title: Uterine leiomyoma cytogenetics. III. Interphase cytogenetic analysis of karyotypically normal uterine leiomyoma excludes possibility of undetected trisomy 12.
abstract: Uterine leiomyoma, a benign tumor that histopathologically is rather homogeneous, was recently characterized cytogenetically. About 40% of the investigated tumors are associated with clonal chromosome abnormalities and five different subgroups have been identified, characterized by trisomy 12, t(12;14)(q14-15;q23-24), del(7q), t(1;2)(p36;p24), and 6p rearrangements. In our survey of 76 cases, trisomy 12 was observed in 10% of the abnormal cases. To exclude a possible underscoring of this abnormality, we reexamined 15 of the cases with normal karyotype by interphase cytogenetics using a chromosome 12 alphoid DNA probe.
authors.affiliation: Istituto di Biologia Generale, Università degli Studi, Cagliari, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Vanni
authors.forename: N
authors.initials: N
authors.lastname: Van Roy
authors.forename: U
authors.initials: U
authors.lastname: Lecca
authors.forename: F
authors.initials: F
authors.lastname: Speleman
mesh_terms: D002881:Chromosomes, Human, Pair 12; D015342:DNA Probes / Q000235:genetics; D005260:Female; D005453:Fluorescence; D006801:Humans; D007399:Interphase / Q000235:genetics; D007621:Karyotyping; D007889:Leiomyoma / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D014314:Trisomy; D014594:Uterine Neoplasms / Q000235:genetics*
chemical_list: D015342:DNA Probes