Protection against dendrotoxin-induced clonic seizures in mice by anticonvulsant drugs.
Various anticonvulsant drugs were evaluated for their ability to protect against clonic seizures induced in mice by intraventricular injection of the K+ channel blocking peptide dendrotoxin (DTX). Phenytoin, the phenytoin-like anticonvulsant carbamazepine and the broad spectrum drug valproate were effective in this model, whereas the GABA-enhancers diazepam and tiagabine, the NMDA antagonists (+/-)-CPP and (+)-MK-801, the AMPA antagonist NBQX, the antiabsence drug ethosuximide and the Ca2+ channel antagonist nimodipine were inactive. In contrast to the lack of activity of other NMDA antagonists, phencyclidine and ADCI [(+/-)-aminocarbonyl-10,11-dihydro-5H-dibenzo [a,d]cyclohepten-5,10-imine] were potent antagonists of DTX-induced seizures.
Coleman
M H
MH
Neuronal Excitability Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.
Yamaguchi
S
S
Rogawski
M A
MA
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D004546:Elapid Venoms / Q000037:antagonists & inhibitors*; D004830:Epilepsy, Tonic-Clonic / Q000517:prevention & control*; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D009498:Neurotoxins / Q000037:antagonists & inhibitors*
D000927:Anticonvulsants; D004546:Elapid Venoms; D009498:Neurotoxins; C020273:dendrotoxin