Effect of erythromycin on ciliary motility in rabbit airway epithelium in vitro.
The effect of erythromycin on ciliary beat frequency (CBF) of rabbit tracheal epithelium was studied by a microphoto-oscillation technique in vitro. Addition of erythromycin dose-dependently increased CBF, the maximal increase from the baseline value and EC50 being 23.3 +/- 4.5% (P less than 0.001) and 6.8 +/- 0.9 mg/L, respectively. This effect was not influenced by autonomic receptor antagonists, blockers of arachidonic acid metabolism, Ca(2+)-free medium, or inhibition of protein kinase C and protein kinase A activities.
Tamaoki
J
J
First Department of Medicine, Tokyo Women's Medical College, Japan.
Chiyotani
A
A
Sakai
N
N
Takeyama
K
K
Takizawa
T
T
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002923:Cilia / Q000187:drug effects / Q000502:physiology; D004848:Epithelium / Q000187:drug effects; D004917:Erythromycin / Q000494:pharmacology*; D066298:In Vitro Techniques; D007700:Kinetics; D009991:Oscillometry / Q000379:methods; D011817:Rabbits; D014132:Trachea / Q000187:drug effects* / Q000502:physiology
D004917:Erythromycin; D002118:Calcium