Palate teratogenicity and embryotoxicity of cyclosporin A in mice.
Mice of the A/J and B10.A/SgSnJ strains were treated with 50 mg of cyclosporin A (CsA) per kg of body weight on day 12 of gestation. There were significantly more fetal resorptions in both the A/J and B10.A strain when treated with CsA than in controls treated with olive oil. A low frequency (7.6%) of isolated cleft palates were induced in the A/J strain, which was significantly greater than that observed in A/J mice treated with olive oil alone. No cleft palates were induced in B10.A, which suggests that any increase in susceptibility that was observed could not be attributed to H-2 linked genes.
Gasser
D L
DL
Department of Human Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104.
Yang
P
P
Buetow
K H
KH
D000014:Abnormalities, Drug-Induced / Q000196:embryology; D000704:Analysis of Variance; D000818:Animals; D002972:Cleft Palate / Q000139:chemically induced / Q000196:embryology*; D016572:Cyclosporine / Q000633:toxicity*; D005327:Fetal Resorption / Q000139:chemically induced; D016018:Least-Squares Analysis; D051379:Mice; D008815:Mice, Inbred Strains
D016572:Cyclosporine