Anti-tetanus toxoid antibodies in intravenous gamma globulin: an alternative to tetanus immune globulin.
The levels of anti-tetanus toxoid IgG antibodies were measured in 29 lots of intravenous gamma globulin (IVIG). The antibody levels varied from 4 to 90 IU/mL (geometric mean, 18.6; 90% confidence interval, 9.7-35.7). The variation from manufacturer to manufacturer accounted for most of the observed differences among lots; there was relatively little variability among multiple lots from a single manufacturer. IVIG may be an acceptable alternative to horse or human tetanus immune globulin.
Lee
D C
DC
Eudowood Division of Pediatric Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Lederman
H M
HM
D000907:Antibodies, Bacterial / Q000032:analysis* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology; D016756:Immunoglobulins, Intravenous / Q000276:immunology*; D013745:Tetanus Toxoid / Q000276:immunology*
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous; D013745:Tetanus Toxoid