title: Influence of radiotherapy on intestinal microflora in cancer patients.
abstract: We investigated in 15 patients with carcinoma of the uterine cervix or endometrium, who were undergoing postoperative radiation therapy, the effects of different fractionated radiation exposures on counts of fecal bacteria, on the growth of Clostridium difficile and Clostridium perfringens enterotoxin production. We observed a generally significant decrease in intestinal microflora after the first radiation exposure, whereas at the end of radiotherapy all bacteria increased and reached basal values except Enterococcus faecium 1, lactobacilli and total anaerobes. In some patients we observed an overgrowth of some Clostridium spp. which were potential pathogens associated with clinical symptoms. We did not observe an influence of multiple radiations on C. perfringens enterotoxin fecal contents. We conclude that patients receiving radiotherapy may benefit from the intake of oral bacteriotherapy, i.e. live beneficial bacteria such as Bacillus subtilis at the beginning of the irradiation exposure.
authors.affiliation: Institute of Pharmacology, University of Verona, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Cuzzolin
authors.forename: D
authors.initials: D
authors.lastname: Zambreri
authors.forename: M
authors.initials: M
authors.lastname: Donini
authors.forename: C
authors.initials: C
authors.lastname: Griso
authors.forename: G
authors.initials: G
authors.lastname: Benoni
mesh_terms: D000368:Aged; D016360:Clostridioides difficile / Q000528:radiation effects; D003016:Clostridium perfringens / Q000378:metabolism / Q000528:radiation effects; D016889:Endometrial Neoplasms / Q000532:radiotherapy*; D004768:Enterotoxins / Q000096:biosynthesis; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D007422:Intestines / Q000382:microbiology* / Q000528:radiation effects; D008875:Middle Aged; D011879:Radiotherapy Dosage; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy*
chemical_list: D004768:Enterotoxins