title: Interstitial laser hyperthermia: a new approach for treating liver metastases.
abstract: The palliative management of hepatic metastases remains unsatisfactory. There is a need for a simple non invasive technique which can stop or retard the rate of tumour growth. In principle, Interstitial Laser hyperthermia may fulfil such a role. In experimental studies, this technique produced precise in situ necrosis within solid organs which healed safely. In a pilot feasibility study, we treated ten patients with a total of 18 hepatic metastases on 31 occasions using a percutaneous approach to achieve an overall objective response rate of 44%. The treatment proved simple to perform, was well tolerated and produced radiological evidence of necrosis in small metastases (diameter less than or equal to 3 cm). However, further research is required before the technique can be regarded as established. Its future role in most cases will be to control the growth of discrete hepatic metastases unsuitable for resection. In instances where the extent of necrosis can be matched accurately to tumour volume, the potential for cure exists.
authors.affiliation: Department of Surgery, University College and Middlesex Hospitals, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Masters
authors.forename: A C
authors.initials: AC
authors.lastname: Steger
authors.forename: W R
authors.initials: WR
authors.lastname: Lees
authors.forename: K M
authors.initials: KM
authors.lastname: Walmsley
authors.forename: S G
authors.initials: SG
authors.lastname: Bown
mesh_terms: D000368:Aged; D005500:Follow-Up Studies; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D053685:Laser Therapy; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D008875:Middle Aged; D009336:Necrosis; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography