Cis and trans mechanisms of DNA repair.
DNA repair is essential for genetic stability and variability. Remarkable advances in the understanding of DNA repair by the molecular analysis of the substrate (gene repair) or the enzyme (repair genes), emphasize evolutionary conservation. Recent progress also stresses the interaction(s) between DNA repair and numerous other cellular metabolic processes, including non-nuclear and/or non-genetic responses.
Vos
J M
JM
UNC Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599-7295.
D000818:Animals; D004249:DNA Damage; D004260:DNA Repair / Q000235:genetics* / Q000502:physiology; D004261:DNA Replication; D006801:Humans; D008957:Models, Genetic; D011995:Recombination, Genetic; D014158:Transcription, Genetic