title: [Aluminum poisoning caused by the phosphate binder in a non-dialysed child with chronic renal insufficiency].
abstract: In patients with chronic renal failure, aluminium, which is included in the dialysate or released from phosphate binders, cannot be eliminated adequately. It forms a deposit in the tissues and leads to intoxication. After a 6-month therapy with aluminium-containing phosphate binders in a non-dialysed baby with chronic renal insufficiency, an osteomalacia arose with distinct subepiphyseal and metaphyseal changes attributable to disorders of mineralization. The consequence of this was a "bone-within-bone" appearance and pathological fractures. After a change of therapy, the bone alterations receded within a few months. Simultaneously, the distinctly elevated serum level of aluminium fell. Therefore, aluminium should be avoided in non-dialysed children with chronic renal insufficiency.
authors.affiliation: Kinderklinik der Technischen Universität München.
authors.forename: B
authors.initials: B
authors.lastname: Feldmann
authors.forename: D
authors.initials: D
authors.lastname: Färber
authors.forename: B F
authors.initials: BF
authors.lastname: Pontz
mesh_terms: D000535:Aluminum / Q000097:blood / Q000506:poisoning*; D006801:Humans; D007231:Infant, Newborn; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy*; D008297:Male; D010018:Osteomalacia / Q000139:chemically induced*; D010710:Phosphates / Q000097:blood*
chemical_list: D010710:Phosphates; D000535:Aluminum
vernacular_title: Aluminiumintoxikation durch Phosphatbinder bei einem nicht dialysierten Kind mit chronischer Niereninsuffizienz.