Efficacy of gadoteridol for magnetic resonance imaging of extracranial head and neck pathology.
OBJECTIVE
This study evaluated the efficacy of gadoteridol in patients with extracranial head and neck pathology.


METHODS
One hundred twenty-two magnetic resonance imaging (MRI) cases from a multicenter safety and efficacy trial of gadoteridol in patients with suspected head and neck pathology were randomly assigned for evaluation to one of two blinded neuroradiologists.


RESULTS
Enhancement of pathology after gadoteridol injection was noted in 96 cases (78.7%) and provided additional diagnostic information in 57 cases (46.7%). Improved lesion visualization was noted in 37 (64.9%) of these 57 cases; an increase in the number of lesions seen was noted in 4 (7.0%) of 57 cases. Blinded readers determined that additional diagnostic information provided by gadoteridol would have resulted in a change in diagnosis in 20 (35.1%, or 16.4% of total population) of 57 patients.


CONCLUSIONS
These results demonstrate that gadoteridol is an efficacious agent for enhanced MRI of head and neck pathology.
Zoarski
G H
GH
Department of Radiological Sciences, University of California Center for the Health Sciences, Los Angeles 90024-1721.
Parker
J R
JR
Lufkin
R B
RB
Harnsberger
H R
HR
Rhoda
C H
CH
D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003287:Contrast Media; D005260:Female; D005682:Gadolinium; D006258:Head and Neck Neoplasms / Q000175:diagnosis*; D006571:Heterocyclic Compounds; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds
D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C062402:gadoteridol; D005682:Gadolinium