[The effect of carbohydrate metabolic changes during pregnancy on the capacity of liver mitochondria in rat progeny to oxidize the lipid intermediate].
Respiration rate, respiration control and ADP of liver mitochondria were studies in one-, ten-, and twenty-day-old rats born of females who had received subcutaneous insulin injections (0.25 U/100 g body weight) on days 5-7, 11-13 and 19-21 of pregnancy or glucose (1 g/100 g body weight, in the morning before feeding). Caprylate, an intermediate of the lipid metabolism, was used as the substrate for oxidation. In the control, caprylate oxidation in one-day old rats occurred at a low rate without providing for synthesis of ATP from ADP and phosphate. Insulin administration and alimentary hyperglycemia in females on days 5-7 of pregnancy had no significant effect on respiration rate of liver mitochondria in progeny of all ages tested. Administration of the above preparations on days 11-13 and 19-21 of pregnancy improved caprylate oxidation in mitochondria of the newborn rats. In other series the difference between experiments and the control was insignificant. Metabolic changes in the newborns are shown to be related to hyperinsulinemia in pregnant females.
Makhmudov
E S
ES
Akhmerov
R N
RN
Babaeva
R N
RN
Baratova
G Kh
GKh
D000818:Animals; D000831:Animals, Newborn; D002210:Caprylates / Q000378:metabolism; D050260:Carbohydrate Metabolism; D005260:Female; D007328:Insulin / Q000008:administration & dosage; D015227:Lipid Peroxidation / Q000187:drug effects*; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D010085:Oxidative Phosphorylation / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains
D002210:Caprylates; D007328:Insulin
Vliianie izmeneniĭ uglevodnogo obmena vo vremia beremennosti na sposobnost' mitokhondriĭ pecheni potomstva krys okisliat' lipidnyĭ intermediat.