title: Carboplatin (CBDCA), 5-fluorouracil (5-FU) and mitoxantrone (DHAD): an effective and well tolerated regimen for metastatic breast cancer.
abstract: Fifty-five women with metastatic breast cancer were treated with carboplatin (CBDCA), 55 mg/m2 i.v. bolus, daily for 3 days, 5-fluorouracil (5-FU) 900 mg/m2, (max. dose 1,500 mg/day in 24-h infusion (Travenol system) daily for 3 days, and mitoxantrone (DHAD) 8 mg/m2, i.v. bolus on day 1. Cycles were administered every 5 weeks. Objective responses were observed in 25 (44%) patients (95% confidence interval: 28%-60%) with a median duration of remission of 11.5+ months (range 6.5(+)-31+). Toxicity was mild. These results reflect the fact that combination of CBDCA, 5-FU and DHAD is effective and very well tolerated as an outpatient regimen.
authors.affiliation: Department of Oncology, Clínica Universitaria de Navarra, Pamplona, Spain.
authors.forename: O F
authors.initials: OF
authors.lastname: Hidalgo
authors.forename: F G
authors.initials: FG
authors.lastname: Gonzalez
authors.forename: J M
authors.initials: JM
authors.lastname: Vieitez
authors.forename: J
authors.initials: J
authors.lastname: Rebollo
authors.forename: E
authors.initials: E
authors.lastname: Tangco
authors.forename: P
authors.initials: P
authors.lastname: Herranz
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D016190:Carboplatin / Q000008:administration & dosage; D004341:Drug Evaluation; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008875:Middle Aged; D008942:Mitoxantrone / Q000008:administration & dosage; D009362:Neoplasm Metastasis
chemical_list: D016190:Carboplatin; D008942:Mitoxantrone; D005472:Fluorouracil