title: Angiographic findings in the coronary arteries after thrombolysis in acute myocardial infarction.
abstract: The angiographic appearance of the coronary arteries was examined in 308 patients with acute myocardial infarction (AMI) who received high-dose intravenous thrombolytic therapy. Coronary angiography was performed on day 7 after admission to the hospital. Patients had an average of 2.4 discrete arterial narrowings or obstructions. The narrowings were proximal and related to bifurcations. Four fifths of the culprit arteries were patient; 104 (34%) had a ruptured plaque, 22 (7%) had an ulcerated plaque, and in 190 (62%) the lesions were eccentric. Patients differed from a comparable, previously studied, control series of 302 patients with chronic stable angina pectoris who had more extensive disease. They had 5.7 narrowings/patient, also located proximally and at bifurcations, but more widely distributed in the coronary tree. Patients with AMI who are suitable for thrombolysis have a unique coronary angiographic picture. The data confirm that AMI is caused by sudden rupture of a localized atheromatous plaque that initiates an obstructive thrombotic cascade.
authors.affiliation: Cardiac Department, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Gotsman
authors.forename: S
authors.initials: S
authors.lastname: Rosenheck
authors.forename: H
authors.initials: H
authors.lastname: Nassar
authors.forename: S
authors.initials: S
authors.lastname: Welber
authors.forename: D
authors.initials: D
authors.lastname: Sapoznikov
authors.forename: M
authors.initials: M
authors.lastname: Mosseri
authors.forename: A
authors.initials: A
authors.lastname: Weiss
authors.forename: C
authors.initials: C
authors.lastname: Lotan
authors.forename: Y
authors.initials: Y
authors.lastname: Rozenman
mesh_terms: D000787:Angina Pectoris / Q000000981:diagnostic imaging; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000209:etiology; D013300:Streptokinase / Q000627:therapeutic use*; D015912:Thrombolytic Therapy; D013997:Time Factors
chemical_list: D013300:Streptokinase