title: Pharmacokinetic profiles of ciprofloxacin after single intravenous and oral doses.
abstract: Ciprofloxacin was administered to 12 healthy male volunteers at doses of 300 and 400 mg intravenously (i.v.) and 500 and 750 mg orally in a randomized, double-blind, single-dose, four-period crossover study. On each treatment day, each subject received both oral and i.v. formulations, one of which was a placebo. Blood and urine samples were obtained through 24 h postdose. By each dosing route, the pharmacokinetic profiles were dose proportional. The 400-mg i.v. dose was equivalent to the 500-mg oral dose with respect to the area under the concentration-time curve and was equivalent to the 750-mg oral dose with respect to the maximum concentration of ciprofloxacin in serum. The oral bioavailability was 78.0%. The steady-state volume of distribution averaged 178 liters, and the terminal half-life in serum after i.v. dosing was approximately 4.3 h. Renal clearance accounted for approximately 60% of total body clearance. No significant adverse events were associated with either route of administration.
authors.affiliation: Department of Clinical Pharmacology, Miles, Inc., West Haven, Connecticut 06516.
authors.forename: J T
authors.initials: JT
authors.lastname: Lettieri
authors.forename: M C
authors.initials: MC
authors.lastname: Rogge
authors.forename: L
authors.initials: L
authors.lastname: Kaiser
authors.forename: R M
authors.initials: RM
authors.lastname: Echols
authors.forename: A H
authors.initials: AH
authors.lastname: Heller
mesh_terms: D000284:Administration, Oral; D001682:Biological Availability; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004311:Double-Blind Method; D006801:Humans; D007275:Injections, Intravenous; D008297:Male
chemical_list: D002939:Ciprofloxacin