title: Phase II study of amonafide in advanced and recurrent sarcoma patients.
abstract: The activity of amonafide, a benzisoquinoline-1,3-dione, was assessed in 15 patients with advanced or recurrent sarcoma (11 previously treated). Eligible patients had ECOG performance status 0-2, and acceptable renal, hepatic and bone marrow function. Amonafide 300 mg/m2 was given intravenously over one hour daily on five consecutive days, every 3 weeks. Leukopenia and granulocytopenia were the most common and severe toxicities (grade 3 or 4 toxicity in 20% and 27% of patients, respectively). Local irritation and nausea/vomiting, the most common nonhematologic toxicities, were generally mild. No objective responses were seen, though 2 patients had brief stabilization of disease. Amonafide at this dose and schedule has no activity against advanced, recurrent sarcoma.
authors.affiliation: Dept. of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111.
authors.forename: R P
authors.initials: RP
authors.lastname: Perez
authors.forename: S L
authors.initials: SL
authors.lastname: Nash
authors.forename: R F
authors.initials: RF
authors.lastname: Ozols
authors.forename: R L
authors.initials: RL
authors.lastname: Comis
authors.forename: P J
authors.initials: PJ
authors.lastname: O'Dwyer
mesh_terms: D000225:Adenine; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007094:Imides; D007275:Injections, Intravenous; D007546:Isoquinolines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D053644:Naphthalimides; D063065:Organophosphonates; D012008:Recurrence; D012509:Sarcoma / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D007094:Imides; D007546:Isoquinolines; D053644:Naphthalimides; D063065:Organophosphonates; C037020:amonafide; D000225:Adenine