title: [Poisoning with long-acting anticoagulants].
abstract: Until last year, all rodenticides that could be marketed freely in Norway contained anticoagulants. In recent years rodenticide manufacturers have replaced warfarin by so-called "superwarfarins" as the active substances in their products. The latter are more toxic, also in a human context. One single intake can produce an anticoagulatory effect which may last for 50 to 60 days, and the intake of larger quantities over a period of time can induce the same effect for close to seven months. We describe two patients who were poisoned with bromadiolone. One of them had to be treated with vitamin K1 for six months. Reference is further made to similar casuistics described in the literature. Finally, the authors outline a recommended method of treatment.
authors.affiliation: Medisinsk avdeling, Sandnessjøen sykehus.
authors.forename: B
authors.initials: B
authors.lastname: Haug
authors.forename: L
authors.initials: L
authors.lastname: Schjødt-Iversen
authors.forename: J
authors.initials: J
authors.lastname: Rygh
mesh_terms: D015110:4-Hydroxycoumarins / Q000506:poisoning*; D000328:Adult; D000925:Anticoagulants / Q000506:poisoning*; D003692:Delayed-Action Preparations; D006801:Humans; D008297:Male; D011041:Poisoning / Q000628:therapy; D012378:Rodenticides / Q000506:poisoning*; D013406:Suicide, Attempted
chemical_list: D015110:4-Hydroxycoumarins; D000925:Anticoagulants; D003692:Delayed-Action Preparations; D012378:Rodenticides; C021636:bromadiolone
vernacular_title: Forgiftninger med langtidsvirkende antikoagulanter.