title: Ammonia: a possible promotor in Helicobacter pylori-related gastric carcinogenesis.
abstract: Helicobacter pylori (HP) has been shown to possibly be a pathogen of gastric carcinoma. HP has urease activity and produces ammonia in the stomach. In this study, the role of ammonia on gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were investigated in rats. After 24 weeks pretreatment with MNNG (83 mg/l), 0.01% ammonia or tap water as a drinking water was administered for 24 weeks. The ammonia-treated rats showed a significantly higher incidence of gastric cancer (percent of animals with tumors and number of tumors per rat). Ammonia would thus appear to have an important role in HP-related human gastric carcinogenesis.
authors.affiliation: Department of Medicine, Osaka University Medical School, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tsujii
authors.forename: S
authors.initials: S
authors.lastname: Kawano
authors.forename: S
authors.initials: S
authors.lastname: Tsuji
authors.forename: K
authors.initials: K
authors.lastname: Nagano
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: N
authors.initials: N
authors.lastname: Hayashi
authors.forename: H
authors.initials: H
authors.lastname: Fusamoto
authors.forename: T
authors.initials: T
authors.lastname: Kamada
authors.forename: K
authors.initials: K
authors.lastname: Tamura
mesh_terms: D000230:Adenocarcinoma / Q000139:chemically induced*; D000284:Administration, Oral; D000641:Ammonia / Q000633:toxicity*; D000818:Animals; D002471:Cell Transformation, Neoplastic; D016480:Helicobacter pylori / Q000472:pathogenicity; D008297:Male; D008769:Methylnitronitrosoguanidine; D051381:Rats; D011919:Rats, Inbred Strains; D013274:Stomach Neoplasms / Q000139:chemically induced*
chemical_list: D008769:Methylnitronitrosoguanidine; D000641:Ammonia