title: Auditory event-related potentials in HIV-1 infection: a study in the drug-user risk group.
abstract: Features of event-related potentials (ERPs) may be sensitive and clinically useful markers of central nervous system infection by the human immunodeficiency virus (HIV-1); however, this application has not been studied in the risk group of intravenous drug users. Auditory ERPs generated by an "oddball" paradigm were analyzed for 39 male drug abusers as part of a multimodal assessment. Stage of HIV-1 infection was associated with prolongations of P1, N1, and P3 components of the ERP waveform. Only patients with full acquired immunodeficiency syndrome showed statistically significant increases in waveform prolongations. Specific neuropsychological deficits were not related to waveform latency prolongations.
authors.affiliation: Psychiatry, Service, Veterans Affairs Medical Center, Bronx, NY 10468.
authors.forename: L
authors.initials: L
authors.lastname: Handelsman
authors.forename: T
authors.initials: T
authors.lastname: Horvath
authors.forename: M
authors.initials: M
authors.lastname: Aronson
authors.forename: M
authors.initials: M
authors.lastname: Schroeder
authors.forename: J
authors.initials: J
authors.lastname: Jacobson
authors.forename: J
authors.initials: J
authors.lastname: Wiener
authors.forename: A
authors.initials: A
authors.lastname: Peterson
authors.forename: K
authors.initials: K
authors.lastname: Holloway
authors.forename: R
authors.initials: R
authors.lastname: Ness
authors.forename: S
authors.initials: S
authors.lastname: Herman
mesh_terms: D015526:AIDS Dementia Complex / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D000328:Adult; D001933:Brain Stem / Q000503:physiopathology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D006679:HIV Seropositivity / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D015497:HIV-1 / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D008691:Methadone / Q000627:therapeutic use; D009483:Neuropsychological Tests; D009293:Opioid-Related Disorders / Q000503:physiopathology* / Q000523:psychology / Q000534:rehabilitation; D011930:Reaction Time / Q000502:physiology; D015819:Substance Abuse, Intravenous / Q000503:physiopathology* / Q000523:psychology / Q000534:rehabilitation
chemical_list: D008691:Methadone