title: Antiinflammatory and antipyretic activity of vicolides of Vicoa indica DC.
abstract: Vicolides A,B, C and D, the sesquiterpene lactones isolated from V. indica exhibited antiinflammatory activity against cotton pellet granuloma in rats at dose level of 10 mg/kg body weight, sc. Highly significant activity was observed with vicolides C and D. They reduced the protein content, acid and alkaline phosphatase, glutamate-pyruvate transaminase and glutamate oxaloacetate transaminase activities in liver and serum. Significant reduction in ascorbic acid content in adrenals was also observed in treated animals. The highly significant antiinflammatory activity of vicolides C and D can be attributed to their chemical structures. Vicolide D has an epoxy angeloyl group while vicolide C has 3,4 epoxy group and an ester moiety in the molecule. Vicolide D possesses antipyretic activity at 250 mg/kg body weight, po dose. It may be due to the presence of epoxy angeloyl group in the molecule.
authors.affiliation: Captain Srinivasa Murti Drug Research Institute for Ayurveda, Madras, India.
authors.forename: M
authors.initials: M
authors.lastname: Alam
authors.forename: T
authors.initials: T
authors.lastname: Susan
authors.forename: S
authors.initials: S
authors.lastname: Joy
authors.forename: A B
authors.initials: AB
authors.lastname: Kundu
mesh_terms: D000311:Adrenal Glands / Q000033:anatomy & histology / Q000378:metabolism; D000818:Animals; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000096:biosynthesis; D004798:Enzymes / Q000097:blood; D006099:Granuloma / Q000188:drug therapy*; D007783:Lactones / Q000494:pharmacology* / Q000627:therapeutic use; D008099:Liver / Q000201:enzymology; D008107:Liver Diseases / Q000188:drug therapy; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D012717:Sesquiterpenes / Q000494:pharmacology* / Q000627:therapeutic use; D013154:Spleen / Q000033:anatomy & histology; D013950:Thymus Gland / Q000033:anatomy & histology
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004798:Enzymes; D007783:Lactones; D012717:Sesquiterpenes; D001205:Ascorbic Acid