Interferon-gamma in cerebrospinal fluid without pleocytosis in scrub typhus.
We detected immunoreactive interferon-gamma (IFN-gamma) both in cerebrospinal fluid (CSF) and in serum of 5 patients with scrub typhus, one with meningitis and 4 other cases with neither CSF pleocytosis nor blood-CSF barrier dysfunction. Our data suggest intrathecal synthesis of IFN-gamma without pleocytosis which implies occult cerebral involvement in scrub typhus.
Ikeda
M
M
Department of Neurology, Asahi General Hospital, Chiba, Japan.
Yoshida
S
S
Tsukagoshi
H
H
D000328:Adult; D000368:Aged; D001812:Blood-Brain Barrier; D002555:Cerebrospinal Fluid / Q000166:cytology; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis* / Q000096:biosynthesis; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis / Q000134:cerebrospinal fluid*; D008578:Meninges / Q000378:metabolism; D008581:Meningitis / Q000134:cerebrospinal fluid; D008875:Middle Aged; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid; D012612:Scrub Typhus / Q000134:cerebrospinal fluid* / Q000503:physiopathology
D002556:Cerebrospinal Fluid Proteins; D007371:Interferon-gamma