title: [Evaluation of the incidence of nephrotoxicity associated with the use of aminoglycosides in patients with extrahepatic biliary obstruction].
abstract: In the present publication we discuss nephrotoxicity (NT) incidence by reviewing all the clinical histories of one year (May 1989-May 1990) with diagnosis of obstructive jaundice or cholangitis. Of a total of 90 patients. 53 were treated with aminoglycosides and 37 received other antibiotics. Nephrotoxicity developed in nine patients of the group that received aminoglycosides (17%), versus only three patients (8%) in the other group. Both groups were comparable regarding sex, age and liver and renal basal functions. Analysis of the variables that could be associated with a higher incidence in the nephrotoxicity group that received aminoglycosides showed that there were no differences regarding age, sex, dosage, duration of treatment, plasmatic levels of aminoglycosides and liver and renal basal functions. Only simultaneous administration o furosemide was significantly associated with the development of nephrotoxicity. Results of this study underline the need of a prospective follow-up of patients with biliary obstruction during treatment with aminoglycosides. Meanwhile the evidence available allows us to recommend the monitoring of renal function in this type of patients.
authors.affiliation: Servicio de Farmacología Clínica, Hospital Universitario, Facultad de Medicina, Málaga.
authors.forename: E
authors.initials: E
authors.lastname: Márquez
authors.forename: M I
authors.initials: MI
authors.lastname: Lucena
authors.forename: R J
authors.initials: RJ
authors.lastname: Andrade
authors.forename: J A
authors.initials: JA
authors.lastname: González-Correa
authors.forename: E
authors.initials: E
authors.lastname: Clavijo
authors.forename: M D
authors.initials: MD
authors.lastname: Lazo
authors.forename: F
authors.initials: F
authors.lastname: Sánchez de la Cuesta
mesh_terms: D000368:Aged; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001651:Cholestasis, Extrahepatic / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D007674:Kidney Diseases / Q000139:chemically induced*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents
vernacular_title: Evaluación de la incidencia de nefrotoxicidad asociada al uso de aminoglucósidos en pacientes con obstrucción biliar extrahepática.