Effects of flurbiprofen and suprofen on the miotic activity of 1% acetylcholine and 0.01% carbachol.
The nonsteroidal antiinflammatory agents (NSAIAs) flurbiprofen and suprofen applied topically to reduce miosis may counteract the desired effects of miotics used during ocular surgery. In a pigmented rabbit model, 1% acetylcholine was shown to cause a greater, significant initial (for the first 30 minutes) constriction (P less than .05) than 0.01% carbachol in eyes pretreated with flurbiprofen and suprofen. From 2 to 8 hours, NSAIA pretreatment had a greater miotic effect with carbachol than with acetylcholine. There were no significant differences between flurbiprofen and suprofen on the miotic effect of carbachol or acetylcholine.
Yee
R W
RW
Department of Ophthalmology, University of Texas Health Science Center, San Antonio 78284-6230.
Kocurek
D
D
Yu
H S
HS
Smith
G
G
Lam
C
C
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D005480:Flurbiprofen / Q000494:pharmacology*; D011292:Premedication; D011680:Pupil / Q000187:drug effects*; D011817:Rabbits; D013496:Suprofen / Q000494:pharmacology*
D005480:Flurbiprofen; D002217:Carbachol; D013496:Suprofen; D000109:Acetylcholine