External gamma-ray counting of selected tissues from a Thorotrast patient.
Results of gamma-ray measurements of selected tissues from a patient who was injected with Thorotrast almost 36 y ago are reported. The purposes of this study were: 1) to determine the relative tissue distribution and activities of specific radionuclides in the 232Th decay chain, specifically 228Ra (as measured by 228Ac), 212Pb, and 224Ra (measured directly and as measured by 212Pb), and 2) to evaluate the level of radioactive disequilibrium among the daughter products. The spleen and liver had the highest concentrations of radioactivity. Bone also appears to be a long-term sink for 232Th daughter products based on estimates from a small portion of one rib. Larynx and esophagus contained measurable activity, which may have been due to their proximity to the "Thorotrastoma." Radioactivity in the remaining measured tissues were low, as expected. Secular equilibrium could be demonstrated in bone, pancreas, larynx, esophagus, and breast. Significant disequilibrium was observed for spleen, liver, kidney, and red blood cells. Radioactivity measurements reported here will be useful in estimating radiation doses to selected tissues. Such dose estimates are valuable in refining current risk estimates (e.g., liver) and in identifying tissues at risk for further epidemiologic studies. These results, while consistent with other published studies, should be interpreted with caution since measurements were made on only one patient.
Mays
C W
CW
National Cancer Institute, National Institutes of Health, Rockville, MD 20892.
Aamodt
R L
RL
Inn
K G
KG
Brown
D R
DR
Greenberg
R R
RR
Iyengar
V G
VG
Schima
F J
FJ
Slaback
L S
LS
Tracy
J W
JW
Lynch
T P
TP
D000368:Aged; D001842:Bone and Bones / Q000378:metabolism; D003287:Contrast Media; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism; D011851:Radioactivity; D013154:Spleen / Q000378:metabolism; D013911:Thorium Dioxide / Q000493:pharmacokinetics*; D013997:Time Factors; D014018:Tissue Distribution
D003287:Contrast Media; D013911:Thorium Dioxide