title: Accelerated cardiac growth and abnormal cardiac flow in fetuses of type I diabetic mothers.
abstract: OBJECTIVE
  To determine the growth patterns of the fetal heart and the development of cardiac function during gestation in fetuses of diabetic mothers, and to compare these findings with those of normal fetuses.
  
  
  METHODS
  Serial M-mode and Doppler echocardiographic recordings were made at 4-week intervals in 14 fetuses of well-controlled type I insulin-dependent diabetic mothers and in ten control fetuses at 20-36 weeks' gestation. The following variables were measured: interventricular septal thickness, left ventricular wall thickness, right ventricular wall thickness, ratio between the peak velocities during early passive ventricular filling and active atrial filling at the level of the atrioventricular valves, peak velocities, and time to peak velocity at the level of the ascending aorta and pulmonary artery.
  
  
  RESULTS
  In both groups of fetuses, all of the indices increased linearly with gestation. However, fetuses of diabetic mothers showed significant differences in the slope and intercept values for the function describing the growth of the interventricular septum (P less than or equal to .001) and the right and left ventricular wall thicknesses (P less than or equal to .01), resulting in accelerated cardiac growth. The function describing the development of the ratios between early and active ventricular filling showed differences in slope and intercept values at the level of both the mitral (P less than or equal to .001) and tricuspid valves (P less than or equal to .001), resulting in a lower rate of increase during diabetic pregnancy when compared with control fetuses. Significantly higher intercept values were found in the functions describing the increase of peak velocities in the aorta and pulmonary artery in fetuses of diabetic mothers (P less than or equal to .01), whereas the slopes were similar to those of control fetuses. No differences were found in the time to peak values between the groups of fetuses. No relationships were found between the echocardiographic results and the metabolic control of pregnancy or fetal characteristics.
  
  
  CONCLUSIONS
  This study suggests that strict maternal diabetes control does not exclude accelerated fetal cardiac growth and abnormal development of cardiac function.
authors.affiliation: Department of Obstetrics and Gynecology, Università Cattolica S. Cuore, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Rizzo
authors.forename: D
authors.initials: D
authors.lastname: Arduini
authors.forename: C
authors.initials: C
authors.lastname: Romanini
mesh_terms: D000328:Adult; D002312:Cardiomyopathy, Hypertrophic / Q000151:congenital* / Q000000981:diagnostic imaging; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D004452:Echocardiography; D015150:Echocardiography, Doppler; D005260:Female; D005318:Fetal Heart / Q000000981:diagnostic imaging / Q000254:growth & development*; D006801:Humans; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000503:physiopathology*; D011446:Prospective Studies