Calcium channel blockers prevent stress-induced ulcers in rats.
Gastric mucosal damage induced by cold and restraint stress caused increase in gastric lipid peroxidation (LP) and decrease in gastric glutathione levels. Two calcium-channel blockers, verapamil and nicardipine, prevented stress-induced increase in gastric LP, as well as ulcer formation. Both calcium-channel blockers protected against stress-induced ulcers, and inhibition of LP may be among their mechanisms of action.
Yegen
B C
BC
Department of Biochemistry, Marmara University, School of Medicine, Haydarpasa, Istanbul, Turkey.
Alican
I
I
Yalçin
A S
AS
Oktay
S
S
D000818:Animals; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D009529:Nicardipine / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D012149:Restraint, Physical; D013270:Stomach / Q000187:drug effects; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications*; D014700:Verapamil / Q000494:pharmacology / Q000627:therapeutic use
D002121:Calcium Channel Blockers; D008054:Lipid Peroxides; D014700:Verapamil; D009529:Nicardipine; D005978:Glutathione