Effect of cisplatin on lipid peroxidation in pig blood platelets.
The effect of cisplatin (cis-diamminedichloroplatinum II) on the activities of the blood platelet antioxidative enzymes (glutathione peroxidase, superoxide dismutase) as well as on the peroxidation of blood platelet lipids was investigated. Cisplatin was found to cause a significant inhibition of platelet free radical scavering enzyme activity and an increase of malonyldialdehyde levels in blood platelets incubated with cisplatin in vitro.
Wachowicz
B
B
Department of Biochemistry, University of Lódź, Poland.
Kustroń
J
J
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology*; D002945:Cisplatin / Q000494:pharmacology*; D007700:Kinetics; D015227:Lipid Peroxidation / Q000187:drug effects*; D008315:Malondialdehyde / Q000378:metabolism; D013552:Swine
D008315:Malondialdehyde; D002945:Cisplatin