Production and biological activities of a new antifungal antibiotic, TAN-950 A.
A novel antifungal antibiotic, TAN-950 complex, was isolated from the culture filtrate of Streptomyces platensis A-136 (IFO 14603, FERM BP-1786). The water-soluble amphoteric substances in this complex were purified by chromatography using ion-exchange resins, QAE-Sephadex and adsorptive resins and were designated TAN-950 A and TAN-950 A-E mixture. The molecular formula of TAN-950 A was determined to be C6H7N2O4Na for the sodium salt. This new amino acid antibiotic showed antifungal activity against Candida albicans in vitro and in vivo, and had low toxicity in mice.
Hakoda
S
S
Research and Development Division, Takeda Chemical Ind. Ltd., Osaka, Japan.
Tsubotani
S
S
Iwasa
T
T
Suzuki
M
M
Kondo
M
M
Harada
S
S
D000818:Animals; D000935:Antifungal Agents / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D005260:Female; D005285:Fermentation; D007555:Isoxazoles / Q000302:isolation & purification / Q000494:pharmacology; D051379:Mice; D013302:Streptomyces / Q000145:classification / Q000378:metabolism
D000935:Antifungal Agents; D007555:Isoxazoles; C071084:2-amino-3-(2,5-dihydro-5-oxo-4-isoxazolyl)propanoic acid