The synergism of gamma-interferon and tumor necrosis factor in whole body hyperthermia with vitamin C to control toxicity.
In a previous paper, the synergism of gamma-interferon and tumor necrosis factor was considered with whole body hyperthermia. Because of the toxic effect of TNF due to oxygen radicals, it is suggested that vitamin C be added.
Rosen
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Hasbrouck Laboratory, University of Massachusetts, Amherst 01003.
D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D016166:Free Radical Scavengers; D006801:Humans; D006979:Hyperthermia, Induced; D007371:Interferon-gamma / Q000009:adverse effects / Q000627:therapeutic use*; D051379:Mice; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use; D014409:Tumor Necrosis Factor-alpha / Q000009:adverse effects / Q000627:therapeutic use*
D016166:Free Radical Scavengers; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma; D001205:Ascorbic Acid