[Cellular DNA determination and its significance in the identification of tumor recurrences, metastases and second primary tumors].
The DNA content of 30 malignant tumors and their metastases were compared. The DNA indices of tumors (expressed by the mean DNA content of G0.1-phase tumor cells and leukocytes) differ from each other, but in metastases they are almost the same with the values of primary tumors. It can also be observed, if a tumor consisted of more than one subpopulation of tumor cells, the metastatic potential of clones can be different. However, there is no significant relationship between the degree of ploidy and the occurrence of metastasis. The stability of DNA index in tumors and their metastases were used to distinguish two primary tumors even if their histological patterns were very similar. We present an example of the above mentioned phenomena in which the results of DNA analysis is supported by the results of mucin histochemistry and the follow up data.
Szentirmay
Z
Z
Országos Onkológiai Intézet, Budapest.
Udvarhelyi
N
N
Besznyák
I
I
D004273:DNA, Neoplasm / Q000032:analysis*; D003937:Diagnosis, Differential; D006651:Histocytochemistry; D006801:Humans; D009362:Neoplasm Metastasis / Q000175:diagnosis* / Q000473:pathology; D009369:Neoplasms / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000473:pathology
D004273:DNA, Neoplasm
A sejtenkénti DNS tartalom meghatározásának jelentösége daganat recidívák, metastasisok, illetve második primer tumorok azonosításában.