Leualacin, a novel calcium blocker from Hapsidospora irregularis. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties.
A new calcium blocker, designated leualacin, has been isolated from Hapsidospora irregularis. The compound inhibits the binding of 3H-nitrendipine, a well known synthetic calcium blocker, to cardiac Ca channel in a competitive manner, although its structure is completely different from dihydropyridines.
Hamano
K
K
Fermentation Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
Kinoshita
M
M
Furuya
K
K
Miyamoto
M
M
Takamatsu
Y
Y
Hemmi
A
A
Tanzawa
K
K
D000818:Animals; D002121:Calcium Channel Blockers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D005658:Fungi / Q000145:classification* / Q000378:metabolism; D006168:Guinea Pigs; D008297:Male; D010456:Peptides, Cyclic / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D047630:Depsipeptides
D002121:Calcium Channel Blockers; D010456:Peptides, Cyclic; C076086:leualacin; D047630:Depsipeptides