title: In vivo comparison of the biocompatibility of two root canal sealers implanted into the mandibular bone of rabbits.
abstract: The purpose of this study was to evaluate the in vivo biocompatibility of two zinc oxide-eugenol-based sealers, Sealite and Pulp Canal Sealer, after implantation into the mandibular bone of rabbits. Thirty female New-Zealand rabbits were randomly divided into three groups on the basis of the material to be implanted in each side of the mandible: six rabbits received a positive control implant (silicone tubes filled with asbestos) in both sides of the mandible; 12 rabbits received a Sealite implant in the left side and a negative control implant (silicone tubes filled with silicone adhesive) in the right side of the mandible; and 12 rabbits received a silicone tube filled with Pulp Canal Sealer in the left side and a negative control implant in the right side of the mandible. The sealers were implanted in a freshly mixed, unset state. The rabbits were killed 4 or 12 weeks after implantation and the implants and surrounding bone were sectioned and treated in accord with standard histologic procedures. The tissue reactions were scored and rated as none, very slight, slight, moderate, severe, and very severe. The statistical analysis of the data showed that the two sealers had similar, good biocompatibility, and that the reactions observed at the 12-week period were better than those observed at the 4-week period. Both sealers may be used indifferently in routine endodontic practice.
authors.affiliation: Unité Interface Matrice Extra-cellulaire Biomatériaux, Universite d'Aix-Marseille Il-U.F.R. d'Odontologie, France.
authors.forename: W J
authors.initials: WJ
authors.lastname: Pertot
authors.forename: J
authors.initials: J
authors.lastname: Camps
authors.forename: M
authors.initials: M
authors.lastname: Remusat
authors.forename: J P
authors.initials: JP
authors.lastname: Proust
mesh_terms: D000539:Alveolar Process / Q000187:drug effects; D000818:Animals; D001672:Biocompatible Materials; D001853:Bone Marrow / Q000187:drug effects; D005260:Female; D008422:Materials Testing; D010521:Periosteum / Q000187:drug effects; D011817:Rabbits; D012387:Root Canal Filling Materials / Q000633:toxicity*; D015035:Zinc Oxide-Eugenol Cement / Q000633:toxicity
chemical_list: D001672:Biocompatible Materials; D012387:Root Canal Filling Materials; D015035:Zinc Oxide-Eugenol Cement; C071465:sealite; C076543:Kerr Pulp Canal Sealer