title: [Curling and kinking of hair caused by etretinate].
abstract: In two female psoriasis patients, curling and kinking of the scalp hair developed subsequent to a long-term etretinate therapy. Scanning electron microscopic examination of kinking hair revealed twists with sharp-edged defects and splitting of the cuticle cells in several hairshafts. The quantitative determination of the mechanical parameters of these hairs using a computerized system revealed statistically significant changes from the pattern in the scalp hair of untreated psoriasis patients. This finding suggests etretinate-induced alteration of the expression of the psoriatic phenotype in the keratin composition of hair in psoriasis patients.
authors.affiliation: Abteilung Dermatologie I, Universitäts-Hautklinik Göttingen.
authors.forename: S
authors.initials: S
authors.lastname: Schauder
authors.forename: D
authors.initials: D
authors.lastname: Tsambaos
authors.forename: G
authors.initials: G
authors.lastname: Nikiforidis
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D005050:Etretinate / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006197:Hair / Q000187:drug effects* / Q000473:pathology; D006201:Hair Diseases / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008134:Long-Term Care; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology
chemical_list: D005050:Etretinate
vernacular_title: Lockenbildung und Kräuselung der Haare durch Etretinat.