title: Hypersensitivity reactions to cisplatin and carboplatin--a report on six cases.
abstract: Anaphylactic reactions to platinum compounds are well recognised, but uncommon. These vary from true type I reactions to direct histamine release due to nonimmunological mechanisms. We present 6 cases to illustrate this--5 due to cisplatin and a report of this occurring with carboplatin--with a near fatal outcome in 3 of the cases.
authors.affiliation: Department of Medicine, Royal Marsden Hospital, London, U.K.
authors.forename: M P
authors.initials: MP
authors.lastname: Saunders
authors.forename: C P
authors.initials: CP
authors.lastname: Denton
authors.forename: M E
authors.initials: ME
authors.lastname: O'Brien
authors.forename: P
authors.initials: P
authors.lastname: Blake
authors.forename: M
authors.initials: M
authors.lastname: Gore
authors.forename: E
authors.initials: E
authors.lastname: Wiltshaw
mesh_terms: D000328:Adult; D000368:Aged; D000707:Anaphylaxis / Q000139:chemically induced*; D016190:Carboplatin / Q000009:adverse effects*; D002945:Cisplatin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D016190:Carboplatin; D002945:Cisplatin