Interchromosomal gene conversion as a possible mechanism for explaining divergence patterns of ZFY-related genes.
The divergence pattern of mammalian ZFY-related genes from human (ZFY and ZFX) and mouse (Zfy-1 and Zfx) was reexamined on the basis of nucleotide substitutions at the synonymous codon-alternating positions. It is possible to explain the unusual divergence pattern of the mammalian Y-linked ZF genes by interchromosomal gene conversion by X-linked ZF genes. Furthermore, the rates of evolution of mammalian X- and Y-linked ZF genes were shown to agree well with those expected from our model.
Hayashida
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Kuma
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Miyata
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D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics*; D005785:Gene Conversion; D014644:Genetic Variation; D006801:Humans; D051741:Kruppel-Like Transcription Factors; D051379:Mice; D014157:Transcription Factors; D016335:Zinc Fingers / Q000235:genetics*
D004268:DNA-Binding Proteins; D051741:Kruppel-Like Transcription Factors; D014157:Transcription Factors; C054430:ZFY protein, human; C501342:Zfy1 protein, mouse; C062076:zinc finger protein, X-linked