Magnetoencephalography of focal cerebral ischemia in rats.
OBJECTIVE
The purpose of this study was to use magnetoencephalography to record magnetic field changes in the brain during middle cerebral artery occlusion.


METHODS
A direct-current electrocorticogram (two channels) and a direct-current magnetoencephalogram (seven channels) were simultaneously recorded from five rats subjected to middle cerebral artery occlusion for 1-2 hours.


RESULTS
Direct-current electrocorticographic and direct-current magnetoencephalographic signal deflections were observed after the onset of middle cerebral artery occlusion and occurred repeatedly throughout the ischemic period, with a mean +/- SD time interval of 12 +/- 5 minutes. A one-to-one correspondence of the electrocorticographic and magnetoencephalographic signal deflections was demonstrated.


CONCLUSIONS
Direct-current magnetoencephalography can provide a new noninvasive technique for studying depolarization and/or spreading depression in focal cerebral ischemia.
Chen
Q
Q
Department of Neurology, Henry Ford Hospital, Detroit, Mich. 48202.
Chopp
M
M
Chen
H
H
Tepley
N
N
D000818:Animals; D002545:Brain Ischemia / Q000175:diagnosis*; D002540:Cerebral Cortex / Q000503:physiopathology; D004569:Electroencephalography; D015225:Magnetoencephalography; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains