Subchronic oral administration of acemannan in the rat and dog.
Acemannan is the USAN-accepted name for long-chain polydispersed beta-(1,4)-acetylated polymannose with interspersed O-acetyl groups, with a mannose monomer/acetyl ratio of approximately 1:1. This complex polysaccharide is extracted from Aloe vera (barbadensis Miller); the technical material contains approximately 78% acemannan. Technical grade acemannan was administered po to rats for 14 d at 5% of the diet and for 6 mo at up to 2,000 mg/kg/d, and to beagle dogs for 90 d at up to 1,500 mg/kg/d without significant effect on any parameter measured in either species.
Fogleman
R W
RW
Carrington Laboratories, Dallas, TX 75356.
Shellenberger
T E
TE
Balmer
M F
MF
Carpenter
R H
RH
McAnalley
B H
BH
D000284:Administration, Oral; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D004285:Dogs; D004341:Drug Evaluation; D004435:Eating / Q000187:drug effects; D005260:Female; D008297:Male; D008351:Mannans / Q000008:administration & dosage / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000187:drug effects
D000998:Antiviral Agents; D008351:Mannans; C058414:acemannan