Effect of chronic administration of dexfenfluramine on blood pressure in salt-sensitive rats.
Chronic administration of dexfenfluramine, at a relatively low daily dose, slowed the development of salt-induced elevation of blood pressure in salt-sensitive (Dahl DS and Rapp SS) rats. This effect could not be accounted for by drug-related anorexia alone. Elevated serotonin activity, possibly in the brain, may underlie this antihypertensive action of dexfenfluramine.
Rowland
N E
NE
Department of Psychology, University of Florida, Gainesville 32611.
Fregly
M J
MJ
Poortman
C M
CM
Li
H
H
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005277:Fenfluramine / Q000627:therapeutic use*; D006973:Hypertension / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012680:Sensitivity and Specificity; D012965:Sodium Chloride / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D005277:Fenfluramine; D012965:Sodium Chloride