[Relationship between chemical structure and toxicologic-pharmacokinetic properties of new ampicillin derivatives].
The toxicity and the bioavailability of new ampicillin derivatives with glyoxylic acid benzhydrazones as site chain depend on the hydrophobic properties of the site chain. Substituents with lower hydrophobicity (expressed by the hydrophobic substituent constant pi according to Hansch) show a lower toxicity (maximal tolerated doses) and also a lower bioavailability.
Willitzer
H
H
Institut für Mikrobiologie und experimentelle Therapie (ZIMET), Jena.
Horn
U
U
Heinisch
L
L
Möllmann
U
U
Hanschke
K G
KG
Stengel
K
K
Eckardt
K
K
D000667:Ampicillin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics* / Q000633:toxicity; D000818:Animals; D001682:Biological Availability; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains
D000667:Ampicillin
Beziehungen zwischen chemischer Struktur und toxikologisch-pharmakokinetischen Eigenschaften neuer Ampicillin-Derivate.