Bentiromide test using liquid-chromatographic measurement of p-aminobenzoic acid and its metabolites for diagnosing pancreatic insufficiency in childhood.
We assessed the diagnostic capability of the bentiromide test using a high-pressure liquid-chromatography method to analyze p-aminobenzoic acid and its metabolites in plasma as an indirect measure of exocrine pancreatic function. Mean total amine concentration in pancreatic-insufficient subjects was significantly lower than in control subjects. There were 3 of 15 false-negative results and no false-positive results. We conclude that this chromatographic method is an effective means of analyzing p-aminobenzoic acid and its metabolites after ingestion of bentiromide.
Durie
P R
PR
Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
Yung-Jato
L Y
LY
Soldin
S J
SJ
Verjee
Z
Z
Ellis
L
L
D010129:4-Aminobenzoic Acid / Q000097:blood* / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003550:Cystic Fibrosis / Q000097:blood / Q000150:complications; D010188:Exocrine Pancreatic Insufficiency / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D062366:para-Aminobenzoates
D062366:para-Aminobenzoates; C006717:bentiromide; D010129:4-Aminobenzoic Acid