title: [Genotoxicity of the preparation "binase" in tests on Salmonella: Ames test and ARA-test].
abstract: The present work deals with mutagenicity determination of enzyme sample "binase" (Bacillus intermedius ribonuclease) in microbial test-systems: Ames test and Ara-test. The weak mutagenic effect of "binase" high concentration was established in both tests by induction of forward Ara-mutations and Histidine-reverse mutations. A metabolic activation is seen to remove this effect.
authors.forename: O B
authors.initials: OB
authors.lastname: Ivanchenko
authors.forename: O N
authors.initials: ON
authors.lastname: Il'inskaia
authors.forename: N S
authors.initials: NS
authors.lastname: Karamova
mesh_terms: D001089:Arabinose / Q000494:pharmacology; D004352:Drug Resistance, Microbial / Q000235:genetics; D004722:Endoribonucleases / Q000633:toxicity*; D006639:Histidine / Q000235:genetics; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000235:genetics*
chemical_list: D009153:Mutagens; D006639:Histidine; D001089:Arabinose; D004722:Endoribonucleases; C022543:ribonuclease T(2)
vernacular_title: Genotoksichnost' preparata "binaza" v testakh na Salmonella: test Eĭmsa i Ara-test.