Psammaplysin C: a new cytotoxic dibromotyrosine-derived metabolite from the marine sponge Druinella (= Psammaplysilla) purpurea.
The new, cytotoxic dibromotyrosine-derived metabolite psammaplysin C [3], in addition to the two known psammaplysins A [1] and B [2], was isolated from the marine sponge Druinella purpurea. All three compounds were found to possess moderate in vitro cytotoxicity towards the human colon tumor cell-line HCT116.
Copp
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Department of Medicinal Chemistry, University of Utah, Salt Lake City 84112.
Ireland
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Barrows
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D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D003110:Colonic Neoplasms / Q000188:drug therapy; D011161:Porifera / Q000737:chemistry*; D013141:Spiro Compounds / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology
D000970:Antineoplastic Agents; D013141:Spiro Compounds; C076602:psammaplysin C; D014443:Tyrosine