Hydrocortisone inhibition of human interleukin-4.
Glucocorticoids are known to inhibit mitogen-induced proliferation of T cells by suppressing the production of interleukin-2 (IL-2). These hormones have also been shown to inhibit the production of other cytokines, namely IL-1 and interferon-gamma (IFN-gamma). It is demonstrated here that hydrocortisone is able to inhibit mitogen-induced production of human IL-4, both at the secreted protein, as well as at the mRNA level. This effect may explain, in part, the immunosuppressive effects of glucocorticoids in the treatment of allergic disease.
Byron
K A
KA
Department of Biochemistry, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Varigos
G
G
Wootton
A
A
D002478:Cells, Cultured; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D066298:In Vitro Techniques; D015847:Interleukin-4 / Q000096:biosynthesis* / Q000235:genetics; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology; D012333:RNA, Messenger / Q000187:drug effects
D012333:RNA, Messenger; D015847:Interleukin-4; D006854:Hydrocortisone