[Clinical analysis of Vogt-Koyanagi-Harada's disease and its association with HLA].
Clinical analysis of 34 patients with Vogt-Koyanagi-Harada's disease in Hunan Province showed that most patients had good visual prognosis following intensive corticosteroid therapy. A multivariate stepwise regression analysis indicated that visual acuity at the first visit, elapse of time before treatment began, duration of papilledema, and presence of ocular complications were significant factors for eventual visual acuity. HLA typing on 25 patients and 65 normal controls suggested that HLA-DR4 and DRW53 might be an immunogenetic background for the high incidence of the disease in oriental populations.
Zhao
M
M
Department of Ophthalmology, Second Affiliated Hospital, Hunan Medical University Changsha.
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006684:HLA-DR Antigens / Q000032:analysis*; D015804:HLA-DR4 Antigen / Q000032:analysis*; D059845:HLA-DRB4 Chains; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012044:Regression Analysis; D014607:Uveomeningoencephalitic Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D014792:Visual Acuity
D000305:Adrenal Cortex Hormones; D006684:HLA-DR Antigens; D015804:HLA-DR4 Antigen; C050610:HLA-DR53; D059845:HLA-DRB4 Chains