Effect of aging on contractile response to KCl, norepinephrine and 5-hydroxytryptamine in isolated human basilar artery.
1. We investigated the effect of aging on contractile response in human basilar artery. 2. The maximal contraction caused by KCl, norepinephrine and 5-hydroxytryptamine decreased with age. 3. ED50 value for norepinephrine or 5-hydroxytryptamine did not correlate with age. 4. These results suggest that the decrease in contractile response is due to nonspecific changes in the medial structure of the artery.
Hatake
K
K
Department of Legal Medicine, Hyogo College of Medicine, Japan.
Wakabayashi
I
I
Kakishita
E
E
Hishida
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001488:Basilar Artery / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology*
D012701:Serotonin; D011189:Potassium Chloride; D009638:Norepinephrine