Genetic control of eosinophilia in guinea pig strains inbred for high or low bronchial allergic reactivity. 2. A genetic study of spontaneous and immunization-induced eosinophilia.
In 4 inbred strains of guinea pig the tendency to develop peripheral high-eosinophilia was shown to be genetically controlled. The development of eosinophilia with age and following immunization was examined in high- and low-eosinophilic parental strains, in F1-hybrids and in backcross offspring. The results show that probably only one or a very few segregating genes control eosinophilia, and they also indicate that different genes are involved in the determination of spontaneous (age-related) and immunization-induced eosinophilia.
Winthereik
M P
MP
Institute of Medical Microbiology, University of Copenhagen, Denmark.
Spärck
J V
JV
Lundberg
L
L
Sompolinsky
D
D
D000818:Animals; D001249:Asthma / Q000235:genetics*; D004195:Disease Models, Animal; D004802:Eosinophilia / Q000235:genetics*; D005260:Female; D006168:Guinea Pigs / Q000235:genetics*; D007114:Immunization; D008297:Male