Lack of toxicity of intravitreally administered interferon alpha-2a.
We investigated the toxicity of single doses of intravitreally administered interferon alpha-2a in albino rabbits. Following injection of interferon in doses of 40,000, 80,000, 160,000, 320,000, and 640,000 IU/0.1 mL, no significant histologic changes were detected by light and electron microscopy. Photopic and scotopic electroretinography showed no alteration of retinal function.
Karaçorlu
M A
MA
School of Medicine, LSU Eye Center, New Orleans 70112.
Peyman
G A
GA
Cruz
S
S
Soike
K F
KF
D000818:Animals; D003623:Dark Adaptation; D004596:Electroretinography; D007267:Injections; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage / Q000633:toxicity*; D008027:Light; D011817:Rabbits; D011994:Recombinant Proteins; D012160:Retina / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D014822:Vitreous Body
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins