title: Periventricular plaques in multiple sclerosis: irreversible? An MRI follow-up study.
abstract: Follow-up MRIs over a period of 2-3 years in 50 patients with multiple sclerosis demonstrate that, in contrast to the circumscribed nonperiventricular lesions of the cerebral white matter, the periventricular plaques only show a remission in exceptional cases as ovoid lesions adjacent to the pars centralis of the lateral ventricles. 90% of the patients exhibited at least one new or enlarged nonperiventricular lesion. 72% had more pronounced periventricular lesions in the second scan. With the help of serial MRIs, inferences can be drawn about the histopathological stage of individual demyelination plaques.
authors.affiliation: Department of Neurology, Rudolf Virchow University Clinic, Free University of Berlin, FRG.
authors.forename: K
authors.initials: K
authors.lastname: Baum
authors.forename: C
authors.initials: C
authors.lastname: Nehrig
authors.forename: W
authors.initials: W
authors.lastname: Schörner
authors.forename: W
authors.initials: W
authors.lastname: Girke
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002552:Cerebral Ventricles / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000473:pathology*; D009186:Myelin Sheath / Q000473:pathology; D009460:Neurologic Examination; D011446:Prospective Studies