title: Effects of growth hormones on bone formation and resorption in rainbow trout (Oncorhynchus mykiss), as examined by histomorphometry of the pharyngeal bone.
abstract: Effects of salmon and eel growth hormones (GHs) on bone metabolism in rainbow trout (Oncorhynchus mykiss) were studied using histomorphometry of their pharyngeal bones. When salmon GH (sGH) was injected intraperitoneally at a dose of 0.01 or 0.1 microgram/g/week for 10 times into fed trout, body growth in both length and weight was accelerated. Formation and resorption of bone were enhanced only by the higher dose of sGH. When a cholesterol pellet containing recombinant eel GH (reGH-pellet) was implanted subcutaneously into starved trout for 1 week (37 micrograms reGH/18 g fish), formation and resorption of bone increased, although activity of bone formation was low. The results indicate that the GHs increased both formation and resorption of bone, regardless of the nutritional status of the fish.
authors.affiliation: Faculty of Fisheries, Hokkaido University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takagi
authors.forename: S
authors.initials: S
authors.lastname: Moriyama
authors.forename: T
authors.initials: T
authors.lastname: Hirano
authors.forename: J
authors.initials: J
authors.lastname: Yamada
mesh_terms: D000818:Animals; D001846:Bone Development / Q000187:drug effects*; D001862:Bone Resorption; D001842:Bone and Bones / Q000033:anatomy & histology* / Q000187:drug effects; D002118:Calcium / Q000097:blood; D004524:Eels; D013006:Growth Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology; D012474:Salmon; D012964:Sodium / Q000097:blood; D014337:Trout / Q000033:anatomy & histology / Q000502:physiology*
chemical_list: D011994:Recombinant Proteins; D013006:Growth Hormone; D012964:Sodium; D002118:Calcium