Dermatonecrotic lesions in rabbits caused by neuraminidase.
In an attempt to study the role of neuraminidase in cholera vibrio pathogenesis, the dermatonecrotic effect of a purified neuraminidase preparation was studied in rabbits. The experiments demonstrated that dermatonecrotic lesions resulted from intracutaneous injection of a purified neuraminidase preparation (0.5 specific human dose or 1 NU) as well as significant doses of cholera toxoid containing the enzyme (4,12,18 specific human doses).
Isupov
I V
IV
Department of Pathohistology, Russian State Antiplague Research Institute, Microbe, Saratov.
Sagheyeva
O F
OF
Yeliseyev YuYu
Adamov
A K
AK
Sayapina
L V
LV
Kovalenko
N M
NM
Lukyanova
O I
OI
D000818:Animals; D002772:Cholera Toxin; D005260:Female; D007279:Injections, Subcutaneous; D008297:Male; D009336:Necrosis / Q000209:etiology; D009439:Neuraminidase / Q000633:toxicity*; D011817:Rabbits; D012867:Skin / Q000187:drug effects / Q000473:pathology*; D014121:Toxoids / Q000633:toxicity*
D014121:Toxoids; C038458:cholera toxoid; D002772:Cholera Toxin; D009439:Neuraminidase