A novel note on the effect of ara-C on the polyamine content of the male accessory organs of the rat.
The effects of 1-beta-D-arabinosylcytosine (ara-C) given for 5 days on body weight, on the weights of the prostate, seminal vesicles and testis, and on the polyamine content (putrescine, put; spermidine, spd; spermine, spm) in these organs were examined in rats. The body weights of the ara-C-treated rats showed a decrease of 13% (P less than 0.01) and the weights of the prostate, seminal vesicles and testis were reduced by 20% (P less than 0.05), 13% and 5.0% (P less than 0.1), respectively. However, put, spd and spm contents in the ara-C-treated prostate were increased 1.2, 1.8 and 2.9 times, respectively. The contents of these polyamines in the ara-C-treated seminal vesicles increased about 40% for all polyamines. Both spd and spm in the treated testis showed a significant increase of about 20% (P less than 0.05) as compared with the control. In addition, the total polyamines in the whole organs increased significantly in both the prostate and testis.
Watanabe
S
S
Department of Pharmacology, Kawasaki Medical School, Okayama, Japan.
Sato
S
S
Nagase
S
S
Saito
T
T
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003561:Cytarabine / Q000494:pharmacology*; D005837:Genitalia, Male / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011073:Polyamines / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
D011073:Polyamines; D003561:Cytarabine