Neuronal network analysis of serum electrophoresis.
OBJECTIVE
To advise a system of neuronal networks which can classify the densitometric patterns of serum electrophoresis.


METHODS
Digitised data containing 83 normal and 132 pathological serum protein electrophoresis patterns were presented to four neuronal networks containing 1900 neurons. Network 1 evaluates the integrated values of the albumin, alpha 1, alpha 2, beta and gamma fractions together with total protein (Biuret method). Networks 2, 3, and 4 analyse the shape of the albumin, beta and gamma fractions. To increase the sensitivity for the detection of monoclonal gammopathies a Fourier transformation was applied to the beta and gamma fractions.


RESULTS
After a learning period of 20 minutes (back-propagation learning algorithm) the system was tested with a set of electrophoresis patterns comprising 446 routinely collected samples. It differentiated between physiological and pathological curves with a sensitivity of 97.5% and a specificity of 98.8%, with 86% correct diagnoses. All monoclonal gammopathies were recognised by the Fourier detector.


CONCLUSIONS
Neuronal networks could be useful for certain medical uses. Unlike rule based systems, neuronal networks do not have to be programmed but have the capacity to "learn" quickly.
Kratzer
M A
MA
Institut für Klinische Chemie, Ludwig-Maximilians-Universität München, Germany.
Ivandic
B
B
Fateh-Moghadam
A
A
D001797:Blood Protein Electrophoresis; D003720:Densitometry / Q000145:classification; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D005583:Fourier Analysis; D006801:Humans; D016571:Neural Networks, Computer