What differentiates antiestrogen-liganded vs estradiol-liganded estrogen receptor action?
This paper provides an annotated summary of the current literature detailing what is known about the interaction of antiestrogen-liganded estrogen receptor (ER) vs estradiol-liganded ER with DNA in vitro and in vivo. It describes the current models of the mechanism by which antiestrogen-liganded ER blocks transcription of certain estrogen-regulated genes.
Klinge
C M
CM
Department of Biochemistry, University of Rochester Medical Center, New York 14642.
Bambara
R A
RA
Hilf
R
R
D001943:Breast Neoplasms / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004958:Estradiol / Q000378:metabolism*; D004965:Estrogen Antagonists / Q000378:metabolism*; D005260:Female; D005809:Genes, Regulator; D006801:Humans; D008024:Ligands; D008954:Models, Biological; D011960:Receptors, Estrogen / Q000378:metabolism*; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D004965:Estrogen Antagonists; D008024:Ligands; D011960:Receptors, Estrogen; D004958:Estradiol