title: Partial molar volumes of the amino acid side-chains of proteins in aqueous solution: some comments on their estimation using partial molar volumes of amino acids and small peptides.
abstract: The partial molar volumes of some amino acid side-chains were determined in two recent studies [Makhatadze, G.I., et al. (1990) Biopolymers 30, 1001, and Reading, J.F. & Hedwig, G.R. (1990) J. Chem. Soc. Faraday Trans. 86, 3117] using partial molar volume data, V02, in aqueous solution at 25 degrees C for some peptides of sequence Gly-X-Gly, where X is an amino acid. These side-chain partial molar volumes are critically compared with those obtained using V02 data for amino acids. It is concluded that side-chain partial molar volumes calculated using V02 data for the tripeptides are better estimates of side-chain partial molar volumes in proteins than are those determined using V02 data for amino acids.
authors.affiliation: Department of Chemistry and Biochemistry, Massey University, Palmerston North, New Zealand.
authors.forename: G R
authors.initials: GR
authors.lastname: Hedwig
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids; D004151:Dipeptides / Q000737:chemistry*; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry*; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000596:Amino Acids; D004151:Dipeptides; D009842:Oligopeptides; D011506:Proteins