title: Inherited neuroaxonal dystrophy in C6 deficient rabbits.
abstract: We report the occurrence of a progressive neurological syndrome clinically characterized by subacute motor neuropathy in offspring of C6 deficient rabbits. On the basis of the pedigree analysis, the disease appears to be genetically transmitted, most probably with an autosomal recessive mode of inheritance. Pathological studies of affected animals revealed: transmitted, most probably with an autosomal recessive mode of inheritance. Pathological studies of affected animals revealed: 1) severe axonal degeneration in the sciatic nerve system involving mainly motor fibers; 2) occasional peripheral axonal enlargement closely associated with axonal degeneration; 3) presence of structured abnormal material in normal-size myelinated fibers of central nervous system (CNS) and peripheral nervous system (PNS); and 4) widespread occurrence of dystrophic axons and axonal spheroids in the gray matter of CNS. By ultrastructural examination, dystrophic axons are filled with tubulovesicular material, stalks of parallel membranes and dense bodies similar to what is described in human neuroaxonal dystrophies (NAD). The disease manifested by C6 deficient rabbits may represent an animal model of primary human NAD.
authors.affiliation: Institute of Neurology, University of Verona, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Giannini
authors.forename: S
authors.initials: S
authors.lastname: Monaco
authors.forename: M
authors.initials: M
authors.lastname: Kirschfink
authors.forename: K O
authors.initials: KO
authors.lastname: Rother
authors.forename: H
authors.initials: H
authors.lastname: Lorbacher de Ruiz
authors.forename: E
authors.initials: E
authors.lastname: Nardelli
authors.forename: B
authors.initials: B
authors.lastname: Bonetti
authors.forename: A
authors.initials: A
authors.lastname: Salviati
authors.forename: G P
authors.initials: GP
authors.lastname: Zanette
authors.forename: N
authors.initials: N
authors.lastname: Rizzuto
mesh_terms: D000818:Animals; D001369:Axons / Q000648:ultrastructure*; D002490:Central Nervous System / Q000473:pathology; D003183:Complement C6 / Q000172:deficiency*; D004594:Electrophysiology; D005260:Female; D008297:Male; D008854:Microscopy, Electron; D009046:Motor Neurons / Q000473:pathology*; D009410:Nerve Degeneration; D009422:Nervous System Diseases / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D010375:Pedigree; D010525:Peripheral Nerves / Q000473:pathology; D011817:Rabbits
chemical_list: D003183:Complement C6