title: [The Philadelphia chromosome 30 years later].
abstract: We review the changing concepts regarding the nature of the Ph chromosome during the last thirty years. The role of molecular biology techniques in its identification are discussed as well as its present status in the diagnosis, prognosis and management of chronic myelogenous leukemia and acute lymphoblastic leukemia.
authors.affiliation: Departamento de Genética, Instituto Nacional de la Nutrición Salvador Zubirán, D.F., México.
authors.forename: R
authors.initials: R
authors.lastname: Lisker
mesh_terms: D002869:Chromosome Aberrations; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D016313:Genes, abl; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Q000235:genetics; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics; D011379:Prognosis
chemical_list: D016044:Fusion Proteins, bcr-abl
vernacular_title: El cromosoma Filadelfia 30 años después.