Ofloxacin versus doxycycline for treatment of cervical infection with Chlamydia trachomatis.
Women with culture-proven Chlamydia trachomatis cervical infection were randomized to receive either ofloxacin (300 mg) or doxycycline (100 mg), orally twice daily for 7 days. All 56 had negative cultures 5 to 9 days after treatment. Four weeks after treatment, 26 (93%) of 28 ofloxacin-treated patients and all 22 doxycycline-treated patients were cured. We conclude that 300 mg of ofloxacin given twice daily for 7 days provides effective therapy for chlamydial infection of the cervix.
Hooton
T M
TM
Department of Medicine, University of Washington School of Medicine, Harborview Medical Center, Seattle 98104.
Batteiger
B E
BE
Judson
F N
FN
Spruance
S L
SL
Stamm
W E
WE
D002690:Chlamydia Infections / Q000188:drug therapy*; D002692:Chlamydia trachomatis; D004318:Doxycycline / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015242:Ofloxacin / Q000627:therapeutic use*; D011897:Random Allocation; D002577:Uterine Cervical Diseases / Q000188:drug therapy
D015242:Ofloxacin; D004318:Doxycycline