Mersacidin, a new antibiotic from Bacillus. Fermentation, isolation, purification and chemical characterization.
Mersacidin (1) is a new peptide antibiotic containing beta-methyllanthionine. It is classified as a member of the proposed lantibiotic group of antibiotics, and is produced by a species of Bacillus. Mersacidin has a molecular weight of 1,824 (C80H120N20O21S4). The antibiotic is active against Gram-positive organisms including methicillin-resistant Staphylococcus aureus, but has no activity against Gram-negative bacteria or fungi.
Chatterjee
S
S
Microbiology Department, Hoechst India Limited, Mulund, Bombay.
Chatterjee
S
S
Lad
S J
SJ
Phansalkar
M S
MS
Rupp
R H
RH
Ganguli
B N
BN
Fehlhaber
H W
HW
Kogler
H
H
D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D001407:Bacillus / Q000378:metabolism*; D001430:Bacteriocins; D005285:Fermentation; D010452:Peptide Biosynthesis; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D001430:Bacteriocins; D010455:Peptides; C069959:mersacidin