Ferruginous body counts in sputum as an index of past exposure to mineral fibres.
Previous work by our group among vermiculite miners exposed to fibrous tremolite demonstrated that asbestos body counts in sputum closely reflected intensity and duration of past exposure. In the present project sputum samples from nearly 600 volunteers from 11 cohorts of workers exposed to asbestos and other mineral fibres were found to contain much lower numbers of asbestos bodies than had been observed in vermiculite workers and these counts did not reliably reflect past levels of exposure. No evidence was found that occupational exposure to man-made mineral fibres led to any ferruginous body formation. Asbestos body counts appeared to differentiate between mesothelioma cases and controls and between levels of radiological asbestosis, but in both comparisons, based on small numbers, the power of discrimination was low. Substantial variation was found both in asbestos body and in macrophage counts in daily sampling of vermiculite workers but it was not sufficient to invalidate comparison between groups for epidemiological study. In individual subjects, however, little reliance can be put on results from a single sputum sample, particularly if negative.
McDonald
J C
JC
School of Occupational Health, McGill University, Montreal, Canada.
Sébastien
P
P
Case
B
B
McDonald
A D
AD
Dufresne
A
A
D000328:Adult; D000704:Analysis of Variance; D001194:Asbestos / Q000032:analysis*; D001195:Asbestosis / Q000175:diagnosis*; D016022:Case-Control Studies; D002452:Cell Count; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis*; D008264:Macrophages; D008654:Mesothelioma / Q000175:diagnosis*; D008667:Metalloproteins / Q000032:analysis*; D008875:Middle Aged; D008903:Minerals / Q000032:analysis; D009784:Occupational Diseases / Q000175:diagnosis*; D016273:Occupational Exposure / Q000032:analysis*; D013183:Sputum / Q000737:chemistry*
D008667:Metalloproteins; D008903:Minerals; D001194:Asbestos