Toxicologic evaluation of the new cyclosporin derivative, SDZ IMM 125, in a comparative, subchronic toxicity study in rats.
Donatsch
P
P
Preclinical Research, Sandoz Pharma, Ltd, Basel, Switzerland.
Mason
J
J
Richardson
B P
BP
Ryffel
B
B
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001682:Biological Availability; D001774:Blood Chemical Analysis; D001835:Body Weight / Q000187:drug effects; D016572:Cyclosporine / Q000493:pharmacokinetics / Q000494:pharmacology / Q000633:toxicity; D003524:Cyclosporins / Q000493:pharmacokinetics / Q000494:pharmacology / Q000633:toxicity*; D003643:Death; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000633:toxicity*; D007668:Kidney / Q000033:anatomy & histology / Q000502:physiology; D008099:Liver / Q000033:anatomy & histology / Q000502:physiology; D008297:Male; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D013950:Thymus Gland / Q000033:anatomy & histology; D000637:Transaminases / Q000097:blood
D003524:Cyclosporins; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D000637:Transaminases; D000469:Alkaline Phosphatase; C075935:SDZ IMM 125