title: [Hepatic changes in patients with isolated immunodeficiency virus infection and AIDS].
abstract: BACKGROUND
  The aim of the present study was to describe the spectrum of liver disease in isolated infection by the human immunodeficiency virus and in the acquired immunodeficiency syndrome as well as evaluate whether clinical and/or biological data exist to permit specific diagnosis in liver biopsy.
  
  
  METHODS
  Liver biopsy was performed in 39 patients with the human immunodeficiency virus (34 via parenteral drug addicts), 22 of whom had established acquired immunodeficiency syndrome.
  
  
  RESULTS
  In 29 cases (74%) a specific histologic diagnosis was obtained with the changes most frequently found being the presence of granulomas (11 patients), mainly in patients with stablished AIDS, and chronic active hepatitis non A non B (10 patients), specially in the cases with isolated infection by the human immunodeficiency virus. Obtaining of a specific diagnosis was associated with an increase in GOT and a decrease of the CD4 lymphocytes and the CD4/CD8 quotient (p = 0.002 in all cases). The existence of established AIDS or prolonged fever was associated with the finding of hepatic granulomas (p = 0.02 and p = 0.002, respectively). The increase in GPT, the absence of stablished AIDS and the absence of prolonged fever was associated to the presence of chronic active hepatitis (p = 0.01, p = 0.002 and p = 0.0002, respectively).
  
  
  CONCLUSIONS
  In patients with infection by the human immunodeficiency virus liver biopsy provides diagnostic information in a high percentage of cases. The presence of established AIDS, prolonged fever, and hypertransaminasemia may point towards possible histologic diagnosis.
authors.affiliation: Servicio de Aparato Digestivo, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona.
authors.forename: X
authors.initials: X
authors.lastname: Bertrán
authors.forename: R
authors.initials: R
authors.lastname: Planas
authors.forename: J L
authors.initials: JL
authors.lastname: Mate
authors.forename: J
authors.initials: J
authors.lastname: Romeu
authors.forename: F
authors.initials: F
authors.lastname: Fernández-Bañares
authors.forename: G
authors.initials: G
authors.lastname: Sirera
authors.forename: I
authors.initials: I
authors.lastname: Ojanguren
authors.forename: E
authors.initials: E
authors.lastname: Doménech
authors.forename: E
authors.initials: E
authors.lastname: Cabré
authors.forename: M A
authors.initials: MA
authors.lastname: Gassull
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D001706:Biopsy; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008107:Liver Diseases / Q000150:complications / Q000473:pathology*; D008297:Male
vernacular_title: Alteraciones hepáticas en los pacientes con infección aislada por el virus de la inmunodeficiencia humana y con SIDA.