title: Fumonisin toxicity in broiler chicks.
abstract: The effects of dietary fumonisin B1 were evaluated in young broiler chicks. The experimental design consisted of 5 treatments each with 9 randomly allotted male broiler chicks. Day-old chicks were fed diets containing 0 (feed control), 100, 200, 300, or 400 mg fumonisin B1/kg feed for 21 days. Response variables measured were chick performance, organ weights, serum biochemistry, and histologic parameters. Body weights and average daily gain dramatically decreased with increasing dietary fumonisin B1, and liver, proventriculus, and gizzard weights increased. Diarrhea, thymic cortical atrophy, multifocal hepatic necrosis, biliary hyperplasia, and rickets were present in chicks fed diets containing fumonisin B1. Serum calcium, cholesterol, and aspartate aminotransferase levels all increased at higher fumonisin dietary levels. Results indicate that fumonisin, from Fusarium moniliforme culture material, is toxic in young chicks.
authors.affiliation: Animal Sciences Department, University of Missouri, Columbia 65211.
authors.forename: D R
authors.initials: DR
authors.lastname: Ledoux
authors.forename: T P
authors.initials: TP
authors.lastname: Brown
authors.forename: T S
authors.initials: TS
authors.lastname: Weibking
authors.forename: G E
authors.initials: GE
authors.lastname: Rottinghaus
mesh_terms: D000821:Animal Feed / Q000633:toxicity*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D002118:Calcium / Q000097:blood; D002645:Chickens; D002784:Cholesterol / Q000097:blood; D005516:Food Microbiology; D005517:Foodborne Diseases / Q000209:etiology / Q000662:veterinary; D037341:Fumonisins; D005895:Gizzard, Avian / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D009183:Mycotoxins / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D011201:Poultry Diseases / Q000139:chemically induced*; D011531:Proventriculus / Q000187:drug effects; D011897:Random Allocation; D012709:Serum Albumin / Q000032:analysis
chemical_list: D001786:Blood Glucose; D037341:Fumonisins; D009183:Mycotoxins; D012709:Serum Albumin; C056933:fumonisin B1; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D002118:Calcium