title: Prognostic relevance of pS2 status in association with steroid receptor status and proliferative activity in node-negative breast cancer.
abstract: Expression of the oestrogen-regulated pS2 protein was investigated on paraffin-embedded sections of primary breast tumours from 200 node-negative patients. Immunoreactivity was observed in 56% of the cases. pS2 expression was inversely correlated with tumour size and proliferative activity, whereas a direct correlation was observed with steroid receptor. 5-year relapse free survival was influenced by tumour size (P = 0.02), oestrogen receptor status (P less than 0.05), and proliferative activity (P less than 0.01). No difference in relapse-free survival was observed between patients subdivided according to pS2 expression alone. However, among patients with oestrogen-receptor-negative tumors, pS2 expression predicted a shorter relapse-free survival.
authors.affiliation: Oncologica Sperimentale C, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Cappelletti
authors.forename: D
authors.initials: D
authors.lastname: Coradini
authors.forename: E
authors.initials: E
authors.lastname: Scanziani
authors.forename: E
authors.initials: E
authors.lastname: Benini
authors.forename: R
authors.initials: R
authors.lastname: Silvestrini
authors.forename: G
authors.initials: G
authors.lastname: Di Fronzo
mesh_terms: D001943:Breast Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D011379:Prognosis; D011506:Proteins; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*; D012189:Retrospective Studies; D015996:Survival Rate; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins
chemical_list: D009363:Neoplasm Proteins; D011506:Proteins; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C051838:TFF1 protein, human; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins