Sites of synthesis of chromogranins A and B in the human brain.
The sites of synthesis of the chromogranins A and B, and their potential processed peptides, were examined by quantitating the levels of chromogranin A and B mRNA in various regions of the human brain by Northern blot analysis. Chromogranin A and B mRNA expression in the brain is region-specific and confined to grey matter. In situ hybridization histochemistry detected chromogranin A and B mRNA in pyramidal neurons of human cerebral cortex. Cell-specific expression in subpopulations of cerebrocortical neurons suggest that chromogranin A and B gene products may play a role in central neuronal function.
Erickson
J D
JD
Unit on Molecular and Cellular Neurobiology, NIMH/ADAMHA, Bethesda, Maryland 20892.
Lloyd
R
R
Trojanowski
J Q
JQ
Iacangelo
A
A
Eiden
E
E
D001921:Brain / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D053379:Chromogranin A; D002864:Chromogranins / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D009693:Nucleic Acid Hybridization; D009838:Oligodeoxyribonucleotides; D009928:Organ Specificity; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
D053379:Chromogranin A; D002864:Chromogranins; D009838:Oligodeoxyribonucleotides; D012333:RNA, Messenger