Hereditary ovarian carcinoma.
No woman is at greater risk for ovarian carcinoma than one who is a member of a hereditary ovarian carcinoma syndrome kindred and whose mother, sister, or daughter has been affected with this disease and with an integrally related hereditary syndrome cancer. This article surveys the existing understanding about hereditary ovarian carcinoma. Emphasis is given to its diagnosis, heterogeneity, interpretation, and the application of this information to improving cancer control.
Lynch
H T
HT
Department of Preventive Medicine/Public Health, Creighton University School of Medicine, Omaha, Nebraska.
Lynch
J F
JF
D004198:Disease Susceptibility; D005260:Female; D005817:Genetic Counseling; D006801:Humans; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics; D010051:Ovarian Neoplasms / Q000235:genetics*; D010375:Pedigree; D012307:Risk Factors