Genotoxic effectivity--comparison of 36 nitrated furan and arenofuran derivatives on a quantitative scale. Statistical comparison of T7 and other short-term tests.
Thirty-six nitrated furan and arenofuran derivatives were measured and quantitatively characterized by the T7 inactivation test. A wide range of substances previously studied allowed us to compare the collected quantitative data with those obtained by other workers using different short-term tests. Based on comparative statistical evaluation of these data a borderline was determined for the genotoxic effect: compounds having in our short-term test mutagenicity index (MI) values smaller than 8.0 are positive while the higher values represent negative genotoxicity. Classification of 36 nitrofuran/nitroarenofuran derivatives is given both on the basis of the quantitative genotoxicity scale and in terms of +/- on the qualitative scale. All but one compound were found to be genotoxic and the genotoxic activities of these compounds were compared with the results of other carcinogenicity or mutagenicity tests.
Rontó
G
G
Institute of Biophysics, Semmelweis Medical University, Budapest, Hungary.
Gróf
P
P
Buisson
J P
JP
Einhorn
J
J
Demerseman
P
P
D015197:Carcinogenicity Tests; D002869:Chromosome Aberrations / Q000235:genetics*; D005663:Furans / Q000633:toxicity*; D015394:Molecular Structure; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens / Q000633:toxicity*; D009154:Mutation / Q000235:genetics; D009566:Nitrates; D009581:Nitrofurans / Q000633:toxicity; D012015:Reference Standards; D012486:Salmonella typhimurium / Q000235:genetics; D013604:T-Phages / Q000187:drug effects* / Q000235:genetics; D013997:Time Factors; D014170:Transformation, Genetic / Q000235:genetics
D005663:Furans; D009153:Mutagens; D009566:Nitrates; D009581:Nitrofurans; C030911:2-nitro-7-methoxynaphtho(2-1b)furan