Impairment by cyclosporin A of reperfusion-induced arrhythmias.
This study introduces the immunosuppressor, cyclosporin A, as a cardioprotective drug. This effect was analyzed during development of reperfusion/induced arrhythmias after 5-min period of coronary ligation in hearts of rats under anesthesia. The results indicate that cyclosporin, when given before coronary occlusion, at a dose of 20 mg/kg, effectively protects against the high incidence of arrhythmias and the fall in blood pressure induced by reperfusion. In addition, in inhibits the delivery of lactic dehydrogenase and creatine kinase enzymes to the plasma. We propose that the protective effect could be related with its well documented action to restrain Ca(2+)-induced damage of mitochondrial functions.
Arteaga
D
D
Departamento de Bioquímica, Instituto Nacional de Cardiología, Ignacio Chávez, D.F., México.
Odor
A
A
López
R M
RM
Contreras
G
G
Pichardo
J
J
García
E
E
Aranda
A
A
Chávez
E
E
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000517:prevention & control; D001794:Blood Pressure / Q000187:drug effects; D003402:Creatine Kinase / Q000097:blood; D016572:Cyclosporine / Q000494:pharmacology*; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008929:Mitochondria, Heart / Q000473:pathology; D009200:Myocardial Contraction / Q000187:drug effects; D015428:Myocardial Reperfusion Injury / Q000473:pathology / Q000517:prevention & control*; D009206:Myocardium / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains
D016572:Cyclosporine; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase