title: Synthesis and biological activities of cyclopropenone antibiotic penitricin and congeners.
abstract: A number of derivatives of the cyclopropenone antibiotic penitricin have been synthesized by the reaction of metalated cyclopropenone acetals with electrophiles. Studies on the antimicrobial structure-activity relationships indicated that the penitricin skeleton, hydroxymethylcyclopropenone, is indispensable for antimicrobial activity. These compounds were also found to display cytotoxic activity.
authors.affiliation: Department of Chemistry, Tokyo Institute of Technology, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tokuyama
authors.forename: M
authors.initials: M
authors.lastname: Isaka
authors.forename: E
authors.initials: E
authors.lastname: Nakamura
authors.forename: R
authors.initials: R
authors.lastname: Ando
authors.forename: Y
authors.initials: Y
authors.lastname: Morinaka
mesh_terms: D001419:Bacteria / Q000187:drug effects; D003521:Cyclopropanes / Q000138:chemical synthesis / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008722:Methods; D008826:Microbial Sensitivity Tests
chemical_list: D003521:Cyclopropanes; C042542:penitricin