Exacerbation of parkinsonism by tacrine.
A patient with Alzheimer's disease and mild features of parkinsonism was treated with tacrine. Tremor and gait dysfunction worsened but responded to the addition of levodopa without adversely affecting cognitive function. The implications for experimental treatment strategies of patients with combined Alzheimer's and Parkinson's disease are discussed.
Ott
B R
BR
Department of Medicine, Roger Williams Medical Center, Brown University, Providence, Rhode Island 02908.
Lannon
M C
MC
D000368:Aged; D000544:Alzheimer Disease / Q000150:complications / Q000188:drug therapy / Q000523:psychology; D004576:Electromyography; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D010300:Parkinson Disease / Q000150:complications* / Q000523:psychology; D013619:Tacrine / Q000009:adverse effects* / Q000627:therapeutic use
D007980:Levodopa; D013619:Tacrine