title: Determination of the acyl moieties of the antibiotic complex A40926 and their relation with the membrane lipids of the producer strain.
abstract: Structures of the fatty acid residues characterizing the various components of A40926 were determined by gas chromatography/mass spectrometry on the methyl esters obtained by methanolysis of the complex. The results confirm the residues previously assigned to Factor A (n-undecanoic acid) and B (10-methyl-undecanoic acid) and establish the residues of Factor A1 (9-methyl-decanoic acid), B1 (n-dodecanoic acid), RS1 (8-methyl-nonanoic acid), RS2 (n-decanoic acid), and RS3 (n-tridecanoic acid). As the Actinomadura species contain in their mycelia large quantities of C15-C17 fatty acid residues as membrane phospholipids, these mycelia were saponified and the fatty acids obtained were analyzed as above. There is a close correlation between the fatty acid content of A40926 complex and that of the longer homologues in the producer mycelia.
authors.affiliation: Marion Merrell Dow Research Institute, Lepetit Research Center, Grenezano, Varese, Italy.
authors.forename: L F
authors.initials: LF
authors.lastname: Zerilli
authors.forename: D M
authors.initials: DM
authors.lastname: Edwards
authors.forename: A
authors.initials: A
authors.lastname: Borghi
authors.forename: G G
authors.initials: GG
authors.lastname: Gallo
authors.forename: E
authors.initials: E
authors.lastname: Selva
authors.forename: M
authors.initials: M
authors.lastname: Denaro
authors.forename: G C
authors.initials: GC
authors.lastname: Lancini
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D005227:Fatty Acids / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D006020:Glycopeptides / Q000737:chemistry; D008563:Membrane Lipids / Q000032:analysis*; D009618:Nocardiaceae / Q000166:cytology*; D017334:Teicoplanin / Q000031:analogs & derivatives
chemical_list: C054981:A 40926; D000900:Anti-Bacterial Agents; D005227:Fatty Acids; D006020:Glycopeptides; D008563:Membrane Lipids; D017334:Teicoplanin