Effects of switching from a high-fat diet to a low-fat diet on tumor proliferation and cell kinetics of 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in rats.
We investigated the stimulatory effect of a high-fat diet on tumorigenesis, tumor proliferation and cell kinetics of 7,12-dimethylbenz(a)anthracene-induced mammary carcinomas in Sprague-Dawley rats, and sought to determine whether switching the animals from a high-fat diet to a low-fat diet would suppress tumor proliferation and cell kinetics. The high-fat diet significantly stimulated tumorigenesis, tumor proliferation and cell kinetics. After the animals were switched from the high-fat diet to the low-fat diet, however, tumor growth decreased, the BrdUrd labeling indices of tumors significantly decreased, and the potential doubling times of tumors significantly increased. Therefore, switching from a high-fat diet to a low-fat diet may improve the prognosis of breast cancer.
Noguchi
M
M
Department of Surgery (II), School of Medicine, Kanazawa University, Japan.
Ohta
N
N
Kitagawa
H
H
Earashi
M
M
Thomas
M
M
Miyazaki
I
I
Mizukami
Y
Y
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001835:Body Weight / Q000502:physiology; D001973:Bromodeoxyuridine / Q000378:metabolism; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004041:Dietary Fats / Q000008:administration & dosage*; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000178:diet therapy* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains
D004273:DNA, Neoplasm; D004041:Dietary Fats; D015127:9,10-Dimethyl-1,2-benzanthracene; D001973:Bromodeoxyuridine