[Choice of quantitative characteristics of a radiation modifier affinity and the range of its pharmacological action (minireview)].
On the basis of the literature the necessity of using not only DMF and maximal protective or sensitizing effects, but also the affinity and the range of the pharmacological action of radiation modifiers is argued. The affinity is worth while to expressed as ED50 (the dose that produces a half of the maximal effect), and the range of the pharmacological action as a therapeutic index K = LD50/ED50.
Kulinskiĭ
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Kovtun
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D000818:Animals; D006801:Humans; D008962:Models, Theoretical; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000633:toxicity; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage / Q000633:toxicity
D011837:Radiation-Protective Agents; D011838:Radiation-Sensitizing Agents
O vybore kolichestvennykh kharakteristik srodstva radiomodifikatora i shiroty ego farmakologicheskogo deĭstviia (minilitobzor).