title: Plasma L-[18F]6-fluorodopa input function: a simplified method.
abstract: This article describes a simplified method for the determination of the L-[18F]6-fluorodopa (FDOPA) fraction time course that takes advantage of the strong correlation between the radioactivity ratio (metabolites/FDOPA) and time. Serial arterial blood samples are collected for assay of plasma total radioactivities following an intravenous injection of FDOPA into carbidopapretreated subjects. In addition, a single plasma sample, collected late in the study and analyzed for FDOPA fraction, is sufficient to determine accurately the time course of the FDOPA concentration in plasma. The validated straight-line method greatly simplifies blood analysis for routine positron emission tomography FDOPA studies.
authors.affiliation: UBC/TRIUMF, Program on Positron Emission Tomography, University of British Columbia, Vancouver, Canada.
authors.forename: G L
authors.initials: GL
authors.lastname: Chan
authors.forename: K S
authors.initials: KS
authors.lastname: Morrison
authors.forename: J E
authors.initials: JE
authors.lastname: Holden
authors.forename: T J
authors.initials: TJ
authors.lastname: Ruth
mesh_terms: D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives* / Q000097:blood; D005462:Fluorine Radioisotopes; D006801:Humans; D012044:Regression Analysis; D013997:Time Factors; D014055:Tomography, Emission-Computed / Q000379:methods*
chemical_list: D005462:Fluorine Radioisotopes; C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine