Cefetamet pivoxil in pediatric otitis media.
Cefetamet, an oral 3rd-generation cephalosporin, was investigated in 40 children with acute otitis media in a comparative randomized trial. The efficacy of 20 mg/kg cefetamet syrup in 20 patients was compared with that of 20 mg/kg cefaclor in another 20, both drugs being given orally twice daily for 7 days. Tympanocentesis was performed for every child before the initiation of antimicrobial treatment. After 7 days treatment with cefetamet pivoxil, clinical cure was obtained in 12 patients, 3 were failures and 5 could not be assessed. In the cefaclor group, 10 patients were cured, 1 improved and 9 were failures. No severe adverse events were observed with either drug.
Pukander
J S
JS
Department of Otolaryngology, University Hospital of Tampere, Finland.
Paloheimo
S H
SH
Sipilä
M M
MM
D000208:Acute Disease; D000284:Administration, Oral; D001424:Bacterial Infections / Q000188:drug therapy*; D002433:Cefaclor / Q000008:administration & dosage / Q000627:therapeutic use; D015296:Ceftizoxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D010033:Otitis Media / Q000188:drug therapy*; D016896:Treatment Outcome
D002433:Cefaclor; D015296:Ceftizoxime; C047445:cefetamet pivoxyl