title: Inhibition of plaque formation and gingivitis in beagle dogs by topical use of a degradable controlled-release system containing chlorhexidine.
abstract: The in vivo efficacy of a newly-developed dental application of a film-forming, chlorhexidine-containing system was examined in beagle dogs. A self-disintegrating film-forming solution was applied three times weekly to the dentitions of 7 out of 13 dogs, which were fed a soft-food diet. Plaque accumulation (Plaque Index) and gingival inflammation (Gingival Index) were recorded at one, two, four, six, and eight weeks. The local delivery of low-dose chlorhexidine to dogs significantly inhibited gingivitis and plaque formation. It is concluded that the dental application of a film-forming system may be a preferable method of periodontal disease prophylaxis, and may enhance supragingival plaque control in areas of isolated periodontal problems associated with obvious local predisposing factors.
authors.affiliation: Department of Periodontology, Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Kozlovsky
authors.forename: A
authors.initials: A
authors.lastname: Sintov
authors.forename: Y
authors.initials: Y
authors.lastname: Zubery
authors.forename: H
authors.initials: H
authors.lastname: Tal
mesh_terms: D000818:Animals; D002710:Chlorhexidine / Q000008:administration & dosage* / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations; D003773:Dental Plaque / Q000517:prevention & control*; D003774:Dental Plaque Index; D004285:Dogs; D005260:Female; D005891:Gingivitis / Q000517:prevention & control*; D008297:Male; D010512:Periodontal Index
chemical_list: D003692:Delayed-Action Preparations; D002710:Chlorhexidine