The development of neuropeptide Y immunoreactive neurons in cat visual cortical areas.
The development of NPY-ir neurons and fibers in cat striate and extrastriate cortex was studied to determine whether temporal changes in the morphology, distribution and density of NPY-ir neurons during development would provide clues to the emergence of specific cortical areas. No differences in the number or distribution of NPY-ir neurons were observed at any age among the five visual cortical areas examined, area 17, 18, 19, posteromedial lateral suprasylvian and posterolateral lateral suprasylvian cortex. The number of NPY-ir neurons in cat visual cortical areas was higher in adult animals than in kittens. The proportion of NPY-ir neurons found in layer VIb was constant throughout life, suggesting that NPY immunoreactivity is not a marker for the transient neurons of the subplate. NPY-ir neuronal morphology was seen to 'flatten' in older animals with the development of sulci and increasing density of the brain. In contrast to the pattern observed with NPY-ir neurons, NPY-ir processes exhibited area-dependent differences during development. NPY-ir fibers grew into area 17 earlier and with a radial orientation which was not consistently observed laterally. This radial orientation was still apparent in adult brains in layer IV of area 17, though there was no orientation of fibers in the other laminae or other visual areas of the adult.
Hogan
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University of Kansas Medical Center, Department of Anatomy and Cell Biology, Kansas City 66160-7400.
Berman
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NE
D000375:Aging / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn; D002415:Cats; D007150:Immunohistochemistry; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D009478:Neuropeptide Y / Q000032:analysis / Q000378:metabolism; D014793:Visual Cortex / Q000033:anatomy & histology / Q000166:cytology / Q000254:growth & development*
D009478:Neuropeptide Y