Idiopathic childhood stroke is associated with human leukocyte antigen (HLA)-B51.
We report four children with idiopathic stroke syndromes who were assayed for human leukocyte antigen (HLA) class I markers and found to have HLA-B51 in common. This finding suggests that there may be a genetic predisposition for "idiopathic" childhood stroke, and host factors, possibly in concert with environmental factors or viruses, may play a major role in the mechanism of unexplained occlusion of the cerebral vasculature in children.
Mintz
M
M
Department of Neurosciences, University of Medicine and Dentistry-New Jersey Medical School, Newark 07103.
Epstein
L G
LG
Koenigsberger
M R
MR
D002561:Cerebrovascular Disorders / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D005805:Genes, MHC Class I; D020022:Genetic Predisposition to Disease; D015235:HLA-B Antigens / Q000032:analysis*; D059949:HLA-B51 Antigen; D006630:Hispanic or Latino / Q000235:genetics; D006801:Humans; D007223:Infant; D008297:Male; D014652:Vascular Diseases / Q000235:genetics
D015235:HLA-B Antigens; D059949:HLA-B51 Antigen