title: [Obstetrical management of dysfibrinogenemia with increased thrombophilia].
abstract: Dysfibrinogenaemias are characterised by qualitatively abnormal fibrinogen, causing functional defects. In pregnant women, the incidence of recurrent abortions and placental abruption as well as haemostatic complications is high. In this case report, we report on a 22 year old woman with dysfibrinogenaemia complicated by thrombotic episodes. After two stillbirths under dramatic circumstances (placental abruption, eclampsia) and after an early abortion (7th gestational week), the patient was treated by subcutaneously administered heparin. Pregnancy ended successfully by delivery in the 39th gestational week.
authors.affiliation: Geburtshilflich-gynäkologische Abteilung, Hanusch-Krankenhaus Wien.
authors.forename: M
authors.initials: M
authors.lastname: Klein
authors.forename: A
authors.initials: A
authors.lastname: Rosen
authors.forename: P
authors.initials: P
authors.lastname: Kyrle
authors.forename: A
authors.initials: A
authors.lastname: Beck
mesh_terms: D000328:Adult; D000347:Afibrinogenemia / Q000097:blood / Q000188:drug therapy*; D001780:Blood Coagulation Tests; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005340:Fibrinogen / Q000378:metabolism; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000188:drug therapy*; D013924:Thrombophlebitis / Q000097:blood / Q000188:drug therapy*
chemical_list: D005340:Fibrinogen; D006493:Heparin
vernacular_title: Geburtshilfliches Management bei Dysfibrinogenämie mit erhöhter Thromboseneigung.