[Multifactorial analysis of combined use of an antibiotic and peptidoglycan of microbial origin in experimental plague].
The combined effect of doxycycline and microbial peptidoglycan was studied with multifactorial analysis. The drugs were used preventively and therapeutically. The preventive use of doxycycline in the subtherapeutic doses in combination with the immunomodulator resulted in a significant increase in the survival rate rather than the average life-span (ALS) of the experimental animals. The therapeutic use of the drugs was more efficient than the preventive one and resulted in higher survival and ALS. By the results of the experiments polynomial statistic models of the second order were developed and the equal level curves characterizing the survival rate and ALS were plotted. The dose-time regimens of the combined use of doxycycline an peptidoglycan were optimized.
Nikitin
A V
AV
Makarovskaia
L N
LN
Fomina
I P
IP
Ivanitskaia
L P
LP
Popova
G O
GO
Vinidchenko
N N
NN
Korganov
Ia N
IaN
Bodunkova
L E
LE
D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004318:Doxycycline / Q000008:administration & dosage*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D051379:Mice; D010457:Peptidoglycan / Q000008:administration & dosage*; D010930:Plague / Q000188:drug therapy* / Q000401:mortality / Q000517:prevention & control; D012231:Rhizobium
D010457:Peptidoglycan; D004318:Doxycycline
Mnogofaktornyĭ analiz kombinirovannogo primeneniia antibiotika i peptidoglikana mikrobnogo proiskhozhdeniia pri éksperimental'noĭ chumnoĭ infektsii.