Efficacy of dapsone with pyrimethamine (Maloprim) for malaria prophylaxis in Maputo, Mozambique.
In a randomized controlled study of malaria prophylaxis, dapsone-pyrimethamine at a weekly dosage of dapsone 50-100 mg with pyrimethamine 6.25-12.5 mg or placebo was administered to 166 school children for 17 weeks. Fortnightly parasitological controls revealed 28 infections in the placebo group and none in the dapsone-pyrimethamine group. It is concluded that weekly dapsone-pyrimethamine is effective for the prophylaxis of falciparum malaria in Mozambique.
Pividal
J
J
Sector de Malaria, Instituto Nacional de Saude, Maputo, Mozambique.
Viktinski
V
V
Streat
E
E
Schapira
A
A
D002648:Child; D003622:Dapsone / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D016778:Malaria, Falciparum / Q000469:parasitology / Q000517:prevention & control*; D009073:Mozambique; D011739:Pyrimethamine / Q000008:administration & dosage / Q000627:therapeutic use*
D003622:Dapsone; D011739:Pyrimethamine