Hereditary aspects of colorectal adenomas.
BACKGROUND
Inheritance is important to the development of colonic adenomatous polyps and colon cancer. Current knowledge of inherited susceptibility to colonic neoplasms suggests that colon cancer screening strategies should consider familial and genetic risk.


METHODS
This report reviews the literature pertinent to adenomatous polyp and colon cancer inheritance and suggests polyp-cancer screening procedures based on inherited or familial risk.


RESULTS
Colorectal adenomas and cancer occur in several rare inherited syndromes and more commonly as sporadic cases. Intensive screening protocols have been suggested for the inherited syndromes because of the high associated cancer risk. Recent evidence suggests that inherited susceptibility also may be important in a large fraction of the so-called sporadic cases. Preliminary screening guidelines are suggested for this category based on the number of first-degree relatives affected with colon cancer.


CONCLUSIONS
Inherited susceptibility appears to be more important to the pathogenesis of colorectal adenomas and cancer than previously recognized. Screening strategies which consider inherited risk may increase the effectiveness of cancer detection and prevention.
Burt
R W
RW
Department of Medicine, University of Utah College of Medicine, Salt Lake City.
Bishop
D T
DT
Cannon-Albright
L
L
Samowitz
W S
WS
Lee
R L
RL
DiSario
J A
JA
Skolnick
M H
MH
D000236:Adenoma / Q000235:genetics*; D000328:Adult; D002648:Child; D003111:Colonic Polyps / Q000235:genetics; D015179:Colorectal Neoplasms / Q000235:genetics*; D005192:Family Health; D006801:Humans