Peptide tyrosine phenylalanine: a novel neuropeptide F-related nonapeptide from the brain of the squid, Loligo vulgaris.
A novel nonapeptide, sequence YAIVARPRFamide, was isolated from brain extracts of the squid, L. vulgaris. Designated peptide tyrosine phenylalanine (PYF), the peptide shows marked homology with the C-terminal nonapeptides of pancreatic polypeptide and neuropeptide F (NPF) from a number of sources. If PYF is the C-terminal nonapeptide of squid NPF, then it may be derived by a novel processing mechanism involving specific cleavage between two TYR residues. PYF may be a highly truncated, receptor-active variant of NPF.
Smart
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Comparative Neuroendocrinology Research Group, School of Clinical Medicine, Queen's University of Belfast, N. Ireland, U.K.
Shaw
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Johnston
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C
Thim
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L
Halton
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Buchanan
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K
D000595:Amino Acid Sequence; D000818:Animals; D001923:Brain Chemistry; D002851:Chromatography, High Pressure Liquid; D049832:Decapodiformes / Q000737:chemistry*; D015801:Helminth Proteins / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009479:Neuropeptides / Q000737:chemistry* / Q000302:isolation & purification; D009842:Oligopeptides / Q000737:chemistry* / Q000302:isolation & purification; D011487:Protein Conformation; D012689:Sequence Homology, Nucleic Acid
D015801:Helminth Proteins; D009479:Neuropeptides; D009842:Oligopeptides; C076101:neuropeptide F; C076147:peptide tyrosine phenylalanine