title: Suppression by 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil of preneoplastic mammary hyperplastic alveolar nodule formation in SHN virgin mice.
abstract: It is known that hyperplastic alveolar nodule (HAN) is a representative preneoplastic state in mammary glands of mice. We examined the effect of 1-(2-tetrahydrofuryl)-5-fluorouracil and uracil (UFT) on HAN formation in a high mammary tumour strain of SHN virgin mice. Oral administration of UFT for 5 months beginning at one month of age significantly reduced the number of HAN and DNA-synthesizing enzyme activities in the mammary glands. These results indicate that long-term administration of low dose UFT reduces the de novo and salvage synthesis of DNA and suppresses preneoplastic HAN.
authors.affiliation: Medical Research Institute, Tokyo Medical and Dental University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Sakamoto
authors.forename: M
authors.initials: M
authors.lastname: Mizuno
authors.forename: K
authors.initials: K
authors.lastname: Sawaki
authors.forename: H
authors.initials: H
authors.lastname: Kudo
authors.forename: N
authors.initials: N
authors.lastname: Kasahara
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Mori
authors.forename: H
authors.initials: H
authors.lastname: Nagasawa
mesh_terms: D000818:Animals; D005260:Female; D006128:Growth / Q000187:drug effects; D006965:Hyperplasia / Q000188:drug therapy / Q000201:enzymology; D008321:Mammary Glands, Animal / Q000201:enzymology / Q000473:pathology*; D015674:Mammary Neoplasms, Animal / Q000188:drug therapy* / Q000201:enzymology; D051379:Mice; D008815:Mice, Inbred Strains; D011230:Precancerous Conditions / Q000188:drug therapy* / Q000201:enzymology; D005641:Tegafur / Q000008:administration & dosage / Q000627:therapeutic use*; D013937:Thymidine Kinase / Q000378:metabolism; D013940:Thymidylate Synthase / Q000378:metabolism; D014498:Uracil / Q000627:therapeutic use*
chemical_list: D005641:Tegafur; D014498:Uracil; D013940:Thymidylate Synthase; D013937:Thymidine Kinase