Biocompatibility of synthetic oxygen carriers and fluorosurfactants.
A system for testing the biocompatibility of synthetic oxygen carriers is described including tests of hemolysis, complement activation and proliferation of cell lines or lymphocytes. Of 17 surfactants tested in this system, 6 were compatible in all tests while the other compounds showed individually differing patterns of incompatibility. We conclude that, in order to conduct a meaningful screening, a series of different assays has to be applied. In addition to our system, further assays, covering cytokine induction and phagocytosis should be attempted.
Northoff
H
H
DRK-Blutspendezentrale Ulm, FRG.
Haidmann
L
L
Hänsch
G
G
Reuter
P
P
Mader
J
J
Meinert
H
H
D001802:Blood Substitutes / Q000633:toxicity*; D002460:Cell Line; D003167:Complement Activation / Q000187:drug effects*; D005466:Fluorocarbons / Q000633:toxicity*; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D008422:Materials Testing; D011060:Poloxalene / Q000633:toxicity; D013329:Structure-Activity Relationship; D013501:Surface-Active Agents / Q000633:toxicity*
D001802:Blood Substitutes; D005466:Fluorocarbons; D013501:Surface-Active Agents; D011060:Poloxalene