Defect of the potassium transport process in the kidney of spontaneously hypertensive rats.
We investigated the natriuretic and kaliuretic effect of distal tubular diuretics in saline-loaded spontaneously hypertensive Wistar rats (SHR) from three different sources and normotensive Wistar rats (NWR). Orally administered early distal tubular diuretics (hydrochlorothiazide, chlorthalidone, metolazone, indapamide and cicletanine) caused much less potassium excretion in SHR than in NWR, whereas the magnitude of concurrent natriuresis was similar in both NWR and SHR. The intriguing renal handling of potassium excretion was exemplified by hydrochlorothiazide, for which enhanced kaliuresis was dose dependent in NWR but not in SHR. The doses tested ranged from 1 to 100 mg/kg, p.o. Amiloride, a late distal tubular diuretic, was also evaluated for its effect on sodium and potassium excretion in NWR and SHR. Amiloride produced potassium retention more effectively in NWR than in SHR, although the magnitude of natriuresis was similar. The difference between SHR and NWR with regard to potassium-retaining activity of amiloride was consistent at all doses tested (1-30 mg/kg, p.o.). In conclusion, it was suggested that SHR appear to have a genetic defect in potassium transport in the distal nephron.
Kau
S T
ST
Department of Pharmacology, ICI Americas Inc., Wilmington, Del. 19897.
Pritchard
W J
WJ
Leszczynska
K
K
D000284:Administration, Oral; D000818:Animals; D004232:Diuretics / Q000008:administration & dosage; D006973:Hypertension / Q000235:genetics / Q000378:metabolism*; D007686:Kidney Tubules, Distal / Q000187:drug effects / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism* / Q000652:urine; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D015499:Renal Tubular Transport, Inborn Errors / Q000235:genetics / Q000378:metabolism; D012964:Sodium / Q000652:urine
D004232:Diuretics; D012964:Sodium; D011188:Potassium