Effects of sevoflurane and isoflurane on hepatic circulation in the chronically instrumented dog.
To compare the effects of sevoflurane and isoflurane on hepatic circulation, eighteen dogs were chronically instrumented for measurements of mean aortic blood pressure and cardiac output and for simultaneous measurements of hepatic and portal blood flows. Each animal was studied while awake and during 1.2 and 2 MAC of either isoflurane or sevoflurane. Both anesthetics induced tachycardia and a dose-dependent decrease in mean aortic blood pressure (isoflurane -27% and -39%; sevoflurane -22% and -37%). Cardiac output decreased only at the highest concentration (isoflurane -10%; sevoflurane -21%). During sevoflurane, portal blood flow decreased at both 1.2 and 2 MAC (-14 and -33%, respectively), whereas an increase in hepatic arterial blood flow was recorded at 2 MAC (+33%). During isoflurane, the only significant change was a decrease in portal blood flow (-16%) at 1.2 MAC. Neither anesthetic significantly changed renal blood flow. Therefore, both anesthetics led to similar systemic and hepatic vasodilation.
Bernard
J M
JM
Department of Anesthesiology, Baylor College of Medicine, Houston, Texas.
Doursout
M F
MF
Wouters
P
P
Hartley
C J
CJ
Merin
R G
RG
Chelly
J E
JE
D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D000077335:Desflurane; D004285:Dogs; D004737:Enflurane / Q000494:pharmacology; D004987:Ethers / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D007530:Isoflurane / Q000031:analogs & derivatives / Q000494:pharmacology*; D008102:Liver Circulation / Q000187:drug effects*; D008738:Methyl Ethers; D009609:Nitrous Oxide; D000077149:Sevoflurane
D000777:Anesthetics; D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane; D004737:Enflurane; D000077335:Desflurane; D007530:Isoflurane; D009609:Nitrous Oxide