[Passive Ca2+ influx into vesicles of the sarcoplasmic reticulum, modified by succinic anhydride].
Treatment of the sarcoplasmic reticulum (SR) vesicles with succinic anhydride in concentration of 1-2 mM modifies about 20% of amino groups. It increases initial rate and changes the pH-dependence of the passive influx of Ca2+ into vesicles and does not affect either Ca(2+)-binding or maximal passive Ca(2+)-loading of the SR vesicles. It is supposed that this effect may be caused by modification of the Ca-channel gating behaviour as a result of replacement of positive surface amino groups by carboxyl groups.
Tugay
V A
VA
Diadiusha
G P
GP
Zimina
V P
VP
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002413:Cations, Divalent; D006863:Hydrogen-Ion Concentration; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D011817:Rabbits; D012519:Sarcoplasmic Reticulum / Q000187:drug effects / Q000378:metabolism*; D013387:Succinic Anhydrides / Q000494:pharmacology*
D002413:Cations, Divalent; D013387:Succinic Anhydrides; C031801:succinic anhydride; D002118:Calcium
Passivnyĭ vkhod Ca2+ v vezikuly sarkoplazmaticheskogo retikuluma, modifitsirovannye iantarnym angidridom.