title: A new antitumor antibiotic product, demethylchartreusin. Isolation and biological activities.
abstract: A new antitumor antibiotic, 3''-demethylchartreusin was isolated from the culture broth of Streptomyces chartreusis, as a minor component of crude chartreusin. It is structurally related to chartreusin, containing same aglycone of chartreusin, but different sugar moieties. 3''-Demethylchartreusin exhibits some potent inhibitory activities against murine tumors.
authors.affiliation: Biochemistry Research Laboratory, Ishihara Sangyo Kaisha, Ltd., Shiga, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Aoyama
authors.forename: T
authors.initials: T
authors.lastname: Katayama
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Kon
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001578:Benzopyrans / Q000302:isolation & purification / Q000494:pharmacology; D005285:Fermentation; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology; D051379:Mice; D013302:Streptomyces / Q000378:metabolism
chemical_list: D000903:Antibiotics, Antineoplastic; D001578:Benzopyrans; D006027:Glycosides; C076082:3''-demethylchartreusin