Experimental Albizia versicolor poisoning in sheep and its successful treatment with pyridoxine hydrochloride.
Five sheep developed severe nervous signs after being drenched with Albizia versicolor pod-material. Four of these sheep were treated with pyridoxine hydrochloride (a vitamin B6) when the symptoms of toxicity became life-threatening. All the treated sheep recovered dramatically and completely after treatment while the untreated one died 2 h after receiving pod-material. A therapeutic dose of 20-25 mg pyridoxine hydrochloride/kg body mass given twice with an 8 h interval is the recommended treatment regimen. The route of administration will depend on the severity of symptoms. Chemical pathology and post-mortem findings are discussed.
Gummow
B
B
Department of Infectious Diseases, Faculty of Veterinary Science, Onderstepoort.
Bastianello
S S
SS
Labuschagne
L
L
Erasmus
G L
GL
D000818:Animals; D005260:Female; D010865:Pilot Projects; D010939:Plant Poisoning / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D010947:Plants, Toxic; D011736:Pyridoxine / Q000627:therapeutic use*; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology
D011736:Pyridoxine