title: Conspicuous ingestion of Staphylococcus aureus organisms by murine fibroblasts in vitro.
abstract: A conspicuous adhesion of Staphylococcus aureus organisms to murine cutaneous fibroblasts and NIH/3T3 cells cultured in vitro and subsequent ingestion of S. aureus organisms by these fibroblasts are described. In the present experimental system, only fibroblasts-adhering S. aureus organisms were efficiently ingested by fibroblasts unlike S. epidermidis and S. saprophyticus. These findings might suggest a correlation between the pathogenesis of S. aureus and its intracellular localization in non-professional phagocytes such as fibroblasts in a special reference to its higher pathogenicity than those of coagulase negative counterparts.
authors.affiliation: Department of Bacteriology, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Usui
authors.forename: M
authors.initials: M
authors.lastname: Murai
authors.forename: K
authors.initials: K
authors.lastname: Seki
authors.forename: J
authors.initials: J
authors.lastname: Sakurada
authors.forename: S
authors.initials: S
authors.lastname: Masuda
mesh_terms: D016475:3T3 Cells / Q000276:immunology; D000818:Animals; D001422:Bacterial Adhesion / Q000276:immunology; D002478:Cells, Cultured; D005347:Fibroblasts / Q000276:immunology* / Q000648:ultrastructure; D007700:Kinetics; D051379:Mice; D010587:Phagocytosis / Q000276:immunology*; D012867:Skin / Q000276:immunology; D013211:Staphylococcus aureus / Q000276:immunology* / Q000648:ultrastructure