title: Oxygen consumption after flumazenil reversal.
abstract: The effect of flumazenil reversal of midazolam-induced anesthesia on whole body oxygen uptake (VO2) was investigated in a double-blind trial in 48 patients (ASA, 1 or 2) undergoing elective surgery under general anesthesia. VO2 was measured in spontaneously breathing patients during recovery from anaesthesia induced with midazolam 0.25 mg.kg-1 and maintained with nitrous oxide 60% in oxygen and halothane. The level of sedation was evaluated by a subjective score. To reverse midazolam-induced anesthesia, patients were randomly allocated to receive placebo or flumazenil (6 micrograms.kg-1). No significant changes in VO2 (160 +/- 53 vs 150 +/- 39 ml.min-1.m-2 or sedation score (2.5 +/- 1.0 vs 2.1 +/- 0.9) were observed in the placebo group. After flumazenil administration, the sedation score significantly (P less than 0.05) improved (2.9 +/- 1.0 vs 1.3 +/- 0.8) whereas no significant change in VO2 was observed (158 +/- 67 vs 157 +/- 61 ml O2.min-1.m-2). These data show that reversal of benzodiazepine effects with flumazenil resulted in no significant change in oxygen uptake.
authors.affiliation: Department of Anesthesiology, Hospital Henri Mondor, Creteil, France.
authors.forename: P
authors.initials: P
authors.lastname: Duvaldestin
authors.forename: C
authors.initials: C
authors.lastname: Lebrault
authors.forename: H
authors.initials: H
authors.lastname: Costes
authors.forename: N
authors.initials: N
authors.lastname: Barral
authors.forename: E
authors.initials: E
authors.lastname: Raimbault
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D005260:Female; D005442:Flumazenil / Q000494:pharmacology*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000037:antagonists & inhibitors*; D008297:Male; D008874:Midazolam / Q000037:antagonists & inhibitors*; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects*; D013514:Surgical Procedures, Operative
chemical_list: D006993:Hypnotics and Sedatives; D005442:Flumazenil; D008874:Midazolam