Peroxide-dependent amino acid oxidation and chemiluminescence catalysed by magnesium-pyridoxal phosphate-glutamate complex.
Magnesium-pyridoxal-5'-phosphate-glutamate (MPPG) has been shown to ameliorate atherosclerotic symptoms in rabbits. In vitro, MPPG in the presence of peroxides such as cholesterolhydroperoxide or cumene hydroperoxide and Mn2+ ions produces "excited states" measurable as chemiluminescence or ethylene release from 1-aminocyclopropane-1-carboxylic acid (ACC). The reactions are stimulated synergistically by unsaturated fatty acids. Pyridoxal phosphate exhibits similar properties, but can be differentiated from the activities of MPPG or the sum of the components present in MPPG.
Meyer
B U
BU
Institut für Botanik und Mikrobiologie, Technische Universität München, Germany.
Schneider
W
W
Elstner
E F
EF
D000596:Amino Acids / Q000737:chemistry* / Q000378:metabolism; D000598:Amino Acids, Cyclic; D000818:Animals; D001161:Arteriosclerosis / Q000378:metabolism; D002784:Cholesterol / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D005030:Ethylenes / Q000032:analysis; D005973:Glutamine / Q000494:pharmacology*; D006861:Hydrogen Peroxide / Q000032:analysis* / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008163:Luminescent Measurements; D008274:Magnesium / Q000494:pharmacology; D008345:Manganese; D010084:Oxidation-Reduction; D011732:Pyridoxal Phosphate; D014439:Tyramine
D000596:Amino Acids; D000598:Amino Acids, Cyclic; D005030:Ethylenes; D000960:Hypolipidemic Agents; D005973:Glutamine; C023863:1-aminocyclopropane-1-carboxylic acid; D008345:Manganese; D011732:Pyridoxal Phosphate; C047672:magnesium-pyridoxal-5'-phosphate glutamate; C002843:cholesterol hydroperoxide; C036216:ethylene; D002784:Cholesterol; D006861:Hydrogen Peroxide; D008274:Magnesium; D014439:Tyramine