title: Volatile N-nitrosamines in mainstream cigarette smoke: occurrence and formation.
abstract: Analytical data is presented for the occurrence of the three major volatile N-nitrosamines in cigarette tobacco and mainstream smoke, namely N-nitrosodimethylamine (NDMA),- N-nitrosoethylmethylamine (NEMA) and N-nitrosopyrrolidine (NPYR) as well as for the occurrence of the corresponding precursor amines and non-volatile N-nitrosamino acids in tobacco. Experimental studies using the C20 reference cigarette show that NPYR present in mainstream smoke results from direct transfer of preformed NPYR (ca. 1.5%), decarboxylation of N-nitrosoproline in tobacco (ca. 10%), pyrolytic nitrosation of pyrrolidine in tobacco (ca. 37%) and concerted decarboxylation/nitrosation of proline (ca. 52%) during tobacco pyrolysis.
authors.affiliation: Institut für Toxikologie und Chemotherapie, Deutsches Krebsforschungszentrum, Heidelberg.
authors.forename: A R
authors.initials: AR
authors.lastname: Tricker
authors.forename: R
authors.initials: R
authors.lastname: Preussmann
mesh_terms: D002849:Chromatography, Gas; D006358:Hot Temperature; D008956:Models, Chemical; D009602:Nitrosamines / Q000032:analysis* / Q000737:chemistry / Q000145:classification; D010947:Plants, Toxic; D012906:Smoke / Q000032:analysis*; D014026:Nicotiana / Q000737:chemistry
chemical_list: D009602:Nitrosamines; D012906:Smoke