[Clinico-morphological characteristics of intrahepatic cholestasis in hepatitis A and delta infection].
Clinical and morphological characteristics were studied for a course of acute viral hepatitis A and delta with long-term cholestatic syndrome in asymptomatic carriers of HBsAg. 149 patients with moderate disease were examined, 53 of them had long-standing cholestasis syndrome. 96 viral hepatitis patients free of cholestasis served control. It is believed that the emergence of long-term intrahepatic cholestasis may be due to the following mechanisms of sinusoid lumina as a result of a drastic enlargement of multinuclear hepatocytes, hyperplasia and hypertrophy of Kupffer's cells. impaired binding of bilirubin in zone III of hepatic acinus. In cholestatic form of hepatitis A there occurs more pronounced reduction of sinusoid volume compared to other variants of viral hepatitis run.
Nikiforov
N D
ND
Trofimova
M N
MN
Il'inskiĭ
Iu A
IuA
Mamontov
S G
SG
Ivannikov
E V
EV
D002780:Cholestasis, Intrahepatic / Q000209:etiology / Q000473:pathology*; D006506:Hepatitis A / Q000150:complications* / Q000473:pathology; D003699:Hepatitis D / Q000150:complications* / Q000473:pathology; D006801:Humans; D006965:Hyperplasia / Q000150:complications; D006984:Hypertrophy / Q000150:complications; D007728:Kupffer Cells / Q000473:pathology; D008099:Liver / Q000473:pathology*
Kliniko-morfologicheskie osobennosti vnutripechenochnogo cholestaza pri virusnykh gepatitakh A i del'ta.