title: The hydrodynamic function and leaflet dynamics of aortic and pulmonary roots and valves: an in vitro study.
abstract: Fresh homograft aortic and pulmonary roots were tested in a pulsatile flow simulator to assess their hydrodynamic function and leaflet opening characteristics. Simultaneous flow and pressure measurements were obtained for a range of cardiac outputs. The effective orifice area and regurgitant volumes were calculated. The mean pressure difference across the pulmonary roots was obtained under both left and right side pressures. A video recording of valve leaflet function was also obtained for each valve. A comparison was made with four porcine bioprosthetic heart valves (21 and 23 mm). The mean pressure difference with respect to flow for the 21 mm Hancock II and Intact porcine bioprostheses was significantly higher than that for all aortic roots tested. The 24 mm aortic root showed significantly lower pressure drop compared to all porcine valves tested. The mean pressure difference across each pulmonary root at pulmonary pressures was significantly greater than at systemic pressures. At systemic pressures the fully open leaflets had a triangular orifice with low leaflet open bending strains at the commissures. At the lower internal pressures, with reduced dilation of the root, higher bending strains were noted. These were not as severe as seen in porcine valves.
authors.affiliation: Cardiac Research Unit, Killingbeck Hospital, Leeds, UK.
authors.forename: N
authors.initials: N
authors.lastname: Weerasena
authors.forename: K J
authors.initials: KJ
authors.lastname: Lockie
authors.forename: M
authors.initials: M
authors.lastname: Butterfield
authors.forename: J
authors.initials: J
authors.lastname: Fisher
authors.forename: J N
authors.initials: JN
authors.lastname: Kearney
authors.forename: G A
authors.initials: GA
authors.lastname: Davies
mesh_terms: D000328:Adult; D001021:Aortic Valve / Q000502:physiology*; D001696:Biomechanical Phenomena; D001705:Bioprosthesis; D001794:Blood Pressure / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006350:Heart Valve Prosthesis; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D011474:Prosthesis Design; D011475:Prosthesis Failure; D011664:Pulmonary Valve / Q000502:physiology*