Enzyme-catalyzed oligosaccharide synthesis.
Cell-surface carbohydrates and their conjugates are involved in many types of molecular recognition. This review describes recent developments in enzyme-catalyzed oligosaccharide synthesis, with particular focus on glycosyltransferase and glycosidase reactions. With the increasing availability of glycosyltransferases via recombinant DNA technology, glycosyltransferase-catalyzed glycosylation with in situ regeneration of sugar nucleotides appears to be the most effective method for large-scale stereocontrolled oligosaccharide synthesis.
Ichikawa
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Department of Chemistry, Scripps Research Institute, La Jolla, California 92037.
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Wong
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D002240:Carbohydrate Sequence; D006026:Glycoside Hydrolases / Q000378:metabolism*; D016695:Glycosyltransferases / Q000378:metabolism*; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000096:biosynthesis*
D009844:Oligosaccharides; D016695:Glycosyltransferases; D006026:Glycoside Hydrolases