title: [Passive Ca2+ influx into vesicles of the sarcoplasmic reticulum, modified by succinic anhydride].
abstract: Treatment of the sarcoplasmic reticulum (SR) vesicles with succinic anhydride in concentration of 1-2 mM modifies about 20% of amino groups. It increases initial rate and changes the pH-dependence of the passive influx of Ca2+ into vesicles and does not affect either Ca(2+)-binding or maximal passive Ca(2+)-loading of the SR vesicles. It is supposed that this effect may be caused by modification of the Ca-channel gating behaviour as a result of replacement of positive surface amino groups by carboxyl groups.
authors.forename: V A
authors.initials: VA
authors.lastname: Tugay
authors.forename: G P
authors.initials: GP
authors.lastname: Diadiusha
authors.forename: V P
authors.initials: VP
authors.lastname: Zimina
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002413:Cations, Divalent; D006863:Hydrogen-Ion Concentration; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D011817:Rabbits; D012519:Sarcoplasmic Reticulum / Q000187:drug effects / Q000378:metabolism*; D013387:Succinic Anhydrides / Q000494:pharmacology*
chemical_list: D002413:Cations, Divalent; D013387:Succinic Anhydrides; C031801:succinic anhydride; D002118:Calcium
vernacular_title: Passivnyĭ vkhod Ca2+ v vezikuly sarkoplazmaticheskogo retikuluma, modifitsirovannye iantarnym angidridom.