Study on the influence of adsorbent substances against the antigen activity of inactivated orovaccines.
Specific IgAGM, IgA and IgG levels were evaluated in two groups of rabbits orally treated with inactivated vaccine consisting of Escherichia coli, Proteus vulgaris, Staphylococcus aureus and Streptococcus faecalis and with the same vaccine supplemented with charcoal and kaolin, respectively. The determinations demonstrated that charcoal and kaolin do not have a significant, negative effect on immunoresponses at the intestinal and hematic level after both medium (two-week) and prolonged (four-week) treatment.
Casetta
P
P
Institute of Pharmacological Sciences, University of Milan, Italy.
Negretti
F
F
D000284:Administration, Oral; D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D001428:Bacterial Vaccines / Q000276:immunology / Q000494:pharmacology*; D002606:Charcoal / Q000494:pharmacology*; D013293:Enterococcus faecalis / Q000276:immunology; D004926:Escherichia coli / Q000276:immunology; D005243:Feces / Q000737:chemistry; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007136:Immunoglobulins / Q000276:immunology; D007422:Intestines / Q000276:immunology; D007616:Kaolin / Q000494:pharmacology*; D011514:Proteus vulgaris / Q000276:immunology; D011817:Rabbits; D013211:Staphylococcus aureus / Q000276:immunology; D015164:Vaccines, Inactivated / Q000276:immunology / Q000494:pharmacology*
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007136:Immunoglobulins; D015164:Vaccines, Inactivated; D002606:Charcoal; D007616:Kaolin