title: Influence of buffered and unbuffered acetylsalicylic acid on dental enamel and dentine in human teeth: an in vitro pilot study.
abstract: An in vitro study was conducted to investigate the erosive effect of buffered and unbuffered acetylsalicylic acid (ASA) on dental enamel and dentine in human teeth by scanning electron microscopy. In order to standardize the specimens and to improve comparability the dental enamel and dentine were superficially abraded. The enamel and dentine specimens were therefore particularly sensitive to the influences of acid agents. Concentrated solution of buffered chewable ASA tablets (500 mg ASA and 300 mg calcium carbonate in 5 ml water) showed no changes in the enamel surface structure after exposure times of 1 min, 5 min and 60 min. In contrast, minimal corrosive effects were already seen after exposure of the enamel surface to the unbuffered ASA solutions for 1 min. After exposure times of 5 min and 60 min erosion of the enamel was more pronounced. Immersion in the unbuffered ASA solution led to clearly visible micromorphological changes on the dentine surfaces even after exposure for 1 min. Exposure of the dentine specimens to the buffered ASA solutions led to only very slight changes in the surface morphology. Therefore, the scanning electron micrograph after exposure to buffered ASA is comparable to the picture of untreated dentine.
authors.affiliation: Pharmaforschungszentrum, Bayer AG, Wuppertal, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Rogalla
authors.forename: W
authors.initials: W
authors.lastname: Finger
authors.forename: M
authors.initials: M
authors.lastname: Hannig
mesh_terms: D001241:Aspirin / Q000494:pharmacology*; D002021:Buffers; D003743:Dental Enamel / Q000187:drug effects* / Q000648:ultrastructure; D003804:Dentin / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008855:Microscopy, Electron, Scanning
chemical_list: D002021:Buffers; D001241:Aspirin