title: Probing the molecular basis of resistance to pyrimethamine by site-directed mutagenesis.
authors.affiliation: Department of Chemistry, Pennsylvania State University, University Park 16802.
authors.forename: C R
authors.initials: CR
authors.lastname: Wagner
authors.forename: S J
authors.initials: SJ
authors.lastname: Benkovic
mesh_terms: D000818:Animals; D001665:Binding Sites; D004351:Drug Resistance / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology / Q000235:genetics; D005493:Folic Acid Antagonists; D007700:Kinetics; D016297:Mutagenesis, Site-Directed; D010961:Plasmodium / Q000187:drug effects / Q000201:enzymology / Q000235:genetics; D011739:Pyrimethamine / Q000494:pharmacology*; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics*; D013816:Thermodynamics
chemical_list: D005493:Folic Acid Antagonists; D013762:Tetrahydrofolate Dehydrogenase; D011739:Pyrimethamine