title: Resting and maximal forearm skin blood flows are reduced in hypertension.
abstract: To find whether the vasodilator capacity of nonacral skin is reduced in hypertension, we measured forearm blood flow by venous occlusion plethysmography in 10 seated normotensive (mean +/- SD mean arterial pressure, 94 +/- 5 mm Hg) and 10 hypertensive (112 +/- 9 mm Hg) men at rest for 39 minutes while the forearm was heated with water at 42 degrees C, a maneuver known to selectively and maximally vasodilate skin. Blood pressure, measured every 5 minutes, did not change with heating. We found that in the normotensive group resting forearm blood flow was higher (3.64 +/- 1.12 versus 2.48 +/- 0.58 ml/100 ml tissue per minute, p less than 0.001; normotensive group versus hypertensive group) and resting forearm vascular resistance lower (30.17 +/- 10.99 versus 48.88 +/- 17.37 mm Hg.min.100 ml tissue per minute, p less than 0.05; normotensive group versus hypertensive group), and maximal forearm blood flow with local heating was higher (29.32 +/- 11.99 versus 18.19 +/- 4.50 ml/100 tissue per minute, p less than 0.018; normotensive group versus hypertensive group and vascular resistance lower (4.07 +/- 1.04 versus 6.54 +/- 1.17 mm Hg.min.100 ml tissue per minute, p less than 0.005; normotensive group versus hypertensive group). To find whether this degree and duration of local warming maximally vasodilated the skin in hypertensive subjects (as it does in normotensive subjects), we measured forearm skin blood flow before and during local heating plus 10 minutes of ischemia using a laser Doppler flowmeter.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284-7764.
authors.forename: P A
authors.initials: PA
authors.lastname: Carberry
authors.forename: A M
authors.initials: AM
authors.lastname: Shepherd
authors.forename: J M
authors.initials: JM
authors.lastname: Johnson
mesh_terms: D000328:Adult; D005542:Forearm / Q000098:blood supply* / Q000000981:diagnostic imaging; D006358:Hot Temperature; D006801:Humans; D006940:Hyperemia / Q000209:etiology / Q000503:physiopathology; D006973:Hypertension / Q000175:diagnosis / Q000503:physiopathology*; D007834:Lasers; D008297:Male; D008875:Middle Aged; D010991:Plethysmography; D012039:Regional Blood Flow; D012146:Rest; D012867:Skin / Q000098:blood supply; D014463:Ultrasonography / Q000295:instrumentation / Q000379:methods; D014655:Vascular Resistance; D014664:Vasodilation