[Phenotypic and genotypic analysis of acute leukemia--current status of lineage specific classification].
More detailed identification and understanding of the heterogeneity of leukemias using a broad panel of markers seems to be essential for the successful design of more sophisticated and effective treatments. Based on the FAB system, immunological phenotypes using a panel of monoclonal antibodies, and rearrangements of immunoglobulin and T-cell receptor genes, acute leukemia can be divided into six subtypes such as B-lineage, T-lineage, AML, NK-lineage, AUL and mixed lineage leukemia. The definition of B-lineage and T-lineage cells, a new classification for mixed lineage leukemia, incidence of dual rearrangements and their clinical significance are discussed.
Kawa
K
K
Osaka Medical Center and Research Institute for Maternal and Child Health.
Hara
J
J
D000208:Acute Disease; D015703:Antigens, CD / Q000032:analysis; D015329:Gene Rearrangement, T-Lymphocyte; D005803:Genes, Immunoglobulin; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D007938:Leukemia / Q000145:classification / Q000175:diagnosis / Q000235:genetics*; D010641:Phenotype
D015703:Antigens, CD; D005819:Genetic Markers