Biological activity of prostaglandin E3 with regard to oedema formation in mice.
The biological activity of PGE3 with regard to oedema formation in mice was examined. Paw swelling was measured 30 minutes after injection of 10 microliters PGE2 or PGE3 into the plantar region of the hind paw. Doses investigated ranged from 1 ng-10 micrograms. Both PGE2 and PGE3 had substantial oedemogenic activity in this system.
Hawkes
J S
JS
Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Australia.
James
M J
MJ
Cleland
L G
LG
D000527:Alprostadil / Q000031:analogs & derivatives* / Q000633:toxicity; D000818:Animals; D015232:Dinoprostone / Q000633:toxicity; D004487:Edema / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D005528:Foot; D051379:Mice
C033246:prostaglandin E3; D000527:Alprostadil; D015232:Dinoprostone