title: Sulfonylureas: a new class of cancer chemotherapeutic agents.
abstract: This study summarizes the antitumor properties of a number of sulofenur thiophene analogs against subcutaneously implanted 6C3HED lymphosarcoma with structural modification of the aryl moiety of the sulfonamide portion of the diarylsulfonylureas. The spectrum of activity of N-(p-chlorophenyl)-N'- [(5-methoxy-2-thienyl)sulfonyl]urea in the HXGC3, VRC5, CX-1, and LX-1 cell lines is also presented.
authors.affiliation: Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
authors.forename: F
authors.initials: F
authors.lastname: Mohamadi
authors.forename: M M
authors.initials: MM
authors.lastname: Spees
authors.forename: G B
authors.initials: GB
authors.lastname: Grindey
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008809:Mice, Inbred C3H; D015394:Molecular Structure; D009368:Neoplasm Transplantation; D013453:Sulfonylurea Compounds / Q000737:chemistry / Q000627:therapeutic use*; D013876:Thiophenes / Q000737:chemistry / Q000627:therapeutic use; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D013453:Sulfonylurea Compounds; D013876:Thiophenes; C058179:sulofenur