title: [Hutchinson-Gilford syndrome].
abstract: A case report on a 6-year-old boy suffering from the extremely rare Hutchinson-Gilford syndrome (progeria) is presented. The results of histopathological and immunohistological examination of the scar-like skin lesions are reported. Subcutaneous amorphous nodules were eosinophilic, PAS- und elastica-negative und remained unstained with antibodies against collagen type IV, vimentin, and collagenase. The dense perivascular infiltration consisted of CD4+, CD8-, alpha-1-antichymotrypsin-, MAC 387-, and some vimentin-positive cells. Perinodular blood vessels were more abundant and had a thickened wall. Collagen bundles were swollen. The epidermis appeared atrophic with focal basal cell degeneration.
authors.affiliation: Klinik und Poliklinik für Hautkrankheiten, Friedrich-Schiller-Universität, Jena.
authors.forename: U
authors.initials: U
authors.lastname: Wollina
authors.forename: A
authors.initials: A
authors.lastname: Reuter
authors.forename: H
authors.initials: H
authors.lastname: Schaarschmidt
authors.forename: E
authors.initials: E
authors.lastname: Müller
authors.forename: B
authors.initials: B
authors.lastname: Maak
authors.forename: U
authors.initials: U
authors.lastname: Schmidt
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D002648:Child; D003094:Collagen / Q000378:metabolism; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D011371:Progeria / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D012867:Skin / Q000473:pathology
chemical_list: D003094:Collagen
vernacular_title: Hutchinson-Gilford-Syndrom.