[Experimental and clinical study of arterial damage induced by anti-cancer drug infusion].
In order to reduce the arterial damage following arterial chemo-infusion, arterial reaction to anti-cancer drugs and Corticosteroid were studied experimentally and clinically. In experiment, chemo-infusions (Mitomycin C, Adriamycin, Cisplatin) with or without Corticosteroid were carried out into the auricular and femoral arteries of rabbits, and the arterial changes were examined angiographically and histopathologically. The histologic examination showed the damages of various degrees characterized by intimal edema with pyknosis of endothelial cells, thrombus formation and detachment of intimal layer. The degree and frequency of the damage increased as the drug dose and concentration increased. However, higher blood flow and Corticosteroid could reduce the damages in some degrees. Clinically, bronchial arterial infusion of Cisplatin with or without Corticosteroid were studied. In conclusion, when angiography following ACI reveals narrowing and/or irregularity of the target artery, reduction of drug concentration and dose as well as elongation of infusion intervals are advised.
Ueda
E
E
Department of Radiology, Kobe University School of Medicine.
Sako
M
M
Hirota
S
S
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000792:Angiography; D000818:Animals; D001158:Arteries / Q000187:drug effects / Q000473:pathology*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology*; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000009:adverse effects*; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology; D016685:Mitomycin / Q000008:administration & dosage / Q000009:adverse effects*; D011817:Rabbits
D000305:Adrenal Cortex Hormones; D016685:Mitomycin; D004317:Doxorubicin; D002945:Cisplatin