Modest enhancement of ultrasound-induced mutations in V79 cells in vitro.
V79 cells were insonated (1 MHz, 35 W/cm2, 2 min continuous wave) under temperature conditions previously reported to cause a large increase in acoustic cavitation. The goal was to increase the ease of detecting ultrasound-induced mutations. The data supported the hypothesis that a 3 degrees C gas-equilibration period followed by insonation at 37 degrees C resulted in a detectable increase in resistance to 6-thioguanine with 6 trials per regimen.
Doida
Y
Y
Department of Biology, Shiga University of Medical Science, Japan.
Brayman
A A
AA
Miller
M W
MW
D000818:Animals; D002460:Cell Line; D002470:Cell Survival; D006224:Cricetinae; D004351:Drug Resistance; D009152:Mutagenicity Tests; D009154:Mutation; D013696:Temperature; D013866:Thioguanine; D014465:Ultrasonics
D013866:Thioguanine