title: [Chemically-induced scleroderma].
abstract: Scleroderma-like diseases can be induced by a number of chemical compounds, such as plastics, solvents and drugs. Contaminated rapeseed oil was the cause of the toxic oil syndrome and L-tryptophan induces the so-called eosinophilia-myalgia-syndrome. On the other hand, paraffin and silicon can trigger so-called adjuvant disease, while long-term exposure to silica can lead to idiopathic scleroderma (associated with silicosis in some cases). In addition to the clinical features, some pathogenetic data in the literature, such as genetic factors (HLA, chromosomal anomalies, enzyme deficiencies) and the metabolism of chlorinated ethylenes via reactive epoxide intermediate products, and our own findings are reported. Silica-induced scleroderma cannot be distinguished from the idiopathic form by epidemiological, clinical or immunological studies or by parameters referring to the blood vessels or collagen metabolism. In cell culture studies it has been shown that macrophages/monocytes release IL1, IL6 and TNF after ingestion of silica, which affects fibroblasts, T-helper cells and endothelial cells. Comparative results from the silicosis literature are reported. Finally, the possibly stimulating role of ionizing irradiation (uranium mining) in favouring the development of scleroderma is discussed.
authors.affiliation: Klinik und Poliklinik für Hautkrankheiten, Universität Leipzig.
authors.forename: U F
authors.initials: UF
authors.lastname: Haustein
authors.forename: V
authors.initials: V
authors.lastname: Ziegler
authors.forename: K
authors.initials: K
authors.lastname: Herrmann
mesh_terms: D005030:Ethylenes / Q000009:adverse effects; D006801:Humans; D011791:Quartz / Q000009:adverse effects; D012307:Risk Factors; D012595:Scleroderma, Systemic / Q000139:chemically induced* / Q000235:genetics; D012828:Silicones / Q000009:adverse effects
chemical_list: D005030:Ethylenes; D012828:Silicones; D011791:Quartz
vernacular_title: Chemisch induzierte Sklerodermie.