High synovial immunoglobulin E levels in eosinophilic synovitis.
Eosinophilic synovitis occurred in a 7-year-old boy. Synovial fluid leukocytes were mostly eosinophils; the peripheral blood showed only mild eosinophilia. The level of eosinophil-derived neurotoxin in the synovial fluid was higher than that in the serum, suggesting intraarticular eosinophil degranulation. The IgE level was also elevated in the synovial fluid (3854 ng/ml) but normal in the serum (408 ng/ml), suggesting a localized immediate hypersensitivity immune response.
Padeh
S
S
Department of Pediatrics and Surgery, Hospital for Sick Children, Toronto, Ontario, Canada.
Laxer
R M
RM
Gleich
G J
GJ
Armstrong
P F
PF
Silverman
E D
ED
D002648:Child; D047208:Eosinophil-Derived Neurotoxin; D004802:Eosinophilia / Q000276:immunology*; D004804:Eosinophils / Q000378:metabolism / Q000502:physiology; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis* / Q000097:blood; D008297:Male; D009498:Neurotoxins / Q000032:analysis; D012260:Ribonucleases; D013582:Synovial Fluid / Q000737:chemistry / Q000276:immunology*; D013585:Synovitis / Q000097:blood / Q000276:immunology*
D009498:Neurotoxins; D007073:Immunoglobulin E; D047208:Eosinophil-Derived Neurotoxin; D012260:Ribonucleases