title: Genetic and molecular analysis of recessive alleles at the pink-eyed dilution (p) locus of the mouse.
abstract: Recessive mutant alleles at the pink-eyed dilution (p) locus on mouse chromosome 7 reduce pigmentation of both the coat and eyes. Here we describe the properties and complementation interactions of 10 p alleles, including 6 not previously reported. Several alleles that cause additional phenotypes affecting development, reproduction, and behavior were shown to be deletions by using DNA probes derived from the p region. An alignment of functional and marker-defined units is proposed, giving a linear complementation map that orders at least four functional loci. The characterization of a nested set of deletions around p will facilitate detailed molecular analyses of the genes and developmental functions associated with this part of the mouse genome.
authors.affiliation: Medical Research Council Radiobiology Unit, Didcot, Oxon, England.
authors.forename: M F
authors.initials: MF
authors.lastname: Lyon
authors.forename: T R
authors.initials: TR
authors.lastname: King
authors.forename: Y
authors.initials: Y
authors.lastname: Gondo
authors.forename: J M
authors.initials: JM
authors.lastname: Gardner
authors.forename: Y
authors.initials: Y
authors.lastname: Nakatsu
authors.forename: E M
authors.initials: EM
authors.lastname: Eicher
authors.forename: M H
authors.initials: MH
authors.lastname: Brilliant
mesh_terms: D000483:Alleles; D000818:Animals; D015139:Blotting, Southern; D002872:Chromosome Deletion; D003433:Crosses, Genetic; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D005127:Eye Color / Q000235:genetics*; D005260:Female; D005808:Genes, Recessive; D005838:Genotype; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008817:Mice, Mutant Strains; D009154:Mutation
chemical_list: D004247:DNA