Human platelets in synovial fluid. A focus on the effects of growth factors on the inflammatory responses in rheumatoid arthritis.
The alpha granules of platelets are a major storage site for peptide growth factors. The inflamed synovial fluid of rheumatoid arthritis contains a high number of platelets as well as platelet-derived growth factors. These platelets may apparently be acted upon to release their alpha granule-located substances. It can thus be suggested that platelets present in the synovial fluid express growth factors of significance to the local inflammatory responses of rheumatoid arthritis.
Endresen
G K
GK
Oslo Sanitetsforening Rheumatism Hospital, Norway.
Førre
O
O
D001172:Arthritis, Rheumatoid / Q000378:metabolism / Q000503:physiopathology*; D001792:Blood Platelets / Q000737:chemistry / Q000378:metabolism*; D006133:Growth Substances / Q000032:analysis / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D010982:Platelet-Derived Growth Factor / Q000032:analysis / Q000378:metabolism / Q000502:physiology; D013582:Synovial Fluid / Q000737:chemistry / Q000166:cytology*
D006133:Growth Substances; D010982:Platelet-Derived Growth Factor