title: Intra-tympanic injections in the treatment of tinnitus.
abstract: Prolonged reduction or abolition of tinnitus has been reported in about two-thirds of patients treated with a single or weekly-repeated injection through the tympanic membrane of either dexamethasone or lignocaine. In a small-scale trial of these treatments, dexamethasone gave 6 patients little benefit but few side-effects. Lignocaine gave 5 patients no lasting benefit but violent vertigo for several hours. A. Axelsson (personal communication) had similar experience with 6 patients treated with intra-tympanic lignocaine. It is concluded that this form of treatment does not seem sufficiently effective to offset its low acceptability.
authors.affiliation: MRC Institute of Hearing Research, University Park, Nottingham, UK.
authors.forename: R R
authors.initials: RR
authors.lastname: Coles
authors.forename: A C
authors.initials: AC
authors.lastname: Thompson
authors.forename: G M
authors.initials: GM
authors.lastname: O'Donoghue
mesh_terms: D000328:Adult; D000368:Aged; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015552:Injections, Intralesional; D008012:Lidocaine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D014012:Tinnitus / Q000188:drug therapy*; D014432:Tympanic Membrane
chemical_list: D003907:Dexamethasone; D008012:Lidocaine