[The diagnostic value of the histamine test in studying the gastric juice of patients with duodenal peptic ulcer].
Measurements were made of the content of pepsin and hydrochloric acid in gastric juice from 96 duodenal ulcer patients, obtained under the conditions of basal secretion and after histamine administration in the submaximal dose. The disease was marked by changes in the response to histamine on the part of gastric glands. In duodenal ulcer patients, histamine primarily stimulates pepsin secretion whereas in healthy subjects, secretion of hydrochloric acid is predominant. Based on the regularity thus revealed, a new test (the ratio of the histamine index of pepsin to the histamine index of hydrochloric acid) was developed. This test is of importance for the diagnosis of duodenal ulcer and predicting the gravity of the course it may run.
Starostenko
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D000293:Adolescent; D000328:Adult; D002764:Cholecystitis / Q000175:diagnosis; D002908:Chronic Disease; D004381:Duodenal Ulcer / Q000175:diagnosis*; D005260:Female; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000737:chemistry / Q000187:drug effects*; D005756:Gastritis / Q000175:diagnosis; D006632:Histamine; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000175:diagnosis; D010434:Pepsin A / Q000032:analysis / Q000187:drug effects; D013268:Stimulation, Chemical
D006632:Histamine; D010434:Pepsin A
Diagnosticheskaia tsennost' gistaminovogo testa pri issledovanii zheludochnogo soka bol'nykh iazvennoĭ bolezn'iu dvenadtsatiperstnoĭ kishki.