title: [Antipyretic effects of traditional Chinese medicines in bacterial endotoxin-induced febrile rabbits].
abstract: The antipyretic effects of oral administration of eight traditional Chinese medicines (dried extracts) were tested in febrile rabbits injected with bacterial pyrogen, lipopolysaccharide (LPS) 0.05 micrograms/kg (i.v.). The traditional Chinese medicines were given 0.6-2 g/10 ml/kg (p.o.) simultaneously with LPS. The most potent antipyretic effect was observed in Dai-jyoki-to (Ta-chen-chi-tang). The moderate antipyretic effects were observed in Toki-syakuyaku-san (Tang-kuei-shao-yao-san) and Syo-saiko-to (Hssiao-chai-hu-tang). Koso-san (Hsiang-su-san), Oren-gedoku-to (Huang-lien-chieh-tu-tan), Gorei-san (Wu-ling-san), Kakkon-to (Ko-ken-tang) and Byakkoka-ninjin-to (Pai-hu-chia-jen-sheng-tang) showed no effects.
authors.affiliation: National Institute of Hygienic Sciences, Osaka Branch, Chuo-ku, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Itami
authors.forename: M
authors.initials: M
authors.lastname: Ema
authors.forename: J
authors.initials: J
authors.lastname: Sakamoto
authors.forename: K
authors.initials: K
authors.lastname: Hosoda
authors.forename: M
authors.initials: M
authors.lastname: Noguchi
authors.forename: H
authors.initials: H
authors.lastname: Kawasaki
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005334:Fever / Q000139:chemically induced / Q000188:drug therapy*; D008070:Lipopolysaccharides; D008297:Male; D011817:Rabbits
chemical_list: D004365:Drugs, Chinese Herbal; D008070:Lipopolysaccharides