title: Mechanical assistance of the left ventricle: acute effect on cardiac performance and coronary flow of different perfusion patterns.
abstract: Mechanical circulatory assistance by ventricular assist devices provides an opportunity to influence the aortic pressure pattern, which may affect ventricular loading and coronary perfusion. The effect of synchronous, pulsatile coronary perfusion of an assist device-supported left ventricle has not been studied. To analyze the effect of different perfusion patterns on left ventricular performance and on coronary flow, independent of pressure and volume loading, we used three different modes of aortic perfusion in an isometric, contracting, isolated canine heart model. The effect of nonpulsatile, counter-pulsatile, and copulsatile coronary perfusion was analyzed in four subgroups to simulate different, clinically relevant situations (using two different ventricular end-diastolic volumes [normal and high] and two mean perfusion pressures [normal and critically low]). Our experiments demonstrated that total coronary flow is optimized by making the perfusion pressure pulsatile and by synchronously timing the pump systole with ventricular diastole (counterpulsation). Under identical conditions of preload and mean perfusion pressure, coronary flow and left ventricular contractility were decreased during non-pulsatile and copulsatile aortic perfusion when compared with counterpulsatile flow. There were no significant differences between the nonpulsatile and copulsatile modes. We conclude from these data that a nonejecting, but contracting, left ventricle will have improved systolic function and coronary blood flow if the coronary perfusion pressure is synchronized in a counterpulsatile manner. This is a significant implication for mechanical left ventricular assist devices when used to promote myocardial recovery.
authors.affiliation: Division of Cardiothoracic Surgery, Beth Israel Hospital, Harvard Medical School, Boston, Mass.
authors.forename: F
authors.initials: F
authors.lastname: Bellotto
authors.forename: R G
authors.initials: RG
authors.lastname: Johnson
authors.forename: J
authors.initials: J
authors.lastname: Watanabe
authors.forename: M J
authors.initials: MJ
authors.lastname: Levine
authors.forename: A
authors.initials: A
authors.lastname: Franklin
authors.forename: R M
authors.initials: RM
authors.lastname: Weintraub
mesh_terms: D000818:Animals; D001794:Blood Pressure; D003326:Coronary Circulation; D004285:Dogs; D004562:Electrocardiography; D006321:Heart / Q000502:physiology*; D006353:Heart-Assist Devices; D066298:In Vitro Techniques; D007773:Lactates / Q000378:metabolism; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption; D010477:Perfusion
chemical_list: D007773:Lactates