[Multifactor study of combined effects of an antibiotic and polysaccharide in experimental infection].
Multifactorial analysis was applied to the study of the combined effect of doxycycline and a polysaccharide of microbial origin in experimental plague infection. A marked synergistic action of the antibiotic and polysaccharide used in subtherapeutic doses in treatment of the infection was observed. By the results of the experiments polynomial statistic models of the 2nd order were designed and nomographs or equal level lines were plotted. The models and nomographs described the animal survival rate and lifespan within a wide range of the control parameters. The dose/time regimens for the use of the polysaccharide combination with doxycycline were optimized on the basis of the multifactorial analysis.
Nikitin
A V
AV
Makarovskaia
L N
LN
Fomina
I P
IP
Ivanitskaia
L P
LP
Popova
G O
GO
Vinidchenko
N N
NN
Korganov
Ia N
IaN
Gorin
S E
SE
D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004318:Doxycycline / Q000008:administration & dosage*; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D051379:Mice; D010930:Plague / Q000188:drug therapy* / Q000401:mortality / Q000517:prevention & control; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage*; D012240:Rhodococcus
D011135:Polysaccharides, Bacterial; D004318:Doxycycline
Izuchenie v mnogofaktornom éksperimente sochetannogo deĭstviia antibiotika i polisakharida pri éksperimental'noĭnfektsii.