title: Langerhans' cell histiocytosis and the nervous system.
abstract: We report two cases of Langerhans' cell histiocytosis with unusual central nervous system (CNS) involvement. The first patient had behavioural disturbances, memory loss and diabetes insipidus. His response to a range of treatments was poor. The second patient presented with seizures and headaches suggestive of raised intracranial pressure. Etoposide (VP16) chemotherapy led to a dramatic clinical and radiological improvement. The various CNS manifestations of Langerhans' cell histiocytosis and their management are discussed.
authors.affiliation: Department of Medicine, Hammersmith Hospital, London, UK.
authors.forename: D J
authors.initials: DJ
authors.lastname: Burn
authors.forename: J D
authors.initials: JD
authors.lastname: Watson
authors.forename: M
authors.initials: M
authors.lastname: Roddie
authors.forename: A C
authors.initials: AC
authors.lastname: Chu
authors.forename: N J
authors.initials: NJ
authors.lastname: Legg
authors.forename: R S
authors.initials: RS
authors.lastname: Frackowiak
mesh_terms: D000328:Adult; D002493:Central Nervous System Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008297:Male; D014057:Tomography, X-Ray Computed