[Eremomycin in the treatment of antibiotic-associated colitis in golden hamsters].
The efficacy of eremomycin, a new glycopeptide antibiotic, was studied on a model of antibiotic-associated colitis in golden hamsters. The colitis was induced by intraperitoneal or intragastric administration of lincomycin. In a dose of 100 mg/kg administered orally once a day for 5 days eremomycin protected the animals from the lincomycin-induced colitis: some animals survived, the others died in later periods. When the animals were infected with a pathogenetic strain of Clostridium difficile followed by exposure to lincomycin the use of eremomycin produced the similar effect.
Rukhlina
A A
AA
Malkova
L A
LA
Shevniuk
L A
LA
Fomina
T V
TV
Bukhman
V M
VM
Koroleva
V M
VM
Bakulin
I N
IN
Sergeeva
T I
TI
D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016360:Clostridioides difficile / Q000187:drug effects / Q000472:pathogenicity*; D006224:Cricetinae; D004195:Disease Models, Animal; D004761:Enterocolitis, Pseudomembranous / Q000139:chemically induced / Q000188:drug therapy* / Q000382:microbiology; D006020:Glycopeptides / Q000627:therapeutic use; D007274:Injections, Intraperitoneal; D008034:Lincomycin / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008647:Mesocricetus; D013997:Time Factors
D000900:Anti-Bacterial Agents; D006020:Glycopeptides; C053759:eremomycin; D008034:Lincomycin
Lechenie éremomitsinom antibiotikoassotsiirovannogo kolita zolotistykh khomiachkov.