title: Histiocytic lymphophagocytic panniculitis (Rosai-Dorfman disease): a case report.
abstract: A 68-year-old woman presented with a symmetrical enlargement of the face and submandibular area associated with essential thrombocytosis. Biopsy of the lesions revealed a septal and lobular panniculitis disclosing a lymphohistiocytic and plasma cell proliferation with lymphophagocytosis by histiocytes, compatible with Rosai-Dorfman disease. The lesions regressed spontaneously without therapy over a period of 4 months. Diagnosis was confirmed by electron-microscopic examination and immunocytochemical presence of S-100 antigen within the histiocytic cells. A 2-year follow-up did not demonstrate any evidence of recurrence.
authors.affiliation: Clinique de Dermatologie, Hôpital Cantonal Universitaire de Genève, Suisse.
authors.forename: D
authors.initials: D
authors.lastname: Puppin
authors.forename: P
authors.initials: P
authors.lastname: Chavaz
authors.forename: M
authors.initials: M
authors.lastname: Harms
mesh_terms: D000368:Aged; D005260:Female; D015618:Histiocytosis, Sinus / Q000150:complications / Q000473:pathology*; D006801:Humans; D008297:Male; D015434:Panniculitis / Q000150:complications / Q000473:pathology*; D013922:Thrombocytosis / Q000150:complications / Q000473:pathology*