title: [A biochemical study of an animal model with defective muscle glycolysis, induced by iodoacetate administration].
abstract: A rat model produced by intraaortic injection of sodium iodoacetate was analyzed biochemically. Hind leg muscles obtained from iodoacetate-injected site showed a selective inhibition of the glyceraldehyde-3-phosphate dehydrogenase (G3PD) activity less than 10% of control mean. No loss of mitochondrial enzyme activity was observed. Electrical stimulation at the sciatic nerve revealed muscle contractures and this muscle showed a mild degeneration in histochemically. This study indicates that this model will be useful to study the pathophysiology of human muscle glycogen storage diseases.
authors.affiliation: Department of Pediatrics, Hamamatsu University School of Medicine, Shizuoka.
authors.forename: N
authors.initials: N
authors.lastname: Furukawa
authors.forename: H
authors.initials: H
authors.lastname: Sugie
authors.forename: S
authors.initials: S
authors.lastname: Tsurui
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: Y
authors.initials: Y
authors.lastname: Igarashi
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000378:metabolism*; D006008:Glycogen Storage Disease / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D007461:Iodoacetates; D019807:Iodoacetic Acid; D009132:Muscles / Q000201:enzymology / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007461:Iodoacetates; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D019807:Iodoacetic Acid