title: Evaluation of a reservoir device for metered-dose bronchodilator delivery to intubated adults. An in vitro study.
abstract: We investigated the use of a reservoir device for delivery of a MDI bronchodilator aerosol using a lung model of an intubated, mechanically ventilated adult.
  
  
  METHODS
  Albuterol (Proventil) was delivered with a MDI using three methods. In method 1, the MDI was attached directly onto the ETT using a commercially available actuator/adapter. In method 2, the Monaghan AeroVent reservoir was placed on the inspiratory limb of the ventilator circuit just before the patient Y connector. In method 3, the AeroVent was placed between the patient Y connector and the ETT. Standardized ventilator settings with a Servo 900C were used for all three methods (VE = 9.6 L; respiratory rate = 12 breaths per minute; TI = 20 percent of 1 s). Aerosol drug delivery was measured at the distal tip of the ETT using a spectrophotometric technique. Percentage of amount delivered was calculated from measured delivery of the MDI.
  
  
  RESULTS
  The MDI directly on the ETT delivered 7.3 percent of the total dose to the end of the ETT. The AeroVent on the inspiratory limb increased this to 32.1 percent and the AeroVent between the Y connector and the ETT delivered 29 percent. Both reservoir delivery methods delivered significantly more drug than direct placement of the MDI on the ETT (p less than 0.01) but did not differ from each other (p greater than 0.05).
  
  
  CONCLUSIONS
  Use of the AeroVent reservoir chamber significantly increased bronchodilator delivery by aerosol with an MDI in an adult lung model of an intubated patient on ventilatory support.
authors.affiliation: Cardiopulmonary Care Sciences, Georgia State University, Atlanta.
authors.forename: J L
authors.initials: JL
authors.lastname: Rau
authors.forename: R J
authors.initials: RJ
authors.lastname: Harwood
authors.forename: J L
authors.initials: JL
authors.lastname: Groff
mesh_terms: D000328:Adult; D000336:Aerosols; D000420:Albuterol / Q000008:administration & dosage; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D004867:Equipment Design; D006801:Humans; D007442:Intubation, Intratracheal; D008961:Models, Structural; D009330:Nebulizers and Vaporizers; D013053:Spectrophotometry; D012122:Ventilators, Mechanical
chemical_list: D000336:Aerosols; D001993:Bronchodilator Agents; D000420:Albuterol