Prevalence of hereditary ataxias and spastic paraplegias in Molise, a region of Italy.
An epidemiological survey of hereditary ataxias and paraplegias was conducted in Molise, a region of Italy (335, 211 inhabitants on 1 January 1989). Total prevalence was 7.5 x 10(-5) inhabitants (95% confidence limits 4.8-11.1). There were 7 patients with Friedreich's disease, 5 with early onset cerebellar ataxia with retained tendon reflexes, 4 with ataxia-telangiectasia, 9 with hereditary spastic paraplegias (2 autosomal dominant and 7 autosomal recessive cases). There was no patient with autosomal dominant cerebellar ataxia.
Filla
A
A
Department of Neurology, Second School of Medicine, University of Naples, Italy.
De Michele
G
G
Marconi
R
R
Bucci
L
L
Carillo
C
C
Castellano
A E
AE
Iorio
L
L
Kniahynicki
C
C
Rossi
F
F
Campanella
G
G
D000293:Adolescent; D000328:Adult; D001259:Ataxia / Q000145:classification / Q000453:epidemiology* / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010264:Paraplegia / Q000145:classification / Q000453:epidemiology* / Q000235:genetics; D015995:Prevalence