Excitatory amino acids and the actions of cocaine.
Antagonists of the N-methyl-D-aspartate (NMDA) type of excitatory amino acid (EAA) receptors blocked cocaine-induced stereotypy, locomotor stimulation and convulsions. These effects in general appear to involve selectively NMDA type of receptors. The results suggest that NMDA-activated systems are an integral component in the reaction sequences involved in the expression of several behavioral effects of cocaine.
Karler
R
R
Department of Pharmacology, University of Utah School of Medicine, Salt Lake City 84132.
Calder
L D
LD
D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D003042:Cocaine / Q000494:pharmacology*; D003915:Dextromethorphan / Q000494:pharmacology; D016291:Dizocilpine Maleate / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects*; D016202:N-Methylaspartate / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D010875:Pipecolic Acids / Q000494:pharmacology; D011810:Quinoxalines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology; D013237:Stereoisomerism; D013239:Stereotyped Behavior / Q000187:drug effects*
D010875:Pipecolic Acids; D011810:Quinoxalines; D002110:Caffeine; C053672:selfotel; C056723:FG 9041; D016202:N-Methylaspartate; D016291:Dizocilpine Maleate; D003915:Dextromethorphan; D003042:Cocaine; D006220:Haloperidol