title: Acute renal failure following binge drinking and nonsteroidal antiinflammatory drugs.
abstract: Two college students who developed reversible acute deterioration in renal function following binge drinking of beer and the use of nonsteroidal antiinflammatory drugs (NSAIDs) are reported. Both patients presented with back and flank pain with muscle tenderness, but showed no evidence of overt rhabdomyolysis. The first case had marked renal failure, with a peak serum creatinine reaching 575 mumol/L (6.5 mg/dL), and acute tubular necrosis was documented by renal biopsy. The second case had only modest elevation in serum creatinine, and renal function rapidly improved on rehydration. The contribution of the potential muscle damage associated with alcohol ingestion to the changes in renal function in these two cases is not clear. However, the major mechanism for the acute renal failure was thought to be related to inhibition of renal prostaglandin synthesis in the face of compromised renal hemodynamics secondary to alcohol-induced volume depletion.
authors.affiliation: Department of Medicine, University of Wisconsin Center for Health Sciences, Madison.
authors.forename: S F
authors.initials: SF
authors.lastname: Wen
authors.forename: R
authors.initials: R
authors.lastname: Parthasarathy
authors.forename: O
authors.initials: O
authors.lastname: Iliopoulos
authors.forename: T D
authors.initials: TD
authors.lastname: Oberley
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000473:pathology; D000328:Adult; D000435:Alcoholic Intoxication / Q000150:complications*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects; D001515:Beer / Q000009:adverse effects*; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects; D007668:Kidney / Q000473:pathology; D007683:Kidney Tubular Necrosis, Acute / Q000209:etiology / Q000473:pathology; D008297:Male
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin; D007052:Ibuprofen