title: Is increased erythrocyte sodium-lithium countertransport a useful marker for diabetic nephropathy?
abstract: Genetic predisposition to essential hypertension has been proposed as a risk factor for the development of diabetic nephropathy in type 1 (insulin-dependent) diabetes mellitus. An increased sodium-lithium countertransport activity (NaLiCT) has been suggested as a genetic marker for essential hypertension. We therefore evaluated NaLiCT in diabetic patients with (N = 39) or without (N = 23) diabetic nephropathy (DNP), patients with non-diabetic renal diseases (N = 42) and in healthy controls (N = 24). The NaLiCT was elevated in both diabetic patient groups compared to healthy controls (median 244; range 134 to 390 mumol.liter cells-1.hr-1), but was not different in patients with DNP (median 314; range 162 to 676), without DNP (median 325; range 189 to 627) and patients with non-diabetic renal disease (median 300; range 142 to 655). The genetic predisposition to DNP is illustrated by the fact that diabetic sibs of probands with DNP showed a higher occurrence of DNP than diabetic sibs of patients without DNP. We analyzed whether familial DNP clustered with an increased NaLiCT. The NaLiCT in sibs concordant for the presence of DNP (N = 10; median 307; range 217 to 428 mumol.liter cells-1.hr-1) was not significantly different from that in sibs concordant for absence of DNP (N = 15; median 279; range 189 to 442). We conclude that erythrocyte sodium-lithium countertransport activity cannot be used as a marker to identify patients at risk for the development of diabetic nephropathy.
authors.affiliation: Department of Medicine, University Hospital, Nijmegen, The Netherlands.
authors.forename: L D
authors.initials: LD
authors.lastname: Elving
authors.forename: J F
authors.initials: JF
authors.lastname: Wetzels
authors.forename: J J
authors.initials: JJ
authors.lastname: De Pont
authors.forename: J H
authors.initials: JH
authors.lastname: Berden
mesh_terms: D000328:Adult; D017920:Antiporters; D015415:Biomarkers; D002352:Carrier Proteins / Q000097:blood*; D003928:Diabetic Nephropathies / Q000097:blood* / Q000235:genetics; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D008094:Lithium / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D012016:Reference Values
chemical_list: D017920:Antiporters; D015415:Biomarkers; D002352:Carrier Proteins; C045885:sodium-lithium countertransporter; D008094:Lithium