title: Double-tracer SPECT in patients with AIDS encephalopathy: a comparison of 123I-IMP with 99Tcm-HMPAO.
abstract: Single photon emission computed tomography (SPECT) using N-isopropyl-p-(123I)iodoamphetamine (123I-IMP) and 99Tcm-hexamethylpropyleneamine oxime (99Tcm-HMPAO) was performed in 25 patients with different clinical stages of AIDS encephalopathy. The average interval between the two examinations was 7 days. In 15 of the 25 cases (60%) 99Tcm-HMPAO scans were different from 123I-IMP scans. Uptake defects of different extent were observed in 8 of 25 cases (32%), of different extent and different location in 3 of 25 cases (12%) and of identical extent but of different location in 4 of 25 cases (16%). Differences in the uptake patterns of 123I-IMP and 99Tcm-HMPAO with regard to extent and/or location were more commonly shown in patients with early acquired immunodeficiency syndrome (AIDS) encephalopathy (P = 0.0372). In this group, 99Tcm-HMPAO showed uptake defects of greater extent more frequently than did 123I-IMP (P = 0.0156). Our data indicate different brain uptake mechanisms of 123I-IMP and 99Tcm-HMPAO in early and advanced AIDS encephalopathy.
authors.affiliation: Department of Neurology, Innsbruck University Hospital, Austria.
authors.forename: P
authors.initials: P
authors.lastname: Pohl
authors.forename: G
authors.initials: G
authors.lastname: Riccabona
authors.forename: E
authors.initials: E
authors.lastname: Hilty
authors.forename: F
authors.initials: F
authors.lastname: Deisenhammer
authors.forename: H
authors.initials: H
authors.lastname: Rösslér
authors.forename: R
authors.initials: R
authors.lastname: Zangerle
authors.forename: F
authors.initials: F
authors.lastname: Gerstenbrand
mesh_terms: D015526:AIDS Dementia Complex / Q000000981:diagnostic imaging*; D000328:Adult; D000662:Amphetamines / Q000493:pharmacokinetics; D001921:Brain / Q000378:metabolism; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008297:Male; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics; D010091:Oximes / Q000493:pharmacokinetics; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D020367:Iofetamine