[Granulocyte alkaline phosphatase activity in the chronic phase and blastic crisis of chronic myeloid leukemia. Sequential study of 43 patients].
OBJECTIVE
To evaluate in a sequential fashion the activity of the leukocyte alkaline phosphatase (LAP) in the chronic phase and the blastic crisis of chronic myelogenous leukaemia (CML).


METHODS
This study is comprised of 43 patients diagnosed of CML according to standard criteria. The initial LAP scores were compared with those recorded in the blastic crisis, using cytochemical methods. The statistical analysis was performed with Student's test and chi-square.


RESULTS
The LAP activity at diagnosis was low in 40 of the 43 cases (93%), the score being 0 in 20 instances. In the blastic crisis low scores were found in 27 patients (63%), while LAP activity appeared normal or increased in 16 others (37%). When the LAP scores of the two phases of the disease were compared the differences were found statistically significant (p less than 0.0001 and p less than 0.0007, respectively).


CONCLUSIONS
These results confirm that the onset of the blastic crisis of CML is often accompanied by an increase of the LAP activity, although this last persists low in the majority of the patients.
Bosch
F
F
Servicio de Hematología Clínica, Escuela de Hematología Farreras Valenti, Hospital Clínico y Provincial, Universidad de Barcelona.
Cervantes
F
F
Rozman
M
M
Terol
M J
MJ
Montserrat
E
E
Rozman
C
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000378:metabolism*; D001752:Blast Crisis / Q000201:enzymology*; D005260:Female; D006098:Granulocytes / Q000201:enzymology*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000201:enzymology* / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged
D000469:Alkaline Phosphatase
Actividad de fosfatasa alcalina granulocitaria en la fase crónica y crisis blástica de la leucemia mieloide crónica. Estudio secuencial en 43 pacientes.