title: A study of tobacco carcinogenesis. XLVII. Bioassays of vinylpyridines for genotoxicity and for tumorigenicity in A/J mice.
abstract: 3-Vinylpyridine is formed from nicotine during the smoking of tobacco products. Consequently it is found in mainstream and side-stream smoke of cigarettes and cigars and in environmental tobacco smoke. In this study, 3-vinylpyridine and its isomers 2- and 4-vinylpyridine as well as styrene (vinylbenzene) were bioassayed for mutagenicity in Salmonella typhimurium strains TA 1535, TA 1538, TA 98 and TA 100 and for their genotoxicity in the rat hepatocyte DNA-repair test. In both in vitro assays-all three vinylpyridines and styrene were inactive. In a test for tumorigenicity in which the test compounds were injected intraperitoneally into A/J mice (total dose 200 mumol/animal) there was no significant incidence of lung adenoma nor of any other type of tumors.
authors.affiliation: American Health Foundation, Valhalla, New York 10595.
authors.forename: K D
authors.initials: KD
authors.lastname: Brunnemann
authors.forename: A
authors.initials: A
authors.lastname: Rivenson
authors.forename: S C
authors.initials: SC
authors.lastname: Cheng
authors.forename: V
authors.initials: V
authors.lastname: Saa
authors.forename: D
authors.initials: D
authors.lastname: Hoffmann
mesh_terms: D000818:Animals; D001711:Biotransformation; D002273:Carcinogens / Q000494:pharmacology / Q000633:toxicity*; D004260:DNA Repair; D005260:Female; D008099:Liver / Q000187:drug effects; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000473:pathology; D051379:Mice; D008805:Mice, Inbred A; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology / Q000633:toxicity*; D009297:Nasal Mucosa / Q000187:drug effects / Q000473:pathology*; D009602:Nitrosamines / Q000494:pharmacology / Q000633:toxicity; D011725:Pyridines / Q000494:pharmacology / Q000633:toxicity*; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects; D012907:Smoking / Q000009:adverse effects*; D020058:Styrene; D013343:Styrenes / Q000494:pharmacology / Q000633:toxicity*; D014028:Tobacco Smoke Pollution / Q000009:adverse effects; D014753:Vinyl Compounds / Q000494:pharmacology / Q000633:toxicity*
chemical_list: D002273:Carcinogens; D009153:Mutagens; D009602:Nitrosamines; D011725:Pyridines; D013343:Styrenes; D014028:Tobacco Smoke Pollution; D014753:Vinyl Compounds; D020058:Styrene; C016583:4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; C030953:2-vinylpyridine; C029351:4-vinylpyridine; C076387:3-vinylpyridine