Cell-mediated immunity in cervical intraepithelial neoplasia.
Various immune parameters, i.e., peripheral T and B cell distribution, T cell subpopulation, interleukin 2 (IL-2) activity and in vitro lymphocyte responses to phytohemagglutinin (PHA) and concanavalin A (Con A), were investigated in 24 pretreated patients with cervical intraepithelial neoplasia (CIN) and in 35 normal controls. Of the measured parameters, lymphocyte response to PHA was significantly lower in the CIN than control group (P less than 0.05). The values of all other measured parameters were similar in both groups.
Park
T K
TK
Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea.
Kim
S N
SN
Choi
D H
DH
Lee
C H
CH
D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D002278:Carcinoma in Situ / Q000276:immunology*; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007376:Interleukin-2 / Q000096:biosynthesis; D007958:Leukocyte Count; D010835:Phytohemagglutinins; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000276:immunology*
D007376:Interleukin-2; D010835:Phytohemagglutinins; D003208:Concanavalin A