title: The effect of an experimental mouthrinse on enamel lesion remineralization in vitro.
abstract: This paper describes the effect of a 2 ppm fluoride containing, slightly acidic mouthrinse (pH = 6) on the remineralization of enamel lesions in vitro. The rinse was applied twice daily for 2 min, on about 85 microns in depth artificial lesions. Artificial enamel lesions were formed at pH = 5 in a 6% CMC gel. The lesions were subsequently remineralized in vitro in a neutral remineralizing solution (1.5 mM Ca and 0.9 mM phosphate) with or without the application of the rinse. After 3 weeks the samples were evaluated by means of quantitative microradiography. The results showed that a statistically significant reduction in lesion depth occurred of 48 and 29% with or without rinse application, with respect to the original lesion depth. The effect of the rinse compared with no rinse decreased the lesion depth by 40%. The data indicate that application of a slightly acidic rinse with 2 ppm fluoride applied twice a day, stimulates the remineralization at the lesion front and does not lead to blocking of enamel pores observed after acidic, high level F applications (APF).
authors.affiliation: Laboratory for Materia Technica, University of Groningen, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Arends
authors.forename: J
authors.initials: J
authors.lastname: de Vries
authors.forename: J
authors.initials: J
authors.lastname: Ruben
mesh_terms: D000818:Animals; D002021:Buffers; D002122:Calcium Chloride / Q000008:administration & dosage / Q000494:pharmacology; D002417:Cattle; D003743:Dental Enamel / Q000737:chemistry / Q000187:drug effects*; D005459:Fluorides / Q000008:administration & dosage / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D008903:Minerals / Q000032:analysis; D009067:Mouthwashes; D010710:Phosphates / Q000008:administration & dosage / Q000494:pharmacology; D011188:Potassium / Q000008:administration & dosage / Q000494:pharmacology; D017680:Potassium Compounds; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000494:pharmacology; D017001:Tooth Demineralization / Q000378:metabolism / Q000503:physiopathology*; D014089:Tooth Remineralization
chemical_list: D002021:Buffers; D008903:Minerals; D009067:Mouthwashes; D010710:Phosphates; D017680:Potassium Compounds; D012969:Sodium Fluoride; C013216:potassium phosphate; D002122:Calcium Chloride; D005459:Fluorides; D011188:Potassium