11;13 translocation in acute nonlymphocytic leukemia.
In this paper, we report on a 9-year-old girl with acute nonlymphocytic leukemia (FAB-M5) with a rare chromosome abnormality, t(11;23)(q21;p11). Peripheral blood showed Hb 7.5 g/dl, WBC 3,600 cells/microliters (10% blasts), and platelet count 110 x 10(3) cells/microliters. The bone marrow aspirates showed normal cellularity with 36.7% blasts. On morphological characteristics, micromegakaryocytes were observed, and on chromosome examination the karyotype was shown to be 46,XX,t(11;13)(q21;p11) in all metaphases.
Sugita
K
K
Second Department of Pediatrics, Dokkyo University School of Medicine, Tochigi, Japan.
Kurosawa
H
H
Sakakibara
H
H
Eguchi
M
M
Furukawa
T
T
Hanada
R
R
D001853:Bone Marrow / Q000378:metabolism / Q000648:ultrastructure; D002648:Child; D002880:Chromosomes, Human, Pair 11; D002882:Chromosomes, Human, Pair 13; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D014178:Translocation, Genetic