authors.forename: S
authors.initials: S
authors.lastname: Palmero
authors.forename: P
authors.initials: P
authors.lastname: De Marco
authors.forename: P
authors.initials: P
authors.lastname: Trucchi
authors.forename: E
authors.initials: E
authors.lastname: Fugassa
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D008297:Male; D014176:Protein Biosynthesis; D012319:RNA Polymerase II / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012708:Sertoli Cells / Q000187:drug effects* / Q000378:metabolism; D012741:Sexual Maturation; D013268:Stimulation, Chemical
chemical_list: D007334:Insulin-Like Growth Factor I; D012319:RNA Polymerase II
vernacular_title: Effetti del fattore di crescita insulino-simile I (IGF-I) sul metabolismo della cellula di Sertoli nel ratto pubere.