[Evaluation of 5 years of experimental in utero surgery for the repair of diaphragmatic hernia].
The incidence of diaphragmatic hernia in he newborn is 1:2,500 to 5,000 births. An extensive American programme of foetal surgery for in utero repair of this defect has shown that the pulmonary hypoplasia was due to compression of lung tissue by the herniated organs. This process could be interrupted be repairing the diaphragmatic defect early enough in utero (before the 28th week). The results of five years of experimental surgery for in utero correction of diaphragmatic hernia are presented here. The experimental model used was the Macaca fascicularis monkey, the pregnant female of which having several gestational and endocrine characteristics similar to those of the pregnant woman. Three different experimental programmes were carried out successively. A first series including five animals was used to experiment both surgical and anaesthetic techniques; three foetuses died in utero. The second series (10 animals) was designed to find a suitable protocol for tocolysis. One female died after surgery, and seven other foetuses also died. The third group (13 animals) was the main study group. The diaphragmatic hernia was first created surgically, and then repaired. No foetus died from the surgery. One female died before giving birth, and one offspring died shortly after birth as its mother had no milk. After the encouraging results obtained with this last series of animals, the procedure was applied to human cases, with the Hospital Ethical Committee's approval. In the first case, the foetus died postoperatively as a result of the rupture of the diaphragmatic prosthesis.(ABSTRACT TRUNCATED AT 250 WORDS)
Esteve
C
C
Département d'Anesthésie-Réanimation Chirurgicale, Hôpital Saint-Vincent-de-Paul, Paris.
Toubas
F
F
Gaudiche
O
O
Leveque
C
C
Bargy
F
F
Rouquet
Y
Y
Sapin
E
E
Murat
I
I
Saint-Maurice
C
C
D000768:Anesthesia, General / Q000379:methods; D000818:Animals; D002985:Clinical Protocols; D005260:Female; D005333:Fetus / Q000601:surgery*; D006548:Hernia, Diaphragmatic / Q000601:surgery*; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D008252:Macaca fascicularis; D008991:Monitoring, Physiologic; D011247:Pregnancy; D011295:Prenatal Care / Q000379:methods*; D012106:Research; D015145:Tocolysis / Q000379:methods
Bilan de cinq années de chirurgie expérimentale in utero pour la réparation des hernies diaphragmatiques.