[Manometric evaluation of the effects of intravenous administration of glucagon, buscopan and papaverine on the contractile activity of the sphincter of Oddi].
Endoscopic manometric technique was used to investigate the effects of spasmolytic drugs on the sphincter of Oddi (s.O.) motility. 41 patients were randomly divided into 4 groups. In every patient the characteristics of the s.O. was monitored before and during 5 min. period after i.v. administration of: 20 mg buscopan, 1 mg glucagon, 40 mg papaverine or 2 ml of 0.9% NaCl solution. After buscopan administration the amplitude and frequency of phasic contractions of the s.O. were decreased as well as a baseline pressure in the s.O. Glucagon reduced frequency and amplitude of phasic contractions of the s.O. without influencing the baseline pressure. Papaverine reduced only frequency of phasic contractions. Physiological saline caused no change in pressure characteristics of the s.O.
Kaczor
R
R
Katedra i Klinika Gastroenterologii Slaskiej Akademii Medycznej w Katowicach.
Nowak
A
A
Nowakowska-Duława
E
E
Rybicka
J
J
D000328:Adult; D000368:Aged; D002086:Butylscopolammonium Bromide / Q000008:administration & dosage* / Q000494:pharmacology; D003137:Common Bile Duct Diseases / Q000503:physiopathology; D004177:Dipyrone / Q000008:administration & dosage* / Q000494:pharmacology; D004338:Drug Combinations; D005260:Female; D005934:Glucagon / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008365:Manometry / Q000379:methods; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects* / Q000502:physiology; D009130:Muscle, Smooth / Q000187:drug effects* / Q000503:physiopathology; D010208:Papaverine / Q000008:administration & dosage* / Q000494:pharmacology; D010276:Parasympatholytics / Q000008:administration & dosage* / Q000494:pharmacology; D009803:Sphincter of Oddi / Q000187:drug effects* / Q000503:physiopathology
D004338:Drug Combinations; D010276:Parasympatholytics; C020432:dypyrone, hyoscine butylbromide drug combination; D002086:Butylscopolammonium Bromide; D004177:Dipyrone; D005934:Glucagon; D010208:Papaverine
Manometryczna ocena wpływu dozylnego podania glukagonu, buskopanu i papaweryny na czynność skurczowa zwieracza Oddiego.