Conformational feature of neuroactive domoic acid: X-ray structural comparison with isodomoic acid A and alpha-kainic acid.
As an aid for developing a new type of potent insecticide acting on the neuromuscular junction, conformational characteristics of domoic acid and isodomoic acid A, the naturally occurring glutamate agonists, were investigated by X-ray crystal analyses. Conformational comparison with a neuroactive alpha-kainic acid provides information concerning the stereochemical feature responsible for the biological activity.
Nomoto
K
K
Suntory Institute for Bioorganic Research, Osaka, Japan.
Takemoto
T
T
Maeda
M
M
In
Y
Y
Doi
M
M
Inoue
M
M
Ishida
T
T
D007306:Insecticides / Q000737:chemistry*; D007608:Kainic Acid / Q000031:analogs & derivatives* / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D014961:X-Ray Diffraction
D007306:Insecticides; C012301:domoic acid; D007608:Kainic Acid