title: Gut mucosal lymphocyte subpopulations in the host-defence of Shigella infected guinea-pigs.
abstract: Lymphocyte subpopulations from the gut mucosa were studied in Shigella-susceptible guinea-pigs to evaluate their role in mucosal immune responses to such organisms. Four weeks after infection, isolated lymphocytes were characterised by an immunofluorescent technique. The increase in the T cell intra-epithelial population was less (48%) in comparison to that in normal uninfected animals (74%). On the other hand, Ig bearing B cells in the lamina propria showed an increased incidence and more than 15% of the total mucosal lymphocytes lacked any surface marker, which indicated that they were non-T and non-B cells. A significant rise in the intraepithelial T cell population (P less than 0.01) was observed 6 weeks after infection in comparison to that observed after 4 weeks.
authors.affiliation: National Institute of Cholera and Enteric Diseases, Beliaghata, Calcutta, India.
authors.forename: A K
authors.initials: AK
authors.lastname: Sinha
authors.forename: M K
authors.initials: MK
authors.lastname: Chakraborti
authors.forename: S
authors.initials: S
authors.lastname: Chakraborti
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D000954:Antigens, Surface / Q000032:analysis; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology; D004198:Disease Susceptibility / Q000276:immunology; D004405:Dysentery, Bacillary / Q000276:immunology*; D004848:Epithelium / Q000276:immunology; D006168:Guinea Pigs; D007413:Intestinal Mucosa / Q000276:immunology* / Q000648:ultrastructure; D007958:Leukocyte Count; D016131:Lymphocyte Subsets / Q000276:immunology*; D012762:Shigella dysenteriae / Q000276:immunology*
chemical_list: D000942:Antigens, Bacterial; D000954:Antigens, Surface; D001425:Bacterial Outer Membrane Proteins