title: Effects of flurbiprofen and suprofen on the miotic activity of 1% acetylcholine and 0.01% carbachol.
abstract: The nonsteroidal antiinflammatory agents (NSAIAs) flurbiprofen and suprofen applied topically to reduce miosis may counteract the desired effects of miotics used during ocular surgery. In a pigmented rabbit model, 1% acetylcholine was shown to cause a greater, significant initial (for the first 30 minutes) constriction (P less than .05) than 0.01% carbachol in eyes pretreated with flurbiprofen and suprofen. From 2 to 8 hours, NSAIA pretreatment had a greater miotic effect with carbachol than with acetylcholine. There were no significant differences between flurbiprofen and suprofen on the miotic effect of carbachol or acetylcholine.
authors.affiliation: Department of Ophthalmology, University of Texas Health Science Center, San Antonio 78284-6230.
authors.forename: R W
authors.initials: RW
authors.lastname: Yee
authors.forename: D
authors.initials: D
authors.lastname: Kocurek
authors.forename: H S
authors.initials: HS
authors.lastname: Yu
authors.forename: G
authors.initials: G
authors.lastname: Smith
authors.forename: C
authors.initials: C
authors.lastname: Lam
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D005480:Flurbiprofen / Q000494:pharmacology*; D011292:Premedication; D011680:Pupil / Q000187:drug effects*; D011817:Rabbits; D013496:Suprofen / Q000494:pharmacology*
chemical_list: D005480:Flurbiprofen; D002217:Carbachol; D013496:Suprofen; D000109:Acetylcholine