title: The efficacy of an albendazole intraruminal controlled-release device against gastrointestinal parasitism in lambs.
abstract: The effectiveness of albendazole in a controlled-release bolus in controlling gastrointestinal nematodes in lambs was assessed during the summer of 1986. Faecal egg counts were almost entirely negative throughout in the treated group and larval challenge remained low at below 2000 larvae kg-1. Untreated control lambs showed a characteristic pattern of auto-infection, culminating in a peak pasture larval count of over 70,000 larvae kg-1 and an outbreak of parasitic gastroenteritis in September associated with a serum pepsinogen concentration of 1.183 IU tyrosine and a mean worm burden of 91,165 nematodes at necropsy, including Ostertagia, Trichostrongylus and Nematodirus species. Subject to the restrictions imposed by the size of the bolus, this was considered to be a highly effective method of seasonal parasite control.
authors.affiliation: Department of Agriculture, University of Newcastle upon Tyne, UK.
authors.forename: S L
authors.initials: SL
authors.lastname: Bell
authors.forename: R J
authors.initials: RJ
authors.lastname: Thomas
mesh_terms: D000018:Abomasum / Q000469:parasitology; D015766:Albendazole / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D001835:Body Weight; D003692:Delayed-Action Preparations; D005243:Feces / Q000469:parasitology; D007411:Intestinal Diseases, Parasitic / Q000517:prevention & control / Q000662:veterinary*; D007421:Intestine, Small / Q000469:parasitology; D010270:Parasite Egg Count / Q000662:veterinary; D010435:Pepsinogens / Q000097:blood; D012756:Sheep; D012757:Sheep Diseases / Q000517:prevention & control*
chemical_list: D003692:Delayed-Action Preparations; D010435:Pepsinogens; D015766:Albendazole