[Gingival hyperplasia secondary to the use of calcium antagonists: analysis].
Calcium antagonists are drugs restricting transmembrane calcium delivery. They possess a wide range of action against vasoconstriction and spastic reactions and were therefore initially recommended for the treatment of angina pectoris. With the increasing number and classes of calcium antagonists new therapeutic indications have emerged. Cases of gingival hyperplasia associated with their use are repeatedly reported, therefore the question deserves to be restated. The aim of the present study was to discuss the clinical, pathologic and pathogenetic features bases on an investigation carried out in a Department of Cardiology, on a case observation and on review of published cases in the international literature.
Sauget
P
P
Laboratoire de Pathobiologie Orale, Faculté de Chirurgie-Dentaire, Université de Nice, Sophia Antipolis, France.
Monteil
R A
RA
Morand
P
P
Loubiere
R
R
Lapalus
P
P
Haudebourg
C
C
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004110:Diltiazem / Q000009:adverse effects*; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D005881:Gingiva / Q000187:drug effects / Q000473:pathology; D005885:Gingival Hyperplasia / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000009:adverse effects*
D004110:Diltiazem; D009543:Nifedipine
Les hyperplasies gingivales secondaires à la prise d'antagonistes calciques: mise au point.