Serum interleukin 6 levels become elevated in acute myocardial infarction.
We have examined serum interleukin 6 (IL-6) levels in 12 patients with acute myocardial infarction (AMI). IL-6 levels became elevated in all patients, following the rise of serum creatine kinase (CK) activity. Peak IL-6 levels showed a good correlation with peak serum C-reactive protein (CRP) levels, while there was no direct relationship between peak IL-6 levels and peak CK activity. IL-6 mRNA was not detected in unstimulated "quiescent" rat cardiocytes cultured in serum-free medium, but its expression was induced by exposure of the cells to serum or ionomycin. These results show that IL-6 is synthesized in the myocardium and serum IL-6 levels become elevated in AMI, suggesting that IL-6 could affect the progression and/or healing processes of AMI.
Ikeda
U
U
Department of Cardiology, Jichi Medical School, Tochigi, Japan.
Ohkawa
F
F
Seino
Y
Y
Yamamoto
K
K
Hidaka
Y
Y
Kasahara
T
T
Kawai
T
T
Shimada
K
K
D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000276:immunology*; D013997:Time Factors
D015850:Interleukin-6; D002097:C-Reactive Protein; D003402:Creatine Kinase