Effects of triiodothyronine treatment on pharmacokinetic properties and metabolite formation of antipyrine in dwarf goats.
The influence of triiodothyronine (5 micrograms/kg of body weight, sc, q 12 h for 7 days) on antipyrine (AP, 25 mg/kg, IV) plasma elimination and urinary metabolite excretion was studied in castrated male dwarf goats. After triiodothyronine treatment, a significant increase in AP elimination was found. However, the observed changes in clearances for production of AP metabolites (nor-AP, 3-hydroxymethyl-AP; 4-hydroxy-AP, and 4,4'-dihydroxy-AP) do not suggest a clear selectivity of triiodothyronine toward any of the metabolic pathways of AP.
Offiah
V N
VN
Department of Veterinary Pharmacology, Pharmacy, and Toxicology, Faculty of Veterinary Medicine, State University of Utrecht, The Netherlands.
Nijmeijer
S M
SM
van Duin
C T
CT
Witkamp
R F
RF
van Miert
A S
AS
D000818:Animals; D000983:Antipyrine / Q000493:pharmacokinetics*; D006041:Goats / Q000378:metabolism*; D006207:Half-Life; D008297:Male; D014284:Triiodothyronine / Q000494:pharmacology*
D014284:Triiodothyronine; D000983:Antipyrine