title: Dose fractionation of radiolabeled antibodies in patients with metastatic colon cancer.
abstract: Twelve patients with metastatic colon cancer were treated with 131I-chimeric B72.3 (IgG-4) at total doses of 28 or 36 mCi/m2 in two or three weekly fractions. Bone marrow suppression was the only significant side effect. The degree of bone marrow suppression adjusted for whole-body dose was modestly but statistically significantly (p = 0.04) less than that seen with identical doses given as a single infusion for the total dose of 36 mCi/m2. Nine of twelve patients developed an antibody response to ch B72.3, which altered the kinetics of radiolabeled antibody in four patients given a second course of therapy. One patient had a minor response that lasted 4 mo. Fractionation of this particular radiolabeled antibody at the dose schedule used produced a modest increase in the therapeutic window in regard to administered dose.
authors.affiliation: Department of Radiation Oncology, University of Alabama, Birmingham 35294-3300.
authors.forename: R F
authors.initials: RF
authors.lastname: Meredith
authors.forename: M B
authors.initials: MB
authors.lastname: Khazaeli
authors.forename: T
authors.initials: T
authors.lastname: Liu
authors.forename: G
authors.initials: G
authors.lastname: Plott
authors.forename: R H
authors.initials: RH
authors.lastname: Wheeler
authors.forename: C
authors.initials: C
authors.lastname: Russell
authors.forename: D
authors.initials: D
authors.lastname: Colcher
authors.forename: J
authors.initials: J
authors.lastname: Schlom
authors.forename: D
authors.initials: D
authors.lastname: Shochat
authors.forename: A F
authors.initials: AF
authors.lastname: LoBuglio
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology; D000917:Antibody Formation; D001855:Bone Marrow Diseases / Q000209:etiology; D003110:Colonic Neoplasms / Q000097:blood / Q000276:immunology / Q000532:radiotherapy*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010976:Platelet Count; D016499:Radioimmunotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage
chemical_list: D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes