title: Effects of some natural products on sugar cataract studied with nuclear magnetic resonance spectroscopy.
abstract: Four commercial anticataract drugs and five flavonoids isolated from Chinese herbs were studied on their effects to inhibit sugar cataract formation in vitro using 13C-nuclear magnetic resonance spectroscopy (MRS). Pa-Wei-Di-Huan-Wan (PWDHW) and Zhang-Yan-Ming (ZYM) were effective in inhibiting sorbitol formation, whereas Bai-Nei-Ting (BNT) and Pearl Min-Mu-Ye (Pearl MMY) were ineffective in inhibiting sorbitol formation. Among five flavonoids tested, four were moderately effective in inhibiting sorbitol formation, and one was totally ineffective up to 1 x 10(-4)M used.
authors.affiliation: Institute of Ocular Pharmacology, Texas A&M University, College Station.
authors.forename: G C
authors.initials: GC
authors.lastname: Chiou
authors.forename: N J
authors.initials: NJ
authors.lastname: Stolowich
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Zheng
authors.forename: Z F
authors.initials: ZF
authors.lastname: Shen
authors.forename: M
authors.initials: M
authors.lastname: Zhu
authors.forename: Z D
authors.initials: ZD
authors.lastname: Min
mesh_terms: D000818:Animals; D002247:Carbon Isotopes; D002386:Cataract / Q000209:etiology / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005415:Flavins / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D007908:Lens, Crystalline / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D011817:Rabbits; D013012:Sorbitol / Q000037:antagonists & inhibitors*
chemical_list: D002247:Carbon Isotopes; D004365:Drugs, Chinese Herbal; D005415:Flavins; D013012:Sorbitol; D005947:Glucose