Repeated administration of triiodothyronine enhances the susceptibility of rats to isoniazid- and picrotoxin-induced seizures.
In an experimental condition of hyperthyroidism, obtained by repeated administration of triiodothyronine in adult rats (100 micrograms/kg/day, sc for 7 consecutive days), there is an increased susceptibility to the convulsant effect of isoniazid (300 mg/kg, ip) and picrotoxin (4 mg/kg, ip). On the other hand, the characteristics of brain [3H] flunitrazepam binding sites are not modified. These data afford further experimental evidence of the influence of thyroid hormones on brain function.
Sandrini
M
M
Institute of Pharmacology, University of Modena, Italy.
Marrama
D
D
Vergoni
A V
AV
Bertolini
A
A
D000818:Animals; D001665:Binding Sites; D002540:Cerebral Cortex / Q000378:metabolism; D005445:Flunitrazepam / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D006980:Hyperthyroidism / Q000150:complications*; D007538:Isoniazid / Q000633:toxicity*; D008297:Male; D010852:Picrotoxin / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced*; D014284:Triiodothyronine / Q000494:pharmacology*
D005445:Flunitrazepam; D007538:Isoniazid; D010852:Picrotoxin; D014284:Triiodothyronine