Biostatistical evaluation of blood group, HLA and DNA findings in Jeffreys' immigrant test-case using special kinship and DNA algorithms.
In the immigration case cited by Jeffreys et al. (1985), the biostatistical evaluation of blood group findings in 16 systems and of HLA-A,B findings for the mother and child, using a special kinship algorithm developed by Ihm and Hummel (1975), produced a probability of maternity of the Ghanaian-born putative mother of W = 6%; the probability of maternity for her sister was W = 94%. Using the DNA multilocus probes 33.15 and 33.6 and the bandsharing technique, the authors analysed band patterns from the putative mother and child as well as another 3 children of the same woman. It was concluded that the putative mother was the mother of all 4 children. An evaluation of the band patterns using the multi-di-allelism model and the kinship algorithm in accordance with the Essen-Möller principle produced: W = 99.99999999999999991%, or, if the "-----" constellations were not considered, W = 99.99998%.
Hummel
K
K
Institut für Blutgruppenserologie, Freiburg, Federal Republic of Germany.
D000328:Adult; D000465:Algorithms; D001788:Blood Grouping and Crossmatching / Q000706:statistics & numerical data*; D002648:Child; D004247:DNA / Q000235:genetics*; D004641:Emigration and Immigration; D005260:Female; D005828:Genetics, Population; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D008957:Models, Genetic; D015233:Models, Statistical; D010375:Pedigree; D010641:Phenotype
D006680:HLA Antigens; D004247:DNA