The effect of cyclosporin A (CSA) on murine visceral toxocariasis canis.
Swiss mice experimentally infected with T. canis were treated by Cyclosporin A (CSA). The direct antiparasitic effect was noticed when administered on the same day of infection and was more effective when repeated for eight weeks. Although immunosuppression of CSA increased the susceptibility of mice to T. canis larvae, its direct antiparasitic effect was more effective and led to diminution of living T. canis larvae. Cellular immunity was inhibited as revealed by diminution of T. lymphocytes by decreased lymphocytes migration inhibition percentage on repeated administration of CSA for four weeks.
el-Ganayni
G A
GA
Department of Parasitology, Faculty of Medicine, Mansoura University, Egypt.
Handousa
A E
AE
D000818:Animals; D002464:Cell Migration Inhibition; D016572:Cyclosporine / Q000494:pharmacology / Q000627:therapeutic use*; D007111:Immunity, Cellular / Q000187:drug effects; D051379:Mice; D014119:Toxocara / Q000187:drug effects; D014120:Toxocariasis / Q000188:drug therapy* / Q000276:immunology
D016572:Cyclosporine