title: Overexpression of oskar directs ectopic activation of nanos and presumptive pole cell formation in Drosophila embryos.
abstract: In Drosophila, a small group of maternal effect genes, including oskar, defines a shared pathway leading to the provision of two determinants at the posterior pole of the embryo. One determinant is the posterior body patterning morphogen nanos, and the other directs germ cell formation. Overexpression of oskar causes the shared pathway to be hyperactivated, with excess nanos activity present throughout the embryo and a superabundance of posterior pole cells. In addition, presumptive pole cells appear at a novel anterior position. Strikingly, formation of these ectopic pole cells is enhanced in nanos mutants. This observation may reflect competition between nanos and the germ cell determinant for a shared and limiting precursor.
authors.affiliation: Department of Biological Sciences Stanford University, California 94305.
authors.forename: J L
authors.initials: JL
authors.lastname: Smith
authors.forename: J E
authors.initials: JE
authors.lastname: Wilson
authors.forename: P M
authors.initials: PM
authors.lastname: Macdonald
mesh_terms: D000818:Animals; D004330:Drosophila / Q000196:embryology*; D029721:Drosophila Proteins; D005786:Gene Expression Regulation; D007301:Insect Hormones / Q000502:physiology*; D009024:Morphogenesis; D016601:RNA-Binding Proteins
chemical_list: D029721:Drosophila Proteins; D007301:Insect Hormones; D016601:RNA-Binding Proteins; C070574:nos protein, Drosophila