[C-peptide and insulin ratio in patients with juvenile dyspituitarism in varying symptomatology].
Altogether 24 adolescents with pubertal juvenile dyspituitarism (PJD) were investigated in the course of an oral GTT for 3 hours. The patients were divided into 3 groups: (1) with liver dysfunction and normal BP; (2) with normal liver and arterial hypertension; (3) with normal BP and normal liver function. The levels of glycemia, immunoreactive insulin, C-peptide and a molar C-peptide/insulin ratio were measured. All the examinees were characterized by basal and stimulated hyperinsulinemia against a background of a normal C-peptide value, the absence of a tendency to IRI reduction by the end of the GTT. A decrease in the C-peptide/IRI ratio was marked in the 1st group. One of the reasons of hyperinsulinemia in PJD in parallel with high insulin secretory pancreatic function can be a decrease in the metabolic clearance of liver insulin, especially noticeable in patients with hepatocyte dysfunction.
Malygina
E V
EV
Belovalova
I M
IM
Starkova
N T
NT
Starosel'tseva
L K
LK
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D002096:C-Peptide / Q000097:blood*; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension / Q000097:blood; D007328:Insulin / Q000097:blood* / Q000493:pharmacokinetics; D008107:Liver Diseases / Q000097:blood; D008657:Metabolic Clearance Rate / Q000502:physiology; D010900:Pituitary Diseases / Q000097:blood*; D012016:Reference Values
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin
Sootnoshenie C-peptida i insulina u bol'nykh s iunosheskim dispituitarizmom pri razlichnoĭ klinicheskoĭ simptomatike.