Involvement of hypothalamic noradrenergic systems in the modulation of intestinal motility in rats.
Selective lesions of the noradrenergic systems of the paraventricular nucleus (PVN) of the hypothalamus with 6-hydroxydopamine (6-OHDA) lengthen the periodicity of the migrating myoelectric complex (MMC), an index of intestinal motility, in rats. These lengthening effects resemble those obtained after lesions of the locus coeruleus (LC), thus suggesting that noradrenergic terminals from LC to the PVN are involved in this modulation.
Bonaz
B
B
Laboratoire de Physiologie, Institut National de la Santé et de la Recherche Médicale, U318, Grenoble, France.
Martin
L
L
Beurriand
E
E
Hostein
J
J
Feuerstein
C
C
D000704:Analysis of Variance; D000818:Animals; D004298:Dopamine / Q000378:metabolism / Q000502:physiology*; D004837:Epinephrine / Q000378:metabolism / Q000502:physiology*; D005769:Gastrointestinal Motility; D008125:Locus Coeruleus / Q000502:physiology; D008297:Male; D016065:Myoelectric Complex, Migrating / Q000502:physiology*; D009638:Norepinephrine / Q000378:metabolism / Q000502:physiology*; D016627:Oxidopamine / Q000633:toxicity; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D016627:Oxidopamine; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine