[The effect of portal venous drainage on graft survival and function in rat whole pancreaticoduodenal transplantation].
A whole pancreaticoduodenal transplant model with portal venous drainage was achieved in the rat, and effect of venous drainage from pancreas grafts into the portal vein on the functional graft survival and long-term glucose metabolism was investigated. In allogeneic series between ACI (RT1a) donors and streptozotocin-induced diabetic Lewis (RT1l) recipients (nonfasting plasma glucose greater than or equal to 400 mg/dl), the mean survival time of pancreas transplants determined by recurrent hyperglycemia (greater than or equal to 200 mg/gl) in rats with portal venous drainage (PV-group: 8.9 +/- 1.3 days) was slightly longer than that in rats with systemic venous drainage (SV-group: 8.3 +/- 0.9 days), but statistically insignificant. In the syngeneic series using Lewis rats, K-values (%/min) in IV-GTT at 1, 2 and 3 months after pancreas transplantation were, respectively, 1.5 +/- 1.0, 2.0 +/- 0.6 and 2.3 +/- 0.7 in PV-group, and 1.2 +/- 0.3, 1.2 +/- 0.4 and 1.8 +/- 0.5 in SV-group. Peripheral IRI (microU/ml) levels before glucose load were higher in both groups (PV-group, 15.1 +/- 10.5: SV-group, 22.8 +/- 16.2) at 3 months than in normal control (7.9 +/- 1.6: p greater than 0.05). These results indicate that the portal venous drainage in pancreas transplants has no remarkable profit in graft survival and that it can provide more physiological glucose control but cannot normalize insulin concentration.
Mitsuo
M
M
Second Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Nakai
I
I
Oda
T
T
Oka
T
T
D000818:Animals; D004322:Drainage; D004386:Duodenum / Q000637:transplantation*; D005947:Glucose / Q000378:metabolism; D006085:Graft Survival; D008297:Male; D010179:Pancreas / Q000502:physiology*; D016035:Pancreas Transplantation / Q000379:methods; D011169:Portal Vein; D051381:Rats; D011912:Rats, Inbred ACI; D011917:Rats, Inbred Lew
D005947:Glucose