title: Role of contrast agent perfusion and of diffusion in the NMR signal enhancement of liver lesions.
abstract: Both perfusion and diffusion contribute to NMR signal enhancement after intravenous injection of a nonspecific contrast agent. In the present study the roles of perfusion and diffusion in the contrast enhancement of induced liver lesions in the rat and the rabbit were evaluated. This was done by comparing Gd-DOTA absolute enhancement signal-to-noise versus time plots of various lesions with the findings from microangiography and histology. Four types of enhancement could be recognized. Diffusion was the major factor in the delayed enhancement seen in lesions that had large extravascular diffusion space.
authors.affiliation: Department of Radiology, University Hospitals K. U. Leuven, Belgium.
authors.forename: G
authors.initials: G
authors.lastname: Marchal
authors.forename: Y
authors.initials: Y
authors.lastname: Ni
authors.forename: B
authors.initials: B
authors.lastname: Van Damme
authors.forename: P
authors.initials: P
authors.lastname: Van Hecke
authors.forename: J
authors.initials: J
authors.lastname: Michiels
authors.forename: J
authors.initials: J
authors.lastname: Yu
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: A L
authors.initials: AL
authors.lastname: Baert
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000175:diagnosis*; D003287:Contrast Media; D004052:Diethylnitrosamine; D004058:Diffusion; D005682:Gadolinium; D006571:Heterocyclic Compounds; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000150:complications / Q000175:diagnosis*; D008113:Liver Neoplasms / Q000139:chemically induced / Q000150:complications / Q000175:diagnosis*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000150:complications / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009368:Neoplasm Transplantation; D009942:Organometallic Compounds; D010477:Perfusion; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; D004052:Diethylnitrosamine; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate; D005682:Gadolinium