title: Age-associated decreases in prostaglandin contents in human gastric mucosa.
abstract: This study was designed to clarify effects of ageing on human gastric mucosal prostaglandin (PG) contents. Forty examinees were divided into 5 age groups of 8 persons each, as follows: age under 40, age 40-49, age 50-59, age 60-69, and age over 70. PG contents in human gastric mucosa were measured by microcolumn high performance liquid chromatography (HPLC) with helium/cadmium laser induced fluorescence detection using biopsy samples obtained by endoscopy. The contents of 6-keto-PGF1 alpha, PGF2 alpha, PGE2, and PGD2 in the under 40 group were 638 +/- 39, 97 +/- 16, 468 +/- 68, 497 +/- 86 (pg/mg tissue), respectively. No significant differences in PG contents among groups aged under 70 were observed. In contrast, significantly low PG contents in the over 70 group were observed, i.e., the contents of 6-keto-PGF1 alpha, PGF2 alpha, PGE2, and PGD2 were 311 +/- 58, 36 +/- 8, 196 +/- 48, 171 +/- 40, respectively, and their contents were significantly lower than those in other age groups. In conclusion, gastric mucosal PG contents decrease significantly in over 70 years-old and this might be a contributing factor in the pathogenesis of gastric ulcers in elderly people.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, University of Nagoya, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Goto
authors.forename: S
authors.initials: S
authors.lastname: Sugiyama
authors.forename: A
authors.initials: A
authors.lastname: Ohara
authors.forename: H
authors.initials: H
authors.lastname: Hoshino
authors.forename: E
authors.initials: E
authors.lastname: Hamajima
authors.forename: S
authors.initials: S
authors.lastname: Kanamori
authors.forename: Y
authors.initials: Y
authors.lastname: Tsukamoto
authors.forename: T
authors.initials: T
authors.lastname: Ozawa
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000032:analysis; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D002851:Chromatography, High Pressure Liquid; D015237:Dinoprost / Q000032:analysis; D015232:Dinoprostone / Q000032:analysis; D005753:Gastric Mucosa / Q000254:growth & development* / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D015230:Prostaglandin D2 / Q000032:analysis; D011453:Prostaglandins / Q000032:analysis*
chemical_list: D011453:Prostaglandins; D015121:6-Ketoprostaglandin F1 alpha; D015237:Dinoprost; D015232:Dinoprostone; D015230:Prostaglandin D2