Synthesis of active metabolite(s) from 1 alpha-hydroxyvitamin D3 by human monocytic leukemia cells.
Synthesis of the biologically active metabolite(s) from 1 alpha-hydroxyvitamin D3 (1 alpha(OH)D3) was examined in various types of human leukemia cell lines. Untreated monocytoid leukemia cells (U937 and HEL/S) metabolized 1 alpha (OH)D3 to the active metabolite(s), possibly 1 alpha, 24- and/or 1 alpha, 25-dihydroxyvitamin D3, and these cells were efficiently induced to differentiate by treatment with 1 alpha (OH)D3. However, the other types of leukemia cells did not efficiently metabolize it and were not induced to differentiate by 1 alpha (OH)D3. The possible therapeutic advantage of 1 alpha (OH)D3 in the treatment of monocytic leukemia is discussed.
Okabe-Kado
J
J
Department of Chemotherapy, Saitama Cancer Center Research Institute, Japan.
Honma
Y
Y
Kasukabe
T
T
Hozumi
M
M
D006801:Humans; D006887:Hydroxycholecalciferols / Q000096:biosynthesis / Q000378:metabolism*; D007700:Kinetics; D007948:Leukemia, Monocytic, Acute / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D006887:Hydroxycholecalciferols; C008088:alfacalcidol