title: Naturally occurring Mycobacterium scrofulaceum infection in a laboratory mouse colony.
abstract: A contamination with Mycobacterium scrofulaceum was experienced in a colony of BALB/c-nu/nu mice. The contamination was noticed after introduction of C57BL/6 and C57BL/6. Lyt l. 1 strains into facilities that kept the colony. M. scrofulaceum seemed to be spread by oral infestation and cross-contamination of fecal excretions during handling of the mice. The organisms were shed continually or intermittently into feces of weaned nu/+ and nu/nu mice of BALB/c background, and were isolated from the mesenteric lymph nodes and spleen of some of the mice. Some of the bacillus-carrying mice developed serum antibody to M. scrofulaceum of IgG and IgA classes and gave a low degree of hypersensitivity to PPD from M. tuberculosis.
authors.affiliation: Department of Veterinary Pathology, Faculty of Agriculture, Gifu University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ueda
authors.forename: S
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Ohtsuka
authors.forename: K
authors.initials: K
authors.lastname: Machii
authors.forename: S
authors.initials: S
authors.lastname: Yamazaki
authors.forename: H
authors.initials: H
authors.lastname: Saito
mesh_terms: D000818:Animals; D000830:Animals, Laboratory / Q000276:immunology / Q000382:microbiology*; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D005243:Feces / Q000382:microbiology; D005260:Female; D007070:Immunoglobulin A / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D008198:Lymph Nodes / Q000382:microbiology; D008297:Male; D008643:Mesentery; D051379:Mice / Q000382:microbiology*; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009165:Mycobacterium Infections, Nontuberculous / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D015359:Mycobacterium scrofulaceum / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity; D012376:Rodent Diseases / Q000276:immunology / Q000382:microbiology*
chemical_list: D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G