Cytotoxic activity and IL-1 production in mice infected with Aspergillus niger.
In this report, we demonstrate an interaction between macrophages and T lymphocytes during A. nigr infection. Supernatants obtained after 48 hrs adherence of infected peritoneal macrophages were able to increase the cytotoxicity of T lymphocytes. Our results also indicate that macrophage supernatant (MS) from mice, in the first 5 days after challenge, is more active on T cell than MS produced later. Splenic T cells activated by IL-1 from mice at 5 days of infection show a significantly increased cytotoxicity, at 10 days after challenge, the cytotoxicity of T cells activated by IL-1 did not significantly differ from non-activated T cells.
Benedetto
N
N
Istituto di Microbiologia, I Facoltà di Medicina e Chirurgia, Università di Napoli, Italy.
Sabatini
P
P
Galdiero
E
E
Romano Carratelli
C
C
D000818:Animals; D001228:Aspergillosis / Q000276:immunology*; D001234:Aspergillus niger; D003602:Cytotoxicity, Immunologic; D007375:Interleukin-1 / Q000096:biosynthesis / Q000276:immunology*; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D007375:Interleukin-1