The effects of prenatal alcohol exposure on behavioral and neuroanatomical components of olfaction.
Prenatal alcohol exposure is associated with deficits in odor-associative learning in very young rat pups. One alternative explanation for these findings is that rather than a learning deficit per se, alcohol-exposed pups may display a sensory deficit. The present study was designed to examine the effects of prenatal alcohol exposure on behavioral and neuroanatomical components involved in olfaction. The subjects in this study were pups exposed to 35% ethanol-derived calorie (EDC) liquid diet from gestation days (GD) 6-20. Two control groups were included, a 0% EDC pair-fed and an ad lib lab chow group. In Experiment 1, respiratory response to a novel odor was examined in pups tested at either 3, 4, or 10 days of age. The 35% EDC offspring clearly detected the odor. Furthermore, there was an apparent alcohol-related development delay in respiratory rate as shown by a lower baseline respiratory rate at PN 3 relative to controls which was no longer apparent by PN 4. Experiment 2 examined the volume of two neuroanatomical structures involved in olfaction, the main olfactory bulb (MOB) and the vomeronasal organ (VNO) in 3-day-old pups. Prenatal alcohol exposure was associated with a decreased volume of the MOB although the VNO was unaffected.
Barron
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Department of Psychology, University of Kentucky, Lexington 40506-0044.
Riley
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D000818:Animals; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D006185:Habituation, Psychophysiologic / Q000187:drug effects*; D007858:Learning / Q000187:drug effects*; D009833:Olfactory Pathways / Q000187:drug effects*; D010465:Perception / Q000187:drug effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D012119:Respiration / Q000187:drug effects
D000431:Ethanol