Historic reflection on steroids: Lederle and personal aspects.
Steroid research at Lederle was initiated in 1946 and continued until about 1971. The areas of research interest involved primarily a study of delta 5,7-steroids, provitamin D3 variants, dehydroepiandrosterone variants, steroidal ketals, corticoids, and steroid conjugates. One of the principal goals was to develop novel antiinflammatory steroids for the treatment of, e.g., rheumatoid arthritis. A rational design led to the development of 16 alpha-hydroxycorticoids, culminating in the synthesis and therapeutic use of triamcinolone and related compounds.
Bernstein
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Medical Research Division, Lederle Laboratories, American Cyanamid Company, Pearl River, New York.
D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry; D004345:Drug Industry / Q000266:history*; D049673:History, 20th Century; D013256:Steroids / Q000737:chemistry* / Q000266:history; D013678:Technology, Pharmaceutical / Q000266:history*; D014481:United States
D000893:Anti-Inflammatory Agents; D013256:Steroids