The prevalence of selective IgA deficiency in type 1 diabetes mellitus.
A significant increase in the prevalence of selective IgA deficiency has been observed in patients with autoimmune disorders such as systemic lupus erythematosus and rheumatoid arthritis. Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease and susceptibility to both IDDM and IgA deficiency is associated with HLA DQB1 alleles encoding non-Asp amino acids at position 57. In order to assess whether the prevalence of selective IgA deficiency is increased in IDDM, we have screened a homogeneous series of adult patients with IDDM for selective IgA deficiency. One patient (1:261) was found to have a selective IgA deficiency. The prevalence of selective IgA deficiency among adult French blood donors is 1:1400. Thus, although IDDM and selective IgA deficiency are both associated with the presence of non-Asp amino acids at position 57 of the HLA DQ beta chain, the frequency of this immunodeficiency in adult IDDM patients is not significantly increased.
Liblau
R S
RS
Department of Clinical Immunology, INSERM U 25, Necker Hospital, Paris, France.
Caillat-Zucman
S
S
Fischer
A M
AM
Bach
J F
JF
Boitard
C
C
D001327:Autoimmune Diseases / Q000150:complications / Q000453:epidemiology / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D004406:Dysgammaglobulinemia / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D006683:HLA-DQ Antigens / Q000737:chemistry; D059866:HLA-DQ beta-Chains; D006720:Homozygote; D006801:Humans; D017098:IgA Deficiency; D015995:Prevalence
D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C057615:HLA-DQbeta antigen