Bilateral testicular neuroblastoma. Scintigraphic depiction and therapy with I-131 MIBG.
The authors describe a 29-year-old man who had a 16-year history of neuroblastoma and uncommon manifestations. At age 13, he was diagnosed with stage III retroperitoneal ganglioneuroblastoma that was resected. Ten years later, bilateral testicular enlargement and a pelvic mass from infiltration of the neuroblastoma became palpable. Metastatic involvement was depicted with MIBG, a radiotracer that concentrates in tissues of the sympathetic nervous system. Using I-131 MIBG, the tumors were treated with therapeutic doses of radiation and a partial response was obtained. This case is unique because of the massive degree of bilateral testicular infiltration and its occurrence as a late manifestation of neuroblastoma in early adulthood.
Shulkin
B L
BL
Division of Nuclear Medicine, University of Michigan Medical Center, Ann Arbor 48109-0229.
Geatti
O
O
Hattner
R S
RS
Ablin
A R
AR
Hutchinson
R J
RJ
Shapiro
B
B
D019797:3-Iodobenzylguanidine; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005729:Ganglioneuroma / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000556:secondary*; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D007462:Iodobenzenes / Q000627:therapeutic use*; D008297:Male; D010386:Pelvic Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000556:secondary*; D011877:Radionuclide Imaging; D012186:Retroperitoneal Neoplasms / Q000473:pathology / Q000601:surgery*; D013736:Testicular Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000556:secondary*
D000970:Antineoplastic Agents; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine