Totally synthetic analogues of siastatin B. I. Optically active 2-acetamidopiperidine derivatives.
Totally synthetic analogues of siastatin B, optically active 2-acetamido-3,4,5-trihydroxypiperidines having the nitromethyl, aminomethyl and carboxyl branched groups at C-5 have been obtained from D-ribono-1,4-lactone by a stereospecific convergent method. Some analogues showed inhibitory activity against some glycosidases.
Kudo
T
T
Institute of Microbial Chemistry, Tokyo, Japan.
Nishimura
Y
Y
Kondo
S
S
Takeuchi
T
T
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D010880:Piperidines
D000900:Anti-Bacterial Agents; D010880:Piperidines; C011353:siastatin; D006026:Glycoside Hydrolases; D009439:Neuraminidase