[The effect of thyroid- and sex hormones on triglyceride secretion in rat liver].
The influence of thyroxine, estradiol and testosterone on the triacylglycerol (TG) secretion rate out of the liver into the blood as well as on concentrations of FFA, triglycerides, and glucose in serum was determined. All of these experiments were carried out under different nutritional conditions (non-fasting, and 10 or 16 h fasting, respectively). Accordingly the results after hormone application were compared with three groups of controls. Within these control groups increasing time of fasting caused exclusively an enhancement of FFA concentrations, while the TG secretion rate and other parameters were not influenced. Concerning all hormones effects on several lipid parameters have been observed. In particular, a decrease of FFA concentrations in comparison with controls after 16 h fasting was evident. In these cases, the TG secretion rate and TG concentration in serum were simultaneously lowered. Both alterations may be a consequence of a diminished mobilization of FFA in adipose tissue. Increases of FFA concentrations in serum after hormone application, compared with the corresponding controls, only occurred after administration of thyroxine and testosterone, while changes of the TG secretion rate and the TG concentration in serum were scarcely observed. Final remarks about the actual influence of hormones on the investigated parameters, especially TG secretion rate were drawn including results of a previous paper, where catecholamines, insulin, and prednisolone had been tested under the same conditions.
Haude
W
W
Institut für Pathologische und Klinische Biochemie, Ernst-Moritz-Arndt-Universität Greifswald, Bundesrepublik Deutschland.
Völcker
C E
CE
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D004958:Estradiol / Q000494:pharmacology; D005230:Fatty Acids, Nonesterified / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000494:pharmacology; D013963:Thyroid Hormones / Q000494:pharmacology*; D013972:Thyrotropin / Q000494:pharmacology; D013974:Thyroxine / Q000494:pharmacology; D014280:Triglycerides / Q000378:metabolism*
D005230:Fatty Acids, Nonesterified; D012739:Gonadal Steroid Hormones; D013963:Thyroid Hormones; D014280:Triglycerides; D013739:Testosterone; D004958:Estradiol; D013972:Thyrotropin; D013974:Thyroxine
Der Einfluss von Schilddrüsen- und Sexualhormonen auf die Triglyceridsekretion der Rattenleber.