Fate of a single dose of the 14C-labelled mycotoxin, fumonisin B1, in rats.
The fate of the mycotoxin, fumonisin B1, (FB1) dosed to rats by i.p. injection and by gavage was traced using 14C-labelled FB1. Twenty-four hours after i.p. injection, 66% of the radioactivity was recovered in faeces, 32% in urine, 1% in liver and trace amounts (less than 1%) in kidney and red blood cells. When dosed by gavage, all (101%) radioactivity was recovered in faeces and trace amounts were found in urine, liver, kidney and red blood cells. The bulk of the radioactivity recovered was unmetabolized FB1.
Shephard
G S
GS
Programme on Mycotoxins and Experimental Carcinogenesis, South African Medical Research Council, Tygerberg.
Thiel
P G
PG
Sydenham
E W
EW
Alberts
J F
JF
Gelderblom
W C
WC
D000818:Animals; D002250:Carbon Radioisotopes; D002274:Carcinogens, Environmental / Q000493:pharmacokinetics*; D037341:Fumonisins; D008297:Male; D009183:Mycotoxins / Q000493:pharmacokinetics*; D051381:Rats; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D002274:Carcinogens, Environmental; D037341:Fumonisins; D009183:Mycotoxins; C056933:fumonisin B1