title: Comparative trial on the response of Plasmodium falciparum to halofantrine and mefloquine in Trat Province, eastern Thailand.
abstract: With the appearance of strains of Plasmodium falciparum in the Trat Province, eastern Thailand, reported to have developed resistance to mefloquine there is a need for an alternative drug. This comparative trial with mefloquine and halofantrine has demonstrated extremely low cure rates with both drugs (33.3% and 28.13% respectively), cross-resistance is suggested.
authors.affiliation: Department of Communicable Disease Control, Ministry of Public Health, Bangkok, Thailand.
authors.forename: S
authors.initials: S
authors.lastname: Ketrangsee
authors.forename: S
authors.initials: S
authors.lastname: Vijaykadga
authors.forename: P
authors.initials: P
authors.lastname: Yamokgul
authors.forename: S
authors.initials: S
authors.lastname: Jatapadma
authors.forename: K
authors.initials: K
authors.lastname: Thimasarn
authors.forename: W
authors.initials: W
authors.lastname: Rooney
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000962:Antimalarials / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology; D008297:Male; D015767:Mefloquine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010616:Phenanthrenes / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013785:Thailand / Q000453:epidemiology; D016896:Treatment Outcome
chemical_list: D000962:Antimalarials; D010616:Phenanthrenes; C023768:halofantrine; D015767:Mefloquine