title: Behavior of inhibitory and excitatory propriobulbar respiratory neurons during fictive vomiting.
abstract: The behavior of propriobulbar respiratory neurons was studied during fictive vomiting in decerebrate, paralyzed, artificially ventilated cats. Fictive vomiting was identified by a characteristic series of synchronous phrenic and abdominal nerve bursts, induced by electrical stimulation of abdominal vagal afferents and/or i.v. infusion of emetic drugs. Data were obtained from inspiratory neurons having decrementing (I-DEC) or constant (I-CON) discharge patterns and expiratory decrementing (E-DEC) neurons located in the Bötzinger complex and adjacent rostral ventral respiratory group. These neurons are known to make excitatory (I-CON) and inhibitory (I-DEC, E-DEC) connections with a variety of medullary respiratory neurons. During fictive vomiting: 8 of 14 I-DEC neurons fired in phase with synchronous bursts of phrenic and abdominal nerve discharge; the other 6 were silent. Of 12 I-CON neurons, 5 fired in phase with phrenic and abdominal bursts; 7 were silent. All (6) E-DEC neurons were either silent or fired weakly between bursts of phrenic and abdominal discharges. The possible roles of I-DEC and I-CON neurons in actively reorganizing the behavior of other respiratory neurons during fictive vomiting are discussed. In particular, the firing of many I-DEC neurons was found to be appropriate to inhibit inspiratory, and two types of expiratory, bulbospinal neurons during fictive vomiting.
authors.affiliation: Rockefeller University, New York, NY 10021.
authors.forename: A D
authors.initials: AD
authors.lastname: Miller
authors.forename: K
authors.initials: K
authors.lastname: Ezure
mesh_terms: D000818:Animals; D001933:Brain Stem / Q000502:physiology* / Q000503:physiopathology; D002415:Cats; D004558:Electric Stimulation; D005260:Female; D008297:Male; D009474:Neurons / Q000502:physiology*; D010791:Phrenic Nerve / Q000502:physiology* / Q000503:physiopathology; D012119:Respiration / Q000502:physiology*; D012132:Respiratory Muscles / Q000294:innervation*; D014630:Vagus Nerve / Q000502:physiology* / Q000503:physiopathology; D014839:Vomiting / Q000503:physiopathology*