Factors affecting acetohexamide reductase activities in microsomes and cytosol from the kidney of male rats: age and castration.
Acetohexamide reductase activity in microsomes from the kidney of male rats increased markedly at puberty to approach the maximum level at 8 weeks of age; it was not detected until 4 weeks of age. Furthermore, castration suppressed effectively the activity in kidney microsomes at 8 weeks of age. These findings clearly indicate that the activity in kidney microsomes can be regulated by androgens. On the other hand, in cytosol from the kidney of male rats, a higher acetohexamide reductase activity was observed at all weeks of age tested. Castration had no significant effect on the activity in kidney cytosol.
Imamura
Y
Y
Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Iwamoto
K
K
Higuchi
T
T
Otagiri
M
M
D000375:Aging / Q000378:metabolism; D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D000728:Androgens / Q000378:metabolism; D000818:Animals; D003600:Cytosol / Q000201:enzymology; D007668:Kidney / Q000201:enzymology*; D008297:Male; D008861:Microsomes / Q000201:enzymology; D009919:Orchiectomy; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000502:physiology
D000728:Androgens; D000429:Alcohol Oxidoreductases; C064152:acetohexamide reductase