Two karyotypically unrelated clones with the t(5;17) and deletion of 5q in myelodysplastic syndrome.
We report a patient with primary myelodysplastic syndrome (MDS) and two coexisting karyotypically independent clones. Cytogenetic investigation of bone marrow (BM) cells at diagnosis showed, besides the cells with normal karyotype, a clone that manifests an interstitial deletion of the long arm of chromosome 5 and a second one with a t(5;17). The rarity of finding a BM mosaicism in myelodysplasia with 5q- in some cells and different chromosomal abnormalities in others may be considered to support the multistep theory of pathogenesis in MDS.
Novak
A
A
Cytogenetics Laboratory, University Clinical Center, Belgrade, Yugoslavia.
Jankovic
G
G
Rolovic
Z
Z
D000328:Adult; D002872:Chromosome Deletion; D002886:Chromosomes, Human, Pair 17; D002895:Chromosomes, Human, Pair 5; D005260:Female; D006801:Humans; D007621:Karyotyping; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000628:therapy; D014178:Translocation, Genetic / Q000235:genetics*