title: Colostral transfer of Bacteroides nodosus antibodies in sheep.
abstract: Ovine contagious foot rot may cause lameness in sheep, resulting in decreased wool growth and low weight gain. Affected neonatal lambs are difficult to treat, and treatment is labor intensive; thus, a method of prevention is warranted. Vaccination of ewes with a multivalent vaccine in an oil adjuvant induced development of antibody to the somatic O antigen of Bacteroides nodosus, and this antibody was detected in serum of newborn lambs after consumption of colostrum from the vaccinated ewes. Antibody titers were determined in 48 unvaccinated ewe/lamb pairs, and in 50 once-vaccinated and 78 twice-vaccinated pairs. Serum and colostrum O-agglutinin titers to B nodosus were determined by a microtitration agglutination test. Lambs from vaccinated ewes had significantly (P less than 0.05) higher O-agglutinin titers than those from unvaccinated ewes, and double vaccination of ewes resulted in the highest potentially protective titers (greater than 1:2,400) in ewes and lambs.
authors.affiliation: Department of Reproduction, School of Veterinary Medicine, University of California, Davis 95616.
authors.forename: P A
authors.initials: PA
authors.lastname: Bartram
authors.forename: J S
authors.initials: JS
authors.lastname: Glenn
authors.forename: L L
authors.initials: LL
authors.lastname: Lasslo
mesh_terms: D000372:Agglutination Tests; D000818:Animals; D000831:Animals, Newborn; D000907:Antibodies, Bacterial / Q000032:analysis / Q000097:blood; D001428:Bacterial Vaccines; D001439:Bacteroides / Q000276:immunology*; D003126:Colostrum / Q000276:immunology; D005260:Female; D005535:Foot Rot / Q000276:immunology* / Q000517:prevention & control; D007112:Immunity, Maternally-Acquired; D007136:Immunoglobulins / Q000032:analysis / Q000097:blood; D011247:Pregnancy; D012044:Regression Analysis; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology* / Q000517:prevention & control; D014611:Vaccination / Q000379:methods / Q000662:veterinary
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D007136:Immunoglobulins