[Post-antibiotic effect and clinical significance].
The postantibiotic effect (PAE) is the phenomenon of suppression of bacterial growth after brief antimicrobial exposure to microorganisms. The presence of PAE may be an important consideration in designing antibiotic dosage regimens. Antimicrobials with minimal or lesser PAEs may require serum concentration above MIC or entire dosing interval. Several antimicrobial actions are affected on the PAE phase, eg. "postantibiotic sub-MIC effect". Moreover, the PAE may contribute to the efficacy on host-parasite relationship. This phenomenon is discussed.
Kikuchi
K
K
Department of Medicine, Tokyo Women's Medical College.
Shimizu
K
K
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001424:Bacterial Infections / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D006801:Humans; D051379:Mice
D000900:Anti-Bacterial Agents