title: Effect of dietary nitrate on endogenous nitrosation of piperazine in humans.
abstract: The effect of dietary nitrate on endogenous nitrosation of a therapeutic dose of piperazine has been described in five human volunteers who acted as their own controls. The urinary excretion of endogenously formed N-nitro-somonopiperazine (MNPz) ranged between 9.2 and 80.1 micrograms/24 h on a normal uncontrolled diet which increased from 25.7 to 163.7 micrograms/24 h when the diet was supplemented with 250 mg nitrate. The corresponding urinary nitrate was 63.0-122.7 mg/24 h and 119.2-322.0 mg/24 h, respectively. The dinitroso derivative of piperazine was detected only in trace amounts and no detectable increase in its excretion was observed during high nitrate exposure. The unchanged piperazine (range 294-784 mg/24 h) in urine showed a decrease under high nitrate regimen (range 185-399 mg/24 h).
authors.affiliation: Department of Pharmaceutical Sciences, University of Kashmir, India.
authors.forename: R
authors.initials: R
authors.lastname: Kumar
authors.forename: M
authors.initials: M
authors.lastname: Siddiqi
authors.forename: Z
authors.initials: Z
authors.lastname: Fazili
authors.forename: C D
authors.initials: CD
authors.lastname: Wacker
authors.forename: B
authors.initials: B
authors.lastname: Spiegelhalder
authors.forename: R
authors.initials: R
authors.lastname: Preussmann
mesh_terms: D002273:Carcinogens / Q000032:analysis*; D004032:Diet; D006801:Humans; D009566:Nitrates / Q000378:metabolism* / Q000652:urine; D009602:Nitrosamines / Q000652:urine*; D000077489:Piperazine; D010879:Piperazines / Q000378:metabolism* / Q000652:urine
chemical_list: D002273:Carcinogens; D009566:Nitrates; D009602:Nitrosamines; D010879:Piperazines; D000077489:Piperazine; C014711:1-nitrosopiperazine