Antitumor activity of phytic acid (inositol hexaphosphate) in murine transplanted and metastatic fibrosarcoma, a pilot study.
We have previously reported that phytic acid (inositol hexaphosphate or InsP6), a natural constituent of cereal diet, when administered in drinking water exerts a consistent antitumor effect on experimental colon cancer in vivo. The objective of this study was to determine whether InsP6 has similar anti-neoplastic effect on other tumor models, such as murine fibrosarcoma. We report that intraperitoneal injection of InsP6 reduces growth of subcutaneously transplanted fibrosarcoma (FSA-1) in mice, prolongs survival of tumor-bearing mice and reduces the number of pulmonary metastases. Since InsP6 is a common constituent of our diet and has very little or no toxic effects, in addition to being chemopreventive, it could have potential use in therapy of cancer as well.
Vucenik
I
I
Department of Medical and Research Technology, University of Maryland School of Medicine, Baltimore 21201-1192.
Tomazic
V J
VJ
Fabian
D
D
Shamsuddin
A M
AM
D000818:Animals; D004357:Drug Synergism; D005354:Fibrosarcoma / Q000188:drug therapy* / Q000556:secondary*; D005856:Germ-Free Life; D007274:Injections, Intraperitoneal; D007294:Inositol / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D010833:Phytic Acid / Q000627:therapeutic use*; D010865:Pilot Projects
D007294:Inositol; D010833:Phytic Acid