title: A clinicopathological study of 30 melanomas of the vulva.
abstract: Thirty cases of malignant melanomas of the vulva were studied for prognostic factors. Ulceration, tumor thickness, and positive inguinal lymph nodes were the most important prognostic factors. Morphometry did not demonstrate any prognostic meaning. Traditionally a radical vulvectomy and bilateral inguinal lymph node dissection were the therapy of choice, but this treatment modality did not show a better survival than less radical treatment. A low-risk and a high-risk group of patients have been identified for recurrence. The low-risk patient has a nonulcerative tumor, less than 3 mm thick, without clinical evidence of inguinal lymph node metastases, and should be treated by local excision with a 2- to 3-cm margin. The high-risk patient has a tumor which is ulcerative and/or more than 3 mm thick and should also be treated by local excision without elective inguinal node dissection. If clinical suspicion of inguinal lymph node metastases exists, an inguinal node dissection is advocated for better local control of the disease.
authors.affiliation: The Netherlands Cancer Institute, Amsterdam.
authors.forename: E W
authors.initials: EW
authors.lastname: Tasseron
authors.forename: E P
authors.initials: EP
authors.lastname: van der Esch
authors.forename: A A
authors.initials: AA
authors.lastname: Hart
authors.forename: G
authors.initials: G
authors.lastname: Brutel de la Rivière
authors.forename: E J
authors.initials: EJ
authors.lastname: Aartsen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D014456:Ulcer / Q000473:pathology; D014844:Vulva / Q000601:surgery; D014846:Vulvar Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery