[The possibilities for the early diagnosis of ankylosing spondylarthritis].
Soluble antigen HLA-B27 was assayed in blood serum of 30 patients afflicted with ankylosing spondyloarthritis (AS) and 25 healthy subjects having HLA-B27 (B27+) antigen in the phenotype. As compared to B27+ healthy subjects, B27+ patients with AS demonstrated a significantly higher level of soluble HLA-B27 antigen. A substance whose functional activity was found to be identical to that of soluble HLA-B27 antigen in blood serum of B27- patients with AS was discovered for the first time. It was absent from B27- healthy subjects. In addition to the identification of the fixed forms of soluble HLA-B27 antigen, the assay of this antigen in blood serum enhances the potentialities of laboratory diagnosis of AS, which plays an important role at the early disease stages.
Matveĭkov
G P
GP
Levin
V I
VI
Titova
I P
IP
Kaliia
E S
ES
Soloveĭ
A N
AN
Atamanenko
L G
LG
D000328:Adult; D002908:Chronic Disease; D005260:Female; D015796:HLA-B27 Antigen / Q000097:blood; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012995:Solubility; D013167:Spondylitis, Ankylosing / Q000175:diagnosis*; D013997:Time Factors
D015796:HLA-B27 Antigen
Vozmozhnosti ranneĭ diagnostiki ankiloziruiushchego spondiloartrita.