[Inhibition of the tumoral growth induced by the injection of histo-incompatible cells producing interleukin-2].
In murine models, we show that the growth of a transplanted tumor can be controlled when allogeneic or xenogeneic cells expressing high levels of interleukin-2 are co-injected with the syngeneic tumor cells. Thus, genetically modified allogeneic or xenogeneic cells could have some therapeutic potential as vectors for transient cytokine gene expression.
Roth
C
C
Unité de Biologie moléculaire du Gène, U. 277 I.N.S.E.R.M., Institut Pasteur, Paris.
Mir
L M
LM
Cressent
M
M
Quintin-Colonna
F
F
Belehradek
J
J
Ley
V
V
Fradelizi
D
D
Kourilsky
P
P
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D007376:Interleukin-2 / Q000032:analysis / Q000494:pharmacology*; D008175:Lung Neoplasms / Q000473:pathology; D012515:Mast-Cell Sarcoma / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation / Q000473:pathology*; D012513:Sarcoma, Experimental / Q000473:pathology
D007376:Interleukin-2
Inhibition de la croissance tumorale induite par l'injection de cellules histo-incompatibles produisant de l'interleukine-2.