Microcolins A and B, new immunosuppressive peptides from the blue-green alga Lyngbya majuscula.
Microcolin A [1] and microcolin B [2] are new immunosuppressive lipopeptides isolated from a Venezuelan sample of the blue-green alga Lyngbya majuscula. The microcolins are potent inhibitors of the murine mixed lymphocyte response and murine P-388 leukemia in vitro. Isolation and structure elucidation of 1 and 2 by nmr, mass spectral, and chemical methods are described.
Koehn
F E
FE
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Inc., Ft. Pierce, Florida 34946.
Longley
R E
RE
Reed
J K
JK
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000458:Cyanobacteria / Q000737:chemistry*; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007941:Leukemia P388; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009842:Oligopeptides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011759:Pyrrolidines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D009842:Oligopeptides; D011759:Pyrrolidines; C076335:microcolin A; C076336:microcolin B