HDL and apolipoprotein A1 (apo A1). Their effects on retardation of lipid deposition in aortic intima.
The aim of this study is to clarify whether apo A1 displays a similar role as that of HDL in preventing the development of experimental atherosclerosis. Results were obtained from 4 groups of experiments. (1) Result from 4 successive experiments of tree shrews indicated that high serum HDL level is the main factor in preventing the development of experimental atherosclerosis; (2) Results from 4 successive experiments in rabbits showed that both HDL and apo A1 were able to decrease the extent of lipid deposition and atheromatous lesion developed in the aortic intima; (3) Apo A1 also inhibited the number of monocytes/macrophages infiltrated in aortic intima at the initial stage of fatty streak formation; (4) Similar as HDL, apo A1 phospholipid liposomes promoted markedly the clearance ability of smooth muscle cells on intracellular cholesterol. Conclusively, apo A1 is effective in preventing the development of experimental atherosclerosis. Further study, however, is required to detect an ideal combination of apo A1 with other component, e.g., phospholipid.
She
M P
MP
Department of Pathology, Chinese Academy of Medical Sciences, Beijing.
Liang
P
P
Huang
Y D
YD
Cai
C B
CB
Ran
B F
BF
Wang
Z L
ZL
Xia
R Y
RY
D000818:Animals; D001011:Aorta / Q000378:metabolism / Q000473:pathology; D016632:Apolipoprotein A-I / Q000032:analysis* / Q000627:therapeutic use; D001161:Arteriosclerosis / Q000517:prevention & control*; D002784:Cholesterol / Q000378:metabolism; D004036:Diet, Atherogenic; D050356:Lipid Metabolism; D008075:Lipoproteins, HDL / Q000097:blood* / Q000627:therapeutic use; D011817:Rabbits; D014418:Tupaiidae
D016632:Apolipoprotein A-I; D008075:Lipoproteins, HDL; D002784:Cholesterol