Herboxidiene, a new herbicidal substance from Streptomyces chromofuscus A7847. Taxonomy, fermentation, isolation, physico-chemical and biological properties.
Screening of microbial fermentation broths for herbicidal activity led to the discovery of a novel polyketide, herboxidiene, from an actinomycete identified as a member of the Streptomyces chromofuscus cluster. A 14- to 20-fold increase in fermentation production of herboxidiene was achieved as a result of media optimization. Herboxidiene was purified using successive reverse phase C18 steps and Sephadex LH-20 chromatography. Its molecular formula, C25H42O6, was determined by HRFAB-MS. Herboxidiene demonstrated exceptionally potent, selective, herbicidal activity against a variety of weed species and was inactive against wheat, even at rates as high as 5.6 kg/hectare.
Miller-Wideman
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M
Monsanto Agricultural Company, Monsanto Company, Chesterfield, Missouri 63198.
Makkar
N
N
Tran
M
M
Isaac
B
B
Biest
N
N
Stonard
R
R
D003470:Culture Media; D005233:Fatty Alcohols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D006540:Herbicides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000145:classification / Q000378:metabolism
D003470:Culture Media; D005233:Fatty Alcohols; D006540:Herbicides; D011714:Pyrans; C076087:herboxidiene