title: Surgical treatment of invasive carcinoma of the vulva. A reappraisal.
abstract: The Authors studied three groups of patients affected by invasive vulvar carcinoma. The first group (19 cases), treated by radical vulvectomy and bilateral inguinal lymphadenectomy, had a survival rate at 5 years of 89% in Stage I and 56% in Stage II. The second group (9 cases) which presented poor general health conditions, had a survival rate at 4 years of 33% and 14% in Stage I and in Stage II, respectively. The third group of patients (7 cases), who refused any type of treatment, died within 12 months. Nodal involvement influenced survival rate. In fact, regardless of the stage, a survival rate at 5 years of 92% and 26% was seen in patients with negative nodes and positive nodes, respectively. In conclusion, the study confirms that radical surgery is the therapy of choice in advanced carcinoma of the vulva. However, early diagnosis remains the most important agent in reducing the extension of the surgical treatment.
authors.affiliation: Institute of Obstetrics & Gynecology and Pathological Anatomy, University of Ferrara, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Levato
authors.forename: A
authors.initials: A
authors.lastname: Bianchi
authors.forename: B
authors.initials: B
authors.lastname: Lenzi
authors.forename: F
authors.initials: F
authors.lastname: Pansini
authors.forename: F
authors.initials: F
authors.lastname: Randazzo
authors.forename: S
authors.initials: S
authors.lastname: Ferretti
authors.forename: E
authors.initials: E
authors.lastname: Grandi
authors.forename: G
authors.initials: G
authors.lastname: Mollica
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000556:secondary / Q000601:surgery*; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011183:Postoperative Complications; D016019:Survival Analysis; D014846:Vulvar Neoplasms / Q000473:pathology / Q000601:surgery*