title: Hypotensive anesthesia for middle ear surgery: a comparison of propofol infusion and isoflurane.
abstract: An infusion of propofol (2,6-diisopropylphenol) was compared with isoflurane to induce hypotension for middle ear surgery. Forty patients (ASA physical status I-II, 16-55 years) scheduled for elective surgery were included in an open randomized study. The pharmacokinetics of propofol infusion were also studied in 6 patients. Both agents produced controlled hypotension (MAP reduction of 30% from the baseline values) with an acceptable visibility of the surgical field. No major complications occurred. The mean total dose of propofol infusion was 6.4 +/- 2.7 mg/kg and the mean concentration of isoflurane was 0.9 +/- 0.4%. Considerable interindividual pharmacokinetic variability was found and propofol was extensively distributed and rapidly cleared from the body after the infusion. Propofol infusion may be a new alternative as a hypotensive agent in middle ear surgery.
authors.affiliation: Department of Anaesthesiology, University of Turku, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Valtonen
authors.forename: K
authors.initials: K
authors.lastname: Kuttila
authors.forename: J
authors.initials: J
authors.lastname: Kanto
authors.forename: A
authors.initials: A
authors.lastname: Pakkanen
authors.forename: P
authors.initials: P
authors.lastname: Rosenberg
mesh_terms: D000293:Adolescent; D000328:Adult; D000758:Anesthesia; D001794:Blood Pressure / Q000187:drug effects; D004432:Ear, Middle / Q000601:surgery*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007023:Hypotension, Controlled; D007262:Infusions, Intravenous; D007530:Isoflurane; D008297:Male; D008875:Middle Aged; D011229:Preanesthetic Medication; D015742:Propofol / Q000008:administration & dosage / Q000493:pharmacokinetics
chemical_list: D007530:Isoflurane; D015742:Propofol