title: Comparison of the effects of volatile anesthetics in varying concentrations on brain energy metabolism with brain ischemia in rats.
abstract: The effects of varying concentrations and types of volatile anesthetics on neurochemical sequelae of brain ischemia were evaluated in the rat. Rats were assigned to treatment defined by a 3 x 3 design (anesthetic type and dose) with 5 rats/cell. Each group received halothane, enflurane, or isoflurane 0.5, 1.0, or 2.0 MAC (minimal alveolar concentration). This was followed by preischemic plasma glucose sampling, 5 min hypotension (30 mmHg) and 5 min decapitation cerebral ischemia. Preischemia plasma glucose increased with increasing anesthetic concentration and was highest in the isoflurane groups, varying from a low (+/- SD) of 7.19 +/- 1.79 mumol/ml in the 0.5 MAC halothane group to a high of 12.68 +/- 3.65 mumol/ml in the 2.0 MAC isoflurane group. End-ischemic brain lactate correlated with preischemic plasma glucose (r = 0.5, alpha = 0.5). We conclude that increasing concentration of volatile anesthesia with iv phenylephrine blood pressure support produces higher levels of plasma glucose and brain lactate with cerebral ischemia.
authors.affiliation: Department of Anesthesia, College of Medicine, University of Florida, Gainesville.
authors.forename: M
authors.initials: M
authors.lastname: Zapp
authors.forename: W A
authors.initials: WA
authors.lastname: Kofke
authors.forename: D W
authors.initials: DW
authors.lastname: Davis
mesh_terms: D000777:Anesthetics; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002545:Brain Ischemia / Q000378:metabolism*; D004734:Energy Metabolism / Q000187:drug effects*; D008297:Male; D051381:Rats; D014835:Volatilization
chemical_list: D000777:Anesthetics