A neuropeptide Y (NPY)-related peptide is present in the river lamprey CNS.
Pancreatic polypeptide (PP)-like material from brain+spinal cord, and retina extracts of Lampetra fluviatilis was studied by HPLC and RIA. The brain+spinal cord extract showed a complex elution profile with multiple peaks of immunoreactivity. The retina extract showed a much simpler pattern with a single significant peak along with a trace of a second peak corresponding to the latest and penultimate peaks in the brain extract. Twenty-one out of 36 residues could be sequenced from the latest eluting peak in the brain extract. This sequence showed 81% identity with porcine neuropeptide (NPY) suggesting that both the brain/spinal cord and retina of the river lamprey contain a peptide homologous to NPY.
Rawitch
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AB
Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City 66103.
Pollock
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HG
Brodin
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L
D000595:Amino Acid Sequence; D000818:Animals; D001923:Brain Chemistry; D002851:Chromatography, High Pressure Liquid; D005768:Gastrointestinal Hormones / Q000032:analysis; D007798:Lampreys / Q000378:metabolism*; D008969:Molecular Sequence Data; D009478:Neuropeptide Y / Q000032:analysis*; D010191:Pancreatic Polypeptide / Q000032:analysis* / Q000737:chemistry; D019894:Peptide YY; D010455:Peptides / Q000032:analysis; D011863:Radioimmunoassay; D012160:Retina / Q000737:chemistry; D013116:Spinal Cord / Q000737:chemistry*
D005768:Gastrointestinal Hormones; D009478:Neuropeptide Y; D010455:Peptides; D019894:Peptide YY; D010191:Pancreatic Polypeptide