title: The gene encoding the human spasmolytic protein (SML1/hSP) is in 21q 22.3, physically linked to the homologous breast cancer marker gene BCEI/pS2.
abstract: The human spasmolytic protein, SML1/hSP, an inhibitor of spasmolytic activity and gastric acid secretion in the pig, has been shown to exhibit homology to the pS2 protein, an estrogen-dependent breast cancer marker. Moreover, SML1/hSP and pS2 are expressed at the same localization in the normal stomach and during healing of the gastrointestinal tract. Here we report the chromosomal localization, obtained by in situ hybridization, of the hSP gene (SML1) to chromosome 21 at 21q22.3. Using pulsed-field gel electrophoresis, we found SML1 to be within 230 kb of the BCEI/pS2 gene.
authors.affiliation: LGME/CNRS, Institut de Chimie Biologique, Faculté de Médecine, Strasbourg, France.
authors.forename: C
authors.initials: C
authors.lastname: Tomasetto
authors.forename: N
authors.initials: N
authors.lastname: Rockel
authors.forename: M G
authors.initials: MG
authors.lastname: Mattei
authors.forename: R
authors.initials: R
authors.lastname: Fujita
authors.forename: M C
authors.initials: MC
authors.lastname: Rio
mesh_terms: D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000235:genetics*; D002874:Chromosome Mapping; D002891:Chromosomes, Human, Pair 21; D016521:Electrophoresis, Gel, Pulsed-Field; D004967:Estrogens / Q000378:metabolism; D008040:Genetic Linkage; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D007621:Karyotyping; D008677:Metaphase; D009077:Mucins; D009124:Muscle Proteins; D009363:Neoplasm Proteins / Q000235:genetics*; D009479:Neuropeptides; D010455:Peptides / Q000235:genetics*; D011506:Proteins; D012689:Sequence Homology, Nucleic Acid; D000071163:Trefoil Factor-1; D000071164:Trefoil Factor-2; D000071165:Trefoil Factor-3; D025521:Tumor Suppressor Proteins
chemical_list: D014408:Biomarkers, Tumor; D004967:Estrogens; D036341:Intercellular Signaling Peptides and Proteins; D009077:Mucins; D009124:Muscle Proteins; D009363:Neoplasm Proteins; D009479:Neuropeptides; D010455:Peptides; D011506:Proteins; C051838:TFF1 protein, human; C000604007:TFF2 protein, human; C099037:TFF3 protein, rat; D000071163:Trefoil Factor-1; D000071164:Trefoil Factor-2; D000071165:Trefoil Factor-3; D025521:Tumor Suppressor Proteins; C034407:pancreatic spasmolytic polypeptide