title: Extrapyramidal system involvement in motor neuron disease.
abstract: Three cases of motor neuron disease (MND), in which neuropathological findings were atypical, are reported. The first case manifested widespread and severe degeneration of the spinal cord, as in spinal fibrosis. Case 2 revealed severe degeneration of the pyramidal tract with many spheroids, which made it difficult to differentiate from primary amyotrophic lateral sclerosis. The last case revealed degeneration of the nigro-pallido-luysian system, even though no clinical manifestation of extrapyramidal and/or cerebellar symptoms had been noted throughout the clinical course. In MND, degeneration might occur in various locations other than the motor system.
authors.affiliation: Department of Neurology, Kitasato University, School of Medicine, Kanagawa, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hasegawa
authors.forename: H
authors.initials: H
authors.lastname: Kowa
authors.forename: S
authors.initials: S
authors.lastname: Yagishita
mesh_terms: D000368:Aged; D001479:Basal Ganglia / Q000473:pathology; D001921:Brain / Q000473:pathology*; D001933:Brain Stem / Q000473:pathology; D005260:Female; D005917:Globus Pallidus / Q000473:pathology; D006801:Humans; D008297:Male; D008526:Medulla Oblongata / Q000473:pathology; D008636:Mesencephalon / Q000473:pathology; D008875:Middle Aged; D009046:Motor Neurons / Q000473:pathology* / Q000502:physiology; D009410:Nerve Degeneration; D009468:Neuromuscular Diseases / Q000473:pathology* / Q000503:physiopathology; D009474:Neurons / Q000473:pathology; D013116:Spinal Cord / Q000473:pathology*; D013378:Substantia Nigra / Q000473:pathology; D013787:Thalamic Nuclei / Q000473:pathology