title: Measurement of urinary orotic acid by gas chromatography-mass spectrometry.
abstract: Urinary excretion of orotic acid is increased in many inborn errors of ureagenesis and some other diseases. Urine orotic acid is found to be accurately measured by gas chromatography-mass spectrometry (GC-MASS) under the conditions for organic acids analysis. Therefore, GC-MASS analysis of urine is also helpful in the diagnosis of urea cycle disorders in patients with hyperammonemia. Specific tests for orotic acid measurement are not necessary if urine organic acids analysis is available.
authors.affiliation: Department of Pediatrics, National Taiwan University Hospital, Taipei, R.O.C.
authors.forename: W L
authors.initials: WL
authors.lastname: Hwu
authors.forename: S P
authors.initials: SP
authors.lastname: Chou
authors.forename: T R
authors.initials: TR
authors.lastname: Wang
mesh_terms: D002138:Calibration; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007223:Infant; D009963:Orotic Acid / Q000652:urine*
chemical_list: D009963:Orotic Acid