Conjunctival epithelial cells from patients with Sjögren's syndrome inappropriately express major histocompatibility complex molecules, La(SSB) antigen, and heat-shock proteins.
The La(SSB) antigen has been detected within the cytoplasm and on the membrane of conjunctival cells (CC) from patients with Sjögren's syndrome, whereas it was weakly expressed in the nucleus of normal cells. The diseased CC were shown to overproduce major histocompatibility complex (MHC) class I antigens and express MHC class II antigens. Anti-heat-shock protein monoclonal antibody bound to the cell membrane in patients but not in normal controls.
Yannopoulos
D I
DI
Laboratory of Immunology, Brest University Medical School, France.
Roncin
S
S
Lamour
A
A
Pennec
Y L
YL
Moutsopoulos
H M
HM
Youinou
P
P
D001324:Autoantigens / Q000096:biosynthesis; D003228:Conjunctiva / Q000276:immunology*; D004848:Epithelium / Q000276:immunology; D006360:Heat-Shock Proteins / Q000096:biosynthesis*; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis*; D000949:Histocompatibility Antigens Class II / Q000096:biosynthesis; D006801:Humans; D007124:Immunoenzyme Techniques; D012261:Ribonucleoproteins; D012859:Sjogren's Syndrome / Q000276:immunology*; D000097585:SS-B Antigen
D001324:Autoantigens; D006360:Heat-Shock Proteins; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D012261:Ribonucleoproteins; D000097585:SS-B Antigen