Late-onset atypical psychosis: a case involving neuroleptic drug toxicity and autoimmune serological abnormalities.
Serious or significant neuroleptic toxicity (Kurlan et al. 1984; Lazarus 1985; Levenson 1985; Pearlman 1986) may complicate the diagnosis and management of patients who develop acute medical problems while under treatment with neuroleptics (Levenson and Simpson 1986). We have found that in some cases it is difficult, if not impossible, to determine whether neuroleptics have contributed to the cause of an acute medical illness, or if the occurrence of acute medical problems precipitated the signs of neuroleptic toxicity by altering the disposition or the pharmacologic effects of the drugs.
Lee
K
K
Psychiatry Service, VA Medical Center, Brockton, MA 02401.
Romero
J A
JA
Tsuang
M
M
D001327:Autoimmune Diseases / Q000150:complications* / Q000175:diagnosis / Q000523:psychology; D003937:Diagnosis, Differential; D006220:Haloperidol / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000175:diagnosis* / Q000523:psychology; D009459:Neuroleptic Malignant Syndrome / Q000175:diagnosis* / Q000523:psychology; D009460:Neurologic Examination / Q000187:drug effects; D011618:Psychotic Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology
D006220:Haloperidol