title: Modification of the skin feeding site by tick saliva mediates virus transmission.
abstract: A tick vector of Thogoto (THO) virus was shown to secrete a factor in saliva which potentiates the transmission of THO virus to uninfected ticks feeding on an apparently non-viraemic host. The effect of the saliva activated transmission (SAT) factor on the virus occurred at the site of inoculation in the skin and was apparent even when the virus was introduced 3 days after the SAT factor. The results suggest that tick saliva can play an important role in disease transmission by virtue of host modification at the site of feeding.
authors.affiliation: NERC Institute of Virology and Environmental Microbiology, Oxford, England.
authors.forename: L D
authors.initials: LD
authors.lastname: Jones
authors.forename: W R
authors.initials: WR
authors.lastname: Kaufman
authors.forename: P A
authors.initials: PA
authors.lastname: Nuttall
mesh_terms: D000818:Animals; D001103:Arboviruses / Q000254:growth & development*; D001179:Arthropod Vectors / Q000382:microbiology*; D002522:Chlorocebus aethiops; D005247:Feeding Behavior / Q000502:physiology; D006168:Guinea Pigs; D012463:Saliva / Q000382:microbiology / Q000502:physiology; D012867:Skin / Q000382:microbiology; D013987:Ticks / Q000382:microbiology* / Q000502:physiology; D014777:Virus Diseases / Q000635:transmission*