title: Regulation of biosynthesis of vermiculin and vermistatin in Penicillium vermiculatum.
abstract: Biosynthesis of vermiculin (1) and vermistatin (2) in Penicillium vermiculatum can be controlled by the carbon and nitrogen sources. Glucose and sucrose affect the levels of the two metabolites; cornsteep liquor influences the quality the biosynthesis. The concentrations of Fe3+ and Cu2+ ions also affect the biosynthesis, the effect being dependent on the type of carbon source utilized. The compounds capable of electron transport generally stimulate the production of 1 and 2 but do not influence the biosynthesis qualitatively.
authors.affiliation: Department of Biochemical Technology, Faculty of Chemical Technology, Slovak Technical University, Bratislava.
authors.forename: J
authors.initials: J
authors.lastname: Adamcová
authors.forename: B
authors.initials: B
authors.lastname: Proksa
authors.forename: J
authors.initials: J
authors.lastname: Fuska
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D002244:Carbon / Q000502:physiology; D003300:Copper / Q000502:physiology; D003470:Culture Media; D007501:Iron / Q000502:physiology; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D007783:Lactones / Q000378:metabolism; D009584:Nitrogen / Q000502:physiology; D010407:Penicillium / Q000378:metabolism*; D011753:Pyrones / Q000378:metabolism*
chemical_list: D000903:Antibiotics, Antineoplastic; D003470:Culture Media; D007773:Lactates; D007783:Lactones; D011753:Pyrones; D019344:Lactic Acid; C009650:vermiculine; C051060:vermistatin; D002244:Carbon; D003300:Copper; D007501:Iron; D009584:Nitrogen