Oncogenes in ovarian cancer.
The discovery of cancer-causing genes has provided us with the exciting opportunity to begin to understand the molecular pathology of ovarian cancer. Activation of several of these genes including HER-2/neu, myc, ras, and p53 has been described in some ovarian cancers (Table 2). In addition, some proto-oncogenes such as the EGF receptor (erbB) and the M-CSF receptor (fms) are expressed along with their respective ligands in some ovarian cancers. Finally, for every oncogene that has been studied in ovarian cancer, there are at least a half-dozen that remain unexplored. In the future, when we have a better understanding of the molecular pathology involved in the development of ovarian cancer, this may allow us to better diagnose and treat, and eventually prevent, ovarian cancer.
Berchuck
A
A
Division of Gynecologic Oncology, Duke University Medical Center, Durham, North Carolina.
Kohler
M F
MF
Bast
R C
RC
D005260:Female; D019204:GTP-Binding Proteins / Q000502:physiology; D016147:Genes, Tumor Suppressor; D006801:Humans; D009857:Oncogenes; D010051:Ovarian Neoplasms / Q000201:enzymology / Q000235:genetics*; D011505:Protein-Tyrosine Kinases / Q000502:physiology
D011505:Protein-Tyrosine Kinases; D019204:GTP-Binding Proteins