title: Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans.
abstract: We have determined the chromosomal location of seven human neuronal nicotinic acetylcholine receptor subunit genes by genomic Southern analysis of hamster/human somatic cell hybrid DNAs. The beta 2 subunit gene was localized to human chromosome 1, the alpha 2 and beta 3 subunit genes were localized to human chromosome 8, the alpha 3, alpha 5, and beta 4 subunit genes were localized to human chromosome 15, and the alpha 4 subunit gene was localized to human chromosome 20. Mapping of the beta 2 subunit gene to chromosome 1 establishes a syntenic group with the amylase gene locus on human chromosome 1 and mouse chromosome 3, while mapping of the alpha 3 subunit gene to chromosome 15 confirms the existence of a syntenic group with the mannose phosphate isomerase gene locus on human chromosome 15 and mouse chromosome 9.
authors.affiliation: David Mahoney Institute of Neurological Sciences, University of Pennsylvania, Philadelphia 19104-6074.
authors.forename: R
authors.initials: R
authors.lastname: Anand
authors.forename: J
authors.initials: J
authors.lastname: Lindstrom
mesh_terms: D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002884:Chromosomes, Human, Pair 15; D002898:Chromosomes, Human, Pair 8; D006224:Cricetinae; D004247:DNA; D015342:DNA Probes; D006801:Humans; D006822:Hybrid Cells; D009474:Neurons / Q000378:metabolism*; D011978:Receptors, Nicotinic / Q000235:genetics*
chemical_list: D015342:DNA Probes; D011978:Receptors, Nicotinic; D004247:DNA