title: VDJ recombination.
abstract: The ability of lymphocyte receptor V, D and J gene segments to rearrange generates much of the receptor diversity that is the hallmark of the immune system. Naturally, the mechanisms of immunoglobulin and T-cell receptor gene recombination are of enormous interest. Here, Fred Alt and colleagues review current understanding of the process and speculate on future findings.
authors.forename: F W
authors.initials: FW
authors.lastname: Alt
authors.forename: E M
authors.initials: EM
authors.lastname: Oltz
authors.forename: F
authors.initials: F
authors.lastname: Young
authors.forename: J
authors.initials: J
authors.lastname: Gorman
authors.forename: G
authors.initials: G
authors.lastname: Taccioli
authors.forename: J
authors.initials: J
authors.lastname: Chen
mesh_terms: D000818:Animals; D004254:DNA Nucleotidyltransferases / Q000235:genetics*; D015329:Gene Rearrangement, T-Lymphocyte / Q000235:genetics; D005803:Genes, Immunoglobulin; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D011995:Recombination, Genetic; D013379:Substrate Specificity; D045567:VDJ Recombinases
chemical_list: D011948:Receptors, Antigen, T-Cell; D004254:DNA Nucleotidyltransferases; D045567:VDJ Recombinases