title: Rapid eye movement sleep deprivation in elderly patients with concurrent symptoms of depression and dementia.
abstract: Rapid eye movement (REM) sleep measures distinguish elderly patients with depression from those with dementia. The authors used a 2-night REM sleep deprivation (RSD) protocol to characterize patients with mixed symptoms of depression and dementia in comparison with patients with "pure" depression or dementia and healthy controls. Mixed-symptom patients resembled dementia patients in baseline sleep measures, but their large change in phasic REM activity following RSD suggests neurobiological similarities to depression. Mixed-symptom patients with stable cognitive impairment had greater REM sleep rebound than those with a more progressive dementing course. These results are consistent with previous neuropathological and neurochemical data.
authors.affiliation: Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213.
authors.forename: D J
authors.initials: DJ
authors.lastname: Buysse
authors.forename: C F
authors.initials: CF
authors.lastname: Reynolds
authors.forename: C C
authors.initials: CC
authors.lastname: Hoch
authors.forename: P R
authors.initials: PR
authors.lastname: Houck
authors.forename: S R
authors.initials: SR
authors.lastname: Berman
authors.forename: J
authors.initials: J
authors.lastname: Matzzie
authors.forename: D J
authors.initials: DJ
authors.lastname: Kupfer
mesh_terms: D000368:Aged; D002540:Cerebral Cortex / Q000503:physiopathology; D003700:Delta Rhythm; D003704:Dementia / Q000503:physiopathology* / Q000523:psychology / Q000628:therapy; D003866:Depressive Disorder / Q000503:physiopathology* / Q000523:psychology / Q000628:therapy; D004569:Electroencephalography / Q000295:instrumentation; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D011930:Reaction Time / Q000502:physiology; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation; D012892:Sleep Deprivation / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology*