title: Evaluation of tissue polypeptide antigen serum levels for monitoring disease activity during chemotherapy in patients with transitional carcinoma of the urinary tract.
abstract: In 28 patients with transitional carcinoma of the urinary tract, all treated with chemotherapy, serial measurements of serum tissue polypeptide antigen (TPA) were performed and correlated to clinical evaluations of response. At the start of chemotherapy elevated levels of TPA were found in 4 out of 14 patients with T2-4NO-2MO tumours and in 7 out of 14 patients with distant metastases. In most patients with elevated TPA levels who responded to chemotherapy, TPA levels rapidly returned to normal. False positive elevations of TPA were observed in 2 patients. It is concluded that serial measurement of TPA for monitoring disease activity has limited value because of the low sensitivity of TPA, especially for patients with early-stage cancer, and because of the occurrence of false positive results.
authors.affiliation: Department of Medical Oncology, University Hospital Rotterdam-Dijkzigt, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: van der Gaast
authors.forename: W J
authors.initials: WJ
authors.lastname: Kirkels
authors.forename: B G
authors.initials: BG
authors.lastname: Blijenberg
authors.forename: T A
authors.initials: TA
authors.lastname: Splinter
mesh_terms: D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D016190:Carboplatin / Q000627:therapeutic use; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D002945:Cisplatin / Q000627:therapeutic use; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007118:Immunoassay / Q000379:methods; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D010455:Peptides / Q000097:blood*; D011237:Predictive Value of Tests; D019396:Tissue Polypeptide Antigen; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D009944:Organoplatinum Compounds; D010455:Peptides; D019396:Tissue Polypeptide Antigen; C023359:iproplatin; D016190:Carboplatin; D002945:Cisplatin; D008727:Methotrexate