title: Topical indomethacin in the treatment of chronic cystoid macular edema.
abstract: Eighty percent of 30 eyes with chronic cystoid macular edema (CME) after cataract extraction achieved improved visual acuity of three or more lines when treated with 1% indomethacin eye drops. Of these patients 53% demonstrated an "on/off" phenomenon induced by the initiation and cessation of treatment documented by visual acuity measurements and fluorescein angiography. This "on/off" phenomenon suggests that there is a direct relationship between the use of 1% indomethacin eye drops and the resolution of chronic CME after cataract extraction. Previous studies on the treatment of CME with indomethacin have not addressed the use of indomethacin eye drops for chronic CME.
authors.affiliation: Doris Stein Eye Research Center, Jules Stein Eye Institute, Department of Ophthalmology UCLA School of Medicine 90024-7007.
authors.forename: M
authors.initials: M
authors.lastname: Peterson
authors.forename: M O
authors.initials: MO
authors.lastname: Yoshizumi
authors.forename: R
authors.initials: R
authors.lastname: Hepler
authors.forename: B
authors.initials: B
authors.lastname: Mondino
authors.forename: A
authors.initials: A
authors.lastname: Kreiger
mesh_terms: D000287:Administration, Topical; D002387:Cataract Extraction / Q000009:adverse effects; D002908:Chronic Disease; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000627:therapeutic use*; D007910:Lenses, Intraocular; D008269:Macular Edema / Q000188:drug therapy* / Q000209:etiology; D012189:Retrospective Studies; D014792:Visual Acuity
chemical_list: D007213:Indomethacin