Management and response to treatment of Helicobacter pylori gastritis.
Gastritis associated with Helicobacter pylori was present in gastric biopsies from 24/95 (25%) children and adolescents undergoing endoscopy for recurrent abdominal pain and upper gastrointestinal symptoms. H pylori associated gastritis occurred mainly in older children (8-16 years) and was significantly associated with low socioeconomic class and a family history of peptic ulcer disease. Antral nodularity was a common endoscopic finding in H pylori positive children. Eighteen children, all over 5 years of age, were treated with tripotassium dicitratobismuthate (De-Nol) for two months and ampicillin for two weeks. In 12 children follow up gastric biopsies were obtained six weeks after completion of treatment. In 9/12 (75%) children H pylori was eradicated, and gastritis improved.
Mahony
M J
MJ
Department of Paediatrics, St James's University Hospital, Leeds.
Wyatt
J I
JI
Littlewood
J M
JM
D000367:Age Factors; D000667:Ampicillin / Q000008:administration & dosage; D000863:Antacids / Q000008:administration & dosage; D001706:Biopsy; D001729:Bismuth / Q000008:administration & dosage; D002648:Child; D004359:Drug Therapy, Combination; D005753:Gastric Mucosa / Q000473:pathology; D005756:Gastritis / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D009942:Organometallic Compounds / Q000008:administration & dosage; D015995:Prevalence; D011446:Prospective Studies; D012737:Sex Factors; D012959:Socioeconomic Factors
D000863:Antacids; D009942:Organometallic Compounds; D000667:Ampicillin; C002791:bismuth tripotassium dicitrate; D001729:Bismuth