Oxygen radicals as key mediators in neurological disease: fact or fiction?
A free radical is any species capable of independent existence that contains one or more unpaired electrons. Free radicals and other reactive oxygen species are frequently proposed to be involved in the pathology of several neurological disorders. Criteria for establishing such involvement are presented. Development of new methods for measuring oxidative damage should enable elucidation of the precise role of reactive oxygen species in neurological disorders.
Halliwell
B
B
Division of Pulmonary-Critical Care Medicine, University of California Davis Medical Center, Sacramento 95817.
D000818:Animals; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D009422:Nervous System Diseases / Q000378:metabolism*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*
D005609:Free Radicals; D010100:Oxygen