Safety and immunogenicity of a booster dose of Vibrio cholerae CVD 103-HgR live oral cholera vaccine in Swiss adults.
Adult volunteers received a booster dose (4 x 10(8) CFU) of attenuated Vibrio cholerae CVD 103-HgR oral vaccine 15 or 24 months after primary immunization. The immune response was modest, presumably due to rapid clearance of the vaccine strain by a primed immune system.
Cryz
S J
SJ
Swiss Serum and Vaccine Institute, CH-3001 Berne.
Levine
M M
MM
Losonsky
G
G
Kaper
J B
JB
Althaus
B
B
D000284:Administration, Oral; D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis; D022121:Cholera Vaccines / Q000276:immunology* / Q000633:toxicity; D006801:Humans; D007117:Immunization, Secondary; D008875:Middle Aged; D014613:Vaccines, Attenuated / Q000276:immunology
D000907:Antibodies, Bacterial; D022121:Cholera Vaccines; D014613:Vaccines, Attenuated