title: Intracerebral transplants of primary muscle cells: a potential 'platform' for transgene expression in the brain.
abstract: After the transplantation of rat primary muscle cells into the caudate or cortex of recipient rats, the muscle cells were able to persist for at least 6 months. Muscle cells transfected with expression plasmids prior to transplantation were able to express reporter genes in the brains for at least 2 months. These results suggest that muscle cells might be a useful 'platform' for transgene expression in the brain.
authors.affiliation: Department of Pediatrics and Medical Genetics, Waisman Center, University of Wisconsin, Madison 53706.
authors.forename: S
authors.initials: S
authors.lastname: Jiao
authors.forename: E
authors.initials: E
authors.lastname: Schultz
authors.forename: J A
authors.initials: JA
authors.lastname: Wolff
mesh_terms: D000818:Animals; D002421:Caudate Nucleus; D002470:Cell Survival / Q000235:genetics; D002540:Cerebral Cortex; D015870:Gene Expression / Q000235:genetics*; D009132:Muscles / Q000637:transplantation*; D010957:Plasmids / Q000235:genetics; D051381:Rats; D011917:Rats, Inbred Lew; D033581:Stem Cell Transplantation; D014162:Transfection; D016042:Transplantation, Heterotopic / Q000502:physiology*