Effect of photosensitizers in chemical and biological processes: the MTO mechanism in photodynamic therapy.
It is suggested that in the course of the application of photosensitizers irradiated for cancer therapy a real competition occurs between the singlet oxygen mediated effects and the interactions between the triplet photosensitizers and doublet radicals formed in tumor cells while processes between photosensitizer radicals and molecules are negligible. This hypothesis is strongly supported by experimental findings and reveals a novel approach for the synthesis of new photosensitizers.
Gál
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Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest.
D016166:Free Radical Scavengers; D005609:Free Radicals; D006801:Humans; D007700:Kinetics; D008433:Mathematics; D008962:Models, Theoretical; D010778:Photochemotherapy; D011838:Radiation-Sensitizing Agents
D016166:Free Radical Scavengers; D005609:Free Radicals; D011838:Radiation-Sensitizing Agents