title: Serum tumor necrosis factor activity in inflammatory bowel disease.
abstract: Serum tumor necrosis factor (TNF) levels in 33 patients with inflammatory bowel disease (IBD) were measured by using a sensitive enzyme immunoassay. Four of five Crohn's diseases (CD) and nine of twenty eight ulcerative colitis (UC) had elevated levels of serum TNF. In active CD or UC, a greater fraction of patients studied had significantly increased serum TNF levels (3/3 for CD and 8/11 for UC). Production of TNF by peripheral blood monocytes when stimulated by lipopolysaccharide was also increased in these patients and correlated with their serum TNF levels. These results suggest that TNF may have some pathoetiological meaning in IBD.
authors.affiliation: Department of Internal Medicine (Section 4), Sapporo Medical College, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Maeda
authors.forename: N
authors.initials: N
authors.lastname: Watanabe
authors.forename: H
authors.initials: H
authors.lastname: Neda
authors.forename: N
authors.initials: N
authors.lastname: Yamauchi
authors.forename: T
authors.initials: T
authors.lastname: Okamoto
authors.forename: H
authors.initials: H
authors.lastname: Sasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Tsuji
authors.forename: S
authors.initials: S
authors.lastname: Akiyama
authors.forename: N
authors.initials: N
authors.lastname: Tsuji
authors.forename: Y
authors.initials: Y
authors.lastname: Niitsu
mesh_terms: D000328:Adult; D003093:Colitis, Ulcerative / Q000097:blood / Q000276:immunology; D003424:Crohn Disease / Q000097:blood / Q000276:immunology; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000097:blood* / Q000209:etiology / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D014409:Tumor Necrosis Factor-alpha