Embryotoxicity of 25 psychotropic drugs: a study using CHEST.
Twenty five psychotropic drugs were ranked according to the embryotoxicity dose ranges estimated by the Chick Embryotoxicity Screening Test (CHEST). The chick results were compared with some data for common laboratory mammals. In 17 psychotropic drugs a deleterious dose-dependent effect upon the embryonic cardiovascular system was disclosed, terminating in immediate cardiac arrest.
Peterka
M
M
Institute of Experimental Medicine, Czechoslovak Academy of Sciences, Praha.
Jelínek
R
R
Pavlík
A
A
D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects; D002642:Chick Embryo; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D006323:Heart Arrest / Q000139:chemically induced / Q000503:physiopathology; D051379:Mice; D011247:Pregnancy; D011619:Psychotropic Drugs / Q000633:toxicity*; D011817:Rabbits; D051381:Rats; D013723:Teratogens / Q000633:toxicity*
D011619:Psychotropic Drugs; D013723:Teratogens