Nucleotide sequence analysis of an HTLV-I isolate from a Chilean patient with HAM/TSP.
Isolates of HTLV-I have been characterized from a number of different regions of the world; however, there has not been a nucleotide sequence analysis of an HTLV-I isolate from a South American country. Reported here is an individual from Chile identified with the HTLV-I-associated neurological disease HAM/TSP. The sera and the nucleic acid sequence of the HTLV-I present in peripheral blood lymphocytes from this Chilean HAM/TSP patient over a two year period are characterized. During this time, the patient's condition grew progressively worse. While the serological profile of this patient was unremarkable in comparison with other HAM/TSP patients previously described, nucleic acid sequence analysis identified two nucleotide positions which contained nucleotides unique to this Chilean isolate. The nucleotide sequence analysis also indicates that the Chilean HTLV-I isolate is more closely related to Caribbean and Japanese isolates of HTLV-I than to the African and U.S. isolates described so far.
Dekaban
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Immunology Group, John P. Robarts Research Institute, London, Ontario, Canada.
King
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Waters
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Rice
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D001483:Base Sequence; D015139:Blotting, Southern; D002460:Cell Line; D002677:Chile; D004279:DNA, Viral; D005260:Female; D015368:Human T-lymphotropic virus 1 / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D015493:Paraparesis, Tropical Spastic / Q000097:blood / Q000382:microbiology*; D016133:Polymerase Chain Reaction; D012689:Sequence Homology, Nucleic Acid; D013601:T-Lymphocytes / Q000382:microbiology
D004279:DNA, Viral