title: [Migraine and non-steroidal anti-inflammatory agents].
abstract: Controlled studies of nonsteroidal antiinflammatory drugs (NSAIDs) for the management of migraine attacks or for the prophylactic long-term treatment of migraine are reviewed herein. A large number of NSAIDs have been tested against a placebo or reference drug, including aspirin, indomethacin, mefenamic acid, tolfenamic acid, flufenamic acid, ibuprofen, flurbiprofen, fenoprofen, naproxen and sodium naproxen, diclofenac and lornoxicam. For the treatment of acute attacks, published studies found that the NSAIDs were significantly more effective than the placebo and at least as effective as the reference drugs. Adverse effects were absent or mild in this indication. Studies of NSAIDs as prophylactic treatment of migraine attacks are less numerous but also point to the value of this approach. However, long-term use of NSAIDs is associated with side-effects, mainly involving the gastrointestinal tract.
authors.affiliation: Service de Médecine Interne, Hôpital Rothschild, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Pradalier
authors.forename: D
authors.initials: D
authors.lastname: Vincent
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use; D004008:Diclofenac / Q000627:therapeutic use*; D004878:Ergotamine / Q000627:therapeutic use; D005439:Flufenamic Acid / Q000627:therapeutic use*; D005480:Flurbiprofen / Q000627:therapeutic use*; D006801:Humans; D008787:Metoclopramide / Q000627:therapeutic use; D008881:Migraine Disorders / Q000188:drug therapy* / Q000517:prevention & control; D009288:Naproxen / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D062367:ortho-Aminobenzoates / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D062367:ortho-Aminobenzoates; D004008:Diclofenac; D000082:Acetaminophen; C009500:tolfenamic acid; D009288:Naproxen; D005480:Flurbiprofen; D005439:Flufenamic Acid; D008787:Metoclopramide; D004878:Ergotamine; D001241:Aspirin
vernacular_title: Migraine et anti-inflammatoires non-stéroïdiens.