[Effect of insulin-like growth factor I (IGF-I) on Sertoli cell metabolism in the pubescent rat].
The influence of Insulin-like Growth Factor I (IGF-I) on some metabolic functions of Sertoli cells from peripubertal rats was investigated. Sertoli cells were isolated from the testes of 24-day-old animals and cultured at 32 degrees C in Eagle's MEM with or without 1 nM IGF-I. Sertoli cells cultured in the presence of IGF-I showed increased nuclear RNA polymerase activity (+80%) and augmented protein synthesis (+50%).
Prati
M
M
Istituto di Fisiologia Generale, Università di Genova.
Palmero
S
S
De Marco
P
P
Trucchi
P
P
Fugassa
E
E
D000818:Animals; D002478:Cells, Cultured; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D008297:Male; D014176:Protein Biosynthesis; D012319:RNA Polymerase II / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012708:Sertoli Cells / Q000187:drug effects* / Q000378:metabolism; D012741:Sexual Maturation; D013268:Stimulation, Chemical
D007334:Insulin-Like Growth Factor I; D012319:RNA Polymerase II
Effetti del fattore di crescita insulino-simile I (IGF-I) sul metabolismo della cellula di Sertoli nel ratto pubere.