title: Synthesis and antimicrobial activity of new 5-aryl-2-hydroxy-3(2H)-pyrrolinone derivatives.
abstract: The synthesis of some 1-substituted 5-aryl-2-hydroxy-2-methoxycarbonylmethyl-3(2H)-pyrrolinones is described. The results of microbiological screening are given. They indicate that 2-methylene-3(2H)-furanone and 2-hydroxy-3(2H)-pyrrolinone derivatives exhibit a rather low antimicrobiological activity.
authors.affiliation: Pharmaceutical Institute, Faculty of Chemistry, Perm University, Russia.
authors.forename: V O
authors.initials: VO
authors.lastname: Kozminykh
authors.forename: N M
authors.initials: NM
authors.lastname: Igidov
authors.forename: E N
authors.initials: EN
authors.lastname: Kozminykh
authors.forename: Z N
authors.initials: ZN
authors.lastname: Semenova
authors.lastname: Andreichikov YuS
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D011760:Pyrrolidinones