Comparative study of the effects of beta-sitosterol, estradiol and progesterone on selected biochemical parameters of the uterus of ovariectomised rats.
A comparative study was made of the effects of beta-sitosterol, estradiol-17 beta and progesterone, individually and in combinations, on certain biochemical parameters important to carbohydrate metabolism in the uteri of adult ovariectomised rats. beta-Sitosterol (SITO), estradiol (E2) and combined treatment (SITO + E2) induced significant increases in glycogen concentration and the activities of glucose-6-phosphate dehydrogenase (G6PDH), phosphohexose isomerase (PHI) and total lactate dehydrogenase (LDH). Progesterone (P) administration however, raised only the uterine PHI and LDH activities. Co-administration of P with beta-sitosterol (P + SITO) suppressed the SITO-induced increase in glycogen concentration and G6PDH activity. On the other hand, combined treatment (P + SITO) augmented total LDH activity.
Malini
T
T
Department of Endocrinology, Postgraduate Institute of Basic Medical Sciences, Taramani, Madras, India.
Vanithakumari
G
G
D000818:Animals; D050260:Carbohydrate Metabolism; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D005956:Glucose-6-Phosphate Isomerase / Q000187:drug effects / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000187:drug effects / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000187:drug effects / Q000378:metabolism; D010052:Ovariectomy; D010053:Ovary / Q000502:physiology*; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012855:Sitosterols / Q000494:pharmacology*; D013261:Sterols / Q000494:pharmacology; D014599:Uterus / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism
D012855:Sitosterols; D013261:Sterols; D011374:Progesterone; D004958:Estradiol; C025473:gamma-sitosterol; D006003:Glycogen; D007770:L-Lactate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D005956:Glucose-6-Phosphate Isomerase