title: Generation of mutant mice lacking surface expression of CD4 or CD8 by gene targeting.
abstract: With the use of homologous recombination in embryonic stem cells, two new strains of mice lacking surface CD4 or CD8 expression have been generated. It is hoped that they will be useful mouse strains for the study of autoimmune diseases, tissue transplantation rejections and tumour rejections.
authors.affiliation: Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada.
authors.forename: T W
authors.initials: TW
authors.lastname: Mak
authors.forename: A
authors.initials: A
authors.lastname: Rahemtulla
authors.forename: M
authors.initials: M
authors.lastname: Schilham
authors.forename: D R
authors.initials: DR
authors.lastname: Koh
authors.forename: W P
authors.initials: WP
authors.lastname: Fung-Leung
mesh_terms: D000818:Animals; D015704:CD4 Antigens; D016827:CD8 Antigens; D005818:Genetic Engineering; D051379:Mice; D008817:Mice, Mutant Strains / Q000276:immunology*; D011995:Recombination, Genetic; D013601:T-Lymphocytes / Q000276:immunology*; D014162:Transfection
chemical_list: D015704:CD4 Antigens; D016827:CD8 Antigens