Effects of unsaturated and saturated dietary plant sterols on their serum contents.
Rapeseed oil fed to 24 hypercholesterolemic patients (50 g/day) reduced serum cholesterol (-8.5%) and cholestanol concentrations but increased those of campesterol and sitosterol. Continuation of rapeseed oil alone or with added sitosterol (625 mg/day) or sitostanol (630 mg/day) had no further effect on serum cholesterol. Rapeseed oil with sitosterol increased further its own proportion to cholesterol in serum but reduced that of campesterol while rapeseed oil with sitostanol reduced the proportions of both sitosterol and campesterol proportionately to the pretreatment values. The changes in the campesterol and sitosterol proportions were negatively and positively related to each other during the sitosterol and sitostanol additions, respectively. Thus, concentrations of unsaturated plant sterols in serum reflect their dietary intakes, saturated plant sterols are virtually not absorbed, plant sterols interfere with absorption of unsaturated structurally different plant sterols and cholestanol, and plant sterol-induced reduction of sterol absorption may be positively related to absorption efficiency of sterols.
Vanhanen
H T
HT
Second Department of Medicine, University of Helsinki, Finland.
Miettinen
T A
TA
D000328:Adult; D001835:Body Weight / Q000187:drug effects; D001937:Brassica; D002784:Cholesterol / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology; D004041:Dietary Fats / Q000494:pharmacology; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010840:Phytosterols; D010938:Plant Oils / Q000378:metabolism / Q000494:pharmacology*; D012855:Sitosterols / Q000097:blood / Q000494:pharmacology*
D004041:Dietary Fats; D010840:Phytosterols; D010938:Plant Oils; D012855:Sitosterols; C021273:campesterol; C025473:gamma-sitosterol; D002784:Cholesterol; C021255:stigmastanol