Ranitidine treatment and cortisol metabolism in man.
Experimental evidence suggested that H2-receptor antagonists may inhibit not only hepatic but also adrenal cytochrome P-450 dependent monooxygenases. Therefore, the effects of ranitidine (150 mg b.i.d. over 14 days) on cortisol metabolism and antipyrine clearance have been investigated in nine healthy volunteers. Urinary excretion of 6 beta-hydroxycortisol (6 beta-OHC) and 17-hydroxycorticosteroids (17-OHCS) remained unaffected by ranitidine pretreatment, as did the calculated 6 beta-OHC/17-OHCS ratio. Only marginal effects were observed on antipyrine kinetics and metabolite formation. We conclude that neither adrenal production of corticosteroids nor their hepatic metabolism is affected by ranitidine administration.
Mönig
H
H
1. Medizinische Klinik der Christian-Albrechts-Universität, Kiel, Germany.
Hoffmann
K
K
Ohnhaus
E E
EE
Schulte
H M
HM
D015065:17-Hydroxycorticosteroids / Q000652:urine; D000328:Adult; D000983:Antipyrine / Q000493:pharmacokinetics; D001711:Biotransformation / Q000187:drug effects; D006801:Humans; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine; D008297:Male; D011899:Ranitidine / Q000494:pharmacology*
D015065:17-Hydroxycorticosteroids; C001380:6 beta-hydroxycortisol; D011899:Ranitidine; D000983:Antipyrine; D006854:Hydrocortisone