title: Cryosurgery of lentigo maligna.
abstract: Lentigo maligna denotes flat, pigmented lesions predominantly in areas of actinic damage that have the propensity to become malignant. More than 10 years may pass before lentigo maligna evolves into an invasive neoplasma. As an invasive process, it is termed lentigo maligna melanoma (LMM), and it has the potential for both lymphatic and hematogenic metastases. Because of the size and location of the lesions, cosmetically unsatisfactory scars may result from conventional surgery. Therefore, alternative means of treatment, including cryosurgery, have been employed. We report on 12 patients suffering from lentigo maligna who had been treated successfully by cryosurgery between 1984 and 1990. The average follow-up period was 51.4 months, and the recurrence rate was 8.3 percent. Knowing that microinvasive components can be demonstrated in 15 percent of lentigo maligna lesions, we retrospectively reassessed our patients by immunohistochemical procedures with S-100 protein. Although intradermal microinvasion could be confirmed in one patient, no recurrence had been observed within 61 months of follow-up. Provided that patients are selected properly and extension of cryonecrosis is monitored, cryosurgery may prove an efficient alternative to conventional surgery in the treatment of lentigo maligna.
authors.affiliation: Second Department of Dermatology, University of Vienna, Austria.
authors.forename: K
authors.initials: K
authors.lastname: Böhler-Sommeregger
authors.forename: S
authors.initials: S
authors.lastname: Schuller-Petrovic
authors.forename: R
authors.initials: R
authors.lastname: Neumann
authors.forename: E
authors.initials: E
authors.lastname: Müller
mesh_terms: D000368:Aged; D003452:Cryosurgery / Q000009:adverse effects / Q000379:methods; D004487:Edema / Q000209:etiology; D005148:Facial Dermatoses / Q000209:etiology; D005153:Facial Neoplasms / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D009336:Necrosis; D009364:Neoplasm Recurrence, Local / Q000473:pathology