Reduction of NGF protein level in rat dorsal hippocampus following administration of kainic acid.
Intraperitoneal administration of kainic acid (KA) into adult rats caused a profound increase in nerve growth factor (NGF) mRNA and a significant reduction of NGF protein level in the hippocampus. Diazepam pretreatment suppressed both. The reduction of NGF level was apparent in the dorsal hippocampus at 2 h after KA administration, but a marked elevation of NGF protein was observed in the ventral hippocampus at 4 h. These results suggest that non-N-methyl-D-aspartate (NMDA) receptor agonists negatively influence NGF synthesis or stimulate NGF protein degradation in the dorsal hippocampus involving the CA1 sector.
Hashimoto
Y
Y
Institute of Biological Science, Mitsui Pharmaceuticals, Inc., Chiba, Japan.
Omae
F
F
Furukawa
S
S
D000818:Animals; D015152:Blotting, Northern; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D007124:Immunoenzyme Techniques; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D009414:Nerve Growth Factors / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D009414:Nerve Growth Factors; D003975:Diazepam; D007608:Kainic Acid