The changes of peroxides and total antioxidants in the plasma of patients who received 131I therapeutically.
Fifty patients with thyroid cancer were studied during administration of high doses of 131I (5-50 mCi). Peroxides, total antioxidants and free sulphydryl-groups were measured in the blood samples obtained before and after administration of radioactive iodine. After the administration of iodine, significant increases of peroxides and free SH groups were observed, as well as the decrease of total antioxidants. These biochemical changes were in agreement with significant decreases of blood platelets and lymphocytes. The data obtained brought forward again the much debated problem of peroxidation and antioxidants in cancer, since comparatively, the patients with other localizations of tumors presented decreases of peroxides and variable amounts of antioxidants. The influence of iodine and thyroid hormones is discussed, with reference to a previous paper in which high levels of peroxides had been found both in hyper- and in hypothyroidism but with different mechanisms. The biochemical changes observed in the patients treated with radioactive iodine confirmed the involvement of peroxides in the consequences of internal irradiation.
Olinescu
R
R
Radiobiology Department, Fundeni Clinical Hospital, Bucharest, Romania.
Bartoc
R
R
Militaru
M
M
Niţă
S
S
Dimitriu
L
L
D000328:Adult; D000975:Antioxidants / Q000032:analysis*; D001772:Blood Cell Count / Q000528:radiation effects; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D010545:Peroxides / Q000097:blood*; D011879:Radiotherapy Dosage; D013964:Thyroid Neoplasms / Q000097:blood / Q000532:radiotherapy; D013972:Thyrotropin / Q000097:blood; D013997:Time Factors
D000975:Antioxidants; D007457:Iodine Radioisotopes; D010545:Peroxides; D013972:Thyrotropin