Comparative study of the biodisposition of benzanthrone in different rodent species.
The bio-elimination and organ retention of [14C]benzanthrone, an anthraquinone dye intermediate, were determined in rats, mice and guinea pigs. Urinary excretion of benzanthrone during 96 hr was higher in guinea pigs (28%) compared with rats and mice (19%). However, faecal elimination during 96 hr was higher in rats (39%) and mice (42%) than in guinea pigs (25%). Urinary elimination of benzanthrone in rats and mice was highest between 12 and 24 hr, while guinea pigs showed a peak value between 24 and 48 hr. The maximum amount of radiolabelled benzanthrone was eliminated through faeces at 24-48 hr in all the three animal species. The retention of [14C]benzanthrone in the liver was comparable in rats (11.2%) and mice (11.9%), while in guinea pigs it was substantially higher (21.9%). The testes of rats and mice were devoid of radioactivity, whereas those of guinea pigs showed a marginal retention (1.25%) of 14C. The present study suggests that guinea pigs are more prone to benzanthrone toxicity than are rats and mice since the bio-elimination of this compound is slower and its organ retention is higher in this species.
Garg
K
K
Dyes and Food Adulterant Toxicology Laboratory, Industrial Toxicology Research Centre, Lucknow, India.
Khanna
S K
SK
Das
M
M
Singh
G B
GB
D000818:Animals; D001551:Benz(a)Anthracenes / Q000493:pharmacokinetics*; D004064:Digestive System / Q000378:metabolism; D005243:Feces / Q000737:chemistry; D006168:Guinea Pigs / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice / Q000378:metabolism*; D051381:Rats / Q000378:metabolism*; D013737:Testis / Q000378:metabolism; D014018:Tissue Distribution
D001551:Benz(a)Anthracenes; C012768:benzanthrone