title: Cytotoxic quassinoids from Cedronia granatensis.
abstract: The NCI in vitro primary disease-oriented antitumor screen has been used to select and guide the fractionation of the organic and aqueous extracts of Cedronia granatensis. Two quassinoids, sergiolide [1] and isobrucein B [2], to which the screening panel cell lines exhibited up to a 1000-fold range of differential sensitivity, were isolated. At concentrations of 10(-5)-10(-8) M, the compounds typically produced LC50-level responses against a majority of the melanoma lines and several of the colon, lung, and other solid tumor lines. These and related quassinoids may, therefore, be of interest for in vivo evaluation in appropriate xenograft tumor models.
authors.affiliation: Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland 21702-1201.
authors.forename: M
authors.initials: M
authors.lastname: Tischler
authors.forename: J H
authors.initials: JH
authors.lastname: Cardellina
authors.forename: M R
authors.initials: MR
authors.lastname: Boyd
authors.forename: G M
authors.initials: GM
authors.lastname: Cragg
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005900:Glaucarubin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D036702:Quassins; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D036702:Quassins; C076339:isobrucein B; C045844:sergeolide; D005900:Glaucarubin