title: Peripheral ischaemia and gangrene presenting at birth.
abstract: The aetiology of non-iatrogenic causes of peripheral ischaemia and gangrene presenting either at birth or within a few hours of delivery is unknown in the majority of 56 confirmed cases. In this review of 47 cases occurring since 1941 the aetiology was clear in only 6, four due to compression by the encircling umbilical cord. There was no clear association with gestational age, birth weight, maternal age or type of delivery. Seven were infants of poorly controlled diabetic mothers and these may constitute a subgroup due to altered haemostatic mechanisms. Pregnancy hypertension was an association in 7 cases, oligohydramnios in 6. There is only limited support for birth trauma, sepsis, and thrombo-emboli from the ductus arteriosus as causes. There is indirect evidence that thrombo-emboli can migrate from the placental bed to the fetus. In recent years death from this condition has been rare with surgical thrombectomy increasingly successful in late presenting cases. When gangrene is established at birth surgical amputation, autoamputation, or some loss of function is usual. Peripheral ischaemic insults presenting at birth may be part of a wider spectrum of disorders, both prenatal and perinatal, attributable to occlusive vascular disruption.
authors.affiliation: Department of Paediatrics, Nazareth Hospital, Israel.
authors.forename: P D
authors.initials: PD
authors.lastname: Turnpenny
authors.forename: S
authors.initials: S
authors.lastname: Stahl
authors.forename: D
authors.initials: D
authors.lastname: Bowers
authors.forename: P
authors.initials: P
authors.lastname: Bingham
mesh_terms: D005121:Extremities / Q000098:blood supply*; D005734:Gangrene / Q000151:congenital* / Q000209:etiology / Q000628:therapy; D006801:Humans; D007231:Infant, Newborn; D007511:Ischemia / Q000151:congenital* / Q000209:etiology / Q000628:therapy