title: Scoring mitotic activity in longitudinal sections of mouse embryonic incisors: significant differences exist for labial and lingual inner dental epithelia.
abstract: The incisors of rodents (e.g., mice and rats) have an enamel-free lingual surface. It is not known how position specific differential evolution of labial versus lingual inner dental epithelium (IDE) is regulated. The patterns of mitotic activity of lingual and labial preodontoblasts and IDE were determined on sagittal sections of embryonic mouse incisors. No statistical differences were observed for the preodontoblasts. On the other hand the lingual IDE withdraw from the cell cycle before the corresponding labial cells. The incapacity of lingual IDE to differentiate into functional ameloblasts might be a consequence of a failure of cell kinetic dependent acquisition of competence to respond to specific epigenetic control mechanisms.
authors.affiliation: Institut de Biologie Médicale, Faculté de Médecine, Strasbourg, France.
authors.forename: M
authors.initials: M
authors.lastname: Nso
authors.forename: B
authors.initials: B
authors.lastname: Senger
authors.forename: J V
authors.initials: JV
authors.lastname: Ruch
mesh_terms: D000818:Animals; D002452:Cell Count; D002453:Cell Cycle; D002454:Cell Differentiation; D007180:Incisor / Q000196:embryology*; D051379:Mice; D008940:Mitotic Index; D009804:Odontoblasts / Q000166:cytology; D009805:Odontogenesis; D014083:Tooth Germ / Q000196:embryology