title: Role of corticosteroids in the management of chronic obstructive lung disease: factors predicting response.
abstract: A double-blind crossover trial of prednisolone was conducted in 70 patients of chronic obstructive lung disease (COLD). Emphysema dominated the clinical picture in 38, rest being chronic bronchitis with varying degrees of air trapping. None of the patients had clinical asthma. All the patients had obtained maximal benefit from an optimal dose of bronchodilators prior to entering the study. Prednisolone in a dose of 0.8 mg/kg was prescribed in a double blind crossover manner with identical appearing placebo tablets. Patients were evaluated on a weekly basis for an objective as well as a subjective response and side effects of therapy. Thirty-four patients demonstrated a statistically significant improvement in pulmonary functions. In 20 others only subjective response was observed. A good objective response was predicted by a pre-study variability in FEV1, disease duration of less than 10 years and a history of smoking less than 50 pack years.
authors.affiliation: Department of Respiratory Medicine, Safdarjang Hospital, New Delhi.
authors.forename: A
authors.initials: A
authors.lastname: Goel
authors.forename: J C
authors.initials: JC
authors.lastname: Suri
authors.forename: K
authors.initials: K
authors.lastname: Aggarwal
mesh_terms: D001991:Bronchitis / Q000188:drug therapy; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000009:adverse effects / Q000627:therapeutic use*; D011656:Pulmonary Emphysema / Q000188:drug therapy; D012129:Respiratory Function Tests; D012907:Smoking; D013997:Time Factors
chemical_list: D011239:Prednisolone