A combined behavioral/pharmacological treatment of sleep-wake schedule disorder in Angelman syndrome.
Angelman syndrome (AS) is a genetic disorder associated with a deletion on chromosome 15. Behavior problems among children with AS include sleep difficulties. Data are presented on the successful treatment of a sleep-wake schedule disorder (SWSD) in a 9-year-old boy with AS. The treatment program included behavioral and pharmacological components. During baseline, the child slept a mean of 1.9 hours per night and 1.3 hours during the day; night sleep was increased to a mean of 8.3 hours and day sleep was reduced to a mean of .08 hours after introduction of the full-treatment program. Medication was discontinued subsequently, and the child slept a mean of 7.8 hours during the night and .07 hours during the day. At 45-day follow-up, night sleep was maintained at 7.1 hours and day sleep remained stable at .29 hours. This is the first known report of an effective treatment of a SWSD in a child with AS.
Summers
J A
JA
Department of Behavioral Psychology, Kennedy Krieger Institute, Baltimore, MD 21205.
Lynch
P S
PS
Harris
J C
JC
Burke
J C
JC
Allison
D B
DB
Sandler
L
L
D001521:Behavior Therapy; D002648:Child; D002872:Chromosome Deletion; D002884:Chromosomes, Human, Pair 15; D002940:Circadian Rhythm / Q000187:drug effects / Q000235:genetics*; D003131:Combined Modality Therapy; D004155:Diphenhydramine / Q000627:therapeutic use*; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics* / Q000523:psychology / Q000628:therapy; D008297:Male; D008831:Microcephaly / Q000235:genetics* / Q000523:psychology; D011930:Reaction Time / Q000187:drug effects; D012893:Sleep Wake Disorders / Q000235:genetics* / Q000523:psychology / Q000628:therapy
D004155:Diphenhydramine