title: Educational computer simulation of malignant hyperthermia.
abstract: An educational graphic simulator was developed to provide an interactive learning environment to practice the diagnosis and treatment of malignant hyperthermia. The program incorporates a set of dynamically interacting models to present the physiologic changes associated with malignant hyperthermia and the simulated patient's response to management. Cardiovascular, respiratory, and temperature changes are presented through a graphic display of the operating room monitors. Mouse-driven input is used to manage the airway, control ventilation, manage cardiovascular and rhythm disturbances, and control fluids, electrolytes, and temperature. Medications, including dantrolene, antidysrhythmics, diuretics, and sodium bicarbonate, can be administered. Four simulated patients with different presentations of malignant hyperthermia are included to illustrate variations in the syndrome. Two of these patients are described in detail.
authors.affiliation: Department of Anesthesiology, University of Washington, Seattle 98195.
authors.forename: H A
authors.initials: HA
authors.lastname: Schwid
authors.forename: D
authors.initials: D
authors.lastname: O'Donnell
mesh_terms: D000328:Adult; D001831:Body Temperature; D003198:Computer Simulation; D003620:Dantrolene / Q000627:therapeutic use; D004501:Education, Medical; D005260:Female; D006221:Halothane / Q000009:adverse effects; D006801:Humans; D008305:Malignant Hyperthermia / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D008954:Models, Biological; D008955:Models, Cardiovascular; D009132:Muscles / Q000503:physiopathology; D009609:Nitrous Oxide / Q000009:adverse effects; D010599:Pharmacokinetics; D010600:Pharmacology; D012119:Respiration; D012985:Software Design; D013390:Succinylcholine / Q000009:adverse effects; D013663:Teaching / Q000379:methods; D014882:Water-Electrolyte Balance
chemical_list: D003620:Dantrolene; D013390:Succinylcholine; D009609:Nitrous Oxide; D006221:Halothane