Pharmacotherapy of multiple sclerosis: current status.
Pharmacotherapy plays an important part in the overall management of patients with multiple sclerosis. Most therapies directed at altering the natural history of the underlying disease process are only partially effective or are controversial or experimental. However, many effective symptomatic therapies are available to the clinician. The action and uses of corticosteroids in multiple sclerosis are discussed, and approaches to the treatment of spasticity, paroxysmal disorders, bladder dysfunction, cerebellar ataxia, neurobehavioral manifestations, fatigue, and acute and chronic pain in patients with multiple sclerosis are examined.
Rudick
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RA
Mellen Center for Multiple Sclerosis Treatment and Research, Department of Neurology, Cleveland Clinic Foundation, OH 44195.
Goodkin
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DE
Ransohoff
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RM
D000208:Acute Disease; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D001007:Anxiety / Q000150:complications / Q000188:drug therapy; D001418:Baclofen / Q000627:therapeutic use; D002524:Cerebellar Ataxia / Q000150:complications / Q000188:drug therapy; D002908:Chronic Disease; D003620:Dantrolene / Q000627:therapeutic use; D003863:Depression / Q000150:complications / Q000188:drug therapy; D003975:Diazepam / Q000627:therapeutic use; D004421:Dystonia / Q000150:complications / Q000188:drug therapy; D005221:Fatigue / Q000150:complications / Q000188:drug therapy; D006801:Humans; D009103:Multiple Sclerosis / Q000150:complications / Q000188:drug therapy*; D009128:Muscle Spasticity / Q000150:complications / Q000188:drug therapy; D010146:Pain / Q000150:complications / Q000188:drug therapy; D012640:Seizures / Q000150:complications / Q000188:drug therapy; D013997:Time Factors; D001745:Urinary Bladder Diseases / Q000150:complications / Q000188:drug therapy
D000305:Adrenal Cortex Hormones; D003620:Dantrolene; D001418:Baclofen; D003975:Diazepam