Serum lipoprotein profile in the Mediterranean variant of glucose-6-phosphate dehydrogenase deficiency.
Sardinian males with erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) deficiency have lower serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (ApoB), compared to normals. Since the enzyme deficiency is expressed also in nucleated cells, we studied cholesterol (C) and DNA synthesis and LDL-receptor expression in freshly isolated circulating mononuclear cells from normal and G-6-PD-deficient Sardinians. Synthesis of C (as 14C-acetate incorporation) and of DNA (as 3H-thymidine incorporation) was clearly reduced, both in basal state and after PHA stimulation, in G-6-PD-deficient cells compared to normal cells. On the other hand, no clear influence of G-6-PD deficiency on LDL-receptor expression could be demonstrated. The Mediterranean variant of G-6-PD deficiency is characterized, whatever the metabolic mechanism may be, by a serum lipoprotein pattern of reduced atherogenicity.
Muntoni
S
S
Centro Regionale per le Malattie Dismetaboliche e l'Arteriosclerosi, Ospedale G. Brotzu, Cagliari, Italy.
Batetta
B
B
Dessi
S
S
Muntoni
S
S
Pani
P
P
D000328:Adult; D001055:Apolipoproteins B / Q000097:blood* / Q000235:genetics; D008076:Cholesterol, HDL / Q000097:blood* / Q000235:genetics; D008078:Cholesterol, LDL / Q000097:blood* / Q000235:genetics; D003327:Coronary Disease / Q000209:etiology*; D004247:DNA / Q000096:biosynthesis; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood / Q000150:complications / Q000235:genetics / Q000378:metabolism*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007558:Italy; D008214:Lymphocytes / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011973:Receptors, LDL / Q000235:genetics / Q000378:metabolism*; D012307:Risk Factors
D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D011973:Receptors, LDL; D004247:DNA