title: Adipostatins A and B, new inhibitors of glycerol-3-phosphate dehydrogenase.
abstract: As a result of screening for inhibitors of glycerol-3-phosphate dehydrogenase, which may be effective to prevent corpulence, we isolated two inhibitors named adipostatin A and adipostatin B from the culture broth of Streptomyces cyaneus 2299-SV1. Their structures have been established to be 5-n-pentadecylresorcinol and 5-isopentadecylresorcinol, respectively. Adipostatin A and adipostatin B inhibited glycerol-3-phosphate dehydrogenase at the IC50 values of 4.1 microM and 4.5 microM, respectively. These compounds prevented triglyceride accumulation in 3T3-L1 cells at a concentration of the microM level.
authors.affiliation: Research Institute of House Food Ind. Co., Ltd., Osaka, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Tsuge
authors.forename: M
authors.initials: M
authors.lastname: Mizokami
authors.forename: S
authors.initials: S
authors.lastname: Imai
authors.forename: A
authors.initials: A
authors.lastname: Shimazu
authors.forename: H
authors.initials: H
authors.lastname: Seto
mesh_terms: D016475:3T3 Cells; D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism; D005993:Glycerolphosphate Dehydrogenase / Q000037:antagonists & inhibitors*; D051379:Mice; D012118:Resorcinols / Q000737:chemistry / Q000378:metabolism*; D013302:Streptomyces / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D012118:Resorcinols; C076083:adipostatin B; D005993:Glycerolphosphate Dehydrogenase; C041328:adipostatin A