title: The influence of age on treatment choice and survival of elderly breast cancer patients in south-eastern Netherlands: a population-based study.
abstract: The influence of age on treatment choice and survival was studied in 2268 breast cancer patients of 55 years and older reported to the Eindhoven Cancer Registry from 1975 to 1987. Among patients of 75 years and older, stage I and II tumours occurred less often, whereas stage IIIb and undefined tumours occurred more often than among younger patients. Physicians were found to be less likely to treat women of 75 years and older with adjuvant radiotherapy after a mastectomy. Instead, these women received either surgery alone or surgery followed by hormonal therapy. Surgical procedures in the oldest age group were also less extensive. The 10-year relative survival for women over 74 years (32%) was significantly worse than that for younger patients (57%). Multivariate analyses showed that this poor outcome for the oldest age group was largely related to their unfavourable stage distribution: stage-specific survival appeared to be similar in all age groups. Age-related differences in treatment did not have an effect on survival.
authors.affiliation: Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam.
authors.forename: L
authors.initials: L
authors.lastname: Bergman
authors.forename: H M
authors.initials: HM
authors.lastname: Kluck
authors.forename: F E
authors.initials: FE
authors.lastname: van Leeuwen
authors.forename: M A
authors.initials: MA
authors.lastname: Crommelin
authors.forename: G
authors.initials: G
authors.lastname: Dekker
authors.forename: A A
authors.initials: AA
authors.lastname: Hart
authors.forename: J W
authors.initials: JW
authors.lastname: Coebergh
mesh_terms: D000367:Age Factors; D000368:Aged; D001943:Breast Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D009426:Netherlands / Q000453:epidemiology; D015996:Survival Rate