title: The adsorption of isopropanol and acetone by activated charcoal.
abstract: This study was performed to determine the adsorption of isopropanol and acetone by activated charcoal over a range of charcoal:solvent ratios. The charcoal binding of isopropanol was studied in both hydrochloric acid and water solutions, while acetone was analyzed in water. Gram ratios of charcoal to solvent ranged from 1:1 to 20:1. After the addition of charcoal the solution was agitated and centrifuged. The supernatant was then analyzed by gas chromatography. Each increment in charcoal dose increased the percent adsorption of both isopropanol and acetone. At the 20:1 ratio 87-92% of the solvent was bound by activated charcoal. In vivo study is needed to determine if activated charcoal therapy can shorten the half-life of isopropanol and acetone and decrease the duration of supportive care needed following ingestions of these solvents.
authors.affiliation: Central Pennsylvania Poison Center, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
authors.forename: K K
authors.initials: KK
authors.lastname: Burkhart
authors.forename: M A
authors.initials: MA
authors.lastname: Martinez
mesh_terms: D000433:1-Propanol / Q000737:chemistry*; D000096:Acetone / Q000737:chemistry*; D000327:Adsorption; D002606:Charcoal / Q000737:chemistry*; D002849:Chromatography, Gas; D007700:Kinetics
chemical_list: D000096:Acetone; D002606:Charcoal; D000433:1-Propanol