Concentration and uptake of taurine in umbilical blood platelets.
The concentration and uptake of taurine in the umbilical and adult blood platelets were studied. Taurine was the most abundant free amino acid in both umbilical and adult blood platelets. The taurine concentration in umbilical blood platelets (2.30 pmoles/10(4) cells) was significantly lower than that of adult blood platelets (3.27 pmoles/10(4) cells) in contrast to the reverse relationship in taurine concentrations in umbilical and adult blood plasma. No other amino acid showed such significant difference in the concentrations between umbilical and adult blood platelets. Taurine uptake into umbilical blood platelets was temperature sensitive and sodium-dependent in a manner similar to that of adult blood platelets. The uptake conformed well to Hanes-plot. The Vmax of the uptake into adult blood platelets was about 3.6 times higher than that of umbilical blood platelets, but no significant difference was seen in the Km value between the two groups.
Kanemori
H
H
Department of Obsterics and Gynecology, Okayama University Medical School, Japan.
Ejiri
K
K
Akahori
S
S
Kudo
T
T
Sekiba
K
K
D000596:Amino Acids / Q000097:blood; D001792:Blood Platelets / Q000737:chemistry / Q000378:metabolism*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D011247:Pregnancy; D013654:Taurine / Q000097:blood* / Q000378:metabolism; D013696:Temperature
D000596:Amino Acids; D013654:Taurine