Generation of mutant mice lacking surface expression of CD4 or CD8 by gene targeting.
With the use of homologous recombination in embryonic stem cells, two new strains of mice lacking surface CD4 or CD8 expression have been generated. It is hoped that they will be useful mouse strains for the study of autoimmune diseases, tissue transplantation rejections and tumour rejections.
Mak
T W
TW
Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada.
Rahemtulla
A
A
Schilham
M
M
Koh
D R
DR
Fung-Leung
W P
WP
D000818:Animals; D015704:CD4 Antigens; D016827:CD8 Antigens; D005818:Genetic Engineering; D051379:Mice; D008817:Mice, Mutant Strains / Q000276:immunology*; D011995:Recombination, Genetic; D013601:T-Lymphocytes / Q000276:immunology*; D014162:Transfection
D015704:CD4 Antigens; D016827:CD8 Antigens