title: Seminal vesicle amyloid: the first example of exocrine cell origin of an amyloid fibril precursor.
abstract: Amyloid fibrils have been extracted from seminal vesicles, and a dominant 14 kD amyloid fibril protein has been identified. An antiserum to this protein reacted both with amyloid and with epithelial cells in some normal seminal vesicles. These reactions were blocked with seminal vesicle secretion and seminal vesicle amyloid fibril protein, but not by degraded amyloid fibrils or fibril protein from other types of amyloid. It is concluded that seminal vesicle amyloid is derived from secretory proteins of the seminal vesicles. As such, it is the first amyloid described which appears to be the product of an exocrine secretory cell.
authors.affiliation: Department of Medicine, Dartmouth Medical School, Lebanon, NH.
authors.forename: G G
authors.initials: GG
authors.lastname: Cornwell
authors.forename: G T
authors.initials: GT
authors.lastname: Westermark
authors.forename: P
authors.initials: P
authors.lastname: Pitkanen
authors.forename: P
authors.initials: P
authors.lastname: Westermark
mesh_terms: D000368:Aged; D000682:Amyloid / Q000737:chemistry / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D005591:Chemical Fractionation; D004847:Epithelial Cells; D004848:Epithelium / Q000378:metabolism / Q000648:ultrastructure; D005088:Exocrine Glands / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D015151:Immunoblotting; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D012669:Seminal Vesicles / Q000166:cytology / Q000378:metabolism* / Q000648:ultrastructure
chemical_list: D000682:Amyloid; D016564:Amyloid beta-Protein Precursor