[A biochemical study of an animal model with defective muscle glycolysis, induced by iodoacetate administration].
A rat model produced by intraaortic injection of sodium iodoacetate was analyzed biochemically. Hind leg muscles obtained from iodoacetate-injected site showed a selective inhibition of the glyceraldehyde-3-phosphate dehydrogenase (G3PD) activity less than 10% of control mean. No loss of mitochondrial enzyme activity was observed. Electrical stimulation at the sciatic nerve revealed muscle contractures and this muscle showed a mild degeneration in histochemically. This study indicates that this model will be useful to study the pathophysiology of human muscle glycogen storage diseases.
Furukawa
N
N
Department of Pediatrics, Hamamatsu University School of Medicine, Shizuoka.
Sugie
H
H
Tsurui
S
S
Ito
M
M
Igarashi
Y
Y
D000818:Animals; D004195:Disease Models, Animal; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000378:metabolism*; D006008:Glycogen Storage Disease / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D007461:Iodoacetates; D019807:Iodoacetic Acid; D009132:Muscles / Q000201:enzymology / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains
D007461:Iodoacetates; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D019807:Iodoacetic Acid