[Cyclosporine. Obscure sides of cardiac and pulmonary transplantations].
Cyclosporine therapy after heart and lung transplantation implies a number of specific aspects such as: kidney deficiency associated to heart failure, which delays its use as for cardiac transplantation; intestinal absorption disturbances that could be linked to the cystic fibrosis disease for lung transplantation. For both types of transplantation, local efficiency could indicate an interesting, but still unexplored therapeutic effect. Finally, it seems that the immunosuppressive effect could be linked to important pharmacological effect on calcium and could explain the specific aspects of rejection of patients under cyclosporine.
Dureau
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Hôpital Cardiovasculaire et Pneumologique Louis Pradel, Lyon.
D016572:Cyclosporine / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D006084:Graft Rejection / Q000517:prevention & control; D016027:Heart Transplantation / Q000379:methods*; D006801:Humans; D007166:Immunosuppressive Agents / Q000378:metabolism; D016040:Lung Transplantation / Q000379:methods*
D007166:Immunosuppressive Agents; D016572:Cyclosporine
Ciclosporine. Les points d'ombre en transplantations cardiaque et pulmonaire.