Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein.
Loss-of-function mutations in the yan gene result in the differentiation of supernumerary photoreceptors in the Drosophila eye. The yan gene encodes a protein with an ETS DNA-binding domain that accumulates in the nuclei of undifferentiated cells during the early stages of eye development. Our data suggest that yan functions as a cell-autonomous negative regulator of photoreceptor development; in the presumptive R7 and cone cells, yan appears to act antagonistically to the proneural signal mediated by sevenless and Ras1.
Lai
Z C
ZC
Howard Hughes Medical Institute, University of California, Berkeley 94720.
Rubin
G M
GM
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000302:isolation & purification; D004330:Drosophila / Q000196:embryology / Q000235:genetics*; D029721:Drosophila Proteins; D005136:Eye Proteins / Q000235:genetics* / Q000302:isolation & purification; D005786:Gene Expression Regulation; D008969:Molecular Sequence Data; D009024:Morphogenesis; D009154:Mutation; D010786:Photoreceptor Cells / Q000196:embryology*; D012097:Repressor Proteins; D016415:Sequence Alignment; D014157:Transcription Factors / Q000235:genetics*
C076188:AOP protein, Drosophila; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D005136:Eye Proteins; D012097:Repressor Proteins; D014157:Transcription Factors