title: [Combined gu chi wan and spiramycin in the treatment of periodontal disease].
abstract: The purpose of the present study is to evaluate clinical effect of the integrated traditional Chinese and western medicine in the treatment of periodontal disease. 90 patients suffered from mild to advanced periodontitis were divided into two groups. The gu chi wan (tooth firming pills) group was administered tooth firming pills 4 mg twice daily for 3-6 months combined with spiramycin 0.2 four times daily for 5 days and routine periodontal treatment. The spiramycin group, as control, was administered spiramycin 0.2 four times daily for 5 days combined with routine periodontal treatment. The clinical parameters: GI, PLI, PDI and serial radiographs were checked on the beginning of study and through 3, 6, 12, 24 months follow up study. The results showed that the GI and PDI of the gu chi wan group decreased significantly than the control group (P less than 0.001). The inflammatory recurrence rate was 33% in the control group and 12% in gu chi wan group and the serial radiographs demonstrated that a higher incidence of bone fill occurred in gu chi wan group than in the control group (P less than 0.01).
authors.affiliation: College of Stomatology, West China University of Medical Sciences, Chengdu.
authors.forename: J Z
authors.initials: JZ
authors.lastname: Zhang
authors.forename: X X
authors.initials: XX
authors.lastname: Yang
authors.forename: Y H
authors.initials: YH
authors.lastname: Tong
mesh_terms: D000293:Adolescent; D000328:Adult; D010520:Aggressive Periodontitis / Q000188:drug therapy; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D010518:Periodontitis / Q000188:drug therapy*; D011897:Random Allocation; D012008:Recurrence; D015572:Spiramycin / Q000627:therapeutic use*
chemical_list: D004365:Drugs, Chinese Herbal; D015572:Spiramycin