title: Nodular vasculitis associated with propylthiouracil therapy.
abstract: Cutaneous vasculitis is a rare complication of propylthiouracil therapy. We describe a patient who presented with lower extremity subcutaneous nodules, hemorrhagic bullae, and necrotic ulcers during treatment with this agent. Examination of a skin biopsy specimen revealed nodular vasculitis. This type of vasculitis has not been described in association with propylthiouracil therapy before. Nodular vasculitis not associated with the drug is characterized by a chronic protracted course, whereas in the patient reported the lesions rapidly regressed when use of the drug was discontinued.
authors.affiliation: Department of Internal Medicine, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Wolf
authors.forename: A
authors.initials: A
authors.lastname: Ben-Yehuda
authors.forename: E
authors.initials: E
authors.lastname: Okon
authors.forename: Y
authors.initials: Y
authors.lastname: Naparstek
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D011441:Propylthiouracil / Q000009:adverse effects*; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000139:chemically induced* / Q000473:pathology
chemical_list: D011441:Propylthiouracil