A study of the penetration of meropenem into bile using endoscopic retrograde cholangiography.
One gram of meropenem was administered as prophylaxis to patients undergoing endoscopic retrograde cholangiography (ERC) in a study of the bile pharmacokinetics of this agent. Twenty-four patients were evaluated and a single bile sample was collected from each one during ERC at different time intervals following intravenous infusion. Bile concentrations after the dose ranged from 0.7 to 25.7 mg/L (mean 11.1) and exceeded the MIC90s for the pathogens most commonly associated with biliary tract infections for up to 203 mins. The bile concentrations of 13 patients with biliary tree obstruction were compared with those of 11 patients without obstruction. Bile concentrations in excess of the MIC90s for the predominant pathogens were achieved in both groups; a positive correlation between meropenem bile concentration and the time of dose administration was demonstrable only for the obstructed group. ERC may be a useful technique for biliary pharmacokinetic studies.
Granai
F
F
Department of Medicine and Pharmacology, University of Sheffield, Royal Hallamshire Hospital, UK.
Smart
H L
HL
Triger
D R
DR
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000517:prevention & control; D001646:Bile / Q000378:metabolism*; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D000077731:Meropenem; D008875:Middle Aged; D013845:Thienamycins / Q000493:pharmacokinetics* / Q000627:therapeutic use
D013845:Thienamycins; D000077731:Meropenem