Direct high-performance liquid chromatographic separation of enantiomeric peptidoleukotriene antagonists.
Enantiomeric peptidoleukotriene antagonists, SK&F R-106203 and SK&F S-106203 can be effectively separated on a cellulose tris(3,5-dimethylphenylcarbamate) chiral stationary phase. The utility of this chiral high-performance liquid chromatographic method in assigning absolute stereochemistry to SK&F S-106203-Z2, a non-crystalline amorphous compound which is not amenable to single crystal X-ray analysis, is demonstrated by correlation with the absolute configuration determined crystallographically for a second salt form.
Chen
T K
TK
Department of Analytical Chemistry, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406-0939.
Erhard
K F
KF
Last
T
T
Eggleston
D S
DS
Ho
M Y
MY
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003998:Dicarboxylic Acids / Q000737:chemistry / Q000302:isolation & purification*; D020024:Leukotriene Antagonists; D008968:Molecular Conformation; D013237:Stereoisomerism; D014961:X-Ray Diffraction
D003998:Dicarboxylic Acids; D020024:Leukotriene Antagonists; C065234:SK&F S-106203