title: Gastric carcinoma in young Hong Kong Chinese.
abstract: Gastric carcinomas usually occur in older people. Those occurring in the young are uncommon. The pathological and clinical features of gastric carcinomas were reviewed in 42 Chinese patients who were 35 years of age and younger. The data were obtained from the record files of the University Department of Pathology, Queen Mary Hospital for the period 1976-85. The patients comprised 4% of the total cases of gastric carcinomas in that period. These patients (age range: 20-35 years, mean: 30 years) showed a male to female ratio of 1:2.5 which differs from the usual male preponderance seen in gastric carcinoma. Among the 27 cases with known staging, 22 (81.5%) were stage III or IV. Twenty-five cases had an ulcerative appearance. All were adenocarcinomas and the majority (83.3%) were poorly differentiated. Associated dysplasia was found in 35 (83.3%) cases, although only 14 of these were in association with poorly differentiated adenocarcinomas. Intestinal metaplasia was found in 13 cases and, when present, involved less than 30% of the mucosa. Only two cases were of type III metaplasia. The findings show that gastric carcinoma in young Chinese tended to occur more frequently in females, presented at late stages, showed poor glandular differentiation, was frequently associated with gastric dysplasia and had minimal association with intestinal metaplasia.
authors.affiliation: Department of Pathology, University of Hong Kong, Queen Mary Hospital.
authors.forename: A N
authors.initials: AN
authors.lastname: Cheung
authors.forename: U S
authors.initials: US
authors.lastname: Khoo
authors.forename: I O
authors.initials: IO
authors.lastname: Ng
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000328:Adult; D000367:Age Factors; D005260:Female; D006723:Hong Kong; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D012737:Sex Factors; D013274:Stomach Neoplasms / Q000473:pathology*