Mutations in signal transduction pathways and inherited diseases.
Intracellular signal transduction pathways have central roles in processes such as growth, differentiation, neurotransmission and development. The aberrant expression of components of various signal transduction pathways has profound consequences for cellular functions. Recent findings indicate that many cases of neoplasia and inherited diseases have, at their roots, mutations in key steps of signalling pathways.
Sassone-Corsi
P
P
CNRS-INSERM, Strasbourg, France.
Borrelli
E
E
D000818:Animals; D019204:GTP-Binding Proteins / Q000235:genetics*; D020690:GTPase-Activating Proteins; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D006801:Humans; D009154:Mutation; D015689:Oncogene Protein p21(ras); D011506:Proteins; D015398:Signal Transduction / Q000235:genetics*; D020703:ras GTPase-Activating Proteins
D020690:GTPase-Activating Proteins; D011506:Proteins; D020703:ras GTPase-Activating Proteins; D019204:GTP-Binding Proteins; D015689:Oncogene Protein p21(ras)