Calcium channel blockers: protective effects in ischemic acute renal failure.
Studies in heart, liver, and kidney have provided evidence that calcium is an important factor in cell injury. Calcium channel blockers are used with increasing frequency in ischemic and toxic renal failure. In this review the available data on the effects of calcium channel blockers in animal models of ischemic renal failure are presented and possible mechanisms of protective actions are discussed.
Wetzels
J F
JF
Department of Medicine, University of Colorado School of Medicine, Denver.
Burke
T J
TJ
Schrier
R W
RW
D058186:Acute Kidney Injury / Q000188:drug therapy*; D000818:Animals; D002118:Calcium / Q000502:physiology*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004231:Diuresis / Q000187:drug effects; D009318:Natriuresis / Q000187:drug effects; D015427:Reperfusion Injury / Q000188:drug therapy*
D002121:Calcium Channel Blockers; D002118:Calcium