Overgrowth and pruning of dendrites in adult rats recovering from neocortical damage.
Unilateral lesions to the forelimb representation (FL) area of the rat sensorimotor cortex caused a time-dependent increase in the dendritic arborization of layer V pyramidal neurons in the contralateral homotopic cortex. The increase in arborization was maximum at 2-3 weeks after the lesion, following which there was a partial reduction in dendritic branching. These neural morphological changes may be related to post-lesion behavioral changes in the use of the forelimbs.
Jones
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Department of Psychology, University of Texas, Austin 78712.
Schallert
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D000704:Analysis of Variance; D000818:Animals; D002755:Choice Behavior / Q000502:physiology*; D003712:Dendrites / Q000502:physiology*; D008297:Male; D009473:Neuronal Plasticity / Q000502:physiology*; D051381:Rats; D013003:Somatosensory Cortex / Q000293:injuries / Q000502:physiology*