[Platelets and migraine].
Platelet function studies in migraine patients have evidenced a number of anomalies (hyperreactivity and serotonin metabolism disorders) that have been suggested as causative factors in migraine attacks. However, a review of the literature shows that these disorders are inconsistent and are probably consequences rather than causes of the headache, although they may contribute to the pathophysiology of the attack. From a broader perspective, the demonstration of platelet dysfunction in migraine raises questions as to the source of these disorders (secondary to plasma factors or due to platelet anomalies) and their significance (do they have any link with transient ischemic attacks or central serotonin neurotransmission dysfunction?).
Ollat
H
H
Association pour la Neuro-Psycho-Pharmacologie, Paris, France.
Gurruchaga
J M
JM
D001008:Anxiety Disorders / Q000517:prevention & control; D015239:Arylsulfotransferase / Q000097:blood; D001791:Blood Platelet Disorders / Q000097:blood*; D003937:Diagnosis, Differential; D006801:Humans; D002546:Ischemic Attack, Transient / Q000097:blood / Q000175:diagnosis; D008881:Migraine Disorders / Q000097:blood* / Q000175:diagnosis / Q000517:prevention & control; D008995:Monoamine Oxidase / Q000097:blood; D019964:Mood Disorders / Q000517:prevention & control; D010974:Platelet Aggregation / Q000502:physiology; D012701:Serotonin / Q000097:blood; D012702:Serotonin Antagonists / Q000627:therapeutic use
D012702:Serotonin Antagonists; D012701:Serotonin; D008995:Monoamine Oxidase; D015239:Arylsulfotransferase
Plaquettes et migraine.