title: Simulation of compartmental models for kinetic data from a positron emission tomograph.
abstract: Linear compartmental models are used to describe the disposition of radio-labelled compounds in regions of interest in the mammalian body, based on a time sequence of measurements from a positron emission tomograph (PET). In this paper we show how closed form solutions for the model equations have been incorporated into a computer program for simulation and parameter estimation. A typical PET data example is included to illustrate the implementation and compare the closed form method with a numerical ode solution method.
authors.affiliation: Center for Functional Imaging, Lawrence Berkeley Lab, CA 94720.
authors.forename: P G
authors.initials: PG
authors.lastname: Coxson
authors.forename: E M
authors.initials: EM
authors.lastname: Salmeron
authors.forename: R H
authors.initials: RH
authors.lastname: Huesman
authors.forename: B M
authors.initials: BM
authors.lastname: Mazoyer
mesh_terms: D001825:Body Fluid Compartments / Q000502:physiology*; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D003198:Computer Simulation; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008954:Models, Biological; D014055:Tomography, Emission-Computed
chemical_list: D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose