[Effect of short-term use of omega-3-type polyunsaturated fatty acids in subjects with hypertriglyceridemia].
OBJECTIVE
To study the effect of omega-3 polyunsaturated fatty acid supplementation on lipid profile in hypertriglyceridaemic patients.


METHODS
General practice.


METHODS
Prospective, double blind study of 12 weeks' duration.


METHODS
Eight patients received fish oil (1800 mg C20: 5 omega-3 eicosapentaenoic acid (EPA) and 1200 mg C22:6 omega-3 docosahexaenoic acid (DHA). Nine patients received corn oil (3000 mg C18: 2 omega-6 linoleic acid daily).


RESULTS
Lipid profile analysis showed a decrease in triglyceride levels after fish oil supplementation. An unexpected and unexplained finding was the rise in total cholesterol and LDH cholesterol with corn oil supplementation.


CONCLUSIONS
Fish oil causes a decrease in triglyceride levels in hypertriglyceridaemic patients.
Naber
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Afd. Inwendige Geneeskunde, Academisch Ziekenhuis Vrije Universiteit, Amsterdam.
Oudkerk Pool
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D000328:Adult; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D005395:Fish Oils / Q000627:therapeutic use*; D006801:Humans; D015228:Hypertriglyceridemia / Q000188:drug therapy*; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014280:Triglycerides / Q000097:blood
D008078:Cholesterol, LDL; D005395:Fish Oils; D008041:Linoleic Acids; D014280:Triglycerides; D002784:Cholesterol; D019787:Linoleic Acid
Effecten van kortdurend gebruik van meervoudig onverzadigde vetzuren van het omega-3-type bij personen met hypertriglyceridemie.