title: Cell targeting by murine recombinant retroviruses.
abstract: Cell targeting by murine retroviruses carrying recombinant genes would have numerous applications such as immortalization of under-represented cell types from complex cellular mixtures, increasing therapeutical yields in the case of gene therapy and delivery of specific genes at any location and at any moment of the life-time of living animals. To this aim, we are currently developing techniques that allow binding of viral particles to specific cell membrane markers different from the natural receptors. We have shown that biochemical bi-specific molecular adaptors able to bind both viral particles and cell surface molecules may reveal appropriate for piloting viruses toward specific cell types. More recently, we have undertaken the genetic engineering of the retroviral envelope glycoprotein in order to modify its natural tropism. This approach is discussed below.
authors.affiliation: Laboratoire de Biologie Moléculaire, URA CNRS 1191, Génétique Moléculaire, USTL, Montpellier, France.
authors.forename: M
authors.initials: M
authors.lastname: Etienne-Julan
authors.forename: P
authors.initials: P
authors.lastname: Roux
authors.forename: P
authors.initials: P
authors.lastname: Bourquard
authors.forename: S
authors.initials: S
authors.lastname: Carillo
authors.forename: P
authors.initials: P
authors.lastname: Jeanteur
authors.forename: M
authors.initials: M
authors.lastname: Piechaczyk
mesh_terms: D003673:Defective Viruses / Q000235:genetics* / Q000378:metabolism; D015686:Gene Products, env / Q000378:metabolism; D015752:Genes, env; D005818:Genetic Engineering; D005822:Genetic Vectors; D006367:HeLa Cells / Q000378:metabolism; D006801:Humans; D008979:Moloney murine leukemia virus / Q000235:genetics* / Q000378:metabolism; D011991:Receptors, Virus / Q000378:metabolism; D015682:Retroviridae Proteins, Oncogenic / Q000235:genetics / Q000378:metabolism; D014162:Transfection; D014759:Viral Envelope Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D015686:Gene Products, env; D011991:Receptors, Virus; D015682:Retroviridae Proteins, Oncogenic; D014759:Viral Envelope Proteins