Comparison of adult height between patients with XX and XY gonadal dysgenesis: support for a Y specific growth gene(s).
Adult height was compared between published cases of patients with XX gonadal dysgenesis (XXGD) and those with XY gonadal dysgenesis (XYGD). The mean adult height of XYGD patients (171.0 cm (SD 7.8), n = 27) was significantly greater than that of XXGD patients (164.4 cm (7.7), n = 27) (p less than 0.01). This finding supports the existence of a Y specific growth gene(s) which promotes statural growth independently of the effects of gonadal sex steroids.
Ogata
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T
Human Molecular Genetics Laboratory, Imperial Cancer Research Fund, London.
Matsuo
N
N
D000328:Adult; D001827:Body Height / Q000235:genetics*; D005260:Female; D006059:Gonadal Dysgenesis / Q000235:genetics*; D006061:Gonadal Dysgenesis, 46,XY / Q000235:genetics*; D012739:Gonadal Steroid Hormones / Q000502:physiology; D006801:Humans; D008297:Male; D014998:Y Chromosome
D012739:Gonadal Steroid Hormones