title: Structural brain correlates of neurologic abnormalities in multiple sclerosis.
abstract: We examined the relationship between cerebral magnetic resonance imaging (MRI) findings and urinary dysfunction in 70 consecutive patients with definite multiple sclerosis. MRI-weighted lesion scores for seven different brain regions were recorded according to the number and size of cerebral lesions. Thirty-two subjects (46%) had urinary symptoms and 38 (54%) were asymptomatic. Subjects with urinary symptoms exhibited greater overall functional disability and a higher midbrain MRI-weighted lesion score than asymptomatic patients. No statistically significant group differences were found for the other brain regions.
authors.affiliation: Department of Neurological Science, University of Rome, La Sapienza, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Pozzilli
authors.forename: M G
authors.initials: MG
authors.lastname: Grasso
authors.forename: S
authors.initials: S
authors.lastname: Bastianello
authors.forename: A
authors.initials: A
authors.lastname: Anzini
authors.forename: M
authors.initials: M
authors.lastname: Salvetti
authors.forename: L
authors.initials: L
authors.lastname: Bozzao
authors.forename: M
authors.initials: M
authors.lastname: Von Heland
authors.forename: C
authors.initials: C
authors.lastname: Fieschi
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000473:pathology*; D009460:Neurologic Examination; D001750:Urinary Bladder, Neurogenic / Q000473:pathology*