Effects of a gastric mucosal protecting agent in rats with liver cirrhosis.
Male Sprague-Dawley rats were fed a 0.1% ethionine-added choline-deficient diet for 8 weeks to induce liver cirrhosis. At the same time 100 mg/kg/day teprenone was administered orally in order to evaluate its effects on the liver and gastric mucosal blood flow. Blood flow increased not only in gastric mucosa but also in liver tissues in the teprenone group. Serum transaminase levels and histopathologic findings of the liver also improved. These findings suggest that teprenone alleviates hepatocellular injuries. This effect may be partly attributable to cytoprotective effects of the catenoid isoprenoid moiety of teprenone on liver cells.
Kurihara
T
T
Institute of Geriatrics, Tokyo Women's Medical College, Japan.
Akimoto
M
M
Kurokawa
K
K
Ishiguro
H
H
Niimi
A
A
Maeda
A
A
Shigemoto
M
M
Yamashita
K
K
Yokoyama
I
I
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004224:Diterpenes / Q000627:therapeutic use*; D005753:Gastric Mucosa / Q000098:blood supply*; D008099:Liver / Q000098:blood supply* / Q000473:pathology; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D008111:Liver Function Tests; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects
D000897:Anti-Ulcer Agents; D004224:Diterpenes; C031049:geranylgeranylacetone