title: HLA-associations in Leponex/Clozaril (clozapine)-induced granulocytopenia and agranulocytosis. Statistical viewpoints.
abstract: This paper describes a statistical analysis of the simultaneous occurrence of 48 human leucocyte antigens (HLAs) in an attempt to predict whether a patient treated with clozapine will develop granulocytopenia or agranulocytosis. Whereas the numerical results show that use of HLAs does not appear to satisfy the intended purpose, emphasis is placed on the statistical methodology recommended for a problem of this type. Other work in this area is critically discussed.
authors.affiliation: Department of Biomathematics, University of Frankfurt, Federal Republic of Germany.
authors.forename: K
authors.initials: K
authors.lastname: Abt
authors.forename: A
authors.initials: A
authors.lastname: Gülich
authors.forename: P
authors.initials: P
authors.lastname: Krupp
authors.forename: W
authors.initials: W
authors.lastname: Reinberg
mesh_terms: D000380:Agranulocytosis / Q000139:chemically induced* / Q000276:immunology; D003024:Clozapine / Q000009:adverse effects*; D016002:Discriminant Analysis; D006680:HLA Antigens / Q000097:blood*; D006801:Humans
chemical_list: D006680:HLA Antigens; D003024:Clozapine