title: A pneumococcal clinical isolate with high-level resistance to cefotaxime and ceftriaxone.
abstract: A beta-lactam-resistant serotype 23F Streptococcus pneumoniae clinical isolate from the cerebrospinal fluid of a pediatric patient from California is unusual in that the MICs of cefotaxime and ceftriaxone (2.5 micrograms/ml each) are higher than that of benzylpenicillin (0.3 micrograms/ml); the isolate also has patterns of penicillin-binding proteins and of cell wall peptides which are atypical compared with those of previously examined penicillin-resistant pneumococci.
authors.affiliation: Rockefeller University, New York, New York 10021-6399.
authors.forename: A M
authors.initials: AM
authors.lastname: Figueiredo
authors.forename: J D
authors.initials: JD
authors.lastname: Connor
authors.forename: A
authors.initials: A
authors.lastname: Severin
authors.forename: M V
authors.initials: MV
authors.lastname: Vaz Pato
authors.forename: A
authors.initials: A
authors.lastname: Tomasz
mesh_terms: D002439:Cefotaxime / Q000494:pharmacology*; D002443:Ceftriaxone / Q000494:pharmacology*; D002555:Cerebrospinal Fluid / Q000382:microbiology; D004352:Drug Resistance, Microbial; D006801:Humans; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D010406:Penicillins; D002443:Ceftriaxone; D002439:Cefotaxime