[Correlation between risk profile and severity and age at manifestation of coronary heart disease--findings in 3,715 patients].
In 3715 survivors (pts) of an acute myocardial infarction (3343 males and 372 females), of ages between 20 and 80 years (mean 52.9 +/- 7.7 years), lipid-metabolism, amount of cigarette-smoking, severity of coronary artery disease (CHD) by selective coronary arteriography, and age at first manifestation of CHD documented by myocardial infarction were investigated. In contrast to normals, there is a significant reduction of disorders of lipid-metabolism with increasing age. The rate of cigarette-smoking is lower in the elderly. Females are affected by MI 3.6 to 5.3 years later than are males. There was a strong correlation between the degree of lipid-disorders and the severity of CHD, whereas the lipid-disturbances were mostly marked in the younger pts. Dependent on the degree of the underlying lipid-disorder, CHD strikes pts at a younger age, whereby the Chol/HDL-Chol-ratio is most sensitive. In a similar manner, cigarette-smoking transfers the manifestation-date of CHD "dose-dependent" to a younger age. Smokers with a daily consumption of more than 40 cigarettes are 9.2 years younger at the time of first myocardial infarction than are non-smokers. In older pts the influence of lipid-disorders and smoking becomes smaller, compared with the risk-factor "age", but it is also significant. The proven correlation between the risk-profile and the age at first myocardial event stresses the need for preventive and educative strategies.
Köhler
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Salzetalklinik, Landesverischerungsanstalt Westfalen in Bad Salzuflen.
Fenzl
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R
Schönfeld
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R
Tataru
M C
MC
D000328:Adult; D000367:Age Factors; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000503:physiopathology* / Q000534:rehabilitation; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology* / Q000534:rehabilitation; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol
Untersuchungen über den Zusammenhang zwischen dem Risikoprofil und dem Schweregrad bzw. dem Manifestationsalter der koronaren Herzkrankheit (KHK)--Befunde von 3715 Patienten.