title: Flash and pattern reversal visual evoked responses in normal and demented elderly.
abstract: P1 and P2 components of visual evoked responses (VERs) to flash stimuli were compared between patients diagnosed as suffering from Senile Dementia of the Alzheimer Type (AD) and elderly controls. Additionally the P100 component of the VER to pattern reversal stimuli at high and low contrast and using large and small check patterns was compared. Significant differences between moderate AD patients and the normal elderly were found for the P2 component of the flash stimulus and for the P100 component of the high spatial frequency pattern reversal stimuli at low contrast. These findings suggest a deficit in primary visual processing and a selective deficit in secondary visual processing in moderate cases of dementia. This indicates that visual processing capacities of AD patients decline as the disease progresses in line with the continual degeneration of neuronal populations involved with vision.
authors.affiliation: Wellcome Neuroscience Group, University of Glasgow.
authors.forename: E E
authors.initials: EE
authors.lastname: Brodie
authors.forename: D
authors.initials: D
authors.lastname: Allan
authors.forename: D N
authors.initials: DN
authors.lastname: Brooks
authors.forename: J
authors.initials: J
authors.lastname: McCulloch
authors.forename: W S
authors.initials: WS
authors.lastname: Foulds
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000503:physiopathology / Q000523:psychology; D003704:Dementia / Q000503:physiopathology* / Q000523:psychology; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D006801:Humans; D010775:Photic Stimulation