title: Intraventricular rifampicin in severe tuberculous meningo-encephalitis.
abstract: We present a patient acutely ill from severe tuberculous meningo-encephalitis, in whom acute hepatic and renal failure, due to intercurrent septic shock, precluded the administration of full systemic dosage of antituberculous drugs. Daily direct intraventricular administration of 5 mg rifampicin, via a subcutaneous Ommaya reservoir connected to a catheter placed in the right lateral cerebral ventricle, resulted in rapid improvement without neurological sequelae. Intraventricular rifampicin administration for 50 consecutive days was well-tolerated without local or systemic side-effects. In well-selected patients with severe tuberculous meningo-encephalitis, intraventricular rifampicin may safely and highly effectively be added to systemic antituberculous therapy.
authors.affiliation: Dept. of Pneumology, Academic Hospital, University of Brussels, Belgium.
authors.forename: W
authors.initials: W
authors.lastname: Vincken
authors.forename: M
authors.initials: M
authors.lastname: Meysman
authors.forename: D
authors.initials: D
authors.lastname: Verbeelen
authors.forename: S
authors.initials: S
authors.lastname: Lauwers
authors.forename: J
authors.initials: J
authors.lastname: D'Haens
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications; D002408:Catheters, Indwelling; D002552:Cerebral Ventricles; D006801:Humans; D015918:Infusion Pumps, Implantable; D008107:Liver Diseases / Q000150:complications; D008297:Male; D008590:Meningoencephalitis / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D012293:Rifampin / Q000008:administration & dosage* / Q000627:therapeutic use; D012772:Shock, Septic / Q000150:complications; D014390:Tuberculosis, Meningeal / Q000150:complications / Q000188:drug therapy*
chemical_list: D012293:Rifampin