title: Microgranulomatous aspergillosis after shoveling wood chips: report of a fatal outcome in a patient with chronic granulomatous disease.
abstract: Chronic granulomatous disease is characterized by recurrent infections that result from an inability of phagocytes to kill organisms effectively. We describe a patient with this disease who developed aspergillus pneumonia after shoveling moldy cedar wood chips. Despite aggressive therapy, the patient's condition deteriorated and he died. At autopsy, the lungs revealed diffuse granulomas, all of the same age, with aspergillus organisms confined to the granulomas. We propose the term "microgranulomatous aspergillosis" for this response, which does not conform to the commonly described aspergillus syndromes. We conclude that susceptible immunosuppressed patients should be advised to avoid occupational situations where high spore concentrations are generated.
authors.affiliation: Department of Medicine, University of California, San Francisco 94143.
authors.forename: D J
authors.initials: DJ
authors.lastname: Conrad
authors.forename: M
authors.initials: M
authors.lastname: Warnock
authors.forename: P
authors.initials: P
authors.lastname: Blanc
authors.forename: M
authors.initials: M
authors.lastname: Cowan
authors.forename: J A
authors.initials: JA
authors.lastname: Golden
mesh_terms: D000328:Adult; D001228:Aspergillosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D001344:Autopsy; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D008168:Lung / Q000473:pathology; D008172:Lung Diseases, Fungal / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D008297:Male; D009784:Occupational Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D011859:Radiography; D013997:Time Factors; D014934:Wood