title: Single-dose oral omeprazole for reduction of gastric residual acidity in adults for outpatient surgery.
abstract: Omeprazole is a substituted benzimidazole that causes dose-dependent intracellular inhibition of gastric acid secretion in humans. This double-blind study examined the effect of omeprazole in decreasing gastric acidity and gastric residual volume in outpatient adults. Unpremedicated outpatients, ASA I-III, 18 years or older (n = 17), were randomly assigned to receive omeprazole 80 mg, or placebo by mouth the night before scheduled elective outpatient surgery. The patients were fasted for 8 h prior to surgery. After the patient was anesthetized, an orogastric tube was inserted with proper placement verified by auscultation for gastric sounds. Gastric residual contents were withdrawn into a Luken's trap, and pH was then determined and gastric volume indexed to weight (ml.kg-1). Data were analyzed by a t-test, with P less than 0.05 considered statistically significant. Patient characteristics of both groups were similar. There was a statistically significant difference between the two groups for pH (P = 0.02), but not between the two groups for gastric volume indexed to weight (P = 0.07).
authors.affiliation: Department of Anesthesiology, Tulane University School of Medicine, New Orleans, Louisiana.
authors.forename: D A
authors.initials: DA
authors.lastname: Haskins
authors.forename: J S
authors.initials: JS
authors.lastname: Jahr
authors.forename: M
authors.initials: M
authors.lastname: Texidor
authors.forename: U
authors.initials: U
authors.lastname: Ramadhyani
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000556:Ambulatory Surgical Procedures; D003864:Depression, Chemical; D004311:Double-Blind Method; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D009853:Omeprazole / Q000008:administration & dosage*
chemical_list: D009853:Omeprazole