Differential effects of alprazolam and buspirone upon acquisition, retention, and retrieval processes in memory.
A group of 125 healthy young adults was given a memory battery 1 hour after administration of alprazolam (0.5 and 1.0 mg), buspirone (5 and 10 mg), and placebo under single-dose, double-blind conditions. On the wordlist recall battery and a 24-hour retest, alprazolam appeared to impair acquisition and retention in dosages of 1.0 mg; buspirone did not adversely affect test performance at either dosage. On the basis of a 3-stage model of memory, a neuroantomical/neurophysiological model is proposed to explain the selective effects of the benzodiazepines on memory function.
Barbee
J G
JG
Department of Psychiatry, Louisiana State University School of Medicine, New Orleans 70112.
Black
F W
FW
Todorov
A A
AA
D000293:Adolescent; D000328:Adult; D000525:Alprazolam / Q000494:pharmacology*; D001143:Arousal / Q000187:drug effects*; D002065:Buspirone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D011939:Mental Recall / Q000187:drug effects*; D010153:Paired-Associate Learning; D012153:Retention, Psychology / Q000187:drug effects*
D002065:Buspirone; D000525:Alprazolam