title: Expression of cathepsin D in head and neck cancer.
abstract: To determine overexpression of cathepsin D in head and neck tumours we examined cytosols from 53 primary tumours, nine cytosols of lymph node metastases and 12 cytosols from adjacent normal tissue. We found a significantly lower concentration in normal tissue compared with tumour cytosol as well as with metastases, even when we compared tumours and corresponding metastases pairwise. In addition, we found a significantly higher concentration of cathepsin D in five lymph node metastases than in the corresponding tumours. We conclude that the reported role of cathepsin D is not restricted to breast cancer but could also be important in head and neck cancer.
authors.affiliation: First Department of Obstetrics and Gynecology, University of Vienna, Austria.
authors.forename: R
authors.initials: R
authors.lastname: Zeillinger
authors.forename: H
authors.initials: H
authors.lastname: Swoboda
authors.forename: E
authors.initials: E
authors.lastname: Machacek
authors.forename: D
authors.initials: D
authors.lastname: Nekahm
authors.forename: G
authors.initials: G
authors.lastname: Sliutz
authors.forename: W
authors.initials: W
authors.lastname: Knogler
authors.forename: P
authors.initials: P
authors.lastname: Speiser
authors.forename: E
authors.initials: E
authors.lastname: Swoboda
authors.forename: E
authors.initials: E
authors.lastname: Kubista
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002402:Cathepsin D / Q000096:biosynthesis*; D003600:Cytosol / Q000378:metabolism*; D005260:Female; D006258:Head and Neck Neoplasms / Q000378:metabolism*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male
chemical_list: D014408:Biomarkers, Tumor; D002402:Cathepsin D