Valproate treatment of mania.
1. Acute as well as prophylactic effects of the anticonvulsant valproate are described in patients with mania and bipolar affective psychoses. 2. In a long-term evaluation of valproate prophylaxis ranging up to 14 years, an average improvement of the phase chart of 12 patients was observed by a factor of 12. 3. The mode of action of this effect appears to be related to the GABAergic properties of the compound.
Emrich
H M
HM
Max Planck Institute of Psychiatry, Munich, Germany.
Wolf
R
R
D000328:Adult; D000368:Aged; D000818:Animals; D001714:Bipolar Disorder / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D051381:Rats; D014635:Valproic Acid / Q000378:metabolism / Q000627:therapeutic use*
D014635:Valproic Acid