title: Ventricular fibrillation during acute rejection after heart transplantation.
abstract: The case of a 46-year-old patient who underwent orthotopic heart transplantation for treatment of end-stage heart failure as a result of ischemic heart disease is reported. Four months after transplantation a grade II rejection episode was complicated by ventricular fibrillation. Lidocaine and procainamide intravenously did not effectively prevent recurrence. An increase of antirejection therapy in combination with flecainide acetate effectively prevented further episodes of ventricular fibrillation. This case demonstrates that recurrent ventricular fibrillation can be a complication of acute rejection.
authors.affiliation: Transplantation Unit, Heart Lung Institute, University Hospital Utrecht, The Netherlands.
authors.forename: N
authors.initials: N
authors.lastname: de Jonge
authors.forename: G
authors.initials: G
authors.lastname: Jambroes
authors.forename: J R
authors.initials: JR
authors.lastname: Lahpor
authors.forename: S R
authors.initials: SR
authors.lastname: Woolley
mesh_terms: D004562:Electrocardiography; D005424:Flecainide / Q000627:therapeutic use; D006084:Graft Rejection; D016027:Heart Transplantation / Q000276:immunology*; D006801:Humans; D007165:Immunosuppression Therapy; D008297:Male; D008875:Middle Aged; D011342:Procainamide / Q000627:therapeutic use; D014693:Ventricular Fibrillation / Q000209:etiology* / Q000517:prevention & control
chemical_list: D005424:Flecainide; D011342:Procainamide