title: Reactivity of hypervalent iron with biological compounds.
abstract: Although it is well established that the ferryl (Fe==O2+) and perferryl (Fe==O3+) oxidation states of iron have a beneficial role in enzymatic oxidation and hydroxylation processes, as small complexes that are suspected to be formed in Fenton reactions, they may have deleterious effects on living cells. I discuss the basic chemistry of small hypervalent iron complexes. Their reactivity with biological compounds is illustrated by considering ascorbic acid and essential amino acids. A method is proposed for the determination of the ratio of [.OH]/[ferryl] in Fenton-type reactions.
authors.affiliation: Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973.
authors.forename: B H
authors.initials: BH
authors.lastname: Bielski
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D001205:Ascorbic Acid / Q000737:chemistry; D005609:Free Radicals; D006801:Humans; D007501:Iron / Q000737:chemistry*; D008956:Models, Chemical; D010084:Oxidation-Reduction
chemical_list: D000596:Amino Acids; D005609:Free Radicals; D007501:Iron; D001205:Ascorbic Acid