Enumeration of T, B and natural killer peripheral blood cells of patients with multiple sclerosis and controls.
The median percentages of peripheral blood immunoglobulin-positive (Ig+) lymphocytes (8%, n = 46), CD8+ (12%, n = 49) and CD57+ cell numbers (5%, n = 37) of patients suffering from multiple sclerosis (MS) were significantly (p less than 0.05) lower than the values of age- and sex-matched healthy individuals (Ig+ cells: 13%, n = 46; CD8+ cells: 17%, n = 49; CD57+ cells: 9%, n = 37). Comparison of calculations on decreased peripheral blood cell counts and increased brain cell counts in MS patients revealed that sequestration of blood cells into the MS brain is a possible explanation of these findings.
Kreuzfelder
E
E
Institut für Medizinische Virologie, Universität-Gesamthochschule Essen, FRG.
Shen
G
G
Bittorf
M
M
Scheiermann
N
N
Thraenhart
O
O
Seidel
D
D
Grosse-Wilde
H
H
D000328:Adult; D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology*; D016516:CD4-CD8 Ratio; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000276:immunology*; D009422:Nervous System Diseases / Q000175:diagnosis / Q000276:immunology; D009460:Neurologic Examination; D013601:T-Lymphocytes / Q000276:immunology*