title: Metabolism of glucurolactone to glucarate in Parkinson's disease.
abstract: The metabolism of oral glucurolactone to serum D-glucarate by the hepatic cytochrome P450 enzyme system was no different in 20 untreated Parkinson's disease (PD) patients as compared with 20 age- and sex-matched controls. There was no evidence for a deficit in hepatic enzymes in PD.
authors.affiliation: Department of Neurology, University of Kansas Medical Center, Kansas City 66160-7314.
authors.forename: W C
authors.initials: WC
authors.lastname: Koller
authors.forename: S D
authors.initials: SD
authors.lastname: Rope
authors.forename: S J
authors.initials: SJ
authors.lastname: Huber
authors.forename: D C
authors.initials: DC
authors.lastname: Blumenthal
authors.forename: H J
authors.initials: HJ
authors.lastname: Blumenthal
mesh_terms: D000284:Administration, Oral; D000368:Aged; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005260:Female; D005937:Glucaric Acid / Q000097:blood*; D005965:Glucuronates / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000201:enzymology; D008297:Male; D010300:Parkinson Disease / Q000378:metabolism*
chemical_list: D005965:Glucuronates; C004940:glucuronolactone; D003577:Cytochrome P-450 Enzyme System; D005937:Glucaric Acid