[Analysis of frequency of DR3 allele in rapidly evolutive forms of Crohn disease in adults; comparison with the occurrence of this allele in slowly evolutive forms and in the normal population].
This communication reports 1. the frequency of the DR3 allele among 86 patients exhibiting various evolutive courses of Crohn's disease (CD), diagnosed in the same hospital in Alsace, France, hospitalized at least once between 1964 and 1986 and followed for at least 1 year, 2. the frequency of the DR3 allele among a control population in the same area: 126 volunteers donors of bone marrow. The definition of the evolutive course was similar to the one published by Binder et al.: slow course (including: intermittent: "occurrence of symptom-free period(s) of at least one month's duration excluding period where the patient was in steroid treatment"; and inactive: "completely free of bowel symptoms during the year") as opposed to continuous evolution: "without symptom-free periods". The DR3 allele determination was established by classical serologic analysis. 26 patients were found with the DR3 allele; 14 belonged to the slow course group, 12 to the continuous evolution group; 60 patients did not exhibit the DR3 allele: 50 in the slow course group, 10 in the continuous evolution group. chi 2 = 8.28; p = 0.004. Therefore the frequency of the DR3 allele was very significantly higher in the group with the continuous course (55%) than in the slow course group (22%). Similarly the frequency of the DR3 allele in the group with the continuous course (12/22: 55%) was significantly higher than in the group of control subjects (34/126: 28%) chi 2 = 6.64; p = 0.01.(ABSTRACT TRUNCATED AT 250 WORDS)
René
E
E
Service d'Hépato-Gastroentérologie, Hôpital Bichat, Paris.
Duclos
B
B
Lagrange
P
P
Tongio
M M
MM
Mignon
M
M
Baumann
R
R
D000328:Adult; D000483:Alleles; D003424:Crohn Disease / Q000145:classification / Q000235:genetics* / Q000503:physiopathology; D015803:HLA-DR3 Antigen / Q000235:genetics*; D006801:Humans
D015803:HLA-DR3 Antigen
Analyse de la fréquence de l'allèle DR3 dans les formes d'évolutivité rapide de la maladie de Crohn de l'adulte; comparaison à la fréquence de cet allèle dans les formes à évolution lente et dans une population témoin.