Immunohistochemical identification of Penicillium marneffei by monoclonal antibody.
We present an experimental study on the immunohistochemical identification of Penicillium marneffei in paraffin-embedded, formalin-fixed tissue. The monoclonal antibody EB-A1 detects a specific galactomannan that appears to have at least one epitope identical in P. marneffei and Aspergillus sp. This immunohistochemical approach could be useful in the diagnosis of a rare diseae, penicilliosis marneffei, which proves to be difficult to identify by conventional microscopy.
Arrese Estrada
J
J
Department of Dermatopathology, CHU du Sart Tilman, Liège, Belgium.
Stynen
D
D
Van Cutsem
J
J
Piérard-Franchimont
C
C
Piérard
G E
GE
D000818:Animals; D000911:Antibodies, Monoclonal; D001230:Aspergillus / Q000276:immunology; D006168:Guinea Pigs; D016612:Paraffin Embedding / Q000379:methods*; D010407:Penicillium / Q000276:immunology / Q000302:isolation & purification*
D000911:Antibodies, Monoclonal