title: Reversal of endothelin-1-induced contractions by isoproterenol without myosin dephosphorylation in tracheal smooth muscle.
abstract: Effects of isoproterenol on isometric force, and 20,000 Da myosin light chain (LC20) phosphorylation were examined in smooth muscle fibre strips from lamb trachea stimulated with endothelin-1 (ET-1). ET-1 induced a rapidly rising isometric tension which was coupled with a multiple site phosphorylation of LC20. Isoproterenol addition at the time of peak isometric force resulted in a brisk relaxation of the fibre strips. Myosin light chain phosphorylation, however, remained unaffected.
authors.affiliation: II Physiologisches Institüt, Universitat Heidelberg, Germany.
authors.forename: S S
authors.initials: SS
authors.lastname: Katoch
mesh_terms: D000818:Animals; D016232:Endothelins / Q000494:pharmacology*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D009218:Myosins / Q000378:metabolism*; D010766:Phosphorylation / Q000187:drug effects; D012756:Sheep; D014132:Trachea / Q000502:physiology*
chemical_list: D016232:Endothelins; D009218:Myosins; D007545:Isoproterenol