title: The pathogenesis of Munchausen syndrome. A review and case report.
abstract: The authors present a case of Munchausen syndrome notable for an extended premorbid length and lack of early identifiable antisocial behavior. The patient's life history has been reconstructed, and an integrated psychobiological evaluation of the patient is given including neuroanatomical, neurohormonal, and neuropsychological assessments. Frontotemporal cerebral atrophy and lack of thyroid-stimulating hormone response to thyroid-releasing hormone infusion were found. Although self-object losses did appear to precipitate the Munchausen syndrome in a step-wise fashion, it appears that central nervous system deterioration might have been related to the development of the disorder.
authors.affiliation: Department of Psychiatry, Vanderbilt University Medical Center, Nashville, Tennessee.
authors.forename: K S
authors.initials: KS
authors.lastname: Babe
authors.forename: A M
authors.initials: AM
authors.lastname: Peterson
authors.forename: P T
authors.initials: PT
authors.lastname: Loosen
authors.forename: T D
authors.initials: TD
authors.lastname: Geracioti
mesh_terms: D001284:Atrophy; D016241:Child of Impaired Parents / Q000523:psychology; D003866:Depressive Disorder / Q000523:psychology; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009110:Munchausen Syndrome / Q000523:psychology*; D010553:Personality Development; D012307:Risk Factors; D012803:Sick Role