Efficacy of therapeutic interventions for silent myocardial ischemia and clinical trial benefit.
This article reviews the efficacy of medical and revascularization therapeutic interventions directed at the reduction or elimination of silent myocardial The review focuses on the use of standard anti-ischemic medications, including nitrates, calcium antagonists, and beta-blockers. In addition, data suggesting therapeutic benefit of antiplatelet agents are discussed. Finally, the results of studies evaluating the efficacy of revascularization with PTCA and coronary artery bypass graft surgery are reviewed.
Gottlieb
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Johns Hopkins University School of Medicine, Baltimore, Maryland.
D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D015716:Electrocardiography, Ambulatory; D006801:Humans; D016896:Treatment Outcome