Total and lipid-bound serum sialic acid as markers for carcinoma of the uterine cervix.
Concentrations of total sialic acid (TSA) and lipid-bound sialic acid (LSA) were determined in serum samples from 88 patients with squamous cell carcinoma of the cervix, 26 normal subjects, and 44 patients with benign uterine or ovarian disease. TSA concentrations in patients with cervical cancer were found to correlate with advanced-stage disease. LSA concentrations were only increased in stage IV of the disease. Sensitivity of the test for stage IB was zero for TSA and 27% for LSA. The specificity of both markers was about 80% due to a low incidence of false-positive values in the pathologic control group. Measurements of TSA or LSA appear to be of no value for the early detection of cervical cancer or to complement the clinical staging of this tumor.
Vivas
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Instituto de Medicina Experimental, Universidad Central de Venezuela, Sabana Grande, Caracas.
Spagnuolo
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Palacios
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D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006017:Glycolipids / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D019158:N-Acetylneuraminic Acid; D009367:Neoplasm Staging; D012680:Sensitivity and Specificity; D012794:Sialic Acids / Q000097:blood*; D012795:Sialoglycoproteins / Q000097:blood*; D014594:Uterine Neoplasms / Q000097:blood / Q000175:diagnosis*
D014408:Biomarkers, Tumor; D006017:Glycolipids; D012794:Sialic Acids; D012795:Sialoglycoproteins; C009255:sialoglycolipids; D019158:N-Acetylneuraminic Acid