Antigenic modulation of metastatic breast and ovary carcinoma cells by intracavitary injection of IFN-alpha.
Antigenic modulation of major histocompatibility and tumour associated antigens was observed in neoplastic cells obtained from patients with pleural and abdominal effusions of breast and ovary carcinomas following a single intracavitary dose of 18 x 10(6) U recombinant IFN-alpha. This regimen resulted in antigenic modulation in seven out of 11 tested cases, suggesting a potential, although limited, responsiveness of at least a fraction of breast and ovary carcinoma cells to in situ biomodification with IFN-alpha.
Giacomini
P
P
Department of Pathology, Regina Elena Institute, Rome, Italy.
Mottolese
M
M
Fraioli
R
R
Benevolo
M
M
Venturo
I
I
Natali
P G
PG
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis*; D001201:Ascites / Q000276:immunology; D001943:Breast Neoplasms / Q000276:immunology* / Q000628:therapy; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006681:HLA-D Antigens / Q000032:analysis*; D015395:Histocompatibility Antigens Class I / Q000032:analysis*; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D010051:Ovarian Neoplasms / Q000276:immunology* / Q000628:therapy; D016066:Pleural Effusion, Malignant / Q000276:immunology; D011994:Recombinant Proteins
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D006681:HLA-D Antigens; D015395:Histocompatibility Antigens Class I; D007370:Interferon Type I; D011994:Recombinant Proteins