PI-200 and PI-201, new platelet aggregation inhibitors produced by Streptomyces sp. A7498. Taxonomy, fermentation, isolation, physico-chemical properties, structure determination and biological properties.
Two new platelet aggregation inhibitors, PI-200 and PI-201 were isolated from the fermentation broth of Streptomyces sp. A7498. PI-200 and PI-201 inhibited ADP-induced aggregation of rabbit platelets with an IC50 of 3.8 x 10(-4) M and 7.1 x 10(-4) M, respectively.
Kishimura
Y
Y
Research Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Kawashima
A
A
Kagamizono
T
T
Yamagishi
M
M
Matsumoto
K
K
Kawashima
Y
Y
Hanada
K
K
D000818:Animals; D005285:Fermentation; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010616:Phenanthrenes / Q000302:isolation & purification* / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011817:Rabbits; D013302:Streptomyces / Q000145:classification / Q000378:metabolism
D009281:Naphthalenes; D010616:Phenanthrenes; D010975:Platelet Aggregation Inhibitors; C076085:PI 201; C076084:PI 200