[Dynamics of disorders of cellular and humoral immunity parameters in patients with insulin-dependent diabetes mellitus].
Analysis of immunocompetent cell subsets in peripheral blood of patients with insulin dependent diabetes mellitus (IDDM) and the determination of sICA-autoantibodies in their sera were performed by flow rate cytometry and compared to healthy donors and patients with noninsulin-dependent diabetes mellitus (NIDDM). It was shown that newly diagnosed IDDM was characterized by predominant disturbances of humoral immunity, and disease progression was mainly accompanied by cellular immunity disturbances. Exogenous insulin was one of the causes of such disturbances. A tendency to normalization of cellular rather than humoral immunity was observed after the onset of human monocompetent therapy of IDDM patients. It is likely that the appearance in the peripheral blood of activated T-lymphocytes accompanied by sICA-autoantibodies and increased mature B-lymphocytes and NK-cells counts corresponds to increased ADCC against pancreatic beta cells in IDDM development.
Khaitov
R M
RM
Dedov
I I
II
Brykova
S V
SV
Smirnova
O M
OM
Esenin
V I
VI
Andreev
V N
VN
Nikonova
T V
TV
Kireeva
A P
AP
Gudima
G O
GO
Alekseev
L P
LP
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001323:Autoantibodies / Q000097:blood; D001402:B-Lymphocytes / Q000276:immunology; D002478:Cells, Cultured; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D003937:Diagnosis, Differential; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007328:Insulin / Q000627:therapeutic use; D007515:Islets of Langerhans / Q000276:immunology; D007958:Leukocyte Count / Q000187:drug effects; D008213:Lymphocyte Activation / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology
D001323:Autoantibodies; D007328:Insulin
Dinamika narusheniĭ pokazateleĭ kletochnogo i gumoral'nogo immuniteta u bol'nykh insulinzavisimym sakharnym diabetom.