Macrophage inflammatory proteins MIP-1 and MIP-2 are involved in T cell-mediated neutrophil recruitment.
Mice intraperitoneally (i.p.) infected with Mycobacterium bovis bacille Calmette-Guérin (BCG) respond to an i.p. challenge with mycobacterial antigen with an acute and extensive accumulation of neutrophils. This influx was not mimicked by the inoculation of recombinant interferon-gamma (IFN-gamma) or tumor necrosis factor alpha (TNF-alpha). The antigen-induced recruitment of neutrophils was not affected by coinoculation of anti-IFN-gamma antibodies, was enhanced by anti-TNF-alpha antisera, and was significantly reduced by antisera against macrophage inflammatory proteins MIP-1 and MIP-2. The latter two sera had no additive effects. We hypothesize that mycobacteria-specific T cells are triggered by antigen to secrete MIP-1 and MIP-2, which directly mediate, at least partly, the influx of neutrophils that takes place in this model.
Appelberg
R
R
Centro de Citologia Experimental (Instituto Nacional de Investigação Científica), University of Porto, Portugal.
D000818:Animals; D054407:Chemokine CCL4; D054426:Chemokine CXCL2; D016207:Cytokines / Q000276:immunology*; D005260:Female; D007371:Interferon-gamma / Q000276:immunology*; D019402:Macrophage Inflammatory Proteins; D051379:Mice; D008810:Mice, Inbred C57BL; D015846:Monokines / Q000276:immunology*; D009162:Mycobacterium avium / Q000276:immunology*; D009163:Mycobacterium bovis / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology* / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*
D054407:Chemokine CCL4; D054426:Chemokine CXCL2; D016207:Cytokines; D019402:Macrophage Inflammatory Proteins; D015846:Monokines; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma