title: Detection of HIV-1 genome in leukocytes of human colostrum from anti-HIV-1 seropositive mothers.
abstract: In order to obtain more information about the presence of HIV-1 in mononuclear cells of colostrum, research was carried out on both the HIV-1 genome in the cellular fraction of colostrum and the viral antibody in cell-free colostrum of eight anti-HIV-1 seropositive asymptomatic mothers. In five cases cell fractions of the colostrum harbored HIV-1 genome by DNA-DNA and DNA-RNA in situ hybridization, whereas viral antibody were detected in all cell-free colostrum specimens. The data confirms the colostrum as a possible route of HIV-1 infection.
authors.affiliation: Institute of Infectious Diseases, University of Rome La Sapienza, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Vonesch
authors.forename: E
authors.initials: E
authors.lastname: Sturchio
authors.forename: A C
authors.initials: AC
authors.lastname: Humani
authors.forename: P
authors.initials: P
authors.lastname: Cordiali Fei
authors.forename: D
authors.initials: D
authors.lastname: Cosenza
authors.forename: F
authors.initials: F
authors.lastname: Caprilli
authors.forename: M
authors.initials: M
authors.lastname: Pezzella
mesh_terms: D000328:Adult; D003126:Colostrum / Q000382:microbiology*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D016679:Genome, Viral; D015483:HIV Antibodies / Q000032:analysis; D006679:HIV Seropositivity / Q000276:immunology / Q000382:microbiology*; D015497:HIV-1 / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007231:Infant, Newborn; D007962:Leukocytes / Q000382:microbiology*; D009035:Mothers; D009693:Nucleic Acid Hybridization; D012367:RNA, Viral / Q000032:analysis
chemical_list: D004279:DNA, Viral; D015483:HIV Antibodies; D012367:RNA, Viral