Pharmacodynamic effects of Sandostatin in the gastrointestinal tract.
Somatostatin (SST) is widely distributed throughout the human gastrointestinal system. There, it is found in neurons and fibers of both the submucosal and myenteric plexus and the pancreas, and also in the D cells of the stomach, gut, and pancreatic islets. Whereas in the intestinal nervous system, duodenum, and pancreas, somatostatin-14 (SST-14) appears to be the predominant molecular form, the endocrine-type D cells of the intestine primarily contain somatostatin-28 (SST-28). SST peptides may act very differently at different sites, as hormones, paracrine substances, or neurotransmitters. Because of this complexity of action, very little is known about the physiological effects of SST in the gastrointestinal tract. In contrast, the pharmacological actions of natural synthetic SST have been thoroughly studied and have given rise to many therapeutic applications. Octreotide, an analogue with a longer half-life and higher potency, has greatly facilitated the clinical application of SST. This review deals with the pharmacological effects of octreotide on different gastrointestinal functions. The SST analogue exerts a long-lasting inhibitory action on gastric acid, pancreatic enzyme, bicarbonate secretion, and on bile flow. It also inhibits stimulated intestinal secretion, ie, the release of neuropeptides from the gut and pancreas. It can also prolong orocecum transit time and prevent gallbladder contraction. It inhibits absorption of nutrients and exerts inhibitory effects on splanchnic hemodynamics. It is because of these actions that SST has attracted so much attention in the treatment of different gastrointestinal disorders.
Gyr
K E
KE
Medical Department, Kantonsspital Liestal, University of Basel, Switzerland.
Meier
R
R
D001692:Biological Transport; D004064:Digestive System / Q000187:drug effects* / Q000378:metabolism; D005750:Gastric Juice / Q000378:metabolism; D005768:Gastrointestinal Hormones / Q000378:metabolism; D005769:Gastrointestinal Motility / Q000187:drug effects; D006439:Hemodynamics; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D015282:Octreotide / Q000494:pharmacology*; D010179:Pancreas / Q000187:drug effects; D013152:Splanchnic Circulation / Q000187:drug effects; D013270:Stomach / Q000187:drug effects; D014882:Water-Electrolyte Balance / Q000187:drug effects
D005768:Gastrointestinal Hormones; D015282:Octreotide