[An in-vivo and in-vitro study of phagocyte migration in patients with AIDS].
Polymorphonuclear leukocytes (PMN), are considered the first line of host defense. The PMN defects were related with an increase susceptibility to infections. We studied the neutrophil chemotactic function in 20 patients suffering from AIDS. The results of in vivo study demonstrated the decrease of chemotactic activity at 6 hour (p < 0.001) in the patients respect to control. The data of in vitro studies confirmed the granulocyte chemotactic defects, statistically significant, in the patients compared to the control subjects, when we used all chemotactic factors. These results showing the profound immune disturbances characteristic of the disease can favour infective susceptibility and complicate follow-up of AIDS.
Pasotti
D
D
Istituto Superiore di Sanità, Roma.
Mazzone
A
A
Ricevuti
G
G
D017088:AIDS-Related Opportunistic Infections / Q000276:immunology; D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000328:Adult; D000368:Aged; D002634:Chemotaxis, Leukocyte; D015497:HIV-1; D006801:Humans; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology; D010586:Phagocytes / Q000276:immunology*; D012884:Skin Window Technique; D013997:Time Factors
Studio della migrazione in vivo ed in vitro dei fagociti in pazienti affetti da AIDS.