[Effect of prostaglandin E2 on ion regulating and acid excretory function of the kidneys].
Prostaglandin E2 action on ion regulating and acid excretory function of the kidneys was investigated in acute experiments on intact male rats whose angiotensin-converting enzyme (ACE) had been blocked by enalapril. It was shown that i.p. two-fold PGE2 injection (0.5 mg/kg) during water load decreased diuresis, glomerular filtration, excretion of potassium, titration acids, ammonium, and increased urine pH. Sodium excretion was detected only if ACE had been blocked. In both series of experiments, an increase in chloride excretion was found to be statistically significant. A conclusion has been made that PGE2 influences directly the inhibition of acid excretory function of the kidneys.
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D000143:Acids / Q000378:metabolism*; D000818:Animals; D002712:Chlorides / Q000652:urine; D015232:Dinoprostone / Q000502:physiology*; D004231:Diuresis / Q000502:physiology; D004656:Enalapril / Q000494:pharmacology; D005919:Glomerular Filtration Rate / Q000502:physiology; D006863:Hydrogen-Ion Concentration; D007477:Ions; D007668:Kidney / Q000378:metabolism / Q000502:physiology*; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D011188:Potassium / Q000652:urine; D051381:Rats; D012084:Renin-Angiotensin System / Q000187:drug effects
D000143:Acids; D002712:Chlorides; D007477:Ions; D004656:Enalapril; D015232:Dinoprostone; D011188:Potassium
Vliianie prostaglandina E2 na ionoreguliruiushchuiu i kislotovydelitel'nuiu funktsii pochek.