Effect of age on [3H]nisoxetine binding to uptake sites for norepinephrine in the locus coeruleus of humans.
[3H]Nisoxetine ([3H]NIS) was used to measure uptake sites for norepinephrine (NE) in the locus coeruleus (LC) of humans. Regression analysis demonstrated an inverse correlation between age and the binding of [3H]NIS to NE uptake sites in the LC (r = -0.6; P less than 0.01). Since considerable cell loss has been reported to occur with age in the human LC, the decreased binding of [3H]NIS probably reflects loss of LC cells rather than a down-regulation of these sites.
Tejani-Butt
S M
SM
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104.
Ordway
G A
GA
D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism*; D001345:Autoradiography; D001692:Biological Transport; D005260:Female; D005473:Fluoxetine / Q000031:analogs & derivatives* / Q000378:metabolism; D006801:Humans; D008125:Locus Coeruleus / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000037:antagonists & inhibitors / Q000378:metabolism*; D012044:Regression Analysis; D014316:Tritium
D005473:Fluoxetine; D014316:Tritium; C011386:nisoxetine; D009638:Norepinephrine