Growth-related proteinases in cultured human tumour cells.
The proliferation of normal cells, and of early-passage cells from tumours, is inhibited as a consequence of inhibition of a cell-surface proteinase activity. In contrast, established tumour cell lines are usually resistant to these effects. It has previously been suggested that the change from sensitivity to resistance may be a consequence of tumour progression, but experiments with an additional three human tumour cell cultures show that this change is not inevitable.
Scott
G K
GK
Department of Biochemistry, University of Auckland.
Tse
C A
CA
D000595:Amino Acid Sequence; D002277:Carcinoma / Q000201:enzymology; D002455:Cell Division; D003110:Colonic Neoplasms / Q000201:enzymology; D010450:Endopeptidases / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D014407:Tumor Cells, Cultured; D000515:alpha 1-Antitrypsin / Q000494:pharmacology
D000515:alpha 1-Antitrypsin; D010450:Endopeptidases