[Long-term sedation with propofol in ICU: hemocoagulation problems].
The Authors have studied the effects of propofol on coagulation in 15 patients admitted to ICU. Propofol was used for long-term sedation (therapeutic range 3 mg/kg/h). Variables monitored included: platelets, PTT, PT, Fibrinogen, FDP, AT III. The effects on coagulation has been investigated in three groups of patients: group I) 5 patients that received propofol for 1-3 days; group II) 5 patients that received propofol for 4-10 days; group III) 5 patients that received propofol for 11-35 days. No difference were found about blood coagulation in this groups of patients before and after administration of propofol.
Niccolai
I
I
U.O. Anestesia e Rianimazione, USSL 8, Pistoia.
Barontini
L
L
Paolini
P
P
Lavacchi
L
L
Bracciotti
G
G
Pellegrini
F
F
Aiardi
F
F
Ferlito
A
A
D000328:Adult; D000368:Aged; D001778:Blood Coagulation Disorders / Q000139:chemically induced*; D016292:Procedural Sedation; D003422:Critical Care; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000009:adverse effects*; D013997:Time Factors
D015742:Propofol
Sedazione di lunga durata con propofol in ICU: problemi emocoagulativi.