title: A neuropeptide Y (NPY)-related peptide is present in the river lamprey CNS.
abstract: Pancreatic polypeptide (PP)-like material from brain+spinal cord, and retina extracts of Lampetra fluviatilis was studied by HPLC and RIA. The brain+spinal cord extract showed a complex elution profile with multiple peaks of immunoreactivity. The retina extract showed a much simpler pattern with a single significant peak along with a trace of a second peak corresponding to the latest and penultimate peaks in the brain extract. Twenty-one out of 36 residues could be sequenced from the latest eluting peak in the brain extract. This sequence showed 81% identity with porcine neuropeptide (NPY) suggesting that both the brain/spinal cord and retina of the river lamprey contain a peptide homologous to NPY.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City 66103.
authors.forename: A B
authors.initials: AB
authors.lastname: Rawitch
authors.forename: H G
authors.initials: HG
authors.lastname: Pollock
authors.forename: L
authors.initials: L
authors.lastname: Brodin
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001923:Brain Chemistry; D002851:Chromatography, High Pressure Liquid; D005768:Gastrointestinal Hormones / Q000032:analysis; D007798:Lampreys / Q000378:metabolism*; D008969:Molecular Sequence Data; D009478:Neuropeptide Y / Q000032:analysis*; D010191:Pancreatic Polypeptide / Q000032:analysis* / Q000737:chemistry; D019894:Peptide YY; D010455:Peptides / Q000032:analysis; D011863:Radioimmunoassay; D012160:Retina / Q000737:chemistry; D013116:Spinal Cord / Q000737:chemistry*
chemical_list: D005768:Gastrointestinal Hormones; D009478:Neuropeptide Y; D010455:Peptides; D019894:Peptide YY; D010191:Pancreatic Polypeptide