title: In vivo complement activation and binding of C3 to encapsulated Cryptococcus neoformans.
abstract: Tissues from mice infected with Cryptococcus neoformans were examined by immunofluorescence to determine the extent of deposition of complement component C3 on encapsulated cryptococci. The relative percentages of cryptococci in each tissue having readily visible C3 were greatest for liver and lung tissues, with the kidney tissue having the next highest percentage and the spleen having the lowest percentage. Binding of C3 fragments to cryptococci in brain tissue was essentially absent.
authors.affiliation: Department of Microbiology, University of Nevada, Reno 89557.
authors.forename: K
authors.initials: K
authors.lastname: Truelsen
authors.forename: T
authors.initials: T
authors.lastname: Young
authors.forename: T R
authors.initials: TR
authors.lastname: Kozel
mesh_terms: D000818:Animals; D003167:Complement Activation; D003176:Complement C3 / Q000378:metabolism*; D003455:Cryptococcus neoformans / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C
chemical_list: D003176:Complement C3