Repair and regeneration: experimental aspects of spinal cord disease.
Regeneration of spinal cord neurons after injury depends on first, the presence of trophic factor(s) which prevent death, induce growth and maintain the viability of the neurone and second, the regenerating neurites must overcome glial scars, extracellular matrices and white matter barriers to reinnervate their target. Attempts at promoting regeneration by using grafts of prosthetic material, Schwann cells and neural tissue have largely been unsuccessful. Although growth could be induced, penetration of regenerating neurites through damaged areas of the spinal cord has been limited. There is as yet very little beneficial functional recovery.
Payne
J H
JH
Department of Anatomy and Developmental Biology, University College London, UK.
Wall
P D
PD
Chong
M S
MS
D000818:Animals; D002470:Cell Survival / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D006801:Humans; D009414:Nerve Growth Factors / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology*; D016501:Neurites / Q000502:physiology; D009474:Neurons / Q000502:physiology; D010525:Peripheral Nerves / Q000637:transplantation; D013116:Spinal Cord / Q000503:physiopathology / Q000601:surgery; D013118:Spinal Cord Diseases / Q000503:physiopathology* / Q000601:surgery
D009414:Nerve Growth Factors