title: [Relationship between lipid metabolism disorders and age of first manifestations of coronary heart disease].
abstract: In 509 male patients, age less than 45 years, with angiographically documented coronary artery disease (CHD) we found (in contrast to age-matched controls: 459 participants of the PROCAM study) an increased amount of total cholesterol (259 vs. 221 mg/dl), LDL-cholesterol (185 vs. 142 mg/dl), Apo-B (138 vs. 118 mg/dl), lipoprotein(a) (12 vs. 5 mg/dl) and uric acid (6.4 vs. 5.8 mg/dl); HDL-cholesterol (40.5 vs. 46.8 mg/dl), Apo-A-I (122 vs. 143 mg/dl) and Apo-A-II (38 vs. 43 mg/dl) were significantly lower. These differences in lipid-metabolism between CHD-patients and controls in the younger group were essentially more pronounced than in older individuals of a group of 423 male patients over the age of 45 years who suffered from CHD and 545 age-matched PRO-CAM participants. Among the extent of the disorder in lipid metabolism, the apolipoprotein E-polymorphism, and the age of onset of CHD there exists a significant correlation which proves the special importance to therapeutically influence disorders of lipid metabolism especially in younger patients.
authors.affiliation: Salzetalklinik d. LVA Westfalen, Bad Salzuflen.
authors.forename: E
authors.initials: E
authors.lastname: Köhler
authors.forename: A
authors.initials: A
authors.lastname: Bentrup
authors.forename: H
authors.initials: H
authors.lastname: Funke
authors.forename: M
authors.initials: M
authors.lastname: Sandkamp
authors.forename: H
authors.initials: H
authors.lastname: Schulte
authors.forename: G
authors.initials: G
authors.lastname: Assmann
mesh_terms: D000328:Adult; D000367:Age Factors; D000787:Angina Pectoris / Q000097:blood / Q000000981:diagnostic imaging; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood / Q000000981:diagnostic imaging* / Q000534:rehabilitation; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000000981:diagnostic imaging* / Q000534:rehabilitation; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000000981:diagnostic imaging; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
chemical_list: D008055:Lipids
vernacular_title: Untersuchungen zur Beziehung zwischen Lipidstoffwechselstörungen und Erstmanifestationsalter der koronaren Herzkrankheit (KHK).