[Antagonistic effect of re du qing on damage of hepatocytic microsomes in rabbits with endotoxin-induced disseminated intravascular coagulation].
In this study, the generalized Shwartzman reaction of rabbit induced by endotoxin of Escherichia Coli was built as DIC models. The experiment showed that the levels of lipid peroxide (LPO) in the hepatocytic microsomes of model group were increased significantly, whereas the cytochrome P-450 (Cyto. P-450) contents and aniline hydroxylase activities were obviously decreased. In the Re Du Qing (RDQ) group and dexamethasone group the decrease of LPO in hepatocytic microsomes as well as the reduction of Cyto. P-450 contents and aniline hydroxylase activities were alleviated. Furthermore, the correlation analysis indicated a significant negative correlation between levels of LPO in microsomes and the Cyto. P-450 contents as well as aniline hydroxylase activities. This study indicates the LPO may play an important role in the damage of hepatocytic microsomes and RDQ could prevent hepatocytic microsomes from injury of rabbits with endotoxin-induced DIC.
Tu
S H
SH
Institute of Integration of TCM and WM, Tongji Medical Usiversity, Wuhan.
Li
M Z
MZ
Ye
W Y
WY
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D004731:Endotoxins; D004926:Escherichia coli; D005260:Female; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000473:pathology; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism / Q000473:pathology*; D011817:Rabbits
D004365:Drugs, Chinese Herbal; D004731:Endotoxins; D008054:Lipid Peroxides; D003577:Cytochrome P-450 Enzyme System