title: Bone formation near direct current electrodes with and without motion.
abstract: The osteogenesis induced in the medullary canal of rabbits by the implantation of moving and stationary wire electrodes was studied with and without the simultaneous application of 20-microA constant direct cathodic current. After 3 weeks, the formation of new trabecular bone in the canal was studied and measured microscopically. Electrically stimulated osteogenesis was not observed at stationary electrodes. As in previous studies with this model, a movable electrode alone stimulated new bone formation whose area was 7-10% of the canal area. The amount of this bone was not statistically increased by the addition of cathode current. Movable, electrically active cathodes were associated, however, with fluid-filled spaces incorporated within the new trabecular bone. When mechanical stimuli were controlled, we were not able to demonstrate that the direct current stainless steel cathode acts either as an inducer or a substantial enhancer of medullary osteogenesis.
authors.affiliation: Department of Orthopedic Surgery, State University of New York, Syracuse 13210.
authors.forename: J A
authors.initials: JA
authors.lastname: Spadaro
authors.forename: S A
authors.initials: SA
authors.lastname: Albanese
authors.forename: S E
authors.initials: SE
authors.lastname: Chase
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001846:Bone Development / Q000502:physiology; D004553:Electric Conductivity; D004558:Electric Stimulation; D004566:Electrodes; D005269:Femur / Q000166:cytology / Q000502:physiology; D008954:Models, Biological; D010012:Osteogenesis / Q000502:physiology*; D011817:Rabbits