title: Concentration of cefuroxime in mandibular alveolar bone following a single preoperative dose.
abstract: A pilot study was undertaken on 12 patients undergoing the bilateral removal of impacted mandibular wisdom teeth to determine the level of cefuroxime sodium within the alveolar bone adjacent to the third molar teeth following a single preoperative intravenous administration. The results indicated that a single 1.5 g intravenous bolus injection provided satisfactory alveolar bone concentrations for routine antibiotic prophylaxis at the time of wisdom tooth removal.
authors.affiliation: Unit of Oral Surgery and Oral Medicine, Birmingham Dental School.
authors.forename: P G
authors.initials: PG
authors.lastname: Rout
authors.forename: J W
authors.initials: JW
authors.lastname: Frame
mesh_terms: D000539:Alveolar Process / Q000737:chemistry*; D002444:Cefuroxime / Q000032:analysis* / Q000097:blood / Q000627:therapeutic use; D006801:Humans; D008334:Mandible / Q000737:chemistry*; D008964:Molar, Third / Q000601:surgery; D011292:Premedication; D011446:Prospective Studies; D013997:Time Factors; D014081:Tooth Extraction; D014095:Tooth, Impacted / Q000601:surgery
chemical_list: D002444:Cefuroxime