title: Epidemiology of AIDS in females with hemophilia and other chronic bleeding disorders in the United States: comparisons with males with chronic bleeding disorders and AIDS and with nonhemophilic female blood-transfusion recipients with AIDS.
abstract: From January 1, 1981 through June 30, 1990, 32 females with chronic bleeding disorders were diagnosed with acquired immunodeficiency syndrome (AIDS) in the United States. Most (81.3%) were white and greater than or equal to 30 years of age, with a median age of 37.5 years. Eighteen (56.3%) had von Willebrand's disease. Pneumocystis carinii pneumonia was reported for 16 (50%). None had Kaposi sarcoma. The median survival time was 10.8 months, with a cumulative probability of survival at 1 year of 47.3% and at 2 years of 27.6%. We compared the demographic data and survival times of these females with those of males with a chronic bleeding disorder and AIDS, and with those of nonhemophilic females with AIDS whose exposure to the human immunodeficiency virus (HIV) was through receipt of blood transfusions, blood components, or tissue. The principal demographic difference was age distribution. The females with chronic bleeding disorders tended to be younger than the transfused, nonhemophilic females, but older than the males. The survival time from AIDS diagnosis to death for the females with chronic bleeding disorders did not differ statistically from that of the other two groups, although older nonhemophilic females whose exposure was transfusion may progress more rapidly to AIDS.
authors.affiliation: Division of Immunologic, Oncologic, and Hematologic Diseases, Centers for Disease Control, Atlanta, GA 30333.
authors.forename: R C
authors.initials: RC
authors.lastname: Holman
authors.forename: T L
authors.initials: TL
authors.lastname: Chorba
authors.forename: M J
authors.initials: MJ
authors.lastname: Clarke
authors.forename: B L
authors.initials: BL
authors.lastname: Evatt
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000453:epidemiology* / Q000209:etiology; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D006467:Hemophilia A / Q000150:complications* / Q000453:epidemiology / Q000401:mortality; D006470:Hemorrhage / Q000150:complications* / Q000453:epidemiology / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D013223:Statistics as Topic; D065227:Transfusion Reaction; D014481:United States