Basic biochemistry of cell surface carbohydrates and aspects of the tissue distribution of histo-blood group ABH and related glycosphingolipids.
Cell surface carbohydrates may be protein- or lipid-linked. The structural polymorphism of the oligosaccharide chains is extensive due to variations in monosaccharide composition, carbohydrate sequence, branching, linkage position and linkage anomericity. Blood group ABH and related glycosphingolipids show a remarkable tissue-specific expression with possible implications in areas such as transfusion medicine, transplantation surgery and oncology. This communication gives a condensed description of the present knowledge of the tissue-specific distribution of histo-blood glycolipids in humans.
Holgersson
J
J
Department of Medical Biochemistry, University of Gothenburg, Sweden.
Breimer
M E
ME
Samuelsson
B E
BE
D000017:ABO Blood-Group System / Q000737:chemistry* / Q000378:metabolism; D000954:Antigens, Surface / Q000737:chemistry; D002240:Carbohydrate Sequence; D006028:Glycosphingolipids / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D007983:Lewis Blood Group Antigens / Q000737:chemistry / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000378:metabolism; D008969:Molecular Sequence Data; D014018:Tissue Distribution
D000017:ABO Blood-Group System; D000954:Antigens, Surface; D006028:Glycosphingolipids; D007983:Lewis Blood Group Antigens; D008562:Membrane Glycoproteins