title: Giant negative U waves in a patient with uncontrolled hypertension and severe hypokalemia.
abstract: A 66-year-old woman with a long history of hypertension had an electrocardiogram with giant negative U waves in left precordial leads despite hypokalemia. This seems to be the first report of giant negative U waves induced by uncontrolled hypertension with hypokalemia. The occurrence of negative U waves in the presence of profound hypokalemia is an important observation because it masks the electrocardiographic manifestation of hypokalemia.
authors.affiliation: Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Kanemoto
authors.forename: K
authors.initials: K
authors.lastname: Nakayama
authors.forename: M
authors.initials: M
authors.lastname: Ide
authors.forename: Y
authors.initials: Y
authors.lastname: Goto
mesh_terms: D000368:Aged; D002908:Chronic Disease; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D005260:Female; D005440:Fluid Therapy; D005756:Gastritis / Q000150:complications / Q000188:drug therapy; D006034:Glycyrrhetinic Acid / Q000009:adverse effects / Q000031:analogs & derivatives; D006035:Glycyrrhiza; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D007008:Hypokalemia / Q000139:chemically induced / Q000175:diagnosis* / Q000628:therapy; D009529:Nicardipine / Q000627:therapeutic use; D010936:Plant Extracts / Q000009:adverse effects; D010946:Plants, Medicinal; D012824:Silicic Acid / Q000009:adverse effects; D013148:Spironolactone / Q000008:administration & dosage; D014636:Valsalva Maneuver
chemical_list: D010936:Plant Extracts; C076590:licorice extract - magnesium aluminometasilicate; D012824:Silicic Acid; D013148:Spironolactone; D009529:Nicardipine; D006034:Glycyrrhetinic Acid