title: Interleukin-6 activity in urine and serum in patients with bladder carcinoma.
abstract: To investigate the correlation between interleukin-6 and urothelial neoplasms, interleukin-6 activities in blood and urine samples of patients with bladder carcinoma were measured with a proliferation assay using an interleukin-6 dependent murine hybridoma clone, MH60.BSF2. A total of 43 patients and 15 normal volunteers were entered into this study. All of the patients were examined preoperatively and 26 were reexamined more than 6 days postoperatively to eliminate the effect of surgical injury on interleukin-6 secretion. The interleukin-6 titers in urine and serum increased in accordance with the progression of the tumor stage, and tumor removal induced a remarkable decrease in the titer of urinary interleukin-6. Although the interleukin-6-producing site has not been elucidated yet, our study suggests that interleukin-6 activity in bladder carcinoma patients may reflect the immunoreaction against the tumor in local urothelium.
authors.affiliation: Department of Urology, Osaka University Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Seguchi
authors.forename: K
authors.initials: K
authors.lastname: Yokokawa
authors.forename: H
authors.initials: H
authors.lastname: Sugao
authors.forename: E
authors.initials: E
authors.lastname: Nakano
authors.forename: T
authors.initials: T
authors.lastname: Sonoda
authors.forename: A
authors.initials: A
authors.lastname: Okuyama
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000097:blood / Q000378:metabolism* / Q000473:pathology / Q000652:urine; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood / Q000378:metabolism* / Q000652:urine; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011184:Postoperative Period; D011300:Preoperative Care; D001749:Urinary Bladder Neoplasms / Q000097:blood / Q000378:metabolism* / Q000473:pathology / Q000652:urine
chemical_list: D015850:Interleukin-6