title: [Study on the development of biological-active compounds after the model of natural products].
abstract: In reviewing my lifework, I wish to summarize the results of studies on the development of new biological-active compounds. The following subjects are discussed: 1) syntheses and biological activities of benzoxazole derivatives, 2) structure-activity relationships of phyllodulcin, a natural sweetner, and 3,4-dihydroisocoumarins for sweetness, 3) syntheses and structure-activity relationships of spiro[isocoumarin-piperidine] analogs for antiallergic activity, 4) design, structure-activity relationships, and a mechanism of antitumor action of bistropolone derivatives, 5) design, structure-activity relationships of fused tetracyclic quinolines for antitumor activity.
authors.affiliation: Faculty of Pharmaceutical Sciences, Okayama University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yamato
mesh_terms: D000700:Analgesics; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001578:Benzopyrans / Q000138:chemical synthesis / Q000494:pharmacology; D001583:Benzoxazoles / Q000138:chemical synthesis / Q000494:pharmacology; D004273:DNA, Neoplasm / Q000096:biosynthesis; D015195:Drug Design; D006801:Humans; D049934:Isocoumarins; D039821:Monoterpenes; D011804:Quinolines / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013549:Sweetening Agents; D014334:Tropolone / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000700:Analgesics; D000970:Antineoplastic Agents; D001578:Benzopyrans; D001583:Benzoxazoles; D004273:DNA, Neoplasm; D049934:Isocoumarins; D039821:Monoterpenes; D011804:Quinolines; D013549:Sweetening Agents; C036057:agrimonolide; C031896:6-methoxybenzoxazolinone; D014334:Tropolone; C009479:beta-thujaplicin