title: Further evidence for differential regulation of follicle-stimulating hormone (FSH) and luteinizing hormone (LH): increased FSH and decreased LH levels in a patient with familial pure gonadal dysgenesis.
abstract: There is experimental evidence that a portion of follicle-stimulating hormone (FSH) secretion is independent of hypothalamic influences. A 29 year old woman with familial pure gonadal dysgenesis developed myelodysplastic syndrome. Endocrine investigations showed discrepancy between serum FSH and luteinizing hormone (LH) levels. FSH levels remained elevated while LH levels decreased. The FSH to LH ratio was 10 (normal 2-2.5). The fall in LH is likely to be due to factor(s) involved directly and specifically in LH synthesis and release. Exogenous LH releasing hormone administration as well as hormonal replacement treatment increased LH levels. The FSH to LH ratio decreased to 7. This case supports the hypothesis of differential regulation of FSH and LH, and that FSH secretion is at least partly autonomous.
authors.affiliation: Institute of Endocrinology, University Clinical Center, School of Medicine, Belgrade, Yugoslavia.
authors.forename: V
authors.initials: V
authors.lastname: Popovic
authors.forename: D
authors.initials: D
authors.lastname: Micic
authors.forename: S
authors.initials: S
authors.lastname: Damjanovic
authors.forename: L
authors.initials: L
authors.lastname: Calovic
authors.forename: Z
authors.initials: Z
authors.lastname: Rolovic
authors.forename: A
authors.initials: A
authors.lastname: Mijovic
authors.forename: M
authors.initials: M
authors.lastname: Petakov
authors.forename: D
authors.initials: D
authors.lastname: Manojlovic
authors.forename: J
authors.initials: J
authors.lastname: Micic
mesh_terms: D000328:Adult; D000754:Anemia, Refractory, with Excess of Blasts / Q000097:blood; D015914:Estrogen Replacement Therapy; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006059:Gonadal Dysgenesis / Q000097:blood* / Q000235:genetics; D012739:Gonadal Steroid Hormones / Q000097:blood; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*
chemical_list: D012739:Gonadal Steroid Hormones; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone