title: Effects of Ehrlichia phagocytophila infection on serum thyroid hormone concentrations and on antipyrine clearance and metabolite formation in dwarf goats.
abstract: The influence of infection with Ehrlichia phagocytophila (EP) on serum thyroid hormone concentrations and on antipyrine (25 mg/kg of body weight, IV) plasma elimination and urinary metabolite excretion was studied in castrated male dwarf goats. Mean thyroid hormone concentrations moderately decreased in EP-infected goats, with maximal decrease in total and free triiodothyronine and thyroxine serum concentrations of 56, 64, 23, and 19%, respectively. The estimated pharmacokinetic values of antipyrine (AP) in EP-infected goats were similar to those in the goats when healthy. However, glucuronidation of the AP-metabolites 3-hydroxymethyl-AP, 4,4'-dihydroxy-AP, and 4-hydroxy-AP was reduced during the febrile episode of the acute-phase response to EP infection.
authors.affiliation: Department of Veterinary Pharmacology, Pharmacy, and Toxicology, Faculty of Veterinary Medicine, State University of Utrecht, The Netherlands.
authors.forename: V N
authors.initials: VN
authors.lastname: Offiah
authors.forename: S M
authors.initials: SM
authors.lastname: Nijmeijer
authors.forename: C T
authors.initials: CT
authors.lastname: van Duin
authors.forename: R F
authors.initials: RF
authors.lastname: Witkamp
authors.forename: A S
authors.initials: AS
authors.lastname: van Miert
mesh_terms: D000210:Acute-Phase Reaction / Q000097:blood / Q000378:metabolism / Q000662:veterinary; D000818:Animals; D000983:Antipyrine / Q000493:pharmacokinetics*; D016873:Ehrlichiosis / Q000097:blood / Q000378:metabolism / Q000662:veterinary*; D015511:Goat Diseases / Q000097:blood / Q000378:metabolism*; D006041:Goats; D008297:Male; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*
chemical_list: D014284:Triiodothyronine; D013974:Thyroxine; D000983:Antipyrine