[Effects of polyunsaturated fatty acids on Krebs cycle in the rat kidney in chronic phosphorus intoxication].
The investigation of Krebs cycle state in kidney homogenates of August rats subjected to oral intoxication with oil solution of yellow phosphorus in a dose of 0.3 mg/kg, has shown that under conditions of balanced nutrition the activity of NAD-dependent isocitrate dehydrogenase, succinate dehydrogenase and accumulation of the substrate fund of the cycle decreased 3.5-fold as compared to the control. The addition of polyunsaturated fatty acids to the ration produced a positive effect on Krebs cycle state: dehydrogenase activity was not significantly changed, accumulation of Krebs cycle substrate was two-fold lower. However, this ration did not completely abolish the toxic action of yellow phosphorus on Krebs cycle.
Kulkybaev
G A
GA
Merkusheva
N V
NV
D000818:Animals; D002908:Chronic Disease; D002952:Citric Acid Cycle / Q000187:drug effects*; D004032:Diet; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects*; D008297:Male; D010758:Phosphorus / Q000506:poisoning*; D051381:Rats
D005231:Fatty Acids, Unsaturated; D010758:Phosphorus
Vliianie polinenasyshchennykh zhirnykh kislot na tsikl Krebsa v pochkakh krys v usloviiakh khronicheskoĭ fosfornoĭ intoksikatsii.