title: Meningococcal infections: reducing the case fatality rate by giving penicillin before admission to hospital.
abstract: OBJECTIVE
  To determine whether parenteral penicillin given before admission to hospital reduces the case fatality rate in patients with meningococcal disease.
  
  
  METHODS
  Retrospective analysis of 46 consecutive patients admitted to hospital with meningococcal disease from January 1986 to March 1991.
  
  
  METHODS
  District general hospital.
  
  
  METHODS
  Hospital case fatality rate.
  
  
  RESULTS
  None of the 13 patients given parenteral penicillin by the referring doctor before admission died, compared with eight deaths (24%) in 33 patients admitted without such treatment.
  
  
  CONCLUSIONS
  Parenteral penicillin given before admission probably contributed to a reduction in the case fatality rate from meningococcal disease, and primary care physicians should be encouraged to give such treatment immediately on suspicion of the diagnosis before transferring the patient to hospital. Public health physicians are well placed to inform and alert general practitioners of the potential benefit of this action.
authors.affiliation: Memorial Hospital, Darlington.
authors.forename: J R
authors.initials: JR
authors.lastname: Strang
authors.forename: E J
authors.initials: EJ
authors.lastname: Pugh
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004739:England / Q000453:epidemiology; D005194:Family Practice / Q000193:education; D006801:Humans; D007263:Infusions, Parenteral; D008585:Meningitis, Meningococcal / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality; D008589:Meningococcal Infections / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality; D009345:Neisseria meningitidis / Q000302:isolation & purification; D010343:Patient Admission; D010406:Penicillins / Q000008:administration & dosage / Q000627:therapeutic use*; D011364:Professional Practice; D018805:Sepsis / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D010406:Penicillins