title: Pulmonary embolism in total hip and knee arthroplasty. Risk factors in patients on warfarin prophylaxis and analysis of the prothrombin time as an indicator of warfarin's prophylactic effect.
abstract: This study was designed to identify those total arthroplasty patients at high risk for embolism even while on a proven warfarin prophylactic regimen and to identify the measure of anticoagulation that would be most efficacious in the prevention of pulmonary embolism (PE). A series of 2348 total arthroplasty patients had a preoperative perfusion scan and a postoperative ventilation/perfusion scan. All patients were placed on a low-dose warfarin protocol. Eighty-one patients were identified as having a PE by pulmonary arteriography (incidence of 3.4%). Of these, 89% were asymptomatic and no case was fatal. A control group of 159 patients without PE was used for comparison. Patients older than 65 years of age with a history of genitourinary infection were identified as being at higher risk of PE while on a proven warfarin prophylactic program. These patients may need additional prophylactic measures to reduce the risk of PE. In contrast, patients with a history of phlebitis, PE, obesity, or varicosities were not at excess risk for PE while on warfarin prophylaxis; therefore, no additional prophylactic measures are required. All prothrombin time profiles were within the prophylactic range. Therefore, the actual prothrombin time may not be the critical determinant of the level of anticoagulation or prophylaxis achieved.
authors.affiliation: Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.
authors.forename: M J
authors.initials: MJ
authors.lastname: Lemos
authors.forename: D
authors.initials: D
authors.lastname: Sutton
authors.forename: W J
authors.initials: WJ
authors.lastname: Hozack
authors.forename: R A
authors.initials: RA
authors.lastname: Balderston
authors.forename: R E
authors.initials: RE
authors.lastname: Booth
authors.forename: R H
authors.initials: RH
authors.lastname: Rothman
mesh_terms: D000704:Analysis of Variance; D016009:Chi-Square Distribution; D006622:Hip Prosthesis / Q000009:adverse effects* / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D007720:Knee Prosthesis / Q000009:adverse effects* / Q000379:methods / Q000706:statistics & numerical data; D008168:Lung / Q000000981:diagnostic imaging; D011182:Postoperative Care; D011183:Postoperative Complications / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control; D016016:Proportional Hazards Models; D011517:Prothrombin Time; D011651:Pulmonary Artery / Q000000981:diagnostic imaging; D011655:Pulmonary Embolism / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control; D011859:Radiography; D011877:Radionuclide Imaging; D012307:Risk Factors; D014692:Ventilation-Perfusion Ratio; D014859:Warfarin / Q000008:administration & dosage*
chemical_list: D014859:Warfarin