[A case of acute cardiac insufficiency caused by 5-fluorouracil].
The authors report a case of acute cardiac failure linked to 5 fluoro-uracil. The toxicity seen most commonly involves ischemia. The pathophysiological mechanisms are discussed as well as the role played by pharmacokinetic characteristics in the occurrence of adverse reactions. 5 fluoro-uracil (5 FU) is a compound widely used in the treatment of ENT, breast and gastrointestinal carcinomas. The finding of dose-effect relationship may lead the clinician to use different modes of administration. Continuous administration at high dose 3 g/m2/day from D1 to D5) in combination or not with cisplatin, or continuously at low dose (300 mg/m2/day from D1 to D31) can reduce hematopoietic toxicity but, in contrast, increases gastrointestinal toxicity.
Fauchart
J P
JP
Service d'Hépatogastroentéroligie, Hôpital Manchester, Charleville-Mezières.
Favriel
J M
JM
Fallouh
R
R
Chapoutot
L
L
Bailly
L
L
D000230:Adenocarcinoma / Q000188:drug therapy*; D002303:Cardiac Output, Low / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D004077:Digoxin / Q000627:therapeutic use; D004232:Diuretics / Q000627:therapeutic use; D015150:Echocardiography, Doppler; D004562:Electrocardiography; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D006801:Humans; D008875:Middle Aged; D012811:Sigmoid Neoplasms / Q000188:drug therapy*
D004232:Diuretics; D004077:Digoxin; D005472:Fluorouracil
Un cas d'insuffisance cardiaque aiguë due au 5 fluoro-uracile.