title: Reversal of acute fulminant lymphocytic myocarditis with combined technology of OKT3 monoclonal antibody and mechanical circulatory support.
abstract: Reported is a case of acute fulminant lymphocytic myocarditis with profound circulatory compromise that was successfully reversed by treatment with OKT3 monoclonal antibody. The patient was supported with biventricular assist devices while being treated with the monoclonal antibody. The patient had remarkable recovery of ventricular function, which allowed for the removal of the device after 8 days of support. This case shows the success of combined technologies of monoclonal antibody and mechanical circulatory support to treat a potentially fatal disease process.
authors.affiliation: Department of Cardiothoracic Surgery, Baylor University Medical Center, Dallas, Texas 75246.
authors.forename: G K
authors.initials: GK
authors.lastname: Jett
authors.forename: A
authors.initials: A
authors.lastname: Miller
authors.forename: D
authors.initials: D
authors.lastname: Savino
authors.forename: T
authors.initials: T
authors.lastname: Gonwa
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D006353:Heart-Assist Devices; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D016853:Muromonab-CD3 / Q000627:therapeutic use*; D009205:Myocarditis / Q000473:pathology / Q000628:therapy*; D009206:Myocardium / Q000473:pathology
chemical_list: D016853:Muromonab-CD3