Asymmetry of salivary gland I123 metaiodobenzylguanidine (MIBG) uptake in a patient with cervical neuroblastoma and Horner's syndrome--possible etiologic mechanisms.
Horner's syndrome may be due to a variety of serious underlying disorders including cervical neuroblastoma. Horner's syndrome results from a unilateral disruption of the sympathetic innervation to the head and neck. We report a patient with cervical neuroblastoma in whom post operative metaiodobenzylguanidine (MIBG) scans showed a striking decrease in uptake in the ipsilateral salivary glands. Since the bio-distribution of I123 metaiodobenzylguanidine in the salivary glands in also dependent on sympathetic innervation, the presence of Horner's syndrome can be reflected in the MIBG scan.
Sandler
E D
ED
Department of Pathology and Nuclear Medicine, St. Mary's Hospital, San Francisco, California.
Hattner
R S
RS
Parisi
M T
MT
D019797:3-Iodobenzylguanidine; D005260:Female; D006258:Head and Neck Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D006732:Horner Syndrome / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007457:Iodine Radioisotopes; D007462:Iodobenzenes / Q000493:pharmacokinetics; D008297:Male; D009447:Neuroblastoma / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D012469:Salivary Glands / Q000294:innervation / Q000378:metabolism
D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine