Effect of phenytoin on the human neuronal activity and depth event-related potential in emotional task.
Neuronal activity and depth ERP were recorded from cortical areas and subcortical nuclei of three patients with diagnostic and/or therapeutic intracerebral electrodes while they were performing emotional task before and after phenytoin administration. Phenytoin acted as a bioelectrical modulator, in some cases increasing and in some cases decreasing the mean background neuronal firing level. In some few cases the more specific task-related effect of phenytoin was found as an inversion of the inhibitory response into the excitatory one in trials evoking negative emotions.
Bechtereva
N P
NP
Brain Center, St. Petersburg, Russia.
Abdullaev
Y G
YG
D001921:Brain / Q000187:drug effects / Q000502:physiology; D004644:Emotions / Q000502:physiology*; D005071:Evoked Potentials / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D010672:Phenytoin / Q000494:pharmacology*; D013647:Task Performance and Analysis
D010672:Phenytoin