title: Structure-retention index relationships for derivatized monosaccharides on non-polar gas chromatography columns.
abstract: A gas chromatographic method for predicting the retention index of a derivatized monosaccharide is presented. The procedures are especially useful to detect and predict minute quantities of sugars in biological or chemical samples. Monosaccharides are first converted to the alditols and then derivatized by acetylation, permethylation or silylation. The derivatized monosaccharide structure-retention index relationship that has been developed is useful in the identification of unknown monosaccharides that can be readily confirmed by gas chromatography-mass spectrometry.
authors.affiliation: Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco 94143-0446.
authors.forename: Z C
authors.initials: ZC
authors.lastname: Yang
authors.forename: J R
authors.initials: JR
authors.lastname: Cashman
mesh_terms: D000107:Acetylation; D002849:Chromatography, Gas / Q000379:methods*; D008745:Methylation; D009005:Monosaccharides / Q000032:analysis* / Q000737:chemistry; D013329:Structure-Activity Relationship; D013402:Sugar Alcohols / Q000032:analysis; D014297:Trimethylsilyl Compounds
chemical_list: D009005:Monosaccharides; D013402:Sugar Alcohols; D014297:Trimethylsilyl Compounds; C039293:trimethylchlorosilane