title: Age dependency of the susceptibility of rats to aminooxyacetic acid seizures.
abstract: Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats. Highest susceptibility to AOAA seizures was observed in 7-14-day-old rat pups. The lowest susceptibility was recorded in 10-20 month-old rats. AOAA seizures in 14-day-old rats were blocked by clonazepam and valproate, but not by phenobarbital, carbamazepine, diphenylhydantoin, trimethadione or ethosuximide. Morphological analysis of brains from 14-day- and 3-month-old rats which experienced AOAA seizures did not reveal epilepsy-related damage. These observations suggest that immature rat brain is highly prone to convulsions induced by AOAA and that such convulsions are difficult to control by available antiepileptic treatment.
authors.affiliation: Department of Pharmacology, Medical School, Lublin, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Turski
authors.forename: M
authors.initials: M
authors.lastname: Dziki
authors.forename: J
authors.initials: J
authors.lastname: Parada
authors.forename: Z
authors.initials: Z
authors.lastname: Kleinrok
authors.forename: E A
authors.initials: EA
authors.lastname: Cavalheiro
mesh_terms: D000375:Aging / Q000502:physiology*; D000625:Aminooxyacetic Acid / Q000633:toxicity*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use; D001831:Body Temperature / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D002220:Carbamazepine / Q000494:pharmacology; D002998:Clonazepam / Q000494:pharmacology; D004198:Disease Susceptibility; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D005968:Glutamate Decarboxylase / Q000378:metabolism; D008297:Male; D009928:Organ Specificity; D010634:Phenobarbital / Q000494:pharmacology; D010672:Phenytoin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology*; D013997:Time Factors; D014635:Valproic Acid / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D000927:Anticonvulsants; D000625:Aminooxyacetic Acid; D002220:Carbamazepine; D005680:gamma-Aminobutyric Acid; D002998:Clonazepam; D014635:Valproic Acid; D010672:Phenytoin; D005968:Glutamate Decarboxylase; D010634:Phenobarbital