A comparative study on the effect of verapamil and prazosin on the thermoregulatory responses induced by cold or exogenous noradrenaline.
1. Thermoregulatory responses to verapamil (VER; 5 mg/kg/hr) and prazosin (PRA; 0.75 mg/kg/3 hr) were investigated in rabbits exposed to cold (4 degrees C) and compared with those observed after treatment with noradrenaline (NA; 1.2 mg/kg/2 hr) under thermoneutral conditions (21 degrees C). 2. Both drugs abolished the thermogenic response to cold. 3. In the case of NA hyperthermia, only PRA was effective, i.e. the drug inhibited the thermal, metabolic and vasoconstricting actions of this amine. 4. Possible mechanisms, responsible for the thermoregulatory activity of both drugs are being discussed.
Gagało
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IT
Department of Pharmacology, Medical Academy, Gdańsk, Poland.
Hać
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EE
Szreder
Z
Z
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D003080:Cold Temperature; D005260:Female; D008297:Male; D009638:Norepinephrine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011224:Prazosin / Q000494:pharmacology*; D011817:Rabbits; D014700:Verapamil / Q000494:pharmacology*
D014700:Verapamil; D009638:Norepinephrine; D011224:Prazosin