title: The pathological basis of chronic renal failure in Nigerians. An autopsy study.
abstract: With the aim of determining the relative prevalence of the diseases underlying chronic renal failure (CRF) in a large homogeneous black tropical population, the autopsy records of the Obafemi Awolowo University Teaching Hospital over a four year period were studied. Out of a total of 702 cases coming to autopsy during this period, 66 (9.4%) died as a result of CRF. The highest number of cases of CRF fell within the 31-40 year age group with a male/female ratio of 1.28:1. Chronic glomerulonephritis was responsible for 40.9% of cases, malignant nephrosclerosis 16.6%, benign nephrosclerosis 7.6% while endstage renal disease (ESRD) was responsible for 15.4%. A miscellaneous group of diseases was responsible for 19.7%, about half of which was due to chronic pyelonephritis. Rarer causes of CRF were diabetic nephropathy, multiple myeloma, systemic lupus erythematosus and analgesic nephropathy.
authors.affiliation: Department of Morbid Anatomy and Forensic Medicine, Faculty of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria.
authors.forename: O S
authors.initials: OS
authors.lastname: Ojo
authors.forename: A A
authors.initials: AA
authors.lastname: Akinsola
authors.forename: S O
authors.initials: SO
authors.lastname: Nwosu
authors.forename: W O
authors.initials: WO
authors.lastname: Odesanmi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044383:Black People; D002648:Child; D002675:Child, Preschool; D006785:Hospitals, University; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007674:Kidney Diseases / Q000145:classification / Q000150:complications*; D007676:Kidney Failure, Chronic / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D015995:Prevalence; D012737:Sex Factors