Innervation of pylorus in control of motility and gastric emptying.
The motility index (MI) and contractile frequency were determined for the gastric antrum, pylorus, and duodenum during digestive and interdigestive states in eight dogs before and after resection of the ramus pyloricus nervi vagi (NR) and after selective proximal vagotomy (SPV) subsequent to NR. Neither NR nor subsequent SPV altered the migrating motor complex in the interdigestive state. In the digestive state, NR decreased the MI in the antrum, pylorus, and duodenum. The MI did not further change after SPV subsequent to NR. The cholecystokinin antagonist L364,718 decreased MI in the antrum, pylorus, and duodenum. After NR, L364,718 caused a further reduction in the MI during administration. Gastric emptying was accelerated after NR. SPV subsequent to NR increased gastric emptying further. L364,718, in the absence of NR, accelerated gastric emptying but only during the initial period of emptying. After NR, L364,718 also decreased the time required for emptying of 50 and 100% of the meal. After SPV subsequent to NR, no additional acceleration of emptying occurred.
Holle
G E
GE
Walther Straub Institute for Pharmacology and Toxicology, Ludwig Maximilian University, Munich, Federal Republic of Germany.
Hahn
D
D
Forth
W
W
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology; D002766:Cholecystokinin / Q000037:antagonists & inhibitors; D020109:Devazepide; D004285:Dogs; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects / Q000502:physiology*; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000502:physiology*; D008297:Male; D016065:Myoelectric Complex, Migrating / Q000502:physiology; D009424:Nervous System Physiological Phenomena; D011708:Pylorus / Q000000981:diagnostic imaging / Q000294:innervation*; D011859:Radiography; D014628:Vagotomy
D001570:Benzodiazepinones; D002766:Cholecystokinin; D020109:Devazepide