pH dependence of fluorescence and absorbance spectra of free sulphonated aluminium phthalocyanine and its conjugate with monoclonal antibodies.
Water-soluble phthalocyanines and phthalocyanines linked to targeting monoclonal antibodies are considered to be one of the most promising photosensitizers in photodynamic therapy. Here the spectrum characteristics of sulphonated aluminium phthalocyanine and its protein conjugate in the pH range 1.8-12.0 in solution have been studied. The pK values are determined.
Savitsky
A P
AP
A. N. Bakh Institute of Biochemistry, Russian Academy of Sciences, Moscow.
Lopatin
K V
KV
Golubeva
N A
NA
Poroshina MYu
Chernyaeva
E B
EB
Stepanova
N V
NV
Solovieva
L I
LI
Lukyanets
E A
EA
D000535:Aluminum / Q000737:chemistry*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D000922:Immunotoxins / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D051379:Mice; D009942:Organometallic Compounds / Q000737:chemistry*; D011838:Radiation-Sensitizing Agents / Q000737:chemistry*; D013050:Spectrometry, Fluorescence
D000911:Antibodies, Monoclonal; D005456:Fluorescent Dyes; D000922:Immunotoxins; D007211:Indoles; D009942:Organometallic Compounds; D011838:Radiation-Sensitizing Agents; C064331:aluminum phthalocyanine disulfonate; D000535:Aluminum