Regulation of glucocorticoid receptor immunoreactivity in the rat hippocampus by androgenic-anabolic steroids.
To determine whether androgenic-anabolic steroids (AAS) regulate glucocorticoid receptors (GR), the effects of a mixture of three commonly abused AAS (testosterone cypionate, nandrolone decanoate and boldenone undecylenate) on GR immunoreactivity (ir), were examined in hippocampi of adrenalectomized male rats. Treatment with AAS for 1 week increased nuclear GRir in pyramidal cells of CA1, and granule cells of the dentate gyrus. These findings suggest a role for GR in the mediation of some of the CNS effects of androgenic-anabolic steroids.
Ahima
R S
RS
Department of Anatomy, Tulane University Medical School, New Orleans, LA 70112.
Harlan
R E
RE
D000315:Adrenalectomy; D045930:Anabolic Agents / Q000494:pharmacology*; D000728:Androgens / Q000494:pharmacology*; D000818:Animals; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism*; D007158:Immunologic Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011965:Receptors, Glucocorticoid / Q000378:metabolism*
D045930:Anabolic Agents; D000728:Androgens; D011965:Receptors, Glucocorticoid