[Immunologic behavior of human tracheal transplants].
In this study we tried to investigate the antigenicity of human tracheal allografts. We found transplantation antigens in the mucosa and the mixed glands using monoclonal antibodies in an indirect immunoperoxidase method. However these antigens were able to be destroyed with a chemical preservation procedure. The diminution of the antigenicity could be also achieved in a tracheal transplant human recipient. These results show that the preserved trachea may be immunologically a suitable material for reconstruction in surgery of the trachea.
Bujía
J
J
Klinik und Poliklinik für Hals-Nasen-Ohrenkranke, Ludwig-Maximilians-Universität München.
Wilmes
E
E
Hammer
C
C
D000368:Aged; D000911:Antibodies, Monoclonal; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D007124:Immunoenzyme Techniques; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000276:immunology*; D014021:Tissue Preservation; D014132:Trachea / Q000276:immunology / Q000637:transplantation*; D014135:Tracheal Stenosis / Q000276:immunology / Q000601:surgery*
D000911:Antibodies, Monoclonal; D000949:Histocompatibility Antigens Class II
Immunologisches Verhalten menschlicher Trachealtransplantate.