Complete disappearance of metastatic abdominal tumors from gastric cancer after treatment with irsogladine maleate.
A 60-year-old woman with gastric cancer had undergone partial gastrectomy in September 1989. Pathological examination revealed a poorly differentiated adenocarcinoma of pT3pN3pM0 (not resected for cure), stage IV. Postoperative adjuvant therapy comprised 1-(tetrahydro-2-furanyl)-5-fluorouracil plus uracil and OK-432. On 11 August 1990, two forefinger-tip-sized tumors were palpated beneath the operation scar. They increase in size, the superior tumor reaching 4x3 cm, the inferior tumor 5x3 cm on 5 September. Then, on 17 September, the inferior tumor was resected but the superior tumor remained; the histological type was poorly differentiated adenocarcinoma. After the operation, from 20 September, she was given 4 mg irsogladine maleate orally every day. On 8 October, there was no increase in the size of the superior tumor. By 29 October, the superior tumor had disappeared and no further tumor appeared thereafter; the patient showed no sign of relapse.
Hosokawa
T
T
Department of Surgery, Tokyo Women's Medical College, Daini Hospital, Japan.
Otani
Y
Y
Ogawa
K
K
Kajiwara
T
T
D000008:Abdominal Neoplasms / Q000188:drug therapy* / Q000556:secondary* / Q000601:surgery; D000230:Adenocarcinoma / Q000188:drug therapy / Q000556:secondary / Q000601:surgery; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D012074:Remission Induction / Q000379:methods; D013274:Stomach Neoplasms / Q000473:pathology*; D014227:Triazines / Q000008:administration & dosage / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D014227:Triazines; D016685:Mitomycin; C041836:irsogladine; D005472:Fluorouracil