title: Chromosomal abnormalities associated with a single umbilical artery.
abstract: A single umbilical artery was seen in 10 out of 117 cytogenetically abnormal pregnancies. The abnormal karyotypes found to be associated with a single umbilical artery were trisomy 18 (n = 5), monosomy X (n = 2), triploidy (n = 1), sex chromosome (47,XYY; n = 1) and translocation (46t(X,5)(q13p15);n = 1). With the exception of the translocation case, all cases with a single umbilical artery had anatomical defects which were detectable ultrasonographically. This suggests that a single umbilical artery alone is not an indication for prenatal fetal karyotyping.
authors.affiliation: Department of Pathology, Queen Victoria Hospital, Australia.
authors.forename: T Y
authors.initials: TY
authors.lastname: Khong
authors.forename: K
authors.initials: K
authors.lastname: George
mesh_terms: D002869:Chromosome Aberrations / Q000000981:diagnostic imaging* / Q000235:genetics*; D025063:Chromosome Disorders; D002887:Chromosomes, Human, Pair 18; D002895:Chromosomes, Human, Pair 5; D005260:Female; D006801:Humans; D011247:Pregnancy; D014314:Trisomy; D014463:Ultrasonography; D014469:Umbilical Arteries / Q000002:abnormalities*; D014960:X Chromosome; D014998:Y Chromosome