[Clinical effectiveness and potential hazards of combined kordaron and quinidine therapy of patients with atrial fibrillation].
Clinical efficacy of and potential risk for complications from combined cordarone+quinidine treatment were studied in 52 patients with atrial fibrillation (AF). Out of 32 patients with a persistent pattern of the disease the sinus rhythm was recovered in 28 (87.5%) of the patients; out of 20 patients with paroxysmal pattern of AF resistant to routine anti-arrhythmic treatment, the sinus rhythm was recovered in 14 (70%) patients. Almost 50% Q-T prolongation was recorded in one patient with paroxysmal AF. Despite the withdrawal of the medication, 4 hours later ventricular tachycardia of the "pirouette" type arose that 2-3 minutes later was followed by ventricular fibrillation with clinical death. After effective electric defibrillation in the presence of lidocaine treatment ventricular fibrillation repeated 7 times. A total of 32 cardiac defibrillations were performed for 6 hours. The normalization of the Q-T interval was observed on the fourth day only. The patient was discharged from the hospital in a satisfactory condition.
Lipnitskiĭ
T N
TN
Dorogan
A V
AV
Randin
A G
AG
Kotsuta
G I
GI
D000328:Adult; D000368:Aged; D000638:Amiodarone / Q000008:administration & dosage* / Q000009:adverse effects; D001281:Atrial Fibrillation / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D004554:Electric Countershock; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000187:drug effects*; D006801:Humans; D008012:Lidocaine / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011802:Quinidine / Q000008:administration & dosage* / Q000009:adverse effects; D014693:Ventricular Fibrillation / Q000139:chemically induced
D008012:Lidocaine; D011802:Quinidine; D000638:Amiodarone
Klinicheskaia éffektivnost' i potentsial'nyĭ risk kombinirovannoĭ terapii kordaronom i khinidinom bol'nykh mertsiatel'noĭ aritmieĭ.