[Thermal properties of chromatin in vivo during interaction with cis[Pt(CuO)2(CuOH)2]].
Thermal properties of chromatin in cell composition of BALB/c mice and whole chromatin at injection of cis-Pt(CuO)2(CuOH)2 to experimental animals were studied by high sensitive DSM assigning for investigating complex biological systems. It is established that injection of cis-Pt(CuO)2(CuOH)2 to leukemic mice in vivo changes the thermal characteristics of spleen cells, so that they look like the thermal properties of the healthy mice spleen cells. It was supposed that small doses of Pt(CuO)2(CuOH)2 in the case of leukemia show anticarcinogenic properties and the overdoses promote malignization; in the norm at any concentration of the injected salt cancerogenic properties are exhibited.
Monaselidze
D R
DR
Kalandadze
Ia L
IaL
Chapchalashvili
Z I
ZI
Madzhagaladze
G V
GV
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002152:Calorimetry, Differential Scanning; D002843:Chromatin / Q000187:drug effects* / Q000378:metabolism; D003300:Copper / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006358:Hot Temperature; D007942:Leukemia, Experimental / Q000188:drug therapy / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D010984:Platinum / Q000494:pharmacology*; D017671:Platinum Compounds; D013154:Spleen / Q000187:drug effects / Q000378:metabolism
D000970:Antineoplastic Agents; D002843:Chromatin; D017671:Platinum Compounds; C076595:Pt(II)(CuO)2(CuOH)2; D010984:Platinum; D003300:Copper
Teplovye svoĭstva khromatina in vivo pri vzaimodeĭstvii s tsi-[Pt(CuO)2(CuOH)2]