Hypersensitivity reactions to cisplatin and carboplatin--a report on six cases.
Anaphylactic reactions to platinum compounds are well recognised, but uncommon. These vary from true type I reactions to direct histamine release due to nonimmunological mechanisms. We present 6 cases to illustrate this--5 due to cisplatin and a report of this occurring with carboplatin--with a near fatal outcome in 3 of the cases.
Saunders
M P
MP
Department of Medicine, Royal Marsden Hospital, London, U.K.
Denton
C P
CP
O'Brien
M E
ME
Blake
P
P
Gore
M
M
Wiltshaw
E
E
D000328:Adult; D000368:Aged; D000707:Anaphylaxis / Q000139:chemically induced*; D016190:Carboplatin / Q000009:adverse effects*; D002945:Cisplatin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D016190:Carboplatin; D002945:Cisplatin