title: Elevated lactate and alkalosis in chronic human brain infarction observed by 1H and 31P MR spectroscopic imaging.
abstract: The goal of this study was to investigate lactate and pH distributions in subacutely and chronically infarcted human brains. Magnetic resonance spectroscopic imaging (MRSI) was used to map spatial distributions of 1H and 31P metabolites in 11 nonhemorrhagic subacute to chronic cerebral infarction patients and 11 controls. All six infarcts containing lactate were alkalotic (pHi = 7.20 +/- 0.04 vs. 7.05 +/- 0.01 contralateral, p less than 0.01). This finding of elevated lactate and alkalosis in chronic infarctions does not support the presence of chronic ischemia; however, it is consistent with the presence of phagocytic cells, gliosis, altered buffering mechanisms, and/or luxury perfusion. Total 1H and 31P metabolites were markedly reduced (about 50% on average) in subacute and chronic brain infarctions (p less than 0.01), and N-acetyl aspartate (NAA) was reduced more (approximately 75%) than other metabolites (p less than 0.01). Because NAA is localized in neurons, selective NAA reduction is consistent with pathological findings of a greater loss of neurons than glial cells in chronic infarctions.
authors.affiliation: MR Unit, Department of Veterans Affairs Medical Center, San Francisco, CA 94121.
authors.forename: J W
authors.initials: JW
authors.lastname: Hugg
authors.forename: J H
authors.initials: JH
authors.lastname: Duijn
authors.forename: G B
authors.initials: GB
authors.lastname: Matson
authors.forename: A A
authors.initials: AA
authors.lastname: Maudsley
authors.forename: J S
authors.initials: JS
authors.lastname: Tsuruda
authors.forename: D F
authors.initials: DF
authors.lastname: Gelinas
authors.forename: M W
authors.initials: MW
authors.lastname: Weiner
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000471:Alkalosis / Q000378:metabolism*; D002544:Cerebral Infarction / Q000378:metabolism*; D005260:Female; D006801:Humans; D006859:Hydrogen; D007773:Lactates / Q000378:metabolism*; D019344:Lactic Acid; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D010758:Phosphorus; D012815:Signal Processing, Computer-Assisted
chemical_list: D007773:Lactates; D010758:Phosphorus; D019344:Lactic Acid; D006859:Hydrogen