title: A trial of desmopressin to reduce blood loss in patients undergoing spinal fusion for idiopathic scoliosis.
abstract: Desmopressin (DDAVP) has been reported to reduce bleeding in patients undergoing spinal fusion. To evaluate its efficacy in normal patients, 30 healthy young patients (ASA physical status I or II) undergoing spinal fusion for idiopathic scoliosis were randomly allocated to receive either 100 mL of physiologic saline solution (placebo group) or DDAVP (10 micrograms/m2 of body surface area) (DDAVP group) in a prospective, double-blind trial. Intraoperative blood loss was measured by weighing sponges and suction drainage and postoperative bleeding by wound drainage. The amount of blood loss expressed as a percent of the estimated blood volume was similar in both groups during the intraoperative period (67.0% +/- 28.8% [mean +/- SD] placebo group vs 57.4% +/- 26.5% DDAVP group), the postoperative period up to 24 h (32.5% +/- 6.4% placebo group vs 31.1% +/- 10.6% DDAVP group), and both periods (94.3% +/- 29.4% placebo group vs 88.2% +/- 30.7% DDAVP group). With the dose used in our study, we conclude that DDAVP does not reduce surgical bleeding in patients undergoing spinal fusion for idiopathic scoliosis.
authors.affiliation: Department of Anesthesiology, Sainte-Justine Hospital, Montreal, Quebec, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Guay
authors.forename: C
authors.initials: C
authors.lastname: Reinberg
authors.forename: B
authors.initials: B
authors.lastname: Poitras
authors.forename: M
authors.initials: M
authors.lastname: David
authors.forename: S
authors.initials: S
authors.lastname: Mathews
authors.forename: L
authors.initials: L
authors.lastname: Lortie
authors.forename: G E
authors.initials: GE
authors.lastname: Rivard
mesh_terms: D000293:Adolescent; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use*; D005169:Factor VIII / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D012600:Scoliosis / Q000209:etiology / Q000601:surgery*; D013123:Spinal Fusion / Q000009:adverse effects*; D014841:von Willebrand Factor / Q000187:drug effects / Q000378:metabolism
chemical_list: D014841:von Willebrand Factor; D005169:Factor VIII; D003894:Deamino Arginine Vasopressin