title: Body weight, hyperinsulinemia, and gonadotropin levels in the polycystic ovarian syndrome: evidence of two distinct populations.
abstract: OBJECTIVE
  To investigate the impact of body weight (BW) and insulin levels on gonadotropin and androgen levels in women with the polycystic ovarian syndrome (PCOS).
  
  
  METHODS
  Comparative study of endocrinologic parameters in PCOS women.
  
  
  METHODS
  University Hospital Reproductive Endocrinology Unit.
  
  
  METHODS
  Thirty obese and 19 nonobese women with PCOS. Seven obese and 7 nonobese normal women.
  
  
  METHODS
  Serum concentrations of insulin, testosterone, androstenedione, luteinizing hormone (LH), follicle-stimulating hormone. Serum LH response to gonadotropin-releasing hormone (GnRH) administration and assessment of insulin resistance by the continuous infusion of glucose with model assessment (CIGMA) test.
  
  
  RESULTS
  Fasting insulin levels correlated with body mass index (BMI). Basal LH levels correlated inversely with BMI. Nonobese women with PCOS had a higher LH response to GnRH than obese women with PCOS. Only obese women with PCOS showed insulin resistance and fasting hyperinsulinemia.
  
  
  CONCLUSIONS
  The data suggest that women with PCOS may be divided into two subgroups: those with obesity, insulin resistance, hyperinsulinemia, and normal/minimally elevated LH levels and those with normal BW, elevated LH levels, and normoinsulinemia.
authors.affiliation: University of Oslo, Norway.
authors.forename: P O
authors.initials: PO
authors.lastname: Dale
authors.forename: T
authors.initials: T
authors.lastname: Tanbo
authors.forename: S
authors.initials: S
authors.lastname: Vaaler
authors.forename: T
authors.initials: T
authors.lastname: Abyholm
mesh_terms: D000328:Adult; D000735:Androstenedione / Q000097:blood; D015992:Body Mass Index; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D007986:Luteinizing Hormone / Q000097:blood*; D009765:Obesity / Q000097:blood / Q000150:complications*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications*; D013739:Testosterone / Q000097:blood
chemical_list: D007328:Insulin; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D000735:Androstenedione; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone