Molecular targets to overcome radioresistance.
Our laboratory has cultured cells from 23 patients with head and neck carcinoma and 13 patients with soft tissue sarcoma. The data suggest that, in some patients, inherent tumor cell radioresistance contributes to radiotherapy failure. This paper examines possible mechanisms that lead to increased cell survival following radiation exposure, and their potential as targets to overcome the radioresistant patient population.
Weichselbaum
R R
RR
Department of Radiation and Cellular Oncology, University of Chicago Hospitals, IL 60637.
Beckett
M A
MA
Hallahan
D E
DE
Kufe
D W
DW
Vokes
E E
EE
D000970:Antineoplastic Agents / Q000494:pharmacology; D002470:Cell Survival / Q000528:radiation effects; D016207:Cytokines / Q000096:biosynthesis; D004260:DNA Repair; D005786:Gene Expression Regulation; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*; D009857:Oncogenes; D011836:Radiation Tolerance; D015398:Signal Transduction; D014407:Tumor Cells, Cultured / Q000528:radiation effects
D000970:Antineoplastic Agents; D016207:Cytokines