[A model of diabetes mellitus in dogs: combination of pancreas resection with intra-arterial administration of alloxan].
A study was made of the indices of blood sugar on an empty stomach, GTT, blood insulin, body mass and the general status in 17 mongrels during one month after various types of resection of the pancreas: the 1st group--resection (80%), the 2nd group--resection (68%), the 3rd group--resection combined with intraarterial administration of alloxan. Insulin was determined using a standard kit RIO-INS-PG-125I by a radioimmunoassay. Alloxan was injected during operation at a dose of 250 mg (5% solution) in the upper pancreatoduodenal artery. Stable hyperglycemia, diabetogenic disturbances in GTT, a decrease in the blood level of insulin, and a clinical picture of diabetes mellitus were observed after operation in the 1st and 3rd groups. A new model of experimental diabetes mellitus in dogs (a combination of pancreas resection with intraarterial administration of alloxan) was recommended.
Agaev
B A
BA
Velikhanova
D M
DM
Gadzhiev
A N
AN
D000496:Alloxan / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000209:etiology*; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D005951:Glucose Tolerance Test; D007269:Injections, Intra-Arterial; D007328:Insulin / Q000097:blood; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000502:physiology / Q000601:surgery*; D011863:Radioimmunoassay
D001786:Blood Glucose; D007328:Insulin; D000496:Alloxan
Model' sakharnogo diabeta u sobak: kombinatsiia rezektsii podzheludochnoĭ zhelezy s vnutriarterial'nym vvedeniem alloksana.