[Mannitol solution (M-400) vs. mannitol solution combined with allopurinol in the prevention of post-transfusion acute renal failure].
Evaluation on the incidence of Acute Renal Failure (ARF) from a total of 41 corpse renal graft receptors, 20 of which received perfusion with mannitol solution at 400 mOsm/kg (Group 1) and 21 the same mannitol solution plus allopurinol (Group 2). No significant differences were present between both groups when they were analyzed for ARF incidence (15% vs 23.8%); overall incidence was 19.5%. 24-hour initial diuresis was shown to be an excellent predictor for long-term graft functionality. We can conclude that the addition of mannitol to the perfusion solution contributes decisively to reduce post-transplantation ARF, while addition of allopurinol does not have further beneficial effects.
López-Costea
M A
MA
Servicio de Urología, Hospital Príncipes de España, L'Hospitalet, Barcelona.
Griñó
J M
JM
Serón
D
D
Domingo
R
R
Caballero
J M
JM
Riera
L
L
Franco-Miranda
E
E
Serrallach
N
N
D058186:Acute Kidney Injury / Q000517:prevention & control*; D000493:Allopurinol / Q000008:administration & dosage*; D002102:Cadaver; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D006084:Graft Rejection / Q000187:drug effects; D006801:Humans; D016030:Kidney Transplantation; D008353:Mannitol / Q000008:administration & dosage*
D008353:Mannitol; D000493:Allopurinol
Solución de manitol (M-400) versus solución de manitol y alopurinol en la prevención del fracaso renal agudo post-TR.