Morphologic and histochemical characteristics of skeletal muscle after long-term intramuscular electrical stimulation.
The purpose of this investigation was to examine the morphologic and histochemical characteristics of paraspinal muscles in patients with scoliosis after long-term electrical stimulation. Thirty-six children with idiopathic scoliosis, who had been treated with implantable muscle stimulators, had paraspinal muscle biopsies at the time of implantable muscle stimulator removal. Group A patients whose curve did not progress, had 2.9 years of stimulation stopped at skeletal maturity, with a further 1.5 years of nonstimulation before implant removal and biopsy. In group B patients, who had an average of 2.3 years of stimulation, the curve progressed and stimulation was continued until fusion and biopsy. Neither group showed any increase in the frequency of pathologic changes of paraspinal muscles contrasted with values reported in the literature for scoliotic muscle. In group A patients there was an increased proportion of type 1 fibers on the convex side of the curve compared to the concavity. Despite this finding the curves did not require fusion, suggesting that the increased percentage of type 1 fibers was not the cause of the scoliosis. In group B patients there was an even higher type 1 concentration on the convex side contrasted to the convex side of group A patients.
Wright
J
J
Hospital for Sick Children, Toronto, Ontario, Canada.
Herbert
M A
MA
Velazquez
R
R
Bobechko
W P
WP
D000293:Adolescent; D001706:Biopsy; D002648:Child; D004599:Electric Stimulation Therapy / Q000295:instrumentation; D005260:Female; D006801:Humans; D008297:Male; D009132:Muscles / Q000737:chemistry / Q000473:pathology*; D019736:Prostheses and Implants; D012600:Scoliosis / Q000628:therapy*; D013997:Time Factors