Alterations of membrane fluidity by toxic injuries.
Alterations in membrane fluidity affect, via an effect on the ease with which proteins may change conformation, the activity of various enzymes and transport systems. Recent experiments have shown that toxic injury is frequently associated with modifications in physical state and/or lipid composition of plasma membranes. Such modifications are likely to play a role in cell dysfunction, especially in epithelial cells whose optimal function depends on the polarity in membrane fluidity between apical and basolateral domains.
Le Grimellec
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INSERM U 251, Faculté de Medecine X. Bichat Université Paris, VII.
Moll
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Artaz
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Blais
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D000818:Animals; D002462:Cell Membrane / Q000187:drug effects; D004847:Epithelial Cells; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced*; D008560:Membrane Fluidity / Q000187:drug effects*