Concurrence of primary aldosteronism and renal artery stenosis.
1. An unusual clinical case is described in which renal artery stenosis (RAS) was found to coexist with adrenocortical hyperplasia, resulting in hypertension. 2. Partial relief of the hypertension was achieved by correction of RAS, and then further relief by extirpation of one adrenal gland affected by unilateral hyperplasia, in interventions 8 months apart. 3. Biochemical features typical of primary hyperaldosteronism were observed both before and after RAS repair but were not present after unilateral adrenalectomy. 4. The association of these two lesions could have occurred by chance, through genetic linkage, or by progression from RAS to tertiary aldosteronism.
Stokes
G S
GS
Hypertension Unit, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Monaghan
J C
JC
Roche
J
J
Grunstein
H
H
Gordon
R D
RD
D000302:Adrenal Cortex / Q000473:pathology; D000450:Aldosterone / Q000097:blood / Q000652:urine; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood / Q000150:complications* / Q000652:urine; D006973:Hypertension / Q000097:blood / Q000209:etiology / Q000652:urine; D008297:Male; D008875:Middle Aged; D012078:Renal Artery Obstruction / Q000097:blood / Q000150:complications* / Q000652:urine; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000502:physiology; D012964:Sodium / Q000652:urine
D000450:Aldosterone; D012964:Sodium; D012083:Renin