Comparison of the cardiotoxicity of ethanol in women versus men.
Subclinical left ventricular (LV) dysfunction is a common occurrence in alcoholic men but has been claimed to be absent or very rare in alcoholic women. M-mode echocardiography was performed to study LV size, mass and systolic function, and Doppler ultrasound to study LV filling in 14 chronic female alcoholics aged 24 to 48 years and in 2 age-matched control groups consisting of 17 healthy women and 22 alcoholic men. Compared with healthy women, female alcoholics had no differences in heart rate or blood pressure but a shorter LV end-diastolic diameter (mean +/- standard deviation, 46 +/- 4 vs 48 +/- 3 mm, p less than 0.05), lower fractional shortening (31 +/- 6 vs 34 +/- 3%, p less than 0.05), increased wall thickness to radius ratio (0.43 +/- 0.08 vs 0.37 +/- 0.05, p less than 0.05), reduced peak early diastolic transmitral velocity (45 +/- 11 vs 68 +/- 7 cm/s, p less than 0.001), reduced deceleration of the early diastolic velocity (-274 +/- 69 vs -572 +/- 107 cm/s2, p less than 0.001), and an increased atrial filling fraction (35 +/- 12 vs 27 +/- 5%, p less than 0.05). Although alcoholic men had a longer duration of heavy drinking than alcoholic women (median 19 vs 5 years, p less than 0.001), and a higher systolic blood pressure (140 +/- 17 vs 120 +/- 17 mm Hg, p less than 0.001), there were no statistically significant differences between the sexes either in LV diameters, wall thickness or mass normalized to body area, or in indexes of systolic or diastolic LV function.(ABSTRACT TRUNCATED AT 250 WORDS)
Kupari
M
M
First Department of Medicine, Helsinki University Central Hospital, Finland.
Koskinen
P
P
D000328:Adult; D002310:Cardiomyopathy, Alcoholic / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000503:physiopathology; D004452:Echocardiography; D000431:Ethanol / Q000009:adverse effects*; D005260:Female; D006321:Heart / Q000187:drug effects; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008297:Male; D012307:Risk Factors; D012737:Sex Factors; D016277:Ventricular Function, Left / Q000502:physiology*
D000431:Ethanol