Serum IgG antibody to ganglioside GQ1b is a possible marker of Miller Fisher syndrome.
We studied serum anti-glycolipid antibodies by enzyme-linked immunosorbent assay and thin-layer chromatography-enzyme immunoassay in six consecutive patients with typical Miller Fisher syndrome. In all six, increased activity of IgG antibody against ganglioside GQ1b was present in the early phase and reduced with time, whereas such activity was not detected in normal control subjects and disease control subjects including those with Guillain-Barré syndrome. Anti-GQ1b IgG antibody is a new possible diagnostic marker of Miller Fisher syndrome and could well be related to the disease process itself.
Chiba
A
A
Department of Neurology, School of Medicine, University of Tokyo, Japan.
Kusunoki
S
S
Shimizu
T
T
Kanazawa
I
I
D000328:Adult; D000368:Aged; D000918:Antibody Specificity; D001259:Ataxia / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology; D015415:Biomarkers; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D006017:Glycolipids / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology; D009886:Ophthalmoplegia / Q000276:immunology*; D011129:Polyradiculoneuropathy / Q000276:immunology; D012021:Reflex, Abnormal; D013577:Syndrome
D001323:Autoantibodies; D015415:Biomarkers; D005732:Gangliosides; D006017:Glycolipids; D007074:Immunoglobulin G; C039129:GQ1b ganglioside