Pituitary adenylate cyclase activating polypeptide (PACAP) reduces food intake in mice.
Pituitary adenylate cyclase activating peptide (PACAP) is a peptide that is present in the hypothalamus and other areas of the rat brain. This study demonstrates that PACAP reduces food intake after intracerebroventricular injection in food-deprived mice. Behavioral analysis suggests that this decrease in food intake is, in part, compensated for by an increase in other behaviors. Pituitary adenylate cyclase activating peptide also was demonstrated to antagonize increased food intake resulting from administration of neuropeptide Y. Thus, PACAP joins a growing list of neuropeptides involved in the central regulation of food intake.
Morley
J E
JE
Geriatric Research Education and Clinical Center (GRECC), VA Medical Center, St. Louis, MO 63125.
Horowitz
M
M
Morley
P M
PM
Flood
J F
JF
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004435:Eating / Q000187:drug effects*; D005508:Food Deprivation / Q000502:physiology; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D009478:Neuropeptide Y / Q000494:pharmacology; D009479:Neuropeptides / Q000494:pharmacology*; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide
C495402:Adcyap1 protein, mouse; D009478:Neuropeptide Y; D009479:Neuropeptides; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide