Correlations of vitamin A and E intakes with the plasma concentrations of carotenoids and tocopherols among American men and women.
The authors investigated the association of diet and other factors with the plasma concentrations of carotenoids, retinol and tocopherols in a sample of 121 men and 186 women participating in two prospective investigations of dietary etiologies of chronic diseases. Lycopene (mean concentration, 0.82 mumol/L in men, 0.76 mumol/L in women), beta-carotene (mean 0.46 mumol/L in men, 0.58 mumol/L in women) and lutein (mean 0.28 mumol/L in men, 0.27 mumol/L in women) were the major circulating carotenoids. Among nonsmokers, dietary carotenoid, as typically calculated in epidemiologic studies, was significantly correlated with plasma beta-carotene (r = 0.34 in men, r = 0.30 in women), alpha-carotene (r = 0.52 in men, r = 0.37 in women) and lutein (r = 0.36 in men, r = 0.19 in women), but not with plasma zeaxanthin (r = 0.11 and r = 0.02) or lycopene (r = 0.13 and r = 0.01) after adjusting for plasma cholesterol and triglycerides, body mass index and energy intake. Total vitamin E intake was positively associated with plasma concentrations of alpha-tocopherol (r = 0.51 in men, r = 0.41 in women) and inversely associated with plasma concentrations of gamma-tocopherol (r = -0.51 in men r = -0.42 in women), but this was primarily due to use of vitamin E supplements. Measurements of specific carotenoids can provide independent information beyond the usual calculation of carotene intake in epidemiologic studies.
Ascherio
A
A
Department of Epidemiology, Harvard School of Public Health, Boston, MA.
Stampfer
M J
MJ
Colditz
G A
GA
Rimm
E B
EB
Litin
L
L
Willett
W C
WC
D002338:Carotenoids / Q000031:analogs & derivatives / Q000097:blood*; D004032:Diet; D005260:Female; D006801:Humans; D014975:Lutein / Q000097:blood; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012016:Reference Values; D014801:Vitamin A / Q000008:administration & dosage*; D014810:Vitamin E / Q000008:administration & dosage* / Q000097:blood*; D024341:Xanthophylls; D065146:Zeaxanthins; D019207:beta Carotene
D024341:Xanthophylls; D065146:Zeaxanthins; D019207:beta Carotene; D014801:Vitamin A; D014810:Vitamin E; D002338:Carotenoids; C041635:alpha-carotene; D014975:Lutein