[Azoles. 34. Nitroimidazole derivatives and their antibacterial and fungicidal action].
Nitroimidazole derivatives 4a-4c, 5a-5c, 8a-8c and 9a-9c were synthesized by treating 4,5-dinitro- and 2-methyl-4,5-dinitroimidazole (1,2) or their silver salts [1.Ag,, 2.Ag) with chlorosubtituted phenacyl bromides 3a-3c, diethyl sulphate or ethyl iodide, allyl iodide and ethyl chloro-, azo- or bromoacetate. 2,4(5)-dinitroimidazole (10) has been converted to the 2,4-dinitroimidazole derivative 10a by the action of ethyl bromoacetate in the presence of sodium ethylate. A modified method for the synthesis of 6a and 6b has been described. 7a and 7b have been obtained by a known method. Some of the newly synthesized nitroimidazole derivatives show antibacterial and fungicidal activity.
Zaprutko
L
L
Lehrstuhl für Organische Chemie, Karol Marcinkowski Medizinischen Akademie Poznań, Polen.
Wrzeciono
U
U
Gajdziński
M
M
Bartkowiak
M
M
Lutomski
K
K
Michalska
W
W
Pietkiewicz
K
K
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001393:Azoles / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D005659:Fungicides, Industrial / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009593:Nitroimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001393:Azoles; D005659:Fungicides, Industrial; D009593:Nitroimidazoles
Azole. 34. Mitteilung4: Uber Nitroimidazolderivate und ihre antibakterielle und fungizide Wirkung.