title: Anemia and neutropenia in a case of copper deficiency: role of copper in normal hematopoiesis.
abstract: We present a patient who developed severe anemia and neutropenia after receiving parenteral nutrition for 2.5 years. The serum levels of copper and ceruloplasmin were low, and the bone marrow showed the presence of ringed sideroblasts and vacuolated immature cells. The administration of copper chloride by bolus injection led to a rapid improvement in anemia and neutropenia. The number of progenitor cells (colony-forming unit-granulocyte-macrophage and erythrocyte) present before the copper supplementation was well preserved. It is therefore suggested that copper enzymes play an important role in the maturation of hematopoietic cells.
authors.affiliation: Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Hirase
authors.forename: Y
authors.initials: Y
authors.lastname: Abe
authors.forename: S
authors.initials: S
authors.lastname: Sadamura
authors.forename: Y
authors.initials: Y
authors.lastname: Yufu
authors.forename: K
authors.initials: K
authors.lastname: Muta
authors.forename: T
authors.initials: T
authors.lastname: Umemura
authors.forename: J
authors.initials: J
authors.lastname: Nishimura
authors.forename: H
authors.initials: H
authors.lastname: Nawata
authors.forename: H
authors.initials: H
authors.lastname: Ideguchi
mesh_terms: D000368:Aged; D000740:Anemia / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D001856:Bone Marrow Examination; D003300:Copper / Q000008:administration & dosage / Q000097:blood / Q000172:deficiency*; D005260:Female; D006410:Hematopoiesis / Q000502:physiology*; D006801:Humans; D009503:Neutropenia / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D010289:Parenteral Nutrition, Total; D011178:Postgastrectomy Syndromes / Q000628:therapy; D013997:Time Factors
chemical_list: D003300:Copper; C028419:cuprous chloride