title: Serum triglyceride and insulin levels are associated with erythrocyte sodium-lithium counter-transport activity in normoglycaemic individuals.
abstract: The relationship between erythrocyte sodium-lithium counter-transport activity, serum insulin, lipids and demographic factors was examined in 93 normoglycaemic predominantly normotensive individuals with mild fasting hypercholesterolaemia (greater than 5.2 mmol/l). The major significant univariate correlates of sodium-lithium counter-transport activity were fasting serum triglycerides, HDL cholesterol, the ratio of fasting glucose: insulin, apo A1, alcohol consumption and apo B. Stepwise multiple regression analysis revealed 24% of the variability in sodium-lithium counter-transport activity could be accounted for by independent contributions of fasting serum triglycerides, alcohol consumption, the fasting glucose/insulin ratio and apo A1 and ANOVA confirmed a significant relationship with fasting insulin measures that was independent of serum triglycerides (P less than 0.05). The relationship between erythrocyte sodium-lithium counter-transport activity and concentrations of serum triglycerides, HDL components, insulin and additionally alcohol consumption, could reflect the influence of those variables on erythrocyte structure and function.
authors.affiliation: Department of Medicine, Medical School, University of Newcastle upon Tyne, UK.
authors.forename: P H
authors.initials: PH
authors.lastname: Winocour
authors.forename: T H
authors.initials: TH
authors.lastname: Thomas
authors.forename: L
authors.initials: L
authors.lastname: Brown
authors.forename: M F
authors.initials: MF
authors.lastname: Laker
authors.forename: R
authors.initials: R
authors.lastname: Wilkinson
authors.forename: K G
authors.initials: KG
authors.lastname: Alberti
mesh_terms: D000428:Alcohol Drinking; D017920:Antiporters; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D002352:Carrier Proteins / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism*; D005215:Fasting; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D012044:Regression Analysis; D014280:Triglycerides / Q000097:blood*
chemical_list: D017920:Antiporters; D001786:Blood Glucose; D002352:Carrier Proteins; D008076:Cholesterol, HDL; D007328:Insulin; D014280:Triglycerides; C045885:sodium-lithium countertransporter; D002784:Cholesterol