title: Hereditary nonspherocytic hemolytic anemia due to pyruvate kinase deficiency: a prevalence study in Quebec (Canada).
abstract: Fifty-eight cases of hereditary nonspherocytic hemolytic anemia due to pyruvate kinase deficiency were collected from both laboratories that have performed the assay since 1972 and from attending physicians in the province of Quebec. Using the postal addresses of the probands, a prevalence map was constructed according to the administrative regions of the province of Quebec. The prevalence was found to be higher in eastern Quebec (1/81,838) than in western Quebec (1/139,086). Fifty probands were of French Canadian origin whereas the remaining 6 were recent immigrants.
authors.affiliation: Département de Biochimie, Faculté de Médecine, Université de Sherbrooke, Qué., Canada.
authors.forename: E
authors.initials: E
authors.lastname: de Medicis
authors.forename: P
authors.initials: P
authors.lastname: Ross
authors.forename: R
authors.initials: R
authors.lastname: Friedman
authors.forename: H
authors.initials: H
authors.lastname: Hume
authors.forename: D
authors.initials: D
authors.lastname: Marceau
authors.forename: M
authors.initials: M
authors.lastname: Milot
authors.forename: J
authors.initials: J
authors.lastname: Lyonnais
authors.forename: M
authors.initials: M
authors.lastname: De Braekeleer
mesh_terms: D000746:Anemia, Hemolytic, Congenital Nonspherocytic / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D015995:Prevalence; D011770:Pyruvate Kinase / Q000172:deficiency*; D011792:Quebec / Q000453:epidemiology
chemical_list: D011770:Pyruvate Kinase