[Comparative analysis of mezlocillin/metronidazole and amoxicillin/clavulanic acid as "one shot" preventive antibiotic administration in colorectal interventions].
The prophylactic effect of intraoperative "one shot" antibiotic application in colorectal surgery was investigated. Patients were randomised and the antibiotic combination Mezlocillin/Metronidazole (group A) or Amoxicillin/Clavulamid acid (group B) was applicated in 160 patients. 111 patients were selected for the study (group A: 59; group B: 52 patients). In the postoperative course 53% (group A) and 67% (group B) of the patients developed bacterial infections. Abdominal wound healing was complicated by infection in 15% (A) and 12% (B) of the patients. A significant difference between the two groups could not be proven, 24% of all patients with documented intraoperative bacterial contamination and 10% of the patients with negative findings developed wound infections. In colorectal surgery patients are still at high risk for infectious complications. Applicated antibiotics should basically cover aerobic and anaerobic germs.
Löhde
E
E
Institut für Krankenhaushygiene und Mikrobiologie, 1. Chirurgische Abteilung des Krankenhauses Moabit, Berlin.
Scholz
L
L
Gemperle
A
A
Langmark
H
H
Hopfenmüller
W
W
Abri
O
O
Kraas
E
E
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000658:Amoxicillin / Q000008:administration & dosage*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000008:administration & dosage*; D003082:Colectomy; D015179:Colorectal Neoplasms / Q000601:surgery*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage*; D008802:Mezlocillin / Q000008:administration & dosage*; D008875:Middle Aged; D013530:Surgical Wound Infection / Q000517:prevention & control*
D000900:Anti-Bacterial Agents; D002969:Clavulanic Acids; D008795:Metronidazole; D019818:Clavulanic Acid; D000658:Amoxicillin; D008802:Mezlocillin
Vergleichsanalyse von Mezlozillin/Metronidazol und Amoxicillin/Clavulansäure als "one shot"-Antibiotikaprophylaxe bei kolorektalen Eingriffen.