title: A case of linitis plastica of the rectum treated by pelvic exenteration after aggressive immunochemotherapy.
abstract: Multidisciplinary treatment was administered to a 32 year-old man with primary linitis plastica of the rectum, which was considered inoperable due to an extensive local spread at the first operation. Thirty KE of OK-432 was injected into the tumor per week (total 90-KE) and 5 KE of OK-432 was inoculated into the intracutaneous space per week (total 125 KE). Also methotrexete (MTX 50 mg) and 5-FU (500 mg) combined were given each week by intra-arterial infusion (total 20 courses). After this immuno-chemotherapy the CEA decreased from the pretreatment value of 12.7 ng/ml to 3.6 ng/ml and the tumor size was reduced. A total pelvic exenteration could then be performed almost curatively. As a result, this patient was able to return to the society with a better quality of life and has survived for 20 months since presentation.
authors.affiliation: Department of Surgery, Karatsu Red Cross Hospital, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Sato
authors.forename: K
authors.initials: K
authors.lastname: Iwasaki
authors.forename: M
authors.initials: M
authors.lastname: Torisu
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007261:Infusions, Intra-Arterial; D007271:Injections, Intradermal; D015552:Injections, Intralesional; D008039:Linitis Plastica / Q000628:therapy*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use*; D010385:Pelvic Exenteration; D010844:Picibanil / Q000008:administration & dosage / Q000627:therapeutic use*; D012004:Rectal Neoplasms / Q000628:therapy*
chemical_list: D010844:Picibanil; D005472:Fluorouracil; D008727:Methotrexate