Effect of antimicrobials on cholesterol synthesis and content in liver and small intestines.
The antimicrobials tetracycline, ampicillin and bactrim (cotrimoxazole) decreased HMG CoA reductase activity in liver and small intestines of albino rats. Diminished incorporation of 1, 2, 14C acetate into cholesterol of small intestines in bactrim group was noted. There was a significant fall in cholesterol content of liver, duodenum, jejunum and ileum of the bactrim group and jejunum only in tetracycline group.
Pugalendhi
K V
KV
Department of Biochemistry, Rajah Muthiah Medical College & Hospital, Annamalai University, Annamalainagar, India.
Sudhakaran
P R
PR
Ramakrishnan
S
S
D000667:Ampicillin / Q000494:pharmacology*; D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis*; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D007421:Intestine, Small / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D013752:Tetracycline / Q000494:pharmacology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology*
D000667:Ampicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases; D013752:Tetracycline