An activity which restores theta toxin activity in some theta toxin-deficient mutants of Clostridium perfringens.
Group a mutants of Clostridium perfringens are deficient in theta toxin but release a dialyzable substance ("substance A"), which restores theta toxin activity to group b mutants, into a culture supernatant; group b mutants are defective in "substance A" release. "Substance A" activity appeared in the exponentially growing phase of group a mutants and disappeared in the stationary phase. "Substance A" activity was most stable at pH 5.0 and 0 C and even increased threefold in the first 5 hr, but gradually decreased during the following 15 hr. It was quickly inactivated at neutral and higher pHs at 0 C.
Imagawa
T
T
Department of Bacteriology, Osaka University Medical School, Japan.
Higashi
Y
Y
D001426:Bacterial Proteins / Q000378:metabolism; D001427:Bacterial Toxins / Q000235:genetics / Q000378:metabolism*; D003016:Clostridium perfringens / Q000235:genetics / Q000378:metabolism*; D003470:Culture Media; D006460:Hemolysin Proteins / Q000235:genetics / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics
D001426:Bacterial Proteins; D001427:Bacterial Toxins; D003470:Culture Media; D006460:Hemolysin Proteins; C020452:Clostridium perfringens theta-toxin