title: Effect of adrenergic agents on hematopoiesis after syngeneic bone marrow transplantation in mice.
abstract: We show that adrenergic agents modulate hematopoietic reconstitution after syngeneic bone marrow transplantation (BMT) in mice. Chemical sympathectomy by 6-hydroxydopamine (6-OHDA) significantly increased the number of peripheral blood leukocytes after syngeneic BMT. The alpha 1-adrenergic antagonist prazosin mimicked and extended the effect of 6-OHDA, with an additional rapid and significant increase of platelets, marrow granulocyte-macrophage colony-forming units, and nucleated spleen cells. Differential leukocyte counts and spleen histology from prazosin-treated mice confirmed that myelopoiesis was greatly enhanced and accelerated. In contrast, the beta-adrenergic blocker propranolol abolished the prazosin-induced increase of platelets. The detailed mechanisms by which prazosin exerts these interesting effects remain to be elucidated.
authors.affiliation: Lab for Experimental Pathology, Istituto Cantonale di Patologia, Locarno, Switzerland.
authors.forename: G J
authors.initials: GJ
authors.lastname: Maestroni
authors.forename: A
authors.initials: A
authors.lastname: Conti
authors.forename: E
authors.initials: E
authors.lastname: Pedrinis
mesh_terms: D000818:Animals; D016026:Bone Marrow Transplantation; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D011224:Prazosin / Q000494:pharmacology*; D011941:Receptors, Adrenergic / Q000502:physiology; D013563:Sympathectomy, Chemical
chemical_list: D011941:Receptors, Adrenergic; D011224:Prazosin