[Platelet hyperaggregation induced by an antiplatelet monoclonal antibody in a female patient with essential thrombocythemia of childhood].
Essential thrombocythemia (ET) is a chronic myeloproliferative disease, rarely observed in pediatric age, characterized by a persistently increased platelet count. Abnormalities of platelet function observed in ET patients may be, at least in part, responsible for the thrombohemorrhagic complications. The authors report about a pediatric patient affected by ET, showing an abnormal platelet response following stimulation by anti-platelet monoclonal antibody. Such finding may be attributable to a structural abnormality of the platelet fibrinogen receptor or to post-receptor alterations.
Perutelli
P
P
Laboratorio di Ematologia, Istituto Giannina Gaslini, Genova Quarto.
Biglino
P
P
Molinari
A C
AC
Boeri
E
E
Mori
P G
PG
D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D000918:Antibody Specificity; D001792:Blood Platelets / Q000737:chemistry / Q000276:immunology*; D001798:Blood Proteins / Q000032:analysis; D002648:Child; D005260:Female; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*; D013920:Thrombocythemia, Essential / Q000097:blood*
D000911:Antibodies, Monoclonal; D001798:Blood Proteins
Iperaggregazione piastrinica indotta da un anticorpo monoclonale anti-piastrine in una paziente con trombocitemia essenziale in età pediatrica.