title: Mammalian artificial chromosomes.
abstract: A mammalian artificial chromosome would enable analysis of the cis-acting DNA sequences necessary for mammalian chromosome function and would allow large numbers of genes in a defined sequence environment to be introduced into experimental animals, agricultural livestock or human cells. Recent technical progress suggests that a route to mammalian artificial chromosome construction is now open.
authors.affiliation: Biochemistry Department, Oxford University, UK.
authors.forename: W R
authors.initials: WR
authors.lastname: Brown
mesh_terms: D000818:Animals; D002503:Centromere / Q000502:physiology; D002875:Chromosomes / Q000502:physiology*; D015825:Chromosomes, Fungal; D005813:Genes, Synthetic / Q000502:physiology*; D006801:Humans; D008322:Mammals; D016615:Telomere / Q000502:physiology