title: Preclinical neurophysiological signs of parkinsonism in occupational manganese exposure.
abstract: To study the effects from low level exposure to manganese, 30 men at steel smelting works and 60 nonexposed reference subjects, were neurophysiologically examined using: (i) Electroencephalogram (EEG), Event related auditory evoked potential (AEP/P300), Brain stem auditory evoked potential (BAEP) and diadochokinesometry. No group differences concerning EEG or BAEP were found. Diadochokinesis was slower and there was a tendency towards prolonged P300 latency in the exposed group as compared to the referents. These effects may be interpreted as early (subclinical) signs of disturbances of the same type as parkinsonism.
authors.affiliation: Department of Neuromedicine, National Institute of Occupational Health, Solna, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Wennberg
authors.forename: M
authors.initials: M
authors.lastname: Hagman
authors.forename: L
authors.initials: L
authors.lastname: Johansson
mesh_terms: D000328:Adult; D004569:Electroencephalography / Q000187:drug effects; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects; D006801:Humans; D008297:Male; D008345:Manganese / Q000009:adverse effects*; D008669:Metallurgy; D008875:Middle Aged; D009068:Movement / Q000187:drug effects; D009784:Occupational Diseases / Q000139:chemically induced* / Q000503:physiopathology; D010302:Parkinson Disease, Secondary / Q000139:chemically induced* / Q000503:physiopathology; D012016:Reference Values
chemical_list: D008345:Manganese