title: Analysis of meconium for cocaine in neonates.
abstract: A solid-phase extraction method was developed for the extraction of first-day meconium samples from premature infants of cocaine-dependent mothers. Extracts were analysed by high-performance liquid chromatography and gas chromatography-mass spectrometry for cocaine and its metabolites. Control stools showed no drug. Meconium from cocaine-dependent mothers showed cocaine in the range 0.1-0.78 micrograms/g. Benzoylecgonine, ecgonine and ecognine methyl ester were not present in the samples, which suggests that the metabolism of cocaine in the premature neonate is limited.
authors.affiliation: Department of Pharmacodynamics, University of Illinois, Chicago 60680.
authors.forename: S P
authors.initials: SP
authors.lastname: Browne
authors.forename: I R
authors.initials: IR
authors.lastname: Tebbett
authors.forename: C M
authors.initials: CM
authors.lastname: Moore
authors.forename: A
authors.initials: A
authors.lastname: Dusick
authors.forename: R
authors.initials: R
authors.lastname: Covert
authors.forename: G T
authors.initials: GT
authors.lastname: Yee
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003042:Cocaine / Q000032:analysis* / Q000378:metabolism; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D008470:Meconium / Q000737:chemistry*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
chemical_list: D003042:Cocaine