Adipostatins A and B, new inhibitors of glycerol-3-phosphate dehydrogenase.
As a result of screening for inhibitors of glycerol-3-phosphate dehydrogenase, which may be effective to prevent corpulence, we isolated two inhibitors named adipostatin A and adipostatin B from the culture broth of Streptomyces cyaneus 2299-SV1. Their structures have been established to be 5-n-pentadecylresorcinol and 5-isopentadecylresorcinol, respectively. Adipostatin A and adipostatin B inhibited glycerol-3-phosphate dehydrogenase at the IC50 values of 4.1 microM and 4.5 microM, respectively. These compounds prevented triglyceride accumulation in 3T3-L1 cells at a concentration of the microM level.
Tsuge
N
N
Research Institute of House Food Ind. Co., Ltd., Osaka, Japan.
Mizokami
M
M
Imai
S
S
Shimazu
A
A
Seto
H
H
D016475:3T3 Cells; D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism; D005993:Glycerolphosphate Dehydrogenase / Q000037:antagonists & inhibitors*; D051379:Mice; D012118:Resorcinols / Q000737:chemistry / Q000378:metabolism*; D013302:Streptomyces / Q000378:metabolism; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D012118:Resorcinols; C076083:adipostatin B; D005993:Glycerolphosphate Dehydrogenase; C041328:adipostatin A