Life-threatening allergic reaction to clozapine.
Clozapine, an 'atypical' antipsychotic drug, rarely induces allergic complications, which usually present as cutaneous reactions. We report the case of a 69-year-old woman, suffering from chronic schizophrenia, who developed an allergic asthmatic reaction following clozapine therapy. Intensive-care treatment was necessary. The reaction could be repeated by further exposure to the drug. Skin tests for hypersensitivity were negative.
Stoppe
G
G
University of Goettingen, Department of Psychiatry, Germany.
Müller
P
P
Fuchs
T
T
Rüther
E
E
D000368:Aged; D001249:Asthma / Q000139:chemically induced*; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D012563:Schizophrenia, Paranoid / Q000188:drug therapy* / Q000523:psychology
D003024:Clozapine