Proposals for a new therapeutic strategy for simple Plasmodium falciparum malaria attacks in Cameroon.
From simplified in vivo tests, authors set up a cartography of the sensitivity of Plasmodium falciparum to amino-4-quinolines in Cameroon; they also evaluated the clinical and parasitological efficacy of different therapeutic protocols which make use of amino-4-quinolines, quinine, mefloquine and halofantrine. All these drugs are administered orally. They recommend maintaining home medication with chloroquine at the dose of 25 mg/kg over 3 days, conserving quinine for use in the case of a possible failure. The use of most recent antimalarials can be proposed only as a last resort.
Louis
J P
JP
Service d'Epidémiologie, OCEAC BP 288 Yaounde-Cameroun.
Hengy
C
C
Louis
F J
FJ
Gazin
P
P
Jambou
R
R
Gardon
J
J
Fadat
G
G
Trebucq
A
A
D000284:Administration, Oral; D000634:Aminoquinolines / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000655:Amodiaquine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002163:Cameroon; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D004351:Drug Resistance; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D015767:Mefloquine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D010616:Phenanthrenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D010963:Plasmodium falciparum / Q000187:drug effects*; D011803:Quinine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
D000634:Aminoquinolines; D000962:Antimalarials; D010616:Phenanthrenes; D000655:Amodiaquine; D002738:Chloroquine; D011803:Quinine; C023768:halofantrine; D015767:Mefloquine