title: Use of zinc acetate to treat copper toxicosis in dogs.
abstract: Zinc acetate was used for the treatment and prophylaxis of hepatic copper toxicosis in 3 Bedlington Terriers and 3 West Highland White Terriers. Two dogs of each breed were treated for 2 years, and 1 of each breed for 1 year. A dosage of 200 mg of elemental zinc per day was required to achieve therapeutic objectives related to copper, which included a doubling of plasma zinc concentration to 200 micrograms/dl and a suppression of oral 64 copper absorption. The dosage was later reduced to 50 to 100 mg/day to avoid an excessive increase in plasma zinc concentration. The preliminary clinical results were good. Three dogs had mild to moderate active liver disease and high liver copper concentrations at the time of initiation of zinc administration. Biopsy of the liver 2 years later revealed a reduction in hepatitis and copper concentrations. One other dog without active hepatitis also had a reduction in hepatic copper concentrations over a 2-year period. All 6 dogs have done well clinically. On the basis of these findings, we believe zinc acetate to be an effective and nontoxic treatment for copper toxicosis in dogs.
authors.affiliation: Department of Human Genetics, University of Michigan, Ann Arbor 48109-0618.
authors.forename: G J
authors.initials: GJ
authors.lastname: Brewer
authors.forename: R D
authors.initials: RD
authors.lastname: Dick
authors.forename: W
authors.initials: W
authors.lastname: Schall
authors.forename: V
authors.initials: V
authors.lastname: Yuzbasiyan-Gurkan
authors.forename: T P
authors.initials: TP
authors.lastname: Mullaney
authors.forename: C
authors.initials: C
authors.lastname: Pace
authors.forename: J
authors.initials: J
authors.lastname: Lindgren
authors.forename: M
authors.initials: M
authors.lastname: Thomas
authors.forename: G
authors.initials: G
authors.lastname: Padgett
mesh_terms: D000042:Absorption / Q000187:drug effects; D000085:Acetates / Q000627:therapeutic use*; D019342:Acetic Acid; D000818:Animals; D001947:Breeding; D056486:Chemical and Drug Induced Liver Injury; D003300:Copper / Q000032:analysis / Q000493:pharmacokinetics / Q000506:poisoning*; D004283:Dog Diseases / Q000139:chemically induced* / Q000188:drug therapy / Q000517:prevention & control; D004285:Dogs; D008099:Liver / Q000737:chemistry; D008107:Liver Diseases / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D011041:Poisoning / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary; D015032:Zinc / Q000097:blood
chemical_list: D000085:Acetates; D003300:Copper; D015032:Zinc; D019342:Acetic Acid