Renal involvement in mice experimentally infected with Toxocara canis embryonated eggs.
Histological examination of kidneys from mice experimentally infected with Toxocara canis embryonated eggs demonstrated the presence of a segmental or diffuse mesangioproliferative glomerulonephritis. Immunohistochemical studies established that renal alterations were associated with glomerular deposits of IgG, IgM and third component of complement (C3). These findings suggest that an immunomediated mechanism might possibly be involved in the genesis of kidney damage observed in mice infected with T. canis embryonated eggs.
Casarosa
L
L
Dipartimento di Patologia Animale, Facoltà di Medicina Veterinaria, Università di Pisa, Italy.
Papini
R
R
Mancianti
F
F
Abramo
F
F
Poli
A
A
D000818:Animals; D003176:Complement C3 / Q000032:analysis; D004195:Disease Models, Animal; D005921:Glomerulonephritis / Q000209:etiology* / Q000473:pathology; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007150:Immunohistochemistry; D007668:Kidney / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D051379:Mice; D008807:Mice, Inbred BALB C; D008854:Microscopy, Electron; D014120:Toxocariasis / Q000150:complications* / Q000473:pathology
D003176:Complement C3; D007074:Immunoglobulin G; D007075:Immunoglobulin M