title: The value of peritoneal dialysis in the treatment of severe ethanol intoxication in childhood revised.
abstract: We treated a girl aged 3.5 years (15 kg) with ethanol intoxication, using peritoneal dialysis. The blood ethanol concentration was 6.4 g/l (640 mg/dl; 138.9 mmol/l). It was calculated that the child drank a total amount of 67.2 g of ethanol (4.5 g/kg). The spontaneous ethanol elimination rate before peritoneal dialysis was 0.27 g/l (5.86 mmol/l) per hour; during peritoneal dialysis we found an ethanol elimination rate of 0.32 g/l (6.94 mmol/l) per hour, which was lower than expected. In childhood the ethanol elimination rate with peritoneal dialysis is only slightly faster in comparison to the high spontaneous elimination rate. We conclude that treatment of severe ethanol intoxication should include mainly the maintenance of the vital functions and the meticulous control of blood sugar levels and acid-base disturbances, especially in children. Indications for dialysis are complications caused by ethanol and resistant to supportive therapy, such as seizures, metabolic disturbances, persistent hypoglycemia and the possibility of combined intoxication with other dialysable drugs.
authors.affiliation: Department of Paediatrics, University Hospital, Ulm, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Woelfel
authors.forename: G
authors.initials: G
authors.lastname: Zeilinger
authors.forename: M A
authors.initials: MA
authors.lastname: Wendt-Göeknur
mesh_terms: D000435:Alcoholic Intoxication / Q000378:metabolism / Q000628:therapy*; D001786:Blood Glucose / Q000032:analysis; D002675:Child, Preschool; D015314:Dialysis Solutions / Q000008:administration & dosage; D000431:Ethanol / Q000008:administration & dosage* / Q000378:metabolism / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced / Q000628:therapy; D008657:Metabolic Clearance Rate / Q000502:physiology; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000379:methods*
chemical_list: D001786:Blood Glucose; D015314:Dialysis Solutions; D000431:Ethanol