title: Age-dependent alterations of synaptic performance and plasticity in crustacean motor systems.
abstract: Age-related changes in synaptic performance and plasticity are surveyed in crustacean neuromuscular systems. These systems are functionally differentiated into phasic and tonic types, with different attributes of synaptic function and plasticity. Conversion of phasic neuromuscular junctions to a more phasic phenotype can be brought about by altering the activity of selected neurons. This type of plasticity disappears in older animals in some motor neurons, but is retained in others. Developmental programs set constraints on the age-dependent modifications of plasticity. Crustacean motor neurons are often characterized by great longevity, with progressive addition of new branches and synapses to keep up with growth of innervated muscle cells. Certain age-related compensatory mechanisms found in neuromuscular junctions of other species may not be required in crustaceans.
authors.affiliation: Department of Physiology, University of Toronto, Ontario, Canada.
authors.forename: H L
authors.initials: HL
authors.lastname: Atwood
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D003445:Crustacea / Q000502:physiology*; D009046:Motor Neurons / Q000502:physiology; D009469:Neuromuscular Junction / Q000254:growth & development / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D013569:Synapses / Q000502:physiology*