[Effects of interferon preparations on the course of Salmonella infection (experimental and clinical studies)].
The effect of type I interferons on the process of experimental salmonellosis in mice and rabbits, as well as their effect on salmonellosis in patients was studied. It was shown that homologous interferon increased the animal survival rate, activated bactericidal activity of the phagocytic cells and increased elimination of the infectious agents from the host. The complex of the etiotropic and pathogenetic treatment of 32 patients with salmonellosis included human leukocytic interferon, leukinferon. It was administered intramuscularly in a dose of 1 x 10(4)-2 x 10(4) IU: three injections at intervals of 48 to 72 hours (the treatment course). The course was repeated 10 days after the last injection of the first course. Addition of leukinferon to the routine scheme of the medicinal treatment of salmonellosis provided recovery of all the patients without complications or appearance of the bacteria carriers (the observation period of more than 3 years).
Spivak
N Ia
NIa
Fil'chakov
I V
IV
Treshchinskiĭ
A I
AI
Kuznetsov
V P
VP
Zaritskiĭ
A M
AM
Belotskiĭ
S M
SM
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D000818:Animals; D016207:Cytokines / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D010587:Phagocytosis / Q000187:drug effects* / Q000276:immunology; D011817:Rabbits; D012481:Salmonella Infections, Animal / Q000276:immunology / Q000401:mortality / Q000628:therapy*; D012485:Salmonella typhi / Q000276:immunology*; D012486:Salmonella typhimurium / Q000276:immunology*; D014435:Typhoid Fever / Q000276:immunology / Q000401:mortality / Q000628:therapy*
D000276:Adjuvants, Immunologic; D016207:Cytokines; D004338:Drug Combinations; D007370:Interferon Type I; D016898:Interferon-alpha; C062252:leukinferon
Vliianie preparatov interferona na techenie salmonelleznoĭ infektsii (éksperimentalnoe i klinicheskoe issledovanie).