Genetic variation in two bone-related proteins: is there an association with bone mineral density or skeletal size in postmenopausal women?
In an effort to determine if structural variation in proteins important in bone metabolism might influence bone mineral density (BMD) and thus be a determinant of susceptibility to osteoporosis in older women, the authors typed a group of 258 non-Black women (age 65-90) participating in the Study of Osteoporotic Fractures (SOF) for two polymorphic bone-related proteins, group specific component (Gc), also known as vitamin D-binding protein, and alpha 2HS glycoprotein (AHSG). These two proteins exhibit common structural variation in populations that can be detected by isoelectric focusing/immunoblotting of serum. An important function of Gc is the binding, solubilization, and transport of vitamin D sterols in the bloodstream while AHSG is a glycoprotein constituent of calcified cortical bone matrix. There are six common phenotypes of Gc and four of AHSG. Using Gc or AHSG phenotypes as categorical variables, statistical analyses were done to determine if bone mineral density of the proximal or distal radius or calcaneus differed by phenotype. Neither Gc nor AHSG phenotype demonstrated a statistically significant relationship with BMD at any site. Adjustments for age and degree of obesity did not substantively affect these results. Subsequent analyses to determine if phenotype of either of these proteins was associated with variables related to skeletal size showed an association of AHSG with height (P less than .02). This may indicate that AHSG phenotype is related to postmenopausal loss of height, or it may be a chance statistical finding.
Eichner
J E
JE
Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma, Oklahoma City 73190.
Cauley
J A
JA
Ferrell
R E
RE
Cummings
S R
SR
Kuller
L H
LH
D000368:Aged; D000369:Aged, 80 and over; D001798:Blood Proteins / Q000235:genetics*; D001824:Body Constitution / Q000235:genetics*; D015519:Bone Density / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D006801:Humans; D009825:Oklahoma; D015663:Osteoporosis, Postmenopausal / Q000453:epidemiology / Q000235:genetics*; D010641:Phenotype; D011446:Prospective Studies; D014809:Vitamin D-Binding Protein / Q000235:genetics*; D060749:alpha-2-HS-Glycoprotein
C556354:AHSG protein, human; D001798:Blood Proteins; D014809:Vitamin D-Binding Protein; D060749:alpha-2-HS-Glycoprotein