Probucol attenuates a reduction in serum immunoreactive insulin levels by interleukin in adrenalectomized rats.
We determined a protective action of probucol (4,4'-[isopropylidenedithio]bis[2,6-di-tert-butylphenol]) on the reduction of serum immunoreactive insulin (IRI) levels by recombinant human interleukin-1 beta (IL-1) in adrenalectomized rats. IL-1 reduced the serum IRI levels 4 h after injection in rats fed a standard diet. However, IL-1 failed to inhibit serum IRI levels in rats fed a diet containing 1% probucol. In contrast, IL-1 decreased plasma glucose levels in both groups. Although IL-1 reduced plasma prostaglandin (PG) E2 levels in standard diet-fed rats, IL-1 did not affect plasma PGE2 levels in the animals fed the probucol-containing diet. The present study suggested that the free radical scavenger action of probucol can block the IL-1 effect on serum IRI levels.
Shimizu
H
H
First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.
Uehara
Y
Y
Mori
M
M
D000284:Administration, Oral; D000315:Adrenalectomy; D000704:Analysis of Variance; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D015232:Dinoprostone / Q000097:blood; D007328:Insulin / Q000097:blood*; D007375:Interleukin-1 / Q000494:pharmacology*; D008297:Male; D011341:Probucol / Q000008:administration & dosage / Q000494:pharmacology*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000494:pharmacology
D001786:Blood Glucose; D007328:Insulin; D007375:Interleukin-1; D011994:Recombinant Proteins; D015232:Dinoprostone; D011341:Probucol