Fetotoxic response of technical quinalphos in rats.
Technical Quinalphos was administered po to pregnant rats through day 6-20 of gestation at doses of 0.5 or 1.5 mg/kg body weight. Quinalphos produced enzymatic changes in liver and serum of dams associated with mild pathomorphological changes in liver and brain. Fetotoxic effects were not observed at the tested dose levels as determined by total number of implantations, percentage resorption, live fetuses, crown rump length and fetal weight. A few insignificant skeletal deformities were noticed. A significant inhibition of acetylcholinesterase activity in fetal brain and placenta indicated possible transmigration of quinalphos from dams to fetuses.
Srivastava
M K
MK
Pesticide Toxicology Division, Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India.
Raizada
R B
RB
Dikshith
T S
TS
D000014:Abnormalities, Drug-Induced; D000110:Acetylcholinesterase / Q000032:analysis / Q000097:blood; D000410:Alanine Transaminase / Q000032:analysis / Q000097:blood; D000469:Alkaline Phosphatase / Q000032:analysis / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000032:analysis / Q000097:blood; D001921:Brain / Q000201:enzymology; D004305:Dose-Response Relationship, Drug; D005314:Embryonic and Fetal Development / Q000187:drug effects; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005333:Fetus / Q000187:drug effects*; D007306:Insecticides / Q000633:toxicity*; D007770:L-Lactate Dehydrogenase / Q000032:analysis / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D009946:Organothiophosphorus Compounds / Q000633:toxicity*; D010920:Placenta / Q000201:enzymology; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D007306:Insecticides; D009946:Organothiophosphorus Compounds; C009145:quinalphos; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000110:Acetylcholinesterase; D000469:Alkaline Phosphatase