Increased activity of the GABAergic system in selected brain areas after chronic propranolol treatment in spontaneously hypertensive rats.
The influence of chronically administered propranolol on the functional state of the gamma-aminobutyric acid-ergic (GABAergic) system in spontaneously hypertensive rats was studied and compared with the effect of dihydralazine. GABA content, synthesis and turnover rate in selected brain areas were assessed. Hypotensive activity of propranolol and dihydralazine after injection of GABA antagonist pictrotoxin was examined in acute experiment. Prolonged administration of propranolol increased GABA content, synthesis and turnover rate in the hypothalamus and the pons-medulla. After chronic injections of dihydralazine there was no change in GABA indices. Antihypertensive activity of dihydralazine in picrotoxin-treated animals remained unchanged. On the contrary, picrotoxin suppressed the propranolol-induced decrease in blood pressure. Our results indicate that propranolol increases GABAergic system activity. Therefore, we conclude that down-regulation of the GABAergic system in hypertension may be compensated by the regulatory action of propranolol.
Remiszewska
M
M
Department of Pharmacology, Institute of Drug Research and Control, Warsaw, Poland.
Jastrzebski
Z
Z
Czyzewska-Szafran
H
H
Wutkiewicz
M
M
Czarnecki
A
A
D000625:Aminooxyacetic Acid / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004078:Dihydralazine / Q000494:pharmacology; D008297:Male; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis / Q000378:metabolism*
D000625:Aminooxyacetic Acid; D004078:Dihydralazine; D010852:Picrotoxin; D005680:gamma-Aminobutyric Acid