P-aminodiphenylamine induced biochemical changes in sex organs of male albino rats.
Intraperitoneal administration of p-aminodiphenylamine (p-ADPA), an aromatic amine of wide industrial applications, / 42.5 mg/kg body weight for 180 days significantly decreased the activities of testicular lactate dehydrogenase and hyaluronidase and lactic acid content indicating arrest of spermatogenesis. Patchy necrosis of the testis was confirmed histopathologically. No change in testicular cholesterol, fructose content of coagulating glands and dorso-lateral prostate and activities of alkaline phosphatase in seminal vesicle and acid phosphatase in ventral prostate support normal androgenic status.
Singh
R L
RL
Industrial Toxicology Research Centre, Lucknow, India.
Khanna
S K
SK
Singh
G B
GB
D000818:Animals; D002784:Cholesterol / Q000032:analysis; D005837:Genitalia, Male / Q000187:drug effects* / Q000378:metabolism; D006821:Hyaluronoglucosaminidase / Q000032:analysis; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008297:Male; D010655:Phenylenediamines / Q000494:pharmacology*; D011506:Proteins / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains
D010655:Phenylenediamines; D011506:Proteins; C031506:4-aminodiphenylamine; D002784:Cholesterol; D007770:L-Lactate Dehydrogenase; D006821:Hyaluronoglucosaminidase