Determination of reference intervals in the clinical laboratory using the proposed guideline National Committee for Clinical Laboratory Standards C28-P.
The Subcommittee on Reference Intervals of the National Committee for Clinical Laboratory Standards (NCCLS) has recently completed a proposed guideline, NCCLS Document C28-P, entitled "How to Define, Determine, and Utilize Reference Intervals in the Clinical Laboratory." This guideline document is an attempt to combine a concise set of procedures and recommendations, largely taken from the original literature, to form a standard, uniform, and reasonable protocol for determining population-based reference intervals. The intent of the guideline is to set forth the minimum requirements for the determination of a reliable and clinically useful reference interval. The subcommittee hopes the document will set a standard that upgrades the quality of reference intervals to a level worthy of their use in clinical medicine.
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Department of Pathology, Medical College of Wisconsin, Milwaukee County General Hospital 53226.
D005260:Female; D006287:Health Planning Guidelines; D006801:Humans; D007753:Laboratories / Q000592:standards*; D008297:Male; D010338:Pathology, Clinical / Q000592:standards*; D012016:Reference Values; D014481:United States