Prosthetic hip-joint infection associated with a penicillin-tolerant group B streptococcus.
We report a case of prosthetic hip-joint infection with Streptococcus agalactiae (Lancefield group B streptococcus). The infection recurred after 3 months' treatment with amoxycillin. On further investigation, the isolate was found to be amoxycillin-tolerant. Addition of gentamicin abolished tolerance in vitro and the patient has remained asymptomatic since receiving a 10-day course of amoxycillin and gentamicin followed by amoxycillin alone.
Cunningham
R
R
Department of Medical Microbiology, Royal Liverpool University Hospital, U.K.
Walker
C
C
Ridgway
E
E
D000368:Aged; D000658:Amoxicillin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004361:Drug Tolerance; D005839:Gentamicins / Q000627:therapeutic use*; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D016459:Prosthesis-Related Infections / Q000188:drug therapy / Q000382:microbiology*; D013290:Streptococcal Infections / Q000188:drug therapy / Q000382:microbiology*; D013292:Streptococcus agalactiae; D006113:United Kingdom
D005839:Gentamicins; D000658:Amoxicillin