Linkage analysis and predicting genetic disease.
Linkage analysis is an important and clinically applicable method of predicting risk for genetic disorders and traits. When a gene cannot be detected directly, evaluation of a closely linked marker may be used in risk assessment. This review of linkage analysis provides basic information and examples of the application of these methods in genetic counseling situations.
Boughman
J A
JA
Department of Obstetrics and Gynecology, University of Maryland School of Medicine, Baltimore.
Stick
M J
MJ
Peterson
D A
DA
Cohen
M M
MM
D002874:Chromosome Mapping; D005260:Female; D005817:Genetic Counseling; D030342:Genetic Diseases, Inborn / Q000175:diagnosis* / Q000235:genetics; D008040:Genetic Linkage; D015894:Genome, Human; D006801:Humans; D008297:Male; D010375:Pedigree