title: Magnetoencephalography of focal cerebral ischemia in rats.
abstract: OBJECTIVE
  The purpose of this study was to use magnetoencephalography to record magnetic field changes in the brain during middle cerebral artery occlusion.
  
  
  METHODS
  A direct-current electrocorticogram (two channels) and a direct-current magnetoencephalogram (seven channels) were simultaneously recorded from five rats subjected to middle cerebral artery occlusion for 1-2 hours.
  
  
  RESULTS
  Direct-current electrocorticographic and direct-current magnetoencephalographic signal deflections were observed after the onset of middle cerebral artery occlusion and occurred repeatedly throughout the ischemic period, with a mean +/- SD time interval of 12 +/- 5 minutes. A one-to-one correspondence of the electrocorticographic and magnetoencephalographic signal deflections was demonstrated.
  
  
  CONCLUSIONS
  Direct-current magnetoencephalography can provide a new noninvasive technique for studying depolarization and/or spreading depression in focal cerebral ischemia.
authors.affiliation: Department of Neurology, Henry Ford Hospital, Detroit, Mich. 48202.
authors.forename: Q
authors.initials: Q
authors.lastname: Chen
authors.forename: M
authors.initials: M
authors.lastname: Chopp
authors.forename: H
authors.initials: H
authors.lastname: Chen
authors.forename: N
authors.initials: N
authors.lastname: Tepley
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000175:diagnosis*; D002540:Cerebral Cortex / Q000503:physiopathology; D004569:Electroencephalography; D015225:Magnetoencephalography; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains