[Antibodies against neutrophil cytoplasm. A new group of autoantibodies].
Antibodies against cytoplasmic antigens of neutrophils are a recently described group of autoantibodies associated with some types of primary systemic vasculitis and necrotizing glomerulonephritis. In clinical practice they are a useful laboratory examination which helps with the diagnosis of this group of diseases and to follow up their activity and response to treatment. The existence of ANCA implies also a new aspect of classification of vasculitis. The autoimmune reaction of ANCA with lysosomal enzymes is also another possible mechanism of development of tissue damage. The submitted paper is a review of literature on the importance of ANCA from the practical as well as theoretical aspect.
Bartůnková
J
J
Oddĕlení klinické imunologie 1. lékarské fakulty KU, Praha.
D001323:Autoantibodies / Q000032:analysis; D015415:Biomarkers; D003593:Cytoplasm / Q000276:immunology*; D006801:Humans; D009504:Neutrophils / Q000276:immunology*
D001323:Autoantibodies; D015415:Biomarkers
Protilátky proti cytoplazmĕ neutrofilů. Nová skupina autoprotilátek.