Telogen effluvium due to recombinant interferon alpha-2b.
Five of 10 patients receiving long-term recombinant interferon alpha-2b therapy complained of considerable hair loss. The pull test and the trichogram showed a telogen count consistent with a telogen effluvium. In 2 patients the telogen count progressively improved despite continuing the treatment, whereas in 3 patients the trichogram continued to show an increased telogen count until interferon therapy was discontinued. Pohl-Pinkus hair constrictions were also present in 2 patients.
Tosti
A
A
Department of Dermatology, University of Bologna, Italy.
Misciali
C
C
Bardazzi
F
F
Fanti
P A
PA
Varotti
C
C
D000328:Adult; D000368:Aged; D000505:Alopecia / Q000139:chemically induced*; D005260:Female; D006197:Hair / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins