[The dynamics of the indices of protein metabolic homeostasis and the status of duodenal mucosal regeneration during the etaden treatment of duodenal peptic ulcer].
The authors relate the results of examining 149 men suffering from duodenal ulcer. The main group was made up of 75 patients given parenteral etaden treatment combined with conventional therapy. A study was made of the dynamics of clinical manifestations, the level of total protein and its fraction in the blood, protein metabolism (by radionuclide technique). Pieces of the duodenal mucosa from the periulcerous area were examined under microscope. Scanning and electron microscopy was also performed. Based on the data obtained it is concluded that etaden had active influence on protein synthesis, which favoured more rapid regression of the ulcerous defect in the main group patients. Morphological studies have also shown the positive dynamics of the regenerative process.
Korepanov
A M
AM
Murashov
V S
VS
Bazhenov
E L
EL
D000225:Adenine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D004341:Drug Evaluation; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000503:physiopathology; D004386:Duodenum / Q000187:drug effects* / Q000503:physiopathology; D006706:Homeostasis / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011506:Proteins / Q000187:drug effects* / Q000378:metabolism; D012038:Regeneration / Q000187:drug effects* / Q000502:physiology; D013268:Stimulation, Chemical
D000897:Anti-Ulcer Agents; D011506:Proteins; C014531:etaden; D000225:Adenine
Dinamika nekotorykh pokazateleĭ belkovo-metabolicheskogo gomeostaza i sostoianie regeneratsii duodenal'noĭ slizistoĭ v protsesse lecheniia iazvnenoĭ bolezni dvenadtsatiperstnoĭ kishki étadenom.