Augmentation of mitogen-induced interleukin 2 production by oral administration of polysaccharide SPR-901.
The effects of oral administration of antitumor polysaccharide SPR-901 (RBS), an alpha-1,3 branched alpha-1,6 glucan, on concanavalin A (Con A)-induced interleukin 2 (IL-2) production of splenocytes were studied. The augmentation effect on Con A-induced IL-2 production was evident when more than 30 mg/kg of SPR-901 was administered orally to mice. On the other hand, oral administration of B512 dextran, an analogous alpha-1,6 glucan, did not show any augmentation effects on IL-2 production. The augmentation effect of SPR-901 on IL-2 production seemed to be mediated mainly by macrophages stimulated with SPR-901.
Tanaka
M
M
Pharmaceutical Research Laboratories, Sapporo Breweries Ltd., Yaizu, Japan.
Miyazaki
H
H
Takeda
Y
Y
Takeo
S
S
Yoshikai
Y
Y
Nomoto
K
K
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000284:Administration, Oral; D000818:Animals; D003208:Concanavalin A / Q000008:administration & dosage; D005260:Female; D005936:Glucans / Q000008:administration & dosage*; D007376:Interleukin-2 / Q000096:biosynthesis*; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000276:Adjuvants, Immunologic; D005936:Glucans; D007376:Interleukin-2; D003208:Concanavalin A