Dynamic studies of gadolinium uptake in brain tumors using inversion-recovery echo-planar imaging.
Echo-planar imaging has been used to observe the dynamics of Gd-DTPA uptake in brain tumors. It has been possible to examine both vascular uptake and diffusion across the blood-brain barrier in a single experiment, by using the IR-MBEST echo-planar sequence which combines a high temporal resolution (approximately 3 s) with strong T1 weighting. To model the uptake it is necessary to know the arterial concentration of Gd-DTPA; in this study the signal in the sagittal sinus was measured to avoid the need to take repeated blood samples. The time constant for transfer across the blood-brain barrier was measured to be between 20 and 1050 s for different tumors. The results of the modeling correlated with the results of other assessments of tumor vascularity.
Gowland
P
P
Department of Physics, University of Nottingham, United Kingdom.
Mansfield
P
P
Bullock
P
P
Stehling
M
M
Worthington
B
B
Firth
J
J
D000328:Adult; D000368:Aged; D001812:Blood-Brain Barrier; D001932:Brain Neoplasms / Q000098:blood supply* / Q000378:metabolism*; D002199:Capillary Permeability; D002560:Cerebrovascular Circulation; D003287:Contrast Media / Q000008:administration & dosage; D004058:Diffusion; D005682:Gadolinium / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds / Q000008:administration & dosage; D004369:Pentetic Acid / Q000008:administration & dosage; D012039:Regional Blood Flow; D013382:Subtraction Technique
D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA