Noncompressive spinal radiculitis.
Sciatica can be caused by a herniated disc (compressive neuropathy) or by the process of disc degeneration (noncompressive neuropathy). Laminectomy and discectomy usually produce a good result in compressive neuropathy, whereas surgery for noncompressive neuropathy, if necessary, consists of complete excision of the disc and anterior interbody fusion, posterior fusion, or both. Noncompressive spinal radiculitis is a biochemical, not a biomechanical, problem. Phospholipase A2, substance P, and increased fibrinolytic activity have been implicated in the process.
Sella
E J
EJ
Department of Orthopaedics and Rehabilitation, Yale University, New Haven, Connecticut.
D015551:Autoimmunity; D001696:Biomechanical Phenomena; D006801:Humans; D007403:Intervertebral Disc / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D011843:Radiculopathy / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D013122:Spinal Diseases / Q000150:complications* / Q000628:therapy