[The possible nephrotoxicity of a bituminous coal dermatologic agent].
Nephrotoxic effects are discussed as a possible risk of dermatological coal tar preparations. Therefore, we have performed a renal tolerance study with a modern coal tar preparation for the scalp, Berniter. 15 healthy volunteers, randomly subjected to 3 different modes of application, applied the preparation: twice weekly (mode I) or daily (mode II) for a period of 8 weeks. In both modes, application time was 15 min. In mode III, the preparation was used under occlusion for 30 min every second day for a period of 4 weeks. Before, during and after treatment, renal functions and urinary phenol levels were assayed. No pathological change or impairment of renal functions was detected. A relationship between urinary phenol content and the coal tar treatment was not observed, either. We conclude that the coal tar preparation investigated here has no nephrotoxic properties.
Wright
M C
MC
Basotherm GmbH, Biberach, Johann Wolfgang Goethe-Universität Frankfurt a.M.
Kaufhold
A
A
Hevert
F
F
Holzmann
H
H
D000287:Administration, Topical; D000328:Adult; D003033:Coal Tar / Q000506:poisoning*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D019800:Phenol; D010636:Phenols / Q000506:poisoning; D012535:Scalp / Q000187:drug effects*
D010636:Phenols; D019800:Phenol; D003033:Coal Tar
Untersuchungen zur möglichen Nephrotoxizität eines steinkohlenteerhaltigen Dermatikums.