title: Plain film and CT observations in prostaglandin-induced bone changes.
abstract: Prostaglandin E1 intravenous infusion is used in infants with ductal-dependent congenital heart disease to maintain ductal patency and prolong life until palliative or corrective surgery is feasible. Complications of prostaglandin administration include fever, diarrhoea, hypotension, apnoea, bradycardia, pseudowidening of the cranial sutures, underossification of the calvarial bones, periostitis, and skin edema [1-3]. This paper presents dramatic plain radiographic features of prostaglandin-induced bone disease, including periosteal proliferation and the unusual bone-within-bone appearance, and provides the previously unpublished CT correlation.
authors.affiliation: Department of Radiology, Children's Hospital of Eastern Ontario, Ottawa, Canada.
authors.forename: M A
authors.initials: MA
authors.lastname: Matzinger
authors.forename: V A
authors.initials: VA
authors.lastname: Briggs
authors.forename: H J
authors.initials: HJ
authors.lastname: Dunlap
authors.forename: K
authors.initials: K
authors.lastname: Udjus
authors.forename: D J
authors.initials: DJ
authors.lastname: Martin
authors.forename: P
authors.initials: P
authors.lastname: McDonald
mesh_terms: D000527:Alprostadil / Q000009:adverse effects* / Q000627:therapeutic use; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D006330:Heart Defects, Congenital / Q000188:drug therapy*; D006801:Humans; D015576:Hyperostosis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D007231:Infant, Newborn; D008297:Male; D010521:Periosteum / Q000187:drug effects; D010522:Periostitis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
chemical_list: D000527:Alprostadil