Agonistic-antagonistic actions of clomiphene citrate on PGF2 alpha fluctuations in ovariectomized rat uterus.
Effects of clomiphene and/or estrogen on uterine prostaglandin (PG) F2 alpha fluctuations in ovariectomized rats were examined. Uterine PGF2 alpha fluctuations were measured at the indicated times after injection of clomiphene and/or estradiol. Antiestrogenic effects of clomiphene on urine weight and PGF2 alpha levels were observed at 6 hr, and its effect on uterine 13,14-dihydro-15-keto-PGF2 alpha forming capacity was observed at 24 hr. At 48 and 72 hr, additive effects were recognized in all parameters. These results indicate that clomiphene possesses agonistic-antagonistic actions on the PGF2 alpha fluctuations in the uterus.
Kogo
H
H
Department of Pharmacology, Tokyo College of Pharmacy, Japan.
Hikikoshi
A
A
D000818:Animals; D002996:Clomiphene / Q000008:administration & dosage / Q000494:pharmacology*; D015237:Dinoprost / Q000031:analogs & derivatives / Q000032:analysis* / Q000096:biosynthesis; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D010052:Ovariectomy; D051381:Rats; D011919:Rats, Inbred Strains; D014599:Uterus / Q000737:chemistry / Q000187:drug effects*
D002996:Clomiphene; C008228:15-keto-13,14-dihydroprostaglandin F2alpha; D004958:Estradiol; D015237:Dinoprost