title: Effects of chlorhexidine-containing gel and varnish on abutment teeth in patients with overdentures.
abstract: Previous experiments have shown that daily use of 1% chlorhexidine gel strongly reduced caries development in the abutment teeth under overdentures. The present experiment was designed to determine whether intermittent application of chlorhexidine, either in a varnish or in a gel, might be used as an alternative preventive method, less demanding for the patient. To this end, 31 patients were distributed among four treatment groups, with the number of mutans streptococci in plaque and saliva used as a balancing criterion. The treatments consisted of a single application of 40% chlorhexidine varnish, daily application of 1% chlorhexidine gel for one week, or the corresponding placebo treatments with varnish or gel without chlorhexidine. Patients were re-called for bacteriological and clinical examination at various intervals during an eight-week period following treatment. Chlorhexidine varnish and chlorhexidine gel applications significantly suppressed mutans streptococci on the abutment teeth for four and eight weeks, respectively. In agreement with earlier findings, the numbers of Actinomyces viscosus/naeslundii in plaque were significantly increased after chlorhexidine varnish treatment. The chlorhexidine gel reduced plaque accumulation and gingival bleeding for one week but had no long-lasting effect. The results seem to justify a long-term clinical test of intermittent chlorhexidine applications as an alternative for daily use in patients with overdentures.
authors.affiliation: Trikon, Institute for Dental Clinical Research, Dental School, University of Nijmegen, The Netherlands.
authors.forename: H M
authors.initials: HM
authors.lastname: Keltjens
authors.forename: T J
authors.initials: TJ
authors.lastname: Creugers
authors.forename: M J
authors.initials: MJ
authors.lastname: Schaeken
authors.forename: J S
authors.initials: JS
authors.lastname: Van der Hoeven
mesh_terms: D000704:Analysis of Variance; D002710:Chlorhexidine / Q000008:administration & dosage* / Q000494:pharmacology; D015169:Colony Count, Microbial; D000044:Dental Abutments; D003731:Dental Caries / Q000517:prevention & control*; D003773:Dental Plaque / Q000382:microbiology / Q000517:prevention & control*; D003774:Dental Plaque Index; D003828:Denture, Overlay; D005260:Female; D005782:Gels; D006801:Humans; D007764:Lacquer; D008297:Male; D012463:Saliva / Q000382:microbiology; D013295:Streptococcus mutans / Q000187:drug effects
chemical_list: D005782:Gels; D002710:Chlorhexidine