title: [Mode of action of non-narcotic analgesics].
abstract: According to Lim's experiments, non-narcotic analgesics are usually considered as "peripherally" acting drugs. Conversely, most of these compounds were shown to easily cross the blood-brain barrier, and hence partly produce their effects by a central mechanism. The relative contribution of each site of action may vary from one drug to another. Aspirin-like drugs may act by inhibiting arachidonate cyclooxygenase in both the damaged tissues and the central nervous system. Finally, these drugs appear to be either selective, or dose-dependent, or nonspecific inhibitors of prostaglandin-synthetases.
authors.affiliation: Centre de Pharmacologie, CHR Pellegrin, Bordeaux.
authors.forename: B
authors.initials: B
authors.lastname: Bannwarth
authors.forename: A
authors.initials: A
authors.lastname: Chaslerie
authors.forename: T
authors.initials: T
authors.lastname: Schaeverbeke
authors.forename: G
authors.initials: G
authors.lastname: Vinçon
authors.forename: J
authors.initials: J
authors.lastname: Dehais
authors.forename: B
authors.initials: B
authors.lastname: Begaud
mesh_terms: D000700:Analgesics / Q000145:classification / Q000494:pharmacology*; D000818:Animals; D006801:Humans; D011453:Prostaglandins / Q000096:biosynthesis
chemical_list: D000700:Analgesics; D011453:Prostaglandins
vernacular_title: Modes d'action des antalgiques non morphiniques.