[Hepatotoxicity of cyclochlorotine--a cyclic peptide produced by Penicillium islandicum].
Toxicological investigations of "Yellow Rice" which have been contaminated with various Penicillium species have shown that Penicillium islandicum apart from well-known hepatotoxic mycotoxin, lyteoskyrin synthesizes cyclochlorotine (chloropeptide, CP), which is also hepatotoxic. Isolation of chloropeptide and its chemical characteristics, acute toxicity and biochemical alterations, tissue distribution and excretion, deformation of hepatic cells, and interaction with cytoskeleton filaments are described. It is shown that the hepatotoxicity of CP is inactivated by dehalogenation of CP by the cytochrome P-450 system.
Ueno
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Y
Department of Toxicology and Microbial Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan.
D000818:Animals; D002850:Chromatography, Gel; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003599:Cytoskeleton / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D009183:Mycotoxins / Q000096:biosynthesis / Q000633:toxicity*; D010407:Penicillium / Q000378:metabolism*; D010456:Peptides, Cyclic / Q000096:biosynthesis / Q000633:toxicity*; D014018:Tissue Distribution
D009183:Mycotoxins; D010456:Peptides, Cyclic; C018925:chloropeptide; D003577:Cytochrome P-450 Enzyme System
Gepatotoksichnost' tsiklokhlorotina--tsiklicheskogo peptida, produtsiruemogo Penicillium islandicum Sopp.