Chronobiologic response modifiers and breast cancer development: classical background and chronobiologic tasks remaining.
Mapping the chronome's multi-frequency (about-daily, -weekly, and -yearly) neuroendocrine and immune rhythms can help determine when potential chronobiologic response modifiers (CBRMs) should be applied. Aimed at shielding in time by manipulating rhythms, CBRMs may be pertinent to all stages of carcinogenesis, from prevention to treatment, by forestalling the neuroendocrine, immunologic or cell cycle-related recurrent susceptibility peaks from getting aligned, favoring cancerous growth. Pituitary/hypothalamic isografts in the virus-free Bagg albino mouse and designs described as heterophasic allow the systematic investigation of the effect of internal shifts among neuroendocrines. Rhythm manipulation by CBRMs can then aim at lowering (breast or prostate) cancer risk by reproducing identified favorable low risk chronome configurations such as a circannual amplitude in blood that is small for TSH and large for prolactin in women and vice versa for men.
Cornélissen
G
G
Chronobiology Laboratories, University of Minnesota, Minneapolis 55455.
Halberg
F
F
D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D008325:Mammary Neoplasms, Experimental / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D008954:Models, Biological; D010507:Periodicity
D007155:Immunologic Factors