Transplantation effects of a unique major histocompatibility complex class I mutation.
This study describes a novel MHC class I mouse mutant that was discovered because of loss of reactivity of its cells to monoclonal antibodies. The mutation occurred in the H-2Ks molecule and is the first in vivo mutation described that has a single altered amino acid residue (amino acid 107) distant from the regions considered to be peptide or TCR contacts. Nevertheless, skin grafts from the mutant to the parent are rejected by CD8+ T-cells. In the reciprocal direction, the mutant shows partial tolerance to parental skin grafts, suggesting that the mutant is inefficient in selecting alloreactive T-cells specific for the wild-type Ks molecule.
Hasenkrug
K J
KJ
Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461.
Stimpfling
J H
JH
Winn
H J
HJ
Nathenson
S G
SG
D000818:Animals; D003602:Cytotoxicity, Immunologic; D005805:Genes, MHC Class I; D006183:H-2 Antigens / Q000235:genetics* / Q000276:immunology; D007108:Immune Tolerance; D007111:Immunity, Cellular; D051379:Mice; D009154:Mutation; D016038:Skin Transplantation / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D006183:H-2 Antigens