[A rapid method of evaluation of the effectiveness of antibacterial drugs].
Efficacy of antibiotics in the treatment of experimental tularemia was studied comparatively on various biological models. It was shown that the antibiotics which proved active against the tularemia microbe in albino mice when studied by the rapid and routine methods were highly efficient in the treatment and prevention of experimental tularemia in rabbits and baboons (hamadryas). The experiments showed basic possibilities to perform rapid estimation (for at least 2 days) of drug efficacy in experimental glanders and melioidosis in golden hamsters. The rapid method developed by the authors was recommended for the use in primary estimation of the efficacy of new drugs in the treatment of tularemia, glanders and melioidosis.
Oborin
V A
VA
Kravets
I D
ID
Vasil'ev
N T
NT
Vasil'ev
P G
PG
Kornilov
M N
MN
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D006224:Cricetinae; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D005896:Glanders / Q000188:drug therapy* / Q000401:mortality; D008554:Melioidosis / Q000188:drug therapy* / Q000401:mortality; D008647:Mesocricetus; D051379:Mice; D010215:Papio; D011817:Rabbits; D013045:Species Specificity; D013997:Time Factors; D014406:Tularemia / Q000188:drug therapy* / Q000401:mortality
D000900:Anti-Bacterial Agents
Uskorennyĭ metod otsenki éffektivnosti antibakterial'nykh lekarstvennykh preparatov.