Heterotopic bone formation induced by bone morphogenetic protein in mice with collagen-induced arthritis.
A study was conducted to investigate the influence of systemic inflammation on heterotopic bone formation induced by bone morphogenetic protein (BMP). Five-milligram pellets of BMP were implanted in mice with type II collagen-induced arthritis. Intraperitoneal injections of interleukin-1 (IL-1) were also administered to a group of mice without collagen-induced arthritis. The amount of BMP-induced heterotopic bone formation was evaluated by soft X-ray radiography, histology, and assay of calcium content. BMP-induced heterotopic bone formation was markedly enhanced in mice with collagen-induced arthritis, and also in IL-1-treated mice. These findings suggest that bone formation is enhanced in mice with collagen-induced arthritis, and that IL-1 may be responsible.
Fujimori
Y
Y
Department of Orthopaedic Surgery, Faculty of Medicine, Kyoto University, Japan.
Nakamura
T
T
Ijiri
S
S
Shimizu
K
K
Yamamuro
T
T
D000818:Animals; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000503:physiopathology*; D001846:Bone Development / Q000187:drug effects* / Q000502:physiology; D019485:Bone Morphogenetic Proteins; D001842:Bone and Bones / Q000502:physiology; D002118:Calcium / Q000378:metabolism; D002417:Cattle; D003094:Collagen; D004343:Drug Implants; D006133:Growth Substances / Q000494:pharmacology*; D007249:Inflammation; D007375:Interleukin-1 / Q000494:pharmacology; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D011506:Proteins / Q000302:isolation & purification / Q000494:pharmacology*
D019485:Bone Morphogenetic Proteins; D004343:Drug Implants; D006133:Growth Substances; D007375:Interleukin-1; D011506:Proteins; D003094:Collagen; D002118:Calcium