Danazol therapy in idiopathic thrombocytopenic purpura: the efficacy of low-medium dose therapy.
To examine the effects and optimal dose of danazol on idiopathic thrombocytopenic purpura (ITP), we administered a low-medium dose to 14 patients with this disease. A low-medium dose of danazol was effective in maintaining the platelet count at a high level, even after the dose of prednisolone was reduced. A low-medium dose of danazol without other therapy was effective in 3 of 6 patients even after they had been refractory to other treatment. A low dose of danazol was also effective in some patients for whom the other regimes were not indicated. It is concluded that a low-medium dose of danazol instead of a high dose is worth trying in ITP when the patient has become refractory to other therapeutic approaches or when these are not indicated.
Kondo
H
H
Division of Internal Medicine, Shimizu Kousei Hospital, Shizuoka, Japan.
Iseki
T
T
Goto
S
S
Takaso
T
T
Ohto
M
M
Okuda
K
K
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000276:immunology; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000601:surgery / Q000628:therapy; D001792:Blood Platelets / Q000276:immunology; D003131:Combined Modality Therapy; D003613:Danazol / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007165:Immunosuppression Therapy; D008297:Male; D008875:Middle Aged; D010976:Platelet Count / Q000187:drug effects; D011239:Prednisolone / Q000627:therapeutic use; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy* / Q000601:surgery / Q000628:therapy; D013156:Splenectomy; D016896:Treatment Outcome
D001323:Autoantibodies; D007074:Immunoglobulin G; D011239:Prednisolone; D003613:Danazol