title: Primary adult T-cell lymphoma of the breast.
abstract: A case of primary adult T-cell lymphoma (ATL) of the breast is described. A 69-year-old woman presented with a painless, rapidly growing lump in her left breast. Staging procedures demonstrated no sign of generalized disease. Following a Patey's mastectomy, 10 courses of adjuvant chemotherapy (CHOP) were successfully administered. The light microscopic, immunohistochemical and molecular genetic analyses of the surgical specimen revealed a primary ATL. Seropositive mothers who breast-feed their children may facilitate the accumulation of T cells carrying HTLV-I in their breasts and thereby increase their risks of developing breast ATL.
authors.affiliation: First Department of Internal Medicine, University of Tokushima, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kosaka
authors.forename: N
authors.initials: N
authors.lastname: Tsuchihashi
authors.forename: M
authors.initials: M
authors.lastname: Takishita
authors.forename: Y
authors.initials: Y
authors.lastname: Miyamoto
authors.forename: K
authors.initials: K
authors.lastname: Okagawa
authors.forename: T
authors.initials: T
authors.lastname: Gotoh
authors.forename: S
authors.initials: S
authors.lastname: Saito
authors.forename: M
authors.initials: M
authors.lastname: Komaki
authors.forename: T
authors.initials: T
authors.lastname: Morimoto
authors.forename: T
authors.initials: T
authors.lastname: Sano
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015139:Blotting, Southern; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D015481:HTLV-I Antibodies / Q000097:blood; D006801:Humans; D007150:Immunohistochemistry; D016399:Lymphoma, T-Cell / Q000175:diagnosis* / Q000628:therapy; D008327:Mammography; D015411:Mastectomy, Modified Radical; D016217:Ultrasonography, Mammary
chemical_list: D004273:DNA, Neoplasm; D015481:HTLV-I Antibodies