Increase in c-fos-like immunoreactivity in the trigeminal nucleus complex after dental treatment.
An immunohistochemical study was made of the temporal changes in the expression of the c-fos oncogene protein in the spinal trigeminal nucleus complex (STNC) after three different types of dental injury. One hour after tooth extraction or pulp exposure, c-fos neurons appeared in the ipsilateral subnucleus caudalis, but there were very few c-fos neurons in the ipsilateral subnuclei oralis and interpolaris, and in the trigeminal main sensory nucleus and contralateral STNC. The great number of c-fos neurons was found 2-4 hours after injury, levels decreased by 8 hours after injury. Twenty-four hours after injury, the number of these neurons in subnucleus caudalis became very small. Shallow cavity preparation, however, did not induce an increase in the number of c-fos neurons at any selected postoperative time in STNC. These results indicate that c-fos neurons appear mainly in subnucleus caudalis very soon after severe dental injury.
Wakisaka
S
S
First Department of Oral Anatomy, Osaka University Faculty of Dentistry, Japan.
Sasaki
Y
Y
Ichikawa
H
H
Matsuo
S
S
D000818:Animals; D002467:Cell Nucleus / Q000737:chemistry; D003737:Dental Cavity Preparation; D003782:Dental Pulp / Q000737:chemistry / Q000294:innervation*; D003789:Dental Pulp Exposure; D008297:Male; D009434:Neural Pathways / Q000737:chemistry / Q000648:ultrastructure; D009474:Neurons / Q000737:chemistry / Q000648:ultrastructure; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014081:Tooth Extraction; D014279:Trigeminal Nucleus, Spinal / Q000737:chemistry* / Q000648:ultrastructure
D016760:Proto-Oncogene Proteins c-fos