Chromosomal assignment of human phenol and bilirubin UDP-glucuronosyltransferase genes (UGT1A-subfamily).
DNA probes were prepared from the 5'-terminal portion of four cDNA clones encoding human phenol and bilirubin UDP-glucuronosyltransferases (UGTs). An additional sequence common to all four clones was isolated from the 3'-terminal portion of one of the clones (UGT1A1). The four specific and the one common DNA sequences were used as probes on a panel of 16 human--rodent somatic cell hybrid DNAs by Southern-blot analysis. The results obtained indicate that all four cDNA clones are encoded by gene(s) located on human chromosome 2.
Moghrabi
N
N
University Department of Biochemical Medicine, Ninewells Hospital and Medical School, Dundee, Scotland.
Sutherland
L
L
Wooster
R
R
Povey
S
S
Boxer
M
M
Burchell
B
B
D000818:Animals; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D015342:DNA Probes; D014453:Glucuronosyltransferase / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D051381:Rats
D015342:DNA Probes; D014453:Glucuronosyltransferase