title: Duodenal acidification and intra-arterial injection of CCK8 increase gallbladder motility in the rainbow trout, Oncorhynchus mykiss.
abstract: A sensitive method for in vivo measurement of intra-gallbladder pressure in free swimming rainbow trout (Oncorhynchus mykiss) is described. The method gives information on changes in gallbladder pressure after either instillation of liquids into the duodenum or infusion/injection of agents into the circulatory system. Blood samples can also be taken. Duodenal acidification is a potent initiating factor for gallbladder motility in the rainbow trout. Intra-arterially injected sulfated octapeptide of cholecystokinin is also a potent excitatory agent for activating the gallbladder. Acidification of the upper intestine causes release of cholecystokinin, which affects gallbladder motility in trout as in mammals.
authors.affiliation: Department of Zoophysiology, University of Göteborg, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Aldman
authors.forename: D
authors.initials: D
authors.lastname: Grove
authors.forename: S
authors.initials: S
authors.lastname: Holmgren
mesh_terms: D000818:Animals; D001652:Bile Ducts / Q000502:physiology / Q000601:surgery; D004386:Duodenum / Q000502:physiology*; D005704:Gallbladder / Q000187:drug effects / Q000502:physiology*; D006863:Hydrogen-Ion Concentration; D007269:Injections, Intra-Arterial; D008026:Ligation; D011312:Pressure; D012844:Sincalide / Q000008:administration & dosage / Q000494:pharmacology*; D014337:Trout / Q000502:physiology*
chemical_list: D012844:Sincalide