The inhibitory action of ethanol on the gastric mucosa and its interaction with the vagus in rats.
The influence of systemic ethanol and/or the vagus on ionic secretion and on glandular mucosal blood flow (GMBF) was studied in an ex-vivo gastric chamber preparation in rats. Sub-diaphragmatic vagotomy decreased H+ secretion and Na+ outflux from the gastric mucosa. Subcutaneous injection of 50% ethanol significantly potentiated these responses, but not the concentrations of 25% and 100%. The three doses of ethanol did not affect the secretion of both H+ and Na+ in vagus-intact animals. Ethanol, however dose-dependently reduced the GMBF in both vagus-intact and sub-diaphragmatic vagotomised rats, and the effect was greater in the latter-operated animals. It is concluded that vagus nerves greatly influence the secretion of both H+ and Na+ the gastric mucosa but the effect is unrelated to GMBF. Systemic ethanol reduced the secretion of these ions only in vagotomised animals, indicating the vagus could play a role in modulating the action of ethanol in the stomach.
Cho
C H
CH
Department of Pharmacology, Faculty of Medicine, University of Hong Kong.
D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism; D013270:Stomach / Q000098:blood supply; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology*
D000431:Ethanol; D012964:Sodium