Reducing the time needed to conduct conditioned place preference testing.
The objective of the present experiment was to demonstrate whether four days of twice-a-day conditioned place conditioning produces a preference that is equivalent to that produced by using eight days of once-a-day training. Two doses of the amphetamine-like stimulant drug cathinone (0.2 and 1.6 mg/kg) were selected to demonstrate the effectiveness of twice-a-day (morning-vehicle; afternoon-drug pairings) conditioning. The 0.2 mg/kg dose of cathinone failed to affect the expression of place preference, whereas the 1.6 mg/kg dose produced a significant (p less than 0.002) shift in CPP from baseline when compared to previous measurements. These results demonstrate that twice-a-day pairings over four days effectively shorten the total duration of training without changing the development of place preference produced by once-a-day over eight conditioning day schedule.
Calcagnetti
D J
DJ
Department of Pharmacology, Northeastern Ohio Universities College of Medicine, Rootstown 44272-0095.
Schechter
M D
MD
D000470:Alkaloids / Q000494:pharmacology; D000818:Animals; D002755:Choice Behavior / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D011589:Psychology, Experimental / Q000295:instrumentation / Q000379:methods; D011619:Psychotropic Drugs / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000470:Alkaloids; D011619:Psychotropic Drugs; C023665:cathinone