The postantifungal effect of 5-fluorocytosine on Candida albicans.
The in-vitro postantifungal effect (PAFE) of 5-fluorocytosine for Candida albicans for short periods of time was investigated. Yeast cells were exposed for 0.5, 1 or 2 h to a range of concentrations (0.1-3.2 mg/L) of 5-fluorocytosine. The PAFE was quantitated by determinations of the number of colony forming units at hourly intervals (0-10 h) after removal of the drug by dilution. The length of the PAFE was dependent upon the concentration of 5-fluorocytosine and the duration of exposure. An exposure time of 0.5 h resulted in PAFE's ranging from 0 to 4.2 h. Exposure times of 1 and 2 h resulted in longer PAFEs and in many instances suppression of cell growth was seen for the entire evaluation period (up to ten hours).
Scalarone
G M
GM
Department of Biological Sciences, Idaho State University, Pocatello 83209.
Mikami
Y
Y
Kurita
N
N
Yazawa
K
K
Miyaji
M
M
D002176:Candida albicans / Q000166:cytology / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D005437:Flucytosine / Q000494:pharmacology*; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D013997:Time Factors
D005437:Flucytosine