The MHC: relationship between linkage and function.
It is intriguing that several genes with associated functions, including all of class I and class II genes, as well as some genes affecting antigen presentation of both class I and class II pathways, are linked in the MHC. Recent observations have led to speculation that there may be a functional explanation for keeping these related genes together.
Trowsdale
J
J
Human Immunogenetics Laboratory, Imperial Cancer Research Fund, Hoborn, London, UK.
Powis
S H
SH
D000818:Animals; D000941:Antigens / Q000378:metabolism; D030342:Genetic Diseases, Inborn; D008040:Genetic Linkage; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics*
D000941:Antigens