title: Muscle lactate dehydrogenase activity is decreased in murine motor neuron disease.
abstract: Lactic dehydrogenase (LDH) activity was examined in affected skeletal muscles of the wobbler mouse, a murine model in which denervation follows degeneration of spinal cord motoneurons. Average biceps brachii LDH activity was reduced at 7 and 15 but not at 3 postnatal weeks. These results demonstrate a progressive alteration in muscle energy metabolism in a natural model of motor neuron disease.
authors.affiliation: Department of Neurology, University of New Mexico School of Medicine, Albuquerque 87131.
authors.forename: R N
authors.initials: RN
authors.lastname: Mandler
authors.forename: J M
authors.initials: JM
authors.lastname: Baca
mesh_terms: D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D005260:Female; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008297:Male; D051379:Mice; D008818:Mice, Neurologic Mutants; D009046:Motor Neurons; D024510:Muscle Development; D009132:Muscles / Q000201:enzymology*; D009468:Neuromuscular Diseases / Q000201:enzymology*; D012016:Reference Values
chemical_list: D007770:L-Lactate Dehydrogenase