title: Stereological studies of the parathyroid gland of phosphate-treated golden hamsters subjected to a hypergravity environment.
abstract: The ultrastructure of the parathyroid glands of phosphate-treated golden hamsters exposed to a 5-G environment was studied. In the phosphate-treated animals exposed to a hypergravity environment, the Golgi complexes associated with numerous prosecretory granules, and the enlarged intercellular spaces containing floccular or finely particulate material showed a significant increase compared to those of the control, centrifuged, and phosphate-treated groups, and the cisternae of the granular endoplasmic reticulum showed a significant increase compared to those of the control and phosphate-treated groups. In addition, numerous secretory granules were situated close to the plasma membrane of chief cells in the phosphate-treated animals exposed to a hypergravity environment. These findings suggest that the synthesis, and to a greater extent the release of secretory granules may be markedly stimulated, in the parathyroid glands of phosphate-treated animals exposed to a hypergravity environment.
authors.affiliation: Department of Anatomy, Gifu University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Shoumura
authors.forename: S
authors.initials: S
authors.lastname: Emura
authors.forename: M
authors.initials: M
authors.lastname: Utsumi
authors.forename: T
authors.initials: T
authors.lastname: Yamahira
authors.forename: D
authors.initials: D
authors.lastname: Hayakawa
authors.forename: K
authors.initials: K
authors.lastname: Terasawa
authors.forename: A
authors.initials: A
authors.lastname: Tamada
authors.forename: M
authors.initials: M
authors.lastname: Arakawa
authors.forename: H
authors.initials: H
authors.lastname: Isono
mesh_terms: D000818:Animals; D002118:Calcium / Q000097:blood; D006224:Cricetinae; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D006112:Gravitation; D008247:Lysosomes / Q000648:ultrastructure; D008297:Male; D008647:Mesocricetus; D008854:Microscopy, Electron; D010280:Parathyroid Glands / Q000187:drug effects / Q000648:ultrastructure*; D010710:Phosphates / Q000494:pharmacology*; D012016:Reference Values; D014617:Vacuoles / Q000648:ultrastructure
chemical_list: D010710:Phosphates; D002118:Calcium