Controlled cisplatin delivery system using poly(D,L-lactic acid).
Cisplatin (CDDP)-containing poly(D,L-lactic acid) microspheres (CDDP-MS) and beads (CDDP-B) with an average molecular weight of the oligomer of 1.2 x 10(4) and 4% CDDP loading were prepared. In Tris buffer, 95% of CDDP disappeared from CDDP-MS within 3 d. In vitro and in vivo, CDDP-B released CDDP for 30-57 d, and for 21-42 d, respectively. The other CDDP-B with an average oligomer molecular weight of 9.6 x 10(3) with 5% lactic acid monomers, that contained 4% CDDP, showed a two-phase CDDP release pattern and CDDP disappeared within 41 d in vitro, and within 21 d in vivo. Histologically, tissue necrosis surrounding the CDDP-B was not severe.
Ike
O
O
Research Center for Biomedical Engineering, Kyoto University, Japan.
Shimizu
Y
Y
Wada
R
R
Hyon
S H
SH
Ikada
Y
Y
D000818:Animals; D002626:Chemistry, Pharmaceutical; D002945:Cisplatin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations; D007773:Lactates / Q000008:administration & dosage* / Q000493:pharmacokinetics; D019344:Lactic Acid; D008297:Male; D008863:Microspheres; D009132:Muscles / Q000187:drug effects; D011091:Polyesters; D011108:Polymers / Q000008:administration & dosage* / Q000493:pharmacokinetics; D011817:Rabbits; D014325:Tromethamine
D003692:Delayed-Action Preparations; D007773:Lactates; D011091:Polyesters; D011108:Polymers; D014325:Tromethamine; D019344:Lactic Acid; C033616:poly(lactide); D002945:Cisplatin