title: In vitro cytotoxicity of diorganotin (IV) trimethoxy-benzoates against sixty human NCl tumor cell lines.
abstract: Diethyl- and di-n-butyltin (IV) trimethoxybenzoates were tested in vitro at the National Cancer Institute, Bethesda, Maryland, USA, for cytotoxic activity against a panel of 60 human cell lines. The di-n-butylin compounds are more active in vitro against human tumor cell lines than their diethyltin analogs.
authors.affiliation: Free University of Brussels (V.U.B.), Department of General and Organic Chemistry, Faculty of Engineering, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Gielen
authors.forename: R
authors.initials: R
authors.lastname: Willem
mesh_terms: D004354:Drug Screening Assays, Antitumor / Q000379:methods; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D066298:In Vitro Techniques; D009947:Organotin Compounds / Q000627:therapeutic use*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D009947:Organotin Compounds; C076053:di-n-butyltin(IV) trimethoxybenzoate; C076054:diethyl-n-butyltin(IV) trimethoxybenzoate; D005707:Gallic Acid