title: Cardiac function and Fourier phase data from simulated Wolff-Parkinson-White syndrome in a baboon model.
abstract: The diagnostic value of Fourier phase analysis and planar scintigraphy in Wolff-Parkinson-White (WPW) syndrome has been suspect. This study investigates phase analytical data from planar radionuclide ventriculography of six baboons with simulated WPW syndrome by means of implanted electrodes. An electrode in the atrium controlled the heart rate and a subsequent stimulation was delivered by electrodes placed at different sites on the ventricles, delayed to cause the characteristic delta wave of the WPW syndrome. Sensitivity for accurately-localizing variously-situated first points of activation (FPAs) from the Fourier phase images was found highest for premature right ventricular (RV) activation, and for atrioventricular (AV) delays around 125 msec. Other sites were subject to artifacts. Changes in cardiac function, phase delay, and histogram parameters were not statistically meaningful.
authors.affiliation: AEC Institute for Life Sciences, Department of Internal Medicine, University of Pretoria, South Africa.
authors.forename: I C
authors.initials: IC
authors.lastname: Dormehl
authors.forename: A L
authors.initials: AL
authors.lastname: van Gelder
authors.forename: N
authors.initials: N
authors.lastname: Hugo
authors.forename: J J
authors.initials: JJ
authors.lastname: Stanton
authors.forename: I F
authors.initials: IF
authors.lastname: Redelinghuys
mesh_terms: D000818:Animals; D016477:Artifacts; D002302:Cardiac Output / Q000502:physiology; D004567:Electrodes, Implanted; D005583:Fourier Analysis; D007091:Image Processing, Computer-Assisted; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology; D010215:Papio; D015635:Radionuclide Ventriculography / Q000379:methods*; D012680:Sensitivity and Specificity; D013318:Stroke Volume / Q000502:physiology; D014927:Wolff-Parkinson-White Syndrome / Q000000981:diagnostic imaging*