title: Identification of O-methyldopa in the ventricular fluid of patients with Parkinson's disease.
abstract: A newly developed liquid chromatographic system with a multiple electrode detector was used for quantification of neurochemical substances in ventricular fluid of patients with Parkinson's disease. During the analysis, an unknown peak was observed at almost the same high-performance liquid chromatography retention time as 5-hydroxytryptophan. Through the use of ion suppression techniques, voltammographic analysis and fast atom bombardment mass spectrometry, the compound was identified as O-methyldopa, the major metabolite of L-dopa.
authors.affiliation: Department of Neuropsychopharmacology (Tsumura), Gunma University, School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ikarashi
authors.forename: Y
authors.initials: Y
authors.lastname: Maruyama
mesh_terms: D002552:Cerebral Ventricles / Q000737:chemistry / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D002853:Chromatography, Liquid; D004563:Electrochemistry; D006801:Humans; D007202:Indicators and Reagents; D008750:Methyldopa / Q000134:cerebrospinal fluid*; D010300:Parkinson Disease / Q000134:cerebrospinal fluid*; D012701:Serotonin / Q000378:metabolism; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: D007202:Indicators and Reagents; D012701:Serotonin; D008750:Methyldopa