title: Efficacy of dapsone with pyrimethamine (Maloprim) for malaria prophylaxis in Maputo, Mozambique.
abstract: In a randomized controlled study of malaria prophylaxis, dapsone-pyrimethamine at a weekly dosage of dapsone 50-100 mg with pyrimethamine 6.25-12.5 mg or placebo was administered to 166 school children for 17 weeks. Fortnightly parasitological controls revealed 28 infections in the placebo group and none in the dapsone-pyrimethamine group. It is concluded that weekly dapsone-pyrimethamine is effective for the prophylaxis of falciparum malaria in Mozambique.
authors.affiliation: Sector de Malaria, Instituto Nacional de Saude, Maputo, Mozambique.
authors.forename: J
authors.initials: J
authors.lastname: Pividal
authors.forename: V
authors.initials: V
authors.lastname: Viktinski
authors.forename: E
authors.initials: E
authors.lastname: Streat
authors.forename: A
authors.initials: A
authors.lastname: Schapira
mesh_terms: D002648:Child; D003622:Dapsone / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D016778:Malaria, Falciparum / Q000469:parasitology / Q000517:prevention & control*; D009073:Mozambique; D011739:Pyrimethamine / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D003622:Dapsone; D011739:Pyrimethamine