[Effectiveness of correcting radiation injuries of the thymic endocrine function by T-activin in conditions of reduced postradiation hypercorticism reaction].
T-activin administered to rats after exposure to whole-body 1.5 Gy neutron- and 6 Gy X-radiation increases considerably the thymosin-like serum activity, accelerates cellularity restoration in the thymus and spleen, but does not influence the survival rate. Ionol administered prior to X-irradiation reduces the postirradiation hypercorticism reaction and the indirect effect of radiation on lymphoid organs which it is responsible for. The combined injection of ionol and T-activin increases the thymosin-like serum activity and spleen cellularity to the highest possible level and increases the survival rate of rats from 24 to 64 per cent and the lifespan up to 6 days.
Baraboĭ
V A
VA
Grinevich
Iu A
IuA
Martynenko
S V
SV
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000308:Adrenocortical Hyperfunction / Q000209:etiology / Q000517:prevention & control*; D000818:Animals; D002084:Butylated Hydroxytoluene / Q000008:administration & dosage / Q000494:pharmacology; D004359:Drug Therapy, Combination; D008297:Male; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000401:mortality; D051381:Rats; D013947:Thymosin / Q000097:blood; D013949:Thymus Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013950:Thymus Gland / Q000187:drug effects* / Q000528:radiation effects*; D013997:Time Factors; D014916:Whole-Body Irradiation
D000276:Adjuvants, Immunologic; D010455:Peptides; D013949:Thymus Extracts; D002084:Butylated Hydroxytoluene; D013947:Thymosin; C036191:T-activin
Effektivnost' korrektsii luchevykh narusheniĭ éndokrinnoĭ funktsii timusa taktivinom v usloviiakh oslableniia reaktsii postradiatsionnogo giperkortitsizma.