title: Acute pulmonary toxicity of inhaled beta-1,3-glucan and endotoxin.
abstract: The number of inflammatory cells was studied in lung walls and airways after inhalation of endotoxin or beta-1,3-glucan. In the water unsoluble form, beta-1,3-glucan caused a delayed response in terms of a decrease in macrophages and lymphocytes in the lung wall, 1 to 7 days after exposure but no invasion of neutrophils into the airways. When solubilized in 0.02 N NaOH, the cell response was the same as that observed after exposure to endotoxin.
authors.affiliation: Department of Environmental Medicine, University of Gothenburg, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Fogelmark
authors.forename: H
authors.initials: H
authors.lastname: Goto
authors.forename: K
authors.initials: K
authors.lastname: Yuasa
authors.forename: B
authors.initials: B
authors.lastname: Marchat
authors.forename: R
authors.initials: R
authors.lastname: Rylander
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D004731:Endotoxins / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D005936:Glucans / Q000008:administration & dosage / Q000633:toxicity*; D006168:Guinea Pigs; D007958:Leukocyte Count; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000139:chemically induced* / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D008297:Male; D009504:Neutrophils / Q000473:pathology; D047071:beta-Glucans
chemical_list: D004731:Endotoxins; D005936:Glucans; D047071:beta-Glucans; C033363:beta-1,3-glucan