Antitumor activity of polysaccharide from a Chinese medicinal herb, Acanthopanax giraldii Harms.
The results of experiments with Acanthopanax giraldii polysaccharide (AGP) demonstrated that it inhibited the growth of solid Sarcoma 180 and prolonged the survival time significantly. In tumor-bearing mice, AGP enhanced the phagocytosis and chemiluminescence of macrophages. By the immunofluorescent method, binding of the third component of complement (C3) cleavage product to macrophages and proportion of C3 positive cells were increased. In crossed immunoelectrophoresis, human serum C3 was converted by AGP and appeared as the 3rd peak. The height of the 3rd peak was directly proportional to doses of AGP. The residual CH50 units of human serum decreased dose-dependently. These results suggest that the antitumor activity of AGP is related to the enhancement of immune responses.
Wang
J Z
JZ
Department of Pharmacology, Mie University School of Medicine, Japan.
Tsumura
H
H
Shimura
K
K
Ito
H
H
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003176:Complement C3 / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D008262:Macrophage Activation / Q000187:drug effects*; D051379:Mice; D008813:Mice, Inbred ICR; D009368:Neoplasm Transplantation; D010587:Phagocytosis / Q000187:drug effects; D011134:Polysaccharides / Q000494:pharmacology*; D012513:Sarcoma, Experimental / Q000276:immunology* / Q000473:pathology
D003176:Complement C3; D004365:Drugs, Chinese Herbal; D011134:Polysaccharides