A case of 'auto-immune thrombocytopenic purpura' serologically similar to post-transfusion purpura.
The report describes a HPA-1a (Zwa)-negative woman with thrombocytopenia and antibodies in serum and eluate from autologous platelets with an operational anti-HPA-1a specificity. The results of the serological investigations were similar to the findings in most patients suffering from post-transfusion purpura. However, the present patient had no history of blood transfusion prior to the unset of purpura and the thrombocytopenia had persisted 6 months before splenectomy.
Taaning
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Department of Clinical Immunology and Blood Bank, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark.
Killmann
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SA
D016824:Antigens, Human Platelet / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology* / Q000601:surgery; D001803:Blood Transfusion; D005260:Female; D006801:Humans; D039661:Integrin beta3; D008875:Middle Aged; D009888:Opipramol / Q000009:adverse effects; D010980:Platelet Membrane Glycoproteins / Q000276:immunology*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000209:etiology / Q000276:immunology* / Q000601:surgery; D013156:Splenectomy
D016824:Antigens, Human Platelet; D001323:Autoantibodies; C061248:ITGB3 protein, human; D039661:Integrin beta3; D010980:Platelet Membrane Glycoproteins; D009888:Opipramol