Reduced L-arginine/lysine and L-arginine/aspartic acid ratios in aorta from Watanabe heritable hyperlipidaemic (WHHL) rabbit.
L-Arginine is the endogenous source of nitric oxide in the endothelial cells of blood vessels. In thoracic aorta from Watanabe heritable hyperlipidaemic (WHHL) rabbits, the L-arginine/lysine and L-arginine/aspartic acid ratios were reduced in comparison to New Zealand rabbit aorta. This result indicates that a variation in aortic arginine/lysine or arginine/aspartic acid ratios could be related to the hyperlipidaemic status.
Chinellato
A
A
Department of Pharmacology, University of Padua, Padova, Italy.
Ragazzi
E
E
Polverino De Laureto
P
P
Fassina
G
G
D000818:Animals; D001013:Aorta, Thoracic / Q000378:metabolism*; D001120:Arginine / Q000378:metabolism*; D001224:Aspartic Acid / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D006949:Hyperlipidemias / Q000378:metabolism*; D008239:Lysine / Q000378:metabolism*; D011817:Rabbits
D001224:Aspartic Acid; D001120:Arginine; D002784:Cholesterol; D008239:Lysine