[Study of the infiltrating lymphocyte subsets and transferrin receptor in gastric and colorectal carcinomas].
Infiltrating mononuclear cell (MNC) subsets and transferrin receptor (TfR) expression at the localized lesions were studied in 28 cases of gastric carcinoma and 36 cases of colorectal carcinoma by immunohistochemical technique by using a panel of monoclonal antibodies. The results showed that the percentage of T4+ cells in the infiltrating MNCs decreased while that of T8+ cells increased relatively and the T4/T8 ratios declined along with the progression of the tumor. The TfR positive rates in gastric and colorectal carcinomas were 73.08% and 100% respectively. The expressing intensity of TfR in the tumors correlated with the density of local infiltrating MNC subsets. These findings indicated that the local immune response against tumor moves toward a tendency of developing a deeper inhibitory effect during the tumor progression.
Yuan
P X
PX
Department of Pathology, Xian Medical University.
Si
L S
LS
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D016516:CD4-CD8 Ratio; D015179:Colorectal Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011990:Receptors, Transferrin / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism
D000911:Antibodies, Monoclonal; D011990:Receptors, Transferrin