Comparison of the protective effect of Withaferin-'A' and hydrocortisone against CCL4 induced hepatotoxicity in rats.
Protective effect of Withaferin-'A' against CCl4 induced hepatotoxicity has been assessed and the compound at 10 mg/kg dose was found to possess significant protective effect. A comparison of this protective effect with that of hydrocortisone showed it to be as effective as hydrocortisone dose per dose.
Sudhir
S
S
Department of Pharmacology, Medical College, Rohtak.
Budhiraja
R D
RD
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury; D004347:Drug Interactions; D004875:Ergosterol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D006854:Hydrocortisone / Q000008:administration & dosage / Q000494:pharmacology; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008107:Liver Diseases / Q000517:prevention & control; D008297:Male; D051381:Rats; D054358:Withanolides
D001798:Blood Proteins; D054358:Withanolides; D002251:Carbon Tetrachloride; D000469:Alkaline Phosphatase; C009684:withaferin A; D006854:Hydrocortisone; D004875:Ergosterol