title: Effects of urethane, alphaxolone/alphadolone, or halothane with or without neuromuscular blockade on survival during repeated episodes of global cerebral ischaemia in the rat.
abstract: The effect of 4 anaesthetic regimens on blood pressure and survival was investigated during repeated episodes of cerebral ischaemia in the rat induced by diathermy of the vertebral arteries and reversible occlusion of the carotid arteries. The best results were obtained with inspired halothane with neuromuscular blockade and artificial ventilation, followed in order by halothane, intravenous alphaxolone/alphadolone, and intraperitoneal urethane with spontaneous ventilation.
authors.affiliation: Department of Physiology, University College, London, UK.
authors.forename: D S
authors.initials: DS
authors.lastname: Holder
mesh_terms: D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D001157:Arterial Occlusive Diseases / Q000209:etiology / Q000401:mortality / Q000503:physiopathology; D002545:Brain Ischemia / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology; D002340:Carotid Artery Diseases / Q000209:etiology / Q000401:mortality / Q000503:physiopathology; D004195:Disease Models, Animal; D004338:Drug Combinations; D006221:Halothane / Q000494:pharmacology; D008297:Male; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D011277:Pregnanediones / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012121:Respiration, Artificial; D012189:Retrospective Studies; D014520:Urethane / Q000494:pharmacology
chemical_list: D000777:Anesthetics; D004338:Drug Combinations; D009466:Neuromuscular Blocking Agents; D011277:Pregnanediones; D014520:Urethane; C006477:alphaxalone; C033418:alphadolone; D006221:Halothane