title: D21S215 is a (GT)n polymorphic marker close to centromeric alphoid sequences on chromosome 21.
abstract: A plasmid, AWZ1, that contained a dinucleotide (GT)n repeat was identified from a chromosome 21-specific genomic library. When amplified by PCR from human genomic DNA, the repeat length was highly polymorphic between individuals; its location, D21S215, was mapped in the CEPH pedigrees by linkage analysis to the pericentromeric region of chromosome 21. It is the closest polymorphic marker to alphoid sequences on this chromosome.
authors.affiliation: Center for Medical Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
authors.forename: A C
authors.initials: AC
authors.lastname: Warren
authors.forename: M B
authors.initials: MB
authors.lastname: Petersen
authors.forename: W
authors.initials: W
authors.lastname: Van Hul
authors.forename: M G
authors.initials: MG
authors.lastname: McInnis
authors.forename: C
authors.initials: C
authors.lastname: Van Broeckhoven
authors.forename: T K
authors.initials: TK
authors.lastname: Cox
authors.forename: A
authors.initials: A
authors.lastname: Chakravarti
authors.forename: S E
authors.initials: SE
authors.lastname: Antonarakis
mesh_terms: D000818:Animals; D001483:Base Sequence; D002503:Centromere; D002891:Chromosomes, Human, Pair 21; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D009841:Oligonucleotides; D010957:Plasmids; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D005819:Genetic Markers; D009841:Oligonucleotides