Conformational sub-states in B-DNA.
Theoretical studies of the sequence-dependent conformation of B-DNA have been carried out using Jumna, a helicoidal co-ordinate minimization algorithm. The results obtained for a series of six oligomers with repetitive sequences show that, with the exception of the homopolymers (dA)n.(dT)n and (dG)n.(dC)n, all sequences can adopt a variety of conformations characterized by considerable changes in helicoidal parameters and also in sugar puckers which adopt C(2')-endo (falling into 2 classes) or, in the case of pyrimidine nucleotides, O(1')-endo forms. These studies lead to an improved understanding of the role of base sequence on DNA conformation and point to a number of interesting correlations between the various structural parameters describing the double helix.
Poncin
M
M
Laboratoire de Biochimie Théorique, Institut de Biologie Physico-Chimique, Paris, France.
Hartmann
B
B
Lavery
R
R
D000465:Algorithms; D001482:Base Composition; D001483:Base Sequence; D002151:Calorimetry; D004247:DNA / Q000737:chemistry*; D003855:Deoxyribose; D015226:Dinucleoside Phosphates / Q000737:chemistry; D006027:Glycosides; D008433:Mathematics; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D011089:Polydeoxyribonucleotides / Q000737:chemistry
D015226:Dinucleoside Phosphates; D006027:Glycosides; D009838:Oligodeoxyribonucleotides; D011089:Polydeoxyribonucleotides; D003855:Deoxyribose; D004247:DNA