title: Selection of fat-equivalent materials in postprocessing dual-energy quantitative CT.
abstract: Postprocessing dual-energy QCT is supposed to be able to predict the bone mineral more accurately than single-energy QCT. In addition, the fat content in the vertebral body can be determined. To this aim, some methods include fat-equivalent materials in the calibration device. However, the choice of an appropriate fat-equivalent material is difficult. To solve this selection problem, a method has been developed in which the x-ray interactions of tissue are characterized by three energy-independent parameters. For five different known constituents of anatomical fat, fat-equivalent materials are evaluated. It is shown that it is not possible to find one fat-equivalent material for all anatomical fat compositions. For this reason, the influence of a mismatch between the characterization parameters of anatomical fat compositions and fat-equivalent materials has been evaluated. It is shown that a mismatch in tissue characterization parameters can result in deviations of 10% in the bone mineral content and more than 300% in the estimated fat contents.
authors.affiliation: Philips Medical Systems, Best, The Netherlands.
authors.forename: J C
authors.initials: JC
authors.lastname: Steenbeek
authors.forename: C
authors.initials: C
authors.lastname: van Kuijk
authors.forename: J L
authors.initials: JL
authors.lastname: Grashuis
authors.forename: R B
authors.initials: RB
authors.lastname: van Panthaleon van Eck
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging*; D015519:Bone Density; D006801:Humans; D013131:Spine / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000379:methods*