title: [The "sarcoidosis-lymphoma syndrome"--a lymphocyte dysregulation?].
abstract: Sarcoidosis and malignant lymphoma can occur in the same patient; sarcoidosis appears first, the malignant lymphoma follows later. The case histories of three patients illustrate what Brinker first coined as the "sarcoidosis-lymphoma syndrome". In two patients a pulmonary sarcoidosis stage I was diagnosed over 30 years respectively 4 years prior to the histological diagnosis of highly malignant Non-Hodgkin lymphoma. The third patient suffered from generalized sarcoidosis with splenomegaly, , granulomatous hepatitis and interstitial lung disease, in addition to which a lymphoproliferative syndrome was diagnosed. Comparing the pathogenesis of malignant lymphoma and sarcoidosis, parallels such as T-cell dysfunction, which probably facilitates malignant transformation of B-cells, become apparent. In both diseases the transforming gene could be the Ebstein-Barr virus.
authors.affiliation: Departement für Innere Medizin, Universität Zürich.
authors.forename: H S
authors.initials: HS
authors.lastname: Linnenberg
authors.forename: T C
authors.initials: TC
authors.lastname: Medici
authors.forename: K
authors.initials: K
authors.lastname: Rhyner
mesh_terms: D000328:Adult; D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000276:immunology; D005260:Female; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology; D008171:Lung Diseases / Q000175:diagnosis / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D008223:Lymphoma / Q000175:diagnosis / Q000276:immunology*; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000175:diagnosis / Q000276:immunology*; D013577:Syndrome
vernacular_title: Das "Sarkoidose-Lymphom-Syndrome"--Eine Lymphozyten-Fehlregulation?