[The efficacy of Vermox and albendazole in an experimental model of nippostrongylosis in mice].
Experiments with the model of Nippostrongylus brasiliensis and white outbred mice showed that vermox and albendazole are highly effective anthelmintics in nippostrongyliasis. The ED50 of albendazole for 7 days invasion (adult worms) is 148.9 times higher than for 4 days (fourth instar larvae) and 25.1 times higher than for 2 days (third instar larvae). The ED90/ED10 ratio for albendazole is 1.4, 4.4, and 12.4 at days 7, 4, and 2, respectively. At the adult stage, susceptibility to anthelmintics (vermox and albendazole) increases with age.
Rashid
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VM
D015766:Albendazole / Q000627:therapeutic use*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D007814:Larva / Q000187:drug effects; D008463:Mebendazole / Q000627:therapeutic use*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D009349:Nematode Infections / Q000188:drug therapy* / Q000469:parasitology; D009559:Nippostrongylus / Q000187:drug effects; D013997:Time Factors
D008463:Mebendazole; D015766:Albendazole
Izuchenie éffektivnosti vermoksa i al'bendazola na éksperimental'noĭ modeli nippostrongileza mysheĭ.