Dipyridamole induced myocardial recovery after global ischemia.
1. An experimental comparative study on isolated guinea pig hearts was carried out to determine the effect of dipyridamole added to the reperfusion solution on myocardial recovery after global ischemia. 2. After 20 min of normothermic ischemia two groups of solutions: (1) Krebs solution; (2) Krebs + dipyridamole 20 micrograms/l (10 experiments in each group) were used for reperfusion. 3. Postischemic myocardial functions (heart rate, ventricular contractility, heart work) and tissue enzymes (CPK-MB, LDH) were compared with their preischemic values. 4. Addition of dipyridamole 20 micrograms/l to reperfusion solution improved postischemic myocardial functions and decreased myocardial injury.
Gökgöz
L
L
Department of Thoracic and Cardiovascular Surgery, Gazi University Medical School, Ankara, Turkey.
Soncul
H
H
Sinci
V
V
Karasu
C
C
Kaptanoglu
M
M
Yener
A
A
Ersöz
A
A
D000818:Animals; D003327:Coronary Disease / Q000201:enzymology / Q000503:physiopathology; D003402:Creatine Kinase / Q000378:metabolism; D004176:Dipyridamole / Q000494:pharmacology*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy / Q000503:physiopathology*; D009206:Myocardium / Q000201:enzymology
D004176:Dipyridamole; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase