title: Effects of growth hormone in patients receiving total parenteral nutrition following major gastrointestinal surgery.
abstract: The purpose of the present study was to determine whether the administration of a biosynthetic human growth hormone was capable of enhancing the efficacy of total parenteral nutrition. Patients (n = 38) who had undergone major gastrointestinal surgery were randomly divided into two groups. Group I (n = 20) treated only with PN, and Group II (n = 18) treated as in Group I plus human growth hormone (4 IU daily). Our study shows that the administration of human growth hormone produces a statistically significant increase in serum levels of growth hormone, somatomedin-C, transferrin, albumin and total proteins. It also causes a positive nitrogen balance from the first 24 hours onward. These findings suggest that the administration of human growth hormone produces an increase in protein synthesis, perhaps through somatomedin-C as mediator.
authors.affiliation: Department of Surgery, University of Granada, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Vara-Thorbeck
authors.forename: J A
authors.initials: JA
authors.lastname: Guerrero
authors.forename: M E
authors.initials: ME
authors.lastname: Ruiz-Requena
authors.forename: J
authors.initials: J
authors.lastname: Capitán
authors.forename: M
authors.initials: M
authors.lastname: Rodriguez
authors.forename: J
authors.initials: J
authors.lastname: Rosell
authors.forename: K
authors.initials: K
authors.lastname: Mekinassi
authors.forename: M
authors.initials: M
authors.lastname: Maldonado
authors.forename: R
authors.initials: R
authors.lastname: Martin
mesh_terms: D000328:Adult; D000368:Aged; D001798:Blood Proteins / Q000187:drug effects; D003131:Combined Modality Therapy; D005767:Gastrointestinal Diseases / Q000601:surgery; D013006:Growth Hormone / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D010289:Parenteral Nutrition, Total; D011182:Postoperative Care / Q000379:methods*; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D001798:Blood Proteins; D011994:Recombinant Proteins; D013006:Growth Hormone