title: Fibrinous uveitis and intraocular lens implantation. Surface modification of polymethylmethacrylate during extracapsular cataract surgery.
abstract: BACKGROUND
  The causes of fibrinous uveitis after cataract surgery are unclear, but surface modification of polymethylmethacrylate (PMMA) is known to influence post-operative inflammation. One hundred twenty-five patients were entered into a prospective investigation designed to assess the effect of intraoperative surface modification of PMMA, by coating with a 2% hydroxypropyl methylcellulose solution, on the incidence of fibrinous uveitis after extracapsular cataract surgery and lens implantation.
  
  
  METHODS
  Of the 125 patients entered into this prospective study, 90 received pretreatment with a 1% indomethacin solution.
  
  
  RESULTS
  Fibrinous uveitis developed in 18(33%) of 54 eyes with dry lens implantation and in 1 (3%) of 36 eyes with coated lens implantation (P less than 0.005). Thirty-five eyes were not pretreated with indomethacin, and fibrin formation occurred in 6 (30%) of 20 dry implanted eyes and in 0 of 15 eyes with coated lens implantation (S = 0.02).
  
  
  CONCLUSIONS
  Intraoperative modification of the PMMA surface of an intraocular lens during implantation significantly reduces the severity of postoperative inflammation, as manifest by the incidence of fibrinous uveitis.
authors.affiliation: Moorfields Eye Hospital, London, England.
authors.forename: G E
authors.initials: GE
authors.lastname: Rose
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002387:Cataract Extraction / Q000009:adverse effects*; D005260:Female; D005337:Fibrin; D006801:Humans; D065347:Hypromellose Derivatives; D015994:Incidence; D007213:Indomethacin / Q000008:administration & dosage; D007910:Lenses, Intraocular; D008297:Male; D008747:Methylcellulose / Q000031:analogs & derivatives*; D020366:Methylmethacrylate; D008768:Methylmethacrylates; D008875:Middle Aged; D011446:Prospective Studies; D013499:Surface Properties; D014605:Uveitis / Q000209:etiology / Q000517:prevention & control*; D014792:Visual Acuity
chemical_list: D008768:Methylmethacrylates; D020366:Methylmethacrylate; D065347:Hypromellose Derivatives; D005337:Fibrin; D008747:Methylcellulose; D007213:Indomethacin