[Effect of immunomodulators of various origin on the histamine-sensitizing activity of whole-cell pertussis vaccine].
Changes in the histamine-sensitizing activity of whole-cell pertussis vaccine (PV) under the action of immunomodulators (IM) of bacterial (peptide and peptidoglycans), synthetic (peptidoglycan) and vegetable origin have been studied. The study has revealed that these IM, introduced orally and parenterally, exhibit histamine-sensitizing activity, depending on the nature of IM and the optimum selection of the doses of IM and PV.
Zakharova
N S
NS
Shepeleva
I B
IB
Britsina
M V
MV
Vlasov
G S
GS
Kalina
N G
NG
Elkina
S I
SI
Remova
T N
TN
Ermolova
E V
EV
Bazhanova
I G
IG
Savranskaia
S Ia
SIa
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D004347:Drug Interactions; D006632:Histamine / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010567:Pertussis Vaccine / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D010567:Pertussis Vaccine; D006632:Histamine
Vliianie immunomoduliatorov razlichnogo proiskhozhdeniia na gistaminsensibiliziruiushchuiu aktivnost' korpuskuliarnoĭ kokliushnoĭ vaktsiny.