[Effect of chemotherapy on the antibody response to A60 antigen].
BACKGROUND
Study of the serologic response in two groups of patients with pulmonary tuberculosis: with and without treatment.


METHODS
Antibodies (type IgG) against the A60 antigen were studied in 103 patients with pulmonary tuberculosis: 46 without specific treatment and 57 after the application of the chemotherapy.


RESULTS
81.6% of the patients showed antibodies against the A60 antigen and 60.2% were strongly positive; 32.6% and 41.3% of the patients without treatment were negative and strongly positive respectively. In the patients with treatment this results were 7% and 75.4%. The differences found between both groups were statistically significant (p less than 0.001).


CONCLUSIONS
It is concluded that the application of the specific treatment modify in a high percentage the response of antibody against A60 antigen and which reduced the false negatives response, this fact could condition the clinic utility of the test.
Ladrón de Guevara
M C
MC
Servicio de Microbiología, Hospital La Paz, Madrid.
Beltrán
M
M
Gutiérrez
A
A
Saz
J V
JV
D000907:Antibodies, Bacterial / Q000096:biosynthesis* / Q000097:blood / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology*; D000995:Antitubercular Agents / Q000494:pharmacology*; D004797:Enzyme-Linked Immunosorbent Assay; D005188:False Negative Reactions; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis* / Q000097:blood / Q000276:immunology; D009163:Mycobacterium bovis / Q000276:immunology*; D013268:Stimulation, Chemical; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000276:immunology*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D000995:Antitubercular Agents; D007074:Immunoglobulin G; C055539:mycobacterial A60 antigen
Influencia de la quimioterapia en la respuesta de anticuerpos frente al antígeno A60.