title: The expression and localization of mRNA for colony-stimulating factor (CSF)-1 in human term placenta.
abstract: A 4-kb mRNA for colony-stimulating factor 1 (CSF-1) was detected in normal human placenta at term by Northern blot analysis. In-situ hybridization revealed that the mRNA for CSF-1 was localized in the mesenchymal cells of the chorionic villous stroma, but not in the trophoblasts or capillary epithelial cells. Because there are significant numbers of tissue macrophages (Hofbauer cells) in the placental stroma and because the receptor for CSF-1 (the c-fms proto-oncogene product) is known to be expressed by trophoblasts, our results suggest that CSF-1 produced by placental stromal cells may act as a growth and survival factor for human placental macrophages and trophoblasts.
authors.affiliation: Department of Gynaecology and Obstetrics, Faculty of Medicine, Kyoto University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kanzaki
authors.forename: J
authors.initials: J
authors.lastname: Yui
authors.forename: M
authors.initials: M
authors.lastname: Iwai
authors.forename: K
authors.initials: K
authors.lastname: Imai
authors.forename: M
authors.initials: M
authors.lastname: Kariya
authors.forename: H
authors.initials: H
authors.lastname: Hatayama
authors.forename: T
authors.initials: T
authors.lastname: Mori
authors.forename: L J
authors.initials: LJ
authors.lastname: Guilbert
authors.forename: T G
authors.initials: TG
authors.lastname: Wegmann
mesh_terms: D001345:Autoradiography; D015152:Blotting, Northern; D002196:Capillaries / Q000166:cytology; D002824:Chorionic Villi / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism; D006801:Humans; D016173:Macrophage Colony-Stimulating Factor / Q000096:biosynthesis / Q000235:genetics*; D008648:Mesoderm / Q000378:metabolism; D009693:Nucleic Acid Hybridization; D010920:Placenta / Q000378:metabolism*; D000090063:Proto-Oncogene Mas; D012333:RNA, Messenger / Q000096:biosynthesis*; D014327:Trophoblasts / Q000378:metabolism
chemical_list: C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D012333:RNA, Messenger; D016173:Macrophage Colony-Stimulating Factor