title: Effect of radiation on some haematological parameters and its modification by vitamin E in chicks.
abstract: White leghorn male chicks of 1 and 7 day age groups were studied for acute (2.25 Gy) gamma radiation (with or without vit. E pretreatment) induced haematological changes in the peripheral blood at days 1, 3, 5, 7, 14 and 28 postirradiation. A continuous decrease in the erythrocyte numbers was observed in the animals irradiated without vit. E treatment. The changes in haematocrit, haemoglobin, MCV, MCH and MCHC values were in line with the erythrocytic changes reflecting radiation induced damage to the erythroid elements. Animals pretreated with vit. E show lesser depression in the erythrocytic component at all the stages indicating its radio-protective influence. The significant increase in the immature RBC's in the peripheral blood in vit. E treated animals after irradiation, implies enhanced erythropoiesis.
authors.affiliation: Department of Bio-Sciences, Himachal Pradesh University, Summer Hill, Shimla, India.
authors.forename: K
authors.initials: K
authors.lastname: Rana
authors.forename: N
authors.initials: N
authors.lastname: Malhotra
authors.forename: R K
authors.initials: RK
authors.lastname: Malhotra
mesh_terms: D000818:Animals; D002645:Chickens; D004912:Erythrocytes / Q000187:drug effects* / Q000528:radiation effects*; D005720:Gamma Rays / Q000009:adverse effects; D008297:Male; D011839:Radiation, Ionizing; D013997:Time Factors; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D014810:Vitamin E