Augmentation of host resistance to Candida albicans infection in ascites tumor-bearing mice.
We found that the number of peripheral blood polymorphonuclear leukocytes (PMN) dramatically increased in both sarcoma 180 (S-180) and MM-46 mammary carcinoma (MM-46) ascites tumor-bearing mice, and mice required a remarkable resistance to Candida albicans infection via intravenous route. When the resistance was determined by number of cells of C. albicans in the kidney, a significant decrease in the number of fungal cells was observed in the kidneys of infected ascites tumor-bearing mice. An increase of active oxygen levels of PMN from ascites tumor-bearing mice was observed, suggesting that this factor is important in developing of resistance in ascites tumor-bearing mice. Additionally, a culture supernatant of tumor cells co-cultivated with bone-marrow cells in vitro increased the number of granulocytes and macrophages differentiated from the bone-marrow cells.
Okawa
Y
Y
Second Department of Hygienic Chemistry, Tohoku College of Pharmacy, Miyagi, Japan.
Murata
Y
Y
Kobayashi
M
M
Suzuki
M
M
Suzuki
S
S
D000818:Animals; D002176:Candida albicans; D002177:Candidiasis / Q000276:immunology*; D015169:Colony Count, Microbial; D006098:Granulocytes / Q000276:immunology; D007113:Immunity, Innate; D007958:Leukocyte Count; D008264:Macrophages / Q000276:immunology; D008325:Mammary Neoplasms, Experimental / Q000276:immunology* / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D009504:Neutrophils / Q000276:immunology; D012510:Sarcoma 180 / Q000276:immunology* / Q000382:microbiology