A thyroid biopsy with histologic features of both Riedel's thyroiditis and the fibrosing variant of Hashimoto's thyroiditis.
We describe a 36-year-old woman with clinical, laboratory, and histologic features of both Riedel's thyroiditis and the fibrosing variant of Hashimoto's thyroiditis. Features of the former included a hard, fixed thyroid mass and extensive involvement of perithyroidal tissues by dense fibrosis with lymphocytes, histiocytes, and plasma cells. Features supporting Hashimoto's thyroiditis included high serum titers of antimicrosomal and antithyroglobulin antibodies and the histologic findings within the thyroid gland itself: dense fibrous bands dividing the thyroid parenchyma into nodules composed of lymphoid follicles with germinal centers, plasma cells, and oxyphilic metaplasia of follicular epithelial cells. Although Riedel's thyroiditis and the fibrosing variant of Hashimoto's thyroiditis were once considered morphologic variants of the same disease, since the 1970s these diseases have been considered as distinct clinicopathologic entities. The coexistence of both diseases in a patient is rare and is probably coincidental in this instance.
Taubenberger
J K
JK
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Merino
M J
MJ
Medeiros
L J
LJ
D000328:Adult; D001706:Biopsy; D005260:Female; D005355:Fibrosis; D006801:Humans; D007150:Immunohistochemistry; D013961:Thyroid Gland / Q000473:pathology*; D013966:Thyroiditis / Q000145:classification / Q000378:metabolism / Q000473:pathology*; D013967:Thyroiditis, Autoimmune / Q000473:pathology*