title: Controlled-release tablet formulation of isoniazid.
abstract: Guar (GG) and Karaya gums (KG) alone and in combination with hydroxy-propylmethylcellulose (HPMC) were evaluated as release retarding materials to formulate a controlled-release tablet dosage form of isoniazid (1). In vitro release of 1 from tablets followed non-Fickian release profile with rapid initial release. Urinary excretion studies in normal subjects showed steady-state levels of 1 for 13 h. In vitro and in vivo data correlated (r = 0.9794). The studies suggested the potentiality of GG and KG as release retarding materials in formulating controlled-release tablet dosage forms of 1.
authors.affiliation: Department of Pharmaceutical Sciences, University of Saugor, Sagar, India.
authors.forename: N K
authors.initials: NK
authors.lastname: Jain
authors.forename: K
authors.initials: K
authors.lastname: Kulkarni
authors.forename: N
authors.initials: N
authors.lastname: Talwar
mesh_terms: D000328:Adult; D003692:Delayed-Action Preparations; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000652:urine; D012995:Solubility; D013607:Tablets
chemical_list: D003692:Delayed-Action Preparations; D013607:Tablets; D007538:Isoniazid