Effects of salt restriction on renal growth and glomerular injury in rats with remnant kidneys.
Male Munich-Wistar rats underwent right nephrectomy and infarction of two thirds of the left kidney. Rats were randomly assigned to ingest standard chow (REM) or a moderately salt restricted chow (LS). A third group of rats were fed the low salt diet and were injected with an androgen (LSA). Eight weeks after ablation, glomerular volume and glomerular capillary radius were markedly increased in REM. This increase was prevented by the low salt diet, however, the antihypertrophic effect of the diet was overcome by androgen. Values for glomerular volume and capillary radius were similar in LSA and REM. Morphologic studies revealed that approximately 25% of glomeruli were abnormal in REM. Much less injury was observed in salt restricted rats, however, the protective effect of the low salt diet was significantly abrogated when renal growth was stimulated in salt restricted rats by androgen. Micropuncture studies revealed that glomerular pressure was elevated in all three groups and not affected by diet or androgen. Serum cholesterol was also similar in the three groups. These findings indicate that renal and glomerular hypertrophy are correlated with the development of glomerular injury after reduction in renal mass and suggest that dietary salt restriction lessens renal damage, at least in part, by inhibiting compensatory renal growth.
Lax
D S
DS
Department of Medicine, New York University Medical Center, New York.
Benstein
J A
JA
Tolbert
E
E
Dworkin
L D
LD
D000222:Adaptation, Physiological; D000818:Animals; D004039:Diet, Sodium-Restricted; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006984:Hypertrophy; D007668:Kidney / Q000254:growth & development / Q000473:pathology / Q000502:physiology*; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000517:prevention & control; D007678:Kidney Glomerulus / Q000187:drug effects / Q000293:injuries; D008297:Male; D009277:Nandrolone / Q000031:analogs & derivatives / Q000494:pharmacology; D000077603:Nandrolone Decanoate; D009392:Nephrectomy; D051381:Rats; D011919:Rats, Inbred Strains
D009277:Nandrolone; D000077603:Nandrolone Decanoate