title: [Participation of cytokines and immune sera to the cytoadherence of erythrocytes infected by Plasmodium falciparum on the endothelial cells in culture].
abstract: In vitro binding capacity of erythrocytes infected with P. falciparum and the modulation of cytoadherence on human endothelial cells by cytokines and sera from semi immune subjects in relation to cytoadherence were studied. Tumor necrosis factor and interleukin-3, alone or in combination with granulocyte macrophage-colony stimulating factor, enhanced in vitro cytoadherence. Contrary to pooled immune sera, patients' sera obtained during acute or convalescent phase did not reverse nor inhibit in vitro cytoadherence.
authors.affiliation: Centre National de Référence, Hôpital Bichat-Claude Bernard, Paris.
authors.forename: P
authors.initials: P
authors.lastname: Ringwald
authors.forename: J
authors.initials: J
authors.lastname: Le Bras
authors.forename: J
authors.initials: J
authors.lastname: Savel
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002478:Cells, Cultured; D016207:Cytokines / Q000494:pharmacology*; D004727:Endothelium / Q000166:cytology*; D004912:Erythrocytes / Q000166:cytology* / Q000378:metabolism / Q000469:parasitology; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology*; D010963:Plasmodium falciparum
chemical_list: D016207:Cytokines; D007106:Immune Sera
vernacular_title: Participation des cytokines et des sérums immuns à la cytoadhérence des hématies parasitées par Plasmodium falciparum sur des cellules endothéliales en culture.