Tiletamine hydrochloride in combination with zolazepam hydrochloride as an anaesthetic agent in sheep.
The anaesthetic effects of Zoletil, a 1:1 combination of tiletamine and zolazepam, was evaluated in 10 sheep. The optimum dose of this preparation was found to be 12 mg kg-1. It produced rapid induction, cataleptoid anaesthesia and smooth recovery with a minimal effect on blood pressure. Individual sheep, however, displayed variable reactions to the anaesthetic. Atropine premedication at 0.04 mg kg-1 did not have any significant effect on either heart rate or blood pressure when compared to Zoletil alone.
Taylor
J H
JH
Department of Physiology, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, Republic of South Africa.
Botha
C J
CJ
Swan
G E
GE
Mülders
M S
MS
Grobler
M J
MJ
D000777:Anesthetics / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004338:Drug Combinations; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D012756:Sheep / Q000502:physiology*; D013992:Tiletamine / Q000494:pharmacology*; D015041:Zolazepam / Q000494:pharmacology*
D000777:Anesthetics; D004338:Drug Combinations; C006131:tiletamine, zolazepam drug combination; D013992:Tiletamine; D015041:Zolazepam