title: Bioavailability of ivermectin administered orally to dogs.
abstract: The bioavailability of three formulations of ivermectin was determined following oral administration to dogs. The average peak plasma level (Cmax) of ivermectin administered in the standard tablet formulation at 6 and 100 micrograms/kg of body weight was 2.97 and 44.31 ng/g, respectively. This suggest dose-dependent pharmacokinetics. Cmax and total ivermectin bioavailability, as assessed from the area under the plasma curve (AUC), were similar between two tablet formulations of ivermectin administered at 100 micrograms/kg. Furthermore, Cmax was similar following administration of radiolabelled ivermectin at 6 micrograms/kg in either a beef-based chewable formulation or in the standard tablet formulation.
authors.affiliation: Merck Sharp and Dohme Research Laboratories, Rahway, NJ 07065.
authors.forename: C P
authors.initials: CP
authors.lastname: Daurio
authors.forename: E N
authors.initials: EN
authors.lastname: Cheung
authors.forename: A R
authors.initials: AR
authors.lastname: Jeffcoat
authors.forename: B J
authors.initials: BJ
authors.lastname: Skelly
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D004285:Dogs / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007559:Ivermectin / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D007559:Ivermectin