Inhibition of proliferation of normal and transformed neural cells by blood group-related oligosaccharides.
A synthetic tetrasaccharide structurally related to blood groups and selectin ligands inhibited division of astrocytes, gliomas, and neuroblastomas at micromolar concentrations. The compound was cytostatic for primary astrocytes in culture, but cytotoxic for fast proliferating cell lines.
Santos-Benito
F F
FF
Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.
Fernández-Mayoralas
A
A
Martín-Lomas
M
M
Nieto-Sampedro
M
M
D000818:Animals; D001789:Blood Group Antigens / Q000378:metabolism*; D002240:Carbohydrate Sequence; D002455:Cell Division; D008969:Molecular Sequence Data; D009474:Neurons / Q000166:cytology*; D009844:Oligosaccharides / Q000378:metabolism*; D051381:Rats; D013329:Structure-Activity Relationship
D001789:Blood Group Antigens; D009844:Oligosaccharides