Failure to reduce experimental myocardial infarct size with ibuprofen pre-treatment in rats.
The prophylactic role of ibuprofen in experimental myocardial infarction has not been reported. Twenty-four rats pre-treated with ibuprofen (30 mg/kg), po, for 21 days were subjected to myocardial infarction by administration of isoprenaline hydrochloride (85 mg/kg), sc, on two consecutive days. An equal number of rats were given saline to serve as control. Heart specimens were taken for macroscopic and microscopic examination after 1 day, 5 days, 12 days and 21 days, following myocardial infarction. Ibuprofen pre-treatment caused a significant increase in infarct size at all the intervals studied (P less than 0.01), indicating that ibuprofen exerted a harmful effect in increasing the size of experimental myocardial infarction.
Lal
A
A
Department of Pharmacology, M.G.I.M.S., Distt. Wardha, Maharashtra State.
Sharma
M L
ML
D000818:Animals; D005260:Female; D006321:Heart / Q000187:drug effects*; D007052:Ibuprofen / Q000008:administration & dosage / Q000494:pharmacology*; D007545:Isoproterenol / Q000633:toxicity; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D009206:Myocardium / Q000473:pathology; D051381:Rats
D007545:Isoproterenol; D007052:Ibuprofen