title: [The clinical evaluation of the hypocholesterolemic effects of an inhibitor of cholesterol synthesis: mevalonic acid].
abstract: Twenty eight patients with heterozygous familial hypercholesterolemia were treated with mevalonic acid (an inhibitor of cholesterol synthesis) for 45 days. Patients received a daily dose of 750 to 1500 mg mevalonic acid depending on plasma cholesterol levels. Results showed a significant reduction in cholesterol values whereas no significant difference was observed in HDL cholesterol and triglyceride levels.
authors.affiliation: I.N.R.C.A. sede di Genova.
authors.forename: E
authors.initials: E
authors.lastname: Del Nero
authors.forename: N
authors.initials: N
authors.lastname: Aloe
authors.forename: C
authors.initials: C
authors.lastname: Augeri
authors.forename: F
authors.initials: F
authors.lastname: Avola
authors.forename: G
authors.initials: G
authors.lastname: Carta
authors.forename: A
authors.initials: A
authors.lastname: Cavagnaro
authors.forename: R
authors.initials: R
authors.lastname: De Grandi
authors.forename: M
authors.initials: M
authors.lastname: Gianfreda
authors.forename: G P
authors.initials: GP
authors.lastname: Magro
authors.forename: G P
authors.initials: GP
authors.lastname: Mazzarello
mesh_terms: D000328:Adult; D000368:Aged; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008798:Mevalonic Acid / Q000627:therapeutic use*; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
chemical_list: D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL; D014280:Triglycerides; D002784:Cholesterol; D008798:Mevalonic Acid
vernacular_title: Valutazione clinica degli effetti ipocolesterolemizzanti di un inibitore della sintesi del colesterolo: l'acido mevalonico.