[Does hormonal activity of pheochromocytoma affect long-term prognosis in surgically treated patients?].
89 patients were operated upon for pheochromocytoma. 61 patients (37 women and 24 men) were available for follow-up. Mean age at operation was 39 +/- 12.3 yrs. Before operation paroxysmal and sustained hypertension were observed in 34 (55.7%) and 27 (44.3%) patients, respectively. Postoperatively permanent normalization of blood pressure was achieved in 38 cases (62.3%). All patients were divided into four groups. Group I with increased urine excretion of noradrenaline (NA) and adrenaline (A) consisted of 19 (31.1%) patients. Group II (increased NA excretion) included 27 (44.3%) patients. Group III comprised 3 (4.9%) cases with elevated A excretion. 12 (19.7%) patients with normal urinary excretion of catecholamines and increased excretion of methoxycatecholamines were alloted to group IV. Permanent normalization of blood pressure predominantly was observed in group IV--91.6%, whilst in group I, II and III this hypotensive effect was noted in 57.9%, 51.8% and 2/3, respectively. Permanent normalization of blood pressure can be mainly expected in patients with pheochromocytoma in whom catecholamines are rapidly inactivated within the tumor.
Wocial
B
B
Kliniki Nadciśnienia Tetniczego i Chorób Naczyń AM, Warszawie.
Pruszczyk
P
P
Feltynowski
T
T
Chodakowska
J
J
Januszewicz
W
W
D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology / Q000601:surgery; D000315:Adrenalectomy; D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D004837:Epinephrine / Q000378:metabolism* / Q000502:physiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000378:metabolism* / Q000502:physiology; D010673:Pheochromocytoma / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology / Q000601:surgery; D011379:Prognosis; D013997:Time Factors
D009638:Norepinephrine; D004837:Epinephrine
Czy aktywność hormonalna guza wpływa na odległe rokowanie u chorych z pheochromocytoma leczonych operacyjnie?