title: Synthesis and inhibitory effects of 1,2,4-triazole derivatives on platelet aggregation.
abstract: Various derivatives of triazole substituted in the 2-position were prepared, and their activity on platelet aggregation tested. Compounds 4 and 14 had the most powerful action. These agents were thought to inhibit platelet aggregation via an inhibition of the cyclo-oxygenase-peroxidase complex (PGS complex), preventing synthesis of prostaglandins.
authors.affiliation: Department of Chemical Pharmacy, Faculty of Pharmacy, Limoges, France.
authors.forename: J F
authors.initials: JF
authors.lastname: Lagorce
authors.forename: T
authors.initials: T
authors.lastname: Moulard
authors.forename: C
authors.initials: C
authors.lastname: Raby
mesh_terms: D016718:Arachidonic Acid / Q000378:metabolism; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D016861:Cyclooxygenase Inhibitors; D010975:Platelet Aggregation Inhibitors; D014230:Triazoles; D016718:Arachidonic Acid