title: Anti-toxoplasma serotitres in uveitis and ocular toxoplasmosis.
abstract: This study was based on anti-toxoplasma serotitres obtained from 80 normal healthy adults and 103 consecutive patients with anterior, posterior and panuveitis over a 42 month period. Twelve out of 80 (15%) normal healthy sera were found to have low titres (1:64 to 1:256), while 3 (3.8%) had high titres (1:1024 or higher). The distribution of serotitres in patients with clinical toxoplasmosis was significantly different from the population sample (p less than 0.001, chi-squared test). Similarly, the distribution of serotitres in patients with posterior uveitis (of which 28 out of 54 were clinically ocular toxoplasmosis) having serotitres of 1:1024 or greater, was found to be significantly different from the normal population (p less than 0.001, Chi-squared test), but not statistically different from those with clinical ocular toxoplasmosis. Hence, anti-toxoplasma serotitre is useful as a diagnostic screening tool only in patients with posterior uveitis. It is also useful in confirming cases of suspected clinically positive ocular toxoplasmosis in our local population.
authors.affiliation: Singapore National Eye Centre.
authors.forename: S P
authors.initials: SP
authors.lastname: Chee
authors.forename: S
authors.initials: S
authors.lastname: Seah
authors.forename: S G
authors.initials: SG
authors.lastname: Ong
authors.forename: T C
authors.initials: TC
authors.lastname: Mohan
authors.forename: E H
authors.initials: EH
authors.lastname: Sng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood*; D005260:Female; D005455:Fluorescent Antibody Technique / Q000592:standards; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods / Q000592:standards; D008875:Middle Aged; D015864:Panuveitis / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D015995:Prevalence; D016036:Seroepidemiologic Studies; D012846:Singapore / Q000453:epidemiology; D014122:Toxoplasma / Q000276:immunology*; D014126:Toxoplasmosis, Ocular / Q000150:complications* / Q000453:epidemiology; D014606:Uveitis, Anterior / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D015866:Uveitis, Posterior / Q000097:blood* / Q000453:epidemiology / Q000209:etiology
chemical_list: D000913:Antibodies, Protozoan