title: Inhibitory effect of human chorionic gonadotropin (hCG) on HIV-1 transmission from lymphocytes to trophoblasts.
abstract: It has been demonstrated that human chorionic gonadotropin (hCG) inhibits HIV production in vitro, suggesting that this soluble placental glycoprotein can control viral replication and spread in vivo. hCG--the major product of fetal trophoblasts--was tested on an in vitro model consisting of choriocarcinoma-derived ENAMI trophoblasts exposed to HIV-infected MOLT-4 lymphocytes. The results show a U-shaped antiviral dose-effect and suggest that hCG may contribute to protection against intrauterine transmission of HIV-1.
authors.affiliation: Population Council, Center for Biomedical Research, New York, NY 10021.
authors.forename: A S
authors.initials: AS
authors.lastname: Bourinbaiar
authors.forename: R
authors.initials: R
authors.lastname: Nagorny
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D004797:Enzyme-Linked Immunosorbent Assay; D016655:HIV Core Protein p24 / Q000032:analysis; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008214:Lymphocytes / Q000382:microbiology*; D014327:Trophoblasts / Q000382:microbiology*; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D006063:Chorionic Gonadotropin; D016655:HIV Core Protein p24