[Quantitative analysis of urinary organic acid].
We showed the optimum conditions for analysis of urinary organic acids using solvent extraction and GC/MS by the stable isotope dilution technique. Examples of the diagnosis in a case of heterozygote of ornithine transcarbamylase deficiency and a case of multiple carboxylase deficiency were described. The accurate quantitative analysis of urinary organic acids with stable isotope dilution technique is necessary for routine examination conducted in clinical laboratories.
Shimizu
A
A
Department of Clinical Pathology, Osaka Medical College, Takatsuki.
Nakanishi
T
T
D005260:Female; D006801:Humans; D007223:Infant; D013058:Mass Spectrometry; D009100:Multiple Carboxylase Deficiency / Q000652:urine*; D009954:Ornithine Carbamoyltransferase / Q000652:urine*; D020163:Ornithine Carbamoyltransferase Deficiency Disease; D016482:Urinalysis
D009954:Ornithine Carbamoyltransferase