Effects of jogging exercise on patients with the pigmentary dispersion syndrome and pigmentary glaucoma.
BACKGROUND
Exercise-induced anterior chamber pigment dispersion with intraocular pressure (IOP) elevation has been reported in patients with the pigmentary dispersion syndrome. Marked pigment dispersion with or without elevation of IOP could predispose these patients to visual field loss. The authors designed this study to evaluate the effects of jogging exercise on anterior chamber pigment and IOP in a group of patients with the pigmentary dispersion syndrome or pigmentary glaucoma.


METHODS
Fourteen subjects with the pigmentary dispersion syndrome, 10 subjects with pigmentary glaucoma, and 10 control subjects underwent a 45-minute protocol of jogging exercise. Anterior chamber pigment was graded and IOP was measured before and up to 3 hours after completion of the exercise protocol.


RESULTS
Eyes of experimental subjects were significantly more likely to develop exercise-induced pigment dispersion than were eyes of control subjects. In experimental subjects, eyes treated with pilocarpine at the time of the study were significantly less likely to develop exercise-induced pigment dispersion than eyes not treated with pilocarpine. In two experimental subjects, pre-exercise treatment with pilocarpine appeared to inhibit exercise-induced pigment dispersion.


CONCLUSIONS
The authors do not believe that all patients with the pigmentary dispersion syndrome or pigmentary glaucoma need to avoid exercise. However, for patients with these disorders who regularly engage in jogging or more strenuous or more jarring types of exercise, they suggest an evaluation before and after the type of exercise in question. If marked exercise-induced pigment dispersion occurs, pilocarpine therapy may be an alternative to avoidance of the exercise.
Haynes
W L
WL
Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City 52242.
Johnson
A T
AT
Alward
W L
WL
D000867:Anterior Chamber / Q000473:pathology; D005260:Female; D005902:Glaucoma, Open-Angle / Q000209:etiology*; D006801:Humans; D007429:Intraocular Pressure; D007499:Iris Diseases / Q000209:etiology* / Q000517:prevention & control; D007590:Jogging; D008297:Male; D010857:Pigment Epithelium of Eye / Q000473:pathology; D013577:Syndrome