Demonstration of ryanodine-induced metabolic effects in rat liver.
The effects of ryanodine, a plant alkaloid which alters Ca2+ sequestration in the liver, on O2 uptake and gluconeogenesis were measured. Ryanodine administration to perfused rat liver resulted in the stimulation of O2 uptake and of gluconeogenesis. Because ryanodine does not affect directly mitochondrial respiration, its stimulatory effect on O2 uptake in the whole cell is likely to be secondary to the increased cytosolic free Ca2+ levels.
Pereira
B
B
Department of Physiology and Cell Biology, University of Texas Medical School, Houston 77225.
Feng
L
L
Bazotte
R
R
Hernandez
L
L
Uribe
S
S
Kraus-Friedmann
N
N
D000818:Animals; D005943:Gluconeogenesis; D005947:Glucose / Q000032:analysis; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects; D010101:Oxygen Consumption; D051381:Rats; D011919:Rats, Inbred Strains; D012433:Ryanodine / Q000494:pharmacology*
D012433:Ryanodine; D005947:Glucose