title: Single-dose and steady-state pharmacokinetics of sabeluzole in senile dementia of Alzheimer type patients.
abstract: The single- and repeated-dose pharmacokinetics of sabeluzole have been determined in six elderly patients with [senile] dementia of the Alzheimer type. After a single oral dose of 10 mg sabeluzole, the peak plasma concentration was attained at 1 to 4 h; it averaged 42 ng.ml-1. On repeated dosing (10 mg b.d.), steady-state was virtually attained after 3 days of treatment. Steady-state mean trough and peak plasma concentrations fluctuated between 53 and 94 ng.ml-1. The mean terminal half-life after a single dose and at steady-state was of the order of 33 h. Sabeluzole was well tolerated and at the end of treatment, no systematic changes in blood haematology, biochemistry or urinalysis were seen.
authors.affiliation: Department of Neurology, General Hospital Middelheim, Belgium.
authors.forename: P P
authors.initials: PP
authors.lastname: De Deyn
authors.forename: V
authors.initials: V
authors.lastname: Van de Velde
authors.forename: W
authors.initials: W
authors.lastname: Verslegers
authors.forename: J
authors.initials: J
authors.lastname: Saerens
authors.forename: B A
authors.initials: BA
authors.lastname: Pickut
authors.forename: B
authors.initials: B
authors.lastname: Clincke
authors.forename: R
authors.initials: R
authors.lastname: Woestenborghs
authors.forename: A
authors.initials: A
authors.lastname: Van Peer
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013844:Thiazoles / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D010880:Piperidines; D013844:Thiazoles; C055163:sabeluzole