[In vitro sensitivity to antibiotics of genital mycoplasmas isolated in Toulouse. Study of new molecules (macrolides and quinolones)].
The minimal metabolism-inhibiting concentrations (MMC) of 11 antibiotics were determined for 40 strains each of M. hominis and U. urealyticum using a terminal color change broth method. All strains were recovered in 1990. Resistance to tetracycline (MMC greater than 8 mg/l) was found for 12.5% of strains of M. hominis and U. urealyticum, as compared with 5% in 1985. Rokitamycin was the most active macrolide against M. hominis (MMC 90: 0.06 mg/l). U. urealyticum strains were susceptible to all the macrolides tested, with the greatest activities being seen for rokitamycin and clarithromycin (MMC 90: 0.06 mg/l and 0.12 mg/l respectively). Sparfloxacin was the most active quinolone against both species. Human clinical trials designed to evaluate these new molecules for the treatment of mycoplasmal and ureaplasmal genital infections are warranted.
Bauriaud
R
R
Groupe Etude et Prévention des Maladies Transmissibles Sexuellement, Laboratoire Central de Microbiologie, Hôpital Purpan, Toulouse, France.
Séror
C
C
Lareng
M B
MB
Lefèvre
J C
JC
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004917:Erythromycin / Q000031:analogs & derivatives / Q000494:pharmacology*; D005260:Female; D005602:France; D005831:Genital Diseases, Female / Q000382:microbiology; D005832:Genital Diseases, Male / Q000382:microbiology; D006801:Humans; D066298:In Vitro Techniques; D007933:Leucomycins / Q000494:pharmacology*; D008297:Male; D008826:Microbial Sensitivity Tests; D009174:Mycoplasma / Q000187:drug effects*; D013754:Tetracyclines / Q000494:pharmacology*; D016990:Ureaplasma urealyticum / Q000187:drug effects*
D042462:4-Quinolones; D000890:Anti-Infective Agents; D007933:Leucomycins; D013754:Tetracyclines; D004917:Erythromycin
Sensibilité in vitro aux antibiotiques des mycoplasmes génitaux isolés à Toulouse. Etude de nouvelles molécules (macrolides et quinolones).