Nucleotide sequence of a fragment of the rat tryptophan oxygenase gene showing high affinity to glucocorticoid receptor in vitro.
A nucleotide sequence (3.2 kb) of a DNA region located approximately between introns 4 and 7 of the rat tryptophan oxygenase gene was determined. Using filter binding studies and monoclonal antibodies against the glucocorticoid receptor a high affinity binding of this region to the glucocorticoid receptor was demonstrated.
Merkulov
V M
VM
Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk.
Merkulova
T I
TI
D000818:Animals; D000911:Antibodies, Monoclonal; D001483:Base Sequence; D001665:Binding Sites; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D007438:Introns; D008969:Molecular Sequence Data; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D015183:Restriction Mapping; D014366:Tryptophan Oxygenase / Q000235:genetics*
D000911:Antibodies, Monoclonal; D004268:DNA-Binding Proteins; D011965:Receptors, Glucocorticoid; D004247:DNA; D014366:Tryptophan Oxygenase