title: Brofaromine in panic disorder: a pilot study with a new reversible inhibitor of monoamine oxidase-A.
abstract: The therapeutic efficacy of brofaromine--a new reversible and short acting MAO-A inhibitor--was evaluated in 14 inpatients with a panic disorder. In an open trial, the patients were treated with placebo during the first week and with 150 mg brofaromine per day during the following four weeks. In all patients a distinct improvement in both anxiety and depressive symptoms was observed under the active drug. Treatment outcome was the same in patients with and without a concomitant major depressive episode. No side-effects of any note were reported. Our findings suggest that the MAO-A inhibitor brofaromine is an effective drug in the treatment of anxiety disorders.
authors.affiliation: Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Garcia-Borreguero
authors.forename: C J
authors.initials: CJ
authors.lastname: Lauer
authors.forename: A
authors.initials: A
authors.lastname: Ozdaglar
authors.forename: K
authors.initials: K
authors.lastname: Wiedemann
authors.forename: F
authors.initials: F
authors.lastname: Holsboer
authors.forename: J C
authors.initials: JC
authors.lastname: Krieg
mesh_terms: D000328:Adult; D000379:Agoraphobia / Q000188:drug therapy / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D016584:Panic Disorder / Q000188:drug therapy* / Q000523:psychology; D010880:Piperidines / Q000009:adverse effects / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales
chemical_list: D008996:Monoamine Oxidase Inhibitors; D010880:Piperidines; C038213:brofaromine; D008995:Monoamine Oxidase