title: Vitamin B-6 status of breast-fed neonates: influence of pyridoxine supplementation on mothers and neonates.
abstract: Vitamin B-6 concentrations in human milk are known to respond rapidly to changes in maternal vitamin B-6 intake. In this study, mothers were supplemented during the first 28 d of lactation with 2 or 27 mg pyridoxine (PN)-HCl/d and a subgroup of breast-fed infants of the 2-mg/d-supplemented mothers were supplemented with 0.4 mg PN-HCl/d. Vitamin B-6 intakes of breast-fed infants reflected the amount of their mother's supplement; intakes were highest for the vitamin-supplemented infants. Vitamin B-6 intake of mothers was a strong indicator of infant vitamin B-6 status. Vitamin intake of infants correlated significantly with five measures of vitamin B-6 status. Plasma pyridoxal-5'-phosphate (PLP) concentrations and birth weight were the strongest predictors of infant growth that were examined. Alkaline phosphatase activity in the mother's milk and infant plasma reflected pyridoxal-PLP ratios in these fluids, suggesting that the enzyme acts in regulating circulating vitamer concentrations.
authors.affiliation: Department of Foods and Nutrition, Purdue University, West Lafayette, IN.
authors.forename: S A
authors.initials: SA
authors.lastname: Kang-Yoon
authors.forename: A
authors.initials: A
authors.lastname: Kirksey
authors.forename: G
authors.initials: G
authors.lastname: Giacoia
authors.forename: K
authors.initials: K
authors.lastname: West
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000032:analysis; D001724:Birth Weight; D001942:Breast Feeding; D004912:Erythrocytes / Q000737:chemistry; D005260:Female; D006128:Growth; D006801:Humans; D007231:Infant, Newborn; D007774:Lactation / Q000187:drug effects; D008895:Milk, Human / Q000737:chemistry*; D009752:Nutritional Status; D011736:Pyridoxine / Q000008:administration & dosage* / Q000032:analysis / Q000097:blood*
chemical_list: D000469:Alkaline Phosphatase; D011736:Pyridoxine