Tet determinants provide poor protection against some tetracyclines: further evidence for division of tetracyclines into two classes.
Atypical tetracyclines were active against Escherichia coli and Staphylococcus aureus strains containing determinants that mediate resistance to typical tetracyclines by efflux (Tet B and Tet K) or ribosomal protection (Tet M) mechanisms. The results support recently published data that tetracyclines are divisible into at least two classes on the basis of their modes of action.
Oliva
B
B
Department of Microbial Biochemistry and Genetics, American Cyanamid, Lederle Laboratories, Pearl River, New York 10965.
Chopra
I
I
D004926:Escherichia coli / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects*; D013754:Tetracyclines / Q000145:classification / Q000494:pharmacology*
D013754:Tetracyclines