Response of laryngeal mechanoreceptors to high-frequency pressure oscillation.
High-frequency pressure oscillations (HFPO) in the upper airway induce arousal, activation of genioglossus muscle, and bronchoconstriction. The present study was designed to determine the response of superior laryngeal nerve afferent fibers to HFPO. In 10 anesthetized dogs spontaneously breathing through a tracheal cannula, the upper airway was converted to a closed system. The activity of thin bundles separated from the peripheral cut end of the superior laryngeal nerve was monitored. Of 104 mechanoreceptors identified, 87 were classified as respiratory modulated and 17 as non-respiratory modulated on the basis of their response to transmural pressure change and muscle activity. The responses of these fibers to HFPO of +/- 2.5 cmH2O at 10, 20, and 30 Hz were determined. Among the respiratory-modulated receptors, 86 of 87 increased their activity in response to HFPO. Of the 17 non-respiratory-modulated receptors, 12 receptors showing a random or tonic activity did not respond to HFPO, whereas the 5 that were silent during control condition responded exclusively to HFPO. Our results show that HFPO of similar frequency but much less magnitude than snoring is capable of activating the vast majority of laryngeal mechanoreceptors. Pressure-sensitive respiratory-modulated endings appear to mediate the arousal and genioglossal response, whereas non-respiratory-modulated receptors responding to HFPO presumably mediate the bronchoconstrictive response.
Zhang
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Department of Pediatrics, University of Texas Medical Branch, Galveston 77550.
Mathew
O P
OP
D000399:Air Pressure; D000818:Animals; D001143:Arousal / Q000502:physiology; D001980:Bronchi / Q000502:physiology; D004285:Dogs; D007830:Larynx / Q000502:physiology*; D008465:Mechanoreceptors / Q000502:physiology*; D009411:Nerve Endings / Q000502:physiology; D009475:Neurons, Afferent / Q000502:physiology; D012119:Respiration / Q000502:physiology; D013961:Thyroid Gland / Q000502:physiology; D014732:Vibration / Q000009:adverse effects*