title: Treatment with intravitreal steroid reduces blood-retinal barrier breakdown due to retinal photocoagulation.
abstract: The effect of corticosteroid treatment on blood-retinal barrier breakdown caused by argon-laser panretinal photocoagulation was evaluated in the rabbit eye. One day before photocoagulation, eyes were given either a sub-Tenon (20-mg) or intravitreal (2-mg) injection of triamcinolone acetonide. The severity of blood-retinal barrier breakdown was measured after photocoagulation using rapid sequential magnetic resonance imaging following intravenous administration of gadolinium diethylenetriaminepentaacetic acid. Leakage of gadolinium diethylenetriaminepentaacetic acid into the vitreous space was significantly lower in eyes that received intravitreal triamcinolone acetonide than in control eyes (P = .007); however, sub-Tenon triamcinolone acetonide produced no significant reduction in leakage (P = .65) compared with controls. Fluorescein angiography supported the magnetic resonance imaging findings. We conclude that retinal photocoagulation in the rabbit eye produces blood-retinal barrier breakdown that is partially amenable to corticosteroid treatment.
authors.affiliation: Department of Ophthalmology, Duke University Medical Center, Durham, NC 27710.
authors.forename: C A
authors.initials: CA
authors.lastname: Wilson
authors.forename: B A
authors.initials: BA
authors.lastname: Berkowitz
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: N
authors.initials: N
authors.lastname: Ando
authors.forename: J T
authors.initials: JT
authors.lastname: Handa
authors.forename: E
authors.initials: E
authors.lastname: de Juan
mesh_terms: D000818:Animals; D001813:Blood-Retinal Barrier / Q000187:drug effects*; D003287:Contrast Media; D005451:Fluorescein Angiography; D019786:Gadolinium DTPA; D007267:Injections; D053685:Laser Therapy; D008028:Light Coagulation; D008279:Magnetic Resonance Imaging; D009942:Organometallic Compounds; D004369:Pentetic Acid; D011817:Rabbits; D012160:Retina / Q000473:pathology / Q000601:surgery*; D014222:Triamcinolone Acetonide / Q000008:administration & dosage* / Q000494:pharmacology; D014822:Vitreous Body
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D014222:Triamcinolone Acetonide; D019786:Gadolinium DTPA