[Reconstruction-plasty of iatrogenic choledochal stenoses using human pericardium. An experimental study in the domestic pig].
The effect of human pericardial patch plastic for reconstruction of iatrogenic common bile duct stenosis was investigated in experiments performed in pigs. All patches (n = 8) were overgrown with immature biliary epithelium detectable on light and electron microscopy within 6 weeks. No restenosis nor any fistula developed during this observation period. Liver function tests, especially bilirubin, were not suitable parameters for the detection of biliary obstruction (preoperative value 0.38 +/- 0.09 mg/dl; 1 week after subtotal stenosis 3.36 +/- 1.53 mg/dl; 2 weeks after subtotal stenosis 1.49 +/- 0.62 mg/dl; 3 weeks after subtotal stenosis 0.50 +/- 0.27 mg/dl; 6 weeks after pericardial patch plastic 0.33 +/- 0.05 mg/dl, mean +/- SD. Ultrasonographic measurement of the common bile duct diameter was the diagnostic method of choice. Preoperative dimension 4.5 +/- 0.5 mm; 1 week after subtotal stenosis 8.5 +/- 2.0 mm; 2 weeks after subtotal stenosis 10.5 +/- 1.8 mm; 3 weeks after subtotal stenosis 14.0 +/- 3.6 mm; 6 weeks after pericardial patch plastic 9.0 +/- 1.6 mm, mean +/- SD.
Lexer
G W
GW
Ludwig-Boltzmann-Institut für experimentelle und gastroenterologische Chirurgie, Landeskrankenanstalten Salzburg.
Zukriegel
M
M
Meiser
G
G
Kaindl
H
H
Waclawiczek
H W
HW
Pimpl
W
W
Boeckl
O
O
D000818:Animals; D001705:Bioprosthesis; D001651:Cholestasis, Extrahepatic / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D003135:Common Bile Duct / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D003137:Common Bile Duct Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D004848:Epithelium / Q000473:pathology; D008111:Liver Function Tests; D008855:Microscopy, Electron, Scanning; D010496:Pericardium / Q000637:transplantation*; D013536:Suture Techniques; D013552:Swine; D014463:Ultrasonography; D014945:Wound Healing / Q000502:physiology
Erweiterungsplastik von iatrogenen Choledochusstenosen mit Humanperikard. Experimentelle Studie am Hausschwein.