Tumor-associated tissue inflammatory reaction and eosinophilia in primary superficial bladder cancer.
In a retrospective study the data of 428 patients with primary superficial transitional cell carcinoma of the bladder were evaluated. The histologic slides were reviewed for presence of a tumor-associated tissue inflammatory reaction, especially tumor-associated eosinophilia. Tumor-associated cell infiltration was found in 23.1 percent and tumor-associated eosinophilia in 2.1 percent. Tumor-associated cell infiltration was associated with less recurrences (p = 0.01). Tumor progression rate was not significantly influenced by tumor-associated cell infiltration. Tumor-related death rate was lower in the group with tumor-associated cell infiltrate (p = 0.50). Using the Cox regression model carcinoma in situ of the tumor margin, tumor-associated cell infiltrate, and grade of differentiation appeared to be important factors in the prognosis for survival.
Flamm
J
J
Department of Urology, Wilhelminenspital, Vienna, Austria.
D000367:Age Factors; D002295:Carcinoma, Transitional Cell / Q000453:epidemiology / Q000401:mortality / Q000473:pathology*; D016009:Chi-Square Distribution; D003556:Cystitis / Q000453:epidemiology / Q000401:mortality / Q000473:pathology*; D004802:Eosinophilia / Q000453:epidemiology / Q000401:mortality / Q000473:pathology*; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000401:mortality / Q000473:pathology; D009367:Neoplasm Staging; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies; D012737:Sex Factors; D015996:Survival Rate; D001743:Urinary Bladder / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000473:pathology*