title: Clinical, historic, and therapeutic features of aphthous stomatitis. Literature review and open clinical trial employing steroids.
abstract: The clinical and historic features of 50 patients with diagnosed aphthous stomatitis and treated with topical triamcinolone acetonide, 0.1% or 0.2% aqueous suspension; alone or in combination with initial burst therapy of 40 to 60 mg of prednisone, are reviewed. The mean age of our patients was 36.6 years (range 6 to 80 years). The duration of the chief complaint, usually oral pain, or more specifically, recurrent oral ulcers, was 11.1 years (range 4 weeks to 40 years). All patients showed a wide range of ulcer sizes when examined initially or at follow-up. Forty were followed up for an average of 22.9 months. Thirty-four reported prompt healing of ulcers identified at the time of initial evaluation, and no or markedly fewer ulcers subsequently if maintenance therapy of prophylactic topical triamcinolone, 0.1% or 0.2% aqueous rinse, was used. Five patients reported partial relief. No systemic side effects were noted even after long-term topical therapy. Local candidosis was a complication encountered in five patients.
authors.affiliation: Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City.
authors.forename: S D
authors.initials: SD
authors.lastname: Vincent
authors.forename: G E
authors.initials: GE
authors.lastname: Lilly
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage; D013281:Stomatitis, Aphthous / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D014222:Triamcinolone Acetonide / Q000627:therapeutic use
chemical_list: D014222:Triamcinolone Acetonide; D011241:Prednisone