Characterization of spontaneous and ethanol-induced gastric damage in cirrhotic rats.
Cirrhosis was induced in Sprague-Dawley rats via ligation of the common bile duct. Changes in gastric blood flow and mucosal architecture were examined. Using an ex vivo gastric chamber preparation, the susceptibility of the cirrhotic gastric mucosa to injury by 20% ethanol was also examined. The gastric mucosa of cirrhotic animals was abnormal, even before ethanol administration. The macroscopically visible damage in these animals ranged from superficial hyperemia to epithelial sloughing. These gastric lesions were similar in appearance to the gastropathy described in cirrhotic patients, including "cherry-red spots" and areas of generalized erythema. Cirrhotic rats had a lower resting gastric transmucosal potential difference than control rats, and their gastric mucosa was also significantly more susceptible to damage by topical ethanol application. Ethanol administration caused a significant increase in gastric blood flow in control rats, whereas it significantly decreased gastric blood flow in cirrhotic rats. This lack of a reactive hyperemic response in cirrhotic rats may be responsible for the increased susceptibility of the gastric mucosa to ethanol-induced damage.
Beck
P L
PL
Gastrointestinal Research Group, University of Calgary, Alberta, Canada.
Lee
S S
SS
McKnight
G W
GW
Wallace
J L
JL
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D008026:Ligation; D008099:Liver / Q000473:pathology; D008106:Liver Cirrhosis, Experimental / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D013154:Spleen / Q000473:pathology
D000431:Ethanol