Potential organ or tumor imaging agents. 32. A triglyceride ester of p-iodophenyl pentadecanoic acid as a potential hepatic imaging agent.
A triglyceride analog, glycerol-2-palmitoyl-1,3-di-15-(p-iodophenyl)pentadecanoate (DPPG) was synthesized and radiolabeled for evaluation as a potential functional liver scintigraphic agent. Uptake of DPPG was compared in normal, diabetic, tumor-bearing and heparin pretreated rats, revealing differences in uptake and clearance of radioactivity, correlating with hepatic lipase activity of these groups. Similar results were observed by gamma-camera scintigraphy. Comparing the uptake of DPPG with that of its fatty acid component, 15-(p-iodophenyl)pentadecanoic acid (IPPA), revealed that the peak uptake of IPPA in the liver was about half that of DPPG. Based upon these findings, DPPG warrants further study as a hepatic radiodiagnostic agent.
Schwendner
S W
SW
Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48109.
Weichert
J P
JP
Longino
M A
MA
Gross
M D
MD
Counsell
R E
RE
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D004285:Dogs; D005069:Evaluation Studies as Topic; D005260:Female; D015902:Gamma Cameras; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes / Q000378:metabolism / Q000493:pharmacokinetics*; D008049:Lipase / Q000378:metabolism; D008074:Lipoproteins / Q000378:metabolism; D008099:Liver / Q000000981:diagnostic imaging* / Q000201:enzymology / Q000378:metabolism; D008954:Models, Biological; D009369:Neoplasms / Q000000981:diagnostic imaging*; D010715:Phosphatidylglycerols / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D014280:Triglycerides / Q000378:metabolism / Q000493:pharmacokinetics*; D014304:Triolein / Q000378:metabolism
D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008074:Lipoproteins; D010715:Phosphatidylglycerols; D014280:Triglycerides; D014304:Triolein; C025391:omega-(4-iodophenyl)pentadecanoic acid; C005859:tripalmitin; D008049:Lipase; C030345:1,2-dipalmitoylphosphatidylglycerol