title: Interference with ovulation and luteal function by human ovarian follicular fluid peptide in bonnet monkeys, Macaca radiata.
abstract: Partially purified human ovarian follicular fluid peptide (hGF2) was administered during follicular phase in 5 bonnet monkeys. In control as well as hGF2-injected animals, ovulation was synchronized by treatment with FSH, Pergonal and hCG. All the 5 control bonnet monkeys showed plasma estradiol peak followed by increased progesterone levels. In 4 out of 5 hGF2-injected animals, plasma progesterone levels were drastically reduced. Plasma estradiol levels were decreased only in 3 animals in which amenorrhea was observed. These data reveal that hGF2 injection disrupted ovarian function in bonnet monkeys.
authors.affiliation: Institute for Research in Reproduction, Parel, Bombay, India.
authors.forename: T D
authors.initials: TD
authors.lastname: Nandedkar
authors.forename: J K
authors.initials: JK
authors.lastname: Shahid
authors.forename: S D
authors.initials: SD
authors.lastname: Kholkute
authors.forename: M B
authors.initials: MB
authors.lastname: Darpe
authors.forename: S B
authors.initials: SB
authors.lastname: Moodbidri
mesh_terms: D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects*; D004958:Estradiol / Q000097:blood; D005260:Female; D007273:Injections, Intramuscular; D036341:Intercellular Signaling Peptides and Proteins; D008255:Macaca radiata; D008597:Menstrual Cycle / Q000187:drug effects; D010060:Ovulation / Q000187:drug effects*; D010455:Peptides / Q000494:pharmacology*; D011374:Progesterone / Q000097:blood
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C018355:intraovarian peptides; D011374:Progesterone; D004958:Estradiol