Suppression by 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil of preneoplastic mammary hyperplastic alveolar nodule formation in SHN virgin mice.
It is known that hyperplastic alveolar nodule (HAN) is a representative preneoplastic state in mammary glands of mice. We examined the effect of 1-(2-tetrahydrofuryl)-5-fluorouracil and uracil (UFT) on HAN formation in a high mammary tumour strain of SHN virgin mice. Oral administration of UFT for 5 months beginning at one month of age significantly reduced the number of HAN and DNA-synthesizing enzyme activities in the mammary glands. These results indicate that long-term administration of low dose UFT reduces the de novo and salvage synthesis of DNA and suppresses preneoplastic HAN.
Sakamoto
S
S
Medical Research Institute, Tokyo Medical and Dental University, Japan.
Mizuno
M
M
Sawaki
K
K
Kudo
H
H
Kasahara
N
N
Suzuki
S
S
Mori
T
T
Nagasawa
H
H
D000818:Animals; D005260:Female; D006128:Growth / Q000187:drug effects; D006965:Hyperplasia / Q000188:drug therapy / Q000201:enzymology; D008321:Mammary Glands, Animal / Q000201:enzymology / Q000473:pathology*; D015674:Mammary Neoplasms, Animal / Q000188:drug therapy* / Q000201:enzymology; D051379:Mice; D008815:Mice, Inbred Strains; D011230:Precancerous Conditions / Q000188:drug therapy* / Q000201:enzymology; D005641:Tegafur / Q000008:administration & dosage / Q000627:therapeutic use*; D013937:Thymidine Kinase / Q000378:metabolism; D013940:Thymidylate Synthase / Q000378:metabolism; D014498:Uracil / Q000627:therapeutic use*
D005641:Tegafur; D014498:Uracil; D013940:Thymidylate Synthase; D013937:Thymidine Kinase