title: Evaluation of Astroglide, a new vaginal lubricant: effects of length of exposure and concentration on sperm motility.
abstract: Traditional vaginal lubricants have been shown to adversely affect sperm motility. Astroglide, a new vaginal lubricant, and K-Y Jelly were tested at varying concentrations to assess their suitability for infertility patients requiring a lubricant. The vaginal lubricants tested impaired sperm motility in a concentration-dependent but not time-dependent manner. We conclude that all traditional vaginal lubricants should be avoided in patients desiring conception. Future studies should attempt to mimic in vivo conditions and focus on concentration-dependent effects.
authors.affiliation: Department of Obstetrics and Gynecology, University of Connecticut, Farmington.
authors.forename: G N
authors.initials: GN
authors.lastname: Frishman
authors.forename: A A
authors.initials: AA
authors.lastname: Luciano
authors.forename: D B
authors.initials: DB
authors.lastname: Maier
mesh_terms: D002482:Cellulose / Q000031:analogs & derivatives / Q000494:pharmacology; D005260:Female; D005990:Glycerol / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010710:Phosphates / Q000494:pharmacology; D011409:Propylene Glycols / Q000494:pharmacology; D012995:Solubility; D013081:Sperm Motility / Q000187:drug effects*; D013997:Time Factors; D014621:Vagina / Q000502:physiology*; D014622:Vaginal Creams, Foams, and Jellies / Q000494:pharmacology*; D014867:Water
chemical_list: C076620:Astroglide; C042973:K-Y jelly; D010710:Phosphates; D011409:Propylene Glycols; D014622:Vaginal Creams, Foams, and Jellies; D014867:Water; D002482:Cellulose; D005990:Glycerol