[The role of free oxygen radicals in myocardial damage from ischemia/reperfusion, in chronic obstructive bronchopneumopathy and in aging].
During the last few years, several observations point out that oxygen-free radicals may play a pivotal role in the development of myocardial ischaemic/reperfusion injury, chronic obstructive pulmonary disease (COPD) and aging. With particular reference to acute myocardial ischaemic syndrome, these compounds may account for reperfusion-mediated ventricular arrhythmias, myocardial stunning and cell death. Such molecules may also be involved in lung damage during the course of COPD. In this regard, polymorphonuclear cell (PMN) recruitment at myocardial and/or lung level play an important role in oxygen-free radical overproduction. Several factors may, in fact, trigger PMN adhesion, respiratory burst and/or lysosomal enzyme release, this leading to a deleterious effect for the host. As far as elderly is concerned, evidence has been provided for a strict relationship between oxygen-free radical generation and metabolic rate. Nevertheless, the occurrence of PMN impaired functions and malnutrition in aged subjects gives rise to an enhanced synthesis of these compounds. All together, these findings outline the toxicity of oxygen-derived radicals and suggest the usefulness of a therapeutical approach to antagonize their effects.
Antonaci
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Cattedra di Patologia medica, Istituto di Medicina clinica, Università, Bari.
Tortorella
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C
D000375:Aging / Q000378:metabolism*; D001996:Bronchopneumonia / Q000209:etiology* / Q000378:metabolism; D002908:Chronic Disease; D003327:Coronary Disease / Q000209:etiology* / Q000378:metabolism; D005609:Free Radicals / Q000009:adverse effects; D006801:Humans; D015428:Myocardial Reperfusion Injury / Q000209:etiology* / Q000378:metabolism; D009504:Neutrophils / Q000378:metabolism; D010100:Oxygen / Q000009:adverse effects*; D016897:Respiratory Burst / Q000502:physiology
D005609:Free Radicals; D010100:Oxygen
Ruolo dei radicali liberi dell'ossigeno nel danno miocardico da ischemia/riperfusione, nella broncopneumopatia cronica ostruttiva e nell'invecchiamento.