title: Studies on viridenomycin, a novel 24-membered macrocyclic polyene lactam antibiotic.
abstract: A new antitumor antibiotic, designated AL081, was obtained from the culture filtrate of an actinomycete identified as Streptomyces gannmycicus, and found to be identical with viridenomycin by direct comparison. The structure of the antibiotic was determined by NMR spectral analysis including a variety of two-dimensional techniques to be a novel 24-membered macrocyclic polyene lactam. Viridenomycin prolonged the survival periods of mice bearing P388 leukemia and B16 melanoma cells.
authors.affiliation: Pharmaceutical Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Y
authors.initials: Y
authors.lastname: Toda
authors.forename: K
authors.initials: K
authors.lastname: Furihata
authors.forename: Y
authors.initials: Y
authors.lastname: Hayakawa
authors.forename: H
authors.initials: H
authors.lastname: Seto
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002965:Classification; D007769:Lactams / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008854:Microscopy, Electron; D013302:Streptomyces / Q000145:classification; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D007769:Lactams; C010374:viridinomycin