title: Correlation between the induction of an immediate early gene, zif/268, and long-term potentiation in the dentate gyrus.
abstract: Expression of the immediate early gene zif/268 (also termed NGFI-A, Krox 24, TIS8 and Egr-1) was investigated in awake rats following various long-term potentiation (LTP) induction protocols. zif/268 mRNA (Northern blots) and protein (immunohistochemistry) levels sharply increased following LTP, and followed a time course characteristic of other immediate early genes. When measured across 3 tetanization protocols known to produce differing degrees of LTP persistence, zif/268 induction was found to be more highly correlated with LTP duration than with the magnitude of initial LTP. These data support the hypothesis that the immediate early gene zif/268 plays a role as a third messenger in the cascade of cellular and nuclear events that govern the persistence of LTP.
authors.affiliation: Department of Biochemistry, University of Otago, Dunedin, New Zealand.
authors.forename: C L
authors.initials: CL
authors.lastname: Richardson
authors.forename: W P
authors.initials: WP
authors.lastname: Tate
authors.forename: S E
authors.initials: SE
authors.lastname: Mason
authors.forename: P A
authors.initials: PA
authors.lastname: Lawlor
authors.forename: M
authors.initials: M
authors.lastname: Dragunow
authors.forename: W C
authors.initials: WC
authors.lastname: Abraham
mesh_terms: D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D005071:Evoked Potentials / Q000502:physiology; D015870:Gene Expression / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D007150:Immunohistochemistry; D008297:Male; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics*; D015345:Oligonucleotide Probes; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D009419:Nerve Tissue Proteins; D015345:Oligonucleotide Probes; D012333:RNA, Messenger