Ring chromosome in parosteal osteosarcoma. Clinical and diagnostic significance.
In this study, two specimens of a parosteal osteosarcoma, a rare primary bone neoplasm comprising only 3-6% of all osteosarcomas, were cytogenetically analyzed utilizing standard techniques. In contrast to the complex karyotypes previously reported in osteosarcoma, this particular histologic subtype was characterized by a single chromosomal aberration, a ring chromosome. Ring chromosomes have been described as characteristic for two other low-grade malignant mesenchymal neoplasms, well-differentiated liposarcoma and dermatofibrosarcoma protuberans. We propose that the observation of a ring chromosome in osteosarcoma also correlates with a low-grade malignant potential.
Sinovic
J F
JF
Department of Pathology, University of Nebraska Medical Center, Omaha, 68198-5540.
Bridge
J A
JA
Neff
J R
JR
D000293:Adolescent; D005266:Femoral Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D008297:Male; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D011003:Ploidies; D011859:Radiography; D012303:Ring Chromosomes