title: Inhalation toxicity of chromium from Whetlerite dust in rats.
abstract: The acute inhalation toxicity and metabolic fate of chromium and copper from Whetlerite dust in rats were investigated. Groups of male and female, Sprague-Dawley rats were exposed to Whetlerite dust and base carbon dust as outlined in the OECD Limit Test guidelines. At 14, 28 and 180 days post-exposure, rats were evaluated for gross pathological changes and tissues were collected for chromium and copper determination. Four deaths occurred during or post-exposure, but did not appear to be compound related. No gross pathological changes were observed at necropsy in either group. Organ chromium concentrations were below detection limits of 0.5 micrograms Cr/g dry tissue in both exposure groups. According to OECD guidelines, neither Whetlerite dust nor base carbon dust demonstrated an acute inhalation toxicity.
authors.affiliation: U.S. Army Chemical Research, Development and Engineering Center, Toxicology Division, SMCCR-RST-I, Aberdeen Proving Ground, MD 21010-5423.
authors.forename: R
authors.initials: R
authors.lastname: Hilaski
authors.forename: S
authors.initials: S
authors.lastname: Katz
authors.forename: H
authors.initials: H
authors.lastname: Salem
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D002244:Carbon / Q000493:pharmacokinetics / Q000633:toxicity*; D002857:Chromium / Q000493:pharmacokinetics / Q000633:toxicity*; D004391:Dust; D005260:Female; D008297:Male; D008452:Maximum Allowable Concentration; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
chemical_list: D004391:Dust; C062160:Whetlerite; D002857:Chromium; D002244:Carbon