title: [Effect of psychotropic drugs on the structure and function of the adrenal glands of control and stressed animals].
abstract: The purpose of the experiment was to investigate the structure and function of the rat adrenal glands under chronic stress and its correction. Chronic stress is known to cause hypertrophy of the adrenals, enlargement of the area of nuclei and width of the cortical and medullary layers, a decrease in the content and pathological distribution of phospholipids, ascorbic acid and neutral lipids reflecting the function of these glands. Preventive courses of litonit, pikamilon and, to a lesser degree, piracetam and relanium weakened or removed characteristic pathomorphological changes in the adrenal structure. Complex analysis of the extracerebral mechanisms of each drug revealed the highest preventive activity of litonit which can be used to correct the adrenal glands under chronic stress.
authors.forename: V I
authors.initials: VI
authors.lastname: Kresiun
authors.forename: Ia V
authors.initials: IaV
authors.lastname: Rozhkovskiĭ
mesh_terms: D000311:Adrenal Glands / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D002908:Chronic Disease; D006984:Hypertrophy / Q000503:physiopathology; D050356:Lipid Metabolism; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013312:Stress, Physiological / Q000473:pathology / Q000503:physiopathology*
chemical_list: D010743:Phospholipids; D011619:Psychotropic Drugs; D001205:Ascorbic Acid
vernacular_title: Osobennosti vliianiia psikhotropnykh sredstv na strukturno-funktsional'noe sostoianie nadpochechnikov intaktnykh i stressirovannykh zhivotnykh.