title: Responses of human gastroepiploic arteries to vasoactive substances: comparison with responses of internal mammary arteries and saphenous veins.
abstract: We examined the responses of human gastroepiploic arteries to histamine, serotonin, and norepinephrine, comparing those of internal mammary arteries and saphenous veins. Fresh specimens of the vessels were obtained intraoperatively from 21 patients. The vessels were suspended in organ chambers to record isometric tensions. With gastroepiploic arteries, histamine induced relaxations in the endothelial rings (85% +/- 7%) but failed to induce any contractions or relaxations in the rings without endothelium. The relaxations were prevented by methylene blue or hemoglobin and the H1-histaminergic receptor antagonist chlorpheniramine. With internal mammary artery rings with endothelium, histamine at a low concentration (10(-8) to 10(-5.5) mol/L) induced relaxations (53% +/- 12%) but evoked contractions at a higher concentration (10(-5) to 10(-4.5) mol/L). With saphenous veins, histamine caused only contractions. Serotonin induced markedly greater contractions in saphenous veins than in either artery. The endothelium inhibited the maximal contraction in response to serotonin in both arteries but not in veins. With the gastroepiploic artery, the responses to norepinephrine and serotonin were similar to those of the internal mammary artery. Histamine induces endothelium-dependent relaxations only, and histaminergic receptors that induce contractions may be absent on vascular smooth muscle cells. These vasoactive properties may contribute to the high patency as a coronary graft.
authors.affiliation: First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ochiai
authors.forename: M
authors.initials: M
authors.lastname: Ohno
authors.forename: J
authors.initials: J
authors.lastname: Taguchi
authors.forename: K
authors.initials: K
authors.lastname: Hara
authors.forename: H
authors.initials: H
authors.lastname: Suma
authors.forename: T
authors.initials: T
authors.lastname: Isshiki
authors.forename: T
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: K
authors.initials: K
authors.lastname: Kurokawa
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D001158:Arteries / Q000187:drug effects; D001026:Coronary Artery Bypass; D004730:Endothelium, Vascular / Q000187:drug effects; D005260:Female; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D008297:Male; D008323:Mammary Arteries / Q000187:drug effects*; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D009852:Omentum / Q000098:blood supply*; D012501:Saphenous Vein / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology; D013270:Stomach / Q000098:blood supply*
chemical_list: D012701:Serotonin; D006632:Histamine; D000109:Acetylcholine; D009638:Norepinephrine