Correlation between a hepatic copper accumulation and an altered expression of glutathione S-transferase Ya/Yc subunits in LEC mutant rat.
Long-Evans Cinnamon (LEC) rat, an animal model of Wilson's disease, that develops a necrotizing hepatic injury with an abnormally high hepatic copper accumulation exhibits an altered expression of glutathione S-transferase (GST) subunits, that is, a low percentage of the Ya and a high percentage of the Yc subunit expression in males. The altered expression of GST subunits and the abnormal copper accumulation in liver were found to be completely correlated in male LEC mutant rat liver, suggesting that the copper toxicity caused by the anomaly of copper metabolism in LEC rat liver leads to the altered expression of GST subunits.
Yamada
T
T
Institute for Animal Experimentation, University of Tokushima School of Medicine, Japan.
Izumi
K
K
Suzuki
Y
Y
Agui
T
T
Matsumoto
K
K
D000818:Animals; D003300:Copper / Q000378:metabolism*; D004195:Disease Models, Animal; D015870:Gene Expression; D005982:Glutathione Transferase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006527:Hepatolenticular Degeneration / Q000235:genetics / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D010641:Phenotype; D011487:Protein Conformation; D051381:Rats; D011914:Rats, Inbred BN; D011922:Rats, Mutant Strains
D003300:Copper; D005982:Glutathione Transferase