Periodic alternating esotropia.
Periodic alternating esotropia (PAE) is a rare ocular motility disturbance observed in association with periodic alternating gaze deviation (PAG) or periodic alternating nystagmus. We examined a 9-month-old developmentally delayed girl who showed PAE occurring synchronously with PAG. The ocular motility disorder consisted of rhythmic alternating fixation with the right eye in abduction, a left face turn and esotropia of the left eye (90 seconds), a changeover phase (10 to 15 seconds) during which the eyes are straight and the head is upright, then fixation with the left eye in abduction, a right face turn, and esotropia of the left eye (90 seconds). There was no spontaneous jerk nystagmus present. These findings continued incessantly during a follow-up period of 18 months. Magnetic resonance imaging revealed pronounced cerebellar vermis hypoplasia. Only three clinically similar cases have been previously reported, but none had been studied with modern neuroimaging techniques.
Hamed
L M
LM
Department of Ophthalmology, University of Florida, College of Medicine, Gainesville 32610-0284.
Silbiger
J
J
D001284:Atrophy / Q000175:diagnosis; D002526:Cerebellar Diseases / Q000175:diagnosis; D002531:Cerebellum / Q000473:pathology; D004948:Esotropia / Q000175:diagnosis*; D005260:Female; D005403:Fixation, Ocular; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D010507:Periodicity