Propofol anaesthesia in malignant hyperpyrexia susceptible swine.
1. Malignant hyperpyrexia (MH) is an inherited muscle abnormality that presents clinically as a syndrome of life-threatening complications during general anaesthesia. 2. Propofol is a new sedative hypnotic used for the induction and maintenance of anaesthesia. 3. Propofol did not induce MH in five susceptible pigs. Propofol did not induce contracture in isolated MH susceptible muscle but did modify halothane, caffeine and KCl contractures.
Foster
P S
PS
Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT.
Hopkinson
K C
KC
Denborough
M A
MA
D000758:Anesthesia / Q000009:adverse effects*; D000818:Animals; D002110:Caffeine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D005260:Female; D006221:Halothane / Q000037:antagonists & inhibitors / Q000494:pharmacology; D007275:Injections, Intravenous; D008297:Male; D008305:Malignant Hyperthermia / Q000209:etiology* / Q000517:prevention & control; D009119:Muscle Contraction / Q000187:drug effects; D011189:Potassium Chloride / Q000037:antagonists & inhibitors / Q000494:pharmacology; D015742:Propofol / Q000494:pharmacology; D013552:Swine
D002110:Caffeine; D011189:Potassium Chloride; D006221:Halothane; D015742:Propofol