title: Effect of continuous circular capsulorhexis and intraocular lens fixation on the blood-aqueous barrier.
abstract: Permeability across the blood-aqueous barrier to fluorescein was estimated fluorophotometrically in pseudophakic eyes for which a continuous circular capsulorhexis was performed. The permeability index was significantly higher in the in-the-bag fixations than in the out-of-the-bag fixations at 3 and 6 months after surgery, when only bilateral cases were enrolled. Damage to the barrier in eyes with the in-the-bag fixations was attributable to the broad attachment of optics to the anterior capsule, because a positive linear regression was obtained between the permeability index and the doughnut-shaped contact area in eyes with the in-the-bag fixations. The permeability index in eyes with the in-the-bag fixations was as low as that in eyes with the out-of-the-bag fixations when the contact area was small. These results indicate an unfavorable effect of the in-the-bag fixation with broad contact of the optics with the anterior capsule and, thus, suggest either an in-the-bag fixation with a large capsulorhexis or an out-of-the-bag fixation.
authors.affiliation: Institute of Ophthalmology, Tane Memorial Eye Hospital, Osaka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Tsuboi
authors.forename: M
authors.initials: M
authors.lastname: Tsujioka
authors.forename: T
authors.initials: T
authors.lastname: Kusube
authors.forename: S
authors.initials: S
authors.lastname: Kojima
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001082:Aqueous Humor / Q000378:metabolism*; D001769:Blood / Q000378:metabolism*; D019793:Fluorescein; D005452:Fluoresceins; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000293:injuries*; D007910:Lenses, Intraocular; D008875:Middle Aged; D010539:Permeability; D011446:Prospective Studies; D012044:Regression Analysis; D012421:Rupture / Q000209:etiology
chemical_list: D005452:Fluoresceins; D019793:Fluorescein