title: [Inhibition of the tumoral growth induced by the injection of histo-incompatible cells producing interleukin-2].
abstract: In murine models, we show that the growth of a transplanted tumor can be controlled when allogeneic or xenogeneic cells expressing high levels of interleukin-2 are co-injected with the syngeneic tumor cells. Thus, genetically modified allogeneic or xenogeneic cells could have some therapeutic potential as vectors for transient cytokine gene expression.
authors.affiliation: Unité de Biologie moléculaire du Gène, U. 277 I.N.S.E.R.M., Institut Pasteur, Paris.
authors.forename: C
authors.initials: C
authors.lastname: Roth
authors.forename: L M
authors.initials: LM
authors.lastname: Mir
authors.forename: M
authors.initials: M
authors.lastname: Cressent
authors.forename: F
authors.initials: F
authors.lastname: Quintin-Colonna
authors.forename: J
authors.initials: J
authors.lastname: Belehradek
authors.forename: V
authors.initials: V
authors.lastname: Ley
authors.forename: D
authors.initials: D
authors.lastname: Fradelizi
authors.forename: P
authors.initials: P
authors.lastname: Kourilsky
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D007376:Interleukin-2 / Q000032:analysis / Q000494:pharmacology*; D008175:Lung Neoplasms / Q000473:pathology; D012515:Mast-Cell Sarcoma / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation / Q000473:pathology*; D012513:Sarcoma, Experimental / Q000473:pathology
chemical_list: D007376:Interleukin-2
vernacular_title: Inhibition de la croissance tumorale induite par l'injection de cellules histo-incompatibles produisant de l'interleukine-2.