Differential effects of diazepam and lorazepam on repetition priming in healthy volunteers.
The effects of two benzodiazepines, diazepam (15 or 20 mg orally) and lorazepam (1.75 or 2.5 mg orally), and a placebo on explicit memory, lexical priming and perceptual priming were assessed using a free-recall, a word-completion and a picture-completion test. The picture-completion test included two different study conditions intended to manipulate the magnitude of the priming effect. Sixty healthy volunteers took part in this double-blind study. Free-recall performances were altered by both drugs. Lorazepam impaired word-completion and picture-completion performance, whereas diazepam only exhibited a deleterious effect on the more sensitive of the two measures of the picture-completion test. These results indicate that the two benzodiazepines have differential amnestic effects. It is suggested that these differential effects could be accounted for by a different cortical distribution of the two benzodiazepines.
Sellal
F
F
Clinique Neurologique, Hôpitaux Universitaires, Strasbourg, France.
Danion
J M
JM
Kauffmann-Muller
F
F
Grangé
D
D
Imbs
J L
JL
Van der Linden
M
M
Singer
L
L
D000328:Adult; D003071:Cognition / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D008140:Lorazepam / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects*
D006993:Hypnotics and Sedatives; D008140:Lorazepam; D003975:Diazepam