title: Effect of tidal volume and PEEP in ethchlorvynol-induced asymmetric lung injury.
abstract: We examined the effects of positive end-expiratory pressure (PEEP) and tidal volume on the distribution of ventilation and perfusion in a canine model of asymmetric lung injury. Unilateral right lung edema was established in 10 animals by use of a selective infusion of ethchlorvynol. Five animals were tested in the supine position (horizontal asymmetry) and five in the right decubitus position (vertical asymmetry). Raising PEEP from 5 to 12 cmH2O improved oxygenation despite a redistribution of blood flow toward the damage lung and a consistent decrease in total respiratory system compliance. This improvement paralleled a redistribution of tidal ventilation to the injured lung. This was effected primarily by a fall in the compliance of the noninjured lung due to hyperinflation. The effects of higher tidal volume were additive to those of PEEP. We propose that the major effect of PEEP in inhomogeneous lung injury is to restore tidal ventilation to a population of alveoli recruitable only at high airway pressures.
authors.affiliation: Critical Care Division, Royal Victoria Hospital, Montreal, Quebec, Canada.
authors.forename: L
authors.initials: L
authors.lastname: Blanch
authors.forename: C
authors.initials: C
authors.lastname: Roussos
authors.forename: S
authors.initials: S
authors.lastname: Brotherton
authors.forename: R P
authors.initials: RP
authors.lastname: Michel
authors.forename: M R
authors.initials: MR
authors.lastname: Angle
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D004285:Dogs; D004984:Ethchlorvynol / Q000633:toxicity*; D006439:Hemodynamics / Q000187:drug effects; D007442:Intubation, Intratracheal; D008170:Lung Compliance / Q000502:physiology; D008171:Lung Diseases / Q000139:chemically induced / Q000503:physiopathology*; D011175:Positive-Pressure Respiration; D011654:Pulmonary Edema / Q000378:metabolism / Q000503:physiopathology; D011659:Pulmonary Gas Exchange / Q000187:drug effects; D013990:Tidal Volume / Q000502:physiology
chemical_list: D004984:Ethchlorvynol