Influence of area of application of allergen on sensitization in contact dermatitis.
There are at least 2 quantitative variables when applying allergens to obtain sensitization: the absolute amount of allergen and the surface concentration. This review analyzes the limited studies on surface concentration and determines surface area threshold levels for the allergens documented in the literature.
Upadhye
M R
MR
Department of Dermatology, University of California, San Francisco 94143.
Maibach
H I
HI
D000485:Allergens / Q000008:administration & dosage*; D000818:Animals; D001830:Body Surface Area; D017449:Dermatitis, Allergic Contact / Q000276:immunology*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006801:Humans
D000485:Allergens