title: Effects of prostaglandin E2 on the fluctuating hearing loss in Ménière's disease.
abstract: To elucidate the possible mediating role of prostaglandins as underlying mechanism of the acute audiologic effects of furosemide in patients with Ménière's disease, the hearing threshold shift after a 1 hour infusion of a commercially available prostaglandin E2 derivative (120 ng/kg body weight) was determined in 10 patients. Prostaglandin E2 produced a transient hearing improvement comparable to the effects obtained in the furosemide test with 1.2 mg/kg bw in the same patients. The effectiveness of a prostaglandin infusion on hearing levels may be a further sign of the involvement of this mediator in hearing processes.
authors.affiliation: Universitäts-HNO-Klinik, Köln, Germany.
authors.forename: O
authors.initials: O
authors.lastname: Michel
authors.forename: R
authors.initials: R
authors.lastname: Matthias
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold / Q000187:drug effects*; D015232:Dinoprostone / Q000494:pharmacology*; D005260:Female; D005665:Furosemide / Q000494:pharmacology*; D005990:Glycerol / Q000494:pharmacology; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000150:complications*; D008875:Middle Aged; D010865:Pilot Projects
chemical_list: D005665:Furosemide; D015232:Dinoprostone; D005990:Glycerol