title: [The LPS-protein complex from the outer membrane of Francisella tularensis].
abstract: LPS-protein complex containing proteins of 15 kD, 17 kD and 19 kD was isolated from F. tularensis outer membrane by solving with sodium deoxycholate with the subsequent gel filtration on Sephacryl S-200. Protein of 17 kD constituted the main protein component of the complex. The LPS-protein ratio of this complex was 1:1. Proteins contained in LPS-protein complex have mainly the alpha-spiral structure. In the absence of detergent these proteins and LPS formed micelles with molecular weight exceeding 10(7) D. LPS-protein complex was shown to have a protective effect in mice infected with F. tularensis virulent strain 503.
authors.forename: V S
authors.initials: VS
authors.lastname: Khlebnikov
authors.forename: D P
authors.initials: DP
authors.lastname: Kulevatskiĭ
authors.forename: I R
authors.initials: IR
authors.lastname: Golovlev
authors.forename: S F
authors.initials: SF
authors.lastname: Averin
authors.forename: V E
authors.initials: VE
authors.lastname: Zhemchugov
authors.forename: A M
authors.initials: AM
authors.lastname: Chugunov
authors.forename: S S
authors.initials: SS
authors.lastname: Afanas'ev
mesh_terms: D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism*; D002850:Chromatography, Gel; D002942:Circular Dichroism; D004591:Electrophoresis, Polyacrylamide Gel; D005604:Francisella tularensis / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000378:metabolism*; D051379:Mice; D008823:Micelles; D013055:Spectrophotometry, Infrared
chemical_list: D001425:Bacterial Outer Membrane Proteins; D008070:Lipopolysaccharides; D008823:Micelles
vernacular_title: Issledovanie LPS-belkovogo kompleksa iz vneshneĭ membrany Francisella tularensis.