title: Evaluation of the utility of a standard history questionnaire in assessing the neurological effects of solvents.
abstract: Using a standard battery of medical surveillance questions, a study was undertaken to determine if an increase in reported neurologic symptoms was resulting from solvent exposure at a pharmaceutical research, development, and manufacturing site. The prevalence of positive responses to 13 interval history questions pertaining to neurological symptoms was compared between those enrolled in exposed surveillance programs (n = 840) and those enrolled in other, non-solvent exposed surveillance programs (n = 1,042). The ratio of positive responders between the exposed and unexposed groups was used to generate a relative prevalence ratio (RPR). No significantly elevated RPRs were seen when the analysis was adjusted for the confounding factors of age, sex, smoking, alcohol use, noise exposure, and number of interval histories. These results suggest that workplace solvent exposures in the employees studied did not appear to result in obvious neurologic symptoms. However, low-level neurotoxic exposures can cause asymptomatic or sub-clinical disorders. Therefore, more sensitive neurotoxic surveillance systems need to be developed.
authors.affiliation: Merck & Co., Inc., Rahway, NJ 07065.
authors.forename: J A
authors.initials: JA
authors.lastname: Bukowski
authors.forename: E V
authors.initials: EV
authors.lastname: Sargent
authors.forename: B M
authors.initials: BM
authors.lastname: Pena
mesh_terms: D000328:Adult; D000368:Aged; D002246:Carbon Disulfide / Q000009:adverse effects; D005069:Evaluation Studies as Topic; D006801:Humans; D008297:Male; D008487:Medical History Taking; D008752:Methylene Chloride / Q000009:adverse effects; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000175:diagnosis; D009784:Occupational Diseases / Q000139:chemically induced* / Q000175:diagnosis; D016273:Occupational Exposure; D009790:Occupations; D012997:Solvents / Q000009:adverse effects*; D011795:Surveys and Questionnaires
chemical_list: D012997:Solvents; D008752:Methylene Chloride; D002246:Carbon Disulfide