title: [Physical modeling of inhalation anesthesia].
abstract: A new physical model simulating the pharmacokinetics of volatile anaesthetics is presented. It consists in a ventilator connected to a water manometer. Gas is removed from the gaseous part of this manometer with a constant rate pump. This gas flow is directed thereafter into three capacitances with valves and pumps: one capacitance only contains air, representing the lungs, and the other two olive oil, representing the visceral and muscle compartments. Halothane, enflurane and isoflurane (1 vol%) were administered to this model with different values of cardiac output and alveolar ventilation. There was good concordance between the values of FA/FI that were measured in this model and those calculated by computer simulation. No correction factor was required. Such a physical model may therefore be used to test new techniques of administration of volatile agents.
authors.affiliation: L'Air Liquide, Centre de Recherche Claude-Delorme, Jouy-en-Josas.
authors.forename: M H
authors.initials: MH
authors.lastname: Renaudin
authors.forename: H
authors.initials: H
authors.lastname: Deriaz
authors.forename: A
authors.initials: A
authors.lastname: Monnot
authors.forename: A
authors.initials: A
authors.lastname: Lienhart
mesh_terms: D000769:Anesthesia, Inhalation; D002302:Cardiac Output; D004737:Enflurane; D006221:Halothane; D006801:Humans; D007530:Isoflurane; D008962:Models, Theoretical; D012119:Respiration; D012995:Solubility
chemical_list: D004737:Enflurane; D007530:Isoflurane; D006221:Halothane
vernacular_title: Modélisation physique de l'anesthésie par inhalation.