Protection from chemotherapy-induced alopecia by 1,25-dihydroxyvitamin D3.
We have previously reported that several biological agents, when given simultaneously with cytosine arabinoside or cytoxan, will protect from cytosine arabinoside-induced but not from cytoxan-induced alopecia. In the present study we used the secosteroid 1,25-dihydroxyvitamin D3 in a different timing schedule to protect from chemotherapy-induced alopecia. In three separate experiments, 0.2 microgram of topical, 1,25-dihydroxyvitamin D3 protected rats from alopecia induced by etoposide, cytoxan, and an Adriamycin-cytoxan combination. In another experiment, 0.1 microgram protected rats from etoposide-induced alopecia at the site of application. 1,25-Dihydroxyvitamin D3 may offer a new and exciting approach to the prevention of chemotherapy-induced alopecia.
Jimenez
J J
JJ
Department of Medicine, University of Miami School of Medicine, Florida.
Yunis
A A
AA
D000477:Alkylating Agents / Q000494:pharmacology*; D000505:Alopecia / Q000139:chemically induced / Q000517:prevention & control*; D000818:Animals; D000970:Antineoplastic Agents / Q000037:antagonists & inhibitors*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000037:antagonists & inhibitors; D002117:Calcitriol / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors; D004317:Doxorubicin / Q000037:antagonists & inhibitors; D005047:Etoposide / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains
D000477:Alkylating Agents; D000970:Antineoplastic Agents; D005047:Etoposide; D004317:Doxorubicin; D003520:Cyclophosphamide; D002117:Calcitriol