title: [Choice of quantitative characteristics of a radiation modifier affinity and the range of its pharmacological action (minireview)].
abstract: On the basis of the literature the necessity of using not only DMF and maximal protective or sensitizing effects, but also the affinity and the range of the pharmacological action of radiation modifiers is argued. The affinity is worth while to expressed as ED50 (the dose that produces a half of the maximal effect), and the range of the pharmacological action as a therapeutic index K = LD50/ED50.
authors.forename: V I
authors.initials: VI
authors.lastname: Kulinskiĭ
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Kovtun
mesh_terms: D000818:Animals; D006801:Humans; D008962:Models, Theoretical; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000633:toxicity; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage / Q000633:toxicity
chemical_list: D011837:Radiation-Protective Agents; D011838:Radiation-Sensitizing Agents
vernacular_title: O vybore kolichestvennykh kharakteristik srodstva radiomodifikatora i shiroty ego farmakologicheskogo deĭstviia (minilitobzor).