title: Repair of left ventricular aneurysm. Changes in ventricular mechanics, hemodynamics, and oxygen consumption.
abstract: Anteroapical left ventricular aneurysms were produced in 23 sheep by coronary arterial ligation. Plication of the aneurysm does not change stroke volume or cardiac output and does not significantly change left ventricular oxygen consumption from the preoperative value of 5.1 +/- 2.6 ml/100 gm per minute. Plication, however, does increase left ventricular end-systolic elastance from 3.2 +/- 0.9 to 4.4 +/- 1.5 mm Hg/mm (p = 0.005). In nine of these sheep the midsagittal plane of the left ventricle was imaged by means of an array of sonomicrometry crystals before and after plication of the aneurysm. Regional wall stresses at end-systole and end-diastole and changes in diastolic function were calculated for anterior and posterior ventricular walls in the border zone adjacent to the aneurysm and in more basilar myocardium remote from the infarct. Plication significantly reduced end-systolic wall stresses and systolic stress integrals in the posterior border zone and remote myocardium, but it did not significantly change anterior wall systolic stresses or stress integrals. Plication also decreased diastolic stretching of border zone myocardium. Plication of anteroapical left ventricular aneurysm produced a shorter, more spherical ventricle and removed the dyskinetic segments but altered deformation (strain) in both circumferential and longitudinal directions. The changes in ventricular wall geometry and deformation provide an explanation for the increased ventricular end-systolic elastance and unchanged stroke volume observed after aneurysm plication.
authors.affiliation: Department of Surgery, School of Medicine, University of Pennsylvania, Philadelphia.
authors.forename: E B
authors.initials: EB
authors.lastname: Savage
authors.forename: S W
authors.initials: SW
authors.lastname: Downing
authors.forename: M B
authors.initials: MB
authors.lastname: Ratcliffe
authors.forename: M
authors.initials: M
authors.lastname: Fallert
authors.forename: K B
authors.initials: KB
authors.lastname: Gupta
authors.forename: G S
authors.initials: GS
authors.lastname: Tyson
authors.forename: D K
authors.initials: DK
authors.lastname: Bogen
authors.forename: L H
authors.initials: LH
authors.lastname: Edmunds
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D002302:Cardiac Output; D003326:Coronary Circulation; D003971:Diastole; D006322:Heart Aneurysm / Q000601:surgery*; D006352:Heart Ventricles / Q000378:metabolism; D006439:Hemodynamics; D010101:Oxygen Consumption; D012756:Sheep; D013318:Stroke Volume; D013599:Systole; D016276:Ventricular Function