Transcription factors: positive and negative regulators of cell growth and disease.
Recent advances in our understanding of transcription factors that regulate RNA polymerase II transcribed genes are described. This review considers the role of alternate protein-protein interactions to yield positive or negative regulation, the consequences of deregulated factor activity on cell function and approaches to establish factor-binding specificities.
Morimoto
R I
RI
Department of Biochemistry, Molecular and Cell Biology, Northwestern University, Evanston, Illinois.
D000818:Animals; D001665:Binding Sites; D002451:Cell Compartmentation; D002455:Cell Division / Q000235:genetics* / Q000502:physiology; D004247:DNA / Q000378:metabolism; D004194:Disease / Q000209:etiology; D014176:Protein Biosynthesis; D012326:RNA Splicing; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*
D014157:Transcription Factors; D004247:DNA