Distribution of Alzheimer's disease-associated protein (ADAP) in 10 human brains.
ALZ50-based enzyme immunoassay was used to study distribution of Alzheimer's disease-associated protein (ADAP) in postmortem brain tissues of 5 Alzheimer's disease (AD) and 5 non-Alzheimer's disease (NAD) subjects. There are at least three AD-associated proteins, including A68. Levels are higher in brain regions with severe neuronal loss in AD: frontal, temporal, hippocampal cortex, and amygdala. No significant ADAP was found in the NAD samples (from 2 age-matched-1 clinically demented-and 3 younger subjects). ADAP levels in four regions of AD brains were not correlated to neuritic plaque count in corresponding regions of matching formaldehyde-fixed hemispheres.
Miller
B E
BE
Diagnostics Division, Abbott Laboratories, Abbott Park, IL 60064.
Whetsell
W O
WO
Chong
J K
JK
Ghanbari
H A
HA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000032:analysis*; D016874:Neurofibrillary Tangles / Q000473:pathology; D016875:tau Proteins
C054369:MAPT protein, human; D009419:Nerve Tissue Proteins; D016875:tau Proteins