Decreased behavioral effects of daily intracerebroventricular bombesin.
Intracerebroventricular (ICV) bombesin increases grooming and decreases food intake in rats. We examined tolerance to these effects by administering a daily injection of either saline or 25 ng bombesin to rats for 8 days via lateral ventricular cannulas. Food intake and grooming were monitored. After 8 days bombesin no longer increased grooming or decreased food intake in bombesin-treated rats, but did increase grooming and decrease food intake in saline-treated rats. This development of behavioral tolerance conflicts with previous reports using larger doses and demonstrates that repeated small doses of ICV bombesin produce different effects from larger doses.
Corwin
R L
RL
Department of Psychiatry, Cornell University Medical College, White Plains, NY.
Corp
E S
ES
Gibbs
J
J
Smith
G P
GP
D000818:Animals; D001839:Bombesin / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D004361:Drug Tolerance; D005247:Feeding Behavior / Q000187:drug effects*; D006120:Grooming / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D001839:Bombesin