title: Joint effect of gestational age and maternal lead exposure on psychomotor development of the child at six years.
abstract: A prospective study has been carried out to assess the psychomotor deficit resulting from a moderate decrease in gestational age and pre-natal lead exposure. The general cognitive index of the McCarthy psychometric scale (adjusted for confounders) in six-year-old children was related to gestational age. Most of the psychomotor scores showed smoothing variations with gestational age ranging from 37 to 39 weeks, whereas sharp changes occurred between 39 to 40 weeks, with plateau values above such a cut-off for all spheres of development examined. Maternal hair lead content, used as an indicator of lead exposure during pregnancy, was found to be negatively related to general cognitive, verbal, quantitative, and memory subscales (p less than 0.01), whereas its relationship with perceptual and motor subscales was close to 0.05 significance level. Control for gestational age did not change the significance level of the associations. When controlling for maternal hair lead levels, the significance of the association between gestational age and the McCarthy subscales also remained stable, only the general cognitive index and verbal subscale reaching the conventional significance level.
authors.affiliation: Epidemiological Research Unit (U169), INSERM, Villejuif, France.
authors.forename: G
authors.initials: G
authors.lastname: Huel
authors.forename: P
authors.initials: P
authors.lastname: Tubert
authors.forename: N
authors.initials: N
authors.lastname: Frery
authors.forename: T
authors.initials: T
authors.lastname: Moreau
authors.forename: J
authors.initials: J
authors.lastname: Dreyfus
mesh_terms: D002648:Child; D015986:Confounding Factors, Epidemiologic; D005260:Female; D005865:Gestational Age; D006197:Hair / Q000737:chemistry; D006801:Humans; D007854:Lead / Q000032:analysis; D007855:Lead Poisoning / Q000523:psychology*; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011446:Prospective Studies; D011597:Psychomotor Performance / Q000187:drug effects*
chemical_list: D007854:Lead