[Conformational aspects of the biological effect of functional fragments of the p21ras oncoprotein family. 2. Fragment 1-16, various sequences].
The conformational analysis data on active ([Val12-Gly13], [Asp12-Gly13] and [Gly12-Asp13]) and passive ([Gly12-Gly13] and [Pro12-Gly13]) modifications of the p21ras family oncoproteins are presented. The activating amino acid substitutions are shown to be accompanied by essential changes in the secondary structure, resulted in the 9-16 fragment spiralization. The spatial structure of the 1-9 fragment does not vary for all the predominant forms of the active and passive analogues. The results of the conformational analysis have been used for studying the structural-functional relationships.
Mzareulov
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D000596:Amino Acids / Q000737:chemistry; D015689:Oncogene Protein p21(ras) / Q000737:chemistry*; D010446:Peptide Fragments / Q000737:chemistry*; D011487:Protein Conformation; D013329:Structure-Activity Relationship
D000596:Amino Acids; D010446:Peptide Fragments; D015689:Oncogene Protein p21(ras)
Konformatsionnye aspekty biologicheskogo deĭstviia funktsional'nykh fragmentov onkobelkov semeĭstva p21ras. 2. Fragment 1-16, razlichnye posledovatel'nosti.