Probing the molecular basis of resistance to pyrimethamine by site-directed mutagenesis.
Wagner
C R
CR
Department of Chemistry, Pennsylvania State University, University Park 16802.
Benkovic
S J
SJ
D000818:Animals; D001665:Binding Sites; D004351:Drug Resistance / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology / Q000235:genetics; D005493:Folic Acid Antagonists; D007700:Kinetics; D016297:Mutagenesis, Site-Directed; D010961:Plasmodium / Q000187:drug effects / Q000201:enzymology / Q000235:genetics; D011739:Pyrimethamine / Q000494:pharmacology*; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics*; D013816:Thermodynamics
D005493:Folic Acid Antagonists; D013762:Tetrahydrofolate Dehydrogenase; D011739:Pyrimethamine