[Catecholamine release--unpredictable side effects of calcium antagonists].
Animal and in vitro studies have shown that calcium antagonists release noradrenaline from sympathetic nerves. Several calcium antagonists interact with the catecholamine storage vesicles in a way that reduces the ability of the vesicles to take up and store catecholamines. Clinical studies indicate that verapamil and nifedipine increase release of noradrenaline from the heart during ischemia. Calcium antagonists thus have a direct catecholamine-releasing effect that may be clinically relevant (may induce negative side effects).
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Biokjemisk institutt, Universitetet i Bergen.
D000789:Angina, Unstable / Q000188:drug therapy / Q000503:physiopathology; D000818:Animals; D002121:Calcium Channel Blockers / Q000009:adverse effects* / Q000494:pharmacology; D006801:Humans; D009638:Norepinephrine / Q000378:metabolism*; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000378:metabolism*
D002121:Calcium Channel Blockers; D009638:Norepinephrine
Katekolaminfrisetting--kalsiumantagonistenes usikre følgesvenn.