title: Conformational feature of neuroactive domoic acid: X-ray structural comparison with isodomoic acid A and alpha-kainic acid.
abstract: As an aid for developing a new type of potent insecticide acting on the neuromuscular junction, conformational characteristics of domoic acid and isodomoic acid A, the naturally occurring glutamate agonists, were investigated by X-ray crystal analyses. Conformational comparison with a neuroactive alpha-kainic acid provides information concerning the stereochemical feature responsible for the biological activity.
authors.affiliation: Suntory Institute for Bioorganic Research, Osaka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nomoto
authors.forename: T
authors.initials: T
authors.lastname: Takemoto
authors.forename: M
authors.initials: M
authors.lastname: Maeda
authors.forename: Y
authors.initials: Y
authors.lastname: In
authors.forename: M
authors.initials: M
authors.lastname: Doi
authors.forename: M
authors.initials: M
authors.lastname: Inoue
authors.forename: T
authors.initials: T
authors.lastname: Ishida
mesh_terms: D007306:Insecticides / Q000737:chemistry*; D007608:Kainic Acid / Q000031:analogs & derivatives* / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D014961:X-Ray Diffraction
chemical_list: D007306:Insecticides; C012301:domoic acid; D007608:Kainic Acid