GABAergic and cholinergic mediation in the antinociceptive action of homotaurine.
1. The role of GABAergic and cholinergic mechanisms in the antinociceptive effect of homotaurine (22.25-111.24 mg/kg i.p.) in chemical (acetic acid) and thermal (tail flick, tail immersion) tests has been studied by means of the interaction with baclofen and anticholinergic drugs. 2. Baclofen (2 mg/kg p.o.) and scopolamine sulfate (2.5 mg/kg i.p.) potentiate the antinociceptive effect of the amino acid in the chemical test. 3. Bicuculline (1 mg/kg i.p.) pretreatment does not modify the antinociceptive effect of homotaurine in the tail immersion and tail flick tests. 4. Scopolamine sulfate and methylnitrate (1 mg/kg i.p.) antagonise the effect of homotaurine (111.24 mg/kg i.p.) in the tail flick test. 5. The above results imply that peripheral GABAB and central cholinergic mechanisms play a role in the antinociceptive effect of homotaurine.
Serrano
I
I
Department of Pharmacology, Pediatrics and Radiology, Medical School, Sevilla University, Spain.
Ruiz
R M
RM
Serrano
J S
JS
Fernández
A
A
D000085:Acetates; D019342:Acetic Acid; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D007101:Immersion / Q000503:physiopathology; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control; D010147:Pain Measurement; D010275:Parasympathetic Nervous System / Q000502:physiology*; D011930:Reaction Time / Q000187:drug effects; D012601:Scopolamine / Q000494:pharmacology; D013654:Taurine / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D000085:Acetates; D000700:Analgesics; D013654:Taurine; D005680:gamma-Aminobutyric Acid; C001355:tramiprosate; D012601:Scopolamine; D001418:Baclofen; D019342:Acetic Acid