title: Clinical evaluation of quinacrine pellets for chemical female sterilization.
abstract: Under the auspices of the Coordinating Board of Indonesian Fertility Research (BKS PENFIN), a clinical trial was undertaken to examine the safety and effectiveness of the quinacrine pellet method for nonsurgical female sterilization. One hundred women were selected to receive 3 monthly insertions of 250 mg of quinacrine and were followed up at 1, 3, 6 and 12 months after the third insertion. Socioeconomic data and complaints and menstrual patterns at each insertion and every follow-up visit were recorded, as were all failures. The life-table failure rate was determined to be 3.1. The continuation rate in this study was 96% at 1 year. Just over one-fifth of the women had amenorrhea by the third insertion, but most returned to normal by 1 year, and it appears that this amenorrhea was transient in nature. The method proved to be safe and effective, suggesting that larger clinical trials are in order.
authors.affiliation: Department of Obstetrics and Gynecology, Hasan Sadikin Hospital, Bandung, Indonesia.
authors.forename: T
authors.initials: T
authors.lastname: Agoestina
authors.forename: I
authors.initials: I
authors.lastname: Kusuma
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D004343:Drug Implants; D004522:Educational Status; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015993:Life Tables; D008297:Male; D008597:Menstrual Cycle / Q000187:drug effects; D011247:Pregnancy; D011796:Quinacrine / Q000009:adverse effects; D012923:Social Class; D013245:Sterilization, Reproductive; D016896:Treatment Outcome
chemical_list: D004343:Drug Implants; D011796:Quinacrine