Haplotype analysis and polymorphic frequency data at two factor IX loci (F9-192 and F9-Hha1) in a Chinese population.
Gene frequencies and haplotypes for two factor IX markers, F9-192 and F9-Hha1, were determined in a Chinese population. The frequencies for F9-192 are 0.86 for A and 0.14 for G. For F9-Hha1, the gene frequencies are 0.69 for - and 0.31 for +. Haplotype analysis revealed that the two polymorphic sites are in linkage equilibrium and, thus, are useful markers for genetic counseling of Asian families in which hemophilia B exists.
Chen
S H
SH
Department of Pediatrics, University of Washington, Seattle 98195.
Wang
N S
NS
Schoof
J
J
Scott
C R
CR
D000483:Alleles; D001483:Base Sequence; D002681:China / Q000208:ethnology; D002874:Chromosome Mapping; D005164:Factor IX / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic / Q000235:genetics*
D005819:Genetic Markers; D005164:Factor IX