title: Repeat sequences in the gene encoding the human D4 dopamine receptor.
abstract: The gene encoding the human D4 dopamine receptor has evolved by gaining at least five internal repeats which are located within exons 3 and 4, and in the intervening intron 3 sequence. The amino acid sequence in the cytoplasmic loop of the receptor, involved in G protein coupling, has been altered by these gene changes.
authors.affiliation: Addiction Research Foundation, Toronto, Ontario, Canada.
authors.forename: B F
authors.initials: BF
authors.lastname: O'Dowd
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D005091:Exons / Q000235:genetics; D006801:Humans; D007438:Introns / Q000235:genetics; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011954:Receptors, Dopamine / Q000737:chemistry / Q000235:genetics*; D017448:Receptors, Dopamine D2; D050638:Receptors, Dopamine D4; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
chemical_list: C493599:DRD4 protein, human; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D050638:Receptors, Dopamine D4