Modulation of calf immune responses by Ostertagia ostertagi: the effect of diet during trickle infection.
The effects of Ostertagia ostertagi infection and diet on antibody responses to O. ostertagi third stage larval (L3) antigen and to an unrelated antigen, Keyhole Limpet Haemocyanin (KLH) were determined in calves experimentally infected with 3000 L3 on alternate days for 6 weeks. Calves were given one of two diets, and were either infected or not infected with O. ostertagi L3. The diets were either high (H) or low (L) in protein/energy and were within the range of normal husbandry practice in the UK. Both IgG1 and IgG2, but not IgA, responses to L3 antigen were increased in the L-diet compared with the H-diet. IgA responses to L3 antigen were not affected by dietary treatment. The effects of diet and infection on anti-KLH IgG1 were independent of each other; IgG1 anti-KLH responses were decreased by infection and by the L-diet compared with the H-diet. The data suggest that there is a strong interrelationship between diet and immunity during nematode infections.
Mansour
M M
MM
Department of Veterinary Pathology, University of Liverpool, UK.
Dixon
J B
JB
Rowan
T G
TG
Carter
S D
SD
D000818:Animals; D000909:Antibodies, Helminth / Q000096:biosynthesis / Q000276:immunology*; D002417:Cattle; D002418:Cattle Diseases / Q000178:diet therapy / Q000276:immunology*; D004044:Dietary Proteins / Q000008:administration & dosage*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D006433:Hemocyanins / Q000276:immunology; D007109:Immunity; D007136:Immunoglobulins / Q000096:biosynthesis; D008297:Male; D010028:Ostertagia / Q000276:immunology*; D010029:Ostertagiasis / Q000178:diet therapy / Q000276:immunology / Q000662:veterinary*
D000909:Antibodies, Helminth; D004044:Dietary Proteins; D007136:Immunoglobulins; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin