[Fundamental study on levofloxacin in the field of obstetrics and gynecology].
We performed a fundamental study on levofloxacin (LVFX, DR-3355), a new synthetic antimicrobial agent, in the field of obstetrics and gynecology. Concentrations in serum and intrapelvic genital organs (various regions in the uterus, ovary and oviduct) were determined following single oral administration. The transport of LVFX into genital tissues was found to be good, with the tissue levels of 0.64-2.13 micrograms/g after oral administration of 100 mg and 0.77-4.86 micrograms/g after administration of 200 mg. These tissue levels of LVFX were higher than those in serum and exceeded the MIC90 values against most causative organisms isolated from the lesions of obstetric and gynecological infections. These data indicate that LVFX should be useful in the field of obstetrics and gynecology.
Soyama
Y
Y
Department of Obstetrics and Gynecology, Kawasaki Municipal Hospital.
Mizuhara
H
H
Iwata
Y
Y
D000284:Administration, Oral; D000328:Adult; D005260:Female; D006801:Humans; D064704:Levofloxacin; D008875:Middle Aged; D015242:Ofloxacin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D010053:Ovary / Q000378:metabolism*; D014599:Uterus / Q000378:metabolism*
D064704:Levofloxacin; D015242:Ofloxacin