title: [Study of serum kinetics of vancomycin during the "antibiotic-lock" technique].
abstract: The serum kinetics of vancomycin was studied in two patients aged 3 and 15 years during antibiotic therapy for catheter related sepsis associated with Staphylococcus epidermidis. Vancomycin was administered, simultaneously, by parenteral conventional doses (30 mg/kg/day div q 8 h) and using the antibiotic-lock technique in the infected catheter at a high concentration (150 mg/ml) during one hour, 3 hours after each infusion. Pharmacokinetics data did not show any significant change in the serum kinetics of the antibiotic. The results suggest that delivering a high concentration of vancomycin in the infected catheter using the lock technique may be useful to sterilize infected catheter without toxic effect.
authors.affiliation: Service de Chimiothérapie Massive et Greffe de Moelle, Hôpital Nord, St-Priest-en-Jarez.
authors.forename: J C
authors.initials: JC
authors.lastname: Elian
authors.forename: D
authors.initials: D
authors.lastname: Frappaz
authors.forename: A
authors.initials: A
authors.lastname: Ros
authors.forename: J P
authors.initials: JP
authors.lastname: Gay
authors.forename: D
authors.initials: D
authors.lastname: Guichard
authors.forename: G
authors.initials: G
authors.lastname: Dorche
authors.forename: G
authors.initials: G
authors.lastname: Aubert
authors.forename: M
authors.initials: M
authors.lastname: Bouteille
authors.forename: M
authors.initials: M
authors.lastname: Ollagnier
authors.forename: F
authors.initials: F
authors.lastname: Freycon
mesh_terms: D000293:Adolescent; D016470:Bacteremia / Q000188:drug therapy / Q000209:etiology; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002675:Child, Preschool; D006801:Humans; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000209:etiology; D013212:Staphylococcus epidermidis; D013530:Surgical Wound Infection / Q000188:drug therapy / Q000209:etiology; D014640:Vancomycin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D014640:Vancomycin
vernacular_title: Etude de la cinétique sérique de la vancomycine au décours de la technique de "blocage in situ".