title: Effect of long-term calcitonin therapy by injection and nasal spray on the incidence of fractures in osteogenesis imperfecta.
abstract: The effect of calcitonin therapy by injection or nasal spray on the incidence of bone fractures was studied in patients with osteogenesis imperfecta. In contrast to injection of calcitonin, intranasal administration of calcitonin twice a week for 2 weeks, followed by 2 weeks of no therapy, was simple and seemed beneficial for decreasing bone fractures in patients with osteogenesis imperfecta.
authors.affiliation: Department of Pediatrics, Hiroshima Red Cross Hospital, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nishi
authors.forename: K
authors.initials: K
authors.lastname: Hamamoto
authors.forename: M
authors.initials: M
authors.lastname: Kajiyama
authors.forename: H
authors.initials: H
authors.lastname: Ono
authors.forename: M
authors.initials: M
authors.lastname: Kihara
authors.forename: K
authors.initials: K
authors.lastname: Jinno
mesh_terms: D000281:Administration, Intranasal; D000293:Adolescent; D002116:Calcitonin / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D005260:Female; D050723:Fractures, Bone / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D015994:Incidence; D007223:Infant; D007267:Injections; D008297:Male; D010013:Osteogenesis Imperfecta / Q000150:complications / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D002116:Calcitonin