title: In situ mapping of the gene coding for a leucine zipper DNA binding protein (CDR62) to 16p12-16p13.1.
abstract: A cDNA clone encoding the major antigen (CDR62) associated with the antibody-induced paraneoplastic cerebellar degeneration has been used to identify the chromosomal location of the corresponding structural gene(s) by screening for its retention in a panel of rodent-human somatic cell hybrids. Having established the synteny of the gene with the autosome 16, we proceeded to its precise subregional mapping by in situ fluorescence hybridization with a recombinant lambda phage containing the genomic region homologous to the cDNA gene. The latter studies pin-pointed the chromosomal localization of the structural CDR62 gene within the interval 16p12-16p13.1.
authors.affiliation: Imperial Cancer Research Fund, London, Great Britain.
authors.forename: T
authors.initials: T
authors.lastname: Gress
authors.forename: A
authors.initials: A
authors.lastname: Baldini
authors.forename: M
authors.initials: M
authors.lastname: Rocchi
authors.forename: H
authors.initials: H
authors.lastname: Furneaux
authors.forename: J B
authors.initials: JB
authors.lastname: Posner
authors.forename: M
authors.initials: M
authors.lastname: Siniscalco
mesh_terms: D002871:Chromosome Banding; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D004247:DNA; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D005453:Fluorescence; D005796:Genes; D006801:Humans; D016350:Leucine Zippers / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D015183:Restriction Mapping
chemical_list: D004268:DNA-Binding Proteins; D004247:DNA