Muscle blood flow in diabetes mellitus. Evidence of abnormality after exercise.
OBJECTIVE
To determine whether muscle blood flow before and after exercise is abnormal in patients with diabetes mellitus.


METHODS
Muscle blood flow (MBF) was measured with the 133Xe clearance technique in 15 nondiabetic subjects, 10 patients with insulin-dependent diabetes mellitus (IDDM), and 11 patients with non-insulin-dependent diabetes (NIDDM) at rest and after exercise. None of the patients had neuropathy.


RESULTS
The median resting MBF was similar in all three groups. The median postexercise MBF was significantly greater in nondiabetic subjects (40.1 ml.min-1.100 g-1 of tissue) than in patients with IDDM (25.7 ml.min-1.100 g-1 of tissue; P less than 0.01) or NIDDM (14 ml.min-1.100 g-1 of tissue; P less than 0.01). The difference between IDDM and NIDDM was not significant.


CONCLUSIONS
Diabetic patients have abnormalities of MBF in response to exercise. This abnormality occurs in the absence of clinical diabetic neuropathy.
Menon
R K
RK
Department of Chemical Pathology and Human Metabolism, Royal Free Hospital and School of Medicine, London, United Kingdom.
Grace
A A
AA
Burgoyne
W
W
Fonseca
V A
VA
James
I M
IM
Dandona
P
P
D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009132:Muscles / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000503:physiopathology; D005082:Physical Exertion; D011877:Radionuclide Imaging; D012016:Reference Values; D012039:Regional Blood Flow; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes