Human immunodeficiency virus infection in central nervous system and myeloid-monocytic lineage.
We established persistent infection with a strain of human immunodeficiency type 1, HTLV-IIIB, in a ++promyelo-monocytic cell line, ML-1 (CD4 antigen nearly negative and CD4 mRNA negative), and a promonocytic cell line, THP-1 (CD4 antigen positive). Different reactions of giant cell formation were found after cocultivation of infected and uninfected cells of ML-1, HL-60, THP-1 and U-937 cell lines with uninfected and infected MOLT4 (a T-lymphoma cell line). Factors affecting the cellular tropism of human immunodeficiency virus were discussed.
Ushijima
H
H
Department of Enteroviruses, National Institute of Health, Tokyo, Japan.
Abe
T
T
D015526:AIDS Dementia Complex / Q000097:blood / Q000276:immunology / Q000473:pathology*; D001921:Brain / Q000276:immunology / Q000473:pathology*; D015704:CD4 Antigens / Q000032:analysis / Q000276:immunology; D002460:Cell Line; D002462:Cell Membrane / Q000276:immunology / Q000382:microbiology / Q000648:ultrastructure; D004660:Encephalitis / Q000097:blood / Q000276:immunology / Q000473:pathology*; D006098:Granulocytes / Q000276:immunology / Q000382:microbiology / Q000473:pathology / Q000648:ultrastructure; D006678:HIV / Q000276:immunology / Q000302:isolation & purification; D015658:HIV Infections / Q000097:blood / Q000276:immunology / Q000473:pathology*; D015497:HIV-1 / Q000276:immunology / Q000302:isolation & purification; D006412:Hematopoietic Stem Cells / Q000276:immunology / Q000382:microbiology / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D066298:In Vitro Techniques; D008854:Microscopy, Electron; D009000:Monocytes / Q000276:immunology / Q000382:microbiology / Q000473:pathology / Q000648:ultrastructure
D015704:CD4 Antigens