Plasma L-[18F]6-fluorodopa input function: a simplified method.
This article describes a simplified method for the determination of the L-[18F]6-fluorodopa (FDOPA) fraction time course that takes advantage of the strong correlation between the radioactivity ratio (metabolites/FDOPA) and time. Serial arterial blood samples are collected for assay of plasma total radioactivities following an intravenous injection of FDOPA into carbidopapretreated subjects. In addition, a single plasma sample, collected late in the study and analyzed for FDOPA fraction, is sufficient to determine accurately the time course of the FDOPA concentration in plasma. The validated straight-line method greatly simplifies blood analysis for routine positron emission tomography FDOPA studies.
Chan
G L
GL
UBC/TRIUMF, Program on Positron Emission Tomography, University of British Columbia, Vancouver, Canada.
Morrison
K S
KS
Holden
J E
JE
Ruth
T J
TJ
D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives* / Q000097:blood; D005462:Fluorine Radioisotopes; D006801:Humans; D012044:Regression Analysis; D013997:Time Factors; D014055:Tomography, Emission-Computed / Q000379:methods*
D005462:Fluorine Radioisotopes; C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine