Effect of iron on serum 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D concentrations.
In 13 of 17 infants (aged 10.5 +/- 4.3; mean +/- SD mo) with iron-deficiency anemia, the serum 24,25-dihydroxyvitamin D concentration was below the normal range and in 9 of these 13 the serum 25-hydroxyvitamin D concentration was below the normal range despite the fact that these infants received 10 micrograms vitamin D/d from the age of 1 mo. The infants were treated with intramuscular iron dextran (Imferon). The iron-dextran treatment increased the hemoglobin and serum iron concentrations as well as 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D concentrations. It is known that iron deficiency impairs fat and vitamin A intestinal absorption. Therefore, it is suggested that absorption of vitamin D may also be impaired. This may contribute to the development of vitamin D deficiency. Iron supplementation may have improved the absorption of vitamin D in the small intestine and hence increased the vitamin D concentration in the plasma.
Heldenberg
D
D
Department of Pediatrics, Hillel-Yaffe Memorial Hospital, Hadera, Israel.
Tenenbaum
G
G
Weisman
Y
Y
D015652:25-Hydroxyvitamin D 2 / Q000097:blood* / Q000172:deficiency; D000747:Anemia, Hypochromic / Q000097:blood* / Q000453:epidemiology; D004872:Ergocalciferols / Q000097:blood* / Q000172:deficiency; D006801:Humans; D007223:Infant; D007557:Israel / Q000453:epidemiology; D015995:Prevalence; D014808:Vitamin D Deficiency / Q000097:blood* / Q000453:epidemiology
D004872:Ergocalciferols; D015652:25-Hydroxyvitamin D 2; C028140:24,25-dihydroxyvitamin D2