title: [Current pathogenetic principles in peptic ulcer].
abstract: New concepts in the pathophysiology of peptic ulcers must acknowledge 1. the close association of ulcers and Helicobacter pylori infection, 2. the protective role of endogenous prostaglandins, 3. the scarcity of new data on the importance of acidity (though presence of gastric acid remains indispensible for ulcer development). The different pathophysiologically relevant factors closely interact with each other. However, many not of actual concepts are still experimental and--apart from Helicobacter pylori--have not yet led to new therapeutical approaches.
authors.affiliation: Philipps-Universität Marburg, Zentrum für Innere Medizin.
authors.forename: H
authors.initials: H
authors.lastname: Koop
mesh_terms: D005744:Gastric Acid / Q000378:metabolism; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D010437:Peptic Ulcer / Q000382:microbiology / Q000503:physiopathology*; D011453:Prostaglandins / Q000378:metabolism
chemical_list: D011453:Prostaglandins
vernacular_title: Neue pathogenetische Prinzipien beim peptischen Ulkus.