Carbohydrate changes in bladder carcinomas.
The cloning of glycosyltransferases is a major breakthrough in the study of glycosylation in normal an malignant tissue. In bladder tumours we need a molecular explanation for the changes observed in especially Gal alpha 1-3 and GalNac alpha 1-3 transferase activity. Studies of the events (transcription/translation) taking place in the different cell layers would also be of importance, especially if the cells could be sorted layer by layer. The urine is a source of malignant cells, and could be a target for diagnosis as well as monitoring. Studies of urinary tumour-associated glycoconjugates or tumour-associated rearrangements in glycosyltransferase genes in exfoliated cells would be of great interest.
Orntoft
T F
TF
University Department of Clinical Chemistry, Aarhus Kommunehospital, Denmark.
D000017:ABO Blood-Group System / Q000737:chemistry / Q000378:metabolism; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000378:metabolism*; D002240:Carbohydrate Sequence; D002277:Carcinoma / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism; D004912:Erythrocytes / Q000276:immunology; D006001:Glycoconjugates / Q000378:metabolism*; D006801:Humans; D007983:Lewis Blood Group Antigens / Q000737:chemistry / Q000378:metabolism; D008969:Molecular Sequence Data; D012463:Saliva / Q000276:immunology; D001749:Urinary Bladder Neoplasms / Q000378:metabolism*; D014552:Urinary Tract Infections / Q000150:complications
D000017:ABO Blood-Group System; D015295:Antigens, Tumor-Associated, Carbohydrate; D006001:Glycoconjugates; D007983:Lewis Blood Group Antigens